WorldWideScience

Sample records for export administration regulations

  1. 75 FR 31678 - Export Administration Regulations: Technical Corrections

    Science.gov (United States)

    2010-06-04

    ... and 774 [Docket No. 0907271167-91198-01] RIN 0694-AE69 Export Administration Regulations: Technical... clarifies language concerning the de minimis provisions of the Export Administration Regulations and certain... Items The Export Administration Regulations (EAR) generally do not apply to items that were made and are...

  2. 75 FR 33682 - Export Administration Regulations; Technical Amendments

    Science.gov (United States)

    2010-06-15

    ...-01] RIN 0694-AE93 Export Administration Regulations; Technical Amendments AGENCY: Bureau of Industry... Bureau of Industry and Security (BIS) makes a technical amendment to the Export Administration... review of final decisions and orders issued in BIS export control administrative enforcement proceedings...

  3. 75 FR 33989 - Export Administration Regulations: Technical Corrections

    Science.gov (United States)

    2010-06-16

    ... 0694-AE69 Export Administration Regulations: Technical Corrections AGENCY: Bureau of Industry and... section of Export Control Classification Number 2B001 and the other is in the Technical Note on Adjusted... language regarding certain performance criteria of turning machines covered by Export Control...

  4. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Science.gov (United States)

    2010-01-01

    ... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between the Chemical Weapons Convention Regulations and the Export Administration Regulations, the International...

  5. 76 FR 77115 - Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding...

    Science.gov (United States)

    2011-12-12

    ..., and 774 [Docket No. 110627356-1475-01] RIN 0694-AF29 Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding of the Provisions That Implement the Comprehensive U.S... rule, the Bureau of Industry and Security (BIS) amends the Export Administration Regulations (EAR) by...

  6. 77 FR 22191 - Revisions to the Export Administration Regulations (EAR): Export Control Classification Number...

    Science.gov (United States)

    2012-04-13

    ..., Director, Office of National Security and Technology Transfer Controls, by phone at (202) 482-0092 or by... Administrative practice and procedure, Exports, Inventions and patents, Research science and technology. 15 CFR...

  7. 77 FR 37523 - Proposed Revisions to the Export Administration Regulations: Implementation of Export Control...

    Science.gov (United States)

    2012-06-21

    ...), respectively, that would implement various aspects of what has become known as the Export Control Reform... spirit and substance. BIS issued a notice soliciting public comment on streamlining its regulations...

  8. 78 FR 61873 - Revisions to the Export Administration Regulations (EAR) To Make the Commerce Control List (CCL...

    Science.gov (United States)

    2013-10-04

    ... entitled Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War; Submersible...'' references by this rule will require exporters to spend substantially more time to determine the scope of the...

  9. 78 FR 18814 - Amendment to the Export Administration Regulations: List of Items Classified Under Export Control...

    Science.gov (United States)

    2013-03-28

    ... Controls Division, Office of Nonproliferation and Treaty Compliance by phone at (202) 482-3343 or by email... significant military or intelligence advantage to the United States. Immediate imposition of a license... accelerate orders of these items or attempt to have the items exported prior to the imposition of the control...

  10. 77 FR 56766 - Updated Statements of Legal Authority for the Export Administration Regulations

    Science.gov (United States)

    2012-09-14

    ... necessary, to select regulatory approaches that maximize net benefits (including potential economic.... 15 CFR Part 756 Administrative practice and procedure, Exports, Penalties. 15 CFR Part 760 Boycotts...

  11. 76 FR 58393 - Updated Statements of Legal Authority for the Export Administration Regulations

    Science.gov (United States)

    2011-09-21

    ... benefits (including potential economic, environmental, public health and safety effects, distributive... Boycotts, Exports, Reporting and recordkeeping requirements. 15 CFR Part 762 Administrative practice and...

  12. 77 FR 72917 - Editorial Corrections to the Commerce Control List of the Export Administration Regulations

    Science.gov (United States)

    2012-12-07

    ...-01] RIN 0694-AF62 Editorial Corrections to the Commerce Control List of the Export Administration... corrects reference and typographical errors in the Commerce Control List (CCL) in the Export Administration... seven categories of the Commerce Control List (CCL) to correct spelling and typographical errors and...

  13. Export regulation

    International Nuclear Information System (INIS)

    Gates, D.J.

    1978-01-01

    Australia is a major uranium supplier. Uranium is exported under conditions laid down to avoid any nuclear proliferation. On 24 May 1977 the Prime Minister had stated the main elements of Australian policy: the strengthening of the system of international safeguards and the selection of importing countries. (Non-nuclear weapon states must be Contracting Parties to the NPT. Nuclear weapon states must undertake not to use Australian uranium for this purpose). Australia retains property of the uranium up to the UF 6 stage (uranium hexafluoride) in the fuel cycle; it reserves the right to stop any export if the importing country no longer complies with AIEA Safeguards. Any transfer to a third country, any irradiated fuel reprocessing, requires Australia's prior agreement. Finally, importing countries must satisfy physical protection conditions. (NEA) [fr

  14. The Export Administration Act of 1979 and Computer Exports to China

    National Research Council Canada - National Science Library

    Perez, Elizabeth

    2002-01-01

    .... The statute that regulates computer exports, the Export Administration Act of 1979 (EAA79), has been interpreted both strictly and loosely by policymakers, executive agencies, and export control regimes...

  15. 78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

    Science.gov (United States)

    2013-12-19

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 730, 732, 734, 736, 738, 740... Administration Regulations AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule. SUMMARY: This... INFORMATION CONTACT: William Arvin, Regulatory Policy Division, Bureau of Industry and Security, Telephone...

  16. 76 FR 76072 - Revisions to the Export Administration Regulations (EAR): Control of Gas Turbine Engines and...

    Science.gov (United States)

    2011-12-06

    ... intelligence advantage to the United States, and are almost exclusively available from the United States. If an...--other than ``build-to-print technology''-- for the production or development of any types of the listed... not available for the export or reexport of software and technology (other than ``build-to- print...

  17. 78 FR 40891 - Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War...

    Science.gov (United States)

    2013-07-08

    ... Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items; and Auxiliary and... Regulations: Military Vehicles; Vessels of War; Submersible Vessels, Oceanographic Equipment; Related Items... military vehicles and related items; vessels of war and related items; submersible vessels, oceanographic...

  18. Exporting licensing regulations affecting US geothermal firms

    Energy Technology Data Exchange (ETDEWEB)

    1988-08-01

    This document presents a brief introduction and overview of the Department of Commerce's Export Administration Regulations which might affect potential US geothermal goods exporters. It is intended to make US geothermal firms officials aware of the existence of such regulations and to provide them with references, contacts and phone numbers where they can obtain specific and detailed information and assistance. It must be stressed however, that the ultimate responsibility for complying with the above mentioned regulations lies with the exporter who must consult the complete version of the regulations.

  19. 76 FR 41046 - Addition of the New State of the Republic of South Sudan to the Export Administration Regulations

    Science.gov (United States)

    2011-07-13

    ... (EAR) to add controls on exports and reexports of U.S.-origin dual-use items to a new nation, the... requirements for U.S.-origin dual-use exports and reexports to the new nation. Amendments to the EAR To Add the... involves a military or foreign affairs function of the United States. (See 5 U.S.C. 553(a)(1)). This final...

  20. Nuclear export policy of the Reagan Administration

    Energy Technology Data Exchange (ETDEWEB)

    Pilat, J F; Donnelly, W H [Library of Congress, Washington, DC (USA)

    1983-06-01

    The Reagan Administration maintains the Carter Administration's objective of non-proliferation of nuclear weapons as being fundamental to US nuclear export policy. However, it sees the USA as having another important role to play in influencing the use of nuclear power and the trading of related goods and technologies in other countries. While the Administration believes its policies will prove beneficial to the USA, there is concern that trade considerations are being given priority over preventing the proliferation of nuclear weapons.

  1. 77 FR 71213 - Revisions to the Export Administration Regulations (EAR) To Make the Commerce Control List (CCL...

    Science.gov (United States)

    2012-11-29

    ... correct a grammatical error in 6C992 by removing the word ``which'' and adding in its place the word... introductory portion of Category 2, Product Group E, and the introductory Notes to Category 5, Parts I and II... exporters, reexporters and transferors, stating the following: ``See Categories V and XIV of the United...

  2. 78 FR 35195 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-06-12

    ... DEPARTMENT OF ENERGY 48 CFR Parts 925, 952, and 970 RIN 1991-AB99 Acquisition Regulations: Export... Energy (DOE) is proposing to amend the Department of Energy Acquisition Regulation (DEAR) to add export... comments, identified by ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods...

  3. 78 FR 45168 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-07-26

    ... DEPARTMENT OF ENERGY 48 CFR Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export... (78 FR 35195) to amend the Department of Energy Acquisition Regulation (DEAR) to add export control... ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods: Federal eRulemaking Portal...

  4. 75 FR 47548 - President's Export Council Subcommittee on Export Administration; Notice of Recruitment of...

    Science.gov (United States)

    2010-08-06

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security President's Export Council Subcommittee on Export Administration; Notice of Recruitment of Private-Sector Members SUMMARY: The President's Export... their services. The PECSEA is seeking private-sector members with senior export control expertise and...

  5. Final argument on regulation of electricity exports

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    Ontario Hydro addresses the request of the National Energy Board review that parties comment on the broader question of the need for federal regulation in electricity exports and the objectives which underlie the view expressed. Electricity exports benefit Canadian sellers and U.S. purchasers as well the Canadian economy in general. There is a clear consensus that these benefits exist and should be realized, but the evidence indicates that there is no consensus on how the benefits can best be distributed within Canada. The divergent views expressed by interested parties from across Canada clearly demonstrate the complexity associated with determining the overall Canadian interest and that there is a need for a balancing of these interests by a federal body. The regulation of electricity exports is clearly a matter of international commerce and Ontario Hydro submitted that the Constitution Act deems the province incompetent to regulate the export of electricity from Canada. Ontario Hydro submitted that a federal body is required in the regulation of electricity exports to protect the broader Canadian interest.

  6. Export and import. Conformity with regulations

    International Nuclear Information System (INIS)

    Shapar, M.

    1976-01-01

    Since the division of the former US Atomic Energy Commission's tasks, the regulation and control of import and export of nuclear materials and equipment has become the responsability of the Nuclear Regulatory Commission (NRC). The import and export of nuclear fuels, equipment and reactors are therefore subject to prior licensing by the Commission. This requirement aims to guarantee that such activities will not create serious hazards for defense and national safety, and that the exported products will not be diverted from their peaceful uses. The relevant applicable legal provisions are based on the Atomic Energy Act of 1954 and on the detailed regulations issued by the Commission. Under the pressure of public opinion, there is a current tendency to restrict these activities because of the hazards they present, in particular during transport, until the Commission has completed all the necessary studies. (NEA) [fr

  7. 75 FR 54857 - President's Export Council, Subcommittee on Export Administration; Notice of Recruitment of...

    Science.gov (United States)

    2010-09-09

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security President's Export Council, Subcommittee on Export Administration; Notice of Recruitment of Private-Sector Members; Date Extension Summary: The... Subcommittee will not be compensated for their services. The PECSEA is seeking private-sector members with...

  8. 76 FR 10004 - President's Export Council; Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2011-02-23

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security President's Export Council; Subcommittee on... security and foreign policy reasons. Agenda 1. Welcome by Under Secretary of Commerce for Industry and... Administration (PECSEA) will meet on March 10, 2011, 1 p.m., at the U.S. Department of Commerce, Herbert C...

  9. The nuclear export policy of the Reagan administration

    International Nuclear Information System (INIS)

    Pilat, J.F.; Donnelly, W.H.

    1983-01-01

    tThe Reagan Administration maintains the Carter Administration's objective of non-proliferation of nuclear weapons as being fundamental to US nuclear export policy. However, it sees the USA as having another important role to play in influencing the use of nuclear power and the trading of related goods and technologies in other countries. While the Administration believes its policies will prove beneficial to the USA, there is concern that trade considerations are being given priority over preventing the proliferation of nuclear weapons. (author)

  10. 77 FR 40493 - Export Administration Regulations

    Science.gov (United States)

    2012-07-10

    ... introductory text of paragraph (b)(3): Once a mass market classification request is accepted in SNAP-R, you may... supplement No. 3 to part 740 as authorized by Sec. 740.17(b) of the EAR, while the mass market classification... ``digital transfer rate'' at the highest multiplex level exceeding 45 Mb/s. * * * * * 0 4. On page 422, in...

  11. 48 CFR 652.225-71 - Section 8(a) of the Export Administration Act of 1979, as Amended.

    Science.gov (United States)

    2010-10-01

    ... to United States law or regulation. The Boycott of Israel by Arab League countries is such a boycott... Arab League Boycott of Israel, are prohibited activities under the Export Administration Act: (1..., sex, or national origin of that person or of any owner, officer, director, or employee of such person...

  12. Environmental regulation and the export dynamics of energy technologies

    International Nuclear Information System (INIS)

    Costantini, Valeria; Crespi, Francesco

    2008-01-01

    The pollution haven hypothesis affirms that an open market regime will encourage the flow of low-technology polluting industries towards developing countries because of potential comparative advantages related to low environmental standards. In contrast, the hypothesis suggested by Porter and van der Linde claims that innovating firms operate in a dynamic competitive situation which allows global diffusion of environmental-friendly technologies. Environmental regulation may represent a relevant mechanism through which technological change is induced. In this way, countries that are subject to more stringent environmental regulations may become net exporters of environmental technologies. This paper provides new evidence on the evolution of export flows of environmental technologies across different countries for the energy sector. Advanced economies, particularly the European Union, have increasingly focused on the role of energy policies as tools for sustaining the development path. The Kyoto Protocol commitments, together with growing import dependence on energy products, have brought attention to the analysis of innovation processes in this specific sector. The analysis uses a gravity model in order to test the determinants and the transmission channels through which environmental technologies for renewable energies and energy efficiency are exported to advanced and developing countries. Our results are consistent with the Porter and van der Linde hypothesis where environmental regulation represents a significant source of comparative advantages. What strongly emerges is that the stringency of environmental regulation supplemented by the strength of the National Innovation System is a crucial driver of export performance in the field of energy technologies. (author)

  13. Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

    Science.gov (United States)

    Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

    2017-02-01

    HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

  14. 76 FR 52935 - President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2011-08-24

    ... with all countries with which the United States has diplomatic or trading relations and of controlling... and Vice Chair. 2. Export Control Reform Update. 3. Presentation of Papers or Comments by the Public. 4. Review of Field Hearing. 5. Status of 2011 Workplan. 6. Discussion of 2012 Workplan. 7...

  15. 78 FR 29700 - President's Export Council; Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2013-05-21

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security President's Export Council; Subcommittee on... and Security, Space and Intelligence Systems, Building S24, Conference Center, 2020 East Imperial... security and foreign policy reasons. Agenda (Subject to Change) Tuesday, June 4 Open Session 1. Welcome and...

  16. Regulation of p53 tetramerization and nuclear export by ARC.

    Science.gov (United States)

    Foo, Roger S-Y; Nam, Young-Jae; Ostreicher, Marc Jason; Metzl, Mark D; Whelan, Russell S; Peng, Chang-Fu; Ashton, Anthony W; Fu, Weimin; Mani, Kartik; Chin, Suet-Feung; Provenzano, Elena; Ellis, Ian; Figg, Nichola; Pinder, Sarah; Bennett, Martin R; Caldas, Carlos; Kitsis, Richard N

    2007-12-26

    Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half of cancers have p53 loss-of-function mutations. Here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (ARC), a protein induced in multiple cancer cells. The direct binding in the nucleus of ARC to the p53 tetramerization domain inhibits p53 tetramerization. This exposes a nuclear export signal in p53, triggering Crm1-dependent relocation of p53 to the cytoplasm. Knockdown of endogenous ARC in breast cancer cells results in spontaneous tetramerization of endogenous p53, accumulation of p53 in the nucleus, and activation of endogenous p53 target genes. In primary human breast cancers with nuclear ARC, p53 is almost always WT. Conversely, nearly all breast cancers with mutant p53 lack nuclear ARC. We conclude that nuclear ARC is induced in cancer cells and negatively regulates p53.

  17. The nucleolus directly regulates p53 export and degradation.

    Science.gov (United States)

    Boyd, Mark T; Vlatkovic, Nikolina; Rubbi, Carlos P

    2011-09-05

    The correlation between stress-induced nucleolar disruption and abrogation of p53 degradation is evident after a wide variety of cellular stresses. This link may be caused by steps in p53 regulation occurring in nucleoli, as suggested by some biochemical evidence. Alternatively, nucleolar disruption also causes redistribution of nucleolar proteins, potentially altering their interactions with p53 and/or MDM2. This raises the fundamental question of whether the nucleolus controls p53 directly, i.e., as a site where p53 regulatory processes occur, or indirectly, i.e., by determining the cellular localization of p53/MDM2-interacting factors. In this work, transport experiments based on heterokaryons, photobleaching, and micronucleation demonstrate that p53 regulatory events are directly regulated by nucleoli and are dependent on intact nucleolar structure and function. Subcellular fractionation and nucleolar isolation revealed a distribution of ubiquitylated p53 that supports these findings. In addition, our results indicate that p53 is exported by two pathways: one stress sensitive and one stress insensitive, the latter being regulated by activities present in the nucleolus.

  18. 76 FR 16353 - International Traffic in Arms Regulations: Exemption for Temporary Export of Chemical Agent...

    Science.gov (United States)

    2011-03-23

    ... assistance. Section (c)(3) is to be revised to remove what is in practice extraneous language. Subject to the... Administrative Procedure Act The Department of State is of the opinion that controlling the import and export of... comment and without prejudice to its determination that controlling the import and export of defense...

  19. 48 CFR 1825.1103-70 - Export control.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Export control. 1825.1103...-70 Export control. (a) Background. (1) NASA contractors and subcontractors are subject to U.S. export... 120 through 130, and the Export Administration Regulations (EAR), 15 CFR parts 730 through 799. The...

  20. 78 FR 67927 - Foreign Trade Regulations (FTR): Mandatory Automated Export System Filing for All Shipments...

    Science.gov (United States)

    2013-11-13

    ... Internet at [email protected] ). FOR FURTHER INFORMATION CONTACT: Nick Orsini, Chief, Foreign Trade Division... 0607-AA50 Foreign Trade Regulations (FTR): Mandatory Automated Export System Filing for All Shipments... approval of new information collection requirements. [[Page 67928

  1. 78 FR 13463 - Editorial Corrections to the Export Administration Regulations

    Science.gov (United States)

    2013-02-28

    ... create proper subject/verb agreement. More specifically, the word ``is'' at paragraph (b)(1)(ii) is... Sec. 742.10 of the EAR to create proper subject/verb agreement. More specifically, the word ``is'' at... Juridiques et Contentieuses. Specifically, the rule misidentified ``Paris Cedex 9'' as ``Paris Codex 9...

  2. COMMODITY MARKET REGULATION: EXPORTING COUNTRIES VERSUS IMPORTING COUNTRIES

    OpenAIRE

    Souza, Leonardo Silveira

    2012-01-01

    The high in commodity prices in the international market in the last decade, tensions escalated between exporting and importing commodities countries, the extent of having their demands and pressures discussed in the main international organizations, especially in the G20. As altas nas cotações das commodities no mercado internacional na última década acirraram as tensões entre países exportadores e importadores de commodities, a ponto de terem suas reivindicações e pressões debatidas no...

  3. Permafrost conditions in peatlands regulate magnitude, timing, and chemical composition of catchment dissolved organic carbon export.

    Science.gov (United States)

    Olefeldt, David; Roulet, Nigel T

    2014-10-01

    Permafrost thaw in peatlands has the potential to alter catchment export of dissolved organic carbon (DOC) and thus influence downstream aquatic C cycling. Subarctic peatlands are often mosaics of different peatland types, where permafrost conditions regulate the hydrological setting of each type. We show that hydrological setting is key to observed differences in magnitude, timing, and chemical composition of DOC export between permafrost and nonpermafrost peatland types, and that these differences influence the export of DOC of larger catchments even when peatlands are minor catchment components. In many aspects, DOC export from a studied peatland permafrost plateau was similar to that of a forested upland catchment. Similarities included low annual export (2-3 g C m(-2) ) dominated by the snow melt period (~70%), and how substantial DOC export following storms required wet antecedent conditions. Conversely, nonpermafrost fens had higher DOC export (7 g C m(-2) ), resulting from sustained hydrological connectivity during summer. Chemical composition of catchment DOC export arose from the mixing of highly aromatic DOC from organic soils from permafrost plateau soil water and upland forest surface horizons with nonaromatic DOC from mineral soil groundwater, but was further modulated by fens. Increasing aromaticity from fen inflow to outlet was substantial and depended on both water residence time and water temperature. The role of fens as catchment biogeochemical hotspots was further emphasized by their capacity for sulfate retention. As a result of fen characteristics, a 4% fen cover in a mixed catchment was responsible for 34% higher DOC export, 50% higher DOC concentrations and ~10% higher DOC aromaticity at the catchment outlet during summer compared to a nonpeatland upland catchment. Expansion of fens due to thaw thus has potential to influence landscape C cycling by increasing fen capacity to act as biogeochemical hotspots, amplifying aquatic C cycling, and

  4. 78 FR 61743 - Revisions to the Export Administration Regulations: Initial Implementation of Export Control...

    Science.gov (United States)

    2013-10-03

    .... Munitions List (USML) on the Commerce Control List (CCL), specifically aircraft, gas turbine engines, and... Controlled section, ``Hydraulic and fuel hoses, straight and unbent lines, fittings, clips, couplings, nutplates, and brackets;'' is corrected to read ``Hydraulic and fuel hoses, straight and unbent lines...

  5. 78 FR 22659 - Revisions to the Export Administration Regulations: Initial Implementation of Export Control Reform

    Science.gov (United States)

    2013-04-16

    ..., accessories, attachments, software, and technology. This rule also adopts as much as possible a common... transition of items from the USML to the CCL, including the continued use of DDTC-issued licenses that.... Part 740--License Exceptions A. Restrictions B. License Exception TMP C. License Exception RPL D...

  6. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Science.gov (United States)

    2011-03-03

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges In the Matter of: Ali Amirnazmi, Register 63302-066, FCI... release and forfeit $81,277.37. Section 766.25 of the Export Administration Regulations (``EAR'' or...

  7. Barriers to Sustainable Food Trade: China’s Exports Food Rejected by the U.S. Food and Drug Administration 2011–2017

    Directory of Open Access Journals (Sweden)

    Xiaowei Wen

    2018-05-01

    Full Text Available Food export rejection can be a harmful barrier to sustainable international food trade. To understand China’s export food rejected by FDA (Food and Drug Administration of the United States, we analyzed 4047 cases of rejection from February 2011 to July 2017. Although the number of rejected food exported from China to the United States has been declining, and the quality has been improving, there is still space for improvement. Of the 4047 cases of rejection, the Guangdong, Fujian and Shandong provinces were the top three with the largest number of rejected food (1253 (31%, 520 (12.8%, and 508 (12.6%, respectively (being rejected mainly in New York and Los Angeles. The top four types of rejected food involved fruits and vegetables, fishery and seafood products, bakery products, grain and related processed products. More importantly, the major reasons for rejection can be attributed to problems in maintaining food safety, namely: (1 the food contained filth, decay, decomposition or other substances; (2, the food contained toxic and harmful substances (e.g., suspected melamine, chemical insecticides, or lead; and (3 the food contained agricultural and veterinary drugs. The results are of great implications for the United States to regulate the imported food from China, and for China to improve the quality and safety of export food.

  8. Nuclear localization signal regulates porcine circovirus type 2 capsid protein nuclear export through phosphorylation.

    Science.gov (United States)

    Hou, Qiang; Hou, Shaohua; Chen, Qing; Jia, Hong; Xin, Ting; Jiang, Yitong; Guo, Xiaoyu; Zhu, Hongfei

    2018-02-15

    The open reading frame 2 (ORF2) of Porcine circovirus type 2 (PCV2) encodes the major Capsid (Cap) protein, which self-assembles into virus-like particle (VLP) of similar morphology to the PCV2 virion and accumulates in the nucleus through the N-terminal arginine-rich nuclear localization signal (NLS). In this study, PCV2 Cap protein and its derivates were expressed via the baculovirus expression system, and the cellular localization of the recombinant proteins were investigated using anti-Cap mAb by imaging flow cytometry. Analysis of subcellular localization of Cap protein and its variants demonstrated that NLS mediated Cap protein nuclear export as well as nuclear import, and a phosphorylation site (S17) was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the NLS domain to regulate Cap protein nuclear export. Phosphorylation of NLS regulating the PCV2 Cap protein nuclear export was also demonstrated in PK15 cells by fluorescence microscopy. Moreover, the influence of Rep and Rep' protein on Cap protein subcellular localization was investigated in PK15 cells. Phosphorylation of NLS regulating Cap protein nuclear export provides more detailed knowledge of the PCV2 viral life cycle. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. 78 FR 29245 - U.S. General Services Administration Federal Property Management Regulations; Administrative Wage...

    Science.gov (United States)

    2013-05-20

    ... Federal Property Management Regulations; Administrative Wage Garnishment AGENCY: Office of the Chief... the U.S. General Services Administration Property Management Regulation (GSPMR) to remove information... Administrative Wage Garnishment Code of Federal Regulations (CFR) Parts affected are as follows: 41 CFR part 105...

  10. Legal principles of regulatory administration and nuclear safety regulation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyeong Hui; Cheong, Sang Kee [Hannam Univ., Taejon (Korea, Republic of)

    2000-12-15

    This research presents a critical analysis and evaluation of principles of administrative laws in order to provide framework of structural reform on the nuclear safety regulation system. The focus of this analysis and evaluation is centered around the area of origin of regulatory administrative laws; authorities of regulation; procedures of regulatory actions; regulatory enforcement; and administrative relief system. In chapter 2 the concept of regulatory administration is analysed. Chapter 3 identifies the origin of regulatory administration and the principles of administration laws. It also examines legal nature of the nuclear safety standard. In relation to regulatory authorities. Chapter 4 identifies role and responsibility of administration authorities and institutions. It also examines fundamental principles of delegation of power. Then the chapter discusses the nuclear safety regulation authorities and their roles and responsibilities. Chapter 5 classifies and examines regulatory administration actions. Chapter 6 evaluates enforcement measure for effectiveness of regulation. Finally, chapter 7 discusses the administrative relief system for reviewing unreasonable regulatory acts.

  11. The Customs Regulation of Export-Import Operations in the Context of the Deep and Comprehensive Free Trade Area between Ukraine and the EU

    Directory of Open Access Journals (Sweden)

    Kuzmin Oleh Ye.

    2017-05-01

    Full Text Available The article is concerned with the problems of reforming the customs regulation of export-import operations in the context of the Deep and Comprehensive Free Trade Area between Ukraine and the EU. Both the goods and the territorial structures of Ukraine’s export-import activities with the EU Member States were analyzed. Trends in the cooperation of the foreign economic actors in the Lviv region with the EU counterparts were explored. The key activities carried out in Ukraine in the sphere of customs regulation in the context of implementation of the Deep and Comprehensive Free Trade Area between Ukraine and the EU have been outlined and characterized, in particular: administration of tariff quotas, issuance of certificates by the customs authorities for the transport of EUR 1 goods, granting of the status of authorized exporter to economic entities, launching of an automated system of customs services «One-stop window», transition to electronic declaration, etc. The results, problematic issues and benefits of implementing the above activities in the sphere of customs regulation of the export-import activities of enterprises have been characterized.

  12. Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism.

    Science.gov (United States)

    Sugimoto, Ryusei; Watanabe, Hiroshi; Ikegami, Komei; Enoki, Yuki; Imafuku, Tadashi; Sakaguchi, Yoshiaki; Murata, Michiya; Nishida, Kento; Miyamura, Shigeyuki; Ishima, Yu; Tanaka, Motoko; Matsushita, Kazutaka; Komaba, Hirotaka; Fukagawa, Masafumi; Otagiri, Masaki; Maruyama, Toru

    2017-03-01

    Hyperuricemia occurs with increasing frequency among patients with hyperparathyroidism. However, the molecular mechanism by which the serum parathyroid hormone (PTH) affects serum urate levels remains unknown. This was studied in uremic rats with secondary hyperparathyroidism where serum urate levels were found to be increased and urate excretion in the intestine and kidney decreased, presumably due to down-regulation of the expression of the urate exporter ABCG2 in intestinal and renal epithelial membranes. These effects were prevented by administration of the calcimimetic cinacalcet, a PTH suppressor, suggesting that PTH may down-regulate ABCG2 expression. This was directly tested in intestinal Caco-2 cells where the expression of ABCG2 on the plasma membrane was down-regulated by PTH (1-34) while its mRNA level remained unchanged. Interestingly, an inactive PTH derivative (13-34) had no effect, suggesting that a posttranscriptional regulatory system acts through the PTH receptor to regulate ABCG2 plasma membrane expression. As found in an animal study, additional clinical investigations showed that treatment with cinacalcet resulted in significant reductions in serum urate levels together with decreases in PTH levels in patients with secondary hyperparathyroidism undergoing dialysis. Thus, PTH down-regulates ABCG2 expression on the plasma membrane to suppress intestinal and renal urate excretion, and the effects of PTH can be prevented by cinacalcet treatment. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  13. Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation.

    Science.gov (United States)

    Chamorro, David; Alarcón, Lourdes; Ponce, Arturo; Tapia, Rocio; González-Aguilar, Héctor; Robles-Flores, Martha; Mejía-Castillo, Teresa; Segovia, José; Bandala, Yamir; Juaristi, Eusebio; González-Mariscal, Lorenza

    2009-09-01

    Here, we have analyzed the subcellular destiny of newly synthesized tight junction protein zona occludens (ZO)-2. After transfection in sparse cells, 74% of cells exhibit ZO-2 at the nucleus, and after 18 h the value decreases to 17%. The mutation S369A located within the nuclear exportation signal 1 of ZO-2 impairs the nuclear export of the protein. Because Ser369 represents a putative protein kinase C (PKC) phosphorylation site, we tested the effect of PKC inhibition and stimulation on the nuclear export of ZO-2. Our results strongly suggest that the departure of ZO-2 from the nucleus is regulated by phosphorylation at Ser369 by novel PKCepsilon. To test the route taken by ZO-2 from synthesis to the plasma membrane, we devised a novel nuclear microinjection assay in which the nucleus served as a reservoir for anti-ZO-2 antibody. Through this assay, we demonstrate that a significant amount of newly synthesized ZO-2 goes into the nucleus and is later relocated to the plasma membrane. These results constitute novel information for understanding the mechanisms that regulate the intracellular fate of ZO-2.

  14. A peptide export-import control circuit modulating bacterial development regulates protein phosphatases of the phosphorelay.

    Science.gov (United States)

    Perego, M

    1997-08-05

    The phosphorelay signal transduction system activates developmental transcription in sporulation of Bacillus subtilis by phosphorylation of aspartyl residues of the Spo0F and Spo0A response regulators. The phosphorylation level of these response regulators is determined by the opposing activities of protein kinases and protein aspartate phosphatases that interpret positive and negative signals for development in a signal integration circuit. The RapA protein aspartate phosphatase of the phosphorelay is regulated by a peptide that directly inhibits its activity. This peptide is proteolytically processed from an inactive pre-inhibitor protein encoded in the phrA gene. The pre-inhibitor is cleaved by the protein export apparatus to a putative pro-inhibitor that is further processed to the active inhibitor peptide and internalized by the oligopeptide permease. This export-import circuit is postulated to be a mechanism for timing phosphatase activity where the processing enzymes regulate the rate of formation of the active inhibitor. The processing events may, in turn, be controlled by a regulatory hierarchy. Chromosome sequencing has revealed several other phosphatase-prepeptide gene pairs in B. subtilis, suggesting that the use of this mechanism may be widespread in signal transduction.

  15. TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages

    Directory of Open Access Journals (Sweden)

    Mary Philip

    2016-01-01

    Full Text Available Pathogenic bacteria have evolved multiple mechanisms to capture iron or iron-containing heme from host tissues or blood. In response, organisms have developed defense mechanisms to keep iron from pathogens. Very little of the body’s iron store is available as free heme; rather nearly all body iron is complexed with heme or other proteins. The feline leukemia virus, subgroup C (FeLV-C receptor, FLVCR, exports heme from cells. It was unknown whether FLVCR regulates heme-iron availability after infection, but given that other heme regulatory proteins are upregulated in macrophages in response to bacterial infection, we hypothesized that macrophages dynamically regulate FLVCR. We stimulated murine primary macrophages or macrophage cell lines with LPS and found that Flvcr is rapidly downregulated in a TLR4/MD2-dependent manner; TLR1/2 and TLR3 stimulation also decreased Flvcr expression. We identified several candidate TLR-activated transcription factors that can bind to the Flvcr promoter. Macrophages must balance the need to sequester iron from systemic circulating or intracellular pathogens with the macrophage requirement for heme and iron to produce reactive oxygen species. Our findings underscore the complexity of this regulation and point to a new role for FLVCR and heme export in macrophages responses to infection and inflammation.

  16. Regulating the Academic “Marketplace of Ideas”: Commercialization, Export Controls, and Counterintelligence

    Directory of Open Access Journals (Sweden)

    John Krige

    2015-04-01

    Full Text Available Two revolutions, not one, are transforming the research enterprise in American academia. One is the commercialization of research. The other is the regulation of research by the national security state that was accelerated by the terrorist attacks of 9/11 and focuses increasingly on the risk of sensitive knowledge leaking to China and other countries of concern. Commercialization temporarily restricts knowledge circulation to secure a patent for personal and institutional gain. Regulation controls the flow of knowledge to select foreign nationals using multiple instruments, including export controls, along with informal surveillance by the FBI. Ironically, the neoliberal urge to roll back the state and commercialize research in a competitive global knowledge economy exposes the American academic research system to the risk of “industrial” espionage and rolls out the regulatory apparatus of the national security state. Alongside offices of technology transfer on campus we now have offices of export control and compliance. Faculty and graduate students have accommodated themselves to this new situation, even while they regret it; many are concerned by the challenge that it poses to academic freedom, intellectual dynamism and political openness.

  17. The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation.

    Science.gov (United States)

    Li, Ping; Stumpf, Maria; Müller, Rolf; Eichinger, Ludwig; Glöckner, Gernot; Noegel, Angelika A

    2017-08-22

    SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1. It also binds to the NPC through association with the nuclear pore component Nup153, which is involved in mRNA export. The SUN1-NXF1 association is at least partly regulated by a protein kinase C (PKC) which phosphorylates serine 113 (S113) in the N-terminal domain leading to reduced interaction. The phosphorylation appears to be important for the SUN1 function in nuclear mRNA export since GFP-SUN1 carrying a S113A mutation was less efficient in restoring mRNA export after SUN1 knockdown as compared to the wild type protein. By contrast, GFP-SUN1-S113D resembling the phosphorylated state allowed very efficient export of poly(A)+RNA. Furthermore, probing a possible role of the LINC complex component Nesprin-2 in this process we observed impaired mRNA export in Nesprin-2 knockdown cells. This effect might be independent of SUN1 as expression of a GFP tagged SUN-domain deficient SUN1, which no longer can interact with Nesprin-2, did not affect mRNA export.

  18. Importance of dimer formation of myocardin family members in the regulation of their nuclear export.

    Science.gov (United States)

    Hayashi, Ken'ichiro; Morita, Tsuyoshi

    2013-01-01

    Myocardin (Mycd) family members function as a transcriptional cofactor for serum response factor (SRF). Dimer formation is necessary to exhibit their function, and the coiled-coil domain (CC) plays a critical role in their dimerization. We have recently revealed a detailed molecular mechanism for their Crm1 (exportin1)-mediated nuclear export. Here, we found other unique significances of the dimerization of Mycd family members. Introduction of mutations in the CC of myocardin-related transcription factor A (MRTF-A) and truncated Mycd resulted in significant decreases in their cytoplasmic localization and increases in their nuclear localization. In accordance with such subcellular localization changes, their binding to Crm1 were reduced. These results indicate that the dimerization of Mycd family members is necessary for their Crm1-mediated nuclear export. We have recently found that the N-terminal region of Mycd consisting of 128 amino acids (Mycd N128) self-associates to Mycd via the central basic domain (CB), resulting in masking the Crm1-binding site. Such self-association of MRTF-A would be unlikely. In this study, we also revealed that the dimerization of Mycd was also necessary for this self-association. Wild-type Mycd activated SRF-mediated transcription more potently than Mycd lacking the Mycd N128 (Mycd ΔN128) did. These results suggest two possible functions of the Mycd N128: 1) stabilization of Mycd dimer to enhance SRF-mediated transcription and 2) positive regulation of the transactivation ability of Mycd. These findings provide a new insight into the functional regulation of Mycd family members.

  19. LEGAL REGULATION OF ADMINISTRATIVE CONTRACTS IN BOSNIA AND HERZEGOVINA

    Directory of Open Access Journals (Sweden)

    Edina Šehrić

    2016-09-01

    Full Text Available The institute of administrative contract was mentioned for the first time in the legislation of our country in the Preliminary Draft to the Law on Amandments of the Law on Administrative Procedure of Bosnia and Herzegovina from 2012. Although insufficiently, the first step is made towards fullfillment of the reform requirements in the area of admisitrative procedure on the way to the European integration and in accordance with the changed role of administration and the need for improvement of cooperation between the administration and citizens, or legal entities. In Bosnia and Herzegovina there is still no general legal regulation of administrative contracts, but administrative contracts are subjects to specific laws and as such already exist in the legal system. After some introductory remarks, the paper deals with the concept and characteristics of administrative contracts, and also presents legal regulation of administrative contracts highlighting their specificities and differences in relation to private law contracts. The importance of general legal norm governing administrative contracts is especially emphasized, as well as their importance for reform processes in our country. Accordingly, the importance of introducing a complaint as a legal remedy that a client can use if the public authority fails to meet contractual obligations is pointed out, but also the possibility of judicial protection in case of legal dispute.

  20. 75 FR 18029 - Defense Federal Acquisition Regulation Supplement; Export-Controlled Items (DFARS Case 2004-D010)

    Science.gov (United States)

    2010-04-08

    ... regulations and prescribes a contract clause to address those responsibilities. DATES: Effective Date: April 8... activities and communication between the parties to a potential contract, and to have the resulting contract... Government needs to convey to the universities the information that certain work is export-controlled. DoD...

  1. Nuclear export policy and regulation for non-proliferation: Federal Republic of Germany

    International Nuclear Information System (INIS)

    Boulanger, Werner.

    1978-01-01

    The nuclear export policy of the Federal Republic of Germany complies with the principle of non-proliferation of nuclear weapons. Already in 1967 the Federal Government stated in a Peace Note that no export was authorised to countries (outside Euratom) which did not comply with the IAEA Safeguards. In the bilateral agreement the Federal Republic signed with Brasil in 1975, emphasis was put on international safeguards and the control exercised on exported materials to avoid any diversion for military purposes. (NEA) [fr

  2. PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network.

    Science.gov (United States)

    Shiwarski, Daniel J; Darr, Marlena; Telmer, Cheryl A; Bruchez, Marcel P; Puthenveedu, Manojkumar A

    2017-08-01

    The interplay between signaling and trafficking by G protein-coupled receptors (GPCRs) has focused mainly on endocytic trafficking. Whether and how surface delivery of newly synthesized GPCRs is regulated by extracellular signals is less understood. Here we define a signaling-regulated checkpoint at the trans -Golgi network (TGN) that controls the surface delivery of the delta opioid receptor (δR). In PC12 cells, inhibition of phosphoinositide-3 kinase (PI3K) activity blocked export of newly synthesized δR from the Golgi and delivery to the cell surface, similar to treatment with nerve growth factor (NGF). Depletion of class II phosphoinositide-3 kinase α (PI3K C2A), but not inhibition of class I PI3K, blocked δR export to comparable levels and attenuated δR-mediated cAMP inhibition. NGF treatment displaced PI3K C2A from the Golgi and optogenetic recruitment of the PI3K C2A kinase domain to the TGN-induced δR export downstream of NGF. Of importance, PI3K C2A expression promotes export of endogenous δR in primary trigeminal ganglion neurons. Taken together, our results identify PI3K C2A as being required and sufficient for δR export and surface delivery in neuronal cells and suggest that it could be a key modulator of a novel Golgi export checkpoint that coordinates GPCR delivery to the surface. © 2017 Shiwarski et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  3. Export controls on high technology

    Energy Technology Data Exchange (ETDEWEB)

    Frank, N.K.

    1987-01-01

    A overview of the Export Administration Act of 1979 and subsequent regulations and amendments focuses on how licensing requirements and restrictions against boycott affect high technology exports. The purpose of these controls is to limit the export of technology with possible military applications, as well as to advance US foreign policy and protect the economy without imposing too great a restriction on the principles of free trade. Thus, the act encompasses political, economic, and security goals. Problems of predictability arise when embargoes or other controls are imposed for political or foreign policy reasons without regard to economic impacts. Amendments have attempted to streamline the exporting process, particularly in the area of computer and software licensing.

  4. 78 FR 61749 - Amendment to the International Traffic in Arms Regulations: Initial Implementation of Export...

    Science.gov (United States)

    2013-10-03

    ... for marketing purposes and not previously licensed for export in accordance with this subchapter. I.... I-XXI Defense articles and X X services specific to sensor fusion beyond that required for display...

  5. MEB 2013, Regulation for Administrator Assignment and Relocation Based On the Opinions of Administrators

    Directory of Open Access Journals (Sweden)

    Soner DOĞAN

    2014-04-01

    Full Text Available In this study; it is aimed to determine the opinions of the institution managers concerning the Regulation for Administrator Assignment and Relocation dated February 28, 2013, the scoring criteria in the regulation and the disturbances experienced in the application process of the regulation. The study is carried out in accordance with the phenomenological pattern through qualitative research methods. The participants were determined with the criterion sampling method which is one of the purposeful sampling methods. The study group of the research is composed of the eight managers serving in a province. In the study, a semi-structured interview form was used as data collection tool. In the interpretation process of the interviews, the inductive descriptive analysis, the content analysis and the constant comparison technique were used. Three main themes have come out regarding the result of the data analysis process of assigning the administrators, the combining of the different types of institutions and the application of the forced relocation.

  6. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.

    Science.gov (United States)

    Corum, Daniel G; Tsichlis, Philip N; Muise-Helmericks, Robin C

    2014-01-01

    Our previous work has shown that Akt3 is required for mitochondrial biogenesis in primary human endothelial cells (ECs) and in Akt3-null mice; Akt3 affects subcellular localization of peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α), the master regulator of mitochondrial biogenesis. The purpose of this study is to determine the mechanism by which Akt3 controls the subcellular distribution of PGC-1α and to explore the effect on mitochondrial biogenesis and turnover during angiogenesis. Here we use standard biochemical analyses and Akt3-knockdown strategies to show that Akt3 controls the stabilization of chromosome maintenance region-1 (CRM-1), the major nuclear export receptor. Site-directed mutagenesis and association analyses show that PGC-1α nuclear export is CRM-1 dependent. Akt3 knockdown and CRM-1 overexpression cause 3-fold reductions in PGC-1α target gene expression, compared to control levels. Akt3 inhibition causes autophagy, as measured by autophagosome formation, in a CRM-1-dependent, Akt1/mTOR-independent pathway. In vivo, Akt3-null and heterozygous mice show dose-dependent decreases in angiogenesis compared to wild-type littermates (~5- and 2.5-fold decreases, respectively), as assessed by Matrigel plug assays. This correlates with an ~1.5-fold decrease in mitochondrial Cox IV expression. Our studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation of CRM-1-dependent nuclear export.

  7. 78 FR 16365 - Foreign Trade Regulations: Mandatory Automated Export System Filing for All Shipments Requiring...

    Science.gov (United States)

    2013-03-14

    ... Bureau revised this definition to clarify that the FPPI is the party that purchases the goods. Foreign... the EAR that provides requirements for a license exception for gift parcels and humanitarian donations... interest (FPPI)'' to clarify that the FPPI is the party that purchases the goods for export or to whom...

  8. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Science.gov (United States)

    2010-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware River...

  9. The future of Russian gas exports

    International Nuclear Information System (INIS)

    Rodiononv, Alexander; Krasheninnikov, Yuri; Panin, Sergei

    1999-12-01

    Contains Executive Summary and Chapters on: Introduction; The structure of Russian gas exports; Exports to Europe; Exports to Turkey/Middle East; Exports to Asia/Pacific Rim; FSU gas exports; Regulations for exporting gas from Russia; Equipment and services. (Author)

  10. Regulations of 10 January 1989 relating to the implementation of control of the export of strategic goods, services and technology, laid down by the ministry of foreign affairs

    International Nuclear Information System (INIS)

    1989-01-01

    These Regulations were made by the Ministry of Foreign Affairs in pursuance of Act No. 93 of 18 December 1987 on the control of the export of strategic goods, services and technology, in particular nuclear material, equipment, technology and services. The Regulations entered into force on 15 February 1989. That Ministry compiles lists of goods requiring an export licence or permission which also cover nuclear installations, material and equipment. The Regulations provide that the Ministry may require that an application for export of such goods, etc. be accompanied by a statement on the final use of the goods concerned (end-use statement) ascertaining that they will not be re-exported without the consent of the Norwegian authorities [fr

  11. Nuclear exports. Parliamentary control and confidentiality

    International Nuclear Information System (INIS)

    Feldmann, Ulrike

    2015-01-01

    With its decision taken on 21. October 2014 (Az.: 2 BvE 5/11) the Federal Constitutional Court (BVerfG) decided during court proceedings between administrative bodies on the scope and limits of the parliamentary right of information. Even though the proceeding did not deal with nuclear exports but arm exports, foreign trade law, however, does not only designate an export licence obligation for military weapons but also for so called dual-use goods meaning goods, which can be used both for friendly as well as for military purposes. The export of these goods requires according to the so-called Dual-Use Regulation (EG) 428/2009 a licence. Annex I category 0 of the regulation (EG) 428/2009 lists a variety of nuclear materials, plants and equipment items for which this licence applies. In the same manner as arm exports, also exports of nuclear dual-use goods are being discussed in a special cabinet committee, the Federal Security Council (BSR), which shall coordinate cross-departmentally the German security and defence policy under consideration of economic interests and which categorises its results, according to the rules of procedure, as confidential. Also legally not regulated but common ''preliminary enquiries'' at the responsible Federal Ministry or rather Federal Office of Economics and Export Control by companies which plan an export and want to affirm the general approval for their export business prior to conclusion of contract take not only place for arm exports but also for nuclear dual-use goods. The decision by the Federal Constitutional Court can be applied to consultations about the authorisation of nuclear dual-use goods.

  12. 77 FR 70945 - Revisions to the Export Administration Regulations (EAR): Control of Military Electronic...

    Science.gov (United States)

    2012-11-28

    ... but was nonetheless a type of article that is, as a result of differences in form and fit, ``specially... (telecommunications), and 6 (radar). BIS, however, proposes including cross references in CCL Categories 4, 5, and 6..., 5A980, and 5A991. New Cross Reference ECCNs Three new cross reference ECCNs would be created to alert...

  13. 76 FR 76085 - Revisions to the Export Administration Regulations (EAR): Control of Military Vehicles and...

    Science.gov (United States)

    2011-12-06

    ... systems to limit vehicle wiring; tire pressure monitoring systems; and data relating to tires (not including run-flats). Although these items might have to be modified for a particular military vehicle, such...

  14. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Science.gov (United States)

    2010-07-01

    ... not directly and significantly related to design, production, or utilization in industrial processes... under contract related directly and significantly to design, production, or utilization in industrial...

  15. 78 FR 55664 - Revisions to the Export Administration Regulations (EAR): Unverified List (UVL)

    Science.gov (United States)

    2013-09-11

    ... criteria for adding foreign persons to the Entity List and the Unverified List based on a lack of... subject to the EAR), where an end- use check, such as a pre-license check (PLC) or a post-shipment... persons because an end-use check, such as a PLC or a PSV, cannot be completed satisfactorily for reasons...

  16. 78 FR 76741 - Revisions to the Export Administration Regulations (EAR): Unverified List (UVL)

    Science.gov (United States)

    2013-12-19

    ... adding foreign persons to the Entity List and the Unverified List based on a lack of cooperation with an... to the EAR), where an end- use check, such as a pre-license check (PLC) or a post-shipment... PLC or a PSV, cannot be completed satisfactorily for reasons outside of the U.S. Government's control...

  17. 77 FR 35310 - Revisions to the Export Administration Regulations (EAR): Control of Military Training Equipment...

    Science.gov (United States)

    2012-06-13

    ... for foreign made ``military commodities'' that incorporate more than 10% U.S.-origin ``600 series... Military Training Equipment and Related Items the President Determines No Longer Warrant Control Under the... longer warrant control under Category IX (Military Training Equipment and Training) of the United States...

  18. 77 FR 33688 - Revisions to the Export Administration Regulations (EAR): Control of Personal Protective...

    Science.gov (United States)

    2012-06-07

    ... United States arms embargo or a United Nations Security Council arms embargo. A list of such destinations... of the helmets to Rwanda and Iraq since Rwanda is no longer subject to a UN arms embargo and since... current UN arms embargo on Iraq. This change would also impose a new CCL-based license requirement for...

  19. 78 FR 42430 - Revisions to the Export Administration Regulations Based on the 2012 Missile Technology Control...

    Science.gov (United States)

    2013-07-16

    ... that are generally: a. Characterized by high nickel, very low carbon content and use substitutional... the ``development'' of fly-by-wire control systems), 0E521 No. 6 (for ``technology'' for the...

  20. 78 FR 45026 - Revisions to the Export Administration Regulations (EAR): Control of Military Electronic...

    Science.gov (United States)

    2013-07-25

    ... ECCN 3A611.c and .d should cover microwave monolithic integrated circuits and discrete microwave... and are not controlled. One commenter noted that placing monolithic microware integrated circuit power...: One commenter recommended removing the technical parameters for microwave monolithic integrated...

  1. 76 FR 80291 - Revisions to the Export Administration Regulations (EAR): Control of Submersible Vessels...

    Science.gov (United States)

    2011-12-23

    ... rule and to avoid, to the extent possible, situations where transactions would require licenses from... align the CCL with the WAML and the Missile Technology Control Regime Equipment, Software and Technology..., which currently impose a license requirement for five countries. A license also would be required, in...

  2. 78 FR 31431 - Export Administration Regulations (EAR): Control of Spacecraft Systems and Related Items the...

    Science.gov (United States)

    2013-05-24

    ... inappropriate to include these types of items in the ``600 series,'' which is, by definition, comprised of... also add a new definition for the ``500 series'' to Sec. 772.1. The new ``500 series'' would not... space tourism, research or scientific endeavors, or transportation from one point to another for...

  3. 78 FR 43972 - Amendments to the Export Administration Regulations: Implementation of Limited Syria Waiver for...

    Science.gov (United States)

    2013-07-23

    ... Syria Accountability and Lebanese Sovereignty Restoration Act of 2003 (the SAA). The waiver authorizes..., agricultural production and food processing, power generation, oil and gas production, construction and.... SUPPLEMENTARY INFORMATION: Background In the Syria Accountability and Lebanese Sovereignty Restoration Act of...

  4. 75 FR 20520 - Revisions to the Export Administration Regulations Based on the 2009 Missile Technology Control...

    Science.gov (United States)

    2010-04-20

    ... were agreed to by MTCR member countries at the November 2009 Plenary in Rio de Janeiro, Brazil. In... Rio de Janeiro, Brazil. Corresponding MTCR Annex references are provided below for the MTCR Annex...

  5. 76 FR 41957 - Proposed Revisions to the Export Administration Regulations (EAR): Control of Items the President...

    Science.gov (United States)

    2011-07-15

    ... Conference 2010. Commerce Secretary Locke and other senior members of BIS also spoke at the same BIS Update Conference, along with other senior members of the Departments of State and Defense, regarding the importance..., Belarus, Burma, China, Cuba, Cote d'Ivoire, Cyprus, Democratic Republic of Congo, Eritrea, Haiti, Iraq...

  6. 77 FR 29564 - Revisions to the Export Administration Regulations: Auxiliary and Miscellaneous Items That No...

    Science.gov (United States)

    2012-05-18

    ... provide a critical military or intelligence advantage to the United States, and that are almost... compared to items currently controlled under ECCN 0A918. For this reason, there is no longer a need to... match their business relationship rather than applying repeatedly for licenses with every purchase order...

  7. 77 FR 25932 - Revisions to the Export Administration Regulations (EAR): Control of Energetic Materials and...

    Science.gov (United States)

    2012-05-02

    ... 1B608 that is ``specially designed'' for the ``production'' of rocket propellants; oxidizers or mixtures... would control equipment for the ``production'' of explosives and solid propellants, currently controlled...), this rule would move ``equipment'' for the ``production'' of explosives and solid propellants...

  8. 78 FR 6750 - Revisions to the Export Administration Regulations (EAR): Articles the President Determines No...

    Science.gov (United States)

    2013-01-31

    ... mail or delivery to Regulatory Policy Division, Bureau of Industry and Security, U.S. Department of..., Iraq, Iran, Lebanon, Liberia, Libya, North Korea, Somalia, Sri Lanka, Sudan, Syria, Venezuela, Vietnam... under ECCN 0E604 or 9E604 would be subject to the licensing policies that apply to items controlled for...

  9. 76 FR 68675 - Revisions to the Export Administration Regulations (EAR): Control of Aircraft and Related Items...

    Science.gov (United States)

    2011-11-07

    ... parameters or characteristics that provide a critical military or intelligence advantage to the United States... personnel, ECCN 9D610 software and ECCN 9E610 technology (other than ``build-to-print technology'') for the... (other than ``build-to-print technology'') for the production of 15 types of ECCN 9A610.x parts and...

  10. 15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Science.gov (United States)

    2010-01-01

    ... of the Nonproliferation Center of the Central Intelligence Agency are non-voting members. The...; household utilities and appliances; printing, reproduction, imaging and video recording or playback (but not... (including command, control and intelligence applications) which are controlled by the Department of State on...

  11. SRSF3 represses the expression of PDCD4 protein by coordinated regulation of alternative splicing, export and translation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seung Kuk; Jeong, Sunjoo, E-mail: sjsj@dankook.ac.kr

    2016-02-05

    Gene expression is regulated at multiple steps, such as transcription, splicing, export, degradation and translation. Considering diverse roles of SR proteins, we determined whether the tumor-related splicing factor SRSF3 regulates the expression of the tumor-suppressor protein, PDCD4, at multiple steps. As we have reported previously, knockdown of SRSF3 increased the PDCD4 protein level in SW480 colon cancer cells. More interestingly, here we showed that the alternative splicing and the nuclear export of minor isoforms of pdcd4 mRNA were repressed by SRSF3, but the translation step was unaffected. In contrast, only the translation step of the major isoform of pdcd4 mRNA was repressed by SRSF3. Therefore, overexpression of SRSF3 might be relevant to the repression of all isoforms of PDCD4 protein levels in most types of cancer cell. We propose that SRSF3 could act as a coordinator of the expression of PDCD4 protein via two mechanisms on two alternatively spliced mRNA isoforms.

  12. An analysis on the export license criteria for NSG control items in the US and Japan

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Young Rok [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-06-01

    Korea has taken steps to join the Nuclear Suppliers Group (NSG) which is a major part of the international nuclear export control regime. In this connection, it is an urgent task to build a new Korean nuclear export control system that includes NSG guidelines and control items. In addition, it is necessary to review the developed supplier countries` experience in the field of export control. The main purpose of this study is to analyze how the US and Japan have controlled the items listed in NSG part 1 and 2 guidelines. To this end, various relevant regulations of the US and Japan were studied. Among those regulations, the US Export Administration Regulation, US 10 CFR 110 and 810, and the Japan`s Export Administration Order are included. Through the review process, this study identified NSG items which are controlled in the export control systems of the US and Japan. Furthermore, this study summarized and compared the export license criteria that must be satisfied before exporting each NSG item in the two countries. The export license criteria consist of permitted destinations, document requirements, and types of license. The results of this study are expected to contribute to establishing an appropriate Korean nuclear export control system and could be used as references to the practical export licensing policies of the US and Japan. 6 tabs., 13 refs., (Author) .new.

  13. An analysis on the export license criteria for NSG control items in the US and Japan

    International Nuclear Information System (INIS)

    Choi, Young Rok

    1995-06-01

    Korea has taken steps to join the Nuclear Suppliers Group (NSG) which is a major part of the international nuclear export control regime. In this connection, it is an urgent task to build a new Korean nuclear export control system that includes NSG guidelines and control items. In addition, it is necessary to review the developed supplier countries' experience in the field of export control. The main purpose of this study is to analyze how the US and Japan have controlled the items listed in NSG part 1 and 2 guidelines. To this end, various relevant regulations of the US and Japan were studied. Among those regulations, the US Export Administration Regulation, US 10 CFR 110 and 810, and the Japan's Export Administration Order are included. Through the review process, this study identified NSG items which are controlled in the export control systems of the US and Japan. Furthermore, this study summarized and compared the export license criteria that must be satisfied before exporting each NSG item in the two countries. The export license criteria consist of permitted destinations, document requirements, and types of license. The results of this study are expected to contribute to establishing an appropriate Korean nuclear export control system and could be used as references to the practical export licensing policies of the US and Japan. 6 tabs., 13 refs., (Author) .new

  14. A novel mechanism of E2F1 regulation via nucleocytoplasmic shuttling: determinants of nuclear import and export.

    Science.gov (United States)

    Ivanova, Iordanka A; Vespa, Alisa; Dagnino, Lina

    2007-09-01

    E2F1 is a transcription factor central for cell survival, proliferation, and repair following genomic insult. Depending on the cell type and conditions, E2F1 can induce apoptosis in transformed cells, behaving as a tumour suppressor, or impart growth advantages favouring tumour formation. The pleiotropic functions of E2F1 are a likely consequence of its ability to transcriptionally control a wide variety of target genes, and require tight regulation of its activity at multiple levels. Although sequestration of proteins to particular cellular compartments is a well-established regulatory mechanism, virtually nothing is known about its contribution to modulation of E2F1 target gene expression. We have examined the subcellular trafficking of E2F1 and, contrary to the widely held notion that this factor is constitutively nuclear, we now demonstrate that it is subjected to continuous nucleocytoplasmic shuttling. We have also defined two nuclear localization domains and a nuclear export region, which mediates CRM1-dependent transit out of the nucleus. The predominant subcellular location of E2F1 is likely determined by the balance between the activity of nuclear import and export domains, and can be modulated by differentiation stimuli in epidermal cells. Thus, we have identified a hitherto unrecognized mechanism to control E2F1 function through modulation of its subcellular localization.

  15. The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.

    Directory of Open Access Journals (Sweden)

    Keith Cha

    Full Text Available The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment. In mammalian cells, unmodified RanGAP1 is predominantly cytoplasmic, whereas modification by small ubiquitin-related modifier protein (SUMO targets RanGAP1 to the cytoplasmic filaments of nuclear pore complex (NPC. Although RanGAP1 contains nine putative nuclear export signals and a nuclear localization signal, little is known if RanGAP1 shuttles between the nuclear and cytoplasmic compartments and how its primary localization in the cytoplasm and at the NPC is regulated. Here we show that inhibition of CRM1-mediated nuclear export using RNAi-knockdown of CRM1 and inactivation of CRM1 by leptomycin B (LMB results in nuclear accumulation of RanGAP1. LMB treatment induced a more robust redistribution of RanGAP1 from the cytoplasm to the nucleoplasm compared to CRM1 RNAi and also uniquely triggered a decrease or loss of RanGAP1 localization at the NPC, suggesting that LMB treatment is more effective in inhibiting CRM1-mediated nuclear export of RanGAP1. Our time-course analysis of LMB treatment reveals that the NPC-associated RanGAP1 is much more slowly redistributed to the nucleoplasm than the cytoplasmic RanGAP1. Furthermore, LMB-induced nuclear accumulation of RanGAP1 is positively correlated with an increase in levels of SUMO-modified RanGAP1, suggesting that SUMOylation of RanGAP1 may mainly take place in the nucleoplasm. Lastly, we demonstrate that the nuclear localization signal at the C-terminus of RanGAP1 is required for its nuclear accumulation in cells treated with LMB. Taken together, our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC localization of RanGAP1 is dependent on CRM1-mediated nuclear export.

  16. Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

    Science.gov (United States)

    Vinchi, Francesca; Ingoglia, Giada; Chiabrando, Deborah; Mercurio, Sonia; Turco, Emilia; Silengo, Lorenzo; Altruda, Fiorella; Tolosano, Emanuela

    2014-05-01

    The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural products, hormones, drugs, and carcinogens. Feline leukemia virus subgroup C cellular receptor 1a (FLVCR1a) is plasma membrane heme exporter that is ubiquitously expressed and controls intracellular heme content in hematopoietic lineages. We investigated the role of Flvcr1a in liver function in mice. We created mice with conditional disruption of Mfsd7b, which encodes Flvcr1a, in hepatocytes (Flvcr1a(fl/fl);alb-cre mice). Mice were analyzed under basal conditions, after phenylhydrazine-induced hemolysis, and after induction of cytochromes P450 synthesis. Livers were collected and analyzed by histologic, quantitative real-time polymerase chain reaction, and immunoblot analyses. Hepatic P450 enzymatic activities were measured. Flvcr1a(fl/fl);alb-cre mice accumulated heme and iron in liver despite up-regulation of heme oxygenase 1, ferroportin, and ferritins. Hepatic heme export activity of Flvcr1a was closely associated with heme biosynthesis, which is required to sustain cytochrome induction. Upon cytochromes P450 stimulation, Flvcr1a(fl/fl);alb-cre mice had reduced cytochrome activity, associated with accumulation of heme in hepatocytes. The expansion of the cytosolic heme pool in these mice was likely responsible for the early inhibition of heme synthesis and increased degradation of heme, which reduced expression and activity of cytochromes P450. In livers of mice, Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity. These findings have important implications for drug metabolism. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

  17. Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450

    Science.gov (United States)

    Vinchi, Francesca; Ingoglia, Giada; Chiabrando, Deborah; Mercurio, Sonia; Turco, Emilia; Silengo, Lorenzo; Altruda, Fiorella; Tolosano, Emanuela

    2014-01-01

    Background & Aims The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural products, hormones, drugs, and carcinogens. Feline leukemia virus subgroup C cellular receptor 1a (FLVCR1a) is plasma membrane heme exporter that is ubiquitously expressed and controls intracellular heme content in hematopoietic lineages. We investigated the role of Flvcr1a in liver function in mice. Methods We created mice with conditional disruption of Mfsd7b, which encodes Flvcr1a, in hepatocytes (Flvcr1afl/fl;alb-cre mice). Mice were analyzed under basal conditions, after phenylhydrazine-induced hemolysis, and after induction of cytochromes P450 synthesis. Livers were collected and analyzed by histologic, quantitative real-time polymerase chain reaction, and immunoblot analyses. Hepatic P450 enzymatic activities were measured. Results Flvcr1afl/fl;alb-cre mice accumulated heme and iron in liver despite up-regulation of heme oxygenase 1, ferroportin, and ferritins. Hepatic heme export activity of Flvcr1a was closely associated with heme biosynthesis, which is required to sustain cytochrome induction. Upon cytochromes P450 stimulation, Flvcr1afl/fl;alb-cre mice had reduced cytochrome activity, associated with accumulation of heme in hepatocytes. The expansion of the cytosolic heme pool in these mice was likely responsible for the early inhibition of heme synthesis and increased degradation of heme, which reduced expression and activity of cytochromes P450. Conclusions In livers of mice, Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 expression and activity. These findings have important implications for drug metabolism. PMID:24486949

  18. 7 CFR 800.17 - Special inspection and weighing requirements for sacked export grain.

    Science.gov (United States)

    2010-01-01

    ... sacked export grain. 800.17 Section 800.17 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE... Requirements § 800.17 Special inspection and weighing requirements for sacked export grain. (a) General...

  19. 41 CFR 105-1.101 - General Services Administration Property Management Regulations.

    Science.gov (United States)

    2010-07-01

    ...-INTRODUCTION 1.1-Regulations System § 105-1.101 General Services Administration Property Management Regulations... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General Services Administration Property Management Regulations. 105-1.101 Section 105-1.101 Public Contracts and Property...

  20. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2012-02-24

    ...D published an initial proposed rule for Business Systems-- Definition and Administration (DFARS... the definition and administration of contractor business systems as follows: A. Contractor business..., 245, and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems...

  1. 77 FR 66844 - Federal Acquisition Regulation; Submission for OMB Review; Evaluation of Export Offers

    Science.gov (United States)

    2012-11-07

    ... Management and Budget (OMB) a request to review and approve an extension of a previously approved information... posted without change to http://www.regulations.gov , including any personal and/or business confidential... United States (CONUS) ports and offers are solicited on a free onboard (f.o.b.) origin or f.o.b...

  2. 76 FR 18995 - Pesticides; Regulation to Clarify Labeling of Pesticides for Export

    Science.gov (United States)

    2011-04-06

    ...) 308-9069; fax number: (703) 305-5884; e- mail address: au.vera@epa.gov . SUPPLEMENTARY INFORMATION: I... identification (ID) number EPA-HQ--OPP-2009-0607, by one of the following methods: Federal eRulemaking Portal....gov or e-mail. The regulations.gov Web site is an ``anonymous access'' system, which means EPA will...

  3. 77 FR 25865 - Amendment to the International Traffic in Arms Regulations: Exemption for Temporary Export of...

    Science.gov (United States)

    2012-05-02

    ... difficulties in certain instances (for example, departing on a U.S. military airplane from a U.S. military base). According to law and regulations, persons who claim this exemption must submit the articles for CBP...) for the individual to declare to CBP his intention of returning the articles upon each return to the...

  4. Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export

    Directory of Open Access Journals (Sweden)

    Marriott Susan J

    2007-12-01

    Full Text Available Abstract Background The HTLV-I oncoprotein, Tax, is a pleiotropic protein whose activity is partially regulated by its ability to interact with, and perturb the functions of, numerous cellular proteins. Tax is predominantly a nuclear protein that localizes to nuclear foci known as Tax Speckled Structures (TSS. We recently reported that the localization of Tax and its interactions with cellular proteins are altered in response to various forms of genotoxic and cellular stress. The level of cytoplasmic Tax increases in response to stress and this relocalization depends upon the interaction of Tax with CRM1. Cellular pathways and signals that regulate the subcellular localization of Tax remain to be determined. However, post-translational modifications including sumoylation and ubiquitination are known to influence the subcellular localization of Tax and its interactions with cellular proteins. The sumoylated form of Tax exists predominantly in the nucleus while ubiquitinated Tax exists predominantly in the cytoplasm. Therefore, we hypothesized that post-translational modifications of Tax that occur in response to DNA damage regulate the localization of Tax and its interactions with cellular proteins. Results We found a significant increase in mono-ubiquitination of Tax in response to UV irradiation. Mutation of specific lysine residues (K280 and K284 within Tax inhibited DNA damage-induced ubiquitination. In contrast to wild-type Tax, which undergoes transient nucleocytoplasmic shuttling in response to DNA damage, the K280 and K284 mutants were retained in nuclear foci following UV irradiation and remained co-localized with the cellular TSS protein, sc35. Conclusion This study demonstrates that the localization of Tax, and its interactions with cellular proteins, are dynamic following DNA damage and depend on the post-translational modification status of Tax. Specifically, DNA damage induces the ubiquitination of Tax at K280 and K284

  5. RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast

    Energy Technology Data Exchange (ETDEWEB)

    Iida, Tetsushi, E-mail: tiida@nig.ac.jp [Division of Cytogenetics, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012 (Japan); Iida, Naoko [Division of Mutagenesis, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Tsutsui, Yasuhiro [Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama 226-8501 (Japan); Yamao, Fumiaki [Division of Mutagenesis, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Kobayashi, Takehiko [Division of Cytogenetics, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan)

    2012-10-12

    Highlights: Black-Right-Pointing-Pointer RNAi is linked to the cell cycle checkpoint in fission yeast. Black-Right-Pointing-Pointer Ptr1 co-purifies with Ago1. Black-Right-Pointing-Pointer The ptr1-1 mutation impairs the checkpoint but does not affect gene silencing. Black-Right-Pointing-Pointer ago1{sup +} and ptr1{sup +} regulate the cell cycle checkpoint via the same pathway. Black-Right-Pointing-Pointer Mutations in ago1{sup +} and ptr1{sup +} lead to the nuclear accumulation of poly(A){sup +} RNAs. -- Abstract: Ago1, an effector protein of RNA interference (RNAi), regulates heterochromatin silencing and cell cycle arrest in fission yeast. However, the mechanism by which Ago1 controls cell cycle checkpoint following hydroxyurea (HU) treatment has not been elucidated. In this study, we show that Ago1 and other RNAi factors control cell cycle checkpoint following HU treatment via a mechanism independent of silencing. While silencing requires dcr1{sup +}, the overexpression of ago1{sup +} alleviated the cell cycle defect in dcr1{Delta}. Ago1 interacted with the mRNA export factor, Ptr1. The ptr1-1 mutation impaired cell cycle checkpoint but gene silencing was unaffected. Genetic analysis revealed that the regulation of cell cycle checkpoint by ago1{sup +} is dependent on ptr1{sup +}. Nuclear accumulation of poly(A){sup +} RNAs was detected in mutants of ago1{sup +} and ptr1{sup +}, suggesting there is a functional link between the cell cycle checkpoint and RNAi-mediated RNA quality control.

  6. Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1*

    Science.gov (United States)

    Hsieh, Victar; Kim, Mi-Jurng; Gelissen, Ingrid C.; Brown, Andrew J.; Sandoval, Cecilia; Hallab, Jeannette C.; Kockx, Maaike; Traini, Mathew; Jessup, Wendy; Kritharides, Leonard

    2014-01-01

    The objective of this study was to examine the influence of cholesterol in post-translational control of ABCA1 and ABCG1 protein expression. Using CHO cell lines stably expressing human ABCA1 or ABCG1, we observed that the abundance of these proteins is increased by cell cholesterol loading. The response to increased cholesterol is rapid, is independent of transcription, and appears to be specific for these membrane proteins. The effect is mediated through cholesterol-dependent inhibition of transporter protein degradation. Cell cholesterol loading similarly regulates degradation of endogenously expressed ABCA1 and ABCG1 in human THP-1 macrophages. Turnover of ABCA1 and ABCG1 is strongly inhibited by proteasomal inhibitors and is unresponsive to inhibitors of lysosomal proteolysis. Furthermore, cell cholesterol loading inhibits ubiquitination of ABCA1 and ABCG1. Our findings provide evidence for a rapid, cholesterol-dependent, post-translational control of ABCA1 and ABCG1 protein levels, mediated through a specific and sterol-sensitive mechanism for suppression of transporter protein ubiquitination, which in turn decreases proteasomal degradation. This provides a mechanism for acute fine-tuning of cholesterol transporter activity in response to fluctuations in cell cholesterol levels, in addition to the longer term cholesterol-dependent transcriptional regulation of these genes. PMID:24500716

  7. 29 CFR 790.17 - “Administrative regulation, order, ruling, approval, or interpretation.”

    Science.gov (United States)

    2010-07-01

    ... 1938 Defense of Good Faith Reliance on Administrative Regulations, Etc. § 790.17 “Administrative... in regard to their function under the “good faith” defense. Accordingly, no useful purpose would be... that where the employer's good faith reliance on a regulation, order, ruling, approval or...

  8. 77 FR 9659 - General Services Administration Acquisition Regulation; Information Collection; GSA Mentor...

    Science.gov (United States)

    2012-02-17

    ... Services Administration Acquisition Regulation; Information Collection; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration...- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations.gov : http...

  9. 77 FR 31016 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor...

    Science.gov (United States)

    2012-05-24

    ... Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration... Collection 3090- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations...

  10. 75 FR 77561 - Regulations Issued Under the Export Grape and Plum Act; Revision to the Minimum Requirements

    Science.gov (United States)

    2010-12-13

    ... amount of product sold and an increase in returns to producers, shippers, exporters, and carriers... additional 2 percent tolerance for sealed berry cracks on the Exotic grape variety. This action was... minimum size and quality requirements for export shipments of any variety of vinifera species table grapes...

  11. 76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

    Science.gov (United States)

    2011-05-18

    ...; Business Systems-- Definition and Administration; Interim Rule #0;#0;Federal Register / Vol. 76 , No. 96...-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration... an initial proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038...

  12. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ...; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD... collection requirement concerning cost accounting standards administration. A notice was published in the...- 0129, Cost Accounting Standards Administration by any of the following methods: Regulations.gov : http...

  13. Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase

    International Nuclear Information System (INIS)

    Fujita, Akiko; Sato, Chihiro; Kitajima, Ken.

    2007-01-01

    The CMP-sialic acid synthetase (CSS) catalyzes the activation of sialic acid (Sia) to CMP-Sia which is a donor substrate of sialyltransferases. The vertebrate CSSs are usually localized in nucleus due to the nuclear localization signal (NLS) on the molecule. In this study, we first point out that a small, but significant population of the mouse CMP-sialic acid synthetase (mCSS) is also present in cytoplasm, though mostly in nucleus. As a mechanism for the localization in cytoplasm, we first identified two nuclear export signals (NESs) in mCSS, based on the localization studies of the potential NES-deleted mCSS mutants as well as the potential NES-tagged eGFP proteins. These two NESs are conserved among mammalian and fish CSSs, but not present in the bacterial or insect CSS. These results suggest that the intracellular localization of vertebrate CSSs is regulated by not only the NLS, but also the NES sequences

  14. CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localization

    International Nuclear Information System (INIS)

    Neyton, Sophie; Lespinasse, Francoise; Lahaye, Francois; Staccini, Pascal; Paquis-Flucklinger, Veronique; Santucci-Darmanin, Sabine

    2007-01-01

    MSH4 and MSH5 are members of the MutS homolog family, a conserved group of proteins involved in DNA mismatch correction and homologous recombination. Although several studies have provided compelling evidences suggesting that MSH4 and MSH5 could act together in early and late stages of meiotic recombination, their precise roles are poorly understood and recent findings suggest that the human MSH4 protein may also exert a cytoplasmic function. Here we show that MSH4 is present in the cytoplasm and the nucleus of both testicular cells and transfected somatic cells. Confocal studies on transfected cells provide the first evidence that the subcellular localization of MSH4 is regulated, at least in part, by an active nuclear export pathway dependent on the exportin CRM1. We used deletion mapping and mutagenesis to define two functional nuclear export sequences within the C-terminal part of hMSH4 that mediate nuclear export through the CRM1 pathway. Our results suggest that CRM1 is also involved in MSH5 nuclear export. In addition, we demonstrate that dimerization of MSH4 and MSH5 facilitates their nuclear localization suggesting that dimerization may regulate the intracellular trafficking of these proteins. Our findings suggest that nucleocytoplasmic traffic may constitute a regulatory mechanism for MSH4 and MSH5 functions

  15. Efficiency defense and administrative fuzziness in merger regulation

    Czech Academy of Sciences Publication Activity Database

    Medvedev, Andrei

    -, č. 234 (2004), s. 1-42 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z7085904 Keywords : merger regulation * efficiency defense Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp234.pdf

  16. Local Commune Administration as a Regulator of the Local Water Supply and Sewage Disposal Services Market

    OpenAIRE

    Małysko, Jacek

    2012-01-01

    In this article the author discusses problems related to the regulation of water and sewage disposal services market. In the beginning he describes the processes of water supply and sewage disposal taken by the local commune administration as a natural monopoly. Next he characterizes the structure of this market in Poland. Then he presents the role of local commune administration as a regulator. The author concludes by evaluating the existing Polish system of regulating wate...

  17. Environmental impact statement law and environmental impact statement administration regulation

    International Nuclear Information System (INIS)

    Feldmann, F.J.

    1991-01-01

    The contribution does not deal with the question - as might be suggested by the heading - that the execution of the environmental impact statement law might be uncertain if there are no further accompanying legal transformatory acts. Putting the environmental impact statements into action is concerned in partiuclar with procedural provisions regarding the Federal Act on Protection against Nuisances and the Atomic Energy Act. The author deals with aspects of the environmental impact statement law and the state-of-the-art achieved so far. He also deals with legislative intent, with further points of putting the law into practice, i.e. the information requirements in the administrative provisions and the integrating aspect, the amalgamating aspect, the requirements made on the state of the environment, and the significance of administrative provisions. Also treated are legal procedures in the Federal Laender and on an international level. (RST) [de

  18. 7 CFR 800.16 - Certification requirements for export grain.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Certification requirements for export grain. 800.16 Section 800.16 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL...

  19. Export spillovers

    DEFF Research Database (Denmark)

    Choquette, Eliane; Meinen, Philipp

    2015-01-01

    This paper studies the importance of export spillovers in a firm's decision to enter specific export markets and extends the current state of the literature by assessing different mechanisms through which they may occur, namely (i) labour movement, (ii) intra-industry spillovers and (iii) inter......-industry linkages. We do so by exploiting a unique data set covering the universe of manufacturing firms in Denmark for the period 1995–2006 which combines transaction-level export data, firm accounting data, employer–employee linked data and information from yearly input–output tables. We corroborate...... the literature on export spillovers by presenting robust evidence of destination-specific export spillovers. The results suggest that labour mobility as well as intra- and inter-industry linkages (backward linkages) are important channels for export spillovers, while presenting heterogeneous effects across firms...

  20. Export strategy

    DEFF Research Database (Denmark)

    Knudsen, Thorbjørn; Koed Madsen, Tage

    2002-01-01

    It is argued here that traditional export strategy research (encompassing the study of internationalization processes and export performance) is characterized by weak theoretical foundations and could benefit from a reorientation towards a dynamic capabilities perspective (DCP). We seek to draw...... on insights from DCP in order to devise a theoretical basis that could enrich export strategy research. Although our development of DCP insights builds on previous work, it also adds a crucial distinction between knowledge stocks and informational architecture. Changes in architecture are of greater...... importance. Following this elaboration of the dynamic capabilities perspective, we outline some implications and guidelines for future export strategy research....

  1. 77 FR 72324 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-12-05

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 85-17A18] Export Trade Certificate of Review ACTION: Notice of Application to Amend the Export Trade Certificate of Review Issued to... to amend an Export [[Page 72325

  2. Radiopharmaceutical regulation and Food and Drug Administration policy.

    Science.gov (United States)

    Rotman, M; Laven, D; Levine, G

    1996-04-01

    The regulatory policy of the Food and Drug Administration (FDA) on radiopharmaceuticals flows from a rigid, traditional, drug-like interpretation of the FDC Act on the licensing of radiopharmaceuticals. This contributes to significant delays in the drug-approval process for radiopharmaceuticals, which are very costly to the nuclear medicine community and the American public. It seems that radiopharmaceuticals would be better characterized as molecular devices. Good generic rule-making principles include: use of a risk/benefit/cost analysis; intent based on sound science; performance standards prepared by outside experts; a definite need shown by the regulatory agency; to live with the consequences of any erroneous cost estimates; and design individual credential requirements so that additional training results in enhanced professional responsibility. When these common elements are applied to current FDA policy, it seems that the agency is out of sync with the stated goals for revitalizing federal regulatory policies as deemed necessary by the Clinton administration. Recent FDA rulings on positron-emission tomography, Patient Package inserts, and on medical device service accentuate the degree of such asynchronization. Radiopharmaceutical review and licensing flexibility could be dramatically improved by excluding radiopharmaceuticals from the drug category and reviewing them as separate entities. This new category would take into account their excellent record of safety and their lack of pharmacological action. Additionally, their evaluation of efficacy should be based on their ability to provide useful scintiphotos, data, or responses of the physiological system it portends to image, quantitate, or describe. To accomplish the goal of transforming the FDA's rigid, prescriptive policy into a streamlined flexible performance-based policy, the Council on Radionuclides and Radiopharmaceuticals proposal has been presented. In addition, it is suggested that the United

  3. 76 FR 78933 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2011-12-20

    ..., electronic record requirements, and investigator initiated research. Topics for discussion include the...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Clinical Research Associates (SoCRA), is announcing a public workshop. The public workshop on FDA's...

  4. Oral Administration of N-Acetyl-D Glucosamine Polymer Particles Down-Regulates Airway Allergic Responses

    National Research Council Canada - National Science Library

    Shibata, Yoshimi

    2006-01-01

    ... (IL-12, IL-18 and TNFo) that down-regulate allergic immune responses. We also found that administration of chitin particles resulted in less likely induce the production of IL-10 and prostaglandin E2 (PGE2...

  5. 77 FR 15370 - General Services Administration Acquisition Regulation; Information Collection; Price Reductions...

    Science.gov (United States)

    2012-03-15

    ... Services Administration Acquisition Regulation; Information Collection; Price Reductions Clause; Extension... notice of request for comments regarding OMB Control No. 3090-0235, Price Reductions Clause, published in... 16, 2012. ADDRESSES: Submit comments identified by Information Collection 3090- 0235, Price...

  6. Regulation of RNA-binding proteins affinity to export receptors enables the nuclear basket proteins to distinguish and retain aberrant mRNAs.

    Science.gov (United States)

    Soheilypour, M; Mofrad, M R K

    2016-11-02

    Export of messenger ribonucleic acids (mRNAs) into the cytoplasm is a fundamental step in gene regulation processes, which is meticulously quality controlled by highly efficient mechanisms in eukaryotic cells. Yet, it remains unclear how the aberrant mRNAs are recognized and retained inside the nucleus. Using a new modelling approach for complex systems, namely the agent-based modelling (ABM) approach, we develop a minimal model of the mRNA quality control (QC) mechanism. Our results demonstrate that regulation of the affinity of RNA-binding proteins (RBPs) to export receptors along with the weak interaction between the nuclear basket protein (Mlp1 or Tpr) and RBPs are the minimum requirements to distinguish and retain aberrant mRNAs. Our results show that the affinity between Tpr and RBPs is optimized to maximize the retention of aberrant mRNAs. In addition, we demonstrate how the length of mRNA affects the QC process. Since longer mRNAs spend more time in the nuclear basket to form a compact conformation and initiate their export, nuclear basket proteins could more easily capture and retain them inside the nucleus.

  7. 7 CFR 923.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 923.15 Section 923.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... IN WASHINGTON Order Regulating Handling Definitions § 923.15 Export. Export means to ship cherries...

  8. 7 CFR 958.14 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 958.14 Section 958.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.14 Export. Export...

  9. 7 CFR 945.14 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 945.14 Section 945.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 945.14 Export. Export...

  10. 7 CFR 948.17 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 948.17 Section 948.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 948.17 Export. Export means the shipment of potatoes to any destination...

  11. 7 CFR 915.12 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 915.12 Section 915.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 915.12 Export. Export means to ship avocados to any destination which is...

  12. 7 CFR 922.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 922.15 Section 922.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON Order Regulating Handling Definitions § 922.15 Export. Export means to ship apricots beyond the...

  13. 7 CFR 946.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 946.15 Section 946.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 946.15 Export. Export means shipment of potatoes beyond the boundaries of...

  14. 7 CFR 927.12 - Export market.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export market. 927.12 Section 927.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 927.12 Export market. Export market means any destination which...

  15. 7 CFR 924.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 924.15 Section 924.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.15 Export. Export means...

  16. 77 FR 6985 - General Services Administration Acquisition Regulation; Reinstatement of Coverage Pertaining to...

    Science.gov (United States)

    2012-02-10

    ... Acquisition Regulation; Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building... Administration Acquisition Regulation (GSAR) to restore guidance on the release of claims after completion of construction and building service contracts to ensure contractors are paid in accordance with their contract...

  17. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  18. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export

    DEFF Research Database (Denmark)

    Kjølby, Mads Fuglsang; Andersen, Olav Michael; Breiderhoff, Tilman

    2010-01-01

    of lipoproteins from the liver and ameliorates hypercholesterolemia and atherosclerotic lesion formation in LDL receptor-deficient animals. In contrast, sortilin overexpression stimulates hepatic release of lipoproteins and increases plasma LDL levels. Our data have uncovered a regulatory pathway in hepatic...... lipoprotein export and suggest a molecular explanation for the cardiovascular risk being associated with 1p13.3. Udgivelsesdato: september 8...

  19. Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

    International Nuclear Information System (INIS)

    Claudiani, Pamela; Riano, Elena; Errico, Alessia; Andolfi, Gennaro; Rugarli, Elena I.

    2005-01-01

    Most cases of autosomal-dominant hereditary spastic paraplegia are linked to mutations in SPG4 encoding spastin, a protein involved in microtubule dynamics and membrane trafficking. In pyramidal neurons of the motor cortex and in immortalized motor neurons, spastin is localized to the synaptic terminals and growth cones. However, in other neurons and in proliferating cells spastin is prevalently nuclear. The mechanisms that determine targeting of spastin to the nucleus or the cytoplasm are unknown. We show here that the SPG4 mRNA is able to direct synthesis of two spastin isoforms, 68 and 60 kDa, respectively, through usage of two different translational start sites. Both isoforms are imported into the nucleus, but the 68-kDa isoform contains two nuclear export signals that efficiently drive export to the cytoplasm. Nuclear export is leptomycin-B sensitive. The cytoplasmic 68-kDa spastin isoform is more abundant in the brain and the spinal cord than in other tissues. Our data indicate that spastin function is modulated through usage of alternative translational start sites and active nuclear import and export, and open new perspectives for the pathogenesis of hereditary spastic paraplegia

  20. 7 CFR 20.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 20.2 Section 20.2 Agriculture Office of the Secretary of Agriculture EXPORT SALES REPORTING REQUIREMENTS § 20.2 Administration. The regulations of this part will be administered by the Foreign Agricultural Service (FAS) under the general...

  1. Import and export of small quantities of nuclear materials

    International Nuclear Information System (INIS)

    Grenier, M.

    1986-06-01

    Administrative procedures for import export of nuclear materials are specific for each country. In France regulations are reviewed for small quantities, lower threshold, in some cases, allows a simplified procedure, however thresholds are not the same in the different texts (and for one of them, concerning proliferation, is zero). It is obvious that regulations are necessary even for small quantities but national and international threshold should be harmonized [fr

  2. 21 CFR 1312.23 - Issuance of export permit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Issuance of export permit. 1312.23 Section 1312.23... CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.23 Issuance of export permit. (a) The... regulation in § 1312.30 of this part be exported only pursuant to the issuance of an export permit. The...

  3. Effects of RoHs and REACH regulations on firm-level production and export, and the role of global value chains : the cases of Malaysia and Vietnam

    OpenAIRE

    Otsuki, Tsunehiro; Honda, Keiichiro; Michida, Etsuyo; Nabeshima, Kaoru; Ueki, Yasushi

    2015-01-01

    This paper uses firm-level data to examine the impact of foreign chemical safety regulations such as RoHS and REACH on the production costs and export performance of firms in Malaysia and Vietnam. This paper also investigates the role of global value chains in enhancing the likelihood that a firm complies with RoHS and REACH. We find that in addition to the initial setup costs for compliance, EU RoHS (REACH) implementation imposes on firms additional variable production costs by requiring add...

  4. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    Science.gov (United States)

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  5. Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450

    OpenAIRE

    Vinchi, Francesca; Ingoglia, Giada; Chiabrando, Deborah; Mercurio, Sonia; Turco, Emilia; Silengo, Lorenzo; Altruda, Fiorella; Tolosano, Emanuela

    2014-01-01

    Background & Aims The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural products, hormones, drugs, and carcinogens. Feline leukemia virus subgroup C cellular receptor 1a (FLVCR1a) is plasma membrane heme exporter that is ubiquitously expressed and controls intracellular heme content in hematopoietic lineages. We inv...

  6. Organizing export strategies.

    OpenAIRE

    G. Lojacono; M. Venzin

    2014-01-01

    The article unfolds as follows: after a brief introduction on the relevance of international trade and the characteristics of export strategies, we describe four distinct archetypes: export manager, centralistic export developer, export skimmer, integrated export developer.

  7. 75 FR 12433 - National Export Initiative

    Science.gov (United States)

    2010-03-16

    ... Order 13534 of March 11, 2010 National Export Initiative By the authority vested in me as President by... performance will, in turn, create good high-paying jobs. The National Export Initiative (NEI) shall be an Administration initiative to improve conditions that directly affect the private sector's ability to export. The...

  8. Administration

    DEFF Research Database (Denmark)

    Bogen handler om den praksis, vi kalder administration. Vi er i den offentlige sektor i Danmark hos kontorfolkene med deres sagsmapper, computere, telefoner,, lovsamlinger,, retningslinier og regneark. I bogen udfoldes en mangfoldighed af konkrete historier om det administrative arbejde fra...... forskellige områder i den offentlige sektor. Hensigten er at forstå den praksis og faglighed der knytter sig til det administrative arbejde...

  9. Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications

    OpenAIRE

    Shen, Liang; Liu, Lu; Ji, Hong-Fang

    2017-01-01

    ABSTRACT Curcumin, the major active component of turmeric (Curcuma longa), is widely used as a spice and food-coloring agent, and also exhibits multiple biological activities. However, as curcumin has poor systemic bioavailability its pharmacology remains to be elucidated. Owing to the high concentration of curcumin in the gastrointestinal tract after oral administration, we hypothesize that it may exert regulative effects on the gut microbiota. We investigated the regulative effects of oral ...

  10. 7 CFR 959.18 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 959.18 Section 959.18 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 959.18 Export. Export means to ship onions to any destination which is not within...

  11. 7 CFR 966.18 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 966.18 Section 966.18 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 966.18 Export. Export means shipment of tomatoes beyond the boundaries of the 48...

  12. 7 CFR 51.912 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Export. 51.912 Section 51.912 Agriculture Regulations... Standards for Grades of Table Grapes (European or Vinifera Type) 1 Definitions § 51.912 Export. When designated as Export, grapes shall be packed with any of the customary protective materials such as cushions...

  13. 22 CFR 120.17 - Export.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except by...

  14. 7 CFR 947.17 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 947.17 Section 947.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Definitions § 947.17 Export. Export means shipment of potatoes beyond the boundaries of continental United...

  15. A study in improvement of administrative system in the nuclear safety regulation

    International Nuclear Information System (INIS)

    Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho

    2001-03-01

    One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents

  16. A study in improvement of administrative system in the nuclear safety regulation

    Energy Technology Data Exchange (ETDEWEB)

    Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho [Chungnam National Univ., Taejon (Korea, Republic of)

    2001-03-15

    One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents.

  17. 78 FR 27239 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2013-05-09

    ... Services Administration Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales... Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial funding fee and sales reporting. A notice was published in the...

  18. 75 FR 13129 - General Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice...

    Science.gov (United States)

    2010-03-18

    ... Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice Format--Supplies and/or Services With an Established Catalog Price and Sales Practices Format-- Supplies and/or... will be submitting to the Office of Management and Budget (OMB) a request to review and approve a new...

  19. 75 FR 14448 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2010-03-25

    ... requirements, and investigator initiated research. Topics for discussion include the following: (1) What FDA...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Society of Clinical Research Associates, Inc. (SoCRA) is announcing a public workshop entitled ``FDA...

  20. 77 FR 8886 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2012-02-15

    ..., electronic record requirements, and investigator initiated research. Topics for discussion include the...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Research Associates (SoCRA) is announcing a public workshop. The public workshop on FDA's clinical trial...

  1. 76 FR 51040 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2011-08-17

    ... requirements, and investigator initiated research. Topics for discussion include the following: (1) What FDA...] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical... Clinical Research Associates (SoCRA) is announcing a public workshop. The public workshop on FDA's clinical...

  2. Administrative procedures for regulating construction and operation of nuclear power plants

    International Nuclear Information System (INIS)

    Cochaud, J.P.

    1981-01-01

    This article first explains that nuclear power plants in France are governed by a complex system of regulations within the framework of different laws concerning, in particular, protection of the environment, public health and workers. It then examines the administrative procedures and the licensing regime for nuclear power plants. (NEA) [fr

  3. 77 FR 58380 - General Services Administration Acquisition Regulation; Submission for OMB Review; Price...

    Science.gov (United States)

    2012-09-20

    ...] General Services Administration Acquisition Regulation; Submission for OMB Review; Price Reductions Clause... requirement regarding the GSAR Price Reductions Clause. A notice was published in the Federal Register at 76... identified by Information Collection 3090- 0235, Price Reduction Clause, by any of the following methods...

  4. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

  5. 75 FR 28632 - Federal Housing Administration (FHA)-Temporary Exemption From Compliance With FHA's Regulation on...

    Science.gov (United States)

    2010-05-21

    ... Housing Administration (FHA)--Temporary Exemption From Compliance With FHA's Regulation on Property... by the seller and the seller does not come under any of the exemptions to this 90-day period that are... objective of increasing the availability of affordable homes for first- time and other purchasers and...

  6. Export Controls: Controls Over the Export Licensing Process for Chemical and Biological Items

    National Research Council Canada - National Science Library

    2005-01-01

    .... foreign policy should read this report. The report discusses the effectiveness of the DoD review process for export license applications and updates to Federal export regulations to prevent the proliferation of items that could pose...

  7. Risk regulation and deliberation in EU administrative governance: GMO regulation and its reform

    NARCIS (Netherlands)

    Weimer, M.

    2015-01-01

    The article analyses the problems of EU risk regulation of genetically modified organisms (GMOs) through the lens of deliberative theories of EU law and governance, such as deliberative supranationalism and experimentalist governance. Previous research had suggested that the GMO issue is not

  8. 77 FR 5387 - Amendment to the Export Administration Regulations: Addition of a Reference to a Provision of the...

    Science.gov (United States)

    2012-02-03

    ... imposition of sanctions under the ISA. There are several possible sanctions that may be imposed under the ISA... three statutory authorities: (1) The Iran-Iraq Arms Nonproliferation Act of 1992 (Pub. L. 102-484); (2) the Iran, North Korea, and Syria Nonproliferation Act (Pub. L. 106-178); or (3) Section 11B(b)(1)(B)(i...

  9. 75 FR 14335 - Revisions to the Export Administration Regulations To Enhance U.S. Homeland Security: Addition of...

    Science.gov (United States)

    2010-03-25

    ... Division, Office of Nonproliferation and Treaty Compliance, telephone: (202) 482-4563. SUPPLEMENTARY... foreign policy report was submitted to Congress on March 19, 2010, notifying Congress of the imposition of...

  10. 76 FR 80282 - Revisions to the Export Administration Regulations (EAR): Control of Vessels of War and Related...

    Science.gov (United States)

    2011-12-23

    ... would require licenses from both the State Department and the Commerce Department. Following the... further align the CCL with the WAML and the Missile Technology Control Regime Equipment, Software and... antiterrorism (AT Column 1) controls, which currently impose a license requirement for five countries. A license...

  11. 75 FR 36511 - Revisions to the Export Administration Regulations Based Upon a Systematic Review of the Commerce...

    Science.gov (United States)

    2010-06-28

    ... overhaul of commercial aircraft engines, components and systems) paragraph (a), this rule updates the... control interests in a distributed computing environment. Also in Sec. 740.7, this rule revises the... Based Upon a Systematic Review of the Commerce Control List: Additional Changes AGENCY: Bureau of...

  12. 76 FR 54928 - Export Administration Regulations: Netherlands Antilles, Curaçao, Sint Maarten and Timor-Leste

    Science.gov (United States)

    2011-09-06

    ..., Bureau of Industry and Security, U.S. Department of Commerce at 202-482-2440 or by e-mail: Sharron.Cook... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 738, 740, 745, and 748 [Docket...[ccedil]ao, Sint Maarten and Timor-Leste AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final...

  13. 75 FR 56914 - Removal of the List of Ports of Embarkation and Export Inspection Facilities from the Regulations

    Science.gov (United States)

    2010-09-17

    ... farming operations, dairy cattle and milk production operations, hog and pig farming operations, sheep and goat farming operations, and cattle feedlots. The Small Business Administration has established...

  14. Prohibited or regulated? LSD psychotherapy and the United States Food and Drug Administration.

    Science.gov (United States)

    Oram, Matthew

    2016-09-01

    Over the 1950s and early 1960s, the use of the hallucinogenic drug lysergic acid diethylamide (LSD) to facilitate psychotherapy was a promising field of psychiatric research in the USA. However, during the 1960s, research began to decline, before coming to a complete halt in the mid-1970s. This has commonly been explained through the increase in prohibitive federal regulations during the 1960s that aimed to curb the growing recreational use of the drug. However, closely examining the Food and Drug Administration's regulation of LSD research in the 1960s will reveal that not only was LSD research never prohibited, but that the administration supported research to a greater degree than has been recognized. Instead, the decline in research reflected more complex changes in the regulation of pharmaceutical research and development. © The Author(s) 2016.

  15. 78 FR 53727 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-08-30

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-24A12] Export Trade Certificate of Review ACTION: Notice of Issuance of an Export Trade Certificate of Review to Northwest Fruit Exporters, Application No. 84-24A12. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade...

  16. 78 FR 1837 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-01-09

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-23A12] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Northwest Fruit Exporters, Application No. 84-23A12. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade...

  17. 78 FR 54238 - President's Export Council; Meeting

    Science.gov (United States)

    2013-09-03

    ... DEPARTMENT OF COMMERCE International Trade Administration President's Export Council; Meeting AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an open...; understanding best value in government procurement; de minimis reform; intellectual property protections in the...

  18. The Medicines (Administration of Radioactive Substances) Regulations 1978 (S.I. no.1006)

    International Nuclear Information System (INIS)

    1978-01-01

    These regulations prohibit the administration of radioactive medicinal products except by doctors or dentists holding a certificate issued by the Health Ministers for such purpose. They also lay down the procedure for the grant of such certificates and provide for the appointment of a Committee to advise the authorities on these matters. The Regulations were made in pursuance of Council Directive 76/579/Euratom which lays down the revised standards for the health protection of the general public and workers against the dangers of ionizing radiation. (NEA) [fr

  19. China: Possible Missile Technology Transfers from U.S. Satellite Export Policy - Actions and Chronology

    National Research Council Canada - National Science Library

    Kan, Shirley A

    2001-01-01

    .... Some critics opposed satellite exports to China, while others were concerned that the Clinton Administration relaxed export controls and monitoring of commercial satellites in moving the licensing...

  20. 7 CFR 35.8 - Date of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Date of export. 35.8 Section 35.8 Agriculture... Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.8 Date of export. Date of export means the date of loading on board the...

  1. 15 CFR 756.2 - Appeal from an administrative action.

    Science.gov (United States)

    2010-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS APPEALS... Industry and Security, U.S. Department of Commerce, Room 3898, 14th Street and Pennsylvania Avenue, NW... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeal from an administrative action...

  2. Case Law: - Canada: Criminal Court decision respecting attempted export of nuclear-related dual use items to Iran: Her Majesty the Queen vs Yadegari (2010); - Czech Republic: Supreme Administrative Court on the legal status of CEZ (2010)

    International Nuclear Information System (INIS)

    Anon.

    2010-01-01

    Case law 1: Canada - Criminal Court decision respecting attempted export of nuclear-related dual use items to Iran: Her Majesty the Queen vs Yadegari (2010). This case concerns a recent, successful prosecution that was undertaken before the Ontario Court of Justice relating to violations of export control legislation in Canada, nuclear regulatory legislation, customs law, criminal law, as well as Canadian law implementing UN Security Council resolutions concerning Iran. The convictions that have been registered in this case, notwithstanding the fact that the decision is currently under appeal,2 demonstrate the importance of a functioning export control regime and effective counter-proliferation strategy. The case represents the first conviction for a regulatory offense under the Nuclear Safety and Control Act,3 in force since 2000, and Mr. Yadegari is the first Canadian to be convicted under the United Nations Act, Canada's legislation by which it implements UN resolutions. Case law 2: Czech Republic - Supreme Administrative Court on the legal status of CEZ (2010). The Supreme Administrative Court in its decision of 6 October 20098 ruled on whether CEZ, a.s., which is the operator of nuclear installations at the Temelin and Dukovany sites in the Czech Republic, is governed by the Act on Free Access to Information. The court stated that the rules laid down in the Act on Free Access to Information, also apply to CEZ which is considered as a 'public institution'. The following reasons led the court to this interpretation: first, CEZ was established by decision of the state in the course of the privatisation process. Secondly, the company is effectively controlled by the state, which is still its majority owner and the profits of the company also compose a portion of state budget revenues. Finally, there is a public interest served in the function of the company

  3. An evaluation of Kazakhstan nuclear export control system

    International Nuclear Information System (INIS)

    Yeligbayeva, G.; Masenov, Ch.

    2002-01-01

    A system to control the export nuclear materials and technologies is a natural part of creating a self-sustaining government. The government of Kazakhstan has made a great deal of progress in building such a system. Control of export and import of nuclear materials and technologies and dual-use materials, related to nuclear activity, became one of the important part of mechanism of Non-Proliferation conditions realization in Kazakhstan. The system of export control has developed well over the 10 years. Kazakhstan is in the midst of a long process of building a functional export control system consistent with World standards. The state system of export control currently exists in Kazakhstan on the legislative base, and is based on efficient cooperation of the KAEC with a number of competent state bodies (Ministry of Economy, Ministry of Foreign Affairs, State Customs Committee) each of them has its own specific functions, duties and rights. The export is carried out using licenses, issued by the Ministry of Economy of the RK, according to applications of certain standard which are previously agreed with the KAEC under decision of the RK Government. The KAEC, acting on the base of export control principles and observance of international obligations on non-proliferation matter, makes decisions, only after thorough evaluation of ways of export and reliability of an end-user of the commodity, to agree the application for a license. The most fully developed aspect is the licensing process. General politics of export regulation in Kazakhstan are based on normative acts and rules, which are wholly appropriate (complementary) to the managing principles of nuclear export. There exists a full legal basis for the licensing system. But the process is going, some provisions is changing: in 2000 Kazakhstan corrected the export control law and approved the national control list very similar with EU control list, in 2002 the rules of the process of licensing the export and import

  4. Outline of safety regulations and administrations for commercial nuclear power plants in Japan

    International Nuclear Information System (INIS)

    Kinichi Yamamoto

    1987-01-01

    Outline of safety regulations and administrations for the commercial nuclear power plants in Japan is briefly described. The strict measures for safety assurance are always taken based on the principle of defense-indepth. In the actual procedures of regulatory control, the examinations and inspections shall be performed at each individual step in the stage of applications, and also in the stage of constructions. Thus, those regulatory examinations and inspections shall be performed in detail and carefully, and at the most suitable time; resulting in an effective regulatory control by the Ministry of International Trade and Industry. (author)

  5. US exports

    International Nuclear Information System (INIS)

    Schrage, W.E.

    1991-01-01

    This paper reports on the past, present, and future of US coal exports. It is expected that in the 1990's, the following factors will be evident: Significant increases in coal production and port capacity in Australia and South Africa, but little in Canada; Potentially significant increase in coal production and port capacity in Colombia, Venezuela and Indonesia; Continued movement away from subsidized indigenous coal production in Europe and Japan. A substantial growth in world coal trade; Stronger growth in energy demand in the 1990s than in the 1980s; Significantly fewer additions to nuclear generating capacity in the 1990s than in the 1980s; Reduced coal production in Eastern Europe from that of the 1980s; Greater caution will be exercised in putting in new coal production capacity

  6. 19 CFR 351.520 - Export insurance.

    Science.gov (United States)

    2010-04-01

    ... Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Identification and Measurement of Countervailable Subsidies § 351.520 Export insurance. (a) Benefit—(1) In general. In the case of export insurance, a benefit exists if the premium rates charged are inadequate to...

  7. Evaluation of the Navy Implementation of DOD Financial Management Regulation, Volume 14, Administrative Control of Funds and Antideficiency Act Violations

    National Research Council Canada - National Science Library

    Lane, F

    1996-01-01

    On August 1, 1995, the Under Secretary of Defense (Comptroller) released for implementation Financial Management Regulation, volume 14, "Administrative Control of Funds and Antideficiency Act Violations," August 1, 1995...

  8. Understanding the administrative regulation on occupational health and trend in China.

    Science.gov (United States)

    Zhou, Zhijun

    2018-03-27

    With the immense economic growth and social development, China has gained worldwide attention. With the quick growth of industrialization, several international professionals are gaining interest in occupational management system and in the role of the Chinese Government in protecting the worker's health. The Law on Prevention and Control of Occupational Diseases and the Work Safety Law are the two most important laws in China, which highlight the responsibilities of the employer, employee, governmental agencies, authorized occupational health service agency, and other stakeholders. The State Council comprises two departments, namely, the State Administration on Work Safety (SAWS) and the National Health and Family Planning Commission (NHFPC), which are responsible for governing the occupational health work. A series of regulations and standards have been promulgated by the Chinese Government to encourage or instruct the employers to fulfill their responsibility; however, several issues persist related to occupational health work, including administrative, technological, and sociocultural aspects. At present, the Chinese Government wants to enhance the reform in both economic and administrative structures, and the adjustments for modifying and/or improving the occupational health regulatory system are expected. Notably, the occupational health work in China must be altered for better.

  9. Radiation Protection Ordinance 1989. Supplement with Radiation Protection Register Ordinance, general administration regulation pursuant to Sect. 45 Radiation Protection Ordinance, general administration regulation pursuant to Sect. 62 sub-sect. radiation passport

    International Nuclear Information System (INIS)

    Veith, H.M.

    1990-01-01

    The addendum contains regulations issued supplementary to the Radiation Protection Ordinance: The Radiation Protection Register as of April 3, 1990 including the law on the setting up of a Federal Office on Radiation Protection; the general administration regulation pursuant to Sect. 45 Radiation Protection Ordinance as of February 21, 1990; the general administration regulation pursuant to Sect. 62 sub-sect. 2 Radiation Protection Ordinance as of May 3, 1990 (AVV Radiation passport). The volume contains, apart from the legal texts, the appropriate decision by the Bundesrat, the official explanation from the Bundestag Publications as well as a comprehensive introduction into the new legal matter. (orig.) [de

  10. Development of a Prototype for the Export Control List Management System

    International Nuclear Information System (INIS)

    Kim, GwanYoung

    2011-01-01

    The international society has concerned the possibility of a diversion with strategic items into the nuclear weapon development. So they have regulated those, and our country also has done it. Following a accomplishment of a UAE nuclear power plant export contraction in December, 2009 and a Jordan research reactor export contraction in March, 2010, thousands upon thousands of the strategic goods include the strategic technology will be supposed to transfer to UAE and Jordan. A lot of manpower in the government and the company concerned in addition to an enormous amount of time are needed so as to manage transferred items to UAE and Jordan efficiently. Accordingly, the Export Control List Management System has developed 1) to decrease the administrative time required about implementations such as the classification, the export license 2) and to plan the practical use of manpower 3) and to enhance a convenience of businesses, the government and a company concerned by the KINAC and the KOSTI. That system is scheduled to complete after June, and now a management of export items has done manually. This inconvenience can be solved by developing a prototype of the Export Control List Management System. Also an understanding of the Export Control List Management will be enhanced by doing it. A procedure of a system development and results will be presented in this paper

  11. Nuclear exports. Parliamentary control and confidentiality; Parlamentarische Kontrolle und Geheimhaltungsbeduerftigkeit bei Nuklearexporten. Zum Urteil des Bundesverfassungsgerichts vom 21. Oktober 2014

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2015-03-15

    With its decision taken on 21. October 2014 (Az.: 2 BvE 5/11) the Federal Constitutional Court (BVerfG) decided during court proceedings between administrative bodies on the scope and limits of the parliamentary right of information. Even though the proceeding did not deal with nuclear exports but arm exports, foreign trade law, however, does not only designate an export licence obligation for military weapons but also for so called dual-use goods meaning goods, which can be used both for friendly as well as for military purposes. The export of these goods requires according to the so-called Dual-Use Regulation (EG) 428/2009 a licence. Annex I category 0 of the regulation (EG) 428/2009 lists a variety of nuclear materials, plants and equipment items for which this licence applies. In the same manner as arm exports, also exports of nuclear dual-use goods are being discussed in a special cabinet committee, the Federal Security Council (BSR), which shall coordinate cross-departmentally the German security and defence policy under consideration of economic interests and which categorises its results, according to the rules of procedure, as confidential. Also legally not regulated but common ''preliminary enquiries'' at the responsible Federal Ministry or rather Federal Office of Economics and Export Control by companies which plan an export and want to affirm the general approval for their export business prior to conclusion of contract take not only place for arm exports but also for nuclear dual-use goods. The decision by the Federal Constitutional Court can be applied to consultations about the authorisation of nuclear dual-use goods.

  12. 78 FR 61953 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-08

    ... counsel, Gormley has indicated that he does not intend to contest BIS's decision to deny his export..., selling, delivering, storing, disposing of, forwarding, transporting, financing, or otherwise servicing in... Regulations that has been or will be exported from the United States, including financing or other support...

  13. 27 CFR 4.80 - Exports.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exports. 4.80 Section 4.80 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE General Provisions § 4.80 Exports. The regulations in...

  14. 77 FR 58809 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-09-24

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 12-00005] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Colombia Rice Export Quota, Inc. (``COL-RICE'') (Application 12-00005). SUMMARY: On August 28, 2012, the U.S...

  15. 77 FR 28853 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-05-16

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 10-2A001] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Alaska Longline... Export Trade Certificate of Review Alaska Longline Cod Commission (``ALCC'') on May 7, 2012. This is the...

  16. 77 FR 41970 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-07-17

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 12-00001] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Panama Poultry Export Quota, Inc. (``PAN-PEQ'') (Application 12-00001). SUMMARY: On June 25, 2012, the U.S. Department...

  17. 77 FR 53865 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-09-04

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 12-00004] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Colombia Poultry Export Quota, Inc. (``COLOM-PEQ)'') (Application 12-00004). SUMMARY: On August 14, 2012, the U.S...

  18. 78 FR 13861 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-03-01

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 85-17A18] Export Trade Certificate of Review ACTION: Notice of Issuance of an Amended Export Trade Certificate of Review to U.S..., Office of Competition and Economic Analysis (OCEA), has issued an amended Export Trade Certificate of...

  19. 77 FR 61744 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-10-11

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 10-3A001] Export Trade Certificate of Review ACTION: Notice of Issuance of an Export Trade Certificate of Review to Alaska Longline... Commerce issued an amended Export Trade Certificate of Review to the Alaska Longline Cod Commission (``ALCC...

  20. 77 FR 12562 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-03-01

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 10-2A001] Export Trade Certificate of Review ACTION: Notice of Application (10-2A001) to Amend the Export Trade Certificate of Review..., has received an application to amend an Export Trade Certificate of Review (``Certificate''). This...

  1. 78 FR 25060 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-04-29

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 92-11A001] Export Trade Certificate of Review ACTION: Notice of Issuance of an amended Export Trade Certificate of Review to Aerospace... issued an amended Export Trade Certificate of Review to Aerospace Industries Association of America on...

  2. 78 FR 30273 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-05-22

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-24A12] Export Trade Certificate of Review ACTION: Notice of Application to Amend the Export Trade Certificate of Review Issued to... application to amend an Export Trade Certificate of Review (``Certificate''). This notice summarizes the...

  3. 78 FR 31517 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-05-24

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 99-5A002] Export Trade Certificate of Review ACTION: Notice of Issuance of an amended Export Trade Certificate of Review to California Almond Export Association, LLC (``CAEA'') (Application 99-5A002). SUMMARY: The U.S. Department of...

  4. 75 FR 8040 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-02-23

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application 10-00001] Export Trade Certificate of Review ACTION: Notice of Application for an Export Trade Certificate of Review from Alaska Longline Cod Commission (``ALCC'') SUMMARY: The Export Trading Company Affairs (``ETCA'') unit, Office of...

  5. 78 FR 62585 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-10-22

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 89-5A018] Export Trade Certificate of Review ACTION: Notice of Application to amend the Export Trade Certificate of Review Issued to... received an application to amend an Export Trade Certificate of Review (``Certificate''). This notice...

  6. 77 FR 2036 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-01-13

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 92-10A001] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Aerospace... an amended Export Trade Certificate of Review to Aerospace Industries of America on September 27...

  7. 78 FR 36747 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-06-19

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 89-4A018] Export Trade Certificate of Review ACTION: Notice of Application to amend the Export Trade Certificate of Review Issued to... received an application to amend an Export Trade Certificate of Review (``Certificate''). This notice...

  8. 78 FR 72865 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-12-04

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 92-12A001] Export Trade Certificate of Review ACTION: Notice of application to amend the Export Trade Certificate of Review issued to..., has received an application to amend an Export Trade Certificate of Review (``Certificate''). This...

  9. 78 FR 36745 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-06-19

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 87-9A001] Export Trade Certificate of Review ACTION: Notice of Application to amend the Export Trade Certificate of Review Issued to..., has received an application to amend an Export Trade Certificate of Review (``Certificate''). This...

  10. 78 FR 59004 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-09-25

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 13-00001] Export Trade Certificate of Review ACTION: Notice of Application for an Export Trade Certificate of Review to Emporia Trading LLC, Application No. 13-00001. SUMMARY: The Export Trading Company Affairs (``ETCA'') unit, Office...

  11. 78 FR 78818 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-12-27

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 13-00001] Export Trade Certificate of Review ACTION: Notice of Issuance of an Export Trade Certificate of Review to Emporia Trading LLC, Application No. 13-00001. SUMMARY: The U.S. Department of Commerce issued an Export Trade...

  12. 78 FR 78816 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-12-27

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 87-9A001] Export Trade Certificate of Review ACTION: Notice of Issuance of an Amended Export Trade Certificate of Review to... issued an amended Export Trade Certificate of Review to Independent Film and Television Alliance (``IFTA...

  13. 78 FR 5778 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-01-28

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 92-11A01] Export Trade Certificate of Review ACTION: Notice of Application (92-11A01) to amend the Export Trade Certificate of Review... of Commerce, has received an application to amend an Export Trade Certificate of Review...

  14. Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.

    Directory of Open Access Journals (Sweden)

    Hyung Jin Choi

    Full Text Available Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days. Rats were divided into control, ghrelin ad libitum-fed (ghrelin ad lib-fed, and ghrelin pair-fed groups. Ghrelin intracerebroventricular infusion significantly increased body weight in ghrelin ad lib-fed rats but not in ghrelin pair-fed rats, as compared with control rats. Chronic intracerebroventricular ghrelin infusion significantly increased bone mass in the ghrelin pair-fed group compared with control as indicated by increased bone volume percentage, trabecular thickness, trabecular number and volumetric bone mineral density in tibia trabecular bone. There was no significant difference in trabecular bone mass between the control group and the ghrelin ad-lib fed group. Chronic intracerebroventricular ghrelin infusion significantly increased the mineral apposition rate in the ghrelin pair-fed group as compared with control. In conclusion, chronic central administration of ghrelin increases bone mass through a mechanism that is independent of body weight, suggesting that ghrelin may have a bone anabolic effect through the central nervous system.

  15. Counterproliferation, Border Security and Counterterrorism Subject-Related Laws and Regulations, Including Export Control Regimes in South-Eastern European Countries

    International Nuclear Information System (INIS)

    Bokan, S.

    2007-01-01

    gaps exist, much less fill them. All this suggests that, to fulfil obligations under UNSC Resolutions 1540 and 1373, States must enact harmonized criminal prohibitions and authorization for law enforcement cooperation in order to establish a seamless web of security among all nations. Failure to do so implicitly poses a threat to international peace and security. One of the main issues which deserve to be further addressed and which prompts the continuation of the Southeast Europe Counterproliferation, Borger Security and Counterterrorism (CBSC) Working Group is to harmonize national laws and regulations that deal with deterring, detecting and interdicting WMD. Inventory of relevant CBSC subject-related laws of the Southeast Europe countries, including Export Control Laws was created and prepared for further consideration and harmonization by judiciary experts, with the aim to develop m odel laws . Let me very briefly present you the main features of the SEDM CBSC subject-related laws and regulations. This paper will present that inventory which includes the membership in the international Conventions, Treaties and Arrangements and also the membership in Multilateral Export Control Regimes of Southeast Europe countries. Also, it will be presented the membership in the international legal instruments that play an integral part in the global fight against terrorism. (author)

  16. Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration.

    Science.gov (United States)

    Feng, Ru; Zhao, Zhen-Xiong; Ma, Shu-Rong; Guo, Fang; Wang, Yan; Jiang, Jian-Dong

    2018-01-01

    Berberine (BBR) is considered a multi-target drug that has significant advantages. In contrast to its significant pharmacological effects in clinic, the plasma level of BBR is very low. Our previous work revealed that dihydroberberine (dhBBR) could be an absorbable form of BBR in the intestine, and butyrate is an active metabolite that is generated by gut bacteria in rats. In this study, for the first time we describe gut microbiota-regulated pharmacokinetics in beagle dogs after oral administration of BBR by single (50 mg/kg) or multiple doses (50 mg/kg/d) for 7 days. GC-MS, GC, LC-MS/MS, and LC/MS n -IT-TOF were used to detect dhBBR, butyrate and BBR as well as its Phase I and II metabolites, respectively. The results showed that dhBBR was not detected in dog plasma but was excreted in small amounts in the feces of dogs examined on days 3 and 7. Butyrate was generated by gut bacteria and increased by 1.3- and 1.2-fold in plasma or feces, respectively, after 7 days of BBR treatment compared to the levels before treatment. Changes of intestinal bacterial composition were analyzed by 16S rRNA genes analysis. The results presented that dogs treated with BBR for 7 days increased both the abundance of the butyrate- and the nitroreductases- producing bacteria. We also identified chemical structures of the Phase I and II metabolites and analyzed their contents in beagle dogs. Eleven metabolites were detected in plasma and feces after BBR oral administration (50 mg/kg) to dogs, including 8 metabolites of Phase I and III metabolites of Phase II. The pharmacokinetic profile indicated that the concentration of BBR in plasma was low, with a C max value of 36.88 ± 23.45 ng/mL. The relative content of glucuronic acid conjugates (M11) was higher than those of other metabolites (M1, M2, M12, and M14) in plasma. BBR was detected in feces, with high excreted amounts on day 3 (2625.04 ± 1726.94 μg/g) and day 7 (2793.43 ± 488.10 μg/g). In summary, this is the first study to

  17. Export and import provisions for nuclear materials and power plants, from the legal point of view

    International Nuclear Information System (INIS)

    Shapar, H.K.

    1975-01-01

    This paper provides a general review of the legal bases for and the administrative procedures involved in the export and import licensing of nuclear power reactors, fuels, and other nuclear materials by the United States. The basic statutory provisions and requirements are briefly described, and the requirement of an agreement for cooperation reviewed. The regulations of the Nuclear Regulatory Commission are covered in greater detail as they apply to the export and import of power reactors, nuclear fuels, source materials and byproduct materials. The intra-governmental procedures for review of an application for an export license are described in detail. Problems encountered in the administration of the law and regulations are described and the methods of resolving them are noted. The paper concludes with a brief account of three current topics, 1) the preparation of an environmental impact statement for export programs, 2) the situation with respect to the export licensing of component parts of reactors by the U.S. Department of Commerce, and 3) the shipment of plutonium by air. (orig.) [de

  18. Relationships between the ABC-exporter HetC and peptides that regulate the spatiotemporal pattern of heterocyst distribution in Anabaena.

    Directory of Open Access Journals (Sweden)

    Laura Corrales-Guerrero

    Full Text Available In the model cyanobacterium Anabaena sp. PCC 7120, cells called heterocysts that are specialized in the fixation of atmospheric nitrogen differentiate from vegetative cells of the filament in the absence of combined nitrogen. Heterocysts follow a specific distribution pattern along the filament, and a number of regulators have been identified that influence the heterocyst pattern. PatS and HetN, expressed in the differentiating cells, inhibit the differentiation of neighboring cells. At least PatS appears to be processed and transferred from cell to cell. HetC is similar to ABC exporters and is required for differentiation. We present an epistasis analysis of these regulatory genes and of genes, hetP and asr2819, successively downstream from hetC, and we have studied the localization of HetC and HetP by use of GFP fusions. Inactivation of patS, but not of hetN, allowed differentiation to proceed in a hetC background, whereas inactivation of hetC in patS or patS hetN backgrounds decreased the frequency of contiguous proheterocysts. A HetC-GFP protein is localized to the heterocysts and especially near their cell poles, and a putative HetC peptidase domain was required for heterocyst differentiation but not for HetC-GFP localization. hetP is also required for heterocyst differentiation. A HetP-GFP protein localized mostly near the heterocyst poles. ORF asr2819, which we denote patC, encodes an 84-residue peptide and is induced upon nitrogen step-down. Inactivation of patC led to a late spreading of the heterocyst pattern. Whereas HetC and HetP appear to have linked functions that allow heterocyst differentiation to progress, PatC may have a role in selecting sites of differentiation, suggesting that these closely positioned genes may be functionally related.

  19. On Administrative Regulation Mode of Surrogacy%代孕的行政规制模式研究

    Institute of Scientific and Technical Information of China (English)

    刘长秋

    2013-01-01

    The choice of administrative regulation mode of surrogacy directly influences, and even decides, the effect of surrogacy regulation. At present, there are mainly three administrative regulation modes of surrogacy worldwide, which are completely prohibited mode, limited open mode and non-uniformly regulated mode. The completely prohibited mode adopted by China’s current administrative regulation concerning surrogacy doesn’t go against the basic principle of administrative regulation, and on the contrary, it is a reasonable administrative regulation mode respecting more of humanity, being fully conforming to China’s national conditions. However, out of the need to regulate surrogacy more effectively, China’s current surrogacy regulation needs to be further improved in system design.%代孕行政规制模式的选择,直接影响甚至决定着代孕规制的效果。目前,世界范围内主要有完全禁止型、有限开放型和非统一规制型三种代孕行政规制模式。我国现行行政规章对代孕所采取的完全禁止模式,并不违背行政规制的基本原则,相反,它是一种更尊重人性的且完全符合我国国情的合理的行政规制模式。然而,出于更有效规制代孕之需要,我国现行代孕规制在制度设计上还需要进一步完善。

  20. 75 FR 37742 - Addition of New Export Control Classification Number 6A981 Passive Infrasound Sensors to the...

    Science.gov (United States)

    2010-06-30

    ... Infrasound Sensors to the Commerce Control List of the Export Administration Regulations, and Related... control passive infrasound sensors because of their military and commercial utility. Items under this new... Thompson, Sensors and Aviation Division, Bureau of Industry and Security, Telephone: (202) 482-4252...

  1. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Science.gov (United States)

    2012-11-19

    ...; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD), General... collection requirement concerning cost accounting standards administration. Public comments are particularly... Information Collection 9000- 0129, Cost Accounting Standards Administration by any of the following methods...

  2. China's coal export and inspection

    International Nuclear Information System (INIS)

    Xiaodong Li

    1993-01-01

    With the development of world's business and trade, coal has become a large part of the import and export goods in the international market. The total amount of coal trade has risen a lot. China is rich in coal resources. According to the estimate made by some experts, the reserve which has been explored recently could be exploited hundreds of years. China's output of raw coal has risen a lot during the past forty years. China coal industry has developed rapidly since the 1980s. It is possible for China to become a big coal export country since it has rich resources and increasing output. The paper suggests four steps which must be taken to expand coal exports in China: improve the level of management and administration of coal mines so as to raise the economic benefit; the follow-up production capacity of the present mines must be enhanced rapidly; step up construction of new large-scale mines; and China's coal washing capacity must be improved speedily since the low capacity has seriously influenced the improvement of coal quality. The paper describes the inspection bureaus and companies that have developed to perform inspection of exports in order to guarantee the quality of export coal

  3. Nuclear export controls - Closing the gaps

    International Nuclear Information System (INIS)

    Schmidt, Fritz W.

    2005-01-01

    Concerns over a nuclear 'black market' have focused international attention on the effectiveness of nuclear export controls. IAEA Director General Mohamed ElBaradei has stated that the emergence of a multinational illicit network demonstrated the inadequacy of the present export control system, that international cooperation on export controls lay on informal arrangements that were not only not binding but also limited in membership, and that export control information was not systematically shared with the IAEA. This criticism, often heard on the political level, does not really do justice to the work of export control groups. The emergence of a multinational illicit network does not necessarily prove failures in export control systems. Criminal activities, by definition, try to circumvent existing rules and regulations, or they exploit the absence of such rules on State level. To fight such individual cases is not so much a task of regular export control systems, whose function lies primarily in establishing standards and procedures for export controls on State level, but rather the task for intelligence services and their international cooperation. The basis of the export control regime is the Nuclear Non-Proliferation Treaty (NPT). Export controls can - and do - play an important role in fostering this universality goal by demanding the implementation of internationally agreed security standards in recipient countries before export licenses are granted. Drawn from the deliberations in the NPT conferences, the current standards to be demanded as conditions of supply are the following: Safeguards, Physical Protection, National export control provisions. According to the NPT system, export controls require IAEA verification in the recipient country. In addition, export controls enable States to provide information to the IAEA on exports and imports as required by the Additional Protocol. The 2005 NPT Review Conference will be an opportunity to review developments

  4. 78 FR 12719 - President's Export Council: Meeting of the President's Export Council

    Science.gov (United States)

    2013-02-25

    ... deliberate on recommendations related to promoting the expansion of U.S. exports. Topics may include the Administration's ``Doing Business in Africa'' campaign, the need for nominations to the U.S. Export- Import Bank.../pec ) without change, including any business or personal information provided such as names, addresses...

  5. Safety and exportation of nuclear power stations

    International Nuclear Information System (INIS)

    Coudray, M.; Perrais, J.P.

    1976-01-01

    Safety problems arising from exportation are especially handled through the French exportation of PWR stations. Regulations differ widely from one country to another. However, very large use of American regulations is made and frequently there is a tendency to harden such or such clause in the quotation. Industry must be ready to give satisfaction to such demands of customers. Sometimes also, it is a mere duplication of French stations which is above all looked for. In that case, it is the problem of using French regulations abroad which arises. Desirable changes in examination proceedings are analyzed together with a French regulation effort aiming to make easier the promotion of their use abroad. Finally, safety may be a factor of success for exportation attempts. It is shown how useless some outbiddings may be, but also how, on the contrary, speeding up of research and development effort towards specific safety problems in case of exportation, is to be promoted [fr

  6. Administrative-legal regulation of causes and conditions determining corruption in social sphere

    Directory of Open Access Journals (Sweden)

    Aleksandr V. Polukarov

    2017-12-01

    Full Text Available Objective to show the capabilities of administrativelegal regulation for combating the causes and conditions determining corrupt behavior in the social sphere. Methods dialectic approach to cognition of social phenomena enabling to analyze them in historical development and functioning in the context of the totality of objective and subjective factors that determined the choice of the following research methods analysis synthesis comparison systematic formallegal comparativelegal methods. Results the reasons and conditions determining the corruption in the social sphere were disclosed this leads to the conclusion that corruption counteraction should be based on 1 recognition of the social sphere as the key object of protection against corruption 2 elaboration of special administrativelegal means of corruption counteraction in the social sphere. It is necessary to take into account the features of social relations in such sectors as education healthcare culture physical culture and sports etc. A number of foreign countries took the path of developing legislation on corruption counteraction taking into account the specifics of various social sphere segments functioning. This experience is quite interesting from the viewpoint of developing means of combating the causes and conditions that determine corruption in the social sphere. A number of the Russian Federation subjects also elaborate regional programs of combating corruption in education healthcare and culture. In our opinion this experience should be transferred to the federal level of legal regulation. This will help to create a fullfledged system of corruption counteraction in the social sphere taking into account different levels of its functioning. Scientific novelty for the first time in administrativelegal science the ldquolaw of torts aspect of corruption in the social sphererdquo issue is considered the work reveals the causes and conditions that determine corruption in the social

  7. Export and import provisions for nuclear materials and power plants

    International Nuclear Information System (INIS)

    Malsch, M.G.

    1976-01-01

    The present paper deals with 1) statutory requirements for export and import licensing of nuclear reactors and fuels; 2) regulations and procedures to issuance of exportlicenses; 3) environmental impact of export licensing; 4) licensing of reactor equipment; 5) recent restrictions on imports and exports of nuclear fuels. (RW) [de

  8. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Evaluation of Export....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision: Evaluation of Export Offers (JAN 2001) (a) Port handling and ocean charges—other than DOD water terminals...

  9. 48 CFR 552.211-87 - Export packing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Export packing. 552.211-87... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.211-87 Export packing. As prescribed in 511.204(b)(7), insert the following clause: Export Packing (JAN 2010) (a...

  10. Immigrant Entrepreneurs, Diasporas and Exports

    OpenAIRE

    Bratti, Massimiliano; De Benedictis, Luca; Santoni, Gianluca

    2018-01-01

    In this paper we highlight a new complementary channel to the business and social network effect à la Rauch (2001) through which immigrants generate increased export flows from the regions in which they settle to their countries of origin: they can become entrepreneurs. Using very small-scale (NUTS-3) administrative data on immigrants’ location in Italy, the local presence of immigrant entrepreneurs (i.e. firms owned by foreign-born entrepreneurs) in the manufacturing sector, and on trade ...

  11. Notice to exporters on products prohibited from export (nuclear material, equipment and large nuclear units)

    International Nuclear Information System (INIS)

    1988-01-01

    In order to ensure that the policy to avoid the proliferation of nuclear weapons is complied with, the French Administration applies stricter controls over the export of certain sensitive products, materials and equipment. To this effect, lists of such products, materials and equipment are published in the form of Notices to exporters and periodically revised. This Notice repeals and replaces the previous Notice published in the Official Gazette of 21 January 1986. Annex I contains the list of materials whose export is subject to nuclear non-proliferation controls. Annex II lists the equipment whose export is subject to the same controls. Annex III includes the list of large nuclear units for which an application for prior approval of export must be submitted to the Administrations concerned. (NEA) [fr

  12. Exports and Job Training

    OpenAIRE

    Bastos, Paulo; Silva, Joana; Proenca, Rafael

    2016-01-01

    This paper examines whether export participation matters for job training. The paper draws on longitudinal worker-firm data for Brazilian manufacturing, linked with detailed records on training activity from the main provider. The analysis uses industry-specific exchange rate movements to generate exogenous variation in export status at the firm-level. The findings indicate that export par...

  13. Exporting EU Liberalism Eastwards

    Directory of Open Access Journals (Sweden)

    Lynn M. Tesser

    2009-07-01

    Full Text Available There is much more to liberalism in the post communist context than has been acknowledged. A sizeable effort has indeed emerged to transplant a relatively coherent liberal ideology to the region, one exported not merely through the conditionality of international financial institutions, but also through the conditionality and socialization of organizations like the NATO, OSCE, EU, and the Council of Europe. ‘EU liberalism’ includes the ‘standard’ liberal emphasis on individual rights, the rule of law, constitutional democracy, freedom, and market economics as well as support for minority rights, and a seemingly schizophrenic emphasis on economic integration that involves, first bringing down borders for the free movement of people, goods, capital, and services between member states, and second, market regulation to diminish the social downsides of capitalism. This paper outlines EU liberalism’s emergence and its application to Central and East European countries.

  14. The influence of teacher perceived administration of self-regulated learning on students' motivation and information-processing

    NARCIS (Netherlands)

    Rozendaal, JS; Minnaert, A; Boekaerts, M

    This study investigates the influence of teacher perceived administration of self-regulated learning on students' motivation and information-processing over time. This was done in the context of the Interactive Learning group System (ILS (R)): a large-scale innovation program in Dutch vocational

  15. Renewable energy export network

    International Nuclear Information System (INIS)

    Anon

    2000-01-01

    A Renewable Energy Exporters Network (REEN) has recently been established, following a meeting of renewable energy exporters and government agencies on 30 October 2000. REEN will assist the Australian renewable energy industry to take advantage of the opportunities offered by the burgeoning global market for renewable energy goods and services. Recent estimates of the significant potential global growth is renewable energy demand have reinforced the industry and Government's view that, in the medium to long-term, growth in the Australian renewable energy industry will largely depend on capturing export market share. Expanding the export market was identified as a crucial component in the Renewable Energy Action Agenda, developed jointly by industry and Government and released in June 2000. It was estimated that, for the industry to achieve its vision of sales of $4 billion per year by 2010, exports would need to comprise approximately 50% of the forecast growth in sales. As such, the need for a specific export strategy for the Australian renewable energy industry was recognised in the Action Agenda, and the establishment of the REEN is one of the first initiatives undertaken as part of the Renewable Energy Export Strategy. The REEN comprises approximately 50 export-ready renewable energy companies, the Department of Industry, Science and Resources, Austrade, and Stage Government agencies such as NSW's Sustainable Energy Development Authority. The Export Network will operate electronically, with face-to-face meetings held as appropriate. The Department of Industry, Science and Resources will facilitate the Export Network and has published a website at www.isr.gov.au/industry/reen. The site includes: a members directory; a discussion forum; information on opportunities to showcase Australian renewable; energy products and services; and Iinks to sites containing information that may be useful to renewable energy exporters. Other actions that are being undertaken as

  16. Regulation and Device Development: Tips for Optimizing Your Experience With the Food and Drug Administration.

    Science.gov (United States)

    Brooks, Steven S

    2017-06-01

    Physician-inventors are in a unique position to identify unserved patient needs, and innovate solutions to clinical problems. These solutions may also have associated commercial opportunities. The logistics of developing these medical products, however, can seem a daunting task. One of the primary barriers in the United States is the regulatory process of the Food and Drug Administration (FDA). In this article, we will explore the risk-based approach used by the FDA which forms a framework to consider the regulatory pathway and the process to gain regulatory clearance or approval for medical devices. Inherent device properties and the procedural risk of the devices will determine the rigor with which they are scrutinized by FDA, and the evidentiary requirements to legally market them. Data and evidentiary development will vary depending on risk and regulatory precedent and may or may not require clinical data This regulatory paradigm will determine into which risk-based device class they fit, and whether they are regulated under the 510(k) or premarket approval application pathways. The FDA, although gatekeeper of the US market and tasked with determining which products are safe and effective, can be a powerful ally for product development. They have significant scientific and medical expertise, and mechanisms to both provide guidance, and also to consider novel approaches to product development and evidence development. Early interaction for routine and novel products alike can result in expedited and efficient development. This collaborative approach can be best practice to most expeditiously develop the next generation of products, getting them into the hands of US doctors and into the treatment of US patients. Copyright © 2017. Published by Elsevier Inc.

  17. Exporting and Productivity

    DEFF Research Database (Denmark)

    Newman, Carol; Rand, John; Tarp, Finn

    2017-01-01

    different policy stance than typical in Africa. This is especially so in promoting export-oriented industry. If learning by exporting is a key driver of progress, then a fundamental reason for Africa's lack of transformation is likely to be the low policy priority given to export promotion in the past....... To enlarge the body of empirical evidence, we use an extensive 2005–2012 firm-level panel data set from Vietnam and separate out productivity effects of exporting due to self-selection. This allows us to conclude that firms actually learn by exporting. We also examine how this learning takes place. Our...... findings suggest that productivity gains are associated with moving to larger scale for foreign-owned firms with little evidence of subsequent learning on export markets. We find strong evidence to suggest that private domestic firms learn and accumulate knowledge from export markets with learning...

  18. 77 FR 14016 - General Services Administration Acquisition Regulation; Preparation, Submission, and Negotiation...

    Science.gov (United States)

    2012-03-08

    ..., Submission, and Negotiation of Subcontracting Plans; Correction AGENCY: General Services Administration (GSA..., Preparation, Submission, and Negotiation of Subcontracting Plans; Correction. Correction In the information...

  19. Relevance in print of law of administrative regulations according to paragraph 48 BImSchG in the licensing procedure

    International Nuclear Information System (INIS)

    Breuer, R.

    1978-01-01

    The author discusses in great detail the legal problem of administrative regulations according to paragraph 48 of the Bundes-Immissionsschutzgesetz, BImSchG (Federal Act for the prevention of immissions) and their relevance in point of law in licensing procedures. He very carefully and skilfully presents the different opinions stated in the precedents and by the body of doctrine and quite convincingly explains why he rejects the doctrine of allowing the administration some latitude in their judgement, and thus the doctrine of the defensible opinion with regard to the examination by the court of undefined legal terms. According to the auther's view, the administrative regulations should be regarded as anticipated expert opinions because of the way they are drawn up and because of the way the relevant committees setting up the rules are constituted, i.e. they can serve as a basis for judical decisions. In this connection the author points out that in any case it is left to the court's decisions whether a non-formal expert opinion is deemed to be sufficient, or whether the rules of procedure require a formal expert opinion. Furthermore, several ways of enhancing the binding effect of the administrative regulations pursuant to paragraph 48 of the BImSchG by means of legislatory measures are shown. (UN) [de

  20. Responsibilities of the exporting state derived from the application of the code of conduct on the safety and security of radioactive sources and the guidance on the import and export

    International Nuclear Information System (INIS)

    Vidal, Dora

    2008-01-01

    Full text: 'The exporting state in deciding whether to authorize an export of radioactive sources should satisfy itself, insofar as practicable: 1) That the recipient is authorized by the importing state to receive and possess the source in accordance with its laws and regulations; 2) That the importing state has the appropriate technical and administrative capability, resources and regulatory structure needed for the management of the source(s) in a manner consistent with the guidance in the code, and consider, based upon available information: i) Whether the recipient has been engaged in clandestine or illegal procurement of radioactive sources; ii) Whether an import or export authorization for radioactive sources has been denied to the recipient or importing state, or whether the recipient or importing state has made diverted for purposes inconsistent with the code any import or export of radioactive sources previously authorized; and iii) The risk of diversion or malicious acts involving radioactive sources'. It also should take, once it has decided to authorize the export, 'appropriate steps to ensure that the export is conducted in a manner consistent with existing relevant international standards relating to the transport of radioactive materials an the importing State is notified in advance of each shipment'. The Guidance has done a great effort in fixing the requirements that the importing State has to fulfill and it is the exporting State which has to verify, satisfy, and consider if these requirements are in place. It is remarkable the responsibility of the exporting state in analyzing the export from the point of view of the capabilities of the importing State to manage the sources with the purpose of use it has and even once it is not useful any more. This paper has the intention of bringing to reflect the responsibility of the exporting State in relation to those radioactive sources that are exported or are to be exported and have to fulfill with the

  1. 77 FR 28390 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 527...

    Science.gov (United States)

    2012-05-14

    .... Purpose The General Services Administration will be requesting the Office of Management and Budget to... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0007; Docket 2011-0016; Sequence 12] General... Qualifications and Financial Information AGENCY: Office of the Chief Finance Officer, GSA. ACTION: Notice of...

  2. 77 FR 5020 - General Services Administration Acquisition Regulation; Information Collection; GSA Form 527...

    Science.gov (United States)

    2012-02-01

    ... INFORMATION: A. Purpose The General Services Administration will be requesting the Office of Management and... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0007; Docket 2011-0001; Sequence 12] General... Qualifications and Financial Information AGENCY: Office of the Chief Finance Officer, GSA. ACTION: Notice of...

  3. Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal.

    Science.gov (United States)

    Kim, Ronald; Sepulveda-Orengo, Marian T; Healey, Kati L; Williams, Emily A; Reissner, Kathryn J

    2018-01-01

    Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of withdrawal, with longer access to cocaine and longer withdrawal periods leading to greater decreases in GLT-1 protein. However, the mechanism(s) by which cocaine downregulates GLT-1 protein remains unknown. We used qRT-PCR to examine gene expression of GLT-1 splice isoforms (GLT-1A, GLT-1B) in the NAc, prelimbic cortex (PL) and basolateral amygdala (BLA) of rats, following two widely used models of cocaine self-administration: short-access (ShA) self-administration, and the long-access (LgA) self-administration/incubation model. While downregulation of GLT-1 protein is observed following ShA cocaine self-administration and extinction, this model did not lead to a change in GLT-1A or GLT-1B gene expression in any brain region examined. Forced abstinence following ShA cocaine self-administration also was without effect. In contrast, LgA cocaine self-administration and prolonged abstinence significantly decreased GLT-1A gene expression in the NAc and BLA, and significantly decreased GLT-1B gene expression in the PL. No change was observed in NAc GLT-1A gene expression one day after LgA cocaine self-administration, indicating withdrawal-induced decreases in GLT-1A mRNA. In addition, LgA cocaine self-administration and withdrawal induced hypermethylation of the GLT-1 gene in the NAc. These results indicate that a decrease in NAc GLT-1 mRNA is only observed after extended access to cocaine combined with protracted abstinence, and that epigenetic mechanisms likely contribute to this effect. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Oil exports under GATT and the WTO

    International Nuclear Information System (INIS)

    Abdallah, H.

    2005-01-01

    This paper will try to focus on two aspects of oil production policy under the General Agreement on Tariffs and Trade (GATT) and the World Trade Organization. The first is how freely an oil producer can regulate the quantity of oil production and exports without violating GATT rules and the second is how an oil exporter could benefit from GATT rules to overstep barriers to market access imposed by oil-importing countries. (author)

  5. μ Opioid Receptor Expression after Morphine Administration Is Regulated by miR-212/132 Cluster.

    Directory of Open Access Journals (Sweden)

    Adrian Garcia-Concejo

    Full Text Available Since their discovery, miRNAs have emerged as a promising therapeutical approach in the treatment of several diseases, as demonstrated by miR-212 and its relation to addiction. Here we prove that the miR-212/132 cluster can be regulated by morphine, through the activation of mu opioid receptor (Oprm1. The molecular pathways triggered after morphine administration also induce changes in the levels of expression of oprm1. In addition, miR-212/132 cluster is actively repressing the expression of mu opioid receptor by targeting a sequence in the 3' UTR of its mRNA. These findings suggest that this cluster is closely related to opioid signaling, and function as a post-transcriptional regulator, modulating morphine response in a dose dependent manner. The regulation of miR-212/132 cluster expression is mediated by MAP kinase pathway, CaMKII-CaMKIV and PKA, through the phosphorylation of CREB. Moreover, the regulation of both oprm1 and of the cluster promoter is mediated by MeCP2, acting as a transcriptional repressor on methylated DNA after prolonged morphine administration. This mechanism explains the molecular signaling triggered by morphine as well as the regulation of the expression of the mu opioid receptor mediated by morphine and the implication of miR-212/132 in these processes.

  6. Exporter Price Premia?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte; Sørensen, Allan

    This paper provides new evidence on manufacturing firms' output prices: in Denmark, on average, exported varieties are sold at a lower price (i.e. a negative exporter price premium) relative to only domestically sold varieties. This finding stands in sharp contrast to previous studies, which have...... found positive exporter price premia. We also document that the exporter price premium varies substantially across products (both in terms of sign and magnitude). We show that in a standard heterogeneous firms model with heterogeneity in quality as well as production efficiency there is indeed no clear......-cut prediction on the sign of the exporter price premium. However, the model unambiguously predicts a negative exporter price premium in terms of quality-adjusted prices, i.e. prices per unit of quality. This prediction is broadly borne out in the Danish data: while the magnitude of the premium varies across...

  7. 77 FR 59613 - General Services Administration Acquisition Regulation (GSAR) Part 523; Submission for OMB Review...

    Science.gov (United States)

    2012-09-28

    ... items of hazardous material allows for appropriate handling of such items throughout GSA's supply chain... 3090- 0205 by any of the following methods: Regulations.gov : http://www.regulations.gov . Submit... customers. Non-Collection and/or a less frequently conducted collection of the information resulting from...

  8. 77 FR 36543 - General Services Administration Acquisition Regulation (GSAR) Part 523; Information Collection...

    Science.gov (United States)

    2012-06-19

    ... handling of such items throughout GSA's supply chain system. The information is used in GSA warehouses, stored in an NSN database and provided to GSA customers. Non-Collection and/or a less frequently... any of the following methods: Regulations.gov : http://www.regulations.gov . Submit comments via the...

  9. Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man.

    Science.gov (United States)

    Hallschmid, Manfred; Benedict, Christian; Born, Jan; Fehm, Horst-Lorenz; Kern, Werner

    2004-10-30

    Maintaining a stable body weight set-point is assumed to rely on a homeostatic central nervous system (CNS) regulation of body fat with the particular involvement of hypothalamic pathways. The peripheral adiposity signals insulin and leptin convey information on the amount of energy stored as body fat to the arcuate nucleus of the hypothalamus, where anabolic/orexigenic and catabolic/anorexigenic pathways interact to regulate food intake and energy expenditure. One of the most prominent orexigenic messengers is neuropeptide Y (NPY), whereas melanocortins, including alpha-melanocyte-stimulating hormone (alpha-MSH), are essential for inducing anorexigenic effects. The melanocortin receptor 4 (MC4-R) plays the most important role in mediating catabolic effects of alpha-MSH. In this review, we present a series of own studies on NPY, insulin and MSH/ACTH4-10, an MC4-R agonist. The studies were all based on the intranasal route of administration which enables a direct access of the peptides to hypothalamic functions. NPY acutely attenuated electrocortical signs of meal-related satiety. Prolonged intranasal administration of insulin as well as of MSH induced weight loss in healthy human subjects. However, overweight subjects did not lose body fat after MSH administration. The results corroborate in humans the significance of all three messengers for the central nervous regulation of adiposity and might contribute to the future development of medical strategies against body-weight-related disorders.

  10. [Vocational Health Schools (ETSUS) in Brazil: regulation of the integration of teaching-service-administrative sustainability of ETSUS].

    Science.gov (United States)

    Borges, Fabiano Tonaco; Garbin, Cléa Adas Saliba; Siqueira, Carlos Eduardo; Garbin, Artênio José Ísper; Rocha, Najara Barbosa da; Lolli, Luíz Fernando; Moimaz, Suzely Adas Saliba

    2012-04-01

    The scope of this study was to discuss the administrative sustainability of Brazil's Vocational Health Schools (ETSUS) based on the principle of teaching and service integration, which brings a new dimension to healthcare work as yet unregulated by Brazilian public administration. It was a qualitative study using case study methodology. The research involved a semi-structured questionnaire given to ETSUS managers addressing institutional, administrative, and work management aspects. The sample was composed of 6 ETSUS that belong to the Network of Vocational Health Schools (RET-SUS). The ETSUS showed centralized planning and management, and decentralized implementation of their core activities. The majority did not have administrative autonomy and relied heavily on funding from the federal government. According to ETSUS managers, the lack of regulation of teaching activities by civil servants weakens the management of ETSUS. The ETSUS have managerial problems related to teaching-service integration, which has to be regulated in order to guarantee the sustainability of these schools and avoid conflicts with Brazilian legislation.

  11. 76 FR 36986 - Export Controls for High Performance Computers: Wassenaar Arrangement Agreement Implementation...

    Science.gov (United States)

    2011-06-24

    ... and export control standards. Croatia is a member of the Australia Group, the Nuclear Suppliers Group..., Exports, Inventions and patents, Research science and technology. 15 CFR Part 740 Administrative practice...

  12. The effective dose and pattern of soybean extract administration to regulate body weight of laboratory rats

    Directory of Open Access Journals (Sweden)

    Meilinah Hidayat

    2016-07-01

    the intake of protein and suppress appetite for short-term. Detam 1 variety is a high-quality soybean according to the Minister of Agriculture of Indonesia. Soybean protein extract Detam 1 by Deak method contains high levels of β conglycinin. The purpose of this study was to determine the effective dose of protein extract Detam 1 soybean Deak Method (PEDSDM in reducing food intake, regulate body weight, and plasma CCK level for 14 and 28 days at various dosage and pattern of treatment on male Wistar rats. Methods: There were eleven groups of treatment (n = 3, administrated with extracts at 5 mg/1x/day, 10 mg/1x/day, 20 mg/1x/day, 2.5 mg/2x/day, 5 mg/2x/day, 10 mg/2x/day and 1.7mg/3x/day, 3.4mg/3x/day, 6.7 mg/3x/day, negative control group (distilled water and positive control group (Sibutramine. Food intake (g, weight loss (g and measurement of plasma Cholecystokinin levels by ELISA (ng /ml Results: The results showed that the highest percentage decrease in food intake is: group 3.4mg /3x/ day (p <0.05, inhibition weight gain for 14 days: group 10 mg /1x/ day, for 28 days: group 1.7 mg/3x/day (p <0.05, increased plasma Cholecystokinin levels: group 20 mg /1x/day (p <0.05. Conclusions: The effective dose and pattern administrating the rats for 14 days is extract of 10 mg once a day in the morning, for 28 days is 1.7 mg three times a day. (Health Science Journal of Indonesia 2016;7:17-26 Keywords: Soybean var Detam 1 -effective dose - body weight - Cholecystokinin 

  13. Export Control in the AREVA Group

    International Nuclear Information System (INIS)

    Zero, S.

    2013-01-01

    After the Second World War the nuclear technology was mostly considered inappropriate for the export. It remains strictly regulated today, but the development of the civil applications urged states to facilitate the peaceful uses while establishing a strict control in the domains of the internal security and the nuclear proliferation. AREVA decided to set up an Export Control program applied to all the products and in all the countries where the group operates. AREVA can export products or make transfer of technology considered as sensitive for the non-proliferation and the risks linked to the terrorism. This sensitiveness results from the nature of the products or from the country of destination and in certain cases both of them. AREVA has set up an Export Control program and an interactive e-learning training within the Group to make exports of sensitive products, raw materials and technologies more secure. The subject is rather complex, the regulations are constantly evolving, and becoming familiar with them is necessarily a gradual process, but it must be made in-depth, hence the idea of regular training sessions. The implementation of the Export Control in the AREVA Group declines in four fundamental stages: -) Policy and procedure; -) Appointment of Export Control Officers (ECO); -) Training; and -) Audit and Self Assessment. The training program is composed by the following elements: Ethics (Value Charter) of the Group, Non-proliferation, international regulations and more particularly those that are applicable in Europe (Germany and France) and in the United States. Particular attention is devoted to the Export Control practice in China, Japan and India. (A.C.)

  14. Demand Uncertainty: Exporting Delays and Exporting Failures

    DEFF Research Database (Denmark)

    Nguyen, Daniel Xuyen

    2012-01-01

    This paper presents a model of trade that explains why firms wait to export and why many exporters fail. Firms face uncertain demands that are only realized after the firm enters the destination. The model retools the timing of the resolution of uncertainty found in models with heterogeneity...... of firm productivity. This retooling addresses several shortcomings. First, the imperfect correlation of demands reconciles the sales variation observed in and across destinations. Second, since demands for the firm's output are correlated across destinations, a firm can use previously realized demands...... to forecast unknown demands in untested destinations. The option to forecast demands causes firms to delay exporting in order to gather more information about foreign demand. Third, since uncertainty is resolved after entry, many firms enter a destination and then exit after learning that they cannot profit...

  15. Local ordinances as an instrument of social exclusion: the regulation affecting the homeless is administrative law of the enemy

    Directory of Open Access Journals (Sweden)

    Eduardo Melero Alonso

    2017-03-01

    Full Text Available This paper discusses local ordinances, especially the so-called coexistence ordinances, to the extent they affect the daily activities of the homeless. There are three areas of regulation: the prohibition of begging; a ban on sleeping, washing and perform physiological needs in public spaces; and the prohibition of sorting through garbage. This regulation is subjected to a critical analysis, focusing on the fact that has an impact on the fundamental rights of the homeless. The basic parameters of control are the reserve of law and, above all, the principle of proportionality. The conclusion reached is that, in many cases, this regulation is not only illegal, it can also be included within the category Administrative Law of the enemy.

  16. Hydrological processes and permafrost regulate magnitude, source and chemical characteristics of dissolved organic carbon export in a peatland catchment of northeastern China

    Science.gov (United States)

    Guo, Yuedong; Song, Changchun; Tan, Wenwen; Wang, Xianwei; Lu, Yongzheng

    2018-02-01

    Permafrost thawing in peatlands has the potential to alter the catchment export of dissolved organic carbon (DOC), thus influencing the carbon balance and cycling in linked aquatic and ocean ecosystems. Peatlands along the southern margins of the Eurasian permafrost are relatively underexplored despite the considerable risks associated with permafrost degradation due to climate warming. This study examined dynamics of DOC export from a permafrost peatland catchment located in northeastern China during the 2012 to 2014 growing seasons. The estimated annual DOC loads varied greatly between 3211 and 19 022 kg yr-1, with a mean DOC yield of 4.7 g m-2 yr-1. Although the estimated DOC yield was in the lower range compared with other permafrost regions, it was still significant for the net carbon balance in the studied catchment. There were strong linkages between daily discharge and DOC concentrations in both wet and dry years, suggesting a transport-limited process of DOC delivery from the catchment. Discharge explained the majority of both seasonal and interannual variations of DOC concentrations, which made annual discharge a good indicator of total DOC load from the catchment. As indicated by three fluorescence indices, DOC source and chemical characteristics tracked the shift of flow paths during runoff processes closely. Interactions between the flow path and DOC chemical characteristics were greatly influenced by the seasonal thawing of the soil active layer. The deepening of the active layer due to climate warming likely increases the proportion of microbial-originated DOC in baseflow discharge.

  17. 76 FR 34886 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2011-06-15

    ... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... information technology (IT) supplies, services and systems with security requirements. DATES: Effective Date... effective date that include information technology (IT) supplies, services and systems with security...

  18. 77 FR 749 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2012-01-06

    ... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... orders that include information technology (IT) supplies, services and systems. DATES: Effective Date... 6, 2012 that include information technology (IT) supplies, services and systems with security...

  19. 75 FR 4565 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2010-01-28

    ... Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales Reporting AGENCY... Management and Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial [[Page 4566

  20. 76 FR 17138 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2011-03-28

    ... initiated research. Topics for discussion include the following: (1) What FDA Expects in a Pharmaceutical Clinical Trial; (2) Adverse Event Reporting--Science, Regulation, Error, and Safety; (3) Part 11 Compliance...

  1. 75 FR 51824 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Science.gov (United States)

    2010-08-23

    ... discussion include the following: (1) What FDA expects in a pharmaceutical clinical trial; (2) adverse event reporting--science, regulation, error, and safety; (3) Part 11 Compliance--Electronic signatures; (4...

  2. The Food and Drug Administration and Drug Legalization: A Brief Model of Regulation

    OpenAIRE

    Kalam, Murad

    2002-01-01

    This paper offers a brief model of FDA regulation of currently illegal narcotics in the United States. Given that nearly three out of four Americans believe that the drug war has failed, recent calls from prominent liberal and conservative thinkers to legalize drugs, and state “compassionate use†ballot initiatives, future drug legalization is at least conceivable in the United States. Yet, how would the FDA regulate NLD’s under its current st...

  3. Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.

    Science.gov (United States)

    Prince, Courtney D; Rau, Andrew R; Yorgason, Jordan T; España, Rodrigo A

    2015-01-21

    Extensive evidence suggests that the hypocretins/orexins influence cocaine reinforcement and dopamine signaling via actions at hypocretin receptor 1. By comparison, the involvement of hypocretin receptor 2 in reward and reinforcement processes has received relatively little attention. Thus, although there is some evidence that hypocretin receptor 2 regulates intake of some drugs of abuse, it is currently unclear to what extent hypocretin receptor 2 participates in the regulation of dopamine signaling or cocaine self-administration, particularly under high effort conditions. To address this, we examined the effects of hypocretin receptor 1, and/or hypocretin receptor 2 blockade on dopamine signaling and cocaine reinforcement. We used in vivo fast scan cyclic voltammetry to test the effects of hypocretin antagonists on dopamine signaling in the nucleus accumbens core and a progressive ratio schedule to examine the effects of these antagonists on cocaine self-administration. Results demonstrate that blockade of either hypocretin receptor 1 or both hypocretin receptor 1 and 2 significantly reduces the effects of cocaine on dopamine signaling and decreases the motivation to take cocaine. In contrast, blockade of hypocretin receptor 2 alone had no significant effects on dopamine signaling or self-administration. These findings suggest a differential involvement of the two hypocretin receptors, with hypocretin receptor 1 appearing to be more involved than hypocretin receptor 2 in the regulation of dopamine signaling and cocaine self-administration. When considered with the existing literature, these data support the hypothesis that hypocretins exert a permissive influence on dopamine signaling and motivated behavior via preferential actions on hypocretin receptor 1.

  4. 78 FR 57156 - General Services Administration Acquisition Regulation; Submission for OMB Review; Modifications...

    Science.gov (United States)

    2013-09-17

    ... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0302; Docket No. 2013-0001; Sequence 9... (GSAR) to add clause 552.243-81 Modifications (Federal Supply Schedule) and an Alternate I version of..., Modifications (Federal Supply Schedule). The alternate version of the clause implements and mandates electronic...

  5. 78 FR 60695 - Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the...

    Science.gov (United States)

    2013-10-02

    ... Consolidation of the Financial Management Service and the Bureau of the Public Debt Into the Bureau of the... Service''). The new bureau consolidated the bureaus formerly known as the Financial Management Service... Register on May 24, 2013. This consolidation requires reorganization of, and administrative changes to...

  6. 77 FR 59790 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Science.gov (United States)

    2012-10-01

    ... and Forms. This final rule is part of the General Services Administration Acquisition Manual (GSAM... the prescription for inclusion of the clause at 552.204-9, Personal Identity Verification Requirements... the ``National Industrial Security Program Operating Manual (NISPOM)'', and link to the web address...

  7. Learning by Exporting

    DEFF Research Database (Denmark)

    Cruz, Antonio; Newman, Carol; Rand, John

    2017-01-01

    In this article, we analyse the learning-by-exporting (LBE) hypothesis in the Mozambican context. Due to the presence of the ‘Born-Global’ phenomenon among exporters, we address the endogeneity introduced by self-selection, combining a generalised Blinder–Oaxaca approach with results from...

  8. Learning by Exporting

    DEFF Research Database (Denmark)

    Cruz, Antonio; Newman, Carol; Rand, John

    2017-01-01

    In this article, we analyse the learning-by-exporting (LBE) hypothesis in the Mozambican context. Due to the presence of the ‘Born-Global’ phenomenon among exporters, we address the endogeneity introduced by self-selection, combining a generalised Blinder–Oaxaca approach with results from traditi...

  9. Industrialisation, Exports and Employment.

    Science.gov (United States)

    Sabolo, Yves

    1980-01-01

    After reviewing trends in industrial production, exports, and employment in the Third World since 1960, the author discusses industrialization strategies based on the local processing of raw materials for export. Such processing has proved to be a major factor in job creation. (Author/SK)

  10. Nuclear export controls and nuclear safeguards

    International Nuclear Information System (INIS)

    Sevini, F.

    2013-01-01

    The export control of dual use goods has developed since the early seventies to counter nuclear proliferation. The paper provides an overview of dual-use export control issues also in relation with the Additional Protocol to the Comprehensive Safeguards Agreement, which requires States to provide declarations of the export of the controlled items listed in its Annex II, derived from the Nuclear Suppliers Group Trigger list. Recommendations for improvement are proposed. On the EU level, the paper summarises the framework set by the European Council Regulation 428/2009, requiring Member States to impose control on exports, brokering and transit of dual use goods. The Regulation includes the so-called 'EU dual-use control list' integrating the lists of dual-use items defined by the international regimes and requires also the control on intangible technology transfers as foreseen by U.N. Security Council Resolution 1540. ESARDA has recently launched a new sub-Working Group on export control, which raised large interest and may evolve to a full-fledged working group. Export control may provide an opportunity of technical collaboration between ESARDA and INMM. The paper is followed by the slides of the presentation. (author)

  11. Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration

    OpenAIRE

    Self, David W.; Choi, Kwang-Ho; Simmons, Diana; Walker, John R.; Smagula, Cynthia S.

    2004-01-01

    Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydro...

  12. Regulation of operant oral ethanol self-administration: a dose-response curve study in rats.

    Science.gov (United States)

    Carnicella, Sebastien; Yowell, Quinn V; Ron, Dorit

    2011-01-01

    Oral ethanol self-administration procedures in rats are useful preclinical tools for the evaluation of potential new pharmacotherapies as well as for the investigation into the etiology of alcohol abuse disorders and addiction. Determination of the effects of a potential treatment on a full ethanol dose-response curve should be essential to predict its clinical efficacy. Unfortunately, this approach has not been fully explored because of the aversive taste reaction to moderate to high doses of ethanol, which may interfere with consumption. In this study, we set out to determine whether a meaningful dose-response curve for oral ethanol self-administration can be obtained in rats. Long-Evans rats were trained to self-administer a 20% ethanol solution in an operant procedure following a history of excessive voluntary ethanol intake. After stabilization of ethanol self-administration, the concentration of the solution was varied from 2.5 to 60% (v/v), and operant and drinking behaviors, as well as blood ethanol concentration (BEC), were evaluated following the self-administration of a 20, 40, and 60% ethanol solution. Varying the concentration of ethanol from 2.5 to 60% after the development of excessive ethanol consumption led to a typical inverted U-shaped dose-response curve. Importantly, rats adapted their level and pattern of responding to changes in ethanol concentration to obtain a constant level of intake and BEC, suggesting that their operant behavior is mainly driven by the motivation to obtain a specific pharmacological effect of ethanol. This procedure can be a useful and straightforward tool for the evaluation of the effects of new potential pharmacotherapies for the treatment of alcohol abuse disorders. Copyright © 2010 by the Research Society on Alcoholism.

  13. Hydrological processes and permafrost regulate magnitude, source and chemical characteristics of dissolved organic carbon export in a peatland catchment of northeastern China

    Directory of Open Access Journals (Sweden)

    Y. Guo

    2018-02-01

    Full Text Available Permafrost thawing in peatlands has the potential to alter the catchment export of dissolved organic carbon (DOC, thus influencing the carbon balance and cycling in linked aquatic and ocean ecosystems. Peatlands along the southern margins of the Eurasian permafrost are relatively underexplored despite the considerable risks associated with permafrost degradation due to climate warming. This study examined dynamics of DOC export from a permafrost peatland catchment located in northeastern China during the 2012 to 2014 growing seasons. The estimated annual DOC loads varied greatly between 3211 and 19 022 kg yr−1, with a mean DOC yield of 4.7 g m−2 yr−1. Although the estimated DOC yield was in the lower range compared with other permafrost regions, it was still significant for the net carbon balance in the studied catchment. There were strong linkages between daily discharge and DOC concentrations in both wet and dry years, suggesting a transport-limited process of DOC delivery from the catchment. Discharge explained the majority of both seasonal and interannual variations of DOC concentrations, which made annual discharge a good indicator of total DOC load from the catchment. As indicated by three fluorescence indices, DOC source and chemical characteristics tracked the shift of flow paths during runoff processes closely. Interactions between the flow path and DOC chemical characteristics were greatly influenced by the seasonal thawing of the soil active layer. The deepening of the active layer due to climate warming likely increases the proportion of microbial-originated DOC in baseflow discharge.

  14. 75 FR 11842 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-03-12

    ..., licensing of Technology Rights and provision of Export Trade Facilitation Services, EFS International... already generally available to the trade or public. 2. EFS International will comply with requests made by... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 10-00002] Export Trade...

  15. 77 FR 73289 - Hazardous Substances and Articles; Administration and Enforcement Regulations: Revisions to...

    Science.gov (United States)

    2012-12-10

    ... of Animals, and the Physicians Committee for Responsible Medicine. 1. Non-animal Testing Alternatives... Hazardous Substances Act (FHSA). DATES: This rule is effective on January 9, 2013. FOR FURTHER INFORMATION... proposed amendments to the regulations that interpret, supplement, or provide alternatives to definitions...

  16. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... extension of a previously approved information collection requirement concerning cost accounting standards... include pertinent rules and regulations related to the Cost Accounting Standards along with necessary... impact estimates and descriptions in cost accounting practices and also to provide information on CAS...

  17. Legal and administrative problems in regulating public participation in licensing of nuclear installations

    International Nuclear Information System (INIS)

    Cornelis, J.C.

    1981-10-01

    This general analysis of the question of public acceptance of nuclear activities focuses on the problems met by all governmental authorities in implementing their nuclear programmes. The author highlights the need for more specific regulations aimed at guaranteeing fuller information of the public and ensuring closer participation by it. (NEA) [fr

  18. Knowledge Base, Exporting Activities, Innovation Openness and Innovation Performance

    OpenAIRE

    Spyros Arvanitis; Areti Gkypali; Kostas Tsekouras

    2014-01-01

    In this paper we demonstrate the complexity that regulates the innovation-exports nexus. In particular we argue that innovation and exports should be treated as latent variables in order to account for as many facets possible thus, accounting for multifaceted heterogeneity. In this context, the role of innovation openness ought to be highlighted within a unified framework, as it is considered an additional activity of firms’ knowledge creation strategy. In this line, innovation and exporting ...

  19. 19 CFR 351.514 - Export subsidies.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Export subsidies. 351.514 Section 351.514 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES... government, a benefit does not exist if the Secretary determines that the activities consist of general...

  20. The Hidden Cost of Regulation: The Administrative Cost of Reporting Serious Reportable Events.

    Science.gov (United States)

    Blanchfield, Bonnie B; Acharya, Bijay; Mort, Elizabeth

    2018-04-01

    More than half of the 50 states (27) and the District of Columbia require reporting of Serous Reportable Events (SREs). The goal is to hold providers accountable and improve patient safety, but there is little information about the administrative cost of this reporting requirement. This study was conducted to identify costs associated with investigating and reporting SREs. This qualitative study used case study methods that included interviewing staff and review of data and documents to investigate each SRE occurring at one academic medical center during fiscal year 2013. A framework of tasks and a model to categorize costs was created. Time was summarized and costs were estimated for each SRE. The administrative cost to process 44 SREs was estimated at $353,291, an average cost of $8,029 per SRE, ranging $6,653 for an environmental-related SRE to $21,276 for a device-related SRE. Care management SREs occurred most frequently, costing an average $7,201 per SRE. Surgical SREs, the most expensive on average, cost $9,123 per SRE. Investigation of events accounted for 64.5% of total cost; public reporting, 17.2%; internal reporting, 10.2%; finance and administration, 6.0%; and 2.1%, other. Even with 26 states mandating reporting, the 17.2% incremental cost of public reporting is substantial. Policy makers should consider the opportunity costs of these resources, averaging $8,029 per SRE, when mandating reporting. The benefits of public reporting should be collectively reviewed to ensure that the incremental costs in this resource-constrained environment continue to improve patient safety and that trade-offs are acknowledged. Copyright © 2017 The Joint Commission. Published by Elsevier Inc. All rights reserved.

  1. Iran, a gas exporter?

    International Nuclear Information System (INIS)

    Therme, C.

    2008-01-01

    The development of the gas sector has not allowed, up to now, Iran to become one of the main gas actors, whether it is on the regional or international market. This under-development of the gas sector finds expression, each winter, through the Iranian incapability to satisfy its domestic demand as well as its exportation commitments to Turkey or Armenia. In this study, the author tries to examine the origins of Iranian difficulties to increase its gas production and to abide by its commitments to export gas to other countries. The possibility of gas exportation from Iran to the European Union is also discussed

  2. Markups and Exporting Behavior

    DEFF Research Database (Denmark)

    De Loecker, Jan; Warzynski, Frederic Michel Patrick

    2012-01-01

    In this paper, we develop a method to estimate markups using plant-level production data. Our approach relies on cost minimizing producers and the existence of at least one variable input of production. The suggested empirical framework relies on the estimation of a production function and provides...... estimates of plant- level markups without specifying how firms compete in the product market. We rely on our method to explore the relationship be- tween markups and export behavior. We find that markups are estimated significantly higher when controlling for unobserved productivity; that exporters charge......, on average, higher markups and that markups increase upon export entry....

  3. Guide to software export

    CERN Document Server

    Philips, Roger A

    2014-01-01

    An ideal reference source for CEOs, marketing and sales managers, sales consultants, and students of international marketing, Guide to Software Export provides a step-by-step approach to initiating or expanding international software sales. It teaches you how to examine critically your candidate product for exportability; how to find distributors, agents, and resellers abroad; how to identify the best distribution structure for export; and much, much more!Not content with providing just the guidelines for setting up, expanding, and managing your international sales channels, Guide to Software

  4. Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.

    Science.gov (United States)

    Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho

    2015-04-01

    Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Coal exports still growing

    International Nuclear Information System (INIS)

    Blain, M.

    1998-01-01

    It is shown that the swings and roundabouts of the Asian economic shake out and Australian dollar devaluation are starting to work their way through the Australian export coal market. Perhaps somewhat surprisingly, at this stage the results are not proving to be as bad as were at first predicted by some market watchers. Export revenue and tonnages are up 12% for the year to July 98. Coal exports totaling $9.5 billion left Australia's shores in the 12 months confirming coal as Australia's single largest export revenue earner. Sales volumes in the present financial year are still increasing, the market being driven by steadily increasing Asian demand for steaming coal from places like Korea, Malaysia, Thailand and the Philippines

  6. Exploitative Learning by Exporting

    DEFF Research Database (Denmark)

    Golovko, Elena; Lopes Bento, Cindy; Sofka, Wolfgang

    Decisions on entering foreign markets are among the most challenging but also potentially rewarding strategy choices managers can make. In this study, we examine the effect of export entry on the firm investment decisions in two activities associated with learning about new technologies...... and learning about new markets ? R&D investments and marketing investments, in search of novel insights into the content and process underlying learning by exporting. We draw from organizational learning theory for predicting changes in both R&D and marketing investment patterns that accompany firm entry......, it is predominantly the marketing-related investment decisions associated with starting to export that lead to increases in firm productivity. We conclude that learning-by-exporting might be more properly characterized as ?learning about and exploiting new markets? rather than ?learning about new technologies...

  7. Quebec's electricity exports

    International Nuclear Information System (INIS)

    Averyt, W.F.

    1992-01-01

    In 1987 Hydro-Quebec exported over 16 TWh to New England and New York and it plans to export 3,500 MW of firm power, not interruptible, by the early 2000s. It estimates that the northeast US market has an additional potential of 9,000 MW. The export market has become more difficult than anticipated. The federal/state regulatory framework for electricity generation was changing - it encouraged small scale generation, cogeneration and conservation which decreased demand. Demand for power imports has also been influenced by pricing judgements and avoided costs. Environmental concerns and Native protest have become increasingly important factors affecting future export sales and hence the proposed James Bay developments. Regulatory changes affecting supply and pricing, concerns about continental impacts, about further development of electrical sources together with Native requirements will further complicate the Quebec-US electricity trade. (author)

  8. Nuclear export controls

    International Nuclear Information System (INIS)

    Thorne, C.E.

    1999-01-01

    One approach to describing the multilateral nuclear export controls is to do it according to time. This led to an interesting discovery, i.e. multilateral export controls have been defined by four distinct periods, the forst two of abut five years each, the second two about twice as long. These time periods have another interesting property. The two suppliers groups, which we will discuss in detail, have alternated in dominance over nearly thirty years. After describing the historical developments, the status of the present situation in multilateral nuclear export controls is examined, with the strengths and weaknesses. The future of multilateral nuclear export controls and possible ways that might be taken are considered

  9. Valie EXPORT Society. Overlok

    Index Scriptorium Estoniae

    2001-01-01

    Valie EXPORT Society asutasid 23. okt. 1999. a. Frankfurdis Kadi Estland, Killu Sukmit ja Mari Laanemets, kui olid külastanud austria naiskunstniku Valie Exporti näitust. Rühmituse aktsioonide kirjeldus

  10. Valie EXPORT Society Rooseumis

    Index Scriptorium Estoniae

    2002-01-01

    Malmös Rooseumi Kaasaegse Kunsti Keskuses näitus "Baltic Babel". Projekt koosneb Läänemeremaade linnades tegutsevate innovatiivsete gruppide aktsioonidest. Kuraator Charles Esche. Esinejatest (Eestist Valie Export Society: Kadi Estland, Killu Sukmit)

  11. The Regulated Third Sector: Administrative Practices Of Citizenship And Constitutional Efficiency Applied

    Directory of Open Access Journals (Sweden)

    Mateus Moura de Oliveira

    2016-12-01

    Full Text Available Beginning from an approach about the evolution of organizational models of the States, this work goals, initially, outline the evolution of these models in the Brazilian State, analyzing the development of the Third Sector as an exponent of the Managing State. Establish afterwards the development of the entities of civil society and the urge for its regulation due to dissemination of its many species. After short report of the most recent regulatory practices, the importance of the Sector concludes itself as apex of the active role of citizenship, whereas advocate the constitutional efficiency in the atuation of such entities.

  12. Canada's reactor exports

    International Nuclear Information System (INIS)

    Morrison, R.W.

    1981-01-01

    A brief sketch of the development of Canada's nuclear exports is presented and some of the factors which influence the ability to export reactors have been identified. The potential market for CANDUs is small and will develop slowly. The competition will be tough. There are few good prospects for immediate export orders in the next two or three years. Nonetheless there are reasonable opportunities for CANDU exports, especially in the mid-to-late 1980s. Such sales could be of great benefit to Canada and could do much to sustain the domestic nuclear industry. Apart from its excellent economic and technical performance, the main attraction of the CANDU seems to be the autonomy it confers on purchasing countries, the effectiveness with which the associated technology can be transferred, and the diversification it offers to countries which wish to reduce their dependence on the major industrial suppliers. Each sales opportunity is unique, and marketing strategy will have to be tailored to the customer's needs. Over the next decade, the factors susceptible to Canadian government action which are most likely to influence CANDU exports will be the political commitment of the government to those reactor exports, the performance established by the four 600 MWe CANDUs now nearing completion, the continuing successful operation of the nuclear program in Ontario, and the co-ordination of the different components of Canada's nuclear program (AECL, nuclear industry, utilities, and government) in putting forth a coherent marketing effort and following through with effective project management

  13. An exporter's checklist

    International Nuclear Information System (INIS)

    Englot, P.

    1995-01-01

    The benefits of exporting goods and services was discussed. The article listed a summary of issues which could be referred to to assist with the development of an effective plan to export. Some issues to consider were: (1) analysis of the export market, such as political and cultural issues, local legislation, competition, infrastructure, transportation and logistics, (2) internal issues, such as people, equipment, capital, time, understanding of the risks, relocation and identification of all costs, (3) sources of support such as banks, government and transporters, (4) development of a solid payment plan. It was concluded that exporting was not for the faint-hearted. It can be expensive, and time consuming, however, if approached in the right spirit it could be highly rewarding. As a rule of thumb, the probability of success was said to be directly related to the amount of effort put into the preparatory phase. Potential exporters were reminded of the very strong infrastructure that exists in Canada to promote and support export initiatives, including all levels of government, financial institutions, freight forwarders and innumerable consultant/specialists

  14. Indonesian coal export potential

    International Nuclear Information System (INIS)

    Millsteed, Ch.; Jolly, L.; Stuart, R.

    1993-01-01

    Indonesia's coal mining sector is expanding rapidly. Much of the increase in coal production since the mid-1980s has been exported. Indonesian coal mining companies have large expansion programs and continuing strong export growth is projected for the remainder of the 1990s. The low mining costs of indonesian coal, together with proximity to Asian markets, mean that Indonesia is well placed to compete strongly with other thermal coal exporters and win market share in the large and expanding thermal coal market in Asia. However, there is significant uncertainty about the likely future level of Indonesia's exportable surplus of coal. The government's planned expansion in coal fired power generation could constrain export growth, while the ability of producers to meet projected output levels is uncertain. The purpose in this article is to review coal supply and demand developments in Indonesia and, taking account of the key determining factors, to estimate the level of coal exports from Indonesia to the year 2000. This time frame has been chosen because all currently committed mine developments are expected to be on stream by 2000 and because it is difficult to project domestic demand for coal beyond that year. 29 refs., 8 tabs., 7 figs

  15. 19 CFR 351.519 - Remission or drawback of import charges upon export.

    Science.gov (United States)

    2010-04-01

    ... export. 351.519 Section 351.519 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... Remission or drawback of import charges upon export. (a) Benefit—(1) In general. The term “remission or... import charges. In the case of the remission or drawback of import charges upon export, a benefit exists...

  16. Export Taxes under Bertrand Duopoly

    OpenAIRE

    David Collie; Roger Clarke

    2006-01-01

    This article analyses export taxes in a Bertrand duopoly with product differentiation, where a home and a foreign firm both export to a third-country market. It is shown that the maximum-revenue export tax always exceeds the optimum-welfare export tax. In a Nash equilibrium in export taxes, the country with the low cost firm imposes the largest export tax. The results under Bertrand duopoly are compared with those under Cournot duopoly. It is shown that the absolute value of the export subsid...

  17. Predicted Impact of the Food and Drug Administration's Menu-Labeling Regulations on Restaurants in 4 New Jersey Cities.

    Science.gov (United States)

    Gruner, Jessie; DeWeese, Robin S; Lorts, Cori; Yedidia, Michael J; Ohri-Vachaspati, Punam

    2018-02-01

    To determine the proportion of restaurants that will be required to post calorie information under the Food and Drug Administration's menu-labeling regulations in 4 New Jersey cities. We classified geocoded 2014 data on 1753 restaurant outlets in accordance with the Food and Drug Administration's guidelines, which will require restaurants with 20 or more locations nationwide to post calorie information. We used multivariate logistic regression analyses to assess the association between menu-labeling requirements and census tract characteristics. Only 17.6% of restaurants will be affected by menu labeling; restaurants in higher-income tracts have higher odds than do restaurants in lower-income tracts (odds ratio [OR] = 1.55; P = .02). Restaurants in non-Hispanic Black (OR = 1.62; P = .02) and mixed race/ethnicity (OR = 1.44; P = .05) tracts have higher odds than do restaurants in non-Hispanic White tracts of being affected. Additional strategies are needed to help consumers make healthy choices at restaurants not affected by the menu-labeling law. These findings have implications for designing implementation strategies for the law and for evaluating its impact.

  18. Coal export facilitation

    International Nuclear Information System (INIS)

    Eeles, L.

    1998-01-01

    There is a wide range of trade barriers, particularly tariffs, in current and potential coal market. Commonwealth departments in Australia play a crucial role in supporting government industry policies. This article summarises some of more recent activities of the Department of Primary Industries and Energy (DPIE) in facilitating the export of Australian Coals. Coal export facilitation activities are designed to assist the Australian coal industry by directing Commonwealth Government resources towards issues which would be inappropriate or difficult for the industry to address itself

  19. Canada's nuclear export policy

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, R W; Wonder, E F [Carleton Univ., Ottawa, Ontario (Canada)

    1978-01-01

    The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology.

  20. Canada's nuclear export policy

    International Nuclear Information System (INIS)

    Morrison, R.W.; Wonder, E.F.

    1978-01-01

    The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology. (O.T.)

  1. 21 CFR 1313.24 - Waiver of 15-day advance notice for chemical exporters.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Waiver of 15-day advance notice for chemical... IMPORTATION AND EXPORTATION OF LIST I AND LIST II CHEMICALS Exportation of Listed Chemicals § 1313.24 Waiver of 15-day advance notice for chemical exporters. (a) Each regulated person shall provide to the...

  2. 76 FR 4089 - Proposed Information Collection; Comment Request; Automated Export System (AES) Program

    Science.gov (United States)

    2011-01-24

    ... export marketing strategies as well as provide a means for the assessment of the impact of exports on the..., Regulations, Outreach and Education Branch, U.S. Census Bureau, 4600 Silver Hill Road, Room 6K125, Washington... functions as the basis for the official U.S. export trade statistics. These statistics are used to determine...

  3. 15 CFR 1300.1 - Reporting of exports of technology to nonmarket economy countries.

    Science.gov (United States)

    2010-01-01

    ... nonmarket economy countries. 1300.1 Section 1300.1 Commerce and Foreign Trade Regulations Relating to... § 1300.1 Reporting of exports of technology to nonmarket economy countries. (a) For purposes of complying... the export of technology to a nonmarket economy country, exporters of such technology shall be deemed...

  4. ANALYTICAL APPROACHES TO THE STUDY OF EXPORT TRANSACTIONS

    Directory of Open Access Journals (Sweden)

    Ekaterina Viktorovna Medvedeva

    2015-12-01

    Full Text Available Analytical approaches to research of export operations depend on the conditions containing in separate external economic contracts with foreign buyers and also on a form of an exit of the Russian supplier of export goods to a foreign market. By means of analytical procedures it is possible to foresee and predict admissible situations which can have an adverse effect on a financial position of the economic subject. The economic entity, the engaged foreign economic activity, has to carry out surely not only the analysis of the current activity, but also the analysis of export operations. In article analytical approaches of carrying out the analysis of export operations are considered, on an example the analysis of export operations in dynamics is submitted, it is recommended to use the formulas allowing to estimate export in dynamics. For the comparative analysis export volume in the comparable prices is estimated. On the commodity groups including and quantitatively and qualitatively commensurable goods, the index of quantitative structure is calculated, the coefficient of delay of delivery of goods in comparison with other periods pays off. Carrying out the analysis allows to determine a tendency of change of export deliveries by export operations for the analyzed period for adoption of administrative decisions.Purpose Definition of the ways and receptions of the analysis applying when carrying out the analysis of export operations.Methodology in article economic-mathematical methods, and also statistical methods of the analysis were used.Results: the most informative parameters showing some aspects of carrying out the analysis of export operations are received.Practical implications it is expedient to apply the received results the economic subjects which are carrying out foreign economic activity, one of which elements are export operations.

  5. Correlations-Adjusted Export Market Diversification

    OpenAIRE

    Jung Joo La

    2011-01-01

    This paper introduces new export market diversification indices incorporated with correlations of business cycles among export partners to identify the actual effects of export market diversification on export instability. Three existing export market diversification indices reflect the dispersion level in terms of the number of export partners and their export shares, without a clear control for correlations among export earnings from export partners. In addition, they are underestimated or ...

  6. 15 CFR Supplement No. 2 to Part 766 - Guidance on Charging and Penalty Determinations in Settlement of Administrative Enforcement Cases...

    Science.gov (United States)

    2010-01-01

    ... suspended on the basis of adverse economic consequences only if it is found that future violations of the... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS... as the “antiboycott provisions”). It also describes how BIS makes penalty determinations in the...

  7. Tools for Export Promotion in the Context of Globalization

    Directory of Open Access Journals (Sweden)

    Pugachevska Kateryna S.

    2017-12-01

    Full Text Available A comparative analysis of the rate of growth in exports of goods and GDP is carried out, and goods exports to GDP ratio in the context of the developed countries, developing countries, and countries with the transition economy is calculated. This allows to make a conclusion about a decrease in importance of exports as a key engine of the world economic growth during the past years. The legal basis of the WTO’s activities in terms of state support for exports is described. The main reasons for the emergence of a conflict of interests between countries with different levels of economic development concerning the use of individual protectionist barriers are revealed. Potential long-term consequences of the growth of export orientation under conditions of openness of national economies are identified. The measures and tools of the country’s export promotion in foreign markets are studied. It is grounded that under conditions of destabilization of global trade regulators, effective export promotion is a mechanism for increasing the competitiveness of the national economy of Ukraine. Prospects for further research in this area are the determination of instruments to stimulate exports, which have the greatest impact on the export orientation of certain economic activities.

  8. Composition of Exports and Export Performance of Eurozone Countries

    NARCIS (Netherlands)

    Wierts, P.J.; Kerkhoff, H.; de Haan, J.

    2014-01-01

    This article investigates to what extent the composition of exports is related to the export performance of eurozone countries using a data set on exports from the oldest eurozone countries to their top 20 trade partners for the period 1988-2009. The results suggest that a higher share of high

  9. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques

    Science.gov (United States)

    Siciliano, Cody A.; Calipari, Erin S.; Yorgason, Jordan T.; Lovinger, David M.; Mateo, Yolanda; Jimenez, Vanessa A.; Helms, Christa M.; Grant, Kathleen A.; Jones, Sara R.

    2016-01-01

    Rationale Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use, and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergic deficiencies are unknown. Objective Here we examined the specific dopaminergic adaptations that produce hypodopaminergia and contribute to alcohol use disorders using direct, sub-second measurements of dopamine signaling in nonhuman primates following chronic ethanol self-administration. Methods Female rhesus macaques completed one year of daily (22 hr/day) ethanol self-administration. Subsequently, fast-scan cyclic voltammetry was used in nucleus accumbens core brain slices to determine alterations in dopamine terminal function, including release and uptake kinetics, and sensitivity to quinpirole (D2/D3 dopamine receptor agonist) and U50,488 (kappa-opioid receptor agonist) induced inhibition of dopamine release. Results Ethanol drinking greatly increased uptake rates, which were positively correlated with lifetime ethanol intake. Furthermore, the sensitivity of dopamine D2/D3 autoreceptors and kappa-opioid receptors, which both act as negative regulators of presynaptic dopamine release, were moderately and robustly enhanced in ethanol drinkers. Conclusions Greater uptake rates and sensitivity to D2-type autoreceptor and kappa-opioid receptor agonists could converge to drive a hypodopaminergic state, characterized by reduced basal dopamine and an inability to mount appropriate dopaminergic responses to salient stimuli. Together, we outline the specific alterations to dopamine signaling that may drive ethanol-induced hypofunction of the dopamine system, and suggest that the dopamine and dynorphin/kappa-opioid receptor systems may be efficacious pharmcotherapeutic targets in the treatment of alcohol use disorders. PMID:26892380

  10. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques.

    Science.gov (United States)

    Siciliano, Cody A; Calipari, Erin S; Yorgason, Jordan T; Lovinger, David M; Mateo, Yolanda; Jimenez, Vanessa A; Helms, Christa M; Grant, Kathleen A; Jones, Sara R

    2016-04-01

    Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergic deficiencies are not fully understood. Here we examined the specific dopaminergic adaptations that produce hypodopaminergia and contribute to alcohol use disorders using direct, sub-second measurements of dopamine signaling in nonhuman primates following chronic ethanol self-administration. Female rhesus macaques completed 1 year of daily (22 h/day) ethanol self-administration. Subsequently, fast-scan cyclic voltammetry was used in nucleus accumbens core brain slices to determine alterations in dopamine terminal function, including release and uptake kinetics, and sensitivity to quinpirole (D2/D3 dopamine receptor agonist) and U50,488 (kappa opioid receptor agonist) induced inhibition of dopamine release. Ethanol drinking greatly increased uptake rates, which were positively correlated with lifetime ethanol intake. Furthermore, the sensitivity of dopamine D2/D3 autoreceptors and kappa opioid receptors, which both act as negative regulators of presynaptic dopamine release, was moderately and robustly enhanced in ethanol drinkers. Greater uptake rates and sensitivity to D2-type autoreceptor and kappa opioid receptor agonists could converge to drive a hypodopaminergic state, characterized by reduced basal dopamine and an inability to mount appropriate dopaminergic responses to salient stimuli. Together, we outline the specific alterations to dopamine signaling that may drive ethanol-induced hypofunction of the dopamine system and suggest that the dopamine and dynorphin/kappa opioid receptor systems may be efficacious pharmacotherapeutic targets in the treatment of alcohol use disorders.

  11. The Regulation of Nuclear Trade: Non-Proliferation-Supply-safety

    International Nuclear Information System (INIS)

    1988-01-01

    Volume II of the study on the regulation of nuclear trade deals with the national legislation of OECD countries with significant nuclear programmes and regulations in that field and, in essence, covers two aspects. The first concerns political and administrative controls over imports and exports of sensitive products, namely fissile materials and large nuclear equipment as well as technology transfers. In most cases, this description of the provisions applicable is completed with the list of nuclear items whose export is restricted. The second aspect concerns the licensing system governing trade in as well as the import and export of nuclear material to protect users and the public against the hazards created by its radioactive properties. This volume also contains information on regulations concerning physical protection, industrial property and transport, as well as on multilateral and bilateral agreements involving nuclear trade. (NEA) [fr

  12. 76 FR 10082 - Office of International Trade; State Trade and Export Promotion (STEP) Grant Program

    Science.gov (United States)

    2011-02-23

    ... translation fees, The design of international marketing products or campaigns, An export trade show exhibit... SMALL BUSINESS ADMINISTRATION Office of International Trade; State Trade and Export Promotion... Administrator of the Office of International Trade (OIT) that does not duplicate the services of other SBA...

  13. 76 FR 19174 - State Trade and Export Promotion (STEP) Pilot Grant Program

    Science.gov (United States)

    2011-04-06

    ... Grant Program is to increase the number of small businesses that are exporting, and increase the value... SMALL BUSINESS ADMINISTRATION State Trade and Export Promotion (STEP) Pilot Grant Program AGENCY: Office of International Trade; U.S. Small Business Administration (SBA) ACTION: SBA Program Announcement...

  14. Protein Export According to Schedule: Architecture, Assembly, and Regulation of Type III Secretion Systems from Plant- and Animal-Pathogenic Bacteria

    Science.gov (United States)

    2012-01-01

    Summary: Flagellar and translocation-associated type III secretion (T3S) systems are present in most Gram-negative plant- and animal-pathogenic bacteria and are often essential for bacterial motility or pathogenicity. The architectures of the complex membrane-spanning secretion apparatuses of both systems are similar, but they are associated with different extracellular appendages, including the flagellar hook and filament or the needle/pilus structures of translocation-associated T3S systems. The needle/pilus is connected to a bacterial translocon that is inserted into the host plasma membrane and mediates the transkingdom transport of bacterial effector proteins into eukaryotic cells. During the last 3 to 5 years, significant progress has been made in the characterization of membrane-associated core components and extracellular structures of T3S systems. Furthermore, transcriptional and posttranscriptional regulators that control T3S gene expression and substrate specificity have been described. Given the architecture of the T3S system, it is assumed that extracellular components of the secretion apparatus are secreted prior to effector proteins, suggesting that there is a hierarchy in T3S. The aim of this review is to summarize our current knowledge of T3S system components and associated control proteins from both plant- and animal-pathogenic bacteria. PMID:22688814

  15. Gene transcripts selectively down-regulated in the shell of the nucleus accumbens long after heroin self-administration are up-regulated in the core independent of response contingency.

    Science.gov (United States)

    Jacobs, Edwin H; de Vries, Taco J; Smit, August B; Schoffelmeer, Anton N M

    2004-01-01

    Long-term drug-induced alterations in neurotransmission within the nucleus accumbens (NAc) shell and core may underlie relapse to drug-seeking behavior and drug-taking upon re-exposure to drugs and drug-associated stimuli (cues) during abstinence. Using an open screening strategy, we recently identified 25 gene transcripts, encoding for proteins involved in neuronal functioning and structure that are down-regulated in rat NAc shell after contingent (active), but not after non-contingent (passive), heroin administration. Studying the expression of the same transcripts in the NAc core by means of quantitative PCR, we now demonstrate that most of these transcripts are up-regulated in that NAc subregion long (3 weeks) after heroin self-administration in rats. A similar up-regulation in gene expression was also apparent in the NAc core of animals with a history of non-contingent heroin administration (yoked controls). These data indicate that heroin self-administration differentially regulates genes in the NAc core as compared with the shell. Moreover, whereas cognitive processes involved in active drug self-administration (e.g., instrumental learning) seems to direct gene expression in the NAc shell, neuroplasticity in the NAc core may be due to the pharmacological effects of heroin (including Pavlovian conditioning), as expressed in rats upon contingent as well as non-contingent administration of heroin.

  16. 75 FR 65449 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-10-25

    ... of Competition and Economic Analysis, International Trade Administration, by telephone at (202) 482... CFR part 325 (2010). The Office of Competition and Economic Analysis (``OCEA'') is issuing this notice... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 94-4A007] Export Trade...

  17. Exporting Humanist Architecture

    DEFF Research Database (Denmark)

    Nielsen, Tom

    2016-01-01

    The article is a chapter in the catalogue for the Danish exhibition at the 2016 Architecture Biennale in Venice. The catalogue is conceived at an independent book exploring the theme Art of Many - The Right to Space. The chapter is an essay in this anthology tracing and discussing the different...... values and ethical stands involved in the export of Danish Architecture. Abstract: Danish architecture has, in a sense, been driven by an unwritten contract between the architects and the democratic state and its institutions. This contract may be viewed as an ethos – an architectural tradition...... with inherent aesthetic and moral values. Today, however, Danish architecture is also an export commodity. That raises questions, which should be debated as openly as possible. What does it mean for architecture and architects to practice in cultures and under political systems that do not use architecture...

  18. Nuclear exporters cartel

    International Nuclear Information System (INIS)

    Mandelbaum, M.

    1977-01-01

    Events that have transpired in the past few years that have caused renewed concern about the spread of nuclear weapons are reviewed. Many proposals have been made recently for keeping the bomb from spreading. The author feels that the most novel and intriguing of them is the one advanced by Senator Abraham Ribicoff and Steven J. Baker; in their proposal, the world market for nuclear reactors would be divided into precisely defined shares among the industrial nations that now manufacture them for export; each exporter would be guaranteed a certain number of sales annually; and each would pledge not to sell uranium enrichment or plutonium reprocessing technology, as Germany did to Brazil. This might not halt proliferation, but it would give the world a few more years to find a solution

  19. Export development financing

    International Nuclear Information System (INIS)

    Balint, J.

    1995-01-01

    The main activities of the Export Development Corporation (EDC) were described, as well as some of the changes currently being implemented. EDC is Canada's official export credit agency, providing risk management services such as insurance, loans, guarantees, equity and leasing. EDC's project finance initiative started in 1991, and focused mainly on the up-front process. It has established itself as a recognized leader in project financing. It has over 15 years experience in a variety of sectors and countries. Energy projects financed to date include hydro projects in India, Argentina and Pakistan, and thermal projects in Thailand, China, Indonesia and Egypt. Lending criteria used to select projects were outlined, along with the risks endemic to project financing

  20. Gas Exports in Turkmenistan

    International Nuclear Information System (INIS)

    Vasanczki, Luca Zs.

    2011-01-01

    The Caspian region has been at the center of attention since Europe began seeking alternative routes to natural-gas resources. Turkmenistan has the potential to become an important gas exporter to Europe. As a landlocked country, Turkmenistan until recently has relied on post-Soviet pipeline infrastructures. The Central Asian republic has been at the mercy of Moscow's energy policy, which overlaps its foreign policy. At the same time, the revenue from gas exports is an essential part of the Turkmen national budget. This prompted Ashgabat to look for energy partners bypassing Russian territories. It started to convey natural gas first to Iran and then to China. This gave Turkmenistan strong leverage vis-a-vis Moscow. Ashgabat has not decided to export every gas molecule eastward, but, in jeopardizing its relations with Moscow, it expects more than empty pledges from Europe. On the other hand, a simple question emerges: Does Europe really need alternative sources? The answer is in the hands of Gazprom and Russian policy-makers

  1. Exports of petroleum products, 1987

    International Nuclear Information System (INIS)

    1988-04-01

    A summary is presented of exports of motor gasoline, middle distillate, aviation turbine fuel, heavy fuel oil, and partially processed oil from Canada for the 1987 calendar year. A discussion of petroleum product imports is included in order to put exports in the context of the overall trade. Exports of the above petroleum products averaged 22,200 m 3 /d in 1987, up 15% from 1986 levels. Exports of middle distillates and aviation fuel had the largest gains in 1987. Export prices for light petroleum products stayed relatively close to USA spot prices. The heavy fuel oil price was below the New York spot price in the beginning of 1987 but remained close for the rest of the year. Canada's petroleum products exports were made to 5 countries while imports came from at least 13 countries. The USA remained Canada's largest trading partner in petroleum products. Exports to Japan and the Far East rose ca 60% over 1986. Product outturns for export were 9% of total Canadian refinery throughput. Exports of aviation turbine fuel from Ontario began in April 1987. The top single exporter in Canada was Irving Oil Ltd. with 2,485,000 m 3 . Irving was also the top exporter in 1986. 11 figs., 4 tabs

  2. Energy Building Regulations: The Effect of the Federal Performance Standards on Building Code Administration and the Conservation of Energy in New Buildings.

    Science.gov (United States)

    Kopper, William D.

    1980-01-01

    Explores the changes in the administration and enforcement of building regulations that will be engendered by the proposed federal energy building standards. Also evaluates the effectiveness of those standards in meeting congressional intent. Available from U.C. Davis Law Review, School of Law, Martin Luther King Jr. Hall, University of…

  3. Analysis and prediction of leucine-rich nuclear export signals

    DEFF Research Database (Denmark)

    La Cour, T.; Kiemer, Lars; Mølgaard, Anne

    2004-01-01

    We present a thorough analysis of nuclear export signals and a prediction server, which we have made publicly available. The machine learning prediction method is a significant improvement over the generally used consensus patterns. Nuclear export signals (NESs) are extremely important regulators...... this analysis is that the most important properties of NESs are accessibility and flexibility allowing relevant proteins to interact with the signal. Furthermore, we show that not only the known hydrophobic residues are important in defining a nuclear export signals. We employ both neural networks and hidden...

  4. Combating global warming. Possible rules, regulations and administrative arrangements for a global market in CO2 emission entitlements

    International Nuclear Information System (INIS)

    1994-12-01

    When in 1991 the UNCTAD secretariat launched its research into the idea of controlling carbon dioxide emissions through a system of 'tradeable permits', there was little support for this approach. Some felt that the idea was premature and should not detract from efforts to introduce more conventional measures, such as environmental taxes and new regulations. However, in a few short years, the idea of using tradeable market-based instruments to combat global warming has gained widespread acceptance. The UNCTAD secretariat's 1992 study on a global system of tradeable carbon emission entitlements (UNCTAD/RDP/DFP/1), was widely regarded as a major breakthrough in this area. This study argued that tradeable permits were both an efficient means of controlling man-made carbon dioxide emissions at minimum cost, and an effective mechanism for transferring resources to developing countries and countries in transition, to help them to contribute to the international effort to abate emissions of greenhouse gases. The study contained a detailed assessment of key technical elements of a tradeable CO 2 entitlements system, including permit allocation techniques, resource transfers, equity/distributional implications, institutional and administrative requirements. The present publication explores the institutional requirements for both policy-making and the organization of a global market in CO 2 emission allowances. It shows that one can start with a simple pilot scheme based on the joint implementation of commitments, which constitutes the cornerstone of the Framework Convention, and evolve gradually to a more complete system on the basis of 'learning by doing'. Since the use of markets can dramatically lower the cost of controlling greenhouse gas emissions, it is clearly in the self-interest of major emitters to act as 'market leaders' willing to pioneer

  5. Examining the role of export competitive advantages on export performance

    OpenAIRE

    Yeganeh Alimohammadi; Reza Aghamousa; Fataneh Alizadeh Meshkani

    2014-01-01

    This paper investigates the role of export competitive advantage on export performance in food industry. The proposed study designs a questionnaire in Likert scale and distributes it among 280 randomly selected experts in food industry and Cronbach alpha has been calculated as 0.827. The study has applied factor analysis to find important factors influencing export performance. Kaiser-Meyer-Olkin Measure of Sampling Adequacy and Bartlett's Test of Sphericity have been performed to validate th...

  6. The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA.

    Science.gov (United States)

    Booth, David S; Cheng, Yifan; Frankel, Alan D

    2014-12-08

    The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions. The RRE assembles a Rev oligomer that displays nuclear export sequences (NESs) for recognition by the Crm1-Ran(GTP) nuclear receptor complex. Here we provide the first view of an assembled HIV-host nuclear export complex using single-particle electron microscopy. Unexpectedly, Crm1 forms a dimer with an extensive interface that enhances association with Rev-RRE and poises NES binding sites to interact with a Rev oligomer. The interface between Crm1 monomers explains differences between Crm1 orthologs that alter nuclear export and determine cellular tropism for viral replication. The arrangement of the export complex identifies a novel binding surface to possibly target an HIV inhibitor and may point to a broader role for Crm1 dimerization in regulating host gene expression.

  7. Exporting to Russia?

    DEFF Research Database (Denmark)

    Thomsen, Lotte

    2016-01-01

    the aspects of territoriality and institutional context, and suggests their integration into one concept, or rather a process of contextualizing territories. In doing so, the article argues for a methodology that not only examines current events, but also captures change as particularly important in what we......This article draws on extensive fieldwork conducted in Central Asia to explore food exports to Russia. It takes its theoretical starting point in global value chain theory and pinpoints chain entry barriers relating to financing, transportation and standards. The article also proposes rethinking...

  8. Soviet energy export prospects

    Energy Technology Data Exchange (ETDEWEB)

    Scanlan, Tony

    1991-05-01

    The Soviet Union produces 20% of world energy but since 1988 this is in decline. Awakening consumerism and a sea-change in the structure of foreign trade and internal investment are placing this key industry into unprecedented uncertainty. The difference between success and failure goes beyond the 1988 peak of six million barrels daily of exports in oil equivalent. The article quantifies the key areas of energy uncertainty as equal in volume to total OPEC output and sees the long-term changes of success more than ever dependent on coordinated planning and investment as well as on market reality. (Author).

  9. Danish Exports and Danish Bilateral Aid

    DEFF Research Database (Denmark)

    Hansen, Henrik; Rand, John

    higher in the 1980s compared to in particular the most recent decade. This may be related to factors such as untying of aid in the same period. The econometric analysis has two important limitations. First of all, the model can only give information about marginal changes in aid. As a decision to give...... and trade policies. The main result of the study is that Danish bilateral aid has a positive and statistically significant impact on Danish exports to the recipient countries. Bilateral development assistance may affect exports through several channels. Three of the main channels are direct aid tying......; increasing recipient income where higher income leads to higher imports, and decreased trade costs, say due to improved information about cultural and administrative customs and practices. Thus, as for preferential trade arrangements, bilateral aid has two potential economic effects; trade creation working...

  10. 31 CFR 538.406 - Exportation of services; performance of service contracts; legal services.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Exportation of services; performance of service contracts; legal services. 538.406 Section 538.406 Money and Finance: Treasury Regulations... SUDANESE SANCTIONS REGULATIONS Interpretations § 538.406 Exportation of services; performance of service...

  11. 31 CFR 537.202 - Prohibited exportation or reexportation of financial services to Burma.

    Science.gov (United States)

    2010-07-01

    ... reexportation of financial services to Burma. 537.202 Section 537.202 Money and Finance: Treasury Regulations... permit granted prior to July 29, 2003, the exportation or reexportation of financial services to Burma... BURMESE SANCTIONS REGULATIONS Prohibitions § 537.202 Prohibited exportation or reexportation of financial...

  12. 31 CFR 537.305 - Exportation or reexportation of financial services to Burma.

    Science.gov (United States)

    2010-07-01

    ... financial services to Burma. 537.305 Section 537.305 Money and Finance: Treasury Regulations Relating to... SANCTIONS REGULATIONS General Definitions § 537.305 Exportation or reexportation of financial services to Burma. The term exportation or reexportation of financial services to Burma means: (a) The transfer of...

  13. Export Variety and Country Productivity

    OpenAIRE

    Feenstra, Robert; Looi Kee, Hiau

    2004-01-01

    The authors study the link between export product variety and country productivity based on data from 34 industrial and developing countries, from 1982 to 1997. They measure export product variety by the share of U.S. imports on the set of goods exported by each sampled country relative to the world. It is a theoretically sound index which is consistent with within-country GDP maximization...

  14. Import-Export Business Plan

    OpenAIRE

    Asad, Muhammad

    2014-01-01

    Import export businesses, also known as international trading, are one of the hottest commercial trends of this decade. Since the owner of an import export enterprise, can work as a distributor by focusing on exporting and importing goods and services that cannot be obtained on national soil. With a rapidly growing population of about 150 million, Pakistan is a major country, recognized by the international community, and is one of the most important actors in the Islamic world. Based on its ...

  15. Political implications of US nuclear-export-policy development

    International Nuclear Information System (INIS)

    Johnson-Freese, J.S.

    1981-01-01

    There has been a great deal of international debate regarding how effective strict export controls on nuclear-energy supplies are toward a non-proliferation goal. With the Carter Administration, the debate was heightened by a new, more-vigorous US nuclear-export policy, much of which was codified by the Nuclear Non-Proliferation Act of 1978 (NNPA). Because of the US position in both the international non-proliferation regime and nuclear export market, the NNPA has had far-reaching consequences. The thesis of this paper is that a nuclear-export policy that fails to consider its short-term ramifications, as the NNPA has been accused of, will be self-defeating. If the US wants a viable worldwide nuclear non-proliferation policy, it must first direct its efforts toward building a domestic non-proliferation consensus, and then worldwide, rather than first setting a highly controversial policy and expecting other nations to fall into line. This work provides a comprehensive case study of US nuclear-export policy between the years 1976 to 1980 in support of the thesis. Further, the behavior and impact of the interest groups which seem to shape US nuclear-export policies is examined, and recommendations made regarding the role of groups in nuclear policy-making and implementation. Finally, recommendations are made regarding non-proliferation policy for the future, as it relates to nuclear exports

  16. Information Interaction with IAEA on Nuclear Import and Export

    International Nuclear Information System (INIS)

    Osokina, A.; Snytnikov, A.

    2015-01-01

    This paper considers organizational aspects of nuclear import and export interaction between the Russian Federation and the Agency. Requirements of nuclear import and export in Russia, information submission procedure and forms are determined in RF Government Regulation No 973 from December 15th 2000. Particularly, according to these requirements Russian licenced organizations implementing nuclear import and export submit reports about appointed transfers to State Corporation 'Rosatom'. Regulations of State Corporation 'Rosatom' entrusted gathering and processing of reporting information and interaction with IAEA to FSUE 'SCC of Rosatom'. Regulations of reporting information interaction were developed by SCC and approved by State Corporation 'Rosatom'. Russian organizations send notifications to SCC using regulation electron or paper forms. Regulations determine information security measures in reporting process. Automated nuclear import and export accounting system developed by SCC provides data entering, keeping and processing, enables to choose and submit requested information in different formats. This system is integrated with State Nuclear Material Control and Accounting System. Also submitted information is regularly compared with customs declarations data to improve reliability and consistency of information. Generalized nuclear import and export data is using by Departments of State Corporation 'Rosatom' and transmitting to Federal Environmental, Industrial and Nuclear Supervision Service of Russia in agreed forms. Summary information about international nuclear transfers is sending to IAEA according to INFCIRC/207. Reporting information is coordinating. Messaging with IAEA is realized by email using enciphering program. (author)

  17. Protein export through the bacterial flagellar type III export pathway.

    Science.gov (United States)

    Minamino, Tohru

    2014-08-01

    For construction of the bacterial flagellum, which is responsible for bacterial motility, the flagellar type III export apparatus utilizes both ATP and proton motive force across the cytoplasmic membrane and exports flagellar proteins from the cytoplasm to the distal end of the nascent structure. The export apparatus consists of a membrane-embedded export gate made of FlhA, FlhB, FliO, FliP, FliQ, and FliR and a water-soluble ATPase ring complex consisting of FliH, FliI, and FliJ. FlgN, FliS, and FliT act as substrate-specific chaperones that do not only protect their cognate substrates from degradation and aggregation in the cytoplasm but also efficiently transfer the substrates to the export apparatus. The ATPase ring complex facilitates the initial entry of the substrates into the narrow pore of the export gate. The export gate by itself is a proton-protein antiporter that uses the two components of proton motive force, the electric potential difference and the proton concentration difference, for different steps of the export process. A specific interaction of FlhA with FliJ located in the center of the ATPase ring complex allows the export gate to efficiently use proton motive force to drive protein export. The ATPase ring complex couples ATP binding and hydrolysis to its assembly-disassembly cycle for rapid and efficient protein export cycle. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. © 2013 Elsevier B.V. All rights reserved.

  18. Russian nuclear industry exports

    International Nuclear Information System (INIS)

    Gorbatchev, A.

    2016-01-01

    Rosatom is the world leader for the export of nuclear technologies. 34 reactors of Russian technology are being built or planned worldwide. Most reactors proposed by Rosatom are third generation VVER-1200 units with an electric power output of 1200 MWe. Although the nuclear island is always built by Rosatom, the remain of the plant can be subcontracted to other enterprises and European companies are sought because they would bring a european quality touch to Russian works. One of the main assets of Rosatom is to propose an integrated offer from supplying nuclear fuel to managing nuclear waste via the turnkey building of nuclear power plants. Another important asset is the financial assistance of the Russian state through state credit or the support from Russian national banks that appears to be a decisive advantage in the international competition to win markets. We have to temper the Russian export perspectives by noting that most projects are set in countries that are prone to instabilities and that the economic crisis affecting Russia has a negative impact on its financial means. (A.C.)

  19. Exports of petroleum products, 1988

    International Nuclear Information System (INIS)

    1989-04-01

    A summary is presented of exports of motor gasoline, middle distillate, aviation turbine fuel, heavy fuel oil, and partially processed oil from Canada for the 1988 calendar year. A discussion of petroleum product imports is included in order to put exports in the context of the overall trade. Exports of the above petroleum products averaged 32,000 m 3 /d in 1988, up 44% from 1987 levels. Each product except aviation fuel registered increases in export volumes, which reached the highest total volume of the decade. The main reason for the large increase was the first full year of production from the export-directed refinery at Come By Chance, Newfoundland. Export prices for light petroleum products stayed relatively close to USA spot prices. The heavy fuel oil price was mostly above the USA east coast spot price during 1988. Attractive prices on the USA east coast resulted in a few cargoes of middle distillate and motor gasoline shipped from British Columbia. Petroleum products imports came from 12 countries; Quebec had the largest volume of imports in 1988. The USA remained Canada's largest trading partner in petroleum products. Western exporters view the Far East as an ongoing important market. The top single exporter in Canada was Newfoundland Processing, with 32% of the total export volume. 12 figs., 3 tabs

  20. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  1. Export incentives, exchange rate policy and export growth in Turkey

    NARCIS (Netherlands)

    van Wijnbergen, S.J.G.; Arslan, I.

    1993-01-01

    The driving forces behind the Turkish export miracle, and in fact its very existence, have remained a matter of debate We show there was a boom. As to contributing factors, import growth in the Middle East in excess of import growth elsewhere made a negative contribution. On exports to non-oil

  2. Nuclear technology and the export control laws

    International Nuclear Information System (INIS)

    Munroe, J.L.; Pankratz, M.C.; Hogsett, V.H.; Lundy, A.S.

    1988-01-01

    Three basic US laws regulate the export of commodities, services, and technical data. People working in nuclear fields need to know of these laws and their impact on professional endeavors. Export of technical data means the communication of any information by oral, written, or any other means to foreign nationals within or outside the US. The medium for the communication may be a model, blueprint, sketch, or any other device that can convey information. If the data relates to items on one of the control lists, a license must be sought from the appropriated federal agency. The Militarily Critical Technologies List (MCTL), though not itself a control list, plays a major role in determining what technical data will require a validated license. The US Department of Energy (DOE), through Technical Working Gorup (TWG) 11, is responsible for the Nuclear Technology chapter of the MCTL. TWG 11 also prepares the Nuclear Technology Reference Book (NTRB), a classified guide to sensitive nuclear technology

  3. NPT, export controls and nuclear trade

    International Nuclear Information System (INIS)

    Pande, Savita

    1997-01-01

    Nuclear trade has by and large remained unhampered vis-a-vis both the NPT as well as export control regulations. The NPT rules are regarded as insufficient, the guidelines appear to contravene the spirit of cooperation in trade and development between suppliers and recipients and there is no agreement among leading suppliers themselves on what constitutes the proper conduct of trade. Export control regimes are more or less too informal to be able to be implemented. The supplier states have to invariably depend on national legislations which again vary from country to country. The only common formal basis on which action can be taken is, therefore, the NPT, its loopholes notwithstanding. The idea of transparency, and supplier-recipient dialogue continues to be a myth and will continue to be so long as these regimes remain discriminatory, so long as some nations are more powerful than others by virtue of retaining nuclear weapons and superiority in nuclear technology and trade

  4. A Study on the Export Control System at KAERI

    International Nuclear Information System (INIS)

    Kim, I. C.; Lee, B. D.; Kim, H. J.; Kim, H. S.; Jung, J. A.

    2015-01-01

    The current non-proliferation regime requires strengthening the export control from Korea to foreign countries. This means that the ministries related to export control deeply emphasize the prohibition of the illegal proliferation in the domestic society as well as international society. The principle of export control for non-proliferation of WMD is to control the transfer of the strategic items/technology to the countries which intend to develop the WMD in accordance with the multilateral agreements of the Nuclear Supply Group (NSG), Wassenaar Agreement (WA), Austrian Group (AG) and Missile Technology Control Regime (MTCR). Among them, export controls at KAERI are deeply related to the guidelines of the NSG, an international nuclear export control regime. Since the new concept of an export system was launched in Jan. 2014, KAERI needs to consider new approaches to meet the requirement of the revised domestic law and regulation. To cope with this environmental change, this paper suggests new approaches to effectively conduct the export control at KAERI

  5. The south's timer export potential

    Science.gov (United States)

    James E. Granskog

    1986-01-01

    Exports of southern wood products have bccil dcclirling since 1980, following a dramatic rise during the 1970s. The value of these exports rose from near the $50 million level in the early 1970s to almost $500 million in 1980, but has dropped by more than a third since then. Now, however, changing monetary conditions appear to be turning the trend upward again....

  6. Insurability of export credit risks

    NARCIS (Netherlands)

    Alsem, K.J.; Antufjew, J.; Huizingh, K.R.E.; Koning, Ruud H.; Sterken, E.; Woltil, M.

    2003-01-01

    Firms exporting their goods and services abroad face risks that are different from the risks faced by firms who do not engage in international trade. It is common practice to allow the receiving party to pay in instalments. The exporting firm faces credit risk, but as in most countries, Dutch firms

  7. Exports of crude oil, 1988

    International Nuclear Information System (INIS)

    1989-06-01

    Effective June 1, 1985, licensing and charging of oil exports ended. The Board now issues export orders specifying neither volumes nor prices and covering an exportation period of up to 1 year for light crude oil and up to 2 years for heavy crude oil, available on request to both Canadian and foreign companies. The Board has assumed a monitoring role, and export prices and volumes are reported monthly by exporters. This annual report provides a review of the volumes and prices associated with the supply and disposition of Canadian crude oil during 1988. Highlights are given with detailed information on prices, both internationally, in Canada, and the Chicago posted price by light or heavy crude, and on volumes including capacity and disposition in both domestic and export markets. A short description of the import market is included. Comparisons are made with the previous year. Export volumes of light crude oil in 1988 increased by 13% to average 50,200 m 3 /d. Export volumes of heavy crude also increased by ca 13% to 62,600 m 3 /d. 15 figs., 2 tabs

  8. Mexico: Imports or exports?

    International Nuclear Information System (INIS)

    Estrada, J.

    2002-01-01

    This presentation provides an overview of Mexico's energy sector. Proven oil reserves place Mexico in ninth position in the world and fourth largest in natural gas reserves. Energy is one of the most important economic activities of the country, representing 3 per cent of Gross Domestic Product (GDP). Oil exports represent 8.4 per cent of total exports. Approximately 40 per cent of total public investment is earmarked for energy projects. The author discusses energy resources and energy sector limitations. The energy sector plan for the period 2001-2006 is discussed. Its goals are to ensure energy supply, to develop the energy sector, to stimulate participation of Mexican enterprises, to promote renewable energy sources, and to strengthen international energy cooperation. The regulatory framework is being adapted to increase private investment. Some graphs are presented, displaying the primary energy production and primary energy consumption. Energy sector reforms are reviewed, as are electricity and natural gas reforms. The energy sector demand for 2000-2010 and investment requirements are reviewed, as well as fuel consumption for power generation. The author discusses the National Pipeline System (SNG) and the bottlenecks caused by pressure efficiency in the northeast, flow restriction on several pipeline segments, variability of the Petroleos Mexicanos (PEMEX) own use, and pressure drop on central regions. The entire prospect for natural gas in the country is reviewed, along with the Strategic Gas Program (PEG) consisting of 20 projects, including 4 non-associated natural gas, 9 exploration and 7 optimization. A section dealing with multiple service contracts is included in the presentation. The authors conclude by stating that the priority is a national energy policy to address Mexico's energy security requirements, to increase natural gas production while promoting the diversification of imports, and a regulatory framework to be updated in light of current

  9. Inhibitory effects of ginseng total saponin on up-regulation of cAMP pathway induced by repeated administration of morphine.

    Science.gov (United States)

    Seo, Jeong-Ju; Lee, Jae-Woong; Lee, Wan-Kyu; Hong, Jin-Tae; Lee, Chong-Kil; Lee, Myung-Koo; Oh, Ki-Wan

    2008-02-01

    We have reported that ginseng total saponin (GTS) inhibited the development of physical and psychological dependence on morphine. However, the possible molecular mechanisms of GTS are unclear. Therefore, this study was undertaken to understand the possible molecular mechanism of GTS on the inhibitory effects of morphine-induced dependence. It has been reported that the up-regulated cAMP pathway in the LC of the mouse brain after repeated administration of morphine contributes to the feature of withdrawals. GTS inhibited up-regulation of cAMP pathway in the LC after repeated administration of morphine in this experiment. GTS inhibited cAMP levels and protein expression of protein kinase A (PKA). In addition, GTS inhibited the increase of cAMP response element binding protein (CREB) phosphorylation. Therefore, we conclude that the inhibitory effects of GTS on morphine-induced dependence might be mediated by the inhibition of cAMP pathway.

  10. NEW APPROACHES TO EXPORT COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Alina Petronela NEGREA

    2015-04-01

    Full Text Available The economic literature and the political discourse typically look at international competitiveness mainly by the means of export market shares. However, globalisation, production fragmentation and the growing importance of global value chains (GVCs increasingly challenge traditional approaches of export competitiveness and call for a more accurate and disaggregated level of analysis. Due to the growing fragmentation of production, a country exports now include a significant amount of imports of intermediate goods which are part of the export value. In this case, a simple analysis of the evolution of exports can distort the international competitive position of a country. The article suggests a new approach based on the value-added content of international trade measured by means of global value chain analysis.

  11. Second Thoughts on Exporter Productivity

    DEFF Research Database (Denmark)

    Sørensen, Allan; Schröder, Philipp J.H.

    Empirical literature has established a positive link between firm productivity and export status, yet notable exceptions exist. The present paper shows that the underlying theory (Melitz, 2003) is in fact able to accommodate the rule as well as the exception. The fulcrum of the argument is the te......Empirical literature has established a positive link between firm productivity and export status, yet notable exceptions exist. The present paper shows that the underlying theory (Melitz, 2003) is in fact able to accommodate the rule as well as the exception. The fulcrum of the argument...... is the tension between empirical work measuring productivity based on average cost information, and theoretical work representing productivity by marginal cost. In a heterogeneous firms trade model, we compute productivity based on average cost and find that around the export-indifferent firm, exporters...... will be less productive than non-exporters. Furthermore, we show that this effect may feed through at the industry level....

  12. EVALUATING AND DEVELOPING LOGISTICS SYSTEM FOR EXPORTING SMALL AND MEDIUM ENTERPRISES (CASE STUDY IN YOGYAKARTA PROVINCE AND ADJACENT AREAS, INDONESIA

    Directory of Open Access Journals (Sweden)

    Rizkie Syahputera

    2013-05-01

    The recommendations are established by developing 5th party logistics, constructing clear and market responsive regulations, and improving the facilities of transport infrastructure. Keywords: SME, logistics, Indonesia, export.

  13. Global Landslide Catalog Export

    Data.gov (United States)

    National Aeronautics and Space Administration — The Global Landslide Catalog (GLC) was developed with the goal of identifying rainfall-triggered landslide events around the world, regardless of size, impacts or...

  14. 75 FR 41693 - Export Inspection and Weighing Waiver for High Quality Specialty Grains Transported in Containers

    Science.gov (United States)

    2010-07-19

    ... Specialty Grains Transported in Containers AGENCY: Grain Inspection, Packers and Stockyards Administration... rule to potentially make permanent the current waiver for high quality grain exported in containers... exported in containers that was established by a final rule on December 13, 2005 (70 FR 73556). This...

  15. 19 CFR 351.515 - Internal transport and freight charges for export shipments.

    Science.gov (United States)

    2010-04-01

    ... shipments. 351.515 Section 351.515 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... Internal transport and freight charges for export shipments. (a) Benefit—(1) In general. In the case of internal transport and freight charges on export shipments, a benefit exists to the extent that the charges...

  16. 19 CFR 351.517 - Exemption or remission upon export of indirect taxes.

    Science.gov (United States)

    2010-04-01

    ... taxes. 351.517 Section 351.517 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... Exemption or remission upon export of indirect taxes. (a) Benefit. In the case of the exemption or remission upon export of indirect taxes, a benefit exists to the extent that the Secretary determines that the...

  17. 75 FR 37756 - Request for Public Comment To Inform Development of National Export Initiative Plan

    Science.gov (United States)

    2010-06-30

    ... with financing, and in general by pursuing a government-wide approach to export advocacy abroad, among other steps. General information concerning the NEI and government programs that help U.S. businesses... To Inform Development of National Export Initiative Plan AGENCY: International Trade Administration...

  18. Examining the role of export competitive advantages on export performance

    Directory of Open Access Journals (Sweden)

    Yeganeh Alimohammadi

    2014-04-01

    Full Text Available This paper investigates the role of export competitive advantage on export performance in food industry. The proposed study designs a questionnaire in Likert scale and distributes it among 280 randomly selected experts in food industry and Cronbach alpha has been calculated as 0.827. The study has applied factor analysis to find important factors influencing export performance. Kaiser-Meyer-Olkin Measure of Sampling Adequacy and Bartlett's Test of Sphericity have been performed to validate the results and they both validated the questionnaire. The results of the survey have determined six effective groups including product development, e-commerce, marketing planning, organizational performance, competitiveness and supply chain management.

  19. Exporting environmental products: A small business's perspective

    International Nuclear Information System (INIS)

    Marsh, K.

    1992-01-01

    If the last year and a half are any indication it would appear that the early 1990's will be to international trade what the early 1980's were to entrepreneurship. Embraced by the popular and business press and encouraged by the administration, exporting has become one of the most talked about topics in business today. As manufacturers, consultants and service providers we are continually told that to survive in the world marketplace we must think globally and compete aggressively. There can be no doubt that export markets, always an interesting sector of business, have become both more important and exciting in recent years. On January 1, 1993 the unified common market of the European Community will officially open for business. Although most of the significant changes in that market have already taken place or been agreed upon, this historic event - creating the single largest market among industrial nations - will undoubtedly have an effect on how we as exporters do business in Europe. The Free Trade Agreement with Canada has been in effect for over two years now and there have been and will continue to be many benefits for us. In developing and newly capitalist countries we can point to Czechoslovakia and Hungary as the first of several potentially lucrative markets. Mexico, in the spotlight due to the new Free Trade initiative, will be a strong new export market in our own backyard. And finally the so called mini-dragons of Southeast Asia cannot be ignored. Whether or not they choose to create a formal trading bloc, their ever increasing foreign reserves should be looked at with hungry, but cautious eyes. In this paper the author identifies a large and ever increasing world of customers beyond our national borders and identifies how those companies and individuals in the environmental products market can benefit greatly

  20. Intraventricular administration of Tenebrio molitor larvae extract regulates food intake and body weight in mice with high-fat diet-induced obesity.

    Science.gov (United States)

    Seo, Minchul; Kim, Jongwan; Moon, Seong-Su; Hwang, Jae-Sam; Kim, Mi-Ae

    2017-08-01

    We recently reported the in vitro and in vivo antiobesity effects of Tenebrio molitor larvae, a traditional food in many countries, but it remains unknown how the larvae affect appetite regulation in mice with diet-induced obesity. We hypothesized that the extract of T molitor larvae mediates appetite by regulating neuropeptide expression. We investigated T molitor larvae extract's (TME's) effects on anorexigenesis and endoplasmic reticulum (ER) stress-induced orexigenic neuropeptide expression in the hypothalami of obese mice. Intracerebroventricular TME administration suppressed feeding by down-regulating the expression of the orexigenic neuropeptides neuropeptide Y and agouti-related protein. T molitor larvae extract significantly reduced the expression of ER stress response genes. These results suggest that TME and its bioactive components are potential therapeutics for obesity and ER stress-driven disease states. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. The export potential of traditional varieties of rice from Bangladesh

    OpenAIRE

    Stringfellow, Rachel; Swetman, Tony

    1996-01-01

    This research is funded by the Overseas Development Administration's Crops Post Harvest Programme. The objective of the research is to bring together information on prevailing quality/price relationships for traditional varieties of rice in Bangladesh and for competing products on the world market in order to make a judgement about Bangladesh's ability to enter the export trade for speciality rices.

  2. 77 FR 37385 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-06-21

    ... fund direct market development or market competitiveness improvement projects to benefit the Sector... antitrust actions and from private, treble damage antitrust actions for the export conduct specified in the... administration of COLOM-PEQ and fund market access maintenance, market promotion and market competitiveness...

  3. 75 FR 75963 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-12-07

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 92-9A001] Export Trade... Industries Association of America (``AIA'') (Application 92-9A001). SUMMARY: The U.S. Department of Commerce...: Accenture is now located in Chicago, IL, with controlling entity Accenture plc, Dublin, Ireland; AAR...

  4. Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1

    OpenAIRE

    Prince, Courtney D.; Rau, Andrew R.; Yorgason, Jordan T.; Espa?a, Rodrigo A.

    2014-01-01

    Extensive evidence suggests that the hypocretins/orexins influence cocaine reinforcement and dopamine signaling via actions at hypocretin receptor 1. By comparison, the involvement of hypocretin receptor 2 in reward and reinforcement processes has received relatively little attention. Thus, although there is some evidence that hypocretin receptor 2 regulates intake of some drugs of abuse, it is currently unclear to what extent hypocretin receptor 2 participates in the regulation of dopamine s...

  5. Canadian solar export market study. Export policy recommendations

    Energy Technology Data Exchange (ETDEWEB)

    1983-11-01

    This report outlines policies and recommendations on the export of Canadian solar equipment and technology, with a view toward stimulating the domestic solar industry. The current picture is of an industry which is relatively small, operates in a competitive domestic market with low profit margins, and needs assistance in order to break into the world market. A number of recommendations are therefore made on the main thrust of industry and government solar export development activities. An export development program is described which includes a strategy of concentrating on a limited number of product lines, namely: low-temperature solar heating systems for recreational applications, integrated residential water heating systems, prepackaged commercial water heating systems, and industrial pre-heat systems. It is also recommended that this strategy be directed only at a limited number of target countries where the market justifies such activity. Market research, international cooperation agreements, promotional services, and proper export organization are also needed.

  6. Export financing in France

    International Nuclear Information System (INIS)

    Richard-Mounet, J.

    1985-01-01

    This review of market conditions, credit types and the OECD ''Consensus'' focuses on the regulation of credit and the prefinancing requirements. The two types of credit granted to the client - buyer credit or supplier credit - are compared

  7. The implications of uranium export

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    It is argued that Australia should not enter the business of uranium mining enrichment and export because of the hazards of nuclear power and because there are practical alternatives to the development of nuclear power. (R.L.)

  8. Australia's uranium export potential

    International Nuclear Information System (INIS)

    Mosher, D.V.

    1981-01-01

    During the period 1954-71 in Australia approximately 9000 MT of U 3 O 8 was produced from five separate localities. Of this, 7000 MT was exported to the United Kingdom and United States and the balance stockpiled by the Australian Atomic Energy Commission (AAEC). Australia's uranium ore reserves occur in eight deposits in three states and the Northern Territory. However, 83% of Australia's reserves are contained in four deposits in lower Proterozoic rocks in the East Alligator River region of the Northern Territory. The AAEC has calculated Australia's recoverable uranium reserves by eliminating estimated losses during the mining and milling of the ores. AAEC has estimated reasonably assured resources of 289,000 MT of uranium at a recovery cost of less than US$80 per kilogram uranium. The companies have collectively announced a larger ore reserve than the Australian Atomic Energy Commission. This difference is a result of the companies adopting different ore reserve categories. On August 25, 1977, the federal government announced that Australia would develop its uranium resources subject to stringent environmental controls, recognition of Aboriginal Land Rights, and international safeguards. Australian uranium production should gradually increase from 1981 onward, growing to 10,000 to 15,000 MT by 1985-86. Further increases in capacity may emerge during the second half of the 1980s when expansion plans are implemented. Exploration for uranium has not been intensive due to delays in developing the existing deposits. It is likely that present reserves can be substantially upgraded if more exploration is carried out. 6 figures, 3 tables

  9. BRAZILIAN EXPORTS OF MANUFACTURED WOOD

    Directory of Open Access Journals (Sweden)

    Rafael de Azevedo Calderon

    2010-08-01

    Full Text Available The present work deals with the Brazilian exports of sawnwood of non-coniferous, veneer sheets and plywood, from 1961 to 2002. The data regarding the three studied products, sawnwood of non-coniferous, veneer sheets and plywood, were joined through the method of Fisher so that an econometric evaluation of the market of the three products could be carried out. Supply and demand models of the Brazilian exports were specified. The results were satisfactory and they match with the literature. The supply of exports presented a positive answer in relation to the exporter's remuneration, to the production, to the use of the installed capacity (cycles of domestic economical activity and to the tendency, and negative in relation to the internal demand. The demand for the Brazilian exports was influenced positively by the world income, participation index and tendency, and negatively for the relative price. The low elasticity-price of the found demand can have implications in the conservation of the Brazilian forest resources because the exporters can increase the prices, reduce the amounts and still increase the incomes.

  10. Exports of petroleum products, 1990

    International Nuclear Information System (INIS)

    1991-04-01

    A summary is presented of exports of motor gasoline, middle distillate, aviation turbine fuel, heavy fuel oil, and partially processed oil from Canada for the 1990 calendar year. Exports of the above petroleum products averaged 34,000 m 3 /d in 1990, up 12% from 1989 levels. The increase reflects increased output from the Come By Chance refinery in Newfoundland. Motor gasoline exports increased 35% to 10,500 m 3 /d, reflecting refinery upgrading in eastern Canada. Export prices were generally in line with spot product prices in the USA. Spot prices rose sharply following the Kuwait crisis in August 1990 but fell again in November. The spot price for jet fuel rose more dramatically in that period than for other products, reflecting increased military demand. In winter 1989/90 and during the Kuwait conflict, the export price of heating oil tended to track the USA spot price. Petroleum products imports in 1990 were 18,500 m 3 /d, compared to 21,900 m 3 /d in 1988. Imports were lower partially as a result of higher crude runs in Quebec and a Quebec refinery expansion. Imports of heavy fuel oil in eastern Canada continued to be strong in comparison to the mid-1980s. The top single exporter in 1990, as in 1989, was Newfoundland Processing, with a volume of 4,506,400 m 3 . 13 figs., 5 tabs

  11. Exports of petroleum products, 1989

    International Nuclear Information System (INIS)

    1990-04-01

    A summary is presented of exports of motor gasoline, middle distillate, aviation turbine fuel, heavy fuel oil, and partially processed oil from Canada for the 1989 calendar year. A discussion of petroleum product imports is included in order to put exports in the context of the overall trade. Exports of the above petroleum products averaged 30,400 m 3 /d in 1989, down 5% from 1988 levels. Motor gasoline shipments showed the largest decrease, down 1,500 m 3 to 7,700 m 3 /d. Export prices for light petroleum products stayed relatively close to USA spot prices except in June and July 1989, when attractive prices were obtained for shipments from the prairie provinces. The heavy fuel oil export price was similar to the USA east coast spot price in 1989, except in December. Canada's petroleum products imports in 1989 were 21,600 m 3 /d, compared to 18,400 m 3 /d in 1988. Imports of heavy fuel oil in eastern Canada rose 36% in 1989 because of industries switching from electricity and the high demand for thermal power generation. The USA remained Canada's largest trading partner in petroleum products. The top single exporter in 1989, as in 1988, was Newfoundland Processing, with a volume of 3,484,500 m 3 . 24 figs., 4 tabs

  12. 22 CFR 124.3 - Exports of technical data in furtherance of an agreement.

    Science.gov (United States)

    2010-04-01

    ... approved in writing by the Directorate of Defense Trade Controls (DDTC) and the technical data does not... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of technical data in furtherance of an... REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.3 Exports of technical data in...

  13. 7 CFR 319.8-16 - Importation into United States of cotton and covers exported therefrom.

    Science.gov (United States)

    2010-01-01

    ... covers exported therefrom. (a) Cotton and covers grown, produced, or handled in the United States and... 7 Agriculture 5 2010-01-01 2010-01-01 false Importation into United States of cotton and covers exported therefrom. 319.8-16 Section 319.8-16 Agriculture Regulations of the Department of Agriculture...

  14. Define rules for the exporter and importer of minerals or ores containing nuclear elements

    International Nuclear Information System (INIS)

    1969-01-01

    The present resolution establishes regulations for the exporter of minerals or ores containing associated nuclear elements, and for the importer of chemical compounds of technical purity grade, containing a quantity of fissile of fertile materials equal to the existent in the exported material

  15. 22 CFR 126.1 - Prohibited exports and sales to certain countries.

    Science.gov (United States)

    2010-04-01

    ... policy applies to Belarus, Cuba, Eritrea, Iran, North Korea, Syria, and Venezuela. This policy also... REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.1 Prohibited exports and sales to certain countries. (a) General. It is the policy of the United States to deny licenses and other approvals for exports and...

  16. The anatomy of China's export growth

    OpenAIRE

    Amiti, Mary; Freund, Caroline

    2008-01-01

    Decomposing China's real export growth, of over 500 percent since 1992, reveals a number of interesting findings. First, China's export structure changed dramatically, with growing export shares in electronics and machinery and a decline in agriculture and apparel. Second, despite the shift into these more sophisticated products, the skill content of China's manufacturing exports remained ...

  17. E-business and small Ghanaian exporters

    DEFF Research Database (Denmark)

    Hinson, Robert; Sørensen, Olav Jull

    2006-01-01

    The arfticle aims to investigate the relationship between export intensity and e-business adoption in Ghana. No clear relationship is found among exporters of non-traditional items.......The arfticle aims to investigate the relationship between export intensity and e-business adoption in Ghana. No clear relationship is found among exporters of non-traditional items....

  18. 27 CFR 28.30 - Export status.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export status. 28.30... Export status. (a) Distilled spirits and wines manufactured, produced, bottled in bottles packed in... such purposes are considered to be exported. Export status is not acquired until application on Form...

  19. Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.

    Science.gov (United States)

    Olive, Michael Foster; Newton, Philip M

    2010-09-01

    Studies using targeted gene deletion in mice have revealed distinct roles for individual isozymes of the protein kinase C (PKC) family of enzymes in regulating sensitivity to various drugs of abuse. These changes in drug sensitivity are associated with altered patterns of drug self-administration. The purpose of this review is to summarize behavioral studies conducted on mice carrying targeted deletions of genes encoding specific PKC isozymes (namely the beta, gamma, delta, and epsilon isozymes), and to critically evaluate the possibility of using pharmacological inhibitors of specific PKC isozymes as modulators of the sensitivity to various drugs of abuse, as well as potential aids in the treatment of substance use disorders.

  20. 15 CFR 730.5 - Coverage of more than exports.

    Science.gov (United States)

    2010-01-01

    ..., shipments from a U.S. foreign trade zone, and the electronic transmission of non-public data that will be... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Coverage of more than exports. 730.5 Section 730.5 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued...

  1. 31 CFR 500.533 - Exportations, reexportations, and incidental transactions.

    Science.gov (United States)

    2010-07-01

    ... CONTROL REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 500.533 Exportations..., software, or technology (including technical data) from the United States or reexportation of U.S.-origin goods, software, or technology from a foreign country to any person in a designated foreign country or...

  2. Evaluation of the Transfer of International Traffic in Arms Regulations-Controlled Missile Defense Technology to the National Aeronautics and Space Administration (NASA)

    Science.gov (United States)

    2015-07-13

    120.19) occurs. He said even where an export does occur, in many cases transfers between U.S. Government agencies are exempted under ITAR 126.4 from...services is not an export under the ITAR and, to the extent it is, that any exemptions to license requirements are properly applied. Importantly, the...National Defense Authorization Act for Fiscal Year 2015,” we conducted an evaluation of the transfer of specific International Traffic in Arms

  3. Roles of Dietary Cobalt and Administration of Mixed Rumen Bacteria in Regulating Hematological Parameters of Pre-weaning Twin Lambs

    Directory of Open Access Journals (Sweden)

    T. Adelina

    2013-08-01

    Full Text Available Cobalt (Co is required by rumen microorganism for vitamin B12 synthesis. Vitamin B12 is an important cofactor for methionine synthesis and gluconeogenesis. In young ruminants up to 6–8 wk old, the rumen has not been completely developed and rumen microorganisms are not ready to supply vitamin B12. The aim of this research was to determine the potency of mixed rumen bacteria and dietary supplementation of Co and its effect on plasma glucose, blood minerals (Co, Fe, and Zn concentrations, and hematology of pre-weaning twin lambs. Twelve one month-old local twin lambs were assigned to 4 groups in a randomized complete block design. Lambs were fed cow milk at 10% body weight, adjusted weekly for 80 d. Mixed rumen bacteria were offered at 15 mL/d (8.295x1010 cfu. Dietary treatments were: 1 basal diet (Control, 2 basal diet + 1 mg/kg DM cyanocobalamin (VitB12 and 3 basal diet + 1 mg/kg DM of Co + administration of 15 mL mixed rumen bacteria (CoBac. There were no treatment effects on neither plasma glucose and blood mineral concentrations nor hematological profiles. This study demonstrated that pre-weaning twin lambs are not responsive to supplementation of Co and administration of mixed rumen bacteria.

  4. Phases definition in marketing export process

    OpenAIRE

    Rajković Dragan; Kokić Miljko

    2004-01-01

    The result of export marketing process depends on its five phases. The first phase-revision of export capacities, inner view on advantages and defects of company concerning export possibilities. The second phase-identification of export strategy market penetration. The forth phase-preparing for the marketing campaign (action). The fifth phase-carrying out the above mentioned activities. This study shows the structure and contents of the mentioned phases. At the end, export marketing analyzed ...

  5. Markups and Firm-Level Export Status

    DEFF Research Database (Denmark)

    De Loecker, Jan; Warzynski, Frederic

    and export behavior using plant-level data. We find that i) markups are estimated significantly higher when controlling for unobserved productivity, ii) exporters charge on average higher markups and iii) firms' markups increase (decrease) upon export entry (exit).We see these findings as a first step...... in opening up the productivity-export black box, and provide a potential explanation for the big measured productivity premia for firms entering export markets....

  6. Topics in Productivity, Exporting and Outsourced Services

    OpenAIRE

    Kidder, Matthew Benjamin

    2016-01-01

    This dissertation is a collection of three empirical studies using the a survey of Chilean Manufactures. The first two chapters of this dissertation evaluates the productivity impact of exporting and service outsourcing. The last chapter evaluates selection mechanisms into exporting.The first chapter examines productivity and exporting. I find that asymmetric responses, between exporters and non-exporters, to changes in the domestic lending rate can cause propensity-score-matching-differen...

  7. 15 CFR 30.71 - False or fraudulent reporting on or misuse of the Automated Export System.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false False or fraudulent reporting on or misuse of the Automated Export System. 30.71 Section 30.71 Commerce and Foreign Trade Regulations... REGULATIONS Penalties § 30.71 False or fraudulent reporting on or misuse of the Automated Export System. (a...

  8. The Wassenaar Arrangement and Russian High-Tech Export

    Directory of Open Access Journals (Sweden)

    Lilia S. Revenko

    2016-01-01

    Full Text Available The current military and political situation in the world raises the necessity of use by Russia of all existing tools to counter actions targeted against it. Participation of the country in international export control regimes, including the Wassenaar Arrangement (the WA, is one of these tools. Membership in the WA allows to Russia to maintain its international status, to contribute to strengthening of international stability, to ensure the non-targeting of this forum against the country, to participate in the development of decisions affecting its interests. Participation in the WA is also important from the view of modernizations of Russian economy towards transition to a new technological mode accompanied by emergence of new groups of innovative products and modification of existing ones. Control of crossing the country's borders by dual-use goods and services is one of conditions for carrying out their export. The Wassenaar Arrangement was established in 1995 to replace COCOM in order to contribute to regional and international security and stability. A huge work is carried out within the forum aimed at enhancing control over transfers of conventional weapons and high-tech dual-use goods. Russian export control system fully meets requirements of international export control regime, including the WA, and effectively functions. Export of the controlled goods from Russia or their transfer to foreign individuals and legal entities are possible only on the basis of decisions of the Export control Commission of the Russian Federation. The dilemma between the need to support exporters by reducing administrative barriers and the ensuring security interests of the country gain momentum in current stage of scientific-and-technological advance development.

  9. General administrative regulation relating to the Integrated Monitoring and Information System (IMIS) and its application in compliance with the Preventive Radiation Protection Act (StrlSchVG), (AVV-IMIS). As of 27 September 1995

    International Nuclear Information System (INIS)

    1995-01-01

    This general administrative regulation applies to the measuring, communication, compilation, processing, and documentation of data recorded within the IMIS system for the purpose of environmental radioactivity monitoring. (orig./HP) [de

  10. The Effect of Export Tax on Indonesia’s Cocoa Export Competitiveness

    OpenAIRE

    Rifin, Amzul; Nauly, Dahlia

    2013-01-01

    The government of Indonesia implemented an export tax policy on cocoa beans since April 2010 in order to develop cocoa processing industry. The objective of this article is to analyze the effect of export tax on Indonesia’s cocoa export competitiveness. The results indicate that with the implementation of export tax, cocoa export product composition shift from cocoa beans to processed cocoa products. On the other hand, Indonesia’s cocoa export growth is lower than the growth of cocoa world de...

  11. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration.

    Science.gov (United States)

    Limmer, Franziska; Schinner, Elisabeth; Castrop, Hayo; Vitzthum, Helga; Hofmann, Franz; Schlossmann, Jens

    2015-10-01

    Sodium chloride reabsorption in the thick ascending limb of the loop of Henle is mediated by the Na(+)-K(+)-2Cl(-) cotransporter (NKCC2). The loop diuretic furosemide is a potent inhibitor of NKCC2. However, less is known about the mechanism regulating the electrolyte transporter. Considering the well-established effects of nitric oxide on NKCC2 activity, cGMP is likely involved in this regulation. cGMP-dependent protein kinase I (cGKI; PKGI) is a cGMP target protein that phosphorylates different substrates after activation through cGMP. We investigated the potential correlation between the cGMP/cGKI pathway and NKCC2 regulation. We treated wild-type (wt) and cGKIα-rescue mice with furosemide. cGKIα-rescue mice expressed cGKIα only under the control of the smooth muscle-specific transgelin (SM22) promoter in a cGKI deficient background. Furosemide treatment increased the urine excretion of sodium and chloride in cGKIα-rescue mice compared to that in wt mice. We analyzed the phosphorylation of NKCC2 by western blotting and immunostaining using the phosphospecific antibody R5. The administration of furosemide significantly increased the phosphorylated NKCC2 signal in wt but not in cGKIα-rescue mice. NKCC2 activation led to its phosphorylation and membrane translocation. To examine whether cGKI was involved in this process, we analyzed vasodilator-stimulated phosphoprotein, which is phosphorylated by cGKI. Furosemide injection resulted in increased vasodilator-stimulated phosphoprotein phosphorylation in wt mice. We hypothesize that furosemide administration activated cGKI, leading to NKCC2 phosphorylation and membrane translocation. This cGKI-mediated pathway could be a mechanism to compensate for the inhibitory effect of furosemide on NKCC2. © 2015 FEBS.

  12. Muscarinic receptor plasticity in the brain of senescent rats: down-regulation after repeated administration of diisopropyl fluorophosphate

    International Nuclear Information System (INIS)

    Pintor, A.; Fortuna, S.; Volpe, M.T.; Michalek, H.

    1988-01-01

    Potential age-related differences in the response of Fischer 344 rats to subchronic treatment with diisopropylfluorophosphate (DFP) were evaluated in terms of brain cholinesterase (ChE) inhibition and muscarinic receptor sites. Male 3- and 24-month old rats were sc injected with sublethal doses of DFP for 2 weeks and killed 48 hrs after the last treatment. In the cerebral cortex, hippocampus and striatum of control rats a significant age-related reduction of ChE and of maximum number of 3 H-QNB binding sites (Bmax) was observed. The administration of DFP to senescent rats resulted in more pronounced and longer lasting syndrome of cholinergic stimulation, with marked body weight loss and 60% mortality. The percentage inhibition of brain ChE induced by DFP did not differ between young and senescent rats. As expected, in young rats DFP caused a significant decrease of Bmax, which in the cerebral cortex reached about 40%. In the surviving senescent rats, the percentage decrease of Bmax due to DFP with respect to age-matched controls was very similar to that of young animals, especially in the cerebral cortex. Thus there is great variability in the response of aged rats to DFP treatment, from total failure of adaptive mechanisms resulting in death to considerable muscarinic receptor plasticity

  13. Controlling prescription drug costs: regulation and the role of interest groups in Medicare and the Veterans Health Administration.

    Science.gov (United States)

    Frakt, Austin B; Pizer, Steven D; Hendricks, Ann M

    2008-12-01

    Medicare and the Veterans Health Administration (VA) both finance large outpatient prescription drug programs, though in very different ways. In the ongoing debate on how to control Medicare spending, some suggest that Medicare should negotiate directly with drug manufacturers, as the VA does. In this article we relate the role of interest groups to policy differences between Medicare and the VA and, in doing so, explain why such a large change to the Medicare drug program is unlikely. We argue that key policy differences are attributable to stable differences in interest group involvement. While this stability makes major changes in Medicare unlikely, it suggests the possibility of leveraging VA drug purchasing to achieve savings in Medicare. This could be done through a VA-administered drug-only benefit for Medicare-enrolled veterans. Such a partnership could incorporate key elements of both programs: capacity to accept large numbers of enrollees (like Medicare) and leverage to negotiate prescription drug prices (like the VA). Moreover, it could be implemented at no cost to the VA while achieving savings for Medicare and beneficiaries.

  14. Muscarinic receptor plasticity in the brain of senescent rats: down-regulation after repeated administration of diisopropyl fluorophosphate

    Energy Technology Data Exchange (ETDEWEB)

    Pintor, A.; Fortuna, S.; Volpe, M.T.; Michalek, H.

    1988-01-01

    Potential age-related differences in the response of Fischer 344 rats to subchronic treatment with diisopropylfluorophosphate (DFP) were evaluated in terms of brain cholinesterase (ChE) inhibition and muscarinic receptor sites. Male 3- and 24-month old rats were sc injected with sublethal doses of DFP for 2 weeks and killed 48 hrs after the last treatment. In the cerebral cortex, hippocampus and striatum of control rats a significant age-related reduction of ChE and of maximum number of /sup 3/H-QNB binding sites (Bmax) was observed. The administration of DFP to senescent rats resulted in more pronounced and longer lasting syndrome of cholinergic stimulation, with marked body weight loss and 60% mortality. The percentage inhibition of brain ChE induced by DFP did not differ between young and senescent rats. As expected, in young rats DFP caused a significant decrease of Bmax, which in the cerebral cortex reached about 40%. In the surviving senescent rats, the percentage decrease of Bmax due to DFP with respect to age-matched controls was very similar to that of young animals, especially in the cerebral cortex. Thus there is great variability in the response of aged rats to DFP treatment, from total failure of adaptive mechanisms resulting in death to considerable muscarinic receptor plasticity.

  15. Marketing technologies for building competitiveness of companies export

    Directory of Open Access Journals (Sweden)

    Tatyana Tsygankova

    2017-03-01

    Full Text Available In context of post-industrial development of global economy, escalating competition in international goods markets, the definition of competitive export is proposed based upon both existing criteria – sustainability, effectiveness, adaptivity and fair competition, and on those described in the work – ecological performance, service maintenance, brand awareness and high technology. Given that, it is proved that with the aim of detailing the elements of competitive export, the latter should be typified depending upon the performer (export competitiveness of a company, country, region and subject (export competitiveness of goods, services, rights upon intellectual property objects, keeping in mind universal and specific features of export criteria proposed to be characterised through a range of indices on corporate and state levels. Groups of factors affecting export competitiveness building are systematized (institutional, financial and economic, marketing, foreign trade, scientific and technological, resource-related and social and ecological. Marketing technologies are typified on corporate level under the following criteria: novelty, object, creative component availability, internationalization stages, international marketing forms, digitalization level, management functions, customer-centreness scale, international marketing activity stages, financial security, specific features of intercorporate coordination. The practice of applying international marketing technologies by companies is investigated. In context of necessity to overcome crisis phenomena and increase competitive export volume, an assessment is made of integrating national manufacturing into regulated global chains of creating added value with the relevant rating, in particular, depending upon the available potential, minimality of technical and organizational changes, marketing relevancy, enabling to determine the manufacturing areas most prepared to cooperation, and

  16. Quality, Export and Economic Growth

    DEFF Research Database (Denmark)

    Madsen, Erik Strøjer; Pedersen, Kurt

    1998-01-01

    in an international context. The paper, therefore, addresses the complicated interactions between economic growth, export performance and quality. The contribution of the paper, compared to other growth accounting research, is the inclusion of quality data, quality being a significant mirror of technological...... development. The countries covered by the research represent a wide variation in terms of economic development, from poor LDC's to the most developed industrial nations. The empirical results reveal a probable strong relationship between quality/price and export growth as well as economic growth. This new...

  17. Creative destruction and export patterns

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Kvedaras, Virmantas; Nielsen, Jørgen Ulff-Møller

    2014-01-01

    varieties obsolete. For a given technology (variety) production costs decrease after an infant period due to learning. While all firms are assumed to be symmetric in a life-cycle perspective, at a given point in time firms of different ages differ in productivity, firm size, product quality, and export...... behavior. The model highlights a process of creative destruction, which allows firms to produce in a finite span of periods determined by the intensity of product and process innovations. The model predicts a wide range of export behavior of the individual firm during its life cycle depending...

  18. Government experience in nuclear power plant export financing

    International Nuclear Information System (INIS)

    Kalbitz, K.

    1976-01-01

    Because the long-term funds at the disposal of the commercial banks were insufficient to make available the amounts required for the exportation of nuclear power plants, it was necessary to make available long-term funds of the mortgage banks. On account of the strict regulations governing the lending operations of such banks, it was, however, necessary to introduce a Federal guarantee which covers 100% of the contract value in each case. On balance, however, the Federal Government does not take over any additional risks, because recourse may be taken to the commercial banks, which are liable for all additional payments under the credit arrangement having arisen from the improvement of the guarantee in favour of the mortgage banks. This has resulted in a considerable improvement of the export financing system which, of course, is for benefit of other major export projects too. (HP) [de

  19. 75 FR 44761 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-07-29

    ... sales prices and/or minimum target sales prices, and other terms of sales in the Export Markets... canned salmon in the Export Markets, selling strategies for the Export Markets, sales for the Export... described below for the following Export Trade and Export Markets: Export Trade Products Shelf stable non...

  20. Export-Led Growth Hypothesis: Evidence from Agricultural Exports ...

    African Journals Online (AJOL)

    This study examines the nature and direction of causality in Tanzania between economic growth and agricultural exports along with some selected variables such as labour force and domestic investment. The analysis for this study was carried out using time series data for the period of 1980 to 2013. The data series were ...

  1. Export of radiopharmaceuticals and establishment of export base of cyclotron

    International Nuclear Information System (INIS)

    Jung, Kyungil; Kim, Youngsik

    2006-01-01

    Sam young Unit ech has seized an opportunity to advance into the radiopharmaceuticals market through successful transfer of radiopharmaceuticals manufacturing technology and medical cyclotron, an original technology in nuclear medicine that is the core of less developed areas in nuclear-related fields. The company has continued to push for research development and establishment of market base through industry-academia-research center cooperation with an aim to complement relatively less developed domestic technology and market than in advanced countries, and is making efforts to establish export base in the overseas market based on stabilized supply in the domestic market. As for radiopharmaceuticals, the company is exporting Tc-99m generator to Vietnam, Thailand and the Philippines and preparing itself to export manufacture facilities for Tc-99m generator to Syria and Kazakhstan. In addition, it plans to export 13Mev Cyclotron that has been commercialized after being developed in the domestic market to the U. S. The company plans to grow up to play a pivotal role in the domestic RT area by conducting proactive business activities with an aim to revitalize the domestic market and further domestic original technologies and products in the global market

  2. 77 FR 8807 - President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2012-02-15

    ... diplomatic or trading relations and of controlling trade for national security and foreign policy reasons.... Welcome and remarks by Chairman and Vice Chair. 2. Presentation of Papers or Comments by the Public. 3. Review of Field Hearing. 4. Discussion/Status of 2012 Workplan. 5. Subcommittee Breakout Sessions. 6...

  3. 76 FR 66685 - President's Export Council Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2011-10-27

    ... public. 4. Review of Deliverables for the PEC. 5. Discussion of 2012 Workplan. 6. Subcommittee Breakout... which the United States has diplomatic or trading relations and of controlling trade for national....gov , no later than, November 7, 2011. A limited number of seats will be available for the public...

  4. Determinants of Short-Term Export Performance in Pakistan

    OpenAIRE

    Subhani, Muhammad Imtiaz; Osman, Ms.Amber; Habib, Sukaina

    2010-01-01

    This research investigates the interdependency between independent (Increase of pricing strategy adaptation, Increase of export intensity, Firm's commitment to exporting, Export market development, Export market competition, Past Pricing Strategy Adaptation, Past Export Performance Satisfaction, Past Export Intensity, Export market distance) and dependent variables (i.e. Expected Short-Term Export Performance improvement) of export performance. The framework is tested via a survey through que...

  5. Differential regulation of proopiomelanocortin (POMC mRNA expression in hypothalamus and anterior pituitary following repeated cyanamide with ethanol administration

    Directory of Open Access Journals (Sweden)

    Kinoshita Hiroshi

    2005-01-01

    Full Text Available Background/Aim. We have investigated proopiomelanocortin (POMC mRNA expression in the arcuate nucleus of the hypothalamus (ARC and the anterior lobe of the pituitary (AL following repeated cyanamide-ethanol reaction (CER. Methods. Adult male Sprague -Dawley rats (250 −290 gr were housed in a temperature and humidity controlled environment with free access to food and water. Four experimental groups were used as follows: saline (as control, cyanamide alone, ethanol alone and ethanol with cyanamide. The animals received daily intraperitoneal injections (i.p. of cyanamide (10mg/kg, 60 min before ethanol dosing with or without ethanol (1g/kg for 5 consecutive days, and were sacrificed 60 min after the last dosing of ethanol. The results were presented as the mean ± SEM for each group. All groups within each data set were compared by one-way ANOVA followed by Fisher PLSD test for multiple comparisons. A value of p<0.05 was considered significant. Results. The POMC mRNA levels in ARC were significantly decreased with cyanamide compared to the control and ethanol alone (p<0.05 and p<0.05 respectively, but increased in AL following repeated CER. Conclusion. We speculate that this differential regulation of POMC mRNA expression may be partially involved in the preventive effects on alcohol intake in response to CER.

  6. Mergers, Acquisitions and Export Competitiveness: Experience of Indian Manufacturing Sector

    Directory of Open Access Journals (Sweden)

    Mishra Pulak

    2012-03-01

    Full Text Available In the context of economic reforms in general and subsequent wave of M&A in particular, this paper attempts to examine the impact of M&A on the export competitiveness of firms in the Indian manufacturing sector. By using a panel dataset of 33 industries from the period of 2000-01 to 2007-08, it is found that, the wave of M&A has enhanced the export competitiveness of firms. The industries with larger number of M&A have greater penetration in the international market. The other factors that have significantly contributed to export competitiveness include the presence of MNCs and import of foreign technology. Export competiveness is higher in the industries that have larger presence of MNCs and greater foreign technology purchase intensity. On the other hand, industries with higher capital intensity or greater selling efforts by firms have limited penetration in the international market. However, this paper did not find any significant influence of market concentration, competition from imports, in-house efforts, or profitability on export competitiveness of firms. Therefore, the findings from this paper have important policy implications in relation to the regulation of M&A and entry of MNCs as well as the import of capital goods.

  7. RNA Export through the NPC in Eukaryotes.

    Science.gov (United States)

    Okamura, Masumi; Inose, Haruko; Masuda, Seiji

    2015-03-20

    In eukaryotic cells, RNAs are transcribed in the nucleus and exported to the cytoplasm through the nuclear pore complex. The RNA molecules that are exported from the nucleus into the cytoplasm include messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), micro RNAs (miRNAs), and viral mRNAs. Each RNA is transported by a specific nuclear export receptor. It is believed that most of the mRNAs are exported by Nxf1 (Mex67 in yeast), whereas rRNAs, snRNAs, and a certain subset of mRNAs are exported in a Crm1/Xpo1-dependent manner. tRNAs and miRNAs are exported by Xpot and Xpo5. However, multiple export receptors are involved in the export of some RNAs, such as 60S ribosomal subunit. In addition to these export receptors, some adapter proteins are required to export RNAs. The RNA export system of eukaryotic cells is also used by several types of RNA virus that depend on the machineries of the host cell in the nucleus for replication of their genome, therefore this review describes the RNA export system of two representative viruses. We also discuss the NPC anchoring-dependent mRNA export factors that directly recruit specific genes to the NPC.

  8. Nuclear Export of Messenger RNA

    Directory of Open Access Journals (Sweden)

    Jun Katahira

    2015-03-01

    Full Text Available Transport of messenger RNA (mRNA from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex.

  9. On American Cultural Exportation Strategy

    Institute of Scientific and Technical Information of China (English)

    李德俊

    2015-01-01

    American government has been attaching great importance to the role that cultural values plays in international relationships and Culture Exportation has gradually become one of the important parts of American diplomatic strategy. This strategy,which is propelled by a variety of impetuses and conducted by different approaches,is mainly aimed to serve the overall national interests of the United States.

  10. On American Cultural Exportation Strategy

    Institute of Scientific and Technical Information of China (English)

    李德俊

    2015-01-01

    American government has been attaching great importance to the role that cultural values plays in international relationships and Culture Exportation has gradually become one of the important parts of American diplomatic strategy.This strategy,which is propelled by a variety of impetuses and conducted by different approaches,is mainly aimed to serve the overall national interests of the United States.

  11. Nuclear Export of Messenger RNA

    Science.gov (United States)

    Katahira, Jun

    2015-01-01

    Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex. PMID:25836925

  12. Export Intermediation and the Internet

    DEFF Research Database (Denmark)

    Andersen, Poul Houman

    2005-01-01

    It is claimed that the remarkable growth in numbers of connected firms to the Internet marks a radical shift in current organisation of international business channels. For export intermediaries these new possibilities pose a threat to their current market position. However, virtual market presence...

  13. Revision of Import and Export Requirements for Controlled Substances, Listed Chemicals, and Tableting and Encapsulating Machines, Including Changes To Implement the International Trade Data System (ITDS); Revision of Reporting Requirements for Domestic Transactions in Listed Chemicals and Tableting and Encapsulating Machines; and Technical Amendments. Final rule.

    Science.gov (United States)

    2016-12-30

    The Drug Enforcement Administration is updating its regulations for the import and export of tableting and encapsulating machines, controlled substances, and listed chemicals, and its regulations relating to reports required for domestic transactions in listed chemicals, gamma-hydroxybutyric acid, and tableting and encapsulating machines. In accordance with Executive Order 13563, the Drug Enforcement Administration has reviewed its import and export regulations and reporting requirements for domestic transactions in listed chemicals (and gamma-hydroxybutyric acid) and tableting and encapsulating machines, and evaluated them for clarity, consistency, continued accuracy, and effectiveness. The amendments clarify certain policies and reflect current procedures and technological advancements. The amendments also allow for the implementation, as applicable to tableting and encapsulating machines, controlled substances, and listed chemicals, of the President's Executive Order 13659 on streamlining the export/import process and requiring the government-wide utilization of the International Trade Data System (ITDS). This rule additionally contains amendments that implement recent changes to the Controlled Substances Import and Export Act (CSIEA) for reexportation of controlled substances among members of the European Economic Area made by the Improving Regulatory Transparency for New Medical Therapies Act. The rule also includes additional substantive and technical and stylistic amendments.

  14. The role of the USNRC in power reactor exports. Legal and procedural aspects

    International Nuclear Information System (INIS)

    Shapar, H.K.; Stoiber, C.R.

    1978-01-01

    I. Background on the role of NRC in nuclear export activities. The United States Nuclear Regulatory Commission, created in January 1975 to assume the licensing and regulatory responsibilities of the former Atomic Energy Commission, has final licensing authority over US nuclear reactor exports. Independent of direct Presidential control, the Commission gives great weight to Executive Branch views on national security and foreign policy issues. II. The nuclear export review process. Procedures for NRC review of nuclear export licence applications include referral to the Executive Branch for a co-ordinated expression of agency views; analysis of the record by the NRC staff; and final Commission licensing decision based on consideration of safeguards, agreements and understandings to assure that US exports will be used only for their intended peaceful purposes. III. NRC's proposed export/import licensing regulations. NRC has recently proposed to consolidate and simplify all of its export and import licensing provisions into a new Part 110 for the convenience of the public - both US and foreign. IV. Public participation in nuclear reactor export licensing. In the past two years, after formal requests by domestic and foreign interest groups, the NRC has developed procedures for direct public participation in its export licensing proceedings. V. Statutory licensing requirements. During the past two years, the NRC has refined and particularized the extremely general 'common defence and security' standard for export licences set forth in the 1954 Atomic Energy Act. Eight questions routinely posed to the Executive Branch in reviewing licence applications has given content to Commission export decisions. Recently enacted non-proliferation legislation gives congressional recognition to even more specific, mandatory nuclear export licensing criteria

  15. Export markets for nuclear technology

    International Nuclear Information System (INIS)

    Huettl, A.J.

    1985-01-01

    By late 1984, nuclear power plants were in operation or under construction in 32 countries of the globe. An additional six countries had concrete plans for building nuclear power plants. Of these 38 countries, ten have shown that they posses the necessary know-how and the technical facilities to plan and build nuclear power plants practically on their own. Seven of these ten countries have already acted as exporters of nuclear power plants, albeit with very different degrees of market penetration. In addition, there have been a number of countries for quite some time whose industries have managed to manufacture many important nuclear power plant components. Their high level of technical development and the problems frequently encountered in export financing have made them very attractive partners of the true exporters of nuclear power plants. For the future, it must be expected that some of the countries which have so far limited their efforts to the construction of nuclear power plants at home will also develop into exporters of nuclear technology. The report contains a survey of the range of nuclear products available, a list of reactor vendors, reactor lines, and data on the economics of electricity generation in nuclear plants. It then goes on to offer detailed descriptions of the market and the demand situation. Interesting chapters are devoted to the selection criteria applied by importing countries, to financing problems, and to the influences exerted by the political environment. A realistic forecast is attempted in order to make a quantitative analysis of possible export contracts up until the year 2000. (orig.) [de

  16. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration

    DEFF Research Database (Denmark)

    Licht, Cecilie Löe; Marcussen, Anders Bue; Wegener, Gregers

    2009-01-01

    The 5-hydroxytryptamine (5-HT(4)) receptor may be implicated in depression and is a new potential target for antidepressant treatment. We have investigated the brain 5-HT(4) receptor [(3)H]SB207145 binding in the Flinders Sensitive Line rat depression model by quantitative receptor autoradiography....... In the Flinders Sensitive Line, the 5-HT(4) receptor and 5-HT transporter binding were decreased in the dorsal and ventral hippocampus, and the changes in binding were directly correlated within the dorsal hippocampus. Chronic but not acute paroxetine administration caused a 16-47% down-regulation of 5-HT(4......) receptor binding in all regions evaluated including the basal ganglia and hippocampus, while 5-HT depletion increased the 5-HT(4) receptor binding in the dorsal hippocampus, hypothalamus, and lateral globus pallidus. In comparison, the 5-HT(2A) receptor binding was decreased in the frontal and cingulate...

  17. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity.

    Science.gov (United States)

    Kim, Jongwan; Yun, Eun-Young; Quan, Fu-Shi; Park, Seung-Won; Goo, Tae-Won

    2017-01-01

    The α -glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression. We conclude that DNJ may reduce obesity by moderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS).

  18. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity

    Directory of Open Access Journals (Sweden)

    Jongwan Kim

    2017-01-01

    Full Text Available The α-glucosidase inhibitor, 1-deoxynojirimycin (DNJ, is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2/signal transducers and activators of transcription 3 (STAT3 signaling pathway to cause appetite suppression. We conclude that DNJ may reduce obesity by moderating feeding behavior and ER stress in the hypothalamic portion of the central nervous system (CNS.

  19. Legal and administrative regulation of the petroleum industry in Trinidad and Tobago: a study of law and policy in petroleum development

    Energy Technology Data Exchange (ETDEWEB)

    Khan, K I.F.

    1984-01-01

    This work has, through an in-depth assessment of the law and institutions employed in the petroleum industry in Trinidad and Tobago, evaluated their viability in achieving declared state objectives and in providing a legal and administrative framework for regulating this industry. After considering the evolution of laws, policies, and institutions, the work focuses mainly on the petroleum contract, the national oil company, taxation of petroleum operations, and the ways of integrating the industry into the national economy and achieving an effective transfer of technology. These central areas are examined from a policy perspective which looks at their role, inter alia, as instruments of development, for securing active state participation, in the creation of an efficient and effective regulatory infrastructure and in allowing an optimum development of the resources, in the interest of the state. Further this examination provides the basis for suggested reforms and improvements to the existing model.

  20. Administrative contracts

    Directory of Open Access Journals (Sweden)

    Vukićević-Petković Milica

    2015-01-01

    Full Text Available Administrative contracts are a special type of contract where usually one of the contracting parties is a public law body and which is concluded for the performance of public service and the realization of a public interest. They go a long way since its inception to its eventual final acceptance of all the legal systems. One of the enduring characteristics of this type of contract is their disquised or unnoticed existence. This is why only monitoring their development may lead to a complete understanding of the importance and essence of this institution as well as the need for its complete legal regulation.

  1. US Export Controls and Technology Transfer Requirements: A UK Perspective

    Science.gov (United States)

    2010-05-01

    34 (La Franchi , 2006). Such requirements make it difficult for partners to participate and generate a large administrative burden on team members, who...if this critical impediment to enhanced cooperation is to be removed. The U.S. export control system is broken; its technology transfer rules ...Retrieved April 3, 2009, from http://www.jsf.mil/news/news2009.htm La Franchi , P. (2006, July 4). Australia demands JSF resolution. Flight International

  2. Australian coal exports - threat to market share

    Energy Technology Data Exchange (ETDEWEB)

    James, P

    1989-10-01

    Australian coal exports fell 3% for the fiscal year ending June 1989, but at just under 100mt, they make Australia the world's leading coal exporter. Figures for production, consumption and exports are given. Industrial and structural changes within the industry are discussed. It is concluded that the industry and unions must improve structures and communication if potential production and exports are to be achieved. 2 figs.

  3. Chinese Competition and Brazilian Exports of Manufactures

    OpenAIRE

    Jenkins, Rhys

    2014-01-01

    In recent years concerns have been raised over the impact of Chinese competition on Latin American exports, particularly those from Mexico. This article shows that Brazilian manufactured exports too have been negatively affected, and that this has been reflected in the “primarization” of Brazilian exports and a declining share in the import markets of its major customers. A variety of different indicators were used to analyse the extent to which Brazilian exports have faced competition from C...

  4. Export channel pricing management for integrated solutions

    OpenAIRE

    Roine, Henna; Sainio, Liisa-Maija; Saarenketo, Sami

    2012-01-01

    This article studies systems integrators' export channel pricing management for integrated solutions. We find support from our empirical case study for the notion that a systems integrator's export channel pricing strategy is multidimensional and dependent on international pricing environment and partner characteristics and that export partnerships have unique implications on a systems integrator's pricing process. The results show that giving up pricing control in export channel context may ...

  5. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.

    Science.gov (United States)

    Kenny, Paul J; Chartoff, Elena; Roberto, Marisa; Carlezon, William A; Markou, Athina

    2009-01-01

    Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing properties, which motivate consumption of the drug. Here we show that the competitive N-methyl-D-aspartate (NMDA) receptor antagonist LY235959 (0.5-2.5 mg per kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (ICSS) thresholds usually observed after experimenter-administered (0.25 mg per kg) or intravenously self-administered (0.03 mg per kg per infusion) nicotine injections. The highest LY235959 dose (5 mg per kg) tested reversed the hedonic valence of nicotine from positive to negative, reflected in nicotine-induced elevations of ICSS thresholds. LY235959 doses that reversed nicotine-induced lowering of ICSS thresholds also markedly decreased nicotine self-administration without altering responding for food reinforcement, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor antagonist NBQX had no effects on nicotine intake. In addition, nicotine self-administration upregulated NMDA receptor subunit expression in the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA), suggesting important interactions between nicotine and the NMDA receptor. Furthermore, nicotine (1 microM) increased NMDA receptor-mediated excitatory postsynaptic currents in rat CeA slices, similar to its previously described effects in the VTA. Finally, infusion of LY235959 (0.1-10 ng per side) into the CeA or VTA decreased nicotine self-administration. Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug.

  6. Exporting nuclear engineering and the government's viewpoint

    International Nuclear Information System (INIS)

    Schill, H.

    1986-01-01

    The reasons for the government's positive attitude to nuclear engineering exports are explained, especially with regard to them being a compensation of the decreasing domestic demand. The federal government considers such exports to be necessary and correct for economical and energy-political reasons. Their contribution reaches from accompanying measures to the provision of state guarantees of export financing activities. (UA) [de

  7. Firm-level volatility and exports

    NARCIS (Netherlands)

    Vannoorenberghe, G.C.L.

    2012-01-01

    This paper shows that the share of exports in the total sales of a firm has a positive and substantial impact on the volatility of its sales. Decomposing the volatility of sales of exporters between their domestic and export markets, I show using an identification strategy based on a firm-specific

  8. 27 CFR 28.216 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.216 Section 28.216 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.216...

  9. 77 FR 16768 - Export Sales Reporting Requirements

    Science.gov (United States)

    2012-03-22

    ... DEPARTMENT OF AGRICULTURE Office of the Secretary 7 CFR Part 20 RIN 0551-AA70 Export Sales... Sales Reporting Requirements, is being withdrawn. The Foreign Agricultural Service (FAS) is currently...: Contact Peter W. Burr, Branch Chief, Export Sales Reporting Branch, Import Policies and Export Reporting...

  10. 27 CFR 28.193 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.193... Drawback Filing of Notice and Removal § 28.193 Export marks. In addition to the marks and brands required... chapter, the exporter shall mark the word “Export” on the Government side of each case or Government head...

  11. 77 FR 73627 - 2012 LNG Export Study

    Science.gov (United States)

    2012-12-11

    ... DEPARTMENT OF ENERGY 2012 LNG Export Study AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of availability of 2012 LNG Export Study and request for comments. Freeport LNG Expansion, L.P. [FE Docket No. 10-161-LNG] and FLNG Liquefaction, LLC. Lake Charles Exports, LLC.... [FE Docket...

  12. 27 CFR 28.223 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.223... Export marks. In addition to the marks and brands required to be placed on kegs, barrels, cases, crates... “Export” on each container or case before removal for export, for use on vessels or aircraft, or for...

  13. 75 FR 69573 - Export Enforcement Coordination Center

    Science.gov (United States)

    2010-11-15

    ... Export Enforcement Coordination Center By the authority vested in me as President by the Constitution and... enforcement of United States export control laws and enhanced intelligence exchange in support of such enforcement efforts, it is hereby ordered as follows: Section 1. Policy. Export controls are critical to...

  14. 27 CFR 28.154 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.154..., for Exportation or Transfer to a Foreign-Trade Zone § 28.154 Export marks. In addition to the marks... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

  15. 76 FR 66693 - President's Export Council: Meeting of the President's Export Council

    Science.gov (United States)

    2011-10-27

    .... ACTION: Notice of an open meeting. SUMMARY: The President's Export Council will hold a meeting to discuss.... exports, jobs, and growth. DATES: November 16, 2011 at 9:30 a.m. (ET) ADDRESSES: The President's Export... on December 20, 1973 to advise the President on matters relating to U.S. export trade and report to...

  16. 76 FR 9550 - President's Export Council: Meeting of the President's Export Council

    Science.gov (United States)

    2011-02-18

    .... ACTION: Notice of an open meeting. SUMMARY: The President's Export Council will hold a meeting to discuss.... exports, jobs, and growth. DATES: March 11, 2011 at 9:30 a.m. (ET). ADDRESSES: The President's Export... on December 20, 1973 to advise the President on matters relating to U.S. export trade and report to...

  17. Implementing international experience in promoting agricultural products to foreign markets: the Russian export strategy

    Directory of Open Access Journals (Sweden)

    Lilia S. Revenko

    2017-01-01

    Full Text Available Almost all countries in the world actively regulate both import and export of agricultural products, however this process is very conflictгфд because of acute contradictions on the market. They are associated with the changing conditions of production, increase of attention of the world community to the food securitysituation, change of the used resources efficiency level, competition enhancement. Both internal and external components of agricultural producers support are important for Russia. That means the regulation should be aimed at meeting the needs of the domestic market and at increasing competitiveness of Russian products abroad. The development of the Russian export strategy for agricultural products is currently very important. This problem is closely related to the general subject of the agricultural productiondevelopment, but it has an explicit specific character. Inthiscontextexperienceofforeigncountriesisinteresting. Almost all tools of export regulation existing in the world practice are used in the foreign practice of export regulation of agricultural raw materials and food. Stimulation measures prevail in regards to the coverage of commodity items, number of episodes involving the use of agricultural export regulationmeasures, effectiveness of impact to the national agricultural sector. Holistic strategies of agricultural export development are not a widespread phenomenon abroad at the present stage of the world economy development. Their existence is typical for countries with a high level of food self-sufficiency. Special programs where export component is a harmonically built-in element are now more widely spread. Export development programs of the developed countries include a range of measures to maintain the target income level of producers and to maintain procurement and consumer prices. Export policy of the developing countries has a subordinated importance and is considered as one of the levels to develop national

  18. A political economy of China's export restrictions on rare earth elements

    Energy Technology Data Exchange (ETDEWEB)

    Pothen, Frank [Zentrum fuer Europaeische Wirtschaftsforschung GmbH (ZEW), Mannheim (Germany); Fink, Kilian [Frankfurt Univ. (Germany)

    2015-04-20

    We investigate why governments restrict exports of exotic raw materials taking rare earth elements as a case study. Trade restrictions on exotic materials do not have immediate macroeconomic effects. Relocating rare earth intensive industries is found to be the main reason behind China's export barriers. They are part of a more extensive strategy aiming at creating comparative advantages in these sectors and at overcoming path dependencies. Moreover, export barriers serve as a second-best instrument to reduce pollution and to slow down the depletion of exhaustible resources. Growing domestic rare earth consumption renders those increasingly ineffective. Rising reliance on mine-site regulation indicates that this fact is taken into account. Rare earth extraction is dominated by a few large companies; the demand side is dispersed. That speaks against successful lobbying for export restrictions. It appears as if the export barriers are set up to compensate mining firms.

  19. 12 CFR 404.11 - Administrative appeal.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Administrative appeal. 404.11 Section 404.11 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Procedures for Disclosure of Records Under the Freedom of Information Act. § 404.11 Administrative appeal. (a) General...

  20. Human Capital and Wages in Exporting Firms

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Skaksen, Jan Rose

    This paper studies the link between a firms education level, export performance and wages of its workers. We argue that firms may escape intense competition in international markets by using high skilled workers to differentiate their products. This story is consistent with our empirical results....... Using a very rich matched worker-firm longitudinal dataset we find that firms with high export intensities pay higher wages. However, an interaction term between export intensity and skill intensity has a positive impact on wages and it absorbs the direct effect of the export intensity. That is, we find...... an export wage premium, but it accrues to workers in firms with high skill intensities...

  1. Phases definition in marketing export process

    Directory of Open Access Journals (Sweden)

    Rajković Dragan

    2004-01-01

    Full Text Available The result of export marketing process depends on its five phases. The first phase-revision of export capacities, inner view on advantages and defects of company concerning export possibilities. The second phase-identification of export strategy market penetration. The forth phase-preparing for the marketing campaign (action. The fifth phase-carrying out the above mentioned activities. This study shows the structure and contents of the mentioned phases. At the end, export marketing analyzed DPV is given as the example.

  2. Core labour standards and exports

    OpenAIRE

    Siroën, Jean-Marc

    2017-01-01

    (english) Core labour standards defined by the ILO in 1998 are universal, but applied very differently across countries. Compliance is much higher in high income countries. However, the causality between improved labour standards and economic growth remains a controversial issue. Export-led growth strategies might encourage developing countries to curb the process of standards improvement. In this way, they can raise the volume of their unskilled labour endowments (child and/or forced labour)...

  3. Introduction to Technology Export License of Nuclear Facility

    International Nuclear Information System (INIS)

    Seo, Hana; Lee, Chansuh; Shin, Donghoon

    2014-01-01

    In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry

  4. Introduction to Technology Export License of Nuclear Facility

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Hana; Lee, Chansuh; Shin, Donghoon [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

    2014-05-15

    In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry.

  5. Imports, exports, and Alberta's transmission system impact on price fluctuation

    International Nuclear Information System (INIS)

    Johnson, K.

    2002-01-01

    The roles, responsibilities and objectives of ESBI, a private for-profit company, appointed by the Alberta Government to be the Independent Transmission Administrator in the province, is sketched, prior to a discussion of price volatility in electricity, Alberta interconnections, intertie issues, the economic theory and the reality impact on prices. Given that imports and exports constitute a relatively small proportion of total generation or load in Alberta, price volatility is considered to have been only minimally affected by imports/exports. In contrast, transmission constraints, i.e. the limits on physical capacity of the existing transmission system to accommodate all desired transactions, have significant impact on imports/exports. Factors underlying constraints and price volatility such as uncertainty of generation dispatch, leading to reduced interest to invest, which in turn leads to scarce capacity for imports/exports, and the actions required to reduce uncertainty and address other issues such as congestion management, tariff design and the creation of regional transmission organizations, are also discussed to provide further clarification of the issues. It is suggested that these and other related issues need to be resolved to provide the clarity around transmission access and the tools required to manage price fluctuations

  6. The Chinese Export Displacement Effect Revisited

    DEFF Research Database (Denmark)

    Elleby, Christian; Yu, Wusheng; Yu, Qian

    China’s global export share has increased dramatically over the past decades. This development has prompted an empirical literature on whether Chinese exports displace those originated from elsewhere in various destination markets. In this paper we focus on the growth of China’s exports to the East...... African Community (EAC) countries and show how it has affected exports from the European Union (EU) to the EAC. Our main contribution to the literature on the displacement effect of Chinese exports is a set of total and relative displacement estimates based on different specifications of the gravity model...... where we control for country-year fixed effects so as to avoid the “gold medal mistake” of not accounting for time varying “multilateral resistance”. Our findings do not support the hypothesis that Chinese exports have displaced exports from other countries in general. Nor do they support the hypothesis...

  7. Perceived impediments to export involvement among small and medium sized firms : non-exporters perspective

    Directory of Open Access Journals (Sweden)

    Mercy Mpinganjira

    2011-12-01

    Full Text Available Purpose: The main purpose of this paper is to examine perceived impediments to export involvement among non-exporting small and medium sized firms (SME's in Malawi. The study also examines levels of interest in exporting among the firms. Problem investigated: Many countries have programs aimed at promoting export involvement among SME's. Despite this, most SME's continue to ignore exporting as a viable business strategy. Information on perceived impediments to export involvement especially from the non-exporters' perspective is often lacking hence the need for this study. Methodology: Data was collected from 80 owner managers of non-exporting SME's. A structured questionnaire was the main instrument used to collect data. Personal interviews were also held with managers for the purposes of probing their answers to the questions in the questionnaire. Statistical Package for Social Science (SPSS version 18 was used to analyse the quantitative data obtained from use of the structured questionnaire. Qualitative data obtained through personal interviews was analysed used thematic analysis. Findings: The findings of the study showed significant levels of interest in exporting among the firms. The majority of the owner managers indicated willingness to exploit export opportunities that may be readily available to them. The findings however showed that just over half of the respondents had discussed or investigated the possibility of exporting before. On impediments to exporting, the findings showed that managers perceive many factors as important impediments to their firm's involvement in exporting. The top two most important impediments were internal to the firm and related to human resource issues. They included insufficient knowledge about export opportunities and lack of personnel knowledgeable in exporting. Originality and value of the research: A review of literature shows that most export promotion studies tend to focus more on issues relating to

  8. A comparative study on export control systems of nuclear technology in ROK and USA

    Energy Technology Data Exchange (ETDEWEB)

    Tae, Jae Woong; Shin, Dong Hoon [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

    2013-10-15

    Perfect removal of transferred technology is impossible because it is impossible to find all copies of technologies such as files and documents. International community concerns about Terrorists' acquirement of nuclear technologies related to nuclear reactors, enrichment and reprocessing Facilities and heavy water production facilities, which can be used for production of nuclear weapons. Non-state actors as well as concerning countries have tried to possess nuclear technology for developing nuclear weapons. Non-state actors' activities threaten global nuclear security. Korea exported four nuclear power plants to UAE and a research reactor to Jordan. Non-state actors may try to procure nuclear equipment and technology from Korean nuclear industries. Therefore, the export control system should be enhanced for national nuclear security and safety. In this study, the export control system of Korea and the United States were compared concerning to nuclear technology. In summary, controlled activities related to nuclear technology are treated more variously and more diverse activities are controlled in the United States than In Korea. Catch-all control will lose its effectiveness without this. Related to the control of ITT (Intangible Technology Transfer), Korea and the United States are trying to amend the export control regulation. Both of them are trying to control intangible technology transfers effectively. Revised Foreign Trade Act in Korea is expected to introduce a more rigorous system of nuclear technology controls. It focuses on nationality rather than residence. The revised law may face into other problems such as dual nationals like as the United States. However, this satisfies legislative requirements for control of a deemed export. The revised law will enter into force in 2014. Accurate meanings of technology and export will be defined soon in the enforcement decree and the public notice before 2014. However, it is hard to revise the definition

  9. A comparative study on export control systems of nuclear technology in ROK and USA

    International Nuclear Information System (INIS)

    Tae, Jae Woong; Shin, Dong Hoon

    2013-01-01

    Perfect removal of transferred technology is impossible because it is impossible to find all copies of technologies such as files and documents. International community concerns about Terrorists' acquirement of nuclear technologies related to nuclear reactors, enrichment and reprocessing Facilities and heavy water production facilities, which can be used for production of nuclear weapons. Non-state actors as well as concerning countries have tried to possess nuclear technology for developing nuclear weapons. Non-state actors' activities threaten global nuclear security. Korea exported four nuclear power plants to UAE and a research reactor to Jordan. Non-state actors may try to procure nuclear equipment and technology from Korean nuclear industries. Therefore, the export control system should be enhanced for national nuclear security and safety. In this study, the export control system of Korea and the United States were compared concerning to nuclear technology. In summary, controlled activities related to nuclear technology are treated more variously and more diverse activities are controlled in the United States than In Korea. Catch-all control will lose its effectiveness without this. Related to the control of ITT (Intangible Technology Transfer), Korea and the United States are trying to amend the export control regulation. Both of them are trying to control intangible technology transfers effectively. Revised Foreign Trade Act in Korea is expected to introduce a more rigorous system of nuclear technology controls. It focuses on nationality rather than residence. The revised law may face into other problems such as dual nationals like as the United States. However, this satisfies legislative requirements for control of a deemed export. The revised law will enter into force in 2014. Accurate meanings of technology and export will be defined soon in the enforcement decree and the public notice before 2014. However, it is hard to revise the definition of export

  10. IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

    Science.gov (United States)

    Zhou, Hao; Bulek, Katarzyna; Li, Xiao; Herjan, Tomasz; Yu, Minjia; Qian, Wen; Wang, Han; Zhou, Gao; Chen, Xing; Yang, Hui; Hong, Lingzi; Zhao, Junjie; Qin, Luke; Fukuda, Koichi; Flotho, Annette; Gao, Ji; Dongre, Ashok; Carman, Julie A; Kang, Zizhen; Su, Bing; Kern, Timothy S; Smith, Jonathan D; Hamilton, Thomas A; Melchior, Frauke; Fox, Paul L; Li, Xiaoxia

    2017-10-09

    Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood. Here, we report a novel pathway in which LPS/TLR4 engagement promotes nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related mRNAs for translation in murine macrophages. IRAK2 kinase activity is required for LPS-induced RanBP2-mediated IRAK2 sumoylation and subsequent nuclear translocation. Array analysis showed that an SRSF1-binding motif is enriched in mRNAs dependent on IRAK2 for nuclear export. Nuclear IRAK2 phosphorylates SRSF1 to reduce its binding to target mRNAs, which promotes the RNA binding of the nuclear export adaptor ALYREF and nuclear export receptor Nxf1 loading for the export of the mRNAs. In summary, LPS activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation.

  11. Influence of export control policy on the competitiveness of machine tool producing organizations

    Science.gov (United States)

    Ahrstrom, Jeffrey D.

    The possible influence of export control policies on producers of export controlled machine tools is examined in this quantitative study. International market competitiveness theories hold that market controlling policies such as export control regulations may influence an organization's ability to compete (Burris, 2010). Differences in domestic application of export control policy on machine tool exports may impose throttling effects on the competitiveness of participating firms (Freedenberg, 2010). Commodity shipments from Japan, Germany, and the United States to the Russian market will be examined using descriptive statistics; gravity modeling of these specific markets provides a foundation for comparison to actual shipment data; and industry participant responses to a user developed survey will provide additional data for analysis using a Kruskal-Wallis one-way analysis of variance. There is scarce academic research data on the topic of export control effects within the machine tool industry. Research results may be of interest to industry leadership in market participation decisions, advocacy arguments, and strategic planning. Industry advocates and export policy decision makers could find data of interest in supporting positions for or against modifications of export control policies.

  12. Enhanced down regulation of cortical ±-propranolol sensitive [3H]-DHA binding sites by co-administration of DMI and 5-HT1A partial agonist gepirone

    International Nuclear Information System (INIS)

    Geissler, M.A.; Yocca, F.D.

    1990-01-01

    The putative interrelationship between the noradrenergic and serotonergic systems has been supported by numerous studies. Recently, Dudley et al. (1989) demonstrated significant down regulation of cortical β-adrenergic receptors by co-administration of desipramine (DMI), a norepinephrine uptake inhibitor, and the full 5-HT 1A agonist 8-OH-DPAT. To this end, the effects of acute and chronic (4 and 14 day) administration of DMI, gepirone, a selective 5-HT 1A post-synaptic partial agonist, as well as a combination of the two, on cortical (±)-propranolol sensitive [ 3 H]-DHA binding sites were examined in rats. Down regulation was apparent after 4 and 14 day treatment with DMI. However, this was not the case with gepirone. Of particular importance is the demonstration of a greater magnitude of down regulation with co-administration of a greater magnitude of down regulation with co-administration of DMI and gepirone. These results suggests that alteration in rat cortical (±)-propranolol sensitive [ 3 H]-DHA binding sites by noradrenergic uptake inhibitors can be further modulated by selective partial agonist activity at central 5-HT 1A postsynaptic receptors. Further data on the co-administration of DMI and BMY 7378 (7,9-dioxo-8-[2-(4-o-methoxyphenylpiperazinyl)ethyl]-8-azaspiro[4,5]decane dihydrochloride), a weak partial agonist at postsynaptic 5-HT 1A receptors, are also presented

  13. Detecting privatization factors on promoting exports of steel companies

    Directory of Open Access Journals (Sweden)

    Seyed Mohsen SeyedAliAkbar

    2016-05-01

    Full Text Available Privatization is considered as the transfer of business from the government to the private sector. This process is often accomplished in an attempt to reduce the size of government, increase the productivity and export activities. There is no doubt that in an export oriented economy, government tries to promote expert based activities by making necessary changes on rules and regulations. This paper presents an empirical investigation to determine important factors on promoting export in Iran. The study designs a questionnaire in Likert scale and distributes it among some experts active in steel industry. Kaiser-Meyer-Olkin Measure of Sampling Adequacy is equal to 0.839 and Bartlett's Test of Sphericity yields an approximation Chi-Square value of 2485.02 (Sig. = 0.000, df = 276. Using principle component analysis with Varimax rotation, the study has detected five important factors including human resources development, productivity management, marketing management, creating competitive environment and building necessary infrastructures, which influence the most on export activities.

  14. Upgrading the safety assessment of exported nuclear power plants

    International Nuclear Information System (INIS)

    Rosen, M.

    1978-01-01

    An examination of the safety aspects of exported nuclear power plants demonstrates that additional and somewhat special considerations exist for these plants, and thus that some new approaches may be required to insure their safety. In view of the generally small regulatory staffs of importing countries, suggestions are given for measures which should be taken by the various organizations involved in the export and import of nuclear power facilities to raise the level of the very essential safety assessment. These include the upgrading of the 'export edition' of the traditionally supplied safety documentation by use of a Supplementary Information Report, written specifically for the needs of a smaller and/or less technically qualified staff, which highlights the differences that exist between the facility to be constructed and the supposedly similar reference plant of the supplier country; by improvement of supporting safety documentation to allow for adequate understanding of significant safety parameters; and by attention to the needs of smaller countries in the critical Operating Regulations (Technical Specifications for Operation). Consideration is also given to upgrading the regulatory effort and to the obligations of principal organizations involved with exported nuclear plants, including national and international, for insuring the importing countries' technical readiness and the adequacy of the regulatory effort. Special attention is directed towards the project contract as a means of implementing programmes to achieve these goals. (author)

  15. Understanding China's renewable energy technology exports

    International Nuclear Information System (INIS)

    Liu, Jialu; Goldstein, Don

    2013-01-01

    China became a major player in renewable energy (RE) technology during the 2000s. Chinese solar PV cell and module makers quickly dominated global sales in that industry, while the country's wind turbine producers became poised for significant exports after capturing their rapidly growing home market. In countries like the US, Chinese RE technology strength has been met with claims of excessive governmental support of exports. This study examines to what extent Chinese firms' solar PV and wind technology successes have been enabled by policy supports, and whether those policies appear to have been driven by broader goals versus RE export promotion per se. The evidence suggests that governmental policy toward both wind and solar originated in a push for export-competitive Chinese companies. But the specifics differed substantially due to the particular requirements of building technological capabilities in each: export readiness necessitated substantial support for domestic installation of wind but not solar PV power. The findings also suggest that as the decade of the 2000s progressed, environmental goals played an increasing role alongside export promotion in motivating and shaping Chinese RE technology policies. - Highlights: ► Export policy in the rise of Chinese renewable energy technologies is studied. ► Policy supported wind turbine firms' capabilities via domestic uptake, not exports. ► Pre-2009 solar module exports enjoyed, but did not depend on, export subsidies. ► Renewables development also fit wider technology and environmental policy goals.

  16. Through Internal Control System, Jatirogo Organic Coconut Sugar Farmers Gained Access to the Export Market

    OpenAIRE

    Setyowati, Theresia Eko

    2014-01-01

    By founding Jatirogo organic coconut sugar ICS, 1,554 farmer members now have stronger bargaining power in marketing organic coconut sugar. Jatirogo organic coconut sugar ICS has succeeded to export its organic gula semut. By obtaining international certifications (EU Regulation, NOP-USDA, and JAS), KSU Jatirogo sends organic gula semut to various countries, such as the United States, Australia, and European and Asian countries, by collaborating with KSU Jatirogo and exporting companies. ...

  17. Will Exports Prevail over Austerity?

    OpenAIRE

    Vasily Astrov; Vladimir Gligorov; Peter Havlik; Mario Holzner; Gabor Hunya; Kazimierz Laski; Sebastian Leitner; Zdenek Lukas; Anton Mihailov; Olga Pindyuk; Leon Podkaminer; Josef Pöschl; Sandor Richter; Waltraut Urban; Hermine Vidovic

    2010-01-01

    The Central, East and Southeast European (CESEE) economies will experience on average a minor rebound of economic growth to 1% in 2010 which will speed up to 2.5% in 2011 and 3.5% in 2012. GDP growth will be higher in the CIS countries and in Turkey, about average in the Central European NMS and lower in the SEE countries and the Baltics. Growth is currently driven mostly by exports which should outweigh the dampening effects of the austerity measures. Whether the countries will actually bene...

  18. A perspective on energy exports

    International Nuclear Information System (INIS)

    O'Connor, A.J.

    1983-06-01

    Based on New Brunswick Power's energy export experience over the past two decades, it appears that Canada could have a very special and unique opportunity to input into the US energy market over the coming decades. The CANDU reactor can offer one of these opportunities. Such business opportunities can be of very real benefit to both countries and to the particular regions involved. Like any other form of business, this one must be carefully planned and must be conducted in an environment conducive to the achievement of the objectives of the business

  19. Human Capital and Wages in Exporting Firms

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Skaksen, Jan Rose

    2006-01-01

    This paper studies the link between a firms education level, export performance and wages of its workers. We argue that firms may escape intence competition in international markets by using high skilled workers to differentiate their products. This story is consistent with our empirical results....... Osing a very rich matched worker-firm longitudinal dataset we find that firms with high export intensities pay higher wages. However, an interaction term between export intensity and skill intensity has a positive impact on wages and it absorbs the direct effect of the export intensity. That is, we find...... an export wage premium, but it accrues to workers in firms with high skill intensities.Keywords: Exports, Wages, Human Capital, Rent Sharing, Matched Worker-Firm DataJEL Classification: J30, F10, I20...

  20. Promoting exports in the energy technology area

    International Nuclear Information System (INIS)

    Iten, R.; Oettli, B.; Jochem, E.; Mannsbart, W.

    2001-01-01

    This report for the Swiss Federal Office of Energy (SFOE) examines the position of Switzerland as a leader in the investment goods markets for energy-efficiency products and for technologies for using renewable forms of energy. The report quotes figures for exports in these areas and discusses the difficulty of extracting useful data on these products from normal statistical data. Analyses made by a group of experts from the export-oriented technology field, energy service providers and representatives of export promotion institutions are presented and figures are quoted for various product categories. Factors promoting the competitiveness of Swiss products are discussed as well as those impeding it. An analysis of export potential is presented and measures to promote export are discussed. The report also discusses the aids and promotion activities that are considered necessary by companies in the field and the macro-economic perspectives of increased export promotion

  1. Price and Income Elasticities of Russian Exports

    Directory of Open Access Journals (Sweden)

    Bernardina Algieri

    2004-12-01

    Full Text Available The paper gauges export demand elasticities for Russia using an Error Correction technique within a cointegration framework. An extended version of the Imperfect Substitutes Model has been implemented to estimate the sensitivity of Russian exports without oil components to price and to Russian and world income. Our results suggest a robust and negative long run cointegration relationship between the real effective exchange rate, defined as the weighted average of the rouble’s exchange rates versus a basket of the three currencies with the largest share in the trade turnover adjusted to incorporate inflation rate differences (the ratio of the domestic price indices to the foreign price indices, and Russian exports. An increase in exports by 24% is caused by a real depreciation by 10%. Furthermore, a 10% growth in world income leads to a 33% rise in exports. Finally, exports drop by 14% whenever a 10% increase in domestic income occurs

  2. Markups and Firm-Level Export Status

    DEFF Research Database (Denmark)

    De Loecker, Jan; Warzynski, Frederic

    We derive an estimating equation to estimate markups using the insight of Hall (1986) and the control function approach of Olley and Pakes (1996). We rely on our method to explore the relationship between markups and export behavior using plant-level data. We find significantly higher markups when...... we control for unobserved productivity shocks. Furthermore, we find significant higher markups for exporting firms and present new evidence on markup-export status dynamics. More specifically, we find that firms' markups significantly increase (decrease) after entering (exiting) export markets. We...... see these results as a first step in opening up the productivity-export black box, and provide a potential explanation for the big measured productivity premia for firms entering export markets....

  3. Regulations concerning the radionuclides uses in France

    International Nuclear Information System (INIS)

    Vergne, J.

    1955-01-01

    The progress in the uses of radioisotopes has been conditioned by increasing the number of trained workers and researchers and developing theoretical teaching in universities since 1950 in France as well as developing a national control of the distribution and uses of radioisotopes. With the large diffusion and development of radioisotopes uses and applications, new rules and regulations came to control the importation, exportation, transport and utilization of radioisotopes. In the first part, it described the different French laws since 1934 and their successive modifications which ruled on the production, manipulation and utilization of radioisotopes. An inter-ministerial committee was created in 1952 to advise and inform of all the questions related to the preparation, importation, exportation, possession and distribution of radioisotopes. The transport regulations are in constant evolution and has got to meet with international recommendations. It distinguished three different type of transport: road, river and railway transport, postal transport and finally air transport. All the different transports have their specific packaging, maximum transportable quantity, maximum material intensity and labelling requirements. The regulations about customs duties are specified as well as the administrative formalities for non natural radioisotopes importation. Since 1950, diseases caused by irradiation to natural or artificial radioactive materials are recognised as professional diseases and a table of the actual regulations is presented. (M.P.)

  4. 75 FR 10997 - Cuban Assets Control Regulations; Sudanese Sanctions Regulations; Iranian Transactions Regulations

    Science.gov (United States)

    2010-03-10

    ... specific license, or otherwise exempt, the exportation of such services and software from the United States... services and software. Paragraph (c) of each of these two sections provides that specific licenses may be... Iranian Transactions Regulations to authorize the exportation of certain services and software incident to...

  5. Export Failure and its Consequences: Theory and Evidence

    OpenAIRE

    Mora, Jesse

    2015-01-01

    The purpose of this dissertation is to argue that exporting is a risky endeavor and that there are consequences to export failure. Exporters pay high fixed costs to enter foreign markets, yet the majority will not export beyond one year. What happens to these exporters after they fail abroad? For these firms, exporting likely resulted in heavy profit losses. Despite this, trade literature often views exporting as a harmless exercise based on a simple cost-benefit analysis of foreign profits. ...

  6. Export dynamics and sales at home

    OpenAIRE

    Nicolas Berman; Antoine Berthou; Jérôme Héricourt

    2012-01-01

    How do firms’ sales interact across markets? Are foreign and domestic sales complements or substitutes? Using a large French firm-level database that combines balance-sheet and product-destination specific export information over the period 1995-2001, we study the interconnections between exports and domestic sales. We identify exogenous shocks that affect the firms’ demand on foreign markets to instrument yearly variations in exports. We use alternatively as instruments product-destination s...

  7. Uranium enrichment export control guide: Gaseous diffusion

    Energy Technology Data Exchange (ETDEWEB)

    1989-09-01

    This document was prepared to serve as a guide for export control officials in their interpretation, understanding, and implementation of export laws that relate to the Zangger International Trigger List for gaseous diffusion uranium enrichment process components, equipment, and materials. Particular emphasis is focused on items that are especially designed or prepared since export controls are required for these by States that are party to the International Nuclear Nonproliferation Treaty.

  8. Vertical integration, disintegration and ability to export

    OpenAIRE

    Rossini, Giampaolo; Vici, Laura

    2007-01-01

    Recent literature on trade has emphasized the role of firms' heterogeneities in export performance and trade specialization of countries (Melitz, 2003; Melitz and Ottaviano, 2005). Exporting seems to be a strategy available only to most efficient and productive firms even in a framework with transport costs and no reciprocal dumping. We do not know much about the internal organization of these smarter companies which are exporting part of their production. However, from related theoretical (H...

  9. Nuclear exportation and importation - the Brazilian situation

    International Nuclear Information System (INIS)

    Lavos Coimbra, G.

    1986-01-01

    The author proposes to set up a working group which should be responsible for the compilation of laws, procedures, and national policies for the nuclear importation and exportation in the supplying and receiving countries. Shared international views would simplify the flow of imports and exports between the countries. The author describes the different phases of exportation and importation of nuclear material are processed in her country, Brazil. (CW) [de

  10. Import-push or Export-pull?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte

    2014-01-01

    predictions regarding the export market and the role of product differentiation. Empirical results for a sample of Danish manufacturing industries confirm the import- "push" hypothesis as well as the export- "pull" hypothesis, but also reveal differences across industries. The selection effect of trade...... is mainly driven by the "import-push" if product differentiation is high, whereas it is driven by the "export-pull" if goods are homogeneous....

  11. Import-push or Export-pull?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte

    predictions regarding the export market and the role of product differentiation. Empirical results for a sample of Danish manufacturing industries confirm the import-"push" hypothesis as well as the export-"pull" hypothesis, but also reveal differences across industries. The selection effect of trade...... is mainly driven by the "import-push" if product differentiation is high, whereas it is driven by the "export-pull" if goods are homogeneous....

  12. 50 CFR 11.24 - Final administrative action.

    Science.gov (United States)

    2010-10-01

    ... TAKING, POSSESSION, TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND... law judge's decision shall constitute the final administrative determination of the Secretary in the matter and shall become effective 30 calendar days from the date of the decision. ...

  13. 31 CFR 545.406 - Exportation of services; performance of service contracts; legal services.

    Science.gov (United States)

    2010-07-01

    ... of service contracts; legal services. 545.406 Section 545.406 Money and Finance: Treasury Regulations... TALIBAN (AFGHANISTAN) SANCTIONS REGULATIONS Interpretations § 545.406 Exportation of services; performance... received in the territory of Afghanistan controlled by the Taliban. Note to § 545.406. See § 545.513 with...

  14. 15 CFR 30.9 - Transmitting and correcting Electronic Export Information.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Transmitting and correcting Electronic Export Information. 30.9 Section 30.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS General Requirements...

  15. Export opportunities in developing countries

    International Nuclear Information System (INIS)

    Sullivan, J.

    1992-01-01

    Developing countries will offer major opportunities to US exporters of energy and related environmental equipment in the next ten years. These opportunities arise because the markets in developing countries will be growing much faster than those in the developed countries during this period, and because these countries will not in most cases have strong domestic manufacturers to compete against. US technologies will help these countries solve their energy, environmental, and economic development problems, and help the US solve its serious trade balance problems. This market will represent over $200 billion between now and 2000. There are, however, many potential problems. These include a lack of focus and coordination among US government trade assistance organizations, a lack of interest on the part of US firms in exporting and an unwillingness to make the needed investments, barriers put up by the governments of potential foreign customers, and strong international competition. This paper describes how the United States Agency for International Development's (A.I.D.) Office of Energy and other US agencies are helping US firms resolve these problems with a comprehensive program of information, trade promotion assistance, and co-funding of feasibility studies. In addition, there are monies available to match unfair concessionary financing offered by our major competitors

  16. Nuclear exports and international cooperation

    International Nuclear Information System (INIS)

    McCardle, J.J.

    1981-06-01

    Canada's nuclear export policy together with its non-proliferation and safeguards policy embrace both the country's desire to promote international cooperation in the peaceful uses of nuclear energy and its effort to minimize the risk of further proliferation of nuclear weapons. This policy reflects the belief that only if Canadian parliamentary and public opinion can be convinced that Canada's nuclear exports will not contribute to nuclear proliferation will the long-term health of the country's nuclear industry be assured. Canada requires a political commitment to non-proliferation from its nuclear partners, and looks to the IAEA to administer safeguards on nuclear material of Canadian origin to guarantee that commitment. Agreements reached with its nuclear partners are in accordance with provisions of the non-proliferation treaty and include a contingency provision for fall-back safeguards if the other state should withdraw from the NPT. Provision is made for mutual agreement on reprocessing and enrichment of nuclear material. Agreements have been reached with some twenty nuclear partners, and efforts are continuing to come to new international understanding on reprocessing, enrichment, and plutonium storage

  17. The Puzzle of the Missing Greek Exports

    OpenAIRE

    Uwe Boewer; Vasiliki Michou; Christoph Ungerer

    2014-01-01

    Why is Greece such a surprisingly closed economy? We employ a gravity model of trade to explain the appallingly poor export performance of Greece and argue that weak institutional quality accounts for a large part of this shortfall. Using a rich dataset of bilateral value-added exports of goods and services of 39 exporters and 56 importers for 18 sectors, we first estimate that Greece exports ? less than what regular international trade patterns would predict on basis of Greek GDP, the size o...

  18. Health impacts of power-exporting plants in northern Mexico

    International Nuclear Information System (INIS)

    Blackman, Allen; Chandru, Santosh; Mendoza-Domínguez, Alberto; Russell, A.G.

    2012-01-01

    In the past two decades, rapid population and economic growth on the U.S.–Mexico border has spurred a dramatic increase in electricity demand. In response, American energy multinationals have built power plants just south of the border that export most of their electricity to the U.S. This development has stirred considerable controversy because these plants effectively skirt U.S. air pollution regulations in a severely degraded international airshed. Yet to our knowledge, this concern has not been subjected to rigorous scrutiny. This paper uses a suite of air dispersion, health impacts, and valuation models to assess the human health damages in the U.S. and Mexico caused by air emissions from two power-exporting plants in Mexicali, Baja California. We find that these emissions have limited but nontrivial health impacts, mostly by exacerbating particulate pollution in the U.S., and we value these damages at more than half a million dollars per year. These findings demonstrate that power-exporting plants can have cross-border health effects and bolster the case for systematically evaluating their environmental impacts. - Highlights: ► We estimate the health effects of emissions from Mexican electric power plants exporting to the U.S. ► The plants have limited but nontrivial effects, mostly from particulate pollution in the U.S. ► We value these damages at more than half a million dollars per year. ► Hence, power-exporting plants can have significant cross-border health effects.

  19. Norwegian gas export policy - management of external change

    International Nuclear Information System (INIS)

    Claes, Dag Harald.

    1997-01-01

    This report is the first study in the research project '' Norwegian gas policy - external change and national adaptation''. The project is financed through Norges forskningsraad's research program ''Petropol''. The main aim of the project is to understand the market, political and institutional changes in the European gas market as well as what implications they may have for the political and institutional design of the Norwegian gas sector. In this report an approach model is developed for studying the connection between changes in the European gas market and the Norwegian petroleum policy which will be central in several of the later works in the project. The report gives a historic account of Norwegian gas export policy as well, a field where altered frame conditions have given the authorities political and institutional challenges. The main focus in the report is however, connected to the empirical explanation of the connection between changed external environments and alterations in the Norwegian gas export policy. The question the study tries to answer is: To what extent and how the Norwegian gas export policy is affected by alterations in the European gas market and the EU policy towards this market. In the centre of the study of the gas export policy is the element of governmental control. The governmental control assumes ability to formulate national aims as well as the ability to produce laws and regulations which reflects the goals and counts on that the aims are reached in addition to that the authorities either implement the policies themselves or if this is left to other parties, have ability to survey and sanction these parties should they break the guidelines or oppose the national political aims. The report shows how these aspects are affected by changes in the environments surrounding the Norwegian gas export. 6 figs., 1 tab., 45 refs

  20. Foreign Direct Investment and Electronics Exports: Exploratory Empirical Evidence from Malaysia's Top Five Electronics Exports

    OpenAIRE

    Tuck Cheong Tang; Koi Nyen Wong

    2007-01-01

    The foreign direct investment (FDI) has contributed significantly to Malaysia's electronics exports as well as the growth and development of the electronics industry as a result of the export-oriented industrialization initiatives undertaken since 1970s. The aim of this study is to explore the causation between FDI and electronics exports by using Malaysia''s top five electronics exports by SITC (Standard International Trade Classification) product groups. The findings show a bi-directional c...

  1. Export Margins, Price and Quantity of Belarus’s Export Growth

    Directory of Open Access Journals (Sweden)

    Otamurodov Shavkat

    2017-03-01

    Full Text Available This paper examines the sources of Belarus’s export growth and decomposes export growth into extensive and intensive margins. This study also aims to determine export margins for intermediate and final goods and to determine the price and quantity components of the intensive export margin. In order to achieve the desired objectives, we use two methods for decomposing export growth, the count method and the export shares method. We analyse Belarus's export growth using export data at the HS-6 digit level for the 2004-2014 period. Our results show that Belarus's exports grew mainly due to growth in the price margin during the studied period 2004-2014. However, the extensive margin was important in export growth to some extent. Comparing the growth rate across final and intermediate goods reveals that although the share of final products in Belarus’s exports is not very big (18.9% in 2014, the average annual growth in exports of final products is higher than that of intermediate goods. Our investigation also shows that Belarus produces a wide range of commodities, but the share of the most of these commodities is not large; its exports depend on a restricted range of commodities. Moreover, most of the commodities are exported to Russia and Ukraine. Our results give us reason to assume that finding new markets for their new products is one of the main challenges for developing countries wishing to increase their exports by an extensive margin. This has important implications for how policy makers promote the trade and diversification of exports.

  2. 75 FR 70905 - President's Export Council: Meeting of the President's Export Council

    Science.gov (United States)

    2010-11-19

    .... ACTION: Notice of an open meeting. SUMMARY: The President's Export Council will hold a meeting to discuss.... exports, jobs, and growth. DATES: December 9, 2010 at 9 a.m. (EST). ADDRESSES: The President's Export... trade and report to the President on its activities and on its recommendations for expanding U.S...

  3. 76 FR 54193 - Fiscal Year 2012 Veterinary Import/Export, Diagnostic Services, and Export Certification for...

    Science.gov (United States)

    2011-08-31

    ...] Fiscal Year 2012 Veterinary Import/Export, Diagnostic Services, and Export Certification for Plants and.... SUMMARY: This notice pertains to user fees charged for Veterinary Services animal quarantine and other..., organisms, and vectors; for certain veterinary diagnostic services; and for export certification of plants...

  4. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats

    International Nuclear Information System (INIS)

    Pintor, A.; Fortuna, S.; De Angelis, S.; Michalek, H.

    1990-01-01

    Potential age-related differences in the recovery rate of brain cholinesterase activity (ChE) and muscarinic acetylcholine receptor binding sites (mAChRs) following reduction induced by repeated treatment with diisopropyl fluorophosphate (DFP) were evaluated in Sprague-Dawley rats. Male 3- and 24-month old rats were s.c. injected with DFP on alternate days for 2 weeks and killed 48 hr and 7, 14, 21, 28 and 35 days after the last treatment. In the hippocampus and striatum, but not in the cerebral cortex, of control rats there as a significant age-related decline of ChE activity and maximal density of 3H-QNB binding sites (Bmax). The repeated administration of DFP during the first week caused a syndrome of cholinergic stimulation both in aged and young rats. The syndrome was more pronounced, in terms of intensity and duration in aged than in young animals resulting in 40 and 12% mortality, respectively; during the second week the syndrome attenuated in the two age-groups. The percentage inhibition of brain ChE at the end of DFP treatment did not differ between young and surviving aged rats. The down-regulation of mACRs was present in the three brain regions of both young and age rats (from 20 to 40%). Factorial analysis of variance showed significant differences for age, recovery rate, and significant interaction between age and recovery rate, both for ChE and mAChRs in young rats the three brain areas

  5. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats

    Energy Technology Data Exchange (ETDEWEB)

    Pintor, A.; Fortuna, S.; De Angelis, S.; Michalek, H. (Istituto Superiore di Sanita, Rome (Italy))

    1990-01-01

    Potential age-related differences in the recovery rate of brain cholinesterase activity (ChE) and muscarinic acetylcholine receptor binding sites (mAChRs) following reduction induced by repeated treatment with diisopropyl fluorophosphate (DFP) were evaluated in Sprague-Dawley rats. Male 3- and 24-month old rats were s.c. injected with DFP on alternate days for 2 weeks and killed 48 hr and 7, 14, 21, 28 and 35 days after the last treatment. In the hippocampus and striatum, but not in the cerebral cortex, of control rats there as a significant age-related decline of ChE activity and maximal density of 3H-QNB binding sites (Bmax). The repeated administration of DFP during the first week caused a syndrome of cholinergic stimulation both in aged and young rats. The syndrome was more pronounced, in terms of intensity and duration in aged than in young animals resulting in 40 and 12% mortality, respectively; during the second week the syndrome attenuated in the two age-groups. The percentage inhibition of brain ChE at the end of DFP treatment did not differ between young and surviving aged rats. The down-regulation of mACRs was present in the three brain regions of both young and age rats (from 20 to 40%). Factorial analysis of variance showed significant differences for age, recovery rate, and significant interaction between age and recovery rate, both for ChE and mAChRs in young rats the three brain areas.

  6. Scheme to reward microgenerators exporting excess electricity

    International Nuclear Information System (INIS)

    2007-01-01

    Many suppliers are offering tariffs for export. However, many of the tariffs on offer deliver a value that is higher than the underlying commercial value of the electricity to the supplier. In most cases suppliers do not currently register the export within the industry's settlement arrangements and so gain no value from the export they have purchased. It is clear from this that the current situation is unlikely to be sustainable and suppliers will not be able to offer significant payment for a product that has little commercial value to them when the numbers of exporting microgenerators increases. Initiatives to simplify and streamline the existing trading arrangements should be progressed; this should include simplification of processes for registering new export customers and improvements in the provision of new export meters. Suppliers should initiate the change management procedures required to progress Option 1 (allowing suppliers to register a customer's export and import under a single registration (a single MPAN)) through the industry's normal change management procedures. Ofgem should ensure that its review of the Structure of Distribution charges includes the treatment of DUoS charges for customers with microgeneration and ensure that they properly reflect the benefits of microgeneration. Any changes that are progressed should not prevent the subsequent introduction of 'smart meters' that could process both import and export electricity data. Ofgem should ensure that the cost effectiveness of including both an import and export capability in all new metering systems is assessed as part of the metering innovation agenda. Suppliers should make the prices they are offering for export more widely available in a simple and easy to understand form. Government should consider whether additional intervention is required to yield a higher value for exported electricity (or total generation) via mechanisms such as those contemplated under Option 3 (The supplier

  7. Determinants of export demand and their stability in Ghana | Osei ...

    African Journals Online (AJOL)

    Therefore, the study examines the factors that determine export demand in Ghana for the period 1970 to 2011. Using Johansen cointegration methodology, export demand is cointegrated with real effective exchange rate, domestic export prices, world export prices and real world income. The export demand function exhibits ...

  8. 7 CFR 1488.9 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1488.9 Section 1488.9 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Documents Required for Financing § 1488.9 Evidence of export. (a) If the commodity is exported by rail or...

  9. 21 CFR 1312.22 - Application for export permit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Application for export permit. 1312.22 Section... EXPORTATION OF CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.22 Application for export permit. (a) An application for a permit to export controlled substances shall be made on DEA Form 161...

  10. NAICS Sector 92: Public Administration

    Science.gov (United States)

    Find the public administration industries EPA regulations affect, with their North American Industry Classification System (NAICS) code. On those pages you can find a list of laws and regulations that affect your industry as well as compliance information

  11. Determinants Of Vertical And Horizontal Export Diversification ...

    African Journals Online (AJOL)

    The study also reveals domestic investment plays an important role to enhance vertical as well as horizontal export diversification for East Asia, while it only ... resource-based industries and gradually shift production and exports from customary products to more dynamic ones by developing competitive advantage in the ...

  12. Export Specialisation and Local Economic Growth

    NARCIS (Netherlands)

    Naude, Wim; Bosker, Maarten; Matthee, Marianne

    This paper aims to provide empirical evidence on whether export specialization or diversification is better for local economic growth. Using export data from 354 magisterial districts of South Africa for 1996 and 2001 we estimate spatial growth regressions that include measures of the degree of

  13. 14 CFR 1274.942 - Export licenses.

    Science.gov (United States)

    2010-01-01

    ... writing, that the Agreement Officer authorize it to export ITAR-controlled technical data (including... appropriate licenses or other approvals, if required, for exports of hardware, technical data, and software, or for the provision of technical assistance. (b) The Recipient shall be responsible for obtaining...

  14. Potentials in Asian Export Credit Cooperation

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    "Mekong River Regional Development Project advocated by Asian Development Bank (ADB) has been implemented. Trans-Asia Railway and Trans-Asia Highway are being discussed. It is a good opportunity for Asian Export Credit Agencies (ECAs) to cooperate and financing these large crossboarder projects."On May 11, at the 10th Annual Meeting of Asian Export Credit Agencies,

  15. 77 FR 34342 - Order Denying Export Privileges

    Science.gov (United States)

    2012-06-11

    ..., Luohu District, Shenzhen, 518001, China. On January 26, 2011, in the U.S. District Court, District of... Economic Powers Act (50 U.S.C. 1701 et seq. (2000)) (``IEEPA'') and violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2000)) (``AECA''). Specifically, Wu was convicted of illegally exporting...

  16. 77 FR 34340 - Order Denying Export Privileges

    Science.gov (United States)

    2012-06-11

    ... Economic Powers Act (50 U.S.C. 1701 et seq. (2000)) (``IEEPA'') and Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2000)) (``AECA''). Specifically, Chitron- US was convicted of illegally exporting... components designated on the U.S. Munitions List to China through Hong Kong between 2004 and 2007. In...

  17. 78 FR 37785 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-24

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Order Denying Export Privileges In the... Order with the Under Secretary of Commerce for Industry and Security. The appeal must be filed within 45... the Internal Security Act of 1950 (50 U.S.C. 783(b)), or section 38 of the Arms Export Control Act (22...

  18. 27 CFR 28.123 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.123..., or Transportation to a Manufacturing Bonded Warehouse § 28.123 Export marks. (a) General. In addition... filled under the provisions of part 24 of this chapter, the proprietor shall mark the word “Export” on...

  19. 27 CFR 28.103 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.103... Manufacturing Bonded Warehouse § 28.103 Export marks. (a) General. In addition to the marks and brands required... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

  20. Fixed export cost heterogeneity, trade and welfare

    DEFF Research Database (Denmark)

    Jørgensen, Jan Guldager; Schröder, Philipp J.H.

    2008-01-01

    -country intra-industry trade model where firms are of two different marginal costs types and where fixed export costs are heterogeneous across firms. This model traces many of the stylized facts of international trade. However, we find that with heterogeneous fixed export costs there exists a positive bilateral...