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Sample records for experiments measuring glycine

  1. Glycine

    DEFF Research Database (Denmark)

    Sabin, John R.; Oddershede, Jens; Sauer, Stephan P. A.

    2013-01-01

    various aspects of the theoretical evaluation of the properties of energy deposition associated with the collision of fast ions with glycine and its zwitterions, including differences due to molecular conformation and orientation with respect to the ion beam direction as well as due to the effect...... of surrounding water molecules and the state of target aggregation.    Quantum mechanical calculations, which yield the dipole oscillator strength distribution of glycine are reported. The ease with which energy is absorbed from a fast ion, described by the mean excitation energy and stopping power of glycine...

  2. Final report of CCQM-K130 nitrogen mass fraction measurements in glycine

    Science.gov (United States)

    Medvedevskikh, Maria; Krasheninina, Maria; do Rego, Eliane C. P.; Wollinger, Wagner; Monteiro, Tânia M.; de Carvalho, Lucas J.; Acco Garcia, Steve Ali; Haraldsson, Conny; Rodriguez, M. Alejandra; Rodriguez, Gabriela; Salvo, Karino; Gavrilkin, Vladimir; Kulyk, Sergij; Samuel, Laly

    2017-01-01

    CCQM key comparison K-130 in the field of nitrogen mass fracton has been performed by the Inorganic Analysis Working Group (IAWG) of the Consultative Committee for Amount of Substance (CCQM). The aim of this key comparison CCQM-K130 is to support National Measurement Institutes (NMIs) and Designated Institutes (DIs) to demonstrate the validity of the procedures the employed for determination of nitrogen mass fraction in glycine. Mass fraction of nitrogen is very important pointer because the results of these measurements are often used for determination of protein mass fraction that is an important indicator of the quality of the vast majority of food products and raw materials, in particular dry milk powder. Proteins-enzymes catalyze chemical reactions, protein along with fats and carbohydrates is one of the indicators characterizing the energy value of food, so its definition is mandatory for all food products. The study material for this key comparison has been selected to be representative as one of the aminoacid - the simplest part of the protein. Glycine is an amino acid, single acid that does not have any isomers (melting point -290 °C specific heat of evaporation - 528,6 J/kg; specific melting heat - 981,1 J/kg; pKa - 2, 34, molar mass - 75,07 g/mol, density - 1,607 g/cm3). Ural Scientific Research Institute for Metrology (UNIIM) acted as the coordinating laboratory of this comparison. Nine NMIs participated in this key comparison and one NMI participated in Pilot study that was condacted in parallel. Report A contains the results of key comparison and pilot study. The results of Pilot study were excluded from the Report B Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM

  3. STABILITY OF EXTRATERRESTRIAL GLYCINE UNDER ENERGETIC PARTICLE RADIATION ESTIMATED FROM 2 keV ELECTRON BOMBARDMENT EXPERIMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Maté, B.; Tanarro, I.; Escribano, R.; Moreno, M. A.; Herrero, V. J. [Instituto de Estructura de la Materia (IEM-CSIC), Serrano 123, E-28006 Madrid (Spain)

    2015-06-20

    The destruction of solid glycine under irradiation with 2 keV electrons has been investigated by means of IR spectroscopy. Destruction cross sections, radiolysis yields, and half-life doses were determined for samples at 20, 40, 90, and 300 K. The thickness of the irradiated samples was kept below the estimated penetration depth of the electrons. No significant differences were obtained in the experiments below 90 K, but the destruction cross section at 300 K was larger by a factor of 2. The radiolysis yields and half-life doses are in good accordance with recent MeV proton experiments, which confirms that electrons in the keV range can be used to simulate the effects of cosmic rays if the whole sample is effectively irradiated. In the low temperature experiments, electron irradiation leads to the formation of residues. IR absorptions of these residues are assigned to the presence CO{sub 2}, CO, OCN{sup −}, and CN{sup −} and possibly to amide bands I to III. The protection of glycine by water ice is also studied. A water ice film of ∼150 nm is found to provide efficient shielding against the bombardment of 2 keV electrons. The results of this study show also that current Monte Carlo predictions provide a good global description of electron penetration depths. The lifetimes estimated in this work for various environments ranging from the diffuse interstellar medium to the inner solar system, show that the survival of hypothetical primeval glycine from the solar nebula in present solar system bodies is not very likely.

  4. Measuring the enthalpies of interaction between glycine, L-cysteine, glycylglycine, and sodium dodecyl sulfate in aqueous solutions

    Science.gov (United States)

    Badelin, V. G.; Mezhevoi, I. N.; Tyunina, E. Yu.

    2017-03-01

    Calorimetric measurements of enthalpies of solution Δsol H m for glycine, L-cysteine, and glycylglycine in aqueous solutions of sodium dodecyl sulfate (SDS) with concentrations of up to 0.05 mol kg-1 are made. Standard enthalpy of solution Δsol H 0 and enthalpy of transfer Δtr H 0 of the dipeptide from water into mixed solvent are calculated. The calculated enthalpy coefficients of paired interactions of amino acids and dipeptide with SDS prove to be positive. Hydrophobic interactions between the biomolecules and SDS are found to have a major impact on the enthalpies of interaction in the three-component systems under study, within the indicated range of concentrations.

  5. Aboveground feeding by soybean aphid, Aphis glycines, affects soybean cyst nematode, Heterodera glycines, reproduction belowground.

    Directory of Open Access Journals (Sweden)

    Michael T McCarville

    Full Text Available Heterodera glycines is a cyst nematode that causes significant lost soybean yield in the U.S. Recent studies observed the aphid Aphis glycines and H. glycines interacting via their shared host, soybean, Glycine max. A greenhouse experiment was conducted to discern the effect of A. glycines feeding on H. glycines reproduction. An H. glycines-susceptible cultivar, Kenwood 94, and a resistant cultivar, Dekalb 27-52, were grown in H. glycines-infested soil for 30 and 60 d. Ten days after planting, plants were infested with either zero, five, or ten aphids. At 30 and 60 d, the number of H. glycines females and cysts (dead females and the number of eggs within were counted. In general, H. glycines were less abundant on the resistant than the susceptible cultivar, and H. glycines abundance increased from 30 to 60 d. At 30 d, 33% more H. glycines females and eggs were produced on the resistant cultivar in the ten-aphid treatment compared to the zero-aphid treatment. However, at 30 d the susceptible cultivar had 50% fewer H. glycines females and eggs when infested with ten aphids. At 60 d, numbers of H. glycines females and cysts and numbers of eggs on the resistant cultivar were unaffected by A. glycines feeding, while numbers of both were decreased by A. glycines on the susceptible cultivar. These results indicate that A. glycines feeding improves the quality of soybean as a host for H. glycines, but at higher herbivore population densities, this effect is offset by a decrease in resource quantity.

  6. Measuring the User Experience

    Directory of Open Access Journals (Sweden)

    Harry B. Santoso

    2016-01-01

    Full Text Available The aim of the current study is to develop an adapted version of User Experience Questionnaire (UEQ and evaluate a learning management system. Although there is a growing interest on User Experience, there are still limited resources (i.e. measurement tools or questionnaires available to measure user experience of any products, especially learning management systems. Two hundreds and thirteen computer science students participated and completed the adapted version of UEQ. In the study, the researchers used a learning management system named Student Centered e-Learning Environment (SCELE. Several types of learning materials are posted in SCELE such as audio files, simulations, PowerPoint slides, multimedia contents, and webpage links. Most of the lecturers use discussion forums in their courses to encourage students to participate in active learning setting. Staff and lecturers sometimes post academic-related announcements on the SCELE homepage. Two hundred thirteen students enrolled in Computer Science program were invited to evaluate the SCELE. This study will benefit UX practitioners, HCI educators, program and center of learning resources administrators, and learning management system developers. Findings of the present study may also be valuable for universities and high schools which are using computer-based learning environments.

  7. Regulation of hepatic glycine catabolism by glucagon

    Energy Technology Data Exchange (ETDEWEB)

    Jois, M.; Hall, B.; Fewer, K.; Brosnan, J.T.

    1989-02-25

    Glucagon stimulates 14CO2 production from (1-14C) glycine by isolated rat hepatocytes. Maximal stimulation (70%) of decarboxylation of glycine by hepatocytes was achieved when the concentration of glucagon in the medium reached 10 nM; half-maximal stimulation occurred at a concentration of about 2 nM. A lag period of 10 min was observed before the stimulation could be measured. Inclusion of beta-hydroxybutyrate (10 mM) or acetoacetate (10 mM) did not affect the magnitude of stimulation suggesting that the effects of glucagon were independent of mitochondrial redox state. Glucagon did not affect either the concentration or specific activity of intracellular glycine, thus excluding the possibilities that altered concentration or specific activity of intracellular glycine contributes to the observed stimulation. The stimulation of decarboxylation of glycine by glucagon was further studied by monitoring 14CO2 production from (1-14C)glycine by mitochondria isolated from rats previously injected with glucagon. Glycine decarboxylation was significantly stimulated in the mitochondria isolated from the glucagon-injected rats. We suggest that glucagon is a major regulator of hepatic glycine metabolism through the glycine cleavage enzyme system and may be responsible for the increased hepatic glycine removal observed in animals fed high-protein diets.

  8. Remote Experiments in Resistor Measurement

    Directory of Open Access Journals (Sweden)

    Popescu Viorel

    2009-10-01

    Full Text Available The paper describes blended learningapproach to teaching resistor measurement. It is basedon “Learning by Doing” paradigm: interacticesimulation, laboratory plants, real experimentsaccessed by Web Publishing Tools under LabVIEW.Studying and experimenting access is opened for 24hours a day, 7 days a week under Moodle bookingsystem.

  9. Gravitation Astrometric Measurement Experiment (GAME)

    Science.gov (United States)

    Gai, M.; Vecchiato, A.; Ligori, S.; Riva, A.; Lattanzi, M. G.; Busonero, D.; Fienga, A.; Loreggia, D.; Crosta, M. T.

    2012-07-01

    GAME is a recent concept for a small/medium class mission aimed at Fundamental Physics tests in the Solar system, by means of an optimised instrument in the visible, based on smart combination of coronagraphy and Fizeau interferometry. The targeted precision on the γ and β parameters of the Parametrised Post-Newtonian formulation of General Relativity are respectively in the 10-7-10-8 and 10-5-10-6 range, improving by one or two orders of magnitude with respect to the expectations on current or near future experiments. Such precision is suitable to detect possible deviations from the unity value, associated to generalised Einstein models for gravitation, with potentially huge impacts on the cosmological distribution of dark matter and dark energy from a Solar system scale experiment. The measurement principle is based on the differential astrometric signature on the stellar positions, i.e. based on the spatial component of the effect rather than the temporal component as in the most recent experiments using radio link delay timing variation (Cassini). The instrument concept is based on multiple field, multiple aperture Fizeau interferometry, observing simultaneously regions close to the Solar limb (requiring the adoption of coronagraphic techniques), and others in opposition to the Sun. The diluted optics approach is selected for achieving an efficient rejection of the scattered solar radiation, while retaining an acceptable angular resolution on the science targets. The multiple field observation is aimed at cost-effective control of systematic effects through simultaneous calibration. We describe the science motivation, the proposed mission profile, the instrument concept and the expected performance.

  10. EFFECT OF PHOSPHATE ON NODULE PRIMORDIA OF SOYBEAN (Glycine max Merrill IN ACID SOILS IN RHIZOTRON EXPERIMENTS

    Directory of Open Access Journals (Sweden)

    Setiyo Hadi Waluyo

    2016-10-01

    Full Text Available To clarify whether P had a direct or indirect effect on the nodulation  process of soybean grown in acid soils from Sitiung, West Sumatra, Indonesia, a series of rhizotron experiments, with special attention given to formation of nodule primordia, was conducted at Laboratory of  Microbiology, Wageningen University in 1998-2000. It was shown that Ca and P were essential nutrients for root growth, nodule formation, and growth of soybean in the acid soils (Oxisols. Ca increased root growth, number of nodule primordia, nodules, and growth of the soybean plant. This positive effect of Ca was increased considerably by the application of P. Ca and P have a synergistic effect on biological nitrogen fixation (BNF of soybean in acid soils. Ca is important for the establishment of nodules, whilst P is essential for the development and function of the formed nodules. P increased number of nodule primordia, thus it also has an important role in the initiation of nodule formation. From this study, it can be concluded that Ca and P are the most limiting nutrients for BNF of soybean in the acid soils of Sitiung, West Sumatra, Indonesia.

  11. Defining and Measuring User Experience

    DEFF Research Database (Denmark)

    Stage, Jan

    2006-01-01

    User experience is being used to denote what a user goes through while using a computerized system. The concept has gained momentum as a means to distinguish new types of applications such as games and entertainment software from more traditional work-related applications. This paper focuses...... definition of usability to develop the notion of user experience....

  12. Measuring user experience : what's new?

    NARCIS (Netherlands)

    Cremers, A.H.M.; Smets, N.; Vermeeren, A.; Kort, J.

    2007-01-01

    This paper proposes a short overview of characteristics of different user evaluation methods and a research framework to systematically compare these different methods. Comparisons will be carried out in the context of Freeband user experience studies. Results will provide more insight into how user

  13. A Novel Glycinate-based Body Wash

    Science.gov (United States)

    Regan, Jamie; Ananthapadmanabhan, K.P.

    2013-01-01

    Objective: To assess the properties of a novel body wash containing the mild surfactant glycinate. Design: Biochemical and clinical assays. Setting: Research laboratories and clinical sites in the United States and Canada. Participants: Women 18 to 65 years of age (cleansing efficacy); male and female subjects 26 to 63 years of age with mild or moderate dryness and erythema (leg-controlled application test); subjects 5 to 65 years of age with mild-to-moderate eczema (eczema compatibility); and women 18 to 64 years of age (home use). Measurements: Assessments across studies included colorimetric dye exclusion to assess skin damage potential (corneosurfametry), efficacy of cosmetic product removal from skin, change from baseline in visual dryness, change from baseline in Eczema Area and Severity Index, and self-perceived eczema attributes and self-reported product preference. Results: The glycinate-based cleanser demonstrated mildness to skin components when evaluated in a corneosurfametry assay. Short-term use under exaggerated wash conditions in subjects with dryness scores <3 and erythema scores <2 (both on a 0-6 scale) indicated an initial reduction in visual dryness. In subjects with eczema, normal use resulted in significant improvements (p<0.05) at Week 4 compared with baseline in skin dryness (change from baseline = −0.73), rash (−0.56), itch (−0.927), tightness (−0.585), and all eczema (−0.756). The glycinate-based body wash removed 56 percent of a long-lasting cosmetic foundation from skin compared with less than 30 percent removed by two competitive products tested. The glycinate-based body wash was preferred over a competitive mild cleansing product overall. Conclusion: The patented glycinate-containing body wash demonstrated better product mildness and patient-preferred attributes and clinical benefits. PMID:23882306

  14. Techniques for measuring quality of experience

    NARCIS (Netherlands)

    Kuipers, F.; Kooij, R.E.; Vleeschauwer, D. de; Brunnström, K.

    2010-01-01

    Quality of Experience (QoE) relates to how users perceive the quality of an application. To capture such a subjective measure, either by subjective tests or via objective tools, is an art on its own. Given the importance of measuring users' satisfaction to service providers, research on QoE took

  15. Techniques for measuring quality of experience

    NARCIS (Netherlands)

    Kuipers, F.; Kooij, R.; De Vleeschauwer, D.; Brunnström, K.

    2010-01-01

    Quality of Experience (QoE) relates to how users perceive the quality of an application. To capture such a subjective measure, either by subjective tests or via objective tools, is an art on its own. Given the importance of measuring users’ satisfaction to service providers, research on QoE took

  16. Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.

    Directory of Open Access Journals (Sweden)

    Anette Ericsson

    Full Text Available The current study extends previously reported PPARα agonist WY 14,643 (30 µmol/kg/day for 4 weeks effects on circulating amino acid concentrations in rats fed a 48% saturated fat diet. Steady-state tracer experiments were used to examine in vivo kinetic mechanisms underlying altered plasma serine, glycine and arginine levels. Urinary urea and creatinine excretion were measured to assess whole-body amino acid catabolism. WY 14,643 treated animals demonstrated reduced efficiency to convert food consumed to body weight gain while liver weight was increased compared to controls. WY 14,643 raised total amino acid concentration (38%, largely explained by glycine, serine and threonine increases. 3H-glycine, 14C-serine and 14C-arginine tracer studies revealed elevated rates of appearance (Ra for glycine (45.5 ± 5.8 versus 17.4 ± 2.7 µmol/kg/min and serine (21.0 ± 1.4 versus 12.0 ± 1.0 in WY 14,643 versus control. Arginine was substantially decreased (-62% in plasma with estimated Ra reduced from 3.1 ± 0.3 to 1.2 ± 0.2 µmol/kg/min in control versus WY 14,643. Nitrogen excretion over 24 hours was unaltered. Hepatic arginase activity was substantially decreased by WY 14,643 treatment. In conclusion, PPARα agonism potently alters metabolism of several specific amino acids in the rat. The changes in circulating levels of serine, glycine and arginine reflected altered fluxes into the plasma rather than changes in clearance or catabolism. This suggests that PPARα has an important role in modulating serine, glycine and arginine de novo synthesis.

  17. Chemical-exchange-saturation-transfer magnetic resonance imaging to map gamma-aminobutyric acid, glutamate, myoinositol, glycine, and asparagine: Phantom experiments

    Science.gov (United States)

    Oh, Jang-Hoon; Kim, Hyug-Gi; Woo, Dong-Cheol; Jeong, Ha-Kyu; Lee, Soo Yeol; Jahng, Geon-Ho

    2017-03-01

    The physical and technical development of chemical-exchange-saturation-transfer (CEST) magnetic resonance imaging (MRI) using clinical 3 T MRI was explored with the goal of mapping asparagine (Asn), gamma-aminobutyric acid (GABA), glutamate (Glu), glycine (Gly), and myoinositol (MI), which exist in the brain. Phantoms with nine different conditions at concentrations of 10, 30, and 50 mM and pH values of 5.6, 6.2, and 7.4 were prepared for the five target molecules to evaluate the dependence of the CEST effect in the concentration, the pH, and the amplitude of the applied radiofrequency field B1. CEST images in the offset frequency range of ±6 parts per million (ppm) were acquired using a pulsed radio-frequency saturation scheme with a clinical 3 T MRI system. A voxel-based main magnetic field B0 inhomogeneity correction, where B0 is the center frequency offset at zero ppm, was performed by using the spline interpolation method to fit the full Z-spectrum to estimate the center frequency. A voxel-based CEST asymmetry map was calculated to evaluate amide (-NH), amine (-NH2), and hydroxyl (-OH) groups for the five target molecules. The CEST effect for Glu, GABA, and Gly clearly increased with increasing concentrations. The CEST effect for MI was minimal, with no noticeable differences at different concentrations. The CEST effect for Glu and Gly increased with increasing acidity. The highest CEST asymmetry for GABA was observed at pH 6.2. The CEST effect for Glu, GABA, and Gly increased with increasing B1 amplitude. For all target molecules, the CEST effect for the human 3 T MRI system increased with increasing concentration and B1 amplitude, but varied with pH, depending on the characteristics of the molecules. The CEST effect for MI may be not suitable with clinical MRI systems. These results show that CEST imaging in the brain with the amine protons by using 3 T MRI is possible for several neuronal diseases.

  18. Chiral Ramachandran Plots I: Glycine.

    Science.gov (United States)

    Baruch-Shpigler, Yael; Wang, Huan; Tuvi-Arad, Inbal; Avnir, David

    2017-10-24

    Ramachandran plots (RPs) map the wealth of conformations of the polypeptide backbone and are widely used to characterize protein structures. A limitation of the RPs is that they are based solely on two dihedral angles for each amino acid residue and provide therefore only a partial picture of the conformational richness of the protein. Here we extend the structural RP analysis of proteins from a two-dimensional (2D) map to a three-dimensional map by adding the quantitative degree of chirality-the continuous chirality measure (CCM)-of the amino acid residue at each point in the RP. This measure encompasses all bond angles and bond lengths of an amino acid residue. We focus in this report on glycine (Gly) because, due to its flexibility, it occupies a large portion of the 2D map, thus allowing a detailed study of the chirality measure, and in order to evaluate the justification of classically labeling Gly as the only achiral amino acid. We have analyzed in detail 4366 Gly residues extracted from high resolution crystallographic data of 160 proteins. This analysis reveals not only that Gly is practically always conformationally chiral, but that upon comparing with the backbone of all amino acids, the quantitative chirality values of Gly are of similar magnitudes to those of the (chiral) amino acids. Structural trends and energetic considerations are discussed in detail. Generally we show that adding chirality to Ramachandran plots creates far more informative plots that highlight the sensitivity of the protein structure to minor conformational changes.

  19. Top quark measurements in the CMS experiment

    CERN Document Server

    Lista, Luca

    2017-01-01

    Experimental results on top-quark physics obtained at the CMS experiment are reported based on the data recorded at centre-of-mass energy up to 13 TeV. Inclusive and differential cross sections for both top-quark pair and single top-quark production are presented, as well as measurements of top-quark properties in production and decay, and searches for anomalous couplings. The presented measurements test theoretical predictions, including recent perturbative QCD calculations, provide constraints of fundamental standard model parameters, and set limits on physics beyond the standard model.

  20. Measuring the uncertainties of discharge measurements: interlaboratory experiments in hydrometry

    Science.gov (United States)

    Le Coz, Jérôme; Blanquart, Bertrand; Pobanz, Karine; Dramais, Guillaume; Pierrefeu, Gilles; Hauet, Alexandre; Despax, Aurélien

    2015-04-01

    Quantifying the uncertainty of streamflow data is key for hydrological sciences. The conventional uncertainty analysis based on error propagation techniques is restricted by the absence of traceable discharge standards and by the weight of difficult-to-predict errors related to the operator, procedure and measurement environment. Field interlaboratory experiments recently emerged as an efficient, standardized method to 'measure' the uncertainties of a given streamgauging technique in given measurement conditions. Both uncertainty approaches are compatible and should be developed jointly in the field of hydrometry. In the recent years, several interlaboratory experiments have been reported by different hydrological services. They involved different streamgauging techniques, including acoustic profilers (ADCP), current-meters and handheld radars (SVR). Uncertainty analysis was not always their primary goal: most often, testing the proficiency and homogeneity of instruments, makes and models, procedures and operators was the original motivation. When interlaboratory experiments are processed for uncertainty analysis, once outliers have been discarded all participants are assumed to be equally skilled and to apply the same streamgauging technique in equivalent conditions. A universal requirement is that all participants simultaneously measure the same discharge, which shall be kept constant within negligible variations. To our best knowledge, we were the first to apply the interlaboratory method for computing the uncertainties of streamgauging techniques, according to the authoritative international documents (ISO standards). Several specific issues arise due to the measurements conditions in outdoor canals and rivers. The main limitation is that the best available river discharge references are usually too uncertain to quantify the bias of the streamgauging technique, i.e. the systematic errors that are common to all participants in the experiment. A reference or a

  1. Plasma temperature measurements in disruption simulated experiment

    Energy Technology Data Exchange (ETDEWEB)

    Arkhipov, N.I. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Bakhtin, V.P. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Safronov, V.M. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Toporkov, D.A. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Vasenin, S.G. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Wurz, H. [Kernforschungszentrum Karlsruhe, INR (Germany); Zhitlukhin, A.M. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation)

    1995-12-31

    Results are reported of experiments to measure the temporal and spatial distributions of a temperature and radiation of a near surface plasma cloud appearing in the disruption simulated experiments. These measurements are needed to verificate the different numerical models of vapor shielding layer which appears to arise near the divertor plates surface and prevents them from the bulk of the incoming energy. Experiments with graphite and tungsten samples were carried out at the 2MK-200 plasma facility. Long CUSP trap was used as a source of high temperature deuterium plasma with a power density W = 10 MW/cm{sup 2} and time duration t = 20 mcs. Laser scattering, space and time resolved soft x-ray spectroscopy was employed to measure the plasma cloud temperature and radiation. The different behaviour of shielding layer parameters was shown for a graphite and tungsten samples. For a tungsten the sharp boundary existed between the incoming deuterium plasma and the thin layer of ablated material plasma and the strong gradient of electron temperature took place in this zone. For a graphite this boundary was broadened at the distance and the main part of the screening layer consisted of the mixture of the incoming deuterium and ablated carbon plasma. (orig.).

  2. The Copenhagen tracer experiments: Reporting of measurements

    DEFF Research Database (Denmark)

    Gryning, Sven-Erik; Lyck, E.

    2002-01-01

    buoyancy from a tower at a height of 115 meters and then collected 2-3 meters above ground-level at positions in up to three crosswind arcs of tracer sampling units, positioned 2-6 km from the point of release. Three consecutive 20 min averaged tracer concentrations were measured, allowing for a total......This is the comprehensive data report from a series of tracer experiment carried out in the Copenhagen area in 1978/79 under neutral and unstable atmospheric conditions. The report contains sulphurhexafluoride of tracer concentrations and meteorologicalmeasurements The tracer was released without...... sampling time of 1 hour. The site was mainly residential having a roughness length of 0.6 m. The meteorological measurements performed during the experimentsincluded standard measurements along the tower of tracer release as well as the three-dimensional wind velocity fluctuations at the height of release....

  3. Intercrop performance of different varieties of soybean ( Glycine Max ...

    African Journals Online (AJOL)

    Field experiments to investigate intercrop performance of different varieties of soybean (Glycine Max. (L.) Merril) in a cassava (Manihot esculenta Crantz) based cropping system within the derived savannah zone were conducted at Nsukka Utisol in Southeast Nigeria ecological. Two varieties of cassava and six varieties of ...

  4. Growth rate measurement in free jet experiments

    Science.gov (United States)

    Charpentier, Jean-Baptiste; Renoult, Marie-Charlotte; Crumeyrolle, Olivier; Mutabazi, Innocent

    2017-07-01

    An experimental method was developed to measure the growth rate of the capillary instability for free liquid jets. The method uses a standard shadow-graph imaging technique to visualize a jet, produced by extruding a liquid through a circular orifice, and a statistical analysis of the entire jet. The analysis relies on the computation of the standard deviation of a set of jet profiles, obtained in the same experimental conditions. The principle and robustness of the method are illustrated with a set of emulated jet profiles. The method is also applied to free falling jet experiments conducted for various Weber numbers and two low-viscosity solutions: a Newtonian and a viscoelastic one. Growth rate measurements are found in good agreement with linear stability theory in the Rayleigh's regime, as expected from previous studies. In addition, the standard deviation curve is used to obtain an indirect measurement of the initial perturbation amplitude and to identify beads on a string structure on the jet. This last result serves to demonstrate the capability of the present technique to explore in the future the dynamics of viscoelastic liquid jets.

  5. Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits.

    Directory of Open Access Journals (Sweden)

    Florian Wegner

    Full Text Available BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease. While glutamate and GABA(A receptors play an important role in neurogenesis, the involvement of glycine receptors during human neurogenesis and dopaminergic differentiation as well as their molecular and functional characteristics in NPCs are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Here we investigated NPCs in respect to their glycine receptor function and subunit expression using electrophysiology, calcium imaging, immunocytochemistry, and quantitative real-time PCR. Whole-cell recordings demonstrate the ability of NPCs to express functional strychnine-sensitive glycine receptors after differentiation for 3 weeks in vitro. Pharmacological and molecular analyses indicate a predominance of glycine receptor heteromers containing α2β subunits. Intracellular calcium measurements of differentiated NPCs suggest that glycine evokes depolarisations mediated by strychnine-sensitive glycine receptors and not by D-serine-sensitive excitatory glycine receptors. Culturing NPCs with additional glycine, the glycine-receptor antagonist strychnine, or the Na(+-K(+-Cl(- co-transporter 1 (NKCC1-inhibitor bumetanide did not significantly influence cell proliferation and differentiation in vitro. CONCLUSIONS/SIGNIFICANCE: These data indicate that NPCs derived from human fetal midbrain tissue acquire essential glycine receptor properties during neuronal maturation. However, glycine receptors seem to have a limited functional impact on neurogenesis and dopaminergic differentiation of NPCs in vitro.

  6. Measuring Antineutrino Oscillations with the MINOS Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Justin John [Univ. of Oxford (United Kingdom)

    2008-09-01

    MINOS is a long baseline neutrino oscillation experiment. A manmade beam of predominantly muon neutrinos is detected both 1 km and 735 km from the production point by two functionally identical detectors. A comparison of the energy spectra measured by the two detectors shows the energy-dependent disappearance of muon neutrinos characteristic of oscillations and allows a measurement of the parameters governing the oscillations. This thesis presents work leading to measurements of disappearance in the 6% $\\bar{v}$μ background in that beam. A calibration is developed to correct for time-dependent changes in the responses of both detectors, reducing the corresponding uncertainty on hadronic energy measurements from 1.8% to 0.4% in the near detector and from 0.8% to 0.4% in the far detector. A method of selecting charged current $\\bar{v}$μ events is developed, with purities (efficiencies) of 96.5% (74.4%) at the near detector, and 98.8% (70.9%) at the far detector in the region below 10 GeV reconstructed antineutrino energy. A method of using the measured near detector neutrino energy spectrum to predict that expected at the far detector is discussed, and developed for use in the $\\bar{v}$μ analysis. Sources of systematic uncertainty contributing to the oscillation measurements are discussed. In the far detector, 32 charged current $\\bar{v}$μ events are observed below a reconstructed energy of 30 GeV, compared to an expectation of 47.8 for Δ$\\bar{m}$atm2 = Δ$\\bar{m}$atm2, sin2(2$\\bar{θ}$23) = sin2(2θ23). This deficit, in such a low-statistics sample, makes the result difficult to interpret in the context of an oscillation parameter measurement. Possible sources for the discrepancy are discussed, concluding that considerably more data are required for a definitive solution. Running MINOS with a dedicated $\\bar

  7. Crystallization of glycine with ultrasound

    DEFF Research Database (Denmark)

    Louhi-Kultanen, Marjatta; Karjalainen, Milja; Rantanen, Jukka

    2006-01-01

    Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound with an ultr......Sonocrystallization has proved to be an efficient tool to influence the external appearance and structure of a crystalline product obtained by various crystallization methods. The present work focuses on high intensity sonocrystallization of glycine by varying amplitude of ultrasound...... with an ultrasound frequency of 20kHz at two temperature ranges 40-50 and 20-30 degrees C in a jacketed 250-ml cooling crystallizer equipped with a stirrer. The polymorph composition of the obtained crystals was analyzed with a temperature variable X-ray powder diffractometer (XRPD). XRPD results showed that...... ultrasound power. This study also showed, the higher the ultrasound amplitude the smaller the crystals obtained....

  8. Antioxidant and Biological Activities of Proteinaceous Extract from Algerian Glycine max Plant.

    Science.gov (United States)

    Soussi, Nassima; Moulay, Saad; Bachari, Khaldoun; Benmiri, Yamina

    2017-01-01

    Glycine max is commonly used in Algeria for treatment of anemia deficiency and osteoporosis, it ranks first in terms of vegetal proteins. The experiment was aimed at characterizing the proteinaceous Glycine max extract and evaluating its antioxidant, biological and hematological potential. Extraction of proteinaceous materials from Glycine max plant was undertaken using water and n-hexane as extracting media. The isolation of proteins from the crude materials was done, providing the use of ammonium sulfate. The Glycine max proteins were characterized by UV-visible and FT-IR spectroscopy and analyzed by SEM micrograph and x-ray diffraction (XRD). Rheological parameters G' and G'' were assessed. The isolated proteins were tested for their antioxidant, antimicrobial and hemagglutination activities. There was a gelling effect of the protein extract which can be used as an alternative in principally made vaccines with its microbiological and antifungal activities. The proteinaceous extract from Algerian Glycine max would have a potential use in biomedical application.

  9. Glycine Cleavage Powers Photoheterotrophic Growth of Chloroflexus aurantiacus in the Absence of H 2.

    Science.gov (United States)

    He, Lian; Wang, Yaya; You, Le; Khin, Yadana; Tang, Joseph K-H; Tang, Yinjie J

    2015-01-01

    Chloroflexus aurantiacus is an anoxygenic phototrophic bacterium. Its unique CO2 fixation pathway and primitive light-harvesting antenna complexes have attracted extensive research attentions. In this work, we investigated the photoheterotrophic growth of C. aurantiacus J-10-fl using acetate [at 55°C and without H2(g)]. The results indicate that glycine can promote anaerobic biomass production in a minimal medium by threefold to fivefold. Via (13)C-metabolite analysis, we observed that glycine was involved in serine synthesis. Instead of being used as a major carbon source, glycine was degraded to produce C1 units and NAD(P)H. Tracer experiments also suggest that photoheterotrophic cultures growing with a exogenous glycine source exhibited capabilities of assimilating CO2 via multiple routes (including the 3-hydroxypropionate pathway). Finally, glycylglycine, a commonly used culture buffer, also significantly enhanced photoheterotrophic growth of C. aurantiacus, probably due to its thermal or enzymatic breakdown to glycine.

  10. Glycine cleavage powers photoheterotrophic growth of Chloroflexus aurantiacus in the absence of H2

    Directory of Open Access Journals (Sweden)

    Lian eHe

    2015-12-01

    Full Text Available Chloroflexus aurantiacus is an anoxygenic phototrophic bacterium. Its unique CO2 fixation pathway and primitive light-harvesting antenna complexes have attracted extensive research attentions. In this work, we investigated the photoheterotrophic growth of C. aurantiacus J-10-fl using acetate (at 55 oC and without H2(g. The results indicate that glycine can promote anaerobic biomass production in a minimal medium by 3~5 folds. Via 13C-metabolite analysis, we observed that glycine was involved in serine synthesis. Instead of being used as a major carbon source, glycine was degraded to produce C1 units and NAD(PH. Tracer experiments also suggest that photoheterotrophic cultures growing with a exogenous glycine source exhibited capabilities of assimilating CO2 via multiple routes (including the 3-hydroxypropionate pathway. Finally, glycylglycine, a commonly used culture buffer, could also release glycine via thermal or enzymatic degradation to significantly enhance photoheterotrophic growth of C. aurantiacus.

  11. Melanoidins extinction coefficient in the glucose/glycine Maillard reaction

    NARCIS (Netherlands)

    Martins, S.I.F.S.; Boekel, van M.A.J.S.

    2003-01-01

    Melanoidins (brown, nitrogenous polymers and co-polymers) are the final products of the Maillard reaction. The glucose/glycine melanoidins extinction coefficient was determined using C-14-labelled glucose at three different reaction conditions. The absorbance was measured at different wavelengths

  12. Fast heavy-ion radiation damage of glycine in aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Shinji [Department of Nuclear Engineering, Kyoto University, Kyoto 615-8530 (Japan); Tsuchida, Hidetsugu, E-mail: tsuchida@nucleng.kyoto-u.ac.jp [Department of Nuclear Engineering, Kyoto University, Kyoto 615-8530 (Japan); Quantum Science and Engineering Center, Kyoto University, Uji 611-0011 (Japan); Furuya, Ryosuke [Department of Nuclear Engineering, Kyoto University, Kyoto 615-8530 (Japan); Majima, Takuya; Itoh, Akio [Department of Nuclear Engineering, Kyoto University, Kyoto 615-8530 (Japan); Quantum Science and Engineering Center, Kyoto University, Uji 611-0011 (Japan)

    2016-12-15

    Fast heavy-ion radiolysis of biomolecules in aqueous solution is investigated for an atomistic understanding of radiation damage to normal cells during heavy-particle beam therapy. The smallest amino acid glycine was used as a model biomaterial. Microjets of aqueous glycine solutions under vacuum were irradiated with 4.0-MeV carbon ions corresponding to energies in the Bragg peak region. To understand the effects of the water environment on molecular damage, the yield of glycine dissociation was measured by secondary ion mass spectroscopy. The yield was significantly reduced relative to gas-phase glycine targets. This implies that the numerous water molecules surrounding a single glycine molecule act as a buffer that suppresses dissociation. This is an environmental effect similar to that observed for other biomolecular cluster targets.

  13. New organic reference materials for hydrogen, carbon, and nitrogen stable isotope-ratio measurements: caffeines, n-alkanes, fatty acid methyl esters, glycines, L-valines, polyethylenes, and oils

    Science.gov (United States)

    Schimmelmann, Arndt; Qi, Haiping; Coplen, Tyler B.; Brand, Willi A.; Fong, Jon; Meier-Augenstein, Wolfram; Kemp, Helen F.; Toman, Blaza; Ackermann, Annika; Assonov, Sergey; Aerts-Bijma, Anita; Brejcha, Ramona; Chikaraishi, Yoshito; Darwish, Tamim; Elsner, Martin; Gehre, Matthias; Geilmann, Heike; Gröning, Manfred; Hélie, Jean-François; Herrero-Martín, Sara; Meijer, Harro A.J.; Sauer, Peter E.; Sessions, Alex L.; Werner, Roland A.

    2016-01-01

    An international project developed, quality-tested, and determined isotope−δ values of 19 new organic reference materials (RMs) for hydrogen, carbon, and nitrogen stable isotope-ratio measurements, in addition to analyzing pre-existing RMs NBS 22 (oil), IAEA-CH-7 (polyethylene foil), and IAEA-600 (caffeine). These new RMs enable users to normalize measurements of samples to isotope−δ scales. The RMs span a range of δ2HVSMOW-SLAP values from −210.8 to +397.0 mUr or ‰, for δ13CVPDB-LSVEC from −40.81 to +0.49 mUr and for δ15NAir from −5.21 to +61.53 mUr. Many of the new RMs are amenable to gas and liquid chromatography. The RMs include triads of isotopically contrasting caffeines, C16 n-alkanes, n-C20-fatty acid methyl esters (FAMEs), glycines, and l-valines, together with polyethylene powder and string, one n-C17-FAME, a vacuum oil (NBS 22a) to replace NBS 22 oil, and a 2H-enriched vacuum oil. A total of 11 laboratories from 7 countries used multiple analytical approaches and instrumentation for 2-point isotopic normalization against international primary measurement standards. The use of reference waters in silver tubes allowed direct normalization of δ2H values of organic materials against isotopic reference waters following the principle of identical treatment. Bayesian statistical analysis yielded the mean values reported here. New RMs are numbered from USGS61 through USGS78, in addition to NBS 22a. Because of exchangeable hydrogen, amino acid RMs currently are recommended only for carbon- and nitrogen-isotope measurements. Some amino acids contain 13C and carbon-bound organic 2H-enrichments at different molecular sites to provide RMs for potential site-specific isotopic analysis in future studies.

  14. Microhydration of protonated glycine: an ab initio family tree.

    Science.gov (United States)

    Michaux, Catherine; Wouters, Johan; Perpète, Eric A; Jacquemin, Denis

    2008-02-28

    The incremental hydration of the glycine cation is investigated using an ab initio approach fully correcting for basis set superposition errors and explicitly incorporating electron-correlation effects. Structures with zero to four surrounding water molecules have been determined. It is demonstrated that the successive aggregates follow a Darwinian family tree, the most stable complexes systematically belonging to the same branch of the tree. In strong contrast with neutral glycine, the direct hydrogen bonding to the glycine cation is favored over bridging water structures. The agreement between experimental and theoretical hydration enthalpies and Gibbs free energies is impressive, as ab initio estimates almost systematically fit the experimental error bars. For GlyH(+)-(H2O) and GlyH(+)-(H2O)3, we show that two structures are generated by the experimental setup. The present approach also resolves most of the previous theory/experiment discrepancies and provides patterns for the evolution of the vibrational spectra: a decrease of the hydrogen-bond stretching frequency indicating second-shell water molecules. Additionally, the impact of bulk solvent solvation is investigated, as four discrete water molecules still do not fully hydrate the protonated glycine.

  15. Organic Reference Materials for Hydrogen, Carbon, and Nitrogen Stable Isotope-Ratio Measurements : Caffeines, n-Alkanes, Fatty Acid Methyl Esters, Glycines, L-Valines, Polyethylenes, and Oils

    NARCIS (Netherlands)

    Schimmelrnann, Arndt; Qi, Haiping; Coplen, Tyler B.; Brand, Willi A.; Fong, Jon; Meier-Augenstein, Wolfram; Kemp, Helen F.; Toman, Blaza; Ackermann, Annika; Assonov, Sergey; Aerts-Bijma, Anita T.; Brejcha, Ramona; Chikaraishi, Yoshito; Darwish, Tamim; Elsner, Martin; Gehre, Matthias; Geilmann, Heike; Groeing, Manfred; Helie, Jean-Francois; Herrero-Martin, Sara; Meijer, Harro A. J.; Sauer, Peter E.; Sessions, Alex L.; Werner, Roland A.

    2016-01-01

    An international project developed, quality-tested, and determined isotope-delta values of 19 new organic reference materials (RMs) for hydrogen, carbon, and nitrogen stable isotope-ratio measurements, in addition to analyzing pre-existing RMs NBS 22 (oil), IAEA-CH-7 (polyethylene foil), and

  16. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers

    Directory of Open Access Journals (Sweden)

    Makoto eBannai

    2012-04-01

    Full Text Available Approximately 30% of the general population suffers from insomnia. Given that insomnia causes many problems, amelioration of the symptoms is crucial. Recently, we found that a nonessential amino acid, glycine subjectively and objectively improves sleep quality in humans who have difficulty sleeping. We evaluated the effects of glycine on daytime sleepiness, fatigue and performances in sleep-restricted healthy subjects. Sleep was restricted to 25% less than the usual sleep time for three consecutive nights. Before bedtime, 3 g of glycine or placebo were ingested, sleepiness and fatigue were evaluated using the visual analogue scale (VAS and a questionnaire, and performance were estimated by personal computer (PC performance test program on the following day. In subjects given glycine, the VAS data showed a significant reduction in fatigue and a tendency toward reduced sleepiness. These observations were also found via the questionnaire, indicating that glycine improves daytime sleepiness and fatigue induced by acute sleep restriction. PC performance test revealed significant improvement in psychomotor vigilance test. We also measured plasma melatonin and the expression of circadian-modulated genes expression in the rat suprachiasmatic nucleus (SCN to evaluate the effects of glycine on circadian rhythms. Glycine did not show significant effects on plasma melatonin concentrations during either the dark or light period. Moreover, the expression levels of clock genes such as Bmal1 and Per2 remained unchanged. However, we observed a glycine-induced increase in the neuropeptides arginine vasopressin and vasoactive intestinal polypeptide in the light period. Although no alterations in the circadian clock itself were observed, our results indicate that glycine modulated SCN function. Thus, glycine modulates certain neuropeptides in the SCN and this phenomenon may indirectly contribute to improving the occasional sleepiness and fatigue induced by sleep

  17. Conformational Structure of Tyrosine, Tyrosyl-Glycine, and Tyrosyl-Glycyl-Glycine by Double Resonance Spectroscopy

    Science.gov (United States)

    Abo-Riziq, Ali; Grace, Louis; Crews, Bridgit; Callahan, Michael P,; van Mourik, Tanja; de Vries, Mattanjah S,

    2011-01-01

    We investigated the variation in conformation for the amino acid tyrosine (Y), alone and in the small peptides tyrosine-glycine (YC) and tyrosine-glycine-glycine (YGG), in the gas phase by using UV-UV and IR-UV double resonance spectroscopy and density functional theory calculations. For tyrosine we found seven different conformations, for YG we found four different conformations, and for YGG we found three different conformations. As the peptides get larger, we observe fewer stable conformers, despite the increasing complexity and number of degrees of freedom. We find structural trends similar to those in phenylalanine-glycine glycine (FGG) and tryptophan-glycine-glycine (WGG)j however) the effect of dispersive forces in FGG for stabilizing a folded structure is replaced by that of hydrogen bonding in YGG.

  18. Measuring enjoyment of an interactive museum experience

    NARCIS (Netherlands)

    van Dijk, Elisabeth M.A.G.; Lingnau, Andreas; Kockelkorn, Hub

    2012-01-01

    Museums are increasingly being equipped with interactive technology. The main goal of using technology is to improve the museum-going experience of visitors. In this paper, we present the results of a study with an electronic quest through a museum aimed at children in the age of 10-12. We wanted to

  19. Instrumentation, measurements, and experiments in fluids

    CERN Document Server

    Rathakrishnan, E

    2007-01-01

    NEED AND OBJECTIVE OF EXPERIMENTAL STUDY Some Fluid Mechanics MeasurementsMeasurement SystemsSome of the Important Quantities Associated with FluidFlow MeasurementsFUNDAMENTALS OF FLUID MECHANICSProperties of FluidsThermodynamic PropertiesSurface TensionAnalysis of Fluid FlowBasic and Subsidiary Laws for Continuous MediaKinematics of Fluid FlowStreamlinesPotential FlowViscous FlowsGas DynamicsWIND TUNNELSLow-Speed Wind TunnelsPower Losses in a Wind TunnelHigh-Speed Wind TunnelsHypersonic TunnelsInstrume

  20. Identification of acetyl phosphate as the product of clostridial glycine reductase: Evidence for an acyl enzyme intermediate.

    Science.gov (United States)

    Arkowitz, R A; Abeles, R H

    1989-05-30

    It has been reported [Tanaka, H., & Stadtman, T. C. (1979) J. Biol. Chem. 254, 447-452] that glycine reductase from Clostridium sticklandii catalyzes the reaction glycine + ADP + P(i) + 2(e)- - acetate + ATP + NH(4)+. Glycine reductase consists of three proteins, designated A, B, and C. Only A has been purified to homogeneity. A dithiol serves as an electron donor. We find that ADP is not essential for the reaction and that in its absence acetyl phosphate is formed. Upon further purification of components B and C, an acetate kinase activity can be separated from both proteins. This observation establishes that acetate kinase activity is not an intrinsic property of glycine reductase, and therefore the reaction catalyzed by glycine reductase is glycine + P(i) + 2(e)- - acetyl phosphate + NH(4)+. Experiments with [(14)C]glycine and unlabeled acetate show that free acetate is not a precursor of acetyl phosphate. When glycine labeled with l8(O) is converted to product, l8(O) is lost. The l 8 (O) content of unreacted glycine remains unchanged after approximately 50% is converted to product. We propose that an acyl enzyme, most probably an acetyl enzyme,is an intermediate in the reaction and that the acetyl enzyme reacts with P(i) to form acetyl phosphate. A mechanism is proposed for the formation of the acetyl enzyme.

  1. Recent Multiboson measurements with the ATLAS experiment

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    Measurements of the cross sections of the production of two electroweak gauge bosons constitute stringent tests of the electroweak sector of the Standard Model and provide a model-independent means to search for new physics at the TeV scale. We present recent ATLAS measurements of inclusive and differential cross sections for WW, WZ, ZZ and Z + photon at centre of mass energies of 8 TeV and 13 TeV. Large next-to-next-to-leading order QCD corrections were recently calculated and are confronted with the measurements. We also present recent ATLAS measurements of inclusive cross sections for electroweak production of WZ + 2 jets and production of Z + di-photon at 8 TeV. Differential distributions sensitive to anomalous triple and quartic gauge couplings have been studied and limits on new physics have been derived.

  2. Nuclear recoil measurements with the ARIS experiment

    Science.gov (United States)

    Fan, Alden; ARIS Collaboration

    2017-01-01

    As direct dark matter searches become increasingly sensitive, it is important to fully characterize the target of the search. The goal of the Argon Recoil Ionization and Scintillation (ARIS) experiment is to quantify information related to the scintillation and ionization energy scale, quenching factor, ion recombination probability, and scintillation time response of nuclear recoils, as expected from WIMPs, in liquid argon. A time projection chamber with an active mass of 0.5 kg of liquid argon and capable of full 3D position reconstruction was exposed to an inverse kinematic neutron beam at the Institut de Physique Nucleaire d'Orsay in France. A scan of nuclear recoil energies was performed through coincidence with a set of neutron detectors to quantify properties of nuclear recoils in liquid argon at various electric fields. The difference in ionization and scintillation response with differing recoil track angle to the electric field was also studied. The preliminary results of the experiment will be presented.

  3. Jet Production Measurements with the ATLAS Experiment

    CERN Document Server

    Mueller, Felix; The ATLAS collaboration

    2011-01-01

    Jet production is the hard QCD process with the widest kinematic reach and largest cross section at the LHC. Jets at large rapidity intervals, and jets which are not back-to-back, can also probe novel QCD evolution and radiation patterns. Comprehensive measurements of inclusive and dijet production are presented, as well as the production cross sections for jets containing beauty and charmed hadrons. The measurements are compared to state of-the art NLO QCD calculations, and the sensitivity to the parton distributions in the proton is also investigated.

  4. Dietary glycine blunts liver injury after bile duct ligation in rats

    Science.gov (United States)

    Froh, Matthias; Zhong, Zhi; Walbrun, Peter; Lehnert, Mark; Netter, Susanne; Wiest, Reiner; Conzelmann, Lars; Gäbele, Erwin; Hellerbrand, Claus; Schölmerich, Jürgen; Thurman, Ronald G

    2008-01-01

    AIM: To investigate the effects of (dietary) glycine against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either a diet containing 5% glycine or a standard diet was fed to male Sprague-Dawley (SD) rats. Three days later, BDL or sham-operation was performed. Rats were sacrificed 1 to 3 d after BDL. The influence of deoxycholic acid (DCA) in the presence or absence of glycine on liver cells was determined by measurement of calcium and chloride influx in cultivated Kupffer cells and lactate dehydrogenase (LDH) activity was determined in the supernatant of cultivated hepatocytes. RESULTS: Serum alanine transaminase levels increased to about 600 U/L 1 d after BDL. However, enzyme release was blunted by about two third in rats receiving glycine. Release of the alkaline phosphatase and aspartate aminotransferase was also blocked significantly in the group fed glycine. Focal necrosis was observed 2 d after BDL. Glycine partially blocked the histopathological changes. Incubation of Kupffer cells with DCA led to increased intracellular calcium that could be blocked by incubation with glycine. However, systemic blockage of Kupffer cells with gadolinium chloride had no effects on transaminase release. Incubation of isolated hepatocytes with DCA led to a significant release of LDH after 4 h. This release was largely blocked when incubation with glycine was performed. CONCLUSION: These data indicate that glycine significantly decreased liver injury, most likely by a direct effect on hepatocytes. Kupffer cells do not appear to play an important role in the pathological changes caused by cholestasis. PMID:18932277

  5. Measuring the experience of hospitality : Scale development and validation

    NARCIS (Netherlands)

    Pijls-Hoekstra, Ruth; Groen, Brenda H.; Galetzka, Mirjam; Pruyn, Adriaan T.H.

    2017-01-01

    This paper identifies what customers experience as hospitality and subsequently presents a novel and compact assessment scale for measuring customers’ experience of hospitality at any kind of service organization. The Experience of Hospitality Scale (EH-Scale) takes a broader perspective compared to

  6. Measuring Experiences of Interest-Related Pursuits in Connected Learning

    Science.gov (United States)

    Maul, Andrew; Penuel, William R.; Dadey, Nathan; Gallagher, Lawrence P.; Podkul, Timothy; Price, Emily

    2017-01-01

    This paper describes an effort to develop a survey instrument capable of measuring important aspects of adolescents' experiences of interest-related pursuits that are supported by technology. The measure focuses on youths' experiences of "connected learning" (Ito et al. in Connected learning: an agenda for research and design. Digital…

  7. Measuring the user experience collecting, analyzing, and presenting usability metrics

    CERN Document Server

    Tullis, Thomas

    2013-01-01

    Measuring the User Experience was the first book that focused on how to quantify the user experience. Now in the second edition, the authors include new material on how recent technologies have made it easier and more effective to collect a broader range of data about the user experience. As more UX and web professionals need to justify their design decisions with solid, reliable data, Measuring the User Experience provides the quantitative analysis training that these professionals need. The second edition presents new metrics such as emotional engagement, personas, k

  8. Intracellular Accumulation of Glycine in Polyphosphate-Accumulating Organisms in Activated Sludge, a Novel Storage Mechanism under Dynamic Anaerobic-Aerobic Conditions

    Science.gov (United States)

    Nguyen, Hien Thi Thu; Kristiansen, Rikke; Vestergaard, Mette; Wimmer, Reinhard

    2015-01-01

    Dynamic anaerobic-aerobic feast-famine conditions are applied to wastewater treatment plants to select polyphosphate-accumulating organisms to carry out enhanced biological phosphorus removal. Acetate is a well-known substrate to stimulate this process, and here we show that different amino acids also are suitable substrates, with glycine as the most promising. 13C-labeled glycine and nuclear magnetic resonance (NMR) were applied to investigate uptake and potential storage products when activated sludge was fed with glycine under anaerobic conditions. Glycine was consumed by the biomass, and the majority was stored intracellularly as free glycine and fermentation products. Subsequently, in the aerobic phase without addition of external substrate, the stored glycine was consumed. The uptake of glycine and oxidation of intracellular metabolites took place along with a release and uptake of orthophosphate, respectively. Fluorescence in situ hybridization combined with microautoradiography using 3H-labeled glycine revealed uncultured actinobacterial Tetrasphaera as a dominant glycine consumer. Experiments with Tetrasphaera elongata as representative of uncultured Tetrasphaera showed that under anaerobic conditions it was able to take up labeled glycine and accumulate this and other labeled metabolites to an intracellular concentration of approximately 4 mM. All components were consumed under subsequent aerobic conditions. Intracellular accumulation of amino acids seems to be a novel storage strategy for polyphosphate-accumulating bacteria under dynamic anaerobic-aerobic feast-famine conditions. PMID:25956769

  9. Glycine Polymerization on Oxide Minerals

    Science.gov (United States)

    Kitadai, Norio; Oonishi, Hiroyuki; Umemoto, Koichiro; Usui, Tomohiro; Fukushi, Keisuke; Nakashima, Satoru

    2017-06-01

    It has long been suggested that mineral surfaces played an important role in peptide bond formation on the primitive Earth. However, it remains unclear which mineral species was key to the prebiotic processes. This is because great discrepancies exist among the reported catalytic efficiencies of minerals for amino acid polymerizations, owing to mutually different experimental conditions. This study examined polymerization of glycine (Gly) on nine oxide minerals (amorphous silica, quartz, α-alumina and γ-alumina, anatase, rutile, hematite, magnetite, and forsterite) using identical preparation, heating, and analytical procedures. Results showed that a rutile surface is the most effective site for Gly polymerization in terms of both amounts and lengths of Gly polymers synthesized. The catalytic efficiency decreased as rutile > anatase > γ-alumina > forsterite > α- alumina > magnetite > hematite > quartz > amorphous silica. Based on reported molecular-level information for adsorption of Gly on these minerals, polymerization activation was inferred to have arisen from deprotonation of the NH3 + group of adsorbed Gly to the nucleophilic NH2 group, and from withdrawal of electron density from the carboxyl carbon to the surface metal ions. The orientation of adsorbed Gly on minerals is also a factor influencing the Gly reactivity. The examination of Gly-mineral interactions under identical experimental conditions has enabled the direct comparison of various minerals' catalytic efficiencies and has made discussion of polymerization mechanisms and their relative influences possible Further systematic investigations using the approach reported herein (which are expected to be fruitful) combined with future microscopic surface analyses will elucidate the role of minerals in the process of abiotic peptide bond formation.

  10. Creation of certified reference material based on glycine

    Directory of Open Access Journals (Sweden)

    M. P. Krasheninina

    2015-01-01

    Full Text Available The approaches for creating reference materials of glycine with certified values of nitrogen and base material mass fractions GSO 10272-2013 have been presented. Created certified reference material is intended for calibration and graduation of measurement equipments based on the different physical-chemical methods of analysis, as well as for check of error of measurement procedures. Besides GSO 10272-2013 can be used tor evaluating the purity of the components of medicinal preparations in pharmaceutical industry. GSO 10272-2013 will be used as an object for key comparisons in 2015.

  11. NBS (National Bureau of Standards): Materials measurements. [space processing experiments

    Science.gov (United States)

    Manning, J. R.

    1983-01-01

    Work directed toward the measurement of materials properties important to the design and interpretation of space processing experiments and determinations of how the space environment may offer a unique opportunity for performing improved measurements and producing materials with improved properties is reported. Surface tensions and their variations with temperature and impurities; convection during undirectional solidification; and measurement of the high temperature thermophysical properties of tungsten group liquids and solids are discussed and results are summarized.

  12. catena-Poly[[[aqua-(glycine-κO)lithium]-μ-glycine-κ(2) O:O'] bromide].

    Science.gov (United States)

    Balakrishnan, T; Ramamurthi, K; Jeyakanthan, J; Thamotharan, S

    2013-01-01

    In the title coordination polymer, {[Li(C2H5NO2)2(H2O)]Br} n , the Li(+) cation is coordinated by three carboxyl-ate O atoms of zwitterionic glycine mol-ecules and by a water mol-ecule, forming a distorted tetra-hedral geometry. One of the two glycine mol-ecules bridges neighbouring complexes, forming an infinite chain parallel to the c axis. Polymeric chains are further linked by extensive hydrogen bonds involving the Br(-) anions and glycine and water mol-ecules, producing a three-dimensional network.

  13. catena-Poly[[[aqua(glycine-κOlithium]-μ-glycine-κ2O:O′] bromide

    Directory of Open Access Journals (Sweden)

    T. Balakrishnan

    2013-01-01

    Full Text Available In the title coordination polymer, {[Li(C2H5NO22(H2O]Br}n, the Li+ cation is coordinated by three carboxylate O atoms of zwitterionic glycine molecules and by a water molecule, forming a distorted tetrahedral geometry. One of the two glycine molecules bridges neighbouring complexes, forming an infinite chain parallel to the c axis. Polymeric chains are further linked by extensive hydrogen bonds involving the Br− anions and glycine and water molecules, producing a three-dimensional network.

  14. 4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors

    Directory of Open Access Journals (Sweden)

    de la Roche Jeanne

    2012-09-01

    Full Text Available Abstract Background The mammalian neurological disorder hereditary hyperekplexia can be attributed to various mutations of strychnine sensitive glycine receptors. The clinical symptoms of “startle disease” predominantly occur in the newborn leading to convulsive hypertonia and an exaggerated startle response to unexpected mild stimuli. Amongst others, point mutations R271Q and R271L in the α1-subunit of strychnine sensitive glycine receptors show reduced glycine sensitivity and cause the clinical symptoms of hyperekplexia. Halogenation has been shown to be a crucial structural determinant for the potency of a phenolic compound to positively modulate glycine receptor function. The aim of this in vitro study was to characterize the effects of 4-chloropropofol (4-chloro-2,6-dimethylphenol at four glycine receptor mutations. Methods Glycine receptor subunits were expressed in HEK 293 cells and experiments were performed using the whole-cell patch-clamp technique. Results 4-chloropropofol exerted a positive allosteric modulatory effect in a low sub-nanomolar concentration range at the wild type receptor (EC50 value of 0.08 ± 0.02 nM and in a micromolar concentration range at the mutations (1.3 ± 0.6 μM, 0.1 ± 0.2 μM, 6.0 ± 2.3 μM and 55 ± 28 μM for R271Q, L, K and S267I, respectively. Conclusions 4-chloropropofol might be an effective compound for the activation of mutated glycine receptors in experimental models of startle disease.

  15. Measurement of Poloidal Velocity on the National Spherical Torus Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Ronald E. Bell and Russell Feder

    2010-06-04

    A diagnostic suite has been developed to measure impurity poloidal flow using charge exchange recombination spectroscopy on the National Spherical Torus Experiment. Toroidal and poloidal viewing systems measure all quantities required to determine the radial electric field. Two sets of up/down symmetric poloidal views are used to measure both active emission in the plane of the neutral heating beams and background emission in a radial plane away from the neutral beams. Differential velocity measurements isolate the line-integrated poloidal velocity from apparent flows due to the energy-dependent chargeexchange cross section. Six f/1.8 spectrometers measure 276 spectra to obtain 75 active and 63 background channels every 10 ms. Local measurements from a similar midplane toroidal viewing system are mapped into two dimensions to allow the inversion of poloidal line-integrated measurements to obtain local poloidal velocity profiles. Radial resolution after inversion is 0.6-1.8 cm from the plasma edge to the center.

  16. Shock Compression Experiments with in situ Ellipsometry Measurements

    Science.gov (United States)

    Bakshi, Lior; Eliezer, Shalom; Nissim, Noaz; Perelmutter, Lior; Sudai, Moris; Mond, Michael

    2009-06-01

    Knowledge about the optical properties of materials at high pressure and high temperature is needed for EOS research. Ellipsometry measures the change in the polarization of a probe beam reflected from a surface. From the change in polarization, the real and imaginary parts of the time dependent complex index of refraction can be extracted. From the measured optical properties, fundamental physical properties of the material, such as emissivity, phase transitions, and electrical conductivity can be extracted. A dynamic ellipsometry measurement system with nanosecond resolution was built in order to measure all four stocks parameters. Gas gun was used to accelerate the impact flyer. Our experiments concentrated on the optical properties of 1020 steel targets with impact pressure range of 40-250 kbar. Free surface measurements as well as window-target interface measurements were preformed. Although there are intrinsic difficulties with dynamic ellipsometric measurements, distinct changes were observed for shock wave pressures larger than 130kbar, the α->ɛ phase transition.

  17. A weak link in metabolism: the metabolic capacity for glycine ...

    Indian Academy of Sciences (India)

    Prakash

    2009-12-03

    Dec 3, 2009 ... synthesis in strict vegetarian humans (Rebouche and Engel. 1984; Rebouche et al. 1993) is about 0.084 mmol/day, which is insignificant for glycine production. 3.3 Summary of the capability for glycine synthesis. The results of the calculations explained above on the capability for glycine synthesis are ...

  18. A weak link in metabolism: the metabolic capacity for glycine ...

    Indian Academy of Sciences (India)

    In a previous paper, we pointed out that the capability to synthesize glycine from serine is constrained by the stoichiometry of the glycine hydroxymethyltransferase reaction, which limits the amount of glycine produced to be no more than equimolar with the amount of C1 units produced. This constraint predicts a shortage of ...

  19. Glycine/Glycolic acid based copolymers

    NARCIS (Netherlands)

    in 't Veld, P.J.A.; in 't Veld, Peter J.A.; Shen, Zheng-Rong; Shen, Z.; Takens, Gijsbert A.J.; Takens, G.A.J.; Dijkstra, Pieter J.; Feijen, Jan

    1994-01-01

    Glycine/glycolic acid based biodegradable copolymers have been prepared by ring-opening homopolymerization of morpholine-2,5-dione, and ring-opening copolymerization of morpholine-2,5-dione and glycolide. The homopolymerization of morpholine-2,5-dione was carried out in the melt at 200°C for 3 min

  20. Engineering and characterization of fluorogenic glycine riboswitches.

    Science.gov (United States)

    Ketterer, Simon; Gladis, Lukas; Kozica, Adnan; Meier, Matthias

    2016-07-08

    A set of 12 fluorogenic glycine riboswitches with different thermodynamic and kinetic response properties was engineered. For the design of functional riboswitches, a three-part RNA approach was applied based on the idea of linking a RNA sensor, transmitter and actuator part together. For the RNA sensor and actuator part, we used the tandem glycine aptamer structure from Bacillus subtillis, and fluorogenic aptamer Spinach, respectively. To achieve optimal signal transduction from the sensor to the actuator, a riboswitch library with variable transmitter was screened with a microfluidic large-scale integration chip. This allowed us to establish the complete thermodynamic binding profiles of the riboswitch library. Glycine dissociation constants of the 12 strong fluorescence response riboswitches varied between 99.7 and 570 μM. Furthermore, the kinetic glycine binding (k(on)), and dissociation (k(off)) rates, and corresponding energy barriers of the 10 strongest fluorescence response riboswitches were determined with the same chip platform. k(on) and k(off) were in the order of 10(-3)s(-1) and 10(-2)s(-1), respectively. Conclusively, we demonstrate that systematic screening of synthetic and natural linked RNA parts with microfluidic chip technology is an effective approach to rapidly generate fluorogenic metabolite riboswitches with a broad range of biophysical response properties. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  1. Glycine functionalized alumina nanoparticles stabilize collagen in ...

    Indian Academy of Sciences (India)

    ... Rao P Thanikaivelan. Volume 39 Issue 1 February 2016 pp 223-228 ... The functionalization of Al 2 O 3 nanoparticles with glycine was confirmed by Fourier transformed infrared (FT-IR) spectroscopy, X-ray diffraction, high-resolution scanning electron microscopy (HRSEM) and energy-dispersive X-ray (EDX) analysis.

  2. Identification of Rotylenchulus reniformis resistant Glycine lines

    Science.gov (United States)

    Identification of resistance to reniform nematode (Rotylenchulus reniformis) is the first step in developing resistant soybean (Glycine max) cultivars that will benefit growers in the Mid South. This study was conducted to identify soybean (G. max and G. soja) lines with resistance to this pathogen....

  3. Making Sense by Measuring Arcs: A Teaching Experiment in Angle Measure

    Science.gov (United States)

    Moore, Kevin C.

    2013-01-01

    I discuss a teaching experiment that sought to characterize precalculus students' angle measure understandings. The study's findings indicate that the students initially conceived angle measures in terms of geometric objects. As the study progressed, the students formed more robust understandings of degree and radian measures by constructing an…

  4. Vascular endothelial function is improved by oral glycine treatment in aged rats.

    Science.gov (United States)

    Gómez-Zamudio, Jaime H; García-Macedo, Rebeca; Lázaro-Suárez, Martha; Ibarra-Barajas, Maximiliano; Kumate, Jesús; Cruz, Miguel

    2015-06-01

    Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied. The aim of this work was to explore the effect of glycine on endothelial dysfunction in aged rats. Aortic rings with intact or denuded endothelium were obtained from untreated or glycine-treated male Sprague-Dawley rats at 5 and 15 months of age. Concentration-response curves to phenylephrine (PHE) were obtained from aortic rings incubated with N(G)-nitro-l-arginine methyl ester (l-NAME), superoxide dismutase (SOD), indomethacin, SC-560, and NS-398. Aortic mRNA expression of endothelial nitric oxide synthase (eNOS), NADPH oxidase 4 (NOX-4), cyclooxygenase 1 (COX-1), cyclooxygenase 2 (COX-2), tumour necrosis factor (TNF)-α, and interleukin-1 β was measured by real time RT-PCR. The endothelial modulation of the contraction by PHE was decreased in aortic rings from aged rats. Glycine treatment improved this modulator effect and increased relaxation to acetylcholine. Glycine augmented the sensitivity for PHE in the presence of l-NAME and SOD. It also reduced the contraction by incubation with indomethacin, SC-560, and NS-398. Glycine increased the mRNA expression of eNOS and decreased the expression of COX-2 and TNF-α. Glycine improved the endothelium function in aged rats possibly by enhancing eNOS expression and reducing the role of superoxide anion and contractile prostanoids that increase the nitric oxide bioavailability.

  5. Optimal Design of Experiments by Combining Coarse and Fine Measurements

    Science.gov (United States)

    Lee, Alpha A.; Brenner, Michael P.; Colwell, Lucy J.

    2017-11-01

    In many contexts, it is extremely costly to perform enough high-quality experimental measurements to accurately parametrize a predictive quantitative model. However, it is often much easier to carry out large numbers of experiments that indicate whether each sample is above or below a given threshold. Can many such categorical or "coarse" measurements be combined with a much smaller number of high-resolution or "fine" measurements to yield accurate models? Here, we demonstrate an intuitive strategy, inspired by statistical physics, wherein the coarse measurements are used to identify the salient features of the data, while the fine measurements determine the relative importance of these features. A linear model is inferred from the fine measurements, augmented by a quadratic term that captures the correlation structure of the coarse data. We illustrate our strategy by considering the problems of predicting the antimalarial potency and aqueous solubility of small organic molecules from their 2D molecular structure.

  6. The development of an instrument to measure women's experience ...

    African Journals Online (AJOL)

    ... the study was to pilot an instrument to measure women's experience in an aerobic dance class with regard to their descriptions of the general atmosphere, the music, the dance moves and routines, and the instructor. In addition, the participants were asked to rate a list of exercise benefits in order of personal importance.

  7. Dietary encapsulated glycine influences Clostridium perfringens and Lactobacilli growth in the gastrointestinal tract of broiler chickens.

    Science.gov (United States)

    Dahiya, J P; Hoehler, Dirk; Van Kessel, Andrew G; Drew, Murray D

    2007-06-01

    Three experiments were conducted to determine whether there is a causative relation between dietary glycine concentration and intestinal Clostridium perfringens growth in broiler chickens. Expt. 1 showed that glycine concentrations were higher (P perfringens type A on d 1 and d 14-21 and killed on d 28. In Expt. 2, C. perfringens populations were higher (P perfringens numbers were higher (P perfringens colonization and high intestinal lesion scores were associated with reduced performance (P perfringens growth in the intestinal tract of broiler chickens.

  8. Kinetics of the Reaction of CO2 with Aqueous Potassium Salt of Taurine and Glycine

    NARCIS (Netherlands)

    Kumar, P.S.; Hogendoorn, J.A.; Versteeg, G.F.; Feron, P.H.M.

    2003-01-01

    The kinetics of the reaction between CO2 and aqueous potassium salts of taurine and glycine was measured at 295 K in a stirred-cell reactor with a flat gas–liquid interface. For aqueous potassium taurate solutions, the temperature effect on the reaction kinetics was measured at 285 and 305 K. Unlike

  9. The Effect of Ethylene Glycol, Glycine Betaine, and Urea on Lysozyme Thermal Stability

    Science.gov (United States)

    Schwinefus, Jeffrey J.; Leslie, Elizabeth J.; Nordstrom, Anna R.

    2010-01-01

    The four-week student project described in this article is an extension of protein thermal denaturation experiments to include effects of added cosolutes ethylene glycol, glycine betaine, and urea on the unfolding of lysozyme. The transition temperatures and van't Hoff enthalpies for unfolding are evaluated for six concentrations of each cosolute,…

  10. A correlation between host-mediated expression of parasite genes as tandem inverted repeats and abrogation of development of female Heterodera glycines cyst formation during infection of Glycine max.

    Science.gov (United States)

    Klink, Vincent P; Kim, Kyung-Hwan; Martins, Veronica; Macdonald, Margaret H; Beard, Hunter S; Alkharouf, Nadim W; Lee, Seong-Kon; Park, Soo-Chul; Matthews, Benjamin F

    2009-06-01

    Host-mediated (hm) expression of parasite genes as tandem inverted repeats was investigated as a means to abrogate the formation of mature Heterodera glycines (soybean cyst nematode) female cysts during its infection of Glycine max (soybean). A Gateway-compatible hm plant transformation system was developed specifically for these experiments in G. max. Three steps then were taken to identify H. glycines candidate genes. First, a pool of 150 highly conserved H. glycines homologs of genes having lethal mutant phenotypes or phenocopies from the free living nematode Caenorhabditis elegans were identified. Second, annotation of those 150 genes on the Affymetrix soybean GeneChip allowed for the identification of a subset of 131 genes whose expression could be monitored during the parasitic phase of the H. glycines life cycle. Third, a microarray analyses identified a core set of 32 genes with induced expression (>2.0-fold, log base 2) during the parasitic stages of infection. H. glycines homologs of small ribosomal protein 3a and 4 (Hg-rps-3a [accession number CB379877] and Hg-rps-4 [accession number CB278739]), synaptobrevin (Hg-snb-1 [accession number BF014436]) and a spliceosomal SR protein (Hg-spk-1 [accession number BI451523.1]) were tested for functionality in hm expression studies. Effects on H. glycines development were observed 8 days after infection. Experiments demonstrated that 81-93% fewer females developed on transgenic roots containing the genes engineered as tandem inverted repeats. The effect resembles RNA interference. The methodology has been used here as an alternative approach to engineer resistance to H. glycines.

  11. Gas-phase lithium cation affinity of glycine.

    Science.gov (United States)

    Bourcier, Sophie; Chiaa, Ru Xuan; Mimbong, Rosa Ngo Biboum; Bouchoux, Guy

    2015-01-01

    The gas-phase lithium cation binding thermochemistry of glycine has been determined theoretically by quantum chemical calculations at the G4 level and experimentally by the extended kinetic method using electrospray ionization quadrupole time-of-flight tandem mass spectrometry. The lithium cation affinity of glycine, ∆(Li)H°(298)(GLY), i.e. the∆(Li)H°(298) of the reaction GlyLi(+)→ Gly + Li(+)) given by the G4 method is equal to 241.4 kJ.mol(-1) if only the most stable conformer of glycine is considered or to 242.3 kJ.mol(-1) if the 298K equilibrium mixture of neutral conformers is included in the calculation. The ∆(Li)H°(298)(GLY) deduced from the extended kinetic method is obviously dependent on the choice of the Li(+) affinity scale, thus∆(Li)H°(298)(GLY) is equal to 228.7±0.9(2.0) kJ.mol(- 1) if anchored to the recently re-evaluated lithium cation affinity scale but shifted to 235.4±1.0 kJ.mol(-1) if G4 computed lithium cation affinities of the reference molecules is used. This difference of 6.3 kJ.mol(-1) may originate from a compression of the experimental lithium affinity scale in the high ∆(Li)H°(298) region. The entropy change associated with the reaction GlyLi(+)→Gly + Li(+) reveals a gain of approximately 15 J.mol(-) 1.K(-1) with respect to monodentate Li(+) acceptors. The origin of this excess entropy is attributed to the bidentate interaction between the Li(+) cation and both the carbonyl oxygen and the nitrogen atoms of glycine. The computed G4 Gibbs free energy,∆(Li)G°(298)(GLY) is equal to 205.3 kJ.mol(-1), a similar result, 201.0±3.4 kJ.mol(-1), is obtained from the experiment if the∆(Li)G°(298) of the reference molecules is anchored on the G4 results.

  12. Neutral pion form factor measurement by the NA62 experiment

    Science.gov (United States)

    Zamkovsky, Michal; Ambrosino, F.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Baldini, W.; Balev, S.; Batley, J. R.; Behler, M.; Bifani, S.; Biino, C.; Bizzeti, A.; Blazek, T.; Bloch-Devaux, B.; Bocquet, G.; Bolotov, V.; Bucci, F.; Cabibbo, N.; Calvetti, M.; Cartiglia, N.; Ceccucci, A.; Cenci, P.; Cerri, C.; Cheshkov, C.; Chze, J. B.; Clemencic, M.; Collazuol, G.; Costantini, F.; Cotta Ramusino, A.; Coward, D.; Cundy, D.; Dabrowski, A.; DAgostini, G.; Dalpiaz, P.; Damiani, C.; Danielsson, H.; De Beer, M.; Dellacasa, G.; Derr, J.; Dibon, H.; Di Filippo, D.; DiLella, L.; Doble, N.; Duk, V.; Engelfried, J.; Eppard, K.; Falaleev, V.; Fantechi, R.; Fidecaro, M.; Fiorini, L.; Fiorini, M.; Fonseca Martin, T.; Frabetti, P. L.; Fucci, A.; Gallorini, S.; Gatignon, L.; Gersabeck, E.; Gianoli, A.; Giudici, S.; Gonidec, A.; Goudzovski, E.; Goy Lopez, S.; Gushchin, E.; Hallgren, B.; Hita-Hochgesand, M.; Holder, M.; Hristov, P.; Iacopini, E.; Imbergamo, E.; Jeitler, M.; Kalmus, G.; Kekelidze, V.; Kleinknecht, K.; Koval, M.; Kozhuharov, V.; Kubischta, W.; Kurshetsov, V.; Lamanna, G.; Lazzeroni, C.; Lenti, M.; Leonardi, E.; Litov, L.; Lurkin, N.; Madigozhin, D.; Maier, A.; Mannelli, I.; Marchetto, F.; Marel, G.; Markytan, M.; Marouelli, P.; Martini, M.; Masetti, L.; Massarotti, P.; Mazzucato, E.; Michetti, A.; Mikulec, I.; Misheva, M.; Molokanova, N.; Monnier, E.; Moosbrugger, U.; Morales Morales, C.; Moulson, M.; Movchan, S.; Munday, D. J.; Napolitano, M.; Nappi, A.; Neuhofer, G.; Norton, A.; Numao, T.; Obraztsov, V.; Palladino, V.; Patel, M.; Pepe, M.; Peters, A.; Petrucci, F.; Petrucci, M. C.; Peyaud, B.; Piandani, R.; Piccini, M.; Pierazzini, G.; Polenkevich, I.; Popov, I.; Potrebenikov, Y.; Raggi, M.; Renk, B.; Retire, F.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Salamon, A.; Saracino, G.; Savri, M.; Scarpa, M.; Semenov, V.; Sergi, A.; Serra, M.; Shieh, M.; Shkarovskiy, S.; Slater, M. W.; Sozzi, M.; Spadaro, T.; Stoynev, S.; Swallow, E.; Szleper, M.; Valdata-Nappi, M.; Valente, P.; Vallage, B.; Velasco, M.; Veltri, M.; Venditti, S.; Wache, M.; Wahl, H.; Walker, A.; Wanke, R.; Widhalm, L.; Winhart, A.; Winston, R.; Wood, M. D.; Wotton, S. A.; Yushchenko, O.; Zinchenko, A.; Ziolkowski, M.

    2017-07-01

    The NA62 experiment at CERN collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. The kaon beam represents a source of tagged neutral pion decays in vacuum. A measurement of the electromagnetic transition form factor slope of the neutral pion in the time-like region from ∼1 million fully reconstructed π 0 Dalitz decay is presented. The limits on dark photon production in π 0 decays from the earlier kaon experiment at CERN, NA48/2, are also reported.

  13. Measurements of the CKM angle $\\gamma$ at the LHCb experiment

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00388653; Malde, Sneha

    Two measurements of the Cabibbo-Kobayashi-Maskawa angle $\\gamma$ using $B \\to D K$ and $B^{0} \\to D K^{\\ast 0}$ decays are presented in this thesis. The subsequent $D$ meson decays to the $K_{S}^{0} \\pi^{+} \\pi^{-}$ and $K_{S}^{0} K^{+} K^{-}$ final states are studied using a binned Dalitz plot analysis. The $D$ strong-phase variation over the Dalitz plot is taken from measurements performed at the CLEO-c experiment, making the analysis independent of a model to describe the $D$ decay amplitude. Both measurements are performed using proton-proton collision data collected by the Large Hadron Collider beauty (LHCb) experiment in 2011 and 2012, corresponding to an integrated luminosity of 3 fb$^{-1}$ at centre-of-mass energies $\\sqrt{s}=$ 7 TeV and 8 TeV. The value $\\gamma=(62\\,^{+15}_{-14})^{\\circ}$ is measured using $B \\to D K$ decays and $\\gamma=(71\\pm20)^{\\circ}$ is measured using $B^{0} \\to D K^{\\ast 0}$ decays, with a second solution for each value corresponding to $\\gamma+180^{\\circ}$. The measurement...

  14. Small practices' experience with EHR, quality measurement, and incentives.

    Science.gov (United States)

    Begum, Rohima; Smith Ryan, Mandy; Winther, Chloe H; Wang, Jason J; Bardach, Naomi S; Parsons, Amanda H; Shih, Sarah C; Dudley, R Adams

    2013-11-01

    To assess clinician attitudes and experiences in Health eHearts, a quality recognition and financial incentive program using health information technology. Survey of physicians. A survey was administered to 140 lead clinicians at each participating practice. Survey domains included clinicians' experiences and attitudes toward the selected clinical quality measures focused on cardiovascular care, use of electronic health records (EHRs), technical assistance visits, quality measurement reports, and incentive payments. Responses were compared across groups of practices receiving financial incentives with those in the control (no financial rewards). Survey response rate was 74%. The majority of respondents reported receiving and reviewing the quality reports (89%), agreed with the prioritization of measures (89%), and understood the information given in the quality reports (95%). Over half of the respondents had a quality improvement visit (56%), with incentive clinicians more likely to have had a visit compared with the control group (68% vs 43%, P = .01). The incentive group respondents (92%) were more likely to report using clinical decision support system alerts than control group respondents (82%, P = .11). Clinicians in both incentive and control groups reported positive experiences with the program. No differences were detected between groups regarding agreement with selected clinical measures or their relevance to the patient population. However, clinicians in the incentive group were more likely to review quarterly performance reports and access quality improvement visits. Incentives may be used to further engage clinicians operating in small independently owned practices to participate in quality improvement activities.

  15. Nanocrystal Dissolution Kinetics and Solubility Increase Prediction from Molecular Dynamics: The Case of α-, β-, and γ-Glycine.

    Science.gov (United States)

    Parks, Conor; Koswara, Andy; Tung, Hsien-Hsin; Nere, Nandkishor K; Bordawekar, Shailendra; Nagy, Zoltan K; Ramkrishna, Doraiswami

    2017-04-03

    Nanocrystals are receiving increased attention for pharmaceutical applications due to their enhanced solubility relative to their micron-sized counterpart and, in turn, potentially increased bioavailability. In this work, a computational method is proposed to predict the following: (1) polymorph specific dissolution kinetics and (2) the multiplicative increase in the polymorph specific nanocrystal solubility relative to the bulk solubility. The method uses a combination of molecular dynamics and a parametric particle size dependent mass transfer model. The method is demonstrated using a case study of α-, β-, and γ-glycine. It is shown that only the α-glycine form is predicted to have an increasing dissolution rate with decreasing particle size over the range of particle sizes simulated. On the contrary, γ-glycine shows a monotonically increasing dissolution rate with increasing particle size and dissolves at a rate 1.5 to 2 times larger than α- or β-glycine. The accelerated dissolution rate of γ-glycine relative to the other two polymorphs correlates directly with the interfacial energy ranking of γ > β > α obtained from the dissolution simulations, where γ- is predicted to have an interfacial energy roughly four times larger than either α- or β-glycine. From the interfacial energies, α- and β-glycine nanoparticles were predicted to experience modest solubility increases of up to 1.4 and 1.8 times the bulk solubility, where as γ-glycine showed upward of an 8 times amplification in the solubility. These MD simulations represent a first attempt at a computational (pre)screening method for the rational design of experiments for future engineering of nanocrystal API formulations.

  16. Removal of brownish-black tarnish on silver–copper alloy objects with sodium glycinate

    Energy Technology Data Exchange (ETDEWEB)

    Cura D’Ars de Figueiredo, João, E-mail: joaoc@ufmg.br; Asevedo, Samara Santos, E-mail: samaranix@hotmail.com; Barbosa, João Henrique Ribeiro, E-mail: joaohrb@yahoo.com.br

    2014-10-30

    -black tarnish. Absorption spectroscopy measured the percentage of silver and copper lixiviated in immersion baths, and very small quantities of these metals were detected. Infrared absorption spectroscopy and X-ray fluorescence characterized the obtained products. The greater efficiency of the sodium glycinate solution compared to the sodium acetylglycinate solution was explained by chelation and Hard–Soft Acid–Base Theory with the aid of quantum chemical calculations.

  17. Growth of glycine ethyl ester hydrochloride and its characterizations

    Energy Technology Data Exchange (ETDEWEB)

    Venkatesan, G.; Pari, S., E-mail: sparimyur@gmail.com

    2016-11-15

    Single crystal of glycine ethyl ester hydrochloride by slow evaporation method is reported. The grown crystal characterized by single crystal X-ray diffraction, FT-IR, UV–Vis–NIR and fluorescence spectroscopy. It is established that the crystal falls under the monoclinic system and space group P21/c with the cell parameters as: a=8.565 Å, b=12.943 Å, c=6.272 Å, α=γ=90°, β=103.630º. UV–Vis–NIR spectrum shows indirect allowed transition with a band gap of 5.21 eV and other optical properties are measured. The crystal is also shown to have a high transmittance in the visible region. The third order nonlinear property and optical limiting have been investigated using Z-Scan technique. Complex impedance spectrum measured at the dc conductivity. Dependence of dielectric constant, dielectric loss and ac conductivity on frequency at different temperature of applied ac field is analyzed. The mechanical behavior has been assessed by Vickers microhardness indenter. The thermal behavior of glycine ethyl ester hydrochloride was analyzed using TG/DTA thermal curves. From the thermal study, the material was found to possess thermal stability up to 174 °C. The predicted NLO properties, UV–Vis transmittance and Z-scan studies indicate that is an attractive material for photonics optical limiting applications.

  18. Bite frequency measured by head pitch movements in grazing experiment

    DEFF Research Database (Denmark)

    Oudshoorn, Frank W.; S. Nadimi, Esmaeil; Jørgensen, Rasmus Nyholm

    2010-01-01

    Objective of the experiment was to investigate if bite frequency could be measured by registering head movements in the field. Background for this research question was the found variation of bite frequency measured on different initial grass length (Oudshoorn & Nadimi, 2008) as also documented...... bite frequency variation related to grass length and grass quality (Pulido & Leaver 2001; Barrett et al. 2003). .   Head movements and bite frequency were registered in spring and autumn in 2009, with 2x10 cows grazing two weeks in two stocking densities.  Head movements were measured by activity...... sensors placed on the head of the cows, bite frequency was registered manually by noting the rip off sound during a specified time bout. Sward registrations comprised grass length measurement by rising plate meter , grass quality by laboratory analysis of hand harvested grass simulating the cows grazing...

  19. Preliminary Results from the Smoke Aerosol Measurement Experiment - Reflight

    Science.gov (United States)

    Urban, D. L.; Ruff, G. A.; Mulholland, G. W.; Yuan, Z.; Cleary, T.; Yang, J.; Meyer, M. E.; Bryg, V. M.

    2012-01-01

    Preliminary results are presented from the Reflight of the Smoke Aerosol Measurement Experiment (SAME- R) which was conducted during Expedition 24 (July- September 2010). The reflight experiment built upon the results of the original flight during Expedition 15 by adding diagnostic measurements and expanding the test matrix. Five different materials representative of those found in spacecraft (Teflon, Kapton, cotton, silicone rubber and Pyrell) were heated to temperatures below the ignition point with conditions controlled to provide repeatable sample surface temperatures and air flow. Particle size determinations were made using aerosol instruments and by capturing particles for ground based examination in a Transmission Electron Microscope (TEM). Overall the majority of the average smoke particle sizes were found to be in the 200 to 400 nanometer range with the some of the quiescent cases producing substantially larger particles. When combined with particle morphology data from the TEM analysis, these results can be used to guide the design of future smoke detectors.

  20. The Structure of Glycine Dihydrate: Implications for the Crystallization of Glycine from Solution and Its Structure in Outer Space

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Wenqian [X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Zhu, Qiang [Department of Physics and Astronomy, High Pressure Science and Engineering Center, University of Nevada Las Vegas, Las Vegas NV 89154 USA; Department of Geosciences, Stony Brook University, Stony Brook NY 11794 USA; Hu, Chunhua Tony [Department of Chemistry, New York University, 100 Washington Square East New York NY 10003 USA

    2017-01-18

    Glycine, the simplest amino acid, is also the most polymorphous. Herein, we report the structure determination of an unknown phase of glycine which was firstly reported by Pyne and Suryanarayanan in 2001. To date, the new phase has only been prepared at 208 K as nanocrystals within ice. Through computational crystal structure prediction and powder X-ray diffraction methods, we identified this elusive phase as glycine dihydrate (GDH), representing a first report on a hydrated glycine structure. The structure of GDH has important implications for the state of glycine in aqueous solution, and the mechanisms of glycine crystallization. GDH may also be the form of glycine that comes to Earth from extraterrestrial sources.

  1. Selected Measurements of Rare Decays at the LHCb Experiment

    CERN Document Server

    Pikies, Malgorzata

    2016-01-01

    Experimental results of rare decays B$^0$$\\to K*^0\\mu\\mu$, B$^0 \\to K*^0$ee, $\\Lambda_b\\to\\Lambda\\mu\\mu$ and B$^0_s$ governed by Flavour Changing Neutral Current transitions are discussed in this paper. The angular distributions and differential branching fractions measurements were performed using data corresponding to an integrated luminosity of 3:0 fb$^{-1}$ collected at the LHCb experiment.

  2. An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor.

    Science.gov (United States)

    Wood, M W; VanDongen, H M; VanDongen, A M

    1997-02-07

    While attempting to map a central region in the M3-M4 linker of the N-methyl-D-aspartate receptor NR1 subunit, we found that mutation of a single position, Ala-714, greatly reduced the apparent affinity for glycine. Proximal N-glycosylation localized this region to the extracellular space. Glycine affinities of additional Ala-714 mutations correlated with side chain volume. Substitution of alanine 714 with cysteine did not alter glycine sensitivity, although this mutant was rapidly inhibited by dithionitrobenzoate. Glycine protected the A714C mutant from modification by dithionitrobenzoate, whereas the co-agonist L-glutamate was ineffective. These experiments place Ala-714 in the glycine binding pocket of the N-methyl-D-aspartate receptor, a determination not predicted by previous structural models based on bacterial periplasmic binding protein homology.

  3. Inhibition effect of glycine on molybdenum corrosion during CMP in alkaline H2O2 based abrasive free slurry

    Science.gov (United States)

    Yang, Guang; He, Peng; Qu, Xin-Ping

    2018-01-01

    The inhibitory effect of glycine on corrosion and chemical mechanical polishing (CMP) of Mo in hydrogen peroxide (H2O2) based abrasive-free alkaline slurry has been investigated. Results show that, in H2O2 based slurry, both static etching rate (SER) and removal rate (RR) of Mo during chemical mechanical polishing were reduced by adding glycine and the inhibition efficiency was around 50%. From ex-situ and in-situ open circuit potential (OCP), current density transient and potentiodynamic polarization measurements, it is found that formation of oxides was delayed due to blocked contact between oxidizer and the sample surface by electrostatic adsorption of glycine zwitterion on the surface. Glycine can form complex with MoO3 and promote dissolution of surface oxide, MoO3, resulting in a reduced passivation layer. The slowed oxidation reaction dominates the whole process, resulting inhibited Mo corrosion and leading to a smoother Mo surface.

  4. The Effect of External Usage of Glycine Betaine on Corn (zea mays l. in Drought Condition

    Directory of Open Access Journals (Sweden)

    H. R Miri

    2015-04-01

    Full Text Available Drought is one of the most important factors limiting crop growth and therefore use of practice to reduce its adverse effect is very important. In order to study the effect of glycine betaine on corn under drought condition an experiment was conducted as split-split plot in the base of randomized complete blocks design. The first factor was irrigation interval cycle (4 and 8 days and second factor including different concentrations of glycine betaine (zero, 50 ppm, 100 ppm,150 ppm and third was spraying in two stages (stem elongation stage and before flowering. Analysis of variance showed that effects of three factors on all of traits except for carotenoids were significant. However, foliar application of glycine betaine reduced effect of drought stress conditions on the plant so that extent of chlorophyll (a and b, plant height, yield and 1000 grain weight increased significantly. Spraying by glycine betaine caused improving plant performance in stress conditions, so that in the concentration of 150 ppm produced the highest quality in all of traits that preference was more evident before flowering. By considering these results it could be said that spraying with 150 ppm of glycine betaine before flowering in the condition of stress and without drought stress could improve the extent of chlorophyll (a and b, plant height, yield and yield components. Eventually it could be concluded that external glycine betaine with 150 ppm concentration while spraying before flowering had great positive effects and usage of that material is affected by time of application concentration and more stress severity.

  5. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.

    Science.gov (United States)

    Zhang, Long-Hua; Gong, Neng; Fei, Da; Xu, Lin; Xu, Tian-Le

    2008-02-01

    Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their role in hippocampal function remains unclear. Since the concentration of ambient glycine is determined by the presence of powerful glycine transporter (GlyT), we blocked the reuptake of glycine in hippocampal slices to examine the role of GlyRs. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. Moreover, endogenously elevating the glycine concentration with the GlyT1 antagonists facilitated NMDA receptor-dependent long-term potentiation induction, and elicited a strychnine-sensitive chloride current. In addition, impairment of glial function with fluoroacetate blocked the effect of GlyT1 antagonists on the EPSP-spike curve. Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures. These results indicate an essential role of GlyTs in fine-tuning tonic activation of GlyRs and suggest a potential role of GlyR-dependent EPSP-spike depression in hippocampal network stability.

  6. Photostability of glycine to Lyman {alpha} radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira-Rodrigues, A.M. [Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, RJ (Brazil); Homem, M.G.P. [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil); Naves de Brito, A. [Universidade de Brasilia (UnB), DF (Brazil); Ponciano, C.R.; Silveira, E.F. da [Pontificia Univ. Catolica do Rio de Janeiro (PUC-Rio), RJ (Brazil)

    2012-07-01

    Full text: The amino acids already detected in Solar System bodies and researched in Interstellar Medium are of particular importance for the chemistry related to the origin of life since they are constituents of all living organisms. To interpret the viability of amino acids in pre-biotic astrochemistry is important to investigate the stability of these compounds in extraterrestrial surroundings. This study investigates, in the laboratory, the stability of glycine to the action of ultraviolet radiation, in spectral region around the wavelength of the Lyman {alpha} line (1216 ) produced by a hydrogen lamp. {sup 252}Cf-PDMS of positive and negative desorbed ions was performed for glycine, before and during the irradiation, and the dependence of the ion desorption yields on the irradiation time is determined. As a result, the relative photostability curves of the molecular and dimer ions are observed to be a single exponential decay with a time constant 376 min for positive desorbed ions and 675 min for negative ones. The photodissociation cross section found for glycine molecule at room temperature, when positive secondary ions are considered, is 17 Mb; this value drops to 9 Mb when negative secondary ions are analyzed. This new methodology offers a complementary way of understanding the photonic interaction in amino acids, allowing discussion on polymerization and/or radiation induced phase transition effects. (author)

  7. Chemical and Mechanical Control of Soybean (Glycin max L. Weeds

    Directory of Open Access Journals (Sweden)

    Ebrahim Gholamalipour Alamdari

    2016-10-01

    Full Text Available To evaluate effects of the various concentrations of two herbicides of the trifluralin and Imazethapyr and weeding on weeds control, yield and yield components of soybean (Glycin max L., an experiment was carried out based on randomized complete block design with three replications at the Agriculture Land of Ghravolhaji Village in Kallale district of Golestan province in 2014. Treatments consisted of planting soybean under weeding, without weeding and application of trifluralin and Imazethapyr as 100% trifluralin, 75% trifluralin + 25% Imazethapyr, 50% trifluralin + 50% Imazethapyr, 25% trifluralin + 75% Imazethapyr, 100% pursuit, 100% Imazethapyr + 25% trifluralin, 25% Imazethapyr + 100% trifluralin, 100% Imazethapyr + 50% trifluralin and 50% Imazethapyr + 100% trifluralin. density of each weed, their total density and inhibition percentage were measured. Results showed that the effect of chemical weed control on all traits measured, except seed number per pot, 1000 seed weight, content of chlorophyll a and total chlorophyll, were significant. The highest leaf area, plant height, number of pods per plant, aerial plant dry weight, seed number per plant and seed weight per plant were observed in the treatment of the 100% Imazethapyr (238.67 cm2, weeding (57.69 cm, both treatments of weeding (33.10 and 25% Imazethapyr +100% trifluralin (28.3, both treatment of weeding (163.92 g and 100%  Imazethapyr (163.70 g, weeding (67.10 seed per plant, both treatment of weeding and 100%  Imazethapyr + 50% trifluralin (10.27 seed per plant respectively. The highest seed yield was obtained from weeding treatment (2383 kg/h. Based on the results, the highest content of protein and chlorophyll b in soybean were obtained from weeding treatment. The highest inhibition percentage of weeds was found in the additional treatment of 50% Imazethapyr + 100% trifluralin (75.19 and 100% Imazethapyr + 25% trifluralin (72.86. The lowest and highest total phenols content and

  8. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review

    Directory of Open Access Journals (Sweden)

    Meerza Abdul Razak

    2017-01-01

    Full Text Available Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Generally in common feeding conditions, glycine is not sufficiently synthesized in humans, animals, and birds. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. Glycine is very effective in improving the health and supports the growth and well-being of humans and animals. There are overwhelming reports supporting the role of supplementary glycine in prevention of many diseases and disorders including cancer. Dietary supplementation of proper dose of glycine is effectual in treating metabolic disorders in patients with cardiovascular diseases, several inflammatory diseases, obesity, cancers, and diabetes. Glycine also has the property to enhance the quality of sleep and neurological functions. In this review we will focus on the metabolism of glycine in humans and animals and the recent findings and advances about the beneficial effects and protection of glycine in different disease states.

  9. Investigation of the structural anisotropy in a self-assembling glycinate layer on Cu(100) by scanning tunneling microscopy and density functional theory calculations

    Energy Technology Data Exchange (ETDEWEB)

    Kuzmin, Mikhail [Surface Science Laboratory, Optoelectronics Research Centre, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere (Finland); Ioffe Physical Technical Institute, Russian Academy of Sciences, 26 Polytekhnicheskaya, St Petersburg 194021 (Russian Federation); Lahtonen, Kimmo; Vuori, Leena [Surface Science Laboratory, Optoelectronics Research Centre, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere (Finland); Sánchez-de-Armas, Rocío [Materials Theory Division, Department of Physics and Astronomy, Uppsala University, P.O. Box 516, S75120 Uppsala (Sweden); Hirsimäki, Mika, E-mail: mikahirsi@gmail.com [Surface Science Laboratory, Optoelectronics Research Centre, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere (Finland); Valden, Mika [Surface Science Laboratory, Optoelectronics Research Centre, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere (Finland)

    2017-07-01

    Highlights: • Deprotonation reaction of glycine and self-assembly of glycinate is observed on Cu. • Bias-dependent scanning tunneling microscopy indicates two glycinate geometries. • Density functional theory calculations confirm the two non-identical configurations. • Non-identical adsorption explains the anisotropy in adlayer’s electronic structure. - Abstract: Self-assembling organic molecule-metal interfaces exhibiting free-electron like (FEL) states offers an attractive bottom-up approach to fabricating materials for molecular electronics. Accomplishing this, however, requires detailed understanding of the fundamental driving mechanisms behind the self-assembly process. For instance, it is still unresolved as to why the adsorption of glycine ([NH{sub 2}(CH{sub 2})COOH]) on isotropic Cu(100) single crystal surface leads, via deprotonation and self-assembly, to a glycinate ([NH{sub 2}(CH{sub 2})COO–]) layer that exhibits anisotropic FEL behavior. Here, we report on bias-dependent scanning tunneling microscopy (STM) experiments and density functional theory (DFT) calculations for glycine adsorption on Cu(100) single crystal surface. We find that after physical vapor deposition (PVD) of glycine on Cu(100), glycinate self-assembles into an overlayer exhibiting c(2 × 4) and p(2 × 4) symmetries with non-identical adsorption sites. Our findings underscore the intricacy of electrical conductivity in nanomolecular organic overlayers and the critical role the structural anisotropy at molecule-metal interface plays in the fabrication of materials for molecular electronics.

  10. Construction and Initial Validation of the Multiracial Experiences Measure (MEM)

    Science.gov (United States)

    Yoo, Hyung Chol; Jackson, Kelly; Guevarra, Rudy P.; Miller, Matthew J.; Harrington, Blair

    2015-01-01

    This article describes the development and validation of the Multiracial Experiences Measure (MEM): a new measure that assesses uniquely racialized risks and resiliencies experienced by individuals of mixed racial heritage. Across two studies, there was evidence for the validation of the 25-item MEM with 5 subscales including Shifting Expressions, Perceived Racial Ambiguity, Creating Third Space, Multicultural Engagement, and Multiracial Discrimination. The 5-subscale structure of the MEM was supported by a combination of exploratory and confirmatory factor analyses. Evidence of criterion-related validity was partially supported with MEM subscales correlating with measures of racial diversity in one’s social network, color-blind racial attitude, psychological distress, and identity conflict. Evidence of discriminant validity was supported with MEM subscales not correlating with impression management. Implications for future research and suggestions for utilization of the MEM in clinical practice with multiracial adults are discussed. PMID:26460977

  11. Viscosity Measurement via Drop Coalescence: A Space Station Experiment

    Science.gov (United States)

    Antar, Basil; Ethridge, Edwin C.

    2010-01-01

    The concept of using low gravity experimental data together with CFD simulations for measuring the viscosity of highly viscous liquids was recently validated on onboard the International Space Station (ISS). A series of microgravity tests were conducted for this purpose on the ISS in July, 2004 and in May of 2005. In these experiments two liquid drops were brought manually together until they touched and were allowed to coalesce under the action of the capillary force alone. The coalescence process was recorded photographically from which the contact radius speed of the merging drops was measured. The liquid viscosity was determined by fitting the measured data with accurate numerical simulation of the coalescence process. Several liquids were tested and for each liquid several drop diameters were employed. Experimental and numerical results will be presented in which the viscosity of several highly viscous liquids were determined using this technique.

  12. Measurements of Beam Cooling in Muon Ionization Cooling Experiment

    Science.gov (United States)

    Mohayai, Tanaz; Snopok, Pavel; Rogers, Chris; Neuffer, David; Muon Ionization Cooling Experiment Collaboration

    2017-01-01

    Cooled muon beams are essential for production of high-flux neutrino beams at the Neutrino Factory and high luminosity muon beams at the Muon Collider. The international Muon Ionization Cooling Experiment, MICE aims to demonstrate muon beam cooling through ionization energy loss of muons in material. The standard figure of merit for cooling in MICE is the transverse RMS emittance reduction and to measure this, the individual muon positions and momenta are reconstructed using scintillating-fiber tracking detectors, before and after a low-Z absorbing material. In this study, in addition to a preview on the standard measurement technique, an alternative technique is described, which is the measurement of phase-space density using the novel Kernel Density Estimation method. Work supported by the U.S. Department of Energy under contract No. DE - AC05 - 06OR23100.

  13. Construction and initial validation of the Multiracial Experiences Measure (MEM).

    Science.gov (United States)

    Yoo, Hyung Chol; Jackson, Kelly F; Guevarra, Rudy P; Miller, Matthew J; Harrington, Blair

    2016-03-01

    This article describes the development and validation of the Multiracial Experiences Measure (MEM): a new measure that assesses uniquely racialized risks and resiliencies experienced by individuals of mixed racial heritage. Across 2 studies, there was evidence for the validation of the 25-item MEM with 5 subscales including Shifting Expressions, Perceived Racial Ambiguity, Creating Third Space, Multicultural Engagement, and Multiracial Discrimination. The 5-subscale structure of the MEM was supported by a combination of exploratory and confirmatory factor analyses. Evidence of criterion-related validity was partially supported with MEM subscales correlating with measures of racial diversity in one's social network, color-blind racial attitude, psychological distress, and identity conflict. Evidence of discriminant validity was supported with MEM subscales not correlating with impression management. Implications for future research and suggestions for utilization of the MEM in clinical practice with multiracial adults are discussed. (c) 2016 APA, all rights reserved).

  14. Electric Field Double Probe Measurements for Ionospheric Space Plasma Experiments

    Science.gov (United States)

    Pfaff, R.

    1999-01-01

    Double probes represent a well-proven technique for gathering high quality DC and AC electric field measurements in a variety of space plasma regimes including the magnetosphere, ionosphere, and mesosphere. Such experiments have been successfully flown on a variety of spacecraft including sounding rockets and satellites. Typical instrument designs involve a series of trades, depending on the science objectives, type of platform (e.g., spinning or 3-axis stabilized), expected plasma regime where the measurements will be made, available telemetry, budget, etc. In general, ionospheric DC electric field instruments that achieve accuracies of 0.1 mV/m or better, place spherical sensors at large distances (10m or more) from the spacecraft body in order to extend well beyond the spacecraft wake and sheath and to achieve large signal-to-noise ratios for DC and long wavelength measurements. Additional sets of sensors inboard of the primary, outermost sensors provide useful additional information, both for diagnostics of the plasma contact potentials, which particularly enhance the DC electric field measurements on non-spinning spacecraft, and for wavelength and phase velocity measurements that use the spaced receiver or "interferometer" technique. Accurate attitude knowledge enables B times V contributions to be subtracted from the measured potentials, and permits the measured components to be rotated into meaningful geophysical reference frames. We review the measurement technique for both DC and wave electric field measurements in the ionosphere discussing recent advances involving high resolution burst memories, multiple baseline double probes, new sensor surface materials, biasing techniques, and other considerations.

  15. Prebiotic Synthesis of Glycine from Ethanolamine in Simulated Archean Alkaline Hydrothermal Vents

    Science.gov (United States)

    Zhang, Xianlong; Tian, Ge; Gao, Jing; Han, Mei; Su, Rui; Wang, Yanxiang; Feng, Shouhua

    2017-12-01

    Submarine hydrothermal vents are generally considered as the likely habitats for the origin and evolution of early life on Earth. In recent years, a novel hydrothermal system in Archean subseafloor has been proposed. In this model, highly alkaline and high temperature hydrothermal fluids were generated in basalt-hosted hydrothermal vents, where H2 and CO2 could be abundantly provided. These extreme conditions could have played an irreplaceable role in the early evolution of life. Nevertheless, sufficient information has not yet been obtained for the abiotic synthesis of amino acids, which are indispensable components of life, at high temperature and alkaline condition. This study aims to propose a new method for the synthesis of glycine in simulated Archean submarine alkaline vent systems. We investigated the formation of glycine from ethanolamine under conditions of high temperature (80-160 °C) and highly alkaline solutions (pH = 9.70). Experiments were performed in an anaerobic environment under mild pressure (0.1-8.0 MPa) at the same time. The results suggested that the formation of glycine from ethanolamine occurred rapidly and efficiently in the presence of metal powders, and was favored by high temperatures and high pressures. The experiment provides a new pathway for prebiotic glycine formation and points out the phenomenal influence of high-temperature alkaline hydrothermal vents in origin of life in the early ocean.

  16. 2012 Next Generation Experiments to Measure the Neutron Lifetime Workshop

    CERN Document Server

    2014-01-01

    There is a great interest in improving the limits on neutron lifetime to the level of a precision of 0.1 s. The neutron lifetime is both an important fundamental quantity as well as a parameter influencing important processes such as nucleosynthesis (Helium production in the early universe) and the rate of energy production in the Sun. Aiming to create a roadmap of R&D for a next generation neutron lifetime experiment that can be endorsed by the North American neutron community, the focus of the workshop was on experiments using traps that utilize ultracold neutrons and confinement by a combination of magnetic and/or gravitational interaction in order to avoid systematic uncertainties introduced by neutron interactions with material walls. The papers in this volume summarize the limitations of present experiments, the discussion of new experiments in planning stage, and the discussion of systematic effects that must be addressed to achieve a lifetime measurement at an accuracy of 0.1 second.

  17. Removal of brownish-black tarnish on silver-copper alloy objects with sodium glycinate

    Science.gov (United States)

    de Figueiredo, João Cura D.'Ars; Asevedo, Samara Santos; Barbosa, João Henrique Ribeiro

    2014-10-01

    This article has the principal aim of presenting a new method of chemical cleaning of tarnished silver-copper alloy objects. The chemical cleaning must be harmless to the health, selective to tarnish removal, and easy to use. Sodium glycinate was selected for the study. The reactions of sodium glycinate with tarnish and the silver-copper alloy were evaluated. Products of the reaction, the lixiviated material, and the esthetics of silver-copper alloy coins (used as prototypes) were studied to evaluate if the proposed method can be applied to the cleaning of silver objects. Silver-copper alloys can be deteriorated through a uniform and superficial corrosion process that produces brownish-black tarnish. This tarnish alters the esthetic of the object. The cleaning of artistic and archeological objects requires more caution than regular cleaning, and it must take into account the procedures for the conservation and restoration of cultural heritage. There are different methods for cleaning silver-copper alloy objects, chemical cleaning is one of them. We studied two chemical cleaning methods that use sodium glycinate and sodium acetylglycinate solutions. Silver-copper alloy coins were artificially corroded in a basic thiourea solution and immersed in solutions of sodium glycinate and sodium acetylglycinate. After immersion, optical microscopy and scanning electron microscopy of the surfaces were studied. The sodium glycinate solution was shown to be very efficient in removing the brownish-black tarnish. Absorption spectroscopy measured the percentage of silver and copper lixiviated in immersion baths, and very small quantities of these metals were detected. Infrared absorption spectroscopy and X-ray fluorescence characterized the obtained products. The greater efficiency of the sodium glycinate solution compared to the sodium acetylglycinate solution was explained by chelation and Hard-Soft Acid-Base Theory with the aid of quantum chemical calculations.

  18. The Luminosity Measurement for the DZERO Experiment at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Snow, Gregory R. [Univ. of Nebraska, Lincoln, NE (United States)

    2016-08-01

    Primary project objective: The addition of University of Nebraska-Lincoln (UNL) human resources supported by this grant helped ensure that Fermilab’s DZERO experiment had a reliable luminosity measurement through the end of Run II data taking and an easily-accessible repository of luminosity information for all collaborators performing physics analyses through the publication of its final physics results. Secondary project objective: The collaboration between the UNL Instrument Shop and Fermilab’s Scintillation Detector Development Center enhanced the University of Nebraska’s future role as a particle detector R&D and production facility for future high energy physics experiments. Overall project objective: This targeted project enhanced the University of Nebraska’s presence in both frontier high energy physics research in DZERO and particle detector development, and it thereby served the goals of the DOE Office of Science and the Experimental Program to Stimulate Competitive Research (EPSCoR) for the state of Nebraska.

  19. BLT Flight Experiment Overview and In-Situ Measurements

    Science.gov (United States)

    Anderson, Brian P.; Campbell, Charles H.; Saucedo, Luis A.; Kinder, Gerald R.

    2010-01-01

    In support of the Boundary Layer Transition Flight Experiment (BLT FE) Project, a manufactured protuberance tile was installed on the port wing of Space Shuttle Orbiter Discovery for the flight of STS-119. Additional instrumentation was also installed in order to obtain more spatially resolved measurements. This paper will provide an overview of the BLT FE Project, including the project history, organizations involved, and motivations for the flight experiment. Significant efforts were made to place the protuberance at an appropriate location on the Orbiter and to design the protuberance to withstand the expected environments. Efforts were also extended to understand the as-fabricated shape of the protuberance and the thermal protection system tile configuration surrounding the protuberance. A high level overview of the in-situ flight data will be presented, along with a summary of the comparisons between pre- and post-flight analysis predictions and flight data.

  20. Time of flight measurement on the SOFIA experiment

    Energy Technology Data Exchange (ETDEWEB)

    Bail, A.; Taieb, J.; Chatillon, A.; Belier, G.; Laurent, B.; Pellereau, E. [CEA/DAM/DIF, Arpajon (France)

    2011-07-01

    The SOFIA experiment, which will be held at GSI (Darmstadt (Germany)) will allow to completely determine the mass and charge numbers of fragments produced in the fission reaction of radioactive actinides in reverse kinematics. Therefore, a dedicated setup has been developed for the Time of Flight measurement of relativistic heavy ions. The studies, which led to the choice of the adequate plastic scintillators and photomultipliers, are presented. Tests have been undertaken with the ELSA laser and electron beam facility. They shown that a suitable choice would be EJ-232 plastic scintillator for the ToF wall and EJ-232Q for the start detector and Hamamatsu H6533 and H10580 photomultipliers. This was confirmed by two test experiments realized at GSI with relativistic heavy ion beam ({sup 56}Fe and {sup 238}U), where a time of flight resolution better than 20 ps FWHM was reached. (authors)

  1. Chained Bell Inequality Experiment with High-Efficiency Measurements

    Science.gov (United States)

    Tan, T. R.; Wan, Y.; Erickson, S.; Bierhorst, P.; Kienzler, D.; Glancy, S.; Knill, E.; Leibfried, D.; Wineland, D. J.

    2017-03-01

    We report correlation measurements on two 9Be+ ions that violate a chained Bell inequality obeyed by any local-realistic theory. The correlations can be modeled as derived from a mixture of a local-realistic probabilistic distribution and a distribution that violates the inequality. A statistical framework is formulated to quantify the local-realistic fraction allowable in the observed distribution without the fair-sampling or independent-and-identical-distributions assumptions. We exclude models of our experiment whose local-realistic fraction is above 0.327 at the 95% confidence level. This bound is significantly lower than 0.586, the minimum fraction derived from a perfect Clauser-Horne-Shimony-Holt inequality experiment. Furthermore, our data provide a device-independent certification of the deterministically created Bell states.

  2. Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometry.

    Science.gov (United States)

    Rana, Namrata; McLean, Samantha; Mann, Brian E; Poole, Robert K

    2014-12-01

    Carbon monoxide (CO) is a toxic gas that binds to haems, but also plays critical signalling and cytoprotective roles in mammalian systems; despite problems associated with systemic delivery by inhalation of the gas, it may be employed therapeutically. CO delivered to cells and tissues by CO-releasing molecules (CO-RMs) has beneficial and toxic effects not mimicked by CO gas; CO-RMs are also attractive candidates as novel antimicrobial agents. Salmonella enterica serovar Typhimurium is an enteropathogen causing gastroenteritis in humans. Recent studies have implicated haem oxygenase-1 (HO-1), the protein that catalyses the degradation of haem into biliverdin, free iron and CO, in the host immune response to Salmonella infection. In several studies, CO administration via CO-RMs elicited many of the protective roles of HO-1 induction and so we investigated the effects of a well-characterized water-soluble CO-RM, Ru(CO)3Cl(glycinate) (CORM-3), on Salmonella. CORM-3 exhibits toxic effects at concentrations significantly lower than those reported to cause toxicity to RAW 264.7 macrophages. We demonstrated here, through oxyhaemoglobin assays, that CORM-3 did not release CO spontaneously in phosphate buffer, buffered minimal medium or very rich medium. CORM-3 was, however, accumulated to high levels intracellularly (as shown by inductively coupled plasma MS) and released CO inside cells. Using growing Salmonella cultures without prior concentration, we showed for the first time that sensitive dual-beam integrating cavity absorption spectrophotometry can detect directly the CO released from CORM-3 binding in real-time to haems of the bacterial electron transport chain. The toxic effects of CO-RMs suggested potential applications as adjuvants to antibiotics in antimicrobial therapy. © 2014 The Authors.

  3. The fate of 13C15N labelled glycine in permafrost and surface soil at simulated thaw in mesocosms from high arctic and subarctic ecosystems

    DEFF Research Database (Denmark)

    Ravn, Nynne Marie Rand; Elberling, Bo; Michelsen, Anders

    2017-01-01

    glycine addition. Results: Near-surface soil microbes were more efficient in the uptake of intact glycine immediately upon thaw than plants. After one month plants had gained more 15N whereas microbes seemed to lose 15N originating from glycine. We observed a time lag in glycine degradation upon...... compound in thawing permafrost and surface soil. Methods: Double labeled glycine (13C15N) was added to soil columns with vegetation and to permafrost. During thaw conditions ecosystem respiration 13C was measured and 13C and 15N distribution in the ecosystem pools was quantified one day and one month after...... permafrost thaw, in contrast to surface soil thaw. Conclusions: Our results suggest that both arctic plants and microorganisms acquire amino acids released upon spring and permafrost thaw. Despite indications of more efficient utilization of added substrate in the High Arctic than the Subarctic, we conclude...

  4. Measurement of $\\epsilon'/\\epsilon$ from the NA48 experiment

    OpenAIRE

    Ocariz, Jose

    2000-01-01

    Using data collected in 1998 by the NA48 experiment, a preliminary measurement of the direct CP violation parameter Re (ε0 /ε) is here presented, together with a discussion of the experimental method, data analysis and systematic studies. The result is Re (ε0 /ε) = (12.2 ± 4.9) × 10−4, and combined with the previously published NA48 result (based from data collected in 1997) gives Re (ε0 /ε) = (14.0 ± 4.3) × 10−4.

  5. New Experiment to Measure the Electron Electric Dipole Moment

    Science.gov (United States)

    Kittle, Melanie

    2003-01-01

    An electron can possess an electric dipole moment (edm) only if time reversal symmetry (T) is violated. No edm of any particle has yet been discovered. CP-violation, equivalent to T-violation by the CPT theorem, does occur in Kaon decays and can be accounted for by the standard model. However, this mechanism leads to an electron edm d(sub e) of the order of 10(exp -38) e cm, whereas the current experimental bound on d(sub e) is about 10(exp -27) e cm. However, well-motivated extensions of the standard model such as supersymmetric theories do predict that de could be as large as the current bound. In addition, CP violation in the early universe is required to explain the preponderance of matter over anti-matter, but the exact mechanism of this CP violation is unclear. For these reasons, we are undertaking a new experimental program to determine de to an improved accuracy of 10(exp -29) e cm. Our experiment will use laser-cooled, trapped Cesium atoms to measure the atomic edm d(sub Cs) that occurs if d(sub e) is not zero. In order to do this, we will measure the energy splitting between the atoms spin states in parallel electric and magnetic fields. The signature of an edm would be a linear dependence of the splitting on the electric field E due to the interaction - d(sub Cs) dot E. Our measurement will be much more sensitive than previous measurements because atoms can be stored in the trap for tens of seconds, allowing for much narrower Zeeman resonance linewidths. Also, our method eliminates the most important systematic errors, proportional to atomic velocity, which have limited previous experiments. In this presentation, we will describe the design of our new apparatus, which is presently under construction. An important feature of our experimental apparatus is that magnetic field noise will be suppressed to a very low value of the order of 1 fT/(Hz)1/2. This requires careful attention to the Johnson noise currents in the chamber, which have not been important

  6. Effect of methanol spraying on yield and yield components of soybean (Glycine max L.

    Directory of Open Access Journals (Sweden)

    M. Mirakhori

    2016-04-01

    Full Text Available In order to evaluate the application of methanol on yield and yield components of soybean (Glycine max L., var. L 17 in field conditions, experiments were conducted based on a randomized complete block design with three replications at the Field Research from Faculty of Agricultural of Islamic Azad University Karaj, Iran, during 2008. Sprayed aqueous solutions were zero (control, 7, 14, 21, 28 and 35% (v/v methanol by there times during growth season of soybean with 15 days intervals on shoot of soybean. In this study soybean grain yield, biomass HI, 1000 grain weigh, height plants, number of branch, diameter of stem, number of pod on plant, number of hollow pod were measured. Results of the experiment indicated that there are significant differences (p>0.05 between sprayed of solution methanol on all parameters. Results also showed the effect of aqueous solution 14, 21 and 28% (v/v methanol on measured parameters was greater than other treatments. Foliar application of 14% and 21%, (v/v methanol increased leaf area index, crop growth rate, pod growth rate, leaf area duration, pod yield, seed yield, weight of 1000 kernel, mature pods per plants. The lowest grain yield obtained in control plots and 35% (v/v methanol treatments.

  7. A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Fan Emily Y

    2011-08-01

    Full Text Available Abstract Background The β-amyloid peptide (Aβ contains a Gly-XXX-Gly-XXX-Gly motif in its C-terminal region that has been proposed to form a "glycine zipper" that drives the formation of toxic Aβ oligomers. We have tested this hypothesis by examining the toxicity of Aβ variants containing substitutions in this motif using a neuronal cell line, primary neurons, and a transgenic C. elegans model. Results We found that a Gly37Leu substitution dramatically reduced Aβ toxicity in all models tested, as measured by cell dysfunction, cell death, synaptic alteration, or tau phosphorylation. We also demonstrated in multiple models that Aβ Gly37Leu is actually anti-toxic, thereby supporting the hypothesis that interference with glycine zipper formation blocks assembly of toxic Aβ oligomers. To test this model rigorously, we engineered second site substitutions in Aβ predicted by the glycine zipper model to compensate for the Gly37Leu substitution and expressed these in C. elegans. We show that these second site substitutions restore in vivo Aβtoxicity, further supporting the glycine zipper model. Conclusions Our structure/function studies support the view that the glycine zipper motif present in the C-terminal portion of Aβ plays an important role in the formation of toxic Aβ oligomers. Compounds designed to interfere specifically with formation of the glycine zipper could have therapeutic potential.

  8. Degradation of glycine and alanine on irradiated quartz.

    Science.gov (United States)

    Pawlikowski, Maciej; Benko, Aleksandra; Wróbel, Tomasz P

    2013-04-01

    Recent researches suggest participation of minerals in the formation of life under primordial conditions. Among all of the minerals, quartz seems to be one of the most probable to take part in such processes. However, an external source of energy is needed, e.g. electric discharge. A device simulating the proposed conditions was designed and was used to simulate prebiotic conditions. Investigation of processes occurring during the stimulation of quartz with electric discharge was studied by means of Ultraviolet-visible (UV-VIS) spectroscopy, in order to monitor the generation kinetics of free radicals. Additionally, infrared spectroscopy was applied to identify chemical reaction products created in a solution of alanine or glycine, in the presence of quartz treated with electric discharge. Formation of increased amounts of free radicals, compared to experiments performed without quartz and/or amino acid, is reported, along with identification of possible degradation products of alanine. No synthetic reactions were observed.

  9. New Experiments to Measure the Muon Anomalous Gyromagnetic Moment

    CERN Document Server

    Eads, M

    2015-01-01

    The magnetic moment is a fundamental property of particles. The measurement of these magnetic moments and the comparison with the values predicted by the standard model of particle physics is a way to test our understanding of the fundamental building blocks of our world. In some cases, such as for the electron, this comparison has resulted in confirmation of the standard model with incredible precision. In contrast, the magnetic moment of the muon has shown a long-standing disagreement in the measured and the predicted value. There is currently a tantalizing three-standard-deviation difference between the current best measurement (with a precision of 0.54 ppm) and the state-of-the-art standard model prediction. This represents one of the very few experimental hints for physics beyond the standard model. There are currently two major experimental efforts underway to improve the precision of the muon magnetic moment measurement. The first is an evolution of the E-821 experiment, originally located at Brookhave...

  10. Measuring CMB polarization from ISS: the SPOrt experiment

    Energy Technology Data Exchange (ETDEWEB)

    Colombo, L.P.L. [Physics Dep. ' G. Occhialini' , Universita di Milano-Bicocca and INFN sezione di Milano-Bicocca, Piazza della Scienza, 3 I-20126 Milan (Italy)

    2004-09-01

    The SPOrt (Sky Polarization Observatory) experiment aims to measure CMBP (cosmic microwave background polarization) on about 80% of the sky from space. Selected by ESA to fly on board the ISS in 2006, it is funded by the Italian Space Agency (ASI). As shown also by the recent WMAP release, CMBP data, besides of removing various degeneracies among cosmological parameters, provided new and important information on the cosmic opacity {tau} and, therefore, on very early cosmic objects which reionized the world at z {approx} 15. Most such information is obtained from low-l spectral components, that SPOrt, with its HPBW resolution of 7 degrees will explore with a high level of sensitivity. The 4 polarimeters of SPOrt work at 22, 32 and (2x) 90 GHz. At lower frequencies they will provide a (nearly) all-sky survey of Galactic synchrotron polarized emission, while data at the higher frequency will measure the CMBP signal. Correlating SPOrt with anisotropy data, by other experiments, shall therefore provide significant cosmological information. We performed a number of simulations of SPOrt performance, aimed to determine how far {tau} and/or other parameter(s) concerning reionization are constrained by the expected data. We also considered a possible interplay between reionization histories and Dark Energy nature. Besides of information on technological developments for systematics reduction, long term stability and observing time efficiency, we report here recent outputs on the expected SPOrt performance in constraining cosmological models.

  11. Synthesis and distribution of N-benzyloxycarbonyl-[{sup 14}C]-glycine, a lipophilic derivative of glycine

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, D.M.; Gallez, Bernard; Poupaert, J.H. [Universite Catholique de Louvain, Brussels (Belgium). Dept. des Sciences Pharmaceutiques

    1995-12-31

    N-benzyloxycarbonyl[{sup 14}C]-glycine, a lipophilic derivative of glycine exhibiting anticonvulsant properties, was prepared in one step from [U-{sup 14}C] glycine and benzyl chloroformate in alkali medium. a comparative study of biodistribution was carried on mice between this compound and the parent amino-acid after intravenous administration. Dimethylsulfoxide was used as injection vehicle for N-benzyloxycarbonylglycine. The influence of this injection vehicle was studied comparing glycine injected in a saline solution and glycine co-administered with dimethylsulfoxide. No significant difference was found between these two treatments. Compared to glycine, N-benzyloxycarbonylglycine reached quickly the central nervous system and exhibited an enhanced brain penetration index, 13-fold superior to the parent aminoacid value. (Author).

  12. The Chesapeake Lighthouse and Aircraft Measurements for Satellites (CLAMS) Experiment

    Science.gov (United States)

    Smith, William L., Jr.; Charlock, Thomas; Wielicki, Bruce; Kahn, Ralph; Martins, J. Vanderlei; Gatebe, Charles; Hobbs, Peter V.; Purgold, G. Carl; Redemann, Jens; Remer, Lorraine

    2004-01-01

    NASA has developed an Earth Observing System (EOS) consisting of a series of satellites designed to study global change from space. The EOS flagship is the EOS TERRA satellite, launched in December 1999, equipped with five unique sensors to monitor and study the Earth s heat budget and many of the key controlling variables governing the Earth's climate system. CLAMS, the Chesapeake Lighthouse and Aircraft Measurements for Satellites field campaign was conducted from NASA Wallops Flight Facility and successfully executed over the middle Atlantic eastern seaboard from July 10 August 2, 2001. CLAMS is primarily a shortwave closure experiment designed to validate and improve EOS TERRA satellite data products being derived from three sensors: CERES (Clouds and Earth's Radiant Energy System), MISR (Multi-angle Imaging Spectro-Radiometer) and MODIS (MODerate Resolution Imaging Spectroradiometer). CLAMS is jointly sponsored by the CERES, MISR and MODIS instrument teams and the NASA GEWEX Global Aerosol Climatology Project (GACP). CLAMS primary objectives are to validate satellite-based retrievals of aerosol properties and vertical profiles of radiative flux, temperature and water vapor. Central to CLAMS measurement strategy is the Chesapeake Lighthouse, a stable sea platform located in the Atlantic Ocean, 13 miles east of Virginia Beach near the mouth of the Chesapeake Bay and the site of an ongoing CERES Ocean Validation Experiment (COVE). Six research aircraft were deployed to make detailed measurements of the atmosphere and ocean surface in the vicinity of COVE, over the surrounding ocean, over nearby NOAA buoys and over a few land sites. The measurements are used to validate and provide ground truth for simultaneous products being derived from TERRA data, a key step toward an improved understanding and ability to predict changes in the Earth's climate. One of the two CERES instruments on-board TERRA was programmed for Rotating Azimuth Plane Scans (RAPS) during CLAMS

  13. Measurements of turbulent dissipation during the Bahamas Optical Turbulence Experiment

    Science.gov (United States)

    Matt, Silvia; Hou, Weilin; Woods, Sarah; Jarosz, Ewa; Goode, Wesley; Weidemann, Alan

    2013-06-01

    The Bahamas Optical Turbulence Experiment (BOTEX) was conducted in the summer of 2011 to investigate the impact of turbulence on underwater optical imaging. Underwater optical properties can be affected by turbulence in the water, due to localized changes in the index of refraction. We discuss measurements of current velocity and temperature, made with a Nortek Vector Acoustic Doppler Velocimeter (ADV) and PME Conductivity- Temperature (CT) probe, as well as observations made with a Rockland Oceanographic Vertical Microstructure Profiler (VMP). The instruments were deployed in close proximity in the field and in the context of measurements of optical target clarity. Turbulent kinetic energy dissipation (TKED) and temperature dissipation (TD) rates are calculated from the ADV/CT measurements and compared to TKED and TD estimated from the data collected with the VMP. The results show reasonable agreement between the two methods; differences are attributed to turbulence patchiness and intermittence, as well as sampling challenges. The study also highlights the importance of collecting concurrent data on temperature, current velocity, and current shear to assess the turbulence impact on underwater optical properties.

  14. Simulated Measurements of Cooling in Muon Ionization Cooling Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Mohayai, Tanaz [IIT, Chicago; Rogers, Chris [Rutherford; Snopok, Pavel [Fermilab

    2016-06-01

    Cooled muon beams set the basis for the exploration of physics of flavour at a Neutrino Factory and for multi-TeV collisions at a Muon Collider. The international Muon Ionization Cooling Experiment (MICE) measures beam emittance before and after an ionization cooling cell and aims to demonstrate emittance reduction in muon beams. In the current MICE Step IV configuration, the MICE muon beam passes through low-Z absorber material for reducing its transverse emittance through ionization energy loss. Two scintillating fiber tracking detectors, housed in spectrometer solenoid modules upstream and downstream of the absorber are used for reconstructing position and momentum of individual muons for calculating transverse emittance reduction. However, due to existence of non-linear effects in beam optics, transverse emittance growth can be observed. Therefore, it is crucial to develop algorithms that are insensitive to this apparent emittance growth. We describe a different figure of merit for measuring muon cooling which is the direct measurement of the phase space density.

  15. Measurement of electron neutrino appearance with the MINOS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, Joshua Adam Alpern [Harvard Univ., Cambridge, MA (United States)

    2009-05-01

    MINOS is a long-baseline two-detector neutrino oscillation experiment that uses a high intensity muon neutrino beam to investigate the phenomena of neutrino oscillations. By measuring the neutrino interactions in a detector near the neutrino source and again 735 km away from the production site, it is possible to probe the parameters governing neutrino oscillation. The majority of the vμ oscillate to vτ but a small fraction may oscillate instead to ve. This thesis presents a measurement of the ve appearance rate in the MINOS far detector using the first two years of exposure. Methods for constraining the far detector backgrounds using the near detector measurements is discussed and a technique for estimating the uncertainty on the background and signal selection are developed. A 1.6σ excess over the expected background rate is found providing a hint of ve appearance.

  16. Online Radiation Dose Measurement System for ATLAS experiment

    CERN Document Server

    Mandić, I; The ATLAS collaboration

    2012-01-01

    Particle detectors and readout electronics in the high energy physics experiment ATLAS at the Large Hadron Collider at CERN operate in radiation field containing photons, charged particles and neutrons. The particles in the radiation field originate from proton-proton interactions as well as from interactions of these particles with material in the experimental apparatus. In the innermost parts of ATLAS detector components will be exposed to ionizing doses exceeding 100 kGy. Energetic hadrons will also cause displacement damage in silicon equivalent to fluences of several times 10e14 1 MeV-neutrons per cm2. Such radiation doses can have severe influence on the performance of detectors. It is therefore very important to continuously monitor the accumulated doses to understand the detector performance and to correctly predict the lifetime of radiation sensitive components. Measurements of doses are important also to verify the simulations and represent a crucial input into the models used for predicting future ...

  17. Measurement of Neutrino Oscillation by the K2K Experiment

    CERN Document Server

    Ahn, M H; Andringa, S; Aoki, S; Aoyama, Y; Argyriades, J; Asakura, K; Ashie, R; Berghaus, F; Berns, H G; Bhang, H; Blondel, A; Borghi, S; Bouchez, J; Boyd, S C; Burguet-Castell, J; Casper, D; Catala, J; Cavata, C; Cervera-Villanueva, Anselmo; Chen, S M; Cho, K O; Choi, J H; Dore, U; Echigo, S; Espinal, X; Fechner, M; Fernández, E; Fujii, K; Fujii, Y; Fukuda, S; Fukuda, Y; Gómez-Cadenas, Juan José; Gran, R; Hara, T; Hasegawa, M; Hasegawa, T; Hayashi, K; Hayato, Y; Helmer, R L; Higuchi, I; Hill, J; Hiraide, K; Hirose, E; Hosaka, J; Ichikawa, A K; Ieiri, M; Iinuma, M; Ikeda, A; Inagaki, T; Ishida, T; Ishihara, K; Ishii, H; Ishii, T; Ishino, H; Ishitsuka, M; Itow, Y; Iwashita, T; Jang, H I; Jang, J S; Jeon, E J; Jeong, I S; Joo, K K; Jover, G; Jung, C K; Kajita, T; Kameda, J; Kaneyuki, K; Kang, B H; Kato, I; Kato, Y; Kearns, E; Kerr, D; Kim, C O; Khabibullin, M; Khotjantsev, A; Kielczewska, D; Kim, B J; Kim, H I; Kim, J H; Kim, J Y; Kim, S B; Kitamura, M; Kitching, P; Kobayashi, K; Kobayashi, T; Kohama, M; Konaka, A; Koshio, Y; Kropp, W; Kubota, J; Kudenko, Yu G; Kume, G; Kuno, Y; Kurimoto, Y; Kutter, T; Learned, J; Likhoded, S; Lim, I T; Lim, S H; Loverre, P F; Ludovici, L; Maesaka, H; Mallet, J; Mariani, C; Martens, K; Maruyama, T; Matsuno, S; Matveev, V; Mauger, C; McConnel Mahn, K B; McGrew, C; Mikheyev, S; Minakawa, M; Minamino, A; Mine, S; Mineev, O V; Mitsuda, C; Mitsuka, G; Miura, M; Moriguchi, Y; Morita, T; Moriyama, S; Nakadaira, T; Nakahata, M; Nakamura, K; Nakano, I; Nakata, F; Nakaya, T; Nakayama, S; Namba, T; Nambu, R; Nawang, S; Nishikawa, K; Nishino, H; Nishiyama, S; Nitta, K; Noda, S; Noumi, H; Nova, F; Novella, P; Obayashi, Y; Okada, A; Okumura, K; Okumura, M; Onchi, M; Oser, S M; Otaki, T; Oyama, Y; Pac, M Y; Park, H; Pierre, F; Rodríguez, A; Saji, C; Sakai, A; Sakuda, M; Sakurai, N; Sánchez, F; Sarrat, A; Sasaki, T; Sato, H; Sato, K; Scholberg, K; Schroeter, R; Sekiguchi, M; Seo, E; Sharkey, E; Shima, A; Shiozawa, M; Shiraishi, K; Sitjes, G; Smy, M B; So, H; Sobel, H; Sorel, M; Stone, J; Sulak, L; Suga, Y; Suzuki, A; Suzuki, Y; Tada, M; Takahashi, T; Takasaki, M; Takatsuki, M; Takenaga, Y; Takenaka, K; Takeuchi, H; Takeuchi, Y; Taki, K; Takubo, Y; Tamura, N; Tanaka, H; Tanaka, K; Tanaka, M; Tanaka, Y; Tashiro, K; Terri, R; T'Jampens, S; Tornero-Lopez, A; Toshito, T; Totsuka, Y; Ueda, S; Vagins, M; Whitehead, L; Walter, C W; Wang, W; Wilkes, R J; Yamada, S; Yamada, Y; Yamamoto, S; Yamanoi, Y; Yanagisawa, C; Yershov, N V; Yokoyama, H; Yokoyama, M; Yoo, J; Yoshida, M

    2006-01-01

    We present measurements of nu_mu disappearance in K2K, the KEK to Kamioka long-baseline neutrino oscillation experiment. One hundred and twelve beam-originated neutrino events are observed in the fiducial volume of Super-Kamiokande with an expectation of 158.1^{+9.2}_{-8.6} events without oscillation. A distortion of the energy spectrum is also seen in 58 single-ring muon-like events with reconstructed energies. The probability that the observations are explained by the expectation for no neutrino oscillation is 0.0015% (4.3sigma). In a two flavor oscillation scenario, the allowed Delta m^2 region at sin^2(2theta) is between 1.9 and 3.5 x 10^{-3} eV^2 at the 90% C.L. with a best-fit value of 2.8 x 10^{-3} eV^2.

  18. Validation of ozone measurements from the Atmospheric Chemistry Experiment (ACE

    Directory of Open Access Journals (Sweden)

    E. Dupuy

    2009-01-01

    Full Text Available This paper presents extensive {bias determination} analyses of ozone observations from the Atmospheric Chemistry Experiment (ACE satellite instruments: the ACE Fourier Transform Spectrometer (ACE-FTS and the Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (ACE-MAESTRO instrument. Here we compare the latest ozone data products from ACE-FTS and ACE-MAESTRO with coincident observations from nearly 20 satellite-borne, airborne, balloon-borne and ground-based instruments, by analysing volume mixing ratio profiles and partial column densities. The ACE-FTS version 2.2 Ozone Update product reports more ozone than most correlative measurements from the upper troposphere to the lower mesosphere. At altitude levels from 16 to 44 km, the average values of the mean relative differences are nearly all within +1 to +8%. At higher altitudes (45–60 km, the ACE-FTS ozone amounts are significantly larger than those of the comparison instruments, with mean relative differences of up to +40% (about +20% on average. For the ACE-MAESTRO version 1.2 ozone data product, mean relative differences are within ±10% (average values within ±6% between 18 and 40 km for both the sunrise and sunset measurements. At higher altitudes (~35–55 km, systematic biases of opposite sign are found between the ACE-MAESTRO sunrise and sunset observations. While ozone amounts derived from the ACE-MAESTRO sunrise occultation data are often smaller than the coincident observations (with mean relative differences down to −10%, the sunset occultation profiles for ACE-MAESTRO show results that are qualitatively similar to ACE-FTS, indicating a large positive bias (mean relative differences within +10 to +30% in the 45–55 km altitude range. In contrast, there is no significant systematic difference in bias found for the ACE-FTS sunrise and sunset measurements.

  19. Measurement of double-beta-decay—experiments TGV and NEMO

    Science.gov (United States)

    Štekl, I.

    2001-06-01

    A description of the aim and present status of the experiments NEMO and TGV are presented. The NEMO collaboration developed the detector NEMO-2 to investigate double-beta ( ββ) decay of 100Mo, 116Cd, 82Se and 96Zr. The results obtained for the above mentioned isotopes are given. The new detector NEMO-3, which is approximately 20 times larger than NEMO-2, is under construction. The NEMO-3 detector should allow the study of 0 νββ decays of 100Mo (or other isotopes) with half-life ˜10 25years, corresponding to neutrino masses of 0.1- 0.3 eV. The TGV I collaboration has studied the ββ decay of 48Ca. The result T 2 νββ1/2=(4.2 +3.3-1.3)×10 19 years has been found. Experiment TGV II is devoted to measurement of the ββ decay (β +β +, β +/ EC, EC/ EC) of 106Cd, particularly the 2 νEC/EC mode.

  20. Genome Duplication in Soybean (Glycine Subgenus Soja)

    Science.gov (United States)

    Shoemaker, R. C.; Polzin, K.; Labate, J.; Specht, J.; Brummer, E. C.; Olson, T.; Young, N.; Concibido, V.; Wilcox, J.; Tamulonis, J. P.; Kochert, G.; Boerma, H. R.

    1996-01-01

    Restriction fragment length polymorphism mapping data from nine populations (Glycine max X G. soja and G. max X G. max) of the Glycine subgenus soja genome led to the identification of many duplicated segments of the genome. Linkage groups contained up to 33 markers that were duplicated on other linkage groups. The size of homoeologous regions ranged from 1.5 to 106.4 cM, with an average size of 45.3 cM. We observed segments in the soybean genome that were present in as many as six copies with an average of 2.55 duplications per segment. The presence of nested duplications suggests that at least one of the original genomes may have undergone an additional round of tetraploidization. Tetraploidization, along with large internal duplications, accounts for the highly duplicated nature of the genome of the subgenus. Quantitative trait loci for seed protein and oil showed correspondence across homoeologous regions, suggesting that the genes or gene families contributing to seed composition have retained similar functions throughout the evolution of the chromosomes. PMID:8878696

  1. A postmortem study of glycine and its potential precursors in chronic schizophrenics.

    Science.gov (United States)

    Kurumaji, A; Watanabe, A; Kumashiro, S; Semba, J; Toru, M

    1996-09-01

    We have measured the concentrations of glycine and its potential precursors, serine and threonine, in 20 areas of the postmortem brains of chronic schizophrenics and controls using high-performance liquid chromatography by pre-column derivatization with dimethyl-amino-azobenzene sulphonyl chloride. The regional distribution pattern of glycine in the postmortem brains with and without the disease was more similar to that of serine (r = 0.874, P threonine (r = 0.476, P threonine was also observed in the supramarginal cortex and posterior portion of the lateral occipitotemporal cortex of the off-drug group of schizophrenics and in the putamen of all schizophrenics. The highly similar distribution pattern of glycine and serine in the postmortem brains supports the close coupling of synthesis and metabolism between these chemicals in human brains. The increased content of glycine in the orbitofrontal cortex, the reduced level of serine in the putamen and the decrease in threonine in the cerebral cortices, which were prominent in the off-drug schizophrenics, may be involved in the pathophysiology of schizophrenia.

  2. Phytoremediation of Lead Polluted Soil by Glycine max L.

    Directory of Open Access Journals (Sweden)

    Sesan Abiodun Aransiola

    2013-01-01

    Full Text Available A study was designed to assess the phytoextraction potential of Glycine max L. for lead (Pb. Pots experiment was conducted. Viable seeds were planted in 5 kg of soil placed in each plastic pot having 0 ppm (control, 5 ppm, 10 ppm, 15 ppm, 20 ppm and 25 ppm of Pb respectively. The study was carried out for a period of 12 weeks under natural conditions. Physicochemical properties of the soil were determined using standard methods. The results revealed that pH, phosphorous and moisture contents increased while nitrogen and organic carbon contents decreased in polluted soil remediated with Glycine max L. compared to the unpolluted soil. Leaf, stem, seeds and roots of the plant were analyzed for Pb uptake after 12 weeks. The plants mopped up substantial concentration of Pb in the above plant biomass of the seeds (4.2 mg/kg, stem (1.37 mg/kg and leaves (3.37 mg/kg compared to concentrations in the roots (1.53 mg/kg. The phytoextraction ability of the plant was assessed in terms of its bioconcentration factor (BCF and translocation factor (TF. It was observed that the levels of Pb in the roots and shoots after 12 weeks showed that more bioavailable pool of Pb was translocated from the root to seeds, leaves and stem in that order. The results obtained suggest that the plant has phytoextraction ability and could be used in restoring soil polluted with Pb.

  3. Potential Immune Modularly Role of Glycine in Oral Gingival Inflammation

    Directory of Open Access Journals (Sweden)

    Teresa Schaumann

    2013-01-01

    Full Text Available Gingival epithelial cells (GECs represent a physical barrier against bacteria and are involved in the processes of innate immunity. Recently, an anti-inflammatory and immune-modulatory effect of the amino acid glycine has been demonstrated. However, there is only little information about the immune-modulatory effects of glycine in oral tissues. This study aimed to investigate the existence and role of the glycine receptor in gingival tissue analyzing tissues/cells from extracted human molars via immunohistochemical analysis. In vitro, GECs were challenged by inflammatory conditions with IL-1β alone or in combination with glycine and analyzed for cytokine expression of IL6/IL8 via real-time PCR. On protein level, the effect of nuclear translocalization of NFκB protein p65 was analyzed using immunofluorescence analysis. A distinct proof of the GlyR in oral gingival tissue and keratinocytes could be demonstrated. Isolated challenge of the keratinocytes with IL-1β as well as with glycine resulted in an upregulation of IL6 and IL8 mRNA expression and activation of NFκB pathway. The presence of glycine in combination with the inflammatory stimulus led to a significant decrease in inflammatory parameters. These results indicate a possible anti-inflammatory role of glycine in gingival inflammation and encourage further research on the utility of glycine in the prevention or therapy of inflammatory periodontitis.

  4. Do glycine-extended hormone precursors have clinical significance?

    DEFF Research Database (Denmark)

    Rehfeld, Jens Frederik

    2014-01-01

    and clinical effects of glycine-extended precursors for most other amidated hormones than gastrin and cholecystokinin (CCK). The idea of glycine-extended peptides as independent messengers was interesting. But clinical science has to move ahead from ideas that cannot be supported at key points after decades...

  5. 21 CFR 522.518 - Cupric glycinate injection.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Cupric glycinate injection. 522.518 Section 522.518 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED....518 Cupric glycinate injection. (a) Specifications. Each milliliter (mL) of sterile aqueous suspension...

  6. Quantifying the Temperature Dependence of Glycine Betaine RNA Duplex Destabilization

    Science.gov (United States)

    Schwinefus, Jeffrey J.; Menssen, Ryan J.; Kohler, James M.; Schmidt, Elliot C.; Thomas, Alexandra L.

    2013-01-01

    Glycine betaine stabilizes folded protein structure due to its unfavorable thermodynamic interactions with amide oxygen and aliphatic carbon surface area exposed during protein unfolding. However, glycine betaine can attenuate nucleic acid secondary structure stability, although its mechanism of destabilization is not currently understood. In this work we quantify glycine betaine interactions with the surface area exposed during thermal denaturation of nine RNA dodecamer duplexes with guanine-cytosine (GC) contents of 17–100%. Hyperchromicity values indicate increasing glycine betaine molality attenuates stacking. Glycine betaine destabilizes higher GC content RNA duplexes to a greater extent than low GC content duplexes due to greater accumulation at the surface area exposed during unfolding. The accumulation is very sensitive to temperature and displays characteristic entropy-enthalpy compensation. Since the entropic contribution to the m-value (used to quantify GB interaction with the RNA solvent accessible surface area exposed during denaturation) is more dependent on temperature than the enthalpic contribution, higher GC content duplexes with their larger transition temperatures are destabilized to a greater extent than low GC content duplexes. The concentration of glycine betaine at the RNA surface area exposed during unfolding relative to bulk was quantified using the solute partitioning model. Temperature correction predicts a glycine betaine concentration at 25 °C to be nearly independent of GC content, indicating that glycine betaine destabilizes all sequences equally at this temperature. PMID:24219229

  7. PAMELA: A Satellite Experiment for Antiparticles Measurement in Cosmic Rays

    Science.gov (United States)

    Bongi, M.; Adriani, O.; Ambriola, M.; Bakaldin, A.; Barbarino, G. C.; Basili, A.; Bazilevskaja, G.; Bellotti, R.; Bencardino, R.; Boezio, M.; Bogomolov, E. A.; Bonechi, L.; Bongiorno, L.; Bonvicini, V.; Boscherini, M.; Cafagna, F. S.; Campana, D.; Carlson, P.; Casolino, M.; Castellini, G.; Circella, M.; De Marzo, C. N.; De Pascale, M. P.; Furano, G.; Galper, A. M.; Giglietto, N.; Grigorjeva, A.; Koldashov, S. V.; Korotkov, M. G.; Krut'kov, S. Y.; Lund, J.; Lundquist, J.; Menicucci, A.; Menn, W.; Mikhailov, V. V.; Minori, M.; Mirizzi, N.; Mitchell, J. W.; Mocchiutti, E.; Morselli, A.; Mukhametshin, R.; Orsi, S.; Osteria, G.; Papini, P.; Pearce, M.; Picozza, P.; Ricci, M.; Ricciarini, S. B.; Romita, M.; Rossi, G.; Russo, S.; Schiavon, P.; Simon, M.; Sparvoli, R.; Spillantini, P.; Spinelli, P.; Stochaj, S. J.; Stozhkov, Y.; Straulino, S.; Streitmatter, R. E.; Taccetti, F.; Vacchi, A.; Vannuccini, E.; Vasilyev, G. I.; Voronov, S. A.; Wischnewski, R.; Yurkin, Y.; Zampa, G.; Zampa, N.

    2004-06-01

    PAMELA is a satellite-borne experiment that will study the antiproton and positron fluxes in cosmic rays in a wide range of energy (from 80 MeV up to 190 GeV for antiprotons and from 50 MeV up to 270 GeV for positrons) and with high statistics, and that will measure the antihelium/helium ratio with a sensitivity of the order of 10/sup -8/. The detector will fly on-board a polar orbiting Resurs DK1 satellite, which will be launched into space by a Soyuz rocket in 2004 from Baikonur cosmodrome in Kazakhstan, for a 3-year-long mission. Particle identification and energy measurements are performed in the PAMELA apparatus using the following subdetectors: a magnetic spectrometer made up of a permanent magnet equipped with double-sided microstrip silicon detectors, an electromagnetic imaging calorimeter composed of layers of tungsten absorber and silicon detectors planes, a transition radiation detector made of straw tubes interleaved with carbon fiber radiators, a plastic scintillator time-of-flight and trigger system, a set of anticounter plastic scintillator detectors, and a neutron detector. The features of the detectors and the main results obtained in beam test sessions are presented.

  8. A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate

    Directory of Open Access Journals (Sweden)

    Okamura Yasushi

    2010-01-01

    Full Text Available Abstract Background Rhythmic motor patterns for locomotion in vertebrates are generated in spinal cord neural networks known as spinal Central Pattern Generators (CPGs. A key element in pattern generation is the role of glycinergic synaptic transmission by interneurons that cross the cord midline and inhibit contralaterally-located excitatory neurons. The glycinergic inhibitory drive permits alternating and precisely timed motor output during locomotion such as walking or swimming. To understand better the evolution of this system we examined the physiology of the neural network controlling swimming in an invertebrate chordate relative of vertebrates, the ascidian larva Ciona intestinalis. Results A reduced preparation of the larva consisting of nerve cord and motor ganglion generates alternating swimming movements. Pharmacological and genetic manipulation of glycine receptors shows that they are implicated in the control of these locomotory movements. Morphological molecular techniques and heterologous expression experiments revealed that glycine receptors are inhibitory and are present on both motoneurones and locomotory muscle while putative glycinergic interneurons were identified in the nerve cord by labeling with an anti-glycine antibody. Conclusions In Ciona intestinalis, glycine receptors, glycinergic transmission and putative glycinergic interneurons, have a key role in coordinating swimming movements through a simple CPG that is present in the motor ganglion and nerve cord. Thus, the strong association between glycine receptors and vertebrate locomotory networks may now be extended to include the phylum chordata. The results suggest that the basic network for 'spinal-like' locomotion is likely to have existed in the common ancestor of extant chordates some 650 M years ago.

  9. The Influence of Mineral Matrices on the Thermal Behavior of Glycine

    Science.gov (United States)

    Dalai, Punam; Pleyer, Hannes Lukas; Strasdeit, Henry; Fox, Stefan

    2017-12-01

    On the Hadean-Early Archean Earth, the first islands must have provided hot and dry environments for abiotically formed organic molecules. The heat sources, mainly volcanism and meteorite impacts, were also available on Mars during the Noachian period. In recent work simulating this scenario, we have shown that neat glycine forms a black, sparingly water-soluble polymer ("thermomelanoid") when dry-heated at 200 °C under pure nitrogen. The present study explores whether relevant minerals and mineral mixtures can change this thermal behavior. Most experiments were conducted at 200 or 250 °C for 2 or 7 days. The mineral matrices used were phyllosilicates (Ca-montmorillonites SAz-1 and STx-1, Na-montmorillonite SAz-1-Na, nontronite NAu-1, kaolinite KGa-1), salts (NaCl, NaCl-KCl, CaCl2, artificial sea salt, gypsum, magnesite), picritic basalt, and three Martian regolith simulants (P-MRS, S-MRS, JSC Mars-1A). The main analytical method employed was high-performance liquid chromatography (HPLC). Glycine intercalated in SAz-1 and SAz-1-Na was well protected against thermomelanoid formation and sublimation at 200 °C: after 2 days, 95 and 79 %, respectively, had either survived unaltered or been transformed into the cyclic dipeptide (DKP) and linear peptides up to Gly6. The glycine survival rate followed the order SAz-1 > SAz-1-Na > STx-1 ≈ NAu-1 > KGa-1. Very good protection was also provided by artificial sea salt (84 % unaltered glycine after 200 °C for 7 days). P-MRS promoted the condensation up to Gly6, consistent with its high phyllosilicate content. The remaining matrices were less effective in preserving glycine as such or as peptides.

  10. Experiment to measure oxygen opacity at high density and temperature

    Science.gov (United States)

    Keiter, Paul; Mussack, Katie; Orban, Chris; Colgan, James; Ducret, Jean-Eric; Fontes, Christopher J.; Guzik, Joyce Ann; Heeter, Robert F.; Kilcrease, Dave; Le Pennec, Maelle; Mancini, Roberto; Perry, Ted; Turck-Chièze, Sylvaine; Trantham, Matt

    2017-06-01

    In recent years, there has been a debate over the abundances of heavy elements (Z >2) in the solar interior. Recent solar atmosphere models [Asplund 2009] find a significantly lower abundance for C, N, and O compared to models used roughly a decade ago. This discrepancy has led to an investigation of opacities through laboratory experiments and improved opacity models for many of the larger contributors to the sun’s opacity, including iron and oxygen. Recent opacity measurements of iron disagree with opacity model predictions [Bailey et al, 2015]. Although these results are still controversial, repeated scrutiny of the experiment and data has not produced a conclusive reason for the discrepancy. New models have been implemented in the ATOMIC opacity code for C, O and Fe to address the solar abundance issue [Colgan, 2013]. Armstrong et al [2014] have also implemented changes in the ATOMIC code for low-Z elements. However, no data currently exists to test the low-Z material models in the regime relevant to the solar convection zone. We present an experimental design using the opacity platform developed at the National Ignition Facility to study the oxygen opacity at densities and temperatures near the solar convection zone conditions.This work is funded by the U.S. DOE, through the NNSA-DS and SC-OFES Joint Program in HEDPLP, grant No. DE-NA0001840, and the NLUF Program, grant No. DE-NA0000850, and through LLE, University of Rochester by the NNSA/OICF under Agreement No. DE-FC52-08NA28302.

  11. Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats.

    Science.gov (United States)

    Vieira, C P; Guerra, F Da Ré; de Oliveira, L P; Almeida, M S; Marcondes, Maria Cristina Cintra; Pimentell, E R

    2015-02-01

    Green tea (GT) is widely used due to its anti-inflammatory properties. Previous studies have shown beneficial effects of a glycine diet on the remodeling process in inflamed tendons. Tendinitis is commonly observed in athletes and is of concern to surgeons due to the slowness of the recovery process. Our hypothesis is that GT + a glycine diet may improve tendinitis. To analyze the effect of GT and/or glycine in the diet on tendinitis. Wistar rats were divided into seven groups (G): control group (C); G1 and G4, tendinitis; G2 and G5, tendinitis supplied with GT; and G3 and G6, tendinitis supplied with GT and a glycine diet for 7 or 21 days, respectively. We performed zymography for metalloproteinase, biochemical, morphological and biomechanics tests. G2, G3 and G5 showed high levels of hydroxyproline in relation to G1, while G4 showed high levels of glycosaminoglycans. High activity of metalloproteinase-2 was detected in G3. The organization of collagen bundles was better in G2 and G3. G5 showed similar birefringence measurements compared with C. G5 withstood a larger load compared with G4. The presence of metalloproteinase-2 indicates that a tissue is undergoing a remodeling process. High birefringence suggests a better organization of collagen bundles. After 21 days, G5 sustained a high load before rupture, unlike G4. The results suggest that GT + a glycine diet has beneficial effects that aid in the recovery process of the tendon after tendinitis.

  12. Lifetime measurements of beauty hadrons at the LHCb experiment

    Energy Technology Data Exchange (ETDEWEB)

    Dordei, Francesca

    2015-05-19

    This thesis presents several lifetime measurements of b-flavoured hadrons at the LHCb experiment. They represent an important test of the theoretical approach to b-hadron observables known as Heavy Quark Expansion (HQE). This analysis uses data corresponding to an integrated luminosity of 1 fb{sup -1} collected in proton-proton collisions at a centre-of-mass energy of √(s)=7 TeV. For the decays B{sup +}→J/ψK{sup +}, B{sup 0}→J/ψK{sup *0}, B{sup 0}→J/ψK{sup 0}{sub S}, Λ{sup 0}{sub b}→J/ψΛ and B{sup 0}{sub s}→J/ψφ the lifetimes are measured to be τ{sub B{sup +}→J/ψK{sup +}}=1.637±0.004±0.003 ps, τ{sub B{sup 0}→J/ψK}{sup {sub *}{sub 0}}=1.524±0.006±0.004 ps, τ{sub B{sup 0}→J/ψK{sup 0}{sub S}}=1.499±0.013±0.005 ps, τ{sub Λ{sup 0}{sub b}} {sub →} {sub J/ψΛ}=1.415±0.027±0.006 ps, τ{sub B{sup 0}{sub s}} {sub →} {sub J/ψφ}=1.480±0.011±0.005 ps, where the first uncertainty is statistical and the second is systematic. These are the most precise lifetime measurements in these decay modes to date. Ratios of these lifetimes also are reported in this thesis, as they are well-defined quantities where many theoretical or experimental uncertainties cancel. The ratio of the decay width difference, ΔΓ{sub d}, to the average width, Γ{sub d}, in the B{sup 0} system is found to be ΔΓ{sub d}/Γ{sub d}=-0.044±0.025±0.011. Using data corresponding to an integrated luminosity of 3 fb{sup -1} collected at centre-of-mass energies of 7 TeV and 8 TeV, the measurements of the decay width difference, ΔΓ{sub s}, and the average width, Γ{sub s}, in the B{sup 0}{sub s} system are performed. Using the decay B{sup 0}{sub s}→J/ψφ, they are measured to be ΔΓ{sub s}=0.0805±0.0091±0.0033 ps{sup -1}, Γ{sub s}=0.6603±0.0027±0.0015 ps{sup -1}. These are the most precise determinations of these observables ot date. All measurements are consistent with HQE predictions.

  13. Neutron Measurements in Small MagLIF Experiments on OMEGA

    Science.gov (United States)

    Glebov, V. Yu.; Barnak, D. H.; Davies, J. R.; Knauer, J. P.; Betti, R.; Regan, S. P.; Sangster, T. C.; Campbell, E. M.

    2016-10-01

    The Laboratory for Laser Energetics (LLE) is participating in laser-driven magnetized linear inertial fusion (MagLIF) research on the OMEGA Laser System in partnership with Sandia as part of ARPA-E's ALPHA Program. In the current OMEGA setup, a CH cylindrical tube filled with D2 gas is compressed by 40 laser beams, preheated by one of the beams, and an axial magnetic field is applied to limit electron heat loss. Two copper coils provide 10-T magnetic fields. A neutron time-of-flight (nTOF) detector has been designed, fabricated, and calibrated to diagnose primary D-D fusion neutron yield in the range of 1 ×107 to 5 ×109 and ion temperature from 2 to 8 keV. The design details and calibration results of these nTOF detectors will be presented together with neutron measurement results from recent laser-driven MagLIF experiments on OMEGA. The information, data, or work presented herein was funded in part by the Advanced Research Projects Agency-Energy (ARPA-E), U.S. Department of Energy, under Award Number DE-AR0000568, and the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  14. Measuring Networking as an Outcome Variable in Undergraduate Research Experiences

    Science.gov (United States)

    Hanauer, David I.; Hatfull, Graham

    2015-01-01

    The aim of this paper is to propose, present, and validate a simple survey instrument to measure student conversational networking. The tool consists of five items that cover personal and professional social networks, and its basic principle is the self-reporting of degrees of conversation, with a range of specific discussion partners. The networking instrument was validated in three studies. The basic psychometric characteristics of the scales were established by conducting a factor analysis and evaluating internal consistency using Cronbach’s alpha. The second study used a known-groups comparison and involved comparing outcomes for networking scales between two different undergraduate laboratory courses (one involving a specific effort to enhance networking). The final study looked at potential relationships between specific networking items and the established psychosocial variable of project ownership through a series of binary logistic regressions. Overall, the data from the three studies indicate that the networking scales have high internal consistency (α = 0.88), consist of a unitary dimension, can significantly differentiate between research experiences with low and high networking designs, and are related to project ownership scales. The ramifications of the networking instrument for student retention, the enhancement of public scientific literacy, and the differentiation of laboratory courses are discussed. PMID:26538387

  15. Experiment to measure oxygen opacity at high density and temperature

    Science.gov (United States)

    Keiter, Paul; Butler, Hannah; Trantham, Matt; Mussack, Katie; Colgan, James; Fontes, Chris; Guzik, Joyce; Kilcrease, David; Perry, Ted; Orban, Chris; Ducret, Jean-Eric; La Pennec, Maelle; Turck-Chieze, Sylvaine; Mancini, Roberto; Heeter, Robert

    2017-10-01

    In recent years, there has been a debate over the abundances of heavy elements (Z >2) in the solar interior. Recent solar atmosphere models [Asplund 2009] find a significantly lower abundance for C, N, and O compared to models used roughly a decade ago. Recent opacity measurements of iron disagree with opacity model predictions [Bailey et al., 2015]. Repeated scrutiny of the experiment and data has not produced a conclusive reason for the discrepancy. New models have been implemented in the ATOMIC opacity code for low-Z elements [Colgan, 2013, Armstrong 2014], however no data currently exists to test the low-Z material models in the regime relevant to the solar convection zone. We present an experimental design using the opacity platform developed at the National Ignition Facility to study the oxygen opacity at densities and temperatures near the solar convection zone conditions. This work is funded by the U.S. DOE, through the NNSA-DS and SC-OFES Joint Program in HEDLP, Grant Number DE-NA0002956, and the NLUF Program, Grant Number DE-NA0002719, and through the LLE, University of Rochester by the NNSA/OICF under No. DE-NA0001944.

  16. Muon polarization in the MEG experiment: predictions and measurements

    Energy Technology Data Exchange (ETDEWEB)

    Baldini, A.M.; Dussoni, S.; Galli, L.; Grassi, M.; Sergiampietri, F.; Signorelli, G. [Pisa Univ. (Italy); INFN Sezione di Pisa, Pisa (Italy); Bao, Y.; Hildebrandt, M.; Kettle, P.R.; Mtchedlishvili, A.; Papa, A.; Ritt, S. [Paul Scherrer Institut PSI, Villigen (Switzerland); Baracchini, E. [University of Tokyo, ICEPP, Tokyo (Japan); INFN, Laboratori Nazionali di Frascati, Rome (Italy); Bemporad, C.; Cei, F.; D' Onofrio, A.; Nicolo, D.; Tenchini, F. [INFN Sezione di Pisa, Pisa (Italy); Pisa Univ., Dipartimento di Fisica, Pisa (Italy); Berg, F.; Hodge, Z.; Rutar, G. [Paul Scherrer Institut PSI, Villigen (Switzerland); Swiss Federal Institute of Technology ETH, Zurich (Switzerland); Biasotti, M.; Gatti, F.; Pizzigoni, G. [INFN Sezione di Genova, Genova (Italy); Genova Univ., Dipartimento di Fisica, Genova (Italy); Boca, G.; De Bari, A. [INFN Sezione di Pavia, Pavia (Italy); Pavia Univ., Dipartimento di Fisica, Pavia (Italy); Cattaneo, P.W.; Rossella, M. [Pavia Univ. (Italy); INFN Sezione di Pavia, Pavia (Italy); Cavoto, G.; Piredda, G.; Renga, F.; Voena, C. [Univ. ' ' Sapienza' ' , Rome (Italy); INFN Sezione di Roma, Rome (Italy); Chiarello, G.; Panareo, M.; Pepino, A. [INFN Sezione di Lecce, Lecce (Italy); Univ. del Salento, Dipartimento di Matematica e Fisica, Lecce (Italy); Chiri, C.; Grancagnolo, F.; Tassielli, G.F. [Univ. del Salento (Italy); INFN Sezione di Lecce, Lecce (Italy); De Gerone, M. [Genova Univ. (Italy); INFN Sezione di Genova, Genova (Italy); Fujii, Y.; Iwamoto, T.; Kaneko, D.; Mori, Toshinori; Nakaura, S.; Nishimura, M.; Ogawa, S.; Ootani, W.; Sawada, R.; Uchiyama, Y.; Yoshida, K. [University of Tokyo, ICEPP, Tokyo (Japan); Graziosi, A.; Ripiccini, E. [INFN Sezione di Roma, Rome (Italy); Univ. ' ' Sapienza' ' , Dipartimento di Fisica, Rome (Italy); Grigoriev, D.N. [Budker Institute of Nuclear Physics of Siberian Branch of Russian Academy of Sciences, Novosibirsk (Russian Federation); Novosibirsk State Technical University, Novosibirsk (Russian Federation); Novosibirsk State University, Novosibirsk (Russian Federation); Haruyama, T.; Mihara, S.; Nishiguchi, H.; Yamamoto, A. [KEK, High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan); Ieki, K. [Paul Scherrer Institut PSI, Villigen (Switzerland); University of Tokyo, ICEPP, Tokyo (Japan); Ignatov, F.; Khazin, B.I.; Popov, A.; Yudin, Yu.V. [Budker Institute of Nuclear Physics of Siberian Branch of Russian Academy of Sciences, Novosibirsk (Russian Federation); Novosibirsk State University, Novosibirsk (Russian Federation); Kang, T.I.; Lim, G.M.A.; Molzon, W.; You, Z. [University of California, Irvine, CA (United States); Khomutov, N.; Korenchenko, A.; Kravchuk, N. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Venturini, M. [Pisa Univ. (Italy); INFN Sezione di Pisa, Pisa (Italy); Scuola Normale Superiore, Pisa (Italy); Collaboration: The MEG Collaboration

    2016-04-15

    The MEG experiment makes use of one of the world's most intense low energy muon beams, in order to search for the lepton flavour violating process μ{sup +} → e{sup +}γ. We determined the residual beam polarization at the thin stopping target, by measuring the asymmetry of the angular distribution of Michel decay positrons as a function of energy. The initial muon beam polarization at the production is predicted to be P{sub μ} = -1 by the Standard Model (SM) with massless neutrinos. We estimated our residual muon polarization to be P{sub μ} =.0.86 ± 0.02 (stat){sub -0.06}{sup +0.05} (syst) at the stopping target, which is consistent with the SM predictions when the depolarizing effects occurring during the muon production, propagation and moderation in the target are taken into account. The knowledge of beam polarization is of fundamental importance in order to model the background of our μ{sup +} → e{sup +}γ search induced by the muon radiative decay: μ{sup +} → e{sup +} anti ν{sub μ}ν{sub e}γ. (orig.)

  17. Flowing dusty plasma experiments: Generation of flow and measurement techniques

    CERN Document Server

    Jaiswal, S; Sen, A

    2016-01-01

    A variety of experimental techniques for the generation of subsonic/supersonic dust fluid flows and means of measuring such flow velocities are presented. The experiments have been carried out in a $\\Pi-$shaped Dusty Plasma Experimental (DPEx) device with micron size kaolin/Melamine Formaldehyde (MF) particles embedded in a background of Argon plasma created by a direct current (DC) glow discharge. A stationary dust cloud is formed over the cathode region by precisely balancing the pumping speed and gas flow rate. A flow of dust particles/fluid is generated by additional gas injection from a single or dual locations or by altering the dust confining potential. The flow velocity is then estimated by three different techniques, namely, by super Particle Identification (sPIT) code, Particle Image Velocimetry (PIV) analysis and the excitation of Dust Acoustic Waves (DAWs). The results obtained from these three different techniques along with their merits and demerits are discussed. An estimation of the neutral dr...

  18. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia.

    Directory of Open Access Journals (Sweden)

    J Pedro Fernández-Murray

    2016-01-01

    Full Text Available Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell precursors. A common subtype of congenital sideroblastic anemia is due to autosomal recessive mutations in the SLC25A38 gene. The current treatment for SLC25A38 congenital sideroblastic anemia is chronic blood transfusion coupled with iron chelation. The function of SLC25A38 is not known. Here we report that the SLC25A38 protein, and its yeast homolog Hem25, are mitochondrial glycine transporters required for the initiation of heme synthesis. To do so, we took advantage of the fact that mitochondrial glycine has several roles beyond the synthesis of heme, including the synthesis of folate derivatives through the glycine cleavage system. The data were consistent with Hem25 not being the sole mitochondrial glycine importer, and we identify a second SLC25 family member Ymc1, as a potential secondary mitochondrial glycine importer. Based on these findings, we observed that high levels of exogenous glycine, or 5-aminolevulinic acid (5-Ala a metabolite downstream of Hem25 in heme biosynthetic pathway, were able to restore heme levels to normal in yeast cells lacking Hem25 function. While neither glycine nor 5-Ala could ameliorate SLC25A38 congenital sideroblastic anemia in a zebrafish model, we determined that the addition of folate with glycine was able to restore hemoglobin levels. This difference is likely due to the fact that yeast can synthesize folate, whereas in zebrafish folate is an essential vitamin that must be obtained exogenously. Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia.

  19. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia.

    Science.gov (United States)

    Fernández-Murray, J Pedro; Prykhozhij, Sergey V; Dufay, J Noelia; Steele, Shelby L; Gaston, Daniel; Nasrallah, Gheyath K; Coombs, Andrew J; Liwski, Robert S; Fernandez, Conrad V; Berman, Jason N; McMaster, Christopher R

    2016-01-01

    Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell precursors. A common subtype of congenital sideroblastic anemia is due to autosomal recessive mutations in the SLC25A38 gene. The current treatment for SLC25A38 congenital sideroblastic anemia is chronic blood transfusion coupled with iron chelation. The function of SLC25A38 is not known. Here we report that the SLC25A38 protein, and its yeast homolog Hem25, are mitochondrial glycine transporters required for the initiation of heme synthesis. To do so, we took advantage of the fact that mitochondrial glycine has several roles beyond the synthesis of heme, including the synthesis of folate derivatives through the glycine cleavage system. The data were consistent with Hem25 not being the sole mitochondrial glycine importer, and we identify a second SLC25 family member Ymc1, as a potential secondary mitochondrial glycine importer. Based on these findings, we observed that high levels of exogenous glycine, or 5-aminolevulinic acid (5-Ala) a metabolite downstream of Hem25 in heme biosynthetic pathway, were able to restore heme levels to normal in yeast cells lacking Hem25 function. While neither glycine nor 5-Ala could ameliorate SLC25A38 congenital sideroblastic anemia in a zebrafish model, we determined that the addition of folate with glycine was able to restore hemoglobin levels. This difference is likely due to the fact that yeast can synthesize folate, whereas in zebrafish folate is an essential vitamin that must be obtained exogenously. Given the tolerability of glycine and folate in humans, this study points to a potential novel treatment for SLC25A38 congenital sideroblastic anemia.

  20. Measuring Networking as an Outcome Variable in Undergraduate Research Experiences.

    Science.gov (United States)

    Hanauer, David I; Hatfull, Graham

    2015-01-01

    The aim of this paper is to propose, present, and validate a simple survey instrument to measure student conversational networking. The tool consists of five items that cover personal and professional social networks, and its basic principle is the self-reporting of degrees of conversation, with a range of specific discussion partners. The networking instrument was validated in three studies. The basic psychometric characteristics of the scales were established by conducting a factor analysis and evaluating internal consistency using Cronbach's alpha. The second study used a known-groups comparison and involved comparing outcomes for networking scales between two different undergraduate laboratory courses (one involving a specific effort to enhance networking). The final study looked at potential relationships between specific networking items and the established psychosocial variable of project ownership through a series of binary logistic regressions. Overall, the data from the three studies indicate that the networking scales have high internal consistency (α = 0.88), consist of a unitary dimension, can significantly differentiate between research experiences with low and high networking designs, and are related to project ownership scales. The ramifications of the networking instrument for student retention, the enhancement of public scientific literacy, and the differentiation of laboratory courses are discussed. © 2015 D. I. Hanauer and G. Hatfull. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  1. Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists

    DEFF Research Database (Denmark)

    Mohsen, Amal M Y; Mandour, Yasmine M; Sarukhanyan, Edita

    2016-01-01

    A series of (E)-11-isonitrosostrychnine oxime ethers, 2-aminostrychnine, (strychnine-2-yl)propionamide, 18-oxostrychnine, and N-propylstrychnine bromide were synthesized and evaluated pharmacologically at human α1 and α1β glycine receptors in a functional fluorescence-based and a whole-cell patch......-clamp assay and in [(3)H]strychnine binding studies. 2-Aminostrychnine and the methyl, allyl, and propargyl oxime ethers were the most potent α1 and α1β antagonists in the series, displaying IC50 values similar to those of strychnine at the two receptors. Docking experiments to the strychnine binding site...... of the crystal structure of the α3 glycine receptor indicated the same orientation of the strychnine core for all analogues. For the most potent oxime ethers, the ether substituent was accommodated in a lipophilic receptor binding pocket. The findings identify the oxime hydroxy group as a suitable attachment...

  2. New Molybdenum Epoxidation Catalyst Derived From Nanoporous MCM-41 Supported Glycine Schiff-Base

    Directory of Open Access Journals (Sweden)

    M. Masteri-Farahani

    2012-03-01

    Full Text Available Covalent grafting of the nanoporous molecular sieve MCM-41 with 3- aminopropyl trimethoxysilane and acetyl acetone (acac successively gave modified MCM-41 (acacAmpMCM-41. Reaction of the resulted material with glycine afforded the corresponding supported glycine Schiff base ligand and subsequent reaction with [bis(acetylacetonatodioxomolybdenum(VI] was lead to molybdenum complex supported on MCM-41 through propyl chain spacer. Characterization of the resulting material was carried out with FT-IR, atomic absorption spectroscopy, powder X-ray diffraction and BET nitrogen sorption methods. The XRD and BET analyses revealed that textural properties of support were preserved during the grafting experiments. The resulted material successfully catalyzed the epoxidation of olefins with  tert-butyl hydroperoxide to the corresponding epoxides.

  3. Development of Heterodera glycines on Soybean Damaged by Soybean Looper and Stem Canker.

    Science.gov (United States)

    Russin, J S; Layton, M B; Boethel, D J; McGawley, E C; Snow, J P; Berggren, G T

    1989-01-01

    Short-term greenhouse studies with soybean (Glycine max cv. Bragg) were used to examine interactions between the soybean cyst nematode (Heterodera glycines) and two other common pests of soybean, the stem canker fungus (Diaporthe phaseolorum var. caulivora) and the soybean looper (Pseudoplusia includens), a lepidopterous defoliator. Numbers of cyst nematode juveniles in roots and numbers of cysts in soil and roots were reduced on plants with stem cankers. Defoliation by soybean looper larvae had the opposite effect; defoliation levels of 22 and 64% caused stepwise increases in numbers of juveniles and cysts in both roots and soil, whereas numbers of females in roots decreased. In two experiments, stem canker length was reduced 40 and 45% when root systems were colonized by the soybean cyst nematode. The absence of significant interactions among these pests indicates that the effects of soybean cyst nematode, stem canker, and soybean looper on plant growth and each other primarily were additive.

  4. [Endophytic bacterial diversity of wild soybean (Glycine soja) varieties with different resistance to soybean cyst nematode (Heterodera glycines)].

    Science.gov (United States)

    Wu, Yunpeng; Shi, Fengyu; Hamid, M Imran; Zhu, Yingbo

    2014-08-04

    The aim of this study was to investigate endophytic bacterial diversity of wild soybean varieties with different resistance to soybean cyst nematode(Heterodera glycines) , for deciphering the interactions of soybean cyst nematode with endophytic bacteria. After screening wild soybean varieties against race 3 of H. glycines, we investigated endophytic bacterial diversity in root tissues of wild soybean varieties with different resistance to H. glycines using 16S rDNA cloning library and amplified ribosomal DNA restriction analysis. Endophytic bacteria of wild soybean root belonged to 6 bacterial groups, the clones belonging to group Proteobacteria and Firmicutes were the endophyte dominants in wild soybean with 46.8% and 13.6% of total clones, respectively. Actinobacteria, Bacteroidetes, Acidobacteria, Deincoccus-Thermus and Archaea were less represented. 18.8% of clone sequences were similar to those of uncultured bacteria in the environment. The bacterial diversity was higher in H. glycines-Resistant than -Susceptible wild soybean varieties, and the dominant group was different between H. glycines-Resistant and -Susceptible wild soybean varieties. Mesorhizobium tamadayense, Enterobacter ludwigii and Bacillus megaterium were the main bacterial groups in special operational taxonomic units (OTUs) of H. glycines-Resistant wild soybean variety. By 16S rDNA cloning library and amplified ribosomal DNA restriction analysis, the diversity of dominant group of endophytic bacteria in root tissues has difference among H. glycines-Resistant and -Susceptible wild soybean varieties.

  5. Nanomolar Levels of Dimethylsulfoniopropionate, Dimethylsulfonioacetate, and Glycine Betaine Are Sufficient To Confer Osmoprotection to Escherichia coli

    OpenAIRE

    Cosquer, Anne; Pichereau, Vianney; Pocard, Jean-Alain; Minet, Jacques; Cormier, Michel; Bernard, Théophile

    1999-01-01

    We combined the use of low inoculation titers (300 ± 100 CFU/ml) and enumeration of culturable cells to measure the osmoprotective potentialities of dimethylsulfoniopropionate (DMSP), dimethylsulfonioacetate (DMSA), and glycine betaine (GB) for salt-stressed cultures of Escherichia coli. Dilute bacterial cultures were grown with osmoprotectant concentrations that encompassed the nanomolar levels of GB and DMSP found in nature and the millimolar levels of osmoprotectants used in standard labor...

  6. The Bolund experiment - design of measurement campaign using CFD

    DEFF Research Database (Denmark)

    Bechmann, Andreas; Johansen, Jeppe; Sørensen, Niels N.

    the upcoming measurement campaign. The simulation results are used for estimating rational positions of measuring masts and instrumentation. A total of ten measuring masts are proposed consisting of two 16 m masts, six 9 m masts and two 5 m masts. The masts are instrumented with 12 cup anemometers for mean...

  7. Comparative analysis of complete plastid genomes from wild soybean (Glycine soja) and nine other Glycine species.

    Science.gov (United States)

    Asaf, Sajjad; Khan, Abdul Latif; Aaqil Khan, Muhammad; Muhammad Imran, Qari; Kang, Sang-Mo; Al-Hosni, Khdija; Jeong, Eun Ju; Lee, Ko Eun; Lee, In-Jung

    2017-01-01

    The plastid genomes of different plant species exhibit significant variation, thereby providing valuable markers for exploring evolutionary relationships and population genetics. Glycine soja (wild soybean) is recognized as the wild ancestor of cultivated soybean (G. max), representing a valuable genetic resource for soybean breeding programmes. In the present study, the complete plastid genome of G. soja was sequenced using Illumina paired-end sequencing and then compared it for the first time with previously reported plastid genome sequences from nine other Glycine species. The G. soja plastid genome was 152,224 bp in length and possessed a typical quadripartite structure, consisting of a pair of inverted repeats (IRa/IRb; 25,574 bp) separated by small (178,963 bp) and large (83,181 bp) single-copy regions, with a 51-kb inversion in the large single-copy region. The genome encoded 134 genes, including 87 protein-coding genes, eight ribosomal RNA genes, and 39 transfer RNA genes, and possessed 204 randomly distributed microsatellites, including 15 forward, 25 tandem, and 34 palindromic repeats. Whole-plastid genome comparisons revealed an overall high degree of sequence similarity between G. max and G. gracilis and some divergence in the intergenic spacers of other species. Greater numbers of indels and SNP substitutions were observed compared with G. cyrtoloba. The sequence of the accD gene from G. soja was highly divergent from those of the other species except for G. max and G. gracilis. Phylogenomic analyses of the complete plastid genomes and 76 shared genes yielded an identical topology and indicated that G. soja is closely related to G. max and G. gracilis. The complete G. soja genome sequenced in the present study is a valuable resource for investigating the population and evolutionary genetics of Glycine species and can be used to identify related species.

  8. Effects of Some Pesticides on the Growth of ARF18 and Its Pathogenicity to Heterodera glycines

    Science.gov (United States)

    Kim, D. G.; Riggs, R. D.

    1998-01-01

    The effects of 22 pesticides on the mycelial growth and pathogenicity of the biocontrol fungus ARFI8 to Heterodera glycines were tested in vitro. The chemicals were added to agar at 10, 100, and 1,000 ppm a.i.; a block of agar containing the fungus was added to each test concentration; and fungal growth was measured. Subsequently, a block of the fungus on the pesticide-containing agar was used to determine the ability of the fungus to parasitize eggs of H. glycines. Aldicarb, bentazone, and chlorothalonil had little or no effect on fungal growth, whereas benomyl and thiophanate methyl completely inhibited growth of the fungus at 10 ppm. The relative insensitivity of ARF18 to certain pesticides would permit selected use of those pesticides with ARF18 in an integrated control program if the effects on the fungus in the field are similar to results from petri dish studies. PMID:19274211

  9. Effect of CO2 Concentration on Glycine and Serine Formation during Photorespiration 1

    Science.gov (United States)

    Snyder, F. W.; Tolbert, N. E.

    1974-01-01

    Amount and products of photosynthesis during 10 minutes were measured at different 14CO2 concentrations in air. With tobacco (Nicotiana tabacum L. cv. Maryland Mammoth) leaves the percentage of 14C in glycine plus serine was highest (42%) at 0.005% CO2, and decreased with increasing CO2 concentration to 7% of the total at 1% CO2 in air. However, above 0.03% CO2 the total amount of 14C incorporated into the glycine and serine pool was about constant. At 0.005% or 0.03% CO2 the percentage and amount of 14C in sucrose was small but increased greatly at higher CO2 levels as sucrose accumulated as an end product. Relatively similar data were obtained with sugar beet (Beta vulgaris L. cv. US H20) leaves. The results suggest that photorespiration at high CO2 concentration is not inhibited but that CO2 loss from it becomes less significant. PMID:16658736

  10. Validation of ozone measurements from the Atmospheric Chemistry Experiment (ACE)

    National Research Council Canada - National Science Library

    ...; Dupuy, E; Walker, K. A; Kar, J; Boone, C. D; McElroy, C. T; Bernath, P. F; Drummond, J. R; Skelton, R; McLeod, S. D; Hughes, R. C; Nowlan, C. R; Dufour, D. G; Zou, J; Nichitiu, F; Strong, K; Baron, P; Bevilacqua, R. M; Blumenstock, T; Bodeker, G. E; Borsdorff, T; Bourassa, A. E; Bovensmann, H; Boyd, I. S; Bracher, A; Brogniez, C; Burrows, J. P; Catoire, V; Ceccherini, S; Chabrillat, S; Christensen, T; Coffey, M. T; Cortesi, U; Davies, J; De Clercq, C; Degenstein, D. A; De Mazière, M; Demoulin, P; Dodion, J; Firanski, B; Fischer, H; Forbes, G; Froidevaux, L; Fussen, D; Gerard, P; Godin-Beekmann, S; Goutail, F; Granville, J; Griffith, D; Haley, C. S; Hannigan, J. W; Höpfner, M; Jin, J. J; Jones, A; Jones, N. B; Jucks, K; Kagawa, A; Kasai, Y; Kerzenmacher, T. E; Kleinböhl, A; Klekociuk, A. R; Kramer, I; Küllmann, H; Kuttippurath, J; Kyrölä, E; Lambert, J.-C; Livesey, N. J; Llewellyn, E. J; Lloyd, N. D; Mahieu, E; Manney, G. L; Marshall, B. T; McConnell, J. C; McCormick, M. P; McDermid, I. S; McHugh, M; McLinden, C. A; Mellqvist, J; Mizutani, K; Murayama, Y; Murtagh, D. P; Oelhaf, H; Parrish, A; Petelina, S. V; Piccolo, C; Pommereau, J.-P; Randall, C. E; Robert, C; Roth, C; Schneider, M; Senten, C; Steck, T; Strandberg, A; Strawbridge, K. B; Sussmann, R; Swart, D. P. J; Tarasick, D. W; Taylor, J. R; Tétard, C; Thomason, L. W; Thompson, A. M

    2009-01-01

    ...) satellite instruments: the ACE Fourier Transform Spectrometer (ACE-FTS) and the Measurement of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation (ACE-MAESTRO) instrument...

  11. Proline, glycine betaine, total phenolics and pigment contents in response to osmotic stress in maize seedlings

    Directory of Open Access Journals (Sweden)

    SAJJAD MOHARRAMNEJAD

    2015-12-01

    Full Text Available In order to evaluate the fresh weight, RWC, pigment content, total phenolics, proline and glycine betaine responses of maize inbred lines to osmotic stress, a factorial experiment was carried out under laboratory conditions with two maize inbred lines (B73 and MO17 and two osmotic stress levels induced by PEG (control and -0.6 MPa. Fresh weight significantly decreased under drought stress. On the basis of percent inhibition in fresh weight at the osmotic stress MO17 was ranked as tolerant (inhibition 45.30%, and B73 drought sensitive (inhibition more than 50%. Leaf relative water content (RWC was significantly decreased in both inbred lines under osmotic stress. The pigment concentrations were substantially declined in both maize inbreds under osmotic stressed conditions. However, this reduction was less in B73 than MO17. Osmoitc stress declined the levels of total phenolics in both maize inbreds. On the other hand, the osmotic stress markedly enhanced the levels of proline and glycine betaine in both maize inbreds, but this was more pronounced in MO17. The present results showed that osmotic stress retards the growth and some biochemical attributes of maize inbreds. In conclusion, the level of proline and glycine betaine in maize could improve drought tolerance.

  12. Intra-operative parathyroid hormone measurementsexperience of ...

    African Journals Online (AJOL)

    Background. Surgery is the treatment of choice for symptomatic primary hyperparathyroidism. The majority of research concerning intra-operative parathyroid hormone (ioPTH) measurements is conducted in university hospitals. Whether ioPTH measurements are feasible and useful in predicting the presence of remaining ...

  13. Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure.

    Directory of Open Access Journals (Sweden)

    Tomonobu M Watanabe

    Full Text Available Fluorescent protein-based indicators for intracellular environment conditions such as pH and ion concentrations are commonly used to study the status and dynamics of living cells. Despite being an important factor in many biological processes, the development of an indicator for the physicochemical state of water, such as pressure, viscosity and temperature, however, has been neglected. We here found a novel mutation that dramatically enhances the pressure dependency of the yellow fluorescent protein (YFP by inserting several glycines into it. The crystal structure of the mutant showed that the tyrosine near the chromophore flipped toward the outside of the β-can structure, resulting in the entry of a few water molecules near the chromophore. In response to changes in hydrostatic pressure, a spectrum shift and an intensity change of the fluorescence were observed. By measuring the fluorescence of the YFP mutant, we succeeded in measuring the intracellular pressure change in living cell. This study shows a new strategy of design to engineer fluorescent protein indicators to sense hydrostatic pressure.

  14. Glycine: A potential coupling agent to bond to helium plasma treated PEEK?

    Science.gov (United States)

    Schmidlin, Patrick R; Eichberger, Marlis; Stawarczyk, Bogna

    2016-02-01

    To test the tensile bond strength (TBS) between two self-adhesive resin composite cements and PEEK after helium plasma treatment and used glycine as a potential coupling agent incorporated in different adhesives. In summary, 896 air-abraded PEEK specimens were fabricated. Half of the specimens were treated with cold active inert helium plasma and the other half were left non-treated. Both groups were then split in two groups: In group 1 (n=256), 64 specimens were pre-treated with: (a) soft-liner liquid, (b) visio.link, (c) Ambarino P60 and (d) no pre-treatment (control), respectively. In group 2 (n=192), specimens were conditioned accordingly, but the adhesive materials were modified by including a commercially available glycine (Air-Flow PERIO). PEEK specimens were then luted using either RelyX Unicem or Clearfil SA Cement and TBS was measured initially and after 14 days water storage combined with 10'000 thermal cycles (16 specimens/subgroup). Fracture type analysis was performed. For statistical analyses Kolmogorov-Smirnov, Shapiro-Wilk tests, 1-, 4-way ANOVA (post hoc: Scheffé), and t-test were used (p0.348). In contrast, a combination between glycine application and Softline/Ambarino P60 allowed for significantly higher initial TBS was measured after helium plasma treatment (p=0.001). However, this effect was no evident after thermo-cycling. All groups conditioned with visio.link showed the highest TBS values. The introduction of amine groups by simple provision of amino acids in the form of glycine can improve the bond strength after helium plasma treatment using different adhesive materials. However, using this simple approach, the method cannot withstand thermal challenge yet. Copyright © 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  15. Measuring the Quality of the Website User Experience

    Science.gov (United States)

    Sauro, Jeff

    2016-01-01

    Consumers spend an increasing amount of time and money online finding information, completing tasks, or making purchases. The quality of the website experience has become a key differentiator for organizations--affecting whether they purchase and their likelihood to return and recommend a website to friends. Two instruments were created to more…

  16. Measuring Customer Experience in Bancassurance: An Empirical Study

    Directory of Open Access Journals (Sweden)

    Mousumi Choudhury

    2016-06-01

    Full Text Available Purpose – This study attempts to investigate customer experience with respect to the bancassurance channel. Design/Methodology/Approach – The study is based on primary data collected using a structured questionnaire from customers buying life insurance policies from SBI Life through different branches of State Bank of India in the city of Guwahati in the state of Assam, India. Cronbach’s alpha was used to test the reliability of the questionnaire. Statistical tools, such as mean, standard deviation, and factor analysis were used to attain the objective of the study. Findings and implications – The study found that customers have favorable experiences when buying life insurance through the bancassurance channel. There are seven core factors that affect customer experience in bancassurance: ease of buying, whether maturity benefit is received, reliability of the channel, responsiveness of the channel, after-sale services, stock market-related information, and accuracy of the channel. Banks should devise a strategy to sustain favorable experiences of their customers, as this enables banks to retain their existing customers while also attracting new ones. Limitation – The study is restricted to customers buying life insurance policy from various branches of State Bank of India in Guwahati, India. Therefore, longitudinal and cross-sectional research is needed to generalize the findings. Originality – The study is first of its kind and hence original in nature.

  17. ESADA Plutonium Program Critical Experiments: Power Distribution Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Akkurt, H.

    2001-06-12

    In 1967, a series of critical experiments were conducted at the Westinghouse Reactor Evaluation Center (WREC) using mixed-oxide (MOX) PuO{sub 2}-UO{sub 2} and/or UO{sub 2} fuels in various lattices and configurations. These experiments were performed under the joint sponsorship of Empire State Atomic Development Associates (ESADA) plutonium program and Westinghouse. The purpose of these experiments was to develop experimental data useful in validating analytical methods used in the design of plutonium-bearing replacement fuel for water reactors. Three different fuel types were used during the experimental program: two MOX fuels and a low-enriched UO{sub 2} fuel. The MOX fuels were distinguished by their {sup 240}Pu content: 8 wt % {sup 240}Pu and 24 wt % {sup 240}Pu. Both MOX fuels contained 2.0 wt % PuO{sub 2} in natural UO{sub 2}. The UO{sub 2} fuel with 2.72 wt % enrichment was used for comparison with the plutonium data and for use in multiregion experiments.

  18. Measuring Client Experiences of Motivational Interviewing during a Lifestyle Intervention

    Science.gov (United States)

    Madson, Michael B.; Mohn, Richard S.; Schumacher, Julie A.; Landry, Alicia S.

    2015-01-01

    The Client Evaluation of Motivational Interviewing was used to assess motivational interviewing experiences in a predominantly female, African American sample from the Southeastern United States who received motivational interviewing-based feedback during a multicomponent lifestyle intervention. Motivational interviewing was experienced…

  19. Identification of microRNAs in wild soybean (Glycine soja).

    Science.gov (United States)

    Chen, Rui; Hu, Zheng; Zhang, Hui

    2009-12-01

    MicroRNAs (miRNAs) play important roles in post-transcriptional gene silencing by directing target mRNA cleavage or translational inhibition. Currently, hundreds of miRNAs have been identified in plants, but no report has been published of wild soybean (Glycine soja Sieb). We constructed a small-RNA library consisting of 2 880 sequences with high quality, in which 1 347 were 19-24 nt in length. By utilizing the miRNA, Rfam and domesticated soybean expressed sequence tag database, we have analyzed and predicted the secondary structure of these small RNAs. As a result, 15 conserved miRNA candidates belonging to eight different families and nine novel miRNA candidates comprising eight families were identified in wild soybean seedlings. All these miRNA candidates were validated by northern blot and the novel candidates expressed in a tissue-specific manner. Furthermore, putative target genes were predicted for novel miRNA candidates and two of them were verified by 5'-rapid amplification of cDNA ends experiments. These results provided useful information for miRNA research in wild soybean and plants.

  20. Measuring User Experience of the Student-Centered e-Learning Environment

    Science.gov (United States)

    Santoso, Harry B.; Schrepp, Martin; Isal, R. Yugo Kartono; Utomo, Andika Yudha; Priyogi, Bilih

    2016-01-01

    The aim of the current study is to develop an adapted version of User Experience Questionnaire (UEQ) and evaluate a learning management system. Although there is a growing interest on User Experience, there are still limited resources (i.e. measurement tools or questionnaires) available to measure user experience of any products, especially…

  1. How Good is Your User Experience? Measuring and Designing Interactions

    Directory of Open Access Journals (Sweden)

    Wildner Raimund

    2015-11-01

    Full Text Available Form and function are important dimensions of consumer choice, but there is more in our increasingly digital world. It is not only products per se that need to be designed but the whole interaction between consumers and brands. The whole UX or user experience is more important than ever before. Digitalism nowadays is everywhere, and even mundane products are becoming more digital (e.g. ovens, while others evolve that are purely digital (e.g. PayPal.

  2. [Patient reported outcome measures in geriatric care: first experiences].

    Science.gov (United States)

    Hems, Marleen; Harkes, Marleen; Moret-Hartman, Margriet; Melis, René J F; Schoon, Yvonne

    2017-12-01

    There are difficulties in expressing the value of geriatric care in outcome measures such as recovery or mortality rates. Rather, the goal of geriatric care is to maintain quality of life and functionality. As such, patient reported outcome measures (PROMs) may be more effective in measuring the value healthcare creates in geriatric patients. In 2015 the Dutch Geriatrics Society asked their Committee Quality of Care Measurement to select a suitable PROM for the purpose of measuring the outcomes of geriatric hospital care. The goal of this PROM is to measure outcomes of an hospital admission in the perspective of the elderly patient who was admitted to a geriatric ward. A group of caregivers in geriatric care identified four possible PROMs in the literature and based on selection criteria the TOPICS-MDS was chosen as most suitable. To increase the feasibility of implementation in daily practice, an item reduction study was performed and this resulted in a short form: TOPICS-SF. Two pilot studies in three hospitals took place on a geriatric ward. A response of 62% was observed during the first pilot with TOPICS-MDS and a response of 37% was observed during the second pilot with TOPICS-SF. The Katz-15 improved during hospital stay and during one month at home after discharge. The TOPICS-SF has been selected as PROM for the older patient receiving geriatric care and is feasible in practice. More research in different settings and with different moments of measurements is needed to evaluate the responsiveness of TOPICS-SF and the conditions for feasible implementation in daily practice.

  3. Effect of Glycine Betaine and Salicylic Acid on Growth and Productivity of Droughted Wheat Cultivars: Image Analysis for Measuring the Anatomical Features in Flag Leaf and Peduncle of the Main Shoot

    Directory of Open Access Journals (Sweden)

    Aldesuquy, Heshmat S.

    2013-04-01

    Full Text Available The present study was planned to investigate the possible role displayed by water stress and application of GB, SA or their interaction on some anatomical features in flag leaf at anthesis (after 95 days from sowing by measuring leaf thickness, ground tissue thickness, number of hairs, metaxylem vessel area, xylem vessel area, phloem tissue area, vascular bundle tissues area, number of motor cells as well as number of opened and closed stomata on both upper and lower epidermis and some anatomical features of peduncle (peduncle diameter, tracheids area, metaxylem vessel area, xylem area, phloem area, vascular area, number of vascular bundle as well as opened and closed stomata of the two wheat cultivars. Water stress markedly affected the anatomical features in flag leaves of both wheat cultivars. It caused massive decreases (P< 0.05 in the leaf thickness, ground tissue thickness, number of hairs, metaxylem vessel area, xylem vessel area, phloem tissue area, vascular bundle area, number of motor cells as well as number of opened stomata on both upper and lower epidermis. On the other hand, water stress increased (P< 0.05 the number of hairs and closed stomata on both upper and lower epidermis in flag leaves of the two wheat cultivars. The magnitude of decrease in all anatomical features in flag leaf was more pronounced with the sensitive cultivar. Furthermore, water stress led to a marked decrease (P< 0.05 in peduncle diameter, tracheids area, metaxylem vessel area, xylem tissue area, phloem tissue area, vascular tissue area, number of vascular bundles as well as opened stomata but increased the number of hairs and closed stomata on the peduncle surface of the two wheat cultivars. In relation to wheat cultivar, the sensitive was more affected by water stress than the resistant one. The application of GB, SA or their interaction induced some modifications in the anatomical features of the flag leaf and peduncle of main shoot which appeared to be

  4. Combining Medical Measurements from Diverse Sources: Experiences from Clinical Chemistry.

    Science.gov (United States)

    Bietenbeck, Andreas

    2016-01-01

    In health care, exchange of data is becoming increasingly important. However, it is still unclear how to interpret measurements of the same parameter from diverse data sources. In clinical chemistry point-of-care testing (POCT), e.g. for blood glucose, complements the analytical spectrum of central laboratories. Available data from "central laboratory", "professional POCT" and "non-professional" blood glucose measurements can be used to realistically simulate errors in different environments. The ability to classify the disease status or to detect a significant change based on these simulated measurements was assessed in several scenarios. Patients were simulated with realistic "true values" of blood glucose and a "diseased" or "non-diseased" status. To further simulate a change of blood glucose values, a random difference was created and classified as "significant" or "non-significant". Scientific literature was searched for accuracy and precision of blood glucose measurements in different environments. These values were used to calculate "measured values" from the "true values". In scenarios where only measurements from the same environment were combined the area under the ROC curve (AUC) was used to express classifier performance. Balanced accuracy was used for scenarios with a combination of measurements from different environments. Situations with and without prior knowledge of the data source were simulated separately. AUC for the classification of disease status remained around 0.68 in all scenarios. Median AUCs for the detection of a significant change ranged between 0.89 in the central laboratory and 0.76 in the non-professional environment. For the combination of different measurement environments median balanced accuracies reached 0.63 for the classification of the disease status and differed little between scenarios. Median balanced accuracy to detect a significant change ranged from 0.81 to 0.72. When there was no prior knowledge about the additional

  5. Diversity of endophytic fungi in Glycine max.

    Science.gov (United States)

    Fernandes, Elio Gomes; Pereira, Olinto Liparini; da Silva, Cynthia Cânedo; Bento, Claudia Braga Pereira; de Queiroz, Marisa Vieira

    2015-12-01

    Endophytic fungi are microorganisms that live within plant tissues without causing disease during part of their life cycle. With the isolation and identification of these fungi, new species are being discovered, and ecological relationships with their hosts have also been studied. In Glycine max, limited studies have investigated the isolation and distribution of endophytic fungi throughout leaves and roots. The distribution of these fungi in various plant organs differs in diversity and abundance, even when analyzed using molecular techniques that can evaluate fungal communities in different parts of the plants, such as denaturing gradient gel electrophoresis (DGGE). Our results show there is greater species richness of culturable endophytic filamentous fungi in the leaves G. max as compared to roots. Additionally, the leaves had high values for diversity indices, i.e. Simpsons, Shannon and Equitability. Conversely, dominance index was higher in roots as compared to leaves. The fungi Ampelomyces sp., Cladosporium cladosporioides, Colletotrichum gloeosporioides, Diaporthe helianthi, Guignardia mangiferae and Phoma sp. were more frequently isolated from the leaves, whereas the fungi Fusarium oxysporum, Fusarium solani and Fusarium sp. were prevalent in the roots. However, by evaluating the two communities by DGGE, we concluded that the species richness was higher in the roots than in the leaves. UPGMA analysis showed consistent clustering of isolates; however, the fungus Leptospora rubella, which belongs to the order Dothideales, was grouped among species of the order Pleosporales. The presence of endophytic Fusarium species in G. max roots is unsurprising, since Fusarium spp. isolates have been previously described as endophyte in other reports. However, it remains to be determined whether the G. max Fusarium endophytes are latent pathogens or non-pathogenic forms that benefit the plant. This study provides a broader knowledge of the distribution of the fungal

  6. The temperature effect on the glycine decomposition induced by 2 keV electron bombardment in space analog conditions

    Science.gov (United States)

    Pilling, Sergio; Nair, Binu G.; Escobar, Antonio; Fraser, Helen; Mason, Nigel

    2014-03-01

    Glycine is the simplest proteinaceous amino acid that has been extensively detected in carbonaceous meteorites and was recently observed in the cometary samples returned to Earth by NASA's Stardust spacecraft. In space, such species is exposed to several radiation fields at different temperatures. In aqueous solutions, this species appears mainly as zwitterionic glycine (+NH3CH2COO-) however, in solid phase, it may be found in amorphous or crystalline forms. Here, we present an experimental study on the destruction of two zwitterionic glycine crystals ( α- and β-form) at two different temperatures (300 K and 14 K) by 2 keV electrons in an attempt to test the behavior and stability of this molecular species in different space environments. The samples were analyzed in situ by Fourier transform infrared spectrometry at electron fluences. The experiments were carried out under ultra-high vacuum conditions at the Molecular Physics Laboratory at the Open University at Milton Keynes, UK. The dissociation cross section of glycine is approximately 5 times higher for the 14 K samples when compared to the 300 K samples. In contrast, no significant differences emerged between the dissociation cross sections of α- and β-forms of glycine for fixed temperature experiments. We therefore conclude that the destruction cross section is more heavily dependent on temperature than the phase of the condensed glycine material. This may be associated with the opening of additional reaction routes in the frozen samples involving the trapped daughter species (e.g. CO2 and CO). The half-life of studied samples extrapolated to space conditions shows that glycine molecules on the surface of interstellar grains has less survivability and they are highly sensitive to ambient radiations, however, they can survive extended period of time in the solar system like environments. Survivability increases by a factor of 5 if the samples are at 300 K when compared to low temperature experiments at 14

  7. Virtual and remote experiments for radiometric and photometric measurements

    Science.gov (United States)

    Thoms, L.-J.; Girwidz, R.

    2017-09-01

    The analysis of spectra is fundamental to our modern understanding of wave optics and colour perception. Since spectrometers are expensive, and accurate calibration is necessary to achieve high quality spectra, we developed a remote lab on optical spectrometry. With this tool, students can carry out real experiments over the Internet. In this article the pros and cons of remote labs, the physical background of optical spectrometry, and the development and use of a radiometric remote lab for higher education are discussed. The remote lab is freely accessible to everyone at http://virtualremotelab.net.

  8. Measures of agreement between computation and experiment: Validation metrics

    Science.gov (United States)

    Oberkampf, William L.; Barone, Matthew F.

    2006-09-01

    With the increasing role of computational modeling in engineering design, performance estimation, and safety assessment, improved methods are needed for comparing computational results and experimental measurements. Traditional methods of graphically comparing computational and experimental results, though valuable, are essentially qualitative. Computable measures are needed that can quantitatively compare computational and experimental results over a range of input, or control, variables to sharpen assessment of computational accuracy. This type of measure has been recently referred to as a validation metric. We discuss various features that we believe should be incorporated in a validation metric, as well as features that we believe should be excluded. We develop a new validation metric that is based on the statistical concept of confidence intervals. Using this fundamental concept, we construct two specific metrics: one that requires interpolation of experimental data and one that requires regression (curve fitting) of experimental data. We apply the metrics to three example problems: thermal decomposition of a polyurethane foam, a turbulent buoyant plume of helium, and compressibility effects on the growth rate of a turbulent free-shear layer. We discuss how the present metrics are easily interpretable for assessing computational model accuracy, as well as the impact of experimental measurement uncertainty on the accuracy assessment.

  9. Measurements of Form Factors with the BaBar Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Li, Selina Z.; /SLAC

    2011-08-25

    Selected recent results on measurements of form factors by the BaBar Collaboration are reviewed, including e{sup +}e{sup -} {yields} {eta}{prime}{gamma}, leptonic and semileptonic charm decays from data collected at or near the {Upsilon}(4S) resonance.

  10. Flow among Musicians: Measuring Peak Experiences of Student Performers

    Science.gov (United States)

    Sinnamon, Sarah; Moran, Aidan; O'Connell, Michael

    2012-01-01

    "Flow" is a highly coveted yet elusive state of mind that is characterized by complete absorption in the task at hand as well as by enhanced skilled performance. Unfortunately, because most measures of this construct have been developed in physical activity and sport settings, little is known about the applicability of flow scales to the…

  11. Valuing Informal Care Experience: Does Choice of Measure Matter?

    Science.gov (United States)

    Mentzakis, Emmanouil; McNamee, Paul; Ryan, Mandy; Sutton, Matthew

    2012-01-01

    Well-being equations are often estimated to generate monetary values for non-marketed activities. In such studies, utility is often approximated by either life satisfaction or General Health Questionnaire scores. We estimate and compare monetary valuations of informal care for the first time in the UK employing both measures, using longitudinal…

  12. Three Experiments Involving Probability Measurement Procedures with Mathematics Test Items.

    Science.gov (United States)

    Romberg, Thomas A.; And Others

    This is a report from the Project on Individually Guided Mathematics, Phase 2 Analysis of Mathematics Instruction. The report outlines some of the characteristics of probability measurement procedures for scoring objective tests, discusses hypothesized advantages and disadvantages of the methods, and reports the results of three experiments…

  13. Measures of agreement between computation and experiment:validation metrics.

    Energy Technology Data Exchange (ETDEWEB)

    Barone, Matthew Franklin; Oberkampf, William Louis

    2005-08-01

    With the increasing role of computational modeling in engineering design, performance estimation, and safety assessment, improved methods are needed for comparing computational results and experimental measurements. Traditional methods of graphically comparing computational and experimental results, though valuable, are essentially qualitative. Computable measures are needed that can quantitatively compare computational and experimental results over a range of input, or control, variables and sharpen assessment of computational accuracy. This type of measure has been recently referred to as a validation metric. We discuss various features that we believe should be incorporated in a validation metric and also features that should be excluded. We develop a new validation metric that is based on the statistical concept of confidence intervals. Using this fundamental concept, we construct two specific metrics: one that requires interpolation of experimental data and one that requires regression (curve fitting) of experimental data. We apply the metrics to three example problems: thermal decomposition of a polyurethane foam, a turbulent buoyant plume of helium, and compressibility effects on the growth rate of a turbulent free-shear layer. We discuss how the present metrics are easily interpretable for assessing computational model accuracy, as well as the impact of experimental measurement uncertainty on the accuracy assessment.

  14. SM Higgs Boson Measurements with the ATLAS Experiment

    CERN Document Server

    Veloce, Laurelle Maria; The ATLAS collaboration

    2017-01-01

    The data collected by ATLAS in 2015 and 2016 have been analyzed to study the properties of the Higgs boson. Improved measurements have been derived using several decay channels and dedicated categories sensitive to different production modes and kinematic properties of the Higgs boson.

  15. An Experiment in Radiation Measurement Using the Depron Instrument

    Science.gov (United States)

    Benghin, Victor V.; Nechaev, Oleg Y.; Zolotarev, Ivan A.; Amelyushkin, Alexander M.; Petrov, Vasiliy L.; Panasyuk, Milhail I.; Yashin, Ivan V.

    2018-02-01

    Most of the radiation measurements have been made onboard spacecraft flying along orbits with an inclination of up to 51.6 degrees. Due to the prospect of manned missions at orbits with larger inclinations, it is advisable to conduct preliminary detailed dosimetry measurements at a high-inclination orbit; due to its polar orbit, the Lomonosov satellite provides good opportunities for such study. We chose a method of cosmic radiation dosimetry based on semiconductor detectors. This method is widely used onboard spacecraft, including full-time radiation monitoring onboard the International Space Station (ISS). It should be noted that not only did the charged particles contribute significantly in the dose equivalent, but also did the neutrons. Semiconductor detectors have low sensitivity to neutron radiation and are not sufficient for detecting the expected flux of neutrons. We add a thermal neutron counter to the proposed device in order to provide an opportunity for estimation of neutron flux variations along the satellite trajectory. Thus, the design of the instrument DEPRON (Dosimeter of Electrons, PROtons and Neutrons) was determined. DEPRON is intended for registration of the absorbed doses and linear energy transfer spectra for high-energy electrons, protons and nuclei of space radiation, as well as registration of thermal neutrons. The present paper provides a brief description of the DEPRON instrument. Its calibration results and the first mission results of background radiation measurements are also presented.

  16. Experiences of mental illness stigma, prejudice and discrimination: a review of measures

    National Research Council Canada - National Science Library

    Brohan, Elaine; Slade, Mike; Clement, Sarah; Thornicroft, Graham

    2010-01-01

    .... This study aims to review current practice in the survey measurement of mental illness stigma, prejudice and discrimination experienced by people who have personal experience of mental illness...

  17. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.

    Science.gov (United States)

    Sekhar, Rajagopal V; Patel, Sanjeet G; Guthikonda, Anuradha P; Reid, Marvin; Balasubramanyam, Ashok; Taffet, George E; Jahoor, Farook

    2011-09-01

    Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood. We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress. Eight elderly and 8 younger subjects received stable-isotope infusions of [2H(2)]glycine, after which red blood cell (RBC) glutathione synthesis and concentrations, plasma oxidative stress, and markers of oxidant damage (eg, F(2)-isoprostanes) were measured. Elderly subjects were restudied after 2 wk of glutathione precursor supplementation. Compared with younger control subjects, elderly subjects had markedly lower RBC concentrations of glycine (486.7 ± 28.3 compared with 218.0 ± 23.7 μmol/L; P oxidative stress (304 ± 16 compared with 346 ± 20 Carratelli units; P oxidative stress and F(2)-isoprostanes. No differences in these measures were observed between younger subjects and supplemented elderly subjects. Glutathione deficiency in elderly humans occurs because of a marked reduction in synthesis. Dietary supplementation with the glutathione precursors cysteine and glycine fully restores glutathione synthesis and concentrations and lowers levels of oxidative stress and oxidant damages. These findings suggest a practical and effective approach to decreasing oxidative stress in aging.

  18. Measuring microbial fitness in a field reciprocal transplant experiment.

    Science.gov (United States)

    Boynton, Primrose J; Stelkens, Rike; Kowallik, Vienna; Greig, Duncan

    2017-05-01

    Microbial fitness is easy to measure in the laboratory, but difficult to measure in the field. Laboratory fitness assays make use of controlled conditions and genetically modified organisms, neither of which are available in the field. Among other applications, fitness assays can help researchers detect adaptation to different habitats or locations. We designed a competitive fitness assay to detect adaptation of Saccharomyces paradoxus isolates to the habitat they were isolated from (oak or larch leaf litter). The assay accurately measures relative fitness by tracking genotype frequency changes in the field using digital droplet PCR (DDPCR). We expected locally adapted S. paradoxus strains to increase in frequency over time when growing on the leaf litter type from which they were isolated. The DDPCR assay successfully detected fitness differences among S. paradoxus strains, but did not find a tendency for strains to be adapted to the habitat they were isolated from. Instead, we found that the natural alleles of the hexose transport gene we used to distinguish S. paradoxus strains had significant effects on fitness. The origin of a strain also affected its fitness: strains isolated from oak litter were generally fitter than strains from larch litter. Our results suggest that dispersal limitation and genetic drift shape S. paradoxus populations in the forest more than local selection does, although further research is needed to confirm this. Tracking genotype frequency changes using DDPCR is a practical and accurate microbial fitness assay for natural environments. © 2016 The Authors. Molecular Ecology Resources Published by John Wiley & Sons Ltd.

  19. Measurement of the top quark charge in the ATLAS experiment

    CERN Document Server

    Federic, P

    2012-01-01

    A measurement of the top quark charge using the lepton+jets final state resulting from ttbar pair production is presented, using data from the ATLAS detector. The results were obtained using proton-proton collision data at a center-of-mass of 7 TeV corresponding to an integrated luminosity of 0.70 fb-1 . The hypothesis that the top quark is instead an exotic quark with charge -4/3e is excluded at more than five standard deviations.

  20. Dijets in diffractive photoproduction measured with the ZEUS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Renner, R.

    2006-10-15

    The diffractive photoproduction of dijets in electron-proton scattering has been studied using 77.1 pb{sup -1} of data taken with the ZEUS detector at HERA. The measurements have been made at a centre-of- mass energy {radical}s=318 GeV in the kinematic range 0.27.5 and 6.5 GeV, respectively, and to be in the pseudorapidity range -1.5<{eta}<1.5. Differential cross sections have been measured and been confronted with the predictions from leading order Monte Carlo simulations and next-to-leading order QCD calculations. (orig.)

  1. Design and interpretation of experiments to measure the effective removal section.

    CERN Document Server

    Desdin, L

    2001-01-01

    Paper is devoted to develop a single analytical instrument to design and interpret experiment to measure the neutron removal cross sections. There were analyzed the influence of the geometrical and nuclear parameters into the neutron removal cross sections values measured

  2. Ultrasonic measurement of the elastic properties of benzoyl glycine ...

    Indian Academy of Sciences (India)

    [16] H J McSkimin, in Physical acoustics edited by W P Mason (Academic Press, New. York, 1964) vol. I. Pt. A. [17] J F Nye, Physical properties of crystals (Oxford University Press, London, 1957). [18] B A Auld, Acoustic fields and waves in solids (John Wiley and Sons, NY, 1973) vol. 1. 94. Pramana - J. Phys., Vol. 62, No.

  3. Idaho field experiment 1981. Volume 2: measurement data

    Energy Technology Data Exchange (ETDEWEB)

    Start, G E; Sagendorf, J F; Ackermann, G R; Cate, J H; Hukari, N F; Dickson, C R

    1984-04-01

    The 1981 Idaho Field Experiment was conducted in southeastern Idaho over the upper Snake River Plain. Nine test-day case studies were conducted between July 15 and 30, 1981. Releases of SF/sub 6/ gaseous tracer were made for 8-hour periods from 46m above ground. Tracer was sampled hourly, for 12 sequential hours, at about 100 locations within an area 24km square. Also, a single total integrated sample of about 30 hours duration was collected at approximately 100 sites within an area 48 by 72km square (using 6km spacings). Extensive tower profiles of meteorology at the release point were collected. RAWINSONDES, RABALS and PIBALS were collected at 3 to 5 sites. Horizontal, low-altitude winds were monitored using the INEL MESONET. SF/sub 6/ tracer plume releases were marked with co-located oil fog releases and bi-hourly sequential launches of tetroon pairs. Aerial LIDAR observations of the oil fog plume and airborne samples of SF/sub 6/ were collected. High altitude aerial photographs of daytime plumes were collected. Volume II lists the data in tabular form or cites the special supplemental reports by other participating contractors. While the primary user file and the data archive are maintained on 9 track/1600 cpi magnetic tapes, listings of the individual values are provided for the user who either cannot utilize the tapes or wishes to preview the data. The accuracies and quality of these data are described.

  4. Comparison of Small RNA Profiles of Glycine max and Glycine soja at Early Developmental Stages.

    Science.gov (United States)

    Sun, Yuzhe; Mui, Zeta; Liu, Xuan; Yim, Aldrin Kay-Yuen; Qin, Hao; Wong, Fuk-Ling; Chan, Ting-Fung; Yiu, Siu-Ming; Lam, Hon-Ming; Lim, Boon Leong

    2016-12-06

    Small RNAs, including microRNAs (miRNAs) and phased small interfering RNAs (phasiRNAs; from PHAS loci), play key roles in plant development. Cultivated soybean, Glycine max, contributes a great deal to food production, but, compared to its wild kin, Glycine soja, it may lose some genetic information during domestication. In this work, we analyzed the sRNA profiles of different tissues in both cultivated (C08) and wild soybeans (W05) at three stages of development. A total of 443 known miRNAs and 15 novel miRNAs showed varying abundances between different samples, but the miRNA profiles were generally similar in both accessions. Based on a sliding window analysis workflow that we developed, 50 PHAS loci generating 55 21-nucleotide phasiRNAs were identified in C08, and 46 phasiRNAs from 41 PHAS loci were identified in W05. In germinated seedlings, phasiRNAs were more abundant in C08 than in W05. Disease resistant TIR-NB-LRR genes constitute a very large family of PHAS loci. PhasiRNAs were also generated from several loci that encode for NAC transcription factors, Dicer-like 2 (DCL2), Pentatricopeptide Repeat (PPR), and Auxin Signaling F-box 3 (AFB3) proteins. To investigate the possible involvement of miRNAs in initiating the PHAS-phasiRNA pathway, miRNA target predictions were performed and 17 C08 miRNAs and 15 W05 miRNAs were predicted to trigger phasiRNAs biogenesis. In summary, we provide a comprehensive description of the sRNA profiles of wild versus cultivated soybeans, and discuss the possible roles of sRNAs during soybean germination.

  5. Experiment of electrical conductivity at low temperature (preliminary measurement)

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Y.; Wang, H.

    1998-07-01

    A muon collider needs very large amount of RF power, how to reduce the RF power consumption is of major concern. Thus the application of liquid nitrogen cooling has been proposed. However, it is known that the electrical conductivity depends on many factors and the data from different sources vary in a wide range, especially the data of conductivity of beryllium has no demonstration in a real application. Therefore it is important to know the conductivity of materials, which are commercially available, and at a specified frequency. Here, the results of the preliminary measurement on the electrical conductivity of copper at liquid nitrogen temperature are summarized. Addressed also are the data fitting method and the linear expansion of copper.

  6. Luminosity measurements for the R scan experiment at BESIII

    Science.gov (United States)

    Ablikim, M.; Achasov, M. N.; Ahmed, S.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; De Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, Lei; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Y. B.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J.; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Y. Y.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Z. Y.; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. N.; Zhang, Y. T.; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; BESIII Collaboration

    2017-06-01

    By analyzing the large-angle Bhabha scattering events e+e- → (γ)e+e- and diphoton events e+e- → (γ)γγ for the data sets collected at center-of-mass (c.m.) energies between 2.2324 and 4.5900 GeV (131 energy points in total) with the upgraded Beijing Spectrometer (BESIII) at the Beijing Electron-Positron Collider (BEPCII), the integrated luminosities have been measured at the different c.m. energies, individually. The results are important inputs for the R value and J/ψ resonance parameter measurements. Supported by National Key Basic Research Program of China (2015CB856700), National Natural Science Foundation of China (NSFC) (10935007, 11121092, 11125525, 11235011, 11322544, 11335008, 11375170, 11275189, 11079030, 11475164, 11475169, 11005109, 10979095, 11275211), Chinese Academy of Sciences (CAS) Large-Scale Scientific Facility Program; Joint Large-Scale Scientific Facility Funds of the NSFC and CAS (11179007, U1232201, U1332201, U1532102). (KJCX2-YW-N29, KJCX2-YW-N45). 100 Talents Program of CAS, INPAC and Shanghai Key Laboratory for Particle Physics and Cosmology, German Research Foundation DFG (Collaborative Research Center CRC-1044), Istituto Nazionale di Fisica Nucleare, Italy, Ministry of Development of Turkey (DPT2006K-120470), Russian Foundation for Basic Research (14-07-91152), U. S. Department of Energy (DE-FG02-04ER41291, DE-FG02-05ER41374, DE-FG02-94ER40823, DESC0010118), U.S. National Science Foundation, University of Groningen (RuG) and the Helmholtzzentrum fuer Schwerionenforschung GmbH (GSI), Darmstadt, WCU Program of National Research Foundation of Korea (R32-2008-000-10155-0)

  7. Glycine-nitrate combustion synthesis of oxide ceramic powders

    Energy Technology Data Exchange (ETDEWEB)

    Chick, L.A.; Pederson, L.R.; Maupin, G.D.; Bates, J.L.; Thomas, L.E.; Exarhos, G.J. (Pacific Northwest Lab., Richland, WA (United States))

    1990-09-01

    A new combustion synthesis method, the glycine-nitrate process, has been used to prepare oxide ceramic powders, including substituted chromite and manganite powders of high quality. A precursor was prepared by combining glycine with metal nitrates in their appropriate stoichiometric ratios in an aqueous solution. The precursor was heated to evaporate excess water, yielding a viscous liquid. Further heating to about 180[degrees]C caused the precursor liquid to autoignite. Combustion was rapid and self-sustaining, with flame temperatures ranging from 1100 to 1450[degrees]C. The chromite product was compositionally homogeneous with a specific surface area of 32 m[sup 2]/g, while the manganite product was composed of two distinct phases with a 23 m[sup 2]/g surface area after calcination. When compared to similar compositions made using the amorphous citrate process, glycine-nitrate-produced powders had greater compositional uniformity, lower residual carbon levels and smaller particle sizes.

  8. An Analysis of the NEXAFS Spectra of a molecular crystal: alpha-Glycine

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, Craig P.; Saykally, Richard J.; Prendergast, David

    2010-06-18

    The nitrogen K-edge Near Edge X-ray Absorption Fine Structure (NEXAFS) spectrum of alpha-crystalline glycine has been calculated for temperatures ranging from 0 K to 450 K. Significant temperature dependent spectral changes are predicted. The calculated room temperature spectrum is in good agreement with experiment. At high temperatures, molecular motions strongly influence the spectrum, as any unique spectrum from an individual instantaneous configuration does not resemble the experimental result or the average calculated spectrum; complex coupled motions in this prototypical molecular crystal underlie the observed spectral changes.

  9. Luminosity measurements with the LUCID detector in the ATLAS experiment

    CERN Document Server

    Valentinetti, Sara

    La misura della luminosità è un obiettivo importante per tutta la fisica del modello standard e per la scoperta di nuova fisica, poiché è legata alla sezione d'urto (σ) e al rate di produzione (R) di un determinato processo dalla relazione L = R*σ. Nell'eserimento ATLAS a LHC è installato un monitor di luminosità dedicato chiamato LUCID (Luminosity measurements Using Cherenkov Integrating Detector). Grazie ai dati acquisiti durante il 2010 la valutazione off-line delle performances del LUCID e l'implementazione di controlli on-line sulla qualità dei dati raccolti è stata possibile. I dati reali sono stati confrontati con i dati Monte Carlo e le simulazioni sono state opportunamente aggiustate per ottimizzare l'accordo tra i due. La calibrazione della luminosità relativa che permette di ottenere una valutazione della luminosità assoluta è stata possibile grazie ai cosiddetti Van der Meer scan, grazie ai quale è stata ottenuta una precisione dell'11%. L'analisi della fisica del decadimento della Z...

  10. Hybridization between GM soybean (Glycine max (L.) Merr.) and wild soybean (Glycine soja Sieb. et Zucc.) under field conditions in Japan.

    Science.gov (United States)

    Mizuguti, Aki; Ohigashi, Kentaro; Yoshimura, Yasuyuki; Kaga, Akito; Kuroda, Yosuke; Matsuo, Kazuhito

    2010-01-01

    Accumulation of information about natural hybridization between GM soybean (Glycine max) and wild soybean (Glycine soja) is required for risk assessment evaluation and to establish biosafety regulations in Japan. This is particularly important in areas where wild relatives of cultivated soybean are grown (i.e. East Asia including Japan). To collect information on temporal and spatial factors affecting variation in hybridization between wild and GM soybean, a two year hybridization experiment was established that included one wild soybean and five GM soybean cultivars with different maturity dates. Hybridization frequencies ranged from 0 to 0.097%. The maximum hybridization frequency (0.097%) was obtained from wild soybean crossed with GM soybean cv. AG6702RR, which were adjacently cultivated with wild soybean, with 25 hybrids out of 25 741 seedlings tested. Cultivar AG6702RR had the most synchronous flowering period with wild soybean. Ten hybrids out of 25 741 were produced by crossing with cv. AG5905RR, which had the second most synchronous flowering period with wild soybean. Most hybrids were found where GM and wild soybeans were adjacently cultivated, whereas only one hybrid was detected from wild soybean plants at 2 m, 4 m and 6 m from a pollen source (GM soybean). Differences in flowering phenology, isolation distance and presence of buffer plants accounted for half of the variation in hybridization frequency in this study. Temporal and spatial isolation will be effective strategies to minimize hybridization between GM and wild soybean. © ISBR, EDP Sciences.

  11. A Simple Experiment To Measure the Content of Oxygen in the Air Using Heated Steel Wool

    Science.gov (United States)

    Vera, Francisco; Rivera, Rodrigo; Nunez, Cesar

    2011-01-01

    The typical experiment to measure the oxygen content in the atmosphere uses the rusting of steel wool inside a closed volume of air. Two key aspects of this experiment that make possible a successful measurement of the content of oxygen in the air are the use of a closed atmosphere and the use of a chemical reaction that involves the oxidation of…

  12. The transcriptomic changes of Huipizhi Heidou (Glycine max), a nematode-resistant black soybean during Heterodera glycines race 3 infection.

    Science.gov (United States)

    Li, Shuang; Chen, Yu; Zhu, Xiaofeng; Wang, Yuanyuan; Jung, Ki-Hong; Chen, Lijie; Xuan, Yuanhu; Duan, Yuxi

    2017-11-14

    Glycine max (soybean) is an extremely important crop, representing a major source of oil and protein for human beings. Heterodera glycines (soybean cyst nematode, SCN) infection severely reduces soybean production; therefore, protecting soybean from SCN has become an issue for breeders. Black soybean has exhibited a different grade of resistance to SCN. However, the underlying mechanism of Huipizhi Heidou resistance against SCN remains elusive. The Huipizhi Heidou (ZDD2315) and race 3 of Heterodera glycines were chosen to study the mechanism of resistance via examination of transcriptomic changes. After 5, 10, and 15days of SCN infection, whole roots were sampled for RNA extraction, and uninfected samples were simultaneously collected as a control. 740, 1413, and 4925 genes were isolated by padj (p-value adjusted)soybean and cyst-nematode interaction. Copyright © 2017 Elsevier GmbH. All rights reserved.

  13. Effect of fungicides and bioagents on number of microorganisms in soil and yield of soybean (Glycine max

    Directory of Open Access Journals (Sweden)

    GAURAV MISHRA

    2014-07-01

    Full Text Available Mishra G, Kumar N, Giri K, Pandey S, Kumar R. 2014. Effect of fungicides and bioagents on number of microorganisms in soil and yield of soybean (Glycine max. Nusantara Bioscience 6: 45-48. In field experiments, the effect of selected fungicides and bioagents on number of soil microorganisms and yield of soybean (Glycine max L. Merill was investigated. The results showed that some of the crop protections preparations applied in the experiment (as seed dressing increased the populations of the examined microorganisms after the harvest of crops. Maximum counts of bacteria were recorded with Thiomethaxam at 3 g kg-1 while Pseudomonas at 3 g kg-1 showed the highest population of fungi, Actinomycetes, B. japonicum, PSB and Pseudomonas. The highest straw and grain yields of 3241.6 and 1439.4 kg ha-1, respectively, were recorded with Pseudomonas at 3 g kg-1.

  14. Measuring participation: the Patient-Reported Outcomes Measurement Information System experience.

    Science.gov (United States)

    Bode, Rita K; Hahn, Elizabeth A; DeVellis, Robert; Cella, David

    2010-09-01

    To describe the lessons learned in the initial development of Patient-Reported Outcomes Measurement Information System social function item banks. Development and testing of 2 item pools within a general population to create item banks that measure ability to participate and satisfaction with participation in social activities. Administration via the Internet. General population members (N=956) of a national polling organization registry participated; data for 768 and 778 participants were used in the analysis. Not applicable. Measures of ability to participate and satisfaction with participation in social activities. Fifty-six items measuring the ability to participate were essentially unidimensional but did not fit an item response theory model. As a result, item banks were not developed for these items. Of the 56 items measuring satisfaction with participation, 14 items measuring social roles and 12 items measuring discretionary activities were unidimensional and met item response theory model assumptions. Two 7-item short forms were also developed. Four lessons, mostly concerning item content, were learned in the development of banks measuring social function. These lessons led to item revisions that are being tested in subsequent studies. Copyright 2010 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  15. 77 FR 21532 - Glycine From the People's Republic of China: Preliminary Partial Affirmative Determination of...

    Science.gov (United States)

    2012-04-10

    ... glycine to U.S. Pharmaceutical (USP) grade glycine in India did not substantially transform the glycine in... to be discussed. At the hearing, each party may make an affirmative presentation only on issues raised in that party's case brief and may make rebuttal presentations only on arguments included in that...

  16. Biocompatibility of poly(DL-lactic acid/glycine) copolymers

    NARCIS (Netherlands)

    Schakenraad, J.M.; Dijkstra, Pieter J.

    1991-01-01

    In this review the authors discuss the polymer chemical, physical and cell biological aspects of poly (DL-lactic acid/glycine) copolymers, both in vitro and in vivo. The mechanism and rate of degradation and the degree of foreign body reaction were evaluated as a function of the molecular

  17. Evaluation of iron transport from ferrous glycinate liposomes using ...

    African Journals Online (AJOL)

    Background: Iron fortification of foods is currently a strategy employed to fight iron deficiency in countries. Liposomes were assumed to be a potential carrier of iron supplements. Objective: The objective of this study was to investigate the iron transport from ferrous glycinate liposomes, and to estimate the effects of liposomal ...

  18. A critical role for glycine transporters in hyperexcitability disorders

    Directory of Open Access Journals (Sweden)

    Robert J Harvey

    2008-03-01

    Full Text Available Defects in mammalian glycinergic neurotransmission result in a complex motor disorder characterized by neonatal hypertonia and an exaggerated startle refl ex, known as hyperekplexia (OMIM 149400. This affects newborn children and is characterized by noise or touch-induced seizures that result in muscle stiffness and breath-holding episodes. Although rare, this disorder can have serious consequences, including brain damage and/or sudden infant death. The primary cause of hyperekplexia is missense and nonsense mutations in the glycine receptor (GlyR α1 subunit gene (GLRA1 on chromosome 5q33.1, although we have also discovered rare mutations in the genes encoding the GlyR β subunit (GLRB and the GlyR clustering proteins gephyrin (GPNH and collybistin (ARHGEF9. Recent studies of the Na+ /Cl--dependent glycine transporters GlyT1 and GlyT2 using mouse knockout models and human genetics have revealed that mutations in GlyT2 are a second major cause of hyperekplexia, while the phenotype of the GlyT1 knockout mouse resembles a devastating neurological disorder known as glycine encephalopathy (OMIM 605899. These findings highlight the importance of these transporters in regulating the levels of synaptic glycine.

  19. 21 CFR 520.550 - Dextrose/glycine/electrolyte.

    Science.gov (United States)

    2010-04-01

    ... therapy. Oral therapy in these cases is too slow. Animals which cannot drink after initial intravenous...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.550 Dextrose/glycine... treatment following intravenous fluid therapy. (2) Dissolve each packet in two quarts of warm water and...

  20. Screening Soybean (Glycine max (L) Merril) lines for morphological ...

    African Journals Online (AJOL)

    23 Screening Soybean (Glycine mtLr: (L) Merril) lines for morphological resistance to the southern green stink bug,. Nezara viridu!a (L) (Hemiptera: Pentatomidae). Table 1. Summary of the A NOVA table for the selected soybean morphological characteristics. (a) Season1 {97a). Plant. Abaxial height trichome density.

  1. Evaluation of iron transport from ferrous glycinate liposomes using ...

    African Journals Online (AJOL)

    2017-09-03

    Sep 3, 2017 ... Abstract. Background: Iron fortification of foods is currently a strategy employed to fight iron deficiency in countries. Liposomes were assumed to be a potential carrier of iron supplements. Objective: The objective of this study was to investigate the iron transport from ferrous glycinate liposomes, and to ...

  2. Glycine max and Moringa oleifera : nutritional values, processing ...

    African Journals Online (AJOL)

    Soymilk, one of the end-products of Glycine max (soy), is a highly nutritious drink containing a high quality protein which can greatly contribute to strengthen some human body functions. Regarding M. oleifera, it's called “miracle plant” because of the usefulness of all its parts in nutrition, medicine and cosmetic. Therefore ...

  3. Characterization and sequence analysis of cysteine and glycine-rich ...

    African Journals Online (AJOL)

    Cysteine and glycine rich protein, CSRP3 also referred to as the muscle LIM protein (MLP), has been investigated in native Egyptian cattle and buffalo (river buffalo). RNA extraction and cDNA synthesis were conducted from different tissue samples. Primers specific for CSRP3 were designed using known cDNA sequences ...

  4. Classical dynamics simulations of interstellar glycine formation via ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 129; Issue 10. Classical dynamics simulations of interstellar glycine formation via CH₂ = NH + CO + H₂O reaction. YOGESHWARAN KRISHNAN ALLEN VINCENT MANIKANDAN PARANJOTHY. REGULAR ARTICLE Volume 129 Issue 10 October 2017 pp 1571- ...

  5. Soybean ( Glycine max ) as a versatile biocatalyst for organic ...

    African Journals Online (AJOL)

    Soybean ( Glycine max ) as a versatile biocatalyst for organic synthesis. ... Most of the obtained alcohols have commercial value as cosmetic fragrances. Although, the enzymes present in soybean (reductase/lipase) has not been defined, the reaction is an important route for the preparation of pure alcohols and carboxylic ...

  6. Soybean performance ( Glycine max (L) Merr ) on tropical soils with ...

    African Journals Online (AJOL)

    Soybean performance ( Glycine max (L) Merr ) on tropical soils with nitrogen and phosphorus fertilization. ... Abstract. Pot trial was conducted to investigate the effects of soil types, nitrogen and phosphorus application on the yield, and nodulation and nutrient uptake of soybean grown on tropical soils. Results showed that ...

  7. A critical role for glycine transporters in hyperexcitability disorders.

    Science.gov (United States)

    Harvey, Robert J; Carta, Eloisa; Pearce, Brian R; Chung, Seo-Kyung; Supplisson, Stéphane; Rees, Mark I; Harvey, Kirsten

    2008-01-01

    Defects in mammalian glycinergic neurotransmission result in a complex motor disorder characterized by neonatal hypertonia and an exaggerated startle reflex, known as hyperekplexia (OMIM 149400). This affects newborn children and is characterized by noise or touch-induced seizures that result in muscle stiffness and breath-holding episodes. Although rare, this disorder can have serious consequences, including brain damage and/or sudden infant death. The primary cause of hyperekplexia is missense and non-sense mutations in the glycine receptor (GlyR) alpha1 subunit gene (GLRA1) on chromosome 5q33.1, although we have also discovered rare mutations in the genes encoding the GlyR beta subunit (GLRB) and the GlyR clustering proteins gephyrin (GPNH) and collybistin (ARHGEF9). Recent studies of the Na(+)/Cl(-)-dependent glycine transporters GlyT1 and GlyT2 using mouse knockout models and human genetics have revealed that mutations in GlyT2 are a second major cause of hyperekplexia, while the phenotype of the GlyT1 knockout mouse resembles a devastating neurological disorder known as glycine encephalopathy (OMIM 605899). These findings highlight the importance of these transporters in regulating the levels of synaptic glycine.

  8. Characterization of potassium glycinate for carbon dioxide absorption purposes

    NARCIS (Netherlands)

    Portugal, A. F.; Derks, P. W. J.; Versteeg, G. F.; Magalhaes, F. D.; Mendes, A.

    2007-01-01

    Aqueous solutions of potassium glycinate were characterized for carbon dioxide absorption purposes. Density and viscosity of these solutions, with concentrations ranging from 0.1 to 3 M, were determined at temperatures from 293 to 313 K. Diffusivity of CO2 in solution was estimated applying the

  9. Protective effect of phenylalanine and glycine on chloramphenicol ...

    African Journals Online (AJOL)

    The effect of phenylalanine and glycine on chloramphenicol (CAP) induced bone marrow toxicity in albino rats infected with Klebsiella pneumoniae was investigated. The aim was investigate whether the treatment of the infected rats with either of these amino acids or their combination could reverse the major bone marrow ...

  10. Characterization and sequence analysis of cysteine and glycine-rich ...

    African Journals Online (AJOL)

    Tarek

    2011-04-18

    Apr 18, 2011 ... Cysteine and glycine rich protein, CSRP3 also referred to as the muscle LIM protein (MLP), has been investigated in native Egyptian cattle and buffalo (river buffalo). RNA extraction and cDNA synthesis were conducted from different tissue samples. Primers specific for CSRP3 were designed using known.

  11. Synthetic and mechanistic insight into nosylation of glycine residues

    DEFF Research Database (Denmark)

    Stuhr-Hansen, Nicolai; Sølling, Theis Ivan; Strømgaard, Kristian

    2013-01-01

    The Fukuyama-Mitsunobu alkylation procedure is widely used to introduce alkyl substituents to amino groups in general and N-alkylation of peptides in particular. Here we have investigated the procedure in detail for N-alkylation of peptides with N-terminal glycine residues, based on the observati...... the N(-) residue can become closer to the SO(2) unit. Finally, the mono-nosylated N-terminal glycine could be obtained by careful optimization of the procedure, adding only one equivalent of 2-nitrobenzenesulfonyl chloride.......The Fukuyama-Mitsunobu alkylation procedure is widely used to introduce alkyl substituents to amino groups in general and N-alkylation of peptides in particular. Here we have investigated the procedure in detail for N-alkylation of peptides with N-terminal glycine residues, based on the observation...... that standard conditions lead to substantial bis-nosylation of the glycine amino group. A systematic evaluation of this observation was carried out and it was demonstrated that for peptides with alanine, β-alanine or γ-aminobutyric acid (GABA) as N-terminal residues mono-nosylation was observed under the same...

  12. Efficient production of transgenic soybean (Glycine max [L] Merrill ...

    African Journals Online (AJOL)

    The present study was designed to evaluate the transformation efficiency and proof the capability of whisker supersonic (WSS) method as an alternative option for soybean (Glycine max [L] Merrill) transformation. We compared soybean transformation efficiency obtained by WSS-mediated with that of particle bombardment ...

  13. Patient experience and satisfaction with inpatient service: development of short form survey instrument measuring the core aspect of inpatient experience.

    Directory of Open Access Journals (Sweden)

    Eliza L Y Wong

    Full Text Available Patient experience reflects quality of care from the patients' perspective; therefore, patients' experiences are important data in the evaluation of the quality of health services. The development of an abbreviated, reliable and valid instrument for measuring inpatients' experience would reflect the key aspect of inpatient care from patients' perspective as well as facilitate quality improvement by cultivating patient engagement and allow the trends in patient satisfaction and experience to be measured regularly. The study developed a short-form inpatient instrument and tested its ability to capture a core set of inpatients' experiences. The Hong Kong Inpatient Experience Questionnaire (HKIEQ was established in 2010; it is an adaptation of the General Inpatient Questionnaire of the Care Quality Commission created by the Picker Institute in United Kingdom. This study used a consensus conference and a cross-sectional validation survey to create and validate a short-form of the Hong Kong Inpatient Experience Questionnaire (SF-HKIEQ. The short-form, the SF-HKIEQ, consisted of 18 items derived from the HKIEQ. The 18 items mainly covered relational aspects of care under four dimensions of the patient's journey: hospital staff, patient care and treatment, information on leaving the hospital, and overall impression. The SF-HKIEQ had a high degree of face validity, construct validity and internal reliability. The validated SF-HKIEQ reflects the relevant core aspects of inpatients' experience in a hospital setting. It provides a quick reference tool for quality improvement purposes and a platform that allows both healthcare staff and patients to monitor the quality of hospital care over time.

  14. Low-temperature phase transition in γ-glycine single crystal. Pyroelectric, piezoelectric, dielectric and elastic properties

    Energy Technology Data Exchange (ETDEWEB)

    Tylczyński, Zbigniew, E-mail: zbigtyl@amu.edu.pl [Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań (Poland); Busz, Piotr [Institute of Molecular Physics, Polish Academy of Science, Smoluchowskiego 17, 60-179 Poznań (Poland)

    2016-11-01

    Temperature changes in the pyroelectric, piezoelectric, elastic and dielectric properties of γ-glycine crystals were studied in the range 100 ÷ 385 K. The pyroelectric coefficient increases monotonically in this temperature range and its value at RT was compared with that of other crystals having glycine molecules. A big maximum in the d14 component of piezoelectric tensor compared by maximum in attenuation of the resonant face-shear mode were observed at 189 K. The components of the elastic stiffness tensor and other components of the piezoelectric tensor show anomalies at this temperature. The components of electromechanical coupling coefficient determined indicate that γ-glycine is a weak piezoelectric. The real and imaginary part of the dielectric constant measured in the direction perpendicular to the trigonal axis show the relaxation anomalies much before 198 K and the activation energies were calculated. These anomalies were interpreted as a result of changes in the NH{sub 3}{sup +} vibrations through electron-phonon coupling of the so called “dynamical transition”. The anomalies of dielectric constant ε*{sub 11} and piezoelectric tensor component d{sub 14} taking place at 335 K are associated with an increase in ac conductivity caused by charge transfer of protons. - Graphical abstract: Imaginary part of dielectric constant in [100] direction. - Highlights: • Piezoelectric, elastic and dielectric constants anomalies were discovered at 189 K. • These anomalies were interpreted as a result of so called “dynamical transition”. • Relaxational dielectric anomaly was explained by the dynamics of glycine molecules. • Pyroelectric coefficient of γ-glycine was determined in a wide temperature range. • Complex dielectric & piezoelectric anomalies at 335 K were caused by protons hopping.

  15. Survival in seawater of Escherichia coli cells grown in marine sediments containing glycine betaine.

    OpenAIRE

    Gauthier, M J; Le Rudulier, D

    1990-01-01

    Considering both the protective effect of glycine betaine (GB) on enteric bacteria grown at high osmolarity and the possible presence of GB in marine sediments, we have analyzed the survival, in nutrient-free seawater, of Escherichia coli cells incubated in sediments supplemented with GB or not supplemented and measured the efficiency of GB uptake systems and the expression of proP and proU genes in both seawater and sediments. We did this by using strains harboring proP-lacZ and proU-lacZ op...

  16. The List Experiment for Measuring Abortion: What We Know and What We Need.

    Science.gov (United States)

    Moseson, Heidi; Treleaven, Emily; Gerdts, Caitlin; Diamond-Smith, Nadia

    2017-11-17

    Measuring abortion incidence and prevalence is often difficult because of under-reporting and other biases, complicated research designs, and other issues. Recently, family planning researchers have introduced a new method called the list experiment, adopted from political science and economics, to measure abortion. Three completed studies and at least four studies currently underway use this method to measure abortion in several countries. We discuss the lessons learned from completed studies, when the list experiment may and may not be appropriate, and open questions regarding the use of the list experiment for abortion research. This method has the potential to improve measures of abortion prevalence and incidence, which could translate to better-informed interventions to increase abortion access and reduce unmet need for family planning. Future research should further clarify the advantages and limitations of the list experiment for measuring abortion. © 2017 The Population Council, Inc.

  17. Genetic architecture of wild soybean (Glycine soja) response to soybean cyst nematode (Heterodera glycines).

    Science.gov (United States)

    Zhang, Hengyou; Song, Qijian; Griffin, Joshua D; Song, Bao-Hua

    2017-12-01

    The soybean cyst nematode (SCN) is one of the most destructive pathogens of soybean plants worldwide. Host-plant resistance is an environmentally friendly method to mitigate SCN damage. To date, the resistant soybean cultivars harbor limited genetic variation, and some are losing resistance. Thus, a better understanding of the genetic mechanisms of the SCN resistance, as well as developing diverse resistant soybean cultivars, is urgently needed. In this study, a genome-wide association study (GWAS) was conducted using 1032 wild soybean (Glycine soja) accessions with over 42,000 single-nucleotide polymorphisms (SNPs) to understand the genetic architecture of G. soja resistance to SCN race 1. Ten SNPs were significantly associated with the response to race 1. Three SNPs on chromosome 18 were localized within the previously identified quantitative trait loci (QTLs), and two of which were localized within a strong linkage disequilibrium block encompassing a nucleotide-binding (NB)-ARC disease resistance gene (Glyma.18G102600). Genes encoding methyltransferases, the calcium-dependent signaling protein, the leucine-rich repeat kinase family protein, and the NB-ARC disease resistance protein, were identified as promising candidate genes. The identified SNPs and candidate genes can not only shed light on the molecular mechanisms underlying SCN resistance, but also can facilitate soybean improvement employing wild genetic resources.

  18. Application of Glycine, Tufool and Salicylic Acid in Sugar beet (Beta vulgaris L. under Drought Conditions

    Directory of Open Access Journals (Sweden)

    Mohammad Kheirkhah

    2016-03-01

    Full Text Available Sugar beet is one of strategic products to supply sugar in water limited areas of Iran. Thus, proper managements to supply enouph water in production of sugar beet is very important. To evaluate the effects of some anti stress substances like salicylic acid, tyuful and glycine to irritigate the effect of early water deficit on suger beet, an experiment based on randomized complete block design with three replications was carried out at the Research Farm of Fariman Sugar Factory in 2013. Treatments consisted of control (without using anti stress substances, with three concentration of salicylic acid (0.1, 0.5, and 1 mM, tyuful with three concentration (0.5, 1 and 1.5 liter per thousand and glycine with three concentration (1, 2 and 3 liters per thousand. The results showed that the effects of anti-stress materials significantly affected the sugar content, root yield, white sugar yield and harmful nitrogen. Highest sugar content (15.65%, root yield (83.82 t.ha-1 and white sugar percentage (11.15% were obtained by using tyuful 1.5 lit/1000. While, the lowest levels of these characters were obtained from control (not using anti stress substances. Maximum harmful nitrogen was produced in control treatment (4.38 and highest level of alkalinity with mean of 3.49 was observed by using 3 lit/1000 of glycine. Our results showed that all of the anti stress substances had positive effects on sugar beet under drought stress condition.

  19. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics.

    Science.gov (United States)

    Ji, Y; Hebbring, S; Zhu, H; Jenkins, G D; Biernacka, J; Snyder, K; Drews, M; Fiehn, O; Zeng, Z; Schaid, D; Mrazek, D A; Kaddurah-Daouk, R; Weinshilboum, R M

    2011-01-01

    Major depressive disorder (MDD) is a common psychiatric disease. Selective serotonin reuptake inhibitors (SSRIs) are an important class of drugs used in the treatment of MDD. However, many patients do not respond adequately to SSRI therapy. We used a pharmacometabolomics-informed pharmacogenomic research strategy to identify citalopram/escitalopram treatment outcome biomarkers. Metabolomic assay of plasma samples from 20 escitalopram remitters and 20 nonremitters showed that glycine was negatively associated with treatment outcome (P = 0.0054). This observation was pursued by genotyping tag single-nucleotide polymorphisms (SNPs) for genes encoding glycine synthesis and degradation enzymes, using 529 DNA samples from SSRI-treated MDD patients. The rs10975641 SNP in the glycine dehydrogenase (GLDC) gene was associated with treatment outcome phenotypes. Genotyping for rs10975641 was carried out in 1,245 MDD patients in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, and its presence was significant (P = 0.02) in DNA taken from these patients. These results highlight a possible role for glycine in SSRI response and illustrate the use of pharmacometabolomics to "inform" pharmacogenomics.

  20. Effect of N fertilizer top-dressing at various reproductive stages on growth, N-2 fixation and yield of three soybean (Glycine max (L.) Merr.) genotypes

    NARCIS (Netherlands)

    Gan, YB; Stulen, [No Value; van Keulen, H; Kuiper, PJC

    2003-01-01

    Soybean (Glycine max (L.) Merr.) is one of the most important food and cash crops in China and a key protein source for the farmers in northern China. Previous experiments in both the field and greenhouse have shown that N-2 fixation alone cannot meet the N requirement for maximizing soybean yield,

  1. Effect of N fertilizer top-dressing at various reproductive stages on growth, N2 fixation and yield of three soybean (Glycine max (L.) Merr.) genotypes

    NARCIS (Netherlands)

    Gan, Y.B.; Stulen, I.; Kuiper, P.J.C.; Keulen, van H.

    2003-01-01

    Soybean (Glycine max (L.) Merr.) is one of the most important food and cash crops in China and a key protein source for the farmers in northern China. Previous experiments in both the field and greenhouse have shown that N2 fixation alone cannot meet the N requirement for maximizing soybean yield,

  2. Time-integrated CP violation measurements in the B mesons system at the LHCb experiment

    CERN Document Server

    Cardinale, R

    2016-01-01

    Time-integrated CP violation measurements in the B meson system provide information for testing the CKM picture of CP violation in the Standard Model. A review of recent results from the LHCb experiment is presented.

  3. Relations among questionnaire and experience sampling measures of inner speech: a smartphone app study

    OpenAIRE

    Ben eAlderson-Day; Charles eFernyhough

    2015-01-01

    Inner speech is often reported to be a common and central part of inner experience, but its true prevalence is unclear. Many questionnaire-based measures appear to lack convergent validity and it has been claimed that they overestimate inner speech in comparison to experience sampling methods (which involve collecting data at random timepoints). The present study compared self-reporting of inner speech collected via a general questionnaire and experience sampling, using data from a custom-mad...

  4. Experiments with a double solenoid system: Measurements of the 6He + p Resonant Scattering

    Directory of Open Access Journals (Sweden)

    Pampa Condori R.

    2014-03-01

    Full Text Available A recent experiment has been performed in the double solenoid system Radioactive Ion Beams in Brasil (RIBRAS by impinging a pure 6He secondary beam on a thick CH2 target to measure the 6He + p excitation function. Results of this experiment will be presented.

  5. Transgender Individuals' Workplace Experiences: The Applicability of Sexual Minority Measures and Models

    Science.gov (United States)

    Brewster, Melanie E.; Velez, Brandon; DeBlaere, Cirleen; Moradi, Bonnie

    2012-01-01

    The present study explored whether 3 existing measures of workplace constructs germane to the experiences of sexual minority people could be modified to improve their applicability with transgender individuals. To this end, the Workplace Heterosexist Experiences Questionnaire (WHEQ; C. R. Waldo, 1999); the Lesbian, Gay, Bisexual, and Transgendered…

  6. Measures of Effectiveness for Non-Lethal Weapons: Aligning Behavioral Experiments with Operational Success

    Science.gov (United States)

    2015-01-01

    Eastern exit: The noncombatant evacuation operation (NEO) from Mogadishu, Somalia, in January 1991 ( CRM 91-211). Alexandria, VA: Center for Naval...Measures of Effectiveness for Non- Lethal Weapons: Aligning Behavioral Experiments with Operational Success Shelley Cazares James Belanich Jeffrey A...Weapons: Aligning Behavioral Experiments with Operational Success Shelley Cazares, James Belanich, Jeffrey A. Snyder, P. M. Picucci, Jenny R. Holzer

  7. The FRO2 ferric reductase is required for glycine betaine's effect on chilling tolerance in Arabidopsis roots.

    Science.gov (United States)

    Einset, John; Winge, Per; Bones, Atle M; Connolly, Erin L

    2008-10-01

    FRO2 (At1g01580) codes for an NADPH-dependent ferric reductase in plasma membranes of root epidermal cells with a demonstrated role in iron uptake by plants. Ferric reductase activity has been shown to be the rate-limiting step for iron uptake in strategy I plants like Arabidopsis and in rice, but it has been unclear whether FRO genes have other physiological functions. We hypothesized that FRO2 was involved in chilling stress tolerance because its expression was upregulated by treatment of plants with glycine betaine (GB), a chemical that prevents reactive oxygen species (ROS) signaling in chilling stress. This idea was confirmed by showing that the FRO2 null mutant frd1-1 failed to respond to GB in chilling assays either in relation to root growth recovery or inhibition of ROS accumulation. Measurements of ferric reductase activity in wild-type plants treated with GB before chilling showed no significant GB effect compared with controls. In addition, 35S-FRO2 transgenics with elevated mRNA levels did not have improved chilling tolerance. However, ferric reductase activity in wild-type plants or 35S-FRO2 transgenics pretreated with GB was several-fold higher after chilling compared with non-pretreated controls. These experiments identify a new physiological function for FRO2, i.e. blocking ROS accumulation during chilling. They also suggest that GB has a major effect on FRO2 activity posttranscriptionally in the cold.

  8. Ligand binding by the tandem glycine riboswitch depends on aptamer dimerization but not double ligand occupancy

    Science.gov (United States)

    Ruff, Karen M.

    2014-01-01

    The glycine riboswitch predominantly exists as a tandem structure, with two adjacent, homologous ligand-binding domains (aptamers), followed by a single expression platform. The recent identification of a leader helix, the inclusion of which eliminates cooperativity between the aptamers, has reopened the debate over the purpose of the tandem structure of the glycine riboswitch. An equilibrium dialysis-based assay was combined with binding-site mutations to monitor glycine binding in each ligand-binding site independently to understand the role of each aptamer in glycine binding and riboswitch tertiary interactions. A series of mutations disrupting the dimer interface was used to probe how dimerization impacts ligand binding by the tandem glycine riboswitch. While the wild-type tandem riboswitch binds two glycine equivalents, one for each aptamer, both individual aptamers are capable of binding glycine when the other aptamer is unoccupied. Intriguingly, glycine binding by aptamer-1 is more sensitive to dimerization than glycine binding by aptamer-2 in the context of the tandem riboswitch. However, monomeric aptamer-2 shows dramatically weakened glycine-binding affinity. In addition, dimerization of the two aptamers in trans is dependent on glycine binding in at least one aptamer. We propose a revised model for tandem riboswitch function that is consistent with these results, wherein ligand binding in aptamer-1 is linked to aptamer dimerization and stabilizes the P1 stem of aptamer-2, which controls the expression platform. PMID:25246650

  9. The Hepatoprotection Provided by Taurine and Glycine against Antineoplastic Drugs Induced Liver Injury in an Ex Vivo Model of Normothermic Recirculating Isolated Perfused Rat Liver

    Directory of Open Access Journals (Sweden)

    Reza Heidari

    2016-03-01

    Full Text Available Taurine (2-aminoethane sulfonic acid is a non-protein amino acid found in high concentration in different tissues. Glycine (Amino acetic acid is the simplest amino acid incorporated in the structure of proteins. Several investigations indicate the hepatoprotective properties of these amino acids. On the other hand, antineoplastic agents-induced serum transaminase elevation and liver injury is a clinical complication. The current investigation was designed to screen the possible hepatoprotective properties of taurine and glycine against antineoplastic drugs-induced hepatic injury in an ex vivo model of isolated perfused rat liver. Rat liver was perfused with different concentration (10 μM, 100 μM and 1000 μM of antineoplastic drugs (Mitoxantrone, Cyclophosphamide, Cisplatin, 5 Fluorouracil, Doxorubicin and Dacarbazine via portal vein. Taurine and glycine were administered to drug-treated livers and liver perfusate samples were collected for biochemical measurements (ALT, LDH, AST, and K+. Markers of oxidative stress (reactive oxygen species formation, lipid peroxidation, total antioxidant capacity and glutathione were also assessed in liver tissue. Antineoplastic drugs caused significant pathological changes in perfusate biochemistry. Furthermore, markers of oxidative stress were significantly elevated in drug treated livers. It was found that taurine (5 and 10 mM and glycine (5 and 10 mM administration significantly mitigated the biomarkers of liver injury and attenuated drug induced oxidative stress. Our data indicate that taurine and glycine supplementation might help as potential therapeutic options to encounter anticancer drugs-induced liver injury.

  10. Sur quelques aspects de la production du soja (Glycine max L. au Congo : essais préliminaires

    Directory of Open Access Journals (Sweden)

    Mandimba, GR.

    1991-01-01

    Full Text Available About some cropping systems of soybean (Glycine max. L. in Congo : first results. Field experiments were conducted to assess the response of soybean Glycine max cv. FN3 to N fertilization and inoculation respectively. In the first experiment, the effects of different levels of N fertilizer (0 ; 20 ; 40 and 80 kg N/ha with or without liming were studied. Soybean podyield were related to N fertilization only when liming was added to the soil In the second one, the effects of four Bradyrhizobium japonicum strains F A3 ; 3-40 ; SA 1 and G3S on nodulation and yields were also studied. Inoculation has significant effect on nodulation and plant top dry weight at full bloom, and seed yield at harvest when compared to the control. However, the Bradyrhizobium japonicum strains tested had various symbiotic effectiveness on Glycine max cv. FN3. In addition, soybean plants inoculated with G3S strain and those fertilized with 100 kg N/ha produced similar seed yield. Our study illustrated that G3S strain had the better adaptability in environmental conditions of Congo soil.

  11. Radiolysis of amino acids by heavy and energetic cosmic ray analogues in simulated space environments: α-glycine zwitterion form

    Science.gov (United States)

    Portugal, Williamary; Pilling, Sergio; Boduch, Philippe; Rothard, Hermann; Andrade, Diana P. P.

    2014-07-01

    In this work, we studied the stability of the glycine molecule in the crystalline zwitterion form, known as α-glycine (+NH3CH2COO-), under the action of heavy cosmic ray analogues. The experiments were conducted in a high vacuum chamber at the heavy-ion accelerator Grand Accélérateur National d'Ions Lourds (GANIL), in Caen, France. The samples were bombarded at two temperatures (14 and 300 K) by 58Ni11+ ions of 46 MeV, up to a final fluence of 1013 ion cm-2. The chemical evolution of the sample was evaluated in situ using a Fourier Transform Infrared Spectrometer (FTIR). The bombardment at 14 K produced several daughter species, such as OCN-, CO, CO2 and CN-. The results also suggest the appearance of peptide bonds during irradiation, but this must be confirmed by further experiments. The half-life of glycine in the interstellar medium was estimated to be 7.8 × 103 yr (300 K) and 2.8 × 103 yr (14 K). In the Solar system, the values were 8.4 × 102 yr (300 K) and 3.6 × 103 yr (14 K). It is believed that glycine could be present in space environments that suffered aqueous changes, such as the interiors of comets, meteorites and planetesimals. This molecule is present in the proteins of all living beings. Therefore, studying its stability in these environments will provide further understanding of the role of this species in prebiotic chemistry on Earth.

  12. XPS/NEXAFS spectroscopic and conductance studies of glycine on AlGaN/GaN transistor devices

    Science.gov (United States)

    Myers, Matthew; Khir, Farah Liyana Muhammad; Home, Michael A.; Mennell, Christopher; Gillbanks, Jeremy; Tadich, Anton; Baker, Murray V.; Nener, Brett D.; Parish, Giacinta

    2018-03-01

    We report on a study using a combination of XPS/NEXAFS and conductivity measurements to develop a fundamental understanding of how dipolar molecules interact with the heterostructure device surface and affect the device conductivity of AlGaN/GaN heterostructure-based transistors. In such structures, which are increasingly being investigated for chemical and biological sensing, a 2-dimensional electron gas spontaneously forms at the layer interface that is sensitive to the charge characteristics of the exposed surface. Glycine, chosen for this study because it is the simplest of the amino acids and is known to form a zwitterionic configuration when stabilized through intermolecular interactions, was evaporated under ultra-high vacuum conditions onto the device surface and subsequently both XPS/NEXAFS and conductivity measurements were conducted. NEXAFS spectra show a preferential orientation for the Glycine molecules on the surface and evidence for both neutral and zwitterionic species on the surface. In situ conductivity measurements suggest that the negatively charged carboxylate group is closest to the surface. These results are a unique and pivotal contribution to the previous and at times conflicting literature on the zwitterionic nature of Glycine.

  13. On the measurement of solute concentrations in 2-D flow tank experiments

    Directory of Open Access Journals (Sweden)

    M. Konz

    2008-05-01

    Full Text Available In this study we describe and compare photometric and resistivity measurement methodologies to determine solute concentrations in porous media flow tank experiments. The first method is the photometric method, which directly relates digitally measured intensities of a tracer dye to solute concentrations, without first converting the intensities to optical densities. This enables an effective processing of a large number of images in order to compute concentration time series at various points of the flow tank and concentration contour lines. This paper investigates perturbations of the measurements; it was found both lens flare effects and image resolution were a major source of error. Attaching a mask minimizes the lens flare. The second method for in situ measurement of salt concentrations in porous media experiments is the resistivity method. The resistivity measurement system uses two different input voltages at gilded electrode sticks to enable the measurement of salt concentrations from 0 to 300 g/l. The method is highly precise and the major perturbations are caused by temperature changes, which can be controlled in the laboratory. The two measurement approaches are compared with regard to their usefulness in providing data for benchmark experiments aimed at improving process understanding and testing numerical codes. Due to the unknown measurement volume of the electrodes, we consider the image analysis method more appropriate for intermediate scale 2D laboratory benchmark experiments for the purpose of evaluating numerical codes.

  14. Impact of three-dimensional polarization profiles on spin-dependent measurements in colliding beam experiments

    Directory of Open Access Journals (Sweden)

    Wolfram Fischer

    2012-04-01

    Full Text Available We derive the effect of 3-dimensional polarization profiles on the measured polarization in polarimeters, as well as the observed polarization and the polarization-weighted luminosity (figure of merit in single and double spin measurements in colliding beam experiments. Applications to RHIC are discussed.

  15. Low Mass Vector Meson Measurements via Di-electrons at RHIC by the PHENIX Experiment

    CERN Document Server

    Sharma, Deepali

    2009-01-01

    The PHENIX experiment at RHIC has measured $\\omega$ and $\\phi$ mesons in $p+p$, $d+Au$ and $Au+Au$ collisions at \\sqn = 200 GeV via both hadronic and di-electron decay channels. The transverse momentum spectra as measured in different decay modes and at different centralities are shown and discussed here.

  16. The effect of noise in a performance measure on work motivation: A real effort laboratory experiment

    NARCIS (Netherlands)

    Sloof, R.; van Praag, C.M.

    2010-01-01

    This paper reports the results of an individual real effort laboratory experiment where subjects are paid for measured performance. Measured performance equals actual performance plus noise. We compare a stable environment where the noise is small with a volatile environment where the noise is

  17. The Quartz-Crystal Microbalance in an Undergraduate Laboratory Experiment: Measuring Mass

    Science.gov (United States)

    Tsionsky, Vladimir

    2007-01-01

    The study explains the quartz-crystal microbalance (QCM) technique, which is often used as an undergraduate laboratory experiment for measuring the mass of a system. QCM can be used as a mass sensor only when the measured mass is rigidly attached to the surface.

  18. The energy balance experiment EBEX-2000. Part III: Behaviour and quality of the radiation measurements

    NARCIS (Netherlands)

    Kohsiek, W.; Liebethal, C.; Foken, T.; Vogt, R.; Oncley, S.P.; Bernhofer, C.; Debruin, H.A.R.

    2007-01-01

    An important part of the Energy Balance Experiment (EBEX-2000) was the measurement of the net radiation and its components. Since the terrain, an irrigated cotton field, could not be considered homogeneous, radiation measurements were made at nine sites using a variety of radiation instruments,

  19. Measurement of 3-Axis Magnetic Fields Induced by Current Wires Using a Smartphone in Magnetostatics Experiments

    Science.gov (United States)

    Setiawan, B.; Septianto, R. D.; Suhendra, D.; Iskandar, F.

    2017-01-01

    This paper describes the use of an inexpensive smartphone's magnetic sensor to measure magnetic field components (B[subscript x], B[subscript y] and B[subscript z]) induced by current wires in magnetostatic experiments. The variable parameters used to measure the magnetic sensor's capabilities were: the geometrical shapes of the wire, current…

  20. Effects of copper glycine chelate on liver and faecal mineral concentrations, and blood parameters in broilers

    Directory of Open Access Journals (Sweden)

    Małgorzata Kwiecień

    2015-06-01

    Full Text Available The aim of the study was to determine the influence of Cu-glycine chelate on the chemical composition of the liver and blood parameters of broiler chickens. A total of 250 one-day-old Ross 308 male chicks were allotted into 5 groups with 5 replicates of 10 birds each. Rearing of birds lasted 42 days. In the experiment Cu was added to the premix in the form of CuSO4 (16 mg, 8 mg Cu, and in the form of Cu glycine chelate (16 mg, 8 mg, 4 mg Cu. The parameters in the chickens’ blood remained within the range of physiological norms when lower levels of the analyzed elements were added. Adding lower levels of Cu (8 or 4 mg·kg-1 in comparison with the recommended doses (16 mg·kg-1 for broilers, in the form of highly assimilable organic sources, did not reduce the content of minerals Cu, Fe, and Zn in the chickens’ liver, but reduced the faecal Fe, Cu and Zn concentrations compared to CuSO4.

  1. [Inheritance of resistance to Heterodera glycines race 14 in Huibuzhi black bean].

    Science.gov (United States)

    Wang, Y T; Peng, D L; Chen, S Y

    2000-01-01

    Heterodera glycines is the most serious disease in the world soybean (Glycine max) production. Huibuzhi black bean from Xing County in Shanxi Province, China is one of the most important resistant resources. Using a set of host differentials for soybean cyst nematode and criterion of race classification as well as method of manual inoculation, race 14 was identified as a prevalent one in the soil population of the Experiment Station, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing. A sensitive variety #7 Jidou as a female donor crossed with Huibuzhi black bean. Their offsprings were investigated for resistance to race 14. Two of F1 seedlings demonstrated their resistant. Two populations in F2 including 116 seedlings and 78 seedlings in each one appeared their own separate ratio that was in common: 43R:21S. A genetic hypothesis was proposed that resistance to SCN race 14 in Huibuzhi black bean was controlled by three gene pairs arose. Gene reciprocity existed among them: one recessive epistasis gene pair and two dominant complementary gene pairs. Random 30 families in F3 including 10-15 tested seedlings in each family were screened for resistance to SCN race 14. The segregate ratio, 19R:38Seg.:7S, among F3 families confirmed that the presented genetic hypothesis was correct.

  2. Extraction optimization, preliminary characterization and antioxidant activities of polysaccharides from Glycine soja.

    Science.gov (United States)

    Jing, Changliang; Yuan, Yuan; Tang, Qi; Zou, Ping; Li, Yiqiang; Zhang, Chengsheng

    2017-10-01

    Single-factor experiment and Central Composite Design (CCD) was applied to optimize the ultrasound-assisted extraction (UAE) conditions of polysaccharides from Glycine soja (CGPS), and a preliminary characterization of three polysaccharide fractions (CGPS, GPS-1, and GPS-2) and their antioxidant activities were investigated. Under the optimal conditions: ratio of liquid to solid 42.7mL/g, extraction power 293.7W, extraction temperature 68.9°C, and extraction time 34.7min, the experimental CGPS yield was 6.04mg/g. CGPS was further purified by DEAE-cellulose and Sephadex-100 chromatography to obtain two fractions (GPS-1 and GPS-2), and their monosaccharides compositions were characterized by HPLC. Fourier-transform infrared spectra (FT-IR) indicated the chemical structures of them. Moreover, they exhibited high antioxidant activities in a concentration-dependent manner in vitro. In summary, the present study suggested that UAE was a very effective method to extract polysaccharides from Glycine soja and the polysaccharides could be explored as potential antioxidant agents for medicine and function food. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration

    Directory of Open Access Journals (Sweden)

    Ariel Avila

    2013-08-01

    Full Text Available Glycine receptors (GlyRs are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis.

  4. The experience in monitoring pennalties and alternative measures: the case of the NUMOPA/CEAPA/NUAPA

    Directory of Open Access Journals (Sweden)

    Sandra regina de abreu Pires

    2014-06-01

    Full Text Available The present text aimed to show an experience with the monitoring of the execution of the penalties and alternative measures developed in the Londrina – Paraná region, through the projects Londrina’s Center for Alternative Sentencing Monitoring, Center for Alternative Sentencing Monitoring of Arapongas; Central Monitoring and Sentencing Alternative Measures and Center for Monitoring and Sentencing Alternative Measures of Cambé. The text if initiates with some notes on sentencing alternative measures in view of allowing the visualization of the thematic context of the experience. After that, it contemplates the experience directly, telling first the trajectory covered for, continuous act, to summarily approach some elements of the work methodology. It finishes with a mention to some of the gotten positive results with the developed work.

  5. Synthesis and Characterization of Copper (II) Complex of Glycine ...

    African Journals Online (AJOL)

    Copper(II)Complex of amino acid was synthesized by refluxing the mixtures of ethanolic solutions of glycine and copper(II)chloride. The complex compound was characterized by melting point (225oC), PH 5.78 at 28oC, moisture content of 5% with a yield of 68%. The compound is insoluble in water but readily soluble in ...

  6. Thermal effects of carbonated hydroxyapatite modified by glycine and albumin

    OpenAIRE

    Gerk, S. A.; Golovanova, O. A.; Kuimova, Marina Valerievna

    2017-01-01

    In this work calcium phosphate powders were obtained by precipitation method from simulated solutions of synovial fluid containing glycine and albumin. X-ray diffraction and IR spectroscopy determined that all samples are single-phase and are presented by carbonate containing hydroxyapatite (CHA). The thermograms of solid phases of CHA were obtained and analyzed; five stages of transformation in the temperature range of 25-1000°C were marked. It is shown that in this temperature range dehydra...

  7. Glycine receptor mouse mutants: model systems for human hyperekplexia.

    Science.gov (United States)

    Schaefer, Natascha; Langlhofer, Georg; Kluck, Christoph J; Villmann, Carmen

    2013-11-01

    Human hyperekplexia is a neuromotor disorder caused by disturbances in inhibitory glycine-mediated neurotransmission. Mutations in genes encoding for glycine receptor subunits or associated proteins, such as GLRA1, GLRB, GPHN and ARHGEF9, have been detected in patients suffering from hyperekplexia. Classical symptoms are exaggerated startle attacks upon unexpected acoustic or tactile stimuli, massive tremor, loss of postural control during startle and apnoea. Usually patients are treated with clonazepam, this helps to dampen the severe symptoms most probably by up-regulating GABAergic responses. However, the mechanism is not completely understood. Similar neuromotor phenotypes have been observed in mouse models that carry glycine receptor mutations. These mouse models serve as excellent tools for analysing the underlying pathomechanisms. Yet, studies in mutant mice looking for postsynaptic compensation of glycinergic dysfunction via an up-regulation in GABAA receptor numbers have failed, as expression levels were similar to those in wild-type mice. However, presynaptic adaptation mechanisms with an unusual switch from mixed GABA/glycinergic to GABAergic presynaptic terminals have been observed. Whether this presynaptic adaptation explains the improvement in symptoms or other compensation mechanisms exist is still under investigation. With the help of spontaneous glycine receptor mouse mutants, knock-in and knock-out studies, it is possible to associate behavioural changes with pharmacological differences in glycinergic inhibition. This review focuses on the structural and functional characteristics of the various mouse models used to elucidate the underlying signal transduction pathways and adaptation processes and describes a novel route that uses gene-therapeutic modulation of mutated receptors to overcome loss of function mutations. © 2013 The British Pharmacological Society.

  8. Flow Experience as a Quality Measure in Evaluating Physically Activating Collaborative Serious Games

    Directory of Open Access Journals (Sweden)

    Kristian J. M. Kiili

    2014-09-01

    Full Text Available The measurement of the subjective playing experience is important part of the game development process. The enjoyment level that a serious game offers is a key factor in determining whether a player will be engaged in the gameplay and achieve the objectives of the game. In this paper we report the results of a game design process in which two prototypes of a collaborative exergame were studied. The main aim of the paper is to explore to what extend the measurement of flow experience can facilitate the game evaluation and design process. Alltogether 102 junior high school students participated in two user experience studies and played collaborative exergames designed to teach soft skills. Playing experience was measured with a flow questionnaire, playing behavior was observed and some of the players were interviewed. The results showed that flow experience can be used to evaluate the overall quality of the gameplay and it provides a structured approach to consider the quality of the game. However, flow does not provide detailed information about the shortages of the game and thus complementary methods is needed to identify the causes. The results also indicated that flow experience was independent of gender that supports its use in quality measurement.

  9. Heterodera glycines cysts contain an extensive array of endoproteases as well as inhibitors of proteases in H. glycines and Meloidogyne incognita infective juvenile stages

    Science.gov (United States)

    Heterodera glycines cysts contain proteases, and inhibitors of protease activities in various nematode species. In this investigation, proteases in H. glycines cysts were identified using a commercially available FRET-peptide library comprising 512 peptide pools qualified to detect up to 4 endoprot...

  10. The Structure and Measurement of Unusual Sensory Experiences in Different Modalities: The Multi-Modality Unusual Sensory Experiences Questionnaire (MUSEQ

    Directory of Open Access Journals (Sweden)

    Claire A. A. Mitchell

    2017-08-01

    Full Text Available Hallucinations and other unusual sensory experiences (USE can occur in all modalities in the general population. Yet, the existing literature is dominated by investigations into auditory hallucinations (“voices”, while other modalities remain under-researched. Furthermore, there is a paucity of measures which can systematically assess different modalities, which limits our ability to detect individual and group differences across modalities. The current study explored such differences using a new scale, the Multi-Modality Unusual Sensory Experiences Questionnaire (MUSEQ. The MUSEQ is a 43-item self-report measure which assesses USE in six modalities: auditory, visual, olfactory, gustatory, bodily sensations, and sensed presence. Scale development and validation involved a total of 1,300 participants, which included: 513 students and community members for initial development, 32 individuals with schizophrenia spectrum disorder or bipolar disorder for validation, 659 students for factor replication, and 96 students for test-retest reliability. Confirmatory factor analyses showed that a correlated-factors model and bifactor model yielded acceptable model fit, while a unidimensional model fitted poorly. These findings were confirmed in the replication sample. Results showed contributions from a general common factor, as well as modality-specific factors. The latter accounted for less variance than the general factor, but could still detect theoretically meaningful group differences. The MUSEQ showed good reliability, construct validity, and could discriminate non-clinical and clinical groups. The MUSEQ offers a reliable means of measuring hallucinations and other USE in six different modalities.

  11. A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids.

    Science.gov (United States)

    Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; van der Sluis, Rencia; Nortje, Carla; van Dijk, Alberdina Aike

    2014-08-01

    A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the water solubility of organic acids in order to facilitate urinary excretion. However, the recently proposed glycine deportation hypothesis states that the role of the amino acid conjugations, including glycine conjugation, is to regulate systemic levels of amino acids that are also utilized as neurotransmitters in the central nervous systems of animals. This hypothesis is based on the observation that, compared to glucuronidation, glycine conjugation does not significantly increase the water solubility of aromatic acids. In this review it will be argued that the major role of glycine conjugation is to dispose of the end products of phenylpropionate metabolism. Furthermore, glucuronidation, which occurs in the endoplasmic reticulum, would not be ideal for the detoxification of free benzoate, which has been shown to accumulate in the mitochondrial matrix. Glycine conjugation, however, prevents accumulation of benzoic acid in the mitochondrial matrix by forming hippurate, a less lipophilic conjugate that can be more readily transported out of the mitochondria. Finally, it will be explained that the glycine conjugation of benzoate, a commonly used preservative, exacerbates the dietary deficiency of glycine in humans. Because the resulting shortage of glycine can negatively influence brain neurochemistry and the synthesis of collagen, nucleic acids, porphyrins, and other important metabolites, the risks of using benzoate as a preservative should not be underestimated.

  12. Degradation of Glyphosate by Mn-Oxide May Bypass Sarcosine and Form Glycine Directly after C-N Bond Cleavage.

    Science.gov (United States)

    Li, Hui; Wallace, Adam F; Sun, Mingjing; Reardon, Patrick; Jaisi, Deb P

    2018-02-06

    Glyphosate is the active ingredient of the common herbicide Roundup. The increasing presence of glyphosate and its byproducts has raised concerns about its potential impact on the environment and human health. In this research, we investigated abiotic pathways of glyphosate degradation as catalyzed by birnessite under aerobic and neutral pH conditions to determine whether certain pathways have the potential to generate less harmful intermediate products. Nuclear magnetic resonance (NMR) spectroscopy and high-performance liquid chromatography (HPLC) were utilized to identify and quantify reaction products, and density functional theory (DFT) calculations were used to investigate the bond critical point (BCP) properties of the C-N bond in glyphosate and Mn(IV)-complexed glyphosate. We found that sarcosine, the commonly recognized precursor to glycine, was not present at detectable levels in any of our experiments despite the fact that its half-life (∼13.6 h) was greater than our sampling intervals. Abiotic degradation of glyphosate largely followed the glycine pathway rather than the AMPA (aminomethylphosphonic acid) pathway. Preferential cleavage of the phosphonate adjacent C-N bond to form glycine directly was also supported by our BCP analysis, which revealed that this C-N bond was disproportionately affected by the interaction of glyphosate with Mn(IV). Overall, these results provide useful insights into the potential pathways through which glyphosate may degrade via relatively benign intermediates.

  13. Long Term Sorption Diffusion Experiment (LTDE-SD). Performance of main in situ experiment and results from water phase measurements

    Energy Technology Data Exchange (ETDEWEB)

    Widestrand, Henrik; Byegaard, Johan; Nilsson, Kersti; Hoeglund, Susanne; Gustafsson, Erik (Geosigma AB, Uppsala (Sweden)); Kronberg, Magnus (Swedish Nuclear Fuel and Waste Management Co. (Sweden))

    2010-12-15

    radionuclide sorption to colloids in the aqueous phase was of minor importance. Furthermore, the measurements performed after a general colloid filtration showed no significant concentrations of inorganic colloids. The natural redox conditions were difficult to maintain during the experiment. Therefore the experiment was performed under the oxidizing conditions (E{sub h} approx470 mV) that was obtained during the circulation of the groundwater. Sorption occurred on equipment during the experiment, in particular for some surface complexation sorbing tracers, possibly due to iron-oxy-hydroxides formed on equipment surfaces. Quantification was made of the amount of sorption on the equipment in order to enable corrections in the evaluation procedures. The sorption occurring for ion-exchange sorbing tracers was concluded to predominately be an effect of interaction with the geologic material since the sorbed amount on the equipment was found to be insignificant. Natural pressure conditions were maintained throughout the experiment time and consequently penetration into the rock matrix must be considered as a result only of diffusion since no advection could have been involved. Modelling in order to determine sorption coefficients (K{sub a}, K{sub d}) was performed using a homogeneous porosity sorption-diffusion model using fixed data for porosity and matrix diffusivity from laboratory investigations on LTDE-SD core materials. For the ion-exchange sorbing tracers, the in situ evaluated K{sub d} was in the range of the batch sorption results or near the highest values (fracture material) from the batch sorption results. This indicates that a sorption-diffusion model can describe the concentration losses reasonably well for the ion-exchange sorbing tracers. However, due to the sorption on equipment, one should treat these results with care and consider the analysis of the sampled rock material before any definitive conclusions can be made based on the actual penetration profiles of

  14. A brief review of measurements of electroweak bosons at the LHCb experiment in LHC Run 1

    CERN Document Server

    INSPIRE-00340962

    2016-09-15

    The LHCb experiment is one of four major experiments at the LHC. Despite being designed for the study of beauty and charm particles, it has made important contributions in other areas, such as the production and decay of $W$ and $Z$ bosons. Such measurements can be used to study and constrain parton distribution functions, as well as to test perturbative quantum chromodynamics in hard scattering processes. The angular structure of $Z$ boson decays to leptons can also be studied and used to measure the weak mixing angle. The phase space probed by LHCb is particularly sensitive to this quantity, and the LHCb measurement using the dimuon final state is currently the most precise determination of $\\sin^2\\theta^\\text{lept.}_\\text{eff.}$ at the LHC. LHCb measurements made using data collected during the first period of LHC operations (LHC Run 1) are discussed in this review. The article also considers the potential impact of related future measurements.

  15. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation1234

    Science.gov (United States)

    Patel, Sanjeet G; Guthikonda, Anuradha P; Reid, Marvin; Balasubramanyam, Ashok; Taffet, George E; Jahoor, Farook

    2011-01-01

    Background: Aging is associated with oxidative stress, but underlying mechanisms remain poorly understood. Objective: We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress. Design: Eight elderly and 8 younger subjects received stable-isotope infusions of [2H2]glycine, after which red blood cell (RBC) glutathione synthesis and concentrations, plasma oxidative stress, and markers of oxidant damage (eg, F2-isoprostanes) were measured. Elderly subjects were restudied after 2 wk of glutathione precursor supplementation. Results: Compared with younger control subjects, elderly subjects had markedly lower RBC concentrations of glycine (486.7 ± 28.3 compared with 218.0 ± 23.7 μmol/L; P glutathione (2.08 ± 0.12 compared with 1.12 ± 0.18 mmol/L RBCs; P glutathione fractional (83.14 ± 6.43% compared with 45.80 ± 5.69%/d; P glutathione concentration, a 78.8% higher fractional synthesis rate, a 230.9% higher absolute synthesis rate, and significantly lower plasma oxidative stress and F2-isoprostanes. No differences in these measures were observed between younger subjects and supplemented elderly subjects. Conclusions: Glutathione deficiency in elderly humans occurs because of a marked reduction in synthesis. Dietary supplementation with the glutathione precursors cysteine and glycine fully restores glutathione synthesis and concentrations and lowers levels of oxidative stress and oxidant damages. These findings suggest a practical and effective approach to decreasing oxidative stress in aging. PMID:21795440

  16. Functional properties of spontaneous IPSCs and glycine receptors in rod amacrine (AII) cells in the rat retina.

    Science.gov (United States)

    Gill, Silje Bakken; Veruki, Margaret Lin; Hartveit, Espen

    2006-09-15

    AII amacrine cells play a crucial role in retinal signal transmission under scotopic conditions. We have used rat retinal slices to investigate the functional properties of inhibitory glycine receptors on AII cells by recording spontaneous IPSCs (spIPSCs) in whole cells and glycine-evoked responses in outside-out patches. Glycinergic spIPSCs displayed fast kinetics with an average 10-90% rise time of approximately 500 mus, and a decay phase best fitted by a double-exponential function with tau(fast) approximately 4.8 ms (97.5% amplitude contribution) and tau(slow) approximately 33 ms. Decay kinetics were voltage dependent. Ultrafast application of brief ( approximately 2-5 ms) pulses of glycine (3 mm) to patches, evoked responses with fast deactivation kinetics best fitted with a double-exponential function with tau(fast) approximately 4.6 ms (85% amplitude contribution) and tau(slow) approximately 17 ms. Double-pulse experiments indicated recovery from desensitization after a 100-ms pulse of glycine with a double-exponential time course (tau(fast) approximately 71 ms and tau(slow) approximately 1713 ms). Non-stationary noise analysis of spIPSCs and patch responses, and directly observed channel gating yielded similar single-channel conductances ( approximately 41 to approximately 47 pS). In addition, single-channel gating occurred at approximately 83 pS. These results suggest that the fast glycinergic spIPSCs in AII cells are probably mediated by alpha1beta heteromeric receptors with a contribution from alpha1 homomeric receptors. We hypothesize that glycinergic synaptic input may target the arboreal dendrites of AII cells, and could serve to shunt excitatory input from rod bipolar cells and transiently uncouple the transcellular current through electrical synapses between AII cells and between AII cells and ON-cone bipolar cells.

  17. Development and psychometric testing of an instrument to measure the patient’s experience of external radiotherapy: The Radiotherapy Experience Questionnaire (RTEQ

    Directory of Open Access Journals (Sweden)

    Kristina Olausson

    2017-09-01

    Conclusion: The RT Experience Questionnaire is a tentatively valid and reliable instrument to measure how patients experience the external RT session process and the environment in the treatment room.

  18. Facile electrosynthesis and characterization of superparamagnetic nanoparticles coated with cysteine, glycine and glutamine

    Science.gov (United States)

    Aghazadeh, Mustafa; Karimzadeh, Isa; Doroudi, Taher; Ganjali, Mohammad Reza; Kolivand, Peir Hossein; Gharailou, Davoud

    2017-08-01

    A novel and facile strategy has been developed for the preparation of cysteine-, glycine- and glutamine-coated magnetite nanoparticles (MNPs). According to this strategy, Fe3O4 nanoparticles were electrodeposited from an aqueous electrolyte containing a dissolved iron salt and amino acids. A simple deposition mode i.e., constant current and two-electrode set-up was used in the electrosynthesis procedure. The magnetite phase of the deposited nanoparticles was confirmed through XRD and FT-IR analyses. Morphological observations through FE-SEM and TEM confirmed the formation of spherical MNP particles with an average size of 10 nm. The formation of cysteine, glycine and glutamine layers on the surface of the electro-synthesized particles was proved based on FT-IR, DLS and TG data. Vibrating sample magnetometery (VSM) measurements confirmed the prepared iron oxide nanoparticles to have a super-paramagnetic nature, since they exhibit a high saturation magnetization (Ms ≈ 58 emu g-1), as well as, negligible remnant magnetization (Mr) and coercivity (Ce). Based on the obtained results, the proposed platform can be considered as a fast, simple and efficient method for the preparation of surface-coated magnetite nanoparticles.

  19. Highly resolved HSQC experiments for the fast and accurate measurement of homonuclear and heteronuclear coupling constants

    Science.gov (United States)

    Souza, Alexandre A.; Gil, Roberto R.; Parella, Teodor

    2017-09-01

    A number of J-upscaled NMR experiments are currently available to measure coupling constants along the indirect F1 dimension of a 2D spectrum. A major drawback is the limited F1 digital resolution that requires long acquisition times in order to achieve reasonably accurate measures. Here is shown how high levels of F1 digital resolution in a multiple-purpose HSQC experiment can be easily achieved by implementing a general J/δ-scaling strategy. In particular, a set of new J-resolved HSQC experiments is presented for a faster and much more accurate J determination in small molecules. Several options and practical aspects are discussed and exemplified by measuring the magnitude and/or the sign of several homo- and heteronuclear coupling constants in one shot.

  20. First high-voltage measurements using Ca+ ions at the ALIVE experiment

    Science.gov (United States)

    König, K.; Geppert, Ch.; Krämer, J.; Maaß, B.; Otten, E. W.; Ratajczyk, T.; Nörtershäuser, W.

    2017-11-01

    Many physics experiments depend on accurate high-voltage measurements to determine for example the exact retardation potential of an electron spectrometer as in the KATRIN experiment or the acceleration voltage of the ions at ISOL facilities. Until now only precision high-voltage dividers can be used to measure voltages up to 65 kV with an accuracy of 1 ppm. However, these dividers need frequent calibration and cross-checking and the direct traceability is not given. In this article we will describe the status of an experiment which aims to measure high voltages using collinear laser spectroscopy and which has the potential to provide a high-voltage standard and hence, a calibration source for precision high-voltage dividers on the 1 ppm level.

  1. First high-voltage measurements using Ca{sup +} ions at the ALIVE experiment

    Energy Technology Data Exchange (ETDEWEB)

    König, K., E-mail: kkoenig@ikp.tu-darmstadt.de [Technische Universität Darmstadt, Institut für Kernphysik (Germany); Geppert, Ch. [Universität Mainz, Institut für Kernchemie (Germany); Krämer, J.; Maaß, B. [Technische Universität Darmstadt, Institut für Kernphysik (Germany); Otten, E. W. [Universität Mainz, Institut für Physik (Germany); Ratajczyk, T.; Nörtershäuser, W. [Technische Universität Darmstadt, Institut für Kernphysik (Germany)

    2017-11-15

    Many physics experiments depend on accurate high-voltage measurements to determine for example the exact retardation potential of an electron spectrometer as in the KATRIN experiment or the acceleration voltage of the ions at ISOL facilities. Until now only precision high-voltage dividers can be used to measure voltages up to 65 kV with an accuracy of 1 ppm. However, these dividers need frequent calibration and cross-checking and the direct traceability is not given. In this article we will describe the status of an experiment which aims to measure high voltages using collinear laser spectroscopy and which has the potential to provide a high-voltage standard and hence, a calibration source for precision high-voltage dividers on the 1 ppm level.

  2. Ciclo de vida de Heterodera glycines raça 9 em soja no Estado do Maranhão Life cycle of the Heterodera glycines race 9 on soybean in Maranhão State, Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Pereira Cunha

    2008-09-01

    Full Text Available O nematóide de cisto da soja, Heterodera glycines, causa consideráveis reduções de produtividade à cultura da soja. Ocorrem 11 raças do NCS no Brasil e, no Maranhão, há registro somente da raça 9. O objetivo deste trabalho foi estabelecer o ciclo de vida de uma população de H. glycines raça 9, em soja, sob condições de clima tropical. O ensaio foi conduzido em casa-de-vegetação telada, no Campo Experimental da Embrapa Soja, em Balsas, Maranhão. As médias de temperaturas neste período foram de 28,7 °C no solo e 31,7 °C no ar e a média da umidade relativa do ar foi de 49,8 %. Plântulas de soja BRS Sambaíba foram transplantadas para vasos contendo solo areno-argiloso infestado com 4000 ovos de H. glycines raça 9. Foram avaliados os números de fêmeas e de cistos por sistema radicular aos 17, 20, 23, 26, 29 e 32 dias após a infestação. O número médio de fêmeas por sistema radicular de soja aumentou significativamente entre o 17º e o 29º dia após a infestação do solo, diminuindo no 32º dia, quando começaram a surgir os primeiros cistos. Nas condições testadas, H. glycines raça 9 completou o ciclo de vida em 29 dias após a infestação do solo. Desta forma, é possível a ocorrência de 3 a 4 gerações do nematóide durante o ciclo da soja em Balsas, Maranhão.The soybean cyst nematode Heterodera glycines causes great yield losses to soybean in Brazil. There are 11 races occurring in Brazil and, in the Maranhão State, only the race 9 was reported. The objective of this work was to establish the life cycle of a H. glycines race 9 population, on soybean, under tropical weather conditions. The experiment was carried out on a wired greenhouse at Embrapa Soybean - Balsas Experimental Station, Maranhão, Brazil. The average temperature was 28,7 ºC in the soil and 31,7 ºC in the air, and the relative humidity of the air was 49,8 %. Seedlings of soybean cultivar BRS Sambaíba were transferred to pots containing

  3. The influence of vocal training and acting experience on measures of voice quality and emotional genuineness

    Directory of Open Access Journals (Sweden)

    Steven Robert Livingstone

    2014-03-01

    Full Text Available Vocal training through singing and acting lessons is known to modify acoustic parameters of the voice. While the effects of singing training have been well documented, the role of acting experience on the singing voice remains unclear. In two experiments, we used linear mixed models to examine the relationships between the relative amounts of acting and singing experience on the acoustics and perception of the male singing voice. In Experiment 1, twelve male vocalists were recorded while singing with five different emotions, each with two intensities. Acoustic measures of pitch accuracy, jitter, and harmonics-to-noise (HNR ratio were examined. Decreased pitch accuracy and increased jitter, indicative of a lower ‘voice quality’, were associated with more years of acting experience, while increased pitch accuracy was associated with more years of singing lessons. We hypothesized that the acoustic deviations exhibited by more experienced actors was an intentional technique to increase the genuineness or truthfulness of their emotional expressions. In Experiment 2, listeners rated vocalists’ emotional genuineness. Vocalists with more years of acting experience were rated as more genuine than vocalists with less acting experience. No relationship was reported for singing training. Increased genuineness was associated with decreased pitch accuracy, increased jitter, and a higher harmonics-to-noise ratio. These effects may represent a shifting of priorities by male vocalists with acting experience to emphasize emotional genuineness over pitch accuracy or voice quality in their singing performances.

  4. The influence of vocal training and acting experience on measures of voice quality and emotional genuineness

    Science.gov (United States)

    Livingstone, Steven R.; Choi, Deanna H.; Russo, Frank A.

    2014-01-01

    Vocal training through singing and acting lessons is known to modify acoustic parameters of the voice. While the effects of singing training have been well documented, the role of acting experience on the singing voice remains unclear. In two experiments, we used linear mixed models to examine the relationships between the relative amounts of acting and singing experience on the acoustics and perception of the male singing voice. In Experiment 1, 12 male vocalists were recorded while singing with five different emotions, each with two intensities. Acoustic measures of pitch accuracy, jitter, and harmonics-to-noise ratio (HNR) were examined. Decreased pitch accuracy and increased jitter, indicative of a lower “voice quality,” were associated with more years of acting experience, while increased pitch accuracy was associated with more years of singing lessons. We hypothesized that the acoustic deviations exhibited by more experienced actors was an intentional technique to increase the genuineness or truthfulness of their emotional expressions. In Experiment 2, listeners rated vocalists’ emotional genuineness. Vocalists with more years of acting experience were rated as more genuine than vocalists with less acting experience. No relationship was reported for singing training. Increased genuineness was associated with decreased pitch accuracy, increased jitter, and a higher HNR. These effects may represent a shifting of priorities by male vocalists with acting experience to emphasize emotional genuineness over pitch accuracy or voice quality in their singing performances. PMID:24639659

  5. Processing Differences between Descriptions and Experience: A comparative Analysis using Eye-Tracking and Physiological Measures

    Directory of Open Access Journals (Sweden)

    Andreas eGlöckner

    2012-06-01

    Full Text Available Do decisions from description and from experience trigger different cognitive processes? We investigated this general question using cognitive modeling, eye-tracking, and physiological arousal measures. Three novel findings indeed suggest qualitatively different processes between the two types of decisions. First, comparative modeling indicates that evidence accumulation models assuming averaging of all fixation-sampled outcomes predict choices best in decisions from experience, whereas Cumulative Prospect Theory predicts choices best in decisions from descriptions. Second, arousal decreased with increasing difference in expected value between gambles in description-based choices but not in experience. Third, the relation between attention and subjective weights given to outcomes was stronger for experience-based than for description-based tasks. Overall, our results indicate that processes in experience-based risky choice can be captured by sampling-and-averaging evidence accumulation model. This model cannot be generalized to description-based decisions, in which more complex mechanisms are involved.

  6. The QMAP and MAT/TOCO Experiments for Measuring Anisotropy in the Cosmic Microwave Background

    OpenAIRE

    Miller, A.; Beach, J.; S Bradley; Devlin, M J; Caldwell, R.; Chapman, H; Dorwart, W. B.; Herbig, T.; Jones, D.; Monnelly, G.; Netterfield, C.B.; Nolta, M.; Page, L. A.; Puchalla, J.; Robertson, T.

    2001-01-01

    We describe two related experiments that measured the anisotropy in the cosmic microwave background (CMB). QMAP was a balloon-borne telescope that flew twice in 1996, collecting data on degree angular scales with an array of six high electron mobility transistor-based amplifiers (HEMTs). QMAP was the first experiment to use an interlocking scan strategy to directly produce high signal-to-noise CMB maps. The QMAP gondola was then refit for ground based work as the MAT/TOCO experiment. Observat...

  7. Measurements of very forward particles production spectra at LHC: the LHCf experiment

    CERN Document Server

    Berti, Eugenio; Bonechi, Lorenzo; Bongi, Massimo; Castellini, Guido; D'Alessandro, Raffaello; Haguenauer, Maurice; Itow, Yoshitaka; Iwata, Taiki; Kasahara, Katsuaki; Makino, Yuya; Masuda, Kimiaki; Matsubayashi, Eri; Menjo, Hiroaki; Muraki, Yasushi; Papini, Paolo; Ricciarini, Sergio; Sako, Takashi; Suzuki, Takuya; Tamura, Tadahisa; Tiberio, Alessio; Torii, Shoji; Tricomi, Alessia; Turner, W C; Ueno, Mana; Zhou, Qi Dong

    2017-01-01

    Thanks to two small sampling calorimeters installed in the LHC tunnel at ±140 m from IP1, the LHC forward (LHCf) experiment is able to detect neutral particles produced by high energy proton-ion collisions in the very forward region (pseudo-rapidity η > 8.4). The main aim of LHCf is to provide precise measurements of the production spectra relative to these particles, in order to tune hadronic interaction models used by ground-based cosmic rays experiments. In this paper we will present the current status of the LHCf experiment, regarding in particular collected data and analysis results, as well as future prospects

  8. Strategic B2B customer experience management: the importance of outcomes-based measures

    OpenAIRE

    Zolkiewski, Judy; Story, Victoria; Burton, Jamie; Chan, Paul; Gomes, Andre; Hunter-Jones, Philippa; O’Malley, Lisa; Peters, Linda D.; Raddats, Chris; Robinson, William

    2017-01-01

    Purpose\\ud \\ud The purpose of this paper is to critique the adequacy of efforts to capture the complexities of customer experience in a business-to-business (B2B) context using input–output measures. The paper introduces a strategic customer experience management framework to capture the complexity of B2B service interactions and discusses the value of outcomes-based measurement.\\ud Design/methodology/approach\\ud \\ud This is a theoretical paper that reviews extant literature related to B2B cu...

  9. On-site underground background measurements for the KASKA reactor-neutrino experiment

    Science.gov (United States)

    Furuta, H.; Sakuma, K.; Aoki, M.; Fukuda, Y.; Funaki, Y.; Hara, T.; Haruna, T.; Ishihara, N.; Katsumata, M.; Kawasaki, T.; Kuze, M.; Maeda, J.; Matsubara, T.; Matsumoto, T.; Miyata, H.; Nagasaka, Y.; Nakagawa, T.; Nakajima, N.; Nitta, K.; Sakai, K.; Sakamoto, Y.; Suekane, F.; Sumiyoshi, T.; Tabata, H.; Tamura, N.; Tsuchiya, Y.

    2006-12-01

    On-site underground background measurements were performed for the planned reactor-neutrino oscillation experiment KASKA at Kashiwazaki-Kariwa nuclear power station in Niigata, Japan. A small-diameter boring hole was excavated down to 70 m underground level, and a detector unit for γ-ray and cosmic-muon measurements was placed at various depths to take data. The data were analyzed to obtain abundance of natural radioactive elements in the surrounding soil and rates of cosmic muons that penetrate the overburden. The results will be reflected in the design of the KASKA experiment.

  10. Cerebrospinal fluid glycine in nonketotic hyperglycinemic: effect of treatment with sodium benzoate and a ventricular shunt.

    Science.gov (United States)

    Krieger, I; Winbaum, E S; Eisenbrey, A B

    1977-05-01

    In three infants with nonketotic hyperglycinemia, glycine was increased three-to fourfold in plasma, 13- to 28-fold in lumbar spinal fluid, and was higher yet in ventricular fluid. Oral sodium benzoate lowered cerebrospinal fluid (CSF) glycine by greater than 40%, but did not change the abnormal plasma: CSF ratio. An adult control, made hyperglycinemic with oral glycine, had a normal plasma: CSF ratio. Treatment of one patient with sodium benzoate from birth did not prevent mental retardation; the degree of brain stem depression was a function of CSF glycine in another patient. The persistance of glycine elevation in CSF, although therapy maintained normal concentration in plasma, appears to be caused by overproduction in brain and limitation of the high-capacity lumbar spinal reabsorptive mechanism. Treatment through lowering of CNS glycine by use of a ventricular shunt was explored.

  11. Using High-Fidelity Computational Fluid Dynamics to Help Design a Wind Turbine Wake Measurement Experiment

    Science.gov (United States)

    Churchfield, M.; Wang, Q.; Scholbrock, A.; Herges, T.; Mikkelsen, T.; Sjöholm, M.

    2016-09-01

    We describe the process of using large-eddy simulations of wind turbine wake flow to help design a wake measurement campaign. The main goal of the experiment is to measure wakes and wake deflection that result from intentional yaw misalignment under a variety of atmospheric conditions at the Scaled Wind Farm Technology facility operated by Sandia National Laboratories in Lubbock, Texas. Prior simulation studies have shown that wake deflection may be used for wind-plant control that maximizes plant power output. In this study, simulations are performed to characterize wake deflection and general behavior before the experiment is performed to ensure better upfront planning. Beyond characterizing the expected wake behavior, we also use the large-eddy simulation to test a virtual version of the lidar we plan to use to measure the wake and better understand our lidar scan strategy options. This work is an excellent example of a “simulation-in-the-loop” measurement campaign.

  12. On the measurement of solute concentrations in 2-D flow tank experiments

    OpenAIRE

    M. Konz; P. Ackerer; Meier, E.; P. Huggenberger; E. Zechner; Gechter, D.

    2008-01-01

    International audience; In this study we describe and compare photometric and resistivity measurement methodologies to determine solute concentrations in porous media flow tank experiments. The first method is the photometric method, which directly relates digitally measured intensities of a tracer dye to solute concentrations, without first converting the intensities to optical densities. This enables an effective processing of a large number of images in order to compute concentration time ...

  13. PIENU experiment at TRIUMF: Measurement of π-->eν/π-->μν branching ratio

    Science.gov (United States)

    Sher, A.; Aoki, M.; Blecher, M.; Bryman, D. A.; Comfort, J.; Doornbos, J.; Doria, L.; Gumplinger, P.; Hussein, A.; Igarashi, Y.; Ito, N.; Kettell, S.; Kuno, Y.; Kurchaninov, L.; Littenberg, L.; Malbrunot, C.; Marshal, G.; Muroi, A.; Poutissou, R.; Sandorfi, A.; Yamada, K.

    2009-12-01

    A TRIUMF experiment, PIENU, which aims to measure the branching ratio of pion decays, R = Γ(π→eν+eνγ)/Γ(π→μν+μνγ) to a precision of 0.1% or better is described. Such a measurement provides the best test of electron-muon universality in weak interactions and is sensitive to an effective mass scale of up to 1000 TeV in new physics.

  14. Effect of dextrose, valine, glycine and thiamine on growth rate of Lactobacillus acidophillus incubated at various temperatures

    Directory of Open Access Journals (Sweden)

    A.R Monadi Sefidan

    2014-05-01

    Full Text Available In numerous studies the beneficial impacts of probiotics on human health have been documented. Hence, there is a strong trend for the production of such foods and dairy products in particular, by many of the food processing establishments. In this regard, one of the major perequisites is to recognize the optimum conditions affecting the growth of probiotic organisms. This study aimed to investigate the impact of various concentrations of dextrose, valine, glycine and thiamine as well as different incubation temperatures on growth rate of Lactobacillus acidophillus in steril milk. In order to locate the ideal temperature, L. acidophillus was incubated at 38 °C, 40 °C, 42 °C and 44 °C. Moreover, thiamine (0, 5, 10 and 15 ppm, dextrose (0, 0.4, 0.6, 0.8 and 1%, glycine and valine (0, 30, 60, 90 and 120 ppm was added to steril milk. The acidity of milk-as an indication of bacterial activity-was measured periodically during 0, 1, 2, 3, 4 and 5 h of incubation. In comparison with the other temperatures, the activity of L. acidophillus was found significantly (P < 0.05 higher at 42 °C. According to the results, addition of dextrose, valine, glycine did not accelerate the production of acidic components; however, it seems that these substances could enhance the potency of L. acidophillus to produce gas and proteolytic enzymes.

  15. Pyroelectric properties and conduction mechanism in solution grown glycine sodium nitrate single crystal

    Energy Technology Data Exchange (ETDEWEB)

    Tyagi, Nidhi [Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 7 (India); Sinha, Nidhi [Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 7 (India); Department of Electronics, SGTB Khalsa College, University of Delhi, Delhi 7 (India); Yadav, Harsh [Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 7 (India); Kumar, Binay, E-mail: b3kumar69@yahoo.co.in [Crystal Lab, Department of Physics & Astrophysics, University of Delhi, Delhi 7 (India)

    2015-04-01

    Nonlinear optical “glycine sodium nitrate” transparent single crystals were grown from aqueous solution by the solvent evaporation technique. The ferroelectric transition temperature was determined by dielectric measurement for GSN crystal. Temperature dependent pyroelectric coefficient and figure of merit were measured. The conduction mechanism of GSN crystal has been discussed. The ln σ−E{sup 1/2} characteristic in the high-field region supports dominating the Poole–Frenkel conduction while in the low field region; there are possibility of both Richardson–Schottky and Poole–Frenkel conduction mechanism. The activation energy of GSN crystal was found to be 0.58 eV. A low value of dielectric constant and good value of the figure of merit suggest the GSN crystal more promising for IR sensing applications. Hardness value shows the stability of GSN crystal.

  16. Core density gradient fluctuation measurement by differential interferometry in the helically symmetric experiment stellarator.

    Science.gov (United States)

    Deng, C B; Brower, D L

    2012-10-01

    The interferometer system on the Helically Symmetric eXperiment (HSX) stellarator uses an expanded beam and linear detector array to realize a multichord measurement. Unlike conventional interferometry which determines the plasma phase shift with respect to a reference, directly evaluating the phase between two adjacent chords can be employed to measure the change in plasma phase with impact parameter. This approach provides a measure of the equilibrium density gradient or the density gradient fluctuations and is referred to as differential interferometry. For central chords, measurements are spatially localized due to a geometrical weighting factor and can provide information on core density gradient fluctuations. The measurement requires finite coherence between fluctuations in the two spatially offset chords. This technique is applied on the HSX stellarator to measure both broadband turbulence and coherent modes. Spatial localization is exploited to isolate core turbulence changes associated with change in magnetic configuration or heating location.

  17. Serine, Glycine and One-carbon Metabolism in Colorectal Cancer Cell in Heterogeneous Microenvironment

    Science.gov (United States)

    Lin, Ke-Chih; Austin, Robert; Ducker, Greg; Sturm, James; Sturm, James

    The up-regulation of serine metabolism associated with one-carbon metabolism has been identified to support cellular biosynthesis and redox maintenance of tumors. The consistently over-expressed one-carbon genes have been targeted for potential drug development. To investigate the biological function of specific enzymes, we had genetic engineered HCT116 cell lines, methylenetetrahydrofolate dehydrogenase (MTHFD) and phosphoglycerate dehydrogenase (PHGDH) deleted cell lines, growing in the artificial microhabitats array with serine and glycine gradient across. The impact of depletion of serine and the blocking of biosynthesis pathway will be shown in terms of cell morphology, proliferation rate, and cell motility. The evolution dynamic and migration rate can also be tracked throughout the experiments.

  18. The spatial presence experience scale (SPES): A short self-report measure for diverse media settings

    NARCIS (Netherlands)

    Hartmann, T.; Wirth, W.; Schramm, H.; Klimmt, C.; Vorderer, P.A.; Gysbers, A.; Böcking, S.; Ravaja, N.; Laari, J.; Saari, T.; Gouveia, F.R.; Sacau, A.

    2016-01-01

    The study of spatial presence is currently receiving increased attention in both media psychology and communication research. The present paper introduces the Spatial Presence Experience Scale (SPES), a short eight-item self-report measure. The SPES is derived from a process model of spatial

  19. Measurement of the Compressibility Factor of Gases: A Physical Chemistry Laboratory Experiment

    Science.gov (United States)

    Varberg, Thomas D.; Bendelsmith, Andrew J.; Kuwata, Keith T.

    2011-01-01

    In this article, we describe an experiment for the undergraduate physical chemistry laboratory in which students measure the compressibility factor of two gases, helium and carbon dioxide, as a function of pressure at constant temperature. The experimental apparatus is relatively inexpensive to construct and is described and diagrammed in detail.…

  20. A note on acoustic measurements of turbulence, suspended sediment, and bed forms in mobile bed experiments

    Science.gov (United States)

    One of the challenges of hydraulic experimentation is designing experiments that are complex enough to capture relevant processes while retaining the simplicity necessary for useful, accurate measurements. The intricacy of the interactions between turbulent flows and mobile beds in rivers and stream...

  1. Measuring risk attitudes in a natural experiment: Data from the television game show Lingo

    NARCIS (Netherlands)

    Beetsma, R.M.W.J.; Schotman, P.C.

    2001-01-01

    We use data from a television game show involving elementary lotteries as a natural experiment to measure risk attitudes. Unique features of our data set are the substantial monetary stakes and the large sample size. CRRA and CARA utility specifications perform approximately equally well. We find

  2. Measuring risk attitudes in a natural experiment: Data from the television game show LINGO

    NARCIS (Netherlands)

    Beetsma, R.M.W.J.; Schotman, P.C.

    1998-01-01

    We use data from a television game show, involving elementary lotteries and substantial prize money, as a natural experiment to measure risk attitudes. We find robust evidence of substantial risk aversion. As an extension, we estimate the various models using transformations of the 'true'

  3. Assessing Women's Negative Sanitation Experiences and Concerns: The Development of a Novel Sanitation Insecurity Measure.

    Science.gov (United States)

    Caruso, Bethany A; Clasen, Thomas; Yount, Kathryn M; Cooper, Hannah L F; Hadley, Craig; Haardörfer, Regine

    2017-07-11

    Lack of access to acceptable sanitation facilities can expose individuals, particularly women, to physical, social, and mental health risks. While some of the challenges have been documented, standard metrics are needed to determine the extent to which women have urination- and defecation-related concerns and negative experiences. Such metrics also are needed to assess the effectiveness of interventions to mitigate them. We developed a sanitation insecurity measure to capture the range and frequency of women's sanitation-related concerns and negative experiences. Research was conducted in rural Odisha, India with women across various life course stages to reflect a range of perspectives. This paper documents the mixed data collection methods and the exploratory and confirmatory factor analyses we employed to arrive at a final measure. The final sanitation insecurity measure includes 50 items across seven factors that reflect the physical environment, the social environment, and individual-level constraints. Most factor scores were significantly higher for unmarried women and for women who lacked access to functional latrines, indicating social and environmental influence on experiences. This measure will enable researchers to evaluate how sanitation insecurity affects health and to determine if and how sanitation interventions ameliorate women's concerns and negative experiences associated with sanitation.

  4. Standardized measures of critical thinking. Experience with the California Critical Thinking Tests.

    Science.gov (United States)

    Leppa, C J

    1997-01-01

    Standardized measures of student critical thinking are an attractive option for nursing educators under pressure to demonstrate student higher order thinking skills. One program's experience using the California Critical Thinking Skills Test and the California Critical Thinking Dispositions Inventory illustrates some of the problems of using standardized test and potential solutions.

  5. An Undergraduate Experiment on Nuclear Lifetime Measurement Using the Doppler Effect

    Science.gov (United States)

    Campbell, J. L.; And Others

    1972-01-01

    While designed for a senior undergraduate laboratory, the experiment illustrates the principles involved in the various Doppler techniques currently used in nuclear lifetime studies and demonstrates the versatility of the Ge(Li) detector in applications other than direct energy or intensity measurement. (Author/TS)

  6. Measurement of electron antineutrino oscillation based on 1230 days of operation of the Daya Bay experiment

    CERN Document Server

    An, F P; Band, H R; Bishai, M; Blyth, S; Cao, D; Cao, G F; Cao, J; Cen, W R; Chan, Y L; Chang, J F; Chang, L C; Chang, Y; Chen, H S; Chen, Q Y; Chen, S M; Chen, Y X; Chen, Y; Cheng, J -H; Cheng, J; Cheng, Y P; Cheng, Z K; Cherwinka, J J; Chu, M C; Chukanov, A; Cummings, J P; de Arcos, J; Deng, Z Y; Ding, X F; Ding, Y Y; Diwan, M V; Dolgareva, M; Dove, J; Dwyer, D A; Edwards, W R; Gill, R; Gonchar, M; Gong, G H; Gong, H; Grassi, M; Gu, W Q; Guan, M Y; Guo, L; Guo, X H; Guo, Z; Hackenburg, R W; Han, R; Hans, S; He, M; Heeger, K M; Heng, Y K; Higuera, A; Hor, Y K; Hsiung, Y B; Hu, B Z; Hu, T; Hu, W; Huang, E C; Huang, H X; Huang, X T; Huber, P; Huo, W; Hussain, G; Jaffe, D E; Jaffke, P; Jen, K L; Jetter, S; Ji, X P; Ji, X L; Jiao, J B; Johnson, R A; Jones, D; Joshi, J; Kang, L; Kettell, S H; Kohn, S; Kramer, M; Kwan, K K; Kwok, M W; Kwok, T; Langford, T J; Lau, K; Lebanowski, L; Lee, J; Lee, J H C; Lei, R T; Leitner, R; Leung, J K C; Li, C; Li, D J; Li, F; Li, G S; Li, Q J; Li, S; Li, S C; Li, W D; Li, X N; Li, Y F; Li, Z B; Liang, H; Lin, C J; Lin, G L; Lin, S; Lin, S K; Lin, Y -C; Ling, J J; Link, J M; Littenberg, L; Littlejohn, B R; Liu, D W; Liu, J L; Liu, J C; Loh, C W; Lu, C; Lu, H Q; Lu, J S; Luk, K B; Lv, Z; Ma, Q M; Ma, X Y; Ma, X B; Ma, Y Q; Malyshkin, Y; Caicedo, D A Martinez; McDonald, K T; McKeown, R D; Mitchell, I; Mooney, M; Nakajima, Y; Napolitano, J; Naumov, D; Naumova, E; Ngai, H Y; Ning, Z; Ochoa-Ricoux, J P; Olshevskiy, A; Pan, H -R; Park, J; Patton, S; Pec, V; Peng, J C; Pinsky, L; Pun, C S J; Qi, F Z; Qi, M; Qian, X; Raper, N; Ren, J; Rosero, R; Roskovec, B; Ruan, X C; Steiner, H; Sun, G X; Sun, J L; Tang, W; Taychenachev, D; Treskov, K; Tsang, K V; Tull, C E; Viaux, N; Viren, B; Vorobel, V; Wang, C H; Wang, M; Wang, N Y; Wang, R G; Wang, W; Wang, X; Wang, Y F; Wang, Z; Wang, Z; Wang, Z M; Wei, H Y; Wen, L J; Whisnant, K; White, C G; Whitehead, L; Wise, T; Wong, H L H; Wong, S C F; Worcester, E; Wu, C -H; Wu, Q; Wu, W J; Xia, D M; Xia, J K; Xing, Z Z; Xu, J Y; Xu, J L; Xu, Y; Xue, T; Yang, C G; Yang, H; Yang, L; Yang, M S; Yang, M T; Ye, M; Ye, Z; Yeh, M; Young, B L; Yu, Z Y; Zeng, S; Zhan, L; Zhang, C; Zhang, H H; Zhang, J W; Zhang, Q M; Zhang, X T; Zhang, Y M; Zhang, Y X; Zhang, Y M; Zhang, Z J; Zhang, Z Y; Zhang, Z P; Zhao, J; Zhao, Q W; Zhao, Y B; Zhong, W L; Zhou, L; Zhou, N; Zhuang, H L; Zou, J H

    2016-01-01

    A measurement of electron antineutrino oscillation by the Daya Bay Reactor Neutrino Experiment is described in detail. Six 2.9-GW$_{\\rm th}$ nuclear power reactors of the Daya Bay and Ling Ao nuclear power facilities served as intense sources of $\\overline{\

  7. Temperature measurement during solidification of thin wall ductile cast iron. Part 1: Theory and experiment

    DEFF Research Database (Denmark)

    Pedersen, Karl Martin; Tiedje, Niels Skat

    2008-01-01

    Temperature measurement using thermocouples (TC’s) influence solidification of the casting, especially in thin wall castings. The problems regarding acquisition of detailed cooling curves from thin walled castings is discussed. Experiments were conducted where custom made TC’s were used to acquir...... of castings with different plate thicknesses....

  8. Present status and future of the experiment TGV (measurement of double beta decay of48Ca)

    Science.gov (United States)

    Brudanin, V. B.; Egorov, V. G.; Kovalík, A.; Kovalenko, V. E.; Rukhadze, N. I.; Salamatin, A. V.; Sandukovsky, V. G.; Timkin, V. V.; Vylov, Ts.; Zaparov, Ch.; Briancon, Ch.; Janout, Z.; Koníček, J.; Kubašta, J.; Pospíšil, S.; Štekl, I.; Vorobel, V.

    1998-02-01

    A short description of experiment TGV (double beta decay of48Ca) is given. The measurement started in the Modane underground laboratory in August 1996. The first result of T {1/2/0 ν } ≥ 4.6 × 1020 years [90% CL] after 2545 hours is presented.

  9. Measuring patients' experiences with palliative care: the Consumer Quality Index Palliative Care.

    NARCIS (Netherlands)

    Claessen, S.J.J.; Francke, A.L.; Sixma, H.J.; de Veer, A.J.E.; Deliens, L.

    2012-01-01

    Background: The Consumer Quality Index Palliative Care (CQ-index PC) is a structured questionnaire for measuring the quality of palliative care from the perspective of care users. CQ-indices assess which care aspects need quality improvement by relating answers about actual care experiences to

  10. Measuring patients’ experiences with palliative care: the Consumer Quality Index Palliative Care.

    NARCIS (Netherlands)

    Claessen, S.J.J.; Francke, A.L.; Sixma, H.J.; Veer, A.J.E. de; Deliens, L.

    2012-01-01

    Background: The Consumer Quality Index Palliative Care (CQ-index PC) is a structured questionnaire for measuring the quality of palliative care from the perspective of care users. CQ-indices assess which care aspects need quality improvement by relating answers about actual care experiences to

  11. Measuring Experience With End-of-Life Care: A Systematic Literature Review

    National Research Council Canada - National Science Library

    Lendon, Jessica Penn; Ahluwalia, Sangeeta C; Walling, Anne M; Lorenz, Karl A; Oluwatola, Oluwatobi A; Anhang Price, Rebecca; Quigley, Denise; Teno, Joan M

    2015-01-01

    .... We conducted a systematic review of PubMed, PsycINFO, and PsycTESTS(®) for all English-language articles published after 1990 using instruments to measure adult patient, family, or informal caregiver experiences with end-of-life care...

  12. Using Conductivity Measurements to Determine the Identities and Concentrations of Unknown Acids: An Inquiry Laboratory Experiment

    Science.gov (United States)

    Smith, K. Christopher; Garza, Ariana

    2015-01-01

    This paper describes a student designed experiment using titrations involving conductivity measurements to identify unknown acids as being either HCl or H[subscript 2]SO[subscript 4], and to determine the concentrations of the acids, thereby improving the utility of standard acid-base titrations. Using an inquiry context, students gain experience…

  13. An Undergraduate Experiment for the Measurement of the Speed of Sound in Air: Phenomena and Discussion

    Science.gov (United States)

    Yang, Hujiang; Zhao, Xiaohong; Wang, Xin; Xiao, Jinghua

    2012-01-01

    In this paper, we present and discuss some phenomena in an undergraduate experiment for the measurement of the speed of sound in air. A square wave distorts when connected to a piezoelectric transducer. Moreover, the amplitude of the receiving signal varies with the driving frequency. Comparing with the Gibbs phenomenon, these phenomena can be…

  14. The Quartz-Crystal Microbalance in an Undergraduate Laboratory Experiment II: Measuring Viscosity

    Science.gov (United States)

    Tsionsky, Vladimir

    2007-01-01

    Various water-alcohol and alcohol-alcohol based experiments are used to demonstrate how the quartz-crystal microbalance (QCM) technique is used for measuring the viscosity of a system. The technique is very advantageous, as it is inexpensive and provides digital output.

  15. TOTEM: The experiment to measure the total proton-proton cross section at LHC

    OpenAIRE

    Lami, Stefano

    2006-01-01

    The current large uncertainty on the extrapolation of the proton-proton total cross section at the LHC energy will be resolved by the precise measurement by the TOTEM experiment. Its accurate studies on the basic properties of proton-proton collisions at the maximum accelerator energy could provide a significant contribution to the understanding of cosmic ray physics.

  16. Synthesis of water soluble glycine capped silver nanoparticles and their surface selective interaction

    Energy Technology Data Exchange (ETDEWEB)

    Agasti, Nityananda, E-mail: nnagasti@gmail.com [Department of Chemistry, University of Delhi, Delhi 110007 (India); Singh, Vinay K. [Department of Chemistry, Sri Aurobindo College, University of Delhi, Delhi 110017 (India); Kaushik, N.K. [Department of Chemistry, University of Delhi, Delhi 110007 (India)

    2015-04-15

    Highlights: • Synthesis of water soluble silver nanoparticles at ambient reaction conditions. • Glycine as stabilizing agent for silver nanoparticles. • Surface selective interaction of glycine with silver nanoparticles. • Glycine concentration influences crystalinity and optical property of silver nanoparticles. - Abstract: Synthesis of biocompatible metal nanoparticles has been an area of significant interest because of their wide range of applications. In the present study, we have successfully synthesized water soluble silver nanoparticles assisted by small amino acid glycine. The method is primarily based on reduction of AgNO{sub 3} with NaBH{sub 4} in aqueous solution under atmospheric air in the presence of glycine. UV–vis spectroscopy, transmission electron microscopy (TEM), X–ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TG) and differential thermal analysis (DTA) techniques used for characterization of resulting silver nanoparticles demonstrated that, glycine is an effective capping agent to stabilize silver nanoparticles. Surface selective interaction of glycine on (1 1 1) face of silver nanoparticles has been investigated. The optical property and crystalline behavior of silver nanoparticles were found to be sensitive to concentration of glycine. X–ray diffraction studies ascertained the phase specific interaction of glycine on silver nanoparticles. Silver nanoparticles synthesized were of diameter 60 nm. We thus demonstrated an efficient synthetic method for synthesis of water soluble silver nanoparticles capped by amino acid under mild reaction conditions with excellent reproducibility.

  17. An experiment to measure the one-way velocity of propagation of electromagnetic radiation

    Science.gov (United States)

    Kolen, P.; Torr, D. G.

    1982-01-01

    An experiment involving commercially available instrumentation to measure the velocity of the earth with respect to absolute space is described. The experiment involves the measurement of the one-way propagation velocity of electromagnetic radiation down a high-quality coaxial cable. It is demonstrated that the experiment is both physically meaningful and exceedingly simple in concept and in implementation. It is shown that with currently available commercial equipment one might expect to detect a threshold value for the component of velocity of the earth's motion with respect to absolute space in the equatorial plane of approximately 10 km/s, which greatly exceeds the velocity resolution required to detect the motion of the solar system with respect to the center of the galaxy.

  18. Feasibility Study of an Experiment to Measure the Vacuum Magnetic Birefringence

    CERN Document Server

    Pugnat, P; Finger, Miroslav H; Kral, M; Siemko, A; Zicha, J

    2005-01-01

    The use of a recently decommissioned 15-meters long twin aperture LHC superconducting magnet prototype having a transverse magnetic field B ~ 9.5 T provides the unique opportunity for the construction of a new powerful experiment to measure the Vacuum Magnetic Birefringence (VMB). The values or the limit values of the mass and of the coupling constant to two photons of possible dark matter candidates such as axions are aimed to be deduced from such an experiment. In this article, the technical feasibility study of a new setup to measure the VMB will be presented. It is based on a linear optical resonant cavity housed in the LHC superconducting dipole prototype. The mechanical integrations of the optical components inside the magnet aperture as well as the optical detection principles will be presented. A comparison of the expected performances with respect to the present reference results for this type of experiment will also be given.

  19. The First Pion-Ar Cross-Section Measurement with the LArIAT Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Nutini, Irene [GSSI, Aquila

    2016-01-01

    A complete understanding of neutrinos properties requires a study and a characterization of the interactions of the daughter particles created in a neutrino-nucleus interaction. The Liquid Argon In A Testbeam (LArIAT) experiment is a small-scale liquid argon detector situated in the Fermilab Test Beam Facility. The LArIAT experiment is exposed to a tertiary beam comprised of mostly pions along with a mix of muons, protons, kaons, and electrons. LArIAT's goal is to characterize the response of the LArTPC to known incoming charged particles and measure their interactions in Argon, in order to understand their cross-sections and to help developing and tuning simulations and reconstruction algorithms for LArTPC neutrino experiments. The world's rst measurement of a pion cross-section on an Argon target, made with the LArIAT detector, is presented here.

  20. Measurement of the ambient organic aerosol volatility distribution: application during the Finokalia Aerosol Measurement Experiment (FAME-2008

    Directory of Open Access Journals (Sweden)

    B. H. Lee

    2010-12-01

    Full Text Available A variable residence time thermodenuder (TD was combined with an Aerodyne Aerosol Mass Spectrometer (AMS and a Scanning Mobility Particle Sizer (SMPS to measure the volatility distribution of aged organic aerosol in the Eastern Mediterranean during the Finokalia Aerosol Measurement Experiment in May of 2008 (FAME-2008. A new method for the quantification of the organic aerosol volatility distribution was developed combining measurements of all three instruments together with an aerosol dynamics model.

    Challenges in the interpretation of ambient thermodenuder-AMS measurements include the potential resistances to mass transfer during particle evaporation, the effects of particle size on the evaporated mass fraction, the changes in the AMS collection efficiency and particle density as the particles evaporate partially in the TD, and finally potential losses inside the TD. Our proposed measurement and data analysis method accounts for all of these problems combining the AMS and SMPS measurements.

    The AMS collection efficiency of the aerosol that passed through the TD was found to be approximately 10% lower than the collection efficiency of the aerosol that passed through the bypass. The organic aerosol measured at Finokalia is approximately 2 or more orders of magnitude less volatile than fresh laboratory-generated monoterpene (α-pinene, β-pinene and limonene under low NOx conditions secondary organic aerosol. This low volatility is consistent with its highly oxygenated AMS mass spectrum. The results are found to be highly sensitive to the mass accommodation coefficient of the evaporating species. This analysis is based on the assumption that there were no significant reactions taking place inside the thermodenuder.

  1. Imprint of non-standard interactions on the CP violation measurements at long baseline experiments

    Science.gov (United States)

    Masud, Mehedi; Mehta, Poonam

    2017-10-01

    Neutrino oscillations have been firmly established in the past few decades due to a vast variety of experiments and five of the oscillation parameters (three angles and two mass-squared differences) have been measured to varying degrees of precision. Here the focus is on an important parameter entering the oscillation framework - the leptonic CP-violating phase δ , about which we know very little. We study the consequences of additional CP-conserving and CP-violating parameters in the presence of non-standard neutrino interactions (NSI) on CP-violation studies at the upcoming long baseline experiment, Deep Underground Neutrino Experiment ( DUNE) and compare the capabilities of DUNE with other experiments.

  2. Experiences of mental illness stigma, prejudice and discrimination: a review of measures

    Science.gov (United States)

    2010-01-01

    Background There has been a substantial increase in research on mental illness related stigma over the past 10 years, with many measures in use. This study aims to review current practice in the survey measurement of mental illness stigma, prejudice and discrimination experienced by people who have personal experience of mental illness. We will identify measures used, their characteristics and psychometric properties. Method A narrative literature review of survey measures of mental illness stigma was conducted. The databases Medline, PsychInfo and the British Nursing Index were searched for the period 1990-2009. Results 57 studies were included in the review. 14 survey measures of mental illness stigma were identified. Seven of the located measures addressed aspects of perceived stigma, 10 aspects of experienced stigma and 5 aspects of self-stigma. Of the identified studies, 79% used one of the measures of perceived stigma, 46% one of the measures of experienced stigma and 33% one of the measures of self-stigma. All measures presented some information on psychometric properties. Conclusions The review was structured by considering perceived, experienced and self stigma as separate but related constructs. It provides a resource to aid researchers in selecting the measure of mental illness stigma which is most appropriate to their purpose. PMID:20338040

  3. Experiences of mental illness stigma, prejudice and discrimination: a review of measures

    Directory of Open Access Journals (Sweden)

    Clement Sarah

    2010-03-01

    Full Text Available Abstract Background There has been a substantial increase in research on mental illness related stigma over the past 10 years, with many measures in use. This study aims to review current practice in the survey measurement of mental illness stigma, prejudice and discrimination experienced by people who have personal experience of mental illness. We will identify measures used, their characteristics and psychometric properties. Method A narrative literature review of survey measures of mental illness stigma was conducted. The databases Medline, PsychInfo and the British Nursing Index were searched for the period 1990-2009. Results 57 studies were included in the review. 14 survey measures of mental illness stigma were identified. Seven of the located measures addressed aspects of perceived stigma, 10 aspects of experienced stigma and 5 aspects of self-stigma. Of the identified studies, 79% used one of the measures of perceived stigma, 46% one of the measures of experienced stigma and 33% one of the measures of self-stigma. All measures presented some information on psychometric properties. Conclusions The review was structured by considering perceived, experienced and self stigma as separate but related constructs. It provides a resource to aid researchers in selecting the measure of mental illness stigma which is most appropriate to their purpose.

  4. Experiences of mental illness stigma, prejudice and discrimination: a review of measures.

    Science.gov (United States)

    Brohan, Elaine; Slade, Mike; Clement, Sarah; Thornicroft, Graham

    2010-03-25

    There has been a substantial increase in research on mental illness related stigma over the past 10 years, with many measures in use. This study aims to review current practice in the survey measurement of mental illness stigma, prejudice and discrimination experienced by people who have personal experience of mental illness. We will identify measures used, their characteristics and psychometric properties. A narrative literature review of survey measures of mental illness stigma was conducted. The databases Medline, PsychInfo and the British Nursing Index were searched for the period 1990-2009. 57 studies were included in the review. 14 survey measures of mental illness stigma were identified. Seven of the located measures addressed aspects of perceived stigma, 10 aspects of experienced stigma and 5 aspects of self-stigma. Of the identified studies, 79% used one of the measures of perceived stigma, 46% one of the measures of experienced stigma and 33% one of the measures of self-stigma. All measures presented some information on psychometric properties. The review was structured by considering perceived, experienced and self stigma as separate but related constructs. It provides a resource to aid researchers in selecting the measure of mental illness stigma which is most appropriate to their purpose.

  5. Absolute single photoionization cross-section measurements of Rb 2+ ions: experiment and theory

    Energy Technology Data Exchange (ETDEWEB)

    Macaluso, D. A. [Univ. of Montana, Missoula, MT (United States). Dept. of Physics and Astronomy; Bogolub, K. [Univ. of Montana, Missoula, MT (United States). Dept. of Physics and Astronomy; Johnson, A. [Univ. of Montana, Missoula, MT (United States). Dept. of Physics and Astronomy; Aguilar, A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS); Kilcoyne, A. L. D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS); Bilodeau, R. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS); Univ. of Connecticut, Storrs, CT (United States). Dept. of Physics; Bautista, M. [Western Michigan Univ., Kalamazoo MI (United States). Dept. of Physics; Kerlin, A. B. [Univ. of West Georgia, Carrolton, GA (United States). Dept. of Physics; Sterling, N. C. [Univ. of West Georgia, Carrolton, GA (United States). Dept. of Physics

    2017-05-05

    Absolute single photoionization cross-section measurements of Rb 2+ ions were performed at the Advanced Light Source at Lawrence Berkeley National Laboratory using synchrotron radiation and the photo-ion, merged-beams technique. Measurements were made at a photon energy resolution of 13.5 2.5 meV from 37.31 to 44.08 eV spanning the 2 P ground state and 2 P metastable state ionization thresholds. Multiple autoionizing resonance series arising from each initial state are identified using quantum defect theory. The measurements are compared to Breit-Pauli R-matrix calculations with excellent agreement between theory and experiment.

  6. Measurements of the dielectric properties of simulated comet material as part of the KOSI 10 experiment

    Science.gov (United States)

    Ulamec, S.; Svedhem, H.; Kochan, H.

    1993-01-01

    The dielectric constant epsilon of the snow-mineral used for the comet simulation in the German KOSI 10 experiment was measured in the radio frequency range from 2 to 4 GHz. The traditional microwave bridge method was used, but instead of using a waveguide that contains the sample material small lambda/4 antennas were used as sensors. A change in the dielectric properties indicates a change in density and/or composition, respectively. The method is presented as an analytical tool for measuring such density or composition changes during alteration snow-dust materials. The KOSI (determined from the German: Kometen Simulation) experiments, performed in the Space simulator of the DLR/Institut for Raumsimulation, during the last years revealed many processes that presumably take place on comets. So far, modifications of the internal structure could be identified only during the post-experiment inspection via hardness tests. It was the aim of the KOSI 10 and KOSI 10a experiments to emphasize on a synoptic detection of events like particle emission or crust formation. The composition of the KOSI 10 sample material was an ice-mineral mixture with about 10 percent mineral (olivine) content. An excellent method to investigate the change of the density of the probe material during its exposure to the artificial sun in situ is to do it via the measurement of the dielectric constant. The traditional method to determine epsilon, by using a microwave-bridge to measure the transmission and the reflection factor of the sample material for electromagnetic waves in the radio frequency range, was modified, since the commonly used practice to fill the sample material into a waveguide was not compatible with the need for in situ measurements during the simulation experiment.

  7. Measuring Experience With End-of-Life Care: A Systematic Literature Review.

    Science.gov (United States)

    Lendon, Jessica Penn; Ahluwalia, Sangeeta C; Walling, Anne M; Lorenz, Karl A; Oluwatola, Oluwatobi A; Anhang Price, Rebecca; Quigley, Denise; Teno, Joan M

    2015-05-01

    Increasing interest in end-of-life care has resulted in many tools to measure the quality of care. An important outcome measure of end-of-life care is the family members' or caregivers' experiences of care. To evaluate the instruments currently in use to inform next steps for research and policy in this area. We conducted a systematic review of PubMed, PsycINFO, and PsycTESTS(®) for all English-language articles published after 1990 using instruments to measure adult patient, family, or informal caregiver experiences with end-of-life care. Survey items were abstracted and categorized into content areas identified through an iterative method using three independent reviewers. We also abstracted information from the most frequently used surveys about the identification of proxy respondents for after-death surveys, the timing and method of survey administration, and the health care setting being assessed. We identified 88 articles containing 51 unique surveys with available content. We characterized 14 content areas variably present across the 51 surveys. Information and care planning, provider care, symptom management, and overall experience were the most frequent areas addressed. There was also considerable variation across the surveys in the identification of proxy respondents, the timing of survey administration, and in the health care settings and services being evaluated. This review identified several comprehensive surveys aimed at measuring the experiences of end-of-life care, covering a variety of content areas and practical issues for survey administration. Future work should focus on standardizing surveys and administration methods so that experiences of care can be reliably measured and compared across care settings. Published by Elsevier Inc.

  8. Organizational and market influences on physician performance on patient experience measures.

    Science.gov (United States)

    Rodriguez, Hector P; von Glahn, Ted; Rogers, William H; Safran, Dana Gelb

    2009-06-01

    To examine the extent to which medical group and market factors are related to individual primary care physician (PCP) performance on patient experience measures. This study employs Clinician and Group CAHPS survey data (n=105,663) from 2,099 adult PCPs belonging to 34 diverse medical groups across California. Medical group directors were interviewed to assess the magnitude and nature of financial incentives directed at individual physicians and the adoption of patient experience improvement strategies. Primary care services area (PCSA) data were used to characterize the market environment of physician practices. We used multilevel models to estimate the relationship between medical group and market factors and physician performance on each Clinician and Group CAHPS measure. Models statistically controlled for respondent characteristics and accounted for the clustering of respondents within physicians, physicians within medical groups, and medical groups within PCSAs using random effects. Compared with physicians belonging to independent practice associations, physicians belonging to integrated medical groups had better performance on the communication ( p=.007) and care coordination ( p=.03) measures. Physicians belonging to medical groups with greater numbers of PCPs had better performance on all measures. The use of patient experience improvement strategies was not associated with performance. Greater emphasis on productivity and efficiency criteria in individual physician financial incentive formulae was associated with worse access to care ( p=.04). Physicians located in PCSAs with higher area-level deprivation had worse performance on the access to care ( p=.04) and care coordination ( pintegrated medical groups and groups with greater numbers of PCPs performed better on several patient experience measures, suggesting that organized care processes adopted by these groups may enhance patients' experiences. Physicians practicing in markets with high

  9. Measurement of 3-axis magnetic fields induced by current wires using a smartphone in magnetostatics experiments

    Science.gov (United States)

    Setiawan, B.; Septianto, R. D.; Suhendra, D.; Iskandar, F.

    2017-11-01

    This paper describes the use of an inexpensive smartphone’s magnetic sensor to measure magnetic field components (B x , B y and B z ) induced by current wires in magnetostatic experiments. The variable parameters used to measure the magnetic sensor’s capabilities were: the geometrical shapes of the wire, current flow, and the distance between wire and observation point. The experimental results are in good agreement with the results obtained from calculations using an analytical and numerical approach. In addition, the 2D vectors and magnitude of the magnetic field have been successfully illustrated. This study confirmed that the inexpensive smartphone’s magnetic sensor had a good ability to accurately measure the components of a magnetic field in a magnetostatic experiment, which is especially suitable for undergraduate students.

  10. Nitrogen Fertilizer and Straw Applications Affect Uptake of 13C,15N-Glycine by Soil Microorganisms in Wheat Growth Stages.

    Science.gov (United States)

    Yang, Lijie; Zhang, Lili; Yu, Chunxiao; Li, Dongpo; Gong, Ping; Xue, Yan; Song, Yuchao; Cui, Yalan; Doane, Timothy A; Wu, Zhijie

    2017-01-01

    This study investigated the influence of nitrogen (N) fertilizer and straw on intact amino acid N uptake by soil microorganisms and the relationship between amino acid turnover and soil properties during the wheat growing season. A wheat pot experiment was carried out with three treatments: control (CK), N fertilizer (NF) and N fertilizer plus rice straw (NS). We used stable isotope compound-specific analysis to determine the uptake of 13C,15N-glycine by soil microorganisms. In the NF treatment, microbial 13C,15N-glycine uptake was lower compared with CK, suggesting that inorganic N was the preferred N source for soil microorganisms. However, The application of straw with N fertilizer (in NS treatment) increased microbial 13C,15N-glycine uptake even with the same amount of N fertilizer application. In this treatment, enzyme activities, soil microbial biomass C and microbial biomass N increased simultaneously because more C was available. Soil mineral N and plant N contents all decreased substantially. The increased uptake of intact 13C,15N-glycine in the NS treatment can be attributed to direct assimilation by soil microorganisms to satisfy the demand for N when inorganic N was consumed.

  11. Measurement of the W-boson mass in the ATLAS experiment at the LHC

    CERN Document Server

    Lin, Tai-Hua; The ATLAS collaboration

    2017-01-01

    The measurement of the W -boson mass in proton–proton collisions in the ATLAS experiment at the Large Hadron Collider (LHC) provides a consistency test of the Standard Model and a probe of Beyond the Standard Model physics. A first measurement of the W-boson mass at the LHC is presented in this proceeding. The measurement of the W -boson mass is performed with leptonic decays of the W -boson. The data is recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC. The combined result of the W-boson mass is measured to be 80369.5 $\\pm$ 18.5 MeV where the total uncertainty includes the statistical, experimental systematic, and physics-modelling systematic uncertainty. The mass difference between positive charged W -bosons and negative charged W -bosons is measured to be −29 $\\pm$ 28 MeV.

  12. Accuracy optimization of high-speed AFM measurements using Design of Experiments

    DEFF Research Database (Denmark)

    Tosello, Guido; Marinello, F.; Hansen, Hans Nørgaard

    2010-01-01

    Atomic Force Microscopy (AFM) is being increasingly employed in industrial micro/nano manufacturing applications and integrated into production lines. In order to achieve reliable process and product control at high measuring speed, instrument optimization is needed. Quantitative AFM measurement......, the estimated dimensions of measured features. The definition of scan settings is based on a comprehensive optimization that targets maximization of information from collected data and minimization of measurement uncertainty and scan time. The Design of Experiments (DOE) technique is proposed and applied...... to perform the optimization of AFM measurements on calibrated one-dimensional silicon grating featuring a triangular periodical profile (slopes of 54.7 degrees, period of 3 μm)....

  13. Metronome LKM: An open source virtual keyboard driver to measure experiment software latencies.

    Science.gov (United States)

    Garaizar, Pablo; Vadillo, Miguel A

    2017-10-01

    Experiment software is often used to measure reaction times gathered with keyboards or other input devices. In previous studies, the accuracy and precision of time stamps has been assessed through several means: (a) generating accurate square wave signals from an external device connected to the parallel port of the computer running the experiment software, (b) triggering the typematic repeat feature of some keyboards to get an evenly separated series of keypress events, or (c) using a solenoid handled by a microcontroller to press the input device (keyboard, mouse button, touch screen) that will be used in the experimental setup. Despite the advantages of these approaches in some contexts, none of them can isolate the measurement error caused by the experiment software itself. Metronome LKM provides a virtual keyboard to assess an experiment's software. Using this open source driver, researchers can generate keypress events using high-resolution timers and compare the time stamps collected by the experiment software with those gathered by Metronome LKM (with nanosecond resolution). Our software is highly configurable (in terms of keys pressed, intervals, SysRq activation) and runs on 2.6-4.8 Linux kernels.

  14. Subjective Narcosis Assessment Scale: measuring the subjective experience of nitrogen narcosis.

    Science.gov (United States)

    van Wijk, Charles H; Meintjes, W A J

    2014-01-01

    The interaction of subjective experiences and objective measures of neuropsychological performance during hyperbaric exposure has received less attention in the literature, in part due to the shortage of available and appropriately standardized measures. This study aimed to describe the psychometric properties of a modified version of the Subjective High Assessment Scale when used in the hyperbaric context, by exploring internal reliability, factor structure, associations with psychological variables and simple cognitive delayed recall, and the effect of task focus on the recall of subjective experience. Seventy qualified divers completed dry hyperbaric chamber dives to 607.95 kPa, and completed ratings of their subjective experiences. Some also completed a delayed recall task and psychological measures prior to their dives. The scale displayed good internal consistency, with four meaningful factors emerging. It showed some significant but small associations with trait anxiety and transient mood states, and a small to moderate correlation with recall performance. There was no significant effect of task focus on self-report of subjective experiences. The modified scale, renamed the Subjective Narcosis Assessment Scale here, has useful psychometric properties, and promising potential for future use.

  15. Analysis of oligonucleotide array experiments with repeated measures using mixed models

    Directory of Open Access Journals (Sweden)

    Getchell Thomas V

    2004-12-01

    Full Text Available Abstract Background Two or more factor mixed factorial experiments are becoming increasingly common in microarray data analysis. In this case study, the two factors are presence (Patients with Alzheimer's disease or absence (Control of the disease, and brain regions including olfactory bulb (OB or cerebellum (CER. In the design considered in this manuscript, OB and CER are repeated measurements from the same subject and, hence, are correlated. It is critical to identify sources of variability in the analysis of oligonucleotide array experiments with repeated measures and correlations among data points have to be considered. In addition, multiple testing problems are more complicated in experiments with multi-level treatments or treatment combinations. Results In this study we adopted a linear mixed model to analyze oligonucleotide array experiments with repeated measures. We first construct a generalized F test to select differentially expressed genes. The Benjamini and Hochberg (BH procedure of controlling false discovery rate (FDR at 5% was applied to the P values of the generalized F test. For those genes with significant generalized F test, we then categorize them based on whether the interaction terms were significant or not at the α-level (αnew = 0.0033 determined by the FDR procedure. Since simple effects may be examined for the genes with significant interaction effect, we adopt the protected Fisher's least significant difference test (LSD procedure at the level of αnew to control the family-wise error rate (FWER for each gene examined. Conclusions A linear mixed model is appropriate for analysis of oligonucleotide array experiments with repeated measures. We constructed a generalized F test to select differentially expressed genes, and then applied a specific sequence of tests to identify factorial effects. This sequence of tests applied was designed to control for gene based FWER.

  16. The road to patient experience of care measurement: lessons from the United States.

    Science.gov (United States)

    Zimlichman, Eyal; Rozenblum, Ronen; Millenson, Michael L

    2013-09-17

    Patient-centered care has become an increasing priority in the United States and plays a prominent role in recent healthcare reforms. One way the country has managed to advance patient-centered care is through establishment of a family of national patient experience surveys (the Consumer Assessment of Healthcare Providers and Systems Plans (CAHPS). CAHPS is publicly reported for several types of providers and was recently tied to hospital reimbursement. This is part of a trend over the last two decades that has shifted provider-patient relationships from a traditional paternal approach to customer service and then to clinical partnership. The health care system in Israel, however, is still struggling to overcome barriers to change in this area. While community based biannual patient experience surveys are conducted by the Myers-JDC-Brookdale Institute, there is no comprehensive national approach to measuring the patient experience across a broad range of settings. Only recently did the Israeli Ministry of Health take its first steps to include patient experience as a dimension of health care quality.In its current position, Israel should learn from the U.S. experience with policies promoting patient-centered care, and specifically the impact on clinical services of measuring the patient experience. Looking at what has happened in the United States, we suggest three main lessons. First, there is a need for a set of national patient experience surveys that would be publicly reported and eventually tied to provider reimbursement. Secondly, the national survey tools should be customized to the unique characteristics of Israeli society and draw from recent research on patient-centeredness to include new and important domains such as patient activation and shared decision-making. Finally, newer technological approaches should be explored with the aim of increasing response rates and the timeliness and usefulness of the surveys.

  17. Experiments to Evaluate and Implement Passive Tracer Gas Methods to Measure Ventilation Rates in Homes

    Energy Technology Data Exchange (ETDEWEB)

    Lunden, Melissa [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Faulkner, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Heredia, Elizabeth [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cohn, Sebastian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dickerhoff, Darryl [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Noris, Federico [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Logue, Jennifer [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hotchi, Toshifumi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singer, Brett [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sherman, Max H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-10-01

    This report documents experiments performed in three homes to assess the methodology used to determine air exchange rates using passive tracer techniques. The experiments used four different tracer gases emitted simultaneously but implemented with different spatial coverage in the home. Two different tracer gas sampling methods were used. The results characterize the factors of the execution and analysis of the passive tracer technique that affect the uncertainty in the calculated air exchange rates. These factors include uncertainties in tracer gas emission rates, differences in measured concentrations for different tracer gases, temporal and spatial variability of the concentrations, the comparison between different gas sampling methods, and the effect of different ventilation conditions.

  18. Undergraduate Laboratory Experiment: Measuring Matter Antimatter Asymmetries at the Large Hadron Collider

    CERN Document Server

    Parkes, Chris; Gutierrez, J

    2015-01-01

    This document is the student manual for a third year undergraduate laboratory experiment at the University of Manchester. This project aims to measure a fundamental difference between the behaviour of matter and antimatter through the analysis of data collected by the LHCb experiment at the Large Hadron Collider. The three-body dmecays $B^\\pm \\rightarrow h^\\pm h^+ h^-$, where $h^\\pm$ is a $\\pi^\\pm$ or $K^\\pm$ are studied. The inclusive matter antimatter asymmetry is calculated, and larger asymmetries are searched for in localized regions of the phase-space.

  19. Process measures or patient reported experience measures (PREMs) for comparing performance across providers? A study of measures related to access and continuity in Swedish primary care.

    Science.gov (United States)

    Glenngård, Anna H; Anell, Anders

    2017-09-15

    Aim To study (a) the covariation between patient reported experience measures (PREMs) and registered process measures of access and continuity when ranking providers in a primary care setting, and (b) whether registered process measures or PREMs provided more or less information about potential linkages between levels of access and continuity and explaining variables. Access and continuity are important objectives in primary care. They can be measured through registered process measures or PREMs. These measures do not necessarily converge in terms of outcomes. Patient views are affected by factors not necessarily reflecting quality of services. Results from surveys are often uncertain due to low response rates, particularly in vulnerable groups. The quality of process measures, on the other hand, may be influenced by registration practices and are often more easy to manipulate. With increased transparency and use of quality measures for management and governance purposes, knowledge about the pros and cons of using different measures to assess the performance across providers are important. Four regression models were developed with registered process measures and PREMs of access and continuity as dependent variables. Independent variables were characteristics of providers as well as geographical location and degree of competition facing providers. Data were taken from two large Swedish county councils. Findings Although ranking of providers is sensitive to the measure used, the results suggest that providers performing well with respect to one measure also tended to perform well with respect to the other. As process measures are easier and quicker to collect they may be looked upon as the preferred option. PREMs were better than process measures when exploring factors that contributed to variation in performance across providers in our study; however, if the purpose of comparison is continuous learning and development of services, a combination of PREMs and

  20. Understanding excess skin in postbariatric patients: objective measurements and subjective experiences.

    Science.gov (United States)

    Biörserud, Christina; Olbers, Torsten; Staalesen, Trude; Elander, Anna; Olsén, Monika Fagevik

    2016-08-01

    Excess skin is a well-known side effect of massive weight loss after bariatric surgery. However, there is a lack of longitudinal follow-ups. The primary aims of this study were to investigate the development and amount of excess skin after laparoscopic Roux-en-Y gastric bypass and to relate objective results to subjective experiences. University hospital. From 2009 to 2012, 200 patients were included and assessed with respect to excess skin before and 18 months after bariatric surgery. Patients were measured according to a standardized protocol and completed a questionnaire regarding their subjective experience of excess skin. A follow-up visit was completed in 149 patients (78%). All ptosis measurements decreased after weight reduction except for ptosis on the thighs. When comparing objective measurements with patients' subjective experience and discomfort from excess skin, we found little or low correlation in most body parts (rs .03-.67). The prediction analysis indicated that, for every centimeter of ptosis on the abdomen preoperatively, there was a 2-fold greater probability of having a postoperative ptosis on the abdomen of>3 cm (OR = 2.32, 1.76-3.07). The objective measurement of excess skin provides unique information in postbariatric patients' body habitus. Although the measured excess skin decreased compared with preoperative measurements, patients seem to become more aware of and disturbed and discomforted by it after the weight loss. Importantly, the objectively assessed measurements of excess skin correlated fairly with the perceived discomfort. Copyright © 2016 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  1. A Platform for X-Ray Thomson Scattering Measurements of Radiation Hydrodynamics Experiments on the NIF

    Science.gov (United States)

    Lefevre, Heath; Ma, Kevin; Belancourt, Patrick; MacDonald, Michael; Doeppner, Tilo; Keiter, Paul; Kuranz, Carolyn

    2017-10-01

    A recent experiment on the National Ignition Facility (NIF) radiographed the evolution of the Rayleigh-Taylor (RT) instability under high and low drive cases. This experiment showed that under a high drive the growth rate of the RT instability is reduced relative to the low drive case. The high drive launches a radiative shock, increases the temperature of the post-shock region, and ablates the spikes, which reduces the RT growth rate. The plasma parameters must be measured to validate this claim. We present a target design for making X-Ray Thomson Scattering (XRTS) measurements on radiation hydrodynamics experiments on NIF to measure the electron temperature of the shocked region in the above cases. Specifically, we show that a previously fielded NIF radiation hydrodynamics platform can be modified to allow sufficient signal and temperature resolution for XRTS measurements. This work is funded by the NNSA-DS and SC-OFES Joint Program in High-Energy-Density Laboratory Plasmas, Grant Number DE-NA0002956 and the National Science Foundation through the Basic Plasma Science and Engineering program.

  2. The AEgIS experiment at CERN for the measurement of antihydrogen gravity acceleration

    Science.gov (United States)

    Scampoli, Paola; Storey, James

    2014-05-01

    The Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy (AEgIS) experiment is conducted by an international collaboration based at CERN whose aim is to perform the first direct measurement of the gravitational acceleration of antihydrogen in the local field of the Earth, with Δg/g = 1% precision as a first achievement. The idea is to produce cold (100 mK) antihydrogen (\\bar H) through a pulsed charge exchange reaction by overlapping clouds of antiprotons, from the Antiproton Decelerator (AD) and positronium atoms inside a Penning trap. The antihydrogen has to be produced in an excited Rydberg state to be subsequently accelerated to form a beam. The deflection of the antihydrogen beam can then be measured by using a moiré deflectometer coupled to a position sensitive detector to register the impact point of the anti-atoms through the vertex reconstruction of their annihilation products. After being approved in late 2008, AEgIS started taking data in a commissioning phase in 2012. This paper presents an outline of the experiment with a brief overview of its physics motivation and of the state-of-the-art of the g measurement on antimatter. Particular attention is given to the current status of the emulsion-based position detector needed to measure the \\bar H sag in AEgIS.

  3. Neutrino velocity measurement with the OPERA experiment in the CNGS beam

    CERN Document Server

    Brunetti, Giulia; Sioli, Maximiliano

    The thesis concerns the measurement of the neutrino velocity with the OPERA experiment in the CNGS beam. There are different theoretical models that allow for Lorentz violating effects which can be investigated with measurements on terrestrial neutrino beams. The MINOS experiment published in 2007 a measure on the muon neutrinos over a distance of 730 km finding a deviation with respect to the expected time of flight of 126 ns with a statistical error of 32 ns and a systematic error of 64 ns. The OPERA experiment observes as well muon neutrinos 730 km away from the source, with a sensitivity significantly better than MINOS thanks to the higher number of interactions in the detector due to the higher energy beam and the much more sophisticated timing system explicitly upgraded in view of the neutrino velocity measurement. This system is composed by atomic cesium clocks and GPS receivers operating in "common view mode". Thanks to this system a time-transfer between the two sites with a precision at the level of...

  4. Relations among questionnaire and experience sampling measures of inner speech: a smartphone app study.

    Science.gov (United States)

    Alderson-Day, Ben; Fernyhough, Charles

    2015-01-01

    Inner speech is often reported to be a common and central part of inner experience, but its true prevalence is unclear. Many questionnaire-based measures appear to lack convergent validity and it has been claimed that they overestimate inner speech in comparison to experience sampling methods (which involve collecting data at random timepoints). The present study compared self-reporting of inner speech collected via a general questionnaire and experience sampling, using data from a custom-made smartphone app (Inner Life). Fifty-one university students completed a generalized self-report measure of inner speech (the Varieties of Inner Speech Questionnaire, VISQ) and responded to at least seven random alerts to report on incidences of inner speech over a 2-week period. Correlations and pairwise comparisons were used to compare generalized endorsements and randomly sampled scores for each VISQ subscale. Significant correlations were observed between general and randomly sampled measures for only two of the four VISQ subscales, and endorsements of inner speech with evaluative or motivational characteristics did not correlate at all across different measures. Endorsement of inner speech items was significantly lower for random sampling compared to generalized self-report, for all VISQ subscales. Exploratory analysis indicated that specific inner speech characteristics were also related to anxiety and future-oriented thinking.

  5. The Work Experience Measurement Scale (WEMS): a useful tool in workplace health promotion.

    Science.gov (United States)

    Nilsson, Petra; Andersson, H Ingemar; Ejlertsson, Göran

    2013-01-01

    To present validity data for the Work Experience Measurement Scale (WEMS), an instrument measuring multifaceted work experience from a salutogenic health resource perspective as a contrast to the more common pathogenic risk perspective, by exploring WEMS relationship to established measurements that are positively related to health and work. A salutogenic perspective focuses on finding conditions and resources in life, for example at work, that can enhance the individual's health and strength, instead of those causing illness and weakness. This study was carried out in 2009 at a Swedish hospital with a web-based survey (WEMS) to 770 employees. Different occupational groups at the hospital participated. Additional questionnaires used at the same time were the Utrecht Work Engagement Scale (UWES-9), the Salutogenic Health Indicator Scale (SHIS), the General Self-Efficacy scale (GSE), and three questions about self-rated health, general well-being, and quality of life. Cronbach's Alpha of WEMS sub-indices were in the interval of 0.85-0.96. Convergent validity and discriminant validity of WEMS and its sub-indices were shown to be satisfying by correlations. In addition, WEMS demonstrated the ability to discriminate between groups. WEMS sub-indices discriminated even better between groups than the total index. The WEMS proved to be a workplace health promotion questionnaire that was able to measure experiences of work from a salutogenic perspective. The WEMS has a potential of being a useful tool in workplace health promotion to enhance positive human capabilities and resources to improve work performance.

  6. Relations among questionnaire and experience sampling measures of inner speech: A smartphone app study

    Directory of Open Access Journals (Sweden)

    Ben eAlderson-Day

    2015-04-01

    Full Text Available Inner speech is often reported to be a common and central part of inner experience, but its true prevalence is unclear. Many questionnaire-based measures appear to lack convergent validity and it has been claimed that they overestimate inner speech in comparison to experience sampling methods (which involve collecting data at random timepoints. The present study compared self-reporting of inner speech collected via a general questionnaire and experience sampling, using data from a custom-made smartphone app (Inner Life. Fifty-one university students completed a generalized self-report measure of inner speech (the Varieties of Inner Speech Questionnaire, or VISQ and responded to at least 7 random alerts to report on incidences of inner speech over a 2-week period. Correlations and pairwise comparisons were used to compare generalized endorsements and randomly-sampled scores for each VISQ subscale. Significant correlations were observed between general and randomly sampled measures for only 2 of the 4 VISQ subscales, and endorsements of inner speech with evaluative or motivational characteristics did not correlate at all across different measures. Endorsement of inner speech items was significantly lower for random sampling compared to generalized self-report, for all VISQ subscales. Exploratory analysis indicated that specific inner speech characteristics were also related to anxiety and future-oriented thinking.

  7. Alpha2 subunit specificity of cyclothiazide inhibition on glycine receptors.

    Science.gov (United States)

    Zhang, Xiao-Bing; Sun, Guang-Chun; Liu, Lu-Ying; Yu, Fang; Xu, Tian-Le

    2008-04-01

    In the mammalian cortex, alpha2 subunit-containing glycine receptors (GlyRs) mediate tonic inhibition, but the precise functional role of this type of GlyRs is difficult to establish because of the lack of subtype-selective antagonist. In this study, we found that cyclothiazide (CTZ), an epileptogenic agent, potently inhibited GlyR-mediated current (I(Gly)) in cultured rat hippocampal neurons. The inhibition was glycine concentration-dependent, suggesting a competitive mechanism. Note that GlyRs containing the alpha2 but not alpha1 or alpha3 subunits, when being heterologously expressed in human embryonic kidney 293T cells, were inhibited by CTZ, indicating subunit specificity of CTZ action. In addition, the degree of CTZ inhibition on I(Gly) in rat spinal neurons declined with time in culture, in parallel with a decline of alpha2 subunit expression, which is known to occur during spinal cord development. Furthermore, site-directed mutagenesis indicates that a single-amino acid threonine at position 59 near the N terminus of the alpha2 subunit confers the specificity of CTZ action. Thus, CTZ is a potent and selective inhibitor of alpha2-GlyRs, and threonine at position 59 plays a critical role in the susceptibility of GlyR to CTZ inhibition.

  8. Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons.

    Directory of Open Access Journals (Sweden)

    Loïs S Miraucourt

    Full Text Available Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy. During tactile allodynia, activation of the sensory fibers which normally detect touch elicits pain. Here we provide a new behavioral investigation into the dynamic component of tactile allodynia that developed in rats after segmental removal of glycine inhibition. Using in vivo electrophysiological recordings, we show that in this condition innocuous mechanical stimuli could activate superficial dorsal horn nociceptive specific neurons. These neurons do not normally respond to touch. We anatomically show that the activation was mediated through a local circuit involving neurons expressing the gamma isoform of protein kinase C (PKCgamma. Selective inhibition of PKCgamma as well as selective blockade of glutamate NMDA receptors in the superficial dorsal horn prevented both activation of the circuit and allodynia. Thus, our data demonstrates that a normally inactive circuit in the dorsal horn can be recruited to convert touch into pain. It also provides evidence that glycine inhibitory dysfunction gates tactile input to nociceptive specific neurons through PKCgamma-dependent activation of a local, excitatory, NMDA receptor-dependent, circuit. As a consequence of these findings, we suggest that pharmacological inhibition of PKCgamma might provide a new tool for alleviating allodynia in the clinical setting.

  9. Oral administration of glycine in the prevention of restenosis after coronary angioplasty. A double blind placebo controlled randomized feasibility trial evaluating safety and efficacy of glycine in the prevention of restenosis after angioplasty

    NARCIS (Netherlands)

    Khan, Muchtiar; Ron van der Wieken, L.; Riezebos, Robert K.; Tijssen, Jan G. P.; Kiemeneij, Ferdinand; Slagboom, Ton; Laarman, Gert-Jan

    2006-01-01

    OBJECTIVES: Evaluation of safety, feasibility, and efficacy of oral administered glycine in prevention of angiographic restenosis six months after percutaneous coronary intervention (PCI). BACKGROUND: The amino acid glycine modulates immunological response and enhances the production of endothelial

  10. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways

    Directory of Open Access Journals (Sweden)

    Benton Valery M

    2009-05-01

    Full Text Available Abstract Background N-arachidonoyl glycine (NAGly is an endogenous signaling lipid with a wide variety of biological activity whose biosynthesis is poorly understood. Two primary biosynthetic pathways have been proposed. One suggests that NAGly is formed via an enzymatically regulated conjugation of arachidonic acid (AA and glycine. The other suggests that NAGly is an oxidative metabolite of the endogenous cannabinoid, anandamide (AEA, through an alcohol dehydrogenase. Here using both in vitro and in vivo assays measuring metabolites with LC/MS/MS we test the hypothesis that both pathways are present in mammalian cells. Results The metabolic products of deuterium-labeled AEA, D4AEA (deuterium on ethanolamine, indicated that NAGly is formed by the oxidation of the ethanolamine creating a D2NAGly product in both RAW 264.7 and C6 glioma cells. Significantly, D4AEA produced a D0NAGly product only in C6 glioma cells suggesting that the hydrolysis of AEA yielded AA that was used preferentially in a conjugation reaction. Addition of the fatty acid amide (FAAH inhibitor URB 597 blocked the production of D0NAGly in these cells. Incubation with D8AA in C6 glioma cells likewise produced D8NAGly; however, with significantly less efficacy leading to the hypothesis that FAAH-initiated AEA-released AA conjugation with glycine predominates in these cells. Furthermore, the levels of AEA in the brain were significantly increased, whereas those of NAGly were significantly decreased after systemic injection of URB 597 in rats and in FAAH KO mice further supporting a role for FAAH in endogenous NAGly biosynthesis. Incubations of NAGly and recombinant FAAH demonstrated that NAGly is a significantly less efficacious substrate for FAAH with only ~50% hydrolysis at 30 minutes compared to 100% hydrolysis of AEA. Co-incubations of AEA and glycine with recombinant FAAH did not, however, produce NAGly. Conclusion These data support the hypothesis that the signaling lipid

  11. Accurate measurement of JHHin overlapped signals by a TOCSY-edited SERF Experiment.

    Science.gov (United States)

    Fredi, André; Nolis, Pau; Parella, Teodor

    2017-06-01

    Selective refocusing (GSERF or the recent PSYCHEDELIC) experiments were originally designed to determine all proton-proton coupling constants (J HH ) for a selected proton resonance. They work for isolated signals on which selective excitation can be successfully applied but, as it happens in other selective experiments, fail for overlapped signals. To circumvent this limitation, a doubly-selective TOCSY-GSERF scheme is presented for the measurement of J HH in protons resonating in crowded regions. This new experiment takes advantage of the editing features of an initial TOCSY transfer to uncover hidden resonances that become accessible to perform the subsequent frequency-selective refocusing. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  12. Validation of the Child HCAHPS survey to measure pediatric inpatient experience of care in Flanders.

    Science.gov (United States)

    Bruyneel, Luk; Coeckelberghs, Ellen; Buyse, Gunnar; Casteels, Kristina; Lommers, Barbara; Vandersmissen, Jo; Van Eldere, Johan; Van Geet, Chris; Vanhaecht, Kris

    2017-07-01

    The recently developed Child HCAHPS provides a standard to measure US hospitals' performance on pediatric inpatient experiences of care. We field-tested Child HCAHPS in Belgium to instigate international comparison. In the development stage, forward/backward translation was conducted and patients assessed content validity index as excellent. The draft Flemish Child HCAHPS included 63 items: 38 items for five topics hypothesized to be similar to those proposed in the US (communication with parent, communication with child, attention to safety and comfort, hospital environment, and global rating), 10 screeners, a 14-item demographic and descriptive section, and one open-ended item. A 6-week pilot test was subsequently performed in three pediatric wards (general ward, hematology and oncology ward, infant and toddler ward) at a JCI-accredited university hospital. An overall response rate of 90.99% (303/333) was achieved and was consistent across wards. Confirmatory factor analysis largely confirmed the configuration of the proposed composites. Composite and single-item measures related well to patients' global rating of the hospital. Interpretation of different patient experiences across types of wards merits further investigation. Child HCAHPS provides an opportunity for systematic and cross-national assessment of pediatric inpatient experiences. Sharing and implementing international best practices are the next logical step. What is Known: • Patient experience surveys are increasingly used to reflect on the quality, safety, and centeredness of patient care. • While adult inpatient experience surveys are routinely used across countries around the world, the measurement of pediatric inpatient experiences is a young field of research that is essential to reflect on family-centered care. What is New: • We demonstrate that the US-developed Child HCAHPS provides an opportunity for international benchmarking of pediatric inpatient experiences with care through parents

  13. The high precision measurement of the 144Ce activity in the SOX experiment

    Science.gov (United States)

    Di Noto, L.; Agostini, M.; Althenmüller, K.; Appel, S.; Bellini, G.; Benziger, J.; Berton, N.; Bick, D.; Bonfini, G.; Bravo—Berguño, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Cereseto, R.; Chepurnov, A.; Choi, K.; Cribier, M.; DAngelo, D.; Davini, S.; Derbin, A.; Drachnev, I.; Durero, M.; Etenko, A.; Farinon, S.; Fischer, V.; Fomenko, K.; Franco, D.; Gabriele, F.; Gaffiot, J.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Göeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Houdy, Th; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jonquères, N.; Jedrzejczak, K.; Kaiser, M.; Kobychev, V.; Korablev, D.; Korga, G.; Kornoukhov, V.; Kryn, D.; Lachenmaier, T.; Lasserre, T.; Laubenstein, M.; Lehnert, T.; Link, J.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Maricic, J.; Mention, G.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Musenich, R.; Neumair, B.; Oberauer, L.; Obolensky, M.; Ortica, F.; Pallavicini, M.; Papp, L.; Perasso, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Roncin, R.; Rossi, C.; Rossi, N.; Schönert, S.; Scola, L.; Semenov, D.; Simgen, H.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Veyssière, C.; Vivier, M.; Unzhakov, E.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

    2016-02-01

    In order to perform a resolutive measurement to clarify the neutrino anomalies and to observe possible short distance neutrino oscillations, the SOX (Short distance neutrino Oscillations with BoreXino) experiment is under construction. In the first phase, a 100 kCi 144Ce-144Pr antineutrino source will be placed under the Borexino detector at the Laboratori Nazionali del Gran Sasso (LNGS), in center of Italy, and the rate measurement of the antineutrino events, observed by the very low radioactive background Borexino detector, will be compared with the high precision (< 1%) activity measurement performed by two calorimeters. The source will be embedded in a 19 mm thick tungsten alloy shield and both the calorimeters have been conceived for measuring the thermal heat absorbed by a water flow. In this report the design of the calorimeters will be described in detail and very preliminary results will be also shown.

  14. An indirect measurement of the width of the w boson at the D0 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Telford, Paul [Univ. of Manchester (United Kingdom)

    2006-01-01

    This thesis presents an indirect measurement of the width of the W boson using data collected at the D0 experiment, a multipurpose particle detector utilizing the Fermilab Tevatron. The W width was determined from the ratio of W → μv to Z → μ+μ- cross sections to be ΓW = 2168 ± 22(stat) ± 62(syst)$+24\\atop{-16}$(pdf) ±4(other) MeV, in good agreement with the Standard Model prediction and other experimental measurements. In addition there is a description of how work made towards this measurement has been used to improve the parameterized detector simulation, a vital tool in the obtention of physics results from signals observed in the detector, and in estimating the uncertainty due to choice of PDF, which is of interest for all measurements made at hadron colliders.

  15. Measuring the Change in Water Table with Gravity Methods - a Controlled Experiment

    DEFF Research Database (Denmark)

    Lund, S; Christiansen, Lars; Andersen, O. B.

    2009-01-01

    Gravity changes linearly with the change in soil water content. With the GRACE satellite mission the interest for ground-based gravity methods in hydrology has gained new attention. Time-lapse gravity data have the potential to constrain hydrological model parameters in a calibration scheme...... in water content, a controlled experiment was set up in 30 m by 20 m basin. The water table was lowered 0.69 m within 1½ hours and the corresponding gravity signal measured using two different approaches: a time series measurements at one location and a gravity network measurement including four points....... Both where in agreement with the calculated maximum theoretical gravity change of 27*10^-8 m/s^2. Uncertainties on the change in gravity in the network measurements where 4*10^-8 m/s^2 (one standard deviation). This corresponds to an infinite horizontal slab of water with a thickness of 0.1 m. The time...

  16. Far-forward collective scattering measurements of density fluctuations in the helically symmetric experiment stellarator.

    Science.gov (United States)

    Deng, C B; Brower, D L

    2010-10-01

    The multichannel interferometer system on the helically symmetric experiment (HSX) stellarator is reconfigured to perform far-forward collective scattering measurements of electron density fluctuations. The collective scattering system has nine viewing chords with 1.5 cm spacing. Scattered power is measured using a homodyne detection scheme. Far-forward collective scattering provides a line-integrated measurement of fluctuations within the divergence of the probe beam covering wavenumber range: k(⊥)<2 cm(-1). The perpendicular wavenumber consists of poloidal and radial contributions that vary with chord position. Both coherent modes and broadband fluctuation are measured. When HSX is operated without quasihelical symmetry at B(T)=1 T and n(e)∼4×10(12) cm(-3), a coherent electrostatic fluctuation is observed.

  17. Thermodynamic characteristics of the dissolution of glycine, glycylglycine, and glycylglycylglycine in aqueous solutions of sodium dodecyl sulfate at T = 298.15 K

    Science.gov (United States)

    Smirnov, V. I.; Badelin, V. G.

    2017-09-01

    the enthalpies of dissolution of glycine (Gly), glycylglycine (GlyGly), and glycylglycylglycine (GlyGlyGly) are measured in aqueous solutions of sodium dodecyl sulfate (SDS) at SDS concentrations m = 0-0.7 mol kg-1 and T = 298.15 K by means of calorimetry. The obtained data are used to calculate the standard values of enthalpies of dissolution (Δsol H m ) and enthalpies of transfer (Δtr H m ) of glycine and its oligomers from water to SDS aqueous solutions. The dependences of Δsol H m and Δtr H m on SDS concentration in an aqueous solution at a constant concentration of glycine and its oligomers are determined. A comparative analysis of the thermodynamic characteristics of Gly, GlyGly, and GlyGlyGly transfer within the studied range of SDS concentrations is performed. The results are interpreted in terms of ion-ion, ion-polar, and hydrophobic interactions between SDS and molecules of glycine and its oligomers.

  18. Apparent molar volumes and viscosity B-coefficients of glycine in aqueous silver sulphate solutions at T = (298.15, 308.15, 318.15) k.

    Science.gov (United States)

    Sinha, Biswajit; Roy, Pran Kumar; Roy, Mahendra Nath

    2010-09-01

    Apparent molar volumes (φV) and viscosity B-coefficients for glycine in 0.005, 0.010, 0.015, and 0.020 mol dm-3 aqueous silver sulphate (Ag2SO4) solutions have been determined from solution density and viscosity measurements at (298.15, 308.15, and 318.15) K as a function of glycine concentration. The standard partial molar volume (φV0) and experimental slopes (SV*) obtained from the Masson equation have been interpreted in terms of solute-solvent and solute-solute interactions, respectively. The viscosity data were analyzed using the Jones-Dole equation, and the derived parameters A and B were interpreted in terms of solute-solute and solute-solvent interactions, respectively. The standard volumes of transfer (ΔφV0) and viscosity B-coefficients of transfer (ΔB) of glycine from water to aqueous Ag2SO4 solutions were derived to study various interactions in the ternary solutions. The structure making or breaking ability of glycine has been discussed in terms of the sign of (δ2φV0/δT2)P. The activation parameters of viscous flow for the ternary solutions were also calculated and explained in terms of transition state theory.

  19. Measuring medicine-related experiences from the patient perspective: a systematic review

    Directory of Open Access Journals (Sweden)

    Katusiime B

    2016-10-01

    Full Text Available Barbra Katusiime,1 Sarah Corlett,1 Joanne Reeve,2 Janet Krska1 1Medway School of Pharmacy, The Universities of Kent and Greenwich, Chatham, Maritime, Kent, UK; 2Warwick Medical School, University of Warwick, Coventry, UK Background: There is an increasing drive to measure and so improve patients’ experiences and outcomes of health care. This also applies to medicines, given their ubiquity as health care interventions. Patients’ experiences of using medicines vary, and instruments which measure these are seen as an essential component to improve care. We aimed to identify generic measures of patients’ experiences of using prescription medicines and to examine their properties and suitability for use in research or practice. Methods: Multiple electronic databases were searched: MEDLINE, Embase, PsycINFO, PsycARTICLES, CINHAL Plus, PROQOLID®, and Google Scholar. We identified, critically appraised, and summarized generic questionnaires assessing one or more aspects of the medicine use experience among adult patients using prescription medicines for chronic conditions, and the process of questionnaire development, degree of patient involvement, and/or validation processes. Results: Fifteen questionnaires were included. Of these, nine measures were multidimensional, covering various aspects of medicine use. Six instruments covered only a single domain, assessing a specific facet of using medicines. Domains covered were the following: effectiveness; convenience, practicalities, and/or managing medicines; information, knowledge, and/or understanding; side effects; relationships and/or communication with health professionals; impact on daily living and/or social life; general satisfaction; attitudes; beliefs, concerns, and/or perceptions; medical follow-up and/or adherence-related issues; treatment- and/or medicine-related burden, perceived control, or autonomy; self-confidence about medicine use; availability and accessibility; and medicine

  20. Neutral Pion Transition Form Factor Measurement and Run Control at the NA62 experiment

    CERN Document Server

    AUTHOR|(CDS)2082375; Goudzovski, Evgueni

    The measurement of the 0 electromagnetic transition form factor (TFF) slope a is performed in the time-like region of momentum transfer using a sample of 1.1 $10^6$ $\\pi^0 \\to e^+ e^- \\gamma$ Dalitz decays collected at the NA62-RK experiment in 2007. The event selection, the fit procedure and the study of the systematic ffects are presented. The final result obtained $a = (3.68 \\pm 0.51stat \\pm 0.25syst) \\times 10^{-2} $ is the most precise to date and represents the first evidence of a non-zero $\\pi^0$ TFF slope with more than 3 $\\sigma$ significance. The NA62 experiment based at the CERN SPS is currently taking data and aims at measuring the branching fraction of the $K \\to \\pi \

  1. The PVLAS experiment: measuring vacuum magnetic birefringence and dichroism with a birefringent Fabry-Perot cavity

    Energy Technology Data Exchange (ETDEWEB)

    Della Valle, Federico; Milotti, Edoardo [INFN, Trieste (Italy); Universita di Trieste, Dipt. di Fisica, Trieste (Italy); Ejlli, Aldo; Messineo, Giuseppe; Zavattini, Guido [INFN, Ferrara (Italy); Universita di Ferrara, Dipt. di Fisica e Scienze della Terra, Ferrara (Italy); Gastaldi, Ugo [INFN, Ferrara (Italy); Pengo, Ruggero; Ruoso, Giuseppe [INFN, Lab. Nazionale di Legnaro, Legnaro (Italy)

    2016-01-15

    Vacuum magnetic birefringence was predicted long time ago and is still lacking a direct experimental confirmation. Several experimental efforts are striving to reach this goal, and the sequence of results promises a success in the next few years. This measurement generally is accompanied by the search for hypothetical light particles that couple to two photons. The PVLAS experiment employs a sensitive polarimeter based on a high finesse Fabry-Perot cavity. In this paper we report on the latest experimental results of this experiment. The data are analysed taking into account the intrinsic birefringence of the dielectric mirrors of the cavity. Besides a new limit on the vacuum magnetic birefringence, the measurements also allow the model-independent exclusion of new regions in the parameter space of axion-like and milli-charged particles. In particular, these last limits hold also for all types of neutrinos, resulting in a laboratory limit on their charge. (orig.)

  2. The PVLAS experiment: measuring vacuum magnetic birefringence and dichroism with a birefringent Fabry-Perot cavity

    CERN Document Server

    Della Valle, F; Ejlli, A; Gastaldi, U; Messineo, G; Zavattini, G; Pengo, R; Ruoso, G

    2015-01-01

    Vacuum magnetic birefringence was predicted long time ago and is still lacking a direct experimental confirmation. Several experimental efforts are striving to reach this goal, and the sequence of results promises a success in the next few years. This measurement generally is accompanied by the search for hypothetical light particles that couple to two photons. The PVLAS experiment employs a sensitive polarimeter based on a high finesse Fabry-Perot cavity. In this paper we report on the latest experimental results of this experiment. The data are analysed taking into account the intrinsic birefringence of the dielectric mirrors of the cavity. Besides the limit on the vacuum magnetic birefringence, the measurements also allow the model-independent exclusion of new regions in the parameter space of axion-like and milli-charged particles. In particular, these last limits hold also for all types of neutrinos, resulting in a laboratory limit on their charge.

  3. Staged Z-pinch Experiments at the 1MA Zebra pulsed-power generator: Neutron measurements

    Science.gov (United States)

    Ruskov, Emil; Darling, T.; Glebov, V.; Wessel, F. J.; Anderson, A.; Beg, F.; Conti, F.; Covington, A.; Dutra, E.; Narkis, J.; Rahman, H.; Ross, M.; Valenzuela, J.

    2017-10-01

    We report on neutron measurements from the latest Staged Z-pinch experiments at the 1MA Zebra pulsed-power generator. In these experiments a hollow shell of argon or krypton gas liner, injected between the 1 cm anode-cathode gap, compresses a deuterium plasma target of varying density. Axial magnetic field Bz liquid scintillator detector to which fast gatedPhotek photomultipliers are attached. Sample data from these neutron diagnostics systems is presented. Consistently high neutron yields YDD >109 are measured, with highest yield of 2.6 ×109 . A pair of horizontally and vertically placed plastic scintillator nTOFs suggest isotropic i.e. thermonuclear origin of the neutrons produced. nTOF data from the liquid scintillator detector was cross-calibrated with the silver activation detector, and can be used for accurate calculation of the neutron yield. Funded by the Advanced Research Projects Agency - Energy, under Grant Number DE-AR0000569.

  4. Using patient experiences as an outcome of integrated care. How to measure it?

    DEFF Research Database (Denmark)

    Nicolaisen, Anne; Fallesen, Anne Kudsk; Rasmussen, Hanna Barbara

    2016-01-01

    and rehabilitation. The purpose of this project is to identify how patients conceptualize clinical integration and how this resembles key features for clinical integration identified by clinicians. Further, we want to develop a patient questionnaire measuring their experience of clinical integration. Method: We......, and patients with chronic and transitory conditions. Data from the semi-structured interviews will be analyzed using grounded theory identifying themes that are important to patients in inter-sectorial clinical pathways. The identified themes will be compared to themes identified in the literature...... and the three subscales of the Nijmegen Continuity Questionnaire (NCQ)(2). Based on the comparison of themes, we will develop a questionnaire and do a pilot test. Progress report: We searched the literature for articles and reports surveys measuring different aspects of patient experiences on clinical...

  5. Using particle tracking to measure flow instabilities in an undergraduate laboratory experiment

    Science.gov (United States)

    Kelley, Douglas H.; Ouellette, Nicholas T.

    2011-03-01

    Much of the drama and complexity of fluid flow occurs because its governing equations lack unique solutions. The observed behavior depends on the stability of the multitude of solutions, which can change with the experimental parameters. Instabilities cause sudden global shifts in behavior. We have developed a low-cost experiment to study a classical fluid instability. By using an electromagnetic technique, students drive Kolmogorov flow in a thin fluid layer and measure it quantitatively with a webcam. They extract positions and velocities from movies of the flow using Lagrangian particle tracking and compare their measurements to several theoretical predictions, including the effect of the drive current, the spatial structure of the flow, and the parameters at which instability occurs. The experiment can be tailored to undergraduates at any level or to graduate students by appropriate emphasis on the physical phenomena and the sophisticated mathematics that govern them.

  6. Optical transition radiation measurements for the Los Alamos and Boeing Free-Electron Laser experiments

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H.; Feldman, R.B.; Feldman, D.W.; Apgar, S.A.; Calsten, B.E.; Fiorito, R.B.; Rule, D.W.

    1988-01-01

    Optical transition radiation (OTR) measurements of the electron-beam emittance have been performed at a location just before the wiggler in the Los Alamos Free-Electron Laser (FEL) experiment. Beam profiles and beam divergence patterns from a single macropulse were recorded simultaneously using two intensified charge-injection device (CID) television cameras and an optical beamsplitter. Both single-foil OTR and two-foil OTR interference experiments were performed. Preliminary results are compared to a reference variable quadrupole, single screen technique. New aspects of using OTR properties for pointing the e-beam on the FEL oscillator axis, as well as measuring e-beam emittance are addressed. 7 refs., 9 figs.

  7. Measurements of Discrete Symmetries in the Neutral Kaon System with the CPLEAR (PS195) Experiment

    CERN Document Server

    Ruf, Thomas

    2015-01-01

    The antiproton storage ring LEAR offered unique opportunities to study the symmetries which exist between matter and antimatter. At variance with other approaches at this facility, CPLEAR was an experiment devoted to the study of T, CPT and CP symmetries in the neutral kaon system. It measured with high precision the time evolution of initially strangeness-tagged $K^0$ and $\\bar{K}^0$ states to determine the size of violations with respect to these symmetries in the context of a systematic study. In parallel, limits concerning quantum-mechanical predictions (EPR paradox, coherence of the wave function) or the equivalence principle of general relativity have been obtained. This article will first discuss briefly the unique low energy antiproton storage ring LEAR followed by a description of the CPLEAR experiment, including the basic formalism necessary to understand the time evolution of a neutral kaon state and the main results related to measurements of discrete symmetries in the neutral kaon system. An exce...

  8. Airborne radar and radiometer experiment for quantitative remote measurements of rain

    Science.gov (United States)

    Kozu, Toshiaki; Meneghini, Robert; Boncyk, Wayne; Wilheit, Thomas T.; Nakamura, Kenji

    1989-01-01

    An aircraft experiment has been conducted with a dual-frequency (10 GHz and 35 GHz) radar/radiometer system and an 18-GHz radiometer to test various rain-rate retrieval algorithms from space. In the experiment, which took place in the fall of 1988 at the NASA Wallops Flight Facility, VA, both stratiform and convective storms were observed. A ground-based radar and rain gauges were also used to obtain truth data. An external radar calibration is made with rain gauge data, thereby enabling quantitative reflectivity measurements. Comparisons between path attenuations derived from the surface return and from the radar reflectivity profile are made to test the feasibility of a technique to estimate the raindrop size distribution from simultaneous radar and path-attenuation measurements.

  9. Interpretation of the electric fields measured in an ionospheric critical ionization velocity experiment

    Science.gov (United States)

    Brenning, N.; Faelthammar, C.-G.; Marklund, G.; Haerendel, G.; Kelley, M. C.; Pfaff, R.

    1991-01-01

    The quasi-dc electric fields measured in the CRIT I ionospheric release experiment are studied. In the experiment, two identical barium shaped charges were fired toward a main payload, and three-dimensional measurements of the electric field inside the streams were made. The relevance of proposed mechanisms for electron heating in the critical ionization velocity (CIV) mechanism is addressed. It is concluded that both the 'homogeneous' and the 'ionizing front' models probably are valid, but in different parts of the streams. It is also possible that electrons are directly accelerated by a magnetic field-aligned component of the electric field. The coupling between the ambient ionosphere and the ionized barium stream is more complicated that is usually assumed in CIV theories, with strong magnetic-field-aligned electric fields and probably current limitation as important processes.

  10. The Awful Truth About Zero-Gravity: Space Acceleration Measurement System; Orbital Acceleration Research Experiment

    Science.gov (United States)

    2002-01-01

    Earth's gravity holds the Shuttle in orbit, as it does satellites and the Moon. The apparent weightlessness experienced by astronauts and experiments on the Shuttle is a balancing act, the result of free-fall, or continuously falling around Earth. An easy way to visualize what is happening is with a thought experiment that Sir Isaac Newton did in 1686. Newton envisioned a mountain extending above Earth's atmosphere so that friction with the air would be eliminated. He imagined a cannon atop the mountain and aimed parallel to the ground. Firing the cannon propels the cannonball forward. At the same time, Earth's gravity pulls the cannonball down to the surface and eventual impact. Newton visualized using enough powder to just balance gravity so the cannonball would circle the Earth. Like the cannonball, objects orbiting Earth are in continuous free-fall, and it appears that gravity has been eliminated. Yet, that appearance is deceiving. Activities aboard the Shuttle generate a range of accelerations that have effects similar to those of gravity. The crew works and exercises. The main data relay antenna quivers 17 times per second to prevent 'stiction,' where parts stick then release with a jerk. Cooling pumps, air fans, and other systems add vibration. And traces of Earth's atmosphere, even 200 miles up, drag on the Shuttle. While imperceptible to us, these vibrations can have a profound impact on the commercial research and scientific experiments aboard the Shuttle. Measuring these forces is necessary so that researchers and scientists can see what may have affected their experiments when analyzing data. On STS-107 this service is provided by the Space Acceleration Measurement System for Free Flyers (SAMS-FF) and the Orbital Acceleration Research Experiment (OARE). Precision data from these two instruments will help scientists analyze data from their experiments and eliminate outside influences from the phenomena they are studying during the mission.

  11. Measurements of the Top-Higgs Coupling with the CMS Experiment

    CERN Document Server

    Mildner, Hannes

    The top-Higgs coupling is constrained using data measured with the CMS experiment in LHC Run 1 and 2. Constraints on anomalous top-Higgs couplings are derived by re-analyzing CMS Run 1 measurements. Furthermore, a search for Higgs production in association with a top-quark pair and Higgs-boson decays into b-quarks in Run 2 data is presented. Upper limits on ttH production are calculated and it is demonstrated that the analysis can also be used to constrain anomalous top-Higgs couplings.

  12. Electro-optical propagation measurements during the MINOTAUROS experiment in the Cretan Sea

    Science.gov (United States)

    Eisele, Christian; Sucher, Erik; Wendelstein, Norbert; Stein, Karin

    2017-09-01

    We report on propagation measurements performed during the MINOTAUROS (Maritime INvestigations On Targets and Atmosphere Under Reduction of Optical Signatures) experiment on Crete, Greece, in late summer of 2016. The field trial has been organized by NATO STO Task Group SET-211 on Naval Platform Protection in the EO/IR Domain with strong support of the Hellenic Navy. Besides meteorological measurements, the experiment included measurements of turbulence using a boundary layer scintillometer on a slant path (d = 8 km) across the entry of Souda Bay (Crete). These are compared to values obtained by a 3D sonic anemometer, which was deployed at one end of the propagation path. Refraction effects have been measured using a 17.5 km path from Drapanos to Gerani. Two meteorological buoys along the path were used to gather information about the atmospheric conditions. An overview and a first analysis of the results are presented. The refraction measurements are compared to simulations using MORTICIA (Model of Range and Transmission in Coastal Inland Atmospheres), a new software tool currently under development in a collaboration of Fraunhofer IOSB and TNO.

  13. Double slit experiment with quantum detectors: mysteries, meanings, misinterpretations and measurement

    Science.gov (United States)

    Rameez-ul-Islam; Ikram, Manzoor; Hasan Mujtaba, Abid; Abbas, Tasawar

    2018-01-01

    We propose an idea for symmetric measurements through the famous double slit experiment (DSE) in a new detection scenario. The interferometric setup is complemented here with quantum detectors that switch to an arbitrary superposition after interaction with the arms of the DSE. The envisioned schematics cover the full measurement range, i.e. from the weak to the strong projective situation with selectivity being a smoothly tunable open option, and suggests an alternative methodology for weak measurements based on information overlap from DSE paths. The results, though generally in agreement with the quantum paradigm, raise many questions over the nature of probabilities, the absurdity of the common language for phenomena’s description in the theory and the boundary separating the projective/non-projective measurements, and the related misconceived interpretations. Further, the results impose certain constraints over the hidden variable theories as well as on the repercussions of the weak measurements. Although described as a thought experiment, the proposal can equally be implemented experimentally under a prevailing research scenario.

  14. Final scientific and technical report: New experiments to measure the neutrino mass scale

    Energy Technology Data Exchange (ETDEWEB)

    Monreal, Benjamin [Univ. of California, Santa Barbara, CA (United States)

    2016-11-19

    In this work, we made material progress towards future measurements of the mass of the neutrino. The neutrino is a fundamental particle, first observed in the 1950s and subjected to particularly intense study over the past 20 years. It is now known to have some, non-zero mass, but we are in an unusual situation of knowing the mass exists but not knowing what value it takes. The mass may be determined by precise measurements of certain radioactive decay distributions, particularly the beta decay of tritium. The KATRIN experiment is an international project which is nearing the beginning of a tritium measurement campaign using a large electrostatic spectrumeter. This research included participation in KATRIN, including construction and delivery of a key calibration subsystem, the ``Rear Section''. To obtain sensitivity beyond KATRIN's, new techniques are required; this work included R&D on a new technique we call CRES (Cyclotron Resonance Electron Spectroscopy) which has promise to enable even more sensitive tritium decay measurements. We successfully carried out CRES spectroscopy in a model system in 2014, making an important step towards the design of a next-generation tritium experiment with new neutrino mass measurement abilities.

  15. Glycine receptors in the human substantia nigra as defined by (3H)strychnine binding

    Energy Technology Data Exchange (ETDEWEB)

    de Montis, G.; Beaumont, K.; Javoy-Agid, F.; Agid, Y.; Constandinidis, J.; Lowenthal, A.; Lloyd, K.G.

    1982-03-01

    Specific (3H)strychnine binding was used to identify the glycine receptor macromolecular complex in human spinal cord, substantia nigra, inferior olivary nucleus, and cerebral cortex. In material from control patients a high-affinity KD (3--8 nM) was observed in the spinal cord and the substantia nigra, both the pars compacta and the pars reticulata. This is very similar to the values observed in the rat and bovine spinal cord (8 and 3 nM, respectively) and rat substantia nigra (12 nM). In the human brain the distribution of (3H)strychnine binding (at 10 nM) was: spinal cord . substantia nigra, pars compacta greater than substantia nigra, pars reticulata . inferior olivary nucleus greater than cerebral cortex. The binding capacity (Bmax) of the rat brain (substantia nigra or spinal cord) was approximately 10-fold that of the human brain. (3H)Strychnine binding was significantly decreased in the substantia nigra from Parkinson's disease patients, both in the pars compacta (67% of control) and the pars reticulata (50% of control), but not in the inferior olivary nucleus. The results were reproduced in preliminary experiment in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. In the substantia nigra from patients who died with Huntington's disease, (3H)strychnine binding tended to be high (150% of control, NS) in both the pars compacta and the reticulata. (3H)Strychnine binding was unaltered in the substantia nigra of patients with senile dementia. Together with previous neurophysiological and neuropharmacological findings, those results support the hypothesis of glycine receptors occurring on dopamine cell bodies and/or dendrites in the substantia nigra.

  16. The Play Experience Scale: development and validation of a measure of play.

    Science.gov (United States)

    Pavlas, Davin; Jentsch, Florian; Salas, Eduardo; Fiore, Stephen M; Sims, Valerie

    2012-04-01

    A measure of play experience in video games was developed through literature review and two empirical validation studies. Despite the considerable attention given to games in the behavioral sciences, play experience remains empirically underexamined. One reason for this gap is the absence of a scale that measures play experience. In Study 1, the initial Play Experience Scale (PES) was tested through an online validation that featured three different games (N = 203). In Study 2, a revised PES was assessed with a serious game in the laboratory (N = 77). Through principal component analysis of the Study 1 data, the initial 20-item PES was revised, resulting in the 16-item PES-16. Study 2 showed the PES-16 to be a robust instrument with the same patterns of correlations as in Study 1 via (a) internal consistency estimates, (b) correlations with established scales of motivation, (c) distributions of PES-16 scores in different game conditions, and (d) examination of the average variance extracted of the PES and the Intrinsic Motivation Scale. We suggest that the PES is appropriate for use in further validation studies. Additional examinations of the scale are required to determine its applicability to other contexts and its relationship with other constructs. The PES is potentially relevant to human factors undertakings involving video games, including basic research into play, games, and learning; prototype testing; and exploratory learning studies.

  17. Behavioral differences of Heterodera glycines and Meloidogyne incognita infective juveniles exposed to root extracts in vitro

    Science.gov (United States)

    The in vitro behaviors of infective juveniles (J2) of Heterodera glycines and Meloidogyne incognita were compared in the presence and absence of plant root extracts. In an agar plate attraction-retention assay, H. glycines was 15-fold more responsive to a chemical attractant (CaCl2; P < 0.05) than w...

  18. Crystal lattice dependency of the free radicals found in irradiated glycine

    NARCIS (Netherlands)

    Bie, M.J.A. de; Braams, R.

    1969-01-01

    The EPR spectra, and hence the stable free radicals, are different for the - or γ-irradiated α-, β- and γ-crystal forms of polycrystalline glycone. Therefore comparisons of the trideutero-glycine EPR spectrum with the EPR spectra of non-deuterated glycine are open to question

  19. Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits

    DEFF Research Database (Denmark)

    Pless, Stephan Alexander; Lynch, Joseph W

    2009-01-01

    glycine activation but not during ivermectin activation. This prompted the hypothesis that this signal reports a glycine-mediated conformational change not essential for activation. We tested this by investigating whether the fluorescence signal depended on whether the fluorophore was attached...

  20. Identificatoin and confirmation of resistance against soybean aphid (Aphis glycines) in eight wild soybean lines

    Science.gov (United States)

    The development and use of aphid-resistant soybean (Glycine max) cultivars has been complicated by the presence of multiple virulent biotypes of the soybean aphid (SA, Aphis glycines Matsumura). Ultimately, a variety of unique resistance sources may be needed to develop cultivars with a broad spectr...

  1. Kinetics and mechanism of oxidation of glycine by iron (III)-1, 10 ...

    Indian Academy of Sciences (India)

    Kinetics and mechanism of oxidation of glycine by iron(III)-1,10-phenanthroline complex has been studied in perchloric acid medium. The reaction is first order with respect to iron(III) and glycine. An increase in (phenanthroline) increases the rate, while increase in [H+] decreases the rate. Hence it can be inferred that the ...

  2. Stoichiometry of Zn(II)-heparin-glycine complex, determined using data from elemental and thermal analysis

    Science.gov (United States)

    Feofanova, M. A.; Skobin, M. I.; Kryukov, T. V.; Alekseev, V. G.; Ryasenskii, S. S.

    2017-10-01

    Ternary polymer Zn(II)-heparin-glycine complex with the composition {Na3[ZnHepGly]·H2O} n , where Hep4- is the monomer chain of a heparin polyanion and Gly- is the chain of a glycine anion, is isolated in a solid state from a water solution, and is characterized via elemental and thermal analysis.

  3. Hydrogen bond mediated stabilization of the salt bridge structure for the glycine dimer anion

    NARCIS (Netherlands)

    Heiles, S.; Cooper, R.J.; Berden, G.; Oomens, J.; Williams, E.R.

    2015-01-01

    The formation of a salt bridge in deprotonated glycine dimer anions in a solvent-free environment is investigated using both infrared multiple photon dissociation spectroscopy between 600 and 1800 cm(-1) and theory. The zwitterionic and nonzwitterionic forms of glycine in this complex are computed

  4. Light intensity affects the uptake and metabolism of glycine by pakchoi (Brassica chinensis L.)

    Science.gov (United States)

    Ma, Qingxu; Cao, Xiaochuang; Wu, Lianghuan; Mi, Wenhai; Feng, Ying

    2016-02-01

    The uptake of glycine by pakchoi (Brassica chinensis L.), when supplied as single N-source or in a mixture of glycine and inorganic N, was studied at different light intensities under sterile conditions. At the optimal intensity (414 μmol m-2 s-1) for plant growth, glycine, nitrate, and ammonium contributed 29.4%, 39.5%, and 31.1% shoot N, respectively, and light intensity altered the preferential absorption of N sources. The lower 15N-nitrate in root but higher in shoot and the higher 15N-glycine in root but lower in shoot suggested that most 15N-nitrate uptake by root transported to shoot rapidly, with the shoot being important for nitrate assimilation, and the N contribution of glycine was limited by post-uptake metabolism. The amount of glycine that was taken up by the plant was likely limited by root uptake at low light intensities and by the metabolism of ammonium produced by glycine at high light intensities. These results indicate that pakchoi has the ability to uptake a large quantity of glycine, but that uptake is strongly regulated by light intensity, with metabolism in the root inhibiting its N contribution.

  5. Protease inhibition by Heterodera glycines cyst content: evidence for effects on the Meloidogyne incognita proteasome

    Science.gov (United States)

    Proteases from Heterodera glycines and Meloidogyne incognita juveniles were inhibited by heat-stable content of H. glycines female cysts (HglCE), and by the plant polyphenol epigallocatechin gallate (EGCG). General protease activities detected using the nematode peptide KSAYMRFa were inhibited by EG...

  6. THE INCORPORATION OF RADIOACTIVITY FROM GLYCINE-C$sup 14$ BY MAMMALIAN SPERMATOZOA

    Energy Technology Data Exchange (ETDEWEB)

    Graves, C.N.

    1962-05-15

    The metabolic pathways of glycine incorporation were investigated by biochemical and radibautographic methods. Results show that glycine is utilized hy bovine spermatoza and is incorporated into all fractions of the sperm cell. Incorporation into the nucleic acid fraction and especially into thymine indicates that there is a turnover in the desoxyribenucleic acid during storage of bovine spermatoza. (C.H.)

  7. Environmental adaptation in wild soybeans (Glycine soja) across their native geographic range in northeast Asia

    Science.gov (United States)

    Understanding the genetic basis of adaptive variation and the forces that shape this diversity in natural populations are long-standing goals in evolutionary biology. The wild soybean (Glycine soja), from which domesticated soybeans (Glycine max) were derived, is widely distributed throughout a dive...

  8. Benchmark experiment on vanadium assembly with D-T neutrons. Leakage neutron spectrum measurement

    Energy Technology Data Exchange (ETDEWEB)

    Kokooo; Murata, I.; Nakano, D.; Takahashi, A. [Osaka Univ., Suita (Japan); Maekawa, F.; Ikeda, Y.

    1998-03-01

    The fusion neutronics benchmark experiments have been done for vanadium and vanadium alloy by using the slab assembly and time-of-flight (TOF) method. The leakage neutron spectra were measured from 50 keV to 15 MeV and comparison were done with MCNP-4A calculations which was made by using evaluated nuclear data of JENDL-3.2, JENDL-Fusion File and FENDL/E-1.0. (author)

  9. The SOFIA experiment: Measurement of 236U fission fragment yields in inverse kinematics

    Directory of Open Access Journals (Sweden)

    Grente L.

    2016-01-01

    Full Text Available The SOFIA (Studies On FIssion with Aladin experiment aims at measuring fission-fragments isotopic yields with high accuracy using inverse kinematics at relativistic energies. This experimental technique allows to fully identify the fission fragments in nuclear charge and mass number, thus providing very accurate isotopic yields for low energy fission of a large variety of fissioning systems. This report focuses on the latest results obtained with this set-up concerning electromagnetic-induced fission of 236U.

  10. The SOFIA experiment: Measurement of 236U fission fragment yields in inverse kinematics

    Science.gov (United States)

    Grente, L.; Taïeb, J.; Chatillon, A.; Martin, J.-F.; Pellereau, É.; Boutoux, G.; Gorbinet, T.; Bélier, G.; Laurent, B.; Alvarez-Pol, H.; Ayyad, Y.; Benlliure, J.; Caamaño, M.; Audouin, L.; Casarejos, E.; Cortina-Gil, D.; Farget, F.; Fernández-Domínguez, B.; Heinz, A.; Jurado, B.; Kelić-Heil, A.; Kurz, N.; Lindberg, S.; Löher, B.; Nociforo, C.; Paradela, C.; Pietri, S.; Ramos, D.; Rodriguez-Sanchez, J.-L.; Rodríguez-Tajes, C.; Rossi, D.; Schmidt, K.-H.; Simon, H.; Tassan-Got, L.; Törnqvist, H.; Vargas, J.; Voss, B.; Weick, H.; Yan, Y.

    2016-06-01

    The SOFIA (Studies On FIssion with Aladin) experiment aims at measuring fission-fragments isotopic yields with high accuracy using inverse kinematics at relativistic energies. This experimental technique allows to fully identify the fission fragments in nuclear charge and mass number, thus providing very accurate isotopic yields for low energy fission of a large variety of fissioning systems. This report focuses on the latest results obtained with this set-up concerning electromagnetic-induced fission of 236U.

  11. Cross Section Measurements and Charm Production in the NuTeV Experiment

    Science.gov (United States)

    Boyd, S.; Adams, T.; Alton, A.; Avvakumov, S.; de Barbaro, L.; de Barbaro, P.; Bernstein, R. H.; Bodek, A.; Bolton, T.; Brau, J.; Buchholz, D.; Budd, H.; Bugel, L.; Conrad, J.; Drucker, R. B.; Fleming, B. T.; Formaggio, J.; Frey, R.; Goldman, J.; Goncharov, M.; Harris, D. A.; Johnson, R. A.; Kim, J. H.; Koutsoliotas, S.; Lamm, M. J.; Marsh, W.; Mason, D.; McDonald, J.; McFarland, K. S.; McNulty, C.; Naples, D.; Nienaber, P.; Radescu, V.; Romosan, A.; Sakumoto, W. K.; Schellman, H.; Shaevitz, M. H.; Spentzouris, P.; Stern, E. G.; Suwonjandee, N.; Tobien, N.; Vaitaitis, A.; Vakili, M.; Yang, U. K.; Yu, J.; Zeller, G. P.; Zimmerman, E. D.

    2004-02-01

    The NuTeV experiment at Fermilab obtained pure high statistics samples of neutrino and antineutrino interactions using its sign-selected beam. Preliminary inclusive charged current differential cross sections of neutrino and antineutrino interactions on iron are presented, along with preliminary measurements of F2(x, Q2) and xF3(x, Q2). Preliminary results from the next-to-leading order QCD analysis of deep inelastic charged current dimuon data are also shown.

  12. Measuring patients’ experiences with palliative care: the Consumer Quality Index Palliative Care.

    OpenAIRE

    Claessen, S.J.J.; Francke, A.L.; Sixma, H.J.; Veer, A.J.E. de; Deliens, L.

    2012-01-01

    Background: The Consumer Quality Index Palliative Care (CQ-index PC) is a structured questionnaire for measuring the quality of palliative care from the perspective of care users. CQ-indices assess which care aspects need quality improvement by relating answers about actual care experiences to answers about the importance of certain aspects of care. Methods: To improve the chance that the new instrument has good content validity, a literature study and individual and group discussions were pe...

  13. Thermodynamic and spectroscopic study of Al3+interaction with glycine, l-cysteine and tranexamic acid in aqueous solution.

    Science.gov (United States)

    Cardiano, Paola; Giacobello, Fausta; Giuffrè, Ottavia; Sammartano, Silvio

    2017-11-01

    In this paper a thermodynamic and spectroscopic study on the interaction between Al 3+ and glycine (Gly), l-cysteine (Cys), tranexamic acid (Tranex) is reported. Speciation models have been obtained by processing potentiometric titration data to determine stability constants of the species formed in aqueous solution at T=298.15K, 0.15≤I/molL -1 ≤1 in NaCl. Thermodynamic formation parameters have been obtained from calorimetric titration data, at T=298.15K, I=0.15molL -1 using NaCl as ionic medium. Al 3+ -Cys system was also investigated by spectrophotometric and 1 H NMR measurements. 1 H NMR experiments were performed on Al 3+ -Tranex system as well. Different speciation models have been observed for the three systems. The results showed the formation of MLH, ML and M 2 L 2 (OH) 2 species for Gly, ML, M 2 L and MLOH for Cys, MLH and MLOH for Tranex. The formed species are quite stable, i.e. for ML, logβ=7.18, 11.91 for Gly and Cys, respectively, at I=0.15molL -1 and T=298.15K. For all the systems the dependence of formation constants on ionic strength over the range 0.1-1molL -1 is reported. The sequestering ability of the ligands under study was also evaluated by pL 0.5 empiric parameter. For Gly, Cys and Tranex, pL 0.5 =2.51, 3.74, 3.91 respectively, at pH=5, I=0.15molL -1 and T=298.15K. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Alone or together: measuring users' viewing experience in different social contexts

    Science.gov (United States)

    Zhu, Yi; Heynderickx, Ingrid; Redi, Judith A.

    2014-02-01

    In the past decades, a lot of effort has been invested in predicting the users' Quality of Visual Experience (QoVE) in order to optimize online video delivery. So far, the objective approaches to measure QoVE have been mainly based on an estimation of the visibility of artifacts generated by signal impairments at the moment of delivery and on a prediction of how annoying these artifacts are to the end user. Recently, it has been shown that other aspects, such as user interest or viewing context, also have a crucial influence on QoVE. Social context is one of these aspects, but it has been poorly investigated in relation to QoVE so far. In this paper, we report the outcomes of an experiment that aims at unveiling the role that social context, and in particular co-located co-viewing, plays within the visual experience and the annoyance of coding artifacts. The results show that social context significantly influences user's QoVE, whereas the appearance of artifacts doesn't have impact on viewing experience, although users can still notice them. The results suggest that quantifying the impact of social context on user experience is of major importance to accurately predict QoVE towards video delivery optimization.

  15. Longitudinal measurement equivalence of subjective language brokering experiences scale in Mexican American adolescents.

    Science.gov (United States)

    Kim, Su Yeong; Hou, Yang; Shen, Yishan; Zhang, Minyu

    2017-04-01

    Language brokering occurs frequently in immigrant families and can have significant implications for the well-being of family members involved. The present study aimed to develop and validate a measure that can be used to assess multiple dimensions of subjective language brokering experiences among Mexican American adolescents. Participants were 557 adolescent language brokers (54.2% female, Mage.wave1 = 12.96, SD = .94) in Mexican American families. Using exploratory and confirmatory factor analyses, we were able to identify 7 reliable subscales of language brokering: linguistic benefits, socioemotional benefits, efficacy, positive parent-child relationships, parental dependence, negative feelings , and centrality . Tests of factorial invariance show that these subscales demonstrate, at minimum, partial strict invariance across time and across experiences of translating for mothers and fathers, and in most cases, also across adolescent gender, nativity, and translation frequency. Thus, in general, the means of the subscales and the relations among the subscales with other variables can be compared across these different occasions and groups. Tests of criterion-related validity demonstrated that these subscales correlated, concurrently and longitudinally, with parental warmth and hostility, parent-child alienation, adolescent family obligation, depressive symptoms, resilience, and life meaning. This reliable and valid subjective language brokering experiences scale will be helpful for gaining a better understanding of adolescents' language brokering experiences with their mothers and fathers, and how such experiences may influence their development. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  16. Comparative metabolomics in Glycine max and Glycine soja under salt stress to reveal the phenotypes of their offspring.

    Science.gov (United States)

    Lu, Yonghai; Lam, Honming; Pi, Erxu; Zhan, Qinglei; Tsai, Sauna; Wang, Chunmei; Kwan, Yiuwa; Ngai, Saiming

    2013-09-11

    Metabolomics is developing as an important functional genomics tool for understanding plant systems' response to genetic and environmental changes. Here, we characterized the metabolic changes of cultivated soybean C08 (Glycine max L. Merr) and wild soybean W05 (Glycine soja Sieb.et Zucc.) under salt stress using MS-based metabolomics, in order to reveal the phenotypes of their eight hybrid offspring (9H0086, 9H0124, 9H0391, 9H0736, 9H0380, 9H0400, 9H0434, and 9H0590). Total small molecule extracts of soybean seedling leaves were profiled by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-Fourier transform mass spectrometry (LC-FT/MS). We found that wild soybean contained higher amounts of disaccharides, sugar alcohols, and acetylated amino acids than cultivated soybean, but with lower amounts of monosaccharides, carboxylic acids, and unsaturated fatty acids. Further investigations demonstrated that the ability of soybean to tolerate salt was mainly based on synthesis of compatible solutes, induction of reactive oxygen species (ROS) scavengers, cell membrane modifications, and induction of plant hormones. On the basis of metabolic phenotype, the salt-tolerance abilities of 9H0086, 9H0124, 9H0391, 9H0736, 9H0380, 9H0400, 9H0434, and 9H0590 were discriminated. Our results demonstrated that MS-based metabolomics provides a fast and powerful approach to discriminate the salt-tolerance characteristics of soybeans.

  17. Guidelines for measuring and reporting environmental parameters for experiments in greenhouses.

    Science.gov (United States)

    Both, A J; Benjamin, L; Franklin, J; Holroyd, G; Incoll, L D; Lefsrud, M G; Pitkin, G

    2015-01-01

    The importance of appropriate, accurate measurement and reporting of environmental parameters in plant sciences is a significant aspect of quality assurance for all researchers and their research. There is a clear need for ensuring research across the world can be compared, understood and where necessary replicated by fellow researchers. A common set of guidelines to educate, assist and encourage comparativeness is of great importance. On the other hand, the level of effort and attention to detail by an individual researcher should be commensurate with the particular research being conducted. For example, a researcher focusing on interactions of light and temperature should measure all relevant parameters and report a measurement summary that includes sufficient detail allowing for replication. Such detail may be less relevant when the impact of environmental parameters on plant growth and development is not the main research focus. However, it should be noted that the environmental experience of a plant during production can have significant impact when subsequent experiments investigate plants at a molecular, biochemical or genetic level or where species interactions are considered. Thus, researchers are encouraged to make a critical assessment of what parameters are of primary importance in their research and these parameters should be measured and reported. This paper brings together a collection of parameters that the authors, as members of International Committee on Controlled Environment Guidelines (ICCEG) in consultation with members of our three parent organizations, believe constitute those which should be recorded and reported when publishing scientific data from experiments in greenhouses. It provides recommendations to end users on when, how and where these parameters should be measured along with the appropriate internationally standardized units that should be used.

  18. ELABORATING A MEASUREMENT INSTRUMENT FOR THE FLOW EXPERIENCE DURING ONLINE INFORMATION SEARCH

    Directory of Open Access Journals (Sweden)

    Caraivan Luiza

    2012-12-01

    Full Text Available Flow is a construct imported in marketing research from social sciences in order to examine consumer behavior in the online medium. The construct describes a state of deep involvement in a challenging activity, most frequently characterized by high levels of enjoyment, control and concentration. Researchers found that the degree to which online experience is challenging can be defined, measured, and related well to important marketing variables. As shown by our extensive literature review, flow measurements include antecedents, dimensions and consequences of flow. The present paper represents a detailed description of the construct`s operationalization in the context of online information search. In this respect, our main goal is to produce a basic instrument to evaluate the flow experience of online search, in order to capitalize on the premises of an interactive, complex informational medium – the World Wide Web – and on the consequence of an exploratory informational behavior of users. The instrument is conceived to offer a primal possibility to collect data. The composition, source and significance of the 11 scales used to measure the multiple factors of the flow experience during online search are detailed in this study with the aim to ensure the compliance with scientific rigors and to facilitate correct reports of data related to the reliability and validity of measurements. For further research, we propose factor analysis to test the resulted instrument and to ensure that the measures employed are psychometrically sound. Factor analysis refers to a wide range of statistic techniques used to represent a set of variables in concordance with a reduced number of hypothetical variables called factors. Factorial analysis is used to solve two types of problems: reducing the number of variables to increase data processing speed and identifying hidden patterns in the existent data relations. However, we expect our scales to perform

  19. Size-Dependent Affinity of Glycine and Its Short Oligomers to Pyrite Surface: A Model for Prebiotic Accumulation of Amino Acid Oligomers on a Mineral Surface

    Directory of Open Access Journals (Sweden)

    Rehana Afrin

    2018-01-01

    Full Text Available The interaction strength of progressively longer oligomers of glycine, (Gly, di-Gly, tri-Gly, and penta-Gly, with a natural pyrite surface was directly measured using the force mode of an atomic force microscope (AFM. In recent years, selective activation of abiotically formed amino acids on mineral surfaces, especially that of pyrite, has been proposed as an important step in many origins of life scenarios. To investigate such notions, we used AFM-based force measurements to probe possible non-covalent interactions between pyrite and amino acids, starting from the simplest amino acid, Gly. Although Gly itself interacted with the pyrite surface only weakly, progressively larger unbinding forces and binding frequencies were obtained using oligomers from di-Gly to penta-Gly. In addition to an expected increase of the configurational entropy and size-dependent van der Waals force, the increasing number of polar peptide bonds, among others, may be responsible for this observation. The effect of chain length was also investigated by performing similar experiments using l-lysine vs. poly-l-lysine (PLL, and l-glutamic acid vs. poly-l-glutamic acid. The results suggest that longer oligomers/polymers of amino acids can be preferentially adsorbed on pyrite surfaces.

  20. A full Stokes vector ellipsometry measurement system for in situ diagnostics in dynamic experiments.

    Science.gov (United States)

    Bakshi, L; Eliezer, S; Appelbaum, G; Nissim, N; Perelmutter, L; Mond, M

    2012-05-01

    A fast ellipsometry system with a resolution of only a few nanoseconds that can simultaneously measure all four Stokes parameters was developed for use in dynamic experiments. Due to its fine temporal resolution, the system is useful for a wide variety of dynamic setups, two of which are presented, fast foil heating and shock compression. As a test case the optical properties of nickel were measured in a fast foil heating setup. The complex index of refraction and emissivity at 532 nm and in the range of 1000-1900 K are presented. It was found that the emissivity monotonously increases below and above the melting point while an abrupt increase of about 2% was observed at the phase transition. These results are in accordance with the literature. Shock compression experiments included sample-free surface measurements. Samples of 1020 steel were shocked up to 25 GPa on the Hugoniot curve. The measured optical properties under these conditions showed a significant change; the value of the emissivity was doubled.

  1. The TOTEM experiment at LHC for proton-proton cross section measurements

    CERN Document Server

    Cafagna, Francesco

    2015-01-01

    The LHC energy begins to overlap with the energy range where extreme energy cosmic-ray showers are studied. Investigations of proton-proton interactions at the LHC are therefore of high importance for the study of the development of cosmic-ray showers in the atmosphere and thus for the measurements of the high-energy cosmic-ray spectra and composition. The TOTEM (TOTal cross section, Elastic scattering and diffraction dissociation Measurement at the LHC) experiment at LHC, has been designed to measure the total proton-proton cross-section with a luminosity independent method, based on the optical theorem, and study the elastic and diffractive scattering at the LHC energy. This method relies on the capability of the simultaneous measurements of inelastic and elastic rates; in the TOTEM experiment this is possible thanks to two forward inelastic telescopes, covering the pseudorapitidy range 3.1 < |h| < 6.5, and Roman Pot detectors, that can be inserted down to few hundred microns to the beam centre. Thank...

  2. Measurement of Drug Craving in Persian Speaking Subjects; a Review on Current Experiences and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Masoomeh Maarefvand

    2012-09-01

    Full Text Available Background: Drug craving is considered as one of the main cores of drug dependency and addiction. Multidimensionality of drug craving, its cultural-bounded features and its intra individual rapidly changing nature makes it difficult to be measured. Nowadays, regarding different psychometric approaches, there are various instruments available for measurement of different aspects of drug craving but mainly for Latin-based languages in North America and European countries. High prevalence and special conditions, and unique subcultures in substance abuse and addiction in many countries, like Iran, make the design of culturally validated instruments for drug craving assessment priority. Materials and Methods: Comprehensive review on drug craving measurement instruments for Persian speaking subjects have been performed by searching in databases (ELSEVIER, Science Direct and Scientific Information Database (SID and investigating of related documents on regional experiences. Results: In this article seven main categories of drug craving instruments have been reviewed focusing on validated versions in Persian language including: self-reports, reinforcement “proxies”, drug self administration, psycho physiological responding, neurobiological responding, cognitive processing and expressive methods. Conclusion: Reviewing on weak and strength points of each instrument group and national and regional experiences shows that designing and validating a new series of ecologically-validated instruments for multidimensional measurement of drug craving in different addiction subcultures should be prioritized to cover current methodological gaps in substance abuse studies in Iran.

  3. A full Stokes vector ellipsometry measurement system for in situ diagnostics in dynamic experiments

    Science.gov (United States)

    Bakshi, L.; Eliezer, S.; Appelbaum, G.; Nissim, N.; Perelmutter, L.; Mond, M.

    2012-05-01

    A fast ellipsometry system with a resolution of only a few nanoseconds that can simultaneously measure all four Stokes parameters was developed for use in dynamic experiments. Due to its fine temporal resolution, the system is useful for a wide variety of dynamic setups, two of which are presented, fast foil heating and shock compression. As a test case the optical properties of nickel were measured in a fast foil heating setup. The complex index of refraction and emissivity at 532 nm and in the range of 1000-1900 K are presented. It was found that the emissivity monotonously increases below and above the melting point while an abrupt increase of about 2% was observed at the phase transition. These results are in accordance with the literature. Shock compression experiments included sample-free surface measurements. Samples of 1020 steel were shocked up to 25 GPa on the Hugoniot curve. The measured optical properties under these conditions showed a significant change; the value of the emissivity was doubled.

  4. Direct measurement of the top-quark width with the ATLAS experiment

    CERN Document Server

    Murillo Quijada, Javier Alberto

    In this thesis a measurement of the total decay width of the top quark, Г_{top} is presented using selected semi-leptonic {t¯t} event candidates, recorded from protonproton collisions at a centre-of-mass energy of \\sqrt{s} = 8 TeV with the ATLAS experiment at CERN in Geneva, Switzerland. The total recorded integrated luminosity that was used for this measurement equals to \\intLdt = 20.3 fb^{−1}. The analysis includes the two event channels: e + jets and μ + jets. The reconstruction of the {t¯t} system is achieved by using a per-event X2 minimisation technique. Official Monte Carlo samples have been used to simulate the t¯t signal and background contributions in order to perform simulated experiments to obtain the statistical and systematic uncertainties. The results obtained from the measurement of the top parameter are: Г_{top} = 1.65 GeV for the μ + jets channel and Г_{top} = 0.81 GeV for the e + jets channel. The upper limits obtained from the measured values and the analysis total uncertainties ...

  5. Jet measurements in proton-proton collisions with the ALICE experiment at LHC

    CERN Document Server

    Vajzer, Michal

    2013-01-01

    The study of jets, collimated sprays of particles associated with hard partons, is an important tool in testing perturbative quantum chromodynamics (pQCD) and probing hot and dense nuclear matter created in high energy heavy-ion collisions. Jets enable the study of hard scatterings, fragmentation and hadronisation and their modification in the presence of a nuclear medium with respect to baseline vacuum measurements, which is acquired from jet measurements in proton-proton collisions. We have analysed data from proton-proton collisions at s= \\sqrt{s} = 7 TeV measured by the ALICE experiment at the LHC and reconstructed the inclusive spectra of charged particle jets at mid- rapidity using anti-kT clustering algorithm. We present the jet spectra corrected for detector effects using several unfolding methods. Furthermore, we examine various properties of jets, such as their charged particle multiplicity and jet shapes.

  6. The neutral atmosphere temperature experiment. [for thermospheric nitrogen measurement on AEROS satellite

    Science.gov (United States)

    Spencer, N. W.; Pelz, D. T.; Niemann, H. B.; Carignan, G. R.; Caldwell, J. R.

    1974-01-01

    The AEROS Neutral Atmosphere Temperature Experiment (NATE) is designed to measure the kinetic temperature of molecular nitrogen in the thermosphere. A quadrupole mass spectrometer tuned to N2 measures the N2 density variation in a small spherical antechamber having a knife-edged orifice which is exposed to the atmosphere at the outer surface of the spacecraft. The changing density of N2 due to the spinning motion of the spacecraft permits determination of the velocity distribution of the N2 from which the temperature is calculated. An alternate mode of operation of the instrument allows measurement of the other gases in the atmosphere as well as N2 permitting determination of the neutral particle composition of the atmosphere.

  7. Measurement of the luminosity in the ZEUS experiment at HERA II

    Energy Technology Data Exchange (ETDEWEB)

    Adamczyk, L.; Bold, T. [AGH Univ. of Science and Technology, Cracow (Poland); Andruszkow, J. [Polish Academy of Sciences, Cracow (Poland). Inst. of Nuclear Physics] [and others

    2013-06-15

    The luminosity in the ZEUS detector was measured using photons from electron bremsstrahlung. In 2001 the HERA collider was upgraded for operation at higher luminosity. At the same time the luminosity-measuring system of the ZEUS experiment was modified to tackle the expected higher photon rate and synchrotron radiation. The existing lead-scintillator calorimeter was equipped with radiation hard scintillator tiles and shielded against synchrotron radiation. In addition, a magnetic spectrometer was installed to measure the luminosity independently using photons converted in the beam-pipe exit window. The redundancy provided a reliable and robust luminosity determination with a systematic uncertainty of 1.7%. The experimental setup, the techniques used for luminosity determination and the estimate of the systematic uncertainty are reported.

  8. Synthesis and properties of novel water-soluble fullerene-glycine derivatives as new materials for cancer therapy.

    Science.gov (United States)

    Jiang, Guichang; Yin, Fen; Duan, Jihua; Li, Guangtao

    2015-01-01

    Novel water-soluble fullerene-glycine derivatives were synthesized by means of simple organic chemistry. They are completely soluble in water, yielding a clear brown solution. The products were characterized by fourier transform infrared (FTIR), ultraviolet-visible spectroscopy (UV-Vis), (1)H NMR, (13)C NMR, thermogravimetric analyses (TGA), and scanning electron microscopy (SEM). The assembly behavior of water-soluble fullerene-glycine derivatives was investigated by SEM. The results show that the fullerene-glycine derivatives create morphology that is sphere-like. The cytotoxicity to cancer cell lines of the fullerene-glycine derivatives was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) and flow cytometry. The results show that fullerene-glycine derivatives exhibit mortality and apoptosis of the cells which increased with the increase of fullerene-glycine derivative concentration. The cytotoxicity mechanism of fullerene-glycine derivatives was investigated for the first time. Novel water-soluble fullerene-glycine derivatives were synthesized by means of simple organic chemistry. The products were characterized by FTIR, UV-Vis, (1)H NMR, (13)C NMR, TGA, and SEM. The bioactivities of fullerene-glycine derivative materials have been tested, and the results show that compared with the fullerene complex, the fullerene-glycine derivative materials exhibit mortality and apoptosis of the cells which increased with the increase of fullerene-glycine derivative concentration. SEM images showed the macrostructure of fullerene-glycine derivative materials was spheres.

  9. Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine

    Science.gov (United States)

    During pregnancy, glycine and serine become more important because they are the primary suppliers of methyl groups for the synthesis of fetal DNA, and more glycine is required for fetal collagen synthesis as pregnancy progresses. In an earlier study, we reported that glycine flux decreased by 39% fr...

  10. The Indianapolis Flux Experiment (INFLUX: A test-bed for developing urban greenhouse gas emission measurements

    Directory of Open Access Journals (Sweden)

    Kenneth J. Davis

    2017-05-01

    Full Text Available The objective of the Indianapolis Flux Experiment (INFLUX is to develop, evaluate and improve methods for measuring greenhouse gas (GHG emissions from cities. INFLUX’s scientific objectives are to quantify CO2 and CH4 emission rates at 1 km2 resolution with a 10% or better accuracy and precision, to determine whole-city emissions with similar skill, and to achieve high (weekly or finer temporal resolution at both spatial resolutions. The experiment employs atmospheric GHG measurements from both towers and aircraft, atmospheric transport observations and models, and activity-based inventory products to quantify urban GHG emissions. Multiple, independent methods for estimating urban emissions are a central facet of our experimental design. INFLUX was initiated in 2010 and measurements and analyses are ongoing. To date we have quantified urban atmospheric GHG enhancements using aircraft and towers with measurements collected over multiple years, and have estimated whole-city CO2 and CH4 emissions using aircraft and tower GHG measurements, and inventory methods. Significant differences exist across methods; these differences have not yet been resolved; research to reduce uncertainties and reconcile these differences is underway. Sectorally- and spatially-resolved flux estimates, and detection of changes of fluxes over time, are also active research topics. Major challenges include developing methods for distinguishing anthropogenic from biogenic CO2 fluxes, improving our ability to interpret atmospheric GHG measurements close to urban GHG sources and across a broader range of atmospheric stability conditions, and quantifying uncertainties in inventory data products. INFLUX data and tools are intended to serve as an open resource and test bed for future investigations. Well-documented, public archival of data and methods is under development in support of this objective.

  11. The craving experience questionnaire: a brief, theory-based measure of consummatory desire and craving.

    Science.gov (United States)

    May, Jon; Andrade, Jackie; Kavanagh, David J; Feeney, Gerald F X; Gullo, Mathew J; Statham, Dixie J; Skorka-Brown, Jessica; Connolly, Jennifer M; Cassimatis, Mandy; Young, Ross McD; Connor, Jason P

    2014-05-01

    Research into craving is hampered by lack of theoretical specification and a plethora of substance-specific measures. This study aimed to develop a generic measure of craving based on elaborated intrusion (EI) theory. Confirmatory factor analysis (CFA) examined whether a generic measure replicated the three-factor structure of the Alcohol Craving Experience (ACE) scale over different consummatory targets and time-frames. Twelve studies were pooled for CFA. Targets included alcohol, cigarettes, chocolate and food. Focal periods varied from the present moment to the previous week. Separate analyses were conducted for strength and frequency forms. Nine studies included university students, with single studies drawn from an internet survey, a community sample of smokers and alcohol-dependent out-patients. A heterogeneous sample of 1230 participants. Adaptations of the ACE questionnaire. Both craving strength [comparative fit indices (CFI = 0.974; root mean square error of approximation (RMSEA) = 0.039, 95% confidence interval (CI) = 0.035-0.044] and frequency (CFI = 0.971, RMSEA = 0.049, 95% CI = 0.044-0.055) gave an acceptable three-factor solution across desired targets that mapped onto the structure of the original ACE (intensity, imagery, intrusiveness), after removing an item, re-allocating another and taking intercorrelated error terms into account. Similar structures were obtained across time-frames and targets. Preliminary validity data on the resulting 10-item Craving Experience Questionnaire (CEQ) for cigarettes and alcohol were strong. The Craving Experience Questionnaire (CEQ) is a brief, conceptually grounded and psychometrically sound measure of desires. It demonstrates a consistent factor structure across a range of consummatory targets in both laboratory and clinical contexts. © 2014 Society for the Study of Addiction.

  12. Experience with novel technologies for direct measurement of atmospheric NO2

    Science.gov (United States)

    Hueglin, Christoph; Hundt, Morten; Mueller, Michael; Schwarzenbach, Beat; Tuzson, Bela; Emmenegger, Lukas

    2017-04-01

    Nitrogen dioxide (NO2) is an air pollutant that has a large impact on human health and ecosystems, and it plays a key role in the formation of ozone and secondary particulate matter. Consequently, legal limit values for NO2 are set in the EU and elsewhere, and atmospheric observation networks typically include NO2 in their measurement programmes. Atmospheric NO2 is principally measured by chemiluminescence detection, an indirect measurement technique that requires conversion of NO2 into nitrogen monoxide (NO) and finally calculation of NO2 from the difference between total nitrogen oxides (NOx) and NO. Consequently, NO2 measurements with the chemiluminescence method have a relatively high measurement uncertainty and can be biased depending on the selectivity of the applied NO2 conversion method. In the past years, technologies for direct and selective measurement of NO2 have become available, e.g. cavity attenuated phase shift spectroscopy (CAPS), cavity enhanced laser absorption spectroscopy and quantum cascade laser absorption spectrometry (QCLAS). These technologies offer clear advantages over the indirect chemiluminescence method. We tested the above mentioned direct measurement techniques for NO2 over extended time periods at atmospheric measurement stations and report on our experience including comparisons with co-located chemiluminescence instruments equipped with molybdenum as well as photolytic NO2 converters. A still open issue related to the direct measurement of NO2 is instrument calibration. Accurate and traceable reference standards and NO2 calibration gases are needed. We present results from the application of different calibration strategies based on the use of static NO2 calibration gases as well as dynamic NO2 calibration gases produced by permeation and by gas-phase titration (GPT).

  13. Development and evaluation of the children's experiences of dental anxiety measure.

    Science.gov (United States)

    Porritt, Jenny; Morgan, Annie; Rodd, Helen; Gupta, Ekta; Gilchrist, Fiona; Baker, Sarah; Newton, Tim; Creswell, Cathy; Williams, Christopher; Marshman, Zoe

    2018-03-01

    Existing measures of children's dental anxiety have not been developed with children or based on a theoretical framework of dental anxiety. To develop the children's experiences of dental anxiety measure (CEDAM) and evaluate the measure's properties. The measure was developed from interviews with dentally anxious children. Children recruited from a dental hospital and secondary school completed the CEDAM and Modified Child Dental Anxiety Scale (MCDAS). A subgroup of children completed the CEDAM before and after receiving an intervention to reduce dental anxiety to examine the measure's responsiveness. Rasch and Classical test analyses were undertaken. Children were aged between 9 and 16 years (N = 88 recruited from a dental hospital and N = 159 recruited from a school). Rasch analysis confirmed the measure's unidimensionality. The CEDAM correlated well with the MCDAS (rho = 0.67, P dental anxiety following the intervention (baseline mean = 22.36, SD = 2.57 and follow-up mean = 18.88, SD = 2.42, t(df = 37) = 9.54, P dental anxiety. © 2017 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Modeling and design of radiative hydrodynamic experiments with X-ray Thomson Scattering measurements on NIF

    Science.gov (United States)

    Ma, K. H.; Lefevre, H. J.; Belancourt, P. X.; MacDonald, M. J.; Doeppner, T.; Keiter, P. A.; Kuranz, C. C.; Johnsen, E.

    2017-10-01

    Recent experiments at the National Ignition Facility studied the effect of radiation on shock-driven hydrodynamic instability growth. X-ray radiography images from these experiments indicate that perturbation growth is lower in highly radiative shocks compared to shocks with negligible radiation flux. The reduction in instability growth is attributed to ablation from higher temperatures in the foam for highly radiative shocks. The proposed design implements the X-ray Thomson Scattering (XRTS) technique in the radiative shock tube platform to measure electron temperatures and densities in the shocked foam. We model these experiments with CRASH, an Eulerian radiation hydrodynamics code with block-adaptive mesh refinement, multi-group radiation transport and electron heat conduction. Simulations are presented with SiO2 and carbon foams for both the high temperature, radiative shock and the low-temperature, hydrodynamic shock cases. Calculations from CRASH give estimations for shock speed, electron temperature, effective ionization, and other quantities necessary for designing the XRTS diagnostic measurement. This work is funded by the LLNL under subcontract B614207, and was performed under the auspices of the U.S. DOE by LLNL under Contract No. DE-AC52-07NA27344.

  15. Results of the Fluid Merging Viscosity Measurement International Space Station Experiment

    Science.gov (United States)

    Ethridge, Edwin C.; Kaukler, William; Antar, Basil

    2009-01-01

    The purpose of FMVM is to measure the rate of coalescence of two highly viscous liquid drops and correlate the results with the liquid viscosity and surface tension. The experiment takes advantage of the low gravitational free floating conditions in space to permit the unconstrained coalescence of two nearly spherical drops. The merging of the drops is accomplished by deploying them from a syringe and suspending them on Nomex threads followed by the astronaut s manipulation of one of the drops toward a stationary droplet till contact is achieved. Coalescence and merging occurs due to shape relaxation and reduction of surface energy, being resisted by the viscous drag within the liquid. Experiments were conducted onboard the International Space Station in July of 2004 and subsequently in May of 2005. The coalescence was recorded on video and down-linked near real-time. When the coefficient of surface tension for the liquid is known, the increase in contact radius can be used to determine the coefficient of viscosity for that liquid. The viscosity is determined by fitting the experimental speed to theoretically calculated contact radius speed for the same experimental parameters. Recent fluid dynamical numerical simulations of the coalescence process will be presented. The results are important for a better understanding of the coalescence process. The experiment is also relevant to liquid phase sintering, free form in-situ fabrication, and as a potential new method for measuring the viscosity of viscous glass formers at low shear rates.

  16. AEgIS experiment: Towards antihydrogen beam production for antimatter gravity measurements

    CERN Document Server

    Mariazzi, Sebastiano; Amsler, Claude; Ariga, Akitaka; Ariga, Tomoko; Belov, Alexandre S; Bonomi, Germano; Bräunig, Philippe; Brusa, Roberto S; Bremer, Johan; Cabaret, Louis; Canali, Carlo; Caravita, Ruggero; Castelli, Fabrizio; Cerchiari, Giovanni; Cialdi, Simone; Comparat, Daniel; Consolati, Giovanni; Dassa, Luca; Derking, Jan Hendrik; Di Domizio, Sergio; Di Noto, Lea; Doser, Michael; Dudarev, Alexey; Ereditato, Antonio; Ferragut, Rafael; Fontana, Andrea; Genova, Pablo; Giammarchi, Marco; Gligorova, Angela; Gninenko, Sergei N; Hogan, Stephen D; Haider, Stefan; Jordan, Elena; Jørgensen, Lars V; Kaltenbacher, Thomas; Kawada, Jiro; Kellerbauer, Alban; Kimura, Mitsuhiro; Knecht, Andreas; Krasnický, Daniel; Lagomarsino, Vittorio; Lehner, Sebastian; Malbrunot, Chloe; Matveev, Viktor A; Merkt, Frederic; Moia, Fabio; Nebbia, Giancarlo; Nédélec, Patrick; Oberthaler, Markus K; Pacifico, Nicola; Petráček, Vojtech; Pistillo, Ciro; Prelz, Francesco; Prevedelli, Marco; Regenfus, Christian; Riccardi, Cristina; Røhne, Ole; Rotondi, Alberto; Sandaker, Heidi; Scampoli, Paola; Storey, James; Subieta Vasquez, Martin A.; Spaček, Michal; Czech Technical U. in Prague - FNSPE - B\\oehova 7 - 11519 - Praha 1 - Czech Aff25 Testera, Gemma; Vaccarone, Renzo; Villa, Fabio; Widmann, Eberhard; Zavatarelli, Sandra; Zmeskal, Johann

    2014-01-01

    AEgIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) is an experiment that aims to perform the first direct measurement of the gravitational acceleration g of antihydrogen in the Earth’s field. A cold antihydrogen beam will be produced by charge exchange reaction between cold antiprotons and positronium excited in Rydberg states. Rydberg positronium (with quantum number n between 20 and 30) will be produced by a two steps laser excitation. The antihydrogen beam, after being accelerated by Stark effect, will fly through the gratings of a moir ́ e deflectometer. The deflection of the horizontal beam due to its free fall will be measured by a position sensitive detector. It is estimated that the detection of about 10 3 antihydrogen atoms is required to determine the gravitational acceleration with a precision of 1%. In this report an overview of the AEgIS experiment is presented and its current status is described. Details on the production of slow positronium and its excitation with lasers ar...

  17. Effect of ions on the measurement of sulphuric acid in the CLOUD experiment at CERN

    CERN Document Server

    Rondo, L; Ehrhart, S; Schobesberger, S; Franchin, A; Junninen, H; Petäjä, T; Sipilä, M; Worsnop, D R; Curtius, J

    2014-01-01

    Ternary aerosol nucleation experiments were conducted in the CLOUD chamber at CERN in order to investigate the influence of ions on new particle formation. Neutral and ion-induced nucleation experiments, i.e., with and without the presence of ions, were carried out under precisely controlled conditions. The sulphuric acid concentration was measured with a Chemical Ionization Mass Spectrometer (CIMS) during the new particle formation experiments. The added ternary trace gases were ammonia (NH3), dimethylamine (DMA, C2H7N) or oxidised products of pinanediol (PD, C10H18O2). When pinanediol was introduced into the chamber, an increase in the mass spectrometric signal used to determine the sulphuric acid concentration (m/z 97, i.e., HSO4−) was observed due to ions from the CLOUD chamber. The enhancement was only observed during ion-induced nucleation measurements by using either galactic cosmic rays (GCR) or the proton synchrotron (PS) pion beam for the ion generation, respectively. The ion effect typically invo...

  18. Measurements of $B \\to \\mu^{+} \\mu^{-}$ decays using the LHCb experiment

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00400160

    This dissertation documents a study of very rare $B$-meson decays at the LHCb experiment, using data taken during the first experiment run of the Large Hadron Collider (LHC) and during the second experiment run until September 2016. The LHCb experiment was designed to test the Standard Model of particle physics and to search for New Physics effects that go beyond the scope of the Standard Model through the decay of $b$ hadrons produced in high energy proton-proton collisions at the LHC. The measurements described in this dissertation are made using data samples of proton-proton collisions with integrated luminosities of 1.0, 2.0 and 1.4 fb$^{-1}$, collected at centre-of-mass energies of 7, 8 and 13 TeV, respectively. The branching fractions of the very rare $B^{0} \\to \\mu^{+} \\mu^{-}$ and $B_{s}^{0} \\to \\mu^{+} \\mu^{-}$ decays and the effective lifetime of $B_{s}^{0} \\to \\mu^{+} \\mu^{-}$ decays are precisely predicted by the Standard Model and are sensitive to effects from New Physics. New Physics processes...

  19. Proteome data associated with the leaf senescence in Glycine max

    Directory of Open Access Journals (Sweden)

    Ravi Gupta

    2016-12-01

    Full Text Available The data presented in this article are associated with the article “Coupling of gel-based 2-DE and 1-DE shotgun proteomics approaches to dig deep into the leaf senescence proteome of Glycine max” (R. Gupta, S.J. Lee, C.W. Min, S.W. Kim, K.-H. Park, D.-W. Bae, et al., 2016 [1]. Leaf senescence is one of the important aspects of the life cycle of a plant that leads to the recycling of nutrients from source to sink cells. To understand the leaf senescence-associated proteins, we used a combination of gel-based 2-DE and 1-DE shotgun proteomic approaches. Here, we display the 2-DE, Mass spectrometry, and Gene ontology data related with the leaf senescence in soybean [1].

  20. Glycine transporter dimers: evidence for occurrence in the plasma membrane

    DEFF Research Database (Denmark)

    Bartholomäus, Ingo; Milan-Lobo, Laura; Nicke, Annette

    2008-01-01

    membrane based on hydrodynamic and native gel electrophoretic studies. Here, we used cysteine substitution and oxidative cross-linking to show that of GlyT1 and GlyT2 also form dimeric complexes within the plasma membrane. GlyT oligomerization at the cell surface was confirmed for both GlyT1 and GlyT2......Different Na(+)/Cl(-)-dependent neurotransmitter transporters of the SLC6a family have been shown to form dimers or oligomers in both intracellular compartments and at the cell surface. In contrast, the glycine transporters (GlyTs) GlyT1 and -2 have been reported to exist as monomers in the plasma...

  1. Modulation of gephyrin-glycine receptor affinity by multivalency

    DEFF Research Database (Denmark)

    Maric, Hans-Michael; Kasaragod, Vikram Babu; Schindelin, Hermann

    2014-01-01

    Gephyrin is a major determinant for the accumulation and anchoring of glycine receptors (GlyRs) and the majority of γ-aminobutyric acid type A receptors (GABAARs) at postsynaptic sites. Here we explored the interaction of gephyrin with a dimeric form of a GlyR β-subunit receptor-derived peptide......, and isothermal titration calorimetry (ITC) demonstrated that this dimeric ligand is capable of binding simultaneously to two receptor binding sites and that this multivalency results in a 25-fold enhanced affinity. Our study therefore suggests that the oligomeric state of gephyrin and the number of gephyrin......-binding subunits in the pentameric GABAARs and GlyRs together control postsynaptic receptor clustering....

  2. Bioactivities of Novel Metal Complexes Involving B Vitamins and Glycine

    Directory of Open Access Journals (Sweden)

    Fazary Ahmed E.

    2016-01-01

    Full Text Available In this work twelve novel mixed ligand complexes were synthesized. The complexes were formed between a metal ion (Cu(II, Cd(II, Mn(II, Fe(III, Ni(II, Pb(II and vitamins (B 3 and B 9 as primary ligands, and glycine as secondary ligand. Melting points, conductivities, and magnetic susceptibilities of the synthesized complexes were determined and the complexes were subjected to elemental analyses. The presence of coordination water molecules in the complex was also supported by TG/DTG thermal analysis. Full elucidation of the molecular structures for the synthesized mixed ligand complexes were confirmed using detailed spectroscopic IR, 1H-, 13C-NMR, and XRD techniques. In addition, cytotoxic and antioxidant activities of the twelve synthesized solid complexes were tested to evaluate their bioactivities.

  3. Thermal effects of carbonated hydroxyapatite modified by glycine and albumin

    Science.gov (United States)

    Gerk, S. A.; Golovanova, O. A.; Kuimova, M. V.

    2017-01-01

    In this work calcium phosphate powders were obtained by precipitation method from simulated solutions of synovial fluid containing glycine and albumin. X-ray diffraction and IR spectroscopy determined that all samples are single-phase and are presented by carbonate containing hydroxyapatite (CHA). The thermograms of solid phases of CHA were obtained and analyzed; five stages of transformation in the temperature range of 25-1000°C were marked. It is shown that in this temperature range dehydration, decarboxylation and thermal degradation of amino acid and protein connected to the surface of solid phase occur. The tendency of temperature lowering of the decomposition of powders synthesized from a medium containing organic substances was determined. Results demonstrate a direct dependence between the concentration of the amino acid in a model solution and its content in the solid phase.

  4. Arctic (and Antarctic) Observing Experiment - an Assessment of Methods to Measure Temperature over Polar Environments

    Science.gov (United States)

    Rigor, I. G.; Clemente-Colon, P.; Nghiem, S. V.; Hall, D. K.; Woods, J. E.; Henderson, G. R.; Zook, J.; Marshall, C.; Gallage, C.

    2014-12-01

    The Arctic environment has been undergoing profound changes; the most visible is the dramatic decrease in Arctic sea ice extent (SIE). These changes pose a challenge to our ability to measure surface temperature across the Polar Regions. Traditionally, the International Arctic Buoy Programme (IABP) and International Programme for Antarctic Buoys (IPAB) have measured surface air temperature (SAT) at 2-m height, which minimizes the ambiguity of measurements near of the surface. Specifically, is the temperature sensor measuring open water, snow, sea ice, or air? But now, with the dramatic decrease in Arctic SIE, increase in open water during summer, and the frailty of the younger sea ice pack, the IABP has had to deploy and develop new instruments to measure temperature. These instruments include Surface Velocity Program (SVP) buoys, which are commonly deployed on the world's ice-free oceans and typically measure sea surface temperature (SST), and the new robust Airborne eXpendable Ice Beacons (AXIB), which measure both SST and SAT. "Best Practice" requires that these instruments are inter-compared, and early results showing differences in collocated temperature measurements of over 2°C prompted the establishment of the IABP Arctic Observing Experiment (AOX) buoy test site at the US Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) site in Barrow, Alaska. Preliminary results showed that the color of the hull of SVP buoys introduces a bias due to solar heating of the buoy. Since then, we have recommended that buoys should be painted white to reduce biases in temperature measurements due to different colors of the buoys deployed in different regions of the Arctic or the Antarctic. Measurements of SAT are more robust, but some of the temperature shields are susceptible to frosting. During our presentation we will provide an intercomparison of the temperature measurements at the AOX test site (i.e. high quality DOE/ARM observations compared with

  5. Dietary supplementation of glycine modulates inflammatory response indicators in broiler chickens.

    Science.gov (United States)

    Takahashi, Kazuaki; Aoki, Akira; Takimoto, Testuya; Akiba, Yukio

    2008-11-01

    Three experiments were conducted to investigate the effect of dietary glycine (Gly) supplementation on inflammatory responses in broiler chicks fed a basal diet using maize and soybean meal as the primary ingredients. Inflammation-related processes following lipopolysaccharide (LPS) injection were examined by analysing plasma concentrations of nitrate plus nitrite (NOx) and ceruloplasmin (Cer) in experiments 1 and 2, or expression of several genes in the spleen and liver including IL-1 beta and -6, TNF-like ligand (TL)1A, inducible NO synthase, interferon (IFN)-gamma and toll-like receptor (TLR) 4 were examined in experiment 3. Growth performance was also determined following immunological stimulation by both LPS and Sephadex injection in experiment 2. In experiment 1, birds fed a diet supplemented with Gly at 10 or 20 g/kg showed lower responses in plasma NOx and Cer than birds fed the diet supplemented with Gly at 0 or 40 g/kg. In experiment 2, a similar effect of Gly supplementation at 10 g/kg on plasma NOx and Cer was observed when chicks were fed either an isonitrogenous diet with Gly or glutamic acid (Glu). Gly-supplemented diet-fed birds showed better growth performance than Glu-supplemented diet-fed birds. The splenic expression of inflammatory response-related genes in birds fed a diet supplemented with Gly at 10 g/kg diet was lower than that of birds fed the basal diet in experiment 3. These results suggest that dietary Gly supplementation modulates the inflammatory response partly through changes in the expression of pro-inflammatory cytokines such as IL-1, IL-6, IFN-gamma and TL1A.

  6. Reduction of glycine particle size by impinging jet crystallization.

    Science.gov (United States)

    Tari, Tímea; Fekete, Zoltán; Szabó-Révész, Piroska; Aigner, Zoltán

    2015-01-15

    The parameters of crystallization processes determine the habit and particle size distribution of the products. A narrow particle size distribution and a small average particle size are crucial for the bioavailability of poorly water-soluble pharmacons. Thus, particle size reduction is often required during crystallization processes. Impinging jet crystallization is a method that results in a product with a reduced particle size due to the homogeneous and high degree of supersaturation at the impingement point. In this work, the applicability of the impinging jet technique as a new approach in crystallization was investigated for the antisolvent crystallization of glycine. A factorial design was applied to choose the relevant crystallization factors. The results were analysed by means of a statistical program. The particle size distribution of the crystallized products was investigated with a laser diffraction particle size analyser. The roundness and morphology were determined with the use of a light microscopic image analysis system and a scanning electron microscope. Polymorphism was characterized by differential scanning calorimetry and powder X-ray diffraction. Headspace gas chromatography was utilized to determine the residual solvent content. Impinging jet crystallization proved to reduce the particle size of glycine. The particle size distribution was appropriate, and the average particle size was an order of magnitude smaller (d(0.5)=8-35 μm) than that achieved with conventional crystallization (d(0.5)=82-680 μm). The polymorphic forms of the products were influenced by the solvent ratio. The quantity of residual solvent in the crystallized products was in compliance with the requirements of the International Conference on Harmonization. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Two experiments for the measurement of the centre of percussion of a physical pendulum

    Science.gov (United States)

    Malgieri, Massimiliano; Onorato, Pasquale; Mascheretti, Paolo; De Ambrosis, Anna

    2016-09-01

    In this article we describe two experiments, performed with instrumentation commonly available in undergraduate laboratories, to measure the position of the centre of percussion of a physical pendulum. The first one makes use of a constant external force provided by a common spring dynamometer, and allows for a straightforward analysis founded on basic concepts of rigid body dynamics. The second one is, more properly, an experiment based on a percussion, i.e. a collision involving an almost impulsive force, and displays the typical difficulties, but also the physical richness, of this type of phenomena. We provide an historical overview of the problem of the centre of percussion, starting from its first formulation given by Bernardino Baldi at the end of the 16th century, and we show how the mathematical model built for analysing the impact between a physical pendulum and a localised object is helpful in understanding that such a problem, in its original formulation, does not have a unique answer.

  8. Consequences of recent loophole-free experiments on a relaxation of measurement independence

    Science.gov (United States)

    Hnilo, Alejandro A.

    2017-02-01

    Recent experiments using innovative optical detectors and techniques have strongly increased the capacity of testing the violation of the Bell's inequalities in Nature. Most of them have used the Eberhard's inequality (EI) to close the "detection" loophole. Closing the "locality" loophole has been attempted by spacelike separated detections and fast changes of the bases of observation, driven by random number generators of new design. Also, pulsed pumping and time-resolved data recording to close the "time-coincidence" loophole, and sophisticated statistical methods to close the "memory" loophole, have been used. In this paper, the meaning of the EI is reviewed. A simple hidden variables theory based on a relaxation of the condition of "measurement independence," which was devised long ago for the Clauser-Horne-Shimony and Holt inequality, is adapted to the EI case. It is used here to evaluate the significance of the results of the recent experiments, which are briefly described. A table summarizes the main results.

  9. Fluence measurement at the neutron time of flight experiment at CERN

    CERN Document Server

    Weiss, Christina; Jericha, Erwin

    At the neutron time of flight facility n_TOF at CERN a new spallation target was installed in 2008. In 2008 and 2009 the commissioning of the new target took place. During the summer 2009 a fission chamber of the Physikalisch Technische Bundesanstalt (PTB) Braunschweig was used for the neutron fluence measurement. The evaluation of the data recorded with this detector is the primary topic of this thesis. Additionally a neutron transmission experiment with air has been performed at the TRIGA Mark II reactor of the Atomic Institute of the Austrian Universities (ATI). The experiment was implemented to clarify a question about the scattering cross section of molecular gas which could not be answered clearly via the literature. This problem came up during the evaluations for n_TOF.

  10. Impact of legal measures prevent transplant tourism: the interrelated experience of The Philippines and Israel.

    Science.gov (United States)

    Padilla, Benita; Danovitch, Gabriel M; Lavee, Jacob

    2013-11-01

    We describe the parallel changes that have taken place in recent years in two countries, Israel and The Philippines, the former once an "exporter" of transplant tourists and the latter once an "importer" of transplant tourists. These changes were in response to progressive legislation in both countries under the influence of the Declaration of Istanbul. The annual number of Israeli patients who underwent kidney transplantation abroad decreased from a peak of 155 in 2006 to an all-time low of 35 in 2011 while in the Philippines the annual number of foreign transplant recipients fell from 531 in 2007 to two in 2011. The experience of these two countries provides a "natural experiment" on the potential impact of legal measures to prevent transplant tourism.

  11. On the impact of systematical uncertainties for the CP violation measurement in superbeam experiments

    CERN Document Server

    Huber, Patrick; Schwetz, Thomas

    2008-01-01

    Superbeam experiments can, in principle, achieve impressive sensitivities for CP violation in neutrino oscillations for large $\\theta_{13}$. We study how those sensitivities depend on assumptions about systematical uncertainties. We focus on the second phase of T2K, the so-called T2HK experiment, and we explicitly include a near detector in the analysis. Our main result is that even an idealised near detector cannot remove the dependence on systematical uncertainties completely. Thus additional information is required. We identify certain combinations of uncertainties, which are the key to improve the sensitivity to CP violation, for example the ratio of electron to muon neutrino cross sections and efficiencies. For uncertainties on this ratio larger than 2%, T2HK is systematics dominated. We briefly discuss how our results apply to a possible two far detector configuration, called T2KK. We do not find a significant advantage with respect to the reduction of systematical errors for the measurement of CP viola...

  12. ASPI experiment: measurements of fields and waves on board the INTERBALL-1 spacecraft

    Directory of Open Access Journals (Sweden)

    S. Klimov

    1997-05-01

    Full Text Available The plasma-wave experiment ASPI (analysis of spectra of plasma waves and instabilities on board the INTERBALL spacecraft is a combined wave diagnostics experiment. It performs measurements of the DC and AC magnetic field vector by flux-gate and search-coil sensors, the DC and AC electric field vector by Langmuir double probes and the plasma current by Langmuir split probe. Preliminary data analysis shows the low noise levels of the sensors and the compatibility of new data with the results of previous missions. During several months of in-orbit operation a rich collection of data was acquired, examples of which at the magnetopause and plasma sheet are presented in second part of the paper.

  13. LHC Optics Determination with Proton Tracks Measured in the Roman Pots Detectors of the TOTEM Experiment

    CERN Document Server

    Nemes, F.; Burkhardt, H.

    2012-01-01

    The TOTEM experiment at the LHC is equipped with near beam movable devices – called Roman Pots (RP) – which detect protons scattered at the interaction point (IP5) arriving to the detectors through the magnet lattice of the LHC. Proton kinematics at IP5 is reconstructed from positions and angles measured by the RP detectors, on the basis of the transport matrix between IP5 and the RP locations. The precision of optics determination is therefore of the key importance for the experiment. TOTEM developed a novel method of machine optics determination making use of angle-position distributions of elastically scattered protons observed in the RP detectors together with the data retrieved from several machine databases. The method has been successfully applied to the data samples registered in 2010 and 2011. The studies show that the transport matrix could be estimated with a precision better than 1%.

  14. Associations Between Physician Empathy, Physician Characteristics, and Standardized Measures of Patient Experience.

    Science.gov (United States)

    Chaitoff, Alexander; Sun, Bob; Windover, Amy; Bokar, Daniel; Featherall, Joseph; Rothberg, Michael B; Misra-Hebert, Anita D

    2017-10-01

    To identify correlates of physician empathy and determine whether physician empathy is related to standardized measures of patient experience. Demographic, professional, and empathy data were collected during 2013-2015 from Cleveland Clinic Health System physicians prior to participation in mandatory communication skills training. Empathy was assessed using the Jefferson Scale of Empathy. Data were also collected for seven measures (six provider communication items and overall provider rating) from the visit-specific and 12-month Consumer Assessment of Healthcare Providers and Systems Clinician and Group (CG-CAHPS) surveys. Associations between empathy and provider characteristics were assessed by linear regression, ANOVA, or a nonparametric equivalent. Significant predictors were included in a multivariable linear regression model. Correlations between empathy and CG-CAHPS scores were assessed using Spearman rank correlation coefficients. In bivariable analysis (n = 847 physicians), female sex (P empathy scores. In multivariable analysis, female sex (P empathy scores. Of the seven CG-CAHPS measures, scores on five for the 583 physicians with visit-specific data and on three for the 277 physicians with 12-month data were positively correlated with empathy. Specialty and sex were independently associated with physician empathy. Empathy was correlated with higher scores on multiple CG-CAHPS items, suggesting improving physician empathy might play a role in improving patient experience.

  15. Beyond standard quality of life measures: the subjective experiences of living with inflammatory bowel disease.

    Science.gov (United States)

    Wolfe, Barat J; Sirois, Fuschia M

    2008-08-01

    In order to facilitate our understanding of health-related quality of life (HRQoL) for inflammatory bowel disease (IBD) patients, it is critical to explore their subjective experiences with the disease. Research has suggested that current modes of assessing HRQoL (i.e., generic and disease-specific measures) may not fully represent all dimensions of patients' HRQoL. The purpose of this study was to examine IBD patients' subjective experiences of the daily impact of IBD, and categorize dimensions of their HRQoL affected by IBD, as identified by the patients themselves. Two hundred and eighty-two patients with IBD provided answers to the qualitative question "How has IBD affected your daily activities?" A content analysis using NVivo 2.0 was conducted on the participants' responses to this question to reveal dimensions of their HRQoL. The analysis yielded six dimensions and several subdimensions of HRQoL, including physical (systemic functioning, daily functioning, energy/vitality, pain), emotional, social, cognitive (functioning, attending to disease), self-regulation (taking control, loss of control, and neutral), and practical functioning. These results reflect previous findings, but also reveal several dimensions of HRQoL not included in current measures of HRQoL for IBD patients (i.e., cognitive, self-regulation, and practical). The implications of these findings for future measurement of HRQoL and research with IBD patients are discussed.

  16. Measurement of Compton scattering cross section during PrimEx-II Experiment at Jefferson Lab

    Science.gov (United States)

    Ye, Li; PrimEx Collaboration

    2017-09-01

    The electron Compton scattering is the most known fundamental QED process, however, a precision measurement of its cross section for the beam energy above 1 GeV has been lacking up to now. An updated high precision measurement of the neutral pion lifetime via the Primakoff effect (PrimEx-II) experiment was performed in Hall B of Jefferson Lab in 2010. The experiment used small angle coherent photoproduction of π0's in the Coulomb field of a nucleus, i.e. the Primakoff effect, to determine the lifetime with a precision of less than 1.5 % . It therefore requires thorough understanding of the underlying systematic uncertainties. To facilitate that data for well known electromagnetic processes were taken concurrently with the photoproduction data. This analysis pertains to measuring the Compton scattering cross section, which occurs at similar kinematics as the primary process. The combination of the well established theory of this process with large collected statistics allowed to extract this cross section with high precision in an energy region of 4-5 GeV for 12C and 28Si targets. The results of this analysis will be presented. This work is supported in part by the U.S. Department of Energy under Contacts No. DE-FG02-03ER41528, NSF MRI PHY-0079840, Thomas Jefferson National Laboratory, Mississippi State University and PrimEx collaboration.

  17. Measuring the continuum of literacy skills among adults: educational testing and the LAMP experience

    Science.gov (United States)

    Guadalupe, Cesar; Cardoso, Manuel

    2011-08-01

    The field of educational testing has become increasingly important for providing different stakeholders and decision-makers with information. This paper discusses basic standards for methodological approaches used in measuring literacy skills among adults. The authors address the increasing interest in skills measurement, the discourses on how this should be done with scientific integrity and UNESCO's experience regarding the Literacy Assessment and Monitoring Programme (LAMP). The increase in interest is due to the evolving notion of literacy as a continuum. Its recognition in surveys and data collection is ensured in the first commitment in section 11 of the Belém Framework for Action. The discourse on how measurements should be carried out concerns the need to find valid parsimonious approaches, also their relevance in different institutional, cultural and linguistic contexts as well as issues of ownership and sustainability. Finally, UNESCO's experience with LAMP shows how important addressing these different issues is in order to equip countries with an approach that is fit for purpose.

  18. Characterization of a CLYC detector and validation of the Monte Carlo Simulation by measurement experiments

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Suk; Ye, Sung Joon [Seoul National University, Seoul (Korea, Republic of); Smith, Martin B.; Koslowsky, Martin R. [Bubble Technology Industries Inc., Chalk River (Canada); Kwak, Sung Woo [Korea Institute of Nuclear Nonproliferation And Control (KINAC), Daejeon (Korea, Republic of); Kim Gee Hyun [Sejong University, Seoul (Korea, Republic of)

    2017-03-15

    Simultaneous detection of neutrons and gamma rays have become much more practicable, by taking advantage of good gamma-ray discrimination properties using pulse shape discrimination (PSD) technique. Recently, we introduced a commercial CLYC system in Korea, and performed an initial characterization and simulation studies for the CLYC detector system to provide references for the future implementation of the dual-mode scintillator system in various studies and applications. We evaluated a CLYC detector with 95% 6Li enrichment using various gamma-ray sources and a 252Cf neutron source, with validation of our Monte Carlo simulation results via measurement experiments. Absolute full-energy peak efficiency values were calculated for gamma-ray sources and neutron source using MCNP6 and compared with measurement experiments of the calibration sources. In addition, behavioral characteristics of neutrons were validated by comparing simulations and experiments on neutron moderation with various polyethylene (PE) moderator thicknesses. Both results showed good agreements in overall characteristics of the gamma and neutron detection efficiencies, with consistent ⁓20% discrepancy. Furthermore, moderation of neutrons emitted from {sup 252}Cf showed similarities between the simulation and the experiment, in terms of their relative ratios depending on the thickness of the PE moderator. A CLYC detector system was characterized for its energy resolution and detection efficiency, and Monte Carlo simulations on the detector system was validated experimentally. Validation of the simulation results in overall trend of the CLYC detector behavior will provide the fundamental basis and validity of follow-up Monte Carlo simulation studies for the development of our dual-particle imager using a rotational modulation collimator.

  19. A Simple Experiment to Determine the Characteristics of an NTC Thermistor for Low-Temperature Measurement Applications

    Science.gov (United States)

    Mawire, A.

    2012-01-01

    A simple low-cost experiment for undergraduate students to determine the characteristics of a negative temperature coefficient of resistance thermistor is presented. The experiment measures the resistance-temperature and voltage-temperature characteristics of the thermistor. Results of the resistance-temperature experiment are used to determine…

  20. Multi-fiber strains measured by micro-Raman spectroscopy: Principles and experiments

    Science.gov (United States)

    Lei, Zhenkun; Wang, Yunfeng; Qin, Fuyong; Qiu, Wei; Bai, Ruixiang; Chen, Xiaogang

    2016-02-01

    Based on widely used axial strain measurement method of Kevlar single fiber, an original theoretical model and measurement principle of application of micro-Raman spectroscopy to multi-fiber strains in a fiber bundle were established. The relationship between the nominal Raman shift of fiber bundle and the multi-fiber strains was deduced. The proposed principle for multi-fiber strains measurement is consistent with two special cases: single fiber deformation and multi-fiber deformation under equal strain. It is found experimentally that the distribution of Raman scattering intensity of a Kevlar 49 fiber as a function of distance between a fiber and the laser spot center follows a Gaussian function. Combining the Raman-shift/strain relationship of the Kevlar 49 single fiber and the uniaxial tension measured by micro-Raman spectroscopy, the Raman shift as a function of strain was obtained. Then the Raman peak at 1610 cm-1 for the Kevlar 49 fiber was fitted to a Lorentzian function and the FWHM showed a quadratic increase with the fiber strain. Finally, a dual-fiber tensile experiment was performed to verify the adequacy of the Raman technique for the measurement of multi-fiber strains.

  1. Measurements of Plasma Power Losses in the C-2 Field-Reversed Configuration Experiment

    Science.gov (United States)

    Korepanov, Sergey; Smirnov, Artem; Garate, Eusebio; Donin, Alexandr; Kondakov, Alexey; Singatulin, Shavkat

    2013-10-01

    A high-confinement operating regime with plasma lifetimes significantly exceeding past empirical scaling laws was recently obtained by combining plasma gun edge biasing and tangential Neutral Beam Injection in the C-2 field-reversed configuration (FRC) experiment. To analyze the power balance in C-2, two new diagnostic instruments - the pyroelectric (PE) and infrared (IR) bolometers - were developed. The PE bolometer, designed to operate in the incident power density range from 0.1-100 W/cm2, is used to measure the radial power loss, which is dominated by charge-exchange neutrals and radiation. The IR bolometer, which measures power irradiated onto a thin metal foil inserted in the plasma, is designed for the power density range from 0.5-5 kW/cm2. The IR bolometer is used to measure the axial power loss from the plasma near the end divertors. The maximum measurable pulse duration of ~ 10 ms is limited by the heat capacitance of the IR detector. Both detectors have time resolution of about 10-100 μs and were calibrated in absolute units using a high power neutral beam. We present the results of first direct measurements of axial and radial plasma power losses in C-2.

  2. Ten years of measurements from the Atmospheric Chemistry Experiment Satellite Mission

    Science.gov (United States)

    Walker, Kaley; McElroy, C. Thomas; Bernath, Peter F.; Boone, Chris

    Recently, the Canadian-led Atmospheric Chemistry Experiment (ACE) satellite mission has completed a decade of measurements from orbit. This Canadian-led scientific satellite uses infrared and UV-visible spectroscopy to investigate the chemistry and dynamics of the Earth's atmosphere. The primary instrument on-board, the ACE Fourier Transform Spectrometer (ACE-FTS) is a high-resolution (0.02 cm (-1) ) FTS operating between 750 and 4400 cm (-1) . It also contains two filtered imagers (0.525 and 1.02 microns) to measure atmospheric extinction due to clouds and aerosols. The second instrument is a dual UV-visible-NIR spectrophotometer called ACE-MAESTRO (Measurements of Aerosol Extinction in the Stratosphere and Troposphere Retrieved by Occultation) which extends the ACE wavelength coverage to the 280-1030 nm spectral region. The ACE instruments make solar occultation measurements from which altitude profiles of atmospheric trace gas species, temperature and pressure are retrieved. The 650 km altitude, 74 degree circular orbit provides global measurement coverage with a focus on the Arctic and Antarctic regions. These results are being used for studies relating to ozone depletion, climate-chemistry coupling and air pollution. As well, the decade long time series has been used to investigate trends in atmospheric constituents. This presentation will give an overview of the mission status and will provide a survey of the scientific results obtained from ACE.

  3. Radon measurement laboratories. An educational experience based on school and university cooperation

    Science.gov (United States)

    De Cicco, F.; Balzano, E.; Limata, B. N.; Masullo, M. R.; Quarto, M.; Roca, V.; Sabbarese, C.; Pugliese, M.

    2017-11-01

    There is a growing interest in engaging students and the general public about the meaning and objectives of doing science. When it is possible students can learn by actively engaging in the practices of science, conducting investigations, sharing ideas with their peers, teachers and scientists, learning to work with measuring apparatuses, to acquire and process data and use models so as to interpret phenomena. This is a process that requires a gradual collective growth. Schools and universities can both benefit from this cooperation. This paper presents activities of a project focusing on the radon survey in high schools. The ENVIRAD (environmental radioactivity) educational project involved about 2500 students and some tens of teachers in measurements while using solid state nuclear track detectors. This experience began about 15 years ago and is still carried out by various national projects managed by the same research group. The measurements and data analysis have been done in school laboratories and in the university radioactivity laboratory. Several hundred students were also involved in the transduction and signal processing. In some cases, pupils have also been involved in citizen awareness and the dissemination of this experience has kicked off a follow-up project explicitly addressed to citizens. The project has led to the opportunity to learn science through a real physics experiment. The students’ enthusiasm allowed the collection of a relevant amount of data which benefitted both the regional survey on radon and the improvement of nuclear physics teaching at school. Through the project activities it was possible to recognize the interdisciplinary connections among different scientific disciplines connected to radioactivity.

  4. Measuring Gas-Phase Basicities of Amino Acids Using an Ion Trap Mass Spectrometer: A Physical Chemistry Laboratory Experiment

    Science.gov (United States)

    Sunderlin, Lee S.; Ryzhov, Victor; Keller, Lanea M. M.; Gaillard, Elizabeth R.

    2005-01-01

    An experiment is performed to measure the relative gas-phase basicities of a series of five amino acids to compare the results to literature values. The experiments use the kinetic method for deriving ion thermochemistry and allow students to perform accurate measurements of thermodynamics in a relatively short time.

  5. Precision calculation of processes used for luminosity measurement at the ZEUS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Haas, T. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Makarenko, V. [NCPHEP, Minsk (Belarus)

    2010-09-15

    The process pe{sup {+-}} {yields} pe{sup {+-}}{gamma} with the photon emitted along the electron beam axis is used for luminosity measurement at HERA. In this paper the process is calculated including one-loop QED radiative corrections. In the ZEUS experiment, both the electron and the photon can be detected. Therefore both photon and electron spectra with and without the {gamma}-e coincidence are analyzed. We also calculate the process pe{sup {+-}} {yields} pe{sup {+-}}l{sup -}l{sup +} which contributes to the background in the electron tagger. (orig.)

  6. Precision calculation of processes used for luminosity measurement at the ZEUS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Haas, T. [DESY, Hamburg (Germany); Makarenko, V. [NCPHEP, Minsk (Belarus)

    2011-03-15

    The process pe {sup {+-}}{yields}pe{sup {+-}}{gamma} with the photon emitted along the electron beam axis is used for luminosity measurement at HERA. In this paper the process is calculated including one-loop QED radiative corrections. In the ZEUS experiment, both the electron and the photon can be detected. Therefore both photon and electron spectra with and without the {gamma}-e coincidence are analyzed. We also calculate the process pe{sup {+-}}{yields}pe {sup {+-}}l{sup -}l{sup +} which contributes to the background in the electron tagger. (orig.)

  7. Reynolds and Maxwell stress measurements in the reversed field pinch experiment Extrap-T2R

    Science.gov (United States)

    Vianello, N.; Antoni, V.; Spada, E.; Spolaore, M.; Serianni, G.; Cavazzana, R.; Bergsåker, H.; Cecconello, M.; Drake, J. R.

    2005-08-01

    The complete Reynolds stress (RS) has been measured in the edge region of the Extrap-T2R reversed field pinch experiment. The RS exhibits a strong gradient in the region where a high E × B shear takes place. Experimental results show this gradient to be almost entirely due to the electrostatic contribution. This has been interpreted as experimental evidence of flow generation via turbulence mechanism. The scales involved in flow generation are deduced from the frequency decomposition of RS tensor. They are found related to magnetohydrodynamic activity but are different with respect to the scales responsible for turbulent transport.

  8. A combination of preliminary results on gauge boson couplings measured by the LEP Experiments

    CERN Document Server

    CERN. Geneva

    2004-01-01

    This note presents a combination of published and preliminary measurements of triple gauge boson couplings (TGCs) and quartic gauge boson couplings (QGCs) from the four LEP experiments. We give an updated combination of the charged TGCs, g1z, kg and lg in single and multi-parameter fits. Updated results from the QGCs from the ZZgg vertex, ac/Lambda^2 and a0/Lambda^2, are given as well. The combinations of neutral TGCs hiv anf fiv are also presented, including an updated fiv combination.

  9. Danish Experiences with Deposit Probe Measurements in Grate and Pulverized Fuel Biomass Power Boilers

    DEFF Research Database (Denmark)

    Hansen, Stine Broholm; Jensen, Peter Arendt; Jappe Frandsen, Flemming

    2012-01-01

    Several measuring campaigns with focus on deposition behavior have been conducted at full-scale power plants firing biomass in Denmark. These campaigns have been reviewed in this work. The focus is the obtained experiences on deposit formation, shedding and chemistry. When comparing results from...... grate- and suspension-firing, it is found that the rates of deposit formation are comparable, while the chemical composition of the fly ashes are quite different, even for the same type of fuel. The flue gas temperature is considered to be an important parameter in the deposit behavior. Increasing...

  10. Zwitterionization of glycine in water environment: Stabilization mechanism and NMR spectral signatures.

    Science.gov (United States)

    Valverde, Danillo; da Costa Ludwig, Zélia Maria; da Costa, Célia Regina; Ludwig, Valdemir; Georg, Herbert C

    2018-01-14

    At physiological conditions, myriads of biomolecules (e.g., amino acids, peptides, and proteins) exist predominantly in the zwitterionic structural form and their biological functions will result in these conditions. However these geometrical structures are inaccessible energetically in the gas phase, and at this point, stabilization of amino-acids in physiological conditions is still under debate. In this paper, the electronic properties of a glycine molecule in the liquid environment were studied by performing a relaxation of the glycine geometry in liquid water using the free energy gradient method combined with a sequential quantum mechanics/molecular mechanics approach. A series of Monte Carlo Metropolis simulations of the glycine molecule embedded in liquid water, followed by only a quantum mechanical calculation in each of them were carried out. Both the local and global liquid environments were emphasized to obtain nuclear magnetic resonance (NMR) parameters for the glycine molecule in liquid water. The results of the equilibrium structure in solution and the systematic study of the hydrogen bonds were used to discard the direct proton transfer from the carboxyl group to the ammonium group of the glycine molecule in water solution. The calculations of the Density Functional Theory (DFT) were performed to study the polarization of the solvent in the parameters of nuclear magnetic resonance of the glycine molecule in liquid water. DFT calculations predicted isotropic chemical changes on the H, C, N, and O atoms of glycine in liquid water solution which agree with the available experimental data.

  11. D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period.

    Directory of Open Access Journals (Sweden)

    Claire N J Meunier

    Full Text Available N-methyl-D-aspartate receptors (NMDARs play a central role in synaptic plasticity. Their activation requires the binding of both glutamate and d-serine or glycine as co-agonist. The prevalence of either co-agonist on NMDA-receptor function differs between brain regions and remains undetermined in the visual cortex (VC at the critical period of postnatal development. Here, we therefore investigated the regulatory role that d-serine and/or glycine may exert on NMDARs function and on synaptic plasticity in the rat VC layer 5 pyramidal neurons of young rats. Using selective enzymatic depletion of d-serine or glycine, we demonstrate that d-serine and not glycine is the endogenous co-agonist of synaptic NMDARs required for the induction and expression of Long Term Potentiation (LTP at both excitatory and inhibitory synapses. Glycine on the other hand is not involved in synaptic efficacy per se but regulates excitatory and inhibitory neurotransmission by activating strychnine-sensitive glycine receptors, then producing a shunting inhibition that controls neuronal gain and results in a depression of synaptic inputs at the somatic level after dendritic integration. In conclusion, we describe for the first time that in the VC both D-serine and glycine differentially regulate somatic depolarization through the activation of distinct synaptic and extrasynaptic receptors.

  12. Purification and characterization of the glycine receptor of pig spinal cord

    Energy Technology Data Exchange (ETDEWEB)

    Graham, D.; Pfeiffer, F.; Simler, R.; Betz, H.

    1985-02-12

    A large-scale purification procedure was developed to isolate the glycine receptor of pig spinal cord by affinity chromatography on aminostrychnine agarose. After an overall purification of about 10,000-fold, the glycine receptor preparations contained three major polypeptides of Mr 48,000, 58,000, and 93,000. Photoaffinity labeling with (/sup 3/H)strychnine showed that the (/sup 3/H)strychnine binding site is associated with the Mr 48,000 and, to a much lesser extent, the Mr 58,000 polypeptides. (/sup 3/H)Strychnine binding to the purified receptor exhibited a dissociation constant K /sub D/ of 13.8 nM and was inhibited by the agonists glycine, taurine, and beta-alanine. Gel filtration and sucrose gradient centrifugation gave a Stokes radius of 7.1 nm and an apparent sedimentation coefficient of 9.6 S. Peptide mapping of the (/sup 3/H)strychnine-labeled Mr 48,000 polypeptides of purified pig and rat glycine receptor preparations showed that the strychnine binding region of this receptor subunit is highly conserved between these species. Also, three out of six monoclonal antibodies against the glycine receptor of rat spinal cord significantly cross-reacted with their corresponding polypeptides of the pig glycine receptor. These results show that the glycine receptor of pig spinal cord is very similar to the well-characterized rat receptor protein and can be purified in quantities sufficient for protein chemical analysis.

  13. A reliable method for spectrophotometric determination of glycine betaine in cell suspension and other systems.

    Science.gov (United States)

    Valadez-Bustos, Ma Guadalupe; Aguado-Santacruz, Gerardo Armando; Tiessen-Favier, Axel; Robledo-Paz, Alejandrina; Muñoz-Orozco, Abel; Rascón-Cruz, Quintin; Santacruz-Varela, Amalio

    2016-04-01

    Glycine betaine is a quaternary ammonium compound that accumulates in a large variety of species in response to different types of stress. Glycine betaine counteracts adverse effects caused by abiotic factors, preventing the denaturation and inactivation of proteins. Thus, its determination is important, particularly for scientists focused on relating structural, biochemical, physiological, and/or molecular responses to plant water status. In the current work, we optimized the periodide technique for the determination of glycine betaine levels. This modification permitted large numbers of samples taken from a chlorophyllic cell line of the grass Bouteloua gracilis to be analyzed. Growth kinetics were assessed using the chlorophyllic suspension to determine glycine betaine levels in control (no stress) cells and cells osmotically stressed with 14 or 21% polyethylene glycol 8000. After glycine extraction, different wavelengths and reading times were evaluated in a spectrophotometer to determine the optimal quantification conditions for this osmolyte. Optimal results were obtained when readings were taken at a wavelength of 290 nm at 48 h after dissolving glycine betaine crystals in dichloroethane. We expect this modification to provide a simple, rapid, reliable, and cheap method for glycine betaine determination in plant samples and cell suspension cultures. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Zwitterionization of glycine in water environment: Stabilization mechanism and NMR spectral signatures

    Science.gov (United States)

    Valverde, Danillo; da Costa Ludwig, Zélia Maria; da Costa, Célia Regina; Ludwig, Valdemir; Georg, Herbert C.

    2018-01-01

    At physiological conditions, myriads of biomolecules (e.g., amino acids, peptides, and proteins) exist predominantly in the zwitterionic structural form and their biological functions will result in these conditions. However these geometrical structures are inaccessible energetically in the gas phase, and at this point, stabilization of amino-acids in physiological conditions is still under debate. In this paper, the electronic properties of a glycine molecule in the liquid environment were studied by performing a relaxation of the glycine geometry in liquid water using the free energy gradient method combined with a sequential quantum mechanics/molecular mechanics approach. A series of Monte Carlo Metropolis simulations of the glycine molecule embedded in liquid water, followed by only a quantum mechanical calculation in each of them were carried out. Both the local and global liquid environments were emphasized to obtain nuclear magnetic resonance (NMR) parameters for the glycine molecule in liquid water. The results of the equilibrium structure in solution and the systematic study of the hydrogen bonds were used to discard the direct proton transfer from the carboxyl group to the ammonium group of the glycine molecule in water solution. The calculations of the Density Functional Theory (DFT) were performed to study the polarization of the solvent in the parameters of nuclear magnetic resonance of the glycine molecule in liquid water. DFT calculations predicted isotropic chemical changes on the H, C, N, and O atoms of glycine in liquid water solution which agree with the available experimental data.

  15. Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres

    Directory of Open Access Journals (Sweden)

    Paulo Celso Leventi Guimarães

    2013-01-01

    Full Text Available Colostrum is a secretion that contains immunologically active components, including immunocompetent cells and glycine, which has anti-inflammatory, immunomodulatory, and cytoprotective effects. The aim of this study was to evaluate the adsorption of glycine onto polyethylene glycol (PEG microspheres and to verify the immunomodulatory effect of this nanomaterial on human colostrum phagocytes. The PEG microspheres were evaluated by fluorescence microscopy. The effects of PEG microspheres with adsorbed glycine on viability, superoxide release, phagocytosis, microbicidal activity, and intracellular calcium release of mononuclear (MN and polymorphonuclear (PMN colostrum phagocytes were determined. Fluorescence microscopy analyses revealed that glycine was able to be adsorbed to the PEG microspheres. The PMN phagocytes exposed to glycine-PEG microspheres showed the highest superoxide levels. The phagocytes (both MN and PMN displayed increased microbicidal activity and intracellular calcium release in the presence of PEG microspheres with adsorbed glycine. These data suggest that the adsorption of PEG microspheres with adsorbed glycine was able to stimulate the colostrum phagocytes. This material may represent a possible alternative therapy for future clinical applications on patients with gastrointestinal infections.

  16. Characterisation of the human NMDA receptor subunit NR3A glycine binding site

    DEFF Research Database (Denmark)

    Nilsson, A; Duan, J; Mo-Boquist, L-L

    2007-01-01

    In this study, we characterise the binding site of the human N-methyl-d-aspartate (NMDA) receptor subunit NR3A. Saturation radioligand binding of the NMDA receptor agonists [(3)H]-glycine and [(3)H]-glutamate showed that only glycine binds to human NR3A (hNR3A) with high affinity (K(d)=535nM (277...... NR1 glycine site agonist d-serine and partial agonist HA-966 (3-amino-1-hydroxypyrrolid-2-one), similarly to glycine displaced [(3)H]-glycine monophasically, suggesting a single common binding site. However, neither the partial agonist d-cycloserine nor the antagonist 7-chlorokynurenic acid displaced...... [(3)H]-glycine. Using homology modelling, a model of the NR3A binding pocket was generated which we suggest can be used to identify candidate agonists and antagonists. Our data show that glycine is a ligand, and most probably the endogenous ligand, for native NR3A at a binding site with unique...

  17. Measurements of nitrous acid in commercial aircraft exhaust at the Alternative Aviation Fuel Experiment.

    Science.gov (United States)

    Lee, Ben H; Santoni, Gregory W; Wood, Ezra C; Herndon, Scott C; Miake-Lye, Richard C; Zahniser, Mark S; Wofsy, Steven C; Munger, J William

    2011-09-15

    The Alternative Aviation Fuel Experiment (AAFEX), conducted in January of 2009 in Palmdale, California, quantified aerosol and gaseous emissions from a DC-8 aircraft equipped with CFM56-2C1 engines using both traditional and synthetic fuels. This study examines the emissions of nitrous acid (HONO) and nitrogen oxides (NO(x) = NO + NO(2)) measured 145 m behind the grounded aircraft. The fuel-based emission index (EI) for HONO increases approximately 6-fold from idle to takeoff conditions but plateaus between 65 and 100% of maximum rated engine thrust, while the EI for NO(x) increases continuously. At high engine power, NO(x) EI is greater when combusting traditional (JP-8) rather than Fischer-Tropsch fuels, while HONO exhibits the opposite trend. Additionally, hydrogen peroxide (H(2)O(2)) was identified in exhaust plumes emitted only during engine idle. Chemical reactions responsible for emissions and comparison to previous measurement studies are discussed.

  18. Crystal Collimation efficiency measured with the Medipix detector in SPS UA9 experiment.

    CERN Document Server

    Laface, E; Tlustos, L; Ippolito, V

    2010-01-01

    The UA9 experiment was performed in 6 MDs from May to November 2009 with the goal of studying the collimation properties of a crystal in the framework of a future exploitation in the LHC collimation system. An important parameter evaluated for the characterization of the crystal collimation is the efficiency of halo extraction when the crystal is in channeling mode. In this paper it is explained how this efficiency can be measured using a pixel detector, the Medipix, installed in the Roman Pot of UA9. The number of extracted particles counted by the Medipix is compared with the total number of circulating particles measured by the Beam Current Transformers (BCTs): from this comparison the efficiency of the system composed by the crystal, used in channeling mode, and a tungsten absorber is proved to be greater than 85%.

  19. MEASUREMENTS OF COSMIC-RAY HYDROGEN AND HELIUM ISOTOPES WITH THE PAMELA EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    Adriani, O.; Bongi, M. [University of Florence, Department of Physics, I-50019 Sesto Fiorentino, Florence (Italy); Barbarino, G. C. [University of Naples “Federico II,” Department of Physics, I-80126 Naples (Italy); Bazilevskaya, G. A. [Lebedev Physical Institute, RU-119991, Moscow (Russian Federation); Bellotti, R.; Bruno, A. [University of Bari, Department of Physics, I-70126 Bari (Italy); Boezio, M.; Bonvicini, V.; Formato, V. [INFN, Sezione di Trieste, I-34149 Trieste (Italy); Bogomolov, E. A. [Ioffe Physical Technical Institute, RU-194021 St. Petersburg (Russian Federation); Bottai, S. [INFN, Sezione di Florence, I-50019 Sesto Fiorentino, Florence (Italy); Cafagna, F. [INFN, Sezione di Bari, I-70126 Bari (Italy); Campana, D. [INFN, Sezione di Naples, I-80126 Naples (Italy); Carlson, P. [KTH, Department of Physics, and the Oskar Klein Centre for Cosmoparticle Physics, AlbaNova University Centre, SE-10691 Stockholm (Sweden); Casolino, M.; Santis, C. De [University of Rome “Tor Vergata,” Department of Physics, I-00133 Rome (Italy); Castellini, G. [IFAC, I-50019 Sesto Fiorentino, Florence (Italy); Donato, C. De; Simone, N. De; Felice, V. Di [INFN, Sezione di Rome “Tor Vergata,” I-00133 Rome (Italy); and others

    2016-02-10

    The cosmic-ray hydrogen and helium ({sup 1}H, {sup 2}H, {sup 3}He, {sup 4}He) isotopic composition has been measured with the satellite-borne experiment PAMELA, which was launched into low-Earth orbit on board the Resurs-DK1 satellite on 2006 June 15. The rare isotopes {sup 2}H and {sup 3}He in cosmic rays are believed to originate mainly from the interaction of high-energy protons and helium with the galactic interstellar medium. The isotopic composition was measured between 100 and 1100 MeV/n for hydrogen and between 100 and 1400 MeV/n for helium isotopes using two different detector systems over the 23rd solar minimum from 2006 July to 2007 December.

  20. Exogenous Glycine Nitrogen Enhances Accumulation of Glycosylated Flavonoids and Antioxidant Activity in Lettuce (Lactuca sativa L.

    Directory of Open Access Journals (Sweden)

    Xiao Yang

    2017-12-01

    Full Text Available Glycine, the simplest amino acid in nature and one of the most abundant free amino acids in soil, is regarded as a model nutrient in organic nitrogen studies. To date, many studies have focused on the uptake, metabolism and distribution of organic nitrogen in plants, but few have investigated the nutritional performance of plants supplied with organic nitrogen. Lettuce (Lactuca sativa L., one of the most widely consumed leafy vegetables worldwide, is a significant source of antioxidants and bioactive compounds such as polyphenols, ascorbic acid and tocopherols. In this study, two lettuce cultivars, Shenxuan 1 and Lollo Rossa, were hydroponically cultured in media containing 4.5, 9, or 18 mM glycine or 9 mM nitrate (control for 4 weeks, and the levels of health-promoting compounds and antioxidant activity of the lettuce leaf extracts were evaluated. Glycine significantly reduced fresh weight compared to control lettuce, while 9 mM glycine significantly increased fresh weight compared to 4.5 or 18 mM glycine. Compared to controls, glycine (18 mM for Shenxuan 1; 9 mM for Lollo Rossa significantly increased the levels of most antioxidants (including total polyphenols, α-tocopherol and antioxidant activity, suggesting appropriate glycine supply promotes antioxidant accumulation and activity. Glycine induced most glycosylated quercetin derivatives and luteolin derivatives detected and decreased some phenolic acids compared to nitrate treatment. This study indicates exogenous glycine supplementation could be used strategically to promote the accumulation of health-promoting compounds and antioxidant activity of hydroponically grown lettuce, which could potentially improve human nutrition.

  1. Radiation Measurement Systems and Experiences in Japan after the Fukushima Accident

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    system to prove that rolls of grass harvested for animal feed meet the regulatory requirements. This document briefly describes the purpose of each measurement project, describes the instruments and assay method that used, and discusses some of the operational experiences from each of these projects. (authors)

  2. Conformational variability of the glycine receptor M2 domain in response to activation by different agonists

    DEFF Research Database (Denmark)

    Pless, Stephan Alexander; Dibas, Mohammed I; Lester, Henry A

    2007-01-01

    change. Although taurine and beta-alanine were weak partial agonists at the alpha1R19'C glycine receptor, they induced large fluorescence changes. Propofol, which drastically enhanced these currents, did not induce a glycine-like blue shift in the spectral emission peak. The inhibitors strychnine...... and picrotoxin elicited fluorescence and current changes as expected for a competitive antagonist and an open channel blocker, respectively. Glycine and taurine (or beta-alanine) also produced an increase and a decrease, respectively, in the fluorescence of a label attached to the nearby L22'C residue. Thus...

  3. Design of a surface deformation measuring instrument for the Surface Tension Driven Convection Experiment (STDCE-2)

    Science.gov (United States)

    Stahl, H. Philip

    1993-01-01

    This final technical report covers the work accomplished (under NAG3-1300) from 1 October 1991 to 1 October 1993. The grant is a direct result of Dr. H. Philip Stahl's (of Rose-Hulman Institute of Technology) participation in the NASA/ASEE Summer Faculty Fellowship Program at NASA Lewis Research Center sponsored by Case Western Reserve University and the Ohio Aerospace Institute. The Surface Tension Driven Convection Experiment (STDCE) is a fundamental fluid physics experiment designed to provide quantitative data on the thermocapillary flow of fluid under the influence of an increased localized surface temperature. STDCE flew on the Space Shuttle Columbia in the First United States Microgravity Laboratory (USML-1) in June 1992. The second flight of this experiment (STDCE-2) is scheduled for 1995. The specific science objectives of STDCE-2 are to determine the extent and nature of thermocapillary flows, the effect of heating mode and level, the effect of the liquid free-surface shape, and the onset conditions for and nature of oscillatory flows. In order to satisfy one of these objectives, an instrument for measuring the shape of an air/oil free surface must be developed.

  4. Analysis of balance beam deformation in the inertial mass measurement experiment

    Science.gov (United States)

    Fu, Zhuang; Zhang, Zhonghua; Li, Zhengkun; Li, Shisong

    2017-09-01

    This paper provides an analysis of mechanical balance beam deformation in the inertial mass measurement experiment since 2012. The relation between the applied test masses and three types of mechanical elastic deformation of the balance beam, i.e. the changes of rotational inertia, beam length and mass center, are discussed. It is found that changes in the rotational inertia and beam length are high order small quantities of the test mass, and a mechanically optimized balance beam which has good mechanical strength and a light structure is adopted to decrease the influence of the two types of deformation. The mass center change, being proportional to the test mass, has the most impact and can be compensated by a novel mass center compensation approach. Simulations and experiments confirm the effectiveness of the new balance beam and the mass center compensation method. It is emphasized that the analysis of the beam deformation in this paper can also be applied in other experiments where mechanical deformation of the balance beam needs to be considered.

  5. Field experiment provides ground truth for surface nuclear magnetic resonance measurement

    Science.gov (United States)

    Knight, R.; Grunewald, E.; Irons, T.; Dlubac, K.; Song, Y.; Bachman, H.N.; Grau, B.; Walsh, D.; Abraham, J.D.; Cannia, J.

    2012-01-01

    The need for sustainable management of fresh water resources is one of the great challenges of the 21st century. Since most of the planet's liquid fresh water exists as groundwater, it is essential to develop non-invasive geophysical techniques to characterize groundwater aquifers. A field experiment was conducted in the High Plains Aquifer, central United States, to explore the mechanisms governing the non-invasive Surface NMR (SNMR) technology. We acquired both SNMR data and logging NMR data at a field site, along with lithology information from drill cuttings. This allowed us to directly compare the NMR relaxation parameter measured during logging,T2, to the relaxation parameter T2* measured using the SNMR method. The latter can be affected by inhomogeneity in the magnetic field, thus obscuring the link between the NMR relaxation parameter and the hydraulic conductivity of the geologic material. When the logging T2data were transformed to pseudo-T2* data, by accounting for inhomogeneity in the magnetic field and instrument dead time, we found good agreement with T2* obtained from the SNMR measurement. These results, combined with the additional information about lithology at the site, allowed us to delineate the physical mechanisms governing the SNMR measurement. Such understanding is a critical step in developing SNMR as a reliable geophysical method for the assessment of groundwater resources.

  6. Monitoring ice thickness and elastic properties from the measurement of leaky guided waves: A laboratory experiment.

    Science.gov (United States)

    Moreau, Ludovic; Lachaud, Cédric; Théry, Romain; Predoi, Mihai V; Marsan, David; Larose, Eric; Weiss, Jérôme; Montagnat, Maurine

    2017-11-01

    The decline of Arctic sea ice extent is one of the most spectacular signatures of global warming, and studies converge to show that this decline has been accelerating over the last four decades, with a rate that is not reproduced by climate models. To improve these models, relying on comprehensive and accurate field data is essential. While sea ice extent and concentration are accurately monitored from microwave imagery, an accurate measure of its thickness is still lacking. Moreover, measuring observables related to the mechanical behavior of the ice (such as Young's modulus, Poisson's ratio, etc.) could provide better insights in the understanding of sea ice decline, by completing current knowledge so far acquired mostly from radar and sonar data. This paper aims at demonstrating on the laboratory scale that these can all be estimated simultaneously by measuring seismic waves guided in the ice layer. The experiment consisted of leaving a water tank in a cold room in order to grow an ice layer at its surface. While its thickness was increasing, ultrasonic guided waves were generated with a piezoelectric source, and measurements were subsequently inverted to infer the thickness and mechanical properties of the ice with very good accuracy.

  7. Optimal design of measurement settings for quantum-state-tomography experiments

    Science.gov (United States)

    Li, Jun; Huang, Shilin; Luo, Zhihuang; Li, Keren; Lu, Dawei; Zeng, Bei

    2017-09-01

    Quantum state tomography is an indispensable but costly part of many quantum experiments. Typically, it requires measurements to be carried out in a number of different settings on a fixed experimental setup. The collected data are often informationally overcomplete, with the amount of information redundancy depending on the particular set of measurement settings chosen. This raises a question about how one should optimally take data so that the number of measurement settings necessary can be reduced. Here, we cast this problem in terms of integer programming. For a given experimental setup, standard integer-programming algorithms allow us to find the minimum set of readout operations that can realize a target tomographic task. We apply the method to certain basic and practical state-tomographic problems in nuclear-magnetic-resonance experimental systems. The results show that considerably fewer readout operations can be found using our technique than by using the previous greedy search strategy. Therefore, our method could be helpful for simplifying measurement schemes to minimize the experimental effort.

  8. Simultaneous Measurement of Thermal Conductivity and Specific Heat in a Single TDTR Experiment

    Science.gov (United States)

    Sun, Fangyuan; Wang, Xinwei; Yang, Ming; Chen, Zhe; Zhang, Hang; Tang, Dawei

    2018-01-01

    Time-domain thermoreflectance (TDTR) technique is a powerful thermal property measurement method, especially for nano-structures and material interfaces. Thermal properties can be obtained by fitting TDTR experimental data with a proper thermal transport model. In a single TDTR experiment, thermal properties with different sensitivity trends can be extracted simultaneously. However, thermal conductivity and volumetric heat capacity usually have similar trends in sensitivity for most materials; it is difficult to measure them simultaneously. In this work, we present a two-step data fitting method to measure the thermal conductivity and volumetric heat capacity simultaneously from a set of TDTR experimental data at single modulation frequency. This method takes full advantage of the information carried by both amplitude and phase signals; it is a more convenient and effective solution compared with the frequency-domain thermoreflectance method. The relative error is lower than 5 % for most cases. A silicon wafer sample was measured by TDTR method to verify the two-step fitting method.

  9. Measuring Carbon and Oxygen Isotope Uptake into Inorganic Calcite using Crystal Growth Experiments

    Science.gov (United States)

    Baker, E. B.; Watkins, J. M.

    2014-12-01

    Carbon and oxygen isotopes measured on natural calcite crystals provide a record of paleo-environment conditions. Despite the importance of measuring stable isotopes in calcite for paleo-environment reconstructions, there is neither a general theory nor an experimental data set that fully separates the effects of pH, temperature, and precipitation rate on isotope discrimination during calcite growth. Many stable isotope studies of calcite have focused on either carbon or oxygen isotope compositions individually, but few have measured both carbon and oxygen isotope uptake in the same set of crystals. We are precipitating inorganic calcite across a range in temperature, pH, and precipitation rate to guide the development of a general theory for combined carbon and oxygen isotope uptake into calcite crystals grown on laboratory timescales. In our experiments, dissolved inorganic carbon (DIC) is added to an aqueous solution (15 mM CaCl2 + 5 mM NH4Cl) by CO2 bubbling. Once a critical supersaturation is reached, calcite crystals nucleate spontaneously and grow on the beaker walls. A key aspect of this experimental approach is that the δ13C of DIC is relatively constant throughout the crystal growth period, because there is a continuous supply of DIC from the CO2-bearing bubbles. Carbonic anhydrase, an enzyme promoting rapid equilibration of isotopes between DIC and water, was added to ensure that the solution remained isotopically equilibrated during calcite growth. We have conducted experiments at T = 25°C and pH = 8.3 - 9.0. We observe that the fractionation of oxygen isotopes between calcite and water decreases with increasing pH, consistent with available data from experiments in which the enzyme carbonic anhydrase was used. Our results for carbon isotopes extend the available data set, which previously ranged from pH 6.62 to 7.75, to higher pH. At pH 8.3, we observe that calcite is isotopically heavier than DIC with respect to carbon isotopes by about 0.25‰. At

  10. Reconstruction and measurement of cosmogenic signals in the neutrino experiment Borexino

    Energy Technology Data Exchange (ETDEWEB)

    Meindl, Johannes Quirin

    2013-06-14

    Underground laboratories around the globe provide low-count rate experiments with the necessary shielding against the large flux of cosmic muons present at the Earth's surface. Depending on the depth of the underground site, the muon flux is reduced by up to eight orders of magnitude. Hower, the residual muons, and the neutrons and radioisotopes they produce in nuclear spallation processes, still pose a significant background for many of these experiments. This thesis focusses on cosmogenic background signals in the neutrino experiment Borexino, which is located at the Laboratori Nazionali del Gran Sasso underground site at a depth of 3800 meters of water equivalent. The work encompasses the identification, spatial reconstruction, and measurement of rates and production yields of these cosmogenic events. For the efficient tagging of long-lived cosmogenic radioisotopes of lifetimes in the order of seconds and longer, the spatial reconstruction of the parent muon is essential. Based on the characteristic light emission profile of muons crossing the inner detector of Borexino, a new muon track reconstruction algorithm was developed. Furthermore, to increase the performance of the existing muon track reconstruction of Borexino's outer detector, a routine was programmed to automatically calibrate the photomultiplier tubes in timing and charge response. Muons entering the experiment can cause fast secondary signals from decays and captures of stopped muons, and the captures of muon-induced neutrons. To identify these events in the high noise environment after the muon, dedicated search algorithms were developed. Based on the detected signals, these fast muon-correlated events are studied. The fraction and lifetime of stopped muons are found to be in agreement with expectations. The production yield of cosmogenic neutrons is measured to (3.10{+-}0.07{sub stat}{+-}0.08{sub syst}) . 10{sup -4} n/({mu} . (g/cm{sup 2})). The corresponding capture time in the

  11. Experiment for the first direct measurement of the hyperfine splitting of positronium

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, A; Ishida, A; Asai, S [Department of Physics, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 133-0033 (Japan); Suehara, T; Namba, T; Kobayashi, T [International Center for Elementary Particle Physics (ICEPP), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 (Japan); Saito, H [Department of General Systems Studies, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902 (Japan); Yoshida, M [Accelerator Laboratory, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki, 305-0801 (Japan); Idehara, T; Ogawa, I; Urushizaki, Y [Research Center for Development of Far-Infrared Region, University of Fukui (FIR-FU), 3-9-1 Bunkyo, Fukui, Fukui, 910-8507 (Japan); Sabchevski, S, E-mail: miyazaki@icepp.s.u-tokyo.ac.j [Bulgarian Academy of Science, 1, 15 Noemvri Str., 1040 Sofia (Bulgaria)

    2010-04-01

    Positronium is an ideal system for the research of the bound state QED. The hyperfine splitting of positronium (Ps-HFS: about 203 GHz) is a good tool to test QED and also sensitive to new physics beyond the Standard Model via a quantum oscillation between an ortho-Ps and a virtual photon. Previous experimental results show 3.9 {sigma} (15 ppm) discrepancy from the QED calculation. All previous experiments used an indirect method with static magnetic field to cause Zeeman splitting (a few GHz) between triplet states of ortho-Ps, from which the HFS value was derived. One possible systematic error source of the indirect method is non-uniformity of the static magnetic field. We are developing a new direct Ps-HFS measurement system without static magnetic field. In this measurement we use a gyrotron, a novel sub-THz light source, with a high-finesse Fabry-Perot cavity to obtain enough radiation power at 203 GHz. The present status of the optimization studies and current design of the experiment are described.

  12. GUINEVERE experiment: Kinetic analysis of some reactivity measurement methods by deterministic and Monte Carlo codes

    Energy Technology Data Exchange (ETDEWEB)

    Bianchini, G.; Burgio, N.; Carta, M. [ENEA C.R. CASACCIA, via Anguillarese, 301, 00123 S. Maria di Galeria Roma (Italy); Peluso, V. [ENEA C.R. BOLOGNA, Via Martiri di Monte Sole, 4, 40129 Bologna (Italy); Fabrizio, V.; Ricci, L. [Univ. of Rome La Sapienza, C/o ENEA C.R. CASACCIA, via Anguillarese, 301, 00123 S. Maria di Galeria Roma (Italy)

    2012-07-01

    The GUINEVERE experiment (Generation of Uninterrupted Intense Neutrons at the lead Venus Reactor) is an experimental program in support of the ADS technology presently carried out at SCK-CEN in Mol (Belgium). In the experiment a modified lay-out of the original thermal VENUS critical facility is coupled to an accelerator, built by the French body CNRS in Grenoble, working in both continuous and pulsed mode and delivering 14 MeV neutrons by bombardment of deuterons on a tritium-target. The modified lay-out of the facility consists of a fast subcritical core made of 30% U-235 enriched metallic Uranium in a lead matrix. Several off-line and on-line reactivity measurement techniques will be investigated during the experimental campaign. This report is focused on the simulation by deterministic (ERANOS French code) and Monte Carlo (MCNPX US code) calculations of three reactivity measurement techniques, Slope ({alpha}-fitting), Area-ratio and Source-jerk, applied to a GUINEVERE subcritical configuration (namely SC1). The inferred reactivity, in dollar units, by the Area-ratio method shows an overall agreement between the two deterministic and Monte Carlo computational approaches, whereas the MCNPX Source-jerk results are affected by large uncertainties and allow only partial conclusions about the comparison. Finally, no particular spatial dependence of the results is observed in the case of the GUINEVERE SC1 subcritical configuration. (authors)

  13. Atmospheric Radiation Measurement Madden-Julian Oscillation Investigation Experiment Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Long, Chuck [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States). Earth System Research Lab.

    2016-07-01

    Every 30–90 days during the Northern Hemisphere winter, the equatorial tropical atmosphere experiences pulses of extraordinarily strong deep convection and rainfall. This phenomenon is referred to as the Madden–Julian Oscillation, or MJO, named after the scientists who identified this cycle. The MJO significantly affects weather and rainfall patterns around the world (Zhang 2013). To improve predictions of the MJO—especially about how it forms and evolves throughout its lifecycle—an international group of scientists collected an unprecedented set of observations from the Indian Ocean and western Pacific region from October 2011 through March 2012 through several coordinated efforts. The coordinated field campaigns captured six distinct MJO cycles in the Indian Ocean. The rich set of observations capturing several MJO events from these efforts will be used for many years to study the physics of the MJO. Here we highlight early research results using data from the Atmospheric Radiation Measurement (ARM) Madden-Julian Oscillation Investigation Experiment (AMIE), sponsored by the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility.

  14. Application of Optical Measurement Method in Brazilian Disk Splitting Experiment Under Dynamic Loading

    Directory of Open Access Journals (Sweden)

    Zhiqiang YIN

    2014-05-01

    Full Text Available A real-time and in situ optical measuring system is developed, which can be used to observe the determination of the displaced field on Brazilian disk splitting under dynamic loading. The system consists of high speed (HS photography, split-Hopkinson pressure bar (SHPB, synchronization controlling system and the operation of differential image. In the present experiments, photographs of the specimen were taken using a FASTCAM SA1.1 high speed camera, the frame rate was 100,000 fps. The continuous images of rock sample dynamic Brazil fracturing process and stress wave loading on the specimen were observed by synchronization controlling system. The change law of surface displacement field was calculated from the method of differential image base on the joint probability distribution function of two images. This method was considered the image correlation, and effectively eliminated the influence of background noise, and could identify the surface displacement and the occurrence and expansion of the crack in the dynamic Brazilian disk splitting experiments straightforward and effectively. This method can provide a novel measurement of surface displacement field in Brazilian disk splitting tests under high strain rates.

  15. Profile stiffness measurements in the Helically Symmetric experiment and comparison to nonlinear gyrokinetic calculations

    Energy Technology Data Exchange (ETDEWEB)

    Weir, G. M.; Faber, B. J.; Likin, K. M.; Talmadge, J. N.; Anderson, D. T.; Anderson, F. S. B. [HSX Plasma Laboratory, University of Wisconsin–Madison, Madison, Wisconsin 53706 (United States)

    2015-05-15

    Stiffness measurements are presented in the quasi-helically symmetric experiment (HSX), in which the neoclassical transport is comparable to that in a tokamak and turbulent transport dominates throughout the plasma. Electron cyclotron emission is used to measure the local electron temperature response to modulated electron cyclotron resonant heating. The amplitude and phase of the heat wave through the steep electron temperature gradient (ETG) region of the plasma are used to determine a transient electron thermal diffusivity that is close to the steady-state diffusivity. The low stiffness in the region between 0.2 ≤ r/a ≤ 0.4 agrees with the scaling of the steady-state heat flux with temperature gradient in this region. These experimental results are compared to gyrokinetic calculations in a flux-tube geometry using the gyrokinetic electromagnetic numerical experiment code with two kinetic species. Linear simulations show that the ETG mode may be experimentally relevant within r/a ≤ 0.2, while the Trapped Electron Mode (TEM) is the dominant long-wavelength microturbulence instability across most of the plasma. The TEM is primarily driven by the density gradient. Non-linear calculations of the saturated heat flux driven by the TEM and ETG bracket the experimental heat flux.

  16. A measurement of parity-violating asymmetries in the G0 experiment in forward mode

    Energy Technology Data Exchange (ETDEWEB)

    Covrig, Silviu Doru [California Inst. of Technology (CalTech), Pasadena, CA (United States)

    2004-01-01

    The G0 experiment in Hall C at Jefferson Lab measures the parity-violating asymmetry in elastic electron scattering off hydrogen and quasielastic electron scattering off deuterium in the Q2 range from 0.1 to 1 (GeV)2 in both forward and backward running modes by using a longitudinally polarized electron beam on unpolarized liquid targets. By measuring three independent asymmetries, one in forward running mode off liquid hydrogen and two in backward running mode, one off liquid hydrogen and one off liquid deuterium, the experiment aims to perform for the first time a complete separation and mapping of the strange vector form factors of the nucleon (G_Ms, G_Es) and the isovector axial form factor (G_Ae(T=1)) in three Q2 bins over the Q2 range from 0.1 to 1 (GeV/c)2. To complete the physics program in both forward and backward modes it will take about five years. To accomplish the forward running mode program some 100 C of data are needed. This thesis is based on 9 C of physics data taken during the first chekout of the G0 apparatus during October 2002 - January 2003.

  17. Probing supersymmetry based on precise jet measurements at the CMS experiment

    CERN Document Server

    Goebel, Kristin; Sander, Christian

    Abstract The search for new physics beyond the standard model of particle physics is one of the main goals of the CMS experiment at the CERN Large Hadron Collider. Many theories, for instance supersymmetry, involve the possible production of new coloured particles which feature jets as their experimental signature. Thus, it is important to have a good understanding of jet-related properties in order to allow such searches. In the rst part of this thesis, a measurement of the jet transverse-momentum resolution is presented. This is based on the analysis of proton-proton collision data recorded at a centre-of-mass energy of p s = 8 TeV by the CMS experiment. The measurement utilizes the transverse momentum balance of dijet events at particle level. The main focus is on the determination of the data-to-simulation ratio of the jet transverse-momentum resolution which can be used to correct the jet resolution in simulated events to match the one observed in data. This ratio has been determined with a signicantly i...

  18. Word knowledge in the crowd: Measuring vocabulary size and word prevalence in a massive online experiment.

    Science.gov (United States)

    Keuleers, Emmanuel; Stevens, Michaël; Mandera, Paweł; Brysbaert, Marc

    2015-01-01

    We use the results of a large online experiment on word knowledge in Dutch to investigate variables influencing vocabulary size in a large population and to examine the effect of word prevalence-the percentage of a population knowing a word-as a measure of word occurrence. Nearly 300,000 participants were presented with about 70 word stimuli (selected from a list of 53,000 words) in an adapted lexical decision task. We identify age, education, and multilingualism as the most important factors influencing vocabulary size. The results suggest that the accumulation of vocabulary throughout life and in multiple languages mirrors the logarithmic growth of number of types with number of tokens observed in text corpora (Herdan's law). Moreover, the vocabulary that multilinguals acquire in related languages seems to increase their first language (L1) vocabulary size and outweighs the loss caused by decreased exposure to L1. In addition, we show that corpus word frequency and prevalence are complementary measures of word occurrence covering a broad range of language experiences. Prevalence is shown to be the strongest independent predictor of word processing times in the Dutch Lexicon Project, making it an important variable for psycholinguistic research.

  19. A Measurement Of Parity-violating Asymmetries In The G(0) Experiment In Forward Mode

    CERN Document Server

    Covrig, S D

    2004-01-01

    The G0 (or G0) experiment in Hall C at Jefferson Lab measures the parity-violating asymmetry in elastic electron scattering off hydrogen and quasielastic electron scattering off deuterium in the Q2 range from 0.1 to 1 (GeV/c)2 in both forward and backward running modes by using a longitudinally polarized electron beam on unpolarized liquid targets. By measuring three independent asymmetries, one in forward running mode off liquid hydrogen and two in backward running mode; one off liquid hydrogen and one off liquid deuterium; the experiment aims to perform for the first time a complete separation and mapping of the strange vector form factors of the nucleon ( GsM,G sE ) and the isovector axial form factor ( GeA (T = 1)) in three Q2 bins over the Q2 range from 0.1 to 1 (GeV/c)2. To complete the physics program in both forward and backward modes it will take about five years. To accomplish the forward running mode program some 100 C of data are needed. This thesis is based on 9 C of physics data taken during t...

  20. Measurement of the radiative decay of polarized muons in the MEG experiment

    Energy Technology Data Exchange (ETDEWEB)

    Baldini, A.M.; Bemporad, C.; Cei, F.; D' Onofrio, A.; Dussoni, S.; Galli, L.; Grassi, M.; Nicolo, D.; Sergiampietri, F.; Signorelli, G.; Tenchini, F. [INFN, Sezione di Pisa (Italy); Dipartimento di Fisica, Pisa Univ. (Italy); Bao, Y.; Hildebrandt, M.; Kettle, P.R.; Mtchedlishvili, A.; Papa, A.; Ritt, S. [Paul Scherrer Institut PSI, Villigen (Switzerland); Baracchini, E. [ICEPP, The University of Tokyo, Tokyo (Japan); INFN, Laboratori Nazionali di Frascati, Frascati, Rome (Italy); Berg, F.; Hodge, Z.; Rutar, G. [Paul Scherrer Institut PSI, Villigen (Switzerland); Swiss Federal Institute of Technology ETH, Zurich (Switzerland); Biasotti, M.; De Gerone, M.; Gatti, F.; Pizzigoni, G. [INFN, Sezione di Genova (Italy); Dipartimento di Fisica, Genoa Univ. (Italy); Boca, G.; Cattaneo, P.W.; De Bari, A.; Rossella, M. [INFN, Sezione di Pavia (Italy); Dipartimento di Fisica, Pavia Univ. (Italy); Cavoto, G.; Graziosi, A.; Piredda, G.; Ripiccini, E.; Voena, C. [INFN, Sezione di Roma (Italy); Dipartimento di Fisica, ' ' Sapienza' ' Univ. Rome (Italy); Chiarello, G.; Chiri, C.; Grancagnolo, F.; Panareo, M.; Pepino, A.; Tassielli, G.F. [INFN, Sezione di Lecce (Italy); Dipartimento di Matematica e Fisica, Salento Univ. Lecce (Italy); Fujii, Y.; Iwamoto, T.; Kaneko, D.; Mori, Toshinori; Nakaura, S.; Nishimura, M.; Ogawa, S.; Ootani, W.; Sawada, R.; Uchiyama, Y.; Yoshida, K. [ICEPP, The University of Tokyo, Tokyo (Japan); Grigoriev, D.N. [Budker Institute of Nuclear Physics of Siberian Branch of Russian Academy of Sciences, Novosibirsk (Russian Federation); Novosibirsk State Technical University, Novosibirsk (Russian Federation); Novosibirsk State University, Novosibirsk (Russian Federation); Haruyama, T.; Mihara, S.; Nishiguchi, H.; Yamamoto, A. [KEK, High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan); Ieki, K. [Paul Scherrer Institut PSI, Villigen (Switzerland); ICEPP, The University of Tokyo, Tokyo (Japan); Ignatov, F.; Khazin, B.I.; Popov, A.; Yudin, Yu.V. [Budker Institute of Nuclear Physics of Siberian Branch of Russian Academy of Sciences, Novosibirsk (Russian Federation); Novosibirsk State University, Novosibirsk (Russian Federation); Kang, Tae Im; Lim, G.M.A.; Molzon, W.; You, Z. [University of California, Irvine, CA (United States); Khomutov, N.; Korenchenko, A.; Kravchuk, N. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Renga, F. [Paul Scherrer Institut PSI, Villigen (Switzerland); INFN, Sezione di Roma (Italy); Dipartimento di Fisica, ' ' Sapienza' ' Univ. Rome (Italy); Venturini, M. [INFN Sezione di Pisa (Italy); Dipartimento di Fisica, Pisa Univ. (Italy); Scuola Normale Superiore, Pisa (Italy); Collaboration: The MEG Collaboration

    2016-03-15

    We studied the radiative muon decay μ{sup +} → e{sup +}νanti νγ by using for the first time an almost fully polarized muon source. We identified a large sample (∝13,000) of these decays in a total sample of 1.8 x 10{sup 14} positive muon decays collected in the MEG experiment in the years 2009-2010 and measured the branching ratio B(μ{sup +} → eνanti νγ) = (6.03 ± 0.14(stat.) ± 0.53(sys.)) x 10{sup -8} for E{sub e} > 45 MeV and E{sub γ} > 40 MeV, consistent with the Standard Model prediction. The precise measurement of this decay mode provides a basic tool for the timing calibration, a normalization channel, and a strong quality check of the complete MEG experiment in the search for μ{sup +} → e{sup +}γ process. (orig.)

  1. The iso-response method: Measuring neuronal stimulus integration with closed-loop experiments

    Directory of Open Access Journals (Sweden)

    Tim eGollisch

    2012-12-01

    Full Text Available Throughout the nervous system, neurons integrate high-dimensional input streams and transform them into an output of their own. This integration of incoming signals involves filtering processes and complex nonlinear operations. The shapes of these filters and nonlinearities determine the computational features of single neurons and their functional roles within larger networks. A detailed characterization of signal integration is thus a central ingredient to understanding information processing in neural circuits. Conventional methods for measuring single-neuron response properties, such as reverse correlation, however, are often limited by the implicit assumption that stimulus integration occurs in a linear fashion. Here, we review a conceptual and experimental alternative that is based on exploring the space of those sensory stimuli that result in the same neural output. As demonstrated by recent results in the auditory and visual system, such iso-response stimuli can be used to identify the nonlinearities relevant for stimulus integration, disentangle subsequent neural processing steps, and determine their characteristics with unprecedented precision. Automated closed-loop experiments are crucial for this advance, allowing rapid search strategies for identifying iso-response stimuli during experiments. Prime targets for the method are feed-forward neural signaling chains in sensory systems, but the method has also been successfully applied to feedback systems. Depending on the specific question, iso-response may refer to a predefined firing rate, single-spike probability, first-spike latency, or other output measures. Examples from different studies show that substantial progress in understanding neural dynamics and coding can be achieved once rapid online data analysis and stimulus generation, adaptive sampling, and computational modelling are tightly integrated into experiments.

  2. Current CAPE-15: a measure of recent psychotic-like experiences and associated distress.

    Science.gov (United States)

    Capra, Carina; Kavanagh, David J; Hides, Leanne; Scott, James G

    2017-10-01

    Psychotic-like experiences (PLEs) are common in young people and are associated with both distress and adverse outcomes. The Community Assessment of Psychic Experiences-Positive Scale (CAPE-P) provides a 20-item measure of lifetime PLEs. A 15-item revision of this scale was recently published (CAPE-P15). Although the CAPE-P has been used to assess PLEs in the last 12 months, there is no version of the CAPE for assessing more recent PLEs (e.g. 3 months). This study aimed to determine the reliability and validity of the current CAPE-P15 and assess its relationship with current distress. A cross-sectional online survey of 489 university students (17-25 years) assessed lifetime and current substance use, current distress, and lifetime and 3-month PLEs on the CAPE-P15. Confirmatory factor analysis indicated that the current CAPE-P15 retained the same three-factor structure as the lifetime version consisting of persecutory ideation, bizarre experiences and perceptual abnormalities. The total score of the current version was lower than the lifetime version, but the two were strongly correlated (r = .64). The current version was highly predictive of generalized distress (r = .52) and indices that combined symptom frequency with associated distress did not confer greater predictive power than frequency alone. This study provided preliminary data that the current CAPE-P15 provides a valid and reliable measure of current PLEs. The current CAPE-P15 is likely to have substantial practical utility if it is later shown to be sensitive to change, especially in prevention and early intervention for mental disorders in young people. © 2015 Wiley Publishing Asia Pty Ltd.

  3. The iso-response method: measuring neuronal stimulus integration with closed-loop experiments

    Science.gov (United States)

    Gollisch, Tim; Herz, Andreas V. M.

    2012-01-01

    Throughout the nervous system, neurons integrate high-dimensional input streams and transform them into an output of their own. This integration of incoming signals involves filtering processes and complex non-linear operations. The shapes of these filters and non-linearities determine the computational features of single neurons and their functional roles within larger networks. A detailed characterization of signal integration is thus a central ingredient to understanding information processing in neural circuits. Conventional methods for measuring single-neuron response properties, such as reverse correlation, however, are often limited by the implicit assumption that stimulus integration occurs in a linear fashion. Here, we review a conceptual and experimental alternative that is based on exploring the space of those sensory stimuli that result in the same neural output. As demonstrated by recent results in the auditory and visual system, such iso-response stimuli can be used to identify the non-linearities relevant for stimulus integration, disentangle consecutive neural processing steps, and determine their characteristics with unprecedented precision. Automated closed-loop experiments are crucial for this advance, allowing rapid search strategies for identifying iso-response stimuli during experiments. Prime targets for the method are feed-forward neural signaling chains in sensory systems, but the method has also been successfully applied to feedback systems. Depending on the specific question, “iso-response” may refer to a predefined firing rate, single-spike probability, first-spike latency, or other output measures. Examples from different studies show that substantial progress in understanding neural dynamics and coding can be achieved once rapid online data analysis and stimulus generation, adaptive sampling, and computational modeling are tightly integrated into experiments. PMID:23267315

  4. Understanding the experience of food insecurity by elders suggests ways to improve its measurement.

    Science.gov (United States)

    Wolfe, Wendy S; Frongillo, Edward A; Valois, Pascale

    2003-09-01

    A full conceptualization of the elderly food insecurity experience has been lacking, leading to limitations in the definition and measurement of food insecurity in elders. Based on the qualitative analysis of two in-depth interviews 6 mo apart with each of 53 low income urban elders, using principles of grounded theory, the experience of elderly food insecurity was shown to have four components: quantitative, qualitative, psychological and social. The inability to obtain the right foods for health is a new element specific to elders. Common to each of these components were dimensions of severity, time and compromised food choice. Although money is a major cause of food insecurity, elders sometimes have enough money for food but are not able to access food because of transportation or functional limitations, or are not able to use food (i.e., not able to prepare or eat available food) because of functional impairments and health problems. These findings suggest that augmentation of the U.S. Household Food Security Survey Module (FSSM), a national measure of food insecurity based on research in younger persons, may result in more accurate assessments for elders. We developed 14 new items for possible augmentation and administered them by telephone to these same elders along with the FSSM. Elders were independently classified according to food insecurity status based on their experience from the in-depth interviews, and these definitive criteria were used to evaluate the new and existing items. The results suggest that "couldn't afford right foods for health" and two policy-relevant immediate causes, "couldn't get the food I needed" and possibly "unable to prepare," should be added, although further testing is needed.

  5. Measuring anhedonia: impaired ability to pursue, experience, and learn about reward

    Directory of Open Access Journals (Sweden)

    Kristine eRømer Thomsen

    2015-09-01

    Full Text Available Ribot’s long standing definition of anhedonia as the inability to experience pleasure has been challenged recently following progress in affective neuroscience. In particular, accumulating evidence suggests that reward consists of multiple subcomponents of wanting, liking and learning, as initially outlined by Berridge and Robinson, and these processes have been proposed to relate to appetitive, consummatory and satiety phases of a pleasure cycle. Building on this work, we recently proposed to reconceptualize anhedonia as impairments in the ability to pursue, experience and/or learn about pleasure, which is often, but not always accessible to conscious awareness. This framework is in line with Treadway and Zald’s proposal to differentiate between motivational and consummatory types of anhedonia, and stresses the need to combine traditional self-report measures with behavioral measures or procedures. In time, this approach may lead to improved clinical assessment and treatment. In line with our reconceptualization, increasing evidence suggests that reward processing deficits are not restricted to impaired hedonic impact in major psychiatric disorders. Successful translations of animal models have led to strong evidence of impairments in the ability to pursue and learn about reward in psychiatric disorders such as major depressive disorder, schizophrenia and addiction. It is of high importance that we continue to systematically target impairments in all phases of reward processing across disorders using behavioral testing in combination with neuroimaging techniques. This in turn has implications for diagnosis and treatment, and is essential for the purposes of identifying the underlying neurobiological mechanisms. Here I review recent progress in the development and application of behavioral procedures that measure subcomponents of anhedonia across relevant patient groups, and discuss methodological caveats as well as implications for

  6. Particle Morphology and Size Results from the Smoke Aerosol Measurement Experiment-2

    Science.gov (United States)

    Urban, David L.; Ruff, Gary A.; Greenberg, Paul S.; Fischer, David; Meyer, Marit; Mulholland, George; Yuan, Zeng-Guang; Bryg, Victoria; Cleary, Thomas; Yang, Jiann

    2012-01-01

    Results are presented from the Reflight of the Smoke Aerosol Measurement Experiment (SAME-2) which was conducted during Expedition 24 (July-September 2010). The reflight experiment built upon the results of the original flight during Expedition 15 by adding diagnostic measurements and expanding the test matrix. Five different materials representative of those found in spacecraft (Teflon, Kapton, cotton, silicone rubber and Pyrell) were heated to temperatures below the ignition point with conditions controlled to provide repeatable sample surface temperatures and air flow. The air flow past the sample during the heating period ranged from quiescent to 8 cm/s. The smoke was initially collected in an aging chamber to simulate the transport time from the smoke source to the detector. This effective transport time was varied by holding the smoke in the aging chamber for times ranging from 11 to 1800 s. Smoke particle samples were collected on Transmission Electron Microscope (TEM) grids for post-flight analysis. The TEM grids were analyzed to observe the particle morphology and size parameters. The diagnostics included a prototype two-moment smoke detector and three different measures of moments of the particle size distribution. These moment diagnostics were used to determine the particle number concentration (zeroth moment), the diameter concentration (first moment), and the mass concentration (third moment). These statistics were combined to determine the diameter of average mass and the count mean diameter and, by assuming a log-normal distribution, the geometric mean diameter and the geometric standard deviations can also be calculated. Overall the majority of the average smoke particle sizes were found to be in the 200 nm to 400 nm range with the quiescent cases producing some cases with substantially larger particles.

  7. Emotion self-regulation, psychophysiological coherence, and test anxiety: results from an experiment using electrophysiological measures.

    Science.gov (United States)

    Bradley, Raymond Trevor; McCraty, Rollin; Atkinson, Mike; Tomasino, Dana; Daugherty, Alane; Arguelles, Lourdes

    2010-12-01

    This study investigated the effects of a novel, classroom-based emotion self-regulation program (TestEdge) on measures of test anxiety, socioemotional function, test performance, and heart rate variability (HRV) in high school students. The program teaches students how to self-generate a specific psychophysiological state--psychophysiological coherence--which has been shown to improve nervous system function, emotional stability, and cognitive performance. Implemented as part of a larger study investigating the population of tenth grade students in two California high schools (N = 980), the research reported here was conducted as a controlled pre- and post-intervention laboratory experiment, using electrophysiological measures, on a random stratified sample of students from the intervention and control schools (N = 136). The Stroop color-word conflict test was used as the experiment's stimulus to simulate the stress of taking a high-stakes test, while continuous HRV recordings were gathered. The post-intervention electrophysiological results showed a pattern of improvement across all HRV measures, indicating that students who received the intervention program had learned how to better manage their emotions and to self-activate the psychophysiological coherence state under stressful conditions. Moreover, students with high test anxiety exhibited increased HRV and heart rhythm coherence even during a resting baseline condition (without conscious use of the program's techniques), suggesting that they had internalized the benefits of the intervention. Consistent with these results, students exhibited reduced test anxiety and reduced negative affect after the intervention. Finally, there is suggestive evidence from a matched-pairs analysis that reduced test anxiety and increased psychophysiological coherence appear to be directly associated with improved test performance--a finding consistent with evidence from the larger study.

  8. Precise measurement in elastic electron scattering: HAPPEX and E-158 experiments; Mesures precises de violation de parite en diffusion d'electrons: experiences HAPPEX et E-158

    Energy Technology Data Exchange (ETDEWEB)

    Vacheret, A

    2004-12-01

    Parity Violation asymmetry measurements in elastic electron scattering are in one hand an interesting way of retrieving new informations about the sea quarks of the nucleon and in the other hand a powerful test of the Standard Model electroweak sector at low energy. This thesis describes the HAPPEX experiment at JLab and the E-158 experiment at SLAC (USA) which measure de parity violation asymmetries in elastic scattering of polarized electron on nuclei like Hydrogen or Helium and on atomic electrons. With the measurements on hadronic targets one can extract the strange quarks contribution to the charge and current density of the nucleon. With the electron-electron scattering one can test the standard model at the loop level and far from the Z pole by extracting sin{sup 2} {theta}{sub W}. In this thesis we describe the formalism associated with the electroweak probe. We present in detail the experimental methods used to make such precise measurements of parity violation asymmetry. Then, we describe the experimental set-up of each experiment and in particular the electron detector and the feedback loop on the beam current for the HAPPEX experiment and the analysis of E-158 run III with a dedicated systematic study on the beam sub-pulse fluctuations. We present the preliminary results for each experiment with a comparison with the other existing results and the future experiments. (author)

  9. Atmospheric PCDD/F measurement in Taiwan and Southeast Asia during Dongsha Experiment

    Science.gov (United States)

    Thuan, Ngo Thi; Chi, Kai Hsien; Wang, Sheng-Hsiang; Chang, Moo Been; Lin, Neng-Huei; Sheu, Guey-Rong; Peng, Chi-Ming

    2013-10-01

    The international campaign of Dongsha Experiment was conducted in the northern Southeast Asian region during March-May 2010. To address the effects of long-range transport on the persistent organic pollutants and further understand the PCDD/F contamination in Vietnam, atmospheric PCDD/Fs were evaluated at a coastal station (Pingtung County, Sites A) in southern Taiwan, remote island station in South China Sea (Dongsha Island, Site B) and coastal station (Da Nang City, Site C) in central Vietnam during different sampling periods in this study. The measurements indicated that the atmospheric PCDD/F concentrations were 1.01-27.4 fg I-TEQ/m3 (n = 22), 1.52-10.8 fg I-TEQ/m3 (n = 17) and 23.4-146 fg I-TEQ/m3 (n = 16) at Sites A, B and C, respectively, during different periods in 2010. In March 2010, an Asian dust storm (ADS) that originated in Gobi deserts eventually reached populated areas of East Asia, including Taiwan and the island in northern South China Sea. During the ADS episode, measurements made in southern Taiwan and South China Sea on 16 and 21 March 2010 indicate that the atmospheric PCDD/F concentration increased 6.5 and 6.9 times at Sites A and B, respectively. Furthermore, the significantly higher PCDD/F concentrations and contents in suspended particles (134-546 pg I-TEQ/g-TSP) were measured at Site C in the central Vietnam. In addition, the distribution of PCDD/F congeners measured in Central Vietnam was quite different from those measured at other stations with high PCDD distribution (>80%) especially in OCDD (>70%). During the Vietnam conflict, United States (US) forces had sprayed a greater volume of defoliant with higher PCDD/F contents than originally estimated. We consider that the high fraction of PCDDs observed in Vietnam probably originated as anthropogenic emission from specific source in Vietnam.

  10. THE Q/U IMAGING EXPERIMENT: POLARIZATION MEASUREMENTS OF RADIO SOURCES AT 43 AND 95 GHz

    Energy Technology Data Exchange (ETDEWEB)

    Huffenberger, K. M. [Department of Physics, Florida State University, P.O. Box 3064350, Tallahassee, FL 32306-4350 (United States); Araujo, D.; Zwart, J. T. L. [Department of Physics and Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Bischoff, C.; Buder, I. [Kavli Institute for Cosmological Physics, Department of Physics, Enrico Fermi Institute, The University of Chicago, Chicago, IL 60637 (United States); Chinone, Y.; Hasegawa, M. [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Cleary, K. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, 1200 E. California Blvd M/C 249-17, Pasadena, CA 91125 (United States); Kusaka, A. [Physics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Monsalve, R. [School of Earth and Space Exploration, Arizona State University, 781 E. Terrace Road, Tempe, AZ 85287 (United States); Næss, S. K. [Department of Astrophysics, University of Oxford, Keble Road, Oxford, OX1 3RH (United Kingdom); Newburgh, L. B. [Dunlap Institute, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H4 (Canada); Reeves, R. [CePIA, Departamento de Astronomía, Universidad de Concepción (Chile); Ruud, T. M.; Eriksen, H. K. [Institute of Theoretical Astrophysics, University of Oslo, P.O. Box 1029 Blindern, NO-0315 Oslo (Norway); Wehus, I. K.; Gaier, T. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Dickinson, C. [Jodrell Bank Centre for Astrophysics, Alan Turing Building, School of Physics and Astronomy, The University of Manchester, Oxford Road, Manchester M13 9PL (United Kingdom); Gundersen, J. O., E-mail: huffenbe@physics.fsu.edu [Department of Physics, University of Miami, 1320 Campo Sano Drive, Coral Gables, FL 33146 (United States); Collaboration: QUIET Collaboration; and others

    2015-06-10

    We present polarization measurements of extragalactic radio sources observed during the cosmic microwave background polarization survey of the Q/U Imaging Experiment (QUIET), operating at 43 GHz (Q-band) and 95 GHz (W-band). We examine sources selected at 20 GHz from the public, >40 mJy catalog of the Australia Telescope (AT20G) survey. There are ∼480 such sources within QUIET’s four low-foreground survey patches, including the nearby radio galaxies Centaurus A and Pictor A. The median error on our polarized flux density measurements is 30–40 mJy per Stokes parameter. At signal-to-noise ratio > 3 significance, we detect linear polarization for seven sources in Q-band and six in W-band; only 1.3 ± 1.1 detections per frequency band are expected by chance. For sources without a detection of polarized emission, we find that half of the sources have polarization amplitudes below 90 mJy (Q-band) and 106 mJy (W-band), at 95% confidence. Finally, we compare our polarization measurements to intensity and polarization measurements of the same sources from the literature. For the four sources with WMAP and Planck intensity measurements >1 Jy, the polarization fractions are above 1% in both QUIET bands. At high significance, we compute polarization fractions as much as 10%–20% for some sources, but the effects of source variability may cut that level in half for contemporaneous comparisons. Our results indicate that simple models—ones that scale a fixed polarization fraction with frequency—are inadequate to model the behavior of these sources and their contributions to polarization maps.

  11. Filter measurements of chemical composition during the airborne Antarctic ozone experiment

    Science.gov (United States)

    Grandrud, B. W.; Sperry, P. D.; Sanford, L.

    1988-01-01

    During the Airborne Antarctic Ozone Experiment campaign, a filter sampler was flown to measure the bulk composition of aerosol and gas phases. The background sulfate aerosol was measured in regions inside and outside of the chemically perturbed region (CPR) of the polar vortex. The mass ratio of sulfate outside to inside was 2.8. This is indicative of a cleansing mechanism effecting the CPR or of a different air mass inside versus outside. The absolute value of the sulfate mixing ratio shows that the background aerosol has not been influenced by recent volcanic eruptions. The sulfate measured on the ferry flight returning to NASA Ames shows a decrease towards the equator with increasing concentrations in the northern hemisphere. Nitrate in the aerosol phase was observed on two flights. The largest amount of nitrate measured in the aerosol was 44 percent of the total amount of nitrate observed. Other samples on the same flights show no nitrate in the aerosol phase. The presence of nitrate in the aerosol is correlated with the coldest temperatures observed on a given flight. Total nitrate (aerosol plus acidic vapor nitrate) concentrations were observed to increase at flight altitude with increasing latitude north and south of the equator. Total nitrate was lower inside the CPR than outside. Chloride and flouride were not detected in the aerosol phase. From the concentrations of acidic chloride vapor, the ratio of acidic vapor Cl to acidic vapor F and a summing of the individual chloride containing species to yield a total chloride concentration, there is a suggestion that some of the air sampled was dechlorinated. Acidic vapor phase fluoride was observed to increase at flight altitude with increasing latitude both north and south of the equator. The acidic vapor phase fluoride was the only compound measured with the filter technique that exhibited larger concentrations inside the CPR than outside.

  12. A measurement of neutrino oscillations with muon neutrinos in the MINOS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Stephen James [College of William and Mary, Williamsburg, VA (United States)

    2011-05-01

    Experimental evidence has established that neutrino flavor states evolve over time. A neutrino of a particular flavor that travels some distance can be detected in a different neutrino flavor state. The Main Injector Neutrino Oscillation Search (MINOS) is a long-baseline experiment that is designed to study this phenomenon, called neutrino oscillations. MINOS is based at Fermilab near Chicago, IL, and consists of two detectors: the Near Detector located at Fermilab, and the Far Detector, which is located in an old iron mine in Soudan, MN. Both detectors are exposed to a beam of muon neutrinos from the NuMI beamline, and MINOS measures the fraction of muon neutrinos that disappear after traveling the 734 km between the two detectors. One can measure the atmospheric neutrino mass splitting and mixing angle by observing the energy-dependence of this muon neutrino disappearance. MINOS has made several prior measurements of these parameters. Here I describe recently-developed techniques used to enhance our sensitivity to the oscillation parameters, and I present the results obtained when they are applied to a dataset that is twice as large as has been previously analyzed. We measure the mass splitting Δm232 = (2.32-0.08+0.12) x 10-3 eV2/c4 and the mixing angle sin2(2θ32) > 0.90 at 90% C.L. These results comprise the world's best measurement of the atmospheric neutrino mass splitting. Alternative disappearance models are also tested. The neutrino decay hypothesis is disfavored at 7.2σ and the neutrino quantum decoherence hypothesis is disfavored at 9.0σ.

  13. Effects of β-sheet crystals and a glycine-rich matrix on the thermal conductivity of spider dragline silk.

    Science.gov (United States)

    Park, Jinju; Kim, Duckjong; Lee, Seung-Mo; Choi, Ji-Ung; You, Myungil; So, Hye-Mi; Han, Junkyu; Nah, Junghyo; Seol, Jae Hun

    2017-03-01

    We measured the thermal conductivity of Araneus ventricosus' spider dragline silk using a suspended microdevice. The thermal conductivity of the silk fiber was approximately 0.4Wm-1K-1 at room temperature and gradually increased with an increasing temperature in a manner similar to that of other disordered crystals or proteins. In order to elucidate the effect of β-sheet crystals in the silk, thermal denaturation was used to reduce the quantity of the β-sheet crystals. A calculation with an effective medium approximation supported this measurement result showing that the thermal conductivity of β-sheet crystals had an insignificant effect on the thermal conductivity of SDS. Additionally, the enhancement of bonding strength in a glycine-rich matrix by atomic layer deposition did not increase the thermal conductivity. Thus, this study suggests that the disordered part of the glycine-rich matrix prevented the peptide chains from being coaxially extended via the cross-linking covalent bonds. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Synthesis and crystal structures of novel copper(II) complexes with glycine and substituted phenanthrolines: reactivity towards DNA/BSA and in vitro cytotoxic and antimicrobial evaluation.

    Science.gov (United States)

    İnci, Duygu; Aydın, Rahmiye; Vatan, Özgür; Sevgi, Tuba; Yılmaz, Dilek; Zorlu, Yunus; Yerli, Yusuf; Çoşut, Bünyemin; Demirkan, Elif; Çinkılıç, Nilüfer

    2017-01-01

    New copper(II) complexes-dimeric-[Cu(nphen)(gly)(H 2 O)] + (1) and [Cu(dmphen)(gly)(NO 3 )(H 2 O)] (2) (nphen = 5-nitro-1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline, and gly = glycine)-have been synthesized and characterized by CHN analysis, single-crystal X-ray diffraction techniques, FTIR, EPR spectroscopy, and cyclic voltammetry. The CT-DNA-binding properties of these complexes have been investigated by thermal denaturation measurements and both absorption and emission spectroscopy. The DNA cleavage activity of these complexes has been studied on supercoiled pUC19 plasmid DNA by gel electrophoresis experiments in the absence and presence of H 2 O 2 . Furthermore, the interaction of these complexes with bovine serum albumin (BSA) has been investigated using absorption and emission spectroscopy. The thermodynamic parameters, free-energy change (ΔG), enthalpy change (ΔH), and entropy change (ΔS) for BSA + complexes 1 and 2 systems have been calculated by the van't Hoff equation at three different temperatures (293.2, 303.2, and 310.2 K). The distance between the BSA and these complexes has been determined using fluorescence resonance energy transfer (FRET). Conformational changes of BSA have been observed using the synchronous fluorescence technique. In addition, in vitro cytotoxicities of these complexes on tumor cell lines (Caco-2, A549, and MCF-7) and healthy cells (BEAS-2B) have been examined. The antimicrobial activity of the complexes has also been tested on certain bacteria cells. The effect of mono and dimeric in the above complexes is presented and discussed. New copper(II) complexes-dimeric-[Cu(nphen)(gly)(H 2 O)] + (1) and [Cu(dmphen)(gly) (NO 3 )(H 2 O)] (2) (nphen = 5-nitro-1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline and gly = glycine)-have been synthesized and characterized by CHN analysis, single-crystal X-ray diffraction techniques, FTIR and EPR spectroscopy. They have been tested for their in vitro

  15. Behavioral measures of cortical hyperexcitability assessed in people who experience visual snow.

    Science.gov (United States)

    McKendrick, Allison M; Chan, Yu Man; Tien, Melissa; Millist, Lynette; Clough, Meaghan; Mack, Heather; Fielding, Joanne; White, Owen B

    2017-03-28

    To determine whether visual perceptual measures in people who experience visual snow are consistent with an imbalance between inhibition and excitation in visual cortex. Sixteen patients with visual snow and 18 controls participated. Four visual tasks were included: center-surround contrast matching, luminance increment detection in noise, and global form and global motion coherence thresholds. Neuronal architecture capable of encoding the luminance and contrast stimuli is present within primary visual cortex, whereas the extraction of global motion and form signals requires extrastriate processing. All these tasks have been used previously to investigate the balance between inhibition and excitation within the visual system in both healthy and diseased states. The visual snow group demonstrated reduced center-surround contrast suppression (p = 0.03) and elevated luminance increment thresholds in noise (p = 0.02). Groups did not differ on the global form or global motion task. Our study demonstrates that visual perceptual measures involving the suprathreshold processing of contrast and luminance are abnormal in a group of individuals with visual snow. Our data are consistent with elevated excitability in primary visual cortex; however, further research is required to provide more direct evidence for this proposed mechanism. The ability to measure perceptual differences in visual snow reveals promise for the future development of clinical tests to assist in visual snow diagnosis and possibly a method for quantitatively assaying any benefits of treatments. © 2017 American Academy of Neurology.

  16. Struggling for recognition and inclusion-parents' and pupils' experiences of special support measures in school.

    Science.gov (United States)

    Isaksson, Joakim; Lindqvist, Rafael; Bergström, Erik

    2010-02-08

    During the last decade an increasing use of differentiated support measures for pupils with special educational needs, indicative of a discrepancy between educational policies and practices, has been witnessed in Sweden. Another trend has been the increased use of medical diagnoses in school. The aim of this study was to explore the main concern of support given to pupils with special educational needs and how pupils and parents experience and handle this. Interviews were conducted with eight pupils in Grades 7-9-and their parents-at two compulsory schools in a city in northern Sweden. A grounded theory approach was used for analyzing the interview data. A conceptual model was generated illuminating the main concern of special support measures for pupils and parents. The core category of the model, struggling for recognition and inclusion, was related to two categories, which further described how this process was experienced and handled by the participants. These categories were labeled negotiating expertise knowledge within a fragmented support structure and coping with stigma, ambivalence, and special support measures. The developed conceptual model provides a deeper understanding of an ongoing process of struggle for recognition and inclusion in school as described by the pupils and parents.

  17. Surface studies and implanted helium measurements following NOVA high-yield DT experiments

    Energy Technology Data Exchange (ETDEWEB)

    Stoyer, M.A.; Hudson, G.B.

    1997-02-18

    This paper presents the results of three March 6, 1996 direct-drive high-yield DT NOVA experiments and provides `proof-of-principal` results for the quantitative measurement of energetic He ions. Semiconductor quality Si wafers and an amorphous carbon wafer were exposed to NOVA high-yield implosions. Surface damage was sub-micron in general, although the surface ablation was slightly greater for the carbon wafer than for the Si wafers. Melting of a thin ({approx} 0.1{mu}) layer of Si was evident from microscopic investigation. Electron microscopy indicated melted blobs of many different metals (e.g. Al, Au, Ta, Fe alloys, Cu and even Cd) on the surfaces. The yield measured by determining the numbers of atoms of implanted {sup 4}He and {sup 3}He indicate the number of DT fusions to be 9.1({plus_minus}2.3) X 10{sup 12} and DD fusions to be 4.8({plus_minus}1.0) x 10{sup 10}, respectively. The helium DT fusion yield is slightly lower than that of the Cu activation measurement, which was 1.3({plus_minus}0.l) x 10{sup 13} DT fusions.

  18. First measurement of isoscalar giant resonances in a stored-beam experiment

    Directory of Open Access Journals (Sweden)

    J.C. Zamora

    2016-12-01

    Full Text Available A new technique developed for measuring nuclear reactions at low momentum transfer with stored beams in inverse kinematics was successfully used to study isoscalar giant resonances. The experiment was carried out at the experimental heavy-ion storage ring (ESR at the GSI facility using a stored 58Ni beam at 100 MeV/u and an internal helium gas-jet target. In these measurements, inelastically scattered α-recoils at very forward center-of-mass angles (θcm≤1.5° were detected with a dedicated setup, including ultra-high vacuum compatible detectors. Experimental results indicate a dominant contribution of the isoscalar giant monopole resonance at this very forward angular range. It was found that the monopole contribution exhausts 79−11+12% of the energy-weighted sum rule (EWSR, which agrees with measurements performed in normal kinematics. This opens up the opportunity to investigate the giant resonances in a large domain of unstable and exotic nuclei in the near future. It is a fundamental milestone towards new nuclear reaction studies with stored ion beams.

  19. Adaptive Measurement of Well-Being: Maximizing Efficiency and Optimizing User Experience during Individual Assessment.

    Science.gov (United States)

    Kraatz, Miriam; Sears, Lindsay E; Coberley, Carter R; Pope, James E

    2016-08-01

    Well-being is linked to important societal factors such as health care costs and productivity and has experienced a surge in development activity of both theories and measurement. This study builds on validation of the Well-Being 5 survey and for the first time applies Item Response Theory, a modern and flexible measurement paradigm, to form the basis of adaptive population well-being measurement. Adaptive testing allows survey questions to be administered selectively, thereby reducing the number of questions required of the participant. After the graded response model was fit to a sample of size N = 12,035, theta scores were estimated based on both the full-item bank and a simulation of Computerized Adaptive Testing (CAT). Comparisons of these 2 sets of score estimates with each other and of their correlations with external outcomes of job performance, absenteeism, and hospital admissions demonstrate that the CAT well-being scores maintain accuracy and validity. The simulation indicates that the average survey taker can expect a reduction in number of items administered during the CAT process of almost 50%. An increase in efficiency of this extent is of considerable value because of the time savings during the administration of the survey and the potential improvement of user experience, which in turn can help secure the success of a total population-based well-being improvement program. (Population Health Management 2016;19:284-290).

  20. Struggling for recognition and inclusion–parents’ and pupils’ experiences of special support measures in school

    Directory of Open Access Journals (Sweden)

    Joakim Isaksson

    2010-02-01

    Full Text Available During the last decade an increasing use of differentiated support measures for pupils with special educational needs, indicative of a discrepancy between educational policies and practices, has been witnessed in Sweden. Another trend has been the increased use of medical diagnoses in school. The aim of this study was to explore the main concern of support given to pupils with special educational needs and how pupils and parents experience and handle this. Interviews were conducted with eight pupils in Grades 7–9—and their parents—at two compulsory schools in a city in northern Sweden. A grounded theory approach was used for analyzing the interview data. A conceptual model was generated illuminating the main concern of special support measures for pupils and parents. The core category of the model, struggling for recognition and inclusion, was related to two categories, which further described how this process was experienced and handled by the participants. These categories were labeled negotiating expertise knowledge within a fragmented support structure and coping with stigma, ambivalence, and special support measures. The developed conceptual model provides a deeper understanding of an ongoing process of struggle for recognition and inclusion in school as described by the pupils and parents.

  1. A measurement of coherent neutral pion production in neutrino neutral current interactions in the NOMAD experiment

    Science.gov (United States)

    Kullenberg, C. T.; Mishra, S. R.; Seaton, M. B.; Kim, J. J.; Tian, X. C.; Scott, A. M.; Kirsanov, M.; Petti, R.; Alekhin, S.; Astier, P.; Autiero, D.; Baldisseri, A.; Baldo-Ceolin, M.; Banner, M.; Bassompierre, G.; Benslama, K.; Besson, N.; Bird, I.; Blumenfeld, B.; Bobisut, F.; Bouchez, J.; Boyd, S.; Bueno, A.; Bunyatov, S.; Camilleri, L.; Cardini, A.; Cattaneo, P. W.; Cavasinni, V.; Cervera-Villanueva, A.; Challis, R.; Chukanov, A.; Collazuol, G.; Conforto, G.; Conta, C.; Contalbrigo, M.; Cousins, R.; Degaudenzi, H.; De Santo, A.; Del Prete, T.; Di Lella, L.; do Couto e Silva, E.; Dumarchez, J.; Ellis, M.; Feldman, G. J.; Ferrari, R.; Ferrère, D.; Flaminio, V.; Fraternali, M.; Gaillard, J.-M.; Gangler, E.; Geiser, A.; Geppert, D.; Gibin, D.; Gninenko, S.; Godley, A.; Gomez-Cadenas, J.-J.; Gosset, J.; Gößling, C.; Gouanère, M.; Grant, A.; Graziani, G.; Guglielmi, A.; Hagner, C.; Hernando, J.; Hurst, P.; Hyett, N.; Iacopini, E.; Joseph, C.; Juget, F.; Kent, N.; Klimov, O.; Kokkonen, J.; Kovzelev, A.; Krasnoperov, A.; Kulagin, S.; Lacaprara, S.; Lachaud, C.; Lakić, B.; Lanza, A.; La Rotonda, L.; Laveder, M.; Letessier-Selvon, A.; Levy, J.-M.; Ling, J.; Linssen, L.; Ljubičić, A.; Long, J.; Lupi, A.; Lyubushkin, V.; Marchionni, A.; Martelli, F.; Méchain, X.; Mendiburu, J.-P.; Meyer, J.-P.; Mezzetto, M.; Moorhead, G. F.; Naumov, D.; Nédélec, P.; Nefedov, Yu.; Nguyen-Mau, C.; Orestano, D.; Pastore, F.; Peak, L. S.; Pennacchio, E.; Pessard, H.; Placci, A.; Polesello, G.; Pollmann, D.; Polyarush, A.; Poulsen, C.; Popov, B.; Rebuffi, L.; Rico, J.; Riemann, P.; Roda, C.; Rubbia, A.; Salvatore, F.; Samoylov, O.; Schahmaneche, K.; Schmidt, B.; Schmidt, T.; Sconza, A.; Sevior, M.; Sillou, D.; Soler, F. J. P.; Sozzi, G.; Steele, D.; Stiegler, U.; Stipčević, M.; Stolarczyk, Th.; Tareb-Reyes, M.; Taylor, G. N.; Tereshchenko, V.; Toropin, A.; Touchard, A.-M.; Tovey, S. N.; Tran, M.-T.; Tsesmelis, E.; Ulrichs, J.; Vacavant, L.; Valdata-Nappi, M.; Valuev, V.; Vannucci, F.; Varvell, K. E.; Veltri, M.; Vercesi, V.; Vidal-Sitjes, G.; Vieira, J.-M.; Vinogradova, T.; Weber, F. V.; Weisse, T.; Wilson, F. F.; Winton, L. J.; Wu, Q.; Yabsley, B. D.; Zaccone, H.; Zuber, K.; Zuccon, P.

    2009-11-01

    We present a study of exclusive neutral pion production in neutrino-nucleus Neutral Current interactions using data from the NOMAD experiment at the CERN SPS. The data correspond to 1.44 ×106 muon-neutrino Charged Current interactions in the energy range 2.5 ⩽Eν ⩽ 300 GeV. Neutrino events with only one visible π0 in the final state are expected to result from two Neutral Current processes: coherent π0 production, ν + A → ν + A +π0 and single π0 production in neutrino-nucleon scattering. The signature of coherent π0 production is an emergent π0 almost collinear with the incident neutrino while π0's produced in neutrino-nucleon deep inelastic scattering have larger transverse momenta. In this analysis all relevant backgrounds to the coherent π0 production signal are measured using data themselves. Having determined the backgrounds, and using the Rein-Sehgal model for the coherent π0 production to compute the detection efficiency, we obtain 4630 ± 522 (stat) ± 426 (syst) corrected coherent-π0 events with Eπ0 ⩾ 0.5 GeV. We measure σ (νA → νAπ0) = [ 72.6 ± 8.1 (stat) ± 6.9 (syst) ] ×10-40 cm2 /nucleus. This is the most precise measurement of the coherent π0 production to date.

  2. Filter-based Aerosol Measurement Experiments using Spherical Aerosol Particles under High Temperature and High Pressure

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Chan; Jung, Woo Young; Lee, Hyun Chul; Lee, Doo Young [FNC TECH., Yongin (Korea, Republic of)

    2016-05-15

    Optical Particle Counter (OPC) is used to provide real-time measurement of aerosol concentration and size distribution. Glass fiber membrane filter also be used to measure average mass concentration. Three tests (MTA-1, 2 and 3) have been conducted to study thermal-hydraulic effect, a filtering tendency at given SiO{sub 2} particles. Based on the experimental results, the experiment will be carried out further with a main carrier gas of steam and different aerosol size. The test results will provide representative behavior of the aerosols under various conditions. The aim of the tests, MTA 1, 2 and 3, are to be able to 1) establish the test manuals for aerosol generation, mixing, sampling and measurement system, which defines aerosol preparation, calibration, operating and evaluation method under high pressure and high temperature 2) develop commercial aerosol test modules applicable to the thermal power plant, environmental industry, automobile exhaust gas, chemical plant, HVAC system including nuclear power plant. Based on the test results, sampled aerosol particles in the filter indicate that important parameters affecting aerosol behavior aerosols are 1) system temperature to keep above a evaporation temperature of ethanol and 2) aerosol losses due to the settling by ethanol liquid droplet.

  3. Pose Measurement Method and Experiments for High-Speed Rolling Targets in a Wind Tunnel

    Directory of Open Access Journals (Sweden)

    Zhenyuan Jia

    2014-12-01

    Full Text Available High-precision wind tunnel simulation tests play an important role in aircraft design and manufacture. In this study, a high-speed pose vision measurement method is proposed for high-speed and rolling targets in a supersonic wind tunnel. To obtain images with high signal-to-noise ratio and avoid impacts on the aerodynamic shape of the rolling targets, a high-speed image acquisition method based on ultrathin retro-reflection markers is presented. Since markers are small-sized and some of them may be lost when the target is rolling, a novel markers layout with which markers are distributed evenly on the surface is proposed based on a spatial coding method to achieve highly accurate pose information. Additionally, a pose acquisition is carried out according to the mentioned markers layout after removing mismatching points by Case Deletion Diagnostics. Finally, experiments on measuring the pose parameters of high-speed targets in the laboratory and in a supersonic wind tunnel are conducted to verify the feasibility and effectiveness of the proposed method. Experimental results indicate that the position measurement precision is less than 0.16 mm, the pitching and yaw angle precision less than 0.132° and the roll angle precision 0.712°.

  4. Coherence Imaging Measurements of Impurity Flow in the CTH and W7-X Experiments

    Science.gov (United States)

    Ennis, D. A.; Allen, N. R.; Hartwell, G. J.; Johnson, C. A.; Maurer, D. A.; Allen, S. L.; Samuell, C. M.; Gradic, D.; Konig, R.; Perseo, V.; W7-X Team

    2017-10-01

    Measurements of impurity ion emissivity and velocity in the Compact Toroidal Hybrid (CTH) experiment are achieved with a new optical coherence imaging diagnostic. The Coherence Imaging Spectroscopy (CIS) technique uses an imaging interferometer of fixed delay to provide 2D spectral images, making it ideal for investigating the non-axisymmetric geometry of CTH plasmas. Preliminary analysis of C III interferograms indicate a net toroidal flow on the order of 10 km/s during the time of peak current. Bench tests using Zn and Cd light sources reveal that the temperature of the interferometer optics must be controlled to within 0.01°C to limit phase drift resulting in artificially measured flow. A new collaboration between Auburn University and the Max-Planck-Institute for Plasma Physics is underway to develop two new coherence imaging instruments for ion impurity flow measurements in orthogonal directions to investigate the 3D physics of the W7-X island divertor during OP1.2. A continuous wave laser tunable over most of the visible region will be incorporated to provide immediate and accurate calibrations of both CIS systems during plasma operations. Work supported by USDoE Grant DE-FG02-00ER54610.

  5. MICE: the Muon Ionization Cooling Experiment. Step I: First Measurement of Emittance with Particle Physics Detectors

    CERN Document Server

    Bravar, U; Karadzhov, Y; Kolev, D; Russinov, I; Tsenov, R; Wang, L; Xu, F Y; Zheng, S X; Bertoni, R; Bonesini, M; Mazza, R; Palladino, V; Cecchet, G; de Bari, A; Capponi, M; Iaciofano, A; Orestano, D; Pastore, F; Tortora, L; Ishimoto, S; Suzuki, S; Yoshimura, K; Mori, Y; Kuno, Y; Sakamoto, H; Sato, A; Yano, T; Yoshida, M; Filthaut, F; Vretenar, M; Ramberger, S; Blondel, A; Cadoux, F; Masciocchi, F; Graulich, J S; Verguilov, V; Wisting, H; Petitjean, C; Seviour, R; Ellis, M; Kyberd, P; Littlefield, M; Nebrensky, J J; Forrest, D; Soler, F J P; Walaron, K; Cooke, P; Gamet, R; Alecou, A; Apollonio, M; Barber, G; Dobbs, A; Dornan, P; Fish, A; Hare, R; Jamdagni, A; Kasey, V; Khaleeq, M; Long, K; Pasternak, J; Sakamoto, H; Sashalmi, T; Blackmore, V; Cobb, J; Lau, W; Rayner, M; Tunnell, C D; Witte, H; Yang, S; Alexander, J; Charnley, G; Griffiths, S; Martlew, B; Moss, A; Mullacrane, I; Oats, A; York, S; Apsimon, R; Alexander, R J; Barclay, P; Baynham, D E; Bradshaw, T W; Courthold, M; Hayler, R Edgecock T; Hills, M; Jones, T; McNubbin, N; Murray, W J; Nelson, C; Nicholls, A; Norton, P R; Prior, C; Rochford, J H; Rogers, C; Spensley, W; Tilley, K; Booth, C N; Hodgson, P; Nicholson, R; Overton, E; Robinson, M; Smith, P; Adey, D; Back, J; Boyd, S; Harrison, P; Norem, J; Bross, A D; Geer, S; Moretti, A; Neuffer, D; Popovic, M; Qian, Z; Raja, R; Stefanski, R; Cummings, M A C; Roberts, T J; DeMello, A; Green, M A; Li, D; Sessler, A M; Virostek, S; Zisman, M S; Freemire, B; Hanlet, P; Huang, D; Kafka, G; Kaplan, D M; Snopok, P; Torun, Y; Onel, Y; Cline, D; Lee, K; Fukui, Y; Yang, X; Rimmer, R A; Cremaldi, L M; Hart, T L; Summers, D J; Coney, L; Fletcher, R; Hanson, G G; Heidt, C; Gallardo, J; Kahn, S; Kirk, H; Palmer, R B; C11-08-09

    2011-01-01

    The Muon Ionization Cooling Experiment (MICE) is a strategic R&D project intended to demonstrate the only practical solution to providing high brilliance beams necessary for a neutrino factory or muon collider. MICE is under development at the Rutherford Appleton Laboratory (RAL) in the United Kingdom. It comprises a dedicated beamline to generate a range of input muon emittances and momenta, with time-of-flight and Cherenkov detectors to ensure a pure muon beam. The emittance of the incoming beam will be measured in the upstream magnetic spectrometer with a scintillating fiber tracker. A cooling cell will then follow, alternating energy loss in Liquid Hydrogen (LH2) absorbers to RF cavity acceleration. A second spectrometer, identical to the first, and a second muon identification system will measure the outgoing emittance. In the 2010 run at RAL the muon beamline and most detectors were fully commissioned and a first measurement of the emittance of the muon beam with particle physics (time-of-flight) de...

  6. ACADEMIC TRAINING: Low Energy Experiments that Measure Fundamental Constants and Test Basic Symmetries

    CERN Multimedia

    Françoise Benz

    2002-01-01

    17, 18, 19 , 21 June LECTURE SERIES from 11.00 to 12.00 hrs - Auditorium, bldg. 500 Low Energy Experiments that Measure Fundamental Constants and Test Basic Symmetries by G. GABRIELSE / Professor of Physics and Chair of the Harvard Physics Department, Spokesperson for the ATRAP Collaboration Lecture 1: Particle Traps: the World's Tiniest Accelerators A single elementary particle, or a single ion, can be confined in a tiny accelerator called a particle trap. A single electron was held this way for more than ten months, and antiprotons for months. Mass spectroscopy of exquisite precision is possible with such systems. CERN's TRAP Collaboration thereby compared the charge-to-mass ratios of the antiproton and proton to a precision of 90 parts per trillion, by far the most stringent CPT test done with a baryon system. The important ratio of the masses of the electron and proton have been similarly measured, as have a variety of ions masses, and the neutron mass is most accurately known from such measurements. An i...

  7. Two-wave photon Doppler velocimetry measurements in direct impact Hopkinson pressure bar experiments

    Directory of Open Access Journals (Sweden)

    Lea Lewis J.

    2015-01-01

    Full Text Available Direct impact Hopkinson pressure bar systems offer many potential advantages over split Hopkinson pressure bars, including access to higher strain rates, higher strains for equivalent striker velocity and system length, lower dispersion and faster achievement of force equilibrium. Currently advantages are gained at a significant cost: the fact that input bar data is unavailable removes all information about the striker impacted specimen face, preventing the determination of force equilibrium, and requiring approximations to be made on the sample deformation history. Recently photon Doppler velocimetry methods have been developed, which can replace strain gauges on Hopkinson bars. In this paper we discuss an experimental method and complementary data analysis for using Doppler velocimetry to measure surface velocities of the striker and output bars in a direct impact bar experiment, allowing similar data to be recorded as in a split bar system, with the same level of convenience. We discuss extracting velocity and force measurements, and improving the accuracy and convenience of Doppler velocimetry on Hopkinson bars. Results obtained using the technique are compared to equivalent split bar tests, showing improved stress measurements for the lowest and highest strains.

  8. NASA Cold Land Processes Experiment (CLPX 2002/03): Field measurements of snowpack properties and soil moisture

    Science.gov (United States)

    Kelly Elder; Don Cline; Glen E. Liston; Richard Armstrong

    2009-01-01

    A field measurement program was undertaken as part NASA's Cold Land Processes Experiment (CLPX). Extensive snowpack and soil measurements were taken at field sites in Colorado over four study periods during the two study years (2002 and 2003). Measurements included snow depth, density, temperature, grain type and size, surface wetness, surface roughness, and...

  9. Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids

    NARCIS (Netherlands)

    Lozovaya, N.; Yatsenko, N.; Beketov, A.; Tsintsadze, T.; Burnashev, N.

    2005-01-01

    At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit neurotransmitter release. Here, we demonstrate that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR)

  10. Disproportionation of hydrogen peroxide in the presence of coordination compounds of manganese (II) with glycine

    Energy Technology Data Exchange (ETDEWEB)

    Batyr, D.G.; Isak, V.G.; Kil' mininov, S.V.

    1988-01-01

    It has been established that the effective decomposition of hydrogen peroxide takes place in the presence of coordination compounds of manganese (II) with glycine (Gly). The catalytically active species is the complex (MnGly/sub 3/)/sup 2 +/.

  11. Augmenting in vitro osteogenesis of a glycine-arginine-glycine-aspartic-conjugated oxidized alginate-gelatin-biphasic calcium phosphate hydrogel composite and in vivo bone biogenesis through stem cell delivery.

    Science.gov (United States)

    Linh, Nguyen Tb; Paul, Kallyanashis; Kim, Boram; Lee, Byong-Taek

    2016-11-01

    A functionally modified peptide-conjugated hydrogel system was fabricated with oxidized alginate/gelatin loaded with biphasic calcium phosphate to improve its biocompatibility and functionality. Sodium alginate was treated by controlled oxidation to transform the cis-diol group into an aldehyde group in a controlled manner, which was then conjugated to the amine terminus of glycine-arginine-glycine-aspartic. Oxidized alginate glycine-arginine-glycine-aspartic was then combined with gelatin-loaded biphasic calcium phosphate to form a hydrogel of composite oxidized alginate/gelatin/biphasic calcium phosphate that displayed enhanced human adipose stem cell adhesion, spreading and differentiation. 1H nuclear magnetic resonance and electron spectroscopy for chemical analysis confirmed that the glycine-arginine-glycine-aspartic was successfully grafted to the oxidized alginate. Co-delivery of glycine-arginine-glycine-aspartic and human adipose stem cell in a hydrogel matrix was studied with the results indicating that hydrogel incorporated modified with glycine-arginine-glycine-aspartic and seeded with human adipose stem cell enhanced osteogenesis in vitro and bone formation in vivo. © The Author(s) 2016.

  12. Monetary and social impact measures of visitor experience and the effects of a piping plover recovery program on visitor experience

    Science.gov (United States)

    Laura Gilbert

    1995-01-01

    This study examined visitor perceptions and attitudes towards their experience at a national wildlife refuge which limits access to its barrier beach during the nesting season of the threatened piping plover. It determined attitudes towards the closure, as well as what factors influenced these attitudes. It also examined how willingness to pay for refuge protection...

  13. First Measurement of \\theta_13 from Delayed Neutron Capture on Hydrogen in the Double Chooz Experiment

    CERN Document Server

    Abe, Y; Anjos, J C dos; Barriere, J C; Bergevin, M; Bernstein, A; Bezerra, T J C; Bezrukhov, L; Blucher, E; Bowden, N S; Buck, C; Busenitz, J; Cabrera, A; Caden, E; Camilleri, L; Carr, R; Cerrada, M; Chang, P -J; Chimenti, P; Classen, T; Collin, A P; Conover, E; Conrad, J M; Crespo-Anadón, J I; Crum, K; Cucoanes, A; Damon, E; Dawson, J V; Dazeley, S; Dietrich, D; Djurcic, Z; Dracos, M; Durand, V; Ebert, J; Efremenko, Y; Elnimr, M; Erickson, A; Etenko, A; Fallot, M; Fechner, M; von Feilitzsch, F; Felde, J; Fernandes, S M; Fischer, V; Franco, D; Franke, A J; Franke, M; Furuta, H; Gama, R; Gil-Botella, I; Giot, L; Göger-Neff, M; Gonzalez, L F G; Goodenough, L; Goodman, M C; Goon, J TM; Greiner, D; Haag, N; Habib, S; Hagner, C; Hara, T; Hartmann, F X; Haser, J; Hatzikoutelis, A; Hayakawa, T; Hofmann, M; Horton-Smith, G A; Hourlier, A; Ishitsuka, M; Jochum, J; Jollet, C; Jones, C L; Kaether, F; Kalousis, L N; Kamyshkov, Y; Kaplan, D M; Kawasaki, T; Keefer, G; Kemp, E; de Kerret, H; Konno, T; Kryn, D; Kuze, M; Lachenmaier, T; Lane, C E; Langbrandtner, C; Lasserre, T; Letourneau, A; Lhuillier, D; Lima, H P; Lindner, M; López-Castaño, J M; LoSecco, J M; Lubsandorzhiev, B K; Lucht, S; McKee, D; Maeda, J; Maesano, C N; Mariani, C; Maricic, J; Martino, J; Matsubara, T; Mention, G; Meregaglia, A; Meyer, M; Miletic, T; Milincic, R; Miyata, H; Mueller, Th A; Nagasaka, Y; Nakajima, K; Novella, P; Obolensky, M; Oberauer, L; Onillon, A; Osborn, A; Ostrovskiy, I; Palomares, C; Pepe, I M; Perasso, S; Perrin, P; Pfahler, P; Porta, A; Potzel, W; Pronost, G; Reichenbacher, J; Reinhold, B; Remoto, A; Röhling, M; Roncin, R; Roth, S; Rybolt, B; Sakamoto, Y; Santorelli, R; Sato, F; Schönert, S; Schoppmann, S; Schwetz, T; Shaevitz, M H; Shimojima, S; Shrestha, D; Sida, J-L; Sinev, V; Skorokhvatov, M; Smith, E; Spitz, J; Stahl, A; Stancu, I; Stokes, L F F; Strait, M; Stüken, A; Suekane, F; Sukhotin, S; Sumiyoshi, T; Sun, Y; Svoboda, R; Terao, K; Tonazzo, A; Toups, M; Thi, H H Trinh; Valdiviesso, G; Veyssiere, C; Wagner, S; Watanabe, H; White, B; Wiebusch, C; Winslow, L; Worcester, M; Wurm, M; Yermia, F; Zimmer, V

    2013-01-01

    The Double Chooz experiment has determined the value of the neutrino oscillation parameter $\\theta_{13}$ from an analysis of inverse beta decay interactions with neutron capture on hydrogen. This analysis uses a three times larger fiducial volume than the standard Double Chooz assessment, which is restricted to a region doped with gadolinium (Gd), yielding an exposure of 113.1 GW-ton-years. The data sample used in this analysis is distinct from that of the Gd analysis, and the systematic uncertainties are also largely independent, with some exceptions, such as the reactor neutrino flux prediction. A combined rate- and energy-dependent fit finds $\\sin^2 2\\theta_{13}=0.097\\pm 0.034(stat.) \\pm 0.034 (syst.)$, excluding the no-oscillation hypothesis at 2.0 \\sigma. This result is consistent with previous measurements of $\\sin^2 2\\theta_{13}$.

  14. The ISPM experiment for spectral, composition and anistropy measurements of charged particles at low energie

    Science.gov (United States)

    Lanzerotti, L. J.; Gold, R. E.; Anderson, K. A.; Armstrong, T. P.; Lin, R. P.; Krimigis, S. M.; Pick, M.; Roelof, E. C.; Sarris, E. T.; Simnett, G. M.

    1983-01-01

    The Heliosphere Instrument for Spectral, Composition, and Anisotropy at Low Energies (HI-SCALE) designed to measure interplanetary ions and electrons is described. Ions and electrons are detected by five separate solid-state detector telescopes oriented to give complete pitch angle coverage from the spinning spacecraft. Ion elemental abundances are determined by a telescope using a thin front detector element in a three-element telescope. Experiment operation is controlled by a microprocessor-based data system. Inflight calibration is provided by radioactive sources mounted on closable telescope covers. Ion and electron spectral information is determined using broad-energy-range rate channels, and a pulse-height analyzer for more detailed spectra. The instrument weighs 5.775 kg and uses 4.0 W power.

  15. Musical experience, plasticity, and maturation: issues in measuring developmental change using EEG and MEG.

    Science.gov (United States)

    Trainor, Laurel J

    2012-04-01

    The neuroscientific study of musical behavior has become a significant field of research during the last decade, and reports of this research in the popular press have caught the imagination of the public. This enterprise has also made it evident that studying the development of musical behavior can make a significant contribution to important questions in the field, such as the evolutionary origins of music, cross-cultural similarity and diversity, the effects of experience on musical processing, and relations between music and other domains. Studying musical development brings a unique set of methodological issues. We discuss a select set of these related to measurement of the electroencephalogram (EEG) and magnetoencephalogram (MEG). We use specific examples from our laboratory to illustrate the types of questions that can be answered with different data analysis techniques. © 2012 New York Academy of Sciences.

  16. Boundary Layer Transition Flight Experiment Overview and In-Situ Measurements

    Science.gov (United States)

    Berger, Karen T.; Anderson, Brian P.; Campbell, Charles H.; Garske, Michael T.; Saucedo, Luis A.; Kinder, Gerald R.

    2010-01-01

    In support of the Boundary Layer Transition Flight Experiment (BLT FE) Project, a manufactured protuberance tile was installed on the port wing of Space Shuttle Orbiter Discovery for the flights of STS-119, STS-128 and STS-131. Additional instrumentation was installed in order to obtain more spatially resolved measurements downstream of the protuberance. This paper provides an overview of the BLT FE Project. Significant efforts were made to place the protuberance at an appropriate location on the Orbiter and to design the protuberance to withstand the expected environments. A high-level overview of the in-situ flight data is presented, along with a summary of the comparisons between pre- and post-flight analysis predictions and flight data. Comparisons show that predictions for boundary layer transition onset time closely match the flight data, while predicted temperatures were significantly higher than observed flight temperatures.

  17. aCORN: An experiment to measure the electron-antineutrino correlation in neutron decay

    Energy Technology Data Exchange (ETDEWEB)

    Wietfeldt, F.E., E-mail: few@tulane.ed [Department of Physics, Tulane University, New Orleans, LA 70118 (United States); Byrne, J. [University of Sussex (United Kingdom); Collett, B. [Physics Department, Hamilton College, Clinton, NY 13323 (United States); Dewey, M.S. [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Jones, G.L. [Physics Department, Hamilton College, Clinton, NY 13323 (United States); Komives, A. [Physics Department, DePauw University, Greencastle, IN 46135 (United States); Laptev, A. [Department of Physics, Tulane University, New Orleans, LA 70118 (United States); Nico, J.S. [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Noid, G.; Stephenson, E.J. [Indiana University Cyclotron Facility, Bloomington, IN 47408 (United States); Stern, I.; Trull, C. [Department of Physics, Tulane University, New Orleans, LA 70118 (United States); Yerozolimsky, B.G. [Physics Department, Harvard University, Cambridge, MA 02139 (United States)

    2009-12-11

    The aCORN experiment is designed to make a precision (<1%) measurement of the electron-antineutrino angular correlation (a-coefficient) in neutron beta decay. It uses a new method proposed in 1996 by Yerozolimsky and Mostovoy. Electrons and recoil protons from neutron decay in a cold beam are detected in coincidence. The momenta of the particles are selected so that the protons form two kinematically distinct time-of-flight groups as a function of electron energy. The count rate asymmetry in these two groups is proportional to the a-coefficient. Precision spectroscopy of the protons is not required. The apparatus is currently under construction. It will be integrated and tested at the Indiana University Cyclotron Facility (IUCF) and then moved to the NIST Center for Neutron Research for the initial physics run.

  18. Cloning of a Putative Pectate Lyase Gene Expressed in the Subventral Esophageal Glands of Heterodera glycines.

    Science.gov (United States)

    De Boer, J M; Davis, E L; Hussey, R S; Popeijus, H; Smant, G; Baum, T J

    2002-03-01

    We report the cloning of a Heterodera glycines cDNA that has 72% identity at the amino acid level to a pectate lyase from Globodera rostochiensis. In situ hybridizations showed that the corresponding gene (Hg-pel-1) is expressed in the subventral esophageal gland cells of second-stage juveniles. The deduced amino acid sequence of the H. glycines cDNA shows homology to class III pectate lyases of bacterial and fungal origin.

  19. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.

    Science.gov (United States)

    Cruz, M; Maldonado-Bernal, C; Mondragón-Gonzalez, R; Sanchez-Barrera, R; Wacher, N H; Carvajal-Sandoval, G; Kumate, J

    2008-08-01

    Amino acids have been shown to stimulate insulin secretion and decrease glycated hemoglobin (A1C) in patients with Type 2 diabetes. In vitro, glycine reduces tumor necrosis factor (TNF)-alpha secretion and increases interleukin-10 secretion in human monocytes stimulated with lipopolysaccharide. The aim of this study was to determine whether glycine modifies the proinflammatory profiles of patients with Type 2 diabetes. Seventy-four patients, with Type 2 diabetes were enrolled in the study. The mean age was 58.5 yr, average age of diagnosis was 5 yr, the mean body mass index was 28.5 kg/m2, the mean fasting glucose level was 175.5 mg/dl and the mean A1C level was 8%. They were allocated to one of two treatments, 5 g/d glycine or 5 g/d placebo, po tid, for 3 months. A1C levels of patients given glycine were significantly lower after 3 months of treatment than those of the placebo group. A significant reduction in TNF-receptor I levels was observed in patients given glycine compared with placebo. There was a decrease of 38% in the interferon (IFN)-gamma level of the group treated with placebo, whereas that of the group treated with glycine increased up to 43%. These data showed that patients treated with glycine had a significant decrease in A1C and in proinflammatory cytokines and also an important increase of IFN-gamma. Treatment with glycine is likely to have a beneficial effect on innate and adaptive immune responses and may help prevent tissue damage caused by chronic inflammation in patients with Type 2 diabetes.

  20. Effect of zinc acetate addition on crystal growth, structural, optical, thermal properties of glycine single crystals

    Directory of Open Access Journals (Sweden)

    S. Anbu Chudar Azhagan

    2017-05-01

    Full Text Available In the present study, γ-glycine has been crystallized by using zinc acetate dihydrate as an additive for the first time by slow solvent evaporation method. The second harmonic conversion efficiency of γ-glycine crystal was determined using Kurtz and Perry powder technique and was found to be 3.66 times greater than that of standard inorganic material potassium dihydrogen phosphate (KDP. The analytical grade chemicals of glycine and zinc acetate dihydrate were taken in six different molar ratios: 1:0.2, 1:0.4, 1:0.6, 1:0.7, 1:0.8, and 1:0.9 respectively to find out the γ-polymorph of glycine. The lower molar concentration of zinc acetate yield only α-polymorph where as the higher molar concentration of zinc acetate inhibits the γ-polymorph of glycine which was confirmed by single crystal XRD and powder XRD studies. Inductively coupled plasma optical emission spectrometry (ICP-OES was carried out to quantify the concentration of zinc element in the grown glycine single crystals. The concentration of zinc element in the presence of grown γ-glycine single crystal is found to be 0.73 ppm. UV–Visible–NIR transmittance spectra were recorded for the samples to analyse the transparency in visible and near infrared region (NIR. The optical band gap Eg was estimated for γ-glycine single crystal using UV–Visible–NIR study. Functional groups present in the samples were identified by FTIR spectroscopic analysis. Differential scanning calorimetry technique was employed to determine the phase transition, thermal stability and melting point of the grown crystal.