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Sample records for experiments vii blazar

  1. Measurement of the blazar Mrk421 flux above 60 GeV with the CELESTE experiment

    International Nuclear Information System (INIS)

    Le Gallou, R.

    2001-11-01

    The CELESTE experiment is based on an ancient solar plant that has been turned into a detector able to detect the particle showers triggered by the interactions of high energy cosmic photons with the earth atmosphere nuclei. The purpose of the CELESTE experiment is to study the emissions of photons by cosmic objects like supernovae remnants, pulsars or active cores of galaxies such as blazars. Blazars are very interesting objects to study because they allow us to investigate matter that is in extreme conditions and to probe a very far past. The aim of this work has been to develop methods for the analysis of the data collected by CELESTE and to validate them. A specific effort has been achieved for the selection of efficient hadronic rejection criteria in order to optimize the sensitivity of the detector. The physics of the detector is detailed from the particle showers to the data analysis. The detector acceptance has been assessed through Monte-Carlo simulations that have been shown that the detection threshold is 30 GeV at the triggering point and 60 GeV after the analysis cuts. The validation tests have been performed on the Crab nebula that is a standard in gamma astronomy for its stability and intensity. CELESTE has been operating since November 1999 in a satisfactory way and has accumulated data on 4 blazars among them Mrk421. Several bursts have been detected on Mrk421 and an average photon flux has been determined. A correlation has been deduced from the activity detected by CELESTE and the activities in the TeV and X ranges which agrees with the simulations

  2. ECRH experiments on the W VII-A stellarator

    International Nuclear Information System (INIS)

    Whilelm, R.; Erckmann, V.; Janzen, G.; Mueller, G.; Schueller, P. G.; Schwoerer, K.; Thumm, H.

    1985-01-01

    Plasma build-up and heating of a ''currentless'' plasma by means of ECR wave irradiation were studied at the Garching W VII-A stellarator. The experiments were performed at 28 GHz with approx. 200 kW RF power and a pulse duration 02 mode corresponding to a 50% O-mode and 50% X-mode mixture) was launched directly into the plasma from the low field side. In a second step the radiation was converted into the almost linearly polarized TE 11 mode and irradiated in O-mode orientation (E-tilde parallel to B-barsub(o), k-bar perpendicular to B-barsub(o)) into the torus, the nonabsorbed part of the RF power was reflected into the plasma in the X-mode by a focussing polarization twist reflector mounted to the inner torus wall. As a main result the heating efficiency has been slightly improved by the transition from ''simple'' to ''advanced'' wave launching (up to 50% instead of approx. 40%). The central electron temperatures were remarkably increased from approx. 700 eV to 1200 eV due to the well localized O-mode absorption of the TE 11 beam, however. The X-mode from the mirror on the other hand does not contribute to the total plasma energy as expected. This is explained by a local absorption of the arising Bernstein waves due to a macroscopically turbulent behaviour of the plasma in the outer regions. Possibly as a result of wave decay into lower hybrid waves pronounced ion tail heating was observed. For both kinds of wave irradiation toroidal plasma currents were generated. This seems to be caused by asimmetrically confined co- and counter-streaming fast electrons

  3. On-Orbit Experiments for Joint Flexibility of ETS-VII Robotic Arm

    Science.gov (United States)

    Kanzawa, Takuya; Matsunaga, Saburo

    In this paper, on-orbit joint flexibility experiments using ETS-VII (Engineering Test Satellite VII) robotic arm are discussed. Considering manipulability of the robotic arm, the arm vibration due to the joint stiffness may influence on the berthing manipulation. The vibration of the robotic arm mounted on a satellite is characterized as follows, 1) coupling between the arm and the satellite attitude vibration, and 2) transition of the arm natural frequency according to its posture changes with the inertial parameter variation. The experiments are planned to evaluate these vibration disturbance. Using telemetry data detected by FTS (Force Torque Sensor) attached to the end-effector, the arm natural frequencies and the transitions of the arm vibration amplitude are analyzed. And the validity of the simulation results is demonstrated.

  4. Blazar Monitoring List

    Data.gov (United States)

    National Aeronautics and Space Administration — This is a compilation of sources in major blazar monitoring programs. This list contains all blazars known to be regularly monitored, plus all the MOJAVE- &...

  5. Blazar Sequence in Fermi Era

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... In this paper, we review the latest research results on the topic of blazar sequence. It seems that the blazar sequence is phenomenally ruled out, while the theoretical blazar sequence still holds. We point out that black hole mass is a dominated parameter accounting for high-power-high-synchrotron-peaked ...

  6. ENDF/B-VII.1 Neutron Cross Section Data Testing with Critical Assembly Benchmarks and Reactor Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Kahler, A.C.; Herman, M.; Kahler,A.C.; MacFarlane,R.E.; Mosteller,R.D.; Kiedrowski,B.C.; Frankle,S.C.; Chadwick,M.B.; McKnight,R.D.; Lell,R.M.; Palmiotti,G.; Hiruta,H.; Herman,M.; Arcilla,R.; Mughabghab,S.F.; Sublet,J.C.; Trkov,A.; Trumbull,T.H.; Dunn,M.

    2011-12-01

    The ENDF/B-VII.1 library is the latest revision to the United States Evaluated Nuclear Data File (ENDF). The ENDF library is currently in its seventh generation, with ENDF/B-VII.0 being released in 2006. This revision expands upon that library, including the addition of new evaluated files (was 393 neutron files previously, now 423 including replacement of elemental vanadium and zinc evaluations with isotopic evaluations) and extension or updating of many existing neutron data files. Complete details are provided in the companion paper [M. B. Chadwick et al., 'ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data,' Nuclear Data Sheets, 112, 2887 (2011)]. This paper focuses on how accurately application libraries may be expected to perform in criticality calculations with these data. Continuous energy cross section libraries, suitable for use with the MCNP Monte Carlo transport code, have been generated and applied to a suite of nearly one thousand critical benchmark assemblies defined in the International Criticality Safety Benchmark Evaluation Project's International Handbook of Evaluated Criticality Safety Benchmark Experiments. This suite covers uranium and plutonium fuel systems in a variety of forms such as metallic, oxide or solution, and under a variety of spectral conditions, including unmoderated (i.e., bare), metal reflected and water or other light element reflected. Assembly eigenvalues that were accurately predicted with ENDF/B-VII.0 cross sections such as unmoderated and uranium reflected {sup 235}U and {sup 239}Pu assemblies, HEU solution systems and LEU oxide lattice systems that mimic commercial PWR configurations continue to be accurately calculated with ENDF/B-VII.1 cross sections, and deficiencies in predicted eigenvalues for assemblies containing selected materials, including titanium, manganese, cadmium and tungsten are greatly reduced. Improvements are also

  7. Core Dominance Parameter for -Ray Loud Blazars

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... In this paper, we compiled 572 blazars that have known core dominance parameter (log ), out of which 121 blazars are -ray loud blazars. We compared log between 121 blazars and the rest with non -ray detections, and found that -ray loud blazars showed a different distribution, and their average ...

  8. Smoothly Varying Bright Blazars

    Science.gov (United States)

    Van Alfen, Nicholas; Hindman, Lauren; Moody, Joseph Ward; Biancardi, Rochelle; Whipple, Parkes; Gaunt, Caleb

    2018-01-01

    It is becoming increasingly apparent that blazar light can vary sinusoidally with periods of hundreds of days to tens of years. Such behavior is expected of, among other things, jets coming from binary black holes. To look for general variability in lesser-known blazars and AGN, in 2015-2016 we monitored 182 objects with Johnson V-band magnitudes reported as being < 16. In all, this campaign generated 22,000 frames from 2,000 unique pointings. We find that approximately one dozen of these objects show evidence of smooth variability consistent with sinusoidal periods. We report on the entire survey sample, highlighting those that show sinusoidal variations.

  9. ENDF/B-VII.1 Neutron Cross Section Data Testing with Critical Assembly Benchmarks and Reactor Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Kahler, A. [Los Alamos National Laboratory (LANL); Macfarlane, R E [Los Alamos National Laboratory (LANL); Mosteller, R D [Los Alamos National Laboratory (LANL); Kiedrowski, B C [Los Alamos National Laboratory (LANL); Frankle, S C [Los Alamos National Laboratory (LANL); Chadwick, M. B. [Los Alamos National Laboratory (LANL); Mcknight, R D [Argonne National Laboratory (ANL); Lell, R M [Argonne National Laboratory (ANL); Palmiotti, G [Idaho National Laboratory (INL); Hiruta, h [Idaho National Laboratory (INL); Herman, Micheal W [Brookhaven National Laboratory (BNL); Arcilla, r [Brookhaven National Laboratory (BNL); Mughabghab, S F [Brookhaven National Laboratory (BNL); Sublet, J C [Culham Science Center, Abington, UK; Trkov, A. [Jozef Stefan Institute, Slovenia; Trumbull, T H [Knolls Atomic Power Laboratory; Dunn, Michael E [ORNL

    2011-01-01

    The ENDF/B-VII.1 library is the latest revision to the United States' Evaluated Nuclear Data File (ENDF). The ENDF library is currently in its seventh generation, with ENDF/B-VII.0 being released in 2006. This revision expands upon that library, including the addition of new evaluated files (was 393 neutron files previously, now 423 including replacement of elemental vanadium and zinc evaluations with isotopic evaluations) and extension or updating of many existing neutron data files. Complete details are provided in the companion paper [1]. This paper focuses on how accurately application libraries may be expected to perform in criticality calculations with these data. Continuous energy cross section libraries, suitable for use with the MCNP Monte Carlo transport code, have been generated and applied to a suite of nearly one thousand critical benchmark assemblies defined in the International Criticality Safety Benchmark Evaluation Project's International Handbook of Evaluated Criticality Safety Benchmark Experiments. This suite covers uranium and plutonium fuel systems in a variety of forms such as metallic, oxide or solution, and under a variety of spectral conditions, including unmoderated (i.e., bare), metal reflected and water or other light element reflected. Assembly eigenvalues that were accurately predicted with ENDF/B-VII.0 cross sections such as unrnoderated and uranium reflected (235)U and (239)Pu assemblies, HEU solution systems and LEU oxide lattice systems that mimic commercial PWR configurations continue to be accurately calculated with ENDF/B-VII.1 cross sections, and deficiencies in predicted eigenvalues for assemblies containing selected materials, including titanium, manganese, cadmium and tungsten are greatly reduced. Improvements are also confirmed for selected actinide reaction rates such as (236)U; (238,242)Pu and (241,243)Am capture in fast systems. Other deficiencies, such as the overprediction of Pu solution system critical

  10. Optical Spectral Variability of Blazars

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... It is well established that blazars show flux variations in the complete electromagnetic (EM) spectrum on all possible time scales ranging from a few tens of minutes to several years. Here, we report the review of optical flux and spectral variability properties of different classes of blazars on IDV and STV ...

  11. Quasi Periodic Oscillations in Blazars

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Home; Journals; Journal of Astrophysics and Astronomy; Volume 35; Issue 3. Quasi Periodic Oscillations in Blazars ... Here we report our recent discoveries of Quasi-Periodic Oscillations (QPOs) in blazars time series data in X-ray and optical electromagnetic bands. Any such detection can give important ...

  12. Blazars with INTEGRAL

    Czech Academy of Sciences Publication Activity Database

    Hudec, René; Blažek, Martin; Kocka, Matúš; Pian, E.

    2009-01-01

    Roč. 18, 3-4 (2009), s. 327-335 ISSN 1392-0049. [INTEGRAL/BART workshop 2009. Karlovy Vary, 26.03.2009-29.03.2009] R&D Project s: GA ČR GA205/08/1207 Grant - others:ESA(XE) ESA-PECS project No. 98023 Institutional research plan: CEZ:AV0Z10030501 Keywords : active galaxies * blazars * gamma rays Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.032, year: 2009

  13. AGN Winds and Blazar Phenomenology

    Science.gov (United States)

    Kazanas, Demos

    2012-01-01

    The launch of {\\em Fermi} produced a significant number of AGN detections to allow statistical treatment of their properties. One of the first such systematics was the "Blazar Divide" in FSRQs and BL Lacs according to their gamma-ray spectral index and luminosity. Further data accumulation indicated this separation to be less clear than thought before. An MHD wind model which can model successfully the Seyfert X-ray absorber properties provides the vestiges of an account of the observed blazar classification. We propose to employ this model to model in detail the broad band blazar spectra and their statistical properties in terms of the physical parameters of these MHD winds.

  14. Multi-Waveband Emission Maps of Blazars

    Indian Academy of Sciences (India)

    2016-01-27

    ray bright blazars designed to locate the emission regions of blazars from radio to -ray frequencies. The `maps' are anchored by sequences of images in both total and polarized intensity obtained with the VLBA at an angular ...

  15. Blazar Sequence in Fermi Era Liang Chen

    Indian Academy of Sciences (India)

    Abstract. In this paper, we review the latest research results on the topic of blazar sequence. It seems that the blazar sequence is phenomenally ruled out, while the theoretical blazar sequence still holds. We point out that black hole mass is a dominated parameter accounting for high-power- high-synchrotron-peaked and ...

  16. Blazar Sequence in Fermi Era Liang Chen

    Indian Academy of Sciences (India)

    HSP) blazars indicates that this simple analysis should be problematic. So does the discovery of numerous low-power-low-sychrotron-peaked (LP-LSP) blazars. If a blazar has a less beaming jet, its synchrotron bump should peak at lower fre- quency and lower power. Therefore, beaming effect may account for HP-HSP and.

  17. Gamma-Ray and Multiwavelength Emission from Blazars Meg Urry

    Indian Academy of Sciences (India)

    Abstract. Blazars are now well understood as approaching relativistic jets aligned with the line of sight. The long-time uncertainty about the demographics of blazars is starting to become clearer: since the Fermi blazar sample includes a larger fraction of high-frequency peaked blazars. (like the typical X-ray-selected blazars ...

  18. SMORN VII. V.1

    International Nuclear Information System (INIS)

    1996-01-01

    These proceedings of the first volume (1 of 2) of the Smorn VII symposium on nuclear reactor surveillance and diagnostics are divided into 7 sessions bearing on: 1) Nuclear power plant surveillance: feedback experience (10 papers); 2) BWR stability monitoring (5 papers); 3) Signal processing advances and applications (11 papers); 4) Neural networks: utilization for monitoring (11 papers); 5) Leak detection in primary systems (6 papers); 6) Thermohydraulics measurements and boiling detection (10 papers); 7) System feedback experience and new system development (8 papers)

  19. Frequency dependent polarization in blazars

    International Nuclear Information System (INIS)

    Bjoernsson, C.I.

    1984-10-01

    It is argued that the intrinsic frequency dependent polarization in blazars finds its most straightforward explanations in terms of a single rather than a multicomponent sourcemodel. In order to reproduce the observations, under the assumption that the emission mechanism is optically thin synchrotron radiation, both a well ordered magnetic field and an electron distribution with a sharp break or cuttoff are necessary. Non-uniform pitch angle distribution and/or environments where synchrotron losses are important are both conducive to producing strong frequency dependent polarization. Reasons are put forth as to why such conditions ar expected to occur in blazars. Two specific models are discussed in detail and it is shown that they are both able to produce strong frequency dependent polarization, even when the spectral index changes by a small amount only. (orig.)

  20. Estimating Black Hole Masses of Blazars

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Estimating black hole masses of blazars is still a big challenge. Because of the contamination of jets, using the previously suggested size–continuum luminosity relation can overestimate the broad line region (BLR) size and black hole mass for radio-loud AGNs, including blazars. We propose a new relation ...

  1. Multiwavelength Emission from Blazars – Conference Summary ...

    Indian Academy of Sciences (India)

    Abstract. Presentations at the Guangzhou Conference on Multiwave- length Emission from Blazars confirmed our understanding of blazars as relativistic jets closely aligned with the line of sight. Powerful new studies have been enabled by the Fermi gamma-ray satellite and new ground- based TeV facilities, which are an ...

  2. Automated Blazar Light Curves Using Machine Learning

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Spencer James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-27

    This presentation describes a problem and methodology pertaining to automated blazar light curves. Namely, optical variability patterns for blazars require the construction of light curves and in order to generate the light curves, data must be filtered before processing to ensure quality.

  3. Core shift effect in blazars

    Science.gov (United States)

    Agarwal, A.; Mohan, P.; Gupta, Alok C.; Mangalam, A.; Volvach, A. E.; Aller, M. F.; Aller, H. D.; Gu, M. F.; Lähteenmäki, A.; Tornikoski, M.; Volvach, L. N.

    2017-07-01

    We studied the pc-scale core shift effect using radio light curves for three blazars, S5 0716+714, 3C 279 and BL Lacertae, which were monitored at five frequencies (ν) between 4.8 and 36.8 GHz using the University of Michigan Radio Astronomical Observatory (UMRAO), the Crimean Astrophysical Observatory (CrAO) and Metsähovi Radio Observatory for over 40 yr. Flares were Gaussian fitted to derive time delays between observed frequencies for each flare (Δt), peak amplitude (A) and their half width. Using A ∝ να, we infer α in the range of -16.67-2.41 and using Δ t ∝ ν ^{1/k_r}, we infer kr ∼ 1, employed in the context of equipartition between magnetic and kinetic energy density for parameter estimation. From the estimated core position offset (Ωrν) and the core radius (rcore), we infer that opacity model may not be valid in all cases. The mean magnetic field strengths at 1 pc (B1) and at the core (Bcore) are in agreement with previous estimates. We apply the magnetically arrested disc model to estimate black hole spins in the range of 0.15-0.9 for these blazars, indicating that the model is consistent with expected accretion mode in such sources. The power-law-shaped power spectral density has slopes -1.3 to -2.3 and is interpreted in terms of multiple shocks or magnetic instabilities.

  4. Homosexuals and Title VII

    Science.gov (United States)

    Rivera, Juan R.; Galvan, Richard J.

    1975-01-01

    A method of dealing with the problems of discrimination against homosexuals in private employment through the application of Title VII of the Civil Rights Act of 1964 is discussed. The scope of the paper is limited to male homosexuals. (LBH)

  5. Gravitational microlensing of gamma-ray blazars

    DEFF Research Database (Denmark)

    F. Torres, Diego; E. Romero, Gustavo; F. Eiroa, Ernesto

    2003-01-01

    We present a detailed study of the effects of gravitational microlensing on compact and distant $\\gamma$-ray blazars. These objects have $\\gamma$-ray emitting regions which are small enough as to be affected by microlensing effects produced by stars lying in intermediate galaxies. We analyze...... galactic latitude whose gamma-ray statistical properties are very similar to detected $\\gamma$-ray blazars) are indeed the result of gravitational lensing magnification of background undetected Active Galactic Nuclei (AGNs)....

  6. Core Dominance Parameter for γ-Ray Loud Blazars SH Li, JH Fan ...

    Indian Academy of Sciences (India)

    Abstract. In this paper, we compiled 572 blazars that have known core dominance parameter (log R), out of which 121 blazars are γ-ray loud blazars. We compared log R between 121 blazars and the rest with non γ-ray detections, and found that γ-ray loud blazars showed a diffe- rent distribution, and their average value of ...

  7. Recombinant-activated factor VII in the paediatric cardiac surgery ...

    African Journals Online (AJOL)

    Recombinant-activated factor VII in the paediatric cardiac surgery: Single unit experience. V Agarwal, KE Okonta, PS Lal. Abstract. Background: The control of excessive bleeding after paediatric cardiac surgery can be challenging. This may make the use of recombinant-activated factor VII (rFVIIa) in preventing this ...

  8. Optical spectroscopic observations of blazars and γ-ray blazar candidates in the sloan digital sky survey data release nine

    Energy Technology Data Exchange (ETDEWEB)

    Massaro, F.; Masetti, N.; D' Abrusco, R.; Paggi, A.; Funk, S.

    2014-09-09

    We present an analysis of the optical spectra available in the Sloan Digital Sky Survey data release nine (SDSS DR9) for the blazars listed in the ROMA-BZCAT and for the γ-ray blazar candidates selected according to their IR colors. First, we adopt a statistical approach based on Monte Carlo simulations to find the optical counterparts of the blazars listed in the ROMA-BZCAT catalog. Then, we crossmatched the SDSS spectroscopic catalog with our selected samples of blazars and γ-ray blazar candidates, searching for those with optical spectra available to classify our blazar-like sources and, whenever possible, to confirm their redshifts. Our main objectives are to determine the classification of uncertain blazars listed in the ROMA-BZCAT and to discover new gamma-ray blazars. For the ROMA-BZCAT sources, we investigated a sample of 84 blazars, confirming the classification for 20 of them and obtaining 18 new redshift estimates. For the γ-ray blazars, indicated as potential counterparts of unassociated Fermi sources or with uncertain nature, we established the blazar-like nature of 8 out of the 27 sources analyzed and confirmed 14 classifications.

  9. Consequences of Proton Acceleration in Blazar Jets

    Directory of Open Access Journals (Sweden)

    Apostolos Mastichiadis

    2016-11-01

    Full Text Available Hadronic models of blazar emission constitute an interesting alternative to the more popular leptonic ones. Using the BL Lac object Mrk 421 as a characteristic example, we present two distinct ways of modeling the spectral energy distribution of blazars in the hadronic context, and we discuss the predictions of each variant on the spectral shape, the multi-wavelength variability, the cosmic-ray flux, and the high-energy neutrino emission. Focusing on the latter, we then present an application of the hadronic model to individual BL Lacs that were recently suggested to be the counterparts of some of the IceCube neutrinos.

  10. Astronomical Plate Archives and Binary Blazars Studies

    Czech Academy of Sciences Publication Activity Database

    Hudec, René

    2011-01-01

    Roč. 32, 1-2 (2011), s. 91-95 ISSN 0250-6335. [Conference on Multiwavelength Variability of Blazars. Guangzhou, 22,09,2010-24,09,2010] R&D Projects: GA ČR GA205/08/1207 Grant - others:GA ČR(CZ) GA102/09/0997; MŠMT(CZ) ME09027 Institutional research plan: CEZ:AV0Z10030501 Keywords : astronomical plates * plate archives archives * binary blazars Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.400, year: 2011

  11. Radio Band Observations of Blazar Variability

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... The properties of blazar variability in the radio band are studied using the unique combination of temporal resolution from single dish monitoring and spatial resolution from VLBA imaging. Such measurements now available in all four Stokes parameters, together with theoretical simulations, identify the ...

  12. The Blazar Sequence 2.0

    Directory of Open Access Journals (Sweden)

    Gabriele Ghisellini

    2016-09-01

    Full Text Available This paper discusses the spectral energy distribution (SED of all blazars with redshift detected by the Fermi satellite and listed in the 3LAC catalog. The so called “blazar sequence” from the phenomenological point of view will be updated, with no theory or modelling. It will be shown that: (i pure data show that jet and accretion power are related; (ii the updated blazar sequence maintains the properties of the old version, albeit with a less pronounced dominance of the γ-ray emission; (iii at low bolometric luminosities, two different types of objects have the same high energy power: low black hole mass flat spectrum radio quasars and high mass BL Lacs. Therefore, at low luminosities, there is a very large dispersion of SED shapes; (iv in low power BL Lacs, the contribution of the host galaxy is important. Remarkably, the luminosity distribution of the host galaxies of BL Lacs are spread in a very narrow range; (v a simple sum of two smoothly joining power laws can describe the blazar SEDs very well.

  13. Polarization Observations of the Fermi blazars

    Science.gov (United States)

    Rani, Bindu; S. Jorstad, A. P. Marscher (BU, USA), K. Sokolovsky (IAASARS, Greece), I. Agudo (CSIC, Spain)

    2018-01-01

    Ever since the revolutionary discovery by the Fermi mission that active galactic nuclei (AGN) produce copious amounts of high-energy emission, its origin has remained elusive. Using high-frequency radio interferometry (VLBI) polarization imaging, we could probe the magnetic field topology of the compact high-energy emission regions in blazars. A case study for blazar 3C 279 reveals presence of multiple gamma-ray emission regions. The observed anti-correlation between gamma-ray flux and percentage polarization at optical bands challenges the current high-energy emission models. In addition to the turbulent component responsible for gamma-ray flares, our analysis suggests the presence of a steady polarized component having with its polarization direction aligned along the jet axis. The steady polarized component could possibly be the toroidal component of the helical magnetic field. To better understand the acceleration processes in jets, high-energy polarization missions are of great importance.

  14. BLAZAR FLARES FROM COMPTON DRAGGED SHELLS

    Energy Technology Data Exchange (ETDEWEB)

    Golan, Omri; Levinson, Amir, E-mail: Levinson@wise.tau.ac.il [School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978 (Israel)

    2015-08-10

    We compute the dynamics and emission of dissipative shells that are subject to a strong Compton drag, under simplifying assumptions about the dissipation mechanism. We show that under conditions prevailing in blazars, substantial deceleration is anticipated on sub-parsec and parsec scales in cases of rapid dissipation. Such episodes may be the origin of some of the flaring activity occasionally observed in gamma-ray blazars. The shape of the light curves thereby produced reflects the geometry of the emitting surface if the deceleration is very rapid, or the dynamics of the shell if the deceleration is delayed, or initially more gradual, owing, e.g., to continuous injection of energy and momentum.

  15. Search for neutrinos from flaring blazars

    Energy Technology Data Exchange (ETDEWEB)

    Kreter, Michael [Lehrstuhl fuer Astronomie, Universitaet Wuerzburg, Emil-Fischer-Strasse 31, 97074 Wuerzburg (Germany); ECAP, Universitaet Erlangen-Nuernberg, Erwin-Rommel-Str. 1, 91058 Erlangen (Germany); Eberl, Thomas; James, Clancy [ECAP, Universitaet Erlangen-Nuernberg, Erwin-Rommel-Str. 1, 91058 Erlangen (Germany); Kadler, Matthias [Lehrstuhl fuer Astronomie, Universitaet Wuerzburg, Emil-Fischer-Strasse 31, 97074 Wuerzburg (Germany); Collaboration: ANTARES-KM3NeT-Erlangen-Collaboration

    2016-07-01

    Jets from Active Galactic Nuclei (AGN) are among the best candidates for the recently detected extraterrestrial neutrino flux. Hadronic AGN jet-emission models predict a tight correlation between the neutrino flux and the time-variable gamma-ray emission. At the same time, the atmospheric-background (noise) signal, which often dominates in neutrino-astronomical observations, can be substantially reduced by rejecting long-lasting periods of low flux. For these reasons, short high-amplitude gamma-ray flares, as often observed in blazars, can be used to substantially increase the sensitivity of neutrino telescopes in point-source searches. We develop a strategy to search for TeV neutrinos from flaring blazar jets from the TANAMI sample using the ANTARES telescope and Fermi gamma-ray light curves. An unbinned maximum-likelihood method is applied to optimize the probability of a neutrino detection from TANAMI sources.

  16. Investigation of blazars with the INTEGRAL satellite

    Czech Academy of Sciences Publication Activity Database

    Hudec, René; Kubánek, K.; Münz, Filip; Pian, E.

    2007-01-01

    Roč. 166, - (2007), s. 255-257 ISSN 0920-5632. [International Conference on Particle and Fundamental Physics in Space /3./. Beijing, 19.04.2007-21.04.2007] Grant - others:EU(XE) ESA-PECS project No. 98023 Institutional research plan: CEZ:AV0Z10030501 Source of funding: V - iné verejné zdroje Keywords : blazars * gamma-rays Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 0.875, year: 2005

  17. Ringo2 Optical Polarimetry of Blazars

    Directory of Open Access Journals (Sweden)

    Helen Jermak

    2016-10-01

    Full Text Available We present polarimetric and photometric observations from a sample of 15 γ-ray bright blazars with data from the Tuorla blazar monitoring program (KVA DIPOL and Liverpool Telescope (LT Ringo2 polarimeters (supplemented with γ-ray data from Fermi-LAT. We find that (1 The optical magnitude and γ-ray flux are positively correlated; (2 electric vector position angle rotations can occur in any blazar subclass; (3 there is no difference in the γ-ray flaring rates in the sample between subclasses; flares can occur during and outside of rotations with no preference for this behaviour; (4 the average degree of polarisation (P, optical magnitude and γ-ray flux are lower during a rotation compared with during non-rotation; (5 the number of observed flaring events and optical polarisation rotations are correlated and (6 the maximum observed P increases from ∼10% to ∼30% to ∼40% for subclasses with synchrotron peaks at high, intermediate and low frequencies respectively.

  18. Multi-Band Spectral Properties of Fermi Blazars Benzhong Dai ...

    Indian Academy of Sciences (India)

    ... FSRQs, 41 AGNs of other types and 72 AGNs of unknown type (Abdo et al. 2010a). This large sample enable us to investigate the spectral shapes of blazars from optical to X-ray to γ-ray in more detail than has been done before. For this purpose, we collected data for all Fermi blazars having available spectral information.

  19. Astronomical Plate Archives and Binary Blazars Studies Rene Hudec

    Indian Academy of Sciences (India)

    data mining and data analyses by powerful computers with these archives. Examples of blazars proposed and/or investigated on the astronomical plates are presented and discussed. Key words. Astronomical plates—astronomical archives—binary blazars. 1. Introduction. The study of long-term activity of astrophysical ...

  20. The Effect of Blazar Spectral Breaks on the Blazar Contribution to the Extragalactic Gamma-Ray Background

    Science.gov (United States)

    Venters, Tonia M.; Pavlidou, Vasiliki

    2011-01-01

    The spectral shapes of the contributions of different classes of unresolved gamma-ray emitters can provide insight into their relative contributions to the extragalactic gamma-ray background (EGB) and the natures of their spectra at GeV energies, We calculate the spectral shapes of the contributions to the EGB arising from BL Lacertae type objects (BL Lacs) and flat-spectrum radio quasars (FSRQs) assuming blazar spectra can be described as broken power laws, We fit the resulting total blazar spectral shape to the Fermi Large Area Telescope measurements of the EGB, finding that the best-fit shape reproduces well the shape of the Fermi EGB for various break scenarios. We conclude that a scenario in which the contribution of blazars is dominant cannot be excluded on spectral grounds alone, even if spectral breaks are shown to be common among Fermi blazars. We also find that while the observation of a featureless (within uncertainties) power-law EGB spectrum by Fermi does not necessarily imply a single class of contributing unresolved sources with featureless individual spectra, such an observation and the collective spectra of the separate contributing populations determine the ratios of their contributions. As such, a comparison with studies including blazar gamma-ray luminosity functions could have profound implications for the blazar contribution to the EGB, blazar evolution, and blazar gamma-ray spectra and emission.

  1. Comparative sensitivity study of some criticality safety benchmark experiments using JEFF-3.1.2, JEFF-3.2T and ENDF/B-VII.1

    International Nuclear Information System (INIS)

    Kooyman, Timothee; Messaoudia, Nadia

    2014-01-01

    A sensitivity study on a set of evaluated criticality benchmarks with two versions of the JEFF nuclear data library, namely JEFF-3.1.2 and JEFF-3.2T, and ENDF/B-VII.1 was performed using MNCP(X) 2.6.0. As these benchmarks serve to estimate the upper safety limit for criticality risk analysis at SCK.CEN the sensitivity of their results to nuclear data is an important parameter to asses. Several nuclides were identified as being responsible for an evident change in the effective multiplication factor k eff : 235 U, 239 Pu, 240 Pu, 54 Fe, 56 Fe, 57 Fe and 208 Pb. A high sensitivity was found to the fission cross-section of all the fissile material in the study. Additionally, a smaller sensitivity to inelastic and capture cross-section of 235 U and 240 Pu was also found. Sensitivity to the scattering law for non-fissile material was postulated. The biggest change in the k eff due to non-fissile material was due to 208 Pb evaluation (±700 pcm), followed by 56 Fe (±360 pcm) for both versions of the JEFF library. Changes due to 235 U (±300 pcm) and Pu isotopes (±120 pcm for 239 Pu and ±80 pcm for 240 Pu) were found only with JEFF-3.1.2. 238 U was found to have no effect on the k eff . Significant improvements were identified between the two versions of the JEFF library. No further differences were found between the JEFF-3.2T and the ENDF/B-VII.1 calculations involving 235 U or Pu. (authors)

  2. General Physical Properties of CGRaBS Blazars

    Science.gov (United States)

    Paliya, Vaidehi S.; Marcotulli, L.; Ajello, M.; Joshi, M.; Sahayanathan, S.; Rao, A. R.; Hartmann, D.

    2017-12-01

    We present the results of a multi-frequency, time-averaged analysis of blazars included in the Candidate Gamma-ray Blazar Survey catalog. Our sample consists of 324 γ-ray detected (γ-ray loud) and 191 γ-ray undetected (γ-ray quiet) blazars; we consider all the data up to 2016 April 1. We find that both the γ-ray loud and γ-ray quiet blazar populations occupy similar regions in the WISE color-color diagram, and γ-ray loud sources are brighter in the radio and X-ray bands. A simple one-zone synchrotron inverse-Compton emission model is applied to derive the physical properties of both populations. We find that the central black hole mass and accretion disk luminosity ({L}{disk}) computed from the modeling of the optical-UV emission with a Shakura-Sunyaev disk reasonably matches that estimated from the optical spectroscopic emission-line information. A significantly larger Doppler boosting in the γ-ray loud blazars is noted, and their jets are more radiatively efficient. On the other hand, the γ-ray quiet objects are more MeV-peaked and thus could be potential targets for next-generation MeV missions. Our results confirm earlier findings about the accretion-jet connection in blazars; however, many of the γ-ray quiet blazars tend to deviate from the recent claim that the jet power exceeds {L}{disk} in blazars. A broadband study, considering a larger set of γ-ray quiet objects and also including BL Lacs, will be needed to confirm/reject this hypothesis as well as to verify the evolution of the powerful high-redshift blazars into their low-power nearby counterparts.

  3. THE WISE BLAZAR-LIKE RADIO-LOUD SOURCES: AN ALL-SKY CATALOG OF CANDIDATE γ-RAY BLAZARS

    International Nuclear Information System (INIS)

    D'Abrusco, R.; Paggi, A.; Smith, H. A.; Massaro, F.; Masetti, N.; Landoni, M.; Tosti, G.

    2014-01-01

    We present a catalog of radio-loud candidate γ-ray emitting blazars with WISE mid-infrared colors similar to the colors of confirmed γ-ray blazars. The catalog is assembled from WISE sources detected in all four WISE filters, with colors compatible with the three-dimensional locus of the WISE γ-ray emitting blazars, and which can be spatially cross-matched with radio sources from one of the three radio surveys: NVSS, FIRST, and/or SUMSS. Our initial WISE selection uses a slightly modified version of previously successful algorithms. We then select only the radio-loud sources using a measure of the radio-to-IR flux, the q 22 parameter, which is analogous to the q 24 parameter known in the literature but which instead uses the WISE band-four flux at 22 μm. Our final catalog contains 7855 sources classified as BL Lacs, FSRQs, or mixed candidate blazars; 1295 of these sources can be spatially re-associated as confirmed blazars. We describe the properties of the final catalog of WISE blazar-like radio-loud sources and consider possible contaminants. Finally, we discuss why this large catalog of candidate γ-ray emitting blazars represents a new and useful resource to address the problem of finding low-energy counterparts to currently unidentified high-energy sources

  4. Extended radio emission and the nature of blazars

    International Nuclear Information System (INIS)

    Antonucci, R.R.J.; Ulvestad, J.S.

    1985-01-01

    The VLA has been used at 20 cm to map all 23 of the 54 confirmed blazars listed in the Angel and Stockman review paper that had not been mapped before at high resolution. (Blazars include BL Lac objects and optically violently variable quasars.) In addition, data on most of the previously mapped blazars have been reprocessed in order to achieve higher dynamic range. Extended emission has been detected associated with 49 of the 54 objects. The extended radio emission has been used to test the hypothesis that blazars are normal radio galaxies and radio quasars viewed along the jet axes. We find that blazars have substantial extended power, consistent with this hypothesis. Many have extended powers as high as the luminous Fanaroff-Riley class 2 radio doubles. The projected linear sizes are small, as expected from foreshortening of the extended sources, and many blazars have the expected core-halo morphology. There are also several small doubles, a head-tail source, and some one-sided sources, and these could be in cases where the line of sight is slightly off the jet axis, or projections of asymmetrical radio galaxies and quasars. The ratio of core to extended radio emission has been studied as a possible indicator of viewing aspect or beaming intensity. It is found to correlate with optical polarization, optical and radio core variability, and one-sided radio morphology. We can go beyond these consistency checks and work toward a proof of the hypothesis under discussion. The flux from the extended emission alone is sufficient in some blazars to qualify them for inclusion in the 3C and 4C catalogs. Suppose that the radio core emission is anisotropic, but the extended emission is predominantly isotropic. The isotropy of the extended emission implies that these blazars would be in the catalogs even if viewed from the side

  5. Genetics Home Reference: factor VII deficiency

    Science.gov (United States)

    ... VII deficiency , is caused by mutations in the F7 gene, which provides instructions for making a protein ... about the gene associated with factor VII deficiency F7 Related Information What is a gene? What is ...

  6. BROADBAND OBSERVATIONS OF HIGH REDSHIFT BLAZARS

    Energy Technology Data Exchange (ETDEWEB)

    Paliya, Vaidehi S. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Parker, M. L.; Fabian, A. C. [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom); Stalin, C. S., E-mail: vpaliya@g.clemson.edu [Indian Institute of Astrophysics, Block II, Koramangala, Bangalore-560034 (India)

    2016-07-01

    We present a multi-wavelength study of four high redshift blazars, S5 0014+81 ( z = 3.37), CGRaBS J0225+1846 ( z = 2.69), BZQ J1430+4205 ( z = 4.72), and 3FGL J1656.2−3303 ( z = 2.40) using quasi-simultaneous data from the Swift , Nuclear Spectroscopic Telescope Array ( NuSTAR ) and the Fermi -Large Area Telescope (LAT) and also archival XMM-Newton observations. Other than 3FGL J1656.2−3303, none of the sources were known as γ -ray emitters, and our analysis of ∼7.5 yr of LAT data reveals the first time detection of statistically significant γ -ray emission from CGRaBS J0225+1846. We generate the broadband spectral energy distributions (SED) of all the objects, centering at the epoch of NuSTAR observations and reproduce them using a one-zone leptonic emission model. The optical−UV emission in all the objects can be explained by radiation from the accretion disk, whereas the X-ray to γ -ray windows of the SEDs are found to be dominated by inverse Compton scattering off the broad line region photons. All of them host black holes that are billions of solar masses. Comparing the accretion disk luminosity and the jet power of these sources with a large sample of blazars, we find them to occupy a high disk luminosity–jet power regime. We also investigate the X-ray spectral properties of the sources in detail with a major focus on studying the causes of soft X-ray deficit, a feature generally seen in high redshift radio-loud quasars. We summarize that this feature could be explained based on the intrinsic curvature in the jet emission rather than being due to the external effects predicted in earlier studies, such as host galaxy and/or warm absorption.

  7. The Gamma-Ray Blazar Content of the Northern Sky

    Energy Technology Data Exchange (ETDEWEB)

    Michelson, Peter

    2003-07-16

    Using survey data, we have re-evaluated the correlation of flat spectrum radio sources with EGRET sources in the Northern sky. An analysis incorporating the radio and X-ray properties and the {gamma}-ray source localization is used to gauge the reliability of associations and to search for counterparts of previously unidentified EGRET sources. Above |b|=10{sup o}, where the classification is complete, we find that 70% of the Northern EGRET sources have counterparts similar to the bright EGRET blazars. For several of these we identify known blazar counterparts more likely than the earlier proposed 3EG association; for {approx}20 we have new identifications. Spectroscopic confirmation of these candidates is in progress and we have found flat spectrum radio quasars and BL Lac counterparts with redshifts as high as 4. We also find strong evidence for a set of 28 objects with no plausible counterpart like the known EGRET blazars. These thus represent either a new extragalactic population or a population of Galactic objects with a large scale height. The survey has been extended into the plane, where we find several new blazar candidates; the bulk of the sources are, however, Galactic. Looking ahead to the GLAST era, we predict that several of the present 3EG sources are composite and that higher resolution data will break these into multiple blazar IDs.

  8. Positivity VII (Zaanen Centennial Conference)

    CERN Document Server

    Pagter, Ben; Gaans, Onno; Veraar, Mark

    2016-01-01

    This book presents the proceedings of Positivity VII, held from 22-26 July 2013, in Leiden, the Netherlands. Positivity is the mathematical field concerned with ordered structures and their applications in the broadest sense of the word. A biyearly series of conferences is devoted to presenting the latest developments in this lively and growing discipline. The lectures at the conference covered a broad spectrum of topics, ranging from order-theoretic approaches to stochastic processes, positive solutions of evolution equations and positive operators on vector lattices, to order structures in the context of algebras of operators on Hilbert spaces. The contributions in the book reflect this variety and appeal to university researchers in functional analysis, operator theory, measure and integration theory and operator algebras. Positivity VII was also the Zaanen Centennial Conference to mark the 100th birth year of Adriaan Cornelis Zaanen, who held the chair of Analysis in Leiden for more than 25 years and was ...

  9. Congenital deficiency of factor VII.

    Science.gov (United States)

    Sikka, M; Gomber, S; Madan, N; Rusia, U; Sharma, S

    1996-01-01

    A case of congenital factor VII deficiency in a five-year-old child is reported. The patient, born of a non-consanguineous marriage, presented with repeated bouts of epistaxis since childhood. The prothrombin time (PT) was markedly prolonged with a normal bleeding time (BT), partial thromboplastin time with Kaolin (PTTK) and platelet count. The patient has been on follow up for the last four years and is doing apparently well.

  10. Highlights of Spanish Astrophysics VII

    Science.gov (United States)

    Guirado, J. C.; Lara, L. M.; Quilis, V.; Gorgas, J.

    2013-05-01

    "Highlights of Astronomy and Astrophysics VII" contains the Proceedings of the biannual meeting of the Spanish Astronomical Society held in Valencia from July 9 to 13, 2012. Over 300 astronomer, both national and international researchers, attended to the conference covering a wide variety of astrophysical topics: Galaxies and Cosmology, The Milky Way and Its Components, Planetary Sciences, Solar Physics, Instrumentation and Computation, and Teaching and Outreach of Astronomy.

  11. HIGH-ENERGY NEUTRINOS FROM RECENT BLAZAR FLARES

    Energy Technology Data Exchange (ETDEWEB)

    Halzen, Francis; Kheirandish, Ali [Wisconsin IceCube Particle Astrophysics Center and Department of Physics, University of Wisconsin, Madison, WI 53706 (United States)

    2016-11-01

    The energy density of cosmic neutrinos measured by IceCube matches the one observed by Fermi in extragalactic photons that predominantly originate in blazars. This has inspired attempts to match Fermi sources with IceCube neutrinos. A spatial association combined with a coincidence in time with a flaring source may represent a smoking gun for the origin of the IceCube flux. In 2015 June, the Fermi Large Area Telescope observed an intense flare from blazar 3C 279 that exceeded the steady flux of the source by a factor of 40 for the duration of a day. We show that IceCube is likely to observe neutrinos, if indeed hadronic in origin, in data that are still blinded at this time. We also discuss other opportunities for coincident observations that include a recent flare from blazar 1ES 1959+650 that previously produced an intriguing coincidence with AMANDA observations.

  12. Intrinsic brightness temperatures of blazar jets at 15 GHz

    Directory of Open Access Journals (Sweden)

    Hovatta Talvikki

    2013-12-01

    Full Text Available We have developed a new Bayesian Markov Chain Monte Carlo method to deconvolve light curves of blazars into individual flares, including proper estimation of the fit errors. We use the method to fit 15GHzlight curves obtained within the OVRO 40-m blazar monitoring program where a large number of AGN have been monitored since 2008 in support of the Fermi Gamma-Ray Space Telescope mission. The time scales obtained from the fitted models are used to calculate the variability brightness temperature of the sources. Additionally, we have calculated brightness temperatures of a sample of these objects using Very Long Baseline Array data from the MOJAVE survey. Combining these two data sets enables us to study the intrinsic brightness temperature distribution in these blazars at 15 GHz. Our preliminary results indicate that the mean intrinsic brightness temperature in a sample of 14 sources is near the equipartition brightness temperature of ~ 1011K.

  13. Blazar spectral variability as explained by a twisted inhomogeneous jet.

    Science.gov (United States)

    Raiteri, C M; Villata, M; Acosta-Pulido, J A; Agudo, I; Arkharov, A A; Bachev, R; Baida, G V; Benítez, E; Borman, G A; Boschin, W; Bozhilov, V; Butuzova, M S; Calcidese, P; Carnerero, M I; Carosati, D; Casadio, C; Castro-Segura, N; Chen, W-P; Damljanovic, G; D'Ammando, F; Di Paola, A; Echevarría, J; Efimova, N V; Ehgamberdiev, Sh A; Espinosa, C; Fuentes, A; Giunta, A; Gómez, J L; Grishina, T S; Gurwell, M A; Hiriart, D; Jermak, H; Jordan, B; Jorstad, S G; Joshi, M; Kopatskaya, E N; Kuratov, K; Kurtanidze, O M; Kurtanidze, S O; Lähteenmäki, A; Larionov, V M; Larionova, E G; Larionova, L V; Lázaro, C; Lin, C S; Malmrose, M P; Marscher, A P; Matsumoto, K; McBreen, B; Michel, R; Mihov, B; Minev, M; Mirzaqulov, D O; Mokrushina, A A; Molina, S N; Moody, J W; Morozova, D A; Nazarov, S V; Nikolashvili, M G; Ohlert, J M; Okhmat, D N; Ovcharov, E; Pinna, F; Polakis, T A; Protasio, C; Pursimo, T; Redondo-Lorenzo, F J; Rizzi, N; Rodriguez-Coira, G; Sadakane, K; Sadun, A C; Samal, M R; Savchenko, S S; Semkov, E; Skiff, B A; Slavcheva-Mihova, L; Smith, P S; Steele, I A; Strigachev, A; Tammi, J; Thum, C; Tornikoski, M; Troitskaya, Yu V; Troitsky, I S; Vasilyev, A A; Vince, O

    2017-12-21

    Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancement and contraction of the variability timescales, so that most blazars appear as luminous sources characterized by noticeable and fast changes in brightness at all frequencies. The mechanism that produces this unpredictable variability is under debate, but proposed mechanisms include injection, acceleration and cooling of particles, with possible intervention of shock waves or turbulence. Changes in the viewing angle of the observed emitting knots or jet regions have also been suggested as an explanation of flaring events and can also explain specific properties of blazar emission, such as intra-day variability, quasi-periodicity and the delay of radio flux variations relative to optical changes. Such a geometric interpretation, however, is not universally accepted because alternative explanations based on changes in physical conditions-such as the size and speed of the emitting zone, the magnetic field, the number of emitting particles and their energy distribution-can explain snapshots of the spectral behaviour of blazars in many cases. Here we report the results of optical-to-radio-wavelength monitoring of the blazar CTA 102 and show that the observed long-term trends of the flux and spectral variability are best explained by an inhomogeneous, curved jet that undergoes changes in orientation over time. We propose that magnetohydrodynamic instabilities or rotation of the twisted jet cause different jet regions to change their orientation and hence their relative Doppler factors. In particular, the extreme optical outburst of 2016-2017 (brightness increase of six magnitudes) occurred when the corresponding emitting region had a small viewing angle

  14. Blazar spectral variability as explained by a twisted inhomogeneous jet

    Science.gov (United States)

    Raiteri, C. M.; Villata, M.; Acosta-Pulido, J. A.; Agudo, I.; Arkharov, A. A.; Bachev, R.; Baida, G. V.; Benítez, E.; Borman, G. A.; Boschin, W.; Bozhilov, V.; Butuzova, M. S.; Calcidese, P.; Carnerero, M. I.; Carosati, D.; Casadio, C.; Castro-Segura, N.; Chen, W.-P.; Damljanovic, G.; D'Ammando, F.; di Paola, A.; Echevarría, J.; Efimova, N. V.; Ehgamberdiev, Sh. A.; Espinosa, C.; Fuentes, A.; Giunta, A.; Gómez, J. L.; Grishina, T. S.; Gurwell, M. A.; Hiriart, D.; Jermak, H.; Jordan, B.; Jorstad, S. G.; Joshi, M.; Kopatskaya, E. N.; Kuratov, K.; Kurtanidze, O. M.; Kurtanidze, S. O.; Lähteenmäki, A.; Larionov, V. M.; Larionova, E. G.; Larionova, L. V.; Lázaro, C.; Lin, C. S.; Malmrose, M. P.; Marscher, A. P.; Matsumoto, K.; McBreen, B.; Michel, R.; Mihov, B.; Minev, M.; Mirzaqulov, D. O.; Mokrushina, A. A.; Molina, S. N.; Moody, J. W.; Morozova, D. A.; Nazarov, S. V.; Nikolashvili, M. G.; Ohlert, J. M.; Okhmat, D. N.; Ovcharov, E.; Pinna, F.; Polakis, T. A.; Protasio, C.; Pursimo, T.; Redondo-Lorenzo, F. J.; Rizzi, N.; Rodriguez-Coira, G.; Sadakane, K.; Sadun, A. C.; Samal, M. R.; Savchenko, S. S.; Semkov, E.; Skiff, B. A.; Slavcheva-Mihova, L.; Smith, P. S.; Steele, I. A.; Strigachev, A.; Tammi, J.; Thum, C.; Tornikoski, M.; Troitskaya, Yu. V.; Troitsky, I. S.; Vasilyev, A. A.; Vince, O.

    2017-12-01

    Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancement and contraction of the variability timescales, so that most blazars appear as luminous sources characterized by noticeable and fast changes in brightness at all frequencies. The mechanism that produces this unpredictable variability is under debate, but proposed mechanisms include injection, acceleration and cooling of particles, with possible intervention of shock waves or turbulence. Changes in the viewing angle of the observed emitting knots or jet regions have also been suggested as an explanation of flaring events and can also explain specific properties of blazar emission, such as intra-day variability, quasi-periodicity and the delay of radio flux variations relative to optical changes. Such a geometric interpretation, however, is not universally accepted because alternative explanations based on changes in physical conditions—such as the size and speed of the emitting zone, the magnetic field, the number of emitting particles and their energy distribution—can explain snapshots of the spectral behaviour of blazars in many cases. Here we report the results of optical-to-radio-wavelength monitoring of the blazar CTA 102 and show that the observed long-term trends of the flux and spectral variability are best explained by an inhomogeneous, curved jet that undergoes changes in orientation over time. We propose that magnetohydrodynamic instabilities or rotation of the twisted jet cause different jet regions to change their orientation and hence their relative Doppler factors. In particular, the extreme optical outburst of 2016–2017 (brightness increase of six magnitudes) occurred when the corresponding emitting region had a small viewing

  15. Circular Polarization in Turbulent Blazar Jets

    Directory of Open Access Journals (Sweden)

    Nicholas Roy MacDonald

    2017-11-01

    Full Text Available Circular polarization (CP provides an invaluable probe into the underlying plasma content of relativistic jets. CP can be generated within the jet through a physical process known as linear birefringence. This is a physical mechanism through which initially linearly polarized emission produced in one region of the jet is attenuated by Faraday rotation as it passes through other regions of the jet with distinct magnetic field orientations. Marscher developed the turbulent extreme multi-zone (TEMZ model of blazar emission which mimics these types of magnetic geometries with collections of thousands of plasma cells passing through a standing conical shock. I have recently developed a radiative transfer algorithm to generate synthetic images of the time-dependent circularly polarized intensity emanating from the TEMZ model at different radio frequencies. In this study, we produce synthetic multi-epoch observations that highlight the temporal variability in the circular polarization produced by the TEMZ model. We also explore the effect that different plasma compositions within the jet have on the resultant levels of CP.

  16. Unresolved Blazar Component of the Extragalactic Gamma-Ray Background

    Science.gov (United States)

    Stecker, Floyd W.; Venters, T. M.

    2011-01-01

    We present new theoretical estimates of the relative contribution of unresolved blazars and star forming galaxies to the extragalactic gamma-ray background and discuss constraints on the contributions from other possible components. We find that the Fermi data do not rule out a scenario in which the extragalactic gamma-ray background is dominated by emission from unresolved blazars. The spectrum of unresolved FSRQs, when accounting for the energy dependent effects of source confusion, could be consistent with the combined spectrum of the low energy EGRET extragalactic gamma-ray background measurements and the Fermi-LAT measurements above 200 MeV.

  17. What We Talk about When We Talk about Blazars?

    Directory of Open Access Journals (Sweden)

    Luigi Foschini

    2017-07-01

    Full Text Available After the discovery of powerful relativistic jets from Narrow-Line Seyfert 1 Galaxies, and the understanding of their similarity with those of blazars, a problem of terminology was born. The word blazar is today associated to BL Lac Objects and Flat-Spectrum Radio Quasars, which are somehow different from Narrow-Line Seyfert 1 Galaxies. Using the same word for all the three classes of AGN could drive either toward some misunderstanding, or to the oversight of some important characteristics. I review the main characteristics of these sources, and finally I propose a new scheme of classification.

  18. Preface: STATPHYS-Kolkata VII

    Science.gov (United States)

    Bhattacharjee, Jayanta Kumar; Chakrabarti, Bikas K.; Inoue, Jun-Ichi; Sen, Parongama

    2011-04-01

    In the past two decades, a series of international conferences on Statistical Physics, going by the name Statphys Kolkata, have been organized in Kolkata (previously Calcutta) at roughly three-year intervals, the first one being held in 1992-93. The seventh of this series, Statphys Kolkata VII (http://www.saha.ac.in/cmp/stat.vii/index.php) was held from 26-30 November 2010. This meeting was organized as part of the Silver Jubilee Celebration of the Satyendra Nath Bose National Centre for Basic Sciences, Kolkata, in collaboration with the Saha Institute of Nuclear Physics, Kolkata. In Statphys Kolkata VII, a few topics of current interest such as Collective behavior and emergent phenomena, Systems far from equilibrium, Soft matter, and Quantum critical phenomena were given special emphasis, while various other issues of Statistical Physics were also addressed. We were happy to note that the conference attracted a large number of participants, and the talk and poster sessions generated a lot of discussions, arguments and collaborations. The articles appearing in this proceedings are based on the invited talks and selected poster presentations. We would like to thank the Journal of Physics Conference Series, IOP, for publishing the proceedings of the conference, and the referees for their prompt and active support. The proceedings of the earlier Statphys Kolkata conferences have appeared in Physica A, vol 384 (2007); Physica A, vol 346 (2005); Physica A, vol 318 (2003); Physica A, vol 270 (1999); Physica A, vol 224 (1996); and Physica A, vol 186 (1992). We would like to take this opportunity to thank all the members of the organizing committee (especially Dr Anjan Kumar Chandra for extensive all-round help), and acknowledge the Centre for Applied Mathematics and Computational Science (CAMCS, Saha Institute of Nuclear Physics, Kolkata) and Satyendra Nath Bose National Centre for Basic Sciences, Kolkata, for their financial support. Jayanta Kumar Bhattacharjee, Bikas K

  19. The recent NIR Flare of the Blazar 3C279

    Science.gov (United States)

    Carrasco, L.; Recillas, E.; Porras, A.; Escobedo, G.; Chavushyan, V.

    2018-02-01

    In our monitoring campaign of AGNs we found the Blazar 3C279 flaring in the NIR on January 27th,2018. this source is cross identified with the quasar HB891253-055 and the Gamma-ray source 3FGLJ1256.1-054.

  20. Relation between Radio Polarization and Spectral Index of Blazars ...

    Indian Academy of Sciences (India)

    ties, including rapid variability, high and variability polarization, high luminosity and superluminal motion, etc. Their optical variability timescales can cover a range of hours to years from radio to γ-rays (Fan et al. 2004; Ulrich et al. 1997). When we analyse the different characters of blazars, spectral index (α) is very important.

  1. Gamma-Ray and Multiwavelength Emission from Blazars Meg Urry

    Indian Academy of Sciences (India)

    Aperture Research Telescope System, located in Cerro Tololo, Chile, which is a set of five telescopes, each with unique optical and/or near-infrared instrumentation. (ANDICAM; Depoy et al. 2003). We used the SMARTS 1.3 m + ANDICAM to obtain simultaneous 0.4–2.2 m images of 3C454.3 and other southern blazars in.

  2. Long-term optical-infrared color variability of blazars

    International Nuclear Information System (INIS)

    Zhang, Bing-Kai; Zhou, Xiao-Shan; Zhao, Xiao-Yun; Dai, Ben-Zhong

    2015-01-01

    The long-term optical and infrared color variability of blazars has been investigated with monitoring data from the Small and Moderate Aperture Research Telescope System (SMARTS). The sample in this study consists of 49 flat spectrum radio quasars (FSRQs) and 22 BL Lacertae objects (BL Lacs). The fractional variability amplitudes of each source have been calculated in both optical R band and infrared J band. Overall, the variability amplitudes of FSRQs are larger than those of BL Lacs. The results also suggest that the variability amplitude of most FSRQs is larger at a lower energy band (J band) than at a higher one (R band), but the variability amplitude of BL Lacs is larger at the higher energy band. Both types of blazars display color variation along with variability in brightness. However, they show different variation behaviors in general. In the whole data set, 35 FSRQs exhibit redder-when-brighter trends, and 11 FSRQs exhibit opposite trends; 11 BL Lacs follow bluer-when-brighter trends, and seven BL Lacs follow opposite trends. A detailed examination indicates that there are 10 blazars showing redder-when-brighter trends in their low state, and bluer-when-brighter or stable-when-brighter trends in their high state. Some more complicated color behaviors have also been detected in several blazars. The non-thermal jet emission and the thermal emission from the accretion disk are employed to explain the observed color behaviors. (paper)

  3. Relation between Radio Polarization and Spectral Index of Blazars ...

    Indian Academy of Sciences (India)

    Introduction. Blazars are a very special class of extragalactic objects showing some special proper- ties, including rapid variability, high and variability polarization, high luminosity and superluminal motion, etc. Their optical variability timescales can cover a range of hours to years from radio to γ-rays (Fan et al. 2004; Ulrich ...

  4. Quasi Periodic Oscillations in Blazars Alok C. Gupta

    Indian Academy of Sciences (India)

    QPOs) in blazars time series data in X-ray and optical elec- tromagnetic bands. Any such detection can give important clues of the location and nature of the processes of emission mechanism. In the case of radio-quiet AGN, the detected QPOs ...

  5. Quasi Periodic Oscillations in Blazars Alok C. Gupta

    Indian Academy of Sciences (India)

    -quiet AGN .... blazar S5 0716 + 714, simultaneous optical and radio QPO were detected on ∼1 day timescale (Quirrenbach et al. ... beration mapping method which gives a mass of about 2.4 × 108M⊙ (Kaspi et al. 2000). Due to the substantial ...

  6. High-redshift Blazars through NuSTAR Eyes

    International Nuclear Information System (INIS)

    Marcotulli, L.; Paliya, V. S.; Ajello, M.; Kaur, A.; Hartmann, D. H.; Gasparrini, D.; Greiner, J.; Rau, A.; Schady, P.; Baloković, M.; Stern, D.; Madejski, G.

    2017-01-01

    The most powerful sources among the blazar family are MeV blazars. Often detected at z > 2, they usually display high X- and γ -ray luminosities, larger-than-average jet powers, and black hole masses ≳10 9 M ☉ . In the present work, we perform a multiwavelength study of three high-redshift blazars: 3FGL J0325.5+2223 ( z = 2.06), 3FGL J0449.0+1121 ( z = 2.15), and 3FGL J0453.2−2808 ( z = 2.56), analyzing quasi-simultaneous data from GROND, Swift -UVOT and XRT, Nuclear Spectroscopic Telescope Array ( NuSTAR ), and Fermi -LAT. Our main focus is on the hard X-ray band recently unveiled by NuSTAR (3–79 keV) where these objects show a hard spectrum that enables us to constrain the inverse Compton (IC) peak and the jet power. We found that all three targets resemble the most powerful blazars, with the synchrotron peak located in the submillimeter range and the IC peak in the MeV range, and therefore belong to the MeV blazar class. Using a simple one-zone leptonic emission model to reproduce the spectral energy distributions, we conclude that a simple combination of synchrotron and accretion disk emission reproduces the infrared–optical spectra, while the X-ray to γ -ray part is well reproduced by the IC scattering of low-energy photons supplied by the broad-line region. The black hole masses for each of the three sources are calculated to be ≳4 × 10 8 M ☉ . The three studied sources have jet power at the level of, or beyond, the accretion luminosity.

  7. IDENTIFICATION OF NEW GAMMA-RAY BLAZAR CANDIDATES WITH MULTIFREQUENCY ARCHIVAL OBSERVATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Cowperthwaite, Philip S. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Massaro, F. [SLAC National Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); D' Abrusco, R.; Paggi, A.; Smith, Howard A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Tosti, G., E-mail: pcowpert@umd.edu [Dipartimento di Fisica, Università Degli Studi di Perugia, I-06123 Perugia (Italy)

    2013-11-01

    Blazars are a highly variable, radio-loud subclass of active galactic nuclei. In order to better understand such objects we must be able to easily identify candidate blazars from the growing population of unidentified sources. Working toward this goal, we attempt to identify new gamma-ray blazar candidates from a sample of 102 previously unidentified sources. These sources are selected from The Astronomer's Telegram and the literature on the basis of non-periodic variability and multi-wavelength behavior. We then attempt to associate these objects to an IR counterpart in the Wide-field Infrared Survey Explorer all-sky survey. We are able to identify 16 candidate sources whose IR colors are consistent with those of the blazar population. Of those, 13 sources have IR colors indicative of being gamma-ray emitting blazar candidates. These sources all possess archival multi-wavelength observations that support their blazar-like nature.

  8. Data reduction and analysis of the multiband optical images of the blazar Mrk180

    Directory of Open Access Journals (Sweden)

    M Sabzi Sarvestani

    2012-09-01

    Full Text Available  Nearly simultaneous multiband monitoring of blazars is very limited and most studies reported in literature are conflicting, too. Although optical variability on intra-night timescales is now a well established phenomenon for blazars, its relationship to long-term variability remains unclear. Possible clues could come from monitoring the optical spectrum for correlation with brightness. The presence or absence of bluer color in blazar color index, when its luminosity is increased on intra-night and inter-night timescales, can provide interesting clues to the origin of blazar variability from hourly to much longer timescales. Luminosity of blazars varies at all wavelengths over a variety of timescales. Various models have been proposed to explain blazar variability. However, the mechanism responsible for variability is not conclusively understood. One factor which can discriminate the various variability models is that of color (spectral index variations of blazars. This factor may help to better understand the mechanism of blazar variability. Therefore, it was initially proposed, by the second author of this paper to the OHP observatory, to carry out quasi-simultaneous multiband monitoring of one of the brightest blazer, Mrk180. Fortunately, it was accepted by the scientific team of the observatory and the 1.20m telescope time was allocated to the project from 23 to 28 April 2009. Because of the weather conditions, we could only monitor this blazar for three nights. Raw data processing and data reduction were performed using the standard system of Europe Southerner Observatory, ESO-MIDAS. We considered two reference stars and measured the magnitudes of the reference stars and the blazar Mrk 180 and then plotted the light curves and the color index diagrams. The light curves showed the optical variations of the blazar. The maximum amplitude value of its variations was 0.185 mag for the V filter. Investigating the blazar color index shows its

  9. 5-day photo-polarimetric WEBT Campaign on Blazar S5 0716+714 - a Study of Microvariabiltiy in Blazar

    Science.gov (United States)

    Bhatta, Gopal; Ostrwoski, Michal; Stawarz, Lukasz; Zola, Staszek; Jableka, Damian; Bachev, R.; Benitez, Erika; Dhalla, Sarah M.; Cason, Andy; Carosati, Daniele; Damljanovic, Goran; Frasca, A.; Hu, Shao Ming; Jorstad, Svetlana G.; Kurtanidze, O.; Larionov, Valeri; Leto, Giuseppe; Marscher, Alan P.; Moody, Joseph; Ohlert, Johhanes; Rizzi, Nicola; Sadun, Alberto C.; Sasada, Mahito; Sergeev, Sergey; Strigachev, Anton; Vince, Oliver; Webb, James Raymond; Whole Earth Blazar Telescope

    2015-01-01

    A whole earth blazar telescope (WEBT) campaign on blazar S5 0716+714 was organized to simultaneously monitor the source in multiple photo-polarimetric filters as a study of the nature of microvariability in blazar. The campaign, starting on March 2nd 2014, lasted for five consecutive days resulting in a rich data set- flux in B,V,R,I and near IR filters, and polarization degree (PD) and position angle (PA) in mainly R filter. Such a rich information provides with an unique opportunity to look deep into the localized emission regions in the jet of the blazar. During the campaign, the source remained active with 0.93 duty cycle and went through an oscillation of 0.3 magnitudes along with 5% change in PD and 50 degrees swing in PA. For 6.19 hrs the activity suddenly stopped in all the filters resulting in a plateau around 14 magnitudes in R filter light curve and then brightens by 0.14 mag in 2.96 hr time. We employed time series analysis in search of possible quasi-periodic oscillations and found some of the significant timescales present in the light curve which could reflect on the physical processes in the turbulent jet environment. In the color-magnitude analysis, we looked for 'bluer-when-brighter' trend widely claimed to be found in some of the blazars including the source. Although we found some of such incidences, they could not claimed to be persistent through out the campaign period. Similarly, no clear trend of correlation between flux and PD, and flux and PA could be established. A modeling of the mini-flares lasting few hours as stochastic synchrotron pulses on top of relative stable back ground emission and that incorporates simultaneous the change of color, PA and PD is underway.

  10. Factor VII-activating protease

    DEFF Research Database (Denmark)

    Ramanathan, Ramshanker; Gram, Jørgen B; Sand, Niels Peter R

    2017-01-01

    : Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens...... aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined...... the Agatston score, dividing the study population in three groups: (1) Agatston score = 0 U, (2) Agatston score = 1-99 U, or (3) Agatston score more than 99 U. A total of 134 women and 116 men were included. Total FSAP, FSAP GP, and specific FSAP activity were independently higher in women (97.4%, 81.1%, 0...

  11. Pengaruh Penerapan Pembelajaran Arias Dipadu Mind Map terhadap Hasil Belajar Kognitif Siswa Kelas VII

    OpenAIRE

    Leliavia, Leliavia; Al Muhdhar, Mimien Henie Irawati; Suwono, Hadi

    2017-01-01

    This research was to determine the effect of differences ARIAS combined mind map learning and ARIAS learning to cognitive learning outcomes grade VII SMPN 1 Tempunak. This research with quasy research experiment design approach with the design of pretest-posttest. Data were analyzed using descriptive statistics and inferensial to test the hypothesis that analysis of covariance (ANCOVA) using SPSS 23 for windows with a significance level of 0,05. The study was conducted at the grade VII SMPN 1...

  12. Blazar Jets Push Closer to Cosmic Speed Limit

    Science.gov (United States)

    2005-01-01

    Astronomers using the National Science Foundation's Very Long Baseline Array (VLBA) have discovered jets of plasma blasted from the cores of distant galaxies at speeds within one-tenth of one percent of the speed of light, placing these plasma jets among the fastest objects yet seen in the Universe. "This tells us that the physical processes at the cores of these galaxies, called blazars, are extremely energetic and are capable of propelling matter very close to the absolute cosmic speed limit," said Glenn Piner of Whittier College in Whittier, California. Piner, who worked on the project with student Dipesh Bhattari, also of Whittier College, Philip Edwards of the Japan Aerospace Exploration Agency, and Dayton Jones of NASA's Jet Propulsion Laboratory, presented their findings to the American Astronomical Society's meeting in San Diego, California. According to Einstein's Special Theory of Relativity, no object with mass can be accelerated to the speed of light. To get even close to the speed of light requires enormous amounts of energy. "For example, to accelerate a bowling ball to the speed newly measured in these blazars would require all the energy produced in the world for an entire week," Piner said, "and the blobs of plasma in these jets are at least as massive as a large planet". Blazars are active galactic nuclei -- energetic regions surrounding massive black holes at the centers of galaxies. Material being drawn into the black hole forms a spinning disk called an accretion disk. Powerful jets of charged particles are ejected at high speeds along the poles of accretion disks. When these jets happen to be aimed nearly toward the Earth, the objects are called blazars. Taking advantage of the extremely sharp radio "vision" of the continent-wide VLBA, the scientists tracked individual features in the jets of three blazars at distances from Earth ranging from 7.3 to 9 billion light-years. A Boston University team led by Svetlana Jorstad earlier had identified

  13. QUASI-PERIODICITIES AT YEAR-LIKE TIMESCALES IN BLAZARS

    Energy Technology Data Exchange (ETDEWEB)

    Sandrinelli, A.; Treves, A. [Università degli Studi dell’Insubria, Dipartimento di Scienza ed Alta Tecnologia, Via Valleggio 11, I-22100 Como (Italy); Covino, S. [INAF—Istituto Nazionale di Astrofisica, Osservatorio Astronomico di Brera, Via Emilio Bianchi 46, I-23807 Merate (Italy); Dotti, M. [Università degli Studi di Milano Bicocca, Dipartimento di Fisica G. Occhialini, Piazza della Scienza 3, I-20126 Milano (Italy)

    2016-03-15

    We searched for quasi-periodicities on year-like timescales in the light curves of six blazars in the optical—near-infrared bands and we made a comparison with the high energy emission. We obtained optical/NIR light curves from Rapid Eye Mounting photometry plus archival Small and Moderate Aperture Research Telescope System data and we accessed the Fermi light curves for the γ-ray data. The periodograms often show strong peaks in the optical and γ-ray bands, which in some cases may be inter-related. The significance of the revealed peaks is then discussed, taking into account that the noise is frequency dependent. Quasi-periodicities on a year-like timescale appear to occur often in blazars. No straightforward model describing these possible periodicities is yet available, but some plausible interpretations for the physical mechanisms causing periodic variabilities of these sources are examined.

  14. The broadband spectral energy distributions of SDSS blazars

    Science.gov (United States)

    Li, Huai-Zhen; Chen, Luo-En; Jiang, Yun-Guo; Yi, Ting-Feng

    2015-07-01

    We compiled the radio, optical and X-ray data of blazars from the Sloan Digital Sky Survey database, and presented the distribution of luminosities and broadband spectral indices. The distribution of luminosities shows that the averaged luminosity of flat spectrum radio quasars (FSRQs) is larger than that of BL Lacertae (BL Lac) objects. On the other hand, the broadband spectral energy distribution reveals that FSRQs and low energy peaked BL Lac objects have similar spectral properties, but high energy peaked BL Lac objects have a distinct spectral property. This may be due to the fact that different subclasses of blazars have different intrinsic environments and are at different cooling levels. Even so, a unified scheme is also revealed from the color-color diagram, which hints that there are similar physical processes operating in all objects under a range of intrinsic physical conditions or beaming parameters. Supported by the National Natural Science Foundation of China.

  15. RELAXATION OF BLAZAR-INDUCED PAIR BEAMS IN COSMIC VOIDS

    Energy Technology Data Exchange (ETDEWEB)

    Miniati, Francesco [Physics Department, Wolfgang-Pauli-Strasse 27, ETH-Zuerich, CH-8093 Zuerich (Switzerland); Elyiv, Andrii, E-mail: fm@phys.ethz.ch [Institut d' Astrophysique et de Geophysique, Universite de Liege, B-4000 Liege (Belgium)

    2013-06-10

    The stability properties of a low-density ultrarelativistic pair beam produced in the intergalactic medium (IGM) by multi-TeV gamma-ray photons from blazars are analyzed. The problem is relevant for probes of magnetic field in cosmic voids through gamma-ray observations. In addition, dissipation of such beams could considerably affect the thermal history of the IGM and structure formation. We use a Monte Carlo method to quantify the properties of the blazar-induced electromagnetic shower, in particular the bulk Lorentz factor and the angular spread of the pair beam generated by the shower, as a function of distance from the blazar itself. We then use linear and nonlinear kinetic theory to study the stability of the pair beam against the growth of electrostatic plasma waves, employing the Monte Carlo results for our quantitative estimates. We find that the fastest growing mode, like any perturbation mode with even a very modest component perpendicular to the beam direction, cannot be described in the reactive regime. Due to the effect of nonlinear Landau damping, which suppresses the growth of plasma oscillations, the beam relaxation timescale is found to be significantly longer than the inverse Compton loss time. Finally, density inhomogeneities associated with cosmic structure induce loss of resonance between the beam particles and plasma oscillations, strongly inhibiting their growth. We conclude that relativistic pair beams produced by blazars in the IGM are stable on timescales that are long compared with the electromagnetic cascades. There appears to be little or no effect of pair beams on the IGM.

  16. Steady-state emission of blazars at very high energies

    International Nuclear Information System (INIS)

    Hoehne-Moench, Daniel

    2010-01-01

    One key scientific program of the MAGIC telescope project is the discovery and detection of blazars. They constitute the most prominent extragalactic source class in the very high energy (VHE) γ-ray regime with 29 out of 34 known objects. Therefore a major part of the available observation time was spent in the last years on high-frequency peaked blazars. The selection criteria were chosen to increase the detection probability. As the X-ray flux is believed to be correlated to the VHE γ-ray flux, only X-ray selected sources with a flux F X >2 μJy at 1 keV were considered. To avoid strong attenuation of the -rays in the extragalactic infrared background, the redshift was restricted to values between z X-γ between the X-ray range at 1 keV and the VHE γ-ray regime at 200 GeV were calculated. The majority of objects show a spectral behaviour as expected from the source class of HBLs: The energy output in the VHE regime is in general lower than in X-rays. For the stacked blazar sample the broad-band spectral index was calculated to α X-γ =1.09, confirming the result found for the individual objects. Another evidence for the revelation of the baseline emission is the broad-band spectral energy distribution (SED) comprising archival as well as contemporaneous multi-wavelength data from the radio to the VHE band. The SEDs of known VHE γ-ray sources in low flux states matches well the SED of the stacked blazar sample. (orig.)

  17. Modeling Blazar Spectra by Solving an Electron Transport Equation

    Science.gov (United States)

    Lewis, Tiffany; Finke, Justin; Becker, Peter A.

    2018-01-01

    Blazars are luminous active galaxies across the entire electromagnetic spectrum, but the spectral formation mechanisms, especially the particle acceleration, in these sources are not well understood. We develop a new theoretical model for simulating blazar spectra using a self-consistent electron number distribution. Specifically, we solve the particle transport equation considering shock acceleration, adiabatic expansion, stochastic acceleration due to MHD waves, Bohm diffusive particle escape, synchrotron radiation, and Compton radiation, where we implement the full Compton cross-section for seed photons from the accretion disk, the dust torus, and 26 individual broad lines. We used a modified Runge-Kutta method to solve the 2nd order equation, including development of a new mathematical method for normalizing stiff steady-state ordinary differential equations. We show that our self-consistent, transport-based blazar model can qualitatively fit the IR through Fermi g-ray data for 3C 279, with a single-zone, leptonic configuration. We use the solution for the electron distribution to calculate multi-wavelength SED spectra for 3C 279. We calculate the particle and magnetic field energy densities, which suggest that the emitting region is not always in equipartition (a common assumption), but sometimes matter dominated. The stratified broad line region (based on ratios in quasar reverberation mapping, and thus adding no free parameters) improves our estimate of the location of the emitting region, increasing it by ~5x. Our model provides a novel view into the physics at play in blazar jets, especially the relative strength of the shock and stochastic acceleration, where our model is well suited to distinguish between these processes, and we find that the latter tends to dominate.

  18. BLAZAR OPTICAL VARIABILITY IN THE PALOMAR-QUEST SURVEY

    International Nuclear Information System (INIS)

    Bauer, Anne; Baltay, Charles; Coppi, Paolo; Ellman, Nancy; Jerke, Jonathan; Rabinowitz, David; Scalzo, Richard

    2009-01-01

    We study the ensemble optical variability of 276 flat-spectrum radio quasars (FSRQs) and 86 BL Lacs in the Palomar-QUEST Survey with the goal of searching for common fluctuation properties, examining the range of behavior across the sample, and characterizing the appearance of blazars in such a survey so that future work can more easily identify such objects. The survey, which covers 15,000 deg 2 multiple times over 3.5 years, allows for the first ensemble blazar study of this scale. Variability amplitude distributions are shown for the FSRQ and BL Lac samples for numerous time lags, and also studied through structure function analyses. Individual blazars show a wide range of variability amplitudes, timescales, and duty cycles. Of the best-sampled objects, 35% are seen to vary by more than 0.4 mag; for these, the fraction of measurements contributing to the high-amplitude variability ranges constantly from about 5% to 80%. Blazar variability has some similarities to that of type I quasi-stellar objects (QSOs) but includes larger amplitude fluctuations on all timescales. FSRQ variability amplitudes are particularly similar to those of QSOs on timescales of several months, suggesting significant contributions from the accretion disk to the variable flux at these timescales. Optical variability amplitudes are correlated with the maximum apparent velocities of the radio jet for the subset of FSRQs with MOJAVE Very Long Baseline Array measurements, implying that the optically variable flux's strength is typically related to that of the radio emission. We also study CRATES radio-selected FSRQ candidates, which show similar variability characteristics to known FSRQs; this suggests a high purity for the CRATES sample.

  19. Fast γ-Ray Variability in Blazars beyond Redshift 3

    Science.gov (United States)

    Li, Shang; Xia, Zi-Qing; Liang, Yun-Feng; Liao, Neng-Hui; Fan, Yi-Zhong

    2018-02-01

    High-redshift blazars are one of the most powerful sources in the universe and γ-ray variability carries crucial information about their relativistic jets. In this work we present results of the first systematical temporal analysis of Fermi-LAT data of all known seven γ-ray blazars beyond redshift 3. Significant long-term γ-ray variability is found from five sources in monthly γ-ray light curves, in which three of them are reported for the first time. Furthermore, intraday γ-ray variations are detected from NVSS J053954‑283956 and NVSS J080518+614423. The doubling variability timescale of the former source is limited as short as ≲1 hr (at the source frame). Together with variability amplitude over one order of magnitude, NVSS J053954‑283956 is the most distant γ-ray flaring blazar so far. Meanwhile, intraday optical variability of NVSS J163547+362930 is found based on an archival PTF/iPTF light curve. Benefiting from the multi-wavelength activity of these sources, constraints on their Doppler factors, as well as the locations of the γ-ray radiation region and indications for the SDSS high redshift jetted active galactic nuclei deficit are discussed.

  20. Correlation between γ-Ray and Radio Bands for γ-Ray Loud Blazars ...

    Indian Academy of Sciences (India)

    Abstract. The most identified sources observed by Fermi are blazars. (Flat Spectrum Radio Quasars (FSRQs) and BL Lacertae objects (BLs). In this paper, we obtained 124 γ-ray loud blazars with available γ-ray and radio (core and total) data. It is interesting that the γ-ray luminosity have a good correlation with the radio ...

  1. UV and X-ray Variability of Blazars Alok C. Gupta

    Indian Academy of Sciences (India)

    Abstract. It is well established that the blazars show flux variations in the complete electromagnetic (EM) spectrum on all possible time scales ranging from a few tens of minutes to several years. Here we report the review of various UV and X-ray flux variability properties of blazars. Our analysis show that UV variability ...

  2. Correlation between γ-Ray and Radio Bands for γ-Ray Loud Blazars ...

    Indian Academy of Sciences (India)

    J. H. Fan & S. H. Li. Centre for Astrophysics, Guangzhou University, Guangzhou 510006, China. ∗ e-mail: dxwuhl@gmail.com. Abstract. The most identified sources observed by Fermi are blazars. (Flat Spectrum Radio Quasars (FSRQs) and BL Lacertae objects (BLs). In this paper, we obtained 124 γ-ray loud blazars with ...

  3. Type VII collagen in Alport syndrome.

    Science.gov (United States)

    Giannakakis, Konstantinos; Massella, Laura; Grassetti, Daniele; Dotta, Francesco; Perez, Marie; Muda, Andrea Onetti

    2007-12-01

    Absence or segmental distribution of the alpha5(IV) collagen chain along the epidermal basement membrane (EBM) is diagnostic of X-linked Alport syndrome (X-AS), but the typical morphologic alterations usually observed along the glomerular basement membrane (GBM) are lacking. However, several differences in protein composition exist between GBM and EBM, and such differences could account for a different phenotype with the same genetic defect. Type VII collagen is one of the major collagenous components of the EBM; the purpose of this study was to investigate the modifications of protein synthesis and expression of type VII collagen in the skin of patients with X-AS. The distribution of type VII collagen has been studied in 15 skin biopsies (10 from X-AS patients and 5 controls) by means of electron microscopy, immunofluorescence and confocal microscopy; type VII collagen mRNA expression was also measured by RT-PCR on the same skin fragments. Protein and mRNA amounts for type VII collagen were significantly higher in skin samples from X-AS patients than in controls (P < 0.001); highest values were in cases in which alpha5(IV) was completely absent. Our results indicate that lack of alpha5(IV) molecule significantly alters the assembly of extracellular matrix molecules other than alphax(IV) chains also at the EBM level. We suggest that the increased synthesis and deposition of type VII collagen is likely to balance the absence of stabilizing activity normally exerted by alpha5(IV).

  4. Extended Radio Emission in MOJAVE Blazars: Challenges to Unification

    Science.gov (United States)

    Kharb, P.; Lister, M. L.; Cooper, N. J.

    2010-02-01

    We present the results of a study on the kiloparsec-scale radio emission in the complete flux density limited MOJAVE sample, comprising 135 radio-loud active galactic nuclei. New 1.4 GHz Very Large Array (VLA) radio images of six quasars and previously unpublished images of 21 blazars are presented, along with an analysis of the high-resolution (VLA A-array) 1.4 GHz emission for the entire sample. While extended emission is detected in the majority of the sources, about 7% of the sources exhibit only radio core emission. We expect more sensitive radio observations, however, to detect faint emission in these sources, as we have detected in the erstwhile "core-only" source, 1548+056. The kiloparsec-scale radio morphology varies widely across the sample. Many BL Lac objects exhibit extended radio power and kiloparsec-scale morphology typical of powerful FRII jets, while a substantial number of quasars possess radio powers intermediate between FRIs and FRIIs. This poses challenges to the simple radio-loud unified scheme, which links BL Lac objects to FRIs and quasars to FRIIs. We find a significant correlation between extended radio emission and parsec-scale jet speeds: the more radio powerful sources possess faster jets. This indicates that the 1.4 GHz (or low-frequency) radio emission is indeed related to jet kinetic power. Various properties such as extended radio power and apparent parsec-scale jet speeds vary smoothly between different blazar subclasses, suggesting that, at least in terms of radio jet properties, the distinction between quasars and BL Lac objects, at an emission-line equivalent width of 5 Å, is essentially an arbitrary one. While the two blazar subclasses display a smooth continuation in properties, they often reveal differences in the correlation test results when considered separately. This can be understood if, unlike quasars, BL Lac objects do not constitute a homogeneous population, but rather include both FRI and FRII radio galaxies for

  5. EXTENDED RADIO EMISSION IN MOJAVE BLAZARS: CHALLENGES TO UNIFICATION

    International Nuclear Information System (INIS)

    Kharb, P.; Lister, M. L.; Cooper, N. J.

    2010-01-01

    We present the results of a study on the kiloparsec-scale radio emission in the complete flux density limited MOJAVE sample, comprising 135 radio-loud active galactic nuclei. New 1.4 GHz Very Large Array (VLA) radio images of six quasars and previously unpublished images of 21 blazars are presented, along with an analysis of the high-resolution (VLA A-array) 1.4 GHz emission for the entire sample. While extended emission is detected in the majority of the sources, about 7% of the sources exhibit only radio core emission. We expect more sensitive radio observations, however, to detect faint emission in these sources, as we have detected in the erstwhile 'core-only' source, 1548+056. The kiloparsec-scale radio morphology varies widely across the sample. Many BL Lac objects exhibit extended radio power and kiloparsec-scale morphology typical of powerful FRII jets, while a substantial number of quasars possess radio powers intermediate between FRIs and FRIIs. This poses challenges to the simple radio-loud unified scheme, which links BL Lac objects to FRIs and quasars to FRIIs. We find a significant correlation between extended radio emission and parsec-scale jet speeds: the more radio powerful sources possess faster jets. This indicates that the 1.4 GHz (or low-frequency) radio emission is indeed related to jet kinetic power. Various properties such as extended radio power and apparent parsec-scale jet speeds vary smoothly between different blazar subclasses, suggesting that, at least in terms of radio jet properties, the distinction between quasars and BL Lac objects, at an emission-line equivalent width of 5 A, is essentially an arbitrary one. While the two blazar subclasses display a smooth continuation in properties, they often reveal differences in the correlation test results when considered separately. This can be understood if, unlike quasars, BL Lac objects do not constitute a homogeneous population, but rather include both FRI and FRII radio galaxies for

  6. Extraction of Tc(VII) and Re(VII) on TRU resin

    Energy Technology Data Exchange (ETDEWEB)

    Guerin, Nicolas; Riopel, Remi; Kramer-Tremblay, Sheila [Canadian Nuclear Laboratories (CNL), Chalk River, ON (Canada). Radiobiology and Health Branch; De Silva, Nimal; Cornett, Jack [Ottawa Univ., ON (Canada). Dept. of Earth and Environmental Sciences; Dai, Xiongxin [China Institute for Radiation Protection, Beijing (China)

    2017-06-01

    TRU resin can be used to rapidly and selectively extract Tc(VII) and Re(VII). The retention capacity curves of Tc(VII) and Re(VII) for HNO{sub 3}, HCl, H{sub 2}SO{sub 4} and H{sub 3}PO{sub 4} solutions were studied and prepared. Tc(VII) and Re(VII) were simultaneously extracted in 2 M H{sub 2}SO{sub 4} and 1.5 M H{sub 3}PO{sub 4} and were effectively separated from Mo(VI) and Ru(III). Tc(VII) and Re(VII) remained strongly bonded to the resin even after washing using a large volume of 2 M H{sub 2}SO{sub 4} at a relatively high flow rate. Also, they were both completely eluted from the resin using 15 mL of near boiling water, an eluent directly compatible for ICP-MS instrument measurements.

  7. TIMING SIGNATURES OF THE INTERNAL-SHOCK MODEL FOR BLAZARS

    International Nuclear Information System (INIS)

    Boettcher, M.; Dermer, C. D.

    2010-01-01

    We investigate the spectral and timing signatures of the internal-shock model for blazars. For this purpose, we develop a semi-analytical model for the time-dependent radiative output from internal shocks arising from colliding relativistic shells in a blazar jet. The emission through synchrotron and synchrotron-self Compton radiation as well as Comptonization of an isotropic external radiation field are taken into account. We evaluate the discrete correlation function (DCF) of the model light curves in order to evaluate features of photon-energy-dependent time lags and the quality of the correlation, represented by the peak value of the DCF. The almost completely analytic nature of our approach allows us to study in detail the influence of various model parameters on the resulting spectral and timing features. This paper focuses on a range of parameters in which the γ-ray production is dominated by Comptonization of external radiation, most likely appropriate for γ-ray bright flat-spectrum radio quasars (FSRQs) or low-frequency peaked BL Lac objects (LBLs). In most cases relevant for FSRQs and LBLs, the variability of the optical emission is highly correlated with the X-ray and high-energy (HE: > 100 MeV) γ-ray emission. Our baseline model predicts a lead of the optical variability with respect to the higher-energy bands by 1-2 hr and of the HE γ-rays before the X-rays by about 1 hr. We show that variations of certain parameters may lead to changing signs of inter-band time lags, potentially explaining the lack of persistent trends of time lags in most blazars.

  8. The radio-γ-ray connection in Fermi blazars

    Science.gov (United States)

    Ghirlanda, G.; Ghisellini, G.; Tavecchio, F.; Foschini, L.; Bonnoli, G.

    2011-05-01

    We study the correlation between the γ-ray flux (Fγ), averaged over the first 11 months of the Fermi survey and integrated above 100 MeV, and the radio flux density (Fr at 20 GHz) of Fermi sources associated with a radio counterpart in the 20-GHz Australia Telescope Compact Array (AT20G) survey. Considering the blazars detected in both bands, the correlation is highly significant and has the form Fγ∝F0.85±0.04r, similar to BL Lacertae objects and flat-spectrum radio quasars. However, only a small fraction (˜1/15) of the AT20G radio sources with flat radio spectra are detected by Fermi. To understand if this correlation is real, we examine the selection effects introduced by the flux limits of both the radio and the γ-ray surveys, and the importance of variability of the γ-ray flux. After accounting for these effects, we find that the radio-γ-ray flux correlation is real, but its slope is steeper than the observed one, that is, Fγ∝Fδr with δ in the range 1.25-1.5. The observed Fγ-Fr correlation and the fraction of radio sources detected by Fermi are reproduced assuming a long-term γ-ray flux variability, following a lognormal probability distribution with standard deviation σ≥ 0.5 (corresponding to Fγ varying by at least a factor of 3). Such a variability is compatible, even if not necessarily equal, with what is observed when comparing, for the sources in common, the EGRET and the Fermi γ-ray fluxes (even if the Fermi fluxes are averaged over ˜1 yr). Another indication of variability is the non-detection of 12 out of 66 EGRET blazars by Fermi, despite its higher sensitivity. We also study the strong linear correlation between the γ-ray and the radio luminosity of the 144 AT20G-Fermi associations with known redshift and show, through partial correlation analysis, that it is statistically robust. Two possible implications of these correlations are discussed: the contribution of blazars to the extragalactic γ-ray background and the prediction

  9. ANTARES Constrains a Blazar Origin of Two IceCube PeV Neutrino Events

    Science.gov (United States)

    Adrian-Martinez, S.; Albert, A.; André, M.; Anton, G.; Ardid, M.; Aubert, J. J.; Baret, B.; Barrios, J.; Basa, S.; Gehrels, N.; hide

    2015-01-01

    Context. The source(s) of the neutrino excess reported by the IceCube Collaboration is unknown. The TANAMI Collaboration recently reported on the multiwavelength emission of six bright, variable blazars which are positionally coincident with two of the most energetic IceCube events. Objects like these are prime candidates to be the source of the highest-energy cosmic rays, and thus of associated neutrino emission. Aims. We present an analysis of neutrino emission from the six blazars using observations with the ANTARES neutrino telescope. Methods. The standard methods of the ANTARES candidate list search are applied to six years of data to search for an excess of muons - and hence their neutrino progenitors - from the directions of the six blazars described by the TANAMI Collaboration, and which are possibly associated with two IceCube events. Monte Carlo simulations of the detector response to both signal and background particle fluxes are used to estimate the sensitivity of this analysis for di erent possible source neutrino spectra. A maximum-likelihood approach, using the reconstructed energies and arrival directions of through-going muons, is used to identify events with properties consistent with a blazar origin. Results. Both blazars predicted to be the most neutrino-bright in the TANAMI sample (1653-329 and 1714-336) have a signal flux fitted by the likelihood analysis corresponding to approximately one event. This observation is consistent with the blazar-origin hypothesis of the IceCube event IC 14 for a broad range of blazar spectra, although an atmospheric origin cannot be excluded. No ANTARES events are observed from any of the other four blazars, including the three associated with IceCube event IC20. This excludes at a 90% confidence level the possibility that this event was produced by these blazars unless the neutrino spectrum is flatter than -2.4.

  10. Leveraging Information Technology. Track VII: Outstanding Applications.

    Science.gov (United States)

    CAUSE, Boulder, CO.

    Eight papers from the 1987 CAUSE conference's Track VII, Outstanding Applications, are presented. They include: "Image Databases in the University" (Reid Kaplan and Gordon Mathieson); "Using Information Technology for Travel Management at the University of Michigan" (Robert E. Russell and John C. Hufziger); "On-Line Access…

  11. 77 FR 64400 - Order of Succession for HUD Region VII

    Science.gov (United States)

    2012-10-19

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [FR-5550-D-10] Order of Succession for HUD Region VII... Offices (Region VII). This Order of Succession supersedes all previous Orders of Succession for HUD Region...). This publication supersedes all previous Orders of Succession for Region VII. Accordingly, the...

  12. Oxidation of triclosan by permanganate (Mn(VII)): importance of ligands and in situ formed manganese oxides.

    Science.gov (United States)

    Jiang, Jin; Pang, Su-Yan; Ma, Jun

    2009-11-01

    Experiments were conducted to examine permanganate (Mn(VII); KMnO(4)) oxidation of the widely used biocide triclosan (one phenolic derivative) in aqueous solution at pH values of 5-9. Under slightly acidic conditions, the reactions displayed autocatalysis, suggesting the catalytic role of in situ formed MnO(2). This was further supported by the promoting effects of the addition of preformed MnO(2) colloids on Mn(VII) oxidations of triclosan and two other selected phenolics (i.e., phenol and 2,4-dichlorophenol), as well as p-nitrophenol which otherwise showed negligible reactivity toward Mn(VII) and MnO(2) colloids, respectively. Surprisingly, phosphate buffer significantly enhanced Mn(VII) oxidation of triclosan, as well as phenol and 2,4-dichlorophenol over a wide pH range. Further, several other selected ligands (i.e., pyrophosphate, EDTA, and humic acid) also exerted oxidation enhancement, supporting a scenario where highly active aqueous manganese intermediates (Mn(INT)(aq)) formed in situ upon Mn(VII) reduction might be stabilized to a certain extent in the presence of ligands and subsequently involved in further oxidation of target phenolics, whereas without stabilizing agents Mn(INT)(aq) autodecomposes or disproportionates spontaneously. The effectiveness of Mn(VII) for the oxidative removal of triclosan in natural water and wastewater was confirmed. Their background matrices were also found to accelerate Mn(VII) oxidation of phenolics.

  13. A Model of Polarisation Rotations in Blazars from Kink Instabilities in Relativistic Jets

    Directory of Open Access Journals (Sweden)

    Krzysztof Nalewajko

    2017-10-01

    Full Text Available This paper presents a simple model of polarisation rotation in optically thin relativistic jets of blazars. The model is based on the development of helical (kink mode of current-driven instability. A possible explanation is suggested for the observational connection between polarisation rotations and optical/gamma-ray flares in blazars, if the current-driven modes are triggered by secular increases of the total jet power. The importance of intrinsic depolarisation in limiting the amplitude of coherent polarisation rotations is demonstrated. The polarisation rotation amplitude is thus very sensitive to the viewing angle, which appears to be inconsistent with the observational estimates of viewing angles in blazars showing polarisation rotations. Overall, there are serious obstacles to explaining large-amplitude polarisation rotations in blazars in terms of current-driven kink modes.

  14. CHARACTERIZING THE OPTICAL VARIABILITY OF BRIGHT BLAZARS: VARIABILITY-BASED SELECTION OF FERMI ACTIVE GALACTIC NUCLEI

    Energy Technology Data Exchange (ETDEWEB)

    Ruan, John J.; Anderson, Scott F.; MacLeod, Chelsea L.; Becker, Andrew C.; Davenport, James R. A.; Ivezic, Zeljko [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Burnett, T. H. [Department of Physics, University of Washington, Seattle, WA 98195-1560 (United States); Kochanek, Christopher S. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Plotkin, Richard M. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Sesar, Branimir [Division of Physics, Mathematics and Astronomy, Caltech, Pasadena, CA 91125 (United States); Stuart, J. Scott, E-mail: jruan@astro.washington.edu [Lincoln Laboratory, Massachusetts Institute of Technology, 244 Wood Street, Lexington, MA 02420-9108 (United States)

    2012-11-20

    We investigate the use of optical photometric variability to select and identify blazars in large-scale time-domain surveys, in part to aid in the identification of blazar counterparts to the {approx}30% of {gamma}-ray sources in the Fermi 2FGL catalog still lacking reliable associations. Using data from the optical LINEAR asteroid survey, we characterize the optical variability of blazars by fitting a damped random walk model to individual light curves with two main model parameters, the characteristic timescales of variability {tau}, and driving amplitudes on short timescales {sigma}-circumflex. Imposing cuts on minimum {tau} and {sigma}-circumflex allows for blazar selection with high efficiency E and completeness C. To test the efficacy of this approach, we apply this method to optically variable LINEAR objects that fall within the several-arcminute error ellipses of {gamma}-ray sources in the Fermi 2FGL catalog. Despite the extreme stellar contamination at the shallow depth of the LINEAR survey, we are able to recover previously associated optical counterparts to Fermi active galactic nuclei with E {>=} 88% and C = 88% in Fermi 95% confidence error ellipses having semimajor axis r < 8'. We find that the suggested radio counterpart to Fermi source 2FGL J1649.6+5238 has optical variability consistent with other {gamma}-ray blazars and is likely to be the {gamma}-ray source. Our results suggest that the variability of the non-thermal jet emission in blazars is stochastic in nature, with unique variability properties due to the effects of relativistic beaming. After correcting for beaming, we estimate that the characteristic timescale of blazar variability is {approx}3 years in the rest frame of the jet, in contrast with the {approx}320 day disk flux timescale observed in quasars. The variability-based selection method presented will be useful for blazar identification in time-domain optical surveys and is also a probe of jet physics.

  15. Steady-state emission of blazars at very high energies

    Energy Technology Data Exchange (ETDEWEB)

    Hoehne-Moench, Daniel

    2010-07-01

    One key scientific program of the MAGIC telescope project is the discovery and detection of blazars. They constitute the most prominent extragalactic source class in the very high energy (VHE) {gamma}-ray regime with 29 out of 34 known objects. Therefore a major part of the available observation time was spent in the last years on high-frequency peaked blazars. The selection criteria were chosen to increase the detection probability. As the X-ray flux is believed to be correlated to the VHE {gamma}-ray flux, only X-ray selected sources with a flux F{sub X}>2 {mu}Jy at 1 keV were considered. To avoid strong attenuation of the -rays in the extragalactic infrared background, the redshift was restricted to values between z<0.15 and z<0.4, depending on the declination of the objects. The latter determines the zenith distance during culmination which should not exceed 30 (for z<0.4) and 45 (for z<0.15), respectively. Between August 2005 and April 2009, a sample of 24 X-ray selected high-frequency peaked blazars has been observed with the MAGIC telescope. Three of them were detected including 1ES 1218+304 being the first high-frequency peaked BL Lacertae object (HBL) to be discovered with MAGIC in VHE {gamma}-rays. One previously detected object was not confirmed as VHE emitter in this campaign by MAGIC. A set of 20 blazars previously not detected is treated more closely in this work. In this campaign, during almost four years {proportional_to}450 hrs or {proportional_to}22% of the available observation time for extragalactic objects were dedicated to investigate the baseline emission of blazars and their broadband spectral properties in this emission state. For the sample of 20 objects in a redshift range of 0.018

  16. Reduction of Tc(VII) by Fe(II) sorbed on Al (hydr)oxides.

    Science.gov (United States)

    Peretyazhko, T; Zachara, J M; Heald, S M; Kukkadapu, R K; Liu, C; Plymale, A E; Resch, C T

    2008-08-01

    Under oxic conditions, Tc exists as the soluble, weakly sorbing pertechnetate [TcO4-] anion. The reduced form of technetium, Tc(IV), is stable in anoxic environments and is sparingly soluble as TcO2 x nH2O(s). Here we investigate the heterogeneous reduction of Tc(VII) by Fe(II) adsorbed on Al (hydr)oxides [diaspore (alpha-AlOOH) and corundum (alpha-Al2O3)]. Experiments were performed to study the kinetics of Tc(VII) reduction, examine changes in Fe surface speciation during Tc(VII) reduction (Mössbauer spectroscopy), and identify the nature of Tc(IV)-containing reaction products (X-ray absorption spectroscopy). We found that Tc(VII) was completely reduced by adsorbed Fe(II) within 11 (diaspore suspension) and 4 days (corundum suspension). Mössbauer measurements revealed thatthe Fe(II) signal became less intense with Tc(VII) reduction and was accompanied by an increase in the intensity of the Fe(III) doublet and magnetically ordered Fe(III) sextet signals. Tc-EXAFS spectroscopy revealed that the final heterogeneous redox product on corundum was similar to Tc(IV) oxyhydroxide, TcO2 x nH2O.

  17. COLLISION-INDUCED MAGNETIC RECONNECTION AND A UNIFIED INTERPRETATION OF POLARIZATION PROPERTIES OF GRBs AND BLAZARS

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Wei; Zhang, Bing [Department of Physics and Astronomy, University of Nevada Las Vegas, Las Vegas, NV 89154 (United States); Zhang, Haocheng; Li, Hui, E-mail: deng@physics.unlv.edu, E-mail: zhang@physics.unlv.edu, E-mail: hli@lanl.gov, E-mail: hz193909@ohio.edu [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2016-04-10

    The jet composition and energy dissipation mechanism of gamma-ray bursts (GRBs) and blazars are fundamental questions that remain not fully understood. One plausible model is to interpret the γ-ray emission of GRBs and optical emission of blazars as synchrotron radiation of electrons accelerated from the collision-induced magnetic dissipation regions in Poynting-flux-dominated jets. The polarization observation is an important and independent information to test this model. Based on our recent 3D relativistic MHD simulations of collision-induced magnetic dissipation of magnetically dominated blobs, here we perform calculations of the polarization properties of the emission in the dissipation region and apply the results to model the polarization observational data of GRB prompt emission and blazar optical emission. We show that the same numerical model with different input parameters can reproduce well the observational data of both GRBs and blazars, especially the 90° polarization angle (PA) change in GRB 100826A and the 180° PA swing in blazar 3C279. This supports a unified model for GRB and blazar jets, suggesting that collision-induced magnetic reconnection is a common physical mechanism to power the relativistic jet emission from events with very different black hole masses.

  18. SYSTEMATIC STUDY OF GAMMA-RAY-BRIGHT BLAZARS WITH OPTICAL POLARIZATION AND GAMMA-RAY VARIABILITY

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Ryosuke; Fukazawa, Yasushi; Kanda, Yuka; Shiki, Kensei; Kawabata, Miho; Nakaoka, Tatsuya; Takaki, Katsutoshi; Takata, Koji; Ui, Takahiro [Department of Physical Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Nalewajko, Krzysztof; Madejski, Greg M. [Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Stanford University, 2575 Sand Hill Road M/S 29, Menlo Park, CA 94025 (United States); Uemura, Makoto; Tanaka, Yasuyuki T.; Kawabata, Koji S.; Akitaya, Hiroshi; Ohsugi, Takashi [Hiroshima Astrophysical Science Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Schinzel, Frank K. [Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131 (United States); Moritani, Yuki [Kavli Institute for the Physics and Mathematics of the Universe (WPI), The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Sasada, Mahito [Institute for Astrophysical Research, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Yamanaka, Masayuki, E-mail: itoh@hep01.hepl.hiroshima-u.ac.jp, E-mail: itoh@hp.phys.titech.ac.jp [Department of Physics, Faculty of Science and Engineering, Konan University, Okamoto, Kobe, Hyogo 658-8501 (Japan); and others

    2016-12-10

    Blazars are highly variable active galactic nuclei that emit radiation at all wavelengths from radio to gamma rays. Polarized radiation from blazars is one key piece of evidence for synchrotron radiation at low energies, and it also varies dramatically. The polarization of blazars is of interest for understanding the origin, confinement, and propagation of jets. However, even though numerous measurements have been performed, the mechanisms behind jet creation, composition, and variability are still debated. We performed simultaneous gamma-ray and optical photopolarimetry observations of 45 blazars between 2008 July and 2014 December to investigate the mechanisms of variability and search for a basic relation between the several subclasses of blazars. We identify a correlation between the maximum degree of optical linear polarization and the gamma-ray luminosity or the ratio of gamma-ray to optical fluxes. Since the maximum polarization degree depends on the condition of the magnetic field (chaotic or ordered), this result implies a systematic difference in the intrinsic alignment of magnetic fields in parsec-scale relativistic jets between different types of blazars (flat-spectrum radio quasars vs. BL Lacs) and consequently between different types of radio galaxies (FR I versus FR II).

  19. OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. V. TNG, KPNO, AND OAN OBSERVATIONS OF BLAZAR CANDIDATES OF UNCERTAIN TYPE IN THE NORTHERN HEMISPHERE

    Energy Technology Data Exchange (ETDEWEB)

    Álvarez Crespo, N.; Massaro, F. [Dipartimento di Fisica, Università degli Studi di Torino, via Pietro Giuria 1, I-10125 Torino (Italy); Masetti, N. [INAF—Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129, Bologna (Italy); Ricci, F.; La Franca, F. [Dipartimento di Matematica e Fisica, Università Roma Tre, via della Vasca Navale 84, I-00146, Roma (Italy); Landoni, M. [INAF-Osservatorio Astronomico di Brera, Via Emilio Bianchi 46, I-23807 Merate (Italy); Patiño-Álvarez, V.; Chavushyan, V.; Torrealba, J. [Instituto Nacional de Astrofisica, Óptica y Electrónica, Apartado Postal 51-216, 72000 Puebla, México (Mexico); D’Abrusco, R.; Paggi, A.; Smith, Howard A. [Harvard—Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Jiménez-Bailón, E. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apdo. Postal 877, Ensenada, 22800 Baja California, México (Mexico); Latronico, L. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Tosti, G. [Dipartimento di Fisica, Università degli Studi di Perugia, I-06123 Perugia (Italy)

    2016-02-15

    The extragalactic γ-ray sky is dominated by emission from blazars, a peculiar class of active galactic nuclei. Many of the γ-ray sources included in the Fermi-Large Area Telescope Third Source catalog (3FGL) are classified as blazar candidates of uncertain type (BCUs) because there are no optical spectra available in the literature to confirm their nature. In 2013, we started a spectroscopic campaign to look for the optical counterparts of the BCUs and of the unidentified γ-ray sources to confirm their blazar nature. Whenever possible we also determine their redshifts. Here, we present the results of the observations carried out in the northern hemisphere in 2013 and 2014 at the Telescopio Nazionale Galileo, Kitt Peak National Observatory, and Observatorio Astronómico Nacional in San Pedro Mártir. In this paper, we describe the optical spectra of 25 sources. We confirmed that all of the 15 BCUs observed in our campaign and included in our sample are blazars and we estimated the redshifts for three of them. In addition, we present the spectra for three sources classified as BL Lacs in the literature but with no optical spectra available to date. We found that one of them is a quasar (QSO) at a redshift of z = 0.208 and the other two are BL Lacs. Moreover, we also present seven new spectra for known blazars listed in the Roma-BZCAT that have an uncertain redshift or are classified as BL Lac candidates. We found that one of them, 5BZB J0724+2621, is a “changing look” blazar. According to the spectrum available in the literature, it was classified as a BL Lac, but in our observation we clearly detected a broad emission line that led us to classify this source as a QSO at z = 1.17.

  20. The VLBA-BU-BLAZAR Multi-Wavelength Monitoring Program

    Directory of Open Access Journals (Sweden)

    Svetlana Jorstad

    2016-10-01

    Full Text Available We describe a multiwavelength program of monitoring of a sample of bright γ-ray blazars, which the Boston University (BU group has being carrying out since June 2007. The program includes monthly monitoring with the Very Long Baseline Array at 43 GHz, optical photometric and polarimetric observations, construction and analysis of UV and X-ray light curves obtained with the Rossi X-ray Timing Explorer (RXTE and Swift satellites, and construction and analysis of γ-ray light curves based on data provided by the Large Area Telescope of the Fermi Gamma-ray Space Telescope. We present general results about the kinematics of parsec-scale radio jets, as well as the connection between γ-ray outbursts and jet events.

  1. VII International Congress of Engineering Physics

    Science.gov (United States)

    2015-01-01

    In the frame of the fortieth anniversary celebration of the Universidad Autónoma Metropolitana and the Physics Engineering career, the Division of Basic Science and Engineering and its Departments organized the "VII International Congress of Physics Engineering". The Congress was held from 24 to 28 November 2014 in Mexico City, Mexico. This congress is the first of its type in Latin America, and because of its international character, it gathers experts on physics engineering from Mexico and all over the globe. Since 1999, this event has shown research, articles, projects, technological developments and vanguard scientists. These activities aim to spread, promote, and share the knowledge of Physics Engineering. The topics of the Congress were: • Renewable energies engineering • Materials technology • Nanotechnology • Medical physics • Educational physics engineering • Nuclear engineering • High precision instrumentation • Atmospheric physics • Optical engineering • Physics history • Acoustics This event integrates lectures on top trending topics with pre-congress workshops, which are given by recognized scientists with an outstanding academic record. The lectures and workshops allow the exchange of experiences, and create and strengthen research networks. The Congress also encourages professional mobility among all universities and research centres from all countries. CIIF2014 Organizing and Editorial Committee Dr. Ernesto Rodrigo Vázquez Cerón Universidad Autónoma Metropolitana - Azcapotzalco ervc@correo.azc.uam.mx Dr. Luis Enrique Noreña Franco Universidad Autónoma Metropolitana - Azcapotzalco lnf@correo.azc.uam.mx Dr. Alberto Rubio Ponce Universidad Autónoma Metropolitana - Azcapotzalco arp@correo.azc.uam.mx Dr. Óscar Olvera Neria Universidad Autónoma Metropolitana - Azcapotzalco oon@correo.azc.uam.mx Professor Jaime Granados Samaniego Universidad Autónoma Metropolitana - Azcapotzalco jgs@correo.azc.uam.mx Dr. Roberto Tito Hern

  2. Observations on the nucleation of ice VII in compressed water

    Science.gov (United States)

    Stafford, Samuel J. P.; Chapman, David J.; Bland, Simon N.; Eakins, Daniel E.

    2017-01-01

    Water can freeze upon multiple shock compression, but the window material determines the pressure of the phase transition. Several plate impact experiments were conducted with liquid targets on a single-stage gas gun, diagnosed simultaneously using photonic doppler velocimetry (PDV) and high speed imaging through the water. The experiments investigated why silica windows instigate freezing above 2.5 GPa whilst sapphire windows do not until 7 GPa. We find that the nucleation of ice occurs on the surfaces of windows and can be affected by the surface coating suggesting the surface energy of fused silica, likely due to hydroxyl groups, encourages nucleation of ice VII crystallites. Aluminium coatings prevent nucleation and sapphire surfaces do not nucleate until approximately 6.5 GPa. This is believed to be the threshold pressure for the homogeneous nucleation of water.

  3. Desain Pembelajaran Materi Belah Ketupat Menggunakan Kain Jumputan Palembang untuk Siswa Kelas VII

    Directory of Open Access Journals (Sweden)

    Fauziyah Fauziyah

    2016-06-01

    Full Text Available Desain pembelajaran materi belah ketupat menggunakan kain Jumputan Palembang untuk siswa kelas VII. Penelitian ini bertujuan untuk melihat bagaimana penggunaan kain Jumputan Palembang dalam membangun pemahaman siswa mengenai belah ketupat. Siswa akan membandingkan luas daerah dua buah kain Jumputan, merancang dan membuat belah ketupat kemudian menggunting serta menyusunnya kembali menjadi suatu bentuk baru, menentukan luas daerah belah ketupat, membandingkan keliling dua buah kain Jumputan dan menentukan keliling belah ketupat. Subjek penelitian ini adalah 30 siswa kelas VII SMP Pusri Palembang. Penelitian ini menggunakan design research yang terdiri dari tiga tahap : preparing for the experiment, experiment in the classroom (pilot experiment dan  teaching experiment, dan retrospective analysis. Pada tahap preparing for the experiment, beberapa aktifitas dibuat menggunakan pendekatan Pendidikan Matematika Realistik Indonesia (PMRI. Hasil dari penelitian menunjukkan kain Jumputan Palembang dapat digunakan sebagai starting point dalam pembelajaran belah ketupat untuk siswa kelas VII SMP.The design learning rhombus using kain Jumputan Palembang for VII grade students. This research aims to investigate how to use Kain Jumputan Palembang to build student’s understanding on rhombus. Students were required to comparing the area of two cloths, designing and making rhombus then reshaping to new shapes, determining the area of rhombus, comparing the perimeter of two cloths and determining the perimeter of rhombus. Subjects were 30 first grade students of SMP Pusri Palembang. The study used a design research method consisting of three stages : preparing for the experiment, experiment in the classroom (pilot experiment and teaching experiment, and retrospective analysis. During the preparing for the experiment stage, instructional activities was designing utilizing of Indonesian Realistic Mathematics Education (PMRI approach. The result of experiments

  4. ENDF/B-VII.1 versus ENDF/B-VII.0: What's Different?

    Energy Technology Data Exchange (ETDEWEB)

    Cullen, D E

    2012-03-20

    Recently the new ENDF/B-VII.1 library was released; this completely replaces the earlier ENDF/B-VII.0 library. One of the first questions we ask about a new library is: What's Different? Here I attempt to at least partially answer this question. I present results in both tabulated form (so you can quickly determine if any evaluations of interest to you have changed), and graphic form (so that you can see how much evaluations have changed and in what energy ranges). For the table I have compared what I refer to as the ENDF neutron data, namely MF=1 through 6. Here I did a character-by-character comparison of the same sections (MF/MT) that appear I both ENDF/B-VII.0 and VII.1; here I found differences in 170 evaluations. For the plots I have only compared the total cross sections for all evaluations that are common to both libraries, and I found that of the 423 evaluations in ENDF/B-VII.1, 120 of these have total cross sections that differ by 1% or more from the evaluation of the same isotope in ENDF/B-VII.0. This should be considered only a preliminary comparison; obviously there can be more subtle important differences that do not effect of total cross sections. Here I present plots comparing the total cross section of these 120 isotopes. The plots are only broad overviews of the total cross sections over their entire energy range. If you have interest in more detailed plots for specific evaluations, you can download the evaluations [1,2] and the PREPRO [3] codes I used to prepare and view the data. This is all I needed to do my comparisons, and is all you should need to do any more detailed comparisons to meet your individual needs.

  5. Polarization and brightness of the blazar S5 0716+714 in 1991-2004

    Science.gov (United States)

    Doroshenko, V. T.; Kiselev, N. N.

    2017-06-01

    We investigate the photometric and polarimetric behavior of the blazar S5 0716+714 based on the observations carried out in 1991-2004 at the 125-cm Crimean Astrophysical Observatory telescope (AZT11) with a photopolarimeter that allows simultaneous polarization and brightness measurements to be made in the U BV RI bands. We also provide the U BV photometry for the blazar obtained in 2000-2009 with a 60-cm telescope at the Crimean Station of the Sternberg Astronomical Institute. The pattern of flux variability and the correlation between the brightness, color, and polarization variations have been investigated. In this time interval the blazar showed a significant brightness and polarization variability similar to noise processes.

  6. CASMO5 JENDL-4.0 and ENDF/B-VII.1beta4 libraries

    International Nuclear Information System (INIS)

    Rhodes, J.; Gheorghiu, N.; Ferrer, R.

    2012-01-01

    This paper details the generation of neutron data libraries for the CASMO5 lattice physics code based on the recently released JENDL-4.0 and ENDF/B-VII.1beta4 nuclear data evaluations. This data represents state-of-the-art nuclear data for late-2011. The key features of the new evaluations are briefly described along with the procedure for processing of this data into CASMO5, 586-energy group neutron data libraries. Finally some CASMO5 results for standard UO 2 and MOX critical experiments for the two new libraries and the current ENDF/B-VII.0 CASMO5 library are presented including the B and W 1810 series, DIMPLE S06A, S06B, TCA reflector criticals with iron plates and the PNL-30-35 MOX criticals. The results show that CASMO5 with the new libraries is performing well for these criticals with a very slight edge in results to the JENDL-4.0 nuclear data evaluation over the ENDF/B-VII.1beta4 evaluation. Work is currently underway to generate a CASMO5 library based on the final ENDF/B-VII.R1 evaluation released Dec. 22, 2011. (authors)

  7. Stochastic modeling of the Fermi/LAT γ-ray blazar variability

    Energy Technology Data Exchange (ETDEWEB)

    Sobolewska, M. A.; Siemiginowska, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kelly, B. C. [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93107 (United States); Nalewajko, K., E-mail: malgosia@camk.edu.pl [JILA, University of Colorado and National Institute of Standards and Technology, 440 UCB, Boulder, CO 80309 (United States)

    2014-05-10

    We study the γ-ray variability of 13 blazars observed with the Fermi/Large Area Telescope (LAT). These blazars have the most complete light curves collected during the first four years of the Fermi sky survey. We model them with the Ornstein-Uhlenbeck (OU) process or a mixture of the OU processes. The OU process has power spectral density (PSD) proportional to 1/f {sup α} with α changing at a characteristic timescale, τ{sub 0}, from 0 (τ >> τ{sub 0}) to 2 (τ << τ{sub 0}). The PSD of the mixed OU process has two characteristic timescales and an additional intermediate region with 0 < α < 2. We show that the OU model provides a good description of the Fermi/LAT light curves of three blazars in our sample. For the first time, we constrain a characteristic γ-ray timescale of variability in two BL Lac sources, 3C 66A and PKS 2155-304 (τ{sub 0} ≅ 25 days and τ{sub 0} ≅ 43 days, respectively, in the observer's frame), which are longer than the soft X-ray timescales detected in blazars and Seyfert galaxies. We find that the mixed OU process approximates the light curves of the remaining 10 blazars better than the OU process. We derive limits on their long and short characteristic timescales, and infer that their Fermi/LAT PSD resemble power-law functions. We constrain the PSD slopes for all but one source in the sample. We find hints for sub-hour Fermi/LAT variability in four flat spectrum radio quasars. We discuss the implications of our results for theoretical models of blazar variability.

  8. THE CONTRIBUTION OF FERMI -2LAC BLAZARS TO DIFFUSE TEV–PEV NEUTRINO FLUX

    Energy Technology Data Exchange (ETDEWEB)

    Aartsen, M. G. [Department of Physics, University of Adelaide, Adelaide, 5005 (Australia); Abraham, K. [Physik-department, Technische Universität München, D-85748 Garching (Germany); Ackermann, M. [DESY, D-15735 Zeuthen (Germany); Adams, J. [Dept. of Physics and Astronomy, University of Canterbury, Private Bag 4800, Christchurch (New Zealand); Aguilar, J. A.; Ansseau, I. [Université Libre de Bruxelles, Science Faculty CP230, B-1050 Brussels (Belgium); Ahlers, M. [Dept. of Physics and Wisconsin IceCube Particle Astrophysics Center, University of Wisconsin, Madison, WI 53706 (United States); Ahrens, M. [Oskar Klein Centre and Dept. of Physics, Stockholm University, SE-10691 Stockholm (Sweden); Altmann, D.; Anton, G. [Erlangen Centre for Astroparticle Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91058 Erlangen (Germany); Andeen, K. [Department of Physics, Marquette University, Milwaukee, WI, 53201 (United States); Anderson, T.; Arlen, T. C. [Dept. of Physics, Pennsylvania State University, University Park, PA 16802 (United States); Archinger, M.; Baum, V. [Institute of Physics, University of Mainz, Staudinger Weg 7, D-55099 Mainz (Germany); Arguelles, C.; Axani, S. [Dept. of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Auffenberg, J. [III. Physikalisches Institut, RWTH Aachen University, D-52056 Aachen (Germany); Bai, X. [Physics Department, South Dakota School of Mines and Technology, Rapid City, SD 57701 (United States); Barwick, S. W., E-mail: thorsten.gluesenkamp@fau.de [Dept. of Physics and Astronomy, University of California, Irvine, CA 92697 (United States); Collaboration: IceCube Collaboration; and others

    2017-01-20

    The recent discovery of a diffuse cosmic neutrino flux extending up to PeV energies raises the question of which astrophysical sources generate this signal. Blazars are one class of extragalactic sources which may produce such high-energy neutrinos. We present a likelihood analysis searching for cumulative neutrino emission from blazars in the 2nd Fermi -LAT AGN catalog (2LAC) using IceCube neutrino data set 2009-12, which was optimized for the detection of individual sources. In contrast to those in previous searches with IceCube, the populations investigated contain up to hundreds of sources, the largest one being the entire blazar sample in the 2LAC catalog. No significant excess is observed, and upper limits for the cumulative flux from these populations are obtained. These constrain the maximum contribution of 2LAC blazars to the observed astrophysical neutrino flux to 27% or less between around 10 TeV and 2 PeV, assuming the equipartition of flavors on Earth and a single power-law spectrum with a spectral index of −2.5. We can still exclude the fact that 2LAC blazars (and their subpopulations) emit more than 50% of the observed neutrinos up to a spectral index as hard as −2.2 in the same energy range. Our result takes into account the fact that the neutrino source count distribution is unknown, and it does not assume strict proportionality of the neutrino flux to the measured 2LAC γ -ray signal for each source. Additionally, we constrain recent models for neutrino emission by blazars.

  9. Long-term monitoring of blazars - the DWARF network

    Science.gov (United States)

    Backes, Michael; Biland, Adrian; Boller, Andrea; Braun, Isabel; Bretz, Thomas; Commichau, Sebastian; Commichau, Volker; Dorner, Daniela; von Gunten, Hanspeter; Gendotti, Adamo; Grimm, Oliver; Hildebrand, Dorothée; Horisberger, Urs; Krähenbühl, Thomas; Kranich, Daniel; Lustermann, Werner; Mannheim, Karl; Neise, Dominik; Pauss, Felicitas; Renker, Dieter; Rhode, Wolfgang; Rissi, Michael; Rollke, Sebastian; Röser, Ulf; Stark, Luisa Sabrina; Stucki, Jean-Pierre; Viertel, Gert; Vogler, Patrick; Weitzel, Quirin

    The variability of the very high energy (VHE) emission from blazars seems to be connected with the feeding and propagation of relativistic jets and with their origin in supermassive black hole binaries. The key to understanding their properties is measuring well-sampled gamma-ray lightcurves, revealing the typical source behavior unbiased by prior knowledge from other wavebands. Using ground-based gamma-ray observatories with exposures limited by dark-time, a global network of several telescopes is needed to carry out fulltime measurements. Obviously, such observations are time-consuming and, therefore, cannot be carried out with the present state of the art instruments. The DWARF telescope on the Canary Island of La Palma is dedicated to monitoring observations. It is currently being set up, employing a costefficient and robotic design. Part of this project is the future construction of a distributed network of small telescopes. The physical motivation of VHE long-term monitoring will be outlined in detail and the perspective for a network for 24/7 observations will be presented.

  10. Sexual Harassment: Finding a Cause of Action Under Title VII.

    Science.gov (United States)

    Seymour, William C.

    1979-01-01

    Examines whether the prohibition against sex discrimination in Title VII of the Civil Rights Act of 1964 includes a prohibition against sexual harassment and the evolving theory in the federal court system that permits the plaintiff to include the corporate employer in her Title VII claim. (Author/IRT)

  11. Re(VII) and Tc(VII) trioxo complexes stabilized by tridentate ligands and their potential use as radiopharmaceuticals

    NARCIS (Netherlands)

    Hahn, Eva M.; Casini, Angela; Kuehn, Fritz E.

    2014-01-01

    Tc(VII) and Re(VII) trioxo complexes are currently arousing interest because of their potential use as radiopharmaceuticals due to their hydrophilic character and stability in a biological environment. The radioactive isotopes Tc-99m and Re-188 are readily obtained from commercially available

  12. "Viies aastaaeg" kui voolav ruum / Veronika Valk

    Index Scriptorium Estoniae

    Valk, Veronika, 1976-

    2015-01-01

    Arhitektuurivõistluse eesmärk oli leida Suure-Jaani tervisekeskusele sobivaim lahendus. 2015. aasta sügisel toimunud võistlusele laekus 12 tööd, millest hankija esitatud tingimusele vastas 11. Võitjaks osutus Arhitekt Musta ja Novarci ühistööna valminud kavand "Viies aastaaeg" (autorid: Ott Alver, Alvin Järving, Mari Rass, Gert Guriev, Liina Liis Pihu, Märten Peterson ja Reino Rass). Teise koha sai töö "Polüfoonia" (autorid: Urmo Mets, Kaur Talpsep, Kristiina Aasvee ja Lauri Eltermaa Kauss Arhitektuurist). Kolmanda koha sai töö "Akord" (autorid: Joel Kopli, Koit Ojaliiv ja Rene Sauemägi Amhold/Kuust)

  13. Methods for the Quasi-Periodic Variability Analysis in Blazars Y. Liu ...

    Indian Academy of Sciences (India)

    the variability analysis in blazars in optical and radio bands, to search for possible quasi-periodic signals. 2. Power spectral density (PSD). In statistical signal processing and physics, the power spectral density (PSD) is a positive real function of a frequency variable associated with a stationary stochas- tic process. Intuitively ...

  14. Search for neutrino emission from gamma-ray flaring blazars with the ANTARES telescope

    NARCIS (Netherlands)

    Adrian-Martinez, S.; Al Samarai, I.; Albert, A.; Andre, M.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Astraatmadja, T.; Aubert, J.J.; Baret, B.; Basa, S.; Bertin, V.; Biagi, S.; Bigongiari, C.; Bogazzi, C.; Bou-Cabo, M.; Bouhou, B.; Bouwhuis, M.C.; Brunner, J.; Busto, J.; Camarena, F.; Capone, A.; Carloganu, C.; Carminati, G.; Carr, J.; Cecchini, S.; Charif, Z.; Charvis, P.; Chiarusi, T.; Circella, M.; Core, L.; Costantini, H.; Coyle, P.; Creusot, A.; Curtil, C.; De Bonis, G.; Decowski, M.P.; Dekeyser, I.; Deschamps, A.; Distefano, C.; Donzaud, C.; Dornic, D.; Dorosti, Q.; Drouhin, D.; Eberl, T.; Emanuele, U.; Enzenhofer, A.; Ernenwein, J.P.; Escoffier, S.; Fehn, K.; Fermani, P.; Ferri, M.; Ferry, S.; Flaminio, V.; Folger, F.; Fritsch, U.; Fuda, J.L.; Galata, S.; Gay, P.; Geyer, K.; Giacomelli, G.; Giordano, V.; Gomez-Gonzalez, J.P.; Graft, K.; Guillard, G.; Halladjian, G.; Hallewell, G.; van Haren, H.; Hartman, J.; Heijboer, A.J.; Hello, Y.; Hernandez-Rey, J.J.; Herold, B.; Hoessl, J.; Hsu, C.C.; De Jong, M.; Kadler, M.; Kalekin, O.; Kappes, A.; Katz, U.; Kavatsyuk, O.; Kooijman, P.; Kopper, C.; Kouchner, A.; Kreykenbohm, I.; Kulikovskiy, V.; Lahmann, R.; Lambard, G.; Larosa, G.; Lattuada, D.; Lefevre, D.; Lim, G.; Lo Presti, D.; Loehner, H.; Loucatos, S.; Louis, F.; Mangano, S.; Marcelin, M.; Margiotta, A.; Martinez-Mora, J.A.; Meli, A.; Montaruli, T.; Morganti, N.; Moscoso, L.; Motz, H.; Neff, M.; Nezri, E.; Palioselitis, D.; Pavalas, G.E.; Payet, K.; Payre, P.; Petrovic, J.; Piattelli, P.; Picot-Clemente, N.; Popa, V.; Pradier, T.; Presani, E.; Racca, C.; Reed, C.; Riccobene, G.; Richardt, C.; Richter, R.; Riviere, C.; Robert, A.; Roensch, K.; Rostovtsev, A.; Ruiz-Rivas, J.; Rujoiu, M.; Russo, G.V.; Salesa, F.; Samtleben, D.F.E.; Sapienza, P.; Schock, F.; Schuller, J.P.; Schussler, F.; Seitz, T.; Shanidze, R.; Simeone, F.; Spies, A.; Spurio, M.; Steijger, J.J.M.; Stolarczyk, T.; Sanchez-Losa, A.; Taiuti, M.; Tamburini, C.; Toscano, S.; Vallage, B.; Vallee, C.; Van Elewyck, V.; Vannoni, G.; Vecchi, M.; Vernin, P.; Visser, E.; Wagner, S.; Wijnker, G.; Wilms, J.; de Wolf, E.; Yepes, H.; Zaborov, D.; Zornoza, J.D.; Zuniga, J.

    2012-01-01

    The ANTARES telescope is well-suited to detect neutrinos produced in astrophysical transient sources as it can observe a full hemisphere of the sky at all times with a high duty cycle. Radio-loud active galactic nuclei with jets pointing almost directly towards the observer, the so-called blazars,

  15. ANTARES constrains a blazar origin of two IceCube PeV neutrino events - Letter

    NARCIS (Netherlands)

    Adrián-Martínez, S.; et al., [Unknown; Bruijn, R.; Kooijman, P.; Palioselitis, D.; de Wolf, E.

    2015-01-01

    Context. The source(s) of the neutrino excess reported by the IceCube Collaboration is unknown. The TANAMI Collaboration recently reported on the multiwavelength emission of six bright, variable blazars which are positionally coincident with two of the most energetic IceCube events. Objects like

  16. Neutrinos and Ultra-high-energy Cosmic-ray Nuclei from Blazars

    Science.gov (United States)

    Rodrigues, Xavier; Fedynitch, Anatoli; Gao, Shan; Boncioli, Denise; Winter, Walter

    2018-02-01

    We discuss the production of ultra-high-energy cosmic-ray (UHECR) nuclei and neutrinos from blazars. We compute the nuclear cascade in the jet for both BL Lac objects and flat-spectrum radio quasars (FSRQs), and in the ambient radiation zones for FSRQs as well. By modeling representative spectral energy distributions along the blazar sequence, two distinct regimes are identified, which we call “nuclear survival” (typically found in low-luminosity BL Lacs) and “nuclear cascade” (typically found in high-luminosity FSRQs). We quantify how the neutrino and cosmic-ray (CR) emission efficiencies evolve over the blazar sequence, and we demonstrate that neutrinos and CRs come from very different object classes. For example, high-frequency-peaked BL Lacs (HBLs) tend to produce CRs, and high-luminosity FSRQs are the more efficient neutrino emitters. This conclusion does not depend on the CR escape mechanism, for which we discuss two alternatives (diffusive and advective escape). Finally, the neutrino spectrum from blazars is shown to significantly depend on the injection composition into the jet, especially in the nuclear cascade case: Injection compositions heavier than protons lead to reduced neutrino production at the peak, which moves at the same time to lower energies. Thus, these sources will exhibit better compatibility with the observed IceCube and UHECR data.

  17. Multi-Wavelength Variability Properties of Fermi Blazar S5 0716+ ...

    Indian Academy of Sciences (India)

    2Key Laboratory for the Structure and Evolution of Celestial Objects, Yunnan Astronomical. Observatory, Chinese ... Blazars, including flat spectrum radio quasars and BL Lacertae objects are radio- loud active galactic ... interpreted by the relativistic jet oriented close to the line-of-sight (Blandford & Rees. 1978). But the ...

  18. Relativistic Beaming Effect in Fermi Blazars J. H. Fan1,2,∗ , D ...

    Indian Academy of Sciences (India)

    However, all of the discus- sions are based on the lower energetic bands, the radio Doppler factor, the radio polarization, the brightness temperature, and the superluminal motions. It is known that the Doppler factors are important in the discussion of blazars. So, if one can determine the Doppler factor in the γ-ray region, ...

  19. Models for High-Energy Radiation from Blazars G. E. Romero1 ...

    Indian Academy of Sciences (India)

    Key words. Blazars—radiation mechanisms: non-thermal—jets. 1. Introduction. The unification paradigm for Active Galactic Nuclei (AGN) suggests that different observational properties of these objects are basically due to the different angles of observations (e.g., Urry & Padovani 1995). Blazars are the AGN in which the jet.

  20. J1026+2542 : Proper motion in a blazar jet at z=5.27

    NARCIS (Netherlands)

    Frey, S.; Paragi, Z.; Fogasy, J.O.; Gurvits, L.

    2014-01-01

    The radio-loud AGN J1026+2542 has recently been classified as the second most distant blazar, based on its broad-band spectral energy distribution and X-ray spectrum. The source with a prominent one-sided jet extending to at least ?20 mas was earlier observed with the VLBA at 5 GHz in January 2006.

  1. Models for Very Rapid High-Energy γ-Ray Variability in Blazars G. E. ...

    Indian Academy of Sciences (India)

    Blazars display rapid variability across the entire electromagnetic spectrum. Vari- ability at high energies on timescales of a few minutes has been observed for some of them, such as PKS 2155−304 (e.g., Aharonian et al. 2007). This discovery has led to the formulation of a large variety of models for non-thermal variability in ...

  2. Multi-Frequency Observations of Gamma-Ray Blazar 1633+382 SG ...

    Indian Academy of Sciences (India)

    Gamma-rays—quasars: 1633+382(4C+38.41)—radio jets— polarization. 1. Introduction. Blazars are the most numerous objects in the γ-ray sky (Abdo et al. 2010). They show dramatic variability across the electromagnetic spectrum (e.g., Jorstad et al. 2010; Marscher et al. 2010). Both these properties (strong γ-ray emission.

  3. Models for High-Energy Radiation from Blazars G. E. Romero1 ...

    Indian Academy of Sciences (India)

    Abstract. We discuss on the modelling of blazar jets as emitters of multiwavelength radiation with the implementation of a lepto-hadronic treatment. Assuming that injection of non-thermal electrons and protons can take place at the base of the jet, the stationary particle distributions can be found using an inhomogeneous ...

  4. γ-Ray Emission from the Extreme Blazar 1ES 0229+200 J. Li, T ...

    Indian Academy of Sciences (India)

    Abstract. Based on the traditional Synchrotron Self-Compton (SSC) model, we consider a secondary γ-ray emission component to an extreme blazar 1ES 0229 + 200 for the multiwavelength radiation. By assuming a suitable electron spectra and Inter-Galactic Magnetic Field (IGMF), we obtained excellent fits to observed ...

  5. Estimating Black Hole Masses of Blazars Xue-Bing Wu1,∗ , FK Liu1 ...

    Indian Academy of Sciences (India)

    only for nearby sources. We have to seek other methods for most blazars because the velocity dispersions of their host galaxies are too difficult to be measured. In this paper, we report our progress on estimating the black hole masses of radio- loud AGNs using a new BLR size–Hβ emission line luminosity relation and the.

  6. Spectral Index Changes with Brightness for γ-Ray Loud Blazars J. H. ...

    Indian Academy of Sciences (India)

    spectral index changes depending on γ-ray brightness is obtained. ... the γ-ray band. Key words. Active galactic nuclei (AGN): blazars: γ-ray emission: spectral index. 1. Introduction. Generally, the spectrum of one source changes with its .... Pearl River Scholar Funded Scheme (GDUPS) (2009), Yangcheng Scholar Funded.

  7. Variability of Spectral Energy Distribution of Blazar S5 0716+714 B ...

    Indian Academy of Sciences (India)

    Abstract. The emission from blazars is known to be variable at all wave- lengths. The flux variability is often accompanied by spectral changes. Spectral energy distribution (SED) changes must be associated with changes in the spectra of emitting electrons and/or the physical param- eters of the jet. Meaningful modeling of ...

  8. Position Angle Changes of Inner-Jets in a Sample of Blazars Ligong ...

    Indian Academy of Sciences (India)

    Key words. Active galactic nuclei: blazars—radio continuum: variability— γ-ray: Fermi-LAT. 1. Model-fit and statistical analysis. We compiled a sample of 104 ... Position Angle Changes of Inner-Jets of Blazars. 395. Table 1. Statistics of correlations of IF vs. PA in G1. (1). (2). (3). (4). Class. N. Positive corr. Negative corr.

  9. γ-Rays Radiation of High Redshift Fermi Blazars WG Liu1, SH Fu2 ...

    Indian Academy of Sciences (India)

    γ-Rays Radiation of High Redshift Fermi Blazars. W. G. Liu1, S. H. Fu2, X. Zhang1, L. Ma1,∗. , Y. B. Li1 & D. R. Xiong1. 1Department of Physics, Yunnan Normal University, Kunming 650500, China. 2Yunnan Entry-Exit Inspection and Quarantine Bureau, Kunming 650228, China. ∗ e-mail: astromali@126.com. Abstract.

  10. Spectral Index Changes with Brightness for γ-Ray Loud Blazars J. H. ...

    Indian Academy of Sciences (India)

    spectral index changes depending on γ-ray brightness is obtained. ... the γ-ray band. Key words. Active galactic nuclei (AGN): blazars: γ-ray emission: spectral index. 1. Introduction. Generally, the spectrum of one source changes with its .... China (NSFC 11173009, NSFC 11203007), the research fund of Hunan University.

  11. Multi-Wavelength Variability Properties of Fermi Blazar S5 0716+ ...

    Indian Academy of Sciences (India)

    interpreted by the relativistic jet oriented close to the line-of-sight (Blandford & Rees. 1978). But the radiation process of blazars is still an open question. Researching .... Innovation Promotion Association, CAS. References. Abdo, A. A. et al. 2011, ApJ, 730, 101. Aller, M. F., Aller, H. D., Hughes, P. A., Latimer, G. A. 1999, ApJ, ...

  12. Position Angle Changes of Inner-Jets in a Sample of Blazars Ligong ...

    Indian Academy of Sciences (India)

    Position Angle Changes of Inner-Jets in a Sample of Blazars. Ligong Mi1,3,∗ & Xiang Liu1,2. 1Xinjiang Astronomical Observatory, CAS, 150 Science 1-Street, Urumqi 830011,. People's Republic of China. 2Key Laboratory of Radio Astronomy, CAS, Nanjing 210008, People's Republic of China. 3University of Chinese ...

  13. Comparisons of Jet Properties between GeV Radio Galaxies and Blazars

    Science.gov (United States)

    Xue, Zi-Wei; Zhang, Jin; Cui, Wei; Liang, En-Wei; Zhang, Shuang-Nan

    2017-09-01

    We compile a sample of spectral energy distributions (SEDs) of 12 GeV radio galaxies (RGs), including eight FR I RGs and four FR II RGs. These SEDs can be represented with the one-zone leptonic model. No significant unification, as expected in the unification model, is found for the derived jet parameters between FR I RGs and BL Lacertae objects (BL Lacs) and between FR II RGs and flat spectrum radio quasars (FSRQs). However, on average FR I RGs have a larger {γ }{{b}} (break Lorentz factor of electrons) and lower B (magnetic field strength) than FR II RGs, analogous to the differences between BL Lacs and FSRQs. The derived Doppler factors (δ) of RGs are on average smaller than those of blazars, which is consistent with the unification model such that RGs are the misaligned parent populations of blazars with smaller δ. On the basis of jet parameters from SED fits, we calculate their jet powers and the powers carried by each component, and compare their jet compositions and radiation efficiencies with blazars. Most of the RG jets may be dominated by particles, like BL Lacs, not FSRQs. However, the jets of RGs with higher radiation efficiencies tend to have higher jet magnetization. A strong anticorrelation between synchrotron peak frequency and jet power is observed for GeV RGs and blazars in both the observer and co-moving frames, indicating that the “sequence” behavior among blazars, together with the GeV RGs, may be intrinsically dominated by jet power.

  14. VLA Radio Observations of the blazar TXS 0506+056 associated with the IceCube-170922A neutrino event

    Science.gov (United States)

    Tetarenko, A. J.; Sivakoff, G. R.; Kimball, A. E.; Miller-Jones, J. C. A.

    2017-10-01

    We report VLA radio observations of the blazar TXS 0506+056, following its identification as the potential astrophysical origin of the extremely high energy neutrino event IceCube-170922A (GCN #21916).

  15. Free energy models for ice VII and liquid water derived from pressure, entropy, and heat capacity relations.

    Science.gov (United States)

    Myint, Philip C; Benedict, Lorin X; Belof, Jonathan L

    2017-08-28

    We present equations of state relevant to conditions encountered in ramp and multiple-shock compression experiments of water. These experiments compress water from ambient conditions to pressures as high as about 14 GPa and temperatures of up to several hundreds of Kelvin. Water may freeze into ice VII during this process. Although there are several studies on the thermodynamic properties of ice VII, an accurate and analytic free energy model from which all other properties may be derived in a thermodynamically consistent manner has not been previously determined. We have developed such a free energy model for ice VII that is calibrated with pressure-volume-temperature measurements and melt curve data. Furthermore, we show that liquid water in the pressure and temperature range of interest is well-represented by a simple Mie-Grüneisen equation of state. Our liquid water and ice VII equations of state are validated by comparing to sound speed and Hugoniot data. Although they are targeted towards ramp and multiple-shock compression experiments, we demonstrate that our equations of state also behave reasonably well at pressures and temperatures that lie somewhat beyond those found in the experiments.

  16. ROXA: a new multi-frequency large sample of blazars selected with SDSS and 2dF optical spectroscopy

    Science.gov (United States)

    Turriziani, S.; Cavazzuti, E.; Giommi, P.

    2007-09-01

    Context: Although blazars make of a small fraction of the overall AGN population, they are expected to be the dominant population of extragalactic sources in the hard X-ray and gamma-ray bands and have been shown to be the largest contaminant of CMB fluctuation maps. So far the number of known blazars is of the order of several hundreds, but the forthcoming AGILE, GLAST and Planck space observatories will detect several thousand objects of this type. Aims: In preparation for these missions it is necessary to identify new samples of blazars to study their multi-frequency characteristics and statistical properties. Methods: We compiled a sample of objects with blazar-like properties via a cross-correlation between large radio (NVSS, ATCAPMN) and X-ray surveys (RASS) using the SDSS-DR4 and 2dF survey data to spectroscopically identify our candidates and test the validity of the selection method. Results: We present the Radio-Optical-X-ray catalog built at ASDC (ROXA), a list of 816 objects among which 510 are confirmed blazars. Only 19% of the candidates were certain non-blazars, demonstrating the high efficiency of our selection method. Conclusions: Our catalog includes 173 new blazar identifications, or about 10% of all presently known blazars. The relatively high flux threshold in the X-ray energy band (given by the RASS survey) preferentially selects objects with high f_x/fr ratio leading to the discovery of new High Energy Peaked BL Lac (HBLs). Our catalog therefore includes many new potential targets for GeV-TeV observations. The catalog is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/472/699

  17. Proceedings of the 3rd workshop on Wendelstein VII-X

    International Nuclear Information System (INIS)

    Rau, F.

    1989-11-01

    This report presents the major part of the information given at the 3rd Workshop on Wendelstein VII-X, held at Schloss Ringberg near Lake Tegernsee, 26-30 June 1989. A number of 9 papers by members of the INTERATOM study group has been summarized. The ongoing work of the development of W VII-X is concentrated on a small number of Helias configurations with five field periods, in order to define their coil systems and the attainable parameter range. This effort aims at a simultaneous realization of the desired numbers of plasma aspect ratio, stability-β, transport, improvement in bootstrap current, etc., in order to arrive at a 'reference configuration' for this experiment. (orig.)

  18. Immobilization of 99-Technetium (VII) by Fe(II)-Goethite and Limited Reoxidation

    Energy Technology Data Exchange (ETDEWEB)

    W Um; H Chang; J Icenhower; W Lukens; R Serne; N Qafoku; J Westsik Jr.; E Buck; S Smith

    2011-12-31

    During the nuclear waste vitrification process volatilized {sup 99}Tc will be trapped by melter off-gas scrubbers and then washed out into caustic solutions, and plans are currently being contemplated for the disposal of such secondary waste. Solutions containing pertechnetate [{sup 99}Tc(VII)O{sub 4}{sup -}] were mixed with precipitating goethite and dissolved Fe(II) to determine if an iron (oxy)hydroxide-based waste form can reduce Tc(VII) and isolate Tc(IV) from oxygen. The results of these experiments demonstrate that Fe(II) with goethite efficiently catalyzes the reduction of technetium in deionized water and complex solutions that mimic the chemical composition of caustic waste scrubber media. Identification of the phases, goethite + magnetite, was performed using XRD, SEM and TEM methods. Analyses of the Tc-bearing solid products by XAFS indicate that all of the Tc(VII) was reduced to Tc(IV) and that the latter is incorporated into goethite or magnetite as octahedral Tc(IV). Batch dissolution experiments, conducted under ambient oxidizing conditions for more than 180 days, demonstrated a very limited release of Tc to solution (2-7 {micro}g Tc/g solid). Incorporation of Tc(IV) into the goethite lattice thus provides significant advantages for limiting reoxidation and curtailing release of Tc disposed in nuclear waste repositories.

  19. 29 CFR 1601.91 - Request for title VII interpretation or opinion.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Request for title VII interpretation or opinion. 1601.91... PROCEDURAL REGULATIONS Title VII Interpretations and Opinions by the Commission § 1601.91 Request for title VII interpretation or opinion. Any interested person desiring a written title VII interpretation or...

  20. TEH võrgustik - viis aastat Eestis / Marika Kusnets

    Index Scriptorium Estoniae

    Kusnets, Marika

    2005-01-01

    Eestis on tervist edendavate haiglate (TEH) võrgustik tegutsenud juba viis aastat, sellega on liitunud 22 haiglat. Tänavust konverentsi peeti teemal "Tervise edendamine ja kvaliteedi tagamine haiglas: standardid ja praktika"

  1. Compression Freezing Kinetics of Water to Ice VII

    Science.gov (United States)

    Gleason, A. E.; Bolme, C. A.; Galtier, E.; Lee, H. J.; Granados, E.; Dolan, D. H.; Seagle, C. T.; Ao, T.; Ali, S.; Lazicki, A.; Swift, D.; Celliers, P.; Mao, W. L.

    2017-07-01

    Time-resolved x-ray diffraction (XRD) of compressed liquid water shows transformation to ice VII in 6 nsec, revealing crystallization rather than amorphous solidification during compression freezing. Application of classical nucleation theory indicates heterogeneous nucleation and one-dimensional (e.g., needlelike) growth. These first XRD data demonstrate rapid growth kinetics of ice VII with implications for fundamental physics of diffusion-mediated crystallization and thermodynamic modeling of collision or impact events on ice-rich planetary bodies.

  2. Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect

    NARCIS (Netherlands)

    Mathijssen, N.C.J.; Masereeuw, R.; Holme, P.A.; Kraaij, M.G.J. van; Laros, B.A.P.; Peyvandi, F.; Heerde, W.L. van

    2013-01-01

    INTRODUCTION: Prophylaxis with plasma-derived or recombinant activated factor VII is beneficial in severe factor VII deficiency. To understand why prophylactic treatment with both products is efficacious, we conducted a pharmacokinetic study. MATERIALS AND METHODS: Ten factor VII deficient patients

  3. Experimental evidence for competitive growth advantage of genotype VII over VI: implications for foot-and-mouth disease virus serotype A genotype turnover in nature.

    Science.gov (United States)

    Mohapatra, J K; Subramaniam, S; Singh, N K; Sanyal, A; Pattnaik, B

    2012-04-01

    In India, systematic genotype replacement has been observed for serotype A foot-and-mouth disease virus. After a decade of co-circulation of genotypes VI and VII, genotype VII emerged as the single dominant genotype since 2001. To derive possible explanations for such epochal evolution dynamics, in vitro intergenotype growth competition experiments involving both co- and superinfection regimes were conducted. Coinfection of BHK-21 cells demonstrated abrupt loss in the genotype VI viral load with commensurate increase in the load of genotype VII as measured by the genotype differentiating ELISA, RT-PCR and real-time RT-PCR. The superinfection dynamics was shaped by temporal spacing of infection, where the invading genotype VII took more number of passages than coinfection to eventually overtake the resident genotype VI. It was speculated that such superior replicative fitness of genotype VII could have been a possible factor for the ultimate dominance of genotype VII in nature. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. 3 mm GMVA Observations of Total and Polarized Emission from Blazar and Radio Galaxy Core Regions

    Directory of Open Access Journals (Sweden)

    Carolina Casadio

    2017-10-01

    Full Text Available We present total and linearly polarized 3 mm Global mm-VLBI Array (GMVA; mm-VLBI: Very Long Baseline Interferometry observations at millimetre wavelengths images of a sample of blazars and radio galaxies from the VLBA-BU-BLAZAR 7 mm monitoring program designed to probe the innermost regions of active galactic nuclei (AGN jets and locate the sites of gamma-ray emission observed by the Fermi-LAT. The lower opacity at 3 mm and improved angular resolution—on the order of 50 microarcseconds—allow us to distinguish features in the jet not visible in the 7 mm VLBA data. We also compare two different methods used for the calibration of instrumental polarisation and we analyze the resulting images for some of the sources in the sample.

  5. Broad Band Spectral Index TeV Blazars Detected by Fermi LAT ...

    Indian Academy of Sciences (India)

    Abstract. We collected the radio, K-band, optical, X-ray, and γ-ray data for 35 TeV blazars detected by Fermi LAT and studied the possible corre- lation between different broad band spectral indices (αr.o, αr.x, αir.o, αir.x, αo.γ , αx.γ ) in all states (average/high/low). Based on our results, we sug- gested that the seed photons ...

  6. The WEBT Campaign on the Blazar 3C 279 in 2006

    Czech Academy of Sciences Publication Activity Database

    Böttcher, M.; Basu, S.; Joshi, M.; Villata, M.; Arai, A.; Aryan, N.; Asfandiyarov, I. M.; Bach, U.; Bachev, R.; Berdyugin, A.; Blažek, Martin; Buemi, C.S.; Castro-Tirado, A.J.; de Ugarte Postigo, A.; Frasca, A.; Fuhrmann, L.; Hagen-Thorn, V.A.; Henson, G.; Hovatta, T.; Hudec, René; Ibrahimov, M.A.; Ishii, Y.; Ivanidze, R.; Jelínek, M.; Kamada, M.; Kapanadze, B.; Katsuura, M.; Kotaka, D.; Kovalev, Y.Y.; Kovalev, Yu.A.; Kubánek, Petr; Kurosaki, M.; Kurtanidze, O.M.; Lähteenmäki, A.; Lanteri, L.; Larionov, V.M.; Larionova, L.; Lee, C.-U.; Leto, P.; Lindfors, E.; Marilli, E.; Marshall, K.; Miller, H.R.; Mingaliev, M.G.; Mirabal, N.; Mizoguchi, S.; Nakamura, K.; Nieppola, E.; Nikolashvili, M.G.; Nilsson, K.; Nishiyama, S.; Ohlert, J.M.; Osterman, M.A.; Pak, S.; Pasanen, M.; Peters, C.S.; Pursimo, T.; Raiteri, C.M.; Robertson, J.; Robertson, T.; Ryle, W.T.; Sadakane, K.; Sadun, A.C.; Sigua, L.A.; Sohn, B.-W.; Strigachev, A.; Sumitomo, N.; Takalo, L.O.; Tamesue, Y.; Tanaka, K.; Thorstensen, J.R.; Tosti, G.; Trigilio, C.; Umana, G.; Vennes, S.; Vítek, S.; Volvach, A.; Webb, J.; Yamanaka, M.; Yim, S.-H.

    2007-01-01

    Roč. 670, č. 2 (2007), s. 968-977 ISSN 0004-637X Grant - others:EU(XE) ESA-PECS project No. 98023 Institutional research plan: CEZ:AV0Z10030501 Source of funding: V - iné verejné zdroje Keywords : blazars * active galactic nuclei Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 6.405, year: 2007

  7. The Evolution of Swift/BAT blazars and the origin of the MeV background

    Energy Technology Data Exchange (ETDEWEB)

    Ajello, M.; /SLAC /KIPAC, Menlo Park; Costamante, L.; /Stanford U., HEPL /KIPAC, Menlo Park; Sambruna, R.M.; Gehrels, N.; /NASA, Goddard; Chiang, J.; /SLAC /KIPAC, Menlo Park; Rau, A.; /Caltech; Escala, A.; /SLAC /KIPAC, Menlo Park /Cerro Calan Observ.; Greiner, J.; /Garching, Max Planck Inst., MPE; Tueller, J.; /NASA, Goddard; Wall, J.V.; /British Columbia U.; Mushotzky, R.F.; /NASA, Goddard

    2009-10-17

    We use 3 years of data from the Swift/BAT survey to select a complete sample of X-ray blazars above 15 keV. This sample comprises 26 Flat-Spectrum Radio Quasars (FSRQs) and 12 BL Lac objects detected over a redshift range of 0.03 < z < 4.0. We use this sample to determine, for the first time in the 15-55 keV band, the evolution of blazars. We find that, contrary to the Seyfert-like AGNs detected by BAT, the population of blazars shows strong positive evolution. This evolution is comparable to the evolution of luminous optical QSOs and luminous X-ray selected AGNs. We also find evidence for an epoch-dependence of the evolution as determined previously for radio-quiet AGNs. We interpret both these findings as a strong link between accretion and jet activity. In our sample, the FSRQs evolve strongly, while our best-fit shows that BL Lacs might not evolve at all. The blazar population accounts for 10-20% (depending on the evolution of the BL Lacs) of the Cosmic X-ray background (CXB) in the 15-55 keV band. We find that FSRQs can explain the entire CXB emission for energies above 500 keV solving the mystery of the generation of the MeV background. The evolution of luminous FSRQs shows a peak in redshift (z{sub c} = 4.3 {+-} 0.5) which is larger than the one observed in QSOs and X-ray selected AGNs. We argue that FSRQs can be used as tracers of massive elliptical galaxies in the early Universe.

  8. Relation between X-Ray and γ-Ray Emissions for Fermi Blazars ...

    Indian Academy of Sciences (India)

    Abstract. Using γ-ray band data detected by Fermi Large Area Tele- scope (LAT) and X-ray band data for 78 blazars, we find a medium cor- relation between X-ray and γ-ray fluxes in the average state. A medium anticorrelation is also found between X-ray (1 KeV) mean spectral index αx and γ-ray mean spectral index αγ for ...

  9. The Electrostatic Instability for Realistic Pair Distributions in Blazar/EBL Cascades

    Science.gov (United States)

    Vafin, S.; Rafighi, I.; Pohl, M.; Niemiec, J.

    2018-04-01

    This work revisits the electrostatic instability for blazar-induced pair beams propagating through the intergalactic medium (IGM) using linear analysis and PIC simulations. We study the impact of the realistic distribution function of pairs resulting from the interaction of high-energy gamma-rays with the extragalactic background light. We present analytical and numerical calculations of the linear growth rate of the instability for the arbitrary orientation of wave vectors. Our results explicitly demonstrate that the finite angular spread of the beam dramatically affects the growth rate of the waves, leading to the fastest growth for wave vectors quasi-parallel to the beam direction and a growth rate at oblique directions that is only a factor of 2–4 smaller compared to the maximum. To study the nonlinear beam relaxation, we performed PIC simulations that take into account a realistic wide-energy distribution of beam particles. The parameters of the simulated beam-plasma system provide an adequate physical picture that can be extrapolated to realistic blazar-induced pairs. In our simulations, the beam looses only 1% of its energy, and we analytically estimate that the beam would lose its total energy over about 100 simulation times. An analytical scaling is then used to extrapolate the parameters of realistic blazar-induced pair beams. We find that they can dissipate their energy slightly faster by the electrostatic instability than through inverse-Compton scattering. The uncertainties arising from, e.g., details of the primary gamma-ray spectrum are too large to make firm statements for individual blazars, and an analysis based on their specific properties is required.

  10. UV and X-ray Variability of Blazars Alok C. Gupta

    Indian Academy of Sciences (India)

    Hewitt & Burbidge (1980). It is the brightest blazar in UV/X-ray energies in the southern hemisphere. It was discovered as a X-ray source by ..... Piner, B. G., Pant, N., Edwards, P. G. 2008, Astrophys. J., 678, 64. Rani, B., Wiita, P. J., Gupta, A. C. 2009, Astrophys. J., 696, 2170. Rani, B., Gupta, A. C., Joshi, U. C., Ganesh, S., ...

  11. SPECTRAL PROPERTIES OF BRIGHT FERMI-DETECTED BLAZARS IN THE GAMMA-RAY BAND

    International Nuclear Information System (INIS)

    Abdo, A. A.; Ackermann, M.; Ajello, M.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Bouvier, A.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Brez, A.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bonamente, E.; Brigida, M.

    2010-01-01

    The gamma-ray energy spectra of bright blazars of the LAT Bright AGN Sample (LBAS) are investigated using Fermi-LAT data. Spectral properties (hardness, curvature, and variability) established using a data set accumulated over 6 months of operation are presented and discussed for different blazar classes and subclasses: flat spectrum radio quasars (FSRQs), low-synchrotron peaked BLLacs (LSP-BLLacs), intermediate-synchrotron peaked BLLacs (ISP-BLLacs), and high-synchrotron peaked BLLacs (HSP-BLLacs). The distribution of photon index (Γ, obtained from a power-law fit above 100 MeV) is found to correlate strongly with blazar subclass. The change in spectral index from that averaged over the 6 months observing period is < 0.2-0.3 when the flux varies by about an order of magnitude, with a tendency toward harder spectra when the flux is brighter for FSRQs and LSP-BLLacs. A strong departure from a single power-law spectrum appears to be a common feature for FSRQs. This feature is also present for some high-luminosity LSP-BLLacs, and a small number of ISP-BLLacs. It is absent in all LBAS HSP-BLLacs. For 3C 454.3 and AO 0235+164, the two brightest FSRQ source and LSP-BLLac source, respectively, a broken power law (BPL) gives the most acceptable of power law, BPL, and curved forms. The consequences of these findings are discussed.

  12. Extremes of the jet-accretion power relation of blazars, as explored by NuSTAR

    DEFF Research Database (Denmark)

    Sbarrato, T.; Ghisellini, G.; Tagliaferri, G.

    2016-01-01

    Hard X-ray observations are crucial to study the non-thermal jet emission from high-redshift, powerful blazars. We observed two bright z > 2 flat-spectrum radio quasars (FSRQs) in hard X-rays to explore the details of their relativistic jets and their possible variability. S5 0014+81 (at z = 3.......366) and B0222+185 (at z = 2.690) have been observed twice by the Nuclear Spectroscopic Telescope Array (NuSTAR) simultaneously with Swift/X-ray Telescope, showing different variability behaviours. We found that NuSTAR is instrumental to explore the variability of powerful high-redshift blazars, even when...... no γ -ray emission is detected. The two sources have proven to have respectively the most luminous accretion disc and the most powerful jet among known blazars. Thanks to these properties, they are located at the extreme end of the jet-accretion disc relation previously found for γ -ray detected...

  13. Revisiting the incidence of Mg II absorbers along the blazar sightlines

    Science.gov (United States)

    Mishra, Sapna; Chand, Hum; Gopal-Krishna; Joshi, Ravi

    2018-04-01

    It is believed that the cool gas clouds traced by Mg II absorption, within a velocity offset of 5000 km/s from the background quasar, are associated with the quasar itself, whereas the absorbers seen at larger velocity offsets towards us are intervening systems and hence their existence is completely independent of the background quasar. Recent evidence by Bergeron et al. 2011 (hereafter BBM), however, seriously questions this canonical view, by showing that the number density of intervening Mg II absorbers along the sightlines towards 45 blazars is, on average, 2 times the expectation based on the Mg II absorption systems seen on the sightlines to normal QSOs. Given the serious implications of this finding, it becomes important to revisit this issue by enlarging the source sample and subjecting it to an independent analysis. Here, we first report our results based on a re-analysis of the spectroscopic data for the BBM sample; this has reproduced their factor 2 excess in dN/dz along blazar sightlines, vis-a-vis the normal QSOs. Next, we assemble a 6 times larger sample of blazar sightlines, albeit with lower SNR. Using this enlarged sample together with the BBM sample, our analysis shows that the dN/dz of Mg II absorbers statistically matches that known for normal QSO sightlines.

  14. OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. IV. RESULTS OF THE 2014 FOLLOW-UP CAMPAIGN

    International Nuclear Information System (INIS)

    Ricci, F.; Massaro, F.; Landoni, M.; D’Abrusco, R.; Milisavljevic, D.; Paggi, A.; Smith, Howard A.; Stern, D.; Masetti, N.; Tosti, G.

    2015-01-01

    The extragalactic γ-ray sky is dominated by the emission arising from blazars, one of the most peculiar classes of radio-loud active galaxies. Since the launch of Fermi several methods were developed to search for blazars as potential counterparts of unidentified γ-ray sources (UGSs). To confirm the nature of the selected candidates, optical spectroscopic observations are necessary. In 2013 we started a spectroscopic campaign to investigate γ-ray blazar candidates selected according to different procedures. The main goals of our campaign are: (1) to confirm the nature of these candidates, and (2) whenever possible, determine their redshifts. Optical spectroscopic observations will also permit us to verify the robustness of the proposed associations and check for the presence of possible source class contaminants to our counterpart selection. This paper reports the results of observations carried out in 2014 in the northern hemisphere with Kitt Peak National Observatory and in the southern hemisphere with the Southern Astrophysical Research telescopes. We also report three sources observed with the Magellan and Palomar telescopes. Our selection of blazar-like sources that could be potential counterparts of UGSs is based on their peculiar infrared colors and on their combination with radio observations both at high and low frequencies (i.e., above and below ∼1 GHz) in publicly available large radio surveys. We present the optical spectra of 27 objects. We confirm the blazar-like nature of nine sources that appear to be potential low-energy counterparts of UGSs. Then we present new spectroscopic observations of 10 active galaxies of uncertain type associated with Fermi sources, classifying all of them as blazars. In addition, we present the spectra for five known γ-ray blazars with uncertain redshift estimates and three BL Lac candidates that were observed during our campaign. We also report the case for WISE J173052.85−035247.2, candidate counterpart of the

  15. Probing the Diffuse Optical-IR Background with TeV Blazars Detected with the MAGIC Telescopes

    Directory of Open Access Journals (Sweden)

    Elisa Prandini

    2017-11-01

    Full Text Available Blazars are radio loud quasars whose jet points toward the observer. The observed emission is mostly non-thermal, dominated by the jet emission, and in some cases extends up to the very high energy gamma rays (VHE; E > 100 GeV. To date, more than 60 blazars have been detected at VHE mainly with ground-based imaging atmospheric Cherenkov telescopes (IACTs such as MAGIC, H.E.S.S., and VERITAS. Energetic photons from a blazar may interact with the diffuse optical and IR background (the extragalactic background light, EBL leaving an imprint on the blazar energy spectrum. This effect can be used to constrain the EBL, with basic assumptions on the intrinsic energy spectrum. Current generation of IACTs is providing valuable measurements of the EBL density and energy spectrum from optical to infrared frequencies. In this contribution, we present the latest results obtained with the data taken with the MAGIC telescopes: using 32 spectra from 12 blazars, the scale factor of the optical density predicted by the EBL model from Domínguez et al. (2011 is constrained to be 0.95 (+0.11, −0.12stat (+0.16, −0.07sys, where a value of 1 means the perfect match with the model.

  16. Probing the Diffuse Optical-IR Background with TeV Blazars Detected with the MAGIC Telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Prandini, Elisa [Dipartimento di Fisica e Astronomia “G. Galilei”, University of Padova, Padua (Italy); Domínguez, Alberto [Departamento de Física Atómica, Universidad Complutense, Madrid (Spain); Fallah Ramazani, Vandad [Tuorla observatory, University of Turku, Turku (Finland); Hassan, Tarek [IFAE, The Barcelona Institute of Science and Technology, Bellaterra (Spain); Mazin, Daniel [Max Planck Institute for Physics, Munich (Germany); Institute for Cosmic Ray Research, University of Tokyo, Tokyo (Japan); Moralejo, Abelardo [IFAE, The Barcelona Institute of Science and Technology, Bellaterra (Spain); Nievas Rosillo, Mireia [Departamento de Física Atómica, Universidad Complutense, Madrid (Spain); Vanzo, Gaia; Vazquez Acosta, Monica, E-mail: prandini@pd.infn.it [Instituto de Astrofísica de Canarias, Tenerife (Spain); Departamento de Astrofisica, Universidad de La Laguna, Tenerife (Spain)

    2017-11-22

    Blazars are radio loud quasars whose jet points toward the observer. The observed emission is mostly non-thermal, dominated by the jet emission, and in some cases extends up to the very high energy gamma rays (VHE; E > 100 GeV). To date, more than 60 blazars have been detected at VHE mainly with ground-based imaging atmospheric Cherenkov telescopes (IACTs) such as MAGIC, H.E.S.S., and VERITAS. Energetic photons from a blazar may interact with the diffuse optical and IR background (the extragalactic background light, EBL) leaving an imprint on the blazar energy spectrum. This effect can be used to constrain the EBL, with basic assumptions on the intrinsic energy spectrum. Current generation of IACTs is providing valuable measurements of the EBL density and energy spectrum from optical to infrared frequencies. In this contribution, we present the latest results obtained with the data taken with the MAGIC telescopes: using 32 spectra from 12 blazars, the scale factor of the optical density predicted by the EBL model from Domínguez et al. (2011) is constrained to be 0.95 (+0.11, −0.12){sub stat} (+0.16, −0.07){sub sys}, where a value of 1 means the perfect match with the model.

  17. Perturbation fields in W VII-AS and Helias configurations

    International Nuclear Information System (INIS)

    Harmeyer, E.; Kisslinger, J.; Montvai, A.; Rau, F.; Wobig, H.

    1988-01-01

    Effects of pertubed topologies of the W VII-AS vacuum fields on the configuration with rational and irrational rotational transform are illustrated. Even small perturbation fields are unacceptable at rational values of the rotational transform. For example at a rotational transform = 1/2 in W VII-AS, when exceeding an effective homogeneous Bx/B = 3 x 10 -4 , the size of the rotational transform = 1/2 = 5/10 islands is doubled. At irrational values a Bx/B = 1/2% shows tolerable effects, for both W VII-AS and HS4-12. At rational values of the rotational transform = 1 near the edge, Bx/B values = 1/4 to 1/8% show a rather large increase of the aspect ratio, so an edge value of rotational transform = 1 should be avoided

  18. PERANCANGAN SISTEM INFORMASI DI PTAIS KOPERTAIS WILAYAH VII SUMATERA SELATAN

    Directory of Open Access Journals (Sweden)

    Fenny Purwani

    2015-12-01

    Full Text Available Relations and information technology today closely related. One technology that is widely used and very popular on the Internet is a website. The website is agood means to facilitate and share information as much to college. However, the college today togetthe informationisnot maximized. This study aimstobuildawebsite on Kopertais SUMBAGSEL region VII. This website was developed using Macromedia Dreamweaver CS3 software, PHP, and MySQL, and method development using RAD (Rapid Application Development, and the purpose of this website serves to facilitate the college to receiver elevant information about online Kopertais VII region and terupdates.

  19. Analysis of the cumulative neutrino flux from Fermi LAT blazar populations using 3 years of IceCube data

    Directory of Open Access Journals (Sweden)

    Glüsenkamp Thorsten

    2016-01-01

    Full Text Available The recent discovery of a diffuse neutrino flux up to PeV energies raises the question of which populations of astrophysical sources contribute to this diffuse signal. One extragalactic candidate source population to produce high-energy neutrinos are Blazars. We present results from a likelihood analysis searching for cumulative neutrino emission from Blazar populations selected with the 2nd Fermi LAT AGN catalogue (2LAC using an IceCube data set that has been optimized for the detection of individual sources. In contrast to previous searches with IceCube, the investigated populations contain up to hundreds of sources, the biggest one being the entire Blazar sample measured by the Fermi-LAT. No significant neutrino signal was found from any of these populations. Some implications of this non-observation for the origin of the observed PeV diffuse signal will be discussed.

  20. 29 CFR 1604.8 - Relationship of title VII to the Equal Pay Act.

    Science.gov (United States)

    2010-07-01

    ... GUIDELINES ON DISCRIMINATION BECAUSE OF SEX § 1604.8 Relationship of title VII to the Equal Pay Act. (a) The employee coverage of the prohibitions against discrimination based on sex contained in title VII is...

  1. Theoretical Study of the Effects of Magnetic Field Geometry on the High-Energy Emission of Blazars

    Directory of Open Access Journals (Sweden)

    Manasvita Joshi

    2016-10-01

    Full Text Available The knowledge of the structure of the magnetic field inside a blazar jet, as deduced from polarization observations at radio to optical wavelengths, is closely related to the formation and propagation of relativistic jets that result from accretion onto supermassive black holes. However, a largely unexplored aspect of the theoretical understanding of radiation transfer physics in blazar jets has been the magnetic field geometry as revealed by the polarized emission and the connection between the variability in polarization and flux across the spectrum. Here, we explore the effects of various magnetic geometries that can exist inside a blazar jet: parallel, oblique, toroidal, and tangled. We investigate the effects of changing the orientation of the magnetic field, according to the above-mentioned geometries, on the resulting high-energy spectral energy distributions (SEDs and spectral variability patterns (SVPs of a typical blazar. We use the MUlti-ZOne Radiation Feedback (MUZORF model of Joshi et al. (2014 to carry out this study and to relate the geometry of the field to the observed SEDs at X-ray and γ-ray energies. One of the goals of the study is to understand the relationship between synchrotron and inverse Compton peaks in blazar SEDs and the reason for the appearance of γ-ray “orphan flares” observed in some blazars. This can be associated with the directionality of the magnetic field, which creates a difference in the radiation field as seen by an observer versus that seen by the electrons in the emission region.

  2. Research and characterisation of blazar candidates among the Fermi/LAT 3FGL catalogue using multivariate classifications

    Science.gov (United States)

    Lefaucheur, Julien; Pita, Santiago

    2017-06-01

    Context. In the recently published 3FGL catalogue, the Fermi/LAT collaboration reports the detection of γ-ray emission from 3034 sources obtained after four years of observations. The nature of 1010 of those sources is unknown, whereas 2023 have well-identified counterparts in other wavelengths. Most of the associated sources are labelled as blazars (1717/2023), but the BL Lac or FSRQ nature of 573 of these blazars is still undetermined. Aims: The aim of this study was two-fold. First, to significantly increase the number of blazar candidates from a search among the large number of Fermi/LAT 3FGL unassociated sources (case A). Second, to determine the BL Lac or FSRQ nature of the blazar candidates, including those determined as such in this work and the blazar candidates of uncertain type (BCU) that are already present in the 3FGL catalogue (case B). Methods: For this purpose, multivariate classifiers - boosted decision trees and multilayer perceptron neural networks - were trained using samples of labelled sources with no caution flag from the 3FGL catalogue and carefully chosen discriminant parameters. The decisions of the classifiers were combined in order to obtain a high level of source identification along with well controlled numbers of expected false associations. Specifically for case A, dedicated classifications were generated for high (| b | >10◦) and low (| b | ≤10◦) galactic latitude sources; in addition, the application of classifiers to samples of sources with caution flag was considered separately, and specific performance metrics were estimated. Results: We obtained a sample of 595 blazar candidates (high and low galactic latitude) among the unassociated sources of the 3FGL catalogue. We also obtained a sample of 509 BL Lacs and 295 FSRQs from the blazar candidates cited above and the BCUs of the 3FGL catalogue. The number of expected false associations is given for different samples of candidates. It is, in particular, notably low ( 9

  3. Viis aastakümmet raamatukogunduse radadel / Anne Veinberg

    Index Scriptorium Estoniae

    Veinberg, Anne

    2008-01-01

    Arvustus: Kikas, Konrad. Verba volant, scripta manent : viis aastakümmet raamatukogunduse ja infoteaduse radadel = Verba volant, scripta manent : five decades on the field of librarianship and information science. - Tallinn : Tallinna Tehnikaülikooli Kirjastus, 2008. - 366 lk. : ill. portr. - (Tallinna Tehnikaülikooli Raamatukogu töid. A ; 5)

  4. Viis armastuslugu suurel ekraanil / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2008-01-01

    Viis näidet filmiajaloost, kus režissööri ja staari vahel on tunded : Roger Vadim ja Tema Naised, Werner Herzog ja Klaus Kinski, Federico Fellini ja Anita Ekberg, Quentin Tarantino ja Uma Thurman, Rainer Werner Fassbinder ja Mr/Mrs X

  5. Mechanisms of coexistence of factor VII hyperactivity with ...

    African Journals Online (AJOL)

    Dyslipidaemia, DM and obesity were found to induce FVII hyperactivity. Hyperglycaemia, insulin resistance, high levels of FFAs and leptin constitute the underlying mechanisms for coexistence of FVII hyperactivity and metabolic disorders. Factor VII hyperactivity does not cause development of MI de novo. In conclusion ...

  6. In silico dissection of Type VII Secretion System components across

    Indian Academy of Sciences (India)

    Type VII Secretion System (T7SS) is one of the factors involved in virulence of Mycobacteriun tuberculosis H37Rv. Numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. An extensive genome-wide analysis through compilation of isolated information ...

  7. In silico dissection of Type VII Secretion System components across ...

    Indian Academy of Sciences (India)

    2016-02-12

    Feb 12, 2016 ... tomycetes, Cyanobacteria and Spirochaetes. This indicates a higher likelihood of the presence of Type VII-like Secretion. Systems in bacterial species belonging to these seven phyla. Apart from the secretory proteins of WXG100 family, homologs of ATPase component (T7SSC5) and the protease.

  8. In silico dissection of Type VII Secretion System components across ...

    Indian Academy of Sciences (India)

    Type VII Secretion System (T7SS) is one of the factors involved in virulence of Mycobacteriun tuberculosis H37Rv. Numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. An extensive genome-wide analysis through compilation of isolated information ...

  9. In silico dissection of Type VII Secretion System components across ...

    Indian Academy of Sciences (India)

    2016-02-12

    Feb 12, 2016 ... utilizing these components as 'seeds'. Information on the iden- tified components of T7SS has been organized into a database. T7CD (Type VII Secretion System Component Database). The present study suggests a global trend of distinct structural com- ponents (of T7SS) in Actinobacteria and Firmicutes.

  10. 76 FR 31892 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2011-06-02

    ... Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION: Notice... Civil Rights Act of 1964 (Title VII) and the Americans with Disabilities Act (ADA) to entities covered... the same record retention requirements under GINA that are imposed under Title VII and the ADA, i.e...

  11. 76 FR 79065 - Recordkeeping and Reporting Requirements Under Title VII, the ADA and GINA

    Science.gov (United States)

    2011-12-21

    ... Reporting Requirements Under Title VII, the ADA and GINA CFR Correction In Title 29 of the Code of Federal... title VII or section 107 of the ADA'' and add in their place the words ``section 709(c) of title VII, section 107 of the ADA, or section 207(a) of GINA'' wherever they appear in the following sections...

  12. 77 FR 5396 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2012-02-03

    ... Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION: Final... (Title VII) and the Americans with Disabilities Act (ADA) to entities covered by title II of the Genetic... requirements under GINA that apply under Title VII and the ADA, i.e., any records made or kept must be retained...

  13. 78 FR 36011 - Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing

    Science.gov (United States)

    2013-06-14

    ... SMALL BUSINESS ADMINISTRATION Region VII Regulatory Fairness Board; Federal Regulatory Enforcement... Regional (Region VII) Small Business Regulatory Fairness Board. SUMMARY: The (SBA) Office of the National... the Region VII Regulatory Fairness Board must contact Jeanna Trenkamp by June 17, 2013 in writing, by...

  14. Detection techniques for the H.E.S.S. II telescope, data modeling of gravitational lensing and emission of blazars in HE-VHE astronomy

    International Nuclear Information System (INIS)

    Barnacka, Anna

    2013-01-01

    This thesis presents the study of four aspects of high energy astronomy. The first part of my thesis is dedicated to an aspect of instrument development for imaging atmospheric Cherenkov telescopes, namely the Level 2 trigger system of the High Energy Stereoscopic System (H.E.S.S.). My work on the project focused on the algorithm development and the Monte Carlo simulations of the trigger system and overall instrument. The hardware implementation of the system is described and its expected performances are then evaluated. The H.E.S.S. array has been used to observe the blazar PKS 1510-089. The second part of my thesis deals with the data analysis and modeling of broad-band emission of this particular blazar. In part II of my thesis, I am presenting the analysis of the H.E.S.S. data: the light curve and spectrum of PKS 1510-089, together with the FERMI data and a collection of multi-wavelength data obtained with various instruments. I am presenting the model of PKS 1510-089 observations carried out during a flare recorded by H.E.S.S.. The model is based on a single zone internal shock scenario. The third part of my thesis deals with blazars observed by the FERMI-LAT, but from the point of view of other phenomena: a strong gravitational lensing. This part of my thesis shows the first evidence for gravitational lensing phenomena in high energy gamma-rays. This evidence comes from the observation of a gravitational lens system induced echo in the light curve of the distant blazar PKS 1830-211. Traditional methods for the estimation of time delays in gravitational lensing systems rely on the cross-correlation of the light curves from individual images. In my thesis, I used 300 MeV-30 GeV photons detected by the Fermi-LAT instrument. The FERMI-LAT instrument cannot separate the images of known lenses. The observed light curve is thus the superposition of individual image light curves. The FERMI-LAT instrument has the advantage of providing long, evenly spaced, time series

  15. X-Ray Intraday Variability of Five TeV Blazars with NuSTAR

    Energy Technology Data Exchange (ETDEWEB)

    Pandey, Ashwani; Gupta, Alok C. [Aryabhatta Research Institute of Observational Sciences (ARIES), Manora Peak, Nainital 263002 (India); Wiita, Paul J., E-mail: ashwanitapan@gmail.com, E-mail: acgupta30@gmail.com, E-mail: wiitap@tcnj.edu [Department of Physics, The College of New Jersey, 2000 Pennington Road, Ewing, NJ 08628-0718 (United States)

    2017-06-01

    We have examined 40 Nuclear Spectroscopic Telescope Array ( NuSTAR ) light curves (LCs) of five TeV emitting high synchrotron peaked blazars: 1ES 0229+200, Mrk 421, Mrk 501, 1ES 1959+650, and PKS 2155−304. Four of the blazars showed intraday variability in the NuSTAR energy range of 3–79 keV. Using an autocorrelation function analysis we searched for intraday variability timescales in these LCs and found indications of several between 2.5 and 32.8 ks in eight LCs of Mrk 421, a timescale around 8.0 ks for one LC of Mrk 501, and timescales of 29.6 and 57.4 ks in two LCs of PKS 2155-304. The other two blazars’ LCs do not show any evidence for intraday variability timescales shorter than the lengths of those observations; however, the data were both sparser and noisier for them. We found positive correlations with zero lag between soft (3–10 keV) and hard (10–79 keV) bands for most of the LCs, indicating that their emissions originate from the same electron population. We examined spectral variability using a hardness ratio analysis and noticed a general “harder-when-brighter” behavior. The 22 LCs of Mrk 421 observed between 2012 July and 2013 April show that this source was in a quiescent state for an extended period of time and then underwent an unprecedented double-peaked outburst while monitored on a daily basis during 2013 April 10–16. We briefly discuss models capable of explaining these blazar emissions.

  16. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Skouby, Sven O; Kluft, Cornelis

    2011-01-01

    Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...

  17. Secondary photons and neutrinos from cosmic rays produced by distant blazars.

    Science.gov (United States)

    Essey, Warren; Kalashev, Oleg E; Kusenko, Alexander; Beacom, John F

    2010-04-09

    Secondary photons and neutrinos produced in the interactions of cosmic ray protons emitted by distant active galactic nuclei (AGN) with the photon background along the line of sight can reveal a wealth of new information about the intergalactic magnetic fields, extragalactic background light, and the acceleration mechanisms of cosmic rays. The secondary photons may have already been observed by gamma-ray telescopes. We show that the secondary neutrinos improve the prospects of discovering distant blazars by IceCube, and we discuss the ramifications for the cosmic backgrounds, magnetic fields, and AGN models.

  18. Broad Band Observations of Gravitationally Lensed Blazar during a Gamma-Ray Outburst

    Directory of Open Access Journals (Sweden)

    Julian Sitarek

    2016-09-01

    Full Text Available QSO B0218+357 is a gravitationally lensed blazar located at a cosmological redshift of 0.944. In July 2014 a GeV flare was observed by Fermi-LAT, triggering follow-up observations with the MAGIC telescopes at energies above 100 GeV. The MAGIC observations at the expected time of arrival of the trailing component resulted in the first detection of QSO B0218+357 in Very-High-Energy (VHE, >100 GeV gamma rays. We report here the observed multiwavelength emission during the 2014 flare.

  19. Gamma-ray astronomy from the ground and the space: first analyses of the HESS-II hybrid array and search for blazar candidates among the unidentified Fermi-LAT sources

    International Nuclear Information System (INIS)

    Lefaucheur, Julien

    2015-01-01

    This manuscript is about high energy gamma-ray astronomy (between 30 GeV and 300 GeV) with the Fermi-LAT satellite and very high energy gamma-ray astronomy (above ∼100 GeV) via the H.E.S.S. experiment. The second phase of the H.E.S.S. experiment began in July 2012 with the inauguration of a fifth 28 m-diameter telescope added to the initial array composed of four 12 m-diameter imaging atmospheric Cherenkov telescopes. In the first part of this thesis, we present the development of an analysis in hybrid mode based on a multivariate method dedicated to detect and study sources with different spectral shapes and the first analysis results on real data. The second part is dedicated to the research of blazar candidates among the Fermi-LAT unidentified sources of the 2FGL catalog. A first development is based on a multivariate approach using discriminant parameters built with the 2FGL catalog parameters. A second development is done with the use of the WISE satellite catalog and a non-parametric technic in order to find the blazar-like infrared counterparts of the unidentified sources of the 2FGL catalog. (author)

  20. SALT-HRS observation of the blazar TXS 0506+056 associated with IceCube-170922A

    Science.gov (United States)

    van Soelen, B.; Buckley, David A. H.; Boettcher, Markus

    2017-10-01

    The blazar TXS 0506+056, which has been proposed as the counterpart to the neutrino event IceCube-170922A, has recently been reported to show increased optical and gamma-ray emission (ATel #10817, #10801, #10799, #10794, #10792, #10791, #10787, #10773).

  1. Intra-night Optical Variability Monitoring of Fermi Blazars: First Results from 1.3 m J. C. Bhattacharya Telescope

    International Nuclear Information System (INIS)

    Paliya, Vaidehi S.; Ajello, M.; Kaur, A.; Stalin, C. S.

    2017-01-01

    We report the first results obtained from our campaign to characterize the intra-night-optical variability (INOV) properties of Fermi detected blazars, using the observations from the recently commissioned 1.3 m J. C. Bhattacharya telescope (JCBT). During the first run, we were able to observe 17 blazars in the Bessel R filter for ∼137 hr. Using C- and scaled F -statistics, we quantify the extent of INOV and derive the duty cycle (DC), which is the fraction of time during which a source exhibits a substantial flux variability. We find a high DC of 40% for BL Lac objects and the flat spectrum radio quasars are relatively less variable (DC ∼ 15%). However, when estimated for blazars sub-classes, a high DC of ∼59% is found in low synchrotron peaked (LSP) blazars, whereas, intermediate and high synchrotron peaked objects have a low DC of ∼11% and 13%, respectively. We find evidence of the association of the high amplitude INOV with the γ -ray flaring state. We also notice a high polarization during the elevated INOV states (for the sources that have polarimetric data available), thus supporting the jet based origin of the observed variability. We plan to enlarge the sample and utilize the time availability from the small telescopes, such as 1.3 m JCBT, to strengthen/verify the results obtained in this work and those existing in the literature.

  2. Results of the first simultaneous X-ray, optical, and radio campaign on the blazar PKS 1622-297

    NARCIS (Netherlands)

    Meyer, Angela Osterman; Miller, H. Richard; Marshall, Kevin; Ryle, Wesley T.; Aller, Hugh; Aller, Margo; McFarland, John P.; Pollock, Joseph T.; Reichart, Daniel E.; Crain, J. Adam; Ivarsen, Kevin M.; LaCluyze, Aaron P.; Nysewander, Melissa C.

    Coordinated X-ray, optical, and radio observations of the blazar PKS 1622-297 were obtained during a three-week campaign in 2006 using the Rossi X-Ray Timing Explorer (RXTE), the University of Michigan Radio Astronomy Observatory, and optical telescopes at Cerro Tololo Inter-American Observatory.

  3. Intra-night Optical Variability Monitoring of Fermi Blazars: First Results from 1.3 m J. C. Bhattacharya Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Paliya, Vaidehi S.; Ajello, M.; Kaur, A. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Stalin, C. S., E-mail: vpaliya@g.clemson.edu [Indian Institute of Astrophysics, Block II, Koramangala, Bangalore-560034 (India)

    2017-07-20

    We report the first results obtained from our campaign to characterize the intra-night-optical variability (INOV) properties of Fermi detected blazars, using the observations from the recently commissioned 1.3 m J. C. Bhattacharya telescope (JCBT). During the first run, we were able to observe 17 blazars in the Bessel R filter for ∼137 hr. Using C- and scaled F -statistics, we quantify the extent of INOV and derive the duty cycle (DC), which is the fraction of time during which a source exhibits a substantial flux variability. We find a high DC of 40% for BL Lac objects and the flat spectrum radio quasars are relatively less variable (DC ∼ 15%). However, when estimated for blazars sub-classes, a high DC of ∼59% is found in low synchrotron peaked (LSP) blazars, whereas, intermediate and high synchrotron peaked objects have a low DC of ∼11% and 13%, respectively. We find evidence of the association of the high amplitude INOV with the γ -ray flaring state. We also notice a high polarization during the elevated INOV states (for the sources that have polarimetric data available), thus supporting the jet based origin of the observed variability. We plan to enlarge the sample and utilize the time availability from the small telescopes, such as 1.3 m JCBT, to strengthen/verify the results obtained in this work and those existing in the literature.

  4. Technetium (VII) Co-precipitation with Framework Aluminosilicates

    Energy Technology Data Exchange (ETDEWEB)

    Harsh, James B. [Washington State Univ., Pullman, WA (United States); Dickson, Johnbull Otah [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pierce, Eric M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bargar, John [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-07-13

    Technetium-99 (99Tc), a long-lived radionuclide, is one of the most widespread contaminants within the Hanford subsurface. At some depths, it is only extractable with strong acids, suggesting incorporation into a solid phase. We hypothesized that Tc may have coprecipitated with feldspathoid aluminosilicates under waste tanks that had leaked caustic solutions into the vadose zone. Our objectives were to determine if Tc could be incorporated into the feldspathoids cancrinite and sodalite and under what conditions coprecipitation could occur. Our hypothesis was that sodalite was more likely to incorporate and retain Tc. Our approach was to use known methods of feldspathoid formation in solutions resembling those in Hanford waste tanks contacting sediments in terms of major ion (Na, NO3, OH, Al(OH)4, and Si(OH)4 concentrations. In some cases, Al and Si were supplied from zeolite. We used perrhenate (ReO4) as a surrogate for pertechnetate (TcO4) to avoid the radioactivity. The major findings of this study were 1) ReO4 could be incorporated into either sodalite or cancrinite but the concentration in the solid was < 1% of the competing ion Cl, NO3, or NO2. 2) The small amount of ReO4 incorporated was not exchangeable with NO3 or NO2. 3) In sodalite, NO3 was highly preferred over ReO4 but significant Re-sodalite was formed when the mole fraction in solution (Re/Re+N) exceeded 0.8. 4) A nonlinear relation between the unit cell parameter and amount of Re incorporated suggested that a separate Re-sodalite phase was formed rather than a solid solution. 5) We determined that sodalite preference for sodalite in the presence of different anions increased with the ionic size of the competing anion: Cl < CO3 < NO3 < SO4 < MnO4 < WO4 and significant incorporation did not occur unless the difference in anion radii was less than 12%. 6) Re(VII) was not significantly reduced to Re(IV) under the conditions of this experiment and Re appeared to be a good surrogate for Tc under oxidizing

  5. The role of plasma instabilities in the propagation of gamma-rays from distant Blazars

    Energy Technology Data Exchange (ETDEWEB)

    Saveliev, A.; Evoli, C.; Sigl, G. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2013-11-15

    The observation in the GeV band of distant blazars has been recently used to put constraints on the Extragalactic Background Light (EBL) and Extragalactic Magnetic Fields (EGMF). To support such claims one has to assume that the leptonic component of the electromagnetic cascade initiated by blazar gamma-rays is deflected away by strong enough EGMF, suppressing the signal in the Fermi window. Apart from magnetic fields, the development of such a cascade might be affected by plasma instabilities due to interactions with the ionized component of the Intergalactic Medium (IGM). In this paper we model the electromagnetic cascade through a Monte Carlo simulation in which both effects are taken into account separately, and we derive constraints on these scenarios from the combined Fermi-HESS data set. In the specific case of 1ES 0229+200 observations, we show that both explanations of the GeV flux suppression are compatible with the available data, specifically by assuming a magnetic field of B >or similar 10{sup -16} G or an IGM temperature of T

  6. Search for neutrino emission from gamma-ray flaring blazars with the ANTARES telescope

    Science.gov (United States)

    Adrián-Martínez, S.; Al Samarai, I.; Albert, A.; André, M.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Astraatmadja, T.; Aubert, J.-J.; Baret, B.; Basa, S.; Bertin, V.; Biagi, S.; Bigongiari, C.; Bogazzi, C.; Bou-Cabo, M.; Bouhou, B.; Bouwhuis, M. C.; Brunner, J.; Busto, J.; Camarena, F.; Capone, A.; Cârloganu, C.; Carminati, G.; Carr, J.; Cecchini, S.; Charif, Z.; Charvis, Ph.; Chiarusi, T.; Circella, M.; Core, L.; Costantini, H.; Coyle, P.; Creusot, A.; Curtil, C.; De Bonis, G.; Decowski, M. P.; Dekeyser, I.; Deschamps, A.; Distefano, C.; Donzaud, C.; Dornic, D.; Dorosti, Q.; Drouhin, D.; Eberl, T.; Emanuele, U.; Enzenhöfer, A.; Ernenwein, J.-P.; Escoffier, S.; Fehn, K.; Fermani, P.; Ferri, M.; Ferry, S.; Flaminio, V.; Folger, F.; Fritsch, U.; Fuda, J.-L.; Galatà, S.; Gay, P.; Geyer, K.; Giacomelli, G.; Giordano, V.; Gómez-González, J. P.; Graf, K.; Guillard, G.; Halladjian, G.; Hallewell, G.; van Haren, H.; Hartman, J.; Heijboer, A. J.; Hello, Y.; Hernández-Rey, J. J.; Herold, B.; Hößl, J.; Hsu, C. C.; de Jong, M.; Kadler, M.; Kalekin, O.; Kappes, A.; Katz, U.; Kavatsyuk, O.; Kooijman, P.; Kopper, C.; Kouchner, A.; Kreykenbohm, I.; Kulikovskiy, V.; Lahmann, R.; Lambard, G.; Larosa, G.; Lattuada, D.; Lefèvre, D.; Lim, G.; Lo Presti, D.; Loehner, H.; Loucatos, S.; Louis, F.; Mangano, S.; Marcelin, M.; Margiotta, A.; Martínez-Mora, J. A.; Meli, A.; Montaruli, T.; Morganti, N.; Moscoso, L.; Motz, H.; Neff, M.; Nezri, E.; Palioselitis, D.; Păvălaş, G. E.; Payet, K.; Payre, P.; Petrovic, J.; Piattelli, P.; Picot-Clemente, N.; Popa, V.; Pradier, T.; Presani, E.; Racca, C.; Reed, C.; Riccobene, G.; Richardt, C.; Richter, R.; Rivière, C.; Robert, A.; Roensch, K.; Rostovtsev, A.; Ruiz-Rivas, J.; Rujoiu, M.; Russo, G. V.; Salesa, F.; Samtleben, D. F. E.; Sapienza, P.; Schöck, F.; Schuller, J.-P.; Schüssler, F.; Seitz, T.; Shanidze, R.; Simeone, F.; Spies, A.; Spurio, M.; Steijger, J. J. M.; Stolarczyk, Th.; Sánchez-Losa, A.; Taiuti, M.; Tamburini, C.; Toscano, S.; Vallage, B.; Vallée, C.; Van Elewyck, V.; Vannoni, G.; Vecchi, M.; Vernin, P.; Visser, E.; Wagner, S.; Wijnker, G.; Wilms, J.; de Wolf, E.; Yepes, H.; Zaborov, D.; Zornoza, J. D.; Zúñiga, J.

    2012-08-01

    The ANTARES telescope is well-suited to detect neutrinos produced in astrophysical transient sources as it can observe a full hemisphere of the sky at all times with a high duty cycle. Radio-loud active galactic nuclei with jets pointing almost directly towards the observer, the so-called blazars, are particularly attractive potential neutrino point sources. The all-sky monitor LAT on board the Fermi satellite probes the variability of any given gamma-ray bright blazar in the sky on time scales of hours to months. Assuming hadronic models, a strong correlation between the gamma-ray and the neutrino fluxes is expected. Selecting a narrow time window on the assumed neutrino production period can significantly reduce the background. An unbinned method based on the minimization of a likelihood ratio was applied to a subsample of data collected in 2008 (61 days live time). By searching for neutrinos during the high state periods of the AGN light curve, the sensitivity to these sources was improved by about a factor of two with respect to a standard time-integrated point source search. First results on the search for neutrinos associated with ten bright and variable Fermi sources are presented.

  7. RECONCILING MODELS OF LUMINOUS BLAZARS WITH MAGNETIC FLUXES DETERMINED BY RADIO CORE-SHIFT MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Nalewajko, Krzysztof; Begelman, Mitchell C. [JILA, University of Colorado and National Institute of Standards and Technology, 440 UCB, Boulder, CO 80309 (United States); Sikora, Marek, E-mail: knalew@stanford.edu [Nicolaus Copernicus Astronomical Center, Bartycka 18, 00-716 Warsaw (Poland)

    2014-11-20

    Estimates of magnetic field strength in relativistic jets of active galactic nuclei, obtained by measuring the frequency-dependent radio core location, imply that the total magnetic fluxes in those jets are consistent with the predictions of the magnetically arrested disk (MAD) scenario of jet formation. On the other hand, the magnetic field strength determines the luminosity of the synchrotron radiation, which forms the low-energy bump of the observed blazar spectral energy distribution (SED). The SEDs of the most powerful blazars are strongly dominated by the high-energy bump, which is most likely due to the external radiation Compton mechanism. This high Compton dominance may be difficult to reconcile with the MAD scenario, unless (1) the geometry of external radiation sources (broad-line region, hot-dust torus) is quasi-spherical rather than flat, or (2) most gamma-ray radiation is produced in jet regions of low magnetization, e.g., in magnetic reconnection layers or in fast jet spines.

  8. Testing the Equivalence Principle and Lorentz Invariance with PeV Neutrinos from Blazar Flares.

    Science.gov (United States)

    Wang, Zi-Yi; Liu, Ruo-Yu; Wang, Xiang-Yu

    2016-04-15

    It was recently proposed that a giant flare of the blazar PKS B1424-418 at redshift z=1.522 is in association with a PeV-energy neutrino event detected by IceCube. Based on this association we here suggest that the flight time difference between the PeV neutrino and gamma-ray photons from blazar flares can be used to constrain the violations of equivalence principle and the Lorentz invariance for neutrinos. From the calculated Shapiro delay due to clusters or superclusters in the nearby universe, we find that violation of the equivalence principle for neutrinos and photons is constrained to an accuracy of at least 10^{-5}, which is 2 orders of magnitude tighter than the constraint placed by MeV neutrinos from supernova 1987A. Lorentz invariance violation (LIV) arises in various quantum-gravity theories, which predicts an energy-dependent velocity of propagation in vacuum for particles. We find that the association of the PeV neutrino with the gamma-ray outburst set limits on the energy scale of possible LIV to >0.01E_{pl} for linear LIV models and >6×10^{-8}E_{pl} for quadratic order LIV models, where E_{pl} is the Planck energy scale. These are the most stringent constraints on neutrino LIV for subluminal neutrinos.

  9. RAPID OPTICAL VARIABILITY IN BLAZAR S5 0716+71 DURING 2010 MARCH

    International Nuclear Information System (INIS)

    Chandra, S.; Baliyan, K. S.; Ganesh, S.; Joshi, U. C.

    2011-01-01

    We report rapid optical variability for the blazar S5 0716+71 during 2010 March 8-10 and 19-20 in the CCD observations made from Mt. Abu Infrared Observatory. The light curves are constructed for a duration longer than 3 hr each night, with very high temporal resolution (∼45 s in the R band). During 2010 March 8, the source smoothly decayed by about 0.15 mag in 2.88 hr, apart from a fast flicker lasting about 30 minutes. S5 0716+71 brightened during March 9 and 10, showing high activity, while it was relatively faint (>14 mag in the R band) albeit variable during March 19-20. During March 9 and 10, rapid flickers in the intensity modulated the long-term intra-night (∼3 hr) variations. The present observations suggest that the blazar S5 0716+71 showed night-to-night and intra-night variability at various timescales with a 100% duty cycle for variation along with microvariability at significant levels. On a night-to-night basis, the source exhibits mild bluer-when-brighter nature. The interaction of shocks with local inhomogeneities in the jet appears to cause intra-night variations, while microvariations could be due to small-scale perturbations intrinsic to the jet.

  10. AWAKENING OF THE HIGH-REDSHIFT BLAZAR CGRaBS J0809+5341

    Energy Technology Data Exchange (ETDEWEB)

    Paliya, Vaidehi S.; Stalin, C. S. [Indian Institute of Astrophysics, Block II, Koramangala, Bangalore 560034 (India); Parker, M. L.; Fabian, A. C. [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom); Ramya, S. [Shanghai Astronomical Observatory, 80 Nandan Road, Shanghai 200030 (China); Covino, S.; Tagliaferri, G. [INAF-Osservatorio Astronomico di Brera, Via Bianchi 46, I-23807 Merate (Italy); Sahayanathan, S. [Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Ravikumar, C. D., E-mail: vaidehi@iiap.res.in [Department of Physics, University of Calicut, Malappuram 673635 (India)

    2015-04-20

    CGRaBS J0809+5341, a high-redshift blazar at z = 2.144, underwent a giant optical outburst on 2014 April 19 when it brightened by ∼5 mag and reached an unfiltered apparent magnitude of 15.7 mag. This implies an absolute magnitude of −30.5 mag, making it one of the brightest quasars in the universe. This optical flaring triggered us to carry out observations during the decaying part of the flare covering a wide energy range using the Nuclear Spectroscopic Telescope Array, Swift, and ground-based optical facilities. For the first time, the source is detected in γ-rays by the Large Area Telescope on board the Fermi Gamma-Ray Space Telescope. A high optical polarization of ∼10% is also observed. Using the Sloan Digital Sky Survey spectrum, the accretion disk luminosity and black hole mass are estimated as 1.5 × 10{sup 45} erg s{sup −1} and 10{sup 8.4} M{sub ⊙}, respectively. Using a single zone leptonic emission model, we reproduce the spectral energy distribution of the source during the flaring activity. This analysis suggests that the emission region is probably located outside the broad-line region, and the jet becomes radiatively efficient. We also show that the overall properties of CGRaBS J0809+5341 seem to not be in agreement with the general properties observed in high-redshift blazars up to now.

  11. The “Far Site” Scenario for Gamma-ray Emission in Blazars

    Directory of Open Access Journals (Sweden)

    Agudo Iván

    2013-12-01

    Full Text Available Since the birth of γ-ray astronomy, locating the origin of γ-ray emission has been a fundamental problem for the knowledge of the emission processes involved. Densely time sampled monitoring programs with very long baseline interferometry and the Fermi Gamma-ray Space Telescope, together with several other facilities at most of the available spectral ranges (including polarization measurements if possible are starting to shed new light for the case of blazars. A successful observing technique consists on analyzing the timing of multi-waveband variations in the flux and linear polarization, as well as changes in ultra-high resolution VLBI images to associate the particularly bright events at different wavebands. Such association can be robustly demonstrated by probing the statistical significance of the correlation among spectral ranges through Monte Carlo simulations. The location of the high energy emission region is inferred through its relative location with regard to the associated low energy event observed in the VLBI images. In this paper, I present some of the latest results using this method that locate the GeV emission within the jets of blazars AO 0235+164 and OJ287 at > 12 pc from the central AGN engine, hence supporting the “far site” scenario.

  12. Blazar Variability from Turbulence in Jets Launched by Magnetically Arrested Accretion Flows

    Energy Technology Data Exchange (ETDEWEB)

    Riordan, Michael O’; Pe’er, Asaf [Physics Department, University College Cork, Cork (Ireland); McKinney, Jonathan C., E-mail: michael_oriordan@umail.ucc.ie [Department of Physics and Joint Space-Science Institute, University of Maryland, College Park, MD 20742 (United States)

    2017-07-10

    Blazars show variability on timescales ranging from minutes to years, the former being comparable to and in some cases even shorter than the light-crossing time of the central black hole. The observed γ -ray light curves can be described by a power-law power density spectrum (PDS), with a similar index for both BL Lacs and flat-spectrum radio quasars. We show that this variability can be produced by turbulence in relativistic jets launched by magnetically arrested accretion flows (MADs). We perform radiative transport calculations on the turbulent, highly magnetized jet launching region of a MAD with a rapidly rotating supermassive black hole. The resulting synchrotron and synchrotron self-Compton emission, originating from close to the black hole horizon, is highly variable. This variability is characterized by PDS, which is remarkably similar to the observed power-law spectrum at frequencies less than a few per day. Furthermore, turbulence in the jet launching region naturally produces fluctuations in the plasma on scales much smaller than the horizon radius. We speculate that similar turbulent processes, operating in the jet at large radii (and therefore a high bulk Lorentz factor), are responsible for blazar variability over many decades in frequency, including on minute timescales.

  13. Discovery of a GeV Blazar Shining Through the Galactic Plane

    Energy Technology Data Exchange (ETDEWEB)

    Vandenbroucke, J.; Buehler, R.; Ajello, M.; Bechtol, K.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Bellini, A.; /Padua U., Astron. Dept. /Baltimore, Space Telescope Sci.; Bolte, M.; /UC, Santa Cruz; Cheung, C.C.; /Naval Research Lab, Wash., D.C. /NAS, Washington, D.C.; Civano, F.; /Smithsonian Astrophys. Observ.; Donato, D.; /NASA, Goddard; Fuhrmann, L.; /Bonn, Max Planck Inst., Radioastron.; Funk, S.; Healey, S.E.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Hill, A.B.; /Joseph Fourier U.; Knigge, C.; /Southampton U.; Madejski, G.M.; Romani, R.W.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Santander-Garcia, M.; /IAC, La Laguna /Isaac Newton Group /Laguna U., Tenerife; Shaw, M.S.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Steeghs, D.; /Warwick U.; Torres, M.A.P.; /Smithsonian Astrophys. Observ.; Van Etten, A.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC /Texas U., Astron. Dept.

    2011-08-11

    The Fermi Large Area Telescope (LAT) discovered a new gamma-ray source near the Galactic plane, Fermi J0109+6134, when it flared brightly in 2010 February. The low Galactic latitude (b = -1.2{sup o}) indicated that the source could be located within the Galaxy, which motivated rapid multi-wavelength follow-up including radio, optical, and X-ray observations. We report the results of analyzing all 19 months of LAT data for the source, and of X-ray observations with both Swift and the Chandra X-ray Observatory. We determined the source redshift, z = 0.783, using a Keck LRIS observation. Finally, we compiled a broadband spectral energy distribution (SED) from both historical and new observations contemporaneous with the 2010 February flare. The redshift, SED, optical line width, X-ray obsorption, and multi-band variability indicate that this new Gev source is a blazar seen through the Galactic plane. Because several of the optical emission lines have equivalent width > 5 {angstrom}, this blazar belongs in the flat-spectrum radio quasar category.

  14. Nustar detection of the blazar B2 1023+25 at redshift 5.3

    DEFF Research Database (Denmark)

    Sbarrato, T.; Tagliaferri, G.; Ghisellini, G.

    2013-01-01

    B2 1023+25 is an extremely radio-loud quasar at z = 5.3 that was first identified as a likely high-redshift blazar candidate in the SDSS+FIRST quasar catalog. Here, we use the Nuclear Spectroscopic Telescope Array (NuSTAR) to investigate its non-thermal jet emission, whose high-energy component we...... detected in the hard X-ray energy band. The X-ray flux is ~5.5 × 10-14 erg cm-2 s-1 (5-10 keV) and the photon spectral index is ΓX ≃ 1.3-1.6. Modeling the full spectral energy distribution, we find that the jet is oriented close to the line of sight, with a viewing angle of ~3°, and has significant Doppler...... boosting, with a large bulk Lorentz factor ~13, which confirms the identification of B2 1023+25 as a blazar. B2 1023+25 is the first object at redshift larger than 5 detected by NuSTAR, demonstrating the ability of NuSTAR to investigate the early X-ray universe and to study extremely active supermassive...

  15. PERANCANGAN SISTEM INFORMASI DI PTAIS KOPERTAIS WILAYAH VII SUMATERA SELATAN

    OpenAIRE

    Fenny Purwani

    2015-01-01

    Relations and information technology today closely related. One technology that is widely used and very popular on the Internet is a website. The website is agood means to facilitate and share information as much to college. However, the college today togetthe informationisnot maximized. This study aimstobuildawebsite on Kopertais SUMBAGSEL region VII. This website was developed using Macromedia Dreamweaver CS3 software, PHP, and MySQL, and method development using RAD (Rapid Application Deve...

  16. OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. VI. FURTHER OBSERVATIONS FROM TNG, WHT, OAN, SOAR, AND MAGELLAN TELESCOPES

    Energy Technology Data Exchange (ETDEWEB)

    Álvarez Crespo, N.; Massaro, F. [Dipartimento di Fisica, Università degli Studi di Torino, via Pietro Giuria 1, I-10125 Torino (Italy); Milisavljevic, D.; Paggi, A.; Smith, Howard A. [Harvard—Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Landoni, M. [INAF-Osservatorio Astronomico di Brera, Via Emilio Bianchi 46, I-23807 Merate (Italy); Chavushyan, V.; Patiño-Álvarez, V. [Instituto Nacional de Astrofísica, Óptica y Electrónica, Apartado Postal 51-216, 72000 Puebla, México (Mexico); Masetti, N. [INAF—Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129, Bologna (Italy); Jiménez-Bailón, E. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apdo. Postal 877, Ensenada, 22800 Baja California, México (Mexico); Strader, J.; Chomiuk, L. [Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States); Katagiri, H.; Kagaya, M. [College of Science, Ibaraki University, 2-1-1, Bunkyo, Mito 310-8512 (Japan); Cheung, C. C. [Space Science Division, Naval Research Laboratory, Washington, DC 20375 (United States); D’Abrusco, R. [Department of Physical Sciences, University of Napoli Federico II, via Cinthia 9, I-80126 Napoli (Italy); Ricci, F.; La Franca, F. [Dipartimento di Matematica e Fisica, Università Roma Tre, via della Vasca Navale 84, I-00146, Roma (Italy); and others

    2016-04-15

    Blazars, one of the most extreme classes of active galaxies, constitute so far the largest known population of γ-ray sources, and their number is continuously growing in the Fermi catalogs. However, in the latest release of the Fermi catalog there is still a large fraction of sources that are classified as blazar candidates of uncertain type (BCUs) for which optical spectroscopic observations are necessary to confirm their nature and their associations. In addition, about one-third of the γ-ray point sources listed in the Third Fermi-LAT Source Catalog (3FGL) are still unassociated and lacking an assigned lower-energy counterpart. Since 2012 we have been carrying out an optical spectroscopic campaign to observe blazar candidates to confirm their nature. In this paper, the sixth of the series, we present optical spectroscopic observations for 30 γ-ray blazar candidates from different observing programs we carried out with the Telescopio Nazionale Galileo, William Herschel Telescope, Observatorio Astronómico Nacional, Southern Astrophysical Research Telescope, and Magellan Telescopes. We found that 21 out of 30 sources investigated are BL Lac objects, while the remaining targets are classified as flat-spectrum radio quasars showing the typical broad emission lines of normal quasi-stellar objects. We conclude that our selection of γ-ray blazar candidates based on their multifrequency properties continues to be a successful way to discover potential low-energy counterparts of the Fermi unidentified gamma-ray sources and to confirm the nature of BCUs.

  17. GAMMA-RAY EMISSION FROM TWO BLAZARS BEHIND THE GALACTIC PLANE: B2013+370 AND B2023+336

    International Nuclear Information System (INIS)

    Kara, E.; Errando, M.; Aliu, E.; Mukherjee, R.; Max-Moerbeck, W.; Readhead, A. C. S.; Richards, J. L.; Böttcher, M.; Fortin, P.; Halpern, J. P.

    2012-01-01

    B2013+370 and B2023+336 are two blazars at low-galactic latitude that were previously proposed to be the counterparts for the EGRET unidentified sources 3EG J2016+3657 and 3EG J2027+3429. Gamma-ray emission associated with the EGRET sources has been detected by the Fermi Gamma-ray Space Telescope, and the two sources, 1FGL J2015.7+3708 and 1FGL J2027.6+3335, have been classified as unidentified in the 1 year catalog. This analysis of the Fermi Large Area Telescope (LAT) data collected during 31 months reveals that the 1FGL sources are spatially compatible with the blazars and are significantly variable, supporting the hypothesis of extragalactic origin for the gamma-ray emission. The gamma-ray light curves are compared with 15 GHz radio light curves from the 40 m telescope at the Owens Valley Radio Observatory. Simultaneous variability is seen in both bands for the two blazar candidates. The study is completed with the X-ray analysis of 1FGL J2015.7+3708 using Swift observations that were triggered in 2010 August by a Fermi-detected flare. The resulting spectral energy distribution shows a two-component structure typical of blazars. We also identify a second source in the field of view of 1FGL J2027.6+3335 with similar characteristics to the known LAT pulsars. This study gives solid evidence favoring blazar counterparts for these two unidentified EGRET and Fermi sources, supporting the hypothesis that a number of unidentified gamma-ray sources at low-galactic latitudes are indeed of extragalactic origin.

  18. VII Latin American Congress on Biomedical Engineering

    CERN Document Server

    Bustamante, John; Sierra, Daniel

    2017-01-01

    This volume presents the proceedings of the CLAIB 2016, held in Bucaramanga, Santander, Colombia, 26, 27 & 28 October 2016. The proceedings, presented by the Regional Council of Biomedical Engineering for Latin America (CORAL), offer research findings, experiences and activities between institutions and universities to develop Bioengineering, Biomedical Engineering and related sciences. The conferences of the American Congress of Biomedical Engineering are sponsored by the International Federation for Medical and Biological Engineering (IFMBE), Society for Engineering in Biology and Medicine (EMBS) and the Pan American Health Organization (PAHO), among other organizations and international agencies to bring together scientists, academics and biomedical engineers in Latin America and other continents in an environment conducive to exchange and professional growth.

  19. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Skouby, Sven O; Kluft, Cornelis

    2011-01-01

    Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...... alloenzyme with reduced pro-fibrinolytic activity. Presently, we address whether OC use and OC formulation affect FSAP measures in human blood. Healthy women (n=588) were allocated to six cycles of OCs with estrogen contents of 20µg (n=158), 30µg (n=284), 35µg (n=79) or 50µg (n=67) combined with various...... progestins. FSAP genotypes, FSAP and factor VII (FVII) plasma measures were assessed at baseline and after 6 cycles of OC. The 1601GA genotype was present in 49 (8.3%) of the women and was associated with significantly reduced levels of FSAP (P=0.001). OC use increased FSAP antigen by 25% and FSAP activity...

  20. ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, M.B.; Herman, M.; Author(s): Chadwick,M.B.; Herman,M.; Oblozinsky,P.; Dunn,M.E.; Danon,Y.; Kahler,A.C.; Smith,D.L.; Pritychenko,B.; Arbanas,G.; Arcilla,R.; Brewer,R.; Brown,D.A.; Capote,R.; Carlson,A.D.; Cho,Y.S.; Derrien,H.; Guber,K.; Hale,G.M.; Hoblit,S.; Holloway,S.: Johnson,T.D.; Kawano,T.; Kiedrowski,B.C.; Kim,H.; Kunieda,S.; Larson,N.M.; Leal,L.; Lestone,J.P.; Little,R.C.; McCutchan,E.A.; MacFarlane,R.E.; MacInnes,M.; Mattoon,C.M.; McKnight,R.D.; Mughabghab,S.F.; Nobre,G.P.A.; Palmiotti,G.; Palumbo,A.; Pigni,M.T.; Pronyaev,V.G.; Sayer,R.O.; Sonzogni,A.A.; Summers,N.C.; Talou,P.; Thompson,I.J.; Trkov,A.; Vogt,R.L.; van der Marck,S.C.; Wallner,A.; White,M.C.; Wiarda,D.; Young,P.G.

    2011-12-01

    The ENDF/B-VII.1 library is our latest recommended evaluated nuclear data file for use in nuclear science and technology applications, and incorporates advances made in the five years since the release of ENDF/B-VII.0. These advances focus on neutron cross sections, covariances, fission product yields and decay data, and represent work by the US Cross Section Evaluation Working Group (CSEWG) in nuclear data evaluation that utilizes developments in nuclear theory, modeling, simulation, and experiment. The principal advances in the new library are: (1) An increase in the breadth of neutron reaction cross section coverage, extending from 393 nuclides to 423 nuclides; (2) Covariance uncertainty data for 190 of the most important nuclides, as documented in companion papers in this edition; (3) R-matrix analyses of neutron reactions on light nuclei, including isotopes of He, Li, and Be; (4) Resonance parameter analyses at lower energies and statistical high energy reactions for isotopes of Cl, K, Ti, V, Mn, Cr, Ni, Zr and W; (5) Modifications to thermal neutron reactions on fission products (isotopes of Mo, Tc, Rh, Ag, Cs, Nd, Sm, Eu) and neutron absorber materials (Cd, Gd); (6) Improved minor actinide evaluations for isotopes of U, Np, Pu, and Am (we are not making changes to the major actinides {sup 235,238}U and {sup 239}Pu at this point, except for delayed neutron data and covariances, and instead we intend to update them after a further period of research in experiment and theory), and our adoption of JENDL-4.0 evaluations for isotopes of Cm, Bk, Cf, Es, Fm, and some other minor actinides; (7) Fission energy release evaluations; (8) Fission product yield advances for fission-spectrum neutrons and 14 MeV neutrons incident on {sup 239}Pu; and (9) A new decay data sublibrary. Integral validation testing of the ENDF/B-VII.1 library is provided for a variety of quantities: For nuclear criticality, the VII.1 library maintains the generally-good performance seen for VII.0

  1. Time Dependent Leptonic and Lepto-Hadronic Modeling of Blazar Emission

    Science.gov (United States)

    DIltz, Christopher S.

    2016-08-01

    Active galactic nuclei (AGN) are known to exhibit multi-wavelength variability across the whole electromagnetic spectrum. In the context of blazars, the variability timescale can be as short as a few minutes. Correlated variability has been seen in different bands of the electromagnetic spectrum: from radio wavelengths to high energy gamma-rays. This correlated variability in different wavelength bands can put constraints on the particle content, acceleration mechanisms and radiative properties of the relativistic jets that produce blazar emission. Two models are typically invoked to explain the origin of the broadband emission across the electromagnetic spectrum: Leptonic and Hadronic Modeling. Both models have had success in reproducing the broadband spectral energy distributions (SEDs) of blazar emission with different input parameters, making the origin of the emission difficult to determine. However, flaring events cause the spectral components that produce the SED to evolve on different timescales, producing different light curve behavior for both models. My Ph.D. research involves developing one-zone time dependent leptonic and lepto-hadronic codes to reproduce the broadband SEDs of blazars and then model flaring scenarios in order to find distinct differences between the two models. My lepto-hadronic code also considers the time dependent evolution of the radiation emitted by secondary particles (pions and muons) generated from photo-hadronic interactions between the photons and protons in the emission region. I present fits to the broadband SEDs of the flat spectrum radio quasars (FSRQs) 3C 273 and 3C 279 using my one-zone leptonic and lepto-hadronic model, respectively. I showed that by considering perturbations of any one of the selected input parameters for both models: magnetic field, particle injection luminosity, particle spectral index, and stochastic acceleration time scale, distinct differences arise in the light curves for the optical, X-ray and

  2. The Imprint of the Extragalactic Background Light in the Gamma-Ray Spectra of Blazars

    Science.gov (United States)

    Ackermann, M.; Ajello, M.; Allafort, A.; Schady, P.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R; Blandford, R. D.; hide

    2012-01-01

    The light emitted by stars and accreting compact objects through the history of the universe is encoded in the intensity of the extragalactic background light (EBL). Knowledge of the EBL isimportant to understand the nature of star formation and galaxy evolution, but direct measurements of the EBL are limited by galactic and other foreground emissions. Here, we report an absorption feature seen in the combined spectra of a sample of gamma-ray blazars out to a redshift of z approx. 1.6. This feature is caused by attenuation of gamma rays by the EBL at optical to ultraviolet frequencies and allowed us to measure the EBL flux density in this frequency band.

  3. A Comparative Study of Multiwavelength Blazar Variability on Decades to Minutes Timescales

    Directory of Open Access Journals (Sweden)

    Arti Goyal

    2018-03-01

    Full Text Available Multiwavelength blazar variability is produced by noise-like processes with the power-law form of power spectral density (PSD. We present the results of our detailed investigation of multiwavelength ( γ -ray and optical light curves covering decades to minutes timescales, of two BL Lac objects namely, PKS 0735+178 and OJ 287. The PSDs are derived using discrete Fourier transform (DFT method. Our systematic approach reveals that OJ 287 is, on average, more variable than PKS 0735+178 at both optical and γ -ray energies on the corresponding time scales. On timescales shorter than ∼10 days, due to continuous and dense monitoring by the Kepler satellite, a steepening of power spectrum is observed for OJ 287. This indicates the necessity of an intermittent process generating variability on intra-night timescales for OJ 287.

  4. Variations of the Blazar AO 0235+164 in 2006-2015

    Science.gov (United States)

    Hagen-Thorn, V. A.; Larionov, V. M.; Morozova, D. A.; Arkharov, A. A.; Hagen-Thorn, E. I.; Shablovinskaya, E. S.; Prokop'eva, M. S.; Yakovleva, V. A.

    2018-02-01

    The results of optical, radio, and gamma-ray observations of the blazar AO 0235+16 are presented, including photometric ( BV RIJHK) and polarimetric ( R)monitoring carried out at St. Petersburg State University and the Central (Pulkovo) Astronomical Observatory in 2007-2015, 43 GHz Very Long Baseline Interferometry radio observations processed at Boston University, and a gamma-ray light curve based on observationswith the Fermi space observatory are presented. Two strong outbursts were detected. The relative spectral energy distributions of the variable components responsible for the outbursts are determined; these follow power laws, but with different spectral indices. The degree of polarization was high in both outbursts; only an average relationship between the brightness and polarization can be found. There was no time lag between the variations in the optical and gamma-ray, suggesting that the sources of the radiation in the optical and gamma-ray are located in the same region of the jet.

  5. Uudised : Baltimaade suurim, XII "Jazzkaar". VII rahvusvaheline koorifestival. Leipzigis improviseeriti edukalt

    Index Scriptorium Estoniae

    2001-01-01

    23.-29. apr. toimuvast festivalist "Jazzkaar 2001". VII rahvusvahelisest koorifestivalist "Tallinn "2001". 6. ja 7. apr. Leipzigis toimunud V rahvusvahelisest improvisatsioonikonkursist, kus osalesid ka eesti interpreedid

  6. Pengembangan Vaksin Inaktif Tetelo Genotipe VII Isolat Lokal pada Kondisi Laboratorium. (DEVELOPMENT OF TETELO INACTIVATED VACCINE GENOTYPE VII LOCAL ISOLATE IN LABORATORY CONDITION

    Directory of Open Access Journals (Sweden)

    Risa Indriani

    2016-11-01

    Full Text Available Tetelo/Newcastle disease (ND inactive vaccine of genotipe VII virus local isolate have been developedin laboratory condition and compared with commercial ND vaccine. A total of 200 commercial layer chickenat 4 weeks age were divided into four groups, that were (1 vaccinated with ND genotype VII Indonesia/GTT/11, (2 vaccinated with commercial ND vaccine genotype VII, (3 vaccinated with commercial genotypeVI and (4 unvaccinated as control group. After two weeks post vaccination, 10 chicken from each groupwere sellected randomly and challenged with 105 EID50 per 0,1 mL of ND virus genotype VII Indonesian/GTT/11 by intramuscular. Chicken were observed, and swab were collected from oropharyngeal and cloacaat 2, 5, 7, 12 and 14 days post challenge. The result of this study showed inactived vaccine genotype VIIIndonesia/GTT/11 can induced a good antibody titer response to vaccinated chicken with mean titer 7.30log2 and CI 6.3 to 7.8, while commercial ND vaccine genotipe VII was 5.30 log2 with CI 3.8-6.7, andcommercial genotype VI was 4.8 log2 with CI 4.1-5.4. The level of protection which determined by noclinical signs, mortality and viral shedding showed 100% protection in chicken vaccinated with Indonesia/GTT/11 and commercial genotype VII were 100%, compared with control chicken, and vaccined commercialND vaccine genotype VII, compared with control chicken. While in chicken vaccinated commercial NDvaccine genotype VI showed viral shedding on day two post challenge, but there were no clinical sign andmortality. Based on this results, Indonesia/GTT/11 genotype VII ND vaccine could be used as an alternativeND vaccine to protect chicken from infection of ND virus genotype VII in the field.

  7. INVESTIGATING BROADBAND VARIABILITY OF THE TeV BLAZAR 1ES 1959+650

    International Nuclear Information System (INIS)

    Aliu, E.; Archambault, S.; Arlen, T.; Aune, T.; Barnacka, A.; Beilicke, M.; Buckley, J. H.; Bugaev, V.; Benbow, W.; Cerruti, M.; Berger, K.; Bird, R.; Collins-Hughes, E.; Bouvier, A.; Chen, X.; Ciupik, L.; Connolly, M. P.; Cui, W.; Dumm, J.; Eisch, J. D.

    2014-01-01

    We summarize broadband observations of the TeV-emitting blazar 1ES 1959+650, including optical R-band observations by the robotic telescopes Super-LOTIS and iTelescope, UV observations by Swift Ultraviolet and Optical Telescope, X-ray observations by the Swift X-ray Telescope, high-energy gamma-ray observations with the Fermi Large Area Telescope, and very-high-energy (VHE) gamma-ray observations by VERITAS above 315 GeV, all taken between 2012 April 17 and 2012 June 1 (MJD 56034 and 56079). The contemporaneous variability of the broadband spectral energy distribution is explored in the context of a simple synchrotron self Compton (SSC) model. In the SSC emission scenario, we find that the parameters required to represent the high state are significantly different than those in the low state. Motivated by possible evidence of gas in the vicinity of the blazar, we also investigate a reflected emission model to describe the observed variability pattern. This model assumes that the non-thermal emission from the jet is reflected by a nearby cloud of gas, allowing the reflected emission to re-enter the blob and produce an elevated gamma-ray state with no simultaneous elevated synchrotron flux. The model applied here, although not required to explain the observed variability pattern, represents one possible scenario which can describe the observations. As applied to an elevated VHE state of 66% of the Crab Nebula flux, observed on a single night during the observation period, the reflected emission scenario does not support a purely leptonic non-thermal emission mechanism. The reflected emission model does, however, predict a reflected photon field with sufficient energy to enable elevated gamma-ray emission via pion production with protons of energies between 10 and 100 TeV

  8. Constraining the Location of Gamma-Ray Flares in Luminous Blazars

    Science.gov (United States)

    Nalewajko, Krzysztof; Begelman, Mitchell C.; Sikora, Marek

    2014-07-01

    Locating the gamma-ray emission sites in blazar jets is a long standing and highly controversial issue. We jointly investigate several constraints on the distance scale r and Lorentz factor Γ of the gamma-ray emitting regions in luminous blazars (primarily flat spectrum radio quasars). Working in the framework of one-zone external radiation Comptonization models, we perform a parameter space study for several representative cases of actual gamma-ray flares in their multiwavelength context. We find a particularly useful combination of three constraints: from an upper limit on the collimation parameter Γθ ~ 0.1-0.7. Typical values of r corresponding to moderate values of Γ ~ 20 are in the range 0.1-1 pc, and are determined primarily by the observed variability timescale t var, obs. Alternative scenarios motivated by the observed gamma-ray/millimeter connection, in which gamma-ray flares of t var, obs ~ a few days are located at r ~ 10 pc, are in conflict with both the SSC and cooling constraints. Moreover, we use a simple light travel time argument to point out that the gamma-ray/millimeter connection does not provide a significant constraint on the location of gamma-ray flares. We argue that spine-sheath models of the jet structure do not offer a plausible alternative to external radiation fields at large distances; however, an extended broad-line region is an idea worth exploring. We propose that the most definite additional constraint could be provided by determination of the synchrotron self-absorption frequency for correlated synchrotron and gamma-ray flares.

  9. Modeling Broadband Variability of Blazars with Time-Dependent Multi-Zone Radiative Transfer Simulations

    Science.gov (United States)

    Fossati, Giovanni

    This proposal aims at fully exploiting the large body of X-ray and multiwavelength observational data on TeV gamma-ray bright blazars for a detailed comparison with state- of-the art blazar radiation transfer simulations. The aim of this investigation is to develop diagnostics on critical jet parameters and shock physics, such as the magnetic field, the kinetic energy content in the jets, the characteristics of the shock acceleration mechanisms, and the detailed influence on geometry on the observed spectral variability features. Our project will comprises a systematic, uniform re-analysis of the relevant (in particular, X-ray) data sets. We will extract time-dependent spectral energy distributions, light curves, and intra-band as well as inter-band time lags from the available data. The modeling tasks will start with a quick sweep through parameter space using a semi- analytical internal-shock model. This will help to narrow down parameters such as the Lorentz factors of interacting emission regions, the overall energy requirements, the characteristics of the electron distributions accelerated at internal shocks, and the magnetic field. The parameters of this semi-analytical internal-shock model that allow for a representation of time-dependent SEDs, light curves and inter-band time lags, will form the starting point for our detailed modeling using our state-of-the-art time-dependent multi-zone Monte-Carlo simulation code. Using that code, we will explore in more detail the characteristics of the particle acceleration in active regions and the influence of various geometries on the observable features. By capitalizing on archival data of several NASA space astrophysics missions our proposal is in agreement with the NASA ADAP research objective, "the analysis io NASA space astrophysics data that are archived in the public domain at the time of submission", as stated in the NASA Research announcement.

  10. The extreme blazar AO 0235+164 as seen by extensive ground and space radio observations

    Science.gov (United States)

    Kutkin, A. M.; Pashchenko, I. N.; Lisakov, M. M.; Voytsik, P. A.; Sokolovsky, K. V.; Kovalev, Y. Y.; Lobanov, A. P.; Ipatov, A. V.; Aller, M. F.; Aller, H. D.; Lahteenmaki, A.; Tornikoski, M.; Gurvits, L. I.

    2018-04-01

    Clues to the physical conditions in radio cores of blazars come from measurements of brightness temperatures as well as effects produced by intrinsic opacity. We study the properties of the ultra-compact blazar AO 0235+164 with RadioAstron ground-space radio interferometer, multifrequency VLBA, EVN, and single-dish radio observations. We employ visibility modelling and image stacking for deriving structure and kinematics of the source, and use Gaussian process regression to find the relative multiband time delays of the flares. The multifrequency core size and time lags support prevailing synchrotron self-absorption. The intrinsic brightness temperature of the core derived from ground-based very long baseline interferometry (VLBI) is close to the equipartition regime value. In the same time, there is evidence for ultra-compact features of the size of less than 10 μas in the source, which might be responsible for the extreme apparent brightness temperatures of up to 1014 K as measured by RadioAstron. In 2007-2016 the VLBI components in the source at 43 GHz are found predominantly in two directions, suggesting a bend of the outflow from southern to northern direction. The apparent opening angle of the jet seen in the stacked image at 43 GHz is two times wider than that at 15 GHz, indicating a collimation of the flow within the central 1.5 mas. We estimate the Lorentz factor Γ = 14, the Doppler factor δ = 21, and the viewing angle θ = 1.7° of the apparent jet base, derive the gradients of magnetic field strength and electron density in the outflow, and the distance between jet apex and the core at each frequency.

  11. Extremely Rapid X-Ray Flares of TeV Blazars in the RXTE Era

    Science.gov (United States)

    Zhu, S. F.; Xue, Y. Q.; Brandt, W. N.; Cui, W.; Wang, Y. J.

    2018-01-01

    Rapid flares from blazars in very high-energy (VHE) γ-rays challenge the common understanding of jets of active galactic nuclei (AGNs). The same population of ultra-relativistic electrons is often thought to be responsible for both X-ray and VHE emission. We thus systematically searched for X-ray flares at sub-hour timescales of TeV blazars in the entire Rossi X-ray Timing Explorer archival database. We found rapid flares from PKS 2005‑489 and S5 0716+714, and a candidate rapid flare from 1ES 1101‑232. In particular, the characteristic rise timescale of PKS 2005‑489 is less than half a minute, which, to our knowledge, is the shortest among known AGN flares at any wavelengths. The timescales of these rapid flares indicate that the size of the central supermassive black hole is not a hard lower limit on the physical size of the emission region of the flare. PKS 2005‑489 shows possible hard lags in its flare, which could be attributed to particle acceleration (injection); its flaring component has the hardest spectrum when it first appears. For all flares, the flaring components show similar hard spectra with {{Γ }}=1.7{--}1.9, and we estimate the magnetic field strength B ∼ 0.1–1.0 G by assuming synchrotron cooling. These flares could be caused by inhomogeneity of the jets. Models that can only produce rapid γ-ray flares but little synchrotron activity are less favorable.

  12. Synthesis and characterization of 18F-labeled active site inhibited factor VII (ASIS)

    DEFF Research Database (Denmark)

    Erlandsson, Maria; Nielsen, Carsten Haagen; Jeppesen, Troels Elmer

    2015-01-01

    column. The radiochemical yield was 25 ± 6%, the radiochemical purity was >97%, and the pseudospecific radioactivity was 35 ± 9 GBq/µmol. The binding efficacy was evaluated in pull-down experiments, which monitored the binding of unlabeled ASIS and [18F]ASIS to TF and to a specific anti-factor VII...... antibody (F1A2-mAb). No significant difference in binding efficacy between [18F]ASIS and ASIS could be detected. Furthermore, [18F]ASIS was relatively stable in vitro and in vivo in mice. In conclusion, [18F]ASIS has for the first time been successfully synthesized as a possible positron emission...

  13. Benchmarking ENDF/B-VII.1, JENDL-4.0 and JEFF-3.1

    International Nuclear Information System (INIS)

    Van Der Marck, S. C.

    2012-01-01

    Three nuclear data libraries have been tested extensively using criticality safety benchmark calculations. The three libraries are the new release of the US library ENDF/B-VII.1 (2011), the new release of the Japanese library JENDL-4.0 (2011), and the OECD/NEA library JEFF-3.1 (2006). All calculations were performed with the continuous-energy Monte Carlo code MCNP (version 4C3, as well as version 6-beta1). Around 2000 benchmark cases from the International Handbook of Criticality Safety Benchmark Experiments (ICSBEP) were used. The results were analyzed per ICSBEP category, and per element. Overall, the three libraries show similar performance on most criticality safety benchmarks. The largest differences are probably caused by elements such as Be, C, Fe, Zr, W. (authors)

  14. Weighted oscillator strengths and lifetimes for the S VII spectrum

    International Nuclear Information System (INIS)

    Borges, F.O.; Cavalcanti, G.H.; Trigueiros, A.G.; Jupen, C.

    2004-01-01

    The weighted oscillator strengths (gf) and the lifetimes presented in this work were carried out in a multiconfiguration Hartree-Fock relativistic approach. In this calculation, the electrostatic parameters were optimized by a least-squares procedure, in order to improve the adjustment to experimental energy levels. This method produces gf-values that are in better agreement with intensity observations and lifetime values that are closer to the experimental ones. In this work, we presented all the experimentally known electric dipole S VII spectral lines

  15. Search for High-Confidence Blazar Candidates and Their MWL Counterparts in the Fermi-LAT Catalog Using Machine Learning

    Directory of Open Access Journals (Sweden)

    Sabrina Einecke

    2016-08-01

    Full Text Available A large fraction of the gamma-ray sources presented in the Third Fermi-LAT source catalog (3FGL is affiliated with counterparts and source types, but 1010 sources remain unassociated and 573 sources are associated with active galaxies of uncertain type. The purpose of this study is to assign blazar classes to these unassociated and uncertain sources, and to link counterparts to the unassociated. A machine learning algorithm is used for the classification, based on properties extracted from the 3FGL, an infrared and an X-ray catalog. To estimate the reliability of the classification, performance measures are considered through validation techniques. The classification yielded purity values around 90% with efficiency values of roughly 50%. The prediction of high-confidence blazar candidates has been conducted successfully, and the possibility to link counterparts in the same procedure has been proven. These findings confirm the relevance of this novel multiwavelength approach.

  16. Separation of Rhenium (VII) and Vanadium(V) from concentrated HCI solution by solvent extraction with Alamine 336 and LIX 63

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Ji-Won; Lee, Man-Seung [Mokpo National University, Mokpo (Korea, Republic of)

    2017-01-15

    Solvent extraction experiments were performed with Re(VII) and V(V) from concentrated HCl solutions. In this work, Alamine 336 and LIX 63 were employed as the basic and cationic extractants. At an HCl concentration range from 1 to 5 M, Re(VII) was selectively extracted by Alamine 336, while V(V) was selectively extracted by LIX 63. A low HCl concentration was favorable for separating the two metals by solvent extraction. Although an alkaline solution can completely strip both Re(VII) and V(V) from loaded Alamine 336 and LIX 63, it was difficult to separate the two metals by stripping. However, it was found that an HCl solution could selectively strip the metal with a low extraction percentage from the loaded Alamine 336 and LIX 63, and thus separation of the two metals was achieved. Our data can be utilized to develop a process for separating Re(VII) and V(V) from concentrated HCl solutions.

  17. ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, M. B. [Los Alamos National Laboratory (LANL); Herman, Micheal W [Brookhaven National Laboratory (BNL); Oblozinsky, Pavel [Brookhaven National Laboratory (BNL); Dunn, Michael E [ORNL; Danon, Y. [Rensselaer Polytechnic Institute (RPI); Kahler, A. [Los Alamos National Laboratory (LANL); Smith, Donald L. [Argonne National Laboratory (ANL); Pritychenko, B [Brookhaven National Laboratory (BNL); Arbanas, Goran [ORNL; Arcilla, r [Brookhaven National Laboratory (BNL); Brewer, R [Los Alamos National Laboratory (LANL); Brown, D A [Brookhaven National Laboratory (BNL); Capote, R. [International Atomic Energy Agency (IAEA); Carlson, A. D. [National Institute of Standards and Technology (NIST); Cho, Y S [Korea Atomic Energy Research Institute; Derrien, Herve [ORNL; Guber, Klaus H [ORNL; Hale, G. M. [Los Alamos National Laboratory (LANL); Hoblit, S [Brookhaven National Laboratory (BNL); Holloway, Shannon T. [Los Alamos National Laboratory (LANL); Johnson, T D [Brookhaven National Laboratory (BNL); Kawano, T. [Los Alamos National Laboratory (LANL); Kiedrowski, B C [Los Alamos National Laboratory (LANL); Kim, H [Korea Atomic Energy Research Institute; Kunieda, S [Los Alamos National Laboratory (LANL); Larson, Nancy M [ORNL; Leal, Luiz C [ORNL; Lestone, J P [Los Alamos National Laboratory (LANL); Little, R C [Los Alamos National Laboratory (LANL); Mccutchan, E A [Brookhaven National Laboratory (BNL); Macfarlane, R E [Los Alamos National Laboratory (LANL); MacInnes, M [Los Alamos National Laboratory (LANL); Matton, C M [Lawrence Livermore National Laboratory (LLNL); Mcknight, R D [Argonne National Laboratory (ANL); Mughabghab, S F [Brookhaven National Laboratory (BNL); Nobre, G P [Brookhaven National Laboratory (BNL); Palmiotti, G [Idaho National Laboratory (INL); Palumbo, A [Brookhaven National Laboratory (BNL); Pigni, Marco T [ORNL; Pronyaev, V. G. [Institute of Physics and Power Engineering (IPPE), Obninsk, Russia; Sayer, Royce O [ORNL; Sonzogni, A A [Brookhaven National Laboratory (BNL); Summers, N C [Lawrence Livermore National Laboratory (LLNL); Talou, P [Los Alamos National Laboratory (LANL); Thompson, I J [Lawrence Livermore National Laboratory (LLNL); Trkov, A. [Jozef Stefan Institute, Slovenia; Vogt, R L [Lawrence Livermore National Laboratory (LLNL); Van der Marck, S S [Nucl Res & Consultancy Grp, Petten, Netherlands; Wallner, A [University of Vienna, Austria; White, M C [Los Alamos National Laboratory (LANL); Wiarda, Dorothea [ORNL; Young, P C [Los Alamos National Laboratory (LANL)

    2011-01-01

    The ENDF/B-VII.1 library is our latest recommended evaluated nuclear data file for use in nuclear science and technology applications, and incorporates advances made in the five years since the release of ENDF/B-VII.0. These advances focus on neutron cross sections, covariances, fission product yields and decay data, and represent work by the US Cross Section Evaluation Working Group (CSEWG) in nuclear data evaluation that utilizes developments in nuclear theory, modeling, simulation, and experiment. The principal advances in the new library are: (1) An increase in the breadth of neutron reaction cross section coverage, extending from 393 nuclides to 423 nuclides; (2) Covariance uncertainty data for 190 of the most important nuclides, as documented in companion papers in this edition; (3) R-matrix analyses of neutron reactions on light nuclei, including isotopes of He; Li, and Be; (4) Resonance parameter analyses at lower energies and statistical high energy reactions for isotopes of Cl; K; Ti, V, Mn, Cr, Ni, Zr and W; (5) Modifications to thermal neutron reactions on fission products (isotopes of Mo, Tc, Rh, Ag, Cs, Nd, Sm, Eu) and neutron absorber materials (Cd, Gd); (6) Improved minor actinide evaluations for isotopes of U, Np, Pu, and Am (we are not making changes to the major actinides (235,238)U and (239)Pu at this point, except for delayed neutron data and covariances, and instead we intend to update them after a further period of research in experiment and theory), and our adoption of JENDL-4.0 evaluations for isotopes of Cm, Bk, Cf, Es; Fm; and some other minor actinides; (7) Fission energy release evaluations; (8) Fission product yield advances for fission-spectrum neutrons and 14 MeV neutrons incident on (239)Pu; and (9) A new decay data sublibrary. Integral validation testing of the ENDF/B-VII.1 library is provided for a variety of quantities: For nuclear criticality, the VII.1 library maintains the generally-good performance seen for VII.0 for a wide

  18. Long-Term Monitoring of Bright Blazars in the Multi-GeV to TeV Range with FACT

    Directory of Open Access Journals (Sweden)

    Fabian Temme

    2017-02-01

    Full Text Available Blazars like Markarian 421 or Markarian 501 are active galactic nuclei (AGN, with their jets orientated towards the observer. They are among the brightest objects in the very high energy (VHE gamma ray regime (>100 GeV. Their emitted gamma-ray fluxes are extremely variable, with changing activity levels on timescales between minutes, months, and even years. Several questions are part of the current research, such as the question of the emission regions or the engine of the AGN and the particle acceleration. A dedicated longterm monitoring program is necessary to investigate the properties of blazars in detail. A densely sampled and unbiased light curve allows for observation of both high and low states of the sources, and the combination with multi-wavelength observation could contribute to the answer of several questions mentioned above. FACT (First G-APD Cherenkov Telescope is the first operational telescope using silicon photomultiplier (SiPM, also known as Geigermode—Avalanche Photo Diode, G-APD as photon detectors. SiPM have a very homogenous and stable longterm performance, and allow operation even during full moon without any filter, leading to a maximal duty cycle for an Imaging Air Cherenkov Telescope (IACT. Hence, FACT is an ideal device for such a longterm monitoring of bright blazars. A small set of sources (e.g., Markarian 421, Markarian 501, 1ES 1959+650, and 1ES 2344+51.4 is currently being monitored. In this contribution, the FACT telescope and the concept of longterm monitoring of bright blazars will be introduced. The results of the monitoring program will be shown, and the advantages of densely sampled and unbiased light curves will be discussed.

  19. Evaluated Nuclear Data Covariances: The Journey From ENDF/B-VII.0 to ENDF/B-VII.1

    International Nuclear Information System (INIS)

    Smith, Donald L.

    2011-01-01

    Recent interest from data users on applications that utilize the uncertainties of evaluated nuclear reaction data has stimulated the data evaluation community to focus on producing covariance data to a far greater extent than ever before. Although some uncertainty information has been available in the ENDF/B libraries since the 1970's, this content has been fairly limited in scope, the quality quite variable, and the use of covariance data confined to only a few application areas. Today, covariance data are more widely and extensively utilized than ever before in neutron dosimetry, in advanced fission reactor design studies, in nuclear criticality safety assessments, in national security applications, and even in certain fusion energy applications. The main problem that now faces the ENDF/B evaluator community is that of providing covariances that are adequate both in quantity and quality to meet the requirements of contemporary nuclear data users in a timely manner. In broad terms, the approach pursued during the past several years has been to purge any legacy covariance information contained in ENDF/B-VI.8 that was judged to be subpar, to include in ENDF/B-VII.0 (released in 2006) only those covariance data deemed then to be of reasonable quality for contemporary applications, and to subsequently devote as much effort as the available time and resources allowed to producing additional covariance data of suitable scope and quality for inclusion in ENDF/B-VII.1. Considerable attention has also been devoted during the five years since the release of ENDF/B-VII.0 to examining and improving the methods used to produce covariance data from thermal energies up to the highest energies addressed in the ENDF/B library, to processing these data in a robust fashion so that they can be utilized readily in contemporary nuclear applications, and to developing convenient covariance data visualization capabilities. Other papers included in this issue discuss in considerable

  20. Methods for Processing ENDF/B-VII with NJOY

    Science.gov (United States)

    MacFarlane, R. E.; Kahler, A. C.

    2010-12-01

    The NJOY Nuclear Data Processing System is widely used to convert evaluations in the Evaluated Nuclear Data Files (ENDF) format into forms useful for practical applications such as fission and fusion reactor analysis, stockpile stewardship calculations, criticality safety, radiation shielding, nuclear waste management, nuclear medicine procedures, and more. This paper provides a description of the system's capabilities, summary descriptions of the methods used, and information on how to use the code to process the modern evaluated nuclear data files from ENDF/B-VII. It begins with the generation of pointwise libraries, including reaction and resonance reconstruction, Doppler broadening, radiation heating and damage, thermal scattering data, unresolved resonance data, and gas production. It then reviews the production of libraries for the continuous-energy Monte Carlo code MCNP, multigroup neutron, photon, and particle cross sections and matrices, and photon interaction data. The generation of uncertainty information for ENDF data is discussed, including new capabilities for calculating covariances of resonance data, angular distributions, energy distributions, and radioactive nuclide production. NJOY's ability to prepare thermal scattering data evaluations for bound moderators (which was used during the preparation of the ENDF/B-VII library) is described. The strong plotting capabilities of NJOY are summarized. Many examples of black&white and color Postscript plots are included throughout the paper. The capabilities of NJOY to output multigroup data in several different formats to suit various applications is reviewed. Finally, a section is included that summarizes the history of the development of the NJOY system over the last 37 years.

  1. Endf/B-VII.0 Based Library for Paragon - 313

    International Nuclear Information System (INIS)

    Huria, H.C.; Kucukboyaci, V.N.; Ouisloumen, M.

    2010-01-01

    A new 70-group library has been generated for the Westinghouse lattice physics code PARAGON using the ENDF/B-VII.0 nuclear data files. The new library retains the major features of the current library, including the number of energy groups and the reduction in the U-238 resonance integral. The upper bound for the up-scattering effects in the new library, however, has been moved to 4.0 eV from 2.1 eV for better MOX fuel predictions. The new library has been used to analyze standard benchmarks and also to compare the measured and predicted parameters for different types of Westinghouse and Combustion Engineering (CE) type operating reactor cores. Results indicate that the new library will not impact the reactivity, power distribution and the temperature coefficient predictions over a wide range of physics design parameters; however, will improve the MOX core predictions. In other words, the ENDF/B-VI.3 and ENDF/B-VII.0 produce similar results for reactor core calculations. (authors)

  2. BEIR VII: What's old, What's new, and What challenges remain?

    International Nuclear Information System (INIS)

    Douple, E.; Jostes, R.

    2007-01-01

    The Biological Effects of Ionizing Radiation (BEIR VII) Committee reviewed evidence since the 1990 BEIR V report and developed BEIR VII risk estimates, including a linear, no-threshold dose-response relationship between exposure to ionizing radiation and the development of cancer in humans for exposures up to 0.1 Sv, quantifying the lifetime risks for both cancer mortality and incidence as a function of age at exposure and sex, primarily based on the Japanese atomic-bomb survivor data. If 100 people with an age distribution typical of the U.S. population receive an acute exposure of 0.1 Sv, one person would be expected to eventually develop cancer from this exposure, while 42 of the 100 people would be expected to develop cancer from other causes. The committee estimated the risk following radiation exposure for both incidence and mortality for 11 specific cancer sites. The total risk of heritable genetic diseases from parents exposed prior to conception was 3,000 to 4,700 cases per million progeny per Sv, 0.4-0.6% compared to an estimated baseline risk of 738,000 cases per million. Noncancer diseases such as cardiovascular disease can result from exposures to high doses of radiation, but the data available at this time are not sufficient to develop reliable estimates of risk for these noncancer outcomes at low doses of radiation. Twelve specific recommendations were presented as needs for future research. (author)

  3. Implications of variability Patterns Observed in TeV Blazars on the Structure of the Inner Jet

    Energy Technology Data Exchange (ETDEWEB)

    Madejski, Grzegorz

    2003-03-18

    The recent long look X-ray observations of TeV blazars have revealed many important new features concerning their time variability. In this paper, we suggest a physical interpretation for those features based on the framework of the internal and external shock scenarios. We present a simplified model applicable to TeV blazars, and investigate through simulations how each of the model parameters would affect to the observed light curve or spectrum. In particular, we show that the internal shock scenario naturally leads to all the observed variability properties including the structure function, but for it to be applicable, the fractional fluctuation of the initial bulk Lorentz factors must be small, {sigma}{prime}{sub {Lambda}} {triple_bond} {sigma}{sub {Lambda}}/{Lambda}{sub avrg} << 0.01. This implies very low dynamical efficiency of the internal shock scenario. We also suggest that several observational quantities--such as the characteristic time scale, the relative amplitude of flares as compared to the steady (''offset'') component, and the slope of the structure function--can be used to probe the inner jet. The results are applied to the TeV blazar Mrk 421, and this, within the context of the model, leads to the determination of several physical parameters: the ejection of a shell with average thickness of {approx} 10{sup 13} cm occurs on average every 10 minutes, and the shells collide {approx} 10{sup 17} cm away from the central source.

  4. Constraints on the Location of γ-Ray Sample of Blazars with Radio Core-shift Measurements

    Science.gov (United States)

    Wu, Linhui; Wu, Qingwen; Yan, Dahai; Chen, Liang; Fan, Xuliang

    2018-01-01

    We model simultaneous or quasi-simultaneous multi-band spectral energy distributions (SEDs) for a sample of 25 blazars that have radio core-shift measurements, where a one-zone leptonic model and Markov chain Monte Carlo technique are adopted. In the SED fitting for 23 low-synchrotron-peaked (LSP) blazars, the seed photons from the broad-line (BLR) and molecular torus are considered respectively in the external Compton process. We find that the SED fitting with the seed photons from the torus are better than those utilizing BLR photons, which suggest that the γ-ray emitting region may be located outside the BLR. Assuming the magnetic field strength in the γ-ray emitting region as constrained from the SED fitting follows the magnetic field distribution as derived from the radio core-shift measurements (i.e., B{(R)≃ {B}1{pc}(R/1{pc})}-1, where R is the distance from the central engine and {B}1{pc} is the magnetic field strength at 1 pc), we further calculate the location of the γ-ray emitting region, {R}γ , for these blazars. We find that {R}γ ∼ 2× {10}4{R}{{S}}≃ 10 {R}{BLR} ({R}{{S}} is the Schwarzschild radius and {R}{BLR} is the BLR size), where {R}{BLR} is estimated from the broad-line luminosities using the empirical correlations obtained using the reverberation mapping methods.

  5. 76 FR 57013 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2011-09-15

    ... EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1602 RIN 3046-AA89 Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA AGENCY: Equal Employment Opportunity Commission. ACTION... under title VII, the ADA, and GINA. (76 FR 31892, June 2, 2011). No requests to present oral testimony...

  6. Group VII Ethylene Response Factor diversification and regulation in four species from flood-prone environments.

    NARCIS (Netherlands)

    Veen, van H.; Akman, M.; Jamar, D.C.L.; Vreugdenhil, D.; Kooiker, M.; Tienderen, van P.H.; Voesenek, L.A.C.J.; Schranz, M.E.; Sasidharan, R.

    2014-01-01

    Flooding events negatively affect plant performance and survival. Flooding gradients thereby determine the dynamics in vegetation composition and species abundance. In adaptation to flooding, the group VII Ethylene Response Factor genes (ERF-VIIs) play pivotal roles in rice and Arabidopsis through

  7. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo

    DEFF Research Database (Denmark)

    Sidelmann, Johannes Jakobsen; Skouby, Sven O.; Kluft, Cornelis

    2011-01-01

    Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...... alloenzyme with reduced pro-fibrinolytic activity. Presently, we address whether OC use and OC formulation affect FSAP measures in human blood. Healthy women (n=588) were allocated to six cycles of OCs with estrogen contents of 20μg (n=158), 30μg (n=284), 35μg (n=79) or 50μg (n=67) combined with various...... progestins. FSAP genotypes, FSAP and factor VII (FVII) plasma measures were assessed at baseline and after 6 cycles of OC. The 1601GA genotype was present in 49 (8.3%) of the women and was associated with significantly reduced levels of FSAP (P≤0.001). OC use increased FSAP antigen by 25% and FSAP activity...

  8. The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns.

    Science.gov (United States)

    Quek, S C; Low, P S; Saha, N; Heng, C K

    2006-11-01

    Factor VII (FVII) is an independent risk factor for coronary artery disease. Three polymorphisms of the factor VII gene (F7) were studied in a group of healthy newborns comprising 561 Chinese, 398 Malays and 226 Asian Indians from Singapore. The allele frequencies of 3 polymorphisms (R353Q, Promoter 0/10bp Del/Ins and Intron 7) in the FVII gene were ascertained through genotyping by polymerase chain reaction and restriction digestion of amplified fragments. In Chinese the minor allele frequencies are Q: 0.04, Ins: 0.03, R7: 0.44; Malays, Q: 0.06, Ins: 0.10, R7: 0.41; and Indians, Q: 0.25, Ins: 0.23, R7: 0.43. Strong linkage disequilibrium (Delta > 0.7) is observed between the 0/10 bp and the R353Q sites in all ethnic groups. We conclude that: (i) the prevalence of the minor Q and Ins alleles of the R353Q and 0/10 bp polymorphisms are significantly higher in the Indian newborns than the Chinese and Malays; (ii) the Q allele is significantly associated (p = 0.01) with a lower plasma FVII coagulant level in the Indian and Malay neonates; and this polymorphism explains up to 3.8% of the variance in FVII coagulant levels; (iii) there is no significant difference in allele frequencies of the three polymorphisms between neonates with and without family histories of CAD.

  9. Phase VII update (1984) report for the Energy Economic Data Program EEDB-VII

    International Nuclear Information System (INIS)

    1985-08-01

    Objective of the Energy Economic Data Base (EEDB) Program is to provide current, representative and consistent power plant technical and cost information to the US Department of Energy (DOE). These data are useful for program planning by the Office of the Assistant Secretary for Nuclear Energy, because they are representative of current US power plant construction cost experience and are developed on a consistent, organized basis

  10. A Case of Aplasia Cutis Congenita, Type VII

    Science.gov (United States)

    Lee, Joung Sun; Lee, Jee Bum; Kim, Seong Jin; Won, Young Ho

    2008-01-01

    Aplasia cutis congenita (ACC) is a rare congenital defect in which localized or widespread areas of the skin are absent at birth. In the majority of cases, it is limited to the scalp especially on the vertex although other areas of the body may also be involved. Other congenital malformations can be associated with ACC. We present herein the case of a new born male with unilateral absence of skin on the extensor surface of the right lower leg. There was no associated malformation or skin disease such as blistering or nail abnormailty. According to the classification outlined by Frieden, the condition was diagnosed as type VII aplasia cutis congenita. The treatment of this large ulcer was conservative, wet dressing and prophylactic topical antibiotics. On follow up after 2 years showed that the patient was nearly cured of the ulcer and had only minimal scar formation. PMID:27303163

  11. Convenient synthesis of bis(alkoxy)rhenium(VII) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Z.; Al-Ajlouni, A.M.; Espenson, J.H. [Iowa State Univ., Ames, IA (United States)

    1996-02-28

    The study of high-oxidation-state organorhenium compounds has been a field of continuing activity, thanks to the success of methylrhenium trioxide (CH{sub 3}ReO{sub 3} or MTO) in catalytic processes. This catalyst is effective in oxidations, olefin metathesis, the olefination of aldehydes, and the preparation of other compounds with three-membered rings. The syntheses of some rhenium compounds derived form MTO have been reported. Epoxide formation is a key reaction, and it bears directly on these findings reported here. Re(VII) complexes containing a chelated bis(diolate) ligand can be synthesized by refluxing MTO with 2,3-dimethyl-2,3-diol. Here, the authors report a more convenient method for this preparation. A different series of related compounds consists of chelated bis(diolates) of the Cp*Re-oxo series, Cp*ReO-(diolate).

  12. Constraining the location of gamma-ray flares in luminous blazars

    Energy Technology Data Exchange (ETDEWEB)

    Nalewajko, Krzysztof; Begelman, Mitchell C. [JILA, University of Colorado and National Institute of Standards and Technology, 440 UCB, Boulder, CO 80309 (United States); Sikora, Marek, E-mail: knalew@jila.colorado.edu [Nicolaus Copernicus Astronomical Center, Bartycka 18, 00-716 Warsaw (Poland)

    2014-07-10

    Locating the gamma-ray emission sites in blazar jets is a long standing and highly controversial issue. We jointly investigate several constraints on the distance scale r and Lorentz factor Γ of the gamma-ray emitting regions in luminous blazars (primarily flat spectrum radio quasars). Working in the framework of one-zone external radiation Comptonization models, we perform a parameter space study for several representative cases of actual gamma-ray flares in their multiwavelength context. We find a particularly useful combination of three constraints: from an upper limit on the collimation parameter Γθ ≲ 1, from an upper limit on the synchrotron self-Compton (SSC) luminosity L{sub SSC} ≲ L{sub X}, and from an upper limit on the efficient cooling photon energy E{sub cool,obs} ≲ 100 MeV. These three constraints are particularly strong for sources with low accretion disk luminosity L{sub d}. The commonly used intrinsic pair-production opacity constraint on Γ is usually much weaker than the SSC constraint. The SSC and cooling constraints provide a robust lower limit on the collimation parameter Γθ ≳ 0.1-0.7. Typical values of r corresponding to moderate values of Γ ∼ 20 are in the range 0.1-1 pc, and are determined primarily by the observed variability timescale t{sub var,obs}. Alternative scenarios motivated by the observed gamma-ray/millimeter connection, in which gamma-ray flares of t{sub var,obs} ∼ a few days are located at r ∼ 10 pc, are in conflict with both the SSC and cooling constraints. Moreover, we use a simple light travel time argument to point out that the gamma-ray/millimeter connection does not provide a significant constraint on the location of gamma-ray flares. We argue that spine-sheath models of the jet structure do not offer a plausible alternative to external radiation fields at large distances; however, an extended broad-line region is an idea worth exploring. We propose that the most definite additional constraint could be

  13. Fine Structure of the Core of the Blazar OJ 287-I

    Science.gov (United States)

    Matveyenko, L. I.; Sivakon', S. S.

    2017-12-01

    The fine structure of the active region, the bulge, of the blazar OJ 287 has been investigated with a resolution of 20 μas (0.1 pc) at a wavelength of 7 mm, the epochs of 2007-2017. The structure and kinematics correspond to a vortex nature. The surrounding matter, the plasma, is transferred to the center along two arms from opposite directions. The emerging excess angular momentum is carried away along the rotation axis by bipolar outflows, rotating coaxial tubes, in a direction X ≈ -120° in the plane of the sky as it is accumulated. The central high-velocity bipolar outflow has a helical shape. The diameters of the low-velocity flows are ø1 ≈ 0.3 and ø2 ≈ 0.65 mas, or 1.4 and 3 pc, respectively. Ring currents whose tangential directions are observed as parallel chains of components are excited in the flow walls. The peak brightness temperature of the nozzle reaches Tb ≈ 1012-1013 K. A "disk" with a diameter ø ≈ 0.5 mas (≈2.2 pc) is observed by the absorption of synchrotron radiation. The disk is inclined to the plane of the sky at an angle of 60° in the jet direction. The fragments are seen from a distance of ˜0.2 mas outside the absorption zone. The jet sizes exceed considerably the counterjet ones. An enhanced supply of plasma from the northern arm gives rise to an independent vortex 0.2 mas away from the central one in the NW direction. As in the first case, the helical central bipolar outflow is surrounded by a low-velocity component ø ≈ 0.28 mas in diameter with built-in ring currents. The jet is ejected in the direction X = -50° in the plane of the sky. The jet orientation changes, X = -130° at a distance of 1 mas. A high activity of the central and two side nozzles spaced 0.22 mas apart in the direction X = -40° is occasionally observed simultaneously. The active region of the blazar is observed through an ionized medium, a screen, whose influence is significant even at a wavelength of 7 mm. The absorption and refraction of the

  14. The WEBT Campaign on the Blazar 3C 279 in 2006

    Science.gov (United States)

    Böttcher, M.; Basu, S.; Joshi, M.; Villata, M.; Arai, A.; Aryan, N.; Asfandiyarov, I. M.; Bach, U.; Bachev, R.; Berduygin, A.; Blaek, M.; Buemi, C.; Castro-Tirado, A. J.; De Ugarte Postigo, A.; Frasca, A.; Fuhrmann, L.; Hagen-Thorn, V. A.; Henson, G.; Hovatta, T.; Hudec, R.; Ibrahimov, M.; Ishii, Y.; Ivanidze, R.; Jelínek, M.; Kamada, M.; Kapanadze, B.; Katsuura, M.; Kotaka, D.; Kovalev, Y. Y.; Kovalev, Yu. A.; Kubánek, P.; Kurosaki, M.; Kurtanidze, O.; Lähteenmäki, A.; Lanteri, L.; Larionov, V. M.; Larionova, L.; Lee, C.-U.; Leto, P.; Lindfors, E.; Marilli, E.; Marshall, K.; Miller, H. R.; Mingaliev, M. G.; Mirabal, N.; Mizoguchi, S.; Nakamura, K.; Nieppola, E.; Nikolashvili, M.; Nilsson, K.; Nishiyama, S.; Ohlert, J.; Osterman, M. A.; Pak, S.; Pasanen, M.; Peters, C. S.; Pursimo, T.; Raiteri, C. M.; Robertson, J.; Robertson, T.; Ryle, W. T.; Sadakane, K.; Sadun, A.; Sigua, L.; Sohn, B.-W.; Strigachev, A.; Sumitomo, N.; Takalo, L. O.; Tamesue, Y.; Tanaka, K.; Thorstensen, J. R.; Tosti, G.; Trigilio, C.; Umana, G.; Vennes, S.; Vitek, S.; Volvach, A.; Webb, J.; Yamanaka, M.; Yim, H.-S.

    2007-12-01

    The quasar 3C 279 was the target of an extensive multiwavelength monitoring campaign from 2006 January through April. An optical-IR-radio monitoring campaign by the Whole Earth Blazar Telescope (WEBT) collaboration was organized around target-of-opportunity X-ray and soft γ-ray observations with Chandra and INTEGRAL in 2006 mid-January, with additional X-ray coverage by RXTE and Swift XRT. In this paper we focus on the results of the WEBT campaign. The source exhibited substantial variability of optical flux and spectral shape, with a characteristic timescale of a few days. The variability patterns throughout the optical BVRI bands were very closely correlated with each other, while there was no obvious correlation between the optical and radio variability. After the ToO trigger, the optical flux underwent a remarkably clean quasi-exponential decay by about 1 mag, with a decay timescale of τd~12.8 days. In intriguing contrast to other (in particular, BL Lac type) blazars, we find a lag of shorter wavelength behind longer wavelength variability throughout the RVB wavelength ranges, with a time delay increasing with increasing frequency. Spectral hardening during flares appears delayed with respect to a rising optical flux. This, in combination with the very steep IR-optical continuum spectral index of α0~1.5-2.0, may indicate a highly oblique magnetic field configuration near the base of the jet, leading to inefficient particle acceleration and a very steep electron injection spectrum. An alternative explanation through a slow (timescale of several days) acceleration mechanism would require an unusually low magnetic field of B<~0.2 G, about an order of magnitude lower than inferred from previous analyses of simultaneous SEDs of 3C 279 and other flat-spectrum radio quasars with similar properties. For questions regarding the availability of the data from the WEBT campaign presented in this paper, please contact the WEBT President Massimo Villata at villata@oato.inaf.it.

  15. Final Report: Stability of U (VII) and Tc (VII) Reducing Microbial Communities To Environmental Perturbation

    Energy Technology Data Exchange (ETDEWEB)

    Istok, Jonathan D

    2008-07-07

    'Bioimmobilization' of redox-sensitive metals and radionuclides is being investigated as a way to remediate contaminated groundwater and sediments. In this approach, growth-limiting substrates are added to stimulate the activity of targeted groups of indigenous microorganisms and create conditions favorable for the microbially-mediated precipitation ('bioimmobilization') of targeted contaminants. This project investigated a fundamentally new approach for modeling this process that couples thermodynamic descriptions for microbial growth with associated geochemical reactions. In this approach, a synthetic microbial community is defined as a collection of defined microbial groups; each with a growth equation derived from bioenergetic principles. The growth equations and standard-state free energy yields are appended to a thermodynamic database for geochemical reactions and the combined equations are solved simultaneously to predict the effect of added substrates on microbial biomass, community composition, and system geochemistry. This approach, with a single set of thermodynamic parameters (one for each growth equation), was used to predict the results of laboratory and field bioimmobilization experiments at two geochemically diverse research sites. Predicted effects of ethanol or acetate addition on uranium and technetium solubility, major ion geochemistry, mineralogy, microbial biomass and community composition were in general agreement with experimental observations although the available experimental data precluded rigorous model testing. Model simulations provide insight into the long-standing difficulty in transferring experimental results from the laboratory to the field and from one field site to the next, especially if the form, concentration, or delivery of growth substrate is varied from one experiment to the next. Although originally developed for use in better understanding bioimmobilization of uranium and technetium via reductive

  16. 99Tc(VII) Retardation, Reduction, and Redox Rate Scaling in Naturally Reduced Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yuanyuan; Liu, Chongxuan; Kukkadapu, Ravi K.; McKinley, James P.; Zachara, John M.; Plymale, Andrew E.; Miller, Micah D.; Varga, Tamas; Resch, Charles T.

    2015-10-15

    Abstract: An experimental and modeling study was conducted to investigate pertechnetate (Tc(VII)) retardation, reduction, and rate scaling in three sediments from Ringold formation at U.S. Department of Energy’s Hanford site, where 99Tc is a major contaminant in groundwater. Tc(VII) was reduced in all the sediments in both batch reactors and diffusion columns, with a faster rate in a sediment containing a higher concentration of HCl-extractable Fe(II). Tc(VII) migration in the diffusion columns was reductively retarded with retardation degrees correlated with Tc(VII) reduction rates. The reduction rates were faster in the diffusion columns than those in the batch reactors, apparently influenced by the spatial distribution of redox-reactive minerals along transport paths that supplied Tc(VII). X-ray computed tomography and autoradiography were performed to identify the spatial locations of Tc(VII) reduction and transport paths in the sediments, and results generally confirmed the newly found behavior of reaction rate changes from batch to column. The results from this study implied that Tc(VII) migration can be reductively retarded at Hanford site with a retardation degree dependent on reactive Fe(II) content and its distribution in sediments. This study also demonstrated that an effective reaction rate may be faster in transport systems than that in well-mixed reactors.

  17. Tissue Factor–Factor VII Complex as a Key Regulator of Ovarian Cancer Phenotypes

    Directory of Open Access Journals (Sweden)

    Shiro Koizume

    2015-01-01

    Full Text Available Tissue factor (TF is an integral membrane protein widely expressed in normal human cells. Blood coagulation factor VII (fVII is a key enzyme in the extrinsic coagulation cascade that is predominantly secreted by hepatocytes and released into the bloodstream. The TF–fVII complex is aberrantly expressed on the surface of cancer cells, including ovarian cancer cells. This procoagulant complex can initiate intracellular signaling mechanisms, resulting in malignant phenotypes. Cancer tissues are chronically exposed to hypoxia. TF and fVII can be induced in response to hypoxia in ovarian cancer cells at the gene expression level, leading to the autonomous production of the TF–fVII complex. Here, we discuss the roles of the TF–fVII complex in the induction of malignant phenotypes in ovarian cancer cells. The hypoxic nature of ovarian cancer tissues and the roles of TF expression in endometriosis are discussed. Arguments will be extended to potential strategies to treat ovarian cancers based on our current knowledge of TF–fVII function.

  18. The Effect of Neonatal Gene Therapy on Skeletal Manifestations in Mucopolysaccharidosis VII Dogs after a Decade

    Science.gov (United States)

    Xing, Elizabeth M.; Knox, Van W.; O'Donnell, Patricia A.; Sikura, Tracey; Liu, Yuli; Wu, Susan; Casal, Margret L.; Haskins, Mark E.; Ponder, Katherine P.

    2013-01-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disease due to deficient activity of β-glucuronidase (GUSB), and results in glycosaminoglycan accumulation. Skeletal manifestations include bone dysplasia, degenerative joint disease, and growth retardation. One gene therapy approach for MPS VII involves neonatal intravenous injection of a gamma retroviral vector expressing GUSB, which results in stable expression in liver and secretion of enzyme into blood at levels predicted to be similar or higher to enzyme replacement therapy. The goal of this study was to evaluate the long-term effect of neonatal gene therapy on skeletal manifestations in MPS VII dogs. Treated MPS VII dogs could walk throughout their lives, while untreated MPS VII dogs could not stand beyond 6 months and were dead by 2 years. Luxation of the coxofemoral joint and the patella, dysplasia of the acetabulum and supracondylar ridge, deep erosions of the distal femur, and synovial hyperplasia were reduced, and the quality of articular bone was improved in treated dogs at 6 to 11 years of age compared with untreated MPS VII dogs at 2 years or less. However, treated dogs continued to have osteophyte formation, cartilage abnormalities, and an abnormal gait. Enzyme activity was found near synovial blood vessels, and there was 2% as much GUSB activity in synovial fluid as in serum. We conclude that neonatal gene therapy reduces skeletal abnormalities in MPS VII dogs, but clinically-relevant abnormalities remain. Enzyme replacement therapy will probably have similar limitations long-term. PMID:23628461

  19. On the Direct Correlation between Gamma-Rays and PeV Neutrinos from Blazars

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Shan; Pohl, Martin; Winter, Walter, E-mail: shan.gao@desy.de [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, D-15738 Zeuthen (Germany)

    2017-07-10

    We study the frequently used assumption in multi-messenger astrophysics that the gamma-ray and neutrino fluxes are directly connected because they are assumed to be produced by the same photohadronic production chain. An interesting candidate source for this test is the flat-spectrum radio quasar PKS B1424-418, which recently called attention to a potential correlation between an IceCube PeV neutrino event and its burst phase. We simulate both the multi-waveband photon and the neutrino emission from this source using a self-consistent radiation model. We demonstrate that a simple hadronic model cannot adequately describe the spectral energy distribution for this source, but a lepto-hadronic model with a subdominant hadronic component can reproduce the multi-waveband photon spectrum observed during various activity phases of the blazar. As a conclusion, up to about 0.3 neutrino events may coincide with the burst, which implies that the leptonic contribution dominates in the relevant energy band. We also demonstrate that the time-wise correlation between the neutrino event and burst phase is weak.

  20. Bulk Comptonization: new hints from the luminous blazar 4C+25.05

    Science.gov (United States)

    Kammoun, E. S.; Nardini, E.; Risaliti, G.; Ghisellini, G.; Behar, E.; Celotti, A.

    2018-01-01

    Blazars are often characterized by a spectral break at soft X-rays, whose origin is still debated. While most sources show a flattening, some exhibit a blackbody-like soft excess with temperatures of the order of ∼0.1 keV, similar to low-luminosity, non-jetted Seyferts. Here, we present the analysis of the simultaneous XMM-Newton and NuSTAR observations of the luminous flat-spectrum radio quasar 4C+25.05 (z = 2.368). The observed 0.3-30 keV spectrum is best described by the sum of a hard X-ray power law (Γ = 1.38_{-0.03}^{+0.05}) and a soft component, approximated by a blackbody with kT_BB = 0.66_{-0.04}^{+0.05} keV (rest frame). If the spectrum of 4C+25.05 is interpreted in the context of bulk Comptonization by cold electrons of broad-line region photons emitted in the direction of the jet, such an unusual temperature implies a bulk Lorentz factor of the jet of Γbulk ∼ 11.7. Bulk Comptonization is expected to be ubiquitous on physical grounds, yet no clear signature of it has been found so far, possibly due to its transient nature and the lack of high-quality, broad-band X-ray spectra.

  1. A New Statistical Approach to the Optical Spectral Variability in Blazars

    Directory of Open Access Journals (Sweden)

    Jose A. Acosta-Pulido

    2016-12-01

    Full Text Available We present a spectral variability study of a sample of about 25 bright blazars, based on optical spectroscopy. Observations cover the period from the end of 2008 to mid 2015, with an approximately monthly cadence. Emission lines have been identified and measured in the spectra, which permits us to classify the sources into BL Lac-type or FSRQs, according to the commonly used EW limit. We have obtained synthetic photometry and produced colour-magnitude diagrams which show different trends associated with the object classes: generally, BL Lacs tend to become bluer when brighter and FSRQs become redder when brighter, although several objects exhibit both trends, depending on brightness. We have also applied a pattern recognition algorithm to obtain the minimum number of physical components which can explain the variability of the optical spectrum. We have used NMF (Non-Negative Matrix Factorization instead of PCA (Principal Component Analysis to avoid un-realistic negative components. For most targets we found that 2 or 3 meta-components are enough to explain the observed spectral variability.

  2. VizieR Online Data Catalog: Five years of blazar observations with VERITAS (Archambault+, 2016)

    Science.gov (United States)

    Archambault, S.; Archer, A.; Benbow, W.; Bird, R.; Biteau, J.; Buchovecky, M.; Buckley, J. H.; Bugaev, V.; Byrum, K.; Cerruti, M.; Chen, X.; Ciupik, L.; Connolly, M. P.; Cui, W.; Eisch, J. D.; Errando, M.; Falcone, A.; Feng, Q.; Finley, J. P.; Fleischhack, H.; Fortin, P.; Fortson, L.; Furniss, A.; Gillanders, G. H.; Griffin, S.; Grube, J.; Gyuk, G.; Hutten, M.; Hakansson, N.; Hanna, D.; Holder, J.; Humensky, T. B.; Johnson, C. A.; Kaaret, P.; Kar, P.; Kelley-Hoskins, N.; Kertzman, M.; Kieda, D.; Krause, M.; Krennrich, F.; Kumar, S.; Lang, M. J.; Maier, G.; McArthur, S.; McCann, A.; Meagher, K.; Moriarty, P.; Mukherjee, R.; Nguyen, T.; Nieto, D.; O'Faolain de Bhroithe, A.; Ong, R. A.; Otte, A. N.; Park, N.; Perkins, J. S.; Pichel, A.; Pohl, M.; Popkow, A.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Richards, G. T.; Roache, E.; Rovero, A. C.; Santander, M.; Sembroski, G. H.; Shahinyan, K.; Smith, A. W.; Staszak, D.; Telezhinsky, I.; Tucci, J. V.; Tyler, J.; Vincent, S.; Wakely, S. P.; Weiner, O. M.; Weinstein, A.; Williams, D. A.; Zitzer, B.

    2018-04-01

    In this paper, we present the results of the analysis of most of the non-detected blazars observed by VERITAS from 2007 (the beginning of full-scale scientific operations) to 2012 August (before the upgrade of the VERITAS array, see Kieda 2013arXiv1308.4849D). The VERITAS (Very Energetic Radiation Imaging Telescope Array System) telescope array is composed of four IACTs of 12 m diameter each, located at the Fred Lawrence Whipple Observatory, on the slopes of Mount Hopkins, in southern Arizona (31°40'N, 110°57'W). Each telescope has a segmented mirror that focuses light onto a camera composed of 499 photomultipliers located at the focal plane. The instrument FOV is 3.5°. For further details on the VERITAS instrument, see Holder et al. (2006APh....25..391H) and Holder (2011ICRC...12..137H). The VERITAS observations here have an average length of 20 minutes (referred to as a run), before switching targets or wobble directions. (7 data files).

  3. The TeV blazar measurement of the extragalactic background light

    Energy Technology Data Exchange (ETDEWEB)

    Reesman, Rebecca; Walker, T.P., E-mail: rreesman@physics.osu.edu, E-mail: twalker@mps.ohio-state.edu [Department of Physics, The Ohio State University, Columbus, OH, 43210 (United States)

    2013-12-01

    Gamma-rays propagating through space are likely to be extinguished via electron-positron pair production off of the ambient extragalactic background light (EBL). The spectrum of the EBL is produced by starlight (and starlight reprocessed by dust) from all galaxies throughout the history of the Universe. The attenuation of 40–400 GeV gamma-rays has been observed by Fermi and used to measure the EBL spectrum over energies 1 eV–10 eV out to redshift z ∼ 1. Measurements of several TeV blazers are consistent with attenuation, attributed to the EBL at redshift z ∼ 0.1. Here we simultaneously analyze a set of TeV blazers at z ∼ 0.1 to measure the optical depth for 100 GeV–10 TeV gamma-rays, which interact with EBL of energies 0.05 eV–5 eV. Using a suite of models for the EBL, we show that the optical depth indicated by TeV blazar attenuation is in good agreement with the optical depths measured by Fermi at lower gamma-ray energies and higher redshifts.

  4. Characteristics of Gamma-Ray Loud Blazars in the VLBA Imaging and Polarimetry Survey

    Science.gov (United States)

    Linford, J. D.; Taylor, G. B.; Romani, R. W.; Healey, S. E.; Helmboldt, J. F.; Readhead, A. C.; Reeves, R.; Richards, J. L.; Cotter, G.

    2010-01-01

    The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed as part of the VLBA Imaging and Polarimetry Survey. This large, flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong gamma-ray emission. At lower flux levels, radio flux density does not directly correlate with gamma-ray flux. We find that the LAT-detected BL Lac objects tend to be similar to the non-LAT BL Lac objects, but that the LAT-detected FSRQs are often significantly different from the non-LAT FSRQs. The differences between the gamma-ray loud and quiet FSRQS can be explained by Doppler boosting; these objects appear to require larger Doppler factors than those of the BL Lac objects. It is possible that the gamma-ray loud FSRQs are fundamentally different from the gamma-ray quiet FSRQs. Strong polarization at the base of the jet appears to be a signature for gamma-ray loud AGNs.

  5. Discovery of a Highly Polarized Optical Microflare in Blazar S5 0716+714 during the 2014 WEBT Campaign

    Science.gov (United States)

    Bhatta, G.; Goyal, A.; Ostrowski, M.; Stawarz, Ł.; Akitaya, H.; Arkharov, A. A.; Bachev, R.; Benítez, E.; Borman, G. A.; Carosati, D.; Cason, A. D.; Damljanovic, G.; Dhalla, S.; Frasca, A.; Hu, S.-M.; Itoh, R.; Jorstad, S.; Jableka, D.; Kawabata, K. S.; Klimanov, S. A.; Kurtanidze, O.; Larionov, V. M.; Laurence, D.; Leto, G.; Markowitz, A.; Marscher, A. P.; Moody, J. W.; Moritani, Y.; Ohlert, J. M.; Di Paola, A.; Raiteri, C. M.; Rizzi, N.; Sadun, A. C.; Sasada, M.; Sergeev, S.; Strigachev, A.; Takaki, K.; Troitsky, I. S.; Ui, T.; Villata, M.; Vince, O.; Webb, J. R.; Yoshida, M.; Zola, S.; Hiriart, D.

    2015-08-01

    The occurrence of low-amplitude flux variations in blazars on hourly timescales, commonly known as microvariability, is still a widely debated subject in high-energy astrophysics. Several competing scenarios have been proposed to explain such occurrences, including various jet plasma instabilities leading to the formation of shocks, magnetic reconnection sites, and turbulence. In this Letter, we present the results of our detailed investigation of a prominent, five-hour-long optical microflare detected during the recent WEBT campaign on 2014 March 2-6 targeting the blazar 0716+714. After separating the flaring component from the underlying base emission continuum of the blazar, we find that the microflare is highly polarized, with the polarization degree ˜(40-60)% ± (2-10)% and the electric vector position angle ˜(10-20)° ± (1-8)° slightly misaligned with respect to the position angle of the radio jet. The microflare evolution in the (Q,U) Stokes parameter space exhibits a looping behavior with a counterclockwise rotation, meaning the polarization degree decreases with the flux (but is higher in the flux decaying phase), and an approximately stable polarization angle. The overall very high polarization degree of the flare, its symmetric flux rise and decay profiles, and also its structured evolution in the Q-U plane all imply that the observed flux variation corresponds to a single emission region characterized by a highly ordered magnetic field. As discussed in the paper, a small-scale but strong shock propagating within the outflow, and compressing a disordered magnetic field component, provides a natural, though not unique, interpretation of our findings. The data collected by the WEBT Collaboration are stored in the WEBT archive; for questions regarding their availability, please contact the WEBT President Massimo Villata ().

  6. Optical Spectroscopic Observations of γ-Ray Blazar Candidates. III. The 2013/2014 Campaign in the Southern Hemisphere

    Science.gov (United States)

    Landoni, M.; Massaro, F.; Paggi, A.; D'Abrusco, R.; Milisavljevic, D.; Masetti, N.; Smith, H. A.; Tosti, G.; Chomiuk, L.; Strader, J.; Cheung, C. C.

    2015-05-01

    We report the results of our exploratory program carried out with the southern Astrophysical Research telescope aimed at associating counterparts and establishing the nature of the Fermi Unidentified γ-ray Sources (UGSs). We selected the optical counterparts of six UGSs from the Fermi catalog on the basis of our recently discovered tight connection between infrared and γ-ray emission found for the γ-ray blazars detected by the Wide-Field Infrared Survey Explorer in its all-sky survey. We perform for the first time a spectroscopic study of the low-energy counterparts of the Fermi UGSs, in the optical band, confirming the blazar-like nature of the whole sample. We also present new spectroscopic observations of six active galaxies of uncertain type associated with Fermi sources which appear to be BL Lac objects. Finally, we report the spectra collected for six known γ-ray blazars belonging to the Roma BZCAT that were obtained to establish their nature or better estimate their redshifts. Two interesting cases of high redshift and extremely luminous BL Lac objects (z ≥ 1.18 and z ≥ 1.02, based on the detection of Mg ii intervening systems) are also discussed. Based on observations obtained at the southern Astrophysical Research (SOAR) telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the U.S. National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

  7. Development of RP-HPLC, Stability Indicating Method for Degradation Products of Linagliptin in Presence of Metformin HCl by Applying 2 Level Factorial Design; and Identification of Impurity-VII, VIII and IX and Synthesis of Impurity-VII

    Directory of Open Access Journals (Sweden)

    Sushant B. Jadhav

    2017-06-01

    Full Text Available The novel reverse phase-high performance liquid chromatography (RP-HPLC, stability indicating method was developed for determination of linagliptin (LGP and its related substances in linagliptin and metformin HCl (MET HCl tablets by implementing design of experiment to understand the critical method parameters and their relation with critical method attributes; to ensure robustness of the method. The separation of nine specified impurities was achieved with a Zorbax SB-Aq 250 × 4.6 mm, 5 µm column, using gradient elution and a detector wavelength of 225 nm, and validated in accordance with International Conference on Harmonization (ICH guidelines and found to be accurate, precise, reproducible, robust, and specific. The drug was found to be degrading extensively in heat, humidity, basic, and oxidation conditions and was forming degradation products during stability studies. After slight modification in the buffer and the column, the same method was used for liquid chromatography–mass spectrometry (LC-MS and ultra-performance liquid chromatography -time-of-flight/mass spectrometry UPLC-TOF/MS analysis, to identify m/z and fragmentation of maximum unspecified degradation products i.e., Impurity-VII (7, Impurity-VIII (8, and Impurity-IX (9 formed during stability studies. Based on the results, a degradation pathway for the drug has been proposed and synthesis of Impurity-VII (7 is also discussed to ensure an in-depth understanding of LGP and its related degradation products and optimum performance during the lifetime of the product.

  8. The Financial Regulations of the Agency. Amendment of Articles V, VI and VII

    International Nuclear Information System (INIS)

    1960-01-01

    On 13 January 1960 the Board of Governors made certain changes in Articles V, VI and VII of the Financial Regulations. The Articles thus amended are reproduced in this document for the information of all Members of the Agency

  9. Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: Efficacy of vaccination

    Science.gov (United States)

    Here we describe the characterization a virulent genotype VII Newcastle disease virus (NDV) from Venezuela and evaluate the efficacy of heterologous genotype commercial vaccination under field and controlled rearing conditions. Biological pathotyping and molecular analysis were applied. Results sh...

  10. Viis raamatutäit poola näidendeid / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    Tõlkija Hendrik Lindepuult ilmus viies tõlkekogumik poola dramaturgia tippteoseid tutvustavast sarjast. Seekord said kaante vahele Tadeusz Rozewiczi näidendid "Valge abielu", "Lõks" ja "Vana naine haub"

  11. Vehicle infrastructure integration (VII) based road-condition warning system for highway collision prevention.

    Science.gov (United States)

    2009-05-01

    As a major ITS initiative, the Vehicle Infrastructure Integration (VII) program is to revolutionize : transportation by creating an enabling communication infrastructure that will open up a wide range of : safety applications. The road-condition warn...

  12. Addition to the analysis of the Sr VI and Sr VII spectra

    International Nuclear Information System (INIS)

    Wyart, J.F.

    1989-01-01

    Fifty-six lines of multicharged strontium are measured with an improved wavelength accuracy, or interpreted for the first time. They are 4p-4s, 4p-5s and 4p-4d transitions in Sr VII and 4p-5s transitions in Sr VI. The revision of the singlet-triplet connection in Sr VII is supported by theoretical survey of the ground configuration in Ge-like ions. (orig.)

  13. PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH DAN PENGEMBANGAN KARAKTER PADA SISWA KELAS VII MELALUI MODEL PBL BERBANTUAN SCAFFOLDING

    OpenAIRE

    Novy Kris Zaini; Wuryanto Wuryanto; Hery Sutarto

    2016-01-01

    Tujuan penelitian ini adalah untuk mengetahui (1) apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat mencapai KKM yang ditetapkan, (2) apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat meningkatkan kemampuan pemecahan masalah peserta didik pilihan, (3) apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pad...

  14. United Nations Charter, Chapter VII, Article 43: Now or Never.

    Science.gov (United States)

    Burkle, Frederick M

    2018-04-25

    For more than 75 years, the United Nations Charter has functioned without the benefit of Chapter VII, Article 43, which commits all United Nations member states "to make available to the Security Council, on its call, armed forces, assistance, facilities, including rights of passage necessary for the purpose of maintaining international peace and security." The consequences imposed by this 1945 decision have had a dramatic negative impact on the United Nation's functional capacity as a global body for peace and security. This article summarizes the struggle to implement Article 43 over the decades from the onset of the Cold War, through diplomatic attempts during the post-Cold War era, to current and often controversial attempts to provide some semblance of conflict containment through peace enforcement missions. The rapid growth of globalization and the capability of many nations to provide democratic protections to their populations are again threatened by superpower hegemony and the development of novel unconventional global threats. The survival of the United Nations requires many long overdue organizational structure and governance power reforms, including implementation of a robust United Nations Standing Task Force under Article 43. (Disaster Med Public Health Preparedness. 2018;page 1 of 8).

  15. Structural incorporation of MgCl2 into ice VII at room temperature

    Science.gov (United States)

    Watanabe, Mao; Komatsu, Kazuki; Noritake, Fumiya; Kagi, Hiroyuki

    2017-05-01

    Raman spectra and X-ray diffraction patterns were obtained from 1:100 and 1:200 \\text{MgCl}2:\\text{H}2\\text{O} solutions (in molar ratio) at pressures up to 6 GPa using diamond anvil cells (DACs) and compared with those of pure water. The O-H stretching band from ice VII crystallized from the 1:200 solution was approximately 10 cm-1 higher than that of pure ice VII. The phase boundaries between ice VII and VIII crystallized from the MgCl2 solutions at 4 GPa were 2 K lower than those of pure ice VII and VIII. These observations indicate that ice VII incorporates MgCl2 into its structure. The unit cell volumes of ice VII crystallized from pure water and the two solutions coincided with each other within the experimental error, and salt incorporation was not detectable from the cell volume. Possible configurations of ion substitution and excess volume of ice VIII were simulated on the basis of density functional theory (DFT) calculations.

  16. Widespread biochemical correction of murine mucopolysaccharidosis type VII pathology by liver hydrodynamic plasmid delivery.

    Science.gov (United States)

    Richard, M; Arfi, A; Seguin, J; Gandolphe, C; Scherman, D

    2009-06-01

    Mucopolysaccharidosis type VII (MPS VII) is a lysosomal storage disease caused by a deficiency of the acid hydrolase beta-glucuronidase. MPS VII mice develop progressive lysosomal accumulation of glycosaminoglycans (GAGs) within multiple organs, including the brain. Using this animal model, we compared two plasmid gene administration techniques: muscle electrotransfer and liver-directed transfer using hydrodynamic injection. We have evaluated both the expression kinetics and the biodistribution of beta-glucuronidase activity after gene transfer, as well as the correction of biochemical abnormalities in various organs. This study shows that MPS VII mice treated with a plasmid-bearing mouse beta-glucuronidase cDNA, acquire the ability to produce the beta-glucuronidase enzyme for an extended period of time. The liver seemed to be more appropriate than the muscle as a target organ to enable enzyme secretion into the systemic circulation. A beneficial effect on the MPS VII pathology was also observed, as liver-directed gene transfer led to the correction of secondary enzymatic elevations and to the reduction of GAGs storage in peripheral tissues and brain, as well as to histological correction in many tissues. This work is one of the first examples showing that non-viral plasmid DNA delivery can lead to improvements in both peripheral and brain manifestations of MPS VII disease. It confirms the potential of non-viral systemic gene transfer strategy in neurological lysosomal disorders.

  17. Search for neutrino emission in gamma-ray flaring blazars with the ANTARES telescope

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez Losa, Agustín, E-mail: agustin.sanchez@ific.uv.es [IFIC, Apartado de Correos 22085, E-46071 Valencia (Spain)

    2013-10-11

    The ANTARES telescope observes a full hemisphere of the sky all the time with a duty cycle close to 100%. This makes it well suited for an extensive observation of neutrinos produced in astrophysical transient sources. In the surrounding medium of blazars, i.e. active galactic nuclei with their jets pointing almost directly toward the observer, neutrinos may be produced together with gamma-rays by hadronic interactions, so a strong correlation between neutrinos and gamma-rays emissions is expected. The time variability information of the studied source can be obtained by the gamma-ray light curves measured by the LAT instrument on-board the Fermi satellite. If the expected neutrino flux observation is reduced to a narrow window around the assumed neutrino production period, the point-source sensitivity can be drastically improved. The ANTARES data collected in 2008 has been analyzed looking for neutrinos detected in the high state period of 10 bright and variable Fermi sources assuming that the neutrino emission follows the gamma-ray light curves. First results show a sensitivity improvement by a factor 2–3 with respect to a standard time-integrated point source search. The analysis has been done with an unbinned method based on the minimization of a likelihood ratio applied to data corresponding to a live time of 60 days. The width of the flaring periods ranges from 1 to 20 days. Despite the fact that the most significant studied source is compatible with background fluctuations, recently detected flares promise interesting future analyze.

  18. Science with the ASTRI mini-array for the Cherenkov Telescope Array: blazars and fundamental physics

    Science.gov (United States)

    Bonnoli, Giacomo; Tavecchio, Fabrizio; Giuliani, Andrea; Bigongiari, Ciro; Di Pierro, Federico; Stamerra, Antonio; Pareschi, Giovanni; Vercellone, Stefano; ASTRI Collaboration; CTA Consortium

    2016-05-01

    ASTRI (“Astronomia a Specchi con Tecnologia Replicante Italiana”) is a flagship project of the Italian Ministry of Research (MIUR), devoted to the realization, operation and scientific validation of an end-to-end prototype for the Small Size Telescope (SST) envisaged to become part of the Cherenkov Telescope Array (CTA). The ASTRI SST-2M telescope prototype is characterized by a dual mirror, Schwarzschild-Couder optical design and a compact camera based on silicon photo-multipliers. It will be sensitive to multi-TeV very high energy (VHE) gamma rays up to 100 TeV, with a PSF ~ 6’ and a wide (9.6°) unaberrated optical field of view. Right after validation of the design in single-dish observations at the Serra La Nave site (Sicily, Italy) during 2015, the ASTRI collaboration will be able to start deployment, at the final CTA southern site, of the ASTRI mini-array, proposed to constitute the very first CTA precursor. Counting 9 ASTRI SST-2M telescopes, the ASTRI mini-array will overtake current IACT systems in differential sensitivity above 5 TeV, thus allowing unprecedented observations of known and predicted bright TeV emitters in this band, including some extragalactic sources such as extreme high-peaked BL Lacs with hard spectra. We exploited the ASTRI scientific simulator ASTRIsim in order to understand the feasibility of observations tackling blazar and cosmic ray physics, including discrimination of hadronic and leptonic scenarios for the VHE emission from BL Lac relativistic jets and indirect measurements of the intergalactic magnetic field and of the extragalactic background light. We selected favorable targets, outlining observation modes, exposure times, multi-wavelength coverage needed and the results expected. Moreover, the perspectives for observation of effects due to the existence of axion-like particles or to Lorentz invariance violations have been investigated.

  19. Exploring the blazar zone in high-energy flares of FSRQs

    Energy Technology Data Exchange (ETDEWEB)

    Pacciani, L.; Donnarumma, I. [INAF-Istituto di Astrofisica e Planetologia Spaziale, Via Fosso del Cavaliere 100, I-00133 Rome (Italy); Tavecchio, F. [INAF-Osservatorio Astronomico di Brera, via E. Bianchi 46, I-23807 Merate (Italy); Stamerra, A. [INAF-Osservatorio Astrofisico di Torino, via P. Giuria 1, I-10125 Torino (Italy); Carrasco, L.; Recillas, E.; Porras, A. [Instituto Nacional de Astrofisica, Optica y Electronica, Mexico, Luis E, Erro 1, Sta. Maria Tonantzintla, Puebla, CP 72840 (Mexico); Uemura, M., E-mail: luigi.pacciani@iaps.inaf.it [Hiroshima Astrophysical Science Center, Hiroshima University 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526 (Japan)

    2014-07-20

    The gamma-ray emission offers a powerful diagnostic tool to probe jets and their surroundings in flat-spectrum radio quasars (FSRQs). In particular, sources emitting at high energies (>10 GeV) give us the strongest constraints. This motivates us to start a systematic study of flares with bright emission above 10 GeV, examining archival data of the Fermi-LAT gamma-ray telescope. At the same time, we began to trigger Target of Opportunity observations to the Swift observatory at the occurrence of high-energy flares, obtaining a wide coverage of the spectral energy distributions (SEDs) for several FSRQs during flares. Among others, we investigate the SED of a peculiar flare of 3C 454.3, showing a remarkably hard gamma-ray spectrum, quite different from the brightest flares of this source, and a bright flare of CTA 102. We modeled the SED in the framework of the one-zone leptonic model, using also archival optical spectroscopic data to derive the luminosity of the broad lines and thus estimate the disk luminosity, from which the structural parameters of the FSRQ nucleus can be inferred. The model allowed us to evaluate the magnetic field intensity in the blazar zone and to locate the emitting region of gamma-rays in the particular case in which gamma-ray spectra show neither absorption from the broad-line region (BLR) nor the Klein-Nishina curvature expected in leptonic models assuming the BLR as the source of seed photons for the External Compton scenario. For FSRQs bright above 10 GeV, we were able to identify short periods lasting less than one day characterized by a high rate of high-energy gamma-rays and hard gamma-ray spectra. We discussed the observed spectra and variability timescales in terms of injection and cooling of energetic particles, arguing that these flares could be triggered by magnetic reconnection events or turbulence in the flow.

  20. Variability of Blazars JH Fan1,2,∗ , Y. Liu1,2, Y. Li3, QF Zhang3, J ...

    Indian Academy of Sciences (India)

    5Joint Institute for Galaxies and Cosmology, ShAO and USTC, CAS, Shanghai 200030, China. 6Abastumani Observatory .... We have monitored dozens of blazars on 1.56 m telescope at Sheshan station, Shang- hai Astronomical Observatory. .... Poon, H., Fan, J. H., Fu, J. N. 2009, Astrophys. J. Suppl. Ser., 185, 511.

  1. VLT/X-Shooter spectrum of the blazar TXS 0506+056 (located inside the IceCube-170922A error box)

    Science.gov (United States)

    Coleiro, Alexis; Chaty, Sylvain

    2017-10-01

    The blazar TXS 0506+056 (PMN J0509+0541) is currently reported to show increased gamma-ray and optical activity (ATel #10791, #10792, #10794, #10799, #10801, #10817, #10830, #10831, #10838) and has been proposed as the counterpart to the high-energy neutrino event IceCube-170922A (https://gcn.gsfc.nasa.gov/notices_amon/50579430_130033.amon).

  2. Modelling blazar flaring using a time-dependent fluid jet emission model - an explanation for orphan flares and radio lags

    Science.gov (United States)

    Potter, William J.

    2018-01-01

    Blazar jets are renowned for their rapid violent variability and multiwavelength flares, however, the physical processes responsible for these flares are not well understood. In this paper, we develop a time-dependent inhomogeneous fluid jet emission model for blazars. We model optically thick radio flares for the first time and show that they are delayed with respect to the prompt optically thin emission by ∼months to decades, with a lag that increases with the jet power and observed wavelength. This lag is caused by a combination of the travel time of the flaring plasma to the optically thin radio emitting sections of the jet and the slow rise time of the radio flare. We predict two types of flares: symmetric flares - with the same rise and decay time, which occur for flares whose duration is shorter than both the radiative lifetime and the geometric path-length delay time-scale; extended flares - whose luminosity tracks the power of particle acceleration in the flare, which occur for flares with a duration longer than both the radiative lifetime and geometric delay. Our model naturally produces orphan X-ray and γ-ray flares. These are caused by flares that are only observable above the quiescent jet emission in a narrow band of frequencies. Our model is able to successfully fit to the observed multiwavelength flaring spectra and light curves of PKS1502+106 across all wavelengths, using a transient flaring front located within the broad-line region.

  3. Fast ion loss and radial electric field in Wendelstein VII-Λ stellarator

    International Nuclear Information System (INIS)

    Itoh, K.; Sanuki, H.; Itoh, S.

    1991-10-01

    Theoretical model is developed to determine the radial electric field and the fast ion loss simultaneously in stellarators, and is applied to the Wendelstein VII-A stellarator. The predicted value of the radial electric field is more closer to experiments than the purely neoclassical calculation. The loss rate, which is determined simultaneously, is in the range of experimental observations. The partition of the injection energy by the bulk heating, direct orbit loss and shine through is estimated by using the self consistent electric field profile. The orbit loss become noticeable as the injection energy increases. The influence of the neutral particles is also studied. Neutral particles enhances the negative radial electric field, and reduces the direct orbit loss by the expense of the charge exchange loss. The impact of the increased radial electric field on the neoclassical ion thermal energy loss is compared to the direct loss of fast ions. The reduction of the neoclassical loss is much smaller than the orbit loss. (author)

  4. Immobilization of 99-Technetium (VII) by Fe(II)-Goethite and Limited Reoxidation

    International Nuclear Information System (INIS)

    Um, Wooyong; Chang, Hyun-Shik; Icenhower, Jonathan P.; Lukens, Wayne W.; Serne, R. Jeffrey; Qafoku, Nikolla; Westsik, Joseph H.; Buck, Edgar C.; Smith, Steven C.

    2011-01-01

    Synthesized goethite was successfully used with addition of Fe(II) to sequester Tc present in both deionized water and simulated off-gas scrubber waste solutions. Pertechnetate concentration in solution decreased immediately when the pH was raised above 7 by addition of sodium hydroxide. Removal of Tc(VII) from solution occurred most likely as a result of heterogeneous surface-catalyzed reduction to Tc(IV) and subsequent co-precipitation onto the goethite. The final Tc-bearing solid was identified as goethite-dominated Fe(III)-(oxy)hydroxide based on XRD analysis, confirming the widespread observation of its characteristic acicular habit by TEM/SEM images. Analysis of the solid precipitate by XAFS showed that the dominant oxidation state of Tc was Tc(IV) and was in octahedral coordination with Tc-O, Fe-O, and Tc-Fe bond distances that are consistent with direct substitution of Tc for Fe in the goethite structure. In some experiments the final Tc-goethite product was subsequently armored with additional layers of freshly precipitated goethite. Successful incorporation of Tc(IV) within the goethite mineral lattice and subsequent goethite armoring can limit re-oxidation of Tc(IV) and its subsequent release from Tc-goethite waste forms, even when the final product is placed in oxidizing environments that typify shallow waste burial facilities.

  5. Holographic fermions at strong translational symmetry breaking: a Bianchi-VII case study

    Energy Technology Data Exchange (ETDEWEB)

    Bagrov, A. [Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ (Netherlands); Kaplis, N.; Krikun, A.; Schalm, K.; Zaanen, J. [Institute Lorentz ITP, Leiden University, PO Box 9506, Leiden 2300 RA (Netherlands)

    2016-11-09

    It is presently unknown how strong lattice potentials influence the fermion spectral function of the holographic strange metals predicted by the AdS/CFT correspondence. This embodies a crucial test for the application of holography to condensed matter experiments. We show that for one particular momentum direction this spectrum can be computed for arbitrary strength of the effective translational symmetry breaking potential of the so-called Bianchi-VII geometry employing ordinary differential equations. Deep in the strange metal regime we find rather small changes to the single-fermion response computed by the emergent quantum critical IR, even when the potential becomes relevant in the infra-red. However, in the regime where holographic quasi-particles occur, defining a Fermi surface in the continuum, they acquire a finite lifetime at any finite potential strength. At the transition from irrelevancy to relevancy of the Bianchi potential in the deep infra-red the quasi-particle remnants disappear completely and the fermion spectrum exhibits a purely relaxational behaviour.

  6. Adenovirus core protein VII down-regulates the DNA damage response on the host genome.

    Science.gov (United States)

    Avgousti, Daphne C; Della Fera, Ashley N; Otter, Clayton J; Herrmann, Christin; Pancholi, Neha J; Weitzman, Matthew D

    2017-08-09

    Viral manipulation of cellular proteins allows viruses to suppress host defenses and generate infectious progeny. Due to the linear double-stranded DNA nature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a barrier for successful infection. The adenovirus genome is packaged with protein VII, a viral-encoded histone-like core protein that is suggested to protect incoming viral genomes from detection by cellular DNA damage machinery. We showed that protein VII localizes to host chromatin during infection, leading us to hypothesize that protein VII may affect DNA damage responses on the cellular genome. Here, we show that protein VII at cellular chromatin results in a significant decrease in accumulation of phosphorylated H2AX (γH2AX) following irradiation, indicating that protein VII inhibits DDR signaling. The oncoprotein SET was recently suggested to modulate the DDR by affecting access of repair proteins to chromatin. Since protein VII binds SET, we investigated a role for SET in DDR inhibition by protein VII. We show that knockdown of SET partially rescues the protein VII-induced decrease in γH2AX accumulation on the host genome, suggesting that SET is required for inhibition. Finally, we show that knockdown of SET also allows ATM to localize to incoming viral genomes bound by protein VII during infection with a mutant lacking early region E4. Together, our data suggest that the protein VII-SET interaction contributes to DDR evasion by adenovirus. Our results provide an additional example of a strategy used by adenovirus to manipulate the host DDR and show how viruses can modify cellular processes through manipulation of host chromatin. IMPORTANCE The DNA damage response (DDR) is a cellular network crucial for maintaining genome integrity. DNA viruses replicating in the nucleus challenge the resident genome and must overcome cellular responses, including the DDR. Adenoviruses are prevalent human pathogens that can cause a

  7. Dietary changes in fasting levels of factor VII coagulant activity (FVII:C) are accompanied by changes in factor VII protein and other vitamin K-dependent proteins

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Tholstrup, T; Marckmann, P

    1995-01-01

    The mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII:C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks...

  8. Topical application of recombinant activated factor VII during cesarean delivery for placenta previa.

    Science.gov (United States)

    Schjoldager, Birgit T B G; Mikkelsen, Emmeli; Lykke, Malene R; Præst, Jørgen; Hvas, Anne-Mette; Heslet, Lars; Secher, Niels J; Salvig, Jannie D; Uldbjerg, Niels

    2017-06-01

    During cesarean delivery in patients with placenta previa, hemorrhaging after removal of the placenta is often challenging. In this condition, the extraordinarily high concentration of tissue factor at the placenta site may constitute a principle of treatment as it activates coagulation very effectively. The presumption, however, is that tissue factor is bound to activated factor VII. We hypothesized that topical application of recombinant activated factor VII at the placenta site reduces bleeding without affecting intravascular coagulation. We included 5 cases with planned cesarean delivery for placenta previa. After removal of the placenta, the surgeon applied a swab soaked in recombinant activated factor VII containing saline (1 mg in 246 mL) to the placenta site for 2 minutes; this treatment was repeated once if the bleeding did not decrease sufficiently. We documented the treatment on video recordings and measured blood loss. Furthermore, we determined hemoglobin concentration, platelet count, international normalized ratio, activated partial thrombin time, fibrinogen (functional), factor VII:clot, and thrombin generation in peripheral blood prior to and 15 minutes after removal of the placenta. We also tested these blood coagulation variables in 5 women with cesarean delivery planned for other reasons. Mann-Whitney test was used for unpaired data. In all 5 cases, the uterotomy was closed under practically dry conditions and the median blood loss was 490 (range 300-800) mL. There were no adverse effects of recombinant activated factor VII and we did not measure factor VII to enter the circulation. Neither did we observe changes in thrombin generation, fibrinogen, activated partial thrombin time, international normalized ratio, and platelet count in the peripheral circulation (all P values >.20). This study indicates that in patients with placenta previa, topical recombinant activated factor VII may diminish bleeding from the placenta site without initiation

  9. Strategi Peningkatan Kualitas Pelayanan Jasa Transportasi Kereta Api (Studi Pada PT. Kereta Api Indonesia (Persero) Dearah Operasi VII Madiun)

    OpenAIRE

    Tri Juliyanto, Ilham

    2015-01-01

    : Quality Improvement Strategy Railway Transportation Services (Studi pada PT. Kereta Api Indonesia (Persero) Daerah Operasi VII Madiun). This research intended to discover the strategic which applied by PT. KAI DAOP VII Madiun for increasing the quality of service in train transportation, supporting factor and inhibiting factor strategic in increase of quality of service of PT. KAI DAOP VII Madiun. In this research, uses descriptive research with qualitative approach and use analysis method ...

  10. Verification and validation of ACE-format library created from ENDF/B-VII.0

    International Nuclear Information System (INIS)

    Chen Chaobin; Hu Zehua; Zhang Benai; Chen Yixue; Wu Jun

    2009-01-01

    ENDF/B-VII.0, released by the USA Cross Section Evaluation Working Group(CSEWG) in December 2006, was developed in five years since the previous release of ENDF/B-VI.8 and was demonstrated to contain much better physical representations of the data and to perform much better than previus ENDF evaluations over a broad range of applications. We generated ACE-format pointwise cross section library from the ENDF/B-VII.0 neutron reaction sublibrary with the processing code NJOY. The paper provides an overview of ENDF/B-VII.0, a summary of the ACE-format files producing process and a detail description of the validation of the ACE-format library. The conclusion is that the ACE-format library produced is correct. (authors)

  11. PEMAHAMAN OPERASI BILANGAN BULAT SISWA KELAS VII MELALUI PEMBELAJARAN KOOPERATIF TIPE NHT BERBANTUAN KARTU PAPAN BERMAGNET

    Directory of Open Access Journals (Sweden)

    Eka Mery Fatmawati Sukarno

    2017-05-01

    Full Text Available This research is aimed to describe the understanding of integer operations on students grade 7th by using cooperative learning type NHT assisted by magnetic board card. This is classroom action research (CAR and the participants are 21 students at class 7-A. Collected data are test, observation, and interview. The result of this research shows the increased understanding of integer operations on students grade 7th by using cooperative learning type NHT assisted by magnetic board card. Penelitian ini bertujuan untuk mendeskripsikan pemahaman operasi bilangan bulat siswa kelas VII melalui pembelajaran kooperatif tipe NHT berbantuan kartu papan bermagnet. Jenis penelitian yang digunakan adalah penelitian tindakan kelas (PTK dengan partisipan siswa-siswi kelas VII-A yang berjumlah 21 orang. Data yang dikumpulkan adalah tes, observasi, dan wawancara. Hasil penelitian menunjukkan adanya peningkatan pemahaman operasi bilangan bulat siswa kelas VII melalui pembelajaran kooperatif tipe NHT berbantuan kartu papan bermagnet.

  12. MULTIWAVELENGTH EVIDENCE FOR QUASI-PERIODIC MODULATION IN THE GAMMA-RAY BLAZAR PG 1553+113

    International Nuclear Information System (INIS)

    Ackermann, M.; Buehler, R.; Ajello, M.; Albert, A.; Baldini, L.; Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A.; Atwood, W. B.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Buson, S.; Becerra Gonzalez, J.; Bellazzini, R.; Bissaldi, E.; Bonino, R.; Bregeon, J.; Bruel, P.

    2015-01-01

    We report for the first time a γ-ray and multiwavelength nearly periodic oscillation in an active galactic nucleus. Using the Fermi Large Area Telescope we have discovered an apparent quasi-periodicity in the γ-ray flux (E > 100 MeV) from the GeV/TeV BL Lac object PG 1553+113. The marginal significance of the 2.18 ± 0.08 year period γ-ray cycle is strengthened by correlated oscillations observed in radio and optical fluxes, through data collected in the Owens Valley Radio Observatory, Tuorla, Katzman Automatic Imaging Telescope, and Catalina Sky Survey monitoring programs and Swift-UVOT. The optical cycle appearing in ∼10 years of data has a similar period, while the 15 GHz oscillation is less regular than seen in the other bands. Further long-term multiwavelength monitoring of this blazar may discriminate among the possible explanations for this quasi-periodicity

  13. A Search for QPOs in the Blazar OJ287: Preliminary Results from the 2015/2016 Observing Campaign

    Directory of Open Access Journals (Sweden)

    S. Zola

    2016-10-01

    Full Text Available We analyse the light curve in the R band of the blazar OJ287, gathered during the 2015/2016 observing season. We did a search for quasi-periodic oscillations (QPOs using several methods over a wide range of timescales. No statistically significant periods were found in the high-frequency domain both in the ground-based data and in Kepler observations. In the longer-period domain, the Lomb–Scargle periodogram revealed several peaks above the 99% significance level. The longest one—about 95 days—corresponds to the innermost stable circular orbit (ISCO period of the more massive black hole. The 43-day period could be an alias, or it can be attributed to accretion in the form of a two-armed spiral wave.

  14. Revisiting Quasi-periodic Modulation in γ -Ray Blazar PKS 2155-304 with Fermi Pass 8 Data

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Peng-fei; Liao, Neng-hui [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Yan, Da-hai; Wang, Jian-cheng, E-mail: zhangpengfee@pmo.ac.cn, E-mail: yandahai@ynao.ac.cn [Yunnan Observatory, Chinese Academy of Sciences, Kunming 650011 (China)

    2017-02-01

    We examine the gamma-ray quasi-periodic variability of PKS 2155-304 with the latest publicly available Fermi -LAT Pass 8 data, which covers the years from 2008 August to 2016 October. We produce the light curves in two ways: the exposure-weighted aperture photometry and the maximum likelihood optimization. The light curves are then analyzed by using Lomb-Scargle Periodogram (LSP) and Weighted Wavelet Z-transform, and the results reveal a significant quasi-periodicity with a period of 1.74±0.13 years and a significance of ∼4.9 σ . The constraint of multifrequencies quasi-periodic variabilities on blazar emission model is discussed.

  15. MULTIWAVELENGTH EVIDENCE FOR QUASI-PERIODIC MODULATION IN THE GAMMA-RAY BLAZAR PG 1553+113

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Department of Physics and Astronomy, Clemson University, Kinard Lab of Physics, Clemson, SC 29634-0978 (United States); Albert, A.; Baldini, L.; Blandford, R. D.; Bloom, E. D.; Bottacini, E.; Caliandro, G. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Atwood, W. B. [Santa Cruz Institute for Particle Physics, Department of Physics and Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Ballet, J. [Laboratoire AIM, CEA-IRFU/CNRS/Université Paris Diderot, Service d’Astrophysique, CEA Saclay, F-91191 Gif sur Yvette (France); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Becerra Gonzalez, J. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Bissaldi, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, I-70126 Bari (Italy); Bonino, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Torino, I-10125 Torino (Italy); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier, CNRS/IN2P3, Montpellier (France); Bruel, P., E-mail: David.J.Thompson@nasa.gov, E-mail: sara.cutini@asdc.asi.it, E-mail: stefano.ciprini@asdc.asi.it, E-mail: stefan@astro.su.se, E-mail: stamerra@oato.inaf.it [Laboratoire Leprince-Ringuet, École polytechnique, CNRS/IN2P3, Palaiseau (France); and others

    2015-11-10

    We report for the first time a γ-ray and multiwavelength nearly periodic oscillation in an active galactic nucleus. Using the Fermi Large Area Telescope we have discovered an apparent quasi-periodicity in the γ-ray flux (E > 100 MeV) from the GeV/TeV BL Lac object PG 1553+113. The marginal significance of the 2.18 ± 0.08 year period γ-ray cycle is strengthened by correlated oscillations observed in radio and optical fluxes, through data collected in the Owens Valley Radio Observatory, Tuorla, Katzman Automatic Imaging Telescope, and Catalina Sky Survey monitoring programs and Swift-UVOT. The optical cycle appearing in ∼10 years of data has a similar period, while the 15 GHz oscillation is less regular than seen in the other bands. Further long-term multiwavelength monitoring of this blazar may discriminate among the possible explanations for this quasi-periodicity.

  16. A hydrodynamical model for the Fermi-LAT γ-ray light curve of blazar PKS 1510-089

    Directory of Open Access Journals (Sweden)

    Cabrera J.I.

    2013-12-01

    Full Text Available A physical description of the formation and propagation of working surfaces inside the relativistic jet of the blazar PKS 1510-089 are used to model its γ -ray variability light curve using Fermi-LAT data from 2008 to 2012. The physical model is based on conservation laws of mass and momentum at the working surface as explained by Mendoza et al. (2009. The hydrodynamical description of a working surface is parametrized by the initial velocity and mass injection rate at the base of the jet. We show that periodic variations on the injected velocity profiles are able to account for the observed luminosity, fixing model parameters such as mass ejection rates of the central engine injected at the base of the jet, oscillation frequencies of the flow and maximum Lorentz factors of the bulk flow during a particular burst.

  17. A novel citrus viroid found in Australia, tentatively named citrus viroid VII.

    Science.gov (United States)

    Chambers, G A; Donovan, N J; Bodaghi, S; Jelinek, S M; Vidalakis, G

    2018-01-01

    A novel citrus viroid was discovered in a non-symptomatic Lisbon lemon (Citrus x limon L. Burm.f.) tree in New South Wales, Australia. Bioindexing, molecular detection and characterization involving sequencing combined with in silico analysis for the identification of the viroid-RNA hallmark properties of transmissibility and autonomous replication as well as specific sequence and structural motifs suggest that this viroid is a member of a new species in the genus Apscaviroid, family Pospiviroidae, which we have tentatively named "citrus viroid VII" (CVd-VII).

  18. VII International scientific conference Radiation-thermal effects and processes in inorganic materials. Proceedings

    International Nuclear Information System (INIS)

    2010-01-01

    In the collection there are the reports of the VII International scientific conference and the VII All-Russian school-conference Radiation-thermal effects and processes in inorganic materials which were conducted on October 2-10, 2010, in Tomsk. The reports deal with new developments of charged particles high-intensity beam sources, high-temperature metrology of high-current beams and work materials, radiation-thermal stimulated effects and processes in inorganic materials, physical basics of technological processes, radiation-thermal technologies and equipment for their realization, allied branches of science and technology, specifically, nanotechnologies [ru

  19. Newcastle disease outbreaks in recent years in Western Europe were caused by an old (VI) and a novel genotype (VII)

    DEFF Research Database (Denmark)

    Lomniczi, B.; Wehmann, E.; Herczeg, J.

    1998-01-01

    and Greece in the late 1960's and in Hungary in the early 1980's. In contrast, viruses that caused epizootics in Germany, Belgium, The Netherlands, Spain and Italy could be classified into a novel genotype (provisionally termed VII), hitherto undetected in Europe. It is possible that the genotype VII viruses...

  20. Dietary effects on coagulation factor VII vary across genotypes of the R/Q353 polymorphism in elderly people

    NARCIS (Netherlands)

    Mennen, L.I.; Maat, M.P.M. de; Schouten, E.G.; Kluft, C.; Witteman, J.C.M.; Hofman, A.; Grobbee, D.E.

    1998-01-01

    The objective of this study was to evaluate the association of factor VII with dietary factors while also considering the R/Q353 polymorphism. Nutrition is an important determinant of coagulation factor VII, which is also genetically determined by the R/Q353 polymorphism. High levels of coagulation

  1. 29 CFR 1425.3 - Functions of the Service under title VII of the Civil Service Reform Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Functions of the Service under title VII of the Civil Service Reform Act. 1425.3 Section 1425.3 Labor Regulations Relating to Labor (Continued) FEDERAL... Service under title VII of the Civil Service Reform Act. (a) The service may provide its assistance in any...

  2. Electron cyclotron resonance heating on the W VII A-stellarator

    International Nuclear Information System (INIS)

    Wilhelm, R.; Erckmann, V.; Janzen, G.

    1985-01-01

    Plasma build-up and heating of OH-current free plasmas by ECR-wave irradiation were investigated on the WENDELSTEIN VII-A stellarator using three kinds of wave launching: direct irradiation of the gyrotron modes from the low field side, or advanced wave launching in 0-mode polarization from the low field side, the nonabsorbed fraction being reflected back to the plasma from the high field side in X-mode polarization. An increase of the central electron temperature from 0.7 keV (TE 02 mode) to 1.2 keV (TE 11 , HE 11 mode) was observed which is explained by the narrow and well centred power deposition profiles for TE 11 , HE 11 modes. However, there is only a slight increase of the heating efficiency from 40% to 50%. The reflected X-mode fraction does not contribute to bulk plasma heating via Bernstein wave conversion and absorption as expected. The reason seems to be local absorption of the arising electron Bernstein waves due to a macroscopically turbulent structure around the upper hybrid resonance layer. Correlated with X-mode irradiation direct ion heating was observed (500 eV ion tail), possibly due to low frequency decay waves. In all ECRH experiments a toroidal plasma current was generated due to asymmetrically confined fast electrons. Optimum confinement in the shearless l=2 configuration was achieved at most irrational values of the rotational transform with small toroidal net current. It can be concluded from a numerical 1D-transport analysis that neoclassical electron confinement seems to be dominant in the hot central plasma core

  3. In Like a Lamb, Out Like a Lion: Probing the Disk-Jet Connection in Fermi Gamma-ray Bright Blazars

    Science.gov (United States)

    Isler, Jedidah C.

    Blazars are active galactic nuclei whose relativistic jet is aligned at small angles (detected, making them an ideal laboratory to study the energetics of infalling and outflowing material. The simultaneously obtained multiwavelength, long-term data analyzed here help to better evaluate the impact of jet power on the broadband spectral energy distributions of these sources via the OIR color variability analysis. Secondly, emission line variability studies presented here can help constrain the location of the gamma-emitting region as well set preliminary constraints on the minimum jet contribution necessary to significantly increase the photoionizing flux in the broad line region. I briefly discuss the main findings of this dissertation below. The optical and infrared (OIR) light curves and color variability diagrams for a sample of 12 blazars are presented. I analyze the OIR color variability of these blazars from 2011 - 2013, comparing their OIR properties to the jet state via Fermi gamma-ray fluxes obtained on a similar cadence. This project also assesses long-term color variability by extending the temporal baseline of 6 blazars to 5 years, allowing the comparison of the color variability in the same source at different jet states. Using the slope of the color variability diagram, we propose that the existing dichotomy between FSRQ (redder when brighter) and BLL (bluer when brighter) color variability be reconsidered as a continuum of jet (versus disk) activity, in which blazars can achieve either color variability response depending on jet power. This allows a self-consistent description of the changes in OIR color variability in the same source over time, as well as the OIR color variability in a sample of blazars over time. The second topic of the dissertation is the emission line variability properties of a sample of 7 blazars. We compare the emission line variability with Fermi gamma-ray flux and optical linear polarized flux to estimate its relationship to

  4. Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

    DEFF Research Database (Denmark)

    Nygaard, Rie; Hansen, Louise Valentin; Mokrosinski, Jacek

    2010-01-01

    Five highly conserved polar residues connected by a number of structural water molecules together with two rotamer micro-switches, TrpVI:13 and TyrVII:20, constitute an extended hydrogen bond network between the intracellular segments of TM-I, -II, -VI, and -VII of 7TM receptors. Molecular dynamics...... simulations showed that, although the fewer water molecules in rhodopsin were relatively movable, the hydrogen bond network of the beta2-adrenergic receptor was fully loaded with water molecules that were surprisingly immobilized between the two rotamer switches, both apparently being in their closed...... (AsnI:18, AspII:10, and AsnVII:13), whereas others (AsnVII:12 and AsnVII:16) located one helical turn apart and sharing a water molecule were shown to be essential for agonist-induced signaling. It is concluded that the conserved water hydrogen bond network of 7TM receptors constitutes an extended...

  5. Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Skouby, S O.; Andersen, L F

    2002-01-01

    BACKGROUND: Long-term hormone replacement therapy (HRT) reduces cardiovascular risk, but an early increased risk was reported in women with coronary heart disease. In such women the arterial intima can express tissue factor, and changes in coagulation factor VII (factor VII) and tissue factor...... pathway inhibitor (TFPI) may be deleterious. METHODS: We measured factor VII clotting activity, activated factor VII, and concentrations of factor VII and TFPI during 12 months in healthy post-menopausal women randomized to: (i). cyclic oral estrogen/progestin (n = 25); (ii). long-cycle oral estrogen...... after progestin intake. The integrated response, AUC, for TFPI was significantly lower in the HRT groups compared with the reference group. CONCLUSION: The observed changes may increase the early thrombotic risk associated with HRT use. Udgivelsesdato: 2002-Dec...

  6. Purification and characterization of adenovirus core protein VII: a histone-like protein that is critical for adenovirus core formation.

    Science.gov (United States)

    Sharma, Gaurav; Moria, Nithesh; Williams, Martin; Krishnarjuna, Bankala; Pouton, Colin W

    2017-07-01

    Adenovirus protein VII is a highly cationic core protein that forms a nucleosome-like structure in the adenovirus core by condensing DNA in combination with protein V and mu. It has been proposed that protein VII could condense DNA in a manner analogous to mammalian histones. Due to the lack of an expression and purification protocol, the interactions between protein VII and DNA are poorly understood. In this study we describe methods for the purification of biologically active recombinant protein VII using an E. coli expression system. We expressed a cleavable fusion of protein VII with thioredoxin and established methods for purification of this fusion protein in denatured form. We describe an efficient method for resolving the cleavage products to obtain pure protein VII using hydroxyapatite column chromatography. Mass spectroscopy data confirmed its mass and purity to be 19.4 kDa and >98 %, respectively. Purified recombinant protein VII spontaneously condensed dsDNA to form particles, as shown by dye exclusion assay, electrophoretic mobility shift assay and nuclease protection assay. Additionally, an in vitro bioluminescence assay revealed that protein VII can be used to enhance the transfection of mammalian cells with lipofectamine/DNA complexes. The availability of recombinant protein VII will facilitate future studies of the structure of the adenovirus core. Improved understanding of the structure and function of protein VII will be valuable in elucidating the mechanism of adenoviral DNA condensation, defining the morphology of the adenovirus core and establishing the mechanism by which adenoviral DNA enters the nucleus.

  7. UNVEILING THE NATURE OF THE UNIDENTIFIED GAMMA-RAY SOURCES. III. GAMMA-RAY BLAZAR-LIKE COUNTERPARTS AT LOW RADIO FREQUENCIES

    Energy Technology Data Exchange (ETDEWEB)

    Massaro, F.; Funk, S. [SLAC National Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); D' Abrusco, R.; Paggi, A. [Harvard-Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Giroletti, M. [INAF Istituto di Radioastronomia, via Gobetti 101, I-40129 Bologna (Italy); Masetti, N. [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129 Bologna (Italy); Tosti, G. [Dipartimento di Fisica, Universita degli Studi di Perugia, I-06123 Perugia (Italy); Nori, M. [Department of Physics and Astronomy, University of Bologna, viale Berti Pichat 6/2, I-40127 Bologna (Italy)

    2013-07-01

    About one-third of the {gamma}-ray sources listed in the second Fermi Large Area Telescope catalog (2FGL) have no firmly established counterpart at lower energies and so are classified as unidentified gamma-ray sources (UGSs). Here, we propose a new approach to find candidate counterparts for the UGSs based on the 325 MHz radio survey performed with the Westerbork Synthesis Radio Telescope in the northern hemisphere. First, we investigate the low-frequency radio properties of blazars, the largest known population of {gamma}-ray sources; then we search for sources with similar radio properties combining the information derived from the Westerbork Northern Sky Survey (WENSS) with those of the NRAO Very Large Array Sky Survey. We present a list of candidate counterparts for 32 UGSs with at least one counterpart in the WENSS. We also performed an extensive research in the literature to look for infrared and optical counterparts of the {gamma}-ray blazar candidates selected using the low-frequency radio observations to confirm their nature. On the basis of our multifrequency research, we identify 23 new {gamma}-ray blazar candidates out of the 32 UGSs investigated. Comparison with previous results on the UGSs is also presented. Finally, we speculate on the advantages of using low-frequency radio observations to associate UGSs and to search for {gamma}-ray pulsar candidates.

  8. NuSTAR and multifrequency study of the two high-redshift blazars S5 0836+710 and PKS 2149-306

    DEFF Research Database (Denmark)

    Tagliaferri, G.; Ghisellini, G.; Perri, M.

    2015-01-01

    Powerful blazars are flat-spectrum radio quasars whose emission is dominated by a Compton component peakingbetween a few hundred keV and a few hundred MeV. We observed two bright blazars, PKS 2149–306 at redshift z = 2.345 and S5 0836+710 at z = 2.172, in the hard X-ray band with the Nuclear...... of a few months. While no fast variability was detected during a single observation, both sources were variable in the X-ray band, up to 50%, between the two observations, with larger variability at higher energies. No variability was detected in the optical/NIR band. These data, together with Fermi......-Large Area Telescope, Wide-field Infrared Survey Explorer, and other literature data, are then used to study the overall spectral energy distributions (SEDs) of these blazars. Although the jet nonthermal emission dominates the SED, it leaves the UV band unhidden, allowing us to detect the thermal emission...

  9. Descriptive Analysis of Title VII-Funded State Education Agency Activities. Volume II: Nine Case Studies.

    Science.gov (United States)

    Nava, Hector; And Others

    Results of a national study of the use of funds provided by the 1974 amendments to Title VII of the Elementary and Secondary Education Act by the state education agencies (SEAs) are presented. The study was undertaken to (1) describe and analyze SEA policies and activities regarding bilingual education, (2) describe and analyze the SEA-level…

  10. Descriptive Analysis of Title VII-Funded State Education Agency Activities. Volume I.

    Science.gov (United States)

    Nava, Hector; And Others

    Results of a national study of the use of funds provided by the 1974 amendments to Title VII of the Elementary and Secondary Education Act by the state education agencies (SEAs) are presented. The study was undertaken to (1) describe and analyze SEA policies and activities regarding bilingual education, (2) describe and analyze the SEA-level…

  11. Settlement of Title VII Disputes: Shifting Patterns in a Changing World.

    Science.gov (United States)

    Bompey, Stuart H.; Witten, Richard E.

    1980-01-01

    An overview is given of the mechanics of dispute resolution under Title VII of the Civil Rights Act of 1964. Described and analyzed are the various stages during the processing of a dispute when settlement is possible. The effects of Bakke and Weber decisions on the process are considered. (MSE)

  12. What history tells us VII. Twenty-five years ago: the production of ...

    Indian Academy of Sciences (India)

    2006-11-13

    Nov 13, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 5. What history tells us VII. Twenty-five years ago: the production of mouse embryonic stem cells. Michel Morange. Series Volume 31 Issue 5 December 2006 pp 537-541. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Analysis of time series for postal shipments in Regional VII East Java Indonesia

    Science.gov (United States)

    Kusrini, DE; Ulama, B. S. S.; Aridinanti, L.

    2018-03-01

    The change of number delivery goods through PT. Pos Regional VII East Java Indonesia indicates that the trend of increasing and decreasing the delivery of documents and non-documents in PT. Pos Regional VII East Java Indonesia is strongly influenced by conditions outside of PT. Pos Regional VII East Java Indonesia so that the prediction the number of document and non-documents requires a model that can accommodate it. Based on the time series plot monthly data fluctuations occur from 2013-2016 then the model is done using ARIMA or seasonal ARIMA and selected the best model based on the smallest AIC value. The results of data analysis about the number of shipments on each product sent through the Sub-Regional Postal Office VII East Java indicates that there are 5 post offices of 26 post offices entering the territory. The largest number of shipments is available on the PPB (Paket Pos Biasa is regular package shipment/non-document ) and SKH (Surat Kilat Khusus is Special Express Mail/document) products. The time series model generated is largely a Random walk model meaning that the number of shipment in the future is influenced by random effects that are difficult to predict. Some are AR and MA models, except for Express shipment products with Malang post office destination which has seasonal ARIMA model on lag 6 and 12. This means that the number of items in the following month is affected by the number of items in the previous 6 months.

  14. Vittorio De Sica viis meistritööd / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2008-01-01

    DVD-st "Vittorio De Sica Masterpiece Collection", kus on peal itaalia filmirežissööri Vittorio De Sica viis teost: "Jalgratavargad" ("Ladri di biciclette", 1948), "Ime Milanos" ("Miraclo a milano", 1951), "Umberto D." (1952), "Eile täna, homme" ("Ieri, oggi, domani", 1963), "Ajatu filmikunst" ("Cinema senza tempo: Cosi e la vita", 2001)

  15. Contribution of coagulation factor VII R353Q polymorphism to the ...

    African Journals Online (AJOL)

    Hanan Azzam

    2016-12-05

    Dec 5, 2016 ... Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study. Hanan Azzam a, Reham M. El-Farahaty a,*. , Nashwa K. Abousamra a, Hossam Elwakeel b, Sherif Sakr c,. Ayman Helmy c, Eman Khashaba d.

  16. Law School Faculty Hiring under Title VII: How a Judge Might Decide a Disparate Impact Case.

    Science.gov (United States)

    Redlich, Norman

    1991-01-01

    A judicial opinion concerning law school violations of Title VII of the Civil Rights Act of 1964 in faculty hiring is presented. The case concerns a black candidate rejected for an entry-level tenure-track position. Issues cited include the law school's mission and stated reasons for not hiring the candidate. (MSE)

  17. Cataloguing Emission Line Spectra from Fe VII-Fe XXIV in the Extreme Ultraviolet

    Science.gov (United States)

    Lepson, J. K.; Beiersdorfer, P.; Brown, G. V.; Kahn, D. A.; Liedahl, D. A.; Mauche, C. W.; Utter, S. B.

    2000-01-01

    Detailed laboratory astrophysics measurements are, in progress to produce spectral tables for the Fe VII Fe XXIV line emission in the EUV wavelength band. Results for Fe XIII are presented that update line lists used in the Chandra Emission Line Project.

  18. Contribution of coagulation factor VII R353Q polymorphism to the ...

    African Journals Online (AJOL)

    Background: Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders. It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele carriers were more associated with lower levels of FVII than R allele carriers. However, the association between ...

  19. Factor VII-activating protease in patients with acute deep venous thrombosis

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Vitzthum, Frank; Funding, Eva

    2008-01-01

    -PA, without affecting the ability to activate coagulation Factor VII (FVII). Previous studies have investigated the association of the 1601GA genotype with incidence and progression of carotid stenosis and deep venous thrombosis (DVT). The present study is the first to evaluate the potential association...

  20. Training Bilingual Teachers: A Look at the Title VII Graduate in the Field.

    Science.gov (United States)

    Clark, Ellen R.; Milk, Robert D.

    1983-01-01

    Describes follow-up survey of 71 graduates from University of Texas San Antonio's Title VII Bilingual Education training project. Findings support emphasis on extra-curricular training activities. Perceived areas of weakness include math and science methods. Overall, ex-trainees maintain strong positive attitudes toward bilingual education despite…

  1. A high fat meal activates blood coagulation factor VII in rats

    DEFF Research Database (Denmark)

    Olsen, Aage K; Bladbjerg, Else M; Hansen, Axel K

    2002-01-01

    In humans, high fat meals cause postprandial activation of blood coagulation factor VII (FVII), but human studies have not provided definite evidence for a prothrombotic effect of dietary FVII activation. An animal model would be an attractive way to pursue this question and therefore we tested...

  2. Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII

    DEFF Research Database (Denmark)

    Larsen, L F; Bladbjerg, E-M; Jespersen, J

    1997-01-01

    Acute elevation of the coagulant activity of blood coagulation factor VII (FVIIc) is observed after consumption of high-fat meals. This elevation is caused by an increase in the concentration of activated FVII (FVIIa). In a randomized crossover study, we investigated whether saturated...

  3. Presidendi teenetemärgi pälvis viis spordiinimest

    Index Scriptorium Estoniae

    2008-01-01

    Vt. ka Linnaleht : Tartu 7. veebr., lk. 7. Eesti riigile osutatud teenete eest pälvisid president Toomas Hendrik Ilveselt teenetemärgi viis spordieluga seotud inimest: jalgpallikoondise ekstreenerid Jelle Goes ja Arno Pijpers, kergejõustikutreener Vésteinn Hafsteinsson, sõudetreener Tatjana Jaanson ning spordielu edendaja Nora Kutti. Juuresoleval fotol Jelle Goes

  4. Factor VII-activating protease : Unraveling the release and regulation of dead cell nuclear damps

    NARCIS (Netherlands)

    Marsman, G.

    2017-01-01

    Upon inflammation, uncleared dying cells are an important source of pro-inflammatory damage-associated molecular patterns (DAMPs). Major DAMPs are histones and double-stranded DNA, which together form chromatin. Factor VII-activating protease (FSAP) is activated upon contact with dead cells, and its

  5. "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

    Index Scriptorium Estoniae

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest. Ka teistest festivalil auhinnasaajatest

  6. Eesti lavastus "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

    Index Scriptorium Estoniae

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest

  7. Dos Idiomas, Un Mundo. Dual Language Project. Title VII Biennial Evaluation Report, 1995-97.

    Science.gov (United States)

    Ernest, Harishini M.; Gonzalez, Rosa M.

    This is an evaluation of the first 2 years of a 5-year comprehensive Bilingual Education grant funded by Title VII Part A of the Improving America's Schools Act of 1994 in the Austin Independent School District (AISD) (Texas). The grant awarded to the AISD funds a program of Developmental Bilingual Education at two elementary schools where more…

  8. Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases

    Directory of Open Access Journals (Sweden)

    Licarete Emilia

    2012-04-01

    Full Text Available Abstract Background Autoimmunity to collagen VII is typically associated with the skin blistering disease epidermolysis bullosa acquisita (EBA, but also occurs occasionally in patients with systemic lupus erythematosus or inflammatory bowel disease. The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors. Methods Based on in silico antigenic analysis and previous wetlab epitope mapping data, we designed a chimeric collagen VII construct containing all collagen VII epitopes with higher antigenicity. ELISA was performed with sera from patients with EBA (n = 50, Crohn's disease (CD, n = 50, ulcerative colitis (UC, n = 50, bullous pemphigoid (BP, n = 76, and pemphigus vulgaris (PV, n = 42 and healthy donors (n = 245. Results By ELISA, the receiver operating characteristics analysis yielded an area under the curve of 0.98 (95% CI: 0.9638-1.005, allowing to set the cut-off at 0.32 OD at a calculated specificity of 98% and a sensitivity of 94%. Running the optimized test showed that serum IgG autoantibodies from 47 EBA (94%; 95% CI: 87.41%-100%, 2 CD (4%; 95% CI: 0%-9.43%, 8 UC (16%; 95% CI: 5.8%-26%, 2 BP (2.63%; 95% CI: 0%-6.23%, and 4 PV (9.52%; 95% CI: 0%-18.4% patients as well as from 4 (1.63%; 95% CI: 0%-3.21% healthy donors reacted with the chimeric protein. Further analysis revealed that in 34%, 37%, 16% and 100% of sera autoantibodies of IgG1, IgG2, IgG3, and IgG4 isotype, respectively, recognized the recombinant autoantigen. Conclusions Using a chimeric protein, we developed a new sensitive and specific ELISA to detect collagen specific antibodies. Our results show a low prevalence of collagen VII-specific autoantibodies in inflammatory bowel disease, pemphigus and bullous pemphigoid. Furthermore, we show that the autoimmune response against collagen VII is dominated by IgG4 autoantibodies. The new immunoassay should

  9. Uso de fator VII recombinante ativado para tratamento e profilaxia de grandes sangramentos Use of recombinant activated factor VII for treatment and prophylaxis of major bleeding

    Directory of Open Access Journals (Sweden)

    Flávio Augusto Henriques Vince

    2009-09-01

    Full Text Available INTRODUÇÃO: O fator VII recombinante ativado (rFVIIa é uma proteína produzida por engenharia genética, cuja estrutura é muito semelhante à do fator VII intrínseco ativado (FVII. Sua ação se baseia no conhecimento do mecanismo de coagulação in vivo agindo na ativação direta do fator X resultando em formação independente de trombina no local da lesão e contribuindo dessa forma para formação de coágulo estável de fibrina sem a ação dos fatores VIII e IX. MÉTODOS: Foi realizada ampla revisão da literatura com o objetivo de determinar os achados recentes relacionados ao uso de fator VII recombinante ativado em pacientes com sangramento severo. RESULTADOS: Constatou-se que o uso de rFVIIa foi iniciado na década de 80 para profilaxia e tratamento de sangramento em pacientes com antecedente de hemofilia A ou B com inibidores de fator VIII e IX, deficiência de fator VII e trombastenia de Glanzmann refratários à reposição plaquetária. Em 1999 seu uso foi ampliado para outras situações clínicas e dessa forma, começaram a ser publicados diversos trabalhos mostrando a eficácia do rFVIIa como agente pró-hemostático em paciente com outras coagulopatias ou pacientes previamente hígidos com história de sangramento agudo de grande monta. Trauma é a principal causa de mortalidade no mundo sendo sangramento incontrolado o principal desafio no atendimento a estes pacientes. É comum a associação de trauma com coagulopatia, necessitando em algumas situações de terapia específica para o tratamento da mesma. Neste momento a terapia adjuvante com rFVIIa deve ser considerada. Outras causas comuns de sangramento são as operações cardíacas e ginecológicas/ obstétricas e doenças envolvendo o fígado. A coagulopatia nesses casos ocorre por deficiência dos fatores dependentes de vitamina K, sendo o FVII o com menor meia-vida. CONCLUSÃO: O uso de rFVIIa tem sido sugerido como opção terapêutica promissora para esses

  10. Nuclear energy and astrophysics applications of ENDF/B-VII.1 evaluated nuclear library

    International Nuclear Information System (INIS)

    Pritychenko, B.

    2012-01-01

    Recently released ENDF/B-VII.1 evaluated nuclear library contains the most up-to-date evaluated neutron cross section and covariance data. These data provide new opportunities for nuclear science and astrophysics application development. The improvements in neutron cross section evaluations and more extensive utilization of covariance files, by the Cross Section Evaluation Working Group (CSEWG) collaboration, allowed users to produce neutron thermal cross sections, Westcott factors, resonance integrals, Maxwellian-averaged cross sections and astrophysical reaction rates, and provide additional insights on the currently available neutron-induced reaction data. Nuclear reaction calculations using the ENDF/B-VII.1 library and current computer technologies will be discussed and new results will be presented

  11. Uso de fator VII recombinante ativado para tratamento e profilaxia de grandes sangramentos

    OpenAIRE

    Vince,Flávio Augusto Henriques; Brandão,Maria José Nascimento

    2009-01-01

    INTRODUÇÃO: O fator VII recombinante ativado (rFVIIa) é uma proteína produzida por engenharia genética, cuja estrutura é muito semelhante à do fator VII intrínseco ativado (FVII). Sua ação se baseia no conhecimento do mecanismo de coagulação in vivo agindo na ativação direta do fator X resultando em formação independente de trombina no local da lesão e contribuindo dessa forma para formação de coágulo estável de fibrina sem a ação dos fatores VIII e IX. MÉTODOS: Foi realizada ampla revisão da...

  12. Sobre el envío de tropas de la Legio VII Gemina al limes africano

    Directory of Open Access Journals (Sweden)

    Juan José PALAO VICENTE

    2010-02-01

    Full Text Available RESUMEN: Las relaciones entre Hispania y Africa en época romana fueron corrientes en todos los campos, incluyendo el militar. Este artículo intenta analizar la presencia en territorio africano de tropas de la Legio VII Gemina, tratando de conocer cuáles fueron los verdaderos motivos de dicha estancia. El estudio del material amplía la visión tradicional de las posibles funciones allí desempeñadas por estos destacamentos, que posiblemente abarcaron aspectos administrativos y logísticos.ABSTRACT: The relationship between Hispania and Africa in the Roman world were very strong in alls fields incluiding the military, too. This paper purposes to analize the presence of legio VII Gemina's troops in African territories, attempting to know the true reasons of this presence.The study of material presents a new vision about the mission of those troops, which undertake possibly administratives and logistics works.

  13. Bulk moduli and equations of state of ice VII and ice VIII

    Science.gov (United States)

    Klotz, S.; Komatsu, K.; Kagi, H.; Kunc, K.; Sano-Furukawa, A.; Machida, S.; Hattori, T.

    2017-05-01

    The compression behavior of deuterated ice VII and VIII was investigated by high pressure neutron scattering in the pressure range 2-13.7 GPa between 93 and 300 K. We establish equations of state which contain accurate values for the bulk moduli B0, their pressure derivatives B0', as well as the ambient pressure volume V0. These equations of state hold over a large part of the stability domain of ice VII, by comparison with available x-ray data, and to at least ≈13 GPa for ice VIII. They are indistinguishable at low pressures, but beyond ≈7 GPa and at low temperatures ice VIII appears to become stiffer than expected. This might be related to an anomalous phonon hardening observed previously in ice VIII in this P /T range [D. D. Klug et al., Phys. Rev. B 70, 144113 (2004), 10.1103/PhysRevB.70.144113].

  14. Análise dos Resultados da VII Olimpíada Brasileira de Astronomia

    Science.gov (United States)

    Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Aguilera, Nuricel Villalonga; Preta Padilha, Maria De Fátima Catta; de Medeiros, José Renan; Dantas, Márcia Pragano; Roque da Silva, Adriana; Martins, Roberto Vieira; Dottori, Horácio Alberto; Maia, Márcio Antonio Geimba; Da Rocha Poppe, Paulo César; Rodrigues da Costa, Antônio Carlos

    2006-06-01

    In this work we show the results of the VII Brazilian Astronomy Olympiad (VII OBA), that occurred on 15/05/2004, in all previous registered elementary and high schools, public and/or private, urban and/or rural. Took part in this Olympiad 123.001 students (60,7 % more than VI OBA), distributed over 2.721 schools (increasing of 73% if compared with the VI OBA), belonging to all Brazilian states. The public schools are 75,5% and the private are 24,5%. The team of 4 students selected in the VI OBA (2003) represented the Brazil in the IX International Astronomy Olympiad (IX IAO), that occurred on October of 2004, in Ukraine and won a silver medal and two bronze medals.

  15. Department of Neurosurgery, Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial (K.E.M.) Hospital, Mumbai.

    Science.gov (United States)

    Pandya, Sunil; Goel, Atul

    2017-01-01

    Seth Gordhandas Sunderdas Medical College and King Edward VII Memorial (K.E.M.) Hospital, Mumbai were inaugurated in 1925. This article traces its illustrious history and of the eminent neurosurgeons who shaped its destiny.

  16. Release of the ENDF/B-VII.1 Evaluated Nuclear Data File

    Energy Technology Data Exchange (ETDEWEB)

    Brown, David

    2012-06-30

    The Cross Section Evaluation Working Group (CSEWG) released the ENDF/B-VII.1 library on December 22, 2011. The ENDF/B-VII.1 library is CSEWG's latest recommended evaluated nuclear data file for use in nuclear science and technology applications, and incorporates advances made in the five years since the release of ENDF/B-VII.0, including: many new evaluation in the neutron sublibrary (423 in all and over 190 of these contain covariances), new fission product yields and a greatly improved decay data sublibrary. This summary barely touches on the five years worth of advances present in the ENDF/B-VII.1 library. We expect that these changes will lead to improved integral performance in reactors and other applications. Furthermore, the expansion of covariance data in this release will allow for better uncertainty quantification, reducing design margins and costs. The ENDF library is an ongoing and evolving effort. Currently, the ENDF data community embarking on several parallel efforts to improve library management: (1) The adoption of a continuous integration system to provide evaluators 'instant' feedback on the quality of their evaluations and to provide data users with working 'beta' quality libraries in between major releases. (2) The transition to new hierarchical data format - the Generalized Nuclear Data (GND) format. We expect GND to enable new kinds of evaluated data which cannot be accommodated in the legacy ENDF format. (3) The development of data assimilation and uncertainty propagation techniques to enable the consistent use of integral experimental data in the evaluation process.

  17. Japanese contributions to IAEA INTOR workshop, phase two A, part 2 chapter VII: technical benefit

    International Nuclear Information System (INIS)

    Itoh, Shin-ichi; Iida, Hiromasa; Tomabechi, Ken; Tone, Tatsuzo; Fujisawa, Noboru.

    1985-07-01

    This report corresponds to Chapter VII of Japanese contribution report to IAEA INTOR Workshop, Phase Two A, Part 2. The purpose of technical benefit study is to examine the implications of having different manufacturers fabricate components of a major system of INTOR. A systematic examinations of advantages and disadvantages of designing and fabricating major INTOR components in the frame of one international joint projects is performed. (author)

  18. A Steady-state Spectral Model for Electron Acceleration and Cooling in Blazar Jets: Application to 3C 279

    Science.gov (United States)

    Lewis, Tiffany R.; Finke, Justin D.; Becker, Peter A.

    2018-01-01

    We introduce a new theoretical model to describe the emitting region in a blazar jet. We adopt a one-zone leptonic picture and construct the particle transport equation for a plasma blob experiencing low-energy, monoenergetic particle injection, energy-dependent particle escape, shock acceleration, adiabatic expansion, stochastic acceleration, synchrotron radiation, and external Compton radiation from the dust torus and broad-line region (BLR). We demonstrate that a one-zone leptonic model is able to explain the IR though γ -ray spectrum for 3C 279 in 2008–2009. We determine that the BLR seed photons cannot be adequately described by a single average distribution, but rather we find that a stratified BLR provides an improvement in the estimation of the distance of the emitting region from the black hole. We calculate that the jet is not always in equipartition between the particles and magnetic field and find that stochastic acceleration provides more energy to the particles than does shock acceleration, where the latter is also overshadowed by adiabatic losses. We further introduce a novel technique to implement numerical boundary conditions and determine the global normalization for the electron distribution, based on analysis of stiff ordinary differential equations. Our astrophysical results are compared with those obtained by previous authors.

  19. Historic doubts, conjectures, and the wanderings of a principal curiosity: Henry VII in the fabric of Strawberry Hill

    OpenAIRE

    Calè, Luisa

    2017-01-01

    This article explores the inscriptions and material metamorphoses of Henry VII in Horace Walpole’s ‘paper fabric’, a reversible world of writing, collecting, and book making. In Anecdotes of Painting in England (1762), Walpole celebrates the funerary monument of Henry VII by Pietro Torrigiano at Westminster Abbey. In Historic Doubts on the Life and Reign of King Richard the Third (1768) conjecture and speculation become methodological prompts to unveil the textual and architectural discontinu...

  20. Comparison of results from the MCNP criticality validation suite using ENDF/B-VI and preliminary ENDF/B-VII nuclear data

    Energy Technology Data Exchange (ETDEWEB)

    Mosteller, R. D. (Russell D.)

    2004-01-01

    The MCNP Criticality Validation Suite is a collection of 31 benchmarks taken from the International Handbook of Evaluated Criticality Safety Benchmark Experiments. MCNP5 calculations clearly demonstrate that, overall, nuclear data for a preliminary version of ENDFB-VII produce better agreement with the benchmarks in the suite than do corresponding data from ENDF/B-VI. Additional calculations identify areas where improvements in the data still are needed. Based on results for the MCNP Criticality Validation Suite, the Pre-ENDF/B-VII nuclear data produce substantially better overall results than do their ENDF/B-VI counterparts. The calculated values for k{sub eff} for bare metal spheres and for an IEU cylinder reflected by normal uranium are in much better agreement with the benchmark values. In addition, the values of k{sub eff} for the bare metal spheres are much more consistent with those for corresponding metal spheres reflected by normal uranium or water. In addition, a long-standing controversy about the need for an ad hoc adjustment to the {sup 238}U resonance integral for thermal systems may finally be resolved. On the other hand, improvements still are needed in a number of areas. Those areas include intermediate-energy cross sections for {sup 235}U, angular distributions for elastic scattering in deuterium, and fast cross sections for {sup 237}Np.

  1. Neutron radiation damage studies in the structural materials of a 500 MWe fast breeder reactor using DPA cross-sections from ENDF / B-VII.1

    Science.gov (United States)

    Saha, Uttiyoarnab; Devan, K.; Bachchan, Abhitab; Pandikumar, G.; Ganesan, S.

    2018-04-01

    The radiation damage in the structural materials of a 500 MWe Indian prototype fast breeder reactor (PFBR) is re-assessed by computing the neutron displacement per atom (dpa) cross-sections from the recent nuclear data library evaluated by the USA, ENDF / B-VII.1, wherein revisions were taken place in the new evaluations of basic nuclear data because of using the state-of-the-art neutron cross-section experiments, nuclear model-based predictions and modern data evaluation techniques. An indigenous computer code, computation of radiation damage (CRaD), is developed at our centre to compute primary-knock-on atom (PKA) spectra and displacement cross-sections of materials both in point-wise and any chosen group structure from the evaluated nuclear data libraries. The new radiation damage model, athermal recombination-corrected displacement per atom (arc-dpa), developed based on molecular dynamics simulations is also incorporated in our study. This work is the result of our earlier initiatives to overcome some of the limitations experienced while using codes like RECOIL, SPECTER and NJOY 2016, to estimate radiation damage. Agreement of CRaD results with other codes and ASTM standard for Fe dpa cross-section is found good. The present estimate of total dpa in D-9 steel of PFBR necessitates renormalisation of experimental correlations of dpa and radiation damage to ensure consistency of damage prediction with ENDF / B-VII.1 library.

  2. A new approach for rhenium(VII) recovery by using modified brown algae Laminaria japonica adsorbent.

    Science.gov (United States)

    Xiong, Ying; Xu, Jia; Shan, Weijun; Lou, Zhenning; Fang, Dawei; Zang, Shuliang; Han, Guangxi

    2013-01-01

    Brown algae Laminaria japonica was chemically modified with sulfuric acid to obtain a crosslinked brown algae gel (CAS). The CAS gel showed a high affinity for Re(VII) comparing with other biomass gels, and the maximum adsorption capacity was evaluated as 37.20 mg g(-1) in case of pH 6, which could be explained by their different adsorption mechanisms. The adsorption equilibrium, kinetics and thermodynamic study for Re(VII) on the CAS gel was discussed in detail by the several models, such as Langmuir, Freundlich, Temkin and Dubinin-Radushkevich model for kinetics analysis, the pseudo first, the second-order, the Elovich and intraparticle diffusion equation for equilibrium analysis. Reutilization of the CAS gel was confirmed up to three adsorption-elution cycles in column-mode operation with no damage of gel, packed in the column. The result also provides a new approach for the recovery of Re(VII) from Re-containing wastewater by using the modified brown algae gel. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH DAN PENGEMBANGAN KARAKTER PADA SISWA KELAS VII MELALUI MODEL PBL BERBANTUAN SCAFFOLDING

    Directory of Open Access Journals (Sweden)

    Novy Kris Zaini

    2016-04-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat mencapai KKM yang ditetapkan, (2 apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat meningkatkan kemampuan pemecahan masalah peserta didik pilihan, (3 apakah pembelajaran matematika dengan model PBL berbantuan scaffolding pada materi pokok segiempat kelas VII dapat meningkatkan karakter rasa ingin tahu peserta didik pilihan. Desain penelitian ini adalah concurrent triangulation (campuran kuatitatif dan kualitatif secara seimbang, menggabungkan antara metode kuantitatif dan metode kualitatif untuk digunakan secara bersama-sama dalam suatu kegiatan penelitian, sehingga diperoleh data yang lebih komprehensif, valid, reliabel dan obyektif. Penentuan sumber data dalam penelitian ini menggunakan teknik triangulasi, yaitu menggabungkan dari berbagai teknik pengumpulan data dan sumber data yang telah ada. Data diperoleh dengan observasi, wawancara, dan dokumentasi yang kemudian dianalisis menggunakan analisis kualitatif, sedangkan tes dan observasi dianalisis menggunakan analisis kuantitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter rasa ingin tahu dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran PBL

  4. MENDF71x. Multigroup Neutron Cross Section Data Tables Based upon ENDF/B-VII.1

    International Nuclear Information System (INIS)

    Conlin, Jeremy Lloyd; Parsons, Donald Kent; Gardiner, Steven J.; Gray, Mark Girard; Lee, Mary Beth; White, Morgan Curtis

    2015-01-01

    A new multi-group neutron cross section library has been released along with the release of NDI version 2.0.20. The library is named MENDF71x and is based upon the evaluations released in ENDF/B-VII.1 which was made publicly available in December 2011. ENDF/B-VII.1 consists of 423 evaluations of which ten are excited states evaluations and 413 are ground state evaluations. MENDF71x was created by processing the 423 evaluations into 618-group, downscatter only NDI data tables. The ENDF/B evaluation files were processed using NJOY version 99.393 with the exception of 35 Cl and 233 U. Those two isotopes had unique properties that required that we process the evaluation using NJOY version 2012. The MENDF71x library was only processed to room temperature, i.e., 293.6 K. In the future, we plan on producing a multi-temperature library based on ENDF/B-VII.1 and compatible with MENDF71x.

  5. Keefektivan PMRI Berbantuan Alat Peraga Terhadap Kemampuan Pemecahan Masalah Serupa PISA Pada Kelas VII

    Directory of Open Access Journals (Sweden)

    Riyanto Riyanto

    2014-06-01

    Full Text Available AbstrakTujuan penelitian ini untuk mengetahui keefektivan pembelajaran dengan metode Pendidi-kan Matematika Realistik Indonesia (PMRI berbantuan alat peraga terhadap kemampuan pemecahan masalah serupa PISA siswa pada materi segiempat. Populasi dalam penelitian ini adalah siswa kelas VII SMP Negeri 3 Ungaran tahun pelajaran 2012/2013. Pemilihan sampel dengan cara random sampling, diperoleh siswa kelas VII-I dan siswa kelas VII-J se-bagai kelas eksperimen dan kelas kontrol. Kelas eksperimen diajar dengan metode PMRI berbantuan alat peraga, sedangkan kelas kontrol diajar dengan metode ekspositori. Data di-peroleh dengan metode observasi untuk mengamati aktivitas belajar guru dan metode tes untuk menentukan hasil belajar siswa yang kemudian dianalisis dengan uji ketuntasan dan uji perbedaan rata-rata: uji satu pihak (pihak kanan. Hasil penelitian adalah (1 hasil be-lajar siswa kelas eksperimen belum mencapai kriteria ketuntasan klasikal, (2 rata-rata ke-mampuan pemecahan masalah serupa PISA kelas eksperimen lebih baik dari kelas kontrol, dan (3 skor rata-rata aktivitas guru kelas ekperimen dan kelas kontrol memiliki kategori baik. Kata kunci:       Kualitas Pembelajaran; PISA; PMRI.  AbstractThe purpose of this research was to determine the effectiveness of learning by Teams Pendidikan Matematika Realistik Indonesia (PMRI assisted on figure tools to the problem solving skills PISA student on quadrilateral material. The population in this study is student of VIIth grade class of 3 Ungaran junior high school on period 2012/2013. The selection of the sample is done by random sampling which is gotten students class VII-I and students class VII-J as the experimental class and the controlling class. Experimental class was taught by PMRI assisted on figure tools, while the controlling class was taught with the expository method. Data obtained by the observation method to observe the activities of teacher learning and test methods for determining

  6. ZZ POINT-2007, linearly interpolable ENDF/B-VII.0 data for 14 temperatures

    International Nuclear Information System (INIS)

    Cullen, Dermott E.

    2007-01-01

    A - Description or function: The ENDF/B data library, ENDF/B-VII.0 was processed into the form of temperature dependent cross sections. The original evaluated data include cross sections represented in the form of a combination of resonance parameters and/or tabulated energy dependent cross sections, nominally at 0 Kelvin temperature. For use in applications, these ENDF/B-VII.0 data were processed into the form of temperature dependent cross sections at eight temperatures: 0, 300, 600, 900, 1200, 1500, 1800 and 2100 Kelvin. It has also been processed to six astrophysics like temperatures: 0.1, 1, 10, 100 eV, 1 and 10 keV. At each temperature the cross sections are tabulated and linearly interpolable in energy with a tolerance of 0.1 %. POINT 2007 contains all of the evaluations in the ENDF/B-VII general purpose library, which contains 78 new evaluations + 315 old ones: total 393 nuclides. It also includes 16 new elemental evaluations replaced by isotopic evaluations + 19 old ones. No special purpose ENDF/B-VII libraries, such as fission products, thermal scattering, photon interaction data are included. These evaluations include all cross sections over the energy range 10 e-5 eV to at least 20 MeV. The list of nuclides is indicated. B - Methods: The PREPRO 2007 code system was used to process the ENDF/B data. Listed below are the steps, including the PREPRO2007 codes, which were used to process the data in the order in which the codes were run. 1) Linearly interpolable, tabulated cross sections (LINEAR) 2) Including the resonance contribution (RECENT) 3) Doppler broaden all cross sections to temperature (SIGMA1) 4) Check data, define redundant cross sections by summation (FIXUP) 5) Update evaluation dictionary in MF/MT=1/451 (DICTIN) C - Restrictions: Due to recent changes in ENDF-6 Formats and Procedures only the latest version of the ENDF/B Pre-processing codes, namely PREPRO 2007, can be used to accurately process all current ENDF/B-VII evaluations. The use of

  7. Multifrequency Photo-polarimetric WEBT Observation Campaign on the Blazar S5 0716+714: Source Microvariability and Search for Characteristic Timescales

    Science.gov (United States)

    Bhatta, G.; Stawarz, Ł.; Ostrowski, M.; Markowitz, A.; Akitaya, H.; Arkharov, A. A.; Bachev, R.; Benítez, E.; Borman, G. A.; Carosati, D.; Cason, A. D.; Chanishvili, R.; Damljanovic, G.; Dhalla, S.; Frasca, A.; Hiriart, D.; Hu, S.-M.; Itoh, R.; Jableka, D.; Jorstad, S.; Jovanovic, M. D.; Kawabata, K. S.; Klimanov, S. A.; Kurtanidze, O.; Larionov, V. M.; Laurence, D.; Leto, G.; Marscher, A. P.; Moody, J. W.; Moritani, Y.; Ohlert, J. M.; Di Paola, A.; Raiteri, C. M.; Rizzi, N.; Sadun, A. C.; Sasada, M.; Sergeev, S.; Strigachev, A.; Takaki, K.; Troitsky, I. S.; Ui, T.; Villata, M.; Vince, O.; Webb, J. R.; Yoshida, M.; Zola, S.

    2016-11-01

    Here we report on the results of the Whole Earth Blazar Telescope photo-polarimetric campaign targeting the blazar S5 0716+71, organized in 2014 March to monitor the source simultaneously in BVRI and near-IR filters. The campaign resulted in an unprecedented data set spanning ∼110 hr of nearly continuous, multiband observations, including two sets of densely sampled polarimetric data mainly in the R filter. During the campaign, the source displayed pronounced variability with peak-to-peak variations of about 30% and “bluer-when-brighter” spectral evolution, consisting of a day-timescale modulation with superimposed hour-long microflares characterized by ∼0.1 mag flux changes. We performed an in-depth search for quasi-periodicities in the source light curve; hints for the presence of oscillations on timescales of ∼3 and ∼5 hr do not represent highly significant departures from a pure red-noise power spectrum. We observed that, at a certain configuration of the optical polarization angle (PA) relative to the PA of the innermost radio jet in the source, changes in the polarization degree (PD) led the total flux variability by about 2 hr; meanwhile, when the relative configuration of the polarization and jet angles altered, no such lag could be noted. The microflaring events, when analyzed as separate pulse emission components, were found to be characterized by a very high PD (>30%) and PAs that differed substantially from the PA of the underlying background component, or from the radio jet positional angle. We discuss the results in the general context of blazar emission and energy dissipation models. ).

  8. MULTIFREQUENCY PHOTO-POLARIMETRIC WEBT OBSERVATION CAMPAIGN ON THE BLAZAR S5 0716+714: SOURCE MICROVARIABILITY AND SEARCH FOR CHARACTERISTIC TIMESCALES

    Energy Technology Data Exchange (ETDEWEB)

    Bhatta, G.; Stawarz, Ł.; Ostrowski, M. [Astronomical Observatory of Jagiellonian University, ul. Orla 171, 30-244 Krakow (Poland); Markowitz, A. [Center for Astrophysics and Space Sciences, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0424 (United States); Akitaya, H. [Hiroshima Astrophysical Science Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Arkharov, A. A. [Main (Pulkovo) Astronomical Observatory of RAS, Pulkovskoye shosse, 60, 196140 St. Petersburg (Russian Federation); Bachev, R. [Institute of Astronomy, Bulgarian Academy of Sciences, 72, Tsarigradsko Shosse Blvd., 1784 Sofia (Bulgaria); Benítez, E. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Mexico DF (Mexico); Borman, G. A. [Crimean Astrophysical Observatory, P/O Nauchny, Crimea, 298409 (Russian Federation); Carosati, D. [EPT Observatories, Tijarafe, La Palma (Spain); Cason, A. D. [Private address, 105 Glen Pine Trail, Dawnsonville, GA 30534 (United States); Chanishvili, R. [Abastumani Observatory, Mt. Kanobili, 0301 Abastumani, Georgia (United States); Damljanovic, G. [Astronomical Observatory, Volgina 7, 11060 Belgrade (Serbia); Dhalla, S. [Florida International University, Miami, FL 33199 (United States); Frasca, A. [INAF—Osservatorio Astrofisico di Catania (Italy); Hiriart, D. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Ensenada (Mexico); Hu, S-M., E-mail: gopalbhatta716@gmail.com [Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment, Institute of Space Sciences, Shandong University at Weihai, 264209 Weihai (China); and others

    2016-11-01

    Here we report on the results of the Whole Earth Blazar Telescope photo-polarimetric campaign targeting the blazar S5 0716+71, organized in 2014 March to monitor the source simultaneously in BVRI and near-IR filters. The campaign resulted in an unprecedented data set spanning ∼110 hr of nearly continuous, multiband observations, including two sets of densely sampled polarimetric data mainly in the R filter. During the campaign, the source displayed pronounced variability with peak-to-peak variations of about 30% and “bluer-when-brighter” spectral evolution, consisting of a day-timescale modulation with superimposed hour-long microflares characterized by ∼0.1 mag flux changes. We performed an in-depth search for quasi-periodicities in the source light curve; hints for the presence of oscillations on timescales of ∼3 and ∼5 hr do not represent highly significant departures from a pure red-noise power spectrum. We observed that, at a certain configuration of the optical polarization angle (PA) relative to the PA of the innermost radio jet in the source, changes in the polarization degree (PD) led the total flux variability by about 2 hr; meanwhile, when the relative configuration of the polarization and jet angles altered, no such lag could be noted. The microflaring events, when analyzed as separate pulse emission components, were found to be characterized by a very high PD (>30%) and PAs that differed substantially from the PA of the underlying background component, or from the radio jet positional angle. We discuss the results in the general context of blazar emission and energy dissipation models.

  9. Long-Term Multi-Band and Polarimetric View of Mkn 421: Motivations for an Integrated Open-Data Platform for Blazar Optical Polarimetry

    Directory of Open Access Journals (Sweden)

    Ulisses Barres de Almeida

    2017-11-01

    Full Text Available In this work, by making use of the large software and database resources made available through online facilities such as the ASI Science Data Center (ASDC, we present a novel approach to the modelling of blazar emission whereby the multi-epoch SED for Mkn 421 is modelled considering, in a self-consistent way, the temporal lags between bands (both in short and long-timescales. These are obtained via a detailed cross-correlation analysis, spanning data from radio to VHE gamma-rays from 2008 to 2015. In addition to that, long-term optical polarisation data is used to aid and complement our physical interpretation of the state and evolution of the source. Blazar studies constitute a clear example that astrophysics is becoming increasingly dominated by “big data”. Specific questions, such as the interpretation of polarimetric information—namely the evolution of the polarisation degree (PD and specially the polarisation angle (PA of a source—are very sensitive to the density of data coverage. Improving data accessibility and integration, in order to respond to these necessities, is thus extremely important and has a potentially large impact for blazar science. For this reason, we present also the project to create an open-access database for optical polarimetry, aiming to circumvent the issues raised above, by integrating long-term optical polarisation information on a number sources from several observatories and data providers in a consistent way. The platform, to be launched by the end of 2017 is built as part of the Brazilian Science Data Center (BSDC, a project hosted at CBPF, in Rio de Janeiro, and developed with the support of the Italian Space Agency (ASI and ICRANet. The BSDC is Virtual Observatory-compliant and is built in line with “Open Universe”, a global space science open-data initiative to be launched in November under the auspices of the United Nations.

  10. Development and verification of a 281-group WIMS-D library based on ENDF/B-VII.1

    International Nuclear Information System (INIS)

    Dong, Zhengyun; Wu, Jun; Ma, Xubo; Yu, Hui; Chen, Yixue

    2016-01-01

    Highlights: • A new WIMS-D library based on SHEM 281 energy structures is developed. • The method for calculating the lambda factor is illustrated and parameters are discussed. • The results show the improvements of this library compared with other libraries. - Abstract: The WIMS-D library based on WIMS 69 or XMAS 172 energy group structures is widely used in thermal reactor research. Otherwise, the resonance overlap effect is not taken into account in the two energy group structure, which limits the accuracy of resonance treatment. The SHEM 281 group structure is designed by the French to avoid the resonance overlap effect. In this study, a new WIMS-D library with SHEM 281 mesh is developed by using the NJOY nuclear data processing system based on the latest Evaluated Nuclear Data Library ENDF/B-VII.1. The parameters such as the thermal cut-off energy and lambda factor that depend on group structure are discussed. The lambda factor is calculated by Neutron Resonance Spectrum Calculation System and the effect of this factor is analyzed. The new library is verified through the analysis of various criticality benchmarks by using DRAGON code. The values of multiplication factor are consistent with the experiment data and the results also are improved in comparison with other WIMS libraries.

  11. Non-stationary emission of the blazar S4 0954+658 over a wide range of wavelength

    Science.gov (United States)

    Volvach, A. E.; Bychkova, V. S.; Larionov, M. G.; Kardashev, N. S.; Volvach, L. N.; Vlasyuk, V. V.; Spiridonova, O. I.; Lähteenmäki, A.; Tornikoski, M.; Aller, M. F.; Aller, H. D.; Pooley, G.; Carrasco, L.; Porras, A.; Recillas, E.

    2016-12-01

    Data from long-term multi-frequency monitoring are used to analyze variations in the flux density of the active galactic nucleus S4 0954+658. These data were obtained at the CrimeanAstrophysical Observatory, the Metsähovi Radio Observatory of Aalto University, the University of Michigan Radio Astronomy Observatory, the Cavendish Laboratory of Cambridge University, the Special Astrophysical Observatory, and the National Institute of Astrophysics, Optics, and Electronics; 0.1-300-GeV data from the Fermi space gamma-ray observatory were also used. Radio data at 4.8, 8, 14.5, 15, 22.2, and 36.8 GHz are considered together with optical and near-infrared data in the R, J, H, and K filters. In the framework of a model in which binary supermassive black holes (SMBHs) are present in active galactic nuclei, harmonic and structural analyses are carried out to establish the orbital ( T orb ≈ 780 yrs) and precessional ( T pr ≈ 7800 yrs) periods in the rest frame of the source. The development of the most powerful flare ever observed in this object, which occurred in February 2015, is considered. The delay in the flare's development in different wavelength ranges from the gamma-ray to the radio is determined. both the magnitude of the delays and the durations of the flares themselves suggest that the physical characteristics of S4 0954+658 are similar to those of the blazar S5 0716+714, which displays evidence of a high γ factor for the jet motion and high superluminal speeds in the jet. The masses of the components of the binary SMBH ( M and m), the dimensions of their orbit, and the velocity of the lower-mass SMBH about the central SMBH are estimated. The derived physical characteristics are subject to a comparative analysis.

  12. LONG-TERM OPTICAL POLARIZATION VARIABILITY OF THE TeV BLAZAR 1ES 1959+650

    Energy Technology Data Exchange (ETDEWEB)

    Sorcia, Marco; Benitez, Erika; Cabrera, Jose I. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apdo. 70-264, Mexico D.F. 04510 (Mexico); Hiriart, David; Lopez, Jose M. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apdo. 810, Ensenada, B.C. 22800 (Mexico); Mujica, Raul [Instituto Nacional de Astrofisica, Optica y Electronica, Apdo. Postal 51 y 216, 72000 Tonantzintla, Puebla (Mexico); Heidt, Jochen; Mommert, Michael [ZAH, Landessternwarte Heidelberg, Koenigstuhl, D-69117 Heidelberg (Germany); Agudo, Ivan [Instituto Nacional de Astrofisica de Andalucia, CSIC, Apartado 3004, E-18080 Granada (Spain); Nilsson, Kari, E-mail: msorcia@astro.unam.mx [Finnish Centre for Astronomy with ESO (FINCA), University of Turku, Vaeisaelaentie 20, FI-21500 Piikkioe (Finland)

    2013-06-01

    A detailed analysis of the optical polarimetric variability of the TeV blazar 1ES 1959+650 from 2007 October 18 to 2011 May 5 is presented. The source showed maximum and minimum brightness states in the R band of 14.08 {+-} 0.03 mag and 15.20 {+-} 0.03 mag, respectively, with a maximum variation of 1.12 mag, and a maximum polarization degree of P = (12.2 {+-} 0.7)%, with a maximum variation of 10.7%. From 2009 August to November, a correlation between the optical R-band flux and the degree of linear polarization was found with a correlation coefficient r {sub pol} = 0.984 {+-} 0.025. The source presented a preferential position angle of optical polarization of {approx}153 Degree-Sign , with variations of 10 Degree-Sign -50 Degree-Sign , which is in agreement with the projected position angle of the parsec-scale jet found at 43 GHz. From the Stokes parameters we infer the existence of two optically thin synchrotron components that contribute to the polarized flux. One of them is stable with a constant polarization degree of 4%. Assuming a stationary shock for the variable component, we estimated some parameters associated with the physics of the relativistic jet: the magnetic field, B {approx} 0.06 G, the Doppler factor, {delta}{sub 0} {approx} 23, the viewing angle, {Phi} {approx} 2. Degree-Sign 4, and the size of the emission region r{sub b} {approx} 5.6 Multiplication-Sign 10{sup 17} cm. Our study is consistent with the spine-sheath model of explaining the polarimetric variability displayed by this source during our monitoring.

  13. Gamma-Ray Flaring Activity from the Gravitationally Lensed Blazar PKS 1830-211 Observed by Fermi LAT

    Energy Technology Data Exchange (ETDEWEB)

    Abdo, A. A.; et al.

    2015-01-23

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830–211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 10(50) erg s(–)(1), makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830–211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

  14. Optimizing Cr(VI) and Tc(VII) remediation through nano-scale biomineral engineering

    Energy Technology Data Exchange (ETDEWEB)

    Cutting, R. S.; Coker, V. S.; Telling, N. D.; Kimber, R. L.; Pearce, C. I.; Ellis, B.; Lawson, R; van der Laan, G.; Pattrick, R.A.D.; Vaughan, D.J.; Arenholz, E.; Lloyd, J. R.

    2009-09-09

    To optimize the production of biomagnetite for the bioremediation of metal oxyanion contaminated waters, the reduction of aqueous Cr(VI) to Cr(III) by two biogenic magnetites and a synthetic magnetite was evaluated under batch and continuous flow conditions. Results indicate that nano-scale biogenic magnetite produced by incubating synthetic schwertmannite powder in cell suspensions of Geobacter sulfurreducens is more efficient at reducing Cr(VI) than either biogenic nano-magnetite produced from a suspension of ferrihydrite 'gel' or synthetic nano-scale Fe{sub 3}O{sub 4} powder. Although X-ray Photoelectron Spectroscopy (XPS) measurements obtained from post-exposure magnetite samples reveal that both Cr(III) and Cr(VI) are associated with nanoparticle surfaces, X-ray Magnetic Circular Dichroism (XMCD) studies indicate that some Cr(III) has replaced octahedrally coordinated Fe in the lattice of the magnetite. Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) measurements of total aqueous Cr in the associated solution phase indicated that, although the majority of Cr(III) was incorporated within or adsorbed to the magnetite samples, a proportion ({approx}10-15 %) was released back into solution. Studies of Tc(VII) uptake by magnetites produced via the different synthesis routes also revealed significant differences between them as regards effectiveness for remediation. In addition, column studies using a {gamma}-camera to obtain real time images of a {sup 99m}Tc(VII) radiotracer were performed to visualize directly the relative performances of the magnetite sorbents against ultra-trace concentrations of metal oxyanion contaminants. Again, the magnetite produced from schwertmannite proved capable of retaining more ({approx}20%) {sup 99m}Tc(VII) than the magnetite produced from ferrihydrite, confirming that biomagnetite production for efficient environmental remediation can be fine-tuned through careful selection of the initial Fe(III) mineral

  15. PENGEMBANGAN LKS BERBASIS PROJECT BASED LEARNING UNTUK PEMBELAJARAN MATERI SEGITIGA DI KELAS VII

    Directory of Open Access Journals (Sweden)

    Dian Novita

    2016-06-01

    Full Text Available Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk (1mengetahui karakteristik LKS berbasis Project Based Learning (PjBL yang valid dan praktis dalam pembelajaran materi segitiga di kelas VII; (2mengetahui efek potensial penggunaan LKS berbasis PjBL terhadap hasil belajar siswa dalam pembelajaran materi segitiga di kelas VII. Metode penelitian pengembangan yang digunakan adalah model  ADDIE (Analysis, Design, Development, Implementation, and Evaluation. Teknik pengumpulan data yang digunakan adalah walkthrough, tes hasil belajar dan angket. Dari tes hasil belajar, diperoleh bahwa sebesar 82,5% siswa telah mencapai kategori tuntas dan 17,5% belum tuntas dengan KKM 75. Hasil angket respon siswa menunjukkan bahwa untuk pelaksanaan pembelajaran menggunakan LKS berbasis PjBL telah mencapai kriteria kepraktisan. Kemudian untuk LKS berbasis PjBL yang telah didesain, divalidasi oleh beberapa pakar, kemudian direvisi berdasarkan saran dari para pakar tersebut. LKS yang telah direvisi tersebut dianggap telah memenuhi kriteria kevalidan dan kepraktisan sehingga dapat digunakan dalam pembelajaran materi segitiga di kelas VII. Kesimpulan dari penelitian ini adalah (1 LKS bebasis PjBL yang dikembangkan valid, tergambar dari konten (sesuai dengan kurikulum untuk materi segitiga, konstruk (sesuai dengan prinsip PjBL, dan bahasa (sesuai dengan ejaan yang disempurnakan (EYD. Kepraktisan tergambar dari proses kerja siswa dalam melaksanakan LKS dan hasil angket respon siswa terhadap pembelajaran menggunakan LKS berbasis PjBL; (2 dari hasil latihan yang dikerjakan oleh siswa, LKS berbasis PjBL memiliki efek potensial terhadap hasil belajar, yakni sebanyak 33 siswa termasuk kategori tuntas (82,5% dan 7 orang belum tuntas (17,5%, dengan KKM 75. Kata Kunci : LKS, Project Based Learning DOI: http://dx.doi.org/10.22342/jpm.10.2.3626.1-12

  16. POINT 2011: ENDF/B-VII.1 Beta2 Temperature Dependent Cross Section Library

    International Nuclear Information System (INIS)

    Cullen, D.E.

    2011-01-01

    This report is one in the series of 'POINT' reports that over the years have presented temperature dependent cross sections for the then current version of ENDF/B. In each case I have used my personal computer at home and publicly available data and codes. I have used these in combination to produce the temperature dependent cross sections used in applications and presented in this report. I should mention that today anyone with a personal computer can produce these results. The latest ENDF/B-VII.1 beta2 data library was recently and is now freely available through the National Nuclear Data Center (NNDC), Brookhaven National Laboratory. This release completely supersedes all preceding releases of ENDF/B. As distributed the ENDF/B-VII.1 data includes cross sections represented in the form of a combination of resonance parameters and/or tabulated energy dependent cross sections, nominally at 0 Kelvin temperature. For use in our applications the ENDF/B-VII.1 library has been processed into cross sections at eight neutron reactor like temperatures, between 0 and 2100 Kelvin, in steps of 300 Kelvin (the exception being 293.6 Kelvin, for exact room temperature at 20 Celsius). It has also been processed to five astrophysics like temperatures, 1, 10, 100 eV, 1 and 10 keV. For reference purposes, 300 Kelvin is approximately 1/40 eV, so that 1 eV is approximately 12,000 Kelvin. At each temperature the cross sections are tabulated and linearly interpolable in energy. All results are in the computer independent ENDF-6 character format (R2), which allows the data to be easily transported between computers. In its processed form the POINT 2011 library is approximately 16 gigabyte in size and is distributed on one compressed DVDs (see, below for the details of the contents of each DVD).

  17. POINT 2011: ENDF/B-VII.1 Beta2 Temperature Dependent Cross Section Library

    Energy Technology Data Exchange (ETDEWEB)

    Cullen, D E

    2011-04-07

    This report is one in the series of 'POINT' reports that over the years have presented temperature dependent cross sections for the then current version of ENDF/B. In each case I have used my personal computer at home and publicly available data and codes. I have used these in combination to produce the temperature dependent cross sections used in applications and presented in this report. I should mention that today anyone with a personal computer can produce these results. The latest ENDF/B-VII.1 beta2 data library was recently and is now freely available through the National Nuclear Data Center (NNDC), Brookhaven National Laboratory. This release completely supersedes all preceding releases of ENDF/B. As distributed the ENDF/B-VII.1 data includes cross sections represented in the form of a combination of resonance parameters and/or tabulated energy dependent cross sections, nominally at 0 Kelvin temperature. For use in our applications the ENDF/B-VII.1 library has been processed into cross sections at eight neutron reactor like temperatures, between 0 and 2100 Kelvin, in steps of 300 Kelvin (the exception being 293.6 Kelvin, for exact room temperature at 20 Celsius). It has also been processed to five astrophysics like temperatures, 1, 10, 100 eV, 1 and 10 keV. For reference purposes, 300 Kelvin is approximately 1/40 eV, so that 1 eV is approximately 12,000 Kelvin. At each temperature the cross sections are tabulated and linearly interpolable in energy. All results are in the computer independent ENDF-6 character format [R2], which allows the data to be easily transported between computers. In its processed form the POINT 2011 library is approximately 16 gigabyte in size and is distributed on one compressed DVDs (see, below for the details of the contents of each DVD).

  18. Constraining the Milky Way's Hot Gas Halo with O VII and O VIII Emission Lines

    Science.gov (United States)

    Miller, Matthew J.; Bregman, Joel N.

    2015-02-01

    The Milky Way hosts a hot (≈2 × 106 K), diffuse, gaseous halo based on detections of z = 0 O VII and O VIII absorption lines in quasar spectra and emission lines in blank-sky spectra. Here we improve constraints on the structure of the hot gas halo by fitting a radial model to a much larger sample of O VII and O VIII emission line measurements from XMM-Newton/EPIC-MOS spectra compared to previous studies (≈650 sightlines). We assume a modified β-model for the halo density distribution and a constant-density Local Bubble from which we calculate emission to compare with the observations. We find an acceptable fit to the O VIII emission line observations with χ 2red (dof) = 1.08 (644) for best-fit parameters of no r_c3β = 1.35 +/- 0.24 cm-3 kpc3β and β = 0.50 ± 0.03 for the hot gas halo and negligible Local Bubble contribution. The O VII observations yield an unacceptable χ 2red (dof) = 4.69 (645) for similar best-fit parameters, which is likely due to temperature or density variations in the Local Bubble. The O VIII fitting results imply hot gas masses of M(properties, temperature and entropy gradients in the halo gas, and the gas metallicity distribution. The combination of absorption and emission line analyses implies a sub-solar gas metallicity that decreases with radius, but that also must be >=0.3 Z ⊙ to be consistent with the pulsar dispersion measure toward the Large Magellanic Cloud.

  19. Optimizing Cr(VI) and Tc(VII) remediation through nano-scale biomineral engineering

    International Nuclear Information System (INIS)

    Cutting, R.S.; Coker, V.S.; Telling, N.D.; Kimber, R.L.; Pearce, C.I.; Ellis, B.; Lawson, R; van der Laan, G.; Pattrick, R.A.D.; Vaughan, D.J.; Arenholz, E.; Lloyd, J.R.

    2009-01-01

    To optimize the production of biomagnetite for the bioremediation of metal oxyanion contaminated waters, the reduction of aqueous Cr(VI) to Cr(III) by two biogenic magnetites and a synthetic magnetite was evaluated under batch and continuous flow conditions. Results indicate that nano-scale biogenic magnetite produced by incubating synthetic schwertmannite powder in cell suspensions of Geobacter sulfurreducens is more efficient at reducing Cr(VI) than either biogenic nano-magnetite produced from a suspension of ferrihydrite 'gel' or synthetic nano-scale Fe 3 O 4 powder. Although X-ray Photoelectron Spectroscopy (XPS) measurements obtained from post-exposure magnetite samples reveal that both Cr(III) and Cr(VI) are associated with nanoparticle surfaces, X-ray Magnetic Circular Dichroism (XMCD) studies indicate that some Cr(III) has replaced octahedrally coordinated Fe in the lattice of the magnetite. Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) measurements of total aqueous Cr in the associated solution phase indicated that, although the majority of Cr(III) was incorporated within or adsorbed to the magnetite samples, a proportion (∼10-15 %) was released back into solution. Studies of Tc(VII) uptake by magnetites produced via the different synthesis routes also revealed significant differences between them as regards effectiveness for remediation. In addition, column studies using a γ-camera to obtain real time images of a 99m Tc(VII) radiotracer were performed to visualize directly the relative performances of the magnetite sorbents against ultra-trace concentrations of metal oxyanion contaminants. Again, the magnetite produced from schwertmannite proved capable of retaining more (∼20%) 99m Tc(VII) than the magnetite produced from ferrihydrite, confirming that biomagnetite production for efficient environmental remediation can be fine-tuned through careful selection of the initial Fe(III) mineral substrate supplied to Fe

  20. The Connection between the Radio Jet and the γ-ray Emission in the Radio Galaxy 3C 120 and the Blazar CTA 102

    Directory of Open Access Journals (Sweden)

    Carolina Casadio

    2016-09-01

    Full Text Available We present multi-wavelength studies of the radio galaxy 3C 120 and the blazar CTA 102 during unprecedented γ-ray flares for both sources. In both studies the analysis of γ-ray data has been compared with a series of 43 GHz VLBA images from the VLBA-BU-BLAZAR program, providing the necessary spatial resolution to probe the parsec scale jet evolution during the high energy events. To extend the radio dataset for 3C 120 we also used 15 GHz VLBA data from the MOJAVE sample. These two objects which represent very different classes of AGN, have similar properties during the γ-ray events. The γ-ray flares are associated with the passage of a new superluminal component through the mm VLBI core, but not all ejections of new components lead to γ-ray events. In both sources γ-ray events occurred only when the new components are moving in a direction closer to our line of sight. We locate the γ-ray dissipation zone a short distance from the radio core but outside of the broad line region, suggesting synchrotron self-Compton scattering as the probable mechanism for the γ-ray production.

  1. In vitro effects of heparin and tissue factor pathway inhibitor on factor VII assays. possible implications for measurements in vivo after heparin therapy

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Larsen, L F; Ostergaard, P

    2000-01-01

    The coagulant activity of blood coagulation factor VII (FVII:C) can be lowered by changes in lifestyle and by therapeutic intervention, e.g. heparin infusion. The question is, however, whether FVII:C determined ex vivo is a valid measure of the FVII activity in vivo. We measured plasma FVII......:C, activated FVII (FVIIa), FVII protein (FVII:Ag), tissue factor pathway inhibitor (TFPI), triglycerides, and free fatty acids (FFA) before and 15 min after infusion of a bolus of unfractionated heparin (50 IU/kg body weight) in 12 healthy subjects. Additionally, we conducted in vitro experiments...... to investigate the effect of unfractionated heparin and TFPI, which is released from the endothelium by heparin, on FVII:C, FVIIa, and FVII:Ag. Heparin infusion decreased triglycerides and increased FFA and TFPI. This was accompanied by significant reductions in FVIIa, FVII:C and FVII:Ag. In vitro, anti...

  2. Pervivencia de los Tristia de Ovidio en la Antigüedad (ssI-VII)

    OpenAIRE

    Baeza Angulo, Eulogio

    1995-01-01

    El presente artículo persigue un doble objetivo. En primer lugar, mostrar en conjunto cuál ha sido la influencia y pervivencia de los Tristia de Ovidio hasta el siglo vii d. C. Y, en segundo lugar, que, aunque existen ciertos ecos de esta obra, sin embargo su pervivencia ha sido prácticamente testimonial frente a la gran influencia ejercida por las Metamorfosis y la obra elegíacoamatoria. The aim of this essay is a double one. First of alt, it is aimed at showing dic influen...

  3. Aspectos literarios de la obra de don Joan de Castellanos : Capítulo VII

    Directory of Open Access Journals (Sweden)

    Mario Germán Romero

    1966-02-01

    Full Text Available Capitulo VII. Los discursos de Colón Es sabido que los escritores antiguos; principalmente los historiógrafos, introducían supuestos discursos en sus obras. Salustio consigna cuatro en sus Historias. Tito Livio los elabora con perfección y los pone en boca de políticos y generales importantes; en los treinta y cinco libros que se conservan de este autor encontramos unos cuatrocientos discursos, breves o extensos, que como los de Salustio fueron recopilados y editados para fines retóricos.

  4. Current driven drift instability in the W VII-A stellarator

    International Nuclear Information System (INIS)

    Deutsch, R.; Wobig, H.

    1978-12-01

    The instability region and growth rates of current driven drift modes in the W VII-A stellarator are calculated. Several theoretical results are evaluated for specific temperature and density profiles. It is found that in the outer region of the plasma-column (r > 6 cm) collisional drift waves with wavelengths (k 2 x + K 2 y)sup(-1/2) = 0.13 - 0.3 cm exist. In this region also the electron thermal conductivity determined experimentally appears to be large. (orig./GG) [de

  5. Hormone therapy affects plasma measures of factor VII-activating protease in younger postmenopausal women

    DEFF Research Database (Denmark)

    Mathiasen, Jørn Sidelmann; Skouby, S.O.; Vitzthum, F.

    2010-01-01

    Objectives Current reviews indicate that hormone therapy (HT) has a protective role in coronary heart disease (CHD) in younger postmenopausal women, whereas HT contributes to CHD in older women Factor VII-activating protease (FSAP) is a serine protease that accumulates in unstable atherosclerotic...... for the determination of FSAP antigen and FSAP activity. Results The FSAP measures were comparable at baseline. No significant changes were observed in the control group after 12 months. HT in general induced a significant increase in FSAP antigen (7.7 mu g/ml at baseline and 8.0 mu g/ml after 12 months, p = 0...

  6. Vacuum magnetic field and modular coil system of the advanced stellarator Wendelstein VII-AS

    International Nuclear Information System (INIS)

    Rau, F.; Kisslinger, J.; Wobig, H.

    1982-06-01

    The vacuum field and the modular coils of the advanced stellarator WENDELSTEIN VII-AS are described. Each of the five field periods contains 9 different twisted coils, one of them with increased dimensions and current in order to provide sufficient access. The standard vacuum field configuration (B=3 T, t=0.39, aspect ratio approx. equal to 10, low shear, and magnetic well) can be varied by toroidal and vertical fields, or by changing independently the current in the large special coils. From a study of magnetic field perturbations some estimates are derived for the admissible coil tolerances. (orig.)

  7. Underground Test Area Subproject Phase I Data Analysis Task. Volume VII - Tritium Transport Model Documentation Package

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-12-01

    Volume VII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the tritium transport model documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  8. Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy.

    Science.gov (United States)

    Hu, Zhiwei; Cheng, Jijun; Xu, Jie; Ruf, Wolfram; Lockwood, Charles J

    2017-02-01

    Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls. We found that TF is specifically expressed on angiogenic VECs in a time-dependent manner in microvessels, venous and arterial vessels. TF-targeted therapeutic agents, including factor VII (fVII)-IgG1 Fc and fVII-conjugated photosensitizer, can selectively bind angiogenic VECs, but not the quiescent VECs. Moreover, fVII-targeted photodynamic therapy can selectively and completely eradicate angiogenic VECs. We conclude that TF is an angiogenic-specific receptor and the target molecule for fVII-targeted therapeutics. This study supports clinical trials of TF-targeted therapeutics for the treatment of angiogenesis-dependent diseases such as cancer, macular degeneration and endometriosis.

  9. Type VII and XVII Collagen mRNA Expressions in Regenerated Epidermal Laminae in Chronic Equine Laminitis

    Science.gov (United States)

    KUWANO, Atsutoshi; HASEGAWA, Telhisa; ARAI, Katsuhiko

    2009-01-01

    To confirm ability forming the basement membrane of the regenerated laminar epidermis (rLE) in chronic laminitis, expression of type VII and type XVII collagen mRNAs in the rLE was studied applying sequences of two type of murine collagens. On northern blot analysis, complement DNA (cDNA) probes adjusted from the murine type VII and type XVII collagen could hybridize with the equine mRNAs, and each signal was detected as single-bands at approximately 9.5 kb and 5.6 kb, respectively. Contrasting with the expression level of equine glyceraldehyde-3-phosphate dehydrogenease mRNA, the band of type VII collagen mRNA in laminitis was stronger than normal, but the type XVII collagen mRNA in laminitis was less than normal. By in situ hybridization, positive signals in response to the murine type VII and type XVII collagen mRNA probes could be detected in the equine laminitic rLE region. From these results, it is concluded that the keratinocytes constructing the rLE in chronic stage of laminitis can express type VII and type XVII collagen mRNAs and these expression patterns were different from the normal. PMID:24833961

  10. Komparasi Pemahaman Konsep Bangun Datar Siswa Antara Yang Diajar Dengan Model Pembelajaran Advance Organizer Dengan Peta Konsep Dan Model Pembelajaran Yang Mengadopsi Teori Van Hiele Pada Kelas VII SMPN 2 Sinjai Timur

    Directory of Open Access Journals (Sweden)

    Edi Syukri

    2016-02-01

    perbedaan pemahaman konsep bangun datar siswa antara yang diajar dengan model pembelajaran advance organizer dengan peta konsep dan model pembelajaran yag mengadopsi teori Van Hiele.Kata kunci: Pendekatan saintifik, Keterampilan proses sains, Hasil belajar kognitif biologi. ABSTRACTThe type of this research is experimental research that aims to: (1 know the learning outcomes, activities, and responses of students to advance organizer learning model with concept maps and learning models that adopt Van Hiele theory on the subject of wake up, especially quadrilateral class VII SMPN 2 Sinjai East, (2 to know how to understand the concept of students' wake up between those taught by advance organizer learning model with concept map and learning model adopting Van Hiele theory. The population in this study were all students of class VII of SMPN 2 Sinjai Timur and the sample consisted of two classes namely class VII-A and class VII-C, both as an experimental class was selected using purposive random sampling technique. The data collected consisted of data on student learning outcomes, student activity data in learning, and student response data on the device and learning. The results showed that the score of students' mathematics learning outcomes in experimental class 1 with mean of 20,36 and standard deviation 2,164 reach classical completeness equal to 89,29%, and student activity in learning is in the active category and student response to device and its learning is positive. In general, it is concluded that advanced organizer learning model with concept map to be applied in class VII SMPN 2 Sinjai Timur with quite effective category. Score of student learning outcomes in experiment class 2 with mean of 20,63 and standard deviation 2,589 reach classical completeness equal to 88,89% and student activity in learning is inactive category and student response to device and its learning is positive. It is generally concluded that the learning model adopting Van Hiele's theory to

  11. Effect of octanols structure on their extraction ability as regards to rhenium(VII) in sulfuric acid solutions

    International Nuclear Information System (INIS)

    Kasikov, A.G.; Petrova, A.M.

    2007-01-01

    It is established that extraction ability of octanols as regards to rhenium(VII) and sulfuric acid depends on the structure of alcohol, but if in passage from octanol-1 to octanol-3 as regard to rhenium(VII) it rises, then for H 2 SO 4 it falls. Dependence of the distribution function of rhenium from the concentration of the acid has maximums at 4-7 mol l 1- that the most distinctly it becomes apparent for secondary alcohols. Decreasing the extraction ability of octyl alcohols with the growth of H 2 SO 4 concentration more than 7 mol l 1- is connected with the change of extractant composition and forms of rhenium(VII) being in the solution [ru

  12. Helical phase of chiral nematic liquid crystals as the Bianchi VII0 group manifold.

    Science.gov (United States)

    Gibbons, G W; Warnick, C M

    2011-09-01

    We show that the optical structure of the helical phase of a chiral nematic is naturally associated with the Bianchi VII(0) group manifold, of which we give a full account. The Joets-Ribotta metric governing propagation of the extraordinary rays is invariant under the simply transitive action of the universal cover E(2) of the three-dimensional Euclidean group of two dimensions. Thus extraordinary light rays are geodesics of a left-invariant metric on this Bianchi type VII(0) group. We are able to solve, by separation of variables, both the wave equation and the Hamilton-Jacobi equation for this metric. The former reduces to Mathieu's equation, and the latter to the quadrantal pendulum equation. We discuss Maxwell's equations for uniaxial optical materials where the configuration is invariant under a group action and develop a formalism to take advantage of these symmetries. The material is not assumed to be impedance matched, thus going beyond the usual scope of transformation optics. We show that for a chiral nematic in its helical phase Maxwell's equations reduce to a generalized Mathieu equation. Our results may also be relevant to helical phases of some magnetic materials and to light propagation in certain cosmological models.

  13. Y-12 Construction/Demolition Landfill VII: Permit application: Part 1 and 2

    International Nuclear Information System (INIS)

    1992-04-01

    The United States Department of Energy (DOE) has three major operating facilities on the DOE Oak Ridge Reservation (ORR) at Oak Ridge, Tennessee: the Y-12 Plant, the K-25 Site, and the Oak Ridge National Laboratory (ORNL). Operations associated with the DOE energy research and production facilities at Oak Ridge result in the production of several types of waste materials. Disposal of solid waste (as defined in the Solid Waste Processing and Disposal Rules for Tennessee) in disposal facilities operated by the Y-12 Plant is the responsibility of Y-12 Waste Management Division (MWD). The WMD is proposing to develop a facility that will include two new disposal units: one for construction/demolition waste and spoil and one for industrial solid waste. This manual describes the closure and post-closure plans for the construction/demolition waste and spoil disposal unit. This disposal unit is referred to as the Y-12 Construction/Demolition Landfill VII (CD-VII) and is to be operated by the Y-12 Plant for the DOE. This will be a Tennessee Department of Environment and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class IV disposal unit

  14. [Chemical tests with Marrubium species. Official data on Marubii herba in Pharmacopoeia Hungarica VII].

    Science.gov (United States)

    Telek, E; Tõth, L; Botz, L; Máthé, I

    1997-01-01

    About 40 species of the Marrubium genus (Lamiaceae) are known of which 2 species (M. vulgare L. and M. peregrinum L.) and one hybrid (M. x paniculatum Desr.) can be found as native plants in Hungary. The above-ground parts of M. vulgare L. are official in Hungarian Pharmacopoeia VII. Active substances in Marrubii herba are labdane-structured bitter materials. Although the presence of furanic labdane diterpenes in the plant is known, the pharmacopoeia gives only microscopic tests, qualitative tests (for other parts of the plant and foreign organic matter) for the bitter value of Marrubii herba. We have examined the main terpenoid substances isolated with column, gel and preparative layer chromatography. Structure elucidations were performed by means of UV, mass and NMR spectroscopy. We have compared the changes in terpenoid-type compounds (premarrubiin and marrubiin) in plants during the vegetation period; in different Marrubium species and in the different extractions of horehound by means of thin layer chromatography and densitometry. By reason of our results we propose qualitative and quantitative chemical tests for the paragraph of Marrubii herba in Pharmacopoeia Hungarica VII.

  15. Monte Carlo simulation of neutral beam injection in the Wendelstein VII-A stellarator

    International Nuclear Information System (INIS)

    Maassberg, H.

    1986-06-01

    Strong neutral beam heating in the W VII-A stellarator with injection nearly perpendicular to the magnetic field results in a high energy ion tail. In a simplified model, the full nonlinear Fokker-Planck equation based on Coulomb interactions is solved self-consistently by means of Monte Carlo techniques. Generalized scattering operators which are equivalent to the nonlinear Fokker-Planck collision term are derived. With the numerical simulation, the strong neutral beam heating is analyzed for a typical discharge in W VII-A with H 0 injection in a H + /D + plasma mixture for stationary conditions. Both deuterium and hydrogen distribution functions are calculated. The D + distribution is found to be highly isotropic, the deviation from a Maxwellian resulting mainly from electron cooling. Furthermore, ion heat conduction is of minor importance for the energy balance of the bulk part of the plasma. The H + distribution, however, develops a strong pressure anisotropy, which can also be deduced experimentally from the diamagnetic signal. (orig.)

  16. Determining the Oral Health Status of Disabled Patients of the Area VII in Cienfuegos

    Directory of Open Access Journals (Sweden)

    Ana Belkys Hernández Millán

    2014-10-01

    Full Text Available Background: disability is a social concern; however, there are few studies on the oral health status of disabled patients. Objective: to determine the oral health status of disabled patients of the Area VII in Cienfuegos province. Methods: a case series study was conducted in the Area VII of the municipality of Cienfuegos from January through December 2013. A total of 192 disabled patients who attended the dental clinic or received home visits were included. The variables analyzed were: age, sex, educational level, type of disability, epidemiological classification by oral health status, systemic diseases, risk factors for oral diseases, oral health, periodontal disease (gingivitis, periodontitis, malocclusions, premalignant lesions, need for total or partial denture and need for treatment in primary or secondary care. The information was collected from the medical records and the disability rating sheets. Results are expressed as numbers and percentages. Results: women and patients aged 35-59 years were the most affected. Chronic degenerative diseases predominated, as well as patients in the epidemiological classification by oral health status and hypertension among systemic diseases. Having a history of cavities was the most significant risk factor; chronic edematous gingivitis was the most common, with a higher percentage. Conclusions: the oral health in the study group was poor and it is difficult for the Comprehensive General Dentist to treat these patients despite the existence of care programs for the disabled.

  17. Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.

    Science.gov (United States)

    Altug, Cevher; Güneş, Hanife; Nocentini, Alessio; Monti, Simona Maria; Buonanno, Martina; Supuran, Claudiu T

    2017-02-15

    Two series of benzenesulfonamide containing isoxazole compounds were prepared by using conventional and microwave (MW) methods. 5-Amino-3-aryl-N-(4-sulfamoylphenyl)isoxazole-4-carboxamide derivatives were synthesized by the reaction of hydroxymoyl chlorides with 2-cyano-N-(4-sulfamoylphenyl)acetamide in the presence of triethylamine. The synthesized 5-amino isoxazoles were reacted with various benzoyl chlorides in order to obtain 5-amidoisoxazoles. The novel compounds were screened in vitro as inhibitors of four human (h) isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1): hCA I, hCA II, hCA IV and hCA VII. The derivatives of the first series were shown to possess excellent inhibitory activity against the cytosolic isoform hCA II, an antiglaucoma drug target, with K I s in the range of 0.5-49.3nM and hCA VII, a recently validated anti-neuropathic pain target with K I s in the range of 4.3-51.9nM. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. A Shigella boydii bacteriophage which resembles Salmonella phage ViI

    Directory of Open Access Journals (Sweden)

    She Yi-Min

    2011-05-01

    Full Text Available Abstract Background Lytic bacteriophages have been applied successfully to control the growth of various foodborne pathogens. Sequencing of their genomes is considered as an important preliminary step to ensure their safety prior to food applications. Results The lytic bacteriophage, ΦSboM-AG3, targets the important foodborne pathogen, Shigella. It is morphologically similar to phage ViI of Salmonella enterica serovar Typhi and a series of phages of Acinetobacter calcoaceticus and Rhizobium meliloti. The complete genome of ΦSboM-AG3 was determined to be 158 kb and was terminally redundant and circularly permuted. Two hundred and sixteen open reading frames (ORFs were identified and annotated, most of which displayed homology to proteins of Salmonella phage ViI. The genome also included four genes specifying tRNAs. Conclusions This is the first time that a Vi-specific phage for Shigella has been described. There is no evidence for the presence of virulence and lysogeny-associated genes. In conclusion, the genome analysis of ΦSboM-AG3 indicates that this phage can be safely used for biocontrol purposes.

  19. Helical phase of chiral nematic liquid crystals as the Bianchi VII0 group manifold

    Science.gov (United States)

    Gibbons, G. W.; Warnick, C. M.

    2011-09-01

    We show that the optical structure of the helical phase of a chiral nematic is naturally associated with the Bianchi VII0 group manifold, of which we give a full account. The Joets-Ribotta metric governing propagation of the extraordinary rays is invariant under the simply transitive action of the universal cover Ẽ(2) of the three-dimensional Euclidean group of two dimensions. Thus extraordinary light rays are geodesics of a left-invariant metric on this Bianchi type VII0 group. We are able to solve, by separation of variables, both the wave equation and the Hamilton-Jacobi equation for this metric. The former reduces to Mathieu’s equation, and the latter to the quadrantal pendulum equation. We discuss Maxwell’s equations for uniaxial optical materials where the configuration is invariant under a group action and develop a formalism to take advantage of these symmetries. The material is not assumed to be impedance matched, thus going beyond the usual scope of transformation optics. We show that for a chiral nematic in its helical phase Maxwell’s equations reduce to a generalized Mathieu equation. Our results may also be relevant to helical phases of some magnetic materials and to light propagation in certain cosmological models.

  20. Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation

    International Nuclear Information System (INIS)

    O'Hara, P.J.; Grant, F.J.; Haldeman, B.A.; Gray, C.L.; Insley, M.Y.; Hagen, F.S.; Murray, M.J.

    1987-01-01

    Activated factor VII (factor VIIa) is a vitamin K-dependent plasma serine protease that participates in a cascade of reactions leading to the coagulation of blood. Two overlapping genomic clones containing sequences encoding human factor VII were isolated and characterized. The complete sequence of the gene was determined and found to span about 12.8 kilobases. The mRNA for factor VII as demonstrated by cDNA cloning is polyadenylylated at multiple sites but contains only one AAUAAA poly(A) signal sequence. The mRNA can undergo alternative splicing, forming one transcript containing eight segments as exons and another with an additional exon that encodes a larger prepro leader sequence. The latter transcript has no known counterpart in the other vitamin K-dependent proteins. The positions of the introns with respect to the amino acid sequence encoded by the eight essential exons of factor VII are the same as those present in factor IX, factor X, protein C, and the first three exons of prothrombin. These exons code for domains generally conserved among members of this gene family. The comparable introns in these genes, however, are dissimilar with respect to size and sequence, with the exception of intron C in factor VII and protein C. The gene for factor VII also contains five regions made up of tandem repeats of oligonucleotide monomer elements. More than a quarter of the intron sequences and more than a third of the 3' untranslated portion of the mRNA transcript consist of these minisatellite tandem repeats

  1. New Neutron, Proton, and S(α,β) MCNP Data Libraries Based on ENDF/B-VII

    International Nuclear Information System (INIS)

    Little, Robert C.; Trellue, Holly R.; MacFarlane, Robert E.; Kahler, A.C.; Lee, Mary Beth; White, Morgan C.

    2008-01-01

    The general-purpose Evaluated Nuclear Data File ENDF/B-VII.0 was released in December 2006. A number of sub-libraries were included in ENDF/B-VII.0 such that data were provided for incident neutrons, photons, and charged particles. This paper describes the creation of MCNP data libraries at Los Alamos National Laboratory based on three ENDF/B-VII.0 sub-libraries: neutrons, protons, and thermal scattering. An ACE-formatted continuous-energy neutron data library called ENDF70 for MCNP has been produced. This library provides data for 390 materials at five temperatures: 293.6, 600, 900, 1200, and 2500 K. The library was processed primarily with Version 248 of NJOY99. Extensive checking and quality-assurance tests were applied to the data. Improvements to the processing code were made and certain evaluations were modified as a result of these tests. ENDF/B-VII.0 included proton evaluations for 48 target materials. Forty-seven proton evaluations (all except for 13 C) were processed at room temperature and combined into the MCNP library ENDF70PROT. Neutron thermal S(α,β) scattering data exist for twenty different materials in ENDF/B-VII.0. All twenty of these evaluations were processed at all applicable temperatures (these vary for each evaluation), and combined into the MCNP library ENDF70SAB. All of these ENDF/B-VII.0 based MCNP libraries (ENDF70, ENDF70PROT, and ENDF70SAB) are available as part of the MCNP5 1.50 release. (authors)

  2. Genes VI, VII, and IX of phage M13 code for minor capsid proteins of the virion.

    OpenAIRE

    Simons, G F; Konings, R N; Schoenmakers, J G

    1981-01-01

    The minor capsid proteins C and D from phage M13 have been characterized by differential amino acid labeling and amino-terminal sequence analysis. We demonstrate that D protein (Mr 12,260) is the product of gene VI, whereas the C component is composed of the products of both gene VII (Mr 3580) and gene IX (Mr 3650). Our data further show that the proteins of genes VI, VII, and IX are not subject to proteolytic processing but are packaged into mature virions as their primary translational prod...

  3. Long-Term and Rapid Radio Variability of the Blazar 3C 454.3 in 2010-2017

    Science.gov (United States)

    Gorshkov, A. G.; Ipatov, A. V.; Ipatova, I. A.; Konnikova, V. K.; Mardyshkin, V. V.; Mingaliev, M. G.; Kharinov, M. A.

    2018-03-01

    The article presents the results of observations of the blazar 3C 454.3 (J2253+1608), obtained in 2010-2017 on the RATAN-600 radio telescope of the Special Astrophysical Observatory at 4.6, 8.2, 11.2, and 21.7 GHz and on the 32-m Zelenchuk and Badary radio telescopes of the Quasar VLBI Network of the Institute of Applied Astronomy at 4.84 and 8.57 GHz. Long-term variability of the radio emission is studied, as well as variability on time scales of several days and intraday variability (IDV). Two flares were observed in the long-term light curve, in 2010 and in 2015-2017. The flux density at 21.7 GHz increased by a factor of ten during these flares. The delay in the maximum of the first flare at 4.85 GHz relative to the maximum at 21.7 GHz was six months. The time scale for variability on the descending branch of the first flare at 21.7 GHz was τvar = 1.2 yrs, yielding an upper limit on the linear size of the emitting region of 0.4 pc, corresponding to an angular size of 0.06 mas. The brightness temperature during the flare exceeded the Compton limit, implying a Doppler factor δ = 3.5, consistent with the known presence of a relativistic jet oriented close to the line of sight. No significant variability on time scales from several days to several weeks was found in five sets of daily observations carried out over 120 days. IDV was detected at 8.57 GHz on the 32-m telescopes in 30 of 61 successful observing sessions, with the presence of IDV correlated with the maxima of flares. The characteristic time scale for the IDV was from two to ten hours. A number of IDV light curves show the presence of a time delay in the maxima in the light curves for simultaneous observations carried out on the Badary and Zelenchuk antennas, which are widely separated in longitude. This demonstrates that the IDV most like arises in the interstellar medium.

  4. Federal Sector Labor-Management Relations: A Guide to Decisional Materials Relating to Title VII of the Civil Service Reform Act of 1978.

    Science.gov (United States)

    Wilson, Karen A.

    1984-01-01

    Provides overview of federal agencies administering Title VII of Civil Service Reform Act (1978) and a 22-item annotated bibliography of selected federal and commercial publications on decisional materials relating to Title VII. Sources for administrative agency rulings and arbitration awards, citators, digests, indexes, online databases, and…

  5. Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

    DEFF Research Database (Denmark)

    Holst, B; Elling, C E; Schwartz, T W

    2000-01-01

    -ion site located between AspIII:08-or a His residue introduced at this position in transmembrane domain (TM)-III-and a Cys residue substituted for AsnVII:06 in TM-VII. Here, this interhelical, bidentate metal-ion site is without loss of Zn(2+) affinity transferred to the tachykinin NK(1) receptor...

  6. Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

    NARCIS (Netherlands)

    Kneuper, Holger; Cao, Zhen Ping; Twomey, Kate B; Zoltner, Martin; Jäger, Franziska; Cargill, James S; Chalmers, James; van der Kooi - Pol, Magda; van Dijl, Jan Maarten; Ryan, Robert P; Hunter, William N; Palmer, Tracy

    The Type VII protein secretion system, found in Gram-positive bacteria, secretes small proteins, containing a conserved W-x-G amino acid sequence motif, to the growth medium. Staphylococcus aureus has a conserved Type VII secretion system, termed Ess, which is dispensable for laboratory growth but

  7. Impaired secretion of carboxyl-terminal truncated factor VII due to an F7 nonsense mutation associated with FVII deficiency.

    Science.gov (United States)

    Tanaka, Ryoko; Nakashima, Daisuke; Suzuki, Atsuo; Miyawaki, Yuhri; Fujimori, Yuta; Yamada, Takayuki; Takagi, Akira; Murate, Takashi; Yamamoto, Koji; Katsumi, Akira; Matsushita, Tadashi; Naoe, Tomoki; Kojima, Tetsuhito

    2010-03-01

    Factor VII (FVII) is a vitamin K-dependent glycoprotein secreted into the blood circulation from hepatic cells. We investigated the molecular basis of the congenital FVII deficiency found in a Japanese patient. We analyzed the F7 gene of the patient, who was diagnosed with a FVII deficiency at pregnancy. We expressed a carboxyl-terminal truncated FVII (Arg462X FVII) corresponding to the identified mutation in CHO-K1 cells. To study roles of the carboxyl-terminus in the secretion of FVII, we also expressed a series of recombinant FVIIs deleted of limited numbers of carboxyl-terminal amino acids (462Arg-466Pro). We identified a nonsense mutation (c.1384C>T: p.Arg462X) in F7, leading to a lack of five amino acids in the carboxyl-terminus. In expression experiments, Arg462X FVII was undetectable not only by Western blotting, but also by ELISA. A Western blot analysis of the truncated FVIIs revealed that all mutants were expressed in the cells the same as the wild type, but were secreted into the culture medium in lesser amounts than the wild type depending on the length of the deletion, which was confirmed by ELISA. Arg462X FVII did not colocalize with the Golgi on immunofluorescence staining, suggesting that it might be retained in the ER and degraded in the cell. The carboxyl-terminal amino acids of FVII play an important role in its secretion, and the p.Arg462X mutation was likely to have caused the FVII deficiency in this patient. (c) 2009 Elsevier Ltd. All rights reserved.

  8. Comparison with adsorption of Re (VII) by two different γ-radiation synthesized silica-grafting of vinylimidazole/4-vinylpyridine adsorbents.

    Science.gov (United States)

    Xiao, Pu; Han, Dong; Zhai, Maolin; Xu, Ling; Li, Huibo

    2017-02-15

    Two silica gel based adsorbents for Re (VII), i.e. SS-MPTS-VIMH and SS-MPTS-VPQ, were synthesised. Silica gel was used as the matrix for γ-radiation grafting, and the monomer of 1-vinyl imidazole (VIM) and 4-vinylpyridine (4-VP) was grafted onto the silica silanized by methacryloxy propyl trimethoxyl silane, respectively. A VIM concentration of 2molL -1 and an absorbed dose of 30kGy were the optimal grafting conditions for adsorbent SS-MPTS-VIM, and a 4-VP concentration of 4molL -1 and an absorbed dose of 40kGy were the optimal grafting conditions for adsorbent SS-MPTS-VP. At the certain condition, the grafting yield of SS-MPTS-VIM was 30.1% and that of SS-MPTS-VP was 21.0%. The adsorption capacity of adsorbent SS-MPTS-VIMH was 145.99mgg -1 and that of SS-MPTS-VPQ was 71.08mgg -1 according to the Langmuir model. The adsorbent SS-MPTS-VPQ had better adsorption properties of acid resistance and anti-interference than SS-MPTS-VIMH. Dynamic column experiments showed that protonated adsorbent SS-MTPS-VIMH could be recycled with good performance while quaternized adsorbent SS-MPTS-VPQ could not. The adsorbent SS-MPTS-VIMH belongs to weak anion exchange adsorbent and SS-MPTS-VPQ belongs to strong anion exchange adsorbent. This study paves a way to the synthesis and application of a novel silica base adsorbents for Re (VII). Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Platão e a educação: um estudo do livro VII de “A República”/Plato and the education: a study of book VII of "The Republic"

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Lazarini

    2007-01-01

    Full Text Available LAZARINI, Ana Lúcia. Platão e a educação: um estudo do livro VII de “A República”. 89fl. 2007. Dissertação (Mestrado em Educação – Faculdade de Educação, Universidade Estadual de Campinas, Campinas. 2007.

  10. Atomic Structures of Minor Proteins VI and VII in the Human Adenovirus.

    Science.gov (United States)

    Dai, Xinghong; Wu, Lily; Sun, Ren; Zhou, Z Hong

    2017-10-04

    Human adenoviruses (Ad) are dsDNA viruses associated with infectious diseases, yet better known as tools for gene delivery and oncolytic anti-cancer therapy. Atomic structures of Ad provide the basis for the development of antivirals and for engineering efforts towards more effective applications. Since 2010, atomic models of human Ad5 have been independently derived from photographic film cryoEM and X-ray crystallography, but discrepancies exist concerning the assignment of cement proteins IIIa, VIII and IX. To clarify these discrepancies, here we have employed the technology of direct electron-counting to obtain a cryoEM structure of human Ad5 at 3.2 Å resolution. Our improved structure unambiguously confirmed our previous cryoEM models of proteins IIIa, VIII and IX and explained the likely cause of conflict in the crystallography models. The improved structure also allows the identification of three new components in the cavities of hexons - the cleaved N-terminus of precursor protein VI (pVIn), the cleaved N-terminus of precursor protein VII (pVIIn2), and mature protein VI. The binding of pVIIn2--by extension that of genome-condensing pVII--to hexons is consistent with the previously proposed dsDNA genome-capsid co-assembly for adenoviruses, which resembles that of ssRNA viruses but differs from the well-established mechanism of pumping dsDNA into a preformed protein capsid, as exemplified by tailed bacteriophages and herpesviruses. IMPORTANCE Adenovirus is a double-edged sword to humans - as a widespread pathogen and a bioengineering tool for anti-cancer and gene therapy. Atomic structure of the virus provides the basis for antiviral and application developments, but conflicting atomic models from conventional/film cryoEM and X-ray crystallography for important cement proteins IIIa, VIII, and IX have caused confusion. Using the cutting-edge cryoEM technology with electron counting, we improved the structure of human adenovirus type 5 and confirmed our

  11. A case presenting concurrence of Marfan syndrome, Basedow's disease and Arg353Gln polymorphism-related factor VII deficiency.

    Science.gov (United States)

    Tanaka, Kotoko; Seino, Yoshihiko; Inokuchi, Koiti; Ohmura, Kazuko; Kobayashi, Yoshinori; Takano, Teruo

    2005-02-15

    We report the case of a 48-year-old Japanese man who suffered from Marfan syndrome with severe aortic regurgitation, mitral regurgitation and rapid atrial fibrillation, which were aggravated by hyperdynamic circulatory conditions associated with coexistent Basedow's disease. Furthermore, concurrence of Arg353Gln polymorphism-related factor VII deficiency was discovered at the preoperative assessments. Both of his two brothers suffered from Marfan syndrome; however they had no findings of Arg353Glu polymorphism-related factor VII deficiency or Basedow's disease. After normalization of thyroid function, he had successfully the operations of Bentall procedure: a composite prosthetic graft: replacement of both the ascending aorta and aortic valve, and mitral valve annuloplasty. No specific therapy such as fresh frozen plasma or factor VII replacement therapy was required. He completely returned to his business work 6 weeks after the operation. Concurrence of Marfan syndrome and factor VII deficiency induced by two-hit genomic abnormalities and furthermore Basedow's disease, which significantly compromised the pathophysiological condition of Marfan syndrome, is extremely rare.

  12. The protein concentration of blood coagulation factor VII can be measured equally well in plasma and serum

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Overgaard, K; Gram, J

    1995-01-01

    In the Northwick Park Heart Study, the coagulant activity of factor VII (FVII:C) has been identified as a risk marker of ischaemic heart disease. In the fasting state, the protein concentration of FVII (FVII:Ag) might be an even better risk marker, because of the low coefficient of variation...

  13. Marine Mammals, Coastal and River Issues. Alaska Sea Week Curriculum Series VII. Alaska Sea Grant Report 84-8.

    Science.gov (United States)

    Mickelson, Belle

    This curriculum guide is the last (Series VII) in a six-volume set that comprises the Sea Week Curriculum Series developed in Alaska. The guide lends itself to the sixth-grade curriculum but can be adapted to preschool, secondary, and adult education. Eight units contain 43 activities with worksheets that cover the following topics: (1) the values…

  14. 2-year outcome after biodegradable polymer sirolimus- and biolimus- eluting coronary stents.From the randomized SORT OUT VII trial

    DEFF Research Database (Denmark)

    Jensen, Lisette Okkels; Maeng, Michael; Raungaard, Bent

    2018-01-01

    AIMS: The SORT OUT VII trial compared the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent with a slow polymer degradation and the thicker-strut stainless steel biolimus-eluting Nobori stent with a moderate-term polymer degradation in an all-comer patient population. METHODS AND RESULTS...

  15. 34 CFR 364.2 - What is the purpose of the programs authorized by chapter 1 of title VII?

    Science.gov (United States)

    2010-07-01

    ... chapter 1 of title VII? 364.2 Section 364.2 Education Regulations of the Offices of the Department of... INDEPENDENT LIVING SERVICES PROGRAM AND CENTERS FOR INDEPENDENT LIVING PROGRAM: GENERAL PROVISIONS General... independent living (IL), including a philosophy of consumer control, peer support, self-help, self...

  16. Title VII Enhancement Project for Compartiendo Culturas/Sharing Cultures 1995-96. Research Report on Educational Programs.

    Science.gov (United States)

    Houston Independent School District, TX. Dept. of Research and Evaluation.

    Compartiendo Culturas/Sharing Cultures, a Title VII Two-Way Developmental Bilingual Education Program at the Gary L. Herod Elementary School in the Houston Independent School District (Texas) was designed to end the isolation typically experienced by language minority students in traditional bilingual education and to provide language majority…

  17. 29 CFR 1620.27 - Relationship to the Equal Pay Act of title VII of the Civil Rights Act.

    Science.gov (United States)

    2010-07-01

    ... established upon a showing that an employer pays different wages to employees of opposite sexes for equal work... higher pay for equal work. ... 29 Labor 4 2010-07-01 2010-07-01 false Relationship to the Equal Pay Act of title VII of the Civil...

  18. 75 FR 36099 - Legislative Changes to Primary Care Loan Program Authorized Under Title VII of the Public Health...

    Science.gov (United States)

    2010-06-24

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Legislative Changes to Primary Care Loan Program Authorized Under Title VII of the Public Health Service Act AGENCY... changes Section 723 of the Public Health Service Act (PHSA) regarding administration of the PCL program...

  19. Redwood City School District ESEA Title VII Bilingual Project LEARN. 1981-1982 Annual and Longitudinal Report.

    Science.gov (United States)

    Jones, Earl; Jones, Eleanor

    The Redwood City School District Elementary Secondary Education Act (ESEA) Title VII Bilingual Education Program offered instruction in English and Spanish through an integrated approach, to take advantage of students' strengths and help them progress as rapidly as possible in concept development while they acquire English proficiency. The limited…

  20. 78 FR 36711 - Food and Drug Administration Safety and Innovation Act Title VII-Drug Supply Chain; Standards for...

    Science.gov (United States)

    2013-06-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Chapter I [Docket Nos. FDA-2013-N-0683, FDA-2013-N-0684, and FDA-2013-N-0685] Food and Drug Administration Safety and Innovation Act Title VII--Drug Supply Chain; Standards for Admission of Imported Drugs, Registration of...

  1. LAWS ON SEX DISCRIMINATION IN EMPLOYMENT--FEDERAL CIVIL RIGHTS ACT, TITLE VII. STATE FAIR EMPLOYMENT PRACTICES LAWS.

    Science.gov (United States)

    Women's Bureau (DOL), Washington, DC.

    TITLE VII OF THE FEDERAL CIVIL RIGHTS ACT (1964) PROHIBITS DISCRIMINATION ON THE BASIS OF SEX IN ADDITION TO THE USUAL GROUNDS OF RACE, COLOR, RELIGION, AND NATIONAL ORIGIN. IT COVERS PRIVATE EMPLOYMENT AND LABOR ORGANIZATIONS ENGAGED IN INDUSTRIES AFFECTING COMMERCE, AS WELL AS EMPLOYMENT AGENCIES. IT IS UNLAWFUL FOR EMPLOYERS TO REFUSE TO HIRE,…

  2. Very Rapid High-amplitude Gamma-Ray Variability in Luminous Blazar PKS 1510-089 Studied with Fermi-LAT

    Energy Technology Data Exchange (ETDEWEB)

    Saito, S.; Stawarz, L.; Tanaka, Y.T.; Takahashi, T.; Madejski, G.; D' Ammando, F.

    2013-03-20

    Here we report on the detailed analysis of the γ-ray light curve of a luminous blazar PKS 1510-089 observed in the GeV range with the Large Area Telescope (LAT) onboard the Fermi satellite during the period 2011 September - December. By investigating the properties of the detected three major flares with the shortest possible time binning allowed by the photon statistics, we find a variety of temporal characteristics and variability patterns. This includes a clearly asymmetric profile (with a faster flux rise and a slower decay) of the flare resolved on sub-daily timescales, a superposition of many short uncorrelated flaring events forming the apparently coherent longer-duration outburst, and a huge single isolated outburst unresolved down to the timescale of three-hours. In the latter case we estimate the corresponding γ-ray flux doubling timescale to be below one hour, which is extreme and never previously reported for any active galaxy

  3. The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus.

    Science.gov (United States)

    Soria, Jose Manuel; Almasy, Laura; Souto, Juan Carlos; Sabater-Lleal, Maria; Fontcuberta, Jordi; Blangero, John

    2005-10-01

    Localization of human quantitative trait loci (QTLs) is now routine. However, identifying their functional DNA variants is still a formidable challenge. We present a complete dissection of a human QTL using novel statistical techniques to infer the most likely functional polymorphisms of a QTL that influence plasma levels of clotting factor VII (FVII), a risk factor for cardiovascular disease. Resequencing of 15 kb in and around the F7 gene identified 49 polymorphisms, which were then genotyped in 398 people. Using a Bayesian quantitative trait nucleotide (BQTN) method, we identified four to seven functional variants that completely account for this QTL. These variants include both rare coding variants and more common, potentially regulatory polymorphisms in intronic and promoter regions.

  4. A ¤high-fat meal does not activate blood coagulation factor vii in minipigs

    DEFF Research Database (Denmark)

    Olsen, A. K.; Larsen, L. F.; Bladbjerg, E.-M.

    2001-01-01

    tool. We studied postprandial FVII activation in seven non-fasting Göttingen minipigs. Intralipid (4 g/kg) was administered through a gastric tube in two fractions at 9.00 a.m. (one-third of total dose) and 10.30 a.m. (two-thirds of total dose). Blood samples were drawn 0.5 h before (baseline) and 2, 3......It is a matter of debate whether postprandial activation of blood coagulation factor VII (FVII) is associated with an increased risk of thrombosis. To clarify this question, an animal model in which consequences of dietary FVII activation can be studied in a more detailed way would be an important...... to activate blood coagulation FVII in minipigs, the pig is apparently not a relevant model for the study of dietary FVII activation and thrombin generation. Udgivelsesdato: 2001-Mar...

  5. Spectrum and energy levels of six-times ionized yttrium (Y VII)

    Science.gov (United States)

    Reader, Joseph

    2018-03-01

    The spectrum of six-times ionized yttrium, Y VII, was photographed with a sliding-spark discharge on 10.7 m normal- and grazing-incidence spectrographs. The region of observation was 157-824 Å. The observations extend the known configurations 4s24p3, 4s4p4, 4p5, 4s24p25s, 4s24p26s to the nearly complete 4s24p24d configuration. Our results for 4s24p24d significantly revise results of Rahimullah et al (1978 Phys. Scr. 18 96); Ateqad et al (1984 J. Phys. B: At. Mol. Phys. 17 4617). A total of 168 lines and 56 energy levels are now known for this ion. The observed configurations were interpreted with Hartree-Fock calculations and least-squares fits of the energy parameters to the observed levels. Transition probabilities for all classified lines were calculated with the fitted parameters.

  6. Una lista de autores literarios en Plinio el Viejo: Naturalis Historia VII 107-117

    Directory of Open Access Journals (Sweden)

    Susana González Marín

    2003-06-01

    Full Text Available In NH VII 107-117 the Elder Pliny offers a selection of Greek and Roman notabilities who achieved prominence through their ingenium. This selection follows the model set by περὶ τεχνιτῶν treatises, especially Varro's De Poetis. Pliny's selection is based on two considerations: the glory achieved by each person; the opinions expressed by an authority, in most cases a politician. According to Pliny, the four Roman authors selected (Ennius, Virgil, Varro, Cicero served as paragons of excellence for the Roman people. Through his selection, Pliny defines his own attitude about the literary tradition and the intellectual elite in Rome: his idea of literature as a public service, the practical value of his work, his preference for prose and the increasingly strong influence exerted by experts on Roman Society.

  7. A high-fat meal does not activate blood coagulation factor VII in minipigs

    DEFF Research Database (Denmark)

    Olsen, A K; Larsen, L F; Bladbjerg, E-M

    2001-01-01

    It is a matter of debate whether postprandial activation of blood coagulation factor VII (FVII) is associated with an increased risk of thrombosis. To clarify this question, an animal model in which consequences of dietary FVII activation can be studied in a more detailed way would be an important...... tool. We studied postprandial FVII activation in seven non-fasting Göttingen minipigs. Intralipid (4 g/kg) was administered through a gastric tube in two fractions at 9.00 a.m. (one-third of total dose) and 10.30 a.m. (two-thirds of total dose). Blood samples were drawn 0.5 h before (baseline) and 2, 3....../l (baseline) to 2.56 mmol/l 5 h postprandially (P meal does not seem...

  8. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage

    DEFF Research Database (Denmark)

    Mayer, Stephan A; Brun, Nikolai C; Begtrup, Kamilla

    2008-01-01

    BACKGROUND: Intracerebral hemorrhage is the least treatable form of stroke. We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes. METHODS: We randomly assigned 841...... patients with intracerebral hemorrhage to receive placebo (268 patients), 20 microg of rFVIIa per kilogram of body weight (276 patients), or 80 microg of rFVIIa per kilogram (297 patients) within 4 hours after the onset of stroke. The primary end point was poor outcome, defined as severe disability...... or death according to the modified Rankin scale 90 days after the stroke. RESULTS: Treatment with 80 microg of rFVIIa per kilogram resulted in a significant reduction in growth in volume of the hemorrhage. The mean estimated increase in volume of the intracerebral hemorrhage at 24 hours was 26...

  9. Henry VII and Lombard cities (1311, between political flexibility and authority: preliminary notes

    Directory of Open Access Journals (Sweden)

    Federica Cengarle

    2014-04-01

    Full Text Available During his first months in Italy Henry VII acts now as rex pacificus, chosen by the communities as peace’s guarantor, now as emperor-judge, fully conscious of being selected from God’s will, now as a compliant politician, now as an authoritarian rights’ holder, now as a merciful ruler, now as an inflexible one. He adjusts to different city interlocutors and contexts two unlike and opposite sovereignty’s concepts, which are the outcome at times of a local collective will, at times of an unquestionable universal authority. This behaviour proves his political realism beyond his need to protect the Empire’s “symbolic capital”.

  10. Benchmarking Atomic Data for Astrophysics: Be-like Ions between B II and Ne VII

    Science.gov (United States)

    Wang, Kai; Chen, Zhan Bin; Zhang, Chun Yu; Si, Ran; Jönsson, Per; Hartman, Henrik; Gu, Ming Feng; Chen, Chong Yang; Yan, Jun

    2018-02-01

    Large-scale self-consistent multiconfiguration Dirac–Hartree–Fock and relativistic configuration interaction calculations are reported for the n≤slant 6 levels in Be-like ions from B II to Ne VII. Effects from electron correlation are taken into account by means of large expansions in terms of a basis of configuration state functions, and a complete and accurate data set of excitation energies; lifetimes; wavelengths; electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole line strengths; transition rates; and oscillator strengths for these levels is provided for each ion. Comparisons are made with available experimental and theoretical results. The uncertainty of excitation energies is assessed to be 0.01% on average, which makes it possible to find and rule out misidentifications and aid new line identifications involving high-lying levels in astrophysical spectra. The complete data set is also useful for modeling and diagnosing astrophysical plasmas.

  11. Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).

    Science.gov (United States)

    Subramaniam, Saravanan; Thielmann, Ina; Morowski, Martina; Pragst, Ingo; Sandset, Per Morten; Nieswandt, Bernhard; Etscheid, Michael; Kanse, Sandip M

    2015-04-01

    Factor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis. Genetic epidemiological studies have implied a role for FSAP in carotid stenosis, stroke and thrombosis. To date, no in vivo evidence is available to support these claims. We have, for the first time, used FSAP-/- mice to define its role in thrombosis and haemostasis in vivo and to characterise the molecular mechanisms involved. FeCl3-induced arterial thrombosis in carotid and mesenteric artery revealed that the occlusion time was significantly increased in FSAP-/- mice (pendogenous FSAP impaired the formation of stable, occlusive thrombi in mice. The underlying in vivo effect of FSAP is more likely to be related to the modulation of TFPI rather than FVIIa.

  12. La CIDIP-VII y la defensa del consumidor americano. Aportes desde la experiencia del MERCOSUR

    Directory of Open Access Journals (Sweden)

    Cristian Ricardo A. Piris

    2014-03-01

    Full Text Available En el presente artículo se aborda la situación del consumidor ante la expansión de los mercados y por ende del consumo, junto con las consecuencias que trae aparejadas esta situación. En ese contexto, se lleva a cabo un análisis de la normativa que podría llegar a ser aplicable en cada ocasión en la que haga falta regular alguna conducta o situación determinada en el continente Americano. Luego, se hace hincapié en la CIDIP VII, siendo que constituye un componente principal de la OEA en el desarrollo del Derecho Internacional Privado en América y cumple un papel muy importante en la codificación y armonización de este derecho en la región.

  13. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

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    Vaida Morkūnaitė

    2014-01-01

    Full Text Available A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA and isothermal titration calorimetry (ITC. Saccharin bound the CAs weakly, exhibiting the affinities of 1–10 mM for four CAs except CA I where binding could not be detected. Several sulfonamide-bearing saccharines exhibited strong affinities of 1–10 nM towards particular CA isoforms. The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs.

  14. VII Seminario Internacional de Investigación en Odontología

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    Carolina Torres Rodríguez

    2016-07-01

    Full Text Available El VII Seminario de investigación en odontología, organizado por el programa de Maestría en Odontología, es un espacio de encuentro de estudiantes, investigadores nacionales e internacionales y asistentes, con el fin de compartir conocimientos y entablar redes de colaboración. También es una estrategia de comunicación, difusión, apropiación y transferencia de conocimiento y de los resultados de la investigación de los diferentes grupos con la comunidad científica nacional y/o internacional y un método para dar a conocer, promover e impulsar la investigación a nivel nacional, todo esto con el fin de brindar soluciones a las diferentes problemáticas de la profesión y de la salud oral y general.

  15. Comprehensive monitoring of gamma-ray bright blazars. I. Statistical study of optical, X-ray, and gamma-ray spectral slopes

    Energy Technology Data Exchange (ETDEWEB)

    Williamson, Karen E.; Jorstad, Svetlana G.; Marscher, Alan P.; Agudo, Iván; Joshi, Manasvita; Malmrose, Michael P. [Institute for Astrophysical Research, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Larionov, Valeri M.; Blinov, Dmitry A.; Efimova, Natalia V.; Hagen-Thorn, Vladimir A.; Konstantinova, Tatiana S.; Kopatskaya, Evgenia N.; Larionova, Elena G.; Larionova, Liudmilla V. [Astronomical Institute, St. Petersburg State University, Universitetskij Pr. 28, Petrodvorets, 198504 St. Petersburg (Russian Federation); Smith, Paul S. [Steward Observatory, University of Arizona, Tucson, AZ 85721-0065 (United States); Arkharov, Arkady A. [Main (Pulkovo) Astronomical Observatory of RAS, Pulkovskoye shosse 60, 196140 St. Petersburg (Russian Federation); Casadio, Carolina; Gómez, José L.; Molina, Sol N. [Instituto de Astrofísica de Andalucía, CSIC, Apartado 3004, E-18080 Granada (Spain); McHardy, Ian M., E-mail: kwilliam@bu.edu [Department of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom); and others

    2014-07-10

    We present γ-ray, X-ray, ultraviolet, optical, and near-infrared light curves of 33 γ-ray bright blazars over 4 years that we have been monitoring since 2008 August with multiple optical, ground-based telescopes and the Swift satellite, and augmented by data from the Fermi Gamma-ray Space Telescope and other publicly available data from Swift. The sample consists of 21 flat-spectrum radio quasars (FSRQs) and 12 BL Lac objects (BL Lacs). We identify quiescent and active states of the sources based on their γ-ray behavior. We derive γ-ray, X-ray, and optical spectral indices, α{sub γ}, α{sub X}, and α{sub o}, respectively (F{sub ν}∝ν{sup α}), and construct spectral energy distributions during quiescent and active states. We analyze the relationships between different spectral indices, blazar classes, and activity states. We find (1) significantly steeper γ-ray spectra of FSRQs than for BL Lacs during quiescent states, but a flattening of the spectra for FSRQs during active states while the BL Lacs show no significant change; (2) a small difference of α{sub X} within each class between states, with BL Lac X-ray spectra significantly steeper than in FSRQs; (3) a highly peaked distribution of X-ray spectral slopes of FSRQs at ∼ –0.60, but a very broad distribution of α{sub X} of BL Lacs during active states; (4) flattening of the optical spectra of FSRQs during quiescent states, but no statistically significant change of α{sub o} of BL Lacs between states; and (5) a positive correlation between optical and γ-ray spectral slopes of BL Lacs, with similar values of the slopes. We discuss the findings with respect to the relative prominence of different components of high-energy and optical emission as the flux state changes.

  16. BL Lacertae Objects Beyond Redshift 1.3 - UV-to-NIR Photometry and Photometric Redshift for Fermi/LAT Blazars

    Science.gov (United States)

    Rau, A.; Schady, P.; Greiner, J.; Salvato, M.; Ajello, M.; Bottacini, E.; Gehrels, N.; Afonso, P. M. J.; Elliott, J.; Filgas, R.; hide

    2011-01-01

    Context. Observations of the gamma-ray sky with Fermi led to significant advances towards understanding blazars, the most extreme class of Active Galactic Nuclei. A large fraction of the population detected by Fermi is formed by BL Lacertae (BL Lac) objects, whose sample has always suffered from a severe redshift incompleteness due to the quasi-featureless optical spectra. Aims. Our goal is to provide a significant increase of the number of confirmed high-redshift BL Lac objects contained in the 2 LAC Fermi/LAT catalog. Methods. For 103 Fermi/LAT blazars, photometric redshifts using spectral energy distribution fitting have been obtained. The photometry includes 13 broad-band filters from the far ultraviolet to the near-IR observed with Swift/UVOT and the multi-channel imager GROND at the MPG/ESO 2.2m telescope. Data have been taken quasi-simultaneously and the remaining source-intrinsic variability has been corrected for. Results. We release the UV-to-near-IR 13-band photometry for all 103 sources and provide redshift constraints for 75 sources without previously known redshift. Out of those, eight have reliable photometric redshifts at z > or approx. 1.3, while for the other 67 sources we provide upper limits. Six of the former eight are BL Lac objects, which quadruples the sample of confirmed high-redshift BL Lac. This includes three sources with redshifts higher than the previous record for BL Lac, including CRATES J0402-2615, with the best-fit solution at z approx. = 1.9.

  17. Comprehensive monitoring of gamma-ray bright blazars. I. Statistical study of optical, X-ray, and gamma-ray spectral slopes

    International Nuclear Information System (INIS)

    Williamson, Karen E.; Jorstad, Svetlana G.; Marscher, Alan P.; Agudo, Iván; Joshi, Manasvita; Malmrose, Michael P.; Larionov, Valeri M.; Blinov, Dmitry A.; Efimova, Natalia V.; Hagen-Thorn, Vladimir A.; Konstantinova, Tatiana S.; Kopatskaya, Evgenia N.; Larionova, Elena G.; Larionova, Liudmilla V.; Smith, Paul S.; Arkharov, Arkady A.; Casadio, Carolina; Gómez, José L.; Molina, Sol N.; McHardy, Ian M.

    2014-01-01

    We present γ-ray, X-ray, ultraviolet, optical, and near-infrared light curves of 33 γ-ray bright blazars over 4 years that we have been monitoring since 2008 August with multiple optical, ground-based telescopes and the Swift satellite, and augmented by data from the Fermi Gamma-ray Space Telescope and other publicly available data from Swift. The sample consists of 21 flat-spectrum radio quasars (FSRQs) and 12 BL Lac objects (BL Lacs). We identify quiescent and active states of the sources based on their γ-ray behavior. We derive γ-ray, X-ray, and optical spectral indices, α γ , α X , and α o , respectively (F ν ∝ν α ), and construct spectral energy distributions during quiescent and active states. We analyze the relationships between different spectral indices, blazar classes, and activity states. We find (1) significantly steeper γ-ray spectra of FSRQs than for BL Lacs during quiescent states, but a flattening of the spectra for FSRQs during active states while the BL Lacs show no significant change; (2) a small difference of α X within each class between states, with BL Lac X-ray spectra significantly steeper than in FSRQs; (3) a highly peaked distribution of X-ray spectral slopes of FSRQs at ∼ –0.60, but a very broad distribution of α X of BL Lacs during active states; (4) flattening of the optical spectra of FSRQs during quiescent states, but no statistically significant change of α o of BL Lacs between states; and (5) a positive correlation between optical and γ-ray spectral slopes of BL Lacs, with similar values of the slopes. We discuss the findings with respect to the relative prominence of different components of high-energy and optical emission as the flux state changes.

  18. RESPONS SISWA KELAS VII TERHADAP PEMBELAJARAN TEKS LAPORAN HASIL OBSERVA SI DENGAN MEDIA VIDEO PENGETAHUAN

    Directory of Open Access Journals (Sweden)

    Nina Septia Rahmawati

    2017-08-01

    Full Text Available Learning Text Reports Observation with Media Video Knowledge has been implemented by one of Indonesion teachers in class in VII SMPN 19 Malang. To knows student responce on learning text reports observation with media video knowledge has been implemented, the student gived  Questionnaire. The purpose of the questionnaire is to determine the response of students to the use of video media knowledge in text learning reports the results of observation. The method used in this research is descriptive qualitative that is describe student response based on answer questionnaire. Based on the questionnaire responses from the four classes taught by the teacher concerned, it can be concluded that more students are claiming that the observational text of the observation report with the video media is good knowledge (B. There are also some minority students who stated quite well (C. The result of student questionnaire answers can be used as a reflection material for teachers to improve the quality of the next learning. Pembelajaran teks laporan observasi dengan media video pengetahuan telah dilaksanakan oleh salah satu guru Bahasa Indonesia di kelas VII SMPN 19 Malang. Untuk mengetahui respons siswa terhadap pembelajaran yang sudah dilakukan, siswa diberi angket. Tujuan dari pemberian angket tersebut adalah untuk mengetahui respons siswa terhadap penggunaan media video pengetahuan dalam pembelajaran teks laporan hasil observasi. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif yaitu mendeskripsikan respons siswa berdasarkan jawaban angket. Berdasarkan jawaban angket dari empat kelas yang diajar guru yang bersangkutan dapat disimpulkan bahwa lebih banyak siswa yang menyatakan bahwa pembelajaran teks laporan hasil observasi dengan media video pengetahuan baik (B. Ada juga beberapa minoritas siswa yang menyatakan cukup baik (C. Hasil jawaban angket siswa tersebut dapat dijadikan bahan refleksi bagi guru untuk meningkatkan kualitas

  19. Biological accumulations in archaeological sites: Amalda VII and Esquilleu III-IV

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    Yravedra Sainz de los Terreros, José

    2006-12-01

    Full Text Available Lithic and bone associations from Paleolithic sites are usually assumed to be episodes of human activity when taphonomic studies are not carried out. Nevertheless, such concentrations are occasionally caused by diverse agents. Here we present the study carried out on the bone assemblage of goat and chamois of the Palaeolithic sites of the level VII of Amalda Cave (Zestoa, Guipuzcoa and the III and IV of the Esquilleu Cave (Castro Cillorigo, Cantabria which are the result of a biological contribution by carnivores and not by humans. After each site is analysed and compared we can suggest which carnivore type produced these bone assemblages and propose some traits about carnivore behaviour observed in these assemblages.

    Es frecuente que las asociaciones líticas y óseas de los yacimientos paleolíticos sean asociadas con episodios de actividad antrópica, en los que es el ser humano fuera el principal responsable de dichas acumulaciones óseas. Sin embargo, en numerosas ocasiones tales concentraciones obedecen a procesos diferentes ocasionados por agentes diversos. En este caso, se dan argumentos que muestran como los restos osteológicos de Capra pyrenaica y Rupicapra rupicapra de los yacimientos paleolíticos del nivel VII de la cueva Amalda (Zestoa, Guipúzcoa y los III y IV de la cueva del Esquilleu (Castro Cillorigo, Cantabria, responden a un aporte biológico no humano.
    Tras ver esto, se comparan las evidencias presentadas en cada yacimiento con la información publicada sobre el comportamiento de los diferentes carnívoros, con el fin de diferenciar qué carnívoro es el responsable de las concentraciones óseas de cada yacimiento, para tratar de proponer al final del trabajo algunos rasgos diferenciales del comportamiento de los carnívoros sobre sus acumulaciones óseas.

  20. PENGEMBANGAN PERANGKAT PEMBELAJARAN ARITMETIKA SOSIAL BERBASIS PROBLEM BASED LEARNING DI KELAS VII SMP

    Directory of Open Access Journals (Sweden)

    Ruslan Ridwan

    2016-07-01

    Full Text Available The purpose of this study is aimeds to (1 produce the mathematics lesson plan based on social arithmetic Problem Based Learning (PBL in class VII in viewed from the aspects of validity and practicality and to know the potential effects arising from the development of the lesson plan, (2 describe the characteristics of the lesson plan based on social arithmetic Problem Based Learning. The method of the study was the development research according to the type of formative research by Tessmer. The stages of development were  Self Evaluation, prototyping and product. The subjects were VII.1 grade students of SMP Negeri 1 Muaradua semester 2014/2015 academic year, consistive of 31 people. Data collection techniques used were documentation, walk-throughs, observation sheets, and test results. Data were analyzed qualitatively and quantitatively. The results of data analysis showed that in the mathematics lesson plan based on social arimetika Problem Based Learning (PBL were valid, practical, and had a potential effect. The lesson plan had a valid learning in the content, construct, and language experts based on the results of the validation stage of the expert review and the prototype  test on a small group stage, while the practical lesson plan obtained  from the revised test results of one-to-one and small group. Potential effects of the lesson plan was  known from the results of the field test and the results of the student's final test. The results of the student's final test showed 45.16% of the students were is very good category, 32.26%  were  good category, and 22.58% fair category. From the result of observation, the percentage average of students’ activity was above 81,25% included in very good category.

  1. Women with congenital factor VII deficiency: clinical phenotype and treatment options from two international studies.

    Science.gov (United States)

    Napolitano, M; Di Minno, M N D; Batorova, A; Dolce, A; Giansily-Blaizot, M; Ingerslev, J; Schved, J-F; Auerswald, G; Kenet, G; Karimi, M; Shamsi, T; Ruiz de Sáez, A; Dolatkhah, R; Chuansumrit, A; Bertrand, M A; Mariani, G

    2016-09-01

    A paucity of data exists on the incidence, diagnosis and treatment of bleeding in women with inherited factor VII (FVII) deficiency. Here we report results of a comprehensive analysis from two international registries of patients with inherited FVII deficiency, depicting the clinical picture of this disorder in women and describing any gender-related differences. A comprehensive analysis of two fully compatible, international registries of patients with inherited FVII deficiency (International Registry of Factor VII deficiency, IRF7; Seven Treatment Evaluation Registry, STER) was performed. In our cohort (N = 449; 215 male, 234 female), the higher prevalence of mucocutaneous bleeds in females strongly predicted ensuing gynaecological bleeding (hazard ratio = 12.8, 95% CI 1.68-97.6, P = 0.014). Menorrhagia was the most prevalent type of bleeding (46.4% of patients), and was the presentation symptom in 12% of cases. Replacement therapies administered were also analysed. For surgical procedures (n = 50), a receiver operator characteristic analysis showed that the minimal first dose of rFVIIa to avoid postsurgical bleeding during the first 24 hours was 22 μg kg(-1) , and no less than two administrations. Prophylaxis was reported in 25 women with excellent or effective outcomes when performed with a total weekly rFVIIa dose of 90 μg kg(-1) (divided as three doses). Women with FVII deficiency have a bleeding disorder mainly characterized by mucocutaneous bleeds, which predicts an increased risk of ensuing gynaecological bleeding. Systematic replacement therapy or long-term prophylaxis with rFVIIa may reduce the impact of menorrhagia on the reproductive system, iron loss and may avoid unnecessary hysterectomies. © 2016 John Wiley & Sons Ltd.

  2. Keefektifan Strategi Pembelajaran React Pada Kemampuan Siswa Kelas VII Aspek Komunikasi Matematis

    Directory of Open Access Journals (Sweden)

    A.T. Arifin

    2014-06-01

    Full Text Available AbstrakTujuan penelitian ini adalah mengetahui pembelajaran dengan strategi REACT efektif ter-hadap kemampuan komunikasi matematis siswa. Metode pengumpulan data dilakukan de-ngan metode dokumentasi, tes, dan observasi. Hasil uji proporsi menunjukkan bahwa hasil belajar siswa kelas eksperimen pada aspek kemampuan komunikasi matematis telah men-capai ketuntasan klasikal, mencapai lebih dari 80 % yaitu sebesar 96,7%. Dilihat dari nilai rata-rata tes kemampuan komunikasi matematis kelas eksperimen  adalah 83,61 sedangkan kelas kontrol adalah 73,79 dapat disimpulkan bahwa kemampuan komunikasi matematis siswa kelas eksperimen lebih baik daripada kemampuan komunikasi matematis siswa kon-trol. Hasil penelitian menunjukkan bahwa penerapan strategi pembelajaran REACT efektif terhadap kemampuan komunikasi matematis siswa materi segiempat kelas VII SMP Negeri 1 Gembong. Kata kunci:      keefektifan, kemampuan komunikasi matematis, Relating Experiencing Applying Cooperating Transferring (REACT  AbstractThe purpose of this study was to determine the effectiveness of the application of REACT learning strategy approach to mathematic communication ability of students. Methods of data collection is done by the method of documentation, testing, and observation. The test results showed that the proportion of student learning outcomes in the experimental class with the aspects of mathematic communication ability has reached the classical completeness, reached more than 80% is equal to 96.7%. Judging from the value of the average test learners' ability to mathematic communication experimental class was 83.61 while the control class is 73.79 it can be concluded that the mathematic communication skills of learners experimental classes are better than mathematic communication abilities of learners control class. The results showed that the application of REACT learning strategy approach effective to mathematic communication abilities of students of class VII

  3. XMM-Newton Survey of Local O VII Absorption Lines in the Spectra of Galactic X-Ray Sources

    Science.gov (United States)

    Luo, Yang; Fang, Taotao; Ma, Renyi

    2018-04-01

    The detection of highly ionized metal absorption lines in the X-ray spectra of the Galactic X-ray binaries (XRBs) implies the distribution of hot gas along the sightline toward the background sources. However, the origin of this hot gas is still unclear: it can arise in the hot interstellar medium (ISM), or is intrinsic to the XRBs. In this paper, we present an XMM-Newton survey of the O VII absorption lines in the spectra of Galactic XRBs. A total of 33 XRBs were selected, with 29 low-mass XRBs and 4 high-mass XRBs. At a more than 3σ threshold, O VII absorption line was detected in 16 targets, among which 4 were newly discovered in this work. The average line equivalent width is centered around ∼20 mÅ. Additionally, we do not find strong correlations between the O VII EWs and the Galactic neutral absorption N H, the Galactic coordinates, or the distance of background targets. Such non-correlation may suggest contamination of the circumstellar material, or a lack of constraints on the line Doppler-b parameter. We also find that regardless of the direction of the XRBs, the O VII absorption lines are always detected when the flux of the background XRBs reaches a certain level, suggesting a uniform distribution of this hot gas. We estimate a ratio of 0.004–0.4 between the hot and neutral phases of the ISM. This is the second paper in the series following Fang et al. (2015), in which we focused on the local O VII absorption lines detected in the background AGN spectra. Detailed modeling of the hot ISM distribution will be investigated in a future paper.

  4. Biochemical characterization of VQ-VII, a cysteine peptidase with broad specificity, isolated from Vasconcellea quercifolia latex.

    Science.gov (United States)

    Torres, María José; Trejo, Sebastián Alejandro; Natalucci, Claudia Luisa; López, Laura María Isabel

    2013-06-01

    The latex from Vasconcellea quercifolia ("oak leaved papaya"), a member of the Caricaceae family, contains at least seven cysteine endopeptidases with high proteolytic activity, which helps to protect these plants against injury. In this study, we isolated and characterized the most basic of these cysteine endopeptidases, named VQ-VII. This new purified enzyme was homogeneous by bidimensional electrophoresis and MALDI-TOF mass spectrometry, and exhibited a molecular mass of 23,984 Da and an isoelectric point >11. The enzymatic activity of VQ-VII was completely inhibited by E-64 and iodoacetic acid, confirming that it belongs to the catalytic group of cysteine endopeptidases. By investigating the cleavage of the oxidized insulin B-chain to establish the hydrolytic specificity of VQ-VII, we found 13 cleavage sites on the substrate, revealing that it is a broad-specificity peptidase. The pH profiles toward p-Glu-Phe-Leu-p-nitroanilide (PFLNA) and casein showed that the optimum pH is about 6.8 for both substrates, and that in casein, it is active over a wide pH range (activity higher than 80 % between pH 6 and 9.5). Kinetic enzymatic assays were performed with the thiol peptidase substrate PFLNA (K m = 0.454 ± 0.046 mM, k cat = 1.57 ± 0.07 s(-1), k cat/K m = 3.46 × 10(3) ± 14 s(-1) M(-1)). The N-terminal sequence (21 amino acids) of VQ-VII showed an identity >70 % with 11 plant cysteine peptidases and the presence of highly conserved residues and motifs shared with the "papain-like" family of peptidases. VQ-VII proved to be a new latex enzyme of broad specificity, which can degrade extensively proteins of different nature in a wide pH range.

  5. A novel GUSB mutation in Brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis VII.

    Directory of Open Access Journals (Sweden)

    Marjo K Hytönen

    Full Text Available Hundreds of different human skeletal disorders have been characterized at molecular level and a growing number of resembling dysplasias with orthologous genetic defects are being reported in dogs. This study describes a novel genetic defect in the Brazilian Terrier breed causing a congenital skeletal dysplasia. Affected puppies presented severe skeletal deformities observable within the first month of life. Clinical characterization using radiographic and histological methods identified delayed ossification and spondyloepiphyseal dysplasia. Pedigree analysis suggested an autosomal recessive disorder, and we performed a genome-wide association study to map the disease locus using Illumina's 22K SNP chip arrays in seven cases and eleven controls. A single association was observed near the centromeric end of chromosome 6 with a genome-wide significance after permutation (p(genome= 0.033. The affected dogs shared a 13-Mb homozygous region including over 200 genes. A targeted next-generation sequencing of the entire locus revealed a fully segregating missense mutation (c.866C>T causing a pathogenic p.P289L change in a conserved functional domain of β-glucuronidase (GUSB. The mutation was confirmed in a population of 202 Brazilian terriers (p = 7,71×10(-29. GUSB defects cause mucopolysaccharidosis VII (MPS VII in several species and define the skeletal syndrome in Brazilian Terriers. Our results provide new information about the correlation of the GUSB genotype to phenotype and establish a novel canine model for MPS VII. Currently, MPS VII lacks an efficient treatment and this model could be utilized for the development and validation of therapeutic methods for better treatment of MPS VII patients. Finally, since almost one third of the Brazilian terrier population carries the mutation, breeders will benefit from a genetic test to eradicate the detrimental disease from the breed.

  6. [The coagulation factor VII gene polymorphisms in patients with myocardial infarction in Ningxia Hui and Han populations].

    Science.gov (United States)

    Huang, Hui; Jia, Shaobin; Chen, Shulan; Sha, Yong; Ma, Aiqun; Ma, Xueping; Zhang, Jinli; Bai, Xiangrong; He, Lin

    2009-12-01

    To investigate the characteristics for activated coagulation factor VII(F VIIa) and the R353Q, -323 0/10 bp, HVR4 polymorphisms in the gene in patients with coronary heart disease (CHD) and myocardial infarction from Ningxia Hui and Han populations. Four hundred and twenty angiographically proven CHD patients in the Hui population, and 508 healthy blood donors were tested for their plasma levels of coagulation factor VII using recombinant tissue factor method. The coagulation factor VII gene R353Q, -323 0/10 bp and HVR4 genotypes were identified by polymerase chain reaction. In addition, 600 Han patients with CHD and 604 healthy Han control subjects were also investigated. (1) The plasma F VIIa levels was significantly higher in patients with CHD and myocardial infarction than that in healthy control subjects and angor pectoris (PHui and Han populations. (2) There were significant differences in the distribution of genotypes and allelic frequencies of the R353Q between myocardial infarction and angor pectoris disease in the Hui population (PHui and Han population. (3) The F VIIa level was significantly higher in individuals with RR genotype than those of Q allele carriers in the Hui population. There are polymorphisms of the F VII gene R353Q, -323 0/10 bp and HVR4 in the Hui and Han populations. The Q allele might be a protective factor against myocardial infarction in the Hui, and the plasma F VIIa level may be influenced by the R353Q polymorphism of the F VII gene. The 10 allele may be a protective factor against myocardial infarction in both the Hui and Han populations.

  7. Type VII Collagen is Enriched in the Enamel Organic Matrix Associated with the Dentin-Enamel Junction of Mature Human Teeth

    Science.gov (United States)

    McGuire, Jacob D.; Walker, Mary P.; Mousa, Ahmad; Wang, Yong; Gorski, Jeff P.

    2014-01-01

    The inner enamel region of erupted teeth is known to exhibit higher fracture toughness and crack growth resistance than bulk phase enamel. However, an explanation for this behavior has been hampered by the lack of compositional information for the residual enamel organic matrix. Since enamel-forming ameloblasts are known to express type VII collagen and type VII collagen null mice display abnormal amelogenesis, the aim of this study was to determine whether type VII collagen is a component of the enamel organic matrix at the dentin-enamel junction (DEJ) of mature human teeth. Immunofluorescent confocal microscopy of demineralized tooth sections localized type VII collagen to the organic matrix surrounding individual enamel rods near the DEJ. Morphologically, immunoreactive type VII collagen helical-bundles resembled the gnarled-pattern of enamel rods detected by Coomassie Blue staining. Western blotting of whole crown or enamel matrix extracts also identified characteristic Mr=280 and 230 kDa type VII dimeric forms, which resolved into 75 and 25 kDa bands upon reduction. As expected, the collagenous domain of type VII collagen was resistant to pepsin digestion, but was susceptible to purified bacterial collagenase. These results demonstrate the inner enamel organic matrix in mature teeth contains macromolecular type VII collagen. Based on its physical association with the DEJ and its well-appreciated capacity to complex with other collagens, we hypothesize that enamel embedded type VII collagen fibrils may contribute not only to the structural resilience of enamel, but may also play a role in bonding enamel to dentin. PMID:24594343

  8. Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

    DEFF Research Database (Denmark)

    Holst, B; Elling, C E; Schwartz, T W

    2000-01-01

    -ion site located between AspIII:08-or a His residue introduced at this position in transmembrane domain (TM)-III-and a Cys residue substituted for AsnVII:06 in TM-VII. Here, this interhelical, bidentate metal-ion site is without loss of Zn(2+) affinity transferred to the tachykinin NK(1) receptor...... metal-ion binding residues located at positions III:08 and VII:06. It is suggested that only partial agonism is obtained through this simple well defined metal-ion coordination due to lack of proper interactions with residues also in TM-VI....

  9. A new automated method for continuous registration of factor VII activation in vitro. Activation is accelerated by the concentration of factor VII and the activity state of the protein

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Jespersen, J; Gram, J

    1994-01-01

    When a plasma sample is exposed to tissue factor, single-chain factor VII (FVII) is gradually converted to the active two-chain form (FVIIa). In the present study, we have constructed a measurement system, which allows continuous registration of the activation of FVII to FVIIa in vitro....... In this system, FVII activation follows parabolic kinetic after an initial lag-phase. The slope of the linear phase is a measure of the protein concentration of factor VII (FVIItotal), while the length of the non-linear phase represents the velocity of FVII activation. The time required for complete activation...... of FVII is inversely related to both FVIItotal and the relative amount of FVIIa in the sample. In future studies, this new measurement system will make it possible to study the process of FVII activation in different samples, and to examine how varying concentrations of exogenous added components affect...

  10. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    Science.gov (United States)

    Chadwick, M. B.; Obložinský, P.; Herman, M.; Greene, N. M.; McKnight, R. D.; Smith, D. L.; Young, P. G.; MacFarlane, R. E.; Hale, G. M.; Frankle, S. C.; Kahler, A. C.; Kawano, T.; Little, R. C.; Madland, D. G.; Moller, P.; Mosteller, R. D.; Page, P. R.; Talou, P.; Trellue, H.; White, M. C.; Wilson, W. B.; Arcilla, R.; Dunford, C. L.; Mughabghab, S. F.; Pritychenko, B.; Rochman, D.; Sonzogni, A. A.; Lubitz, C. R.; Trumbull, T. H.; Weinman, J. P.; Brown, D. A.; Cullen, D. E.; Heinrichs, D. P.; McNabb, D. P.; Derrien, H.; Dunn, M. E.; Larson, N. M.; Leal, L. C.; Carlson, A. D.; Block, R. C.; Briggs, J. B.; Cheng, E. T.; Huria, H. C.; Zerkle, M. L.; Kozier, K. S.; Courcelle, A.; Pronyaev, V.; van der Marck, S. C.

    2006-12-01

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes, based on experimental data and theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, 6Li, 10B, Au and for 235,238U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced evaluations up to 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; (10) New methods for uncertainties and covariances, together with covariance evaluations for some sample cases; and (11) New actinide fission energy deposition. The paper provides an overview of this library, consisting of 14 sublibraries in the same ENDF-6 format as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched uranium thermal assemblies is removed; (b) The 238U and 208Pb reflector biases in fast systems are largely removed; (c) ENDF/B-VI.8 good

  11. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    International Nuclear Information System (INIS)

    Chadwick, M.B.; Oblozinsky, P.; Herman, M.

    2006-01-01

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes, based on experimental data and theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, 6 Li, 10 B, Au and for 235,238 U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced evaluations up to 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; (10) New methods for uncertainties and covariances, together with covariance evaluations for some sample cases; and (11) New actinide fission energy deposition. The paper provides an overview of this library, consisting of 14 sublibraries in the same ENDF-6 format as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched uranium thermal assemblies is removed; (b) The 238 U and 208 Pb reflector biases in fast systems are largely removed; (c) ENDF/B-VI.8 good

  12. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, M B; Oblozinsky, P; Herman, M; Greene, N M; McKnight, R D; Smith, D L; Young, P G; MacFarlane, R E; Hale, G M; Haight, R C; Frankle, S; Kahler, A C; Kawano, T; Little, R C; Madland, D G; Moller, P; Mosteller, R; Page, P; Talou, P; Trellue, H; White, M; Wilson, W B; Arcilla, R; Dunford, C L; Mughabghab, S F; Pritychenko, B; Rochman, D; Sonzogni, A A; Lubitz, C; Trumbull, T H; Weinman, J; Brown, D; Cullen, D E; Heinrichs, D; McNabb, D; Derrien, H; Dunn, M; Larson, N M; Leal, L C; Carlson, A D; Block, R C; Briggs, B; Cheng, E; Huria, H; Kozier, K; Courcelle, A; Pronyaev, V; der Marck, S

    2006-10-02

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes. The new evaluations are based on both experimental data and nuclear reaction theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, {sup 6}Li, {sup 10}B, Au and for {sup 235,238}U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced reactions up to an energy of 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; and (10) New methods developed to provide uncertainties and covariances, together with covariance evaluations for some sample cases. The paper provides an overview of this library, consisting of 14 sublibraries in the same, ENDF-6 format, as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched U thermal assemblies is removed; (b) The {sup 238}U, {sup 208}Pb, and {sup 9}Be reflector

  13. Theoretical emission line ratios for [Fe III] and [Fe VII] applicable to the optical and infrared spectra of gaseous nebulae.

    Science.gov (United States)

    Keenan, F P; Aller, L H; Ryans, R S; Hyung, S

    2001-08-14

    Recent calculations of electron impact excitation rates and Einstein A-coefficients for transitions among the 3d(6) levels of Fe III and among the 3d(2) levels of Fe VII are used to derive theoretical emission line ratios applicable to the optical and infrared spectra of gaseous nebulae. Results for [Fe III] are generated for electron temperatures T(e) = 7,000-20,000 K and densities N(e) = 10(2)-10(8) cm(-3), whereas those for [Fe VII] are provided for T(e) = 10,000-30,000 K and N(e) = 10(2)-10(8) cm(-3). The theoretical line ratios are significantly different in some instances from earlier calculations and resolve discrepancies between theory and observation found for the planetary nebulae IC 4997 and NGC 7027.

  14. PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

    Directory of Open Access Journals (Sweden)

    Apri Dwi Astuti

    2012-10-01

    Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

  15. Publication and dating of Parts IV-VII of Brauer & Bergenstamm's Die Zweiflügler des Kaiserlichen Museums zu Wien (1889-1894).

    Science.gov (United States)

    Evenhuis, Neal L

    2014-04-22

    Based on new evidence, the dates of publication of the journal and separate versions of parts IV-VII of Brauer & Bergenstamm's Die Zweiflügler des Kaiserlichen Museums zu Wien are given, correcting those dates previously published.

  16. Brownian motion - a laboratory experiment

    Science.gov (United States)

    Kruglak, Haym

    1988-09-01

    The availability of latex microspheres, compact television cameras and electronic calculators make it possible to perform an experiment on Brownian movement in one laboratory period. A more accurate value of N can be determined by other methods. However, the experiment described above has several valuable pedagogical outcomes. Undergraduate students get experience with several experimental techniques: (i) recording a `random walk' of a microphere; (ii) plotting a histogram of displacements; (iii) fitting a Gaussian curve to the histogram; (iv) checking the goodness of fit analytically or with probability graph paper; (v) calibrating screen displacements with a diffraction grating; (vi) calculating Avogadro's number from the experimental data; (vii) verifying data validity with the Einstein - Smoluchowski Law. The experiment also provides valuable practice in unit conversion and error analysis. Another instructive feature: the experiment makes the students aware of Einstein's work other than relativity. The students' reactions to the experiment were positive: `interesting', `challenging', `fun'.

  17. Development of a Neo-Epitope Specific Assay for Serological Assessment of Type VII Collagen Turnover and Its Relevance in Fibroproliferative Disorders.

    Science.gov (United States)

    Sand, Jannie M B; Lamy, Patricia; Juhl, Pernille; Siebuhr, Anne Sofie; Iversen, Line V; Nawrocki, Arkadiusz; Larsen, Martin R; Domsic, Robyn T; Franchimont, Nathalie; Chavez, Juan; Karsdal, Morten A; Leeming, Diana J

    2018-03-01

    Type VII collagen is the main component of the anchoring fibrils connecting the basement membrane to the underlying interstitial matrix. Mutations in the type VII collagen gene cause dystrophic epidermolysis bullosa. Increased levels of type VII collagen in the skin have been reported in patients with systemic sclerosis (SSc), whereas reduced levels in the airways have been related to asthma. This indicates that type VII collagen plays an important part in upholding tissue integrity and that its remodeling may lead to pathological states. The aim of this study was to investigate the role of type VII collagen remodeling in fibroproliferative disorders. We produced monoclonal antibody targeting a specific fragment of type VII collagen (C7M) released to the systemic circulation and developed a neo-epitope specific competitive enzyme-linked immunosorbent assay (ELISA). Biological relevance was evaluated in serum from patients with SSc or chronic obstructive pulmonary disease (COPD). The C7M ELISA was technically robust and specific for the C7M neo-epitope. Serum C7M levels were significantly elevated in two cohorts of patients with SSc and in patients with COPD as compared with healthy individuals (P collagen turnover in serum. Elevated serum C7M levels indicated that the turnover rate of type VII collagen was significantly increased in patients with SSc or COPD, suggesting a pathological role. Thus, the C7M ELISA may become useful in future investigations of type VII collagen turnover in fibroproliferative disorders, and it may prove a valuable tool for evaluating novel anti-fibrotic drugs.

  18. Combined congenital dysfibrinogenemia and factor VII deficiency from mutations in the FGB and F7 genes.

    Science.gov (United States)

    Woo, Hye In; Park, In-Ae; Lee, Ki-O; Kim, Sun-Hee; Kim, Hee-Jin

    2012-07-01

    Dysfibrinogenemia and factor VII (FVII) deficiency are rare congenital coagulopathies. In this report, the authors describe a man with both defects confirmed by molecular genetic tests. The patient was a 51-year-old man referred for prolonged prothrombin time (PT) that had been accidentally detected on preoperative screening. He had no history of bleeding tendency even on occasions of surgery. Routine coagulation studies revealed prolonged PT (1.53 INR) and thrombin time (42.2 s), and decreased fibrinogen level (57 mg/dl) and FVII activity (44%). Direct sequencing analyses were performed on FGA, FGB, and FGG genes to confirm dysfibrinogenemia and on the F7 gene to confirm FVII deficiency. As a result, the patient was shown to be heterozygous for a point mutation in exon 8 of the FGB gene (c.1475A > G, p.*492Trpext*12; Fibrinogen Magdeburg II) and for a missense mutation in exon 6 of the F7 gene (c.466G  > A, p.Gly156Ser). To our knowledge, this is the first report on a case of combined dysfibrinogenemia and FVII deficiency confirmed by molecular genetic tests.

  19. Prevalence of factor VII deficiency and molecular characterization of the F7 gene in Brazilian patients.

    Science.gov (United States)

    Rodrigues, Dalva N; Siqueira, Lucia H; Galizoni, Andréa M; Arruda, Valder R; Annichino-Bizzacchi, Joyce M

    2003-04-01

    The prevalence of factor VII (FVII) deficiency in 267 Brazilian patients was estimated to be 4.1%, including one patient with significant bleeding, five with minor bleeding and five patients asymptomatic. Only one novel mutation 8926G F7 polymorphisms and FVII activity were found in these patients, as those with higher levels of FVII activity presented the genotype described in the literature as related to reduced FVII activity. As the R304Q mutation was the most frequent in these patients, and may be associated with an asymptomatic form of the disease, particularly in Blacks, we examined this mutation and FVII activity in 49 Blacks and 49 Caucasian blood donors with no clinical bleeding. None of the individuals showed the R304Q mutation, and FVII activity was normal in all of them, thus indicating that FVII deficiency is not common in normal individuals of these two ethnic groups in Brazil. This is the first study in South America to examine the prevalence and molecular basis of FVII deficiency, including the description of a novel mutation.

  20. Large deletions play a minor but essential role in congenital coagulation factor VII and X deficiencies.

    Science.gov (United States)

    Rath, M; Najm, J; Sirb, H; Kentouche, K; Dufke, A; Pauli, S; Hackmann, K; Liehr, T; Hübner, C A; Felbor, U

    2015-01-01

    Congenital factor VII (FVII) and factor X (FX) deficiencies belong to the group of rare bleeding disorders which may occur in separate or combined forms since both the F7 and F10 genes are located in close proximity on the distal long arm of chromosome 13 (13q34). We here present data of 192 consecutive index cases with FVII and/or FX deficiency. 10 novel and 53 recurrent sequence alterations were identified in the F7 gene and 5 novel as well as 11 recurrent in the F10 gene including one homozygous 4.35 kb deletion within F7 (c.64+430_131-6delinsTCGTAA) and three large heterozygous deletions involving both the F7 and F10 genes. One of the latter proved to be cytogenetically visible as a chromosome 13q34 deletion and associated with agenesis of the corpus callosum and psychomotor retardation. Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII/FX deficiency, a deletion of the two contiguous genes might be part of a larger chromosomal rearrangement.

  1. Factor VII Deficiency: From Basics to Clinical Laboratory Diagnosis and Patient Management.

    Science.gov (United States)

    Sevenet, Pierre-Olivier; Kaczor, Daniel A; Depasse, Francois

    2017-10-01

    Factor VII (FVII) deficiency is a rare inheritable bleeding disorder affecting 1/500 000 individuals. Clinical manifestations are heterogeneous, from asymptomatic to severe and potentially fatal bleeding. These clinical manifestations do not correlate well with FVII plasma levels. For this reason, FVII-deficient patient management during surgery or for long-term prophylaxis remains challenging. Laboratory testing for FVII activity is, however, the first-line method for FVII deficiency diagnosis and is helpful for managing patients in combination with clinical history. Additional testing consists of FVII immunoassay and genetic testing. Genetic abnormalities on the FVII gene are heterogeneous and can translate into quantitative or qualitative defects. Some of the latter can react differently with different thromboplastins; this can be misleading for the laboratory as no consensus exists at present on an FVII deficiency diagnosis methodology. Indeed, no single test is able to predict accurately the bleeding risk. This review provides a broad picture of inherited and acquired FVII deficiency with a particular focus on laboratory diagnosis.

  2. Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    Benjamin Mielich-Süss

    2017-11-01

    Full Text Available Scaffold proteins are ubiquitous chaperones that promote efficient interactions between partners of multi-enzymatic protein complexes; although they are well studied in eukaryotes, their role in prokaryotic systems is poorly understood. Bacterial membranes have functional membrane microdomains (FMM, a structure homologous to eukaryotic lipid rafts. Similar to their eukaryotic counterparts, bacterial FMM harbor a scaffold protein termed flotillin that is thought to promote interactions between proteins spatially confined to the FMM. Here we used biochemical approaches to define the scaffold activity of the flotillin homolog FloA of the human pathogen Staphylococcus aureus, using assembly of interacting protein partners of the type VII secretion system (T7SS as a case study. Staphylococcus aureus cells that lacked FloA showed reduced T7SS function, and thus reduced secretion of T7SS-related effectors, probably due to the supporting scaffold activity of flotillin. We found that the presence of flotillin mediates intermolecular interactions of T7SS proteins. We tested several small molecules that interfere with flotillin scaffold activity, which perturbed T7SS activity in vitro and in vivo. Our results suggest that flotillin assists in the assembly of S. aureus membrane components that participate in infection and influences the infective potential of this pathogen.

  3. On modular stellarator coils of the W VII-AS type with reactor dimensions

    International Nuclear Information System (INIS)

    Hermeyer, E.; Kisslinger, J.; Rau, F.; Wobig, H.

    1985-01-01

    Modular Stellarator coil systems of the W VII-AS type with reactor dimensions are investigated. They comprise 5 field periods with 6 to 18 coils within each. Two groups of configurations are compared. The first group is characterized by the major torus radius of R 0 = 25.5 m and a distance between plasma and coils of ccdcc 1.8 m. The field on plasma axis amounts to B 3 = 5.3 T. In the second group the geometric dimensions are decreased. The major torus radius amounts to R 3 = 15.2 m, and a distance of about 1.2 m is chosen between plasma and coils. The field on plasma axis is enlarged to B 3 = 7 T. The total stored magnetic energy of the coil systems and the maximum magnetic flux density at the coils are calculated. Furthermore, the magnetic forces and mechanical stresses are evaluated, and two different support concepts for the coils are investigated: A single coil support scheme (outer and lateral support elements plus elastic padding), as well as a novel scheme of mutual coil support

  4. PENGEMBANGAN SOAL MATEMATIKA MODEL TIMSS UNTUK MENDUKUNG PEMBELAJARAN MATEMATIKA SMP KELAS VII KURIKULUM 2013

    Directory of Open Access Journals (Sweden)

    M. Andy Rudhito

    2016-02-01

    DEVELOPING THE TIMSS MATH PROBLEM MODEL TO SUPPORT THE MATHEMATICS LEARNING IN GRADE VII USING THE 2013 CURRICULUM Abstract: This study was aimed to produce a valid and practical TIMMS math problem model for junior high school students using the 2013 curriculum. The study used the research and development design. The design process of the problems as assessment instruments was carried out through prototyping involving two stages. Prototype I was the design product and the problem development done by the researchers themselves, while Prototype II was the revision of Prototype I based on the feedback provided by experts, colleagues, and Mathematics teachers in the form of validators’ notes and the minutes taken from discussions. The findings showed that the book of math problems was written by grouping the chapters following the materials domains as those in TIMSS, that is, numbers, geometry, algebra, data, and probability. For the student book, it was not nsecessary to write the materials domain, the essential topics, and the cognitive domain. The feedback from the FGD was that the problems should be arranged from the easiest ones to the most difficult ones. The multiple choice items should not be written in the form of questions, but in the form of incomplete sentences with the blanks in the middle or the end of the sentences. The items should not ask about implication. Keywords: Development of problems, junior high school mathematics, TIMSS, Curriculum 2013

  5. Factor VII activating protease (FSAP) promotes the proteolysis and inhibition of tissue factor pathway inhibitor (TFPI)

    Science.gov (United States)

    Kanse, Sandip M.; Declerck, Paul J.; Ruf, Wolfram; Broze, George; Etscheid, Michael

    2013-01-01

    Objectives Factor VII activating protease (FSAP) activates FVII as well as pro-urokinase and inhibits platelet-derived growth factor-BB, thus regulating haemostasis- and remodeling-associated processes in the vasculature. A genetic variant of FSAP (Marburg I polymorphism) results in low enzymatic activity and is associated with an enhanced risk for carotid stenosis and stroke. We postulate that there are additional substrates for FSAP that will help to explain its role in vascular biology and have searched for such a substrate. Results and Methods Using screening procedures to determine the influence of FSAP on various haemostasis-related processes on endothelial cells we discovered that FSAP inhibited tissue factor pathway inhibitor (TFPI), a major anti-coagulant secreted by these cells. Proteolytic degradation of TFPI by FSAP could also be demonstrated by Western blotting and the exact cleavage sites were determined by N-terminal sequencing. The Marburg I variant of FSAP had a diminished ability to inhibit TFPI. A monoclonal antibody to FSAP, that specifically inhibited FSAP binding to TFPI, reversed the inhibitory effect of FSAP on TFPI. Conclusions The identification of TFPI as a sensitive substrate for FSAP increases our understanding of its role in regulating haemostasis and proliferative remodeling events in the vasculature. PMID:22116096

  6. PEMBELAJARAN MATEMATIKA POKOK BAHASAN RATA-RATA HITUNG MENGGUNAKAN PENDEKATAN PMRI DI KELAS VII

    Directory of Open Access Journals (Sweden)

    Aditin Putria

    2015-08-01

    Full Text Available Penelitian ini merupakan penelitian deskriptif yang menggambarkan hasil belajar siswa pada pembelajaran Matematika pokok bahasan rata-rata hitung menggunakan pendekatan Pendidikan Matematika Realistik Indonesia (PMRI di kelas VII.A SMP Negeri 1 Pangkalpinang. Proses pembelajaran, hasil belajar, dan penilaian hasil belajar yang dilakukan berpedoman pada  kurikulum 2013. Hasil dan pembahasan menunjukkan (1 keaktifan siswa dalam proses belajar 65% berkategori baik, berdasarkan observasi aktivitas siswa saat proses menunjukkan siswa mendengarkan atau memperhatikan penjelasan guru dan teman dengan aktif, menyelesaikan masalah, membandingkan jawaban atau berdiskusi dengan teman, berani mengkomunikasikan ide, serta bertanya atau menanggapi pertanyaan teman/guru;(2 hasil belajar pada ranah sikap selama proses, pengetahuan, dan keterampilan unjuk kerja dari 33 orang siswa menunjukkan ketuntasan dengan persentase 100%. Hasil belajar pada ranah sikap selama proses pembelajaran menunjukkan siswa mencapai ketuntasan untuk sikap jujur dan tanggungjawab dalam kelompok dengan predikat Baik (B. Hasil belajar keterampilan unjuk kerja dinilai menggunakan instrumen skala penilaian (rating scale. Hasil belajar 33 siswa pada ranah pengetahuan menggunakan tes formatif sebagai instrumen penilaian pengetahuan memberikan umpan balik bagi usaha perbaikan kualitas pembelajaran di kelas, didukung dengan bahan ajar yang menghasilkan tiga strategi siswa dalam menyelesaikan masalah terkait rata-rata yaitu menggunakan rumus rata-rata, leveling, dan ‘tebak dan cek’ (guess and check. Kata-kata kunci : Rata-rata hitung, PMRI, Kurikulum 2013, Hasil belajar. DOI: http://dx.doi.org/10.22342/jpm.9.2.2430.148 - 161

  7. Peningkatan Kemampuan Menulis Cerita Pendek Melalui Pendekatan Kontekstual Pada Siswa SMP Kelas VII

    Directory of Open Access Journals (Sweden)

    Jatuh Padmi

    2017-05-01

    The objective of this research was to improve the short story writing ability at grade VII student of one private junior high school in Jakarta of the 2014/2015 Academic Year through contextual approach, both process and outcomes of learning. It was an action research with mix-method research.(qualitative and quantitative. It used Kemmis & Taggart’s action research model  which consists of four stages, namely planning, action, observation, and reflection and held in 3 cycles. The data were collected through short stories written tests, observation, interview, student’s journaling, and documentation. Qualitatf data was analyzed by describing the process of action research and the quality of student’s ability in short stories writing through contextual approach, while qualitative data was analyzed using the percentage of the normal distribution. The results showed an increase in the short stories writing ability through contextual approach ranging from pre-action, cycle 1, cycle 2 and cycle 3 seen from the average score, categorization, and the average score of short stories aspects of assessment.

  8. VII International Symposium and Young Scientists School “Modern Problems of Laser Physics”

    International Nuclear Information System (INIS)

    2017-01-01

    General Information This volume of the Journal is devoted to the VII International Symposium and Young Scientists School “Modern Problems of Laser Physics” (MPLP-2016). I was held in Novosibirsk Akademgorodok, Russia, 22–28 August 2016. Akademgorodok is the well-known Siberian Scientific Centre of Russian Academy of Sciences (RAS). It was founded in 1957. Since that time it is the place of many international scientific meetings, because it reflects the unique and fruitful symbiosis of many research institutions and Novosibirsk State University at one territory. Since the first MPLP meeting in 1995 the Symposium usually gathers scientists from many countries, carrying out their investigations at the forefront of laser physics, quantum metrology and high-resolution spectroscopy, physics of ultracold atoms, molecules and ions, atom optics, ultrafast phenomena and attoscience, quantum optics and information, nonlinear optics and applications of laser radiation from THz to UV radiation ranges in medicine, geophysics, chemistry and microbiology. Traditionally the Symposium is the place where scientists can discuss new trends in modern laser physics, generate new ideas as well as initiate further collaborations. (paper)

  9. Calculation of resonant effects in electron impact excitation of positive ions: Application to oxygen VII

    International Nuclear Information System (INIS)

    Pindzola, M.S.; Temkin, A.; Bhatia, A.K.

    1979-01-01

    The general reaction theory of Feshbach is applied to the calculation of resonant effects in near-threshold electron--positive-ion excitation. The theory divides configuration space into open- and closed-channel parts, resonance effects being described by the closed-channel part. The open-channel part is handled in a distorted-wave approximation to the set of open-channel coupled equations. We suggest various methods for handling the closed-channel part. However, we explicitly use an ''attached-excited-target approximation,'' which we further approximate by a set of uncoupled closed-channel equations. As an example, we calculate the 1 1 S → 2 1 P excitation cross section of O VII below the 3 3 S threshold. Various distorted-wave approximations are investigated and results from most of them are quite similar. Resonant effects arising from the attachment of the colliding electron with the 3 3 S state are found to be small, but other close-lying n = 3 states have not yet been included

  10. FREQUENCY DEFORMITY SCOLIOSIS AND FLAT FEET IN PUPILS III, V.VII GRADE SCHOOL

    Directory of Open Access Journals (Sweden)

    Dejаn Gojković

    2013-07-01

    Full Text Available Scoliosis is a lateral deviation of the spine or the angular deviation of the normal position of one or more segmenata.Funkcional curve can be fully corrected until the internal structural scoliosis are bone disorders, muscle nerve elements that support the spine, and complete correction is impossible. Static role is reflected in the foot taking kisses body weight through the bones pop and transmission and distribution of weight on the main point of support of the foot and therefore subject to various changes in the normal foot status.Dinamic role is reflected in walking, running and jumping in different forms. Because of this, the percentage of foot disorders is particularly large in the form of lowering the testing we arche.Perform o.š.Pale Pale deformities in scoliosis and flat feet in students III, V, VII grade. Our aim was to verify the extent to which physical education classes take appropriate measures in the detection and removal of poor posture and physical deformities. For testing we used: clinical method for scoliosis, a method for flat feet -Thomson method.

  11. Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony.

    Science.gov (United States)

    Carlstrom, Lucas P; Jens, Jackie K; Dobyns, Marley E; Passage, Merry; Dickson, Patricia I; Ellinwood, N Matthew

    2009-08-01

    Issues of cost and genetics can result in inbreeding of canine genetic disease colonies. Beagles often are used to maintain such colonies, providing stock for outcrosses. Factor VII (FVII) deficiency is a hemostatic disorder found at increased frequency in beagles and has been characterized at the DNA level. Deficiency of FVII presents obstacles in colonies founded with beagles. An initial finding of a FVII-deficient pup from a longstanding colony prompted us to evaluate FVII deficiency fully in this colony. Current and archival records and tissues were used to reconstruct the colony pedigree, assess the contribution from beagles, and test samples to document the source and frequency of the mutant FVII allele. As part of this study we developed a PCR-based diagnostic assay that was simpler than what was previously available. Pedigree analysis revealed a founder effect implicating beagles that led to high frequency (55%) of the mutant allele. In addition, affected animals were identified. The complete picture of the clinical effect within the colony remains unclear, but unusual neonatal presentations, including hemoabdomen, have occurred in pups affected with FVII deficiency. Use of a PCR-based diagnostic assay to screen all potential beagle breeding stock will prevent similar occurrences of FVII deficiency in future canine research colonies.

  12. Mode and sawtooth behaviour during neutral beam injection in the W VII-A stellarator

    International Nuclear Information System (INIS)

    Grieger, G.; Renner, H.; Sapper, J.; Wobig, H.; Dorst, D.; Cattanei, G.; Javel, P.; Rau, F.; Zippe, M.; Jaeckel, H.

    1980-02-01

    The mode behaviour during Neutral Beam Injection in the WENDELSTEIN VII-A stellarator is presented. The analysis is mainly relying on soft X-ray measurements. Two types of discharges were found during Neutral Beam Injection with plasma currents >= 20 kA. The first type is dominated by large, regular and long sawteeth, which are caused by a (m,n) = (1,1) mode. In the second type the sawteeth disappear completely. Later in the discharge a local disruption causes a transition to the first type; this disruption has a (3,2) mode precursor. A new mode (2,2) is found and phase coupled to the (3,2) mode. Even at a high external rotational transform (t 0 = 0.23) a large (2,1) mode is found after the (3,2) mode has caused the local disruption. At slightly lower external rotational transform values major current disruptions may even occur. This is mainly due to the enhanced edge heating by the Neutral Beam Injection. Results of simulations of the mode structures are also presendet. (orig./GG)

  13. Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

    Science.gov (United States)

    Beckham, Katherine S H; Ciccarelli, Luciano; Bunduc, Catalin M; Mertens, Haydyn D T; Ummels, Roy; Lugmayr, Wolfgang; Mayr, Julia; Rettel, Mandy; Savitski, Mikhail M; Svergun, Dmitri I; Bitter, Wilbert; Wilmanns, Matthias; Marlovits, Thomas C; Parret, Annabel H A; Houben, Edith N G

    2017-04-10

    Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids 1 . To transport substrates across this complex cell envelope, mycobacteria rely on type VII (also known as ESX) secretion systems 2 . In Mycobacterium tuberculosis, these ESX systems are essential for growth and full virulence and therefore represent an attractive target for anti-tuberculosis drugs 3 . However, the molecular details underlying type VII secretion are largely unknown, due to a lack of structural information. Here, we report the molecular architecture of the ESX-5 membrane complex from Mycobacterium xenopi determined at 13 Å resolution by electron microscopy. The four core proteins of the ESX-5 complex (EccB 5 , EccC 5 , EccD 5 and EccE 5 ) assemble with equimolar stoichiometry into an oligomeric assembly that displays six-fold symmetry. This membrane-associated complex seems to be embedded exclusively in the inner membrane, which indicates that additional components are required to translocate substrates across the mycobacterial outer membrane. Furthermore, the extended cytosolic domains of the EccC ATPase, which interact with secretion effectors, are highly flexible, suggesting an as yet unseen mode of substrate interaction. Comparison of our results with known structures of other bacterial secretion systems demonstrates that the architecture of type VII secretion system is fundamentally different, suggesting an alternative secretion mechanism.

  14. Mathematical Communication Ability by Grade VII Students Using a Themed Problem Based Learning with Scaffolding on Rectangle Materials

    Directory of Open Access Journals (Sweden)

    Didik Adi Saputro

    2017-08-01

    Full Text Available The aim of research to test students' mathematical communication used themed of PBL with scaffolding, themed of PBL and PBL achieve mastery learning;to test students' mathematical communication that used the themed of PBL with scaffolding, themed of PBL and PBL; and to test students' mathematical communication for the low, medium group, and a high-group themed of PBL with scaffolding, themed of PBL and PBL. This type of research is quantitative research. The Population is seventh grade students of SMPN 22 Semarang and the sample class VII E, F and VII VII G. Used normality test, homogenity test, equality test on average, the proportion of one-party test, one way anova test, and scheffe test. The results showed that (1 Student’s mathematical communication ability using themed of PBLwith Scaffolding strategy,themed of PBL, and PBL achieve the completeness of learning, (2 there is a difference in the classroom using the themed of PBL with scaffolding, themed of PBL, as well as PBL, (3 For the low, medium, high and there is a difference in the classroom using the themed of PBL with scaffolding, themed of PBL and PBL.

  15. The discovery of an O VII emission line in the ASCA spectrum of the Seyfert galaxy NGC 3783

    Science.gov (United States)

    George, I. M.; Turner, T. J.; Netzer, H.

    1995-01-01

    We report the first observation of an O VII 0.57 keV emission line in a Seyfert 1 galaxy. NGC 3783 was observed by ASCA twice over a period of 4 days in 1993 December. The source exhibited a approximately 30% change in intensity between the two observations, with most of the variability taking place as a result of steepening of the continuum less than or approximately equal to 1 keV. Spectra from both observations show intense absorption features in the 0.5-1.5 keV band, which can be well fitted by an ionized absorber model of solar composition, column density of 10(exp 22.2)/sq cm and ionization parameter of approximately 7-8; the strongest absorption features being due to O VII and O VIII. Two emission features are also seen in the spectra which we identify as O VII 0.57 keV (equivalent width approximately equals 36 eV) and O VIII 0.65 keV (equivalent width approximately equals 11 eV). We also show that the 3-6 keV continuum of the source is well fitted by a Gamma = 1.3-1.4 power-law continuum, a narrow neutral iron K-shell fluorescence line and a strong iron K-shell absorption edge, possibly corresponding to highly ionized iron.

  16. A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies.

    Science.gov (United States)

    Hashimoto, T; Ishiko, A; Shimizu, H; Tanaka, T; Dodd, H J; Bhogal, B S; Black, M M; Nishikawa, T

    1996-02-01

    In this study we present a patient with the sublamina densa type of linear IgA bullous dermatosis (LABD), with IgA autoantibodies reactive with the 290-kDa type VII collagen (the epidermolysis bullosa acquisita (EBA) antigen) and with immunoblotting of normal human dermal extracts. The clinical and histological features of the present case were compatible with those of LABD but quite different from those of EBA. Although EBA sera reacted with the bacterial fusion protein of the N-terminal globular (NC1) domain of type VII collagen, this patient's serum did not show reactivity. Furthermore, ultrastructural localization of target epitopes on the anchoring fibrils in this patient was considerably different from EBA. These results indicate that, whereas EBA antibodies react with the NC1 domain of type VII collagen, the epitope in this case is different from that of EBA (and is most likely on the central triple helical domain). This difference may be responsible for the clinical presentation in this patient being distinct from that of EBA.

  17. Comparison with adsorption of Re (VII) by two different γ-radiation synthesized silica-grafting of vinylimidazole/4-vinylpyridine adsorbents

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, Pu [Beijing Key Laboratory for Solid Waste Utilization and Management, Department of Energy and Resources Engineering, College of Engineering, Peking University, Beijing 100871,China (China); Han, Dong; Zhai, Maolin [Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, The Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China); Xu, Ling, E-mail: lingxu@pku.edu.cn [Beijing Key Laboratory for Solid Waste Utilization and Management, Department of Energy and Resources Engineering, College of Engineering, Peking University, Beijing 100871,China (China); Li, Huibo, E-mail: hb0012@sina.com [China Institute of Atomic Energy, P.O. Box 275-26, Beijing 102413 (China)

    2017-02-15

    Highlights: • Two Re adsorbents were synthesized by grafting of vinylimidazole and vinylpyridine onto silanized silica gel via γ-radiation. • The Re adsorption capacities of SS-MPTS-VIMH and SS-MPTS-VPQ were 145.99 mg g{sup −1} and 71.08 mg g{sup −1}, respectively. • Both the adsorbents had fast adsorption kinetics, and could be used for column adsorption. • SS-MPTS-VPQ had good anti-interference abilities, and might be used for the disposal of Tc in the future. - Abstract: Two silica gel based adsorbents for Re (VII), i.e. SS-MPTS-VIMH and SS-MPTS-VPQ, were synthesised. Silica gel was used as the matrix for γ-radiation grafting, and the monomer of 1-vinyl imidazole (VIM) and 4-vinylpyridine (4-VP) was grafted onto the silica silanized by methacryloxy propyl trimethoxyl silane, respectively. A VIM concentration of 2 mol L{sup −1} and an absorbed dose of 30 kGy were the optimal grafting conditions for adsorbent SS-MPTS-VIM, and a 4-VP concentration of 4 mol L{sup −1} and an absorbed dose of 40 kGy were the optimal grafting conditions for adsorbent SS-MPTS-VP. At the certain condition, the grafting yield of SS-MPTS-VIM was 30.1% and that of SS-MPTS-VP was 21.0%. The adsorption capacity of adsorbent SS-MPTS-VIMH was 145.99 mg g{sup −1} and that of SS-MPTS-VPQ was 71.08 mg g{sup −1} according to the Langmuir model. The adsorbent SS-MPTS-VPQ had better adsorption properties of acid resistance and anti-interference than SS-MPTS-VIMH. Dynamic column experiments showed that protonated adsorbent SS-MTPS-VIMH could be recycled with good performance while quaternized adsorbent SS-MPTS-VPQ could not. The adsorbent SS-MPTS-VIMH belongs to weak anion exchange adsorbent and SS-MPTS-VPQ belongs to strong anion exchange adsorbent. This study paves a way to the synthesis and application of a novel silica base adsorbents for Re (VII).

  18. THE CLUSTER AGES EXPERIMENT (CASE). VII. ANALYSIS OF TWO ECLIPSING BINARIES IN THE GLOBULAR CLUSTER NGC 6362

    Energy Technology Data Exchange (ETDEWEB)

    Kaluzny, J.; Rozyczka, M.; Schwarzenberg-Czerny, A.; Mazur, B. [Nicolaus Copernicus Astronomical Center, Bartycka 18, 00-716 Warsaw (Poland); Thompson, I. B. [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101-1292 (United States); Dotter, A. [Research School of Astronomy and Astrophysics, Australian National University Canberra (Australia); Burley, G. S. [Herzberg Institute of Astrophysics, National Research Council of Canada, 5071 West Saanich Road, Victoria, BC V9E 2E7 (Canada); Rucinski, S. M., E-mail: mnr@camk.edu.pl, E-mail: alex@camk.edu.pl, E-mail: batka@camk.edu.pl, E-mail: ian@obs.carnegiescience.edu, E-mail: aaron.dotter@gmail.com, E-mail: greg.burley@gmail.com, E-mail: rucinski@astro.utoronto.ca [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada)

    2015-11-15

    We use photometric and spectroscopic observations of the detached eclipsing binaries V40 and V41 in the globular cluster NGC 6362 to derive masses, radii, and luminosities of the component stars. The orbital periods of these systems are 5.30 and 17.89 days, respectively. The measured masses of the primary and secondary components (M{sub p}, M{sub s}) are (0.8337 ± 0.0063, 0.7947 ± 0.0048) M{sub ⊙} for V40 and (0.8215 ± 0.0058, 0.7280 ± 0.0047) M{sub ⊙} for V41. The measured radii (R{sub p}, R{sub s}) are (1.3253 ± 0.0075, 0.997 ± 0.013) R{sub ⊙} for V40 and (1.0739 ± 0.0048, 0.7307 ± 0.0046) R{sub ⊙} for V41. Based on the derived luminosities, we find that the distance modulus of the cluster is 14.74 ± 0.04 mag—in good agreement with 14.72 mag obtained from color–magnitude diagram (CMD) fitting. We compare the absolute parameters of component stars with theoretical isochrones in mass–radius and mass–luminosity diagrams. For assumed abundances [Fe/H] = −1.07, [α/Fe] = 0.4, and Y = 0.25 we find the most probable age of V40 to be 11.7 ± 0.2 Gyr, compatible with the age of the cluster derived from CMD fitting (12.5 ± 0.5 Gyr). V41 seems to be markedly younger than V40. If independently confirmed, this result will suggest that V41 belongs to the younger of the two stellar populations recently discovered in NGC 6362. The orbits of both systems are eccentric. Given the orbital period and age of V40, its orbit should have been tidally circularized some ∼7 Gyr ago. The observed eccentricity is most likely the result of a relatively recent close stellar encounter.

  19. Impact on postoperative bleeding and cost of recombinant activated factor VII in patients undergoing heart transplantation

    Directory of Open Access Journals (Sweden)

    Allison L Hollis

    2016-01-01

    Full Text Available Background: Cardiac transplantation can be complicated by refractory hemorrhage particularly in cases where explantation of a ventricular assist device is necessary. Recombinant activated factor VII (rFVIIa has been used to treat refractory bleeding in cardiac surgery patients, but little information is available on its efficacy or cost in heart transplant patients. Methods: Patients who had orthotopic heart transplantation between January 2009 and December 2014 at a single center were reviewed. Postoperative bleeding and the total costs of hemostatic therapies were compared between patients who received rFVIIa and those who did not. Propensity scores were created and used to control for the likelihood of receiving rFVIIa in order to reduce bias in our risk estimates. Results: Seventy-six patients underwent heart transplantation during the study period. Twenty-one patients (27.6% received rFVIIa for refractory intraoperative bleeding. There was no difference in postoperative red blood cell transfusion, chest tube output, or surgical re-exploration between patients who received rFVIIa and those who did not, even after adjusting with the propensity score (P = 0.94, P = 0.60, and P = 0.10, respectively. The total cost for hemostatic therapies was significantly higher in the rFVIIa group (median $10,819 vs. $1,985; P < 0.0001. Subgroup analysis of patients who underwent redo-sternotomy with left ventricular assist device explantation did not show any benefit for rFVIIa either. Conclusions: In this relatively small cohort, rFVIIa use was not associated with decreased postoperative bleeding in patients undergoing heart transplantation; however, it led to significantly higher cost.

  20. Mutagenesis in sequence encoding of human factor VII for gene therapy of hemophilia

    Directory of Open Access Journals (Sweden)

    B Kazemi

    2009-12-01

    Full Text Available "nBackground: Current treatment of hemophilia which is one of the most common bleeding disorders, involves replacement therapy using concentrates of FVIII and FIX .However, these concentrates have been associated with viral infections and thromboembolic complications and development of antibodies. "nThe use of recombinant human factor VII (rhFVII is effective  for the treatment of patients with  hemophilia A or B, who develop antibodies ( referred as inhibitors against  replacement therapy , because it induces coagulation independent of FVIII and FIX. However, its short half-life and high cost have limited its use. One potential solution to this problem may be the use of FVIIa gene transfer, which would attain continuing therapeutic levels of expression from a single injection. The aim of this study was to engineer a novel hFVII (human FVII gene containing a cleavage site for the intracellular protease and furin, by PCR mutagenesis "nMethods: The sequence encoding light and heavy chains of hFVII, were amplified by using hFVII/pTZ57R and specific primers, separately. The PCR products were cloned in pTZ57R vector. "nResults and discussion: Cloning was confirmed by restriction analysis or PCR amplification using specific primers and plasmid universal primers. Mutagenesis of sequence encoding light and heavy chain was confirmed by restriction enzyme. "nConclusion: In the present study, it was provided recombinant plasmids based on mutant form of DNA encoding light and heavy chains.  Joining mutant form of DNA encoding light chain with mutant heavy chain led to a new variant of hFVII. This variant can be activated by furin and an increase in the proportion of activated form of FVII. This mutant form of hFVII may be used for gene therapy of hemophilia.

  1. PENGEMBANGAN INSTRUMEN ASESMEN MENULIS KREATIF CERITA FANTASI UNTUK SISWA KELAS VII SMP

    Directory of Open Access Journals (Sweden)

    Anggie Lestantiya Febriyanti

    2017-10-01

    hasil uji validasi pada ahli asesmen, ahli pembelajaran sastra, dan uji coba produk pada siswa kelas VII SMP.

  2. First Nustar Observations of the Bl Lac-Type Blazar Pks 2155-304: Constraints on the Jet Content and Distribution of Radiating Particles

    DEFF Research Database (Denmark)

    Madejski, G. M.; Nalewajko, K.; Madsen, K. K.

    2016-01-01

    , covering the energy range 0.5–60 keV, is best described by a model consisting of a log-parabola component with curvature β = 0.3 -0.1+0.2 and a (local) photon index 3.04 ± 0.15 at photon energy of 2 keV, and a hard power-law tail with photon index 2.2 ± 0.4. The hard X-ray tail can be smoothly joined......We report the first hard X-ray observations with NuSTAR of the BL Lac-type blazar PKS 2155-304, augmented with soft X-ray data from XMM-Newton and γ-ray data from the Fermi Large Area Telescope, obtained in 2013 April when the source was in a very low flux state. A joint NuSTAR and XMM spectrum...... to the quasi-simultaneous γ-ray spectrum by a synchrotron self-Compton component produced by an electron distribution with index p = 2.2. Assuming that the power-law electron distribution extends down to γ min = 1 and that there is one proton per electron, an unrealistically high total jet power of Lp ~ 10...

  3. Magnetic anomaly patterns over crustal blocks of the King Edward VII Peninsula, Marie Byrd Land, West Antarctica

    Directory of Open Access Journals (Sweden)

    M. Spano

    2000-06-01

    Full Text Available Within the framework of the GITARA II project an aeromagnetic survey was performed during the GANOVEXVII expedition (1992/1993 over the King Edward VII Peninsula in northwestern Marie Byrd Land (West Antarctica. This region which may represent the eastern flank of the Ross Sea rift system had previously been explored only at reconnaissance level. New total field and upward continued (10 km magnetic anomaly maps are produced and interpreted here to map and discuss the crustal structure of the Edward VII Peninsula. Tworound-shaped, high-amplitude magnetic anomalies are recognised over the Alexandra Mountains block. The anomalies are difficult to interpret since susceptibility data indicate the prevalence of non-magnetic rocks at the surface. A possible interpretation is that the anomalies are due to Cretaceous mafic intrusives distinct from weakly magnetic Byrd Coast Granite of the adjacent Rockefeller Mountains block. Alternatively the anomalies could be related to buried pluton-sized Devonian Ford Granodiorite intruded by dikes. If Cretaceous in age, the former intrusives revealed from the magnetics could also be responsible for contact metamorphism of the adjacent Alexandra Mountains migmatites. Lower amplitude circular anomalies over the Central Plateau and Prestrud Inlet are likely to be caused by unexposed Devonian Ford Granodiorite which crops out in the Ford Ranges. Elongated high-frequency anomalies of the Sulzberger Bay are similar to those recognised over seismically constrained Cenozoic rift-related volcanics of the Ross Sea. A broad magnetic low over the Sulzberger Ice Shelf may be indicative of a fault bounded graben-like basin with sedimentary infill. Overall recognition of magnetic anomaly patterns and trends reveals segmentation of the Edward VII Peninsula and of the adjacent marine areas in distinct crustal blocks. Faults may separate these blocks and they are interpreted to reflect multiple Cretaceous and maybe Cenozoic crustal

  4. La 'Entrada triunfal de Fernando VII en Zaragoza', un lienzo conmemorativo de Miguel Parra (1780-1846)

    OpenAIRE

    López Terrada, María José; Alba Pagán, Ester

    2008-01-01

    El presente artículo propone una lectura del lienzo de la entrada triunfal de Fernando VII en la ciudad de Zaragoza, en su contexto histórico, atendiendo especialmente a las cambiantes circunstancias políticas del momento y a la doble función de este tipo de pintura dirigida a exaltar la imagen del monarca y obtener el favor real. Entre los años 1814 y 1818, el pintor valenciano Miguel Parra Abril (Valencia, 1780-Madrid,1846) realizó una serie de lienzos dedicada a recordar la vuelta triunfal...

  5. Thermal analysis of W VII-AS limiter system and presentation of a graphite-block concept

    International Nuclear Information System (INIS)

    Mukherjee, S.; Grigull, P.

    1989-01-01

    A 2D-finite element thermal analysis of the initial W VII-AS limiter system has been performed and is discussed. Furhter to this analysis a graphite block concept is presented. This concept has been numerically analyzed for applications as a limiter in plasma and nuclear fusion experimental devices. The results are described in this paper. This block concept seems to be also applicable to first wall and divertor designs; the graphite elements could be replaced by ceramic ones. (author). 10 refs.; 13 figs

  6. Speciation analysis of Mn(II)/Mn(VII) using Fe3O4@ionic liquids-β-cyclodextrin polymer magnetic solid phase extraction coupled with ICP-OES.

    Science.gov (United States)

    Chen, Songqing; Qin, Xingxiu; Gu, Weixi; Zhu, Xiashi

    2016-12-01

    Ionic liquids-β-cyclodextrin polymer (ILs-β-CDCP) was attached on Fe 3 O 4 nanoparticles to prepare magnetic solid phase extraction agent (Fe 3 O 4 @ILs-β-CDCP). The properties and morphology of Fe 3 O 4 @ILs-β-CDCP were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction(XRD), size distribution and magnetic analysis. A new method of magnetic solid phase extraction (MSPE) coupled to ICP-OES for the speciation of Mn(II)/Mn(VII) in water samples was established. The results showed that Mn(VII) and total manganese [Mn(II)+Mn(VII)] were quantitatively extracted after adjusting aqueous sample solution to pH 6.0 and 10.0, respectively. Mn(II) was calculated by subtraction of Mn(VII) from total manganese. Fe 3 O 4 @ILs-β-CDCP showed a higher adsorption capacity toward Mn(II) and Mn(VII). Several factors, such as the pH value, extraction temperature and sample volume, were optimized to achieve the best extraction efficiency. Moreover, the adsorption ability of Fe 3 O 4 @ILs-β-CDCP would not be significantly lower after reusing of 10 times. The accuracy of the developed method was confirmed by analyzing certified reference materials (GSB 07-1189-2000), and by spiking spring water, city water and lake water samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Honggang Wang

    2017-07-01

    Full Text Available Blockade of EGFR with reversible EGFR tyrosine kinase inhibitors (TKIs is considered the frontline strategy for advanced NSCLC with EGFR mutations. However, acquired resistance to EGFR-TKI has been observed, resulting in disease progression and limited clinical benefit. Polyphyllin VII is the main member of polyphyllin family, which has been demonstrated to show strong anticancer activity against carcinomas. The sensitizing effect and underlying mechanism of Polyphyllin VII against acquired EGFR-TKI resistant NSCLC are still unexplored. In the present study, we aim to examined the sensitizing effect of Polyphyllin VII to gefitinib by modulating P21 signaling pathway in gefitinib acquired resistant NSCLC in vitro and in vivo. Gefitinib sensitive PC-9 cells and gefitinib acquired resistant H1975 cells were used. Cell proliferation and Clonogenic assay, Cell cycle analysis, Western blotting analysis and xenograft treatment were carried out. Polyphyllin VII enhanced the anti-proliferative effects of gefitinib and gefitinib-induced G1 phase arrest by modulation of P21 signaling pathway in acquired gefitinib resistant cells in vitro and in vivo. Polyphyllin VII elevated sensitization of gefitinib acquired resistant NSCLC cells to gefitinib through G1 phase arrest and modulation of P21 signaling pathway. It provides a potential new strategy to overcome gefitinib acquired resistance for EGFR-TKI resistant NSCLC.

  8. Response matrix calculation of a Bonner Sphere Spectrometer using ENDF/B-VII libraries

    Energy Technology Data Exchange (ETDEWEB)

    Morató, Sergio; Juste, Belén; Miró, Rafael; Verdú, Gumersindo [Instituto de Seguridad Industrial, Radiofísica y Medioambiental (ISIRYM), Universitat Politècnica de València (Spain); Guardia, Vicent, E-mail: bejusvi@iqn.upv.es [GD Energy Services, Valencia (Spain). Grupo dominguis

    2017-07-01

    The present work is focused on the reconstruction of a neutron spectra using a multisphere spectrometer also called Bonner Spheres System (BSS). To that, the determination of the response detector curves is necessary therefore we have obtained the response matrix of a neutron detector by Monte Carlo (MC) simulation with MCNP6 where the use of unstructured mesh geometries is introduced as a novelty. The aim of these curves was to study the theoretical response of a widespread neutron spectrometer exposed to neutron radiation. A neutron detector device has been used in this work which is formed by a multispheres spectrometer (BSS) that uses 6 high density polyethylene spheres with different diameters. The BSS consists of a set of 0.95 g/cm{sup 3} high density polyethylene spheres. The detector is composed of a lithium iodide 6LiI cylindrical scintillator crystal 4mm x 4mm size LUDLUM Model 42 coupled to a photomultiplier tube. Thermal tables are required to include polyethylene cross section in the simulation. These data are essential to get correct and accurate results in problems involving neutron thermalization. Nowadays available literature present the response matrix calculated with ENDF.B.V cross section libraries (V.Mares et al 1993) or with ENDF.B.VI (R.Vega Carrillo et al 2007). This work uses two novelties to calculate the response matrix. On the one hand the use of unstructured meshes to simulate the geometry of the detector and the Bonner Spheres and on the other hand the use of the updated ENDF.B.VII cross sections libraries. A set of simulations have been performed to obtain the detector response matrix. 29 mono energetic neutron beams between 10 KeV to 20 MeV were used as source for each moderator sphere up to a total of 174 simulations. Each mono energetic source was defined with the same diameter as the moderating sphere used in its corresponding simulation and the spheres were uniformly irradiated from the top of the photomultiplier tube. Some

  9. CRÔNICA DE EVENTOS - VII SEMINÁRIO ANPTUR 2010

    Directory of Open Access Journals (Sweden)

    Elizabeth Kyoko Wada

    2011-05-01

    Full Text Available O VII Seminário ANPTUR 2010 foi realizado em 20 e 21 de setembro de 2010 e discutiu o tema Ética: Produção e Difusão da Pesquisa em Turismo. O objetivo principal foi o de disseminar os resultados de pesquisas concluídas ou em andamento como contribuição ao avanço do conhecimento científico do Turismo e áreas afins. Além disso, teve o propósito de reunir a comunidade científica da área para análise e discussão das questões éticas implicadas na produção e divulgação da pesquisa, para que o crescimento e consolidação acadêmica do campo do Turismo, Hospitalidade, Lazer e área afins venha acompanhado da necessária seriedade e profundidade em termos teóricos e metodológicos bem como pelo respeito para com os pares. Houve 245 participantes, sendo a maioria (62,5% de autores de trabalhos, portanto pesquisadores, mestres, doutores, docentes e/ou discentes de programas de pós-graduação stricto sensu. Todos os coordenadores dos Programas filiados à ANPTUR estavam presentes ou se fizeram representar. Estiveram representadas 75 Instituições e Entidades, de 24 Estados Brasileiros, além do Distrito Federal, bem como 8 instituições do exterior, de 7 países diferentes. A sétima edição do Seminário ANPTUR foi marcada pelo esforço de organização e estruturação do evento quanto ao seu caráter científico, a partir de um trabalho conjunto da Diretora Executiva da Associação e também de todos os seus membros efetivos e associados. Os resultados obtidos demonstram que a comunidade científica em Turismo já adota uma postura científica, crítica e reflexiva no desenvolvimento das pesquisas, as quais vêm contribuindo ao avanço do conhecimento científico e suas aplicações na realidade turística brasileira, priorizando a sustentabilidade, a responsabilidade social, a interdisciplinaridade e a ética.

  10. Sobre la supuesta presencia de una inscripción de la Legio VII Gemina (CIL II, 1126 en Lucentum (Alicante = About the supposed presence of an inscription of the Legio VII Gemina (CIL II, 1126 in Lucentum (Alicante

    Directory of Open Access Journals (Sweden)

    Antonio Manuel Poveda Navarro

    2014-12-01

    Full Text Available El objetivo de este artículo es aclarar la confusión existente en identificar por error una inscripción latina del soldado romano de la Legio VII Gemina, Lucius Valerius Nepos, con la de un supuesto hallazgo en los alrededores de la ciudad romana de Lucentum, Alicante, cuando en realidad se trata de una lápida romana de dicho personaje perteneciente a la ciudad romana de Italica, Santiponce (Sevilla. De este modo es necesario eliminar dicho documento epigráfico del listado de las inscripciones conocidas de Alicante.The aim of this article is to clarify the existing confusion in mistakenly identify a Latin inscription of a Roman soldier of the Legio VII Gemina, Lucius Valerius Nepos, with an apparent finding in the surroundings of the Roman city of Lucentum, Alicante, when in fact it is a Roman tombstone of that personage and belong to the Roman city of Italica, Santiponce (Sevilla. Thereby must be remove this epigraphic document from the list of Alicantes’s known inscriptions.

  11. Double heterozygous mutations Gln100Leu and His348Gln of the F7 gene in a patient with factor VII deficiency.

    Science.gov (United States)

    Li, Min; Zheng, Fangxiu; Jin, Yanhui; Wang, Mingshan; Zhu, Liqing; Yang, Lihong

    2013-03-01

    A 25-year-old Chinese woman who had a history of easy bruising was admitted to hospital due to uncontrolled epistaxis. She showed factor VII activity level of 2% and factor VII antigen level of 4% of the normal value. We detected a novel missense mutation g.8355 A>T (p.Gln100Leu) in the second epidermal growth factor-like (EGF) domain and a g.11482 T>G (p.His348Gln) in the catalytic domain. Although the Gln100 residue is close to the junction of EGF-2 domain with the serine protease domain, we infer that the substitution of polar negatively charged Gln residue at the position 100 with introduction of nonpolar Leu residue may be likely to perturb proper folding, resulting in decreasing factor VII activity.

  12. Multiwavelength temporal and spectral variability of the blazar OJ 287 during and after the 2015 December flare: a major accretion disc contribution

    Science.gov (United States)

    Kushwaha, Pankaj; Gupta, Alok C.; Wiita, Paul J.; Gaur, Haritma; de Gouveia Dal Pino, E. M.; Bhagwan, Jai; Kurtanidze, O. M.; Larionov, V. M.; Damljanovic, G.; Uemura, M.; Semkov, E.; Strigachev, A.; Bachev, R.; Vince, O.; Gu, Minfeng; Zhang, Z.; Abe, T.; Agarwal, A.; Borman, G. A.; Fan, J. H.; Grishina, T. S.; Hirochi, J.; Itoh, R.; Kawabata, M.; Kopatskaya, E. N.; Kurtanidze, S. O.; Larionova, E. G.; Larionova, L. V.; Mishra, A.; Morozova, D. A.; Nakaoka, T.; Nikolashvili, M. G.; Savchenko, S. S.; Troitskaya, Yu. V.; Troitsky, I. S.; Vasilyev, A. A.

    2018-01-01

    We present a multiwavelength spectral and temporal analysis of the blazar OJ 287 during its recent activity between 2015 December and 2016 May, showing strong variability in the near-infrared (NIR) to X-ray energies with detection at γ-ray energies as well. Most of the optical flux variations exhibit strong changes in polarization angle and degree. All the interband time lags are consistent with simultaneous emissions. Interestingly, on days with excellent data coverage in the NIR-UV bands, the spectral energy distributions (SEDs) show signatures of bumps in the visible-UV bands, never seen before in this source. The optical bump can be explained as accretion-disc emission associated with the primary black hole of mass ∼ 1.8 × 1010 M⊙ while the little bump feature in the optical-UV appears consistent with line emission. Further, the broad-band SEDs extracted during the first flare and during a quiescent period during this span show very different γ-ray spectra compared to previously observed flare or quiescent spectra. The probable thermal bump in the visible seems to have been clearly present since 2013 May, as found by examining all available NIR-optical observations, and favours the binary supermassive black hole model. The simultaneous multiwavelength variability and relatively weak γ-ray emission that shows a shift in the SED peak is consistent with γ-ray emission originating from inverse Compton scattering of photons from the line emission that apparently contributes to the little blue bump.

  13. Investigating the Innermost Jet Structures of Blazar S5 0716+714 Using Uniquely Dense Intra-day Photo-polarimetric Observations

    Directory of Open Access Journals (Sweden)

    Gopal Bhatta

    2016-10-01

    Full Text Available The sub-hour timescale variability commonly observed in blazars—widely known as intra-day or microvariability—has been extensively studied in optical photo-polarimetric bands over the past 25–30 years. In addition, there have been comprehensive theoretical discussions on the topic, with various models and scenarios proposed; however, the phenomenon still remains relatively poorly understood. Here we present the summary of our optical microvariability studies over the past few years based on multi-frequency photo-polarimetric Whole Earth Blazar Telescope (WEBT observation campaigns. The primary objective of the study was to explore the characteristics of the source microvariability on timescales of a few minutes to a few days using exceptionally dense photo-polarimetric observations. The results show that the source often displays fast variability with an amplitude as large as 0.3 mag within a few hours, as well as color variability on similar time scales often characterized by “bluer-when-brighter” trend. Similarly, the correlation between variability in flux and polarization appears to depend upon the configuration of the optical polarization angle relative to the positional angle of the innermost radio core of the jet. Other fascinating observations include a sudden and temporary disappearance in the observed variability lasting for ∼6 h. In addition, the modeling of individual microflares strongly suggests that the phenomenon of microvariability can be best explained by convolved emission from compact emission sites distributed stochastically in the turbulent jet. Besides, analysis of some of the well resolved micro-flares exhibiting high degrees of polarization points towards a complex magnetic geometry pervading the jet with the possible presence of small-scale regions of highly ordered and enhanced magnetic field similar to so-called “magnetic islands”.

  14. Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators.

    Science.gov (United States)

    Akocak, Suleyman; Lolak, Nabih; Vullo, Daniela; Durgun, Mustafa; Supuran, Claudiu T

    2017-12-01

    A series of 20 histamine Schiff base was synthesised by reaction of histamine, a well known carbonic anhydrase (CA, E.C 4.2.2.1.) activator pharmacophore, with substituted aldehydes. The obtained histamine Schiff bases were assayed as activators of five selected human (h) CA isozymes, the cytosolic hCA I, hCA II, and hCA VII, the membrane-anchored hCA IV and transmembrane hCA IX. Some of these compounds showed efficient activity (in the nanomolar range) against the cytosolic isoform hCA VII, which is a key CA enzyme involved in brain metabolism. Moderate activity was observed against hCA I and hCA IV (in the nanomolar to low micromolar range). The structure-activity relationship for activation of these isoforms with the new histamine Schiff bases is discussed in detail based on the nature of the aliphatic, aromatic, or heterocyclic moiety present in the aldehyde fragment of the molecule, which may participate in diverse interactions with amino acid residues at the entrance of the active site, where activators bind, and which is the most variable part among the different CA isoforms.

  15. Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease.

    Science.gov (United States)

    Lowe, Gordon D O; Rumley, Ann; McMahon, Alex D; Ford, Ian; O'Reilly, Denis St J; Packard, Christopher J

    2004-08-01

    Activated inflammation and activated blood coagulation are believed to increase the risk of coronary thrombosis and are related. We therefore compared plasma IL-6 (a key cytokine in the inflammatory process), fibrin D-dimer (a marker of fibrin turnover), and coagulation factors VII and XIIa (initiators of extrinsic and intrinsic blood coagulation, respectively) as predictors of coronary risk in the West of Scotland Coronary Prevention Study of pravastatin in men with hypercholesterolemia. 485 men who had had a coronary event (nonfatal myocardial infarction, death from coronary heart disease, or revascularization) were matched for age and smoking status with 934 controls. Baseline IL-6 and D-dimer were strong univariate predictors of coronary risk (relative risk in the highest quintile approximately twice that in the lowest quintile) and were associated with each other and with C-reactive protein. On multivariate analyses, D-dimer retained a significant association with coronary risk (relative risk, 1.86; 95% CI, 1.24 to 2.80), whereas IL-6 (1.47; 0.95 to 2.28) and C-reactive protein (1.33; 0.85 to 2.08) did not. Neither factor VII nor factor XIIa antigens were predictors of coronary events. Fibrin D-dimer may be a stronger predictor of coronary risk than inflammatory markers, perhaps through its ability to stimulate monocyte release of IL-6.

  16. Evaluation of Aryoseven Safety (Recombinant Activated Factor VII) in Patients with Bleeding Disorders (An Observational Post-Marketing Surveillance Study).

    Science.gov (United States)

    Toogeh, Gholamreza; Abolghasemi, Hassan; Eshghi, Peyman; Managhchi, Mohammadreza; Shaverdi-Niasari, Mohammadreza; Karimi, Katayoon; Roostaei, Samin; Emran, Neda; Abdollahi, Alireza

    2016-01-01

    Recombinant activated factor VII induces hemostasis in patients with coagulopathy disorders. AryoSeven™ as a safe Iranian Recombinant activated factor VII has been available on our market. This study was performed to establish the safety of AryoSeven on patients with coagulopathy disorder. This single-center, descriptive, cross sectional study was carried out in Thrombus and Homeostasis Research Center ValiAsr Hospital during 2013-2014. Fifty one patients with bleeding disorders who received at least one dose of Aryoseven were enrolled. Patients' demographic data and adverse effect of drug and reaction related to Aryoseven or previous usage of Recombinant activated FVII were recorded in questionnaires. Finally data were analyzed to compare side effects of Aryoseven and other Recombinant activated FVII brands. Aryoseven was prescribed for 51 Patients. Of all participants with mean age 57.18+21.38 yr, 31 cases were male and 26 subjects had past history of recombinant activated FVII usage. Glanzman was the most frequent disorder followed by congenital FVII deficiency, hemophilia with inhibitors, factor 5 deficiency, acquired hemophilia, hemophilia A with inhibitor, and hemophilia A or B with inhibitor. The majority of bleeding episodes had occurred in joints. Three patients (5.9%) complained about adverse effects of Aryoseven vs. 11.5 % about adverse effects of other brands. However this difference was not significant, statistically. Based on monitor patients closely for any adverse events, we concluded that Aryoseven administration under careful weighing of benefit versus potential harm may comparable with other counterpart drugs.

  17. EFEKTIVITAS PERSYARATAN HYGIENE SANITASI TERHADAP USAHA RUMAH MAKAN DAN RESTORAN BERDASARKAN KEPMENKES RI NOMOR 1098/MENKES/SK/VII/2003

    Directory of Open Access Journals (Sweden)

    Gusti Ayu Dita Nomia Sari

    2016-09-01

    Full Text Available Tourists who visited tourism destination in addition to the cultural and natural environment, food and drinks being the main attraction. Lack of awareness of the restaurant business to maintain cleanliness and sanitation are not uncommon cause of food poisoning. Legal issues raised in this study are: a How obligation of entrepreneur restaurants and legal protection for consumers under the Consumer Protection Act; b how the effectiveness of sanitation hygiene is based on Kepmenkes No. 1098 / Menkes / SK / VII / 2003 against the restaurants in the Ubud area. This study uses empirical legal research . The data is processed by analyzing qualitative descriptive analytical. Wisatawan yang mengunjungi destinasi pariwisata selain budaya dan keindahan alam, makanan dan minuman menjadi daya tarik utama lainnya. Kurangnya kesadaran pengusaha restoran untuk menjaga kebersihan dan sanitasi yang tidak jarang menyebabkan terjadinya keracunan makanan. Isu hukum yang diangkat dalam penelitian ini adalah: a Bagaimana kewajiban pelaku usaha rumah makan dan restoran dan perlindungan hukum bagi konsumen menurut UU Perlindungan Konsumen; b bagaimana efektivitas hygiene sanitasi restoran berdasarkan Kepmenkes No. 1098 / Menkes / SK / VII / 2003 terhadap rumah makan dan restoran di kawasan ubud. Penelitian ini menggunakan penelitian hukum empiris . Data diolah dengan menganalisis deskriptif kualitatif analitis.

  18. Ice VII from aqueous salt solutions: From a glass to a crystal with broken H-bonds

    Science.gov (United States)

    Klotz, S.; Komatsu, K.; Pietrucci, F.; Kagi, H.; Ludl, A.-A.; Machida, S.; Hattori, T.; Sano-Furukawa, A.; Bove, L. E.

    2016-08-01

    It has been known for decades that certain aqueous salt solutions of LiCl and LiBr readily form glasses when cooled to below ≈160 K. This fact has recently been exploited to produce a « salty » high-pressure ice form: When the glass is compressed at low temperatures to pressures higher than 4 GPa and subsequently warmed, it crystallizes into ice VII with the ionic species trapped inside the ice lattice. Here we report the extreme limit of salt incorporation into ice VII, using high pressure neutron diffraction and molecular dynamics simulations. We show that high-pressure crystallisation of aqueous solutions of LiCl•RH2O and LiBr•RH2O with R = 5.6 leads to solids with strongly expanded volume, a destruction of the hydrogen-bond network with an isotropic distribution of water-dipole moments, as well as a crystal-to-amorphous transition on decompression. This highly unusual behaviour constitutes an interesting pathway from a glass to a crystal where translational periodicity is restored but the rotational degrees of freedom remaining completely random.

  19. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials - Part II (A clinical study).

    Science.gov (United States)

    Sinha, N; Gupta, A; Logani, A; Shah, N

    2011-07-01

    To evaluate in vivo the remineralizing efficacy of silver diamine fluoride (SDF), glass ionomer Type VII (GC VII) and calcium hydroxide (Dycal). 60 subjects in the age group of 18-35 years, matching the inclusion criteria and having deep carious lesions in the permanent first and second molars were selected. The teeth were aseptically opened under rubber dam and after gross caries removal, approximately 0.4mg of soft discolored dentin was removed with a sharp spoon excavator from the mesial or distal aspect of the cavity. The test material was randomly selected and applied in a thickness of 1.5-2mm and the cavity sealed with cavit. The patients were followed up at regular intervals with radiographic evaluation at 12 weeks. At 3 months the temporary restoration was removed and dentin samples were collected from the other half of the cavity which was left in the first appointment. Atomic absorption spectrophotometry, Colorimetric test using UV-vis spectrometer and potentiometric titration were used for determining calcium, phosphorous and fluoride respectively. Almost equivalent rise in the percentage of calcium level was seen in GC VII and Ca(OH)(2) groups, followed by SDF group. Highest percentage rise in phosphate ions was seen in GC VII group followed by SDF group and Ca(OH)(2) group. Highest percentage of fluoride rise was seen in GC VII group followed by SDF group and Ca(OH)(2) group. The results indicated that both GC VII and SDF can be potential indirect pulp capping materials.

  20. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials – Part II (A clinical study)

    Science.gov (United States)

    Sinha, N; Gupta, A; Logani, A; Shah, N

    2011-01-01

    Aim: To evaluate in vivo the remineralizing efficacy of silver diamine fluoride (SDF), glass ionomer Type VII (GC VII) and calcium hydroxide (Dycal). Materials and Methods: 60 subjects in the age group of 18-35 years, matching the inclusion criteria and having deep carious lesions in the permanent first and second molars were selected. The teeth were aseptically opened under rubber dam and after gross caries removal, approximately 0.4mg of soft discolored dentin was removed with a sharp spoon excavator from the mesial or distal aspect of the cavity. The test material was randomly selected and applied in a thickness of 1.5-2mm and the cavity sealed with cavit. The patients were followed up at regular intervals with radiographic evaluation at 12 weeks. At 3 months the temporary restoration was removed and dentin samples were collected from the other half of the cavity which was left in the first appointment. Atomic absorption spectrophotometry, Colorimetric test using UV-vis spectrometer and potentiometric titration were used for determining calcium, phosphorous and fluoride respectively. Results: Almost equivalent rise in the percentage of calcium level was seen in GC VII and Ca(OH)2 groups, followed by SDF group. Highest percentage rise in phosphate ions was seen in GC VII group followed by SDF group and Ca(OH)2 group. Highest percentage of fluoride rise was seen in GC VII group followed by SDF group and Ca(OH)2 group. Conclusions: The results indicated that both GC VII and SDF can be potential indirect pulp capping materials. PMID:22025824

  1. Application of Mastering Content Services to Increase Mathematic Achievement of Student at Class VII SMP Negeri 2 Metro Year 2013/2014

    OpenAIRE

    Mahmudah, Siti

    2016-01-01

    Goals to be achieved by the researchers, is to know the results of the implementation of the mastery content services in improving student achievement of class VII SMP Negeri 2 Metro in the academic year 2013/2014. The study design using action research applied in guidance and counseling services. Subjects in this study, researchers took student class VII SMP Negeri 2 Metro in the academic year 2013/2014. Of the 24 students there are 10 students who experienced low mathematics achievement 41....

  2. As tendências atuais dos paradigmas: ciência, tecnologia e sociedade e ensino de ciências indígena no VII ENPEC

    Directory of Open Access Journals (Sweden)

    Maria Delourdes Maciel

    2014-01-01

    Full Text Available O Encontro Nacional de Pesquisas em Educação em Ciências é um evento bianual organizada pelos pesquisadores do ensino de Ciências. O objetivo principal desse encontro é reunir os professores e pesquisadores da área, para socializarem os relatos de experiência e pesquisas no ensino de Ciências. Nesse presente trabalho, foi realizado um mapeamento dos artigos apresentados nas seções de comunicação oral do VII ENPEC, somando um total de 425 artigos selecionados, procurou-se identificar os relacionados com a abordagem Ciências, Tecnologia e Sociedade (CTS no ensino de Ciências sua estrutura de organização e o numero de pesquisadores dessa área do Ensino de Ciências. Para esse estudo foi realizado uma pesquisa qualitativa de caráter bibliográfico, e para a análise dos dados buscou-se subsídios teóricos em Fiorentini (2002 e Bardin (2006 porque assim seria possível comparar minuciosamente os diferentes resultados obtidos. Conclui-se que a linha de pesquisa com a temática CTS apresentou 28 trabalhos cerca de 7% de trabalhos apresentados, confirmando uma sinalização nessa área de pesquisa pelos pesquisadores do ensino de Ciências e a temática sobre ensino de ciências indígena representou cerca de 1% dos trabalhos apresentados.

  3. Production and Testing of the VITAMIN-B7 Fine-Group and BUGLE-B7 Broad-Group Coupled Neutron/Gamma Cross-Section Libraries Derived from ENDF/B-VII.0 Nuclear Data

    Energy Technology Data Exchange (ETDEWEB)

    Risner, J. M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wiarda, D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, M. E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Miller, T. M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peplow, D. E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Patton, B. W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2011-09-30

    New coupled neutron-gamma cross-section libraries have been developed for use in light water reactor (LWR) shielding applications, including pressure vessel dosimetry calculations. The libraries, which were generated using Evaluated Nuclear Data File/B Version VII Release 0 (ENDF/B-VII.0), use the same fine-group and broad-group energy structures as the VITAMIN-B6 and BUGLE-96 libraries. The processing methodology used to generate both libraries is based on the methods used to develop VITAMIN-B6 and BUGLE-96 and is consistent with ANSI/ANS 6.1.2. The ENDF data were first processed into the fine-group pseudo-problem-independent VITAMIN-B7 library and then collapsed into the broad-group BUGLE-B7 library. The VITAMIN-B7 library contains data for 391 nuclides. This represents a significant increase compared to the VITAMIN-B6 library, which contained data for 120 nuclides. The BUGLE-B7 library contains data for the same nuclides as BUGLE-96, and maintains the same numeric IDs for those nuclides. The broad-group data includes nuclides which are infinitely dilute and group collapsed using a concrete weighting spectrum, as well as nuclides which are self-shielded and group collapsed using weighting spectra representative of important regions of LWRs. The verification and validation of the new libraries includes a set of critical benchmark experiments, a set of regression tests that are used to evaluate multigroup crosssection libraries in the SCALE code system, and three pressure vessel dosimetry benchmarks. Results of these tests confirm that the new libraries are appropriate for use in LWR shielding analyses and meet the requirements of Regulatory Guide 1.190.

  4. Far Transfer of Leadership Training: Concepts, Experiences, and Applications

    Science.gov (United States)

    2013-04-01

    psychology : the definitive statement of the Gestalt theory. New York, NY: Liveright/W.W. Norton. Kraiger, K. (2008). Transforming our models of learning...for Psychological Science Annual Convention in Chicago, IL, 26 May 2012. vii FAR TRANSFER OF LEADERSHIP TRAINING: CONCEPTS, EXPERIENCES, AND...leadership’ and ‘leader’ or, for readers familiar with popular psychological concepts, ‘emotional’ and ‘intelligence.’ Each key word was examined to

  5. Reimagining King and Country: the return of Ferdinand VII and the agony of Liberalism | Redefinir rey y soberanía: el retorno de Fernando VII y la agonía del Liberalismo

    Directory of Open Access Journals (Sweden)

    Gonzalo Butrón Prida

    2014-12-01

    Full Text Available This paper analyzes, mainly drawing on the Liberal press, the political options put forward in the early months of 1814 on the occasion of the Valençay treaty and the return of Ferdinand VII to Spain. The political atmosphere of uncertainty generated by the King’s silence allowed for the incorporation of moderate alternatives to the political debate. Thus, besides the two more popular options, associated with the 1812 Constitution and the absolute regime emerged as a result of the Mutiny of Aranjuez, it was possible to defend, regarding the monarchy, the candidacy of Carlos IV to the throne; and concerning the political system, the positive qualities of post revolutionary, moderate. Regimes were highly valued. | En este trabajo analizamos, a través principalmente de la prensa liberal, las alternativas políticas puestas en juego en los primeros meses de 1814 con motivo de la firma del tratado de Valençay y el retorno de Fernando VII a España. El clima de incertidumbre política generado por el silencio del rey permitió que, junto a las dos corrientes con más apoyos, las asociadas a la Constitución de 1812 y al régimen absoluto surgido del motín de Aranjuez, fueran contempladas alternativas intermedias, tanto con respecto a la monarquía, con la entrada en escena de la candidatura de Carlos IV al trono, como con respecto al régimen político, pues fueron ponderadas las virtudes de los regímenes templados de carácter postrevolucionario.

  6. Retsensioon : Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare. Peatoimetaja Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. 326 lk. / Mart Nutt

    Index Scriptorium Estoniae

    Nutt, Mart, 1962-

    2004-01-01

    Arvustus: Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare / peatoim. Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. - Lisatud: Ott Heinapuu tutvustav sõnum retsenseeritud väljaande kohta lk. 193. - Vt. ka: http://www.riigikogu.ee/rito/index.php?id=11357

  7. Espacio retroestíleo, punto de encuentros nerviosos: vii, ix, x, xi, xii pares craneales y el ganglio simpático cervical superior

    OpenAIRE

    Franco Castillo, Julio César; Santa María, Elsa Margarita

    2014-01-01

    Se propone una técnica para el abordaje, con fines de terapia neural, de los elementos contenidos en el espacio retroestíleo (pares craneanos VII, IX, X, XI y XII, y ganglio simpático cervical superior) que sea mínimamente invasiva y por lo tanto, presente menos riesgo de lesiones asociadas.

  8. Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis

    Science.gov (United States)

    Gasch, Philipp; Fundinger, Moritz; Müller, Jana T.; Lee, Travis; Mustroph, Angelika

    2016-01-01

    The response of Arabidopsis thaliana to low-oxygen stress (hypoxia), such as during shoot submergence or root waterlogging, includes increasing the levels of ∼50 hypoxia-responsive gene transcripts, many of which encode enzymes associated with anaerobic metabolism. Upregulation of over half of these mRNAs involves stabilization of five group VII ethylene response factor (ERF-VII) transcription factors, which are routinely degraded via the N-end rule pathway of proteolysis in an oxygen- and nitric oxide-dependent manner. Despite their importance, neither the quantitative contribution of individual ERF-VIIs nor the cis-regulatory elements they govern are well understood. Here, using single- and double-null mutants, the constitutively synthesized ERF-VIIs RELATED TO APETALA2.2 (RAP2.2) and RAP2.12 are shown to act redundantly as principle activators of hypoxia-responsive genes; constitutively expressed RAP2.3 contributes to this redundancy, whereas the hypoxia-induced HYPOXIA RESPONSIVE ERF1 (HRE1) and HRE2 play minor roles. An evolutionarily conserved 12-bp cis-regulatory motif that binds to and is sufficient for activation by RAP2.2 and RAP2.12 is identified through a comparative phylogenetic motif search, promoter dissection, yeast one-hybrid assays, and chromatin immunopurification. This motif, designated the hypoxia-responsive promoter element, is enriched in promoters of hypoxia-responsive genes in multiple species. PMID:26668304

  9. PENINGKATAN AKTIVITAS DAN HASIL BELAJAR MENGGUNAKAN METODE EKSPERIMEN PADA SISWA KELAS VII SMP NEGERI 1 PURBOLINGGO TAHUN PELAJARAN 2013/2014

    Directory of Open Access Journals (Sweden)

    Endang Kurniawati

    2014-03-01

    Full Text Available The purposeofthis studyis: to describethe use ofexperimental method sin enhancingthe activity oflearning physicsclass VII students of SMPN1Purbolinggoandto describethe use ofexperimentalmethodsin improvingstudentlearning outcomesphysicsclass VII SMP N 1 Purbolinggo.This study uses a Class Action Research and 4-cycle stages: planning, action, observation and reflection for further action. The study lasted 2 cycles each cycle consisting of 2 meetings. As the subjects in this study were VII.F grade students of SMP N 1 Purbolinggo of 40 people. Means of collecting data in the form of sheets of observations and tests. From the analysis and the results of this study concluded that the use of experimental methods in the learning process can improve the activity and student learning outcomes VII.F SMP N 1 Purbolinggo on the material and temperature measurements with an average of 11.56% increase in activity. Average learning outcomes increased by 55%. Thus it can be advisable for teachers to improve the activity and student learning outcomes using experimental methods.

  10. Dos Idiomas, Un Mundo Dual Language Project Title VII Third-Year Evaluation Report, 1997-98. Publication Number 97.21.

    Science.gov (United States)

    Liberty, Paul; Gonzalez, Rosa Maria

    An evaluation was conducted of the third year of a 5-year comprehensive bilingual education grant funded by Title VII of the Improving America's Schools Act of 1994. The grant funds a program of developmental bilingual education at two elementary schools in the Austin Independent School District (Texas). More than 25% of the students at each…

  11. Group VII Ethylene Response Factors Coordinate Oxygen and Nitric Oxide Signal Transduction and Stress Responses in Plants1

    Science.gov (United States)

    Gibbs, Daniel J.; Conde, Jorge Vicente; Berckhan, Sophie; Prasad, Geeta; Mendiondo, Guillermina M.; Holdsworth, Michael J.

    2015-01-01

    The group VII ethylene response factors (ERFVIIs) are plant-specific transcription factors that have emerged as important regulators of abiotic and biotic stress responses, in particular, low-oxygen stress. A defining feature of ERFVIIs is their conserved N-terminal domain, which renders them oxygen- and nitric oxide (NO)-dependent substrates of the N-end rule pathway of targeted proteolysis. In the presence of these gases, ERFVIIs are destabilized, whereas an absence of either permits their accumulation; ERFVIIs therefore coordinate plant homeostatic responses to oxygen availability and control a wide range of NO-mediated processes. ERFVIIs have a variety of context-specific protein and gene interaction partners, and also modulate gibberellin and abscisic acid signaling to regulate diverse developmental processes and stress responses. This update discusses recent advances in our understanding of ERFVII regulation and function, highlighting their role as central regulators of gaseous signal transduction at the interface of ethylene, oxygen, and NO signaling. PMID:25944828

  12. Penerapan Pembelajaran Drill dan Bermain Terhadap Hasil Belajar Servis Bawah Dalam Permainan Bolavoli Pada Siswa Kelas VII SMPN 2 Banyuwangi

    Directory of Open Access Journals (Sweden)

    Panji Sekar Pambudi

    2016-11-01

    Full Text Available Tujuan pada penelitian ini adalah untuk mengetahui: 1 Perbedaan pengaruh antara pendekatan pembelajaran drill dan bermain terhadap hasil belajar servis bawah dalam permainan bolavoli; 2 Efektifitas pembelajaran drill dan pembelajaran bermain terhadap hasil belajar servis bawah dalam permainan bolavoli. Sasaran penelitian ini adalah siswa kelas VII SMPN 2 Banyuwangi dan jumlah sampel yang diambil sebanyak 75 siswa yang terbagi menjadi 3 kelompok yang masing-masing kelompok terdiri dari 25 siswa. Metode dalam analisa ini menggunakan metode statistik kuantitatif deskriptif dan komparatif, sedangkan proses pengambilan data dilakukan dengan melakukan tes servis bawah bolavoli, dengan mencatat hasil nilai pre-test maupun post-test pada masing-masing kelompok. Hasil penelitian menunjukkan pengaruh pendekatan pembelajaran driil dan bermain berbeda secara signifikan, analisa Tamhane nilai Sig. = 0,019 kelompok 2 (8,92 dengan beda rata-rata sebesar 5,80

  13. Motor palsies of cranial nerves (excluding VII) after vaccination: reports to the US Vaccine Adverse Event Reporting System.

    Science.gov (United States)

    Woo, Emily Jane; Winiecki, Scott K; Ou, Alan C

    2014-01-01

    We reviewed cranial nerve palsies, other than VII, that have been reported to the US Vaccine Adverse Event Reporting System (VAERS). We examined patterns for differences in vaccine types, seriousness, age, and clinical characteristics. We identified 68 reports of cranial nerve palsies, most commonly involving the oculomotor (III), trochlear (IV), and abducens (VI) nerves. Isolated cranial nerve palsies, as well as palsies occurring as part of a broader clinical entity, were reported. Forty reports (59%) were classified as serious, suggesting that a cranial nerve palsy may sometimes be the harbinger of a broader and more ominous clinical entity, such as a stroke or encephalomyelitis. There was no conspicuous clustering of live vs. inactivated vaccines. The patient age range spanned the spectrum from infants to the elderly. Independent data may help to clarify whether, when, and to what extent the rates of cranial nerve palsies following particular vaccines may exceed background levels.

  14. Abstracts of contributions presented in the VII. International Conference on the Conservation of the Eastern Imperial Eagle, Bratislava, Slovakia, 2013

    Directory of Open Access Journals (Sweden)

    Deutschová Lucia

    2014-01-01

    Full Text Available VII. International Conference on the Conservation of the Eastern Imperial Eagle (Aquila heliaca was held on October 2-5, 201 3 in Barónka hotel in Bratislava, Slovakia and it was organised by Raptor Protection of Slovakia (RPS in cooperation with the Czech Society for Ornithology and MME/BirdLife Hungary, under the auspices of the Ministry of Environment, supported by the International Visegrad Fund. Results of 43 experts from ten countries, including three countries of Visegrad region (Slovakia, Czech Republic and Hungary were presented in 20 presentations and five posters. Six contributions are published in Slovak Raptor Journal volume 8, issue 1 (2014 as full papers, further twelve contributions are published here as conference abstracts.

  15. PET Imaging of Tissue Factor in Pancreatic Cancer Using 64Cu-Labeled Active Site-Inhibited Factor VII

    DEFF Research Database (Denmark)

    Nielsen, Carsten H; Jeppesen, Troels E; Kristensen, Lotte K

    2016-01-01

    with advanced stage, increased microvessel density, metastasis, and poor overall survival. Imaging of TF expression is of clinical relevance as a prognostic biomarker and as a companion diagnostic for TF-directed therapies currently under clinical development. Factor VII (FVII) is the natural ligand to TF....... The purpose of this study was to investigate the possibility of using active site-inhibited FVII (FVIIai) labeled with (64)Cu for PET imaging of TF expression. METHODS: FVIIai was conjugated to 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA) and labeled with (64)Cu...... ((64)Cu-NOTA-FVIIai). Longitudinal in vivo PET imaging was performed at 1, 4, 15, and 36 h after injection of (64)Cu-NOTA-FVIIai in mice with pancreatic adenocarcinomas (BxPC-3). The specificity of TF imaging with (64)Cu-NOTA-FVIIai was investigated in subcutaneous pancreatic tumor models...

  16. Complete plasmid sequence carrying type IV-like and type VII secretion systems from an atypical mycobacteria strain

    Directory of Open Access Journals (Sweden)

    Sergio Mascarenhas Morgado

    Full Text Available The genus Mycobacterium is highly diverse and ubiquitous in nature, comprehending fast- and slow-growing species with distinct impact in public health. The plasmid-mediated horizontal gene transfer represents one of the major events in bacteria evolution. Here, we report the complete sequence of a 160,489 bp circular plasmid (pCBMA213_2 from an atypical and fast-growing environmental mycobacteria. This is a unique plasmid, in comparison with the characterised mycobacteria plasmids, harboring a type IV-like and ESX-P2 type VII secretion systems. pCBMA213_2 can be further explored for evolutionary and conjugation studies as well as a tool to manipulate DNA within this bacteria genus.

  17. Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

    DEFF Research Database (Denmark)

    Tholstrup, T.; Miller, G.J.; Bysted, Anette

    2003-01-01

    . Objective: We tested the hypothesis that FVII activation would be less after consumption of saturated fatty acids than after other fatty acids. Design: The effects of 6 matching dietary test fats, rich in stearic (S), palmitic (P), palmitic + myristic (M), oleic (O), trans 18:1 (T), and linoleic (L) acid......Background: Hypertriglyceridemia may represent a procoagulant state involving disturbances to the hemostatic system. Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation......, respectively, on the postprandial lipid and hemostatic profile (after 2, 4, 6, and 8 h) were investigated in 16 young men. High-fat meals (1 g fat/kg body wt; 43% from the test fatty acid) were served in the morning on 6 separate days. Results: All fats increased FVII activation. The S fat resulted in a lower...

  18. Proceedings of VII International Symposium on Nuclear and Related Techniques. XIII Workshop on Nuclear Physics. WONP-NURT 2011

    International Nuclear Information System (INIS)

    2011-02-01

    This year the XIII Workshop on Nuclear Physics (WONP) and the VII Symposium on Nuclear and Related Techniques (NURT) are organized jointly, by Instituto Superior de Tecnologias y Ciencias Aplicadas and Centro de Aplicaciones Tecnologicas y Desarrollo Nuclear. Both events gather scientists from several countries with top research work on nuclear physics and its applications. WONP has been carried out since 1994 promoting an ever-exchanging exchange between professionals of various nuclear and applied physics fields, those related to environmental and health care. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM

  19. The link between high-fat meals and postprandial activation of blood coagulation factor VII possibly involves kallikrein

    DEFF Research Database (Denmark)

    Larsen, L F; Marckmann, P; Bladbjerg, Else-Marie

    2000-01-01

    Contrary to low-fat meals, high-fat meals are known to cause postprandial factor VII (FVII) activation, but the mechanism is unknown. To study the postprandial FVII activation in detail, 18 young men consumed in randomized order high-fat or low-fat test meals. Fasting and non-fasting blood samples...... by monocytes, factor XII or insulin in postprandial FVII activation was observed. Tissue factor pathway inhibitor and prothrombin fragment 1+2, a marker of thrombin generation, were not affected postprandially after either the high-fat or the low-fat meals. Our findings indicate that triglyceride......-rich lipoproteins activate prokallikrein postprandially, which might form an important initial event in FVII activation after consumption of high-fat meals....

  20. Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

    DEFF Research Database (Denmark)

    Tholstrup, T.; Miller, G.J.; Bysted, Anette

    2003-01-01

    Background: Hypertriglyceridemia may represent a procoagulant state involving disturbances to the hemostatic system. Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation....... Objective: We tested the hypothesis that FVII activation would be less after consumption of saturated fatty acids than after other fatty acids. Design: The effects of 6 matching dietary test fats, rich in stearic (S), palmitic (P), palmitic + myristic (M), oleic (O), trans 18:1 (T), and linoleic (L) acid......, respectively, on the postprandial lipid and hemostatic profile (after 2, 4, 6, and 8 h) were investigated in 16 young men. High-fat meals (1 g fat/kg body wt; 43% from the test fatty acid) were served in the morning on 6 separate days. Results: All fats increased FVII activation. The S fat resulted in a lower...

  1. Guidelines and Data to Support Plans for Reallocating Food during Crisis Relocation. Regional Appendix. FEMA Region VII,

    Science.gov (United States)

    1982-09-01

    distributors in Region VII, Fleming co., Safeway Stores and Nash-Finch Co., have warehouses in Nebraska. These distributors account for 38% of the food...2.000 FLEMING CO INC OKLAHOMA CITY OK 1,500 1 1,500 3 SAFEWAY STORES 6 814,500 177 4,602 SAFEWAY STORES INC KANSAS CITY MO 420,500 88 4,778 OMAHA NE...FAREWAY STORES INC BOONE IA I 0 0 0 I 0 5,000 GATEWAY FOODS OF IOWA CHEROKEE IA 1 0 0 0 1 0 5,000 M AND J R HAKES LAURENS IA 2 2 0 0 0 0 1,500 SAFEWAY

  2. KEEFEKTIFAN PEMBELAJARAN KETERAMPILAN MENULIS CERPEN DENGAN MODEL INVESTIGASI KELOMPOK DAN MODEL STAD BERDASARKAN TIPE KEPRIBADIAN PESERTA DIDIK KELAS VII

    Directory of Open Access Journals (Sweden)

    Agus Pujianto

    2015-03-01

    Full Text Available Tujuan penelitian ini adalah menguji keefektifan pembelajaran keterampilan menulis cerpen dengan model investigasi kelompok dan model STAD berdasarkan tipe kepribadian peserta didik kelas VII. Keterampilan menulis cerpen membutuhkan kreativitas dalam pelaksanaan pembelajaran. Melalui keterampilan menulis cerpen siswa dapat berkreasi untuk mengemukakan ide atau gagasan yang ingin disampaikan kepada pembaca. Ide atau gagasan juga berpengaruh terhadap hasil dalam menulis cerpen. Selain itu, pengetahuan tentang cerpen juga penting dalam pembelajaran keterampilan menulis cerpen. Siswa perlu berpikir kritis untuk memunculkan ide atau gagasan yang menarik dan untuk pemahaman mengenai unsur-unsur cerpen. Tipe kepribadian yang berbeda juga perlu membutuhkan cara pengajaran yang berbeda. Oleh karena itu, dibutuhkan model pembelajaran yang cocok. Model pembelajaran yang dipilih adalah model investigasi kelompok dan model STAD.

  3. Spectral line intensities of NeVII for non-equilibrium ionization plasma including dielectronic recombination processes

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, Izumi; Kato, Takako [National Inst. for Fusion Science, Toki, Gifu (Japan); Safronova, U.

    1999-01-01

    We have calculated the dielectronic recombination rate coefficients from Li-like Ne (Ne{sup 7+}) ions to Be-like Ne (Ne{sup 6+}) ions for selected excited states of Ne{sup 6+} ions. A collisional-radiative model (CRM) for Ne{sup 6+} ions is constructed to calculate the population density of each excited state in non-equilibrium ionization plasmas, including recombining processes. NeVII spectral line intensities and the radiative power loss are calculated with the CRM. A density effect caused by collisional excitation from the metastable state 2s2p {sup 3}P is found at an electron density of 10{sup 5} - 10{sup 17} cm{sup -3}. The collisional excitations between excited states become important at high electron temperature T{sub e} > or approx. 100 eV. (author)

  4. IMPLEMENTASI PENDEKATAN SAINTIFIK PADA PENUGASAN AKTIVITAS DI BUKU TEKS BAHASA INDONESIA KELAS VII SMP BERDASARKAN KURIKULUM 2013

    Directory of Open Access Journals (Sweden)

    Fitri Kurniasari

    2017-02-01

    Full Text Available Abstract: Scientific Approach Implementation On Task Activity In Indonesia Language Text  Book For Seventh Grade Students Based On Curriculum 2013.This research aims to: (1 know the steps of “Scientific Approach” which are reflected on the tasks based on complete steps, (2 know the steps of “Scientific Approach” which are reflected on the tasks based onthe sequence steps. The research design used in this research is content analysis. The main  instrument in this research is human instrument. The research data is collected with “simak” method with tecqnique “baca” and “catat”. The data analysis is done using distributional method with tecqnique “pemilahan” based on catagory. The research reveals two findings. First, based on the complete steps, there found complete and incomplete task step. Second, based on sequence steps, there are sequence task and not sequence task. Keyword: activity task, text book, scientific approach Abstract: Implementasi Pendekatan Saintifik Pada Penugasan Aktivitas Dibuku Teks Bahasa Indonesia Kelas VII SMP Berdasarkan Kurikulum 2013. Penelitian ini bertujuan: (1 mengetahui penggunaan langkah-langkah pendekatan saintifik yang tercermin dalam penugasan berdasarkan kelengkapan langkah, (2 mengetahui penggunaan langkah-langkah pendekatan saintifik yang tercermin dalam penugasan berdasarkan urutan langkah. Desain penelitian yang digunakan dalam penelitian ini adalah analisis konten. Instrumen utama penelitian ini adalah human instrument. Data penelitian dikumpulkan dengan metode simak dengan teknik baca dan catat. Analisis data dilakukan dengan teknik pemilahan data berdasarkan katagori tertentu. Penelitian menemukan dua hasil yang  terdapat dalam Buku Teks Bahasa Indonesia Kelas VII SMP Berdasarkan Kurikulum 2013 sebagai berikut. Pertama, berdasarkan katagori kelengkapan langkah, ditemukan adanya penugasan yang menggunakan langkah secara lengkap dan tidak lengkap. Kedua, berdasarkan katagori

  5. Un protector laminado de brazo (manica procedente del campamento de la legio VII Gemina en León

    Directory of Open Access Journals (Sweden)

    Aurrecoechea, Joaquín

    2008-12-01

    Full Text Available At the archaeological excavations carried out during 1998 in Santa Marina street, near the internal face of the Late Roman wall of Leon, an important building of the legio VII gemina fortress was discovered. It was identified as a magazine with a central courtyard, erected by this legionary unit at the end of the 1st c. AD. Inside one of the constructions a fragment of a manica or a laminated arm protector was found. This element consists of 11 overlapping plates of different sizes, four of them trapezoid and seven rectangular and of greater size. Some fragments were preserved, which could have been leather. This ensemble became deformed by crushing. This protector was abandoned around the last quarter of the 3rd c. AD in a room which was possibly a storage area and was crushed by the collapse of the roof of the building.Las excavaciones arqueológicas desarrolladas durante 1998 en un solar de la calle Santa Marina, inmediato a la cara interna de la muralla bajoimperial de León, revelaron un gran edificio perteneciente al campamento de la legio VII gemina, que ha sido identificado como un almacén con patio central, levantado a finales del siglo I d. C. En el interior de una de las estancias se encontró un fragmento de manica o protector laminado de brazo. Este elemento está constituido por 11 láminas imbricadas de distinto tamaño, cuatro trapezoidales y siete rectangulares de mayor tamaño. Se conservan algunos restos de lo que pudiera ser cuero. Este conjunto se encuentra deformado por aplastamiento. El protector fue abandonado hacia el último cuarto del siglo III d. C. en una estancia destinada posiblemente a almacenamiento y quedó aplastado por el derrumbe del techo del edificio.

  6. Phosphorescent heterobimetallic complexes involving platinum(iv) and rhenium(vii) centers connected by an unsupported μ-oxido bridge.

    Science.gov (United States)

    Molaee, Hajar; Nabavizadeh, S Masoud; Jamshidi, Mahboubeh; Vilsmeier, Max; Pfitzner, Arno; Samandar Sangari, Mozhgan

    2017-11-28

    Heterobimetallic compounds [(C^N)LMe 2 Pt(μ-O)ReO 3 ] (C^N = ppy, L = PPh 3 , 2a; C^N = ppy, L = PMePh 2 , 2b; C^N = bhq, L = PPh 3 , 2c; C^N = bhq, L = PMePh 2 , 2d) containing a discrete unsupported Pt(iv)-O-Re(vii) bridge have been synthesized through a targeted synthesis route. The compounds have been prepared by a single-pot synthesis in which the Pt(iv) precursor [PtMe 2 I(C^N)L] complexes are allowed to react easily with AgReO 4 in which the iodide ligand of the starting Pt(iv) complex is replaced by an ReO 4 - anion. In these Pt-O-Re complexes, the Pt(iv) centers have an octahedral geometry, completed by a cyclometalated bidentate ligand (C^N), two methyl groups and a phosphine ligand, while the Re(vii) centers have a tetrahedral geometry. Elemental analysis, single crystal X-ray diffraction analysis and multinuclear NMR spectroscopy are used to establish their identities. The new complexes exhibit phosphorescence emission in the solid and solution states at 298 and 77 K, which is an uncommon property of platinum complexes with an oxidation state of +4. According to DFT calculations, we found that this emission behavior in the new complexes originates from ligand centered 3 LC (C^N) character with a slight amount of metal to ligand charge transfer ( 3 MLCT). The solid-state emission data of the corresponding cycloplatinated(iv) precursor complexes [PtMe 2 I(C^N)L], 1a-1d, pointed out that the replacement of I - by an ReO 4 - anion helps enhancing the emission efficiency besides shifting the emission wavelengths.

  7. Proceedings of VII International Conference for Renewable Energy, Energy Saving and Energy Education (CIER 2011)

    International Nuclear Information System (INIS)

    2011-01-01

    In this work scientists, engineers, manufactures, investors, policy makers, energy users, businessmen and other specialists present their professional experiences and commercial samples with view to reach common objectives in a climate of friendship and solidarity. Within the conference's framework there will be multiple workshops in Renewable Energy, Energy Saving and Energy Education and related fields. CIER provides an excellent platform to share experiences and promote synergies towards the challenge of achieving a sustainable energy culture

  8. Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15-base pair insertion in the F7 gene.

    Science.gov (United States)

    Peyvandi, F; Carew, J A; Perry, D J; Hunault, M; Khanduri, U; Perkins, S J; Mannucci, P M; Bauer, K A

    2001-02-15

    A case of a novel mutation in the F7 gene that results in factor VII coagulant activity (VII:c) of less than 1% and VII antigen (VII:Ag) levels of 10% is presented. DNA analysis revealed a homozygous 15-base pair (bp) in-frame insertion-type mutation at nucleotide 10554. This insertion consisted of a duplication of residues leucine (L)213 to aspartic acid (D)217 (leucine, serine, glutamic acid, histidine, and aspartic acid), probably arising by slipped mispairing between 2 copies of a direct repeat (GCGAGCACGAC) separated by 4 bp. Molecular graphic analyses showed that the insertion is located at the surface of the catalytic domain in an exposed loop stabilized by extensive salt-bridge and hydrogen bond formation at which the calcium binding site is located. The mutation probably interferes with protein folding during VII biosynthesis and/or diminishes functional activity through the loss of calcium binding. In vitro expression studies demonstrated that the levels of VII:Ag in lysates of cells transfected with wild type VII (VIIWT) were equivalent to those with mutant type VII (VIIMT), but the level of secreted VIIMT was 5% to 10% that of VIIWT. Pulse chase studies demonstrated that VIIMT did not accumulate intracellularly, and studies with inhibitors of protein degradation showed that recombinant VIIMT was partially degraded in the pre-Golgi compartment. Accordingly, only small amounts of VIIMT with undetectable procoagulant activity were secreted into conditioned media. These results demonstrate that a combination of secretion and functional defects is the mechanism whereby this insertion causes VII deficiency.

  9. Holographic fermions at strong translational symmetry breaking: a Bianchi-VII case study

    NARCIS (Netherlands)

    Bagrov, A.A.; Kaplis, N.; Krikun, A.; Schalm, K.; Zaanen, J.

    2016-01-01

    It is presently unknown how strong lattice potentials influence the fermion spectral function of the holographic strange metals predicted by the AdS/CFT correspondence. This embodies a crucial test for the application of holography to condensed matter experiments. We show that for one particular

  10. FAKTOR-FAKTOR YANG MEMPENGARUHI KESULITAN BELAJAR IPS TERPADU KELAS VII DI SMP NEGERI 1 PLANTUNGAN KABUPATEN KENDAL

    Directory of Open Access Journals (Sweden)

    Lina Maftukhah,

    2012-10-01

    Full Text Available Kesulitan belajar dipengaruhi oleh berbagai macam faktor, baik faktor intern maupun faktor ekstern. Berdasarkan hasil observasi dari data nilai UAS IPS Terpadu sebagian besar siswa kelas VII SMP Negeri 1 Plantungan mendapat nilai rendah dan menyebabkan tidak lulus KKM. Hal ini dapat dijadikan indikasi bahwa siswa mengalami kesulitan belajar IPS Terpadu. Permasalahan yang dikaji dalam penelitian ini adalah apa saja faktor-faktor yang mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu Siswa Kelas VII dan faktor apakah yang lebih dominan mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu Siswa Kelas VII SMP Negeri 1 Plantungan Kabupaten Kendal Tahun Ajaran 2011/2012. Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu dan faktor apakah yang lebih dominan mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu. Penelitian ini dilakukan di SMP N egeri 1 Plantungan Kabupaten Kendal. Populasi penelitian ini adalah siswa kelas VII sebanyak 131 siswa. Pengambilan sampel dilakukan secara proposional claster random sampling dan didapat sampel sebanyak 100 siswa. Variabel dalam penelitian ini adalah faktor-faktor yang mempengaruhi kesulitan belajar IPS Terpadu kelas VII SMP Negeri 1 Plantungan Kabupaten Kendal. Metode pengumpulan data yang digunakan adalah metode kuesioner dan dokumentasi. Sedangkan untuk analisis data yang digunakan adalah analisis faktor dan deskriptif persentase. Berdasarkan analisis faktor terdapat 5 komponen yang akan membentuk 5 faktor baru. Adapun tingkat kesulitan belajar siswa dari 5 faktor baru berdasarkan uji Deskripsi Persentase sebagai berikut : (a kemampuan siswa 61,55%, (b kemampuan guru 66,75%, (c sarana penunjang 77,00%, (d dukungan sekolah 72,67%, (e dukungan keluarga 62,00%. Dari kelima faktor yang ada, faktor kemampuan siswa merupakan pengaruh yang paling dominan dengan koefisien varian sebesar 61,55% dengan kategori menghambat

  11. Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

    Science.gov (United States)

    Di Mauro, M.; Manconi, S.; Zechlin, H.-S.; Ajello, M.; Charles, E.; Donato, F.

    2018-04-01

    The Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (| b| > 20^\\circ ), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10‑12 ph cm‑2 s‑1. With this method, we detect a flux break at (3.5 ± 0.4) × 10‑11 ph cm‑2 s‑1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ∼10‑11 ph cm‑2 s‑1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.

  12. Penerapan Teknik Peta Kehidupan Bermedia Foto dalam Pembelajaran Penyusunan Teks Deskripsi Siswa VII-C SMPN 1 Trowulan Tahun Pelajaran 2016/2017

    Directory of Open Access Journals (Sweden)

    Ariesta Bagus Pramuwibowo

    2016-11-01

    Full Text Available Here are various virtues of learning the description text for the seventh grade students, especially students of VII-C SMPN 1 Trowulan. First, an understanding of the description text is required so that students do not consider that the same description text with the text of the report on the observation. Second, learning compose the text of fiction in the novel, the structure of the text descriptions into one filler. Therefore, preparation of the text descriptions into something that must be understood by the students of VII-C SMPN 1 Trowulan. In addition to learning the primacy of the text, there is a map technique causes life with photo media should be applied in the preparation of instructional text description. First, psychologically, individuals experiencing different events that can be captured through photos. These events may be applied to various text, one text description. Second, map the life of the photo media is one way to visualize events that never happened clearly in your mind quickly. Based on the significance and cause of the research aimed to assess the accuracy of the activities of teachers and students as well as the thoroughness of learning outcomes on student learning preparation of the text description VII-C SMPN 1 Trowulan the academic year 2016/2017. This research uses experimental research design with quantitative descriptive method. Therefore, the data presentation in the form of pemerian or breakdown with numbers as supporting data. In addition, the data in this study were collected by the teacher activity assessment sheets, assessment sheets student activities, and student learning test result sheet. The results of this study as follows. First, the activity of teacher in the preparation of the text descriptions in class VII-C SMPN 1 Trowulan very appropriate because the activity score of 87. Second, the activities of students in the preparation of the description text in class VII-C SMPN 1 Trowulan appropriate

  13. Anais da XXXIV Semana Médica, X COMA e VII Congresso de Iniciação Científica 21 a 24 de Maio de 2014 / Annals of XXXIV Medical Week, and X COMA and VII Congress of Scientific Initiation 21-24 May, 2014

    Directory of Open Access Journals (Sweden)

    Nilo César do Vale Baracho

    2014-06-01

    Full Text Available É com grande prazer e satisfação que preparamos a 34ª Semana Médica, XI Congresso Médico Acadêmico (COMA e VII Congresso de Iniciação Científica. Como de costume, o evento oferecerá diversificada programação, contando com renomados especialistas de cada área a ser abordada. Todo esse conteúdo trabalhado na forma de palestras, minicursos e mesa-redonda. Para esse ano, foram selecionados temas para as palestras e discussões tais como: transplantes de órgãos e tecidos, doenças cardiovasculares, emergências médicas e doenças hepáticas relacionadas ao uso de esteroides anabolizantes. Já para os minicursos, teremos temas como: arritmias cardíacas, neurociências/neurologia/neurocirurgia, cirurgia geral, saúde e espiritualidade, manejo da dor, novos procedimentos na área da estética e medicina fetal. Completando nossa programação científica, teremos a tradicional Seção de Temas Livres e a Seção de Apresentação dos Trabalhos de Conclusão de Curso (TCC’s. Por outro lado, a confraternização de encerramento está sendo preparada por nós, com o mesmo carinho, dedicação e zelo de sempre, assim como o Show Med e a apresentação cultural da abertura do evento. Dessa forma nós, da comissão organizadora, desejamos a todos momentos de muito aprendizado, reflexão, trocas de experiência e entretenimento.

  14. COMBINE7.1 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

    Energy Technology Data Exchange (ETDEWEB)

    Woo Y. Yoon; David W. Nigg

    2009-08-01

    COMBINE7.1 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.1 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 fine-group cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko self-shielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those self-shielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.1 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a one-dimensional, discrete

  15. COMBINE7.0 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

    Energy Technology Data Exchange (ETDEWEB)

    Woo Y. Yoon; David W. Nigg

    2008-09-01

    COMBINE7.0 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.0 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 finegroup cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko selfshielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those selfshielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.0 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a onedimensional, discrete

  16. Determinación del estado de salud bucal en pacientes discapacitados del Área VII en Cienfuegos

    Directory of Open Access Journals (Sweden)

    Ana Belkys Hernández Millán

    2014-10-01

    Full Text Available Fundamento: la discapacidad constituye una preocupación social, sin embargo, se cuenta con pocos estudios sobre el estado de salud bucal de los pacientes discapacitados. Objetivo: determinar el estado de salud bucal en pacientes discapacitados del Área VII de la provincia Cienfuegos. Métodos: se realizó un estudio descriptivo, de serie de casos, del Área VII del municipio de Cienfuegos, en el periodo de enero-diciembre de 2013. Se estudiaron 192 discapacitados que acudieron a consulta estomatológica o fueron visitados en terreno. Las variables analizadas fueron: edad, sexo, nivel de escolaridad, tipo de discapacidad, clasificación epidemiológica en cuanto al estado de salud bucal, enfermedades sistémicas, factores de riesgo a tener en cuenta para las enfermedades bucales, estado de salud bucal, periodontopatías, maloclusiones, lesiones premalignas, necesidad de prótesis total o parcial y necesidad de tratamiento en Atención Primaria o Secundaria. La información se recogió en historia clínica individual, planilla de clasificación de discapacidad. Los resultados se presentan en número y porcentaje. Resultados: el género femenino fue el más afectado, y la edad más representativa la de 35-59 años, predominaron las enfermedades crónicas degenerativas, los enfermos en la clasificación epidemiológica según estado de salud bucal, la hipertensión arterial entre las enfermedades sistémicas. Antecedentes de caries fue el factor de riesgo más relevante, resultando la gingivitis crónica edematosa, con un mayor porcentaje. Conclusiones: se determinó que la salud bucal en el grupo estudiado fue deficiente y existen dificultades por parte del Estomatólogo General Integral para tratar a estos pacientes a pesar de existir programas de atención a discapacitados.

  17. KONFLIK TANAH ULAYAT ANTARA KAMANAKAN MALAKOK VS NINIAK MAMAK SUKU TOBO DI NAGARI PADANG LAWEH, KEC. KOTO VII, KAB. SIJUNJUNG

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    Welda Ningsih

    2013-06-01

    Full Text Available Conflict of communal land between kamanakan malakok with niniak mamak in Tobo clan Nagari Padang Laweh, District Koto VII Sijunjung which in this conflict kamanakan malakok from areas Bukit Bual seeks to maintain in order to get the management rights of communal land that is the intersection of SMP 8 Nagari Padang Laweh which is the possession of niniak mamak Tobo tribe does not comply with the decision of niniak mamak. The approach used in this study is a qualitative research method and descriptive. The data collection is done by observation and in-depth interviews. Based on the results of research conducted, communal land conflicts caused by kamanakan malakok who worked and fence off communal land without the permission and niniak mamak Tobo Tribe resulting land conflict issues. While the forms of conflict resolution is performed by the deliberation and consensus between the two sides, the conflict is not resolved by the prince of the tribe resulted in the issue resolved through official institutions, namely guardian Nagari, the prince of the tribe and the latter through the police, after receiving the decision of the police. Konflik tanah ulayat antara kamanakan malakok dengan niniak mamak Suku Tobo di Nagari Padang Laweh, Kecamatan Koto VII Kabupaten Sijunjung yang mana di dalam konflik ini kamanakan malakok yang berasal dari daerah Bukit Bual berupaya mempertahankan supaya mendapatkan hak pengelolaan tanah ulayat yang ada simpang SMP 8 Nagari Padang Laweh yang merupakan kepunyaan dari niniak mamak suku Tobo dengan jalan tidak mematuhi keputusan dari niniak mamak. Pendekatan yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan tipe deskriptif. Pengumpulan data dilakukan dengan observasi dan wawancara mendalam. Berdasarkan hasil penelitian yang dilakukan, konflik tanah ulayat disebabkan oleh kamanakan malakok yang menggarap dan memagari tanah ulayat tanpa seizin dan sepengatahuan niniak mamak Suku Tobo sehingga

  18. IMPROVING STUDENTS’ ACHIEVEMENT IN SPEAKING BY USING STUDENTS TEAMS ACHIEVEMENT DIVISIONS (STAD AT GRADE VII 2 STUDENTS OF JUNIOR HIGH SCHOOL 3 PEKANBARU

    Directory of Open Access Journals (Sweden)

    Syaifullah Syaifullah

    2017-07-01

    Full Text Available This research report has a problem, purpose, method, result, and conclusion. Theproblem is the students’ low achievement in speaking. The purpose is to explain whetherSTAD can better improve students’ vocabulary mastery at the grade VII 2 students of JuniorHigh School 03 Pekanbaru and to explain the factors that influence changing of theimprovement of students’ Speaking skill by using STAD at the grade VII 2 students of JuniorHigh School 03 Pekanbaru. The method used is a classroom action research with two cyclescontaining plan, action, observation, and reflection. The result shows that students’ lowachievement in speaking can be improved. Finally, the conclusion is that using STAD canbetter improve students’ achievement in speaking.Key words: Speaking skill, Students Team Achievement Division (STAD

  19. Strategi WOW (Wide Open Wonder Untuk Meningkatkan Keaktifan dan Prestasi Matematika Siswa (Penelitian Tindakan Kelas pada Siswa Kelas VII C SMPN 4 Geyer Grobogan pada 2014/2015

    Directory of Open Access Journals (Sweden)

    Ali Rohmad

    2016-06-01

    Full Text Available Penelitian ini dilatarbelakangi oleh masih rendahnya partisipasi keaktifan dan prestasi siswa kelas VII C SMP Negeri 4 Geyer Grobogan Jawa Tengah dalam pembelajaran matematika. Hal tersebut berdasarkan studi awal yang menemukan bahwa siswa yang aktif baru 23,57% dari keseluruhan siswa dan rata-rata prestasi matematika hanya 66,07. Dengan menerapkan penelitian tindakan kelas dan dengan menggunakan strategi Wide Open Wonder (WOW berhasil meningkatkan keaktifan dan prestasi matematika siswa. Penelitian ini dilaksanakan pada tahun pelajaran 2014/2015 terhadap 28 siswa kelas VII C SMP Negeri 4 Geyer Grobogan Jawa Tengah yang terlaksana sebanyak 2 siklus. Adapun teknik pengumpulan data dilakukan dengan observasi dan tes. Keberhasilan penelitian ini yaitu dapat meningkatkan keaktifan siswa hingga mencapai 58,57% dan meningkatkan rata-rata nilai prestasi matematika mencapai 75,36 serta sebanyak 85,71% siswa telah berhasil melampaui kriteria ketuntasan minimal (KKM.

  20. The Impact of Potassium Manganate (VII) on the Effectiveness of Coagulation in the Removal of Iron and Manganese from Groundwater with an Increased Content of Organic Substances

    Science.gov (United States)

    Krupińska, Izabela

    2017-12-01

    The article presents the results of studies concerning the impact of the method of Fe(II) ion oxidisation (dissolved oxygen and potassium manganate (VII)) on the effectiveness of coagulation in the removal of iron and manganese from groundwater with an increased content of organic substances. The efficiencies of two coagulants were compared: aluminium sulphate (VI) and polyaluminium chloride (Flokor 1.2A). Among the used methods of iron (II) oxidisation, the best effects have been achieved by potassium manganate (VII) because one of the oxidation products was manganese oxide (IV) precipitating from water. Better results in purifying the water were obtained with the use of a prehydrolysed coagulant Flokor 1.2 A than aluminium sulphate (VI).