Biallelic inactivation of REV7 is associated with Fanconi anemia.

Science.gov (United States)

Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean

2016-09-01

Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

Science.gov (United States)

Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

2017-02-01

HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

REV7, a new gene concerned with UV mutagenesis in yeast

International Nuclear Information System (INIS)

Lawrence, C.W.; Das, G.; Christensen, R.B.

1985-01-01

Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. Rev7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX. (orig.)

REV7, a new gene concerned with UV mutagenesis in yeast

Energy Technology Data Exchange (ETDEWEB)

Lawrence, C.W.; Das, G.; Christensen, R.B.

1985-06-26

Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. REV7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX.

Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

Energy Technology Data Exchange (ETDEWEB)

Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

2005-12-15

The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

Sampling and estimation techniques for the implementation of new classification systems: the change-over from NACE Rev. 1.1 to NACE Rev. 2 in business surveys

Directory of Open Access Journals (Sweden)

Jan van den Brakel

2010-09-01

Full Text Available This paper describes some of the methodological problems encountered with the change-over from the NACE Rev. 1.1 to the NACE Rev. 2 in business statistics. Different sampling and estimation strategies are proposed to produce reliable figures for the domains under both classifications simultaneously. Furthermore several methods are described that can be used to reconstruct time series for the domains under the NACE Rev. 2.

TÜREV ÜRÜNLERİN MUHASEBELEŞTİRİLMESİ

OpenAIRE

YURT, Eda

2009-01-01

Eda, Yurt, Türev Ürünlerin Muhasebelestirilmesi, Tezsiz Yüksek Lisans Dönem Projesi,Danısman: Doç. Dr. Kadir Gürdal, 58 s.BİTİRME PROJESİ ÖZETİProje finansal araçlar olarak türev ürünlerin muhasebelestirilmesine iliskinstandartların incelenmesini amaçlamaktadır. Öncelikle finansal risk tanımlanmıstır.Daha sonra türev piyasaların tarihi anlatılmıs ve islem gördükleri piyasalara göresınıflandırılmıstır. Bu temel açıklamalar sonrasında türev ürünler için UluslararasıMuhasebe Standartları incelen...

Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas

Science.gov (United States)

New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center

A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev

International Nuclear Information System (INIS)

Fang Jianhua; Kubota, Satoshi; Yang Bin; Zhou Naiming; Zhang Hui; Godbout, Roseline; Pomerantz, Roger J.

2004-01-01

HIV-1 Rev escorts unspliced viral mRNAs out of the nucleus of infected cells, which allows formation of infectious HIV-1 virions. We have identified a putative DEAD box (Asp-Glu-Ala-Asp) RNA helicase, DDX1, as a cellular co-factor of Rev, through yeast and mammalian two-hybrid systems using the N-terminal motif of Rev as 'bait'. DDX1 is not a functional homolog of HIV-1 Rev, but down-regulation of DDX1 resulted in an alternative splicing pattern of Rev-responsive element (RRE)-containing mRNA, and attenuation of Gag p24 antigen production from HLfb rev(-) cells rescued by exogenous Rev. Co-transfection of a DDX1 expression vector with HIV-1 significantly increased viral production. DDX1 binding to Rev, as well as to the RRE, strongly suggest that DDX1 affects Rev function through the Rev-RRE axis. Moreover, down-regulation of DDX1 altered the steady state subcellular distribution of Rev, from nuclear/nucleolar to cytoplasmic dominance. These findings indicate that DDX1 is a critical cellular co-factor for Rev function, which maintains the proper subcellular distribution of this lentiviral regulatory protein. Therefore, alterations in DDX1-Rev interactions could induce HIV-1 persistence and targeting DDX1 may lead to rationally designed and novel anti-HIV-1 strategies and therapeutics

Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.

Science.gov (United States)

Bogerd, H P; Wiegand, H L; Yang, J; Cullen, B R

2000-10-01

Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the approximately 25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.

Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

CERN Multimedia

HR Department

2008-01-01

Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

CERN Document Server

HR Department

2008-01-01

Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

SEM-REV: A sea test site for Marine Energy Converter

International Nuclear Information System (INIS)

Berhault, Christian; Le Crom, Izan; Le Bihan, Gerard

2015-01-01

Thanks to a main funding of Region des Pays de la Loire, the sea test site SEM-REV has been developed by Ecole Centrale de Nantes since 2007 to test both Wave Energy Converters and Floating Wind Turbine in real sea conditions. The sea test site is equipped with a set of oceanographic sensors and with an electric cable of 8 MW, connected to the French grid. The project is located close to Le Croisic, Western coast of France. SEM-REV is one of the main test facilities operated by Ecole Centrale de Nantes to support MRE technologies development. After presenting the initial motivations of the SEM-REV development, the paper describes, in parts 1 and 2, the complete administrative and technical processes that were followed to reach SEM-REV commissioning in 2014. The third part is focused on the exploitation process, including technical and contractual specifications imposed to the MRE developers for installation, tests and decommissioning phases. Some words are given also on the R and D projects using the SEM-REV in-situ monitoring system: prediction of environmental conditions, bio-fooling, acoustic impact. Even if operational phase is not started, expected extensions of the tests site are listed. (authors)

Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

Directory of Open Access Journals (Sweden)

St-Laurent Georges

2006-11-01

Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells

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Kouichi Yamada

2011-11-01

Full Text Available When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS into two types. In human cancer cells or xeroderma pigmentosum variant (XP-V cells, UV-TLS was inhibited by caffeine or proteasome inhibitors. However, in normal human cells, the process was insensitive to these reagents. Reportedly, in yeast or mammalian cells, REV3 protein (a catalytic subunit of DNA polymerase ζ is predominantly involved in the former type of TLS. Here, we studied UV-TLS in fibroblasts derived from the Rev3-knockout mouse embryo (Rev3KO-MEF. In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells, and was abolished by caffeine or MG-262. In 2 cell lines of Rev3KO-MEF (Rev3−/− p53−/−, UV-TLS was not observed. In p53KO-MEF, which is a strict control for Rev3KO-MEF, the UV-TLS response was similar to that of the wild-type. Introduction of the Rev3 expression plasmid into Rev3KO-MEF restored the UV-TLS response in selected stable transformants. In some transformants, viability to UV was the same as that in the wild-type, and the death rate was increased by caffeine. Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.

REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

Directory of Open Access Journals (Sweden)

Gwendal Le Martelot

2009-09-01

Full Text Available In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regulatory proteins, such as the orphan receptor REV-ERBalpha. Circadian transcription factors then drive daily rhythms in the expression of clock-controlled output genes, for example genes encoding enzymes and regulators of cellular metabolism. To gain insight into clock output functions of REV-ERBalpha, we carried out genome-wide transcriptome profiling experiments with liver RNA from wild-type mice, Rev-erbalpha knock-out mice, or REV-ERBalpha overexpressing mice. On the basis of these genetic loss- and gain-of-function experiments, we concluded that REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP activity, and thereby in the daily expression of SREBP target genes involved in cholesterol and lipid metabolism. This control is exerted via the cyclic transcription of Insig2, encoding a trans-membrane protein that sequesters SREBP proteins to the endoplasmic reticulum membranes and thereby interferes with the proteolytic activation of SREBPs in Golgi membranes. REV-ERBalpha also participates in the cyclic expression of cholesterol-7alpha-hydroxylase (CYP7A1, the rate-limiting enzyme in converting cholesterol to bile acids. Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols. In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry.

Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

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Thomas Vercruysse

Full Text Available HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190 as the first inhibitor targeting the Rev multimerization function in cells. This nanobody is a potent intracellular antibody that efficiently inhibits HIV-1 viral production. In order to gain insight into the Nb190-Rev interaction interface, we performed mutational and docking studies to map the interface between the nanobody paratope and the Rev epitope. Alanine mutants of the hyper-variable domains of Nb190 and the Rev multimerization domains were evaluated in different assays measuring Nb190-Rev interaction or viral production. Seven residues within Nb190 and five Rev residues are demonstrated to be crucial for epitope recognition. These experimental data were used to perform docking experiments and map the Nb190-Rev structural interface. This Nb190-Rev interaction model can guide further studies of the Nb190 effect on HIV-1 Rev function and could serve as starting point for the rational development of smaller entities binding to the Nb190 epitope, aimed at interfering with protein-protein interactions of the Rev N-terminal domain.

Applications of the INFCIRC225/rev5 to the national physical protection regime

International Nuclear Information System (INIS)

Kim, Jae Gwang

2011-01-01

The IAEA's first effort for playing a key role in physical protection of nuclear material and facilities resulted in the publication of 'Recommendations for the physical protection of nuclear material' in 1972. These recommendations were revised by a group of experts in co-operation with the IAEA Secretariat and the revised version was published in 1975 in INFCIRC/225. The document was subsequently revised in 1977(rev.1), 1989(rev.2), in 1993(rev.3) and 1998(rev4). The Physical Protection regime in ROK has been established on the basis of INFCIRC225 rev4 since 2004 IAEA recently published The INFCIRC 225 rev5 through the 2 years expert consultations. The publication recommended 12 nuclear security fundamentals and requirements of physical protection of nuclear material and nuclear facility to the member states. This paper suggests the several applications to the national physical protection system from the 12 fundamentals and the requirements

Administrative Circular N° 26 (Rev.  5) - November 2004

CERN Multimedia

Human Resources Department

2004-01-01

Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

Türev piyasaları ve vergilendirilmesi

OpenAIRE

İşler, İsmail; Utku, Mehmet

2015-01-01

Türev piyasaları kavramı, vadeli işlem sözleşmeleri (forward, futures), opsiyon sözleşmeleri, swap sözleşmeleri ve aracı kuruluş varantları işlemlerinin tamamını içermektedir. Bu tür işlemler vadeli işlemlerdir. Vadeli işlemlerin ortak özelliği, ilerideki bir tarihte teslimatı yapılmak üzere herhangi bir malın veya finansal aracın, bugünden alım satımının yapılmasıdır. Bu çalışmada türev araçların tanımları ve vergilendirilmeleri örneklerle açıklanacaktır. The term derivatives market invol...

Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

Energy Technology Data Exchange (ETDEWEB)

Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

2009-10-30

The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

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HR Department

2008-01-01

Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

CERN Multimedia

HR Department

2008-01-01

Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

Directory of Open Access Journals (Sweden)

Min-Hsuan Lin

Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

Science.gov (United States)

Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

2017-09-16

Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

Contributions of individual domains to function of the HIV-1 Rev response element.

Science.gov (United States)

O'Carroll, Ina P; Thappeta, Yashna; Fan, Lixin; Ramirez-Valdez, Edric A; Smith, Sean; Wang, Yun-Xing; Rein, Alan

2017-08-16

The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additional domains. We previously reported that the RRE assumes an "A" shape in solution and suggested that the location of the Rev binding sites in domains I and II, opposite each other on the two legs of the A, is optimal for Rev binding and explains Rev's specificity for RRE-containing RNAs. Using SAXS and a quantitative functional assay, we have now analyzed a panel of RRE mutants. All the results support the essential role of the A shape for RRE function. Moreover, they suggest that the distal portion of domain I and the three crowning domains all contribute to the maintenance of the A shape. Domains I and II are necessary and sufficient for substantial RRE function, provided they are joined by a flexible linker that allows the two domains to face each other. IMPORTANCE Retroviral replication requires that some of the viral RNAs transcribed in the cell nucleus be exported to the cytoplasm without being spliced. To achieve this, HIV-1 encodes a protein, Rev, which binds to a complex, highly structured element within viral RNA, the Rev Response Element (RRE), and escorts RRE-containing RNAs from the nucleus. We previously reported that the RRE is "A"-shaped and suggested that this architecture, with the 2 legs opposite one another, can explain the specificity of Rev for the RRE. We have analyzed the functional contributions of individual RRE domains, and now report that several domains contribute, with some redundancy, to maintenance of the overall RRE shape. The data strongly support the hypothesis that the opposed placement of the 2 legs is essential for RRE function. Copyright © 2017

Administrative Circular No. 26 (Rev. 7) – May 2007

CERN Multimedia

HR Department

2007-01-01

Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

TEN YEARS OF THE NORTHEASTERN NURSING NETWORK JOURNAL - REV RENE: A DREAM COME TRUE

Directory of Open Access Journals (Sweden)

Inacia Sátiro Xavier de Franca

2011-01-01

Full Text Available Objetivou-se analisar a memória histórica da Rev Rene ao longo de uma década de sua existência destacando a sua organização, a produção científica e as conquistas alcançadas no concernente a sua indexação nas bases de dados. Estudo fenomenológico cujos dados foram coletados por meio de um formulário, submetidos a associações livres e interpretados em consonância com “A poética do espaço”. Os núcleos foram: Universidade Federal do Ceará (UFC — A casa da Rev Rene; A Rev Rene — ninho — um espaço aberto aos pesquisadores da Saúde e áreas afins; Poética das gavetas do cofre e dos armários — o capital científico da Rev Rene à disposição dos leitores; A Rev Rene — concha — uma homologia poética; A Rev Rene é redonda — Metas e ações para a projeção no cenário nacional e internacional. A Rev Rene transpôs a dimensão do sonho e consolidou-se como um lócus de ciência.

REV-ERB and ROR: therapeutic targets for treating myopathies

Science.gov (United States)

Welch, Ryan D.; Flaveny, Colin A.

2017-08-01

Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect. Skeletal muscle is also a vital secretory organ that regulates thermogenesis, inflammatory signaling and directs context specific global metabolic changes in energy substrate preference on a daily basis. Myopathies differ in the causative factors that drive them but share common features including severe reduction in quality of life and significantly increased mortality all due irrefutably to the loss of muscle mass. Thus far clinically viable approaches for preserving muscle proteins and stimulating new muscle growth without unwanted side effects or limited efficacy has been elusive. Over the last few decades, evidence has emerged through in vitro and in vivo studies that suggest the nuclear receptors REV-ERB and ROR might modulate pathways involved in myogenesis and mitochondrial biogenesis. Hinting that REV-ERB and ROR might be targeted to treat myopathies. However there is still a need for substantial investigation into the roles of these nuclear receptors in in vivo rodent models of degenerative muscle diseases and acute injury. Although exciting, REV-ERB and ROR have somewhat confounding roles in muscle physiology and therefore more studies utilizing in vivo models of skeletal muscle myopathies are needed. In this review we highlight the molecular forces driving some of the major degenerative muscular diseases and showcase two promising molecular targets that may have the potential to treat myopathies: ROR and REV-ERB.

Determining the REV for Fracture Rock Mass Based on Seepage Theory

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Lili Zhang

2017-01-01

Full Text Available Seepage problems of the fractured rock mass have always been a heated topic within hydrogeology and engineering geology. The equivalent porous medium model method is the main method in the study of the seepage of the fractured rock mass and its engineering application. The key to the method is to determine a representative elementary volume (REV. The FractureToKarst software, that is, discrete element software, is a main analysis tool in this paper and developed by a number of authors. According to the standard of rock classification established by ISRM, this paper aims to discuss the existence and the size of REV of fractured rock masses with medium tractility and provide a general method to determine the existence of REV. It can be gleaned from the study that the existence condition of fractured rock mass with medium tractility features average fracture spacing smaller than 0.6 m. If average fracture spacing is larger than 0.6 m, there is no existence of REV. The rationality of the model is verified by a case study. The present research provides a method for the simulation of seepage field in fissured rocks.

Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

Science.gov (United States)

Sail, Vibhavari; Rizzo, Alessandro A; Chatterjee, Nimrat; Dash, Radha C; Ozen, Zuleyha; Walker, Graham C; Korzhnev, Dmitry M; Hadden, M Kyle

2017-07-21

Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anticancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. The TLS DNA polymerase Rev1 serves as an integral scaffolding protein that mediates the assembly of the active multiprotein TLS complexes. Protein-protein interactions (PPIs) between the C-terminal domain of Rev1 (Rev1-CT) and the Rev1-interacting region (RIR) of other TLS DNA polymerases play an essential role in regulating TLS activity. To probe whether disrupting the Rev1-CT/RIR PPI is a valid approach for developing a new class of targeted anticancer agents, we designed a fluorescence polarization-based assay that was utilized in a pilot screen for small molecule inhibitors of this PPI. Two small molecule scaffolds that disrupt this interaction were identified, and secondary validation assays confirmed that compound 5 binds to Rev1-CT at the RIR interface. Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.

Status report of seabird surveys at Horns Rev, 2000-2001

International Nuclear Information System (INIS)

Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

2002-01-01

The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

International Nuclear Information System (INIS)

Kula, Anna; Gharu, Lavina; Marcello, Alessandro

2013-01-01

Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

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Hong Zan

2012-11-01

Full Text Available By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID-mediated deoxycytosine deamination, yielding deoxyuridine (dU, and dU glycosylation by uracil DNA glycosylase (Ung in antibody switch (S region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1−/− Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation, and CSR. Together with an S region spectrum of mutations similar to that of Rev1+/+ Ung−/− B cells, this suggests that Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1−/− Msh2−/− B cells. Rescue of CSR in Rev1−/− B cells by a catalytically inactive Rev1 mutant shows that the important role of Rev1 in CSR is mediated by Rev1’s scaffolding function, not its enzymatic function.

B23/nucleophosmin interacts with bovine immunodeficiency virus Rev protein and facilitates viral replication.

Science.gov (United States)

Passos-Castilho, Ana Maria; Marchand, Claude; Archambault, Denis

2018-02-01

The bovine immunodeficiency virus (BIV) Rev shuttling protein contains nuclear/nucleolar localization signals and nuclear import/export mechanisms that are novel among lentivirus Rev proteins. Several viral proteins localize to the nucleolus, which may play a role in processes that are essential to the outcome of viral replication. Although BIV Rev localizes to the nucleoli of transfected/infected cells and colocalizes with one of its major proteins, nucleophosmin (NPM1, also known as B23), the role of the nucleolus and B23 in BIV replication remains to be determined. Here, we demonstrate for the first time that BIV Rev interacts with nucleolar phosphoprotein B23 in cells. Using small interfering RNA (siRNA) technology, we show that depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication. The interaction between Rev and B23 may represent a potential new target for the development of antiviral drugs against lentiviruses. Copyright © 2017 Elsevier Inc. All rights reserved.

Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

CERN Multimedia

2012-01-01

Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast.

Science.gov (United States)

Lawrence, C W; O'Brien, T; Bond, J

1984-01-01

The UV-induced reversion of two his4 frameshift alleles was much reduced in rad6 mutants of Saccharomyces cerevisiae, an observation that is consistent with the hypothesis that RAD6 function is required for the induction of all types of genetic alteration in misrepair mutagenesis. The reversion of these his4 alleles, together with two others of the same type, was also reduced in rev1 and rev3 mutant strains; in these, however, the extent of the reduction varied considerably with test allele used, in a manner analogous to the results in these strains for base repair substitution test alleles. The general features of UV-induced frameshift and substitution mutagenesis therefore appear quite similar, indicating that they may depend on related processes. If this conclusion is correct, greater attention must be given to integrating models which account for the production of nucleotide additions and deletions into those concerning misrepair mutagenesis.

Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

Directory of Open Access Journals (Sweden)

Ryan D. Welch

2017-07-01

Conclusions: Disrupting Rev-Erb activity in injured muscle accelerates regenerative muscle repair/differentiation through transcriptional de-repression of myogenic programs. Rev-Erb, therefore, may be a potent therapeutic target for a myriad of muscular disorders.

Repository Surface Design Engineering Files Report Rev 00 ICN 1

International Nuclear Information System (INIS)

2001-01-01

The objective of the Repository Surface Design Engineering Files Report Supplement [herein known as the Engineering Files (EF)] is to provide the surface design data needed by the Environmental Impact Statement (EIS) contractor to prepare the EIS and evaluate options and alternatives. This document is based on the Repository Surface Design Engineering Files Report, Revision 03 (CRWMS M and O 1999f) (EF Rev 03). Where facility and system designs have been changed for the Site Recommendation (SR) effort they are described in this report. EIS information provided in this report includes the following: (1) Description of program phases; there are no changes that impact this report. (2) A description of the major design requirements and assumptions that drive the surface facilities reference design is provided herein (Section 2.2), including the surface design resulting from recommendations regarding Enhanced Design Alternative (EDA) II, as discussed in the License Application Design Section Report (CRWMS M and O 1999d), and changes to the waste stream. See Section 2, Table 2-2, for the SR waste stream. (3) The major design requirements and assumptions that drive the surface facilities reference design are by reference to EF Rev 03; there are no changes that impact this report. (4) Description of the reference design concept and existing site conditions is by reference to EF Rev 03 (including Table 4-1, which is not included in this supplement); there are no changes that impact this report. (5) Description of alternative design cases is by reference to EF Rev 03; there are no changes that impact this report. (6) Description of optional inventory modules is by reference to EF Rev 03; there are no changes that impact this report. (7) Tabular summary level engineering values (i.e., staffing, wastes, emissions, resources, and land use) for the reference design and the alternative design cases that address construction, emplacement operations, caretaker operations, and

Operational circular No. 1 (Rev. 1) – Operational circulars

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HR Department

2011-01-01

Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

Administrative Circular No. 23 (Rev. 4) - Special working hours

CERN Document Server

Department Head Office - HR Department

2016-01-01

Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

International Nuclear Information System (INIS)

Fang Jianhua; Acheampong, Edward; Dave, Rajnish; Wang Fengxiang; Mukhtar, Muhammad; Pomerantz, Roger J.

2005-01-01

Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

Mining the Human Complexome Database Identifies RBM14 as an XPO1-Associated Protein Involved in HIV-1 Rev Function

OpenAIRE

Budhiraja, Sona; Liu, Hongbing; Couturier, Jacob; Malovannaya, Anna; Qin, Jun; Lewis, Dorothy E.; Rice, Andrew P.

2015-01-01

By recruiting the host protein XPO1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts. We mined data from the recently described human nuclear complexome to identify a host protein, RBM14, which associates with XPO1 and Rev and is involved in Rev function. Using a Rev-dependent p24 reporter plasmid, we found that RBM14 depletion decreased Rev activity and Rev-mediated enhancement of the cytoplasmic levels of unspliced viral transcripts. RBM14 ...

Finanšu pārskata revīzijas process lielai sabiedrībai

OpenAIRE

Špoģe, Sarmīte

2018-01-01

Finanšu pārskata revīzijas process ir svarīgs temats, jo pirmreizēji revidētiem uzņēmumiem tiek atklātas būtiskas neatbilstības grāmatvedības uzskaitē, tās atbilstībai LR likumiem un normatīvajiem aktiem, kā arī finanšu pārskata sagatavošanā. Darba mērķis: apkopot un analizēt finanšu pārskata revīzijas procesu lielā sabiedrībā, noteikt revīzijas riskus, izstrādāt priekšlikumus revīzijas procesa uzlabošanai. Izvirzīto mērķu sasniegšanai autore pētīja un apkopoja informāciju par finanšu pārska...

Study on the REV Size of Fractured Rock in the Non-Darcy Flow Based on the Dual-Porosity Model

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Yuan Wang

2018-01-01

Full Text Available For the problem of whether the representative elementary volume (REV obtained in the Darcy flow is also applicable to the case of the non-Darcy flow, the study on the REV size within the non-Darcy flow is proposed tentatively. The concept of the REV in the non-Darcy flow is based on the definition of the REV. According to the determination of the REV in the Darcy flow, the intrinsic permeability k and non-Darcy coefficient β are used simultaneously for the determination of the REV in the non-Darcy flow. The pore pressure cohesive element (PPCE is developed with the subroutine in ABAQUS. Then the simulation method of the Darcy and non-Darcy flow in the fractured rock mass is built using the PPCE. The proposed plan is examined through the comparison with existing research results. It is validated that this technic is efficient and accurate in simulating the Darcy and non-Darcy flow in the fractured rock mass. Combined with fracture networks generated by Monte Carlo Simulation technique, the PPCE is applied to the study on the REV size. Both conditions of the Darcy and non-Darcy flow are simulated for comparison. The simulation results of this model show that the REV of the non-Darcy flow is inconsistent with the REV of the Darcy flow, and the REV of the non-Darcy flow is more significant than the REV of the Darcy flow. The intrinsic permeability k tensors obtained in the Darcy flow and the non-Darcy flow are basically the same.

The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

Directory of Open Access Journals (Sweden)

Keith I Pardee

2009-02-01

Full Text Available Heme is a ligand for the human nuclear receptors (NR REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO, and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD. A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.

The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

Science.gov (United States)

Pardee, Keith I; Xu, Xiaohui; Reinking, Jeff; Schuetz, Anja; Dong, Aiping; Liu, Suya; Zhang, Rongguang; Tiefenbach, Jens; Lajoie, Gilles; Plotnikov, Alexander N; Botchkarev, Alexey; Krause, Henry M; Edwards, Aled

2009-01-01

Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO), and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD). A 1.9 Å crystal structure of the REV-ERBβ LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBβ complex reveal that the Fe(II) form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II) LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions. PMID:19243223

Identification of Brucella melitensis Rev.1 vaccine-strain genetic markers: Towards understanding the molecular mechanism behind virulence attenuation.

Science.gov (United States)

Issa, Mohammad Nouh; Ashhab, Yaqoub

2016-09-22

Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard. The comparative analyses revealed 32 genetic alterations (30 SNPs, 1 single-bp insertion and 1 single-bp deletion) that are exclusively present in the Rev.1 genome. In silico analyses showed that 9 out of the 17 non-synonymous mutations are deleterious. Three ABC transporters are among the disrupted genes that can be linked to virulence attenuation. Out of the 32 mutations, 11 Rev.1 specific markers were selected to test their potential to discriminate Rev.1 using a bi-directional allele-specific PCR assay. Six markers were able to distinguish between Rev.1 and a set of control strains. We succeeded in identifying a panel of 32 genome-specific markers of the B. melitensis Rev.1 vaccine strain. Extensive in silico analysis showed that a considerable number of these mutations could severely affect the function of the associated genes. In addition, some of the discovered markers were able to discriminate Rev.1 strain from a group of control strains using practical PCR tests that can be applied in resource-limited settings. Copyright © 2016 Elsevier Ltd. All rights reserved.

Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

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Wesselingh Steven L

2007-07-01

Full Text Available Abstract Background The Sydney blood bank cohort (SBBC of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1. Although the cohort members have experienced differing clinical courses and now comprise slow progressors (SP as well as long-term nonprogressors (LTNP, longitudinal analysis of nef/long-terminal repeat (LTR sequences demonstrated convergent nef/LTR sequence evolution in SBBC SP and LTNP. Thus, the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef/LTR. Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36. Results The ability of Rev derived from D36 and C64 to bind the Rev responsive element (RRE in RNA binding assays was reduced by approximately 90% compared to Rev derived from HIV-1NL4-3, C18 or C98. D36 Rev also had a 50–60% reduction in ability to express Rev-dependent reporter constructs in mammalian cells. In contrast, C64 Rev had only marginally decreased Rev function despite attenuated RRE binding. In D36 and C64, attenuated RRE binding was associated with rare amino acid changes at 3 highly conserved residues; Gln to Pro at position 74 immediately N-terminal to the Rev activation domain, and Val to Leu and Ser to Pro at positions 104 and 106 at the Rev C-terminus, respectively. In D36, reduced Rev function was mapped to an unusual 13 amino acid extension at the Rev C-terminus. Conclusion These findings provide new genetic and mechanistic insights important for Rev function, and suggest that Rev function, not Rev/RRE binding may be rate limiting for HIV-1 replication. In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members.

Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev 3 mutant strains

International Nuclear Information System (INIS)

Lawrence, C.W.; Crhistensen, R.B.

1979-01-01

The role of rev3 gene function in uv-induced mutagenesis in the yeast Saccharomyces cerevisiae has been examined by determining the reversion of 12 well-defined cyc1 mutations in diploid strains homozygous for the rev3-1 or rev3-3 allale. The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations. We find that the rev3 mutations reduce the frequency of UV-induced reversion of all of the cyc1 alleles, though different classes of alleles respond to a different extent. These results imply that the rev3 gene function is required for the production of a wide variety of mutational events, though probably not all, and show that each of the three rev loci have different mutational phenotypes. Such diverse phenotypes are not predicted by the unitary model for bacterial mutagenes, suggesting that this is at best an incomplete description of eukaryotic mutagenesis

A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

Science.gov (United States)

Boons, Eline; Li, Guangdi; Vanstreels, Els; Vercruysse, Thomas; Pannecouque, Christophe; Vandamme, Anne-Mieke; Daelemans, Dirk

2014-12-01

The HIV Rev protein mediates the transport of partially and unspliced HIV mRNA from the nucleus to the cytoplasm. Rev multimerizes on a secondary stem-loop structure present in the viral intron-containing mRNA species and recruits the cellular karyopherin CRM1 to export viral mRNAs from the nucleus to the cytoplasm. Previously we have identified a single-domain intrabody (Nb(190)), derived from a llama heavy-chain antibody, which efficiently inhibits Rev multimerization and suppresses the production of infectious virus. We recently mapped the epitope of this nanobody and demonstrated that Rev residues K20 and Y23 are crucial for interaction while residues V16, H53 and L60 are important to a lesser extent. Here, we generated cell lines stably expressing Nb(190) and assessed the capacity of these cell lines to suppress the replication of different HIV-1 subtypes. These cells stably expressing the single-domain antibody are protected from virus-induced cytopathogenic effect even in the context of high multiplicity of infection. In addition, the replication of different subtypes of group M and one strain of group O is significantly suppressed in these cell lines. Next, we analysed the natural variations of Rev amino acids in sequence samples from HIV-1 infected patients worldwide and assessed the effect of Nb(190) on the most prevalent polymorphisms occurring at the key epitope positions (K20 and Y23) in Rev. We found that Nb(190) was able to suppress the function of these Rev variants except for the K20N mutant, which was present in only 0.7% of HIV-1 sequence populations (n = 4632). Cells stably expressing the single-domain intrabody Nb(190) are protected against virus-induced cytopathogenic effect and display a selective survival advantage upon infection. In addition, Nb(190) suppresses the replication of a wide range of different HIV-1 subtypes. Large-scale sequence analysis reveals that the Nb(190) epitope positions in Rev are well conserved across major HIV-1

Revised Safety Instruction 41 (IS41 REV.)

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SC Secretariat

2005-01-01

Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

Losers, Food, and Sex. Clerical Masculinity in the BBC Sitcom Rev.

Directory of Open Access Journals (Sweden)

Alexander Ornella

2016-11-01

Full Text Available Clerical masculinities, much like their lay/secular counterparts, often appear unchang¬ing because they are the products of naturalization processes. Clerical masculinities, however, are far from stable, for they live and breathe the dynamics of both their socio-religious context and their secular “others”. The BBC sitcom Rev. (BBC2, UK 2010–2014 is a refreshing take on the everyday life and problems of a vicar in the Church of England trying to avoid stereotypes that often come with clerical roles. Rev. (2010–2014 can be interpreted as an attempt to explore the negotiation processes of masculinity within an institution that is involved in the “production” of religion and gender roles. It shows that being a man in an institutional setting is as much a perfor¬mance as it is a more or less successful negotiation of other people’s expectations and one’s own worldview. In particular, the main male clerical characters in Rev. (2010– 2014 inhabit a position of power but all have their flaws. They can best be understood as losers whose clash with masculine systems renders them more human.

Meteorological explanation of wake clouds at Horns Rev wind farm

Energy Technology Data Exchange (ETDEWEB)

Emeis, S. [Karlsruhe Institute of Technology (Germany). Inst. for Meteorology and Climate Research

2010-08-15

The occurrence of wake clouds at Horns Rev wind farm is explained as mixing fog. Mixing fog forms when two nearly saturated air masses with different temperature are mixed. Due to the non-linearity of the dependence of the saturation water vapour pressure on temperature, the mixed air mass is over-saturated and condensation sets in. On the day in February 2008, when the wake clouds were observed at Horns Rev, cold and very humid air was advected from the nearby land over the warmer North Sea and led to the formation of a shallow layer with sea smoke or fog close above the sea surface. The turbines mixed a much deeper layer and thus provoked the formation of cloud trails in the wakes of the turbines. (orig.)

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

Science.gov (United States)

Vincendeau, Michelle; Kramer, Susanne; Hadian, Kamyar; Rothenaigner, Ina; Bell, Jeanne; Hauck, Stefanie M; Bickel, Christian; Nagel, Daniel; Kremmer, Elisabeth; Werner, Thomas; Leib-Mösch, Christine; Brack-Werner, Ruth

2010-10-23

In human astrocytes, restriction of HIV replication involves inhibition of HIV Rev activity. We previously identified a Rev-interacting human protein fragment (16.4.1) that can reduce Rev activity. The 16.4.1 sequence is contained in a group of highly similar host cell proteins, which we call the Risp family. Here we investigate whether the Risp family is connected to HIV replication in astrocytes. Cell/tissue lysates were analyzed for Risp expression by western blot with various anti-Risp antibodies. The interaction of astrocytic Risp members with Rev was investigated by affinity chromatography. Astrocytes were transfected with expression plasmids containing cDNAs encoding full-length Risp or the isolated 16.4.1 region for Risp overexpression or with siRNAs designed for Risp knock-down. Rev activity was investigated with a Rev-reporter assay. RNA levels were quantified by real-time RT-PCR, HIV Gag levels by p24ELISA. Expression of the Risp family was demonstrated in human brain tissues and astrocytes. Astrocytes were shown to produce Risp family members that interact with Rev. Production of HIV Gag proteins and Rev-dependent RNAs in persistently infected astrocytes increased upon Risp knock-down and decreased upon Risp overexpression. Risp knock-down increased Rev activity and raised proportions of Rev proteins in the nucleus of astrocytes. Our results link the Risp family to restriction of HIV production and inhibition of Rev activity in astrocytes. We conclude that the Risp family represents a novel family of host factors that can control HIV replication and may be important for the containment of HIV infection in brain reservoirs.

Innocuity and immune response to Brucella melitensis Rev.1 vaccine in camels (Camelus dromedarius

Directory of Open Access Journals (Sweden)

A. Benkirane

2014-10-01

Full Text Available A field trial was conducted in a camel brucellosis-free herd to evaluate antibody response to the Brucella melitensis Rev.1 vaccine in camels and assess shedding of the vaccine strain in milk. Twenty eight camels were divided into four groups according to their age and vaccination route. Groups A (n=3 and B (n=3 consisted of non-pregnant lactating female camels, vaccinated through subcutaneous and conjunctival routes, respectively. Groups C (n=10 consisted of 8-11 months old calves vaccinated through conjunctival route. The rest of the herd (n=12 composed of female and young camels were not vaccinated and were considered as the control group. Each animal from groups A, B and C was given the recommended dose of 2 x 109 colony forming units of Rev.1 vaccine irrespective of age or route of vaccination. Blood samples were collected from all the animals at the time of vaccination and at weekly, bi-weekly and monthly interval until 32 weeks post vaccination and from controls at weeks 8 and 24. The serological tests used were modified Rose Bengal Test, sero-agglutination test, and an indirect Enzyme Linked Immunosorbent Assay. Milk samples were collected from all vaccinated female camels and tested for the presence of Rev.1 vaccine strain. Most vaccinated animals started to show an antibody response at week 2 and remained positive until week 16. By week 20 post-vaccination all animals in the three groups were tested negative for Brucella antibodies. Bacteriological analysis of milk samples did not allow any isolation of Brucella melitensis. All samples were found Brucella negative in PCR analysis. The results of this study indicate that the Rev.1 vaccine induces seroconversion in camels. Rev.1 vaccine strain is not excreted in the milk of camels. These findings are promising as to the safe use of the Rev.1 vaccine in camels.

MicroRNA-340 inhibits the proliferation and promotes the apoptosis of colon cancer cells by modulating REV3L

Science.gov (United States)

Arivazhagan, Roshini; Lee, Jaesuk; Bayarsaikhan, Delger; Kwak, Peter; Son, Myeongjoo; Byun, Kyunghee; Salekdeh, Ghasem Hosseini; Lee, Bonghee

2018-01-01

DNA Directed Polymerase Zeta Catalytic Subunit (REV3L) has recently emerged as an important oncogene. Although the expressions of REV3L are similar in normal and cancer cells, several mutations in REV3L have been shown to play important roles in cancer. These mutations cause proteins misfolding and mislocalization, which in turn alters their interactions and biological functions. miRNAs play important regulatory roles during the progression and metastasis of several human cancers. This study was undertaken to determine how changes in the location and interactions of REV3L regulate colon cancer progression. REV3L protein mislocalization confirmed from the immunostaining results and the known interactions of REV3L was found to be broken as seen from the PLA assay results. The mislocalized REV3L might interact with new proteins partners in the cytoplasm which in turn may play role in regulating colon cancer progression. hsa-miR-340 (miR-340), a microRNA down-regulated in colon cancer, was used to bind to and downregulate REV3L, and found to control the proliferation and induce the apoptosis of colon cancer cells (HCT-116 and DLD-1) via the MAPK pathway. Furthermore, this down-regulation of REV3L also diminished colon cancer cell migration, and down-regulated MMP-2 and MMP-9. Combined treatment of colon cancer cells with miR-340 and 5-FU enhanced the inhibitory effects of 5-FU. In addition, in vivo experiments conducted on nude mice revealed tumor sizes were smaller in a HCT-116-miR-340 injected group than in a HCT-116-pCMV injected group. Our findings suggest mutations in REV3L causes protein mislocalization to the cytoplasm, breaking its interaction and is believed to form new protein interactions in cytoplasm contributing to colon cancer progression. Accordingly, microRNA-340 appears to be a good candidate for colon cancer therapy. PMID:29435169

Administrative Circular No. 26 (Rev.10) - Recognition of merit

CERN Multimedia

2014-01-01

Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

Energy Technology Data Exchange (ETDEWEB)

Morioka, Norimitsu, E-mail: mnori@hiroshima-u.ac.jp; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

2016-01-08

Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

International Nuclear Information System (INIS)

Morioka, Norimitsu; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

2016-01-01

Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

DEFF Research Database (Denmark)

Wernersson, Rasmus; Pedersen, Anders Gorm

2003-01-01

The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

DC Brushless Motor Control Design and Preliminary Testing for Independent 4-Wheel Drive Rev-11 Robotic Platform

Directory of Open Access Journals (Sweden)

Roni Permana Saputra

2012-03-01

Full Text Available This paper discusses the design of control system for brushless DC motor using microcontroller ATMega 16 that will be applied to an independent 4-wheel drive Mobile Robot LIPI version 2 (REV-11. The control system consists of two parts which are brushless DC motor control module and supervisory control module that coordinates the desired command to the motor control module. To control the REV-11 platform, supervisory control transmit the reference data of speed and direction of motor to control the speed and direction of each actuator on the platform REV-11. From the test results it is concluded that the designed control system work properly to coordinate and control the speed and direction of motion of the actuator motor REV-11 platform. 

Analysis of translesion DNA synthesis activity of the human REV1 protein, which is a key player in radiation-induced mutagenesis

International Nuclear Information System (INIS)

Masuda, Yuji; Kamiya, Kenji

2003-01-01

Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 gene are induction of mutations and prevention of cell death caused by ionizing radiation through the damage bypass DNA replication. The gene product possesses a deoxycytidyl transferase activity, which is required for translesion DNA synthesis of a variety of damaged bases and an abasic site. To elucidate molecular mechanisms of the mutagenesis and translesion DNA synthesis, it is important to characterize the enzymatic properties of the REV1 protein. Here, we describe a novel method for purifying the recombinant human REV1 protein and the anzymatic properties of the protein. We established an efficient system for induction of the recombinant human REV1 protein in Escherichia coli cells. The REV1 protein was purified to homogeneity using nickel-chelating sepharose, heparin sepharose and superdex 200 chromatography. When purified by this method, REV1 protein is free of endo-, exonuclease and DNA polymerase activities. The purified REV1 protein is suitable for enzymological studies, and we used this to biochemical characterization. The REV1 protein inserts dCMP opposite templates G, A, T, C and an abasic site and inserts dGMP and dTMP opposite template G. Kinetic analysis provided evidence for high efficiency for dCMP insertion opposite template G and an abasic site, suggesting that the REV1 protein play a role in translesion DNA synthesis of an abasic site. (author)

Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

Index Scriptorium Estoniae

Velthut-Sokka, Gea, 1977-

2004-01-01

Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

CERN Multimedia

Department Head Office - HR Department

2016-01-01

Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

CERN Multimedia

HR Department

2016-01-01

Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report 2003

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S.B.; Pedersen, John

2004-05-15

Elsam and Eltra built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm off the Danish west coast. The wind farm is sited 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine was erected in May 2002 and the last wind turbine tower of a total of 80 was in place by August 2002. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production by December 2002. The expected impact of the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind turbine towers and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horns Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site-specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrate was conducted in March 2003 and in September 2003. This report describes the first year results of surveys on hard substrate after the completion of the offshore wind farm at Horns Rev. (au)

REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.

Science.gov (United States)

Garaulet, Marta; Smith, Caren E; Gomez-Abellán, Purificación; Ordovás-Montañés, María; Lee, Yu-Chi; Parnell, Laurence D; Arnett, Donna K; Ordovás, José M

2014-04-01

Despite the solid connection between REV-ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations. Participants were 2214 subjects from Spanish Mediterranean (n = 1404) and North American (n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the "abdominally obese" group than in those of the "nonabdominally obese" group (p obesity than noncarriers, and the effect was of similar magnitude for both populations (OR ≈ 1.50). There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits (p obesity was also detected in the Mediterranean population. This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Determination of Geometrical REVs Based on Volumetric Fracture Intensity and Statistical Tests

Directory of Open Access Journals (Sweden)

Ying Liu

2018-05-01

Full Text Available This paper presents a method to estimate a representative element volume (REV of a fractured rock mass based on the volumetric fracture intensity P32 and statistical tests. A 150 m × 80 m × 50 m 3D fracture network model was generated based on field data collected at the Maji dam site by using the rectangular window sampling method. The volumetric fracture intensity P32 of each cube was calculated by varying the cube location in the generated 3D fracture network model and varying the cube side length from 1 to 20 m, and the distribution of the P32 values was described. The size effect and spatial effect of the fractured rock mass were studied; the P32 values from the same cube sizes and different locations were significantly different, and the fluctuation in P32 values clearly decreases as the cube side length increases. In this paper, a new method that comprehensively considers the anisotropy of rock masses, simplicity of calculation and differences between different methods was proposed to estimate the geometrical REV size. The geometrical REV size of the fractured rock mass was determined based on the volumetric fracture intensity P32 and two statistical test methods, namely, the likelihood ratio test and the Wald–Wolfowitz runs test. The results of the two statistical tests were substantially different; critical cube sizes of 13 m and 12 m were estimated by the Wald–Wolfowitz runs test and the likelihood ratio test, respectively. Because the different test methods emphasize different considerations and impact factors, considering a result that these two tests accept, the larger cube size, 13 m, was selected as the geometrical REV size of the fractured rock mass at the Maji dam site in China.

12MW Horns Rev experiment[Wind farm

Energy Technology Data Exchange (ETDEWEB)

Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

2007-10-15

The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

Rev 12 as a theology of history

Directory of Open Access Journals (Sweden)

Joanna Nowińska

2009-12-01

Full Text Available The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger, places (the temple, a desert, persons (the Child-Ruler, Michael with the Old Testament figurative exposing, a typical one for such a book (the Woman with Child, the heaven, the dragon, enriched with a lot of symbols (a crown, a horn, the moon under feet. God’s interference into World history is presented through lightning, voices, thunder, an earthquake and great hail, that stress His power and supremacy. The biblical writer refers to events, which make place whole the time in the natural- and supernatural space, like: the war between God and evil, persecutions, hiding, God’s care of men.  The specific literary structure of Rev 12, contrary to the other parts of that book, seem to help to put an accent for the fundamental truths for transcendental theology of history of which the most important is the eternal rule of God and only accidental, finished in the time perspective of Satan’s position.

The effects of cynodon dactylon on the immune response of NMRI-MICE after challenge with REV1

Directory of Open Access Journals (Sweden)

Behrooz Ilkhanizadeh

2016-10-01

Full Text Available Cynodon dactylon is used in Iranian traditional medicine as a healing agent for reducing the complications of diabetes mellitus. We proposed that Cynodon dactylon may perform its effects through moderating humoral and cellular immune responses. We aimed to determine the possible effects of hydroalcholic extract of Cynodon dactylonon humoral and cellular immune responses following the Rev1 challenge in the mouse model. 20 NMRI male mice were randomly grouped in two equal groups and immunized with Rev1[0.1 ml Rev1+0.9 PBS[. Mice in the treatment group orally received 400 mg/kg hydroalcoholic extract of Cynodon dactylon every day from the beginning of the study for 2 weeks. Blood samples were obtained from the animals 5 days after the last injection. Moreover, 48 hr before bleeding time, Rev1[0.1 ml Rev1+0.9 PBS[was injected into the left hind foot pad of mice. The levels of anti-Rev1 antibody and the specific cellular immune responses were measured by microhemagglutination test and footpad thickness, respectively. Moreover, susceptibility of macrophages respiratory burst and proliferation of immune cells were measured in order withNitroblue tetrazolium[NBT] and Microculture Tetrazolium Assay [MTT]. The concentrations of IL-1, TNFα, Il-6, and IL-10 in the serum were determined using commercially available ELISA kits. We found a significant increase in anti-Rev1 antibody levels and simultaneously a significant decrease in the level of cellular immunity[DTH] in the treatment group compared to the control group. Lymphocyte proliferation index in splenocytes was significantly increased in the treatment group. However, the level of respiratory burst in phagocytic population of splenocytes dramatically decreased in the treatment group compared to the control. A significant decrease in IL-6, TNF-α , IL-1 and increaseIl-10 serum levels were also seen in the treatment group. Cynodon dactylon extract could have an anti-inflammatory effect through

Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.

Science.gov (United States)

Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi

2010-03-15

Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Additionally, structure-activity relationship analysis by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. Copyright 2010 Elsevier Ltd. All rights reserved.

Rev 12 as a theology of history

OpenAIRE

Joanna Nowińska

2009-01-01

The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger), places (the temple, a desert), persons (the Child-Ruler, Michael) with the Old T...

ENDF/B-5 Fission Products Library. Rev. 2

International Nuclear Information System (INIS)

Schwerer, O.; Pronyaev, V.G.; Lemmel, H.D.

1984-07-01

This document summarizes contents and documentation of the 1984 version of the Fission Products Nuclear Data File of the ENDF/B-5 Library (Rev. 2) maintained by the National Nuclear Data Center (NNDC) at the Brookhaven National Laboratory, USA. This file contains numerical neutron reaction data and decay data for 877 fission product nuclides. The entire file or selective retrievals from it can be obtained on magnetic tape from the IAEA Nuclear Data Section. (author)

Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1.

Science.gov (United States)

Noutsios, Georgios T; Papi, Rigini M; Ekateriniadou, Loukia V; Minas, Anastasios; Kyriakidis, Dimitrios A

2012-03-01

In the present study forty-four Greek endemic strains of Br. melitensis and three reference strains were genotyped by Multi locus Variable Number Tandem Repeat (ML-VNTR) analysis based on an eight-base pair tandem repeat sequence that was revealed in eight loci of Br. melitensis genome. The forty-four strains were discriminated from the vaccine strain Rev-1 by Restriction Fragment Length Polymorphism (RFLP) and Denaturant Gradient Gel Electrophoresis (DGGE). The ML-VNTR analysis revealed that endemic, reference and vaccine strains are genetically closely related, while most of the loci tested (1, 2, 4, 5 and 7) are highly polymorphic with Hunter-Gaston Genetic Diversity Index (HGDI) values in the range of 0.939 to 0.775. Analysis of ML-VNTRs loci stability through in vitro passages proved that loci 1 and 5 are non stable. Therefore, vaccine strain can be discriminated from endemic strains by allele's clusters of loci 2, 4, 6 and 7. RFLP and DGGE were also employed to analyse omp2 gene and reveled different patterns among Rev-1 and endemic strains. In RFLP, Rev-1 revealed three fragments (282, 238 and 44 bp), while endemic strains two fragments (238 and 44 bp). As for DGGE, the electrophoretic mobility of Rev-1 is different from the endemic strains due to heterologous binding of DNA chains of omp2a and omp2b gene. Overall, our data show clearly that it is feasible to genotype endemic strains of Br. melitensis and differentiate them from vaccine strain Rev-1 with ML-VNTR, RFLP and DGGE techniques. These tools can be used for conventional investigations in brucellosis outbreaks.

Administrative circular n°23 (Rev. 3) – Special working hours

CERN Multimedia

2013-01-01

Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

Wind Farm Wake: The 2016 Horns Rev Photo Case

Directory of Open Access Journals (Sweden)

Charlotte Bay Hasager

2017-03-01

Full Text Available Offshore wind farm wakes were observed and photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC. These new images show highly contrasting conditions regarding the wind speed, turbulence intensity, atmospheric stability, weather conditions and wind farm wake development as compared to the Horns Rev 1 photographs from 12 February 2008. The paper examines the atmospheric conditions from satellite images, radiosondes, lidar and wind turbine data and compares the observations to results from atmospheric meso-scale modelling and large eddy simulation. Key findings are that a humid and warm air mass was advected from the southwest over cold sea and the dew-point temperature was such that cold-water advection fog formed in a shallow layer. The flow was stably stratified and the freestream wind speed was 13 m/s at hub height, which means that most turbines produced at or near rated power. The wind direction was southwesterly and long, narrow wakes persisted several rotor diameters downwind of the wind turbines. Eventually mixing of warm air from aloft dispersed the fog in the far wake region of the wind farm.

Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev ...

Indian Academy of Sciences (India)

First page Back Continue Last page Overview Graphics. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev. Mod. Phys. 70, 1039 (1998) ). Differences due to changes in cation radius causing bending of Mn-O-Mn bonds. Extreme sensitivity to small changes.

Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

DEFF Research Database (Denmark)

Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai

We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors

International Nuclear Information System (INIS)

Kiss, A.; Li, L.; Gettemeier, T.; Venkatesh, L.K.

2003-01-01

Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear cofactors. In yeast two-hybrid screens of a human lymph node derived cDNA expression library, we identified the human nucleoporin Nup98 as a highly specific and potent interactor of the Rev NES. Using an extensive panel of nuclear export positive and negative mutants of the functionally homologous NESs of the HIV-1 Rev, human T cell leukemia virus type 1 (HTLV-1) Rex, and equine infectious anemia virus (EIAV) Rev proteins, physiologically significant interaction of hNup98 with the various NESs was demonstrated. Missense mutations in the yeast nuclear export factor Crm1p that abrogated Rev NES interaction with the XXFG repeat-containing nucleoporin, Rab/hRIP, had minimal effects on the interaction of GLFG repeat-containing hNup98. Functional analysis of Nup98 domains required for nuclear localization demonstrated that the entire ORF was required for efficient incorporation into the nuclear envelope. A putative nuclear localization signal was identified downstream of the GLFG repeat region. Whereas overexpression of both full-length Nup98 and the amino-terminal GLFG repeat region, but not the unique carboxy-terminal region, induced significant suppression of HIV unspliced RNA export, lower levels of exogenous Nup98 expression resulted in a relatively modest increase in unspliced RNA export. These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection

Wind Farm Wake: The Horns Rev Photo Case

DEFF Research Database (Denmark)

Hasager, Charlotte Bay; Rasmussen, Leif; Peña, Alfredo

2013-01-01

The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surf...... in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog....

The calculational VVER burnup Credit Benchmark No.3 results with the ENDF/B-VI rev.5 (1999)

Energy Technology Data Exchange (ETDEWEB)

Rodriguez Gual, Maritza [Centro de Tecnologia Nuclear, La Habana (Cuba). E-mail: mrgual@ctn.isctn.edu.cu

2000-07-01

The purpose of this papers to present the results of CB3 phase of the VVER calculational benchmark with the recent evaluated nuclear data library ENDF/B-VI Rev.5 (1999). This results are compared with the obtained from the other participants in the calculations (Czech Republic, Finland, Hungary, Slovaquia, Spain and the United Kingdom). The phase (CB3) of the VVER calculation benchmark is similar to the Phase II-A of the OECD/NEA/INSC BUC Working Group benchmark for PWR. The cases without burnup profile (BP) were performed with the WIMS/D-4 code. The rest of the cases have been carried with DOTIII discrete ordinates code. The neutron library used was the ENDF/B-VI rev. 5 (1999). The WIMS/D-4 (69 groups) is used to collapse cross sections from the ENDF/B-VI Rev. 5 (1999) to 36 groups working library for 2-D calculations. This work also comprises the results of CB1 (obtained with ENDF/B-VI rev. 5 (1999), too) and CB3 for cases with Burnup of 30 MWd/TU and cooling time of 1 and 5 years and for case with Burnup of 40 MWd/TU and cooling time of 1 year. (author)

Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

CERN Multimedia

Department Head Office - HR Department

2016-01-01

Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

CERN Multimedia

2014-01-01

Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S.B.; Pedersen, John

2005-05-15

Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S B; Pedersen, John

2005-05-15

Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

LLNL Radiation Protection Program (RPP) Rev 9.2, Implementation of 10 CFR 835, 'Occupational Radiation Protection'

Energy Technology Data Exchange (ETDEWEB)

Shingleton, K. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2011-06-15

The Department of Energy (DOE) originally issued Part 10 CFR 835, Occupational Radiation Protection, on January 1, 1994. This regulation, hereafter referred to as “the Rule”, required DOE contractors to develop and maintain a DOE-approved Radiation Protection Program (RPP); DOE approved the initial Lawrence Livermore National Laboratory (LLNL) RPP (Rev 2) on 6/29/95. DOE issued a revision to the Rule on December 4, 1998 and approved LLNL’s revised RPP (Rev 7.1) on 11/18/99. DOE issued a second Rule revision on June 8, 2007 (effective July 9, 2007) and on June 13, 2008 approved LLNL’s RPP (Rev 9.0) which contained plans and measures for coming into compliance with the 2007 Rule changes. DOE issued a correction to the Rule on April 21, 2009.

Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

CERN Multimedia

2014-01-01

Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

CERN Multimedia

Department Head Office - HR Department

2016-01-01

Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

Evaluación externa en la LOMCE. Reválidas, exclusión y competitividad

Directory of Open Access Journals (Sweden)

Ángel I. Pérez Gómez

2014-01-01

Full Text Available La evaluación de las competencias o cualidades humanas que cada aprendiz ha de desarrollar de manera singular para afrontar la complejidad de la era digital contemporánea es incompatible con las reválidas, test y pruebas externas estandarizadas, iguales para todos. Las cualidades más importantes del aprendizaje en la era digital —autodirección, iniciativa, creatividad, pensamiento crítico, solución de problemas y autoevaluación— son difícilmente evaluables mediante instrumentos baratos y masivos «de papel y lápiz», como los test estandarizados o las reválidas externas; requieren, por el contrario, herramientas y procesos más complejos, plurales y flexibles como la observación continua de los equipos docentes sobre el quehacer y los procesos y productos de los aprendices (Soto Gómez, 2014. La LOMCE,1 fiel exponente de la pedagogía conservadora del movimiento GERM,2 recupera las reválidas, pues apuesta por la estandarización de aprendizajes superficiales en lugar de potenciar el desarrollo singular de cada aprendiz hasta el máximo de sus posibilidades.

hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

Energy Technology Data Exchange (ETDEWEB)

Li Ziqiang; Zhang Hong; McManus, Terrence P.; McCormick, J. Justin; Lawrence, Christopher W.; Maher, Veronica M

2002-12-29

In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-blocking lesions, and for the majority of spontaneous mutations. To determine whether hREV3, the human homolog of yeast REV3, is similarly involved in error-prone translesion synthesis past UV photoproducts and other lesions that block DNA replication, an hREV3 antisense construct under the control of the TetP promoter was transfected into an infinite life span human fibroblast cell strain that expresses a high level of tTAk, the activator of that promoter. Three transfectant strains expressing high levels of hREV3 antisense RNA were identified and compared with their parental cell strain for sensitivity to the cytotoxic and mutagenic effects of UV. The three hREV3 antisense-expressing cell strains were not more sensitive than the parental strain to the cytotoxic effect of UV, but the frequency of mutants induced by UV in their HPRT gene was significantly reduced, i.e. to 14% that of the parent. Two of these hREV3 antisense-expressing cell strains were compared with the parental strain for sensitivity to ({+-})-7{beta},8{alpha}-dihydroxy-9{alpha},10{alpha}-epoxy-7,8,9,10-tetrahydro= benzo[a]pyrene (BPDE). They were not more sensitive than the parent strain to the cytotoxic effect of BPDE, but the frequency of mutants induced was significantly reduced, i.e. in one strain, to 17% that of the parent, and in the other, to 24%. DNA sequencing showed that the kinds of mutations induced by BPDE in the parental and the derivative strains did not differ and were similar to those found previously with finite life span human fibroblasts. The data strongly support the hypothesis that hRev3 plays a critical role in the induction of mutations by UV or BPDE. Because the level of hRev3 protein in human fibroblasts is below the level of antibody

hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

International Nuclear Information System (INIS)

Li Ziqiang; Zhang Hong; McManus, Terrence P.; McCormick, J. Justin; Lawrence, Christopher W.; Maher, Veronica M.

2002-01-01

In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-blocking lesions, and for the majority of spontaneous mutations. To determine whether hREV3, the human homolog of yeast REV3, is similarly involved in error-prone translesion synthesis past UV photoproducts and other lesions that block DNA replication, an hREV3 antisense construct under the control of the TetP promoter was transfected into an infinite life span human fibroblast cell strain that expresses a high level of tTAk, the activator of that promoter. Three transfectant strains expressing high levels of hREV3 antisense RNA were identified and compared with their parental cell strain for sensitivity to the cytotoxic and mutagenic effects of UV. The three hREV3 antisense-expressing cell strains were not more sensitive than the parental strain to the cytotoxic effect of UV, but the frequency of mutants induced by UV in their HPRT gene was significantly reduced, i.e. to 14% that of the parent. Two of these hREV3 antisense-expressing cell strains were compared with the parental strain for sensitivity to (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). They were not more sensitive than the parent strain to the cytotoxic effect of BPDE, but the frequency of mutants induced was significantly reduced, i.e. in one strain, to 17% that of the parent, and in the other, to 24%. DNA sequencing showed that the kinds of mutations induced by BPDE in the parental and the derivative strains did not differ and were similar to those found previously with finite life span human fibroblasts. The data strongly support the hypothesis that hRev3 plays a critical role in the induction of mutations by UV or BPDE. Because the level of hRev3 protein in human fibroblasts is below the level of antibody detection, it was not

Metabolism and apoptotic properties of elevated ceramide in HT29(rev) cells

NARCIS (Netherlands)

Veldman, R J; Klappe, K; Hoekstra, D; Kok, J W

1998-01-01

Ceramide (Cer) has been implicated in the regulation of apoptosis. In this study, we elevated cellular Cer levels in human colon-carcinoma (HT29(rev)) cells by incubating the cells in the presence of bacterial sphingomyelinase (bSMase) or, alternatively, in the presence of C2-Cer, a short-chain

Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

Energy Technology Data Exchange (ETDEWEB)

Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

2005-07-01

The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

International Nuclear Information System (INIS)

Kjaer Christensen, T.; Hounisen, J.P.

2005-01-01

The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

Energy Technology Data Exchange (ETDEWEB)

Kuehn, Susanne

2005-07-01

Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

Directory of Open Access Journals (Sweden)

Dudley Jaquelin P

2009-02-01

Full Text Available Abstract Background Mouse mammary tumor virus (MMTV encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells. We have shown that Rem is expressed from a doubly spliced RNA, typical of complex retroviruses. Several recent reports indicate that MMTV can infect human cells, suggesting that MMTV might interact with human retroviruses, such as human immunodeficiency virus (HIV, human T-cell leukemia virus (HTLV, and human endogenous retrovirus type K (HERV-K. In this report, we test whether the export/regulatory proteins of human complex retroviruses will increase expression from vectors containing the Rem-responsive element (RmRE. Results MMTV Rem, HIV Rev, and HTLV Rex proteins, but not HERV-K Rec, enhanced expression from an MMTV-based reporter plasmid in human T cells, and this activity was dependent on the RmRE. No RmRE-dependent reporter gene expression was detectable using Rev, Rex, or Rec in HC11 mouse mammary cells. Cell fractionation and RNA quantitation experiments suggested that the regulatory proteins did not affect RNA stability or nuclear export in the MMTV reporter system. Rem had no demonstrable activity on export elements from HIV, HTLV, or HERV-K. Similar to the Rem-specific activity in rodent cells, the RmRE-dependent functions of Rem, Rev, or Rex in human cells were inhibited by a dominant-negative truncated nucleoporin that acts in the Crm1 pathway of RNA and protein export. Conclusion These data argue that many retroviral regulatory proteins recognize similar complex RNA structures, which may depend on the presence of cell-type specific proteins. Retroviral protein activity on the RmRE appears to affect a post-export function of the reporter RNA. Our results provide additional evidence that MMTV is a complex retrovirus with the potential for viral interactions in human cells.

RevSex duplication-induced and sex-related differences in the SOX9 regulatory region chromatin landscape in human fibroblasts.

Science.gov (United States)

Lybæk, Helle; de Bruijn, Diederik; den Engelsman-van Dijk, Anke H A; Vanichkina, Darya; Nepal, Chirag; Brendehaug, Atle; Houge, Gunnar

2014-03-01

It was recently shown that duplications of the RevSex element, located 0.5 Mb upstream of SOX9, cause XX-disorder of sex development (DSD), and that deletions cause XY-DSD. To explore how a 148 kb RevSex duplication could have turned on gonadal SOX9 expression in the absence of SRY in an XX-male, we examined the chromatin landscape in primary skin fibroblast cultures from the index, his RevSex duplication-carrier father and six controls. The ENCODE project supports the notion that chromatin state maps show overlap between different cell types, i.e., that our study of fibroblasts could be of biological relevance. We examined the SOX9 regulatory region by high-resolution ChIP-on-chip experiments (a kind of "chromatin-CGH") and DNA methylation investigations. The RevSex duplication was associated with chromatin changes predicting better accessibility of the SRY-responsive TESCO enhancer region 14-15 kb upstream of SOX9. Four kb downstream of the TESCO evolutionary conserved region, a peak of the enhancer/promoter-associated H3K4me3 mark was found together with a major dip of the repressive H3K9me3 chromatin mark. Similar differences were also found when three control males were compared with three control females. A marked male/female difference was a more open chromatin signature in males starting ~400 kb upstream of SOX9 and increasing toward the SOX9 promoter. In the RevSex duplication-carrier father, two positions of DNA hypomethylation were also found, one corresponding to the H3K4me3 peak mentioned above. Our results suggest that the RevSex duplication could operate by inducing long-range epigenetic changes. Furthermore, the differences in chromatin state maps between males and females suggest that the Y chromosome or X chromosome dosage may affect chromatin conformation, i.e., that sex-dependent gene regulation may take place by chromatin modification.

Benchmark test of JENDL-3T and -3T/Rev.1

International Nuclear Information System (INIS)

Takano, Hideki; Kaneko, Kunio.

1989-10-01

The fast reactor 70-group constant set JFS-3-J3T has been generated by using the JENDL-3T nuclear data. One-dimensional 21-benchmark cores and the ZPPR-9 core were analysed with the JFS-3-J3T set. The results obtained are summarized as follows: (1) The values of keff are underestimated by 0.6% for Pu-fueled cores and overestimated by 2% for U-fueled cores. (2) The central reaction rate ratio 239 σ f φ/ 235 σ f φ is in a good agreement with the experimental value, though 238 σ c φ/ 239 σ f φ and 238 σ f φ/ 235 σ f φ are overestimated. (3) Doppler and Na-void reactivities are in a good agreement with the measured data. (4) The prediction accuracy of radial reaction rate distributions are improved in the comparison of the results obtained with the JENDL-2 data. Furthermore, the benchmark test of JENDL-3T/Rev. 1 which was revised from JENDL-3T for several important nuclides has been again performed. It was shown that JENDL-3T/Rev. 1 would predict nuclear characteristics more satisfactorily than JENDL-3T. (author)

SSC-K code users manual (rev.1)

International Nuclear Information System (INIS)

Kwon, Y. M.; Lee, Y. B.; Chang, W. P.; Hahn, D.

2002-01-01

The Supper System Code of KAERI (SSC-K) is a best-estimate system code for analyzing a variety of off-normal or accidents in the heat transport system of a pool type LMR design. It is being developed at Korea Atomic Energy Research Institution (KAERI) on the basis of SSC-L, originally developed at BNL to analyze loop-type LMR transients. SSC-K can handle both designs of loop and pool type LMRs. SSC-K contains detailed mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, coolant, fuel elements, and structures to accident conditions. This report provides a revised User's Manual (rev.1) of the SSC-K computer code, focusing on phenomenological model descriptions for new thermal, hydraulic, neutronic, and mechanical modules. A comprehensive description of the models for pool-type reactor is given in Chapters 2 and 3; the steady-state plant characterization, prior to the initiation of transient is described in Chapter 2 and their transient counterparts are discussed in Chapter 3. Discussions on the intermediate heat exchanger (IHX) and the electromagnetic (EM) pump are described in Chapter 4 and 5, respectively. A model of passive safety decay heat removal system (PSDRS) is discussed in Chapter 6, and models for various reactivity feedback effects are discussed in Chapter 7. In Chapter 8, constitutive laws and correlations required to execute the SSC-K are described. New models developed for SSC-K rev.1 are two dimensional hot pool model in Chapter 9, and long term cooling model in Chapter 10. Finally, a brief description of MINET code adopted to simulate BOP is presented in Chapter 11. Based on test runs for typical LMFBR accident analyses, it was found that the present version of SSC-K would be used for the safety analysis of KALIMER. However, the further validation of SSC-K is required for real applications. It is noted that the user's manual of SSC-K will be revised later with the

Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

CERN Multimedia

2015-01-01

Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

CERN Multimedia

2013-01-01

Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

Administrative Circular No. 14 (Rev. 2)

CERN Document Server

HR Department

2007-01-01

The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.

Directory of Open Access Journals (Sweden)

Corinne Jud

Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.

48 CFR 53.301-18 - SF 18 (Rev. 6/95), Request for Quotations.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 18 (Rev. 6/95), Request for Quotations. 53.301-18 Section 53.301-18 Federal Acquisition Regulations System FEDERAL ACQUISITION... for Quotations. EC01MY91.002 [60 FR 34763, July 3, 1995] ...

Specificity of RSG-1.2 peptide binding to RRE-IIB RNA element of HIV-1 over Rev peptide is mainly enthalpic in origin.

Science.gov (United States)

Kumar, Santosh; Bose, Debojit; Suryawanshi, Hemant; Sabharwal, Harshana; Mapa, Koyeli; Maiti, Souvik

2011-01-01

Rev is an essential HIV-1 regulatory protein which binds to the Rev responsive element (RRE) present within the env gene of HIV-1 RNA genome. This binding facilitates the transport of the RNA to the cytoplasm, which in turn triggers the switch between viral latency and active viral replication. Essential components of this complex have been localized to a minimal arginine rich Rev peptide and stem IIB region of RRE. A synthetic peptide known as RSG-1.2 binds with high binding affinity and specificity to the RRE-IIB than the Rev peptide, however the thermodynamic basis of this specificity has not yet been addressed. The present study aims to probe the thermodynamic origin of this specificity of RSG-1.2 over Rev Peptide for RRE-IIB. The temperature dependent melting studies show that RSG-1.2 binding stabilizes the RRE structure significantly (ΔT(m) = 4.3°C), in contrast to Rev binding. Interestingly the thermodynamic signatures of the binding have also been found to be different for both the peptides. At pH 7.5, RSG-1.2 binds RRE-IIB with a K(a) = 16.2±0.6×10(7) M(-1) where enthalpic change ΔH = -13.9±0.1 kcal/mol is the main driving force with limited unfavorable contribution from entropic change TΔS = -2.8±0.1 kcal/mol. A large part of ΔH may be due to specific stacking between U72 and Arg15. In contrast binding of Rev (K(a) = 3.1±0.4×10(7) M(-1)) is driven mainly by entropy (ΔH = 0 kcal/mol and TΔS = 10.2±0.2 kcal/mol) which arises from major conformational changes in the RNA upon binding.

Guidance and considerations for implementation of INFCIRC/225/Rev.3, the physical protection of nuclear material

International Nuclear Information System (INIS)

1997-09-01

The Physical Protection of Nuclear Material, INFCIRC/225/Rev.3, provides recommendations for the physical protection of nuclear material against theft in use, storage and transport, whether national or international and whether peaceful or military, and contains provisions relating to the sabotage of nuclear material or facilities. The recommendations contained in INFCIRC/225/Rev.3 detail the elements that should be included in a State's system of physical protection. It also recognizes the adverse health and safety consequences arising from the theft of nuclear material and the sabotage of nuclear material or facilities. Most industrial and developing countries use these recommendations to some extent in the establishment and operation of their physical protection systems. Although INFCIRC/225/Rev.3 provides recommendations for protecting materials and facilities from theft or sabotage, it does not provide in-depth details for these recommendations. In June 1996, the IAEA convened a consultants meeting to consider this matter. This report is the result of continuing discussions and drafts over a period of nine months. The intent of this guidance is to provide a broader basis for relevant State organizations to prescribe appropriate requirements for the use of nuclear materials which are compatible with accepted international practice

Technical reports retrieval system(rev. 1) in the field of nuclear energy

International Nuclear Information System (INIS)

Choi, S.D.; Lee, Y.K.; Yim, S.H.

1983-01-01

TRRS(rev. 1), on-line Technical Reports Retrieval System, a set of computer programs, was designed and developed to provide fast and efficient access to computer-based information files. This system was foucused upon its application to the retrival of technical reports collected in KAERI, and developed not only to meet the requirements of researchers sitting at terminal but to accomodate its sufficiently general logic to other computer systems. The retrival program language is FORTRAN IV Plus. The users can search the whole files using next eleven TRRS(rev. 1) commands, HELP, SEARCH, LOOK, COMBINE, EXPAND, SELECT, REVIEW, RESTART, TYPE, PRINT, and END. The special features of this system are as follows. First, the SEARCH command can process full and truncation (truncation mark is %), and can combine such truncated terms using Boolean operators, and (*), and and-not (.). Second, COMBINE command can combine set numbers with year(s), language(s) and a substring of titles. Third, after EXPAND command, either full or truncated term, SELECT command brings same result of SEARCH command. Finally, real time response is very short, real time response is very short, usually within a second or less. (Author)

The role of hRev7, the accessory subunit of hPolζ, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE

Directory of Open Access Journals (Sweden)

Maher Veronica M

2010-12-01

Full Text Available Abstract Background DNA polymerase zeta (Polζ is a specialized DNA polymerase that, unlike classical replicative polymerases, is capable of replicating past DNA lesions, i.e. of performing translesion synthesis (TLS. The catalytic subunit of hPolζ, hRev3, has been shown to play a critical role in DNA damage-induced mutagenesis in human cells, but less is known about the role of hRev7, the accessory subunit of hPolζ, in such mutagenesis. To address this question, we recently generated human fibroblasts with very significantly reduced levels of hRev7 protein and demonstrated that hRev7 is required to protect cells from ultraviolet(254 nm (UV radiation-induced cytotoxicity and mutagenesis (McNally et al., DNA Repair 7 (2008 597-604. The goal of the present study was to determine whether hRev7 is similarly involved in the tolerance of DNA damage induced by benzo[a]pyrene diol epoxide (BPDE, the reactive form of the widespread environmental carcinogen benzo[a]pyrene. Methods To determine whether hRev7 also plays a role in protecting human cells from the cytotoxicity and mutagenesis induced by benzo[a]pyrene diol epoxide (BPDE, cell strains with reduced hRev7 were compared to their parental strain and a vector control strain for the effect of BPDE on cell survival, induction of mutations, and the ability to progress through the cell cycle. Results The results show that cell strains with reduced hRev7 are more sensitive to the cytotoxic effect of BPDE than the control strains, and progress through S-phase at a slower rate than the control cells following BPDE treatment, indicating that hRev7, and likely hPolζ, is required for efficient bypass of BPDE-induced DNA lesions. However, neither the frequency nor kinds of mutations induced by BPDE in cells with reduced hRev7 differ significantly from those induced in the control strains, suggesting that hPolζ is not essential for inserting nucleotides opposite BPDE-induced DNA damage. Conclusions Taken

Investigations of migratory birds during operation of Horns Rev offshore wind farm: Preliminary note of analysis of data from spring 2004

International Nuclear Information System (INIS)

Kjaer Christensen, T.; Hounisen, J.P.

2004-01-01

In February 1998, the Ministry of the Environment gave Elsam A/S and Eltra A.m.b.a. approval to erect a wind farm, capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk off the west coast of Jutland. Construction activities at Horns Rev started in September 2001 and were finished in summer 2002. The entire project has been organised as a demonstration project to assess the technical, economic and environmental constraints on the future development of electric power production in Danish offshore environments. Within the framework of the environmental programme, bird investigations have been carried out in relation to the risk of collision between birds and wind turbines since 2002. To provide the latest update on the results from the bird investigations, this note presents results compiled during spring 2004 and deals with a preliminary analysis of effects on birds present at Horns Rev during commercial operation of the Horns Rev wind farm. Due to the remoteness of the area it has not been possible to obtain base-line investigation of bird occurrence and behaviour at the wind farm site. (au)

Administrative circular No. 20 (Rev. 2) – Use of private vehicules for journeys on official duty

CERN Multimedia

HR Department

2011-01-01

Administrative Circular No. 20 (Rev. 2) entitled "Use of private vehicles for journeys on official duty", adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 January 2011, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 20 (Rev. 1) entitled "Use of private vehicles on official duty" of April 1993. This new version introduces, in particular, the payment of a kilometer allowance in case of emergency during standby duty or when on call and a simplified calculation of the allowance for journeys between sites. This circular also clarifies the type of permitted private vehicles. Department Head Office  

Administrative circular No. 2 (Rev. 5) – Recruitment, appointment and possible developments regarding the contractual position of staff members

CERN Document Server

HR Department

2011-01-01

Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 1 September 2011, is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 2 (Rev. 4) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2009. Department Head Office

Administrative circular n°11 (REV. 2) – Categories of members of the personnel

CERN Multimedia

2012-01-01

Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

Base-line investigations of birds in relation to an offshore wind farm at Horns Rev: results and conclusions 2000/2001

Energy Technology Data Exchange (ETDEWEB)

Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [NERI, Dept. of Coastal Zone Ecology, Roskilde (Denmark)

2001-07-01

This report presents the combined results of two years of base-line investigations of birds performed during August 1999 - April 2001 in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. Based on the distribution of the most abundant bird species recorded during 13 aerial surveys, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, occurring in the areas north and south of Horns Rev, and with low numbers occurring on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although the common scoter was found in relatively high numbers on the southeast slopes of Horns Rev and within the wind farm area in the April 2001 survey. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affects less than 1% of the different species, except divers of which 1.65% will be affected. If the birds avoid the wind farm area and an adjacent 4 km zone (worst case scenario), it is estimated to affect 11% of the common scoter, 10% of the gannet, 7-9% of the divers, alcids and velvet scoter and 0-6% of the remaining species. The seasonal occurrence of the recorded species was fully comparable to the seasonal occurrence of these species recorded at Blaevandshuk since 1963. Year-to-year variation in abundance between the seasons August 1999 - April 2000 and August 2000 - April 2001 was mainly found in species that migrate through the Horns Rev area (terns, gannet, kittiwake), and with less pronounced variation in

Base-line investigations of birds in relation to an offshore wind farm at Horns Rev: results and conclusions 2000/2001

International Nuclear Information System (INIS)

Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

2001-01-01

This report presents the combined results of two years of base-line investigations of birds performed during August 1999 - April 2001 in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. Based on the distribution of the most abundant bird species recorded during 13 aerial surveys, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, occurring in the areas north and south of Horns Rev, and with low numbers occurring on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although the common scoter was found in relatively high numbers on the southeast slopes of Horns Rev and within the wind farm area in the April 2001 survey. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affects less than 1% of the different species, except divers of which 1.65% will be affected. If the birds avoid the wind farm area and an adjacent 4 km zone (worst case scenario), it is estimated to affect 11% of the common scoter, 10% of the gannet, 7-9% of the divers, alcids and velvet scoter and 0-6% of the remaining species. The seasonal occurrence of the recorded species was fully comparable to the seasonal occurrence of these species recorded at Blaevandshuk since 1963. Year-to-year variation in abundance between the seasons August 1999 - April 2000 and August 2000 - April 2001 was mainly found in species that migrate through the Horns Rev area (terns, gannet, kittiwake), and with less pronounced variation in

An analysis of international situation concerning nuclear security. Focused on the revision to INFCIRC/225/Rev.5

International Nuclear Information System (INIS)

Inamura, Tomoaki; Tanabe, Tomoyuki

2011-01-01

Since the September 11 attacks in 2001, counterterrorism measures have become not just domestic issues but critical issues that need international cooperation. Various nuclear security measures are in place as part of international counterterrorism measures. This report looks at the trend of international nuclear security measures to get implications for Japan, focusing on INFCIRC/225/Rev.5, an international guideline for physical protection of nuclear materials and nuclear facilities drawn up by IAEA. The observations of this report are as follows: 1) While legally binding nuclear security measures such as multilateral treaties and United Nations Security Council Resolutions impose minimum requirements on individual countries, the approaches led by IAEA or individual countries or private associations aim at more detailed consideration or information sharing to further improve nuclear security. 2) INFCIRC/225/Rev.5 comprises new concepts such as risk-based physical protection and nuclear security culture, as well as extended range of threats such as insiders or stand-off attacks and broader scope of measures to response. Japan should consider incorporation of INFCIRC/225/Rev.5 to its national laws and regulations putting in mind that it may have heavy influence and that Japan pledged to role leadership about nuclear security to international society. (author)

Offshore wind farms in the local community - a survey at Horns Rev wind farm. Background report; Havvindmoeller i lokalomraedet - en undersoegelse ved Horns Rev havmoellepark. Baggrundsrapport

Energy Technology Data Exchange (ETDEWEB)

Kuehn, S.

2005-07-15

This report is part of a socio-economic project about offshore wind farms' influence on the local community. The project is part of the monitoring programme in connection with the establishment of the offshore wind farms at Horns Rev and Nysted. The socio-economic project consists of a sociological and an environment-economic project. This report is part of the sociological project which has the purpose of identifying attitudes towards the wind farm before and after the erection with a view to identify possible changes in opinions and reasons for these changes. (BA)

Anticoking Coatings for High Temperature Petrochemical Reactors Revêtements pour réacteurs pétrochimiques à cokage réduit

Directory of Open Access Journals (Sweden)

Ropital F.

2006-12-01

Full Text Available Coke deposition is a major problem for several refinery and petrochemical processes, among which steam cracking for ethylene production. Decreasing coking rates will reduce decoking frequency and will also decrease heat transfer degradation. For these processes, a means of reducing coking phenomena is the application of anticoking coatings on the reactor walls. For this purpose a methodology was developed under a CEC Brite-Euram project with steam cracking as the main application. A first selection of the coatings and their techniques of deposition was performed according to their composition (non catalytic compounds, their resistance to carburization and oxidation and also according to the nature of the substrate. The feasibility of coating deposition was studied for small diameter furnace tubes and the techniques were perfected in particular with respect to the physicochemical characterization of the coatings and their resistance during thermal cycling and coking-decoking cycles. For the thermal cycling and the coking evaluation, industrial conditions were reproduced as closely as possible. For coking tests, a microreactor with complete mixing of the gas phase was developed for temperatures up to 950°C. The coking behavior of the coated samples was compared with conventional refractory alloys: reduction of the coking rate by a factor of 3 was measured with the most promising coating. This work was completed by the kinetic modelling of coking on uncoated materials. La formation de coke est un problème crucial pour de nombreux procédés pétrochimiques. Ralentir le cokage permet de réduire la fréquence des décokages et de limiter la dégradation du transfert thermique. Un des moyens envisageables pour réduire le cokage est le dépôt d'un revêtement à la paroi de ces réacteurs. La mise au point de tels revêtements a fait l'objet d'un projet de recherche européen Brite-Euram, pour lequel le vapocraquage a été la principale

The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles

Directory of Open Access Journals (Sweden)

Ma Hong

2011-06-01

Full Text Available Abstract Background The process of HIV-1 genomic RNA (gRNA encapsidation is governed by a number of viral encoded components, most notably the Gag protein and gRNA cis elements in the canonical packaging signal (ψ. Also implicated in encapsidation are cis determinants in the R, U5, and PBS (primer binding site from the 5' untranslated region (UTR. Although conventionally associated with nuclear export of HIV-1 RNA, there is a burgeoning role for the Rev/RRE in the encapsidation process. Pleiotropic effects exhibited by these cis and trans viral components may confound the ability to examine their independent, and combined, impact on encapsidation of RNA into HIV-1 viral particles in their innate viral context. We systematically reconstructed the HIV-1 packaging system in the context of a heterologous murine leukemia virus (MLV vector RNA to elucidate a mechanism in which the Rev/RRE system is central to achieving efficient and specific encapsidation into HIV-1 viral particles. Results We show for the first time that the Rev/RRE system can augment RNA encapsidation independent of all cis elements from the 5' UTR (R, U5, PBS, and ψ. Incorporation of all the 5' UTR cis elements did not enhance RNA encapsidation in the absence of the Rev/RRE system. In fact, we demonstrate that the Rev/RRE system is required for specific and efficient encapsidation commonly associated with the canonical packaging signal. The mechanism of Rev/RRE-mediated encapsidation is not a general phenomenon, since the combination of the Rev/RRE system and 5' UTR cis elements did not enhance encapsidation into MLV-derived viral particles. Lastly, we show that heterologous MLV RNAs conform to transduction properties commonly associated with HIV-1 viral particles, including in vivo transduction of non-dividing cells (i.e. mouse neurons; however, the cDNA forms are episomes predominantly in the 1-LTR circle form. Conclusions Premised on encapsidation of a heterologous RNA into

Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S.B.

2000-03-15

An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S B

2000-03-15

An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

Science.gov (United States)

2013-05-13

...] Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not Withdrawn From Sale... ophthalmic solution), 0.5%, was not withdrawn from sale for reasons of safety or effectiveness. This... ophthalmic solution, 0.5%, if all other legal and regulatory requirements are met. FOR FURTHER INFORMATION...

Administrative circulars No. 22A (rev. 1) – Award of additional periods of membership in the Pensions Fund for long-term shift work and No. 22B (rev. 1) – Compensation for long-term shift work hours

CERN Multimedia

HR Department

2011-01-01

Administrative Circulars No. 22A (Rev. 1) entitled "Award of additional periods of membership in the Pension Fund for long-term shift work" and No. 22B (Rev.1) entitled “Compensation for long-term shift work hours”, adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 March 2011, are available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp They cancel and replace Administrative Circulars No. 22A and 22B entitled "Award of additional periods of membership in the Pension Fund to shift workers (Early Departure)” and “Duration and special compensation for shift work” of January 2000. This new version clarifies, in particular, the compensation of effective long-term shift work hours. Department Head Office  

Resposta imunitária à vacinação conjuntival com a estirpe Rev.1 de Brucella melitensis em ovinos e caprinos Serological response of sheep and goats to conjunctival Brucella melitensis Rev.1 vaccine

Directory of Open Access Journals (Sweden)

P. Poeta

2003-04-01

Full Text Available The live B. melitensis Rev.1 strain is considered the best vaccine available for the prophylaxis of brucellosis in small ruminants, especially when used at the standard dose by the conjunctival route. In the present study a 1´ 10(9 CFU dose for both sheep and goats conjunctivally vaccinated was tested to evaluate the duration of serological responses. Conjunctival vaccination with Rev. 1 performed in adult animals induced a rapid rise in serological titres as measured by Rose Bengal Plate Test (RBPT, Complement Fixation Test (CF and Modified Rose Bengal Plate Test (MRBPT. Titres then decreased and became negative in most animals by four months after vaccination (except MRBPT. The goats responded better to the vaccination than the sheep as one month after vaccination 100% of the goats revealed positive results to RB and RBM and 93.4% to FC test. The RBM was the one that detected more positive animals along the study.

Analysis of mutagenic DNA repair in a thermoconditional mutant of Saccharomyces cerevisiae. IV. Influence of DNA replication and excision repair on REV2 dependent UV-mutagenesis and repair

Energy Technology Data Exchange (ETDEWEB)

Siede, W.; Eckardt, F.

1986-01-01

A double mutant being thermoconditionally defective in mutation induction as well as in repair of pre-lethal UV-induced DNA damage (rev2ts) and deficient in excision repair (rad3-2) was studied in temperature-shift experiments. The influence of inhibitors of DNA replication (hydroxyurea, aphidicolin) was determined. Additionally, an analysis of the dose-response pattern of mutation induction (mutation kinetics) at several ochre alleles was carried out. It was concluded that the UV-inducible REV2 dependent mutagenic repair process is not induced in excision-deficient cells. In excision-deficient cells, REV2 dependent mutation fixation is slow and mostly post-replicative though not dependent on DNA replication. The REV2 mediated mutagenic process could be separated from the repair function.

Finanšu pārskata revīzija un tās gaita uzņēmumā SIA “X”

OpenAIRE

Pocjus, Evita

2016-01-01

Diplomdarba tēma: „Finanšu pārskata revīzija un tās gaita uzņēmumā SIA „X”” Finanšu pārskata revīzija ir būtiska, jo arī Latvijas Zvērināto revidentu asociācijas apkopotie statistikas dati norāda, ka Latvijā ~90% no pirmreizēji revidētiem uzņēmumiem tiek atklātas būtiskas neatbilstības grāmatvedības uzskaitē, tās atbilstībai LR likumiem un normatīviem aktiem, kā arī finanšu pārskata sagatavošanā. Finanšu pārskata revīzija ir nepieciešama katram uzņēmumam, kurš grib iegūt klientu un sadarbība...

Validation of CATHENA MOD-3.5/Rev0 for single-phase water hammer

International Nuclear Information System (INIS)

Beuthe, T.G.

2000-01-01

This paper describes work performed to validate the system thermalhydraulics code CATHENA MOD-3.5c/Rev0 for single-phase water hammer. Simulations were performed and are compared quantitatively against numerical tests and experimental results from the Seven Sisters Water Hammer Facility to demonstrate CATHENA can predict the creation and propagation of pressure waves when valves are opened and closed. Simulations were also performed to show CATHENA can model the behaviour of reflected and transmitted pressure waves at area changes, dead ends, tanks, boundary conditions, and orifices in simple and more complex piping systems. The CATHENA results are shown to calculate pressure and wave propagation speeds to within 0.2% and 0.5% respectively for numerical tests and within 3.3% and 5% for experimental results respectively. These results are used to help validate CATHENA for use in single-phase water hammer analysis. They also provide assurance that the fundamental parameters needed to successfully model more complex forms of water hammer are accounted for in the MOD-3.5c/Rev0 version of CATHENA, and represent the first step in the process to validate the code for use in modelling two-phase water hammer and condensation-induced water hammer. (author)

A numerical-statistical approach to determining the representative elementary volume (REV of cement paste for measuring diffusivity

Directory of Open Access Journals (Sweden)

Zhang, M. Z.

2010-12-01

Full Text Available Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV, in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First, several series of 3D cement paste microstructures were generated with HYMOSTRUC3D, a cement hydration and microstructure model, for different volumes of cement paste and w/c ratios ranging from 0.30 to 0.60. Second, the finite element method was used to simulate the diffusion of tritiated water through these microstructures. Effective cement paste diffusivity values for different REVs were obtained by applying Fick’s law. Finally, statistical analysis was used to find the fluctuation in effective diffusivity with cement paste volume, from which the REV was then determined. The conclusion drawn was that the REV for measuring diffusivity in cement paste is 100x100x100 μm³.

La difusividad del hormigón depende de su microestructura a numerosas escalas, desde nanómetros hasta milímetros, por lo que se precisa de técnicas multiescala para representar este parámetro. Junto con el principio de homogeneización, uno de los métodos multiescala más habituales es el volumen elemental representativo (VER. El objeto de este estudio era establecer un procedimiento que permitiera determinar el VER necesario para calcular la difusividad de la pasta de cemento, basándose en un método numéricoestadístico que consta de tres etapas. Primero, se crearon varias series de microestructuras de pasta de cemento en 3D con HYMOSTRUC3D, un programa que permite crear un modelo de la hidratación y microestructura del cemento. Luego se empleó el método de

Final Report - DuraMelter 100 Tests to Support LAW Glass Formulation Correlation Development, VSL-06R6480-1, Rev. 0

Energy Technology Data Exchange (ETDEWEB)

Kruger, Albert A.; Muller, I. S.; Gong, W.; Pegg, I. L.; Matlack, K. S.

2013-12-03

This report describes the results of work and testing specified by Test Specifications 24590-LAW-TSP-RT-04-004, Rev. 0, Test Plans VSL-05T5480-1, Rev. 0 and Text Exceptions 24590-LAW-TEF-RT-05-00002. The work and any associated testing followed established quality assurance requirements and was conducted as authorized. The descriptions provided in this test report are an accurate account of both the conduct of the work and the data collected. Results required by the Test Plan are reported. Also reported are any unusual or anomalous occurences that are different from the starting hypotheses. The test results and this report have been reviewed and verified.

A novel, mouse mammary tumor virus encoded protein with Rev-like properties

International Nuclear Information System (INIS)

Indik, Stanislav; Guenzburg, Walter H.; Salmons, Brian; Rouault, Francoise

2005-01-01

We have identified a novel, multiple spliced, subgenomic mRNA species in MMTV producing cells of different origin containing an open reading frame encoding a 39-kDa Rev-like protein, Rem (regulator of expression of MMTV). An EGFP-Rem fusion protein is shown to be predominantly in the nucleolus. Further leptomycin B inhibits the nuclear export of nonspliced MMTV transcripts, implicating Rem in nuclear export by the Crm1 pathway in MMTV. Rem is thus reminiscent of the Rec protein from the related endogenous human retrovirus, HERV-K

Permeability computation on a REV with an immersed finite element method

International Nuclear Information System (INIS)

Laure, P.; Puaux, G.; Silva, L.; Vincent, M.

2011-01-01

An efficient method to compute permeability of fibrous media is presented. An immersed domain approach is used to represent the porous material at its microscopic scale and the flow motion is computed with a stabilized mixed finite element method. Therefore the Stokes equation is solved on the whole domain (including solid part) using a penalty method. The accuracy is controlled by refining the mesh around the solid-fluid interface defined by a level set function. Using homogenisation techniques, the permeability of a representative elementary volume (REV) is computed. The computed permeabilities of regular fibre packings are compared to classical analytical relations found in the bibliography.

Visual and radar observations of birds in relation to collision risk at the Horns Rev offshore wind farm. Annual status report 2003

Energy Technology Data Exchange (ETDEWEB)

Kjaer Christensen, T.; Hounisen, J.P.; Clausager, I.; Krag Petersen, I.

2004-07-01

The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. In 2003 the studies focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging species. The Horns Rev area lies in a region known to be important for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

Reliability of Concentric, Eccentric and Isometric Knee Extension and Flexion when using the REV9000 Isokinetic Dynamometer

DEFF Research Database (Denmark)

de Carvalho Froufe Andrade, Alberto César Pereira; Caserotti, Paolo; de Carvalho, Carlos Manuel Pereira

2013-01-01

The aim of this study was to assess the reliability of isokinetic and ISO knee extensor and flexor muscle strength when using the REV9000 (Technogym) isokinetic dynamometer. Moreover, the reliability of several strength imbalance indices and bilateral ratios were also examined. Twenty-four physic...

Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes

Directory of Open Access Journals (Sweden)

Mohammad Ebrahimi

2012-12-01

Full Text Available Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 106, 106, 5 × 105. Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 106 Rev. 1 organisms than in those which received 106 or 5 × 105 bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 106 or 5 × 105 live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

Operational Circular No.2 (Rev. 2) - Conditions of access to the fenced parts of the CERN site

CERN Multimedia

2014-01-01

Operational Circular No. 2 (Rev. 2) entitled “Conditions of access to the fenced parts of the CERN site” and its “implementation measures”, approved by the Director-General following discussion at the Standing Concertation Committee meeting on 20 May 2014 and entering into force on 1 September 2014, are available on the intranet site of the Human Resources Department (see here).   This circular is applicable to members of the personnel and other persons concerned. It cancels and replaces Operational Circular No. 2 (Rev. 1) entitled “Conditions of access to the fenced parts of the CERN site”, of April 1998. In particular, the revised circular provides for the possibility of mandating a person responsible for the proper implementation of the circular, specifies the rules relating to vehicles allowed on the site and the respective responsibilities of their owners, and relaxes certain administrative formalities in case of loss, theft or di...

Operational Circular No. 2 (Rev. 3) - Conditions of access to the fenced parts of the CERN site

CERN Multimedia

HR Department

2015-01-01

Operational Circular No. 2 (Rev. 3) entitled "Conditions of access to the fenced parts of the CERN site", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 24 September 2015, is now available via this link.   This revised circular cancels and replaces Operational Circular No. 2 (Rev. 2) also entitled "Conditions of access to the fenced parts of the CERN site", of September 2014. The circular was revised predominantly in order to specify that access to the CERN site is granted to CERN Pension Fund beneficiaries only provided that they are actually in receipt of payments from the Fund; and to allow the Director-General to permit special types of vehicles on site, such as trailers. It also includes a certain number of text improvements and an updated version of the implementation measures, in particular with regard to vehicle identification, road traffic and parking.  

IMMUNE RESPONSES OF GOATS (SHAMI BREED TO VACCINATION WITH A FULL, REDUCED AND CONJUNCTIVAL DOSE OF BRUCEVAC (BRUCELLA MELITENSIS REV.1 VACCINE

Directory of Open Access Journals (Sweden)

F. ALDOMY, M. ALKHAWALDEH1 AND I. B. YOUNIS

2009-10-01

Full Text Available Three groups of Shami goats were randomly vaccinated with Brucevac (Rev. 1 vaccine. Group 1 was vaccinated subcutaneously with a full dose (1.54 x 109 organisms. Group 2 was vaccinated conjunctively with one eye drop (5.2 x 108 organisms, while Group 3 was injected subcutaneously with a reduced dose (7.1 x 105 organisms of vaccine. Blood samples were collected before vaccination, two, four, eight, 15 and 24 weeks post vaccination. All samples were tested through CFT, ELISA, SAT and Rose Bengal plate test. All serological tests used detected a higher percentage of vaccinated female kids with a full dose than they did in other groups vaccinated with a reduced dose or with a conjunctival dose of Rev.1 vaccine. The overall results suggested that 100% of animals vaccinated with a conjunctival dose became positive to CFT at two, four, eight and 15 weeks post vaccination, and then the percentage of seropositive animals declined and became 20% at 24 weeks post inoculation. The conjunctival route of vaccination significantly reduced the intensity and duration of the post vaccination serological response, which makes the use of this vaccine compatible with brucellosis programmes, even when these are based on a test-and–slaughter policy. The overall results showed that Shami goats responded to Rev.1 vaccine in the expected way. The majority of animals were seropositive to the CFT by two weeks after vaccination with higher numbers of seropositive animals in the kids group vaccinated with a full dose of Rev.1 vaccine.

Effects on birds of an offshore wind park at Horns Rev: Environmental impact assessment

Energy Technology Data Exchange (ETDEWEB)

Noer, H.; Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [DMU, Dept. of Coastal Zone Ecology (Denmark)

2000-07-01

This report presents the technical background to the ornithological environmental impact assessment for the construction of an offshore windpark at Horns Rev, 14 km west-south-west of Blaevandshuk, Denmark. Construction of the park is planned to commence in 2001. The park will consist of c. 80 wind turbines, each of at least 1.8 MW, and cover an area of 27.5 km{sup 2} (including the 200 m exclusion zone around the park). (au)

Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal human tissue

NARCIS (Netherlands)

Parmentier, H. K.; van Wichen, D. F.; Meyling, F. H.; Goudsmit, J.; Schuurman, H. J.

1992-01-01

The expression of regulatory proteins tat, rev, and nef of human immunodeficiency virus type-1 (HIV-1) and tat of HIV-2 was studied in frozen sections of lymph nodes from HIV-1-infected individuals, and various tissues from uninfected persons. In HIV-1-positive lymph nodes, monoclonal antibodies to

Expression of the clock gene Rev-erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism

NARCIS (Netherlands)

Sen, Satish; Dumont, Stéphanie; Sage-Ciocca, Dominique; Reibel, Sophie; de Goede, Paul; Kalsbeek, Andries; Challet, Etienne

2018-01-01

The nuclear receptor REV-ERBα is part of the molecular clock mechanism and is considered to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Science.gov (United States)

Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

2010-11-01

Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

78 FR 11907 - Notice of Forthcoming Workshop To Discuss Revisions to NUREG/BR-0204, Rev. 2 “Instructions for...

Science.gov (United States)

2013-02-20

... radioactive waste disposal facilities if over-estimated. Additionally, the NRC staff received comments from... Performance Assessment Methodology for Low-Level Radioactive Waste Disposal Facilities'' (ADAMS Accession No..., Rev. 2 ``Instructions for Completing NRC's Uniform Low-Level Radioactive Waste Manifest.'' Information...

Wind Farm Wake: The Horns Rev Photo Case

Directory of Open Access Journals (Sweden)

Pierre-Elouan Réthoré

2013-02-01

Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

HRensembleHR. High resolution ensemble for Horns Rev. Final project report. Executive summary; Offshore wind power

Energy Technology Data Exchange (ETDEWEB)

2010-03-15

The development of offshore wind power results in more energy production per area unit and new requirements to the generation forecasts. Measurements from Horns Rev and ensemble forecasts were used to upgrade forecasting tools for the relevant periods and time scales. The most significant development is a new algorithm for short-term forecasts that combines any relevant online measurements by means of ensemble forecasts. (ln)

Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

DEFF Research Database (Denmark)

Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth

2017-01-01

(ADP) ribose polymerase 1 (PARP1) activity, low endogenous NAD+, low expression of SIRT1 and PGC1α and low adenosine monophosphate (AMP)-activated kinase (AMPK) activity. We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via...... the PARP-NAD+-SIRT1-PGC1α axis....

Numerical Modelling of Large-Diameter Steel Piles at Horns Rev

DEFF Research Database (Denmark)

Augustesen, Anders Hust; Brødbæk, K. T.; Møller, M.

2009-01-01

Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used as founda......Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used...... as foundation for a wind turbine at Horns Rev located in the Danish sector of the North Sea. The outer diameter of the pile is 4 m and the subsoil at the location consists primarily of sand. The behaviour of the pile is investigated under realistic loading conditions by means of a traditional Winkler...

ADMINISTRATIVE CIRCULAR No. 25 (REV. 3) - Special provisions for the fire and rescue service governing working and rest time

CERN Multimedia

2012-01-01

Administrative Circular No. 25 (Rev. 3) entitled “Special provisions for the Fire and Rescue Service governing working and rest time”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 28 September 2012 and entering into force in October 2012, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp This Circular is applicable to staff members of the Fire and Rescue Service It cancels and replaces Administrative Circular No. 25 (Rev. 2) entitled “Shift work – Special provisions for the Fire and Rescue Service” of April 2003. This new version takes into account the new organisation of the Fire and Rescue Service, members of which will henceforth not exclusively perform their functions in the context of shift work, but also during reference working hours and during stand-by duty. Additionally, applicable limits regarding working and rest times an...

REMINDER: Compliance with Operational Circular No. 2 (Rev. 1) on “Conditions of access to the fenced CERN site”

CERN Multimedia

2012-01-01

The purpose of Operational Circular No. 2 (Rev. 1) is to contribute to the protection of people and property by defining the conditions of access to the Organization's fenced sites. The behaviours that cannot be tolerated under any circumstances are: use of CERN access cards by people, other than the cardholders themselves, in order to gain access to facilities without having attended the required safety course; speeding, particularly on Route Gregory and Route Weisskopf; driving in and out of the site on the wrong side of the road; parking on spaces set aside for the disabled; nuisance parking, especially in the proximity of the restaurants; dumping of wrecked vehicles. As the aforementioned instances of non-compliance can lead to dangerous situations, the Organization reserves the right to apply the penalties provided for under paragraph 26 of Operational Circular No. 2 (Rev. 1), namely to refuse access to the site to people and/or their vehicles deemed to be in infringement of the circu...

Administrative circular n°3 (Rev. 2) – Home leave, travel to home station and assimilated leave and travel

CERN Multimedia

2013-01-01

Administrative Circular No. 3 (Rev. 2) entitled “Home leave, travel to the home station and assimilated leave and travel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to employed members of the personnel. It cancels and replaces Administrative Circular No. 3 (Rev. 1) entitled “Travel to the home station and home leave” of June 2002. The circular was revised in order to take into account the new status of Associate Member State and the fact that henceforth, home stations may be situated on territory outside of Europe. It is proposed to introduce a new system of determination of the benefits (Travel expenses, travel time and distance indemnity) granted in the context of home leave and supplementary journeys to the home station.  For t...

Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBα/NCoR.

Science.gov (United States)

Westermaier, Yvonne; Ruiz-Carmona, Sergio; Theret, Isabelle; Perron-Sierra, Françoise; Poissonnet, Guillaume; Dacquet, Catherine; Boutin, Jean A; Ducrot, Pierre; Barril, Xavier

2017-08-01

The knowledge of the free energy of binding of small molecules to a macromolecular target is crucial in drug design as is the ability to predict the functional consequences of binding. We highlight how a molecular dynamics (MD)-based approach can be used to predict the free energy of small molecules, and to provide priorities for the synthesis and the validation via in vitro tests. Here, we study the dynamics and energetics of the nuclear receptor REV-ERBα with its co-repressor NCoR and 35 novel agonists. Our in silico approach combines molecular docking, molecular dynamics (MD), solvent-accessible surface area (SASA) and molecular mechanics poisson boltzmann surface area (MMPBSA) calculations. While docking yielded initial hints on the binding modes, their stability was assessed by MD. The SASA calculations revealed that the presence of the ligand led to a higher exposure of hydrophobic REV-ERB residues for NCoR recruitment. MMPBSA was very successful in ranking ligands by potency in a retrospective and prospective manner. Particularly, the prospective MMPBSA ranking-based validations for four compounds, three predicted to be active and one weakly active, were confirmed experimentally.

Upper Bound Radiation Dose Assessment for Military Personnel at McMurdo Station, Antarctica, between 1962 and 1979 (2REV)

Science.gov (United States)

2017-09-30

N IC A L R EP O R T Defense Threat Reduction Agency 8725 John J. Kingman Road , MS-6201 Fort Belvoir, VA 22060-6201 STANDARD FORM 298 (Rev. 8/98...8725 John J. Kingman Road , Mail Stop 6201 Fort...Early Operation ..................................................................................... 5 2.2 Operations and Maintenance

75 FR 75486 - Maritime Security Directive 104-6 (Rev. 4); Guidelines for U.S. Vessels Operating in High Risk...

Science.gov (United States)

2010-12-03

... Directive 104-6 (Rev. 4); Guidelines for U.S. Vessels Operating in High Risk Waters AGENCY: Coast Guard, DHS... Maritime Transportation Security Act (MTSA) on international voyages through or in designated high risk... MARSEC Directives are available at your local Captain of the Port (COTP) office. Phone numbers and...

OPERATIONAL CIRCULAR NO2 (REV. 1) - APRIL 1998 'CONDITIONS OF ACCESS TO THE FENCED PARTS OF THE CERN SITE'

CERN Multimedia

Human Resources Division

2001-01-01

Subsidiary document 'Implementation Measures' (Rev. 2) - April 2001 The subsidiary document has been amended. Copies are available from Divisional Secretariats and at CERN card issue points. Note : Administrative and operational circulars, as well as the lists of those in force, are available for consultation on WWW : ADMINISTRATIVE CIRCULARS OPERATIONAL CIRCULARS

Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-10-15

The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

Review report 2003. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-09-15

The present review report presents the two wind farms Homs Rev and Nysted, with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on methods, programmes and conclusions can be found in these reports. This review report is divided into two parts. The first part contains a description of the potential environmentally impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Hors Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated at the bdsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-10-15

The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα

Directory of Open Access Journals (Sweden)

Brown M Scott

2010-12-01

Full Text Available Abstract Background Alternative processing of α-thyroid hormone receptor (TRα, NR1A1 mRNAs gives rise to two functionally antagonistic nuclear receptors: TRα1, the α-type receptor, and TRα2, a non-hormone binding variant that is found only in mammals. TRα2 shares an unusual antisense coding overlap with mRNA for Rev-erbα (NR1D1, another nuclear receptor protein. In this study we examine the structure and expression of these genes in the gray short-tailed opossum, Monodelphis domestica, in comparison with that of eutherian mammals and three other marsupial species, Didelphis virginiana, Potorous tridactylus and Macropus eugenii, in order to understand the evolution and regulatory role of this antisense overlap. Results The sequence, expression and genomic organization of mRNAs encoding TRα1 and Rev-erbα are very similar in the opossum and eutherian mammals. However, the sequence corresponding to the TRα2 coding region appears truncated by almost 100 amino acids. While expression of TRα1 and Rev-erbα was readily detected in all tissues of M. domestica ages 0 days to 18 weeks, TRα2 mRNA was not detected in any tissue or stage examined. These results contrast with the widespread and abundant expression of TRα2 in rodents and other eutherian mammals. To examine requirements for alternative splicing of TRα mRNAs, a series of chimeric minigenes was constructed. Results show that the opossum TRα2-specific 5' splice site sequence is fully competent for splicing but the sequence homologous to the TRα2 3' splice site is not, even though the marsupial sequences are remarkably similar to core splice site elements in rat. Conclusions Our results strongly suggest that the variant nuclear receptor isoform, TRα2, is not expressed in marsupials and that the antisense overlap between TRα and Rev-erbα thus is unique to eutherian mammals. Further investigation of the TRα and Rev-erbα genes in marsupial and eutherian species promises to yield

Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα

Science.gov (United States)

2010-01-01

Background Alternative processing of α-thyroid hormone receptor (TRα, NR1A1) mRNAs gives rise to two functionally antagonistic nuclear receptors: TRα1, the α-type receptor, and TRα2, a non-hormone binding variant that is found only in mammals. TRα2 shares an unusual antisense coding overlap with mRNA for Rev-erbα (NR1D1), another nuclear receptor protein. In this study we examine the structure and expression of these genes in the gray short-tailed opossum, Monodelphis domestica, in comparison with that of eutherian mammals and three other marsupial species, Didelphis virginiana, Potorous tridactylus and Macropus eugenii, in order to understand the evolution and regulatory role of this antisense overlap. Results The sequence, expression and genomic organization of mRNAs encoding TRα1 and Rev-erbα are very similar in the opossum and eutherian mammals. However, the sequence corresponding to the TRα2 coding region appears truncated by almost 100 amino acids. While expression of TRα1 and Rev-erbα was readily detected in all tissues of M. domestica ages 0 days to 18 weeks, TRα2 mRNA was not detected in any tissue or stage examined. These results contrast with the widespread and abundant expression of TRα2 in rodents and other eutherian mammals. To examine requirements for alternative splicing of TRα mRNAs, a series of chimeric minigenes was constructed. Results show that the opossum TRα2-specific 5' splice site sequence is fully competent for splicing but the sequence homologous to the TRα2 3' splice site is not, even though the marsupial sequences are remarkably similar to core splice site elements in rat. Conclusions Our results strongly suggest that the variant nuclear receptor isoform, TRα2, is not expressed in marsupials and that the antisense overlap between TRα and Rev-erbα thus is unique to eutherian mammals. Further investigation of the TRα and Rev-erbα genes in marsupial and eutherian species promises to yield additional insight into the

Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

Institute of Scientific and Technical Information of China (English)

LIU Xiao-feng; GU Jian; YANG Hong-wen

2008-01-01

This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

Base-line investigations of birds in relation to an offshore wind farm at Horns Rev, and results from the year of construction

Energy Technology Data Exchange (ETDEWEB)

Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

2003-04-15

The present report presents the base-line investigations of birds conducted during August 1999-April 2001 in relation to construction of an offshore wind farm at Horns Rev, 14 km west-south-west of Blaevandshuk, in the Danish North Sea. The report also presents data collected during the period September 2001-April 2002, when construction of the wind farm was in progress. The wind farm will consist of 80 wind turbines, each of 2 MW, and cover an area of c. 20 km{sup 2}. The eastern part of the North Sea constitutes major staging and wintering grounds for huge numbers of water- and seabirds. The area is also known to be an important site for migrating birds, which especially in autumn pass in large numbers. As Denmark has obligations to protect and maintain the bird populations it was laid down in the approval for erection of the wind farm that the impact on birds should be investigated. According to the 1% criteria defined in the Ramsar Convention, the eastern part of the North Sea including the wind farm area is of international importance to divers, Common Tern, and Sandwich Tern. A number of other species, e.g. Common Eider, Common Scoter, Guillemot and Razorbill, are present in the area in significant numbers as well, though these numbers do not make up 1% of the populations. Detailed distributions of birds in the area around and at Horns Rev were virtually unknown until initiation of this project. Previous bird counts in this area have been carried out almost exclusively from the coast and detailed knowledge exists concerning the numbers of roosting at and migrating birds from the westernmost point of Jutland, Blaevandshuk. To describe the numbers and distributions of birds staging and wintering in the Horns Rev area, bird investigations were initiated in 1999 by using standardised transect counts from aircraft. Up to April 2002, 18 aerial counts have been carried out over an area of c. 1,700 km{sup 2} centred on the Horns Rev project area. (au)

Base-line investigations of birds in relation to an offshore wind farm at Horns Rev, and results from the year of construction

International Nuclear Information System (INIS)

Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

2003-01-01

The present report presents the base-line investigations of birds conducted during August 1999-April 2001 in relation to construction of an offshore wind farm at Horns Rev, 14 km west-south-west of Blaevandshuk, in the Danish North Sea. The report also presents data collected during the period September 2001-April 2002, when construction of the wind farm was in progress. The wind farm will consist of 80 wind turbines, each of 2 MW, and cover an area of c. 20 km 2 . The eastern part of the North Sea constitutes major staging and wintering grounds for huge numbers of water- and seabirds. The area is also known to be an important site for migrating birds, which especially in autumn pass in large numbers. As Denmark has obligations to protect and maintain the bird populations it was laid down in the approval for erection of the wind farm that the impact on birds should be investigated. According to the 1% criteria defined in the Ramsar Convention, the eastern part of the North Sea including the wind farm area is of international importance to divers, Common Tern, and Sandwich Tern. A number of other species, e.g. Common Eider, Common Scoter, Guillemot and Razorbill, are present in the area in significant numbers as well, though these numbers do not make up 1% of the populations. Detailed distributions of birds in the area around and at Horns Rev were virtually unknown until initiation of this project. Previous bird counts in this area have been carried out almost exclusively from the coast and detailed knowledge exists concerning the numbers of roosting at and migrating birds from the westernmost point of Jutland, Blaevandshuk. To describe the numbers and distributions of birds staging and wintering in the Horns Rev area, bird investigations were initiated in 1999 by using standardised transect counts from aircraft. Up to April 2002, 18 aerial counts have been carried out over an area of c. 1,700 km 2 centred on the Horns Rev project area. (au)

Evolution of ASTEC V1.2 rev.1 code for WWER-1000 reactors/SBO sequence

International Nuclear Information System (INIS)

Georgieva, J.; Stefanova, A.; Groudev, P.; Tusheva, P.; Kalchev, B.; Passalacqua, R.

2006-01-01

In this paper a comparison between calculations of severe accidents occurred from WWER-1000 with ASTEC code specified for an event of full unloading with relief valves stuck opened with no hydroaccumulators intervention is presented. The purpose of the analyses provided is to present the relationship between the improvements of the actual version (ASTEC Vl.2 rev. 1) and ASTEC V1.1 p2 like: code modifications, incoming data improvements. Such discrepancies are to be examined. Case by case suggestions for ASTEC improvements are to be provided

A Comprehensive Experiment for Molecular Biology: Determination of Single Nucleotide Polymorphism in Human REV3 Gene Using PCR-RFLP

Science.gov (United States)

Zhang, Xu; Shao, Meng; Gao, Lu; Zhao, Yuanyuan; Sun, Zixuan; Zhou, Liping; Yan, Yongmin; Shao, Qixiang; Xu, Wenrong; Qian, Hui

2017-01-01

Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of…

Numerical modelling of powder caking at REV scale by using DEM

Science.gov (United States)

Guessasma, Mohamed; Silva Tavares, Homayra; Afrassiabian, Zahra; Saleh, Khashayar

2017-06-01

This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM). In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV), the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation) in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength).

Numerical modelling of powder caking at REV scale by using DEM

Directory of Open Access Journals (Sweden)

Guessasma Mohamed

2017-01-01

Full Text Available This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM. In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV, the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength.

Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-10-15

As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind

Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

International Nuclear Information System (INIS)

2002-10-01

As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind farm

76 FR 2402 - Maritime Security Directive 104-6 (Rev 5); Guidelines for U.S. Vessels Operating in High Risk Waters

Science.gov (United States)

2011-01-13

... Directive 104-6 (Rev 5); Guidelines for U.S. Vessels Operating in High Risk Waters AGENCY: Coast Guard, DHS... designated high risk waters, and provides additional counter-piracy guidance and mandatory measures for these... MARSEC Directives are available at your local Captain of the Port (COTP) office. Phone numbers and...

Administrative Circular No. 2 (Rev. 6) – Recruitment, appointment and possible developments regarding the contractual position of staff members (1 January 2015)

CERN Multimedia

2014-01-01

Administrative Circular No. 2 (Rev. 6) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 November 2014 is available on the Human Resources Department website. It cancels and replaces Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2011. This circular was revised in order to improve the effectiveness of the career transition measures, in particular by expanding the scope of the programme to include also career transition within the Organization and by placing emphasis on career orientation and job search. Administrative Circular No. 2 will be further revised next year with the adoption of the new contract policy, subject to approval of the relevant amendments by all competent bodies. ...

Simulaton of the Avedøreværket Unit 1 Cogeneration Plant with DNA

DEFF Research Database (Denmark)

Elmegaard, Brian; Houbak, Niels

2003-01-01

The simulator contest proposed for the ECOS 2003 conference has been solved using the DNA energy system simulator. The contest concerns the steam process of the Avedøreværket Unit 1 (AVV1) power plant. The plant is a 250 MWCHP plant with a maximum district heat production of 330 MJ/s. The plant has...... a net electric efficiency of 42% and a maximum energy utilization of 92%. In this paper it is demonstrated, that the DNA model of AVV1 can calculate the whole flow sheet balance at any load point, i.e., any possible combination of power production and district heat production. The paper also contains...

Fundamental study on REV based on crack tensor at the Mizunami Underground Research Laboratory

International Nuclear Information System (INIS)

Tanno, Takeo; Sato, Toshinori; Sanada, Hiroyuki; Hikima, Ryoichi; Kumasaka, Hiroo; Tada, Hiroyuki

2013-01-01

The crack tensor model which is a kind of equivalent continuum model has been studied in rock mechanical investigation in the MIU. The fractured rock mass is modeled as the elastic continuum model with this crack tensor. In this study, this crack tensor based on the geological observation in the MIU project was calculated, and Representative Elementary Volume (REV) in the ventilation shaft and -300 m access/research gallery was studied based on the relative error of this crack tensor. As a result, the convergence of the relative error was faster in the -300 m access/research gallery than in the ventilation shaft. (author)

Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression

International Nuclear Information System (INIS)

Nguyen, Kim-Lien; Llano, Manuel; Akari, Hirofumi; Miyagi, Eri; Poeschla, Eric M.; Strebel, Klaus; Bour, Stephan

2004-01-01

Two HIV-1 accessory proteins, Vpu and Vif, are notoriously difficult to express autonomously in the absence of the viral Tat and Rev proteins. We examined whether the codon bias observed in the vpu and vif genes relative to highly expressed human genes contributes to the Rev dependence and low expression level outside the context of the viral genome. The entire vpu gene as well as the 5' half of the vif gene were codon optimized and the resulting open reading frames (ORFs) (vphu and hvif, respectively) were cloned in autonomous expression vectors under the transcriptional control of the CMV promoter. Codon optimization efficiently removed the expression block observed in the native genes and allowed high levels of Rev- and Tat-independent expression of Vpu and Vif. Most of the higher protein levels detected are accounted for by enhanced steady-state levels of the mRNA encoding the optimized species. Nuclear run-on experiments show for the first time that codon optimization has no effect on the rate of transcriptional initiation or elongation of the vphu mRNA. Instead, optimization of the vpu gene was found to stabilize the vphu mRNA in the nucleus and enhance its export to the cytoplasm. This was achieved by allowing the optimized mRNA to use a new CRM1-independent nuclear export pathway. This work provides a better understanding of the molecular mechanisms underlying the process of codon optimization and introduces novel tools to study the biological functions of the Vpu and Vif proteins independently of other viral proteins

Bird numbers and distributions in the Horns Rev offshore wind farm area. Annual status report 2004

Energy Technology Data Exchange (ETDEWEB)

Krag Petersen, I.

2005-07-01

This report presents data from four aerial surveys of birds in the Horns Rev wind farm area in 2004. Three surveys from the winter and spring of 2004 are thoroughly reported here. The fourth survey of 9 September 2004 is reported in general terms, but not included in presentations of distribution and effect analyses of the wind farm. Data from this survey will be thoroughly dealt with in a future report. Including the four surveys of 2004, a total of 29 surveys have been performed in that area since August 1999. (au)

Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

International Nuclear Information System (INIS)

Bech, M.; Leonhars, S.B.; Pedersen, John

2004-05-01

ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

Energy Technology Data Exchange (ETDEWEB)

Bech, M.; Leonhars, S.B.; Pedersen, John

2004-05-15

ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

Post-construction evaluation of bird abundances and distributions in the Horns Rev 2 offshore wind farm area, 2011 and 2012

DEFF Research Database (Denmark)

Petersen, Ib Krag; Nielsen, Rasmus Due; Mackenzie, Monique L.

2014-01-01

Optællinger af fugle fra fly efter linjetransekt-metoden blev anvendt til at beskrive fuglenes antal og udbredelse i undersøgelsesområdet. Ti optællinger før Horns Rev 2 mølleparkens opførelse blev sammenlignet med ti optællinger foretaget efter parkens etablering. Rumlig modellering blev anvendt...

Evaluation of vaccination strategies against infection with feline immunodeficiency virus (FIV) based on recombinant viral vectors expressing FIV Rev and OrfA

NARCIS (Netherlands)

Huisman, W.; Schrauwen, E.J.A.; Tijhaar, E.; Süzer, Y.; Pas, S.D.; Amerongen, van G.; Sutter, G.; Rimmelzwaan, G.F.; Osterhaus, A.D.M.E.

2008-01-01

In recent years it has become clear that cell-mediated immunity is playing a role in the control of lentivirus infections. In particular, cytotoxic T lymphocyte responses have been associated with improved outcome of infection, especially those directed against the regulatory proteins like Rev and

Hard bottom substate monitoring Horns Rev offshore wind farm 2004. Survey report no. 1

Energy Technology Data Exchange (ETDEWEB)

Frederiksen, Rune

2004-05-15

In connection with the implementation of the monitoring programme concerning the ecological implication of the effect of the introduction of hard substrate related to the Horns Rev Wind Farm, the third survey was carried out in the period 2431 March 2004. The survey covered collection of fauna and flora samples from the scour protection and at the wind turbine towers at six turbine sites. Video recordings were planned at different sites to provide documentation, but due to poor visibility the video recordings were postponed. On request from Elsam Engineering A/S video inspections on technical installations were made at turbine '84 and 95. This report covers a short description of the methodology, sampling activities and site description. (au)

Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

CERN Multimedia

HR Department

2007-01-01

Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp These Circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover in particular lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you require any additional informa...

Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

CERN Multimedia

HR Department

2007-01-01

Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://https://hr-docs.web.cern.ch/hr-docs/admincirc/admincirc_fr.asp These circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover, in particular, lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you requi...

Comment on "Total Negative Refraction in Real Crystals for Ballistic Electrons and Light" (Phys. Rev. Lett. 91, 157404 (2003))

OpenAIRE

Yau, H. -F.; Liu, J. -P.; Ke, B.; Kuo, C. -H.; Ye, Z.

2003-01-01

Recently, Zhang et al. (Phys. Rev. Lett. 91, 157404 (2003)) have demonstrated that an amphoteric refraction, i. e. both positive and negative refraction, may prevail at the interface of two uniaxial anisotropic crystals when their optical axes are in different directions. The authors subsequently made a correspondence between such a refraction with the negative refraction expected for Left Handed Materials (LHMs). Here we comment that the amphoteric refraction can be observed even with one un...

Infauna monitoring Horns Rev offshore wind farm. Annual state report 2004

Energy Technology Data Exchange (ETDEWEB)

Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

2005-04-15

A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

Infauna monitoring Horns Rev offshore wind farm. Annual status report 2004

International Nuclear Information System (INIS)

Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

2005-04-01

A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-07-01

The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels.

Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

International Nuclear Information System (INIS)

1997-07-01

The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

Administrative circular No.14 (Rev. 3) – Protection of members of the personnel against the financial consequences of illness, accident and incapacity for work

CERN Multimedia

2013-01-01

Administrative Circular No. 14 (Rev. 3) entitled “Protection of members the personnel against the financial consequences of illness, accident and incapacity for work”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 19 April 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 14 (Rev. 2) entitled “Protection of members of the personnel against the financial consequences of illness, accident and disability” from July 2006. The circular was revised in order to improve the procedure before the Joint Advisory Rehabilitation and Disability Board (JARDB) and the management of long-term sick leave through a multidisciplinary approach launched upstream. The aim of this approach is to allow staff/fellows c...

Grate Pallet 8232 (GP-8232) Vehicle Pallet, Evaluation Tests MIL-STD-1660, "Design Criteria for Ammunition Unit Loads" and TP-94-01 (REV 1), "Transportability Testing Procedures"

National Research Council Canada - National Science Library

Barickman, Philip

2003-01-01

.... The testing was conducted for informational purposes only. The GP-8232 Vehicle Pallet was evaluated by the testing procedures set forth in MIL-STD-1660 and TP-94-01 (Rev. 1) testing procedures...

Mersin ilinde görev yapan hekimlerin meslek örgütüyle ilişkileri ve beklentileri

Directory of Open Access Journals (Sweden)

Ahmet Öner Kurt

2011-12-01

Full Text Available Amaç: Bu çalışmada; Mersin İlinde görev yapan hekimlerin meslek örgütü olan tabip odası ile ilişkilerinin boyutu ve odadan beklentilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Kesitsel tipteki bu çalışmada Mersin İlinde görev yapan toplam 1875 hekim evren olarak kabul edildi, örnek olarak 550 hekimin çalışmaya alınması hedeflendi. Çalışmaya alınacak hekimler; görev yeri, kurum, unvan ve cinsiyet oranına göre ağırlıklandırılarak tabakalı sistematik örnekleme yöntemi ile belirlendi. Veriler Kasım-Aralık 2009 tarihlerinde anket formu kullanılarak toplandı. Verilerin özetlenmesinde tanımlayıcı istatistikler ve değişkenlerin karşılaştırılmasında Ki-kare testi kullanıldı. Bulgular: Hekimlerin %69.1’i erkek, %82.5’i evli, %80.9’u kamu sağlık kurumlarında çalışıyor, %37.6’sı pratisyen hekim olarak görev yapıyordu. Hekimlerin ortalama görev süresi 17.4±9.6 (1–52 yıldı. Hekimlerin %77.1’i tabip odasına üye, %31.5’i son bir yılda tabip odası çalışmalarına katılmış ve %26.7’si bugünden sonraki süreçte tabip odası çalışmalarında görev almak istiyordu. Erkek, evli, özel sektörde çalışan, uzman olan, görev süresi 30 yıldan fazla olan ve çalışma koşullarının iyileştirilmesini bekleyen hekimlerin diğer gruplara göre tabip odasına daha fazla üye oldukları saptandı. Son bir yılda araştırma görevlileri tabip odası çalışmalarına daha az katılmıştı. Hekimlerin tabip odasından ilk sıradaki beklentisi; çalışma koşullarının iyileştirilmesiydi. Sonuç: Mersin’de dört hekimden birisinin tabip odasına üye olmaması, üçte ikisinin oda çalışmalarına katılmaması ve bugünden sonra da katılmayı düşünmemesi, hekimlerin örgütlü yaşamın gereklerini yeterince yerine getirmediğini ve meslek örgütlerine çok fazla sahip çıkmadığını düşündürmektedir. Tabip odaları üyelerinin odaya yakla

Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005)

International Nuclear Information System (INIS)

Seijas Portela, S.

2010-01-01

Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production

Science.gov (United States)

Na, Hong; Huisman, Willem; Ellestad, Kristofor K.; Phillips, Tom R.; Power, Christopher

2010-01-01

Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analyses were performed in both an infectious FIV molecular clone and a FIV CAT-RRE reporter system. These studies disclosed that the stems within SLA (SA1, 2, 3, 4, and 5) of the RRE were critical but SA6 was not essential for FIV replication and CAT expression. These studies also revealed that the secondary structure rather than an antisense protein (ASP) mediates virus expression and replication in vitro. In addition, a single synonymous mutation within the FIV-RRE, SA3/45, reduced viral reverse transcriptase activity and p24 expression after transfection but in addition also showed a marked reduction in viral expression and production following infection. PMID:20570310

Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities; Orientaciones y sugerencias para la aplicacion del documento INFCIRC/225/Rev.4, proteccion fisica de los materiales y las instalaciones nucleares

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-05-01

This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection.

Hydroacoustic registration of fish abundance of offshore wind farms. Horns Rev offshore wind farm. Annual report 2004.

Energy Technology Data Exchange (ETDEWEB)

Hvidt, C.B.; Bruenner, L.; Reier Knudsen, F.

2005-05-15

Elsam Engineering AS has approved the implementation of a project concerning the registration of fish communities in Horns Rev Offshore Wind Farm with use of hydroacoustic methods. In a joint effort, Bio/consult as, Carl Bro as and SIMRAD AS have monitored the fish communities at Horns Rev Offshore Wind Farm using a new hydroacoustic methodology. The new hydroacoustic technique combines the use of scientific sonar acoustics with GPS to determine the density, diversity and location of fish. The objectives of this project were to test the possibility of using hydroacoustic techniques as alternative methods to traditional techniques to assess the fish assemblage inhabiting offshore wind farms and to investigate the possible effect from the wind farm and hard bottom substrates (turbine foundations) on fish abundance. The field study was carried out October 9-10, 2004 and consisted of four horizontal hydroacoustic survey transects each covering impact and reference areas. Transects were surveyed in order to achieve identical impact and reference transect pairs concerning environment, topography and time correspondence. The hydroacoustic equipment consisted of a SIMRAD EK60/EY60 echo sounder with a split-beam transducer (Simrad ES 120-4x10) mounted on a pan and tilt unit, a transceiver, a laptop extended with a GPS-receiver and additional large external hard discs. The raw data files from EK60 were converted to echogram files suitable for the post processing application, Sonar5-Pro. The Sonar5-Pro software makes it possible to filter out echo detections from the surface and the bottom, as well as perform cross filter detection. The validity of the results using the hydroacoustic method is high due to the cross filtering and single target tracking technique. From the hydroacoustic results, no or very little effect from the wind farm or from hard bottom substrates was found on the fish densities at Horns Rev Wind Farm at the time of the survey. The execution of the field

OPERATIONAL CIRCULAR No. 4 (REV. 1) – USE OF VEHICLES BELONGING TO OR RENTED BY CERN

CERN Document Server

2012-01-01

Operational Circular No. 4 (Rev. 1) entitled “Use of vehicles belonging to or rented by CERN”, approved by the Director-general following discussion in the Standing Concertation Committee meeting of 15 February 2012, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 4 entitled “Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN” of April 2003. This new version enables, in particular, to include CERN contractors and their personnel, to harmonize the structure of the circular with other circulars and to simplify the procedures by permitting electronics forms. Department Head Office HR Department

Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

International Nuclear Information System (INIS)

2005-07-01

In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-07-15

In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

Amchitka Mud Pit Sites 2006 Post-Closure Monitoring and Inspection Report, Amchitka Island, Alaska, Rev. No.: 0

Energy Technology Data Exchange (ETDEWEB)

Matthews, Patrick

2006-09-01

In 2001, the U.S. Department of Energy (DOE), National Nuclear Security Administration (NNSA/NSO) remediated six areas associated with Amchitka mud pit release sites located on Amchitka Island, Alaska. This included the construction of seven closure caps. To ensure the integrity and effectiveness of remedial action, the mud pit sites are to be inspected every five years as part of DOE's long-term monitoring and surveillance program. In August of 2006, the closure caps were inspected in accordance with the ''Post-Closure Monitoring and Inspection Plan for Amchitka Island Mud Pit Release Sites'' (Rev. 0, November 2005). This post-closure monitoring report provides the 2006 cap inspection results.

Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005); Analisis de la situacion de la independencia fisica de los equipos y circuitos electricos de seguridad de C. N. Almaraz respecto a la R. G. 1.75 rev 3 (2005)

Energy Technology Data Exchange (ETDEWEB)

Seijas Portela, S.

2010-07-01

Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

Horns Rev offshore wind power farm. Environmental impact assessment on water quality

International Nuclear Information System (INIS)

Andersen, Per

2000-05-01

As part of an overall Environmental Impact Assessment (EIA) undertaken in connection with a planned 150 MW offshore wind farm at Horns Rev, an assessment was made of the effects the wind farm would have on the water quality in the area. This EIA study was drawn up in accordance with the guidelines laid down by the Danish Ministry of Environment and Energy in the publication 'Guidelines for the preparation of EIA studies for offshore wind farms'. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. Only local and minor changes are anticipated in connection with the currents, sediments and wave conditions during the production phase. These will occur in the immediate vicinity of the individual foundations. For these reasons, no changes are expected in the water quality. This also includes also the pelagic primary production and the occurrence of plankton in the area. Increased local copper contamination of phytoplankton and zooplankton may be expected during the production phase, as a result of the total annual discharge of 206 kg copper from the slip-rings in the wind turbines. The contamination will potentially result in a local reduction of the pelagic primary production and changes in the species composition of the plankton. The wind turbines will be sandblasted and painted once during their lifetime, as part of the routine maintenance. The sandblasting and painting will lead to a temporary spill of paint, paint waste and sand. The impacts on water quality and plankton production are unknown. It is recommended that factors such as the toxicity of the paint be investigated, and that spills and the impact of waste be reduced as much as possible. The water quality and the plankton in the wind farm area and along the cable line's passage to shore through the international protected area, will only be affected in a minor way

Evaluación de dos bombas hidráulicas de engranajes de desplazamientos 32 y 50 cm3/rev

OpenAIRE

Pedro Paneque Rondón; Eugenio Romantchik Kriuskova; Luciano Pérez Sobrevilla; Remigio Durán Hernández; Ricardo Castillo Calderín

2013-01-01

Como parte de las investigaciones que se llevan a cabo en la Universidad Agraria de La Habana (UNAH), en el Centro de Mecanización Agro- pecuaria (CEMA), con la cooperación de la Universidad Autónoma Chapingo (UACh), en el Departamento de Ingeniería Mecánica Agrícola (DIMA), dirigidas al desarrollo de la Oleohidráulica, se sometieron a evaluación dos bombas de engranajes de la marca Caproni de fabricación búlgara, con desplazamientos o cilindradas de 32 y 50 cm3/rev, refiriéndose la prueba a ...

Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors.

Science.gov (United States)

López-Lastra, M; Gabus, C; Darlix, J L

1997-11-01

The murine leukemia virus (MLV)-related type C viruses constitute a major class of retroviruses that includes numerous endogenous and exogenous mammalian viruses and the related avian spleen necrosis virus (SNV). The MLV-related viruses possess a long and multifunctional 5' untranslated leader involved in key steps of the viral life cycle--splicing, translation, RNA dimerization, encapsidation, and reverse transcription. Recent studies have shown that the 5' leader of Friend murine leukemia virus and Moloney murine leukemia virus can direct cap independent translation of gag precursor proteins (Berlioz et al., 1995; Vagner et al., 1995b). These data, together with structural homology studies (Koning et al., 1992), prompted us to undertake a search for new internal ribosome entry segment (IRES) of retroviral origin. Here we describe an IRES element within the 5' leader of avian reticuloendotheliosis virus type A (REV-A) genomic RNA. Data show that the REV-A 5' IRES element maps downstream of the packaging/dimerization (E/DLS) sequence (Watanabe and Temin, 1982; Darlix et al., 1992) and the minimal IRES sequence appears to be within a 129 nt fragment (nucleotides 452-580) of the 5' leader, immediately upstream of the gag AUG codon. The REV-A IRES has been successfully utilized in the construction of novel high titer MLV-based retroviral vectors, containing one or more IRES elements of retroviral origin. These retroviral constructs, which represent a starting point for the design of novel vectors suitable for gene therapy, are also of interest as a model system of internal translation initiation and its possible regulation during development, cancer, or virus infection.

Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

International Nuclear Information System (INIS)

2000-05-01

This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licencee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

International Nuclear Information System (INIS)

2002-05-01

This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

ποταμοφόρητος (Rev 12 : 15 – from Etymology to Theologoumenon

Directory of Open Access Journals (Sweden)

Wiesław Alicki

2013-06-01

Full Text Available The paper presents a study on translations of a Greek word ποταμοφόρητος occurring in Rev 12 : 15. The Greek hapax legomenon ποταμοφόρητος is used in Rev 12 : 15. The part of the sentence containing ποταμοφόρητος is translated as: to sweep her away with the current. G. Schneider suggests a correction of the meaning of the word, concentrating on the conjectural purpose of being taken by water (drowning. In order to analyse this issue we begin with the study of etymology of the ποταμοφόρητος. It comes from the noun ποταμός and the adjective φορητός, which is a derivative of φορέω. Composita (compounds formed with φορητός did not refer to any idea of a mortal threat. Till the turn of 19th century ποταμοφόρητος, apart from the Bible, was only certified in the Hesychius’ Lexicon (5th or 6th century. The Egyptian papyri, uncovered and analysed on the turn of the 19th and the 20th century, in which the ποταμοφόρητος is related to the overflows of the Nile, let us doubt Schneider’s proposal, however, still do not solve the problem. The next stage of the research consisted of the analysis of the classical and antique translations of Rev (VL, Vg, Syriac and Coptic translations, as well as Latin and Greek patristic commentaries, which support one of the aforementioned interpretations. The commentators understood the river carrying the Woman as the image of Church persecution and a desire to place the Church under the command of evil forces. One of the versions of the translation of Vetus Latina (type I suggests that the archetype of the water torrent in Rev was the Nile. In the light of classical explanations as to the reasons of the river’s floodings, as well as the parallel in Ezek 29 : 3. 6 we can assume that it was the Nile that served as the archetype of the spewing torrent for the author of the Revelation.

Introduction Of Wavestar Wave Energy Converters At The Danish Offshore Wind Power Plant Horns Rev 2

DEFF Research Database (Denmark)

Marquis, L.; Kramer, Morten; Kringelum, J.

is to be connected to a wind turbine at the DONG Energy owned wind power plant Horns Rev 2 placed off the western coast of Denmark. The plant delivers its energy production to a transformer station owned by Energinet.dk. Energinet.dk has the obligation to ensure that power is transmitted to the Danish consumers...... with this combination. This can increase the value of the produced power from future wind/wave plants. Further potential synergies of combining wind and wave energy in the same area include increased energy production from the available area and sharing of infrastructure costs as well as O&M facilities. In a future....... If Executed the project will be the first one in the world where wind and wave power are combined at full scale. The goal of the project is to evaluate the opportunities of combining wind and wave energy production on a commercial scale and to demonstrate the reduction of energy fluctuations...

Model-based investigation of the circadian clock and cell cycle coupling in mouse embryonic fibroblasts: Prediction of RevErb-α up-regulation during mitosis.

Science.gov (United States)

Traynard, Pauline; Feillet, Céline; Soliman, Sylvain; Delaunay, Franck; Fages, François

2016-11-01

Experimental observations have put in evidence autonomous self-sustained circadian oscillators in most mammalian cells, and proved the existence of molecular links between the circadian clock and the cell cycle. Some mathematical models have also been built to assess conditions of control of the cell cycle by the circadian clock. However, recent studies in individual NIH3T3 fibroblasts have shown an unexpected acceleration of the circadian clock together with the cell cycle when the culture medium is enriched with growth factors, and the absence of such acceleration in confluent cells. In order to explain these observations, we study a possible entrainment of the circadian clock by the cell cycle through a regulation of clock genes around the mitosis phase. We develop a computational model and a formal specification of the observed behavior to investigate the conditions of entrainment in period and phase. We show that either the selective activation of RevErb-α or the selective inhibition of Bmal1 transcription during the mitosis phase, allow us to fit the experimental data on both period and phase, while a uniform inhibition of transcription during mitosis seems incompatible with the phase data. We conclude on the arguments favoring the RevErb-α up-regulation hypothesis and on some further predictions of the model. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity

Energy Technology Data Exchange (ETDEWEB)

Fader, Kelly A.; Nault, Rance [Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Kirby, Mathew P.; Markous, Gena [Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Matthews, Jason [Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo 0316 (Norway); Zacharewski, Timothy R., E-mail: tzachare@msu.edu [Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States)

2017-04-15

Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production. To further characterize the role of Fe in AhR-mediated hepatotoxicity, male C57BL/6 mice were orally gavaged with sesame oil vehicle or 0.01–30 μg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) every 4 days for 28 days. Duodenal epithelial and hepatic RNA-Seq data were integrated with hepatic AhR ChIP-Seq, capillary electrophoresis protein measurements, and clinical chemistry analyses. TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine. Total hepatic Fe levels were negligibly increased while transferrin saturation remained unchanged. Furthermore, TCDD elicited dose-dependent gene expression changes in heme biosynthesis including the induction of aminolevulinic acid synthase 1 (Alas1) and repression of uroporphyrinogen decarboxylase (Urod), leading to a 50% increase in hepatic hemin and a 13.2-fold increase in total urinary porphyrins. Consistent with this heme accumulation, differential gene expression suggests that heme activated BACH1 and REV-ERBα/β, causing induction of heme oxygenase 1 (Hmox1) and repression of fatty acid biosynthesis, respectively. Collectively, these results suggest that Hamp repression, Fe accumulation, and increased heme levels converge to promote oxidative stress and the progression of TCDD-elicited hepatotoxicity. - Highlights: • TCDD represses hepatic hepcidin expression, leading to systemic iron overloading. • Dysregulation of heme biosynthesis is consistent with heme and porphyrin accumulation. • Heme-activated REV-ERBα/β repress circadian-regulated hepatic lipid metabolism. • Disruption of iron

Comment on “Diffusion of n-type dopants in germanium” [Appl. Phys. Rev. 1, 011301 (2014)

International Nuclear Information System (INIS)

Cowern, N. E. B.; Simdyankin, S.; Goss, J. P.; Napolitani, E.; De Salvador, D.; Bruno, E.; Mirabella, S.; Ahn, C.; Bennett, N. S.

2015-01-01

The authors of the above paper call into question recent evidence on the properties of self-interstitials, I, in Ge [Cowern et al., Phys. Rev. Lett. 110, 155501 (2013)]. We show that this judgment stems from invalid model assumptions during analysis of data on B marker-layer diffusion during proton irradiation, and that a corrected analysis fully supports the reported evidence. As previously stated, I-mediated self-diffusion in Ge exhibits two distinct regimes of temperature, T: high-T, dominated by amorphous-like mono-interstitial clusters—i-morphs—with self-diffusion entropy ≈30 k, and low-T, where transport is dominated by simple self-interstitials. In a transitional range centered on 475 °C both mechanisms contribute. The experimental I migration energy of 1.84 ± 0.26 eV reported by the Münster group based on measurements of self-diffusion during irradiation at 550 °C < T < 680 °C further establishes our proposed i-morph mechanism

Estimation of turbulence intensity using rotor effective wind speed in Lillgrund and Horns Rev-I offshore wind farms

DEFF Research Database (Denmark)

Gögmen, Tuhfe; Giebel, Gregor

2016-01-01

varies over the extent of the wind farm. This paper describes a method to estimate the TI at individual turbine locations by using the rotor effective wind speed calculated via high frequency turbine data. The method is applied to Lillgrund and Horns Rev-I offshore wind farms and the results are compared...... with TI derived from the meteorological mast, nacelle mounted anemometer on the turbines and estimation based on the standard deviation of power. The results show that the proposed TI estimation method is in the best agreement with the meteorological mast. Therefore, the rotor effective wind speed...... is shown to be applicable for the TI assessment in real-time wind farm calculations under different operational conditions. Furthermore, the TI in the wake is seen to follow the same trend with the estimated wake deficit which enables to quantify the turbulence in terms of the wake loss locally inside...

Dosimetric characterization of model Cs-1 Rev2 cesium-131 brachytherapy source in water phantoms and human tissues with MCNP5 Monte Carlo simulation

International Nuclear Information System (INIS)

Wang Jianhua; Zhang Hualin

2008-01-01

A recently developed alternative brachytherapy seed, Cs-1 Rev2 cesium-131, has begun to be used in clinical practice. The dosimetric characteristics of this source in various media, particularly in human tissues, have not been fully evaluated. The aim of this study was to calculate the dosimetric parameters for the Cs-1 Rev2 cesium-131 seed following the recommendations of the AAPM TG-43U1 report [Rivard et al., Med. Phys. 31, 633-674 (2004)] for new sources in brachytherapy applications. Dose rate constants, radial dose functions, and anisotropy functions of the source in water, Virtual Water, and relevant human soft tissues were calculated using MCNP5 Monte Carlo simulations following the TG-43U1 formalism. The results yielded dose rate constants of 1.048, 1.024, 1.041, and 1.044 cGy h -1 U -1 in water, Virtual Water, muscle, and prostate tissue, respectively. The conversion factor for this new source between water and Virtual Water was 1.02, between muscle and water was 1.006, and between prostate and water was 1.004. The authors' calculation of anisotropy functions in a Virtual Water phantom agreed closely with Murphy's measurements [Murphy et al., Med. Phys. 31, 1529-1538 (2004)]. Our calculations of the radial dose function in water and Virtual Water have good agreement with those in previous experimental and Monte Carlo studies. The TG-43U1 parameters for clinical applications in water, muscle, and prostate tissue are presented in this work

Translesion Synthesis of the N2-2′-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1

Science.gov (United States)

2016-01-01

Translesion synthesis (TLS) of the N2-2′-deoxyguanosine (dG-N2-IQ) adduct of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was investigated in human embryonic kidney 293T cells by replicating plasmid constructs in which the adduct was individually placed at each guanine (G1, G2, or G3) of the NarI sequence (5′-CG1G2CG3CC-3′). TLS efficiency was 38%, 29%, and 25% for the dG-N2-IQ located at G1, G2, and G3, respectively, which suggests that dG-N2-IQ is bypassed more efficiently by one or more DNA polymerases at G1 than at either G2 or G3. TLS efficiency was decreased 8–35% in cells with knockdown of pol η, pol κ, pol ι, pol ζ, or Rev1. Up to 75% reduction in TLS occurred when pol η, pol ζ, and Rev1 were simultaneously knocked down, suggesting that these three polymerases play important roles in dG-N2-IQ bypass. Mutation frequencies (MFs) of dG-N2-IQ at G1, G2, and G3 were 23%, 17%, and 11%, respectively, exhibiting a completely reverse trend of the previously reported MF of the C8-dG adduct of IQ (dG-C8-IQ), which is most mutagenic at G3 ((2015) Nucleic Acids Res.43, 8340−835126220181). The major type of mutation induced by dG-N2-IQ was targeted G → T, as was reported for dG-C8-IQ. In each site, knockdown of pol κ resulted in an increase in MF, whereas MF was reduced when pol η, pol ι, pol ζ, or Rev1 was knocked down. The reduction in MF was most pronounced when pol η, pol ζ, and Rev1 were simultaneously knocked down and especially when the adduct was located at G3, where MF was reduced by 90%. We conclude that pol κ predominantly performs error-free TLS of the dG-N2-IQ adduct, whereas pols η, pol ζ, and Rev1 cooperatively carry out the error-prone TLS. However, in vitro experiments using yeast pol ζ and κ showed that the former was inefficient in full-length primer extension on dG-N2-IQ templates, whereas the latter was efficient in both error-free and error-prone extensions. We believe that the observed differences between

Numerical modelling of the flow in the resin infusion process on the REV scale: A feasibility study

Energy Technology Data Exchange (ETDEWEB)

Jabbari, M.; Spangenberg, J.; Hattel, J. H. [Process Modelling Group, Department of Mechanical Engineering, Technical University of Denmark, Nils Koppels Allé, 2800 Kgs. Lyngby (Denmark); Jambhekar, V. A.; Helmig, R. [Department of Hydromechanics and Modelling of Hydrosystems, Institute for Modelling Hydraulic and Environmental Systems, Universität Stuttgart, Stuttgart (Germany); Gersborg, A. R. [SCION DTU, Diplomvej 373N, DK-2800 Lyngby (Denmark)

2016-06-08

The resin infusion process (RIP) has developed as a low cost method for manufacturing large fibre reinforced plastic parts. However, the process still presents some challenges to industry with regards to reliability and repeatability, resulting in expensive and inefficient trial and error development. In this paper, we show the implementation of 2D numerical models for the RIP using the open source simulator DuMu{sup X}. The idea of this study is to present a model which accounts for the interfacial forces coming from the capillary pressure on the so-called representative elementary volume (REV) scale. The model is described in detail and three different test cases — a constant and a tensorial permeability as well as a preform/Balsa domain — are investigated. The results show that the developed model is very applicable for the RIP for manufacturing of composite parts. The idea behind this study is to test the developed model for later use in a real application, in which the preform medium has numerous layers with different material properties.

Bird numbers and distribution in the Horns Rev offshore wind farm area. Annual status report 2003

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

This report presents data from six aerial surveys of birds in the Horns Rev wind farm area in 2003. Including 16 surveys conducted before construction of the wind farm started and three during the construction phase, a total of 25 surveys have been performed in the area since August 1999. Up until August 2002 the study area was surveyed from 26 north-south oriented, parallel transect lines. After that time four short transects were added eastwards from the previously easternmost transect. From August 2002 slight adjustments to the transect lines in the wind farm area had to be made in order to avoid collision, as survey altitude was 76 m and wind turbines are 110 m to highest wing tip. The six surveys in 2003 were performed on 13 February, 16 March, 23 April, 5 September, 4 and 30 December. The operational phase of the wind farm commenced in 2002. Hence the six surveys from 2003 are all considered post-construction data sets. A preliminary evaluation of the potential impact of the wind turbines on bird distributions has been carried out by comparison of these data to those from the 16 pre-construction surveys. (au)

Sociological investigation of the reception of Horns Rev and Nysted offshore wind farms in the local communities[Denmark

Energy Technology Data Exchange (ETDEWEB)

Kuehn, S.

2005-03-15

This annual report presents the work related to the sociological part of the socio-economic project on the local communities' reception of the Horns Rev Offshore Wind Farm, west of Blaavands Huk in Jutland, and the Nysted Offshore Wind Farm, south of Lolland. The project is part of the monitoring programme in connection with the construction of the offshore wind farms. Unlike projects, which examine the impact of the wind farms on nature, the socio-economic project did not start until 2003. The socio-economic project examines the effects on the local communities. Among other things the environmental-economic part of the project examines the preferences of the population in relation to location of the wind farm and the willingness to pay for increasing the distance between the wind farms and the coast. The sociological survey is qualitative. The survey is divided into three phases, as the aim is to investigate the public community's attitude towards the erection of an offshore wind farm before and after the construction of the wind farm. This aim is based on the assumption that attitudes may change once the wind farm is erected and the population has experienced the visibility of the wind farm, etc. The division into phases is as follows: 1) Phase 1 treats the conditions as they were before the erection of Nysted Offshore Wind Farm. 2) Phase 2 is an investigation of the development in attitudes towards Horns Rev Offshore Wind Farm a year after erection. 3) Phase 3 comprises a follow-up investigation of the local area at Nysted Offshore Wind Farm. This annual report treats phases 1 and 2. Phase 1 was carried out in April-August 2003, and the interviews at Nysted were thus made during the erection of the first offshore wind turbines. Phase 2 was carried out in September-November 2003. The follow-up investigation of the conditions in the local area around Nysted offshore wind farm is to be carried out in August-December 2004. The results of the investigations

Mr Huidong LI Deputy Chairman and Secretary-General, Rev. Committee of Chinese Nationalist Party Vice President, Sun Yat-Sen Culture Interchange Association of China Member, Committee for Internal and Judicial Affairs of the National People's Congress of China

CERN Multimedia

Bennett, Sophia Elizabeth

2017-01-01

Mr Huidong LI Deputy Chairman and Secretary-General, Rev. Committee of Chinese Nationalist Party Vice President, Sun Yat-Sen Culture Interchange Association of China Member, Committee for Internal and Judicial Affairs of the National People's Congress of China

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 304, Revision 1 (FGE.304Rev1): Four carboxamides from Chemical Groups 30

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate four flavouring substances in the Flavouring Group Evaluation 304, Revision 1 (FGE.304Rev1) using the Procedure in Commission Regulation (EC) No 1565...... criteria and identity for the materials of commerce have been provided for all four candidate substances....

A comprehensive experiment for molecular biology: Determination of single nucleotide polymorphism in human REV3 gene using PCR-RFLP.

Science.gov (United States)

Zhang, Xu; Shao, Meng; Gao, Lu; Zhao, Yuanyuan; Sun, Zixuan; Zhou, Liping; Yan, Yongmin; Shao, Qixiang; Xu, Wenrong; Qian, Hui

2017-07-08

Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of DNA polymerase ζ and SNPs in this gene are associated with altered susceptibility to cancer. This newly designed experiment is composed of three parts, including genomic DNA extraction, gene amplification by PCR, and genotyping by RFLP. By combining these activities, the students are not only able to learn a series of biotechniques in molecular biology, but also acquire the ability to link the learned knowledge with practical applications. This comprehensive experiment will help the medical students improve the conceptual understanding of SNP and the technical understanding of SNP detection. © 2017 by The International Union of Biochemistry and Molecular Biology, 45(4):299-304, 2017. © 2017 The International Union of Biochemistry and Molecular Biology.

HRensembleHR. High resolution ensemble for Horns Rev. Final project report; Offshore wind power

Energy Technology Data Exchange (ETDEWEB)

2010-03-15

The wind farm output of an offshore-farm such as Horns Rev changes between nearly constant output to highly variable power output. A balance responsible will therefore benefit from knowing the variability of a wind farm in advance. Some understanding of the observed variability and the corresponding forecast error on offshore wind farms had been gathered in the past few years, while a large fraction (about 60%) of the error still lacked understanding and required further intense research. This was the outset at the beginning of the HREnsemble project. Results from the wave study, variability study, ocean coupling, findings from the sensitivity experiments, the iEnKF short-term forecast and finally the demonstration phase have given significant synergy. The most basic research result in the project is that the two empirical mode decomposition approaches, Hilbert-Huang and later the Ensemble Empirical Mode Decomposition (EEMD). Both approaches confirmed that significant variability exists in offshore conditions. It was found that the variability of the short time-scales (24 minutes) are either not explicitly visible in the grid-scale of the NWP models or in the best case significantly smoothed out in all of the tested model configurations. If we interpret 2/3 of the variability due to vertical waves not present in the mean flow and 1/3 of the variability due to meso-scale weather, then the model results and EEMD are consistent. We can however not verify this theory. At present we do not know if EEMD counts neither the events correct nor whether the ensemble forecast suppresses variability. The existence of variability above the time-scale related to friction between ocean waves and air can in fact explain some of the inconsistent results published in the literature and set a question mark behind the correctness of the calculation of friction in wave, ocean and weather modelling. (LN)

Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Data report 2001

International Nuclear Information System (INIS)

Leonhard, S.B.; Pedersen, John

2002-08-01

The Ministry of Environment and Energy requested ELSAM and ELTRA to establish an offshore wind farm with an output of 150 MW in the waters of Horns Rev, approximately 15 km off Blaevandshuk, which is the most westerly point of Denmark. The first phase of construction of the wind farm have started in spring 2002. Before the construction activities take place, a baseline description of the benthos has been conducted as a part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines for offshore wind farms prepared by the Danish Energy Agency. The monitoring programme established for the benthic infauna was performed in spring 2001. In addition to a proposed fish investigation programme concerning the stomach contents of fish a comparative programme on benthos was established as part of the monitoring programme. The benthos sampling in connection with the fish programme was conducted in autumn 2001. This benthic survey includes sampling in a proposed reference area for the fish surveys north east of the wind farm. This report presents the data of the baseline environmental survey of the seabed in the wind farm site and in the proposed reference site and a brief description of the weather conditions at the time of sampling. (au)

PERCEPTIONS OF ORGANIZATIONAL JUSTICE WHICH TEACHERS EMPLOYED IN PRIVATE TEACHING CENTER ÖZEL DERSHANELERDE GÖREV YAPAN ÖĞRETMENLERİN ÖRGÜTSEL ADALET ALGILARI

Directory of Open Access Journals (Sweden)

Mustafa YAVUZ

2012-06-01

Full Text Available The purpose of this study is to determine the variables that predict perceptions of organizational justice which teachers employed in private teaching center (private institutions preparing students for university entrance examinations have and identify the relationship between perceptions of organizational justice which employees have and their demographic characteristics. The study is of general survey model. The population of the study consists of teachers employed in private teaching center in the Central Anatolia Region in 2008-2009 academic year. The study sample, on the other hand, includes 404 randomly selected teachers who are employed in private teaching center in the provinces of Ankara, Konya, Aksaray, Kayseri and Nevşehir. The research findingsindicate that variables of social security and job security are predictors of employees’ perceptions of organizational justice. Bu araştırmanın amacı, özel dershanelerde görev yapan öğretmenlerin örgütsel adalet algılamalarını yordayan değişkenlerin tespit edilmesi ve çalışanların örgütsel adalet algılamaları ile demografik özellikleri arasındaki ilişkiyi belirlemektir. Araştırma genel tarama modelindedir. Araştırmanın evrenini İç Anadolu bölgesindeki dershanelerde çalışan öğretmenler oluşturmaktadır. Araştırmanın örneklemi ise; tesadüfi örnekleme yöntemiyle seçilen Ankara, Konya, Aksaray, Kayseri ve Nevşehir illerindeki dershanelerde görev yapan 404 öğretmenden oluşmaktadır. Araştırmanın bulguları, sosyal güvenlik ve iş güvencesi değişkenlerinin çalışanların örgütsel adalet algılamalarının yordayıcısı olduğunu göstermektedir.

Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum.

Directory of Open Access Journals (Sweden)

Xiao-Yin Zhang

2009-09-01

Full Text Available Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents. These agents form highly toxic DNA crosslinks that cause extensive DNA damage. However, little is known about how Dictyostelium and the other "extremophiles" can tolerate and repair such large numbers of DNA crosslinks. Here we describe a comprehensive genetic analysis of crosslink repair in Dictyostelium discoideum. We analyse three gene groups that are crucial for a replication-coupled repair process that removes DNA crosslinks in higher eukarya: The Fanconi anaemia pathway (FA, translesion synthesis (TLS, and nucleotide excision repair. Gene disruption studies unexpectedly reveal that the FA genes and the TLS enzyme Rev3 play minor roles in tolerance to crosslinks in Dictyostelium. However, disruption of the Xpf nuclease subcomponent results in striking hypersensitivity to crosslinks. Genetic interaction studies reveal that although Xpf functions with FA and TLS gene products, most Xpf mediated repair is independent of these two gene groups. These results suggest that Dictyostelium utilises a distinct Xpf nuclease-mediated repair process to remove crosslinked DNA. Other DNA damage-resistant organisms and chemoresistant cancer cells might adopt a similar strategy to develop resistance to DNA crosslinking agents.

Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

International Nuclear Information System (INIS)

Leonhard, S.B.; Pedersen, John

2002-08-01

A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S B; Pedersen, John

2002-08-15

A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

Energy Technology Data Exchange (ETDEWEB)

Leonhard, S.B.; Pedersen, John

2002-08-15

A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

Pixar y la recepción de sus valores morales en el público infantil : aproximación a la investigación de la audiencia a partir del caso "Del revés"

OpenAIRE

Gutiérrez Cardona, Sònia

2016-01-01

Aquest treball té l'objectiu d'analitzar la validesa educativa del plantejament de la filmografia de Pixar. El projecte també pretén esbrinar si aquest rigor educatiu s'adapta als espectadors infantils de Pixar. L'objecte d'estudi de la investigació és la recepció de valors en les pel·lícules de la productora cinematogràfica a partir del cas "Del revés". L'anàlisi de valors s'ha realitzat a una mostra de públic infantil de 45 subjectes, aplicant un Test de presència de valors, ideat i creat p...

Revival and emended description of 'Mycobacterium paraffinicum' Davis, Chase and Raymond 1956 as Mycobacterium paraffinicum sp. nov., nom. rev.

Science.gov (United States)

Toney, Nadege; Adekambi, Toidi; Toney, Sean; Yakrus, Mitchell; Butler, W Ray

2010-10-01

The omission of the name 'Mycobacterium paraffinicum' from the Approved Lists of Bacterial Names was due to phenotypic confusion surrounding a close relationship with Mycobacterium scrofulaceum. Correspondingly, 'M. paraffinicum' strains grew slowly in > 7 days, stained acid-alcohol-fast and produced yellow-pigmented, smooth, waxy colonies in the dark at an optimal temperature of 35°C. However, 'M. paraffinicum' strains demonstrated no activity for urease, nicotinamidase or pyrazinamidase and lacked growth at 42°C, unlike M. scrofulaceum. The mycolic acid pattern, as determined by HPLC, clustered 'M. paraffinicum' with M. scrofulaceum, Mycobacterium avium and Mycobacterium parascrofulaceum. Strains were fully susceptible to linezolid, rifabutin, clarithromycin and amikacin. Examination of the historical reference strain of 'M. paraffinicum', ATCC 12670, and five additional isolates using comparative studies with 16S rRNA, hsp65 and rpoB gene and concatenated sequences showed that they formed a tight taxonomic group that was distinct from similar non-tuberculous mycobacteria. Multilocus enzyme electrophoresis (MEE) analysis confirmed a close association of the five additional isolates with the reference strain of 'M. paraffinicum' with a genetic distance of 0.12 and showed that all six strains were distinct from other closely related species. These genetic results provided unambiguous evidence of the uniqueness of this slowly growing, scotochromogenic species and supported the revival of the name as Mycobacterium paraffinicum (ex Davis, Chase and Raymond 1956) sp. nov., nom. rev. We propose the previously deposited reference strain ATCC 12670(T) =DSM 44181(T) =NCIMB 10420(T), located in collections worldwide, as the type strain.

The uvsI gene of Aspergillus nidulans required for UV-mutagenesis encodes a homolog to REV3, a subunit of the DNA polymerase zeta of yeast involved in translesion DNA synthesis.

Science.gov (United States)

Han, K Y; Chae, S K; Han, D M

1998-07-01

Defects in the uvsI gene of Aspergillus nidulans resulted in high UV sensitivity and reductions of spontaneous and UV-induced reversion of certain alleles, uvsl;uvsA double mutants exhibited high methyl methane sulfonate (MMS)-sensitivity in contrast to the slight sensitivity of the component single mutants. Using such a double mutant as recipient, a clone complementing uvsI501 has been isolated from a chromosome III specific library. The deduced amino acid sequence from the 1.1-kb sequenced region, a part of the 5.2-kb DNA fragment showing uvsI-complementing activity, had a 62% identity with REV3 of yeast. Disruptants of the cloned gene demonstrated the same level of sensitivity to UV light as uvsI and failed to complement uvsI501 in heterozygous diploids.

A Study on Improvement of Test Method of Nuclear Power Plant ESF ACS by applying Regulatory Guide 1.52 (Rev.3)

International Nuclear Information System (INIS)

Lee, Sook Kyung; Kim, Kwang Sin; Sohn, Soon Hwan; Song, Kyu Min; Lee, Kae Woo; Cho, Byoung Ho; Park, Jeong Seo; Yoo, Byeang Jea; Hong, Soon Joon; Kang, Sun Haeng

2010-01-01

U. S. NRC Regulation Guide 1.52 regulating ESF ACS in nuclear power plants has been revised to revision 3. To apply reduction of operability test time, allowance of alternative challenge agents for in-place leak test of HEPA filters, and upgrade of Methyl Iodide penetration acceptance criterion in activated carbon performance test suggested in Reg. Guide 1.52(Rev.3) on Yonggwang units 5 and 6 ESF ACSes, technical feasibility study was carried out with on-site experiments as well as experiments with a lab-scale model. It was confirmed that the moisture in the system returned to the level before the test in 1 or 4 days even though the moisture was removed during the operability test lasting more than 10 hours. Therefore, it is appropriate to perform monthly operability test in 15 minutes just long enough to check the operability of equipment. To change challenge material for in-place HEPA filter leak test, size of aerosol, production rate, and leak detection capability were compared for DOP and PAO. It was concluded that PAO can be substituted for DOP in nuclear power plants. The upgrade of Methyl Iodide penetration acceptance criterion from 0.175 % to 0.5 % in active carbon filter bed deeper than 4 inches was to conform to the change of activated carbon performance test method to ASTM D3803(1989). It was confirmed that Methyl Iodide penetration acceptance criterion of 0.5 % under 30 .deg. C

Reclassification of Flexibacter tractuosus (Lewin 1969) Leadbetter 1974 and 'Microscilla sericea' Lewin 1969 in the genus Marivirga gen. nov. as Marivirga tractuosa comb. nov. and Marivirga sericea nom. rev., comb. nov.

Science.gov (United States)

Nedashkovskaya, Olga I; Vancanneyt, Marc; Kim, Seung Bum; Bae, Kyung Sook

2010-08-01

The taxonomic position of the misclassified strains [Flexibacter] tractuosus KCTC 2958T and '[Microscilla] sericea' LMG 13021 was studied using a polyphasic approach. The two strains shared 99.1% 16S rRNA gene sequence similarity and 28% DNA-DNA relatedness. On the basis of the phylogenetic evidence supported by genotypic and phenotypic data [Flexibacter] tractuosus KCTC 2958T and '[Microscilla] sericea' LMG 13021 are classified as two distinct species in a novel genus, Marivirga, in the family 'Flammeovirgaceae', as Marivirga tractuosa comb. nov. and Marivirga sericea nom. rev., comb. nov., with strains KCTC 2958T (=ATCC 23168T =CIP 106410T =DSM 4126T =NBRC 15989T =NCIMB 1408T =VKM B-1430T) and LMG 13021T (=ATCC 23182T =NBRC 15983T =NCIMB 1403T), respectively, as the type strains. The type species is Marivirga tractuosa.

Development of a Computer Code, PZRTR rev 1, for the Thermal Hydraulic Analysis of a Multi-Cavity Cold Gas Pressurizer for an Integral Reactor, SMART-P

Energy Technology Data Exchange (ETDEWEB)

Seo, Jae Kwang; Kang, H. O.; Yoon, J.; Kim, K. K

2006-12-15

The concept of a Multi-cavity Cold Gas PressuriZeR(MCGPZR) is applied to the SMART: The pressurizer system includes in-vessel cavities and out-of-vessel gas cylinders holding the gas supply/vent system. The gas cylinders are connected to the one of the in-vessel cavities via piping with valves. A pressurizer is maintained at a cold temperature of less than about 120 .deg. C which is realized with coolers installed in and with wet thermal insulators installed on one of the cavities located inside the hot reactor vessel, to minimize the contribution of a steam partial pressure and is filled with nitrogen gas as a pressure-absorbing medium. The working medium and working temperature of the MCGPZR is totally different from that of a hot steam pressurizer of the commercial PWR. In addition, the MCGPZR is intended to be designed to meet a pressure transient during normal power operation (by its gas volume capacity) without using an active control system and during plant heatup/cooldown operation by using an active gas control (filling/venting) system. Therefore in order to evaluate the feasibility of the concept of the MCGPZR and its intended design goal, the thermal hydraulic behaviors and controllability of the MCGPZR during transients especially a heatup/cooldown operation must be analyzed. In this study, a thermal hydraulic transient analysis computer code, PZRTR rev 1, for the Reactor Coolant System(RCS) of an integral reactor composed of the MCGPZR, modular Once-Through Steam Generators(OTSGs), a core and a reactor coolant loop is developed. The pressurizer module (MCGPZR module) of the PZRTR rev 1 code is based on a two-fluid, nonhomogeneous, nonequilibrium model for the two-phase system behavior and the OTSG module is based on a homogeneous equilibrium model of the two-phase flow process. The core module is simply based on the axial power distributions and the reactor coolant loop is based on the temperature distributions. The code is currently dedicated for the

New mutations affecting induced mutagenesis in yeast.

Science.gov (United States)

Lawrence, C W; Krauss, B R; Christensen, R B

1985-01-01

Previously isolated mutations in baker's yeast, Saccharomyces cerevisiae, that impair induced mutagenesis were all identified with the aid of tests that either exclusively or predominantly detect base-pair substitutions. To avoid this bias, we have screened 11 366 potentially mutant clones for UV-induced reversion of the frameshift allele, his4-38, and have identified 10 mutants that give much reduced yields of revertants. Complementation and recombination tests show that 6 of these carry mutations at the previously known REV1, REV1 and REV3 loci, while the remaining 4 define 3 new genes, REV4 (2 mutations), REV5 and REV6. The rev4 mutations are readily suppressed in many genetic backgrounds and, like the rev5 mutation, impart only a limited deficiency for induced mutagenesis: it is likely, therefore that the REV4+ and REV5+ gene functions are only remotely concerned with this process. The rev6 mutants have a more general deficiency, however, as well as marked sensitivity to UV and an increased spontaneous mutation rate, properties that suggest the REV6 gene is directly involved in mutation induction. The REV5 gene is located about 1 cM proximal to CYC1 on chromosome X.

Nuclear Power Plants (Rev.)

Energy Technology Data Exchange (ETDEWEB)

Lyerly, Ray L.; Mitchell III, Walter [Southern Nuclear Engineering, Inc.

1973-01-01

Projected energy requirements for the future suggest that we must employ atomic energy to generate electric power or face depletion of our fossil-fuel resources—coal, oil, and gas. In short, both conservation and economic considerations will require us to use nuclear energy to generate the electricity that supports our civilization. Until we reach the time when nuclear power plants are as common as fossil-fueled or hydroelectric plants, many people will wonder how the nuclear plants work, how much they cost, where they are located, and what kinds of reactors they use. The purpose of this booklet is to answer these questions. In doing so, it will consider only central station plants, which are those that provide electric power for established utility systems.

s |-|~o RT"? REv

African Journals Online (AJOL)

subserving any useful function)”. Tumour arising from any portion of the eyeball either on thesurface or within the eyeball constitutes an ocular neoplasm. Ocular tumours may be benign with a slow propensity to proliferation. Metastasis is rare. However, the function may be compromised due too compression of.

Electricity and Man (Rev.)

Energy Technology Data Exchange (ETDEWEB)

Asimov, Isaac

1974-01-01

Our whole industrial civilization depends upon cheap energy streaking out in all directions and under fingertip controls—and that would be very difficult without electric current. It would take enormous ingenuity to find substitutes. If all electricity were shut off, then all electronic devices would be dead. Electric lights would darken. Aluminum would become a rare metal. All factories would have to develop power sources on the spot and would have to switch to primitive, mechanical controls. Every house and every farm would have to give up items we have come to take for granted—not only electric lights, but electric irons, electric toasters, electric water pumps, electric control of furnaces, and so on.

Premixed Supersonic Combustion (Rev)

Science.gov (United States)

2015-02-20

calculated using the 1-D separated flow model for the isolator described in Heiser and Pratt (Ref. 19). Several curves are shown. The green curve corresponds...Report 88-3059, 1988. [18] Krauss, R.H. and McDaniel, J.C., “A Clean Air Continuous Flow Propulsion Facility,” AIAA Report 92-3912, 1992. [19] Heiser

Whole Body Counters (rev.)

Energy Technology Data Exchange (ETDEWEB)

Woodburn, John H. [Walter Johnson High School, Rockville, MD; Lengemann, Frederick W. [Cornell University

1967-01-01

Whole body counters are radiation detecting and measuring instruments that provide information about the human body. This booklet describes different whole body counters, scientific principles that are applied to their design, and ways they are used.

Radiotherapy. 2. rev. ed.

International Nuclear Information System (INIS)

Wannenmacher, Michael; Debus, Juergen; Wenz, Frederik

2013-01-01

The purpose of this medical specialty book, besides presenting the state of the art in clinical radiotherapy and radiooncology, is to explain the basic principles of medical physics and radiobiology. Following a number of chapters on general topics and theory it provides detailed coverage of the individual organ systems, briefly addressing future aspects in the process. The authors relate their view that radiooncology as a medical specialty will continue to be under pressure to change and that it will take continuous innovation to secure its status within the interdisciplinary context around the treatment of cancer patients. The authors of this, the textbook's second edition, have dedicated much space to modern methods and techniques in order to do justice to these developments.

Analysis of mutagenic DNA repair in a thermoconditional repair mutant of Saccharomyces cerevisiae. Pt. 2

International Nuclear Information System (INIS)

Siede, W.; Eckardt, F.; Brendel, M.

1983-01-01

The time course of REV2 dependent recovery from prelethal UV damage and UV-induced locus-specific reversion of the his5-2 allele was determined in temperature-shift experiments by use of a thermoconditional allele of the rev2 gene (rad5-8, rev2sup(ts)). In UV-irradiated, exponentially growing rev2sup(ts) cells the REV2 dependent repair acitivity persists for up to 8 h at permissive temperature (23 0 C), while the REV2 dependent mutagenic process is mostly completed within 2 h. The REV2 dependent process in exponentially growing cells is highly impaired by inhibition of protein synthesis. However, a REV2 dependent repair activity independent of de novo synthesis is detectable, even in the presence of up to 200 μg/ml cycloheximide, a response not found in stationary phase cells. Thus, the REV2 dependent process seems to be partially constitutive in exponentially growing cells. Additionally, exponentially growing rev2sup(ts) cells were considerably more UV-sensitive at restrictive temperature (36 0 C) than were stationary phase cells. (orig.)

Eddy Current Testing at Level 2: Manual for the Syllabi Contained in IAEA-TECDOC-628.Rev. 2 'Training Guidelines for Non Destructive Testing Techniques'

International Nuclear Information System (INIS)

2011-01-01

The International Atomic Energy Agency has been active in the promotion of non-destructive testing (NDT) technology in the world for many decades. The prime reason for this interest has been the need for stringent standards for quality control for safe operation of nuclear as well as other industrial installations. It has successfully executed a number of programmes including technical co-operation (TC) projects (national and regional) and the coordinated research projects (CRP) of which NDT was an important part. Through these programmes a large number of persons in the Member States have been trained, leading to establishment of national certifying bodies (NCB) responsible for training and certification of NDT personnel. Consequently, a state of self-sufficiency in this area of technology has been achieved in many of them. All along there has been a realization of the need to have well established training guidelines and related books in order, firstly, to guide the IAEA experts who were involved in this training programme and, secondly, to achieve some level of international uniformity and harmonization of training materials and consequent competence of NDT personnel. The syllabi for training courses have been published in the form of IAEA-TECDOC publications. The first was IAEA-TECDOC-407 (1987), which contained syllabi for the basic five methods, i.e. liquid penetrant testing, magnetic particle testing, eddy current testing, radiographic testing and ultrasonic testing. To accommodate advancements in NDT technology, later versions of this publication were issued in 1991, 2002 and 2008, the current version being IAEA-TECDOC-628/Rev.2 (2008), which includes additional and more advanced NDT methods. This IAEA-TECDOC, as well as most of the international standards on the subject of training and certification of NDT personnel including ISO 9712 (2005), define three levels of competence. Among these, level 1 is the lowest and level 3 the highest. The intermediate

Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2002 - 31. December 2002

International Nuclear Information System (INIS)

2003-04-01

This annual report, which is a baseline and/or an evaluation of the effects of construction phase, is based on extracts from our consultants' annual reports. These annual reports are individual reports, in which surveys have been made during the year 2002 and reported in the beginning of 2003. Detailed information on methods, programmes and conclusions can be found in these reports. In general it should be noted that apparently the construction phase has not had any unintended effects on the parameters surveyed. Therefore we can also conclude that the protective measures established by Elsam, especially scaring devices/ramp-ups for marine mammals, have had the intended effect. Especially interesting parameters that should be mentioned are: Birds: The seagull species 'Herring Gulls' was found to be attracted by the wind farm during the construction period. The number of Divers has decreased, however statistically this decrease is very small as very few Divers have been observed under the baseline. Porpoises: Porpoises generally stayed away from the construction area during pile driving. This effect was intended and scaring devices were deployed in order to ensure that the animals' hearing was not permanently damaged. Seals: The purpose of the programme has not been to show statistically significant effects during the construction phase. The purpose was to get an idea of their behaviour during the construction phase within the wind farm as well as on the reef. It has been concluded that Horns Rev is not used as a foraging area as much as expected. It is used as transit area for bigger foraging sites in the North Sea. Sand eels and Spisula: A baseline survey of sand eels within the wind farm area has been made. It is shown that sand eels are found in the wind farm area. Spisula have been found in the wind farm area but not in the amount expected. Hard substrate habitat: Baseline surveys on fish have been made during the spring of 2002. The programme regarding the

[Construction of autocatalytic caspase-3 driven by amplified human telomerase reverse transcriptase promoter and its enhanced efficacy of inducing apoptosis in human ovarian carcinoma].

Science.gov (United States)

Song, Yue; Shen, Keng; He, Chun-Xia

2007-09-01

To construct recombinant adenoviral vector expressing autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter amplified by two-step transcription amplification (hTERTp-TSTA), and investigate its antitumor effect in ovarian cancer in vitro and in vivo. Recombinant adenoviruses expressing autocatalytic caspase-3 (rev-caspase-3) driven by hTERTp-TSTA were prepared, which were named as AdHTVP2G5-rev-casp3. AdHT-rev-casp3, Ad-rev-casp3 and AdHTVP2G5-EGEP, which express rev-caspase-3 driven by hTERTp, cytomegalovirus promoter (CMVp) and enhanced green fluorescent protein (EGFP), respectively, were used as controls. Western blot, cell counting kit (CCK-8), flow cytometry (FCM) and TdT-mediated dUTP-biotin nick end labeling (TUNEL) were used to detect the expression of p17, active subunit of caspase-3, and p85, and to measure cell survival rates, apoptotic rates and cell cycle distribution in ovarian cell line AO and normal human umbilical vein endothelial cell line HUVEC, following treatments of AdHTVP2G5-rev-casp3. subcutaneous tumor models and abdominally spread tumor models of human ovarian carcinoma using AO cells in BALB/c nude mice were established. Following treatments of AdHTVP2G5-rev-casp3, western blot was used to detect the expression of active caspase-3 in abdominally spread tumors and liver tissues, respectively, and the mouse survival rates and the volume of tumor nodules were measured, and the serum level of alanine transaminase (ALT) and aspartate transaminase (AST) were analyzed to monitor liver damages and HE staining was used to detect the histopathological changes of various organs. The levels of p17 expression in AdHTVP2G5-rev-casp3-treated AO cells were significantly higher than that in Ad-rev-casp3 or AdHT-rev-casp3 treated AO cells, while no expression was observed in AdHTVP2G5-rev-casp3-treated HUVEC. There was strong cell killing of AdHTVP2G5-rev-casp3 of hTERT positive AO cells, but not of the hTERT-negative HUVEC cells

[The efficacy of autocatalytic casapse-3 driven by human telomerase reverse transcriptase promoter on human ovarian carcinoma].

Science.gov (United States)

Song, Yue; Shen, Keng; Yu, Jing-rong

2007-11-06

To construct recombinant adenoviral vector expressing autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter (hTERTp), and investigate its antitumor effect on ovarian cancer in vitro and in vivo. Recombinant adenovirus expressing autocatalytic caspase-3 (rev-csapase-3) driven by hTERTp, AdHT-rev-casp3, was constructed. Ad-rev-casp3 expressing rev-caspase-3 driven by cytomegalovirus promoter (CMVp) was used as a positive control. hTERT positive human ovarian cancer cells of the line AO and hTERT-negative human umbilical venous endothelial cells (HUVECs) were cultured and transfected with AdHT-rev-casp3, Ad-rev-casp3, or Ad-EGFG expressing enhanced green fluorescent protein as control group. Western blotting, Cell Counting Kit (CCK-8), flow cytometry, and TUNEL were used to detect the expression of p17, active subunit of caspase-3, and p85, a poly ADP-ribose polymerase (PARP) cleavage fragment, and they were also used to measure the cell survival rate and apoptotic rate. Western blotting was used to detect the expression of active caspase-3 and its substrate PARP in the AO cells and HUVECs. Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3. Another 40 mice underwent intraperitoneal injection of AO cells to establish intraperitoneal transplanted tumor models, 21 days later the rats were divided into 4 equal groups to be injected intraperitoneally with AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, or PBS, the survival rate was observed, and the blood levels of alanine transaminase

Dicty_cDB: Contig-U11651-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 0 1 ( BJ435790 ) Dictyostelium discoideum cDNA clone:ddv28j10, 3' ... 355 2e-93 1 ( EY481033 ) CBBP11161.rev CBBP Hirudo medicina...lis hermaphrodi... 36 1.6 2 ( EY486444 ) CBBP15196.rev CBBP Hirudo medicinalis hermaphr...odi... 36 1.6 2 ( EY503165 ) CBBP6773.rev CBBP Hirudo medicinalis hermaphrodit...... 36 1.6 2 ( EY494245 ) CBBP19905.rev CBBP Hirudo medicinalis hermaphrodi... 36 1.6 2 ( EY504499 ) CBBP7545.rev CBBP Hirudo medicina...lis hermaphrodit... 36 1.6 2 ( EY503685 ) CBBP7067.rev CBBP Hirudo medicinalis hermap

Vanishing Hall conductance in the phase-glass Bose metal at zero temperature

Science.gov (United States)

May-Mann, Julian; Phillips, Philip W.

2018-01-01

Motivated in part by numerical simulations [H. G. Katzgraber and A. P. Young, Phys. Rev. B 66, 224507 (2002), 10.1103/PhysRevB.66.224507; J. M. Kosterlitz and N. Akino, Phys. Rev. Lett. 81, 4672 (1998), 10.1103/PhysRevLett.81.4672; Phys. Rev. Lett. 81, 4672 (1998), 10.1103/PhysRevLett.81.4672] that reveal that the energy to create a defect in a gauge or phase glass scales as Lθ with θ power law as does the longitudinal conductance. This prediction can be verified experimentally by applying a ground plane to the 2D samples.

Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51).

Science.gov (United States)

Azimzadeh, Kaveh; Nasrollahi Nargesabad, Reza; Vousooghi, Nasim

2017-08-01

Brucellosis is known as one of important zoonosis. Studying the histological and biochemical effects of the disease could help to increase our knowledge about it. The aim of the present study was to evaluate changes of plasma parameters after intraperitoneal injection of two species of Brucella (Brucella melitensis and Brucella abortus) and two vaccines (Rev-1, RB-51) in the rat. Forty male rats were divided into five groups (n = 8 in each group). Two groups received suspensions of Brucella abortus and Brucella melitensis and two other groups were injected intraperitoneally with two mentioned vaccines and the last group received only distilled water. The results showed a significant increase in sphingosine 1-phosphate, Malondialdehyde, hepcidin, homocysteine, cardiac troponin I and copper levels and a considerable decrease in the levels of iron and zinc (P ≤ 0.01) in infected groups compared to the control animals. In vaccinated groups, hepcidin was increased but other parameters were not changed in comparison to the control group. It can be concluded that increase of homocysteine and cardiac troponin I in brucellosis could be a warning for cardiac adverse effects. Besides, increase of sphingosine 1-phosphate probably indicates its stimulant and modulatory effects in anti- Brucellosis biochemical pathways of the host. Copyright © 2017 Elsevier Ltd. All rights reserved.

Three-electron spin qubits

Science.gov (United States)

Russ, Maximilian; Burkard, Guido

2017-10-01

The goal of this article is to review the progress of three-electron spin qubits from their inception to the state of the art. We direct the main focus towards the exchange-only qubit (Bacon et al 2000 Phys. Rev. Lett. 85 1758-61, DiVincenzo et al 2000 Nature 408 339) and its derived versions, e.g. the resonant exchange (RX) qubit, but we also discuss other qubit implementations using three electron spins. For each three-spin qubit we describe the qubit model, the envisioned physical realization, the implementations of single-qubit operations, as well as the read-out and initialization schemes. Two-qubit gates and decoherence properties are discussed for the RX qubit and the exchange-only qubit, thereby completing the list of requirements for quantum computation for a viable candidate qubit implementation. We start by describing the full system of three electrons in a triple quantum dot, then discuss the charge-stability diagram, restricting ourselves to the relevant subsystem, introduce the qubit states, and discuss important transitions to other charge states (Russ et al 2016 Phys. Rev. B 94 165411). Introducing the various qubit implementations, we begin with the exchange-only qubit (DiVincenzo et al 2000 Nature 408 339, Laird et al 2010 Phys. Rev. B 82 075403), followed by the RX qubit (Medford et al 2013 Phys. Rev. Lett. 111 050501, Taylor et al 2013 Phys. Rev. Lett. 111 050502), the spin-charge qubit (Kyriakidis and Burkard 2007 Phys. Rev. B 75 115324), and the hybrid qubit (Shi et al 2012 Phys. Rev. Lett. 108 140503, Koh et al 2012 Phys. Rev. Lett. 109 250503, Cao et al 2016 Phys. Rev. Lett. 116 086801, Thorgrimsson et al 2016 arXiv:1611.04945). The main focus will be on the exchange-only qubit and its modification, the RX qubit, whose single-qubit operations are realized by driving the qubit at its resonant frequency in the microwave range similar to electron spin resonance. Two different types of two-qubit operations are presented for the exchange

Thermodynamics of quantum spacetime histories

Science.gov (United States)

Smolin, Lee

2017-11-01

We show that the simplicity constraints, which define the dynamics of spin foam models, imply, and are implied by, the first law of thermodynamics, when the latter is applied to causal diamonds in the quantum spacetime. This result reveals an intimate connection between the holographic nature of gravity, as reflected by the Bekenstein entropy, and the fact that general relativity and other gravitational theories can be understood as constrained topological field theories. To state and derive this correspondence we describe causal diamonds in the causal structure of spin foam histories and generalize arguments given for the near horizon region of black holes by Frodden, Gosh and Perez [Phys. Rev. D 87, 121503 (2013); , 10.1103/PhysRevD.87.121503Phys. Rev. D 89, 084069 (2014); , 10.1103/PhysRevD.89.084069Phys. Rev. Lett. 107, 241301 (2011); , 10.1103/PhysRevLett.107.241301Phys. Rev. Lett.108, 169901(E) (2012)., 10.1103/PhysRevLett.108.169901] and Bianchi [arXiv:1204.5122.]. This allows us to apply a recent argument of Jacobson [Phys. Rev. Lett. 116, 201101 (2016).10.1103/PhysRevLett.116.201101] to show that if a spin foam history has a semiclassical limit described in terms of a smooth metric geometry, that geometry satisfies the Einstein equations. These results suggest also a proposal for a quantum equivalence principle.

Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2002 - 31. December 2002

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-04-15

This annual report, which is a baseline and/or an evaluation of the effects of construction phase, is based on extracts from our consultants' annual reports. These annual reports are individual reports, in which surveys have been made during the year 2002 and reported in the beginning of 2003. Detailed information on methods, programmes and conclusions can be found in these reports. In general it should be noted that apparently the construction phase has not had any unintended effects on the parameters surveyed. Therefore we can also conclude that the protective measures established by Elsam, especially scaring devices/ramp-ups for marine mammals, have had the intended effect. Especially interesting parameters that should be mentioned are: Birds: The seagull species 'Herring Gulls' was found to be attracted by the wind farm during the construction period. The number of Divers has decreased, however statistically this decrease is very small as very few Divers have been observed under the baseline. Porpoises: Porpoises generally stayed away from the construction area during pile driving. This effect was intended and scaring devices were deployed in order to ensure that the animals' hearing was not permanently damaged. Seals: The purpose of the programme has not been to show statistically significant effects during the construction phase. The purpose was to get an idea of their behaviour during the construction phase within the wind farm as well as on the reef. It has been concluded that Horns Rev is not used as a foraging area as much as expected. It is used as transit area for bigger foraging sites in the North Sea. Sand eels and Spisula: A baseline survey of sand eels within the wind farm area has been made. It is shown that sand eels are found in the wind farm area. Spisula have been found in the wind farm area but not in the amount expected. Hard substrate habitat: Baseline surveys on fish have been made during the spring of 2002. The

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular......, the Panel was requested to evaluate 12 flavouring substances in the Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 12 flavouring substances belong to chemical group 10, Annex I of the Commission Regulation (EC...... is a tertiary alcohol) [FL-no: 07.097, 07.165 and 07.184] all belonging to chemical groups 8 and 10. One of the 12 candidate substances possesses four chiral centres [FL-no: 06.134] two possesses two chiral centres [FL-no: 02.133 and 07.168] and four substances possesses one chiral centre [FL-no: 07.097, 07...

Comment on ``Attractive forces between ions in quantum plasmas: Failure of linearized quantum hydrodynamics''

Science.gov (United States)

Shukla, P. K.; Eliasson, B.; Akbari-Moghanjoughi, M.

2013-03-01

In a recent paper, Bonitz, Pehlke, and Schoof [Phys. Rev. E10.1103/PhysRevE.87.033105 87, 033105 (2013)], hereafter referred to as BPS, have raised some points against the Shukla-Eliasson attractive potential [P. K. Shukla and B. Eliasson, Phys. Rev. Lett.0031-900710.1103/PhysRevLett.108.165007 108, 165007 (2012); P. K. Shukla and B. Eliasson, Phys. Rev. Lett.0031-900710.1103/PhysRevLett.108.219902 108, 219902(E) (2012); P. K. Shukla and B. Eliasson, Phys. Rev. Lett.10.1103/PhysRevLett.109.019901 109, 019901(E) (2012)], hereafter referred to as SEAP, around a stationary test charge in a quantum plasma. Our objective here is to discuss the insufficiency of the BPS reasoning concerning the applicability of the linearized quantum hydrodynamic theory, as well as to point out the shortcomings in BPS’s arguments and to suggest how to salvage BPS’s density functional theory and simulations, which have failed to produce results that correctly match with that of Shukla and Eliasson.

Relativistic Chiral Kinetic Theory

International Nuclear Information System (INIS)

Stephanov, Mikhail

2016-01-01

This very brief review of the recent progress in chiral kinetic theory is based on the results of Refs. [J.-Y. Chen, D. T. Son, M. A. Stephanov, H.-U. Yee, Y. Yin, Lorentz Invariance in Chiral Kinetic Theory, Phys. Rev. Lett. 113 (18) (2014) 182302. doi: (10.1103/PhysRevLett.113.182302); J.-Y. Chen, D. T. Son, M. A. Stephanov, Collisions in Chiral Kinetic Theory, Phys. Rev. Lett. 115 (2) (2015) 021601. doi: (10.1103/PhysRevLett.115.021601); M. A. Stephanov, H.-U. Yee, The no-drag frame for anomalous chiral fluid, Phys. Rev. Lett. 116 (12) (2016) 122302. doi: (10.1103/PhysRevLett.116.122302)].

Relativistic Chiral Kinetic Theory

Energy Technology Data Exchange (ETDEWEB)

Stephanov, Mikhail

2016-12-15

This very brief review of the recent progress in chiral kinetic theory is based on the results of Refs. [J.-Y. Chen, D. T. Son, M. A. Stephanov, H.-U. Yee, Y. Yin, Lorentz Invariance in Chiral Kinetic Theory, Phys. Rev. Lett. 113 (18) (2014) 182302. doi: (10.1103/PhysRevLett.113.182302); J.-Y. Chen, D. T. Son, M. A. Stephanov, Collisions in Chiral Kinetic Theory, Phys. Rev. Lett. 115 (2) (2015) 021601. doi: (10.1103/PhysRevLett.115.021601); M. A. Stephanov, H.-U. Yee, The no-drag frame for anomalous chiral fluid, Phys. Rev. Lett. 116 (12) (2016) 122302. doi: (10.1103/PhysRevLett.116.122302)].

The relationship between randomness and power-law distributed move lengths in random walk algorithms

Science.gov (United States)

Sakiyama, Tomoko; Gunji, Yukio-Pegio

2014-05-01

Recently, we proposed a new random walk algorithm, termed the REV algorithm, in which the agent alters the directional rule that governs it using the most recent four random numbers. Here, we examined how a non-bounded number, i.e., "randomness" regarding move direction, was important for optimal searching and power-law distributed step lengths in rule change. We proposed two algorithms: the REV and REV-bounded algorithms. In the REV algorithm, one of the four random numbers used to change the rule is non-bounded. In contrast, all four random numbers in the REV-bounded algorithm are bounded. We showed that the REV algorithm exhibited more consistent power-law distributed step lengths and flexible searching behavior.

Comparative analysis of type 1 and type 2 cassava peeling machines

African Journals Online (AJOL)

A comparative analysis of type 1 and type 2 cassava peeling machines with nail lengths of 26mm and 20mm were investigated in order to improve peeling techniques of cassava tubers. The machines were evaluated at four (4) different speeds; (80rev/min, 90rev/min, 100rev/min, and 110rev/min), with 750HP petrol engine.

The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism

Energy Technology Data Exchange (ETDEWEB)

McDonald, J. P. [NIH, Bethesda, MD. (United States); Levine, A. S.; Woodgate, R.

1997-12-15

Damage-inducible mutagenesis in prokaryotes is largely dependent upon the activity of the UmuD'C-like proteins. Since many DNA repair processes are structurally and/or functionally conserved between prokaryotes and eukaryotes, we investigated the role of RAD30, a previously uncharacterized Saccharomyces cerevisiae DNA repair gene related to the Escherichia coli dinB, umuC and S. cerevisiae REV1 genes, in UV resistance and UV-induced mutagenesis. Similar to its prokaryotic homologues, RAD30 was found to be damage inducible. Like many S. cerevisiae genes involved in error-prone DNA repair, epistasis analysis clearly places RAD30 in the RAD6 group and rad30 mutants display moderate UV sensitivity reminiscent of rev mutants. However, unlike rev mutants, no defect in UV-induced reversion was seen in rad30 strains. While rad6 and rad18 are both epistatic to rad30, no epistasis was observed with rev1, rev3, rev7 or rad5, all of which are members of the RAD6 epistasis group. These findings suggest that RD30 participates in a novel error-free repair pathway dependent on RAD6 and RAD18, but independent of REV1, REV3, REV7 and RAD5. (author)

Stable assembly of HIV-1 export complexes occurs cotranscriptionally

DEFF Research Database (Denmark)

Nawroth, Isabel; Mueller, Florian; Basyuk, Eugenia

2014-01-01

The HIV-1 Rev protein mediates export of unspliced and singly spliced viral transcripts by binding to the Rev response element (RRE) and recruiting the cellular export factor CRM1. Here, we investigated the recruitment of Rev to the transcription sites of HIV-1 reporters that splice either post......- or cotranscriptionally. In both cases, we observed that Rev localized to the transcription sites of the reporters and recruited CRM1. Rev and CRM1 remained at the reporter transcription sites when cells were treated with the splicing inhibitor Spliceostatin A (SSA), showing that the proteins associate with RNA prior...... to or during early spliceosome assembly. Fluorescence recovery after photobleaching (FRAP) revealed that Rev and CRM1 have similar kinetics as the HIV-1 RNA, indicating that Rev, CRM1, and RRE-containing RNAs are released from the site of transcription in one single export complex. These results suggest...

Administrative Circulars

CERN Document Server

Département des Ressources humaines

2004-01-01

Administrative Circular N° 2 (Rev. 2) - May 2004 Guidelines and procedures concerning recruitment and probation period of staff members This circular has been revised. It cancels and replaces Administrative Circular N° 2 (Rev. 1) - March 2000. Administrative Circular N° 9 (Rev. 3) - May 2004 Staff members contracts This circular has been revised. It cancels and replaces Administrative Circular N° 9 (Rev. 2) - March 2000. Administrative Circular N° 26 (Rev. 4) - May 2004 Procedure governing the career evolution of staff members This circular has also been revised. It Administrative Circulars Administrative Circular N° 26 (Rev. 3) - December 2001 and brings up to date the French version (Rev. 4) published on the HR Department Web site in January 2004. Operational Circular N° 7 - May 2004 Work from home This circular has been drawn up. Operational Circular N° 8 - May 2004 Dealing with alcohol-related problems...

Fulltext PDF

Indian Academy of Sciences (India)

[18] D Rychtarik, B Engeser, H-C Nägerl and R Grimm, Phys. Rev. Lett. 92, 173003. (2004). [19] S Stock, Z Hadzibabic, B Battelier, M Cheneau and J Dalibard, Phys. Rev. Lett. 95,. 190403 (2005). [20] G Hechenblaikner, J M Krueger and C J Foot, Phys. Rev. A71, 013604 (2005). [21] M Schick, Phys. Rev. A3, 1067 (1971).

Project Execution Plan, Rev. 3

International Nuclear Information System (INIS)

IT Corporation, Las Vegas

2002-01-01

This plan addresses project activities encompassed by the U.S. Department of Energy's (DOE's), National Nuclear Security Administration Nevada Operations Office, Environmental Restoration Division and conforms to the requirements contained in the Life-Cycle Asset Management, DOE Order 430.1A; The Joint Program Office Policy on Project Management in Support of DOE Order 430.1; Program and Project Management for the Acquisition of Capital Assets, DOE Order 413.3; the Project Execution and Engineering Management Planning Guide, GPG-FM-010; and other applicable Good Practice Guides; and the FY 2001 Integrated Planning, Accountability, and Budgeting System Policy Guidance. The plan also reflects the milestone philosophies of the Federal Facility Agreement and Consent Order, as agreed to by the State of Nevada, the DOE, and the U.S. Department of Defense; and traditional project management philosophies such as the development of life-cycle costs, schedules, and work scope; identification o f roles and responsibilities; and baseline management and controls

Quantum theory. 2. rev. ed.

International Nuclear Information System (INIS)

Mitter, H.

1979-01-01

This book is an introduction into quantum mechanics. After a general introduction the algebraic calculus of quantum mechanics in the framework of the Dirac brackets is described, whereby the probabilistic interpretation is introduced. Then some simple examples are described in this framework. After a description of the wave representation the general formalism of quantum mechanics is described. Then the Schroedinger equation is introduced. The angular momentum in quantum mechanics is then explicitely discussed. After a treatment of simple one- and two-body problems the parity and the probability current are discussed. Then the approximation methods are described. Finally some applications in atomic physics, simples many-body problems, and the scattering theory are dealed with. In the appendix the delta-function, orthogonal functions, the higher symmetry of the hydrogen problem, and the Galilei transformation in quantum mechanics are described. Every chapter conteins exercise problems. (HSI) [de

Nuclear Propulsion for Space (Rev.)

Energy Technology Data Exchange (ETDEWEB)

Corliss, William R; Schwenk, Francis C

1971-01-01

The operation of nuclear rockets and a description of the development of nuclear rockets in the U.S. is given. Early developments and Project Rover, Project Pluto, and the NERVA (Nuclear Engine for Rocket Vehicle Application) Program are detailed. The Nuclear Rocket Development Station facilities in Nevada are described. The possibilities and advantages of using nuclear rockets for missions beginning from an earth orbit and moving outward toward higher earth orbits, the moon, and the planets are discussed.

Mineralogy. 2. rev., enlarged ed.

International Nuclear Information System (INIS)

Matthes, S.

1987-01-01

The textbook is intended for students with a basic knowledge of descriptive mineralogy and crystallography who wish to enhance their knowledge in the fields of determinative mineralogy, petrology, and the geology and genesis of mineral deposits. The material presented concentrates on the essential aspects of the subject fields and is completed by up-to-date information concerning the technical and economic significance of the minerals, rocks and ores as raw materials. With 165 figs., 2 tabs [de

Food Preservation by Irradiation (Rev.)

Energy Technology Data Exchange (ETDEWEB)

Urrows, Grace M.

1968-01-01

Up to 30% of food harvests are lost in some parts of the world because of animal pests and microorganisms. Nuclear techniques can help reduce and extend the shelf life of these foods. Around 55 countries now have food irradiation programs. The use of radiation is the most recent step in man's attempts to preserve some of his harvest for the lean part of the year.

15 years of Rev Rene

Directory of Open Access Journals (Sweden)

Lorita Marlena Freitag Pagliuca

2015-04-01

Full Text Available Writing an editorial is always a challenge. When drafting a scientific paper one can rely on the literature review, method, results, and discussion with texts supporting or deconstructing what one wants to prove. Utopia is the spice of life, better when there are more than one utopian; particularly a group of dreamers who allowed themselves to dream, not worrying about immediate results; keen to build and preserve a 15-year history. Enter adolescence and be in the world. Create complicity to dream and achieve utopia.

Animals in Atomic Research (Rev.)

Energy Technology Data Exchange (ETDEWEB)

Ricciuti, Edward R. [Bronx Zoo

1969-01-01

This booklet explains what use animals are to science and why they are important to the development of nuclear energy for peaceful uses. It contains examples of the roles animals of many kinds play in the development of nuclear science for the well-being of mankind.

Reactor handbook. 2. rev. ed.

International Nuclear Information System (INIS)

Lederer, B.J.; Wildberg, D.W.

1992-01-01

On the basis of the guidelines on expert knowledge, the book discusses the subjects of atomic physics, heat transfer, nuclear power plants, reactor materials, radiation protection, reactor safety, reactor instrumentation, and reactor operation, with special regard to nuclear power plants with LWR-type reactors. The book is intended for shift personnel, especially gang bosses, reactor operators, and control station operators: for this reason a practical and rather popular style has been chosen. However, the book will also be a manual for other operating personnel, personnel of producer companies, expert organisations, authorities, and students. It can be used as a textbook for staff training, a manual for the practice, and as accompanying book for teaching at nuclear engineering schools. (orig.) With 173 figs [de

The nuclear suicide. Rev. ed.

International Nuclear Information System (INIS)

Gruhl, H.

1988-01-01

The author, one of the most consistent opponents of nuclear power, strikes a balance after the Chernobyl catastrophe. He relentlessly analyses the 'German nuclear situation', developments to be expected from risks and catastrophic events. He exposes statements offered by the owners of power plants and by politicians as attempts to play risks down, and hopes to achieve a turnabout yet. The conjunction of technical and physical arguments with a fundamental criticism of the ideology of economic growth is what distinguishes this book from other publications critical of nuclear energy. But the author does not content himself with criticism, he goes on to point out realistic measures for opting out of nuclear energy. (orig./HSCH) With 10 figs. and maps [de

Nuclear Security: Target Analysis-rev

Energy Technology Data Exchange (ETDEWEB)

Singh, Surinder Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gibbs, Philip W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bultz, Garl A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2014-03-01

The objectives of this presentation are to understand target identification, including roll-up and protracted theft; evaluate target identification in the SNRI; recognize the target characteristics and consequence levels; and understand graded safeguards.

Subconsciously opposed. 2. rev. ed.

International Nuclear Information System (INIS)

Wuenschmann, A.

1982-01-01

The book deals with the emotional aspects of the controversy on peaceful use of nucleon energy. It would be self-delusion to expect a near end of the nuclear discussion. Advocates and opponents confront each other almost beyond reconcilation, handly prepared to hear the opposite side's arguments. What is the reason. As C.F. von Weizsaecker remarked to the author: 'To understand a phenomenon like the present nuclear energy debate is hardly possible without recurring to psychology'. In this paperback an entirely new approach to the nuclear energy debate is opened. The book has found wide attention. As the 'Neue Zuercher Zeitung' wrote: 'The author's psychology analysis of the nuclear energy controversy and especially its interpretation based on Jung's depth psychology combine to form a terse survey of many phenomena not so far systematically studied'. (orig.) [de

Nuclear Energy for Desalting (Rev.)

Energy Technology Data Exchange (ETDEWEB)

Urrows, Grace M.

1967-01-01

This booklet discusses the huge demand for fresh clean water and various ways to create it. Since 3/4 of the world is covered in salt water, many processes have been developed to desalt the salt water. Nuclear-powered desalting units are discussed extensively.

Environmental law. 3. rev. ed.

International Nuclear Information System (INIS)

Anon.

1985-01-01

This pocketbook contains major federal regulations on environmental protection. They serve to protect and cultivate mankind's natural foundations of life, to preserve the environment. The environmental law is devided as follows: Constitutional law on the environment, common administrative law on the environment, special administrative law on the environment including conservation of nature and preservation of rural amenities, protection of waters, waste management, protection against nuisances, nuclear energy and radiation protection, energy conservation, protection against dangerous substances, private law relating to the environment, criminal law relating to the environment. (orig.) [de

Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass.

Science.gov (United States)

Lee, Young-Sam; Gregory, Mark T; Yang, Wei

2014-02-25

DNA polymerase ζ (Pol ζ) is a eukaryotic B-family DNA polymerase that specializes in translesion synthesis and is essential for normal embryogenesis. At a minimum, Pol ζ consists of a catalytic subunit Rev3 and an accessory subunit Rev7. Mammalian Rev3 contains >3,000 residues and is twice as large as the yeast homolog. To date, no vertebrate Pol ζ has been purified for biochemical characterization. Here we report purification of a series of human Rev3 deletion constructs expressed in HEK293 cells and identification of a minimally catalytically active human Pol ζ variant. With a tagged form of an active Pol ζ variant, we isolated two additional accessory subunits of human Pol ζ, PolD2 and PolD3. The purified four-subunit Pol ζ4 (Rev3-Rev7-PolD2-PolD3) is much more efficient and more processive at bypassing a 1,2-intrastrand d(GpG)-cisplatin cross-link than the two-subunit Pol ζ2 (Rev3-Rev7). We show that complete bypass of cisplatin lesions requires Pol η to insert dCTP opposite the 3' guanine and Pol ζ4 to extend the primers.

Revised PROPELLER for T2-weighted imaging of the prostate at 3 Tesla: impact on lesion detection and PI-RADS classification

International Nuclear Information System (INIS)

Meier-Schroers, Michael; Marx, Christian; Schmeel, Frederic Carsten; Wolter, Karsten; Block, Wolfgang; Sprinkart, Alois Martin; Traeber, Frank; Schild, Hans Heinz; Kukuk, Guido Matthias; Gieseke, Juergen; Willinek, Winfried

2018-01-01

To evaluate revised PROPELLER (RevPROP) for T2-weighted imaging (T2WI) of the prostate as a substitute for turbo spin echo (TSE). Three-Tesla MR images of 50 patients with 55 cancer-suspicious lesions were prospectively evaluated. Findings were correlated with histopathology after MRI-guided biopsy. T2 RevPROP, T2 TSE, diffusion-weighted imaging, dynamic contrast enhancement, and MR-spectroscopy were acquired. RevPROP was compared to TSE concerning PI-RADS scores, lesion size, lesion signal-intensity, lesion contrast, artefacts, and image quality. There were 41 carcinomas in 55 cancer-suspicious lesions. RevPROP detected 41 of 41 carcinomas (100%) and 54 of 55 lesions (98.2%). TSE detected 39 of 41 carcinomas (95.1%) and 51 of 55 lesions (92.7%). RevPROP showed fewer artefacts and higher image quality (each p < 0.001). No differences were observed between single and overall PI-RADS scores based on RevPROP or TSE (p = 0.106 and p = 0.107). Lesion size was not different (p = 0.105). T2-signal intensity of lesions was higher and T2-contrast of lesions was lower on RevPROP (each p < 0.001). For prostate cancer detection RevPROP is superior to TSE with respect to motion robustness, image quality and detection rates of lesions. Therefore, RevPROP might be used as a substitute for T2WI. (orig.)

Revised PROPELLER for T2-weighted imaging of the prostate at 3 Tesla: impact on lesion detection and PI-RADS classification

Energy Technology Data Exchange (ETDEWEB)

Meier-Schroers, Michael; Marx, Christian; Schmeel, Frederic Carsten; Wolter, Karsten; Block, Wolfgang; Sprinkart, Alois Martin; Traeber, Frank; Schild, Hans Heinz; Kukuk, Guido Matthias [University Hospital Bonn, Department of Radiology, Bonn (Germany); Gieseke, Juergen [Philips Healthcare Germany, Hamburg (Germany); Willinek, Winfried [Hospital of Barmherzige Brueder, Department of Radiology, Neuroradiology, Sonography and Nuclear Medicine, Trier (Germany)

2018-01-15

To evaluate revised PROPELLER (RevPROP) for T2-weighted imaging (T2WI) of the prostate as a substitute for turbo spin echo (TSE). Three-Tesla MR images of 50 patients with 55 cancer-suspicious lesions were prospectively evaluated. Findings were correlated with histopathology after MRI-guided biopsy. T2 RevPROP, T2 TSE, diffusion-weighted imaging, dynamic contrast enhancement, and MR-spectroscopy were acquired. RevPROP was compared to TSE concerning PI-RADS scores, lesion size, lesion signal-intensity, lesion contrast, artefacts, and image quality. There were 41 carcinomas in 55 cancer-suspicious lesions. RevPROP detected 41 of 41 carcinomas (100%) and 54 of 55 lesions (98.2%). TSE detected 39 of 41 carcinomas (95.1%) and 51 of 55 lesions (92.7%). RevPROP showed fewer artefacts and higher image quality (each p < 0.001). No differences were observed between single and overall PI-RADS scores based on RevPROP or TSE (p = 0.106 and p = 0.107). Lesion size was not different (p = 0.105). T2-signal intensity of lesions was higher and T2-contrast of lesions was lower on RevPROP (each p < 0.001). For prostate cancer detection RevPROP is superior to TSE with respect to motion robustness, image quality and detection rates of lesions. Therefore, RevPROP might be used as a substitute for T2WI. (orig.)

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.

Science.gov (United States)

Breslin, Claire; Mani, Rajam S; Fanta, Mesfin; Hoch, Nicolas; Weinfeld, Michael; Caldecott, Keith W

2017-09-29

The scaffold protein X-ray repair cross-complementing 1 (XRCC1) interacts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) and is important for genetic integrity and normal neurological function. One of the most important interactions of XRCC1 is that with polynucleotide kinase/phosphatase (PNKP), a dual-function DNA kinase/phosphatase that processes damaged DNA termini and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-onset seizures and developmental delay (MCSZ). XRCC1 and PNKP interact via a high-affinity phosphorylation-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP. Here, we identified using biochemical and biophysical approaches a second PNKP interaction site in XRCC1 that binds PNKP with lower affinity and independently of XRCC1 phosphorylation. However, this interaction nevertheless stimulated PNKP activity and promoted SSBR and cell survival. The low-affinity interaction site required the highly conserved Rev1-interacting region (RIR) motif in XRCC1 and included three critical and evolutionarily invariant phenylalanine residues. We propose a bipartite interaction model in which the previously identified high-affinity interaction acts as a molecular tether, holding XRCC1 and PNKP together and thereby promoting the low-affinity interaction identified here, which then stimulates PNKP directly. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Dicty_cDB: Contig-U14872-1 [Dicty_cDB

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Dicty_cDB: Contig-U16276-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available a... 40 3.5 2 ( FE846223 ) CAFI620.rev CAFI Pichia stipitis aerobic dextrose... 4...d CAGN Nematostella vectensis Nemve m... 40 3.5 2 ( FE846046 ) CAFI523.rev CAFI Pichia stipitis aerobic dextrose...gen limited x... 44 3.7 2 ( FE846047 ) CAFI523.fwd CAFI Pichia stipitis aerobic dextrose... 44 3.7 2 ( FE855...845941 ) CAFI467.rev CAFI Pichia stipitis aerobic dextrose... 44 3.7 2 ( FE851411 ) CAFP1701.rev CAFP Pichia... stipitis aerobic xylose ... 44 3.8 2 ( FE846903 ) CAFI979.rev CAFI Pichia stipitis aerobic dextrose

Reply to "Comment on `Particle path through a nested Mach-Zehnder interferometer' "

Science.gov (United States)

Griffiths, Robert B.

2018-02-01

While much of the technical analysis in the preceding Comment is correct, in the end it confirms the conclusion reached in my previous work [Phys. Rev. A 94, 032115 (2016), 10.1103/PhysRevA.94.032115]: A consistent histories analysis provides no support for the claim of counterfactual quantum communication put forward by Salih et al. [Phys. Rev. Lett. 110, 170502 (2013), 10.1103/PhysRevLett.110.170502].

Dicty_cDB: Contig-U15843-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available BHY5562.rev CBHY Mycosphaerella fijiensis MfEST5... 36 7.1 2 ( BQ114953 ) EST600529 mixed potato tissues Sol...lus trich... 36 7.1 2 ( FD665298 ) CBBW522.rev CBBW Mycosphaerella fijiensis MfEST4 ... 36 7.1 2 ( FD692768 ...) CBHY4190.rev CBHY Mycosphaerella fijiensis MfEST5... 36 7.1 2 ( BP035364 ) Lotus japonicus cDNA, clone:MFB... 7.3 2 ( BF053354 ) EST438584 potato leaves and petioles Solanum tube... 36 7.3 2 ( FD686209 ) CBHX5588.rev CBHX Mycosphaerella fiji...ensis MfEST4... 36 7.3 2 ( FD687727 ) CBHY1213.rev CBHY Mycosphaerella fijiensis MfE

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 3, Revision 2 (FGE.03Rev2): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate one flavouring substance, acetaldehyde ethyl isopropyl acetal [FL-no: 06.137], structurally related to the 58 flavouring substances in the Flavouring Group...... on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded as for the other already evaluated substances that the substance [FL-no: 06.137] do not give rise to safety concern at its level of dietary...... intake, estimated on the basis of the MSDI approach. Besides the safety assessment of this flavouring substance, the specifications for the materials of commerce have also been considered, and since the publication of FGE.03Rev1 additional information on chirality on 30 substances is made available...

Selective suppression of autocatalytic caspase-3 driven by two-step transcriptional amplified human telomerase reverse transcriptase promoter on ovarian carcinoma growth in vitro and in mice.

Science.gov (United States)

Song, Yue; Xin, Xing; Xia, Zhijun; Zhai, Xingyue; Shen, Keng

2014-07-01

The objective of our study was to construct recombinant adenovirus (rAd) AdHTVP2G5-rev-casp3, which expresses autocatalytic caspase-3 driven by human telomerase reverse transcriptase promoter (hTERTp) with a two-step transcription amplification (TSTA) system and investigate its antitumor effects on ovarian cancer in vitro and in vivo. Fluorescent detection was used to detect EGFP expression in various cells. Cell viabilities were determined using the Cell Counting Kit-8 and flow cytometry. RT-PCR and immunoblotting assays were used to detect cellular apoptotic activities. Tumor growth and survival of tumor-bearing mice were studied. The hTERTp-TSTA system showed the strongest activity in hTERT-positive cancer cells when compared with hTERTp and cytomeglovirus promoter (CMVp). In contrast, it showed no activity in hTERT‑negative HUVECs. AdHTVP2G5‑rev-casp3 markedly suppressed the survival of AO cells in a dose-dependent modality with a viability rate of 17.8 ± 3.5% at an MOI of 70, which was significantly lower than that by AdHT-rev-casp3 and Ad-rev-casp3 (rAds which express rev-caspase-3 driven by hTERTp and CMVp, respectively). In contrast, AdHTVP2G5‑rev-casp3 induced little HUVEC death with a viability rate of 92.7 ± 5.2% at the same MOI. Additionally, AdHTVP2G5-rev-casp3 (MOI=70) caused significant apoptosis in AO cells with an apoptotic rate of 42%. The tumor growth suppression rate of AdHTVP2G5-rev-casp3 was 81.52%, significantly higher than that of AdHT-rev-casp3 (54.94%) or Ad-rev-casp3 (21.35%). AdHTVP2G5-rev-casp3 significantly improved the survival of tumor-bearing mice with little liver damage, with a mean survival of 258 ± 28 days. These results showed that AdHTVP2G5-rev-casp3 caused effective apoptosis with significant tumor selectivity, strongly suppressed tumor growth and improved mouse survival with little liver toxicity. It can be a potent therapeutic agent for tumor targeted treatment of ovarian cancer.

Dicty_cDB: Contig-U03947-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 938 ) CBBP4410.fwd CBBP Hirudo medicinalis hermaphrodit... 48 0.31 1 ( EY498937 ) CBBP4410.rev CBBP Hirudo medicina... 1.2 1 ( EY492936 ) CBBP19197.fwd CBBP Hirudo medicinalis hermaphrodi... 46 1.2 1 ( EY492935 ) CBBP19197.rev CBBP Hirudo medicina...lis hermaphrodi... 46 1.2 1 ( EY484758 ) CBBP13781.rev CBBP Hirudo medicina...lis hermaphrodi... 46 1.2 1 ( EY482704 ) CBBP12533.rev CBBP Hirudo medicinalis hermaphrodi...

Reply to "Comment on `Protecting bipartite entanglement by quantum interferences' "

Science.gov (United States)

Das, Sumanta; Agarwal, G. S.

2018-03-01

In a recent Comment Nair and Arun, Phys. Rev. A 97, 036301 (2018), 10.1103/PhysRevA.97.036301, it was concluded that the two-qubit entanglement protection reported in our work [Das and Agarwal, Phys. Rev. A 81, 052341 (2010), 10.1103/PhysRevA.81.052341] is erroneous. While we acknowledge the error in analytical results on concurrence when dipole matrix elements were unequal, the essential conclusions on entanglement protection are not affected.

Dicty_cDB: Contig-U15690-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available ta cDNA 5', mRNA seq... 46 7.4 1 ( FD689772 ) CBHY2434.fwd CBHY Mycosphaerella fijiensis MfEST5... 46 7.4 1 ...( FD689771 ) CBHY2434.rev CBHY Mycosphaerella fijiensis MfEST5... 46 7.4 1 ( FD681956 ) CBHW747.rev CBHW Mycosphaerella fiji...ensis MfEST4 ... 46 7.4 1 ( FD681900 ) CBHW717.rev CBHW Mycosphaerella fiji...ensis MfEST4 ... 46 7.4 1 ( FD680197 ) CBHW396.rev CBHW Mycosphaerella fijiensis MfEST4 ... 46 7.4... 1 ( FD679925 ) CBHW3049.rev CBHW Mycosphaerella fijiensis MfEST4... 46 7.4 1 ( FD505746 ) Pam01b_67_B04_C01

The furrows of Rhinolophidae revisited

OpenAIRE

Vanderelst, Dieter; Jonas, Reijniers; Herbert, Peremans

2012-01-01

Rhinolophidae, a family of echolocating bats, feature very baroque noseleaves that are assumed to shape their emission beam. Zhuang & Muller (Zhuang & Muller 2006 Phys. Rev. Lett. 97, 218701 (doi:10.1103/PhysRevLett.97.218701); Zhuang & Muller 2007 Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(Pt. 1), 051902 (doi:10.1103/PhysRevE.76.051902)) have proposed, based on finite element simulations, that the furrows present in the noseleaves of these bats act as resonance cavities. Using Rhinoloph...

Dicty_cDB: Contig-U11442-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 8 2 ( FE844906 ) CAFH679.rev CAFH Pichia stipitis aerobic dextrose... 32 9.8 2 ( FE857272 ) CAFW1111.rev CAF...... 34 9.8 2 ( FE846369 ) CAFI697.rev CAFI Pichia stipitis aerobic dextrose... 32 9.8 2 ( FE856098 ) CAFU451

Complete set of essential parameters of an effective theory

Science.gov (United States)

Ioffe, M. V.; Vereshagin, V. V.

2018-04-01

The present paper continues the series [V. V. Vereshagin, True self-energy function and reducibility in effective scalar theories, Phys. Rev. D 89, 125022 (2014); , 10.1103/PhysRevD.89.125022A. Vereshagin and V. Vereshagin, Resultant parameters of effective theory, Phys. Rev. D 69, 025002 (2004); , 10.1103/PhysRevD.69.025002K. Semenov-Tian-Shansky, A. Vereshagin, and V. Vereshagin, S-matrix renormalization in effective theories, Phys. Rev. D 73, 025020 (2006), 10.1103/PhysRevD.73.025020] devoted to the systematic study of effective scattering theories. We consider matrix elements of the effective Lagrangian monomials (in the interaction picture) of arbitrary high dimension D and show that the full set of corresponding coupling constants contains parameters of both kinds: essential and redundant. Since it would be pointless to formulate renormalization prescriptions for redundant parameters, it is necessary to select the full set of the essential ones. This is done in the present paper for the case of the single scalar field.

Reversible polymorphism-aware phylogenetic models and their application to tree inference.

Science.gov (United States)

Schrempf, Dominik; Minh, Bui Quang; De Maio, Nicola; von Haeseler, Arndt; Kosiol, Carolin

2016-10-21

We present a reversible Polymorphism-Aware Phylogenetic Model (revPoMo) for species tree estimation from genome-wide data. revPoMo enables the reconstruction of large scale species trees for many within-species samples. It expands the alphabet of DNA substitution models to include polymorphic states, thereby, naturally accounting for incomplete lineage sorting. We implemented revPoMo in the maximum likelihood software IQ-TREE. A simulation study and an application to great apes data show that the runtimes of our approach and standard substitution models are comparable but that revPoMo has much better accuracy in estimating trees, divergence times and mutation rates. The advantage of revPoMo is that an increase of sample size per species improves estimations but does not increase runtime. Therefore, revPoMo is a valuable tool with several applications, from speciation dating to species tree reconstruction. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

The European Food Safety Authority (EFSA) asked the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs...... in the Member States. In particular, the Panel was requested to evaluate 19 flavouring substances in the Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 19 flavouring substances belong to chemical groups 15, 16, 22......-no: 03.022] Industry has informed that it occurs as a mixture of E- & Z-isomers, however, the composition of the mixture has to be specified. Two of the flavouring substances are classified into structural class I, seven are classified into structural class II and 10 are classified into structural class...

EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 220, Revision 1 (FGE.220Rev1): alpha,beta-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones

DEFF Research Database (Denmark)

Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

in the Member States. In particular, the Panel was asked to evaluate flavouring substances using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The present revision of FGE.220, FGE.220Rev1, concerns the evaluation of additional data submitted by Industry in response...... was alleviated, since one of the substances, for which positive genotoxicity data in mice were obtained, was not carcinogenic in a valid chronic assay in rats. Therefore, no further genotoxicity tests in somatic cells were required. However, some evidence was also available that this substance might elicit...... was requested. In March 2009 the Flavouring Industry submitted new data in reply to the above requested data for subgroup 4.4b of FGE.220. These data have now been examined by the Panel which has concluded the following. The results of a valid rat fertility and dominant lethal study have shown...

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 73, Revision 3 (FGE.73Rev3): Consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... of one additional substance, beta-ionyl acetate [FL-no: 09.305] cleared for genotoxicity concern in FGE.213Rev1. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern.......712] considered in this FGE and agrees with the JECFA conclusion, “No safety concern at estimated levels of intake as flavouring substances” based on the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered...

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 12, Revision 4 (FGE.12Rev4): primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters from chemical groups 1 and 7

DEFF Research Database (Denmark)

Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 12 flavouring substances in Flavouring Group Evaluation 12, Revision 4 (FGE.12Rev4), including two additional substances, using the Procedure in Commission...... (the Procedure) that integrates information on structure–activity relationships, intake from current uses and the toxicological threshold of concern and available data on metabolism and toxicity. The Panel concluded that none of the 12 substances [FL-nos: 02.134, 02.186, 02.216, 02.217, 05.157, 05.......182, 05.183, 05.198, 08.135, 09.342, 09.670 and 09.829] gives rise to safety concerns at their levels of dietary intake, estimated on the basis of the maximised survey-derived daily intake approach. Besides the safety assessment of these flavouring substances, the specifications for the materials...

Background field removal technique using regularization enabled sophisticated harmonic artifact reduction for phase data with varying kernel sizes.

Science.gov (United States)

Kan, Hirohito; Kasai, Harumasa; Arai, Nobuyuki; Kunitomo, Hiroshi; Hirose, Yasujiro; Shibamoto, Yuta

2016-09-01

An effective background field removal technique is desired for more accurate quantitative susceptibility mapping (QSM) prior to dipole inversion. The aim of this study was to evaluate the accuracy of regularization enabled sophisticated harmonic artifact reduction for phase data with varying spherical kernel sizes (REV-SHARP) method using a three-dimensional head phantom and human brain data. The proposed REV-SHARP method used the spherical mean value operation and Tikhonov regularization in the deconvolution process, with varying 2-14mm kernel sizes. The kernel sizes were gradually reduced, similar to the SHARP with varying spherical kernel (VSHARP) method. We determined the relative errors and relationships between the true local field and estimated local field in REV-SHARP, VSHARP, projection onto dipole fields (PDF), and regularization enabled SHARP (RESHARP). Human experiment was also conducted using REV-SHARP, VSHARP, PDF, and RESHARP. The relative errors in the numerical phantom study were 0.386, 0.448, 0.838, and 0.452 for REV-SHARP, VSHARP, PDF, and RESHARP. REV-SHARP result exhibited the highest correlation between the true local field and estimated local field. The linear regression slopes were 1.005, 1.124, 0.988, and 0.536 for REV-SHARP, VSHARP, PDF, and RESHARP in regions of interest on the three-dimensional head phantom. In human experiments, no obvious errors due to artifacts were present in REV-SHARP. The proposed REV-SHARP is a new method combined with variable spherical kernel size and Tikhonov regularization. This technique might make it possible to be more accurate backgroud field removal and help to achive better accuracy of QSM. Copyright © 2016 Elsevier Inc. All rights reserved.

Autocatalytic caspase-3 driven by human telomerase reverse transcriptase promoter suppresses human ovarian carcinoma growth in vitro and in mice.

Science.gov (United States)

Song, Yue; Xia, Zhijun; Shen, Keng; Zhai, Xingyue

2013-05-01

To construct recombinant adenoviruses AdHT-rev-casp3 and Ad-rev-casp3, which express autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter and cytomegalovirus promoter, respectively; and to investigate their antitumor effects on ovarian cancer in vitro and in vivo. Cell viabilities were determined using the cell counting kit 8 and flow cytometry. Reverse transcriptase polymerase chain reaction and immunoblotting assays were used to detect cellular apoptotic activities after treatments. Tumor growth and survival of mice bearing AO cells were studied. AdHT-rev-casp3 significantly suppressed the survival of AO cells in a dose-dependent modality with a viability rate of 60.45% ± 7.8% at an multiplicity of infection (MOI) of 70 and 42.18 ± 5.3% at an MOI of 100, which was somewhat lower than that of the AO cells treated with Ad-rev-casp3 (32.28% ± 5.3% and 21.84% ± 3.4%, respectively). In contrast, AdHT-rev-casp3 induced little human umbilical vein epithelial cell (HUVEC) death with a viability rate of 98.52% ± 6.9% at an MOI of 70, whereas Ad-rev-casp3 induced significant cell death in HUVEC with a viability rate of 27.14% ± 5.4%. Additionally, AdHT-rev-casp3 (MOI = 70) caused significant apoptosis in AO cells with an apoptotic rate of 25.97%, whereas it caused undetectable apoptosis in HUVECs with the rate of only 1.75%. Ad-rev-casp3 (MOI = 70) caused strong apoptosis in both AO and HUVECs, with the rate of 35.82% and 38.12%, respectively. AdHT-rev-casp3 caused markedly higher levels of active caspase-3, causing no detectable active caspase-3 expression in HUVECs. The tumor growth suppression rate of AdHT-rev-casp3 was 54.94%, significantly higher than that of phosphate-buffered saline at the end point of the study. AdHT-rev-casp3 significantly improved the survival of mice receiving intraperitoneal inoculation of AO cells with little liver damage, with the mean survival of 177 ± 12 days. AdHT-rev-casp3 causes effective apoptosis

Identification of Optimal Reference Genes for Normalization of qPCR Analysis during Pepper Fruit Development

Directory of Open Access Journals (Sweden)

Yuan Cheng

2017-06-01

Full Text Available Due to its high sensitivity and reproducibility, quantitative real-time PCR (qPCR is practiced as a useful research tool for targeted gene expression analysis. For qPCR operations, the normalization with suitable reference genes (RGs is a crucial step that eventually determines the reliability of the obtained results. Although pepper is considered an ideal model plant for the study of non-climacteric fruit development, at present no specific RG have been developed or validated for the qPCR analyses of pepper fruit. Therefore, this study aimed to identify stably expressed genes for their potential use as RGs in pepper fruit studies. Initially, a total of 35 putative RGs were selected by mining the pepper transcriptome data sets derived from the PGP (Pepper Genome Platform and PGD (Pepper Genome Database. Their expression stabilities were further measured in a set of pepper (Capsicum annuum L. var. 007e fruit samples, which represented four different fruit developmental stages (IM: Immature; MG: Mature green; B: Break; MR: Mature red using the qPCR analysis. Then, based on the qPCR results, three different statistical algorithms, namely geNorm, Normfinder, and boxplot, were chosen to evaluate the expression stabilities of these putative RGs. It should be noted that nine genes were proven to be qualified as RGs during pepper fruit development, namely CaREV05 (CA00g79660; CaREV08 (CA06g02180; CaREV09 (CA06g05650; CaREV16 (Capana12g002666; CaREV21 (Capana10g001439; CaREV23 (Capana05g000680; CaREV26 (Capana01g002973; CaREV27 (Capana11g000123; CaREV31 (Capana04g002411; and CaREV33 (Capana08g001826. Further analysis based on geNorm suggested that the application of the two most stably expressed genes (CaREV05 and CaREV08 would provide optimal transcript normalization in the qPCR experiments. Therefore, a new and comprehensive strategy for the identification of optimal RGs was developed. This strategy allowed for the effective normalization of the q

Comment on "Many-body localization in Ising models with random long-range interactions"

Science.gov (United States)

Maksymov, Andrii O.; Rahman, Noah; Kapit, Eliot; Burin, Alexander L.

2017-11-01

This Comment is dedicated to the investigation of many-body localization in a quantum Ising model with long-range power-law interactions r-α, relevant for a variety of systems ranging from electrons in Anderson insulators to spin excitations in chains of cold atoms. It has earlier been argued [arXiv:cond-mat/0611387 (2005); Phys. Rev. B 91, 094202 (2015), 10.1103/PhysRevB.91.094202] that this model obeys the dimensional constraint suggesting the delocalization of all finite-temperature states in the thermodynamic limit for α ≤2 d in a d -dimensional system. This expectation conflicts with the recent numerical studies of the specific interacting spin model of Li et al. [Phys. Rev. A 94, 063625 (2016), 10.1103/PhysRevA.94.063625]. To resolve this controversy we reexamine the model of Li et al. [Phys. Rev. A 94, 063625 (2016), 10.1103/PhysRevA.94.063625] and demonstrate that the infinite-temperature states there obey the dimensional constraint. The earlier developed scaling theory for the critical system size required for delocalization is extended to small exponents 0 ≤α ≤d . The disagreements between the two works are explained by the nonstandard selection of investigated states in the ordered phase in the work of Li et al. [Phys. Rev. A 94, 063625 (2016)type="doi" specific-use="suppress-display">10.1103/PhysRevA.94.063625].

Geologic thickness data: Candidate repository horizons

International Nuclear Information System (INIS)

Cross, R.W.; Fairchild, K.R.

1985-01-01

This data package contains information on the thickness of the Umtanum, McCoy Canyon, Cohassett, and Rocky Coulee flows and their intraflow structures in 20 boreholes and 2 surface sections in the Pasco Basin. Thickness data are for total flow, flow top, entablature, and colonnade (or just flow top and dense interior in some cases). Summary figures which contain descriptions and footages are included. SD-BWI-DP-011, Rev. 2 replaces SD-BWI-DP-011, Rev. A-0 in its entirety. (Rev. A-0 replaced Rev. 0-0.) 5 refs

Dicty_cDB: Contig-U15540-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 0 9e-05 4 ( EY486647 ) CBBP15317.rev CBBP Hirudo medicinalis hermaphrodi... 40 1e...86493 ) CBBP15224.rev CBBP Hirudo medicinalis hermaphrodi... 40 0.005 3 ( BV631576 ) S215P61384RC7.T0 Clara ...um discoideum DIF insensitive mutant A... 34 0.012 8 ( EY490670 ) CBBP17785.rev CBBP Hirudo medicinalis herm...1 ) CBBP4538.rev CBBP Hirudo medicinalis hermaphrodit... 40 0.014 4 ( AC116984 ) ...a robusta Subtracted E... 36 0.024 3 ( EY492625 ) CBBP18994.fwd CBBP Hirudo medicinalis hermaphrodi... 38 0.

International Conference on Defects in Semiconductors (19th), ICDS-19, Held in Aveiro, Portugal on 21-25 July 1997, Part 2

Science.gov (United States)

1998-01-23

Rudolf , C. Nagel, S. Eichler, and R. Krause-Rehberg; Phys. Rev. B 55, 10467 (1997). [19] M. J. Puska and R.M. Nieminen; Rev. Mod. Phys. 66, 841 (1994...54, 7909 (1996). [17] C. Corbel, F. Pierre, K. Saarinen, P. Hautojärvi, and P. Moser; Phys. Rev. B 45, 3386 (1992); A. Polity, F. Rudolf , C. Nagel, S...T. W. Steiner , M. K. Nissen, S. M. Wilson, Y. Lacroix, and M. L. W. Thewalt, Phys. Rev. B 47, 1265 (1993). [15] C. Ziegler, U. Scherz, and M

Adaptive clustering procedure for continuous gravitational wave searches

Science.gov (United States)

Singh, Avneet; Papa, Maria Alessandra; Eggenstein, Heinz-Bernd; Walsh, Sinéad

2017-10-01

In hierarchical searches for continuous gravitational waves, clustering of candidates is an important post-processing step because it reduces the number of noise candidates that are followed up at successive stages [J. Aasi et al., Phys. Rev. Lett. 88, 102002 (2013), 10.1103/PhysRevD.88.102002; B. Behnke, M. A. Papa, and R. Prix, Phys. Rev. D 91, 064007 (2015), 10.1103/PhysRevD.91.064007; M. A. Papa et al., Phys. Rev. D 94, 122006 (2016), 10.1103/PhysRevD.94.122006]. Previous clustering procedures bundled together nearby candidates ascribing them to the same root cause (be it a signal or a disturbance), based on a predefined cluster volume. In this paper, we present a procedure that adapts the cluster volume to the data itself and checks for consistency of such volume with what is expected from a signal. This significantly improves the noise rejection capabilities at fixed detection threshold, and at fixed computing resources for the follow-up stages, this results in an overall more sensitive search. This new procedure was employed in the first Einstein@Home search on data from the first science run of the advanced LIGO detectors (O1) [LIGO Scientific Collaboration and Virgo Collaboration, arXiv:1707.02669 [Phys. Rev. D (to be published)

Crack Detectability in Vertical Axis Cooling Pumps During Operation

Directory of Open Access Journals (Sweden)

N. Bachschmid

2004-01-01

in a position which is rather far away from the crack. 1 × rev., 2 × rev., and 3 × rev. vibration components, which are generally displayed by the machine condition monitoring system and are the most significative symptoms of the presence of a transverse crack in a rotating shaft, are calculated.

Department of Defense Federal Supply Classification Listing of DoD standardization Documents

Science.gov (United States)

1989-07-01

MIL-D-2222F GL 29 Mar 85 GL MC CS 7320 Dough Trough, Fermentation , Field USER-MC REV-MD SA 84 GS... Yogurt Mixes Validated Jan 85 REV-MD MS MC SS.. MIL-I 43717C (1) GL 04 May 79 GL NU 50 8910 Malted Milk Validated Jan 80 REV.MD MC SS

Vaccination of High-Risk Breast Cancer Patients with Carbohydrate Mimicking Peptides

Science.gov (United States)

2009-05-01

animals ANCA006 – CO2 Euthanasia Rev 1 ANCA007 – Rodent Quarantine Rev 1 ANCA008 – Animal Feeding & Bedding ANCA009 – Rodent Ear Marking Rev...participating in it. A clear statement will be made concerning the voluntary nature of her participation and that her decision will have no effect on her...

Reply to "Comment on `Conductance scaling in Kondo-correlated quantum dots: Role of level asymmetry and charging energy'"

Science.gov (United States)

Merker, L.; Kirchner, S.; Muñoz, E.; Costi, T. A.

2014-08-01

The Comment of A. A. Aligia claims that the superperturbation theory (SPT) approach [E. Muñoz, C. J. Bolech, and S. Kirchner, Phys. Rev. Lett. 110, 016601 (2013), 10.1103/PhysRevLett.110.016601] formulated using dual fermions [A. N. Rubtsov, M. I. Katsnelson, and A. I. Lichtenstein, Phys. Rev. B 77, 033101 (2008), 10.1103/PhysRevB.77.033101] and used by us to compare with numerical renormalization group (NRG) results for the conductance [L. Merker, S. Kirchner, E. Muñoz, and T. A. Costi, Phys. Rev. B 87, 165132 (2013), 10.1103/PhysRevB.87.165132], fails to correctly extend the results of the symmetric Anderson impurity model (SIAM) for general values of the local level Ed in the Kondo regime. We answer this criticism. We also compare new NRG results for cB, with cB calculated directly from the low-field conductance, with new higher-order SPT calculations for this quantity, finding excellent agreement for all Ed and for U /πΔ extending into the strong coupling regime.

Reply to ``Comment on `Attractive forces between ions in quantum plasmas: Failure of linearized quantum hydrodynamics' ''

Science.gov (United States)

Bonitz, M.; Pehlke, E.; Schoof, T.

2013-03-01

This is the last of a series of three papers. In the first [Phys. Rev. E10.1103/PhysRevE.87.033105 87, 033105 (2013)], the same authors presented a critical analysis of the prediction of “novel attractive forces” between protons in dense hydrogen put forward by Shukla and Eliasson in a recent Letter [Phys. Rev. Lett.10.1103/PhysRevLett.108.165007 108, 165007 (2012)]. Based on ab initio density functional theory (DFT) calculations and general considerations, it was shown that no such force exists. In the second of the three papers [Phys. Rev. E10.1103/PhysRevE.87.037101 87, 037101 (2013)], Shukla, Eliasson, and Akbari-Moghanjoughi (SEA) rejected this analysis. SEA did not discuss our arguments but claimed that the discrepancy between their quantum hydrodynamic model (QHD) and DFT is due to a failure of the latter. It is the purpose of the present Reply to demonstrate that this claim is incorrect because DFT is more accurate than QHD, by construction.

Long-term evolution and revival structure of Rydberg wave packets

International Nuclear Information System (INIS)

Bluhm, R.

1995-01-01

It is known that, after formation, a Rydberg wave packet undergoes a series of collapses and revivals within a time period called the revival time, t rev , at the end of which it is close to its original shape. We study the behavior of Rydberg wave packets on time scales much greater than t rev . We show that after a few revival cycles the wave packet ceases to reform at multiples of the revival time. Instead, a new series of collapses and revivals commences, culminating after a time period t sr >>t rev with the formation of a wave packet that more closely resembles the initial packet than does the full revival at time t rev . Furthermore, at times that are rational fractions of t sr , the square of the autocorrelation function exhibits large peaks with periodicities that can be expressed as fractions of the revival time t rev . These periodicities indicate a new type of fractional revival occurring for times much greater than t rev . A theoretical explanation of these effects is outlined. ((orig.))

Quantum Matter : Life beyond symmetries

Indian Academy of Sciences (India)

Collaborators. •. Phys. Rev. Lett. 115, 116803 (2015). •. Phys. Rev. Lett. 115, 267209 (2015). •. Phys. Rev. B 93, 195143 (2016). •. arXiv: 1603.05109 (2016). References. • Y. B. Kim, U. Toronto. • K. Dhochak, ICTS. • S. Sanyal, ICTS. • A. Nanda, ICTS. Funding. •. SERB, Early Career Grant. •. MPI-Partner Group ...

Comment on ''Systematic description of evaporation spectra for light and heavy compound nuclei''

International Nuclear Information System (INIS)

Aktaev, N. E.; Gontchar, I. I.

2010-01-01

Contrary to what is claimed in the article by R. J. Charity [Phys. Rev. C 82, 014610 (2010)], the papers by Gontchar and Aktaev [Phys. Rev. C 80, 044601 (2009)] and Lestone and McCalla [Phys. Rev. C 79, 044611 (2009)] do not contradict but rather complement each other with respect to the time delay of the fission process.

A review of the New World Atteva Walker moths (Yponomeutidae, Attevinae Resenha das mariposas do gênero Atteva Walker do Novo Mundo (Yponomeutidae, Attevinae

Directory of Open Access Journals (Sweden)

Vitor O. Becker

2009-01-01

Full Text Available The New World species of Atteva Walker are reviewed and illustrated in colour. One name: A. pustulella (Fabricius, nom. rev. and three species: A. aurea (Fitch, sp. rev., A. floridana (Neumoegen, sp. rev. and A. gemmata (Grote, sp. rev. are reinstated; five names are synonymised under A. aurea: Poeciloptera compta Clemens, syn. n., A. edithella Busck, syn. n., A. exquisita Busck, syn. n., A. ergatica Walsingham, syn. n. and A. microsticta Walsingham, syn. n.; four new species are described: A. rawlinsi sp. n., from the Dominican Republic, A. sidereoides sp. n., from Jamaica, A. entermedia sp. n., from Antigua, and A. zebrina sp. n., from Brazil; lectotypes for A. floridana and A. glaucopidella (Guenée (=fulviguttata are also designated.As species de Atteva Walker são revistas e ilustradas em cores. Um nome: A. pustulella (Fabricius, nom. rev. e três espécies: A. aurea (Fitch, sp. rev., A. floridana (Neumoegen, sp. rev. and A. gemmata (Grote, sp. rev. são restabelecidos; cinco nomes são considerados sinônimos recentes de A.aurea: Poeciloptera compta Clemens, syn. n., A. edithella Busck, syn. n., A. exquisita Busck, syn. n., A. ergatica Walsingham, syn. n. e A. microsticta Walsingham, syn. n.; quatro espécies novas são descritas: A. rawlinsi sp. n., da República Dominica, A. sidereoides sp. n., da Jamaica, A. entermedia sp. n., de Antigua, e A. zebrina sp. n., do Brazil; são designados lectótipos para A. floridana e A. glaucopidella (Guenée (=fulviguttata.

Dicty_cDB: Contig-U11786-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available spleen cDNA, RIKEN full-le... 52 0.057 1 ( EY502489 ) CBBP6397.rev CBBP Hirudo medicinalis hermaphrodit... ...52 0.057 1 ( EY501142 ) CBBP5660.rev CBBP Hirudo medicinalis hermaphrodit... 52 0.057 1 ( EY498689 ) CBBP4264.fwd CBBP Hirudo medicin...alis hermaphrodit... 52 0.057 1 ( EY496087 ) CBBP2702.rev CBBP Hirudo medicina...lis hermaphrodit... 52 0.057 1 ( EY495298 ) CBBP2215.fwd CBBP Hirudo medicinalis herma...phrodit... 52 0.057 1 ( EY486742 ) CBBP15371.rev CBBP Hirudo medicinalis hermaphrodi... 52 0.057 1 ( EY30352

ENDF/B-5 Actinides (Rev. 86)

International Nuclear Information System (INIS)

Lemmel, H.D.

1986-05-01

This document summarizes the contents of the Actinides part of the ENDF/B-5 nuclear data library released by the US National Nuclear Data Center. This library or selective retrievals of it, are available costfree from the IAEA Nuclear Data Section upon request. The present version of the library is the Revision of 1986. (author). Refs, figs and tabs

Occupational safety manual. 4. rev. ed.

International Nuclear Information System (INIS)

Skiba, R.

1979-01-01

With the rapid technical development and increasing life expectancy, protection against occupational hazards has become a central economic and social problem. Consultants and others responsible for occupational safety should not only be interested in their work but also have sufficient basic knowledge. The complex subject is presented in a simplified and easily comprehensible manner, with particular regard to the practical side. The book is at the same time a textbook for basic training and a reference manual for the working practice. (orig./HP) [de

Instructor Revs Up Ailing Motorcycle Program

Science.gov (United States)

Stevenson, Roy

2011-01-01

Bob Monroig smiles every day on his way to work at Lake Washington Technical College (LWTC), high atop a hill overlooking the affluent Seattle suburb of Kirkland, Washington. He's created his own job within a job, where he's the Harley-Davidson University program coordinator and tenured faculty in the Motorcycle, Marine, & Power Equipment…

The ecological atlas. 3. rev. ed.

International Nuclear Information System (INIS)

Seager, J.

1993-01-01

''The ecological atlas'' translates expert knowledge in a way that makes it accessable to the general public. In 37 double sided maps in four colours it gives information about the health of our planet and the quality of human life. Under 8 different angles: (the earth's habitat, food and drinking water, housing, energy, industry, armament, consumer needs and 'green politics'). ''The ecological atlas'' describes the effects of worldwide ecological effects: climatic disasters, the greenhouse effect, the hole in the ozone layer, destruction of the tropical rainforests, the effects of extensive farming and increasing urbanization. Pages of comprehensive commentaries complement the maps and aid understanding of their problem areas. (orig./DG) [de

Diagnostic nuclear medicine. 2. rev. ed.

International Nuclear Information System (INIS)

Schiepers, C.

2006-01-01

The field of nuclear medicine is undergoing rapid expansion, and is evolving into diagnostic molecular imaging. During recent years, dual-modality imaging with PET/CT has gained acceptance and this is currently the fastest-growing technique for oncological imaging applications. The glucose analogue FDG has held its place in diagnostic oncology, assessment of myocardial viability and diagnosis of neuro-degenerative disorders. Peptides have become even more important as imaging agents. The accuracy of hepatobiliary scintigraphy has been enhanced by cholecystokinin. The use of ACE inhibitors in the evaluation of renovascular hypertension has become the standard in renography. New instrumentation has led to faster scanners, and computer development to better image processing software. Automatic processing is more common, and standardization of protocols can be accomplished easily. The field of gene imaging has progressed, although routine clinical applications are not yet available. The present text, supplemented with many detailed and informative illustrations, represents an adjunct to the standard knowledge of diagnostic nuclear medicine and provides both the student and the professional with an overview of developments during the past decade. (orig.)

Industrial inorganic chemistry. 2. rev. ed.

International Nuclear Information System (INIS)

Buechner, W.; Schliebs, R.; Winter, G.; Buechel, K.H.

1986-01-01

Inorganic chemistry is a branch of considerable economic and technical importance. Apart from supplying the market with metals, fertilizers, building materials, pigments and glass it is one of the major suppliers of process materials to the organic chemical industry. Many modern products of other industrial sectors (video tapes, optical fibers or silicon chips) could not have been developed and manufactured without the achievements of industrial inorganic chemistry. The publication is the first of its kind to give a compact description of the inorganic chemistry sector. A clearly arranged survey facilitates access to production processes, economic aspects, ecological implications, energy consumption and raw material consumption as well as to many other data and facts. Due to its clear arrangement and the combination of technical and economic facts the book is a valuable source of information. (orig./EF) [de

Radiology. 3. rev. and enl. ed.

International Nuclear Information System (INIS)

Reiser, Maximilian; Kuhn, Fritz-Peter; Debus, Juergen

2011-01-01

The text book on radiology covers the following issues: Part A: General radiology: Fundamental physics: radiation biology; radiation protection fundamentals: radiologic methods; radiotherapy; nuclear medicine. Part B: Special radiology: Thorax; heart; urogenital tract and retroperitoneum; vascular system and interventional radiology; esophagus, stomach, small and large intestines; liver, biliary system, pancreas and spleen; mammary glands; central nervous system; spinal cord and spinal canal; basis of the skull, facial bones and eye socket; neck; pediatric imaging diagnostics.

Project Execution Plan,Rev. 3; FINAL

International Nuclear Information System (INIS)

IT Corporation, Las Vegas

2002-01-01

This plan addresses project activities encompassed by the U.S. Department of Energy's (DOE's), National Nuclear Security Administration Nevada Operations Office, Environmental Restoration Division and conforms to the requirements contained in the Life-Cycle Asset Management, DOE Order 430.1A; The Joint Program Office Policy on Project Management in Support of DOE Order 430.1; Program and Project Management for the Acquisition of Capital Assets, DOE Order 413.3; the Project Execution and Engineering Management Planning Guide, GPG-FM-010; and other applicable Good Practice Guides; and the FY 2001 Integrated Planning, Accountability, and Budgeting System Policy Guidance. The plan also reflects the milestone philosophies of the Federal Facility Agreement and Consent Order, as agreed to by the State of Nevada, the DOE, and the U.S. Department of Defense; and traditional project management philosophies such as the development of life-cycle costs, schedules, and work scope; identification o f roles and responsibilities; and baseline management and controls

Pediatric uroradiology. 2nd rev. ed.

International Nuclear Information System (INIS)

Fotter, Richard

2008-01-01

Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle ''guidelines and beyond,'' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

Pediatric uroradiology. 2nd rev. ed.

Energy Technology Data Exchange (ETDEWEB)

Fotter, Richard (ed.) [Univ. Hospital Medical Univ. Graz (Austria). Div. of Pediatric Radiology

2008-07-01

Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle 'guidelines and beyond,' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

Biological fundamentals. 2. completely rev. ed

Energy Technology Data Exchange (ETDEWEB)

Sahm, H. (ed.) (Forschungszentrum Juelich GmbH (Germany). Inst. fuer Biotechnologie)

1993-01-01

This fully revised and expanded Second Edition takes into account all recent developments in biotechnology. It is extraordinarily broad in scope, up-to-date, carefully structured and wellbalanced. 'Biotechnology' considers both basic concepts and widely-differing industrial applications: It is a successful synthesis of theory and practice. Any scientist aiming for success in industrial microbiology, biochemistry, molecular biology and chemical engineering must turn to 'Biotechnology'. Everybody involved in biotechnology will appreciate having this volume at their fingertips. It offers a unique collection of current information on the basic biology (ecology, taxonomy, biochemistry, physiology, and genetics) of industrially important organisms. This book contains the background material indispensable for the development of biotechnological processes. Topics included are: - Cell Structure, - Metabolism, - Growth of Microorganisms, - Metabolic Design, - Immobilized Organisms, - Methylotrophs, - Pseudomonas, - Yeasts, - Filamentous Fungi, - Bacteriophages, - Cell Cultures. (orig.)

Technical fluid dynamics. 7. rev. ed.

International Nuclear Information System (INIS)

Becker, E.; Piltz, E.

1993-01-01

An introductory textbook for students of engineering containing the following subjects: Definition and properties of fluids, hydrostatics, Bernoulli's equation, theorem of momentum for steadystate flows, wing lattice and single wing, plane parallel flow of a viscous fluid, pipe flow, boundary layers, gas flows. (orig.) [de

Radioactivity: Risks - safety. 2. rev. ed.

International Nuclear Information System (INIS)

Grupe, H.

1991-01-01

This revised and updated version of the report first published in 1987 by Karlsruhe Nuclear Center has been prepared by scientists of the Center who are experts in nuclear science and technology. The idea was to fulfill the so-to-speak ''creditor's'' obligation in the public debate about nuclear energy and its hazards, and to provide the general public not so familiar with the subject matter with information and insight for better understanding, hoping that the general public on their part will fulfill their ''debtor's'' obligation by trying to get properly informed. Chapters 1 and 6 of the report have been revised and brought up to date, while chapter 3 has been fully re-written, taking as a main source of reference the 1989 publication of Phase B of the German Risk Study on nuclear power plant. Chapters 2 and 5 are new in this report, dealing with less broadly known applications of radioactive substances in science, medicine and technology, and with the radiological situation in Germany after the Chernobyl reactor accident. (orig./DG) [de

Techniques of lipidology. 2. rev. ed.

International Nuclear Information System (INIS)

Kates, M.

1986-01-01

In this volume basic knowledge and the most reliable and useful methods and experimental procedures are collected for the study of the chemistry and metabolism of lipids. The material presented covers information necessary for the qualitative and quantitative analysis of cellular or tissue lipids, and for identification and structural determination of lipid classes or individual components. (Auth.)

GGVS. 7. rev. and enlarged ed.

International Nuclear Information System (INIS)

Ridder, K.

1991-01-01

The brochure contains the following texts: (1) Ordinance on road transport of hazardous materials (GGVS), including the European agreement on international road transport of hazardous materials (ADR), as of 1991: Skeleton ordinance, annexes A and B, reasons given for the first version, and for the first amendment in 1988, execution guidelines - RS 002 (guidelines for executing the ordinance on road transport of hazardous materials, with catalogue of penalties), guidelines for drawing up written instructions for the event of accidents - RS 006, guiding principles for the training of vehicle conductors; (2) ordinance regarding exceptions from the ordinance on road transport of hazardous materials; (3) ordinance regarding exceptions from the ordinance on rail transport of hazardous materials; (4) selected guidelines: Technical guidelines TR IBC K 001, TR IBL 002 - TRS 003, - TRS 004, - TRS 005, - TRS 006; (5) listing of materials and objects governed by the ordinance on hazardous materials transport; (6) catalogue of penalties relative to road transport of hazardous materials. (orig.) [de

Radiation monitoring: an introduction. Rev. ed.

International Nuclear Information System (INIS)

Hayward, P.; Arnott, D.

1987-01-01

This Greenpeace pamphlet has been produced in reponse to requests from members of the public wishing to set up monitoring groups. It lists some U.K. manufacturers of radiation monitoring equipment and the contributors have summarized information available from manufacturer's own catalogues describing the equipment, what it will and will not do and costing various programmes. Three types of monitoring are discussed: monitoring the level of background gamma radiation, monitoring radioactive contamination, (early warning systems), and monitoring food and environmental samples for very low levels of radiation. (UK)

Elastic fields, dipole tensors, and interaction between self-interstitial atom defects in bcc transition metals

Science.gov (United States)

Dudarev, S. L.; Ma, Pui-Wai

2018-03-01

Density functional theory (DFT) calculations show that self-interstitial atom (SIA) defects in nonmagnetic body-centered-cubic (bcc) metals adopt strongly anisotropic configurations, elongated in the direction [S. Han et al., Phys. Rev. B 66, 220101 (2002), 10.1103/PhysRevB.66.220101; D. Nguyen-Manh et al., Phys. Rev. B 73, 020101 (2006), 10.1103/PhysRevB.73.020101; P. M. Derlet et al., Phys. Rev. B 76, 054107 (2007), 10.1103/PhysRevB.76.054107; S. L. Dudarev, Annu. Rev. Mater. Res. 43, 35 (2013), 10.1146/annurev-matsci-071312-121626]. Elastic distortions, associated with such anisotropic atomic structures, appear similar to distortions around small prismatic dislocation loops, although the extent of this similarity has never been quantified. We derive analytical formulas for the dipole tensors of SIA defects, which show that, in addition to the prismatic dislocation looplike character, the elastic field of a SIA defect also has a significant isotropic dilatation component. Using empirical potentials and DFT calculations, we parametrize dipole tensors of defects for all the nonmagnetic bcc transition metals. This enables a quantitative evaluation of the energy of elastic interaction between the defects, which also shows that in a periodic three-dimensional simple cubic arrangement of crowdions, long-range elastic interactions between a defect and all its images favor a orientation of the defect.

Electronic structures of the F-terminated AlN nanoribbons

Indian Academy of Sciences (India)

2012-03-05

Mar 5, 2012 ... Province Education Department Natural Science Research Project, China (Grant No. 2011B510014). References. [1] L Brey and H A Fertig, Phys. Rev. B73, 235411 (2006). [2] Y W Son, M L Cohen and S G Louie, Phys. Rev. Lett. 97, 216803 (2006). [3] D A Abanin, P A Lee and L S Levitov, Phys. Rev. Lett.

Joint Services Electronics Program.

Science.gov (United States)

1986-09-30

and W.E. Lamb , Jr., Phys. Rev. 181, 618 (1969); B.J. Feldman and M.S. Feld, Phys. Rev. Al, 1375 (-970); J.H. Shirley, Phys. Rev. A8, 347 (1973); V.S...Dr. Leo Young Mr. Ball Chin Office of the Deputy Under Secretary White Sands Missile Range of Defense for Research and ATTN: STEWS -ID-E Engineering (R

On the dual symmetry between absorbing and amplifying random ...

Indian Academy of Sciences (India)

(Paris), 48, 527 (1987). [20] C Vanneste and P Sebbah, Phys. Rev. Lett. 87, 183903 (2001). P Sebbah and C Vanneste, Phys. Rev. B66, 144202 (2002). [21] X Jiang and C M Soukoulis, Phys. Rev. Lett. 85, 70 (2000). [22] M Ya Azbel, Solid State Commun. 45, 527 (1983). [23] J B Pendry, A Mackinnon and P J Roberts, Proc.

Dynamical properties of moving atom–atom entanglement and ...

Indian Academy of Sciences (India)

[24] F A A El-Orany, Phys. Scr. 74, 563 (2006). [25] K Berrada, F F Fanchini and S Abdel-Khalek, Phys. Rev. A 85, 052315 (2012). [26] S Abdel-Khalek, S h Barazanjeh and H Eleuch, Int. J. Theor. Phys. 50, 2939 (2011). [27] W K Wootters, Phys. Rev. Lett. 80, 2245 (1998). [28] A Peres, Phys. Rev. Lett. 77, 1413 (1996).

Dicty_cDB: Contig-U14801-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available CAZO Naegleria gruberi Flagellate Sta... 42 1.1 2 ( FD681213 ) CBHW4480.rev CBHW Mycosphaerella fiji...ensis MfEST4... 46 1.9 1 ( FD669540 ) CBHT4023.rev CBHT Mycosphaerella fijiensis MfEST3...... 46 1.9 1 ( FD669082 ) CBHT3400.rev CBHT Mycosphaerella fijiensis MfEST3... 46 1.9 1 ( AE017194 ) Bacillus

The Role of Stat3 Activation in Androgen Receptor Signaling and Prostate Cancer

Science.gov (United States)

2006-07-01

S. C. & Xiao, G. (2003) Cancer Metastasis Rev. 22, 405–422. 10. Karin, M. & Greten , F. R. (2005) Nat. Rev. Immunol. 5, 749–759. 11. Karin, M., Cao, Y... Greten , F. R. & Li, Z. W. (2002) Nat. Rev. Cancer 2, 301–310. 12. Fan, C. M. & Maniatis, T. (1991) Nature 354, 395–398. 13. Betts, J. C. & Nabel, G

530 Saroj K Nayak and Ramakrishna Ramaswamy

Indian Academy of Sciences (India)

Catlow C R A Parker SC and Allen M P 1990 Computer Modeling of fluids, polymers and Solids (Kluwer. Academic Publishers). Dhar D 1990 Phys. Rev. Lett. 64 1613. Dhar D and Ramaswamy R 1989 Phys. Rev. Lett. 63 1659. Dutta P and Horn P M 1981 Rev. Mod. Phys. 53 497. Frank H S and Wen WY 1987 Discuss, ...

Resveratrol Protects Against Pulmonary Arterial Hypertension in Rats via Activation of Silent Information Regulator 1

Directory of Open Access Journals (Sweden)

Lei Yu

2017-05-01

Full Text Available Background/Objectives: The polyphenol resveratrol (Rev has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH. The present study was designed to investigate the action and potential mechanism of Rev on PAH, focusing on the role of SIRT1 (Silent Information Regulator 1 in apoptosis of pulmonary artery smooth muscle cells (PASMCs. Methods: PAH rats were established by exposure to hypoxia for 21 days. Rev and SRT1720 (a selective SIRT1 activator were used to reverse PAH by gavaging rats. PASMCs were confronted with hypoxia for 24 h or 48 h and were then treated with Rev or SRT1720 in vitro. Western blot was performed to detect the protein expression of SIRT1. CCK-8 and scratch wound experiments were carried out to verify cell proliferation. In addition, the TUNEL positive assay and flow cytometry assay were used to measure PASMC apoptosis. Mitochondrial permeability transition (mPT was identified by confocal microscopy. Right ventricular systolic pressure (RVSP was determined with a Gould pressure transducer, and right ventricular hypertrophy (RVH was determined by weighing the cardiac muscle. Results: We demonstrated that Rev could reverse the remodelling of the pulmonary vasculature, thus contributing to alleviating the severity of PAH. Down-regulation of SIRT1 was observed in PAH, but administration of Rev had no obvious effect on the protein expression of SIRT1. In addition, Rev could induce mitochondrial swelling and nuclear pyknosis, leading to small, dense, and dysmorphic mitochondria in rats exposed to hypoxia alone. Rev treatment inhibited PASMC proliferation in a dose-dependent manner in vitro. Incubation with SRT1720, a specific activator of SIRT1, significantly retarded PASMC proliferation and promoted PASMC apoptosis in vitro. The mechanism could be associated with inducing mPT damage in PASMCs. Rev and SRT1720 treatment mitigated RVSP and reduced RVH. Conclusion: Rev produced

The dipteran family Celyphidae in the New World, with discussion of and key to world genera (Insecta, Diptera

Directory of Open Access Journals (Sweden)

Stephen D. Gaimari

2017-10-01

Full Text Available The family Celyphidae (Diptera, Lauxanioidea is verified as part of the New World fauna, with a second specimen discovered of a species described from French Guiana in 1844 by P.J.M. Macquart. As this species possesses characteristics that clearly suggest a separate lineage from the Old World celyphids, a new genus is proposed, Atopocelyphus gen. n., with the type species, Celyphus ruficollis Macquart, in the new combination Atopocelyphus ruficollis (Macquart, comb. n. A key to world genera of Celyphidae is presented, along with discussion of generic concepts. Chamaecelyphus Frey is synonymized under Spaniocelyphus Hendel, syn. n., resulting in the following 10 new combinations: Spaniocelyphus africanus (Walker, comb. n.; S. dichrous (Bezzi, comb. n.; S. gutta (Speiser, comb. n.; S. halticinus (Frey, comb. n.; S. kalongensis (Vanschuytbroek, comb. n.; S. ruwenzoriensis (Vanschuytbroek, comb. n.; S. straeleni (Vanschuytbroek, comb. n.; S. upembaensis (Vanschuytbroek, comb. n.; S. violaceus (Vanschuytbroek, comb. n.; S. vrydaghi (Vanschuytbroek, comb. n. The subgenera of Celyphus Dalman are elevated to genus rank, as Paracelyphus Bigot, stat. rev., and Hemiglobus Frey, stat. rev., resulting in the following 17 new and revised combinations: Hemiglobus cheni (Shi, comb. n.; H. eos (Frey, comb. n.; H. lacunosus Frey, comb. rev.; H. pellucidus Frey, comb. rev.; H. planitarsalis (Shi, comb. n.; H. porosus (Tenorio, comb. n.; H. pulchmaculatus (Liu & Yang, comb. n.; H. quadrimaculatus (Tenorio, comb. n.; H. resplendens Frey, comb. rev.; H. rugosus (Tenorio, comb. n.; H. testaceus (Malloch, comb. n.; H. trichoporis (Shi, comb. n.; H. unicolor Frey, comb. rev.; H. violaceus Chen, comb. rev.; Paracelyphus hyacinthus Bigot, comb. rev.; P. medogis (Shi, comb. n.; P. vittalis (Shi, comb. n.

Development and Characterization of Boehmite Component Simulant

Energy Technology Data Exchange (ETDEWEB)

Russell, Renee L.; Peterson, Reid A.; Smith, Harry D.; Rinehart, Donald E.; Aker, Pamela M.; Buck, Edgar C.

2009-06-03

According to Bechtel National Inc.’s (BNI’s) Test Specification 24590-PTF-TSP-RT-06-006, Rev 0, “Simulant Development to Support the Development and Demonstration of Leaching and Ultrafiltration Pretreatment Processes,” simulants for boehmite, gibbsite, and filtration are to be developed that can be used in subsequent bench and integrated testing of the leaching/filtration processes. These simulants will then be used to demonstrate the leaching process and to help refine processing conditions that may impact safety basis considerations (Smith 2006). This report documents the results of the boehmite simulant development and blended simulant crossflow ultrafiltration leaching completed in accordance with the test plan TP-RPP-WTP-469 Rev 0 (WTP Doc. No. 24590- 101-TSA-W000-0004-182-00001 Rev 00A) prepared and approved in response to the cited test specification. This report also includes the results of the aluminate and anion effect on boehmite dissolution performed in accordance with the test plan TP-RPP-WTP-509, Rev 0 (WTP Doc. No. 24590-101-TSA-W000-0004-72-00019 Rev 00A) prepared and approved in response to the Test Specification 24590-WTP-TSP-RT-07-004, Rev 0 (Sundar 2007).

Kinetic Basis of Nucleotide Selection Employed by a Protein Template-Dependent DNA Polymerase†

Science.gov (United States)

Brown, Jessica A.; Fowler, Jason D.; Suo, Zucai

2010-01-01

Rev1, a Y-family DNA polymerase, contributes to spontaneous and DNA damage-induced mutagenic events. In this paper, we have employed pre-steady state kinetic methodology to establish a kinetic basis for nucleotide selection by human Rev1, a unique nucleotidyl transferase that uses a protein template-directed mechanism to preferentially instruct dCTP incorporation. This work demonstrated that the high incorporation efficiency of dCTP is dependent on both substrates: an incoming dCTP and a templating base dG. The extremely low base substitution fidelity of human Rev1 (100 to 10-5) was due to the preferred misincorporation of dCTP with templating bases dA, dT, and dC over correct dNTPs. Using non-natural nucleotide analogs, we showed that hydrogen bonding interactions between residue R357 of human Rev1 and an incoming dNTP are not essential for DNA synthesis. Lastly, human Rev1 discriminates between ribonucleotides and deoxyribonucleotides mainly by reducing the rate of incorporation, and the sugar selectivity of human Rev1 is sensitive to both the size and orientation of the 2′-substituent of a ribonucleotide. PMID:20518555

Intragenic HIV-1 env sequences that enhance gag expression

International Nuclear Information System (INIS)

Suptawiwat, Ornpreya; Sutthent, Ruengpung; Lee, T.-H.; Auewarakul, Prasert

2003-01-01

Expression of HIV-1 genes is regulated at multiple levels including the complex RNA splicing and transport mechanisms. Multiple cis-acting elements involved in these regulations have been previously identified in various regions of HIV-1 genome. Here we show that another cis-acting element was present in HIV-1 env region. This element enhanced the expression of Gag when inserted together with Rev response element (RRE) into a truncated HIV-1 genome in the presence of Rev. The enhancing activity was mapped to a 263-bp fragment in the gp41 region downstream to RRE. RNA analysis showed that it might function by promoting RNA stability and Rev-dependent RNA export. The enhancement was specific to Rev-dependent expression, since it did not enhance Gag expression driven by Sam68, a cellular protein that has been shown to be able to substitute for Rev in RNA export function

Comment on "Modified quantum-speed-limit bounds for open quantum dynamics in quantum channels"

Science.gov (United States)

Mirkin, Nicolás; Toscano, Fabricio; Wisniacki, Diego A.

2018-04-01

In a recent paper [Phys. Rev. A 95, 052118 (2017), 10.1103/PhysRevA.95.052118], the authors claim that our criticism, in Phys. Rev. A 94, 052125 (2016), 10.1103/PhysRevA.94.052125, to some quantum speed limit bounds for open quantum dynamics that appeared recently in literature are invalid. According to the authors, the problem with our analysis would be generated by an artifact of the finite-precision numerical calculations. We analytically show here that it is not possible to have any inconsistency associated with the numerical precision of calculations. Therefore, our criticism of the quantum speed limit bounds continues to be valid.

Dicty_cDB: Contig-U16149-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available se ... 42 6e-05 4 ( FE846919 ) CAFI987.rev CAFI Pichia stipitis aerobic dextrose... 42 7e-05 4 ( FE859704 ) ...CAFY1016.rev CAFY Pichia stipitis oxygen limited ... 42 7e-05 4 ( FE846736 ) CAFI892.rev CAFI Pichia stipitis aerobic dextrose... stipitis oxygen limited ... 42 7e-05 4 ( FE846737 ) CAFI892.fwd CAFI Pichia stipitis aerobic dextrose... 42...AFY Pichia stipitis oxygen limited x... 42 7e-05 4 ( FE845859 ) CAFI425.fwd CAFI Pichia stipitis aerobic dextrose...... 42 7e-05 4 ( FE845858 ) CAFI425.rev CAFI Pichia stipitis aerobic dextrose... 42 8e-05 4 ( FE852579

Comment on "Generalization of the Kohn-Sham system that can represent arbitrary one-electron density matrices"

Science.gov (United States)

Piris, Mario; Pernal, Katarzyna

2017-10-01

van Dam [Phys. Rev. A 93, 052512 (2016), 10.1103/PhysRevA.93.052512] claims that the one-particle reduced density matrix (1RDM) of an interacting system can be represented by means of a single-determinant wave function of fictitious noninteracting particles. van Dam [Phys. Rev. A 93, 052512 (2016), 10.1103/PhysRevA.93.052512] introduced orbitals within a mean-field framework that produce energy levels similar to Hartree-Fock orbital energies, therefore he also claims that conventional analyses based on Koopmans' theorem are possible in 1RDM functional theory. In this Comment, we demonstrate that both claims are unfounded.

Palladium complexes of pyrrole-2-aldehyde thiosemicarbazone ...

Indian Academy of Sciences (India)

Chem. Rev. 253 1384; (j) Lobana T S, Sharma. R, Bawa G and Khanna S 2009 Coord. Chem. Rev. 253. 977; (k) Quiroga A G and Ranninger C N 2004 Coord. Chem. Rev. 248 119; (l) Dilworth J R, Arnold P, Morales. D, Wong Y L and Zheng Y 2002 Modern Coord. Chem. 217; (m) West D X, Liberta A E, Padhye S B, Chikate.

Wigner function and Schroedinger equation in phase-space representation

International Nuclear Information System (INIS)

Chruscinski, Dariusz; Mlodawski, Krzysztof

2005-01-01

We discuss a family of quasidistributions (s-ordered Wigner functions of Agarwal and Wolf [Phys. Rev. D 2, 2161 (1970); Phys. Rev. D 2, 2187 (1970); Phys. Rev. D 2, 2206 (1970)]) and its connection to the so-called phase space representation of the Schroedinger equation. It turns out that although Wigner functions satisfy the Schroedinger equation in phase space, they have a completely different interpretation

Untitled

Indian Academy of Sciences (India)

Proc. Nat. Acad. Sci., U.S.A., 1929, 15, 896. 5. D. N. Read & sº ... Phys. Rev., 1934, 46, 571. 6. D. Coster and F. Brons ... Physica, 1934, 1, 155; Nature, 1934, 133, 140. 7. W. W. Watson ... ... Phys. Rev., 1932, 42, 509. -. 8. R. de L. Kronig .. . . Zs. f. Physik, 1928, 50, 347. 9. J. Kaplan * * ... Phys. Rev., 1930, 36, 788. 10. L. Gerő .

Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis

Science.gov (United States)

Arbel-Eden, Ayelet; Joseph-Strauss, Daphna; Masika, Hagit; Printzental, Oxana; Rachi, Eléanor; Simchen, Giora

2013-01-01

Trans-lesion DNA polymerases (TLSPs) enable bypass of DNA lesions during replication and are also induced under stress conditions. Being only weakly dependent on their template during replication, TLSPs introduce mutations into DNA. The low processivity of these enzymes ensures that they fall off their template after a few bases are synthesized and are then replaced by the more accurate replicative polymerase. We find that the three TLSPs of budding yeast Saccharomyces cerevisiae Rev1, PolZeta (Rev3 and Rev7), and Rad30 are induced during meiosis at a time when DNA double-strand breaks (DSBs) are formed and homologous chromosomes recombine. Strains deleted for one or any combination of the three TLSPs undergo normal meiosis. However, in the triple-deletion mutant, there is a reduction in both allelic and ectopic recombination. We suggest that trans-lesion polymerases are involved in the processing of meiotic double-strand breaks that lead to mutations. In support of this notion, we report significant yeast two-hybrid (Y2H) associations in meiosis-arrested cells between the TLSPs and DSB proteins Rev1-Spo11, Rev1-Mei4, and Rev7-Rec114, as well as between Rev1 and Rad30. We suggest that the involvement of TLSPs in processing of meiotic DSBs could be responsible for the considerably higher frequency of mutations reported during meiosis compared with that found in mitotically dividing cells, and therefore may contribute to faster evolutionary divergence than previously assumed. PMID:23550131

Simulation of DNAPL migration in heterogeneous translucent porous media based on estimation of representative elementary volume

Science.gov (United States)

Wu, Ming; Wu, Jianfeng; Wu, Jichun

2017-10-01

When the dense nonaqueous phase liquid (DNAPL) comes into the subsurface environment, its migration behavior is crucially affected by the permeability and entry pressure of subsurface porous media. A prerequisite for accurately simulating DNAPL migration in aquifers is then the determination of the permeability, entry pressure and corresponding representative elementary volumes (REV) of porous media. However, the permeability, entry pressure and corresponding representative elementary volumes (REV) are hard to determine clearly. This study utilizes the light transmission micro-tomography (LTM) method to determine the permeability and entry pressure of two dimensional (2D) translucent porous media and integrates the LTM with a criterion of relative gradient error to quantify the corresponding REV of porous media. As a result, the DNAPL migration in porous media might be accurately simulated by discretizing the model at the REV dimension. To validate the quantification methods, an experiment of perchloroethylene (PCE) migration is conducted in a two-dimensional heterogeneous bench-scale aquifer cell. Based on the quantifications of permeability, entry pressure and REV scales of 2D porous media determined by the LTM and relative gradient error, different models with different sizes of discretization grid are used to simulate the PCE migration. It is shown that the model based on REV size agrees well with the experimental results over the entire migration period including calibration, verification and validation processes. This helps to better understand the microstructures of porous media and achieve accurately simulating DNAPL migration in aquifers based on the REV estimation.

A quasi-lentiviral green fluorescent protein reporter exhibits nuclear export features of late human immunodeficiency virus type 1 transcripts

International Nuclear Information System (INIS)

Graf, Marcus; Ludwig, Christine; Kehlenbeck, Sylvia; Jungert, Kerstin; Wagner, Ralf

2006-01-01

We have previously shown that Rev-dependent expression of HIV-1 Gag from CMV immediate early promoter critically depends on the AU-rich codon bias of the gag gene. Here, we demonstrate that adaptation of the green fluorescent protein (GFP) reporter gene to HIV codon bias is sufficient to turn this hivGFP RNA into a quasi-lentiviral message following the rules of late lentiviral gene expression. Accordingly, GFP expression was significantly decreased in transfected cells strictly correlating with reduced RNA levels. In the presence of the HIV 5' major splice donor, the hivGFP RNAs were stabilized in the nucleus and efficiently exported to the cytoplasm following fusion of the 3' Rev-responsive element (RRE) and coexpression of HIV-1 Rev. This Rev-dependent translocation was specifically inhibited by leptomycin B suggesting export via the CRM1-dependent pathway used by late lentiviral transcripts. In conclusion, this quasi-lentiviral reporter system may provide a new platform for developing sensitive Rev screening assays

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA.

Science.gov (United States)

Booth, David S; Cheng, Yifan; Frankel, Alan D

2014-12-08

The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions. The RRE assembles a Rev oligomer that displays nuclear export sequences (NESs) for recognition by the Crm1-Ran(GTP) nuclear receptor complex. Here we provide the first view of an assembled HIV-host nuclear export complex using single-particle electron microscopy. Unexpectedly, Crm1 forms a dimer with an extensive interface that enhances association with Rev-RRE and poises NES binding sites to interact with a Rev oligomer. The interface between Crm1 monomers explains differences between Crm1 orthologs that alter nuclear export and determine cellular tropism for viral replication. The arrangement of the export complex identifies a novel binding surface to possibly target an HIV inhibitor and may point to a broader role for Crm1 dimerization in regulating host gene expression.

Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo

International Nuclear Information System (INIS)

Muthumani, Karuppiah; Zhang Donghui; Dayes, Nathanael S.; Hwang, Daniel S.; Calarota, Sandra A.; Choo, Andrew Y.; Boyer, Jean D.; Weiner, David B.

2003-01-01

HIV-1 sequences are highly diverse due to the inaccuracy of the viral reverse transcriptase. This diversity has been studied and used to categorize HIV isolates into subtypes or clades, which are geographically distinct. To develop effective vaccines against HIV-1, immunogens representing different subtypes may be important for induction of cross-protective immunity, but little data exist describing and comparing the immunogenicity induced by different subtype-based vaccines. This issue is further complicated by poor expression of HIV structural antigens due to rev dependence. One costly approach is to codon optimize each subtype construct to be examined. Interestingly, cis-acting transcriptional elements (CTE) can also by pass rev restriction by a rev independent export pathway. We reasoned that rev+CTE constructs might have advantages for such expression studies. A subtype A envelope sequence from a viral isolate from east Africa was cloned into a eukaryotic expression vector under the control of the CMV-IE promoter. The utility of inclusion of the Mason-Pfizer monkey virus (MPV)-CTE with/without rev for driving envelope expression and immunogenicity was examined. Expression of envelope (gp120) was confirmed by immunoblot analysis and by pseudotype virus infectivity assays. The presence of rev and the CTE together increased envelope expression and viral infection. Furthermore the CTE+rev construct was significantly more immunogenic then CTE alone vector. Isotype analysis and cytokine profiles showed strong Th1 response in plasmid-immunized mice, which also demonstrated the superior nature of the rev+CTE construct. These responses were of similar or greater magnitude to a codon-optimized construct. The resulting cellular immune responses were highly cross-reactive with a HIV-1 envelope subtype B antigen. This study suggests a simple strategy for improving the expression and immunogenicity of HIV subtype-specific envelope antigens as plasmid or vector

ارزیابی پروسه پایداری واکسن بروسلا ملی تنسیس Rev.1درایران

Directory of Open Access Journals (Sweden)

ا. پوراحمدی

2009-07-01

Full Text Available واکسن Rev.1 از جمله بهترین و با ارزش‌ترین واکسن‌های موجود برای پیشگیری و کنترل بروسلوز گوسفند و بز می‌باشد که توسط سازمان‌های معتبر بین‌المللی از جمله WHOو OIE و FAO به رسمیت شناخته شده است. مؤثر بودن این واکسن توسط محققین کشور و با همکاری سازمان بهداشت جهانی در شرایط اقلیمی ایران بر روی نژادهای گوسفند و بز ایرانی به اثبات رسیده است. بطوریکه از سال 1341 که تولید واکسن و واکسیناسیون Rev.1 در کشور آغاز شده, میزان شیوع بیماری از میزان 45% به 8/1% تقلیل یافته است. طبق منابع رسمی WHO پایداری واکسن Rev.1بیش از یکسال می‌باشد، در حالیکه تاریخ انقضاء واکسنهای تولیدی Rev.1 کشور سه الی چهار ماه است، لذا افزایش زمان پایداری واکسن می‌تواند بسیاری از مشکلات بخش تولید را حل کند و درخواست سازمان دامپزشکی که افزایش مدت نگهداری واکسن است، پاسخ مثبت دهد. این مطالعه با شاخص قرار دادن و ارزیابی ماده نگهدارنده و روش لیوفیلیزاسیون افزایش مدت نگهداری واکسن بود. نوع ماده نگهدارنده در دو حجم متفاوت و همچنین سه روش مختلف لیوفیلیزاسیون که در افزایش زمان نگهداری موثر بود، تهیه و مورد ارزیابی قرار گرفت. از یافته‌های این تحقیق آنکه بهترین ترکیب ماده نگهدارنده برای واکسن Rev.1 شامل : باکتوکازیتون 5/2%، ساکارز 5% و ال گلوتامیک اسید 5

Dicty_cDB: Contig-U12496-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available E8.r CHORI-242 Sus scrofa genomic clone C... 44 9.1 1 ( FD687842 ) CBHY1281.fwd CBHY Mycosphaerella fijiensi...s MfEST5... 44 9.1 1 ( FD687633 ) CBHY1157.rev CBHY Mycosphaerella fijiensis MfEST5... 44 9.1 1 ( FD687295 )... CBHX6118.fwd CBHX Mycosphaerella fijiensis MfEST4... 44 9.1 1 ( FD682112 ) CBHX1...985.rev CBHX Mycosphaerella fijiensis MfEST4... 44 9.1 1 ( FD677743 ) CBHW1795.rev CBHW Mycosphaerella fijie...nsis MfEST4... 44 9.1 1 ( FD666344 ) CBHT1283.rev CBHT Mycosphaerella fijiensis MfEST3... 44 9.1 1 >( AC1155

Analytical results for a conditional phase shift between single-photon pulses in a nonlocal nonlinear medium

Science.gov (United States)

Viswanathan, Balakrishnan; Gea-Banacloche, Julio

2018-03-01

It has been suggested that second-order nonlinearities could be used for quantum logic at the single-photon level. Specifically, successive two-photon processes in principle could accomplish the phase shift (conditioned on the presence of two photons in the low-frequency modes) |011 〉→i |100 〉→-|011 〉 . We have analyzed a recent scheme proposed by Xia et al. [Phys. Rev. Lett. 116, 023601 (2016)], 10.1103/PhysRevLett.116.023601 to induce such a conditional phase shift between two single-photon pulses propagating at different speeds through a nonlinear medium with a nonlocal response. We present here an analytical solution for the most general case, i.e., for an arbitrary response function, initial state, and pulse velocity, which supports their numerical observation that a π phase shift with unit fidelity is possible, in principle, in an appropriate limit. We also discuss why this is possible in this system, despite the theoretical objections to the possibility of conditional phase shifts on single photons that were raised some time ago by Shapiro [Phys. Rev. A 73, 062305 (2006)], 10.1103/PhysRevA.73.062305 and by Gea-Banacloche [Phys. Rev. A 81, 043823 (2010)], 10.1103/PhysRevA.81.043823 one of us.

Dirac Magnons in Honeycomb Ferromagnets

Directory of Open Access Journals (Sweden)

Sergey S. Pershoguba

2018-01-01

Full Text Available The discovery of the Dirac electron dispersion in graphene [A. H. Castro Neto, et al., The Electronic Properties of Graphene, Rev. Mod. Phys. 81, 109 (2009RMPHAT0034-686110.1103/RevModPhys.81.109] led to the question of the Dirac cone stability with respect to interactions. Coulomb interactions between electrons were shown to induce a logarithmic renormalization of the Dirac dispersion. With a rapid expansion of the list of compounds and quasiparticle bands with linear band touching [T. O. Wehling, et al., Dirac Materials, Adv. Phys. 63, 1 (2014ADPHAH0001-873210.1080/00018732.2014.927109], the concept of bosonic Dirac materials has emerged. We consider a specific case of ferromagnets consisting of van der Waals-bonded stacks of honeycomb layers, e.g., chromium trihalides CrX_{3} (X=F, Cl, Br and I, that display two spin wave modes with energy dispersion similar to that for the electrons in graphene. At the single-particle level, these materials resemble their fermionic counterparts. However, how different particle statistics and interactions affect the stability of Dirac cones has yet to be determined. To address the role of interacting Dirac magnons, we expand the theory of ferromagnets beyond the standard Dyson theory [F. J. Dyson, General Theory of Spin-Wave Interactions, Phys. Rev. 102, 1217 (1956PHRVAO0031-899X10.1103/PhysRev.102.1217, F. J. Dyson, Thermodynamic Behavior of an Ideal Ferromagnet, Phys. Rev. 102, 1230 (1956PHRVAO0031-899X10.1103/PhysRev.102.1230] to the case of non-Bravais honeycomb layers. We demonstrate that magnon-magnon interactions lead to a significant momentum-dependent renormalization of the bare band structure in addition to strongly momentum-dependent magnon lifetimes. We show that our theory qualitatively accounts for hitherto unexplained anomalies in nearly half-century-old magnetic neutron-scattering data for CrBr_{3} [W. B. Yelon and R. Silberglitt, Renormalization of Large-Wave-Vector Magnons in

Dirac Magnons in Honeycomb Ferromagnets

Science.gov (United States)

Pershoguba, Sergey S.; Banerjee, Saikat; Lashley, J. C.; Park, Jihwey; Ågren, Hans; Aeppli, Gabriel; Balatsky, Alexander V.

2018-01-01

The discovery of the Dirac electron dispersion in graphene [A. H. Castro Neto, et al., The Electronic Properties of Graphene, Rev. Mod. Phys. 81, 109 (2009), 10.1103/RevModPhys.81.109] led to the question of the Dirac cone stability with respect to interactions. Coulomb interactions between electrons were shown to induce a logarithmic renormalization of the Dirac dispersion. With a rapid expansion of the list of compounds and quasiparticle bands with linear band touching [T. O. Wehling, et al., Dirac Materials, Adv. Phys. 63, 1 (2014), 10.1080/00018732.2014.927109], the concept of bosonic Dirac materials has emerged. We consider a specific case of ferromagnets consisting of van der Waals-bonded stacks of honeycomb layers, e.g., chromium trihalides CrX3 (X =F , Cl, Br and I), that display two spin wave modes with energy dispersion similar to that for the electrons in graphene. At the single-particle level, these materials resemble their fermionic counterparts. However, how different particle statistics and interactions affect the stability of Dirac cones has yet to be determined. To address the role of interacting Dirac magnons, we expand the theory of ferromagnets beyond the standard Dyson theory [F. J. Dyson, General Theory of Spin-Wave Interactions, Phys. Rev. 102, 1217 (1956), 10.1103/PhysRev.102.1217, F. J. Dyson, Thermodynamic Behavior of an Ideal Ferromagnet, Phys. Rev. 102, 1230 (1956), 10.1103/PhysRev.102.1230] to the case of non-Bravais honeycomb layers. We demonstrate that magnon-magnon interactions lead to a significant momentum-dependent renormalization of the bare band structure in addition to strongly momentum-dependent magnon lifetimes. We show that our theory qualitatively accounts for hitherto unexplained anomalies in nearly half-century-old magnetic neutron-scattering data for CrBr3 [W. B. Yelon and R. Silberglitt, Renormalization of Large-Wave-Vector Magnons in Ferromagnetic CrBr3 Studied by Inelastic Neutron Scattering: Spin-Wave Correlation

Experimental Plan for EDF Energy Creep Rabbit Graphite Irradiations- Rev. 2 (replaces Rev. 0 ORNL/TM/2013/49).

Energy Technology Data Exchange (ETDEWEB)

Burchell, Timothy D [ORNL

2014-07-01

The experimental results obtained here will assist in the development and validation of future models of irradiation induced creep of graphite by providing the following data: Inert creep stain data from low to lifetime AGR fluence Inert creep-property data (especially CTE) from low to lifetime AGR fluence Effect of oxidation on creep modulus (by indirect comparison with experiment 1 and direct comparison with experiment 3 NB. Experiment 1 and 3 are not covered here) Data to develop a mechanistic understanding, including oAppropriate creep modulus (including pinning and high dose effects on structure) oInvestigation of CTE-creep strain behavior under inert conditions oInformation on the effect of applied stress/creep strain on crystallite orientation (requires XRD) oEffect of creep strain on micro-porosity (requires tomography & microscopy) This document describes the experimental work planned to meet the requirements of project technical specification [1] and EDF Energy requests for additional Pre-IE work. The PIE work is described in detail in this revision (Section 8 and 9).

Scaling and universality of ac conduction in disordered solids

DEFF Research Database (Denmark)

Schrøder, Thomas; Dyre, Jeppe

2000-01-01

Recent scaling results for the ac conductivity of ionic glasses by Roling et al. [Phys. Rev. Lett. 78, 2160 (1997)] and Sidebottom [Phys. Rev. Lett. 82, 3653 (1999)] are discussed. We prove that Sidebottom's version of scaling is completely general. A new approximation to the universal ac conduct...... conductivity arising in the extreme disorder limit of the symmetric hopping model, the "diffusion cluster approximation," is presented and compared to computer simulations and experiments.......Recent scaling results for the ac conductivity of ionic glasses by Roling et al. [Phys. Rev. Lett. 78, 2160 (1997)] and Sidebottom [Phys. Rev. Lett. 82, 3653 (1999)] are discussed. We prove that Sidebottom's version of scaling is completely general. A new approximation to the universal ac...

Final Report - ILAW PCT, VHT, Viscosity, and Electrical Conductivity Model Development, VSL-07R1230-1

Energy Technology Data Exchange (ETDEWEB)

Kruger, Albert A.; Cooley, S. K.; Joseph, I.; Pegg, I. L.; Piepel, G. F.; Gan, H.; Muller, I.

2013-12-17

This report describes the results of work and testing specified by the Test Specifications (24590-LAW-TSP-RT-01-013 Rev.1 and 24590-WTP-TSP-RT-02-001 Rev.0), Test Plans (VSL-02T4800-1 Rev.1 & TP-RPP-WTP-179 Rev.1), and Text Exception (24590-WTP-TEF-RT-03-040). The work and any associated testing followed established quality assurance requirements and conducted as authorized. The descriptions provided in this test report are an accurate account of both the conduct of the work and the data collected. Results required by the Test Plans are reported. Also reported are any unusual or anomalous occurrences that are different from the starting hypotheses. The test results and this report have been reviewed and verified.

Comment on “Beamstrahlung considerations in laser-plasma-accelerator-based linear colliders”

Directory of Open Access Journals (Sweden)

Valeri Lebedev

2013-10-01

Full Text Available Schroeder, Esarey, Geddes, Benedetti, and Leemans [Phys. Rev. ST Accel. Beams 13, 101301 (2010PRABFM1098-440210.1103/PhysRevSTAB.13.101301 and Phys. Rev. ST Accel. Beams 15, 051301 (2012PRABFM1098-440210.1103/PhysRevSTAB.15.051301] have proposed a set of parameters for a TeV-scale collider based on plasma wakefield accelerator principles. In particular, it is sugested that the luminosities greater than 10^{34}  cm^{-2} s^{-1} are attainable for an electron-positron collider. In this Comment we dispute this set of parameters on the basis of first principles. The interactions of accelerating beam with plasma impose fundamental limitations on beam properties and, thus, on attainable luminosity values.

Dicty_cDB: Contig-U16335-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 1 ( EY502726 ) CBBP6523.fwd CBBP Hirudo medicinalis hermaphrodit... 44 5.3 1 ( EY502725 ) CBBP6523.rev CBBP Hirudo medicina...lis hermaphrodit... 44 5.3 1 ( EY493532 ) CBBP19518.fwd CBBP Hirudo medicinalis hermaphrodi...... 44 5.3 1 ( EY493531 ) CBBP19518.rev CBBP Hirudo medicinalis hermaphrodi... 44 ...5.3 1 ( EY489048 ) CBBP16804.fwd CBBP Hirudo medicinalis hermaphrodi... 44 5.3 1 ( EY489047 ) CBBP16804.rev CBBP Hirudo medicina

Dicty_cDB: Contig-U05033-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 35269 Global-Ocean-Sampling_GS-34-01-01-1... 48 0.13 2 ( EY497680 ) CBBP3693.rev CBBP Hirudo medicinalis her...maphrodit... 50 0.13 1 ( EY493998 ) CBBP19771.rev CBBP Hirudo medicinalis hermaph...rodi... 50 0.13 1 ( EY487045 ) CBBP15563.fwd CBBP Hirudo medicinalis hermaphrodi... 50 0.13 1 ( EY487044 ) C...BBP15563.rev CBBP Hirudo medicinalis hermaphrodi... 50 0.13 1 ( AC116305 ) Dictyostelium discoideum chromoso

Indications for an inducible component of error-prone DNA repair in yeast.

OpenAIRE

Siede, W.; Eckardt, F.

1984-01-01

In a thermoconditional mutant of mutagenic DNA repair (rev 2ts = rad 5-8) of Saccharomyces cerevisiae recovery of survival and mutation frequencies can be monitored by incubating UV-irradiated cells in growth medium at a permissive temperature (23 degrees C) before plating and a shift to restrictive temperature (36 degrees C). Inhibition of protein synthesis with cycloheximide during incubation at permissive conditions blocks this REV 2 dependent recovery process in stationary phase rev 2ts c...

Quantum Tomography via Compressed Sensing: Error Bounds, Sample Complexity and Efficient Estimators (Open Access, Publisher’s Version)

Science.gov (United States)

2012-09-27

ultralong lifetimes and their tomographic state analysis Phys. Rev. Lett. 92 220402 [7] Resch K J, Walther P and Zeilinger A 2005 Full characterization...of a three-photon Greenberger– Horne– Zeilinger state using quantum state tomography Phys. Rev. Lett. 94 070402 [8] Häffner H et al 2005 Scalable...Iterative algorithm for reconstruction of entangled states Phys. Rev. A 63 040303 [74] Molina-Terriza G, Vaziri A, Řeháček J, Hradil Z and Zeilinger

EXPERIMENTAL INVESTIGATION OF THE EFFECT OF MACHINIG PARAMETERS OVER CUTTING FORCE AND SURFACE ROUGHNESS IN THE MACHINABILITY OF AA5052 ALLOY

Directory of Open Access Journals (Sweden)

Hasan GÖKKAYA

2006-03-01

Full Text Available In this study, the effects of different cutting and feed rates over average surface roughness and main cutting force during the machinability of AA5052 aluminum alloy with uncoated cemented carbide insert were evaluated. In the experiments, stable depth of cut (1.5 mm, four different cutting speeds (200, 300, 400, 500 m/min and five different feed rates (0.10, 0.15, 0.20, 0.25, 0.30 mm/rev were used. Based on cutting and feed rates, the lowest main cutting force was obtained as 113 in 500 m/min cutting speed and 0.10 mm/rev feed rate and the highest cutting force was obtained as 332 N in 200 m/min cutting speed and 0.30 mm/rev feed rate. The lowest average surface roughness was obtained as 0.95 µm in 200 m/min cutting speed and 0.10 mm/rev feed rate and the highest average surface roughness was obtained as 6.65 µm in 300 m/min cutting speed and 0.30 mm/rev feed rate.

Tool feed influence on the machinability of CO(2) laser optics.

Science.gov (United States)

Arnold, J B; Steger, P J; Saito, T T

1975-08-01

Influence of tool feed on reflectivity of diamond-machined surfaces was evaluated using materials (gold, silver, and copper) from which CO(2) laser optics are primarily produced. Fifteen specimens were machined by holding all machining parameters constant, except tool feed. Tool feed was allowed to vary by controlled amounts from one evaluation zone (or part) to another. Past experience has verified that the quality of a diamond-machined surface is not a function of the cutting velocity; therefore, this experiment was conducted on the basis that a variation in cutting velocity was not an influencing factor on the diamondturning process. Inspection results of the specimens indicated that tool feeds significantly higher than 5.1 micro/rev (200 microin./rev) produced detrimental effects on the machined surfaces. In some cases, at feeds as high as 13 microm/rev (500 microin./rev), visible scoring was evident. Those surfaces produced with tool feeds less than 5.1 microm/rev had little difference in reflectivity. Measurements indicat d that their reflectivity existed in a range from 96.7% to 99.3% at 10.6 microm.

Application of rare-earth magnets in high-performance electric machines

International Nuclear Information System (INIS)

Ramsden, V.S.

1998-01-01

Some state of the art developments of high-performance machines using rare-earth magnets are reviewed with particular examples drawn from a number of novel machine designs developed jointly by the Faculty of Engineering, University of Technology, Sydney (UTS) and CSIRO Telecommunications and Industrial Physics. These designs include an 1800 W, 1060 rev/min, 98% efficient solar car in-wheel motor using a Halbach magnet array, axial flux, and ironless winding; a 1200 W, 3000 rev/min, 91% efficient solar-powered, water-filled, submersible, bore-hole pump motor using a surface magnet rotor; a 500 W, 10000 rev/min, 87% efficient, oil-filled, oil-well tractor motor using a 2-pole cylindrical magnet rotor and slotless winding; a 75 kW, 48000 rev/min, 97% efficient, high-speed compressor drive with 2-pole cylindrical magnet rotor, slotted stator, and refrigerant cooling; and a 20 kW, 211 rev/min, 87% efficient, direct-drive generator for wind turbines with very low starting torque using an outer rotor with surface magnets and a slotted stator. (orig.)

The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis

KAUST Repository

Kim, Hyungsae

2010-10-05

Dof proteins are transcription factors that have a conserved single zinc finger DNA-binding domain. In this study, we isolated an activation tagging mutant Dof5.1-D exhibiting an upward-curling leaf phenotype due to enhanced expression of the REV gene that is required for establishing adaxialabaxial polarity. Dof5.1-D plants also had reduced transcript levels for IAA6 and IAA19 genes, indicating an altered auxin biosynthesis in Dof5.1-D. An electrophoretic mobility shift assay using the Dof5.1 DNA-binding motif and the REV promoter region indicated that the DNA-binding domain of Dof5.1 binds to a TAAAGT motif located in the 5′-distal promoter region of the REV promoter. Further, transient and chromatin immunoprecipitation assays verified binding activity of the Dof5.1 DNA-binding motif with the REV promoter. Consistent with binding assays, constitutive over-expression of the Dof5.1 DNA-binding domain in wild-type plants caused a downward-curling phenotype, whereas crossing Dof5.1-D to a rev mutant reverted the upward-curling phenotype of the Dof5.1-D mutant leaf to the wild-type. These results suggest that the Dof5.1 protein directly binds to the REV promoter and thereby regulates adaxialabaxial polarity. © 2010 Blackwell Publishing Ltd.

The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis

KAUST Repository

Kim, Hyungsae; Kim, Sungjin; Abbasi, Nazia; Bressan, Ray Anthony; Yun, Daejin; Yoo, Sangdong; Kwon, SukYun; Choi, Sangbong

2010-01-01

Dof proteins are transcription factors that have a conserved single zinc finger DNA-binding domain. In this study, we isolated an activation tagging mutant Dof5.1-D exhibiting an upward-curling leaf phenotype due to enhanced expression of the REV gene that is required for establishing adaxialabaxial polarity. Dof5.1-D plants also had reduced transcript levels for IAA6 and IAA19 genes, indicating an altered auxin biosynthesis in Dof5.1-D. An electrophoretic mobility shift assay using the Dof5.1 DNA-binding motif and the REV promoter region indicated that the DNA-binding domain of Dof5.1 binds to a TAAAGT motif located in the 5′-distal promoter region of the REV promoter. Further, transient and chromatin immunoprecipitation assays verified binding activity of the Dof5.1 DNA-binding motif with the REV promoter. Consistent with binding assays, constitutive over-expression of the Dof5.1 DNA-binding domain in wild-type plants caused a downward-curling phenotype, whereas crossing Dof5.1-D to a rev mutant reverted the upward-curling phenotype of the Dof5.1-D mutant leaf to the wild-type. These results suggest that the Dof5.1 protein directly binds to the REV promoter and thereby regulates adaxialabaxial polarity. © 2010 Blackwell Publishing Ltd.

The Annual Meeting (16th) and the 20th Day of Scientific Lectures of the National Society of Black Physicists

Science.gov (United States)

1993-04-24

Johnson, J. Kiraly, E. Moshey, G. Renda , S. Sesnic, N. R. Sauthoff, F. Tenney and K. M. Young, Rev. Sci. Instrum. 56, 840 (1985). (4) J. Schivell, G... Renda , J. Lawrence, and H. Hsuan, Rev. Sci. Instrum. 53, 1527 (1982); J. Schivell, Rev. Sci. Instrum. 56, 972 (1985) (5) L. A. Vainshtemi and U. I...was confused in at least two major ways. First, the descriptions of both were in our lab books allowing us extra timE to prepare for the second

Analysis of Protein-RNA and Protein-Peptide Interactions in Equine Infectious Anemia

Energy Technology Data Exchange (ETDEWEB)

Lee, Jae-Hyung [Iowa State Univ., Ames, IA (United States)

2007-01-01

Macromolecular interactions are essential for virtually all cellular functions including signal transduction processes, metabolic processes, regulation of gene expression and immune responses. This dissertation focuses on the characterization of two important macromolecular interactions involved in the relationship between Equine Infectious Anemia Virus (EIAV) and its host cell in horse: (1) the interaction between the EIAV Rev protein and its binding site, the Rev-responsive element (RRE) and (2) interactions between equine MHC class I molecules and epitope peptides derived from EIAV proteins. EIAV, one of the most divergent members of the lentivirus family, has a single-stranded RNA genome and carries several regulatory and structural proteins within its viral particle. Rev is an essential EIAV regulatory encoded protein that interacts with the viral RRE, a specific binding site in the viral mRNA. Using a combination of experimental and computational methods, the interactions between EIAV Rev and RRE were characterized in detail. EIAV Rev was shown to have a bipartite RNA binding domain contain two arginine rich motifs (ARMs). The RRE secondary structure was determined and specific structural motifs that act as cis-regulatory elements for EIAV Rev-RRE interaction were identified. Interestingly, a structural motif located in the high affinity Rev binding site is well conserved in several diverse lentiviral genoes, including HIV-1. Macromolecular interactions involved in the immune response of the horse to EIAV infection were investigated by analyzing complexes between MHC class I proteins and epitope peptides derived from EIAV Rev, Env and Gag proteins. Computational modeling results provided a mechanistic explanation for the experimental finding that a single amino acid change in the peptide binding domain of the quine MHC class I molecule differentially affectes the recognitino of specific epitopes by EIAV-specific CTL. Together, the findings in this

Cycling cadence affects heart rate variability

International Nuclear Information System (INIS)

Lunt, Heather C; Corbett, Jo; Barwood, Martin J; Tipton, Michael J

2011-01-01

The purpose of this study was to examine the effect different cycling cadences have on heart rate variability (HRV) when exercising at constant power outputs. Sixteen males had ECG and respiratory measurements recorded at rest and during 8, 10 min periods of cycling at four different cadences (40, 60, 80 and 100 revs min −1 ) and two power outputs (0 W (unloaded) and 100 W (loaded)). The cycling periods were performed following a Latin square design. Spectral analyses of R–R intervals by fast Fourier transforms were used to quantify absolute frequency domain HRV indices (ms 2 ) during the final 5 min of each bout, which were then log transformed using the natural logarithm (Ln). HRV indices of high frequency (HF) power were reduced when cadence was increased (during unloaded cycling (0 W) log transformed HF power decreased from a mean [SD] of 6.3 [1.4] Ln ms 2 at 40 revs min −1 to 3.9 [1.3] Ln ms 2 at 100 revs min −1 ). During loaded cycling (at 100 W), the low to high frequency (LF:HF) ratio formed a 'J' shaped curve as cadence increased from 40 revs min −1 (1.4 [0.4]) to 100 revs min −1 (1.9 [0.7]), but dipped below the 40 revs min −1 values during the 60 revs min −1 1.1 (0.3) and 80 revs min −1 1.2 (0.6) cadence conditions. Cardiac frequency (f C ) and ventilatory variables were strongly correlated with frequency domain HRV indices (r = −0.80 to −0.95). It is concluded that HRV indices are influenced by both cycling cadence and power output; this is mediated by the f C and ventilatory changes that occur as cadence or exercise intensity is increased. Consequently, if HRV is assessed during exercise, both power output/exercise intensity and cadence should be standardized

Families of quantum fingerprinting protocols

Science.gov (United States)

Lovitz, Benjamin; Lütkenhaus, Norbert

2018-03-01

We introduce several families of quantum fingerprinting protocols to evaluate the equality function on two n -bit strings in the simultaneous message passing model. The original quantum fingerprinting protocol uses a tensor product of a small number of O (logn ) -qubit high-dimensional signals [H. Buhrman et al., Phys. Rev. Lett. 87, 167902 (2001), 10.1103/PhysRevLett.87.167902], whereas a recently proposed optical protocol uses a tensor product of O (n ) single-qubit signals, while maintaining the O (logn ) information leakage of the original protocol [J. M. Arazola and N. Lütkenhaus, Phys. Rev. A 89, 062305 (2014), 10.1103/PhysRevA.89.062305]. We find a family of protocols which interpolate between the original and optical protocols while maintaining the O (logn ) information leakage, thus demonstrating a tradeoff between the number of signals sent and the dimension of each signal. There has been interest in experimental realization of the recently proposed optical protocol using coherent states [F. Xu et al., Nat. Commun. 6, 8735 (2015), 10.1038/ncomms9735; J.-Y. Guan et al., Phys. Rev. Lett. 116, 240502 (2016), 10.1103/PhysRevLett.116.240502], but as the required number of laser pulses grows linearly with the input size n , eventual challenges for the long-time stability of experimental setups arise. We find a coherent state protocol which reduces the number of signals by a factor 1/2 while also reducing the information leakage. Our reduction makes use of a simple modulation scheme in optical phase space, and we find that more complex modulation schemes are not advantageous. Using a similar technique, we improve a recently proposed coherent state protocol for evaluating the Euclidean distance between two real unit vectors [N. Kumar et al., Phys. Rev. A 95, 032337 (2017), 10.1103/PhysRevA.95.032337] by reducing the number of signals by a factor 1/2 and also reducing the information leakage.

Analysis Bounding Double Shell Tank (DST) Performance for the Hanford Tank Waste Operation Simulator Case 2

International Nuclear Information System (INIS)

SMITH, D.F.

2002-01-01

The purpose of this analysis is to compare the latest Tank Farm Contractor Operation and Utilization Plan (HNF-SD-WM-SP-012, Rev. 3) ''Case 2'' operating scenarios with a previous bounding analysis for the Double-Shell Tank (DST) System in order to provide a technical assessment against the current set of DST System performance requirements. A later update to HNF-SD-WM-SP-012 (i.e., Rev. 3A), released in late December 2001, did not impact the results of this analysis. This analysis provides technical support for revising the Performance Requirements for the Double-Shell Tank System, HNF-2168, Rev. 3, used as the basis for defining performance requirements noted in System Specification for the Double-Shell Tank System, HNF-SD-WM-TRD-007. Rev. 1

Analysis of mutagenic DNA repair in a thermoconditional mutant of Saccharomyces cerevisiae. Pt. 3

International Nuclear Information System (INIS)

Siede, W.; Eckardt, F.

1986-01-01

Recent studies regarding the influence of cycloheximide on the temperature-dependent increase in survival and mutation frequencies of a thermoconditional rev2 mutant lead to the suggestion that the REV2-coded mutagenic repair function is UV-inducible. In the present study we show that stationary-phase rev2sup(ts) cells are characterized by a biphasic linear-quadratic dose-dependence of mutation induction ('mutation kinetics') of ochre alleles at 23 0 C (permissive temperature) but linear kinetics at the restrictive temperature of 36 0 C. Mathematical analysis using a model based on Poisson statistics and a further mathematical procedure, the calculation of 'apparent survival', support the assumption kinetics investigated can be attributed to a UV-inducible component of mutagenic DNA repair controlled by the REV2 gene. (orig.)

Inclusive breakup calculations in angular momentum basis: Application to 7Li+58Ni

Science.gov (United States)

Lei, Jin

2018-03-01

The angular momentum basis method is introduced to solve the inclusive breakup problem within the model proposed by Ichimura, Austern, and Vincent [Phys. Rev. C 32, 431 (1985), 10.1103/PhysRevC.32.431]. This method is based on the geometric transformation between different Jacobi coordinates, in which the particle spins can be included in a natural and efficient way. To test the validity of this partial wave expansion method, a benchmark calculation is done comparing with the one given by Lei and Moro [Phys. Rev. C 92, 044616 (2015), 10.1103/PhysRevC.92.044616]. In addition, using the distorted-wave Born approximation version of the IAV model, applications to 7Li+58Ni reactions at energies around Coulomb barrier are presented and compared with available data.

High energy neutrinos from astrophysical accelerators of cosmic ray nuclei

Science.gov (United States)

Anchordoqui, Luis A.; Hooper, Dan; Sarkar, Subir; Taylor, Andrew M.

2008-02-01

Ongoing experimental efforts to detect cosmic sources of high energy neutrinos are guided by the expectation that astrophysical accelerators of cosmic ray protons would also generate neutrinos through interactions with ambient matter and/or photons. However, there will be a reduction in the predicted neutrino flux if cosmic ray sources accelerate not only protons but also significant numbers of heavier nuclei, as is indicated by recent air shower data. We consider plausible extragalactic sources such as active galactic nuclei, gamma ray bursts and starburst galaxies and demand consistency with the observed cosmic ray composition and energy spectrum at Earth after allowing for propagation through intergalactic radiation fields. This allows us to calculate the expected neutrino fluxes from the sources, normalized to the observed cosmic ray spectrum. We find that the likely signals are still within reach of next generation neutrino telescopes such as IceCube.PACS95.85.Ry98.70.Rz98.54.Cm98.54.EpReferencesFor a review, see:F.HalzenD.HooperRep. Prog. Phys.6520021025A.AchterbergIceCube CollaborationPhys. Rev. Lett.972006221101A.AchterbergIceCube CollaborationAstropart. Phys.262006282arXiv:astro-ph/0611063arXiv:astro-ph/0702265V.NiessANTARES CollaborationAIP Conf. Proc.8672006217I.KravchenkoPhys. Rev. D732006082002S.W.BarwickANITA CollaborationPhys. Rev. Lett.962006171101V.Van ElewyckPierre Auger CollaborationAIP Conf. Proc.8092006187For a survey of possible sources and event rates in km3 detectors see e.g.,W.BednarekG.F.BurgioT.MontaruliNew Astron. Rev.4920051M.D.KistlerJ.F.BeacomPhys. Rev. D742006063007A. Kappes, J. Hinton, C. Stegmann, F.A. Aharonian, arXiv:astro-ph/0607286.A.LevinsonE.WaxmanPhys. Rev. Lett.872001171101C.DistefanoD.GuettaE.WaxmanA.LevinsonAstrophys. J.5752002378F.A.AharonianL.A.AnchordoquiD.KhangulyanT.MontaruliJ. Phys. Conf. Ser.392006408J.Alvarez-MunizF.HalzenAstrophys. J.5762002L33F.VissaniAstropart. Phys.262006310F

Phonon Squeezing by Raman Scattering.

Science.gov (United States)

Nori, Franco; Hu, Xuedong

1997-03-01

We have studied quantum fluctuation properties of a crystal lattice, and proposed several mechanisms to achieve this goal(X. Hu and F. Nori, Phys. Rev. Lett. 76, 2294 (1996); Phys. Rev. B 53, 2419 (1996); preprint.).

Magnetotransport in Two Dimensional Electron Systems Under Microwave Excitation and in Highly Oriented Pyrolytic Graphite

Science.gov (United States)

2012-01-01

Phys. Rev. Lett. 82, 2147 (1999). [89] Y. Zhang, Y. Tan, H. L. Stormer and P. Kim, Nature 438, 10 (2005). [90] J. W. McClure, Phys. Rev. 108, 612 (1957...Phys. 2, 595 (2006). [97] H. L. Stormer , J. P. Eisenstein, A. C. Gossard, W. Wiegmann, and K. Baldwin, Phys. Rev. Lett. 56, 85 (1985). [98] B. A...Sadowski, J. M. Schneider, and M. Potemski, J. Phys.: Cond. Matter 20, 454223 (2008). [108] W. Pan, J. S. Xia, H. L. Stormer , D. C. Tsui, C. L

Radiology. Basic course 2. 4. rev. ed.

International Nuclear Information System (INIS)

Heilmann, A.; Steinhorst, M.

1990-06-01

The first part presents the subject catalogue in general radiology and a comprehensive refresher course. The main facts most frequently asked in examinations are dealt with in detail. The second part lists all important original questions from the field of general radiology, arranged by the chapters of the subject catalogue. For quick checking, correct answers are shown at the bottom of each page. The commentary presents a summary of examination problems, related subjects and problems, and hints referring to differential diagnostic aspects. The commentary part is followed by a reproduction of the original examination problems presented from March 1988 through August 1989, each collection of problems with a commentary. Students may test their state of knowledge by going through these collections of problems. There also is a collection of original images belonging to the questions. (orig./HP) With 40 figs [de

CVD calibration light systems specifications. Rev. 0

International Nuclear Information System (INIS)

Mcllwain, A. K.

1992-04-01

Two prototype Cerenkov Viewing Device Calibration Light systems for the Mark IV CVD have been fabricated. They consist of a maintenance unit that will be used by the IAEA maintenance staff and a field unit that will be used by IAEA inspectors. More detailed information on the design of the calibration units can be obtained from the document SSP-39 and additional information on the Mark IV CVD can be obtained from the operating manual published as Canadian Safeguards Support Program document CSSP 6. The specifications refer to the prototype units which will be demonstrated to the IAEA in 1992 May. Based upon the feedback from the IAEA, the instruments will be changed in the final production models to provide devices that more closely satisfy the needs of the end users

ASC FY17 Implementation Plan, Rev. 1

Energy Technology Data Exchange (ETDEWEB)

Hamilton, P. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-06-14

The Stockpile Stewardship Program (SSP) is an integrated technical program for maintaining the safety, surety, and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational capabilities to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources that support annual stockpile assessment and certification, study advanced nuclear weapons design and manufacturing processes, analyze accident scenarios and weapons aging, and provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balance of resources, including technical staff, hardware, simulation software, and computer science solutions.

Energy from agricultural animal wastes. Rev. ed.

International Nuclear Information System (INIS)

1994-12-01

This technology status report discusses the production of animal wastes in the UK, and the environmental problems caused by direct use of the waste as fertilisers or disposal by landfilling. The effects of the moisture content of the waste on the choice of technology is examined, and the use of anaerobic digestion for wetter wastes to produce biogas and combustion of dryer wastes to produce heat, power and phosphate- and potash-rich ash are discussed. Market opportunities, and the economics and environmental impacts of both technologies are investigated

Facts on nuclear power. 4. rev. ed.

International Nuclear Information System (INIS)

1987-06-01

The information booklet summarizes physical principles and other fundamental background information relating to nuclear power. The material is subdivided into various brief chapters with tables and illustrations discussing aspects such as: Basic terms and data, energy demand and supply, economics, nuclear power plants in operation, radiation protection, reactor safety, and nuclear waste management. A brief outline of the history of nuclear power in the FRG is given, and a list of addresses and literature for further reading. (UA) [de

Performance appraisal and advancement exercise 2006 (Rev)

CERN Multimedia

Human Resources Department

2005-01-01

The 2006 performance appraisal and advancement exercise will start in the usual way with annual interviews between staff and their supervisors. This year, these interviews should be held in the period from 1 December 2005 to 15 March 2006*. In this connection, a number of improvements to the procedures relating to the interviews and performance appraisals are currently under study. Administrative Circular No. 26 (Procedures Governing the Career Development of Staff Members) and the electronic MAPS form in EDH are being reviewed and will be available from December onwards. In the meantime supervisors can start the interview procedure. HR Department will shortly provide further information on this subject. The 2005 MAPS report can be retrieved for consultation at any time via EDH. * Instead of 31 March, as indicated in the electronic Bulletin No. 47 of 21 November 2005 Human Resources Department Tel. 73566

Traumatological radiodiagnostics. 2. rev. and enlarged ed.

International Nuclear Information System (INIS)

Birzle, H.; Bergleiter, R.; Kuner, E.H.

1985-01-01

Traumatology accounts for a major part of diagnostic radiography. Correct application and assessment of imaging methods when examining freshly injured patients is of paramount importance and requires a good deal of experience. To this end, the book displays more than 1000 individual pictures. A brief text introduces to the peculiarities of the body region concerned. Typical injury mechanisms and available diagnostic methods are demonstrated including their advantages and disadvantages. This is followed by a comprehensive collection of pictures which also contains CT's and sonographs. With 530 figs [de

Pipeline engineering. 8. rev. and enl. ed.

International Nuclear Information System (INIS)

Wagner, W.

2000-01-01

Apart from calculating the strength of pipeline components planning and design are the most important tasks on the areas of apparatus manufacturing, fluid engineering, process engineering and thermal engineering. It is therefore necessary that the flow diagrams of a plant are clearly understandable and in accordance with the technical rules even in the early stages of planning. This book concentrates on steel pipeline which are not laid underground but of the type used mostly in industrial applications. The pictures and equations provided can be used for the design of pipelines, tables and diagrams are given to facilitate estimation of elasticity, pipeline pressure losses and insulating thicknesses. An overview of the equations is given at the end of the book. Many examples facilitate learning. (orig.) [de

Environmental economics. 4. rev. and enl. ed.

International Nuclear Information System (INIS)

Wicke, L.

1993-01-01

This textbook is intended to reveal and explain the most important issues in environmental economics, a) on the basis of a systematic breakdown of the whole field of environmental economics, and b) with the aid of numerous examples taken from practical environmental policy. The material presented in this book has been grouped according to various subjects as, e.g., instruments of environmental policy, effects of pollution control measures on the economy, etc. The conclusions drawn by the author as a result of his study can be summarized in the following general statement: Democratic states with a free economic system corresponding to the social market economy of the FRG for instance are well endowed with the prerequisites for successfully tackling environmental problems, both in terms of financial and regulatory policy- and experience has already shown that the approach adopted is a practicable and promising one. However, there could be much more success along this line of the political instruments were given greater impetas and impact, and if the regulatory instruments were designed so as to gain more effectiveness. (orig.) [de

Thermodynamics and statistical physics. 2. rev. ed.

International Nuclear Information System (INIS)

Schnakenberg, J.

2002-01-01

This textbook covers tthe following topics: Thermodynamic systems and equilibrium, irreversible thermodynamics, thermodynamic potentials, stability, thermodynamic processes, ideal systems, real gases and phase transformations, magnetic systems and Landau model, low temperature thermodynamics, canonical ensembles, statistical theory, quantum statistics, fermions and bosons, kinetic theory, Bose-Einstein condensation, photon gas

Radiology of the pancreas. 2. rev. ed.

International Nuclear Information System (INIS)

Baert, A.L.; Van Hoe, L.; Delorme, G.

1999-01-01

Radiology of the Pancreas discusses the diagnostic role of the various imaging modalities currently available for the assessment of pancreatic anatomy and disease. In comparison with the first edition, new technical developments (helical CT, ultrafast magnetic resonance imaging, color Doppler ultrasound, laparoscopic ultrasound), have been included, and several chapters have been significantly expanded. With the aid of numerous illustrations, the normal radiological anatomy, anatomical variants, the typical and atypical radiological features of both common and uncommon diseases, and potential pitfalls are considered in depth. All of the chapters have been written by recognized experts in the field, and the book should be of value to all radiologists and other specialists who treat patients with pancreatic disease or who have an interest in the subject. (orig.)

Transesophageal echocardiography. 3. rev. and enl. ed.

International Nuclear Information System (INIS)

Lambertz, Heinz; Lethen, Harald

2013-01-01

The book on transesophageal echocardiography covers the following issues: Development of transesophageal echocardiography, technical advances; indications and contraindication for transesophageal echocardiography; systematic of the medical examination process; cardiac valves and valve prostheses; mitral and aortic valvuloplasty, TAVI and interventional treatment of mitral regurgitation; infectious endocarditis; one-way and effluence disturbances of the left and right ventricle; diseases of the thoracic aorta; undefined right ventricle enlargement; lung embolism, acute infarct complications; TEE during anesthesia and perioperative intensive medicine, cardiac sources of embolism; cardiac tumors, mediastinal lymph nodes; pericardiac diseases; congenital heart diseases in childhood and adulthood; catheter interventions and heart valve reconstruction; surgically corrected congenital cardiac defects; intracavitary versus transesophageal echocardiography; three-dimensional TEE; coronary diagnostics; ischemia and vitality diagnostics.

16oct AM poster prog rev.pmd

Indian Academy of Sciences (India)

Administrator

1530 T V Ramakrishnan. T V Ramakrishnan. T V Ramakrishnan, BHU, Varanasi. Walter Kohn and the rise of condensed matter physics. 1600 Swapan K Ghosh. Swapan K Ghosh. Swapan K Ghosh, BARC, Mumbai. Density functional theory for materials modeling at different length scales: A legacy of Walter Kohn.

The First Reactor, 40th Anniversary (rev.)

Energy Technology Data Exchange (ETDEWEB)

Allardice, Corbin; Trapnell, Edward R; Fermi, Enrico; Fermi, Laura; Williams, Robert C

1982-12-01

This booklet, an updated version of the original booklet describing the first nuclear reactor, was written in honor of the 40th anniversary of the first reactor or "pile". It is based on firsthand accounts told to Corbin Allardice and Edward R. Trapnell, and includes recollections of Enrico and Laura Fermi.

Physics, radiology and chemistry. 6. rev. ed.

International Nuclear Information System (INIS)

Linde, O.K.; Knigge, H.J.

1981-01-01

The scientific basic disciplines of physics and chemistry are the beginning of all medical teaching. They are suitable to clarify medical and biochemical problems in their causality by means of their own thinking methodics as well as by the information provided. This book attempts to point out the relationships of physics, radiology and chemistry to neighbouring disciplines, especially to practical medicine. Greater importance must naturally be given here to the examples of individual fundamental facts than to the conveying of pure theory from books. The statements and questions on self control ordered according to chapter represent a minimum learning for the students which can be extended as required. (orig./ORU) [de

Detectors for particle radiation. 2. rev. ed.

International Nuclear Information System (INIS)

Kleinknecht, K.

1987-01-01

This book is a description of the set-up and mode of action of detectors for charged particles and gamma radiation for students of physics, as well as for experimental physicists and engineers in research and industry: Ionization chamber, proportional counter, semiconductor counter; proportional chamber, drift chamber, bubble chamber, spark chamber, photomultiplier, laser ionization, silicion strip detector; Cherenkov counter, transition radiation detector; electron-photon-cascade counter, hadron calorimeter; magnetic spectrometer; applications in nuclear medicine, geophysics, space travel, atom physics, nuclear physics, and high-energy physics. With 149 figs., 20 tabs [de

Imaging pelvic floor disorders. 2. rev. ed.

International Nuclear Information System (INIS)

Stoker, Jaap; Taylor, Stuart A.; DeLancey, John O.L.

2008-01-01

This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

2014 SRNL LDRD Annual Report, Rev. 0

Energy Technology Data Exchange (ETDEWEB)

Mcwhorter, S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2015-03-15

Laboratory Directed Research and Development is a congressionally authorized program that provides the ‘innovation inspiration’ from which many of the Laboratory’s multi-discipline advancements are made in both science and engineering technology. The program is the backbone for insuring that scientific, technical and engineering capabilities can meet current and future needs. It is an important tool in reducing the probability of technological surprise by allowing laboratory technical staff room to innovate and keep abreast of scientific breakthroughs. Drawing from the synergism among the EM and NNSA missions, and work from other federal agencies ensures that LDRD is the key element in maintaining the vitality of SRNL’s technical programs. The LDRD program aims to position the Laboratory for new business in clean energy, national security, nuclear materials management and environmental stewardship by leveraging the unique capabilities of the Laboratory to yield foundational scientific research in core business areas, while aligning with SRS strategic initiatives and maintaining a vision for ultimate DOE applications.

Harmful effects on plants. 2. rev. ed.

International Nuclear Information System (INIS)

Hock, B.; Elstner, E.F.

1988-01-01

The book deals with accidentally or purposefully induced harmful effects on plants, i.e. eukariyotes and fungi, with emphasis being placed on chemicals as the main pollutants. After discussing the quantification of damage as a prerequisite for detecting, defining, and possibly preventing, damage to plants by toxic substances in the environment, the second part of the book deals with the harmful effects that are purposefully induced, for example in agriculture or horticulture, by employment of pesticides (herbicides or fungicides). In this context, all aspects of uptake, metabolism, and detoxication are discussed, especially referring to the molecular conditions of relevance to a selective elimination of metabolic or developmental processes in the plants, which is explained by the effects of pesticides and antibiotics. Injuries caused by autogenous substances in the plants, upon exceeding a certain amount or dose are also explained, together with effects of physical factors (as e.g. ionizing radiation), or biogenic factors (as e.g. parasites). (ECB) [de

Horns Rev II, 2-D Model Tests

DEFF Research Database (Denmark)

Andersen, Thomas Lykke; Frigaard, Peter

This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), on behalf of Energy E2 A/S part of DONG Energy A/S, Denmark. The objective of the tests was: to investigate the combined influence of the pile...... diameter to water depth ratio and the wave hight to water depth ratio on wave run-up of piles. The measurements should be used to design access platforms on piles....

Horns Rev II, 2D-Model Tests

DEFF Research Database (Denmark)

Andersen, Thomas Lykke; Brorsen, Michael

This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), Denmark. The starting point for the present report is the previously carried out run-up tests described in Lykke Andersen & Frigaard, 2006. The......-shaped access platforms on piles. The Model tests include mainly regular waves and a few irregular wave tests. These tests have been conducted at Aalborg University from 9. November, 2006 to 17. November, 2006.......This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), Denmark. The starting point for the present report is the previously carried out run-up tests described in Lykke Andersen & Frigaard, 2006....... The objective of the tests was to investigate the impact pressures generated on a horizontal platform and a cone platform for selected sea states calibrated by Lykke Andersen & Frigaard, 2006. The measurements should be used for assessment of slamming coefficients for the design of horizontal and cone...

Horns Rev II, 2D-Model Tests

DEFF Research Database (Denmark)

Andersen, Thomas Lykke; Frigaard, Peter

This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU). The objective of the tests was: To investigate the combined influence of the pile diameter to water depth ratio and the wave height to water...... depth ratio on wave run-up of piles. The measurements should be used to design access platforms on piles. The Model tests include: Calibration of regular and irregular sea states at the location of the pile (without structure in place). Measurement of wave run-up for the calibrated sea states...... on the front side of the pile (0 to 90 degrees). These tests have been conducted at Aalborg University from 9. October, 2006 to 8. November, 2006. Unless otherwise mentioned, all values given in this report are in model scale....

Fundamentals of environmental engineering. 2. rev. ed.

International Nuclear Information System (INIS)

Bank, M.

1994-01-01

'Fundamentals of Environmental Engineering' contains the technical and legal bases for the force environmental areas water supply and waste water disposal, clean air, waste avoidance and waste disposal, as well as noise protection in compact form. Particular scope was allowed for the description of the linkages between the individual environmental areas - for instance, waste combustion and clean air, waste deposition at landfills and treatment of leachate, residual products from successful water and air pollution control measures. For all those who have to familiarize themselves with the complex subject of 'environmental engineering' while in training or during continuing education this book offers a broad approach to the essential general, technical and legal bases. (orig.) [de

Physics, radiology, and chemistry. 7. rev. ed.

International Nuclear Information System (INIS)

Linde, O.K.; Knigge, H.J.

1986-01-01

This book is an introduction to physics and chemistry especially for medical personnel. After a general introduction, measurement methods, mechanics including mechanics of solid bodies, fluids and gases, heat, optics, acoustics, electricity, radiations including their biological effects, general chemistry, inorganic and organic chemistry are treated. Every chapter contains exercises mostly in connection with medical and biological effects. Furthermore, connections with biology and medicine are considered. The chapters on physiological chemistry, computer and information theory, chemistry and ecology, and metabolism have been rewritten. (orig./HP) [de

Teaching atlas of mammography. 2. rev. ed.

International Nuclear Information System (INIS)

Tabar, L.; Dean, P.B.

1985-01-01

The purpose of this Atlas is to teach radiologists how to analyze mammograms and arrive at the correct diagnosis through proper evaluation of the findings. The illustrated cases cover practically the entire spectrum of breast abnormalities. They are based upon referred patient material as well as 80000 mammographic screening examinations. There are two basic steps in the interpretation of mammograms: perception and analysis. Since the greatest benefit of mammography lies in the detection of breast carcinoma in its earliest possible stages, every mammogram must be systematically surveyed for the subtle hints of malignancy. Perception is taught in this Atlas by describing a method for systematic viewing. The reader is then provided with a series of mammograms with obscure lesions to encourage practice with this method. With the help of a coordinate system, the lesions can be precisely located. Practice in perception continues throughout the Atlas. After detecting an abnormality on the mammogram, the diagnosis can be reached through a careful analysis of the X-ray signs. Additional projections, coned-down compression and magnetification views provide further help in this analytic workup. Rather than starting with the diagnosis and demonstrating typical findings, the approach of this Atlas is to teach the reader how to analyze the image and reach the correct diagnosis through proper evaluation of the X-ray signs. Prerequisites for the perception and evaluation of the X-ray signs are optimum technique, knowledge of anatomy and understanding of the pathological processes leading to the mammographic appearances. (orig.)

Boundless energy. 2. rev. ed.; Grenzenlose Energie

Energy Technology Data Exchange (ETDEWEB)

Haege, Walter

2007-07-01

For thousands of years, all cultures of man have described and researched life energy, whether they called it Qi, Chi, Prana, Od or Orgon. Since Rupert Sheldrake published his theory of morphogenetic fields, the subject has been accessible to the population in general and is contributing to the decline of the current paradigm of science. Knowledge that seamed indisputable since the time of Newton and Descartes is waning, and science must restructure itself on quite a different basis. Einstein, too, is becoming history. The book spans the discoveries of Lord Kelvin to Nikola Tesla to Prof. Dr.-Ing. K. Meyl whose potential eddy theory leads to a new understanding of the world. The key to this is the neutrino, and the fundamentals of neutrino physics are quite simple: At every moment, more than 60 thousand millions of neutrinos flow through us, controlling everything that exists. In his book, author Walter Haege shows how we can all utilise this indispensable neutrino power. It is a book for everyday practice, an indispensable reference manual for all those who intend a radical change in their view of the world and their way of living. (orig.) [German] Seit Jahrtausenden wird in allen Kulturen jene Energie beschrieben und erforscht, die uns steuert und unsere Zeit am Leben erhaelt, jene Energie mit den vielen Namen, von denen uns die bekanntesten, Qi, Chi, Prana, Od oder Orgon vielleicht gelaeufig sind. Seit Rupert Sheldrake und seiner wieder aufgegriffenen Theorie vom morphogenetischen Feld ist dieses Thema grossen Bevoelkerungskreisen neu zugaenglich geworden und traegt dazu bei, dass das jetzige Paradigma der Wissenschaften seinem Ende zugeht. Unser gesichertes Wissen, seit Newton und Descartes scheinbar unumstoesslich, geht dahin und die Wissenschaft muss sich auf gaenzlich anderer Grundlage neu formieren. Auch Einstein wird Geschichte. Die Wirbelphysik Lord Kelvins fuehrt uns ueber die sensationellen Entdeckungen Nikola Teslas zu dem Physiker Prof. Dr.-Ing. K. Meyl, der uns mit seiner Theorie der Potenzialwirbel zu einem neuen Weltverstaendnis fuehrt. Der Schluessel dazu heisst Neutrinos, wobei die Grundlage der Neutrinophysik gaenzlich einfach zu verstehen ist: Mehr als 60 Milliarden Neutrinos pro Sekunde und Quadratzentimeter - aus dem Weltraum kommend - durchfliessen uns und steuern alles was ist. Walter Haege zeigt in diesem Buch praktisch auf, wie jeder von uns diese so notwendige Neutrino-Energie selbst nutzen kann. Es Ist deshalb ein Praxisbuch, dessen Inhalt unverzichtbar fuer jenen Menschen ist, der seine Sicht der Welt und damit sein gesamtes Leben radikal auf neue Fuesse stellen will. (orig.)

Transport of radioactive materials. 2. rev. ed.

International Nuclear Information System (INIS)

Vogt, H.W.; Falkhof, W.; Heibach, K.; Ungermann, N.; Hungenberg, H.

1991-01-01

With the last changes in the Ordinance Concerning the Transport of Hazardous Goods two regulations which are important for the carrying trade were introduced: 1. The conveyer must train the driver. He must only employ reliable drivers. 2. The driver must participate in a training course (as of July 1, 1991). These obligations, which already existed in the past in regard to the transport of nuclear fuel, have been extended to include the transport of other radioactive materials. In part I the book deals with basic training courses for parcelled goods, and part II goes into the special knowledge which is required of drivers of radioactive materials. The parts consist of the following sections: 1. General regulations, 2, Responsibility when transporting hazardous goods, 3. General danger features, 4. Information on dangers and their designation, 5. The vehicle's equipment and carrying out the transport, 6. Measures for avoiding accidents. At the end of each section the participant in the course finds a series of questions which pertain to the subject matter just treated so that he can test his own learning performance. So as to make things easier for the trainee, the corect answers are listed in the appendix. As a supplementary section on radioactive materials, part II offers additional detailed explanations by experts in the field on the features of radioactive materials and the dangers they pose. In the margin - next to the instructory text - the key words are given so that the right place in the text of the instruction manual can be readily found. These key words are compiled in the appendix to form an index. (orig./HP) [de

Ensemble-based Probabilistic Forecasting at Horns Rev

DEFF Research Database (Denmark)

Pinson, Pierre; Madsen, Henrik

2009-01-01

forecasting methodology. In a first stage, ensemble forecasts of meteorological variables are converted to power through a suitable power curve model. This modelemploys local polynomial regression, and is adoptively estimated with an orthogonal fitting method. The obtained ensemble forecasts of wind power...

Reference Model 2: "Rev 0" Rotor Design

Energy Technology Data Exchange (ETDEWEB)

Barone, Matthew F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Berg, Jonathan Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Griffith, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2011-12-01

The preliminary design for a three-bladed cross-flow rotor for a reference marine hydrokinetic turbine is presented. A rotor performance design code is described, along with modifications to the code to allow prediction of blade support strut drag as well as interference between two counter-rotating rotors. The rotor is designed to operate in a reference site corresponding to a riverine environment. Basic rotor performance and rigid-body loads calculations are performed to size the rotor elements and select the operating speed range. The preliminary design is verified with a simple finite element model that provides estimates of bending stresses during operation. A concept for joining the blades and support struts is developed and analyzed with a separate finite element analysis. Rotor mass, production costs, and annual energy capture are estimated in order to allow calculations of system cost-of-energy. Evaluation Only. Created with Aspose.Pdf.Kit. Copyright 2002-2011 Aspose Pty Ltd Evaluation Only. Created with Aspose.Pdf.Kit. Copyright 2002-2011 Aspose Pty Ltd

Lungs, pleura, thoracal wall. 7. rev. ed.

International Nuclear Information System (INIS)

Stender, H.S.

1988-01-01

The book describes the anatomy of the lungs, as well as X-ray, computerized tomography, nuclear magnetic resonance, and nuclear-medical imaging techniques. Following a discussion of the general symptomatology of pulmonary diseases verifiable by X-ray, the individual diseases including inhalation damage from inorganic dusts and gases are dealt with. Traumatic thoracal conditions, the image of the thorax after operations, alterations of the thoracal wall, as well as pleural diseases are also discussed. (MG) With 1776 figs., 52 tabs [de

Imaging pelvic floor disorders. 2. rev. ed.

Energy Technology Data Exchange (ETDEWEB)

Stoker, Jaap [Amsterdam Univ. (Netherlands). Dept. of Radiology; Taylor, Stuart A. [University College Hospital, London (United Kingdom). Dept. of Specialist X-Ray; DeLancey, John O.L. (eds.) [Michigan Univ., Ann Arbor, MI (United States). L4000 Women' s Hospital

2008-07-01

This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

Interactions of the tropical oceans. Rev.ed.

International Nuclear Information System (INIS)

Latif, M.; Barnett, T.P.

1994-01-01

We have investigated the interactions of the tropical oceans on interannual time scales by conducting a series of uncoupled atmospheric and oceanic general circulation experiments and hybrid coupled model simulations. Our results illustrate the key role of the El Nino/Southern Oscillation (ENSO) phenomenon in generating interannual variability in all three tropical ocean basins. Sea surface temperature (SST) anomalies in the tropical Pacific force via a changed atmospheric circulation SST anomalies of the same sign in the Indian Ocean and SST anomalies of the opposite sign in the Atlantic. However, although air-sea interactions in the Indian and Atlantic Oceans are much weaker than those in the Pacific, they contribute significantly to the variability in these two regions. The role of these air-sea interactions is mainly that of an amplifyer by which the ENSO induced signals are enhanced in ocean and atmosphere. This process is particularly important in the tropical Atlantic region. We investigated also whether ENSO is part of a zonally propagating ''wave'' which travels around the globe with a time scale of several years. Consistent with observations, the upper ocean heat content in the various numerical simulations seems to propagate slowly around the globe. SST anomalies in the Pacific Ocean introduce a global atmospheric response which in turn forces variations in the other tropical oceans. Since the different oceans exhibit different response characteristics to low-frequency wind changes, the individual tropical ocean responses can add up coincidentally to look like a global wave, and that appears to be the situation. In particular, no evidence is found that the Indian Ocean can significantly affect the ENSO cycle in the Pacific. Finally, the potential for climate forecasts in the Indian and Atlantic Oceans appears to be enhanced if one includes, in a coupled way, remote influences from the Pacific. (orig.)

Environmental law. 6. rev. and enlarged ed.

International Nuclear Information System (INIS)

1991-01-01

This pocketbook contains major federal regulation on environmental protection. They serve to protect and cultivate mankind's natural foundations of life, to preserve the environment. The environments law is devided as follows: Constitutional law on the environment. Common administative law on the environment, special administrative law on the environment including conservation of nature and preservation of rural amenities, protection of waters waste management, protection against nuisances, nuclear energy are radiation protection, energy conservation, protection against dangerous substances, private law relating to the environment, criminal law relating to the environment. The transitional provisons required for estaslishing the unified Germany are given in an annex. (orig.) [de

Radiology. 3. rev. and enl. ed.; Radiologie

Energy Technology Data Exchange (ETDEWEB)

Reiser, Maximilian [Klinikum der Universitaet Muenchen (Germany). Inst. fuer Klinische Radiologie; Kuhn, Fritz-Peter [Klinikum Kassel (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Debus, Juergen [Radiologische Universitaetsklinik, Heidelberg (Germany). Abt. Radioonkologie und Strahlentherapie

2011-07-01

The text book on radiology covers the following issues: Part A: General radiology: Fundamental physics: radiation biology; radiation protection fundamentals: radiologic methods; radiotherapy; nuclear medicine. Part B: Special radiology: Thorax; heart; urogenital tract and retroperitoneum; vascular system and interventional radiology; esophagus, stomach, small and large intestines; liver, biliary system, pancreas and spleen; mammary glands; central nervous system; spinal cord and spinal canal; basis of the skull, facial bones and eye socket; neck; pediatric imaging diagnostics.

Operating Manual of Helium Refrigerator (Rev. 2)

Energy Technology Data Exchange (ETDEWEB)

Song, K.M.; Son, S.H.; Kim, K.S.; Lee, S.K.; Kim, M.S. [Korea Electric Power Research Institute, Taejon (Korea)

2002-07-01

A helium refrigerator was installed as a supplier of 20K cold helium to the cryogenic distillation system of WTRF pilot plant. The operating procedures of the helium refrigerator, helium compressor and auxiliary apparatus are described for the safety and efficient operation in this manual. The function of the helium refrigerator is to remove the impurities from the compressed helium of about 250psig, to cool down the helium from ambient temperature to 20K through the heat exchanger and expansion engine and to transfer the cold helium to the cryogenic distillation system. For the smoothly operation of helium refrigerator, the preparation, the start-up, the cool-down and the shut-down of the helium refrigerator are described in this operating manual. (author). 3 refs., 14 tabs.

A systematic study of odd-odd Gallium nuclei

International Nuclear Information System (INIS)

Allegro, P.R.P.; Medina, N.H.; Oliveira, J.R.B.; Ribas, R.V.; Cybulska, E.W.; Seale, W.A.; Zagatto, V.A.B.; Zahn, G.S.; Genezini, F.A.; Silveira, M.A.G.; Tabor, S.; Bender, P.; Tripathi, V.; Baby, L.

2012-01-01

Full text: Recently, many studies have been published attempting to explain the role of the 0g 9/2 orbital in the high spin excited states of nuclei in the region of the mass A=50-80, especially very neutron rich nuclei like, for example 59-66 Fe [1], 65,67 Cu [2], 70,80 Ge [3,4] nuclei and those with odd mass number like As, Ge and Ga [5]. Stefanescu et al. [6] demonstrated the presence of bands in the neutron-rich isotopes Ga formed from excitation of a proton to the 0g 9/2 orbital and Cheal et al. [7] revealed, from the study of the spins and moments of the ground state, changes in nuclear structure of the odd Ga isotopes between N = 40 and N 50, indicating a change in the energy gap between the 0g 9/2 orbital and the pf shell. In this work, we have performed a systematic study of odd-odd 64,66,68,70 Ga nuclei to examine the behavior of the 0g 9/2 orbital with an increasing number of neutrons. We have compared the predictions of the Large Scale Shell Model, obtained using the Antoine code [8] with the FPG [9] and JUN45 [10] effective interactions, with the experimental results obtained with in-beam gamma-ray spectroscopy experiments performed at University of Sao Paulo using SACI-PERERE spectrometer and at Florida State University using the Clover Array System. We have also performed calculations to study 67 Ge, an odd nucleus in the same mass region, in order to verify the behavior of the effective interactions in a nucleus without the proton-neutron interaction. [1] S. Lunardi. et al., Phys. Rev. C 76, 034303 (2007). [2] C. J. Chiara et al., Phys. Rev. C 85, 024309 (2012). [3] M. Sugawara et al., Phys. Rev. C 81, 024309 (2010). [4] H. Iwasaki.et al., Phys. Rev. C 78, 021304(R) (2008). [5] N. Yoshinaga et al. Phys. Rev. C 78, 044320 (2008). [6] I. Stefanescu et al., Phys. Rev. C 79, 064302 (2009). [7] B. Cheal et al. Phys. Rev. Lett. 104, 252502 (2010). [8] E. Caurier and F. Nowacki, Acta Phys. Polonica B 30, 705 (1999). [9] O. Sorlin et al., Phys. Rev. Lett

Travelling-wave amplitudes as solutions of the phase-field crystal equation

Science.gov (United States)

Nizovtseva, I. G.; Galenko, P. K.

2018-01-01

The dynamics of the diffuse interface between liquid and solid states is analysed. The diffuse interface is considered as an envelope of atomic density amplitudes as predicted by the phase-field crystal model (Elder et al. 2004 Phys. Rev. E 70, 051605 (doi:10.1103/PhysRevE.70.051605); Elder et al. 2007 Phys. Rev. B 75, 064107 (doi:10.1103/PhysRevB.75.064107)). The propagation of crystalline amplitudes into metastable liquid is described by the hyperbolic equation of an extended Allen-Cahn type (Galenko & Jou 2005 Phys. Rev. E 71, 046125 (doi:10.1103/PhysRevE.71.046125)) for which the complete set of analytical travelling-wave solutions is obtained by the method (Malfliet & Hereman 1996 Phys. Scr. 15, 563-568 (doi:10.1088/0031-8949/54/6/003); Wazwaz 2004 Appl. Math. Comput. 154, 713-723 (doi:10.1016/S0096-3003(03)00745-8)). The general solution of travelling waves is based on the function of hyperbolic tangent. Together with its set of particular solutions, the general solution is analysed within an example of specific task about the crystal front invading metastable liquid (Galenko et al. 2015 Phys. D 308, 1-10 (doi:10.1016/j.physd.2015.06.002)). The influence of the driving force on the phase-field profile, amplitude velocity and correlation length is investigated for various relaxation times of the gradient flow. This article is part of the theme issue `From atomistic interfaces to dendritic patterns'.

Robust entangled qutrit states in atmospheric turbulence

CSIR Research Space (South Africa)

Brunner, T

2013-06-01

Full Text Available of two qubits. Phys. Rev. Lett., 80:2245–2248, 1998. [17] F. Mintert, M. Kus´, and A. Buchleitner. Concurrence of mixed bipartite quantum states in arbitrary dimensions. Phys. Rev. Lett., 92:167902, 2004. ...

Although South African sardine (or pilchard, Sardinops sagax) were ...

African Journals Online (AJOL)

spamer

was based on assumed reliability of the hydroacoustic estimates of ... of uncertainties about the value of natural mortality) .... TAC only) also to the estimate of sardine recruitment from the ... of sardine recruitment from that survey: rev ad rev.

Rediscovered and new perisphaerine cockroaches from SW China with a review of subfamilial diagnosis (Blattodea: Blaberidae).

Science.gov (United States)

Li, Xin-Ran; Wang, Li-Li; Wang, Zong-Qing

2018-04-17

The taxonomic records of Chinese perisphaerine cockroaches were scattered in literature, and therefore a dedicated study is desired to update our knowledge. This paper reviews the subfamilial diagnosis and Chinese species, mostly from southwestern China. We provide high-definition habitus photos and drawings, the latter emphasizes the genitalia of both sexes, which are generalized with diagrams, abstracted from specimens examined. A total of 18 species are recorded in four genera, including Perisphaerus, or pill cockroach, the type genus of the subfamily. Two new genera and three new species are proposed: Achatiblatta achates gen. sp. nov., Frumentiforma frumentiformis gen. sp. nov., and Pseudoglomeris montana sp. nov.. Pseudoglomeris has five new junior synonyms: Corydidarum, Trichoblatta, Kurokia, Glomerexis, and Glomeriblatta; the following combinations are thus revived or new: Ps. aerea comb. nov., Ps. angustifolia comb. nov., Ps. beybienkoi comb. nov., Ps. fallax comb. nov., Ps. magnifica comb. rev., Ps. montshadskii comb. nov., Ps. nigra comb. nov., Ps. sculpta comb. nov., Ps. semisulcata comb. rev., Ps. tibetana comb. nov., and Ps. valida moderata comb. nov.. The following species are revalidated and combinations revived: Pe. pygmaeus comb. rev., Ps. dubia comb. sp. rev., and Ps. planiuscla comb. sp. rev.

Indications for an inducible component of error-prone DNA repair in yeast

International Nuclear Information System (INIS)

Siede, W.; Eckardt, F.

1984-01-01

In a thermoconditional mutant of mutagenic DNA repair (rev 2sup(ts) = rad5-8) of Saccharomyces cerevisiae recovery of survival and mutation frequencies can be monitored by incubating UV-irradiated cells in growth medium at a permissive temperature (23 0 C) before plating and a shift to restrictive temperature (36 0 C). Inhibition of protein synthesis with cycloheximide during incubation at permissive conditions blocks this REV 2 dependent recovery process in stationary phase rev 2sup(ts) cells, whereas it can be reduced but not totally abolished in exponentially growing cells. These results indicate a strict dependence on post-irradiation protein synthesis in stationary phase cells and argue for a considerable constitutive level and only limited inducibility in logarithmic phase cells. The UV inducibility of the REV 2 coded function in stationary phase cells could be confirmed by analysis of dose-response pattern of the his 5-2 reversion: in stationary phase rev 2sup(ts) cells, the quadratic component of the biphasic linear-quadratic induction kinetics found at 23 0 C, which is interpreted as the consequence of induction of mutagenic repair, is eliminated at 36 0 C. (author)

Indications for an inducible component of error-prone DNA repair in yeast.

Science.gov (United States)

Siede, W; Eckardt, F

1984-01-01

In a thermoconditional mutant of mutagenic DNA repair (rev 2ts = rad 5-8) of Saccharomyces cerevisiae recovery of survival and mutation frequencies can be monitored by incubating UV-irradiated cells in growth medium at a permissive temperature (23 degrees C) before plating and a shift to restrictive temperature (36 degrees C). Inhibition of protein synthesis with cycloheximide during incubation at permissive conditions blocks this REV 2 dependent recovery process in stationary phase rev 2ts cells, whereas it can be reduced but not totally abolished in exponentially growing cells. These results indicate a strict dependence on post-irradiation protein synthesis in stationary phase cells and argue for a considerable constitutive level and only limited inducibility in logarithmic phase cells. The UV inducibility of the REV 2 coded function in stationary phase cells could be confirmed by analysis of the dose-response pattern of the his 5-2 reversion: in stationary phase rev 2ts cells, the quadratic component of the biphasic linear-quadratic induction kinetics found at 23 degrees C, which is interpreted as the consequence of induction of mutagenic repair, is eliminated at 36 degrees C.

N-body simulations for f(R) gravity using a self-adaptive particle-mesh code

Science.gov (United States)

Zhao, Gong-Bo; Li, Baojiu; Koyama, Kazuya

2011-02-01

We perform high-resolution N-body simulations for f(R) gravity based on a self-adaptive particle-mesh code MLAPM. The chameleon mechanism that recovers general relativity on small scales is fully taken into account by self-consistently solving the nonlinear equation for the scalar field. We independently confirm the previous simulation results, including the matter power spectrum, halo mass function, and density profiles, obtained by Oyaizu [Phys. Rev. DPRVDAQ1550-7998 78, 123524 (2008)10.1103/PhysRevD.78.123524] and Schmidt [Phys. Rev. DPRVDAQ1550-7998 79, 083518 (2009)10.1103/PhysRevD.79.083518], and extend the resolution up to k˜20h/Mpc for the measurement of the matter power spectrum. Based on our simulation results, we discuss how the chameleon mechanism affects the clustering of dark matter and halos on full nonlinear scales.

Structural study of SiC(0 0 0 1)3x3 surface by surface X-ray diffraction

International Nuclear Information System (INIS)

Aoyama, T.; Akimoto, K.; Ichimiya, A.; Hisada, Y.; Mukainakano, S.; Emoto, T.; Tajiri, H.; Takahashi, T.; Sugiyama, H.; Zhang, X.; Kawata, H.

2003-01-01

Surface structure of 6H-SiC(0 0 0 1)3x3 reconstruction has been studied by grazing incidence X-ray diffraction with synchrotron radiation. We compared the Patterson map obtained from experimental structure factors with calculated Patterson maps estimated from the models that had been proposed. As the result, the calculated Patterson maps of Kulakov et al.'s [Surf. Sci. 346 (1996) 49] and Starke and coworkers' models [Phys. Rev. Lett. 80 (1998) 758; Phys. Rev. B 58 (1998) 10806; Surf. Rev. Lett. 6 (1999) 1129; Appl. Surf. Sci. 162-163 (2000) 9; Phys. Rev. B 62 (2000) 10335] are relatively in good agreement with experimental one. Therefore, we conclude that there is high possibility that either Kulakov et al.'s or Starke and coworkers' models are reasonable as the actual 3x3 structure

High-energy behavior of the double photoionization of helium from 2 to 12 keV

International Nuclear Information System (INIS)

Levin, J.C.; Sellin, I.A.; Johnson, B.M.; Lindle, D.W.; Miller, R.D.; Berrah, N.; Azuma, Y.; Berry, H.G.; Lee, D.

1993-01-01

We report the ratio of double-to-single photoionization of He at several photon energies from 2 to 12 keV. By time-of-flight methods, we find a ratio consistent with an asymptote at 1.5%±0.2%, essentially reached by hν∼4 keV. Fair agreement is obtained with older shake calculations of Byron and Joachain [Phys. Rev. 164, 1 (1967)], of Aberg [Phys. Rev. A 2, 1726 (1970)], and with recent many-body perturbation theory (MBPT) of Ishihara, Hino, and McGuire [Phys. Rev. A 44, 6980 (1991)]. The result lies below earlier MPBT calculations by Amusia et al. [J. Phys. B 8, 1248 (1975)] (2.3%), and well above semiempirical predictions of Samson [Phys. Rev. Lett. 65, 2861 (1990)], who expects no asymptote and predicts σ(He 2+ )/σ(He + )=0.3% at 12 keV

Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

Energy Technology Data Exchange (ETDEWEB)

Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

2010-12-29

This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

Dicty_cDB: Contig-U12531-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available SHGC-CLJ Gasterosteus aculeatus ... 48 0.77 1 ( EY497720 ) CBBP3718.rev CBBP Hirudo medicinalis hermaphrodi...t... 48 0.77 1 ( EY496316 ) CBBP2847.fwd CBBP Hirudo medicinalis hermaphrodit... 48 0.77 1 ( EY496315 ) CBBP2847.rev CBBP Hirudo medi...cinalis hermaphrodit... 48 0.77 1 ( EY484422 ) CBBP13571.fwd CBBP Hirudo medicina...lis hermaphrodi... 48 0.77 1 ( EY484421 ) CBBP13571.rev CBBP Hirudo medicinalis her...maphrodi... 48 0.77 1 ( EY483641 ) CBBP13100.fwd CBBP Hirudo medicinalis hermaphrodi... 48 0.77 1 ( EY483640

Improved adsorption energetics within density-functional theory using revised Perdew-Burke-Ernzerhof functionals

DEFF Research Database (Denmark)

Hammer, Bjørk; Hansen, Lars Bruno; Nørskov, Jens Kehlet

1999-01-01

A simple formulation of a generalized gradient approximation for the exchange and correlation energy of electrons has been proposed by Perdew, Burke, and Ernzerhof (PBE) [Phys. Rev. Lett. 77, 3865 (1996)]. Subsequently Zhang and Yang [Phys. Rev. Lett. 80, 890 (1998)] have shown that a slight...... revision of the PBE functional systematically improves the atomization energies for a large database of small molecules. In the present work, we show that the Zhang and Yang functional (revPBE) also improves the chemisorption energetics of atoms and molecules on transition-metal surfaces. Our test systems...

Symbolika barev v Apokalypse

OpenAIRE

Seidlová, Kateřina

2008-01-01

Anglická anotace Symbolic Colours in the Apocalypse of Saint John This thesis attempts to study the use of colours in the depiction of certain themes in the Apocalypse of st. John. The colours used by the author of Revelation are taken both from apocalyptic literature of the Old Testament era, but mainly from the books of Daniel, Ezechiel, Zacharias and Joel. The most often used colour is white: the white stone (Rev 2,17); the white cloud (Rev 14,14); the white horse (Rev 19,11); the white th...

25MM Plastic Telescoped Cartridge Case Development Program

Science.gov (United States)

1975-01-01

Mat’ I____ Projectile: 0wq. No. 30033;7,Rev, A, Platic "Band, 3000 Grain. Primer: Type .SmL. , Lot No.,, , Ne. . Flash Tubet.l3TSpe 1ell Project l...8217 _ ’_"__ Projectile: Dwg. No. 300347, Ray. A, Platic Biand, 3000 Graln. Primer: Type P-SIT.ML , Lot No. . No, Flash Tube:c<# 7’Tr-pecla1, Projectile Rot ntlo...Case: N ,o Rev. ___, Mati:.l, ILt Dwg. No,._____ Rev. M Nt l______Projectile: Dwg, No. 300347, ev • A, Platic ’ t -and, 3000 Grain, Primers Type , Lot

International Conference on the Physics of Electronic and Atomic Collisions (14th) Held in Palo Alto, California on 24-30 July 1985 (Electronic and Atomic Collisions. Invited Papers)

Science.gov (United States)

1985-07-30

76] A. Zastawny, Acta . Phys. Polonica , A46 (1974) 39. 77] R. GrUnberg, Z. Naturforsch., A24 (169) 1039. 78] R. Grnberg, Z. Naturforsch., A 3 (1978...Rev. A12 (1975) 1825. 24) A.K. Pradhan, Phys. Rev. Lett. 32 (1983) 84. 47 (1981) 79. 25) Jia-Ming Li(C.M. Lee), Acta Physica Sinica 32 (1983) 84. 26...1985) XXX. 33) H. Bethe, Ann. Physik 5(1930) 325. 34) M. Inokuti, Rev. Mod. Phys. 43 (1971) 279. 35) Bo-Cang Tian, Jia-Ming Li(C.M. Lee), Acta Physica

Link between structural and mechanical stability of fcc- and bcc-based ordered MgeLi alloys

CSIR Research Space (South Africa)

Phasha, MJ

2010-06-01

Full Text Available ) pseudopotential method, embodied in the CASTEP code [10]. The Hohenberg-Kohn-Sham density functional theory (DFT) [11] was used 5 within the GGA formalism [12] to describe the electronic exchange-correlation interactions. We used the recent PBE form..., Int. J. Quantum Chem. 77 (2000) 895. [11] P. Hohenberg and W. Kohn, Phys. Rev. 136, B 864 (1964), W. Kohn and L.J. Sham, Phys. Rev. 140 (1965) A 1133. [12] J.P. Perdew and Y. Wang, Phys. Rev. B 45 (1992) 13244. [13] J.P. Perdew, K. Burke and M...

Dicty_cDB: Contig-U04644-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available pic... 44 2.2 1 ( EY502549 ) CBBP6429.rev CBBP Hirudo medicinalis hermaphrodit... 44 2.2 1 ( EY484983 ) CBBP14303.rev CBBP Hirudo med...icinalis hermaphrodi... 44 2.2 1 ( AM180255 ) Lawsonia i

Living coccolithophorids from the Arabian Sea

Digital Repository Service at National Institute of Oceanography (India)

Guptha, M.V.S.; Mohan, R.; Muralinath, A.S.

stream_size 23 stream_content_type text/plain stream_name Rev_Ital_Paleontol_Stratigr_100_551.pdf.txt stream_source_info Rev_Ital_Paleontol_Stratigr_100_551.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

Positioning and surveying requirements for exploration and exploitation of ocean wealth

Digital Repository Service at National Institute of Oceanography (India)

Pathak, M.C.; Kotnala, K.L.; Prabaharan, N.; Ganesan, P.

stream_size 9 stream_content_type text/plain stream_name Int_Hydrogr_Rev_67_93.pdf.txt stream_source_info Int_Hydrogr_Rev_67_93.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

Dicty_cDB: Contig-U10820-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 107.fwd CBHU Mycosphaerella fijiensis MfEST3... 54 2e-05 2 ( FD673984 ) CBHU3107....rev CBHU Mycosphaerella fijiensis MfEST3... 54 2e-05 2 ( FD672075 ) CBHU2044.rev CBHU Mycosphaerella fijiens

Dicty_cDB: Contig-U15415-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available BHX5888.fwd CBHX Mycosphaerella fijiensis MfEST4... 46 8.1 1 ( FD686821 ) CBHX5888.rev CBHX Mycosphaerella fiji...ensis MfEST4... 46 8.1 1 ( FD686533 ) CBHX5748.rev CBHX Mycosphaerella fijiens

A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization

International Nuclear Information System (INIS)

Gonzalez, P.; Massardo, T.; Coll, C.; Redondo, F.; Jofre, J.; Redondo, F.; Sierralta, P.; Humeres, P.; Yovanovich, J.; Chamorro, H.

2002-01-01

Aim: To compare the extension and severity in perfusion, glucose metabolism and contractility abnormalities in recent myocardial infarction, assessed by different imaging modalities, and to evaluate these functional parameters in patients with and without revascularization (REV). Materials and methods: We assessed 49 patients with a first MI (58 ±12 years; 82 % males) using 1) [Tl201] rest SPECT, 2) [Tl201] redistribution (red) SPECT, 3) [F18]FDG SPECT and 4) 2D echocardiograms at a mean of 9.2 days, range: 1-24; 29 (59%) patients had been REV by means of PTCA or CABG and 20 (41%) underwent only medical therapy. All had angiogram. Images were analyzed blindly, employing the same polar map which included 17 segments in the four sets of studies. Both, the number of segments involved and their severity (normal, mild, moderate or markedly abnormal) using a semiquantitative score from 1 to 4 were tabulated. Results: In the total group (n=833 segments), the abnormal segments in echo were 302 (36%), in Tl rest 231 (28%), in Tl red 223 (26%) and in FDG 202 (24%), (p<0.001 echo vs all other). Regarding severity score, the median (s.d.) values were: 2.6 (0.5); 2.9 (0.9); 2.8 (1.2) and 2.9 (1.2), respectively (p<0.01 echo vs all other). In REV patients (n=493), the lesion size was 154 segments (31%), 116 (23%), 112 (23%) and 100 (20%), respectively. In those without REV (n=340) the number of abnormal segments were 148 (44%), 115 (34%), 111 (33%) and 102 (30%) respectively (p<0.004, REV vs no REV). McNemar, Student t tests were used in the comparisons. Conclusion: In recent MI, echo abnormalities were bigger in size (up to 13%) than the perfusion and metabolic defects, but less severe (down to 10%) compared to radionuclide procedures, possibly due to stunning. Non REV patients presented with greater extension (up to 11%) and more severity (up to 22%) than REV ones in any of the imaging modalities, explained by therapy effect. Both, echo and radionuclide techniques appear

A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization

Energy Technology Data Exchange (ETDEWEB)

Gonzalez, P [Department of Nuclear Medicine of the University of Chile Clinical Hospital (Chile); Department of Nuclear Medicine of Santa Maria Clinic (Chile); Massardo, T; Coll, C; Redondo, F; Jofre, J; Sierralta, P [Department of Nuclear Medicine of the University of Chile Clinical Hospital (Chile); Humeres, P [Department of Nuclear Medicine of Santa Maria Clinic (Chile); Yovanovich, J [Cardiovascular Center of the University of Chile Clinical Hospital (Chile); Chamorro, H [Cardiovascular Center of Santa Maria Clinic, Santiago (Chile)

2002-09-01

Aim: To compare the extension and severity in perfusion, glucose metabolism and contractility abnormalities in recent myocardial infarction, assessed by different imaging modalities, and to evaluate these functional parameters in patients with and without revascularization (REV). Materials and methods: We assessed 49 patients with a first MI (58 {+-}12 years; 82 % males) using 1) [Tl201] rest SPECT, 2) [Tl201] redistribution (red) SPECT, 3) [F18]FDG SPECT and 4) 2D echocardiograms at a mean of 9.2 days, range: 1-24; 29 (59%) patients had been REV by means of PTCA or CABG and 20 (41%) underwent only medical therapy. All had angiogram. Images were analyzed blindly, employing the same polar map which included 17 segments in the four sets of studies. Both, the number of segments involved and their severity (normal, mild, moderate or markedly abnormal) using a semiquantitative score from 1 to 4 were tabulated. Results: In the total group (n=833 segments), the abnormal segments in echo were 302 (36%), in Tl rest 231 (28%), in Tl red 223 (26%) and in FDG 202 (24%), (p<0.001 echo vs all other). Regarding severity score, the median (s.d.) values were: 2.6 (0.5); 2.9 (0.9); 2.8 (1.2) and 2.9 (1.2), respectively (p<0.01 echo vs all other). In REV patients (n=493), the lesion size was 154 segments (31%), 116 (23%), 112 (23%) and 100 (20%), respectively. In those without REV (n=340) the number of abnormal segments were 148 (44%), 115 (34%), 111 (33%) and 102 (30%) respectively (p<0.004, REV vs no REV). McNemar, Student t tests were used in the comparisons. Conclusion: In recent MI, echo abnormalities were bigger in size (up to 13%) than the perfusion and metabolic defects, but less severe (down to 10%) compared to radionuclide procedures, possibly due to stunning. Non REV patients presented with greater extension (up to 11%) and more severity (up to 22%) than REV ones in any of the imaging modalities, explained by therapy effect. Both, echo and radionuclide techniques appear

Boron-Dipyrromethene Dyes for Ion Recognition Studies

Indian Academy of Sciences (India)

pc

Singlet state energy levels of porphyrins with various cores λ abs ... Chem. Rev. 250, 468 (2006). M. Yedukondalu, M. Ravikanth, Coord. Chem. Rev. 255, 547 ..... 525 550 575 600 625 650 675 700 725 750. 0. 200. 400. 600. 800. 1000. 580.

ADMINISTRATIVE CIRCULARS

CERN Multimedia

Division des ressources humaines

2000-01-01

N° 2 (Rev. 1) - March 2000Guidelines and procedures concerning recruitment and probation period of staff membersN° 9 (Rev. 2) - March 2000Staff members contractsN° 16 (Rev. 2) - January 2000TrainingN° 30 (Rev. 1) - January 2000Indemnities and reimbursements upon taking up appointment and termination of contractN° 32 - February 2000Principles and procedures governing complaints of harassmentThese circular have been amended (No 2, N° 9, N° 16 and N° 30) or drawn up (N° 32).Copies are available in the Divisional Secretariats.Note:\tAdministrative and operational circulars, as well as the lists of those in force, are available for consultation in the server SRV4_Home in the Appletalk zone NOVELL (as GUEST or using your Novell username and password), volume PE Division Data Disk.The Word files are available in the folder COM, folder Public, folder ADM.CIRC.docHuman Resources DivisionTel. 74128

Estimation of shear viscosity based on transverse momentum correlations

International Nuclear Information System (INIS)

Sharma, Monika

2009-01-01

Event anisotropy measurements at RHIC suggest the strongly interacting matter created in heavy ion collisions flows with very little shear viscosity. Precise determination of 'shear viscosity-to-entropy' ratio is currently a subject of extensive study [S. Gavin and M. Abdel-Aziz, Phys. Rev. Lett. 97 (2006) 162302]. We present preliminary results of measurements of the evolution of transverse momentum correlation function with collision centrality of Au+Au interactions at √(s NN )=200 GeV. We compare two differential correlation functions, namely inclusive [J. Adams et al. (STAR Collaboration), Phys. Rev. C 72 (2005) 044902] and a differential version of the correlation measure C introduced by Gavin et al. [S. Gavin and M. Abdel-Aziz, Phys. Rev. Lett. 97 (2006) 162302; M. Sharma and C. A. Pruneau, Phys. Rev. C 79 (2009) 024905.]. These observables can be used for the experimental study of the shear viscosity per unit entropy.

Estimation of shear viscosity based on transverse momentum correlations

Science.gov (United States)

STAR Collaboration; Sharma, Monika; STAR Collaboration

2009-11-01

Event anisotropy measurements at RHIC suggest the strongly interacting matter created in heavy ion collisions flows with very little shear viscosity. Precise determination of “shear viscosity-to-entropy” ratio is currently a subject of extensive study [S. Gavin and M. Abdel-Aziz, Phys. Rev. Lett. 97 (2006) 162302]. We present preliminary results of measurements of the evolution of transverse momentum correlation function with collision centrality of Au+Au interactions at s=200 GeV. We compare two differential correlation functions, namely inclusive [J. Adams et al. (STAR Collaboration), Phys. Rev. C 72 (2005) 044902] and a differential version of the correlation measure C˜ introduced by Gavin et al. [S. Gavin and M. Abdel-Aziz, Phys. Rev. Lett. 97 (2006) 162302; M. Sharma and C. A. Pruneau, Phys. Rev. C 79 (2009) 024905.]. These observables can be used for the experimental study of the shear viscosity per unit entropy.

Standing Concertation Committee

CERN Document Server

HR Department

2008-01-01

ORDINARY MEETING ON 27 FEBRUARY 2008 The main items discussed at the meetings of the Standing Concertation Committee on 27 February 2008 included: Short-term Saved Leave Scheme The Committee noted that, by the end of February 2008, some 600 staff had enrolled in the short-term saved leave scheme: approx. 58% had signed up for 1 slice, 14% for two slices, 5% for three slices and 23% for four slices. Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme The Committee agreed to recommend the Director-General to approve Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme. Administrative Circular No. 30 (Rev. 2) - Financial benefits upon taking up appointment and termination of contract The Committee agreed to recommend the Director-General to approve Administrative Circular No. 30 (Rev. 2) - Financial Benefits upon taking up appointment and termination of contract. Progressive Retirement Programme The Progressive Retirement Programme (PR...

Exploratory study of fission product yields of neutron-induced fission of 235U , 238U , and 239Pu at 8.9 MeV

Science.gov (United States)

Bhatia, C.; Fallin, B. F.; Gooden, M. E.; Howell, C. R.; Kelley, J. H.; Tornow, W.; Arnold, C. W.; Bond, E.; Bredeweg, T. A.; Fowler, M. M.; Moody, W.; Rundberg, R. S.; Rusev, G. Y.; Vieira, D. J.; Wilhelmy, J. B.; Becker, J. A.; Macri, R.; Ryan, C.; Sheets, S. A.; Stoyer, M. A.; Tonchev, A. P.

2015-06-01

Using dual-fission chambers each loaded with a thick (200 -400 -mg /c m2) actinide target of 235 ,238U or 239Pu and two thin (˜10 -100 -μ g /c m2) reference foils of the same actinide, the cumulative yields of fission products ranging from 92Sr to 147Nd have been measured at En= 8.9 MeV . The 2H(d ,n ) 3He reaction provided the quasimonoenergetic neutron beam. The experimental setup and methods used to determine the fission product yield (FPY) are described, and results for typically eight high-yield fission products are presented. Our FPYs for 235U(n ,f ) , 238U(n ,f ) , and 239Pu(n ,f ) at 8.9 MeV are compared with the existing data below 8 MeV from Glendenin et al. [Phys. Rev. C 24, 2600 (1981), 10.1103/PhysRevC.24.2600], Nagy et al. [Phys. Rev. C 17, 163 (1978), 10.1103/PhysRevC.17.163], Gindler et al. [Phys. Rev. C 27, 2058 (1983), 10.1103/PhysRevC.27.2058], and those of Mac Innes et al. [Nucl. Data Sheets 112, 3135 (2011), 10.1016/j.nds.2011.11.009] and Laurec et al. [Nucl. Data Sheets 111, 2965 (2010), 10.1016/j.nds.2010.11.004] at 14.5 and 14.7 MeV, respectively. This comparison indicates a negative slope for the energy dependence of most fission product yields obtained from 235U and 239Pu , whereas for 238U the slope issue remains unsettled.

Diagnostic value of myocardial perfusion SPECT in the prediction of restenosis after coronary artery bypass graft surgery

International Nuclear Information System (INIS)

Paeng, J. C.; Lee, D. S.; Kang, W. J.; Kim, K. B.; Chung, J. K.; Lee, M. C.

2002-01-01

Myocardial SPECT has been reported to be sensitive in the detection of restenosis after revascularization. However, the diagnostic value is not well established in bypass graft surgery (CABG), due to significant influences of characteristics of graft vessels and the time interval between CABG and the SPECT. In this study, we evaluated the diagnostic value of myocardial SPECT for the restenosis after CABG. A total of 160 patients with coronary artery disease (M:F=118:42, 60±8 yr) who had undergone CABG were included. Rest T1-201/ dipyridamole stress Tc-99m-MIBI SPECT was performed 3 months (103±16 days) after CABG. Segmental perfusion was quantified using a 20-segment model, and segments of reversible perfusion defect (REV) were defined. Follow-up coronary angiography was performed 1 year (397±104 days) after CABG. The segments of REV were compared between arterial and venous graft groups. And the diagnostic power of 3-month SPECT was evaluated for the prediction of restenosis. On the 3-month SPECT, 620 segments showed REV. The segments of REV were 37% of artery-grafted segments and 36% of vein-grafted segments (p=n.s.). On 1-year coronary angiography, 113 graft vessels (28%) showed restenosis. The overall sensitivity and specificity of REV on 3-month SPECT for the prediction of restenosis were 46% and 67%, respectively, but 52% and 68%, in artery-graft group. REV detected on 3-month SPECT has a predictive value, especially, high specificity for the prediction of restenosis after CABG, which was more definite in artery-graft group

Assessment of the GLLB-SC potential for solid-state properties and attempts for improvement

Science.gov (United States)

Tran, Fabien; Ehsan, Sohaib; Blaha, Peter

2018-02-01

Based on the work of Gritsenko et al. (GLLB) [Phys. Rev. A 51, 1944 (1995), 10.1103/PhysRevA.51.1944], the method of Kuisma et al. [Phys. Rev. B 82, 115106 (2010), 10.1103/PhysRevB.82.115106] to calculate the band gap in solids was shown to be much more accurate than the common local density approximation (LDA) and generalized gradient approximation (GGA). The main feature of the GLLB-SC potential (SC stands for solid and correlation) is to lead to a nonzero derivative discontinuity that can be conveniently calculated and then added to the Kohn-Sham band gap for a comparison with the experimental band gap. In this work, a thorough comparison of GLLB-SC with other methods, e.g., the modified Becke-Johnson (mBJ) potential [Tran and Blaha, Phys. Rev. Lett. 102, 226401 (2009), 10.1103/PhysRevLett.102.226401], for electronic, magnetic, and density-related properties is presented. It is shown that for the band gap, GLLB-SC does not perform as well as mBJ for systems with a small band gap and strongly correlated systems, but is on average of similar accuracy as hybrid functionals. The results on itinerant metals indicate that GLLB-SC overestimates significantly the magnetic moment (much more than mBJ does), but leads to excellent results for the electric field gradient, for which mBJ is in general not recommended. In the aim of improving the results, variants of the GLLB-SC potential are also tested.

Understanding metal–insulator transition in sodium tungsten bronze

Indian Academy of Sciences (India)

, A Chakraborty, D D Sarma, P Mahadevan, S. Oishi, W H McCarroll and M Greenblatt, Phys. Rev. B 75, 155116 (2007). [17] S Raj, A Chakraborty, D Choudhury, T Sato, T Takahashi, P Mahadevan, J Fujii, I Vobornik and D D Sarma, Phys. Rev.

Dicty_cDB: Contig-U15212-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available I Pichia stipitis aerobic dextrose... 46 3e-04 2 ( FE846176 ) CAFI593.rev CAFI Pichia stipitis aerobic dextrose...529.fwd CAFI Pichia stipitis aerobic dextrose... 46 3e-04 2 ( FE851967 ) CAFP1996.rev CAFP Pichia stipitis a

Dicty_cDB: Contig-U10237-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available rcoralis ... 48 8e-09 3 ( EY502913 ) CBBP6629.rev CBBP Hirudo medicinalis hermaphrodit... 42 2e-08 4 ( EY483...666 ) CBBP13113.rev CBBP Hirudo medicinalis hermaphrodi... 42 2e-08 4 ( EY481295 ...) CBBP11299.rev CBBP Hirudo medicinalis hermaphrodi... 42 2e-08 4 ( DC439626 ) Gryllus bimaculatus mRNA, clo...) 1323 Sminthopsis fibroblast Library Sminthopsis c... 42 4e-06 3 ( EY505088 ) CBBP9613.fwd CBBP Hirudo medicina...lis hermaphrodit... 42 9e-06 3 ( EY483667 ) CBBP13113.fwd CBBP Hirudo medicinalis hermaphrodi... 42 9e-0

Dicty_cDB: Contig-U06413-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available rus EST library project... 48 0.34 1 ( EY496038 ) CBBP2673.rev CBBP Hirudo medicinalis hermaphrodit... 48 0....34 1 ( EY493522 ) CBBP19513.fwd CBBP Hirudo medicinalis hermaphrodi... 48 0.34 1 ( EY491706 ) CBBP18426.fwd CBBP Hirudo medicina...lis hermaphrodi... 48 0.34 1 ( EY491705 ) CBBP18426.rev CBBP Hirudo medicina...lis hermaphrodi... 48 0.34 1 ( EY490129 ) CBBP17464.fwd CBBP Hirudo medicinalis hermaphrodi...... 48 0.34 1 ( EY485788 ) CBBP14812.fwd CBBP Hirudo medicinalis hermaphrodi... 48 0.34 1 ( EY485787 ) CBBP14812.rev CBBP Hirudo medici

Dicty_cDB: Contig-U01764-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available .. 44 1.4 1 ( EY870291 ) CL06-C4-500-044-E06-CT.F Rangpur lime root, green... 44 1.4 1 ( EY496941 ) CBBP3246.fwd CBBP Hirudo medicina...lis hermaphrodit... 44 1.4 1 ( EY493732 ) CBBP19624.rev CBBP Hirudo medicina...lis hermaphrodi... 44 1.4 1 ( EY488088 ) CBBP16209.fwd CBBP Hirudo medicinalis hermaphro...di... 44 1.4 1 ( EY488087 ) CBBP16209.rev CBBP Hirudo medicinalis hermaphrodi... 44 1.4 1 ( EY480105 ) CBBP10646.rev CBBP Hirudo medi...cinalis hermaphrodi... 44 1.4 1 ( EY345787 ) CAWZ14271.r

Communications dated 15 and 22 March 1994 received from the permanent mission of South Africa to the International Atomic Energy Agency

International Nuclear Information System (INIS)

1994-01-01

The Director General received notes verbales dated 15 and 22 March 1994 from the Permanent Mission of South Africa providing information on the nuclear export policies and practices of the Government of South Africa. These notes verbales contain, in their attachments, copies of the relevant legislation and other documentation pertaining to South Africa's policy to act in accordance with the provisions of INFCIRC/254/Rev.1/Part 1 and INFCIRC/254/Rev.1/Part 1/Mod.1 and INFCIRC/254/Rev.1/Part 2 as amended. The documents are available on request from the Secretariat of the IAEA

Comment on ‘Time delays in molecular photoionization’

Science.gov (United States)

Baykusheva, Denitsa; Wörner, Hans Jakob

2017-04-01

In a recent article by Hockett et al (2016 J. Phys. B: At. Mol. Opt. Phys. 49 095602), time delays arising in the context of molecular single-photon ionization are investigated from a theoretical point of view. We argue that one of the central equations given in this article is incorrect and present a reformulation that is consistent with the established treatment of angle-dependent scattering delays (Eisenbud 1948 PhD Thesis Princeton University; Wigner 1955 Phys. Rev. 98 145-7 Smith 1960 Phys. Rev. 118 349-6 Nussenzveig 1972 Phys. Rev. D 6 1534-42).

Obervations on the Induction of Position Effect Variegation of Euchromatic Genes in Drosophila Melanogaster

OpenAIRE

Pokholkova, G. V.; Makunin, I. V.; Belyaeva, E. S.; Zhimulev, I. F.

1993-01-01

In the T(1;2)dor(var7) translocation, the 1A-2B7-8 segment of the X chromosome is brought to the vicinity of 2R-chromosome heterochromatin resulting in position effect variegation of dor, BR-C and more distal genes, as well as compaction of chromatin in this segment. By irradiation of T(1;2)dor(var7), nine reversions (rev) to a normal phenotype were recovered. In two cases (rev27, rev226), the 1A-2B7-8 section is relocated to the 19A region of the X chromosome, forming free duplications (1A-2...

Absenteeism movement in Greater Poland in 1840–1902

Directory of Open Access Journals (Sweden)

Izabela Krasińska

2013-12-01

Full Text Available The article presents the origins and development of the idea of absenteeism in Greater Poland in the 19th century. The start date for the research is 1840, which is considered to be a breakthrough year in the history of an organized absenteeism movement in Greater Poland. It was due to the Association for the Suppression of the Use of Vodka (Towarzystwo ku Przytłumieniu Używania Wódki in the Great Duchy of Posen that was then established in Kórnik. It was a secular organization that came into being on an initiative of doctor De La Roch, who was a German surgeon of a French origin. However, as early as 1844, the idea of absenteeism raised an interest of catholic clergymen of Greater Poland with high ranking clergy such as Rev. Leon Michał Przyłuski, Archbishop of Gniezno and Rev. Jan Kanty Dąbrowski, Archbishop of Posen, and later on Archbishops Rev. Mieczysław Halka Ledóchowski and Rev. Florian Oksza Stablewski. They were fascinated with activities of Rev. Jan Nepomucen Fick, Parish Priest of Piekary Śląskie and several other priests on whose initiative a lot of church brotherhoods of so called holy continence were set up in Upper Silesia as early as the first half-year of 1844. It was due to Bishop Dąbrowski that 100 000 people took vows of absenteeism in 1844–1845, becoming members of brotherhoods of absenteeism. In turn, it was an initiative of Archbishop Przyłuski that Jesuit missionaries – Rev. Karol Bołoz Antoniewicz, Rev. Teofil Baczyński and Rev. Kamil Praszałowicz, arrived in Greater Poland from Galicia in 1852 to promote the idea of absenteeism. Starting from 1848, they were helping Silesian clergymen to spread absenteeism. Clergymen of Greater Poland were also active in secular absenteeism associations. They became involved in the workings of the Association for the Promotion of Absenteeism that was set up by Zygmunt Celichowski in Kórnik in 1887, and especially in the Jutrzenka Absenteeism Association

Revalidation of Ceresa terminalis walker and its placement in Stictocephala Stål (Hemiptera, Membracidae Revalidação de Ceresa terminalis walker e sua alocação em Stictocephala Stål (Hemiptera, Membracidae

Directory of Open Access Journals (Sweden)

Gabriel S. de Andrade

2005-12-01

Full Text Available Ceresa terminalis Walker, 1851 is reinstated and transferred to Stictocephala Stål, 1869: Stictocephala terminalis (Walker, 1851 sp. rev., comb. nov.Ceresa terminalis Walker, 1851 é revalidada e transferida para Stictocephala Stål, 1869: Stictocephala terminalis (Walker, 1851 sp. rev., comb. nov.

ATR-Hanford site emergency alerting system - 400 Area (F1-F2) and 600 Area (S6-S10)

International Nuclear Information System (INIS)

Whattam, J.W.

1998-01-01

This document provides the results of the acceptance test procedure performed under document number: HNF-2501, Rev 0. This Acceptance Test Procedure has been prepared to demonstrate the Hanford Site Emergency Alerting System functions as required by Specification WHC-S0454, Rev. 1 and project criteria

Improved Analysis of GW150914 Using a Fully Spin-Precessing Waveform Model

NARCIS (Netherlands)

Abbott, B. P.; Abbott, R.; Abbott, T. D.; Abernathy, M. R.; Acernese, F.; Ackley, K.; Adams, C.; Phythian-Adams, A.T.; Addesso, P.; Adhikari, R. X.; Adya, V. B.; Affeldt, C.; Agathos, M.; Agatsuma, K.; Aggarwal, N.T.; Aguiar, O. D.; Aiello, L.; Ain, A.; Ajith, P.; Allen, B.; Allocca, A.; Altin, P. A.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Arceneaux, C. C.; Areeda, J. S.; Arnaud, N.; Arun, K. G.; Ascenzi, S.; Ashton, G.; Ast, M.; Aston, S. M.; Astone, P.; Aufmuth, P.; Aulbert, C.; Babak, S.; Bacon, P.; Bader, M. K. M.; Baker, P. T.; Baldaccini, F.; Ballardin, G.; Ballmer, S. W.; Barayoga, J. C.; Barclay, S. E.; Barish, B. C.; Barker, R.D.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J. C.; Baune, C.; Bavigadda, V.; Bazzan, M.; Bejger, M.; Bell, A. S.; Berger, B. K.; Bergmann, G.; Berry, C. P. L.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Birch, M.J.; Birney, R.; Birnholtz, O.; Biscans, S.; Bisht, A.; Bitossi, M.; Biwer, C.; Bizouard, M. A.; Blackburn, J. K.; Blair, C. D.; Blair, D. G.; Blair, R. M.; Bloemen, A.L.S.; Bock, O.; Boer, M.; Bogaert, J.G.; Bogan, C.; Bohe, A.; Bond, T.C; Bondu, F.; Bonnand, R.; Boom, B. A.; Bork, R.; Boschi, V.; Bose, S.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brau, J. E.; Briant, T.; Brillet, A.; Brinkmann, M.; Brisson, V.; Brockill, P.; Broida, J. E.; Brooks, A. F.; Brown, A.D.; Brown, D.; Brown, N. M.; Brunett, S.; Buchanan, C. C.; Buikema, A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cabero, M.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Bustillo, J. Calderon; Callister, T. A.; Calloni, E.; Camp, J. B.; Cannon, K. C.; Cao, J.; Capano, C. D.; Capocasa, E.; Carbognani, F.; Caride, S.; Diaz, J. Casanueva; Casentini, J.; Caudill, S.; Cavaglia, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C. B.; Baiardi, L. Cerboni; Cerretani, G.; Cesarini, E.; Chamberlin, S. J.; Chan, M.; Chao, D. S.; Charlton, P.; Chassande-Mottin, E.; Cheeseboro, B. D.; Chen, H. Y.; Chen, Y; Cheng, C.; Chincarini, A.; Chiummo, A.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Qian; Chua, S. E.; Chung, E.S.; Ciani, G.; Clara, F.; Clark, J. A.; Cleva, F.; Coccia, E.; Cohadon, P. -F.; Colla, A.; Collette, C. G.; Cominsky, L.; Constancio, M., Jr.; Conte, A.; Conti, L.; Cook, D.; Corbitt, T. R.; Cornish, N.; Corsi, A.; Cortese, S.; Costa, A.C.; Coughlin, M. W.; Coughlin, S. B.; Coulon, J. -P.; Countryman, S. T.; Couvares, P.; Cowan, E. E.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Craig, K.; Creighton, J. D. E.; Cripe, J.; Crowder, S. G.; Cumming, A.; Cunningham, A.L.; Cuoco, E.; Dal Canton, T.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Darman, N. S.; Dasgupta, A.; Da Silva Costa, C. F.; Dattilo, V.; Dave, I.; Davier, M.; Davies, G. S.; Daw, E. J.; Day, R.; De, S.; Debra, D.; Debreczeni, G.; Degallaix, J.; De laurentis, M.; Deleglise, S.; Del Pozzo, W.; Denker, T.; Dent, T.; Dergachev, V.A.; Rosa, R.; DeRosa, R. T.; DeSalvo, R.; Devine, R. C.; Dhurandhar, S.; Diaz, M. C.; Di Fiore, L.; Giovanni, M.G.; Di Girolamo, T.; Di Lieto, A.; Di Pace, S.; Di Palma, I.; Di Virgilio, A.; Dolique, V.; Donovan, F.; Dooley, K. L.; Doravari, S.; Douglas, R.; Downes, T. P.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Ducrot, M.; Dwyer, S. E.; Edo, T. B.; Edwards, M. C.; Effler, A.; Eggenstein, H. -B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Engels, W.; Essick, R. C.; Etienne, Z.; Etzel, T.; Evans, T. M.; Evans, T. M.; Everett, R.; Factourovich, M.; Fafone, V.; Fair, H.; Fairhurst, S.; Fan, X.M.; Fang, Q.; Farinon, S.; Farr, B.; Farr, W. M.; Fauchon-Jones, E. J.; Favata, M.; Fays, M.; Fehrmann, H.; Fejer, M. M.; Fenyvesi, E.; Ferrante, I.; Ferreira, E. C.; Ferrini, F.; Fidecaro, F.; Fiori, I.; Fiorucci, D.; Fisher, R. P.; Flaminio, R.; Fletcher, M; Fournier, J. -D.; Frasca, S.; Frasconi, F.; Frei, Z.; Freise, A.; Frey, R.; Frey, V.; Fritschel, P.; Frolov, V. V.; Fulda, P.; Fyffe, M.; Gabbard, H. A. G.; Gaebel, S. M.; Gair, J. R.; Gammaitoni, L.; Gaonkar, S. G.; Garufi, F.; Gaur, G.; Gehrels, N.; Gemme, G.; Geng, P.; Genin, E.; Gennai, A.; George, J.; Gergely, L.; Germain, V.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, S.; Giaime, J. A.; Giardina, K. D.; Giazotto, A.; Gill, K.P.; Glaefke, A.; Goetz, E.; Goetz, R.; Gondan, L.; Gonzalez, R.G.; Castro, J. M. Gonzalez; Gopakumar, A.; Gordon, N. A.; Gorodetsky, M. L.; Gossan, S. E.; Lee-Gosselin, M.; Gouaty, R.; Grado, A.; Graef, C.; Graff, P. B.; Granata, M.; Grant, A.; Gras, S.; Gray, C.M.; Greco, G.; Green, A. C.; Groot, P.; Grote, H.; Grunewald, S.; Guidi, G. M.; Guo, X.; Gupta, A.; Gupta, M. K.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hacker, J. J.; Buffoni-Hall, R.; Hall, E. D.; Hammond, G.L.; Haney, M.; Hanke, M. M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hanson, P.J.; Hardwick, T.; Harms, J.; Harry, G. M.; Harry, I. W.; Hart, M. J.; Hartman, M. T.; Haster, C. -J.; Haughian, K.; Healy, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Hennig, J.; Henry, J.A.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hoak, D.; Hofman, D.; Holt, K.; Holz, D. E.; Hopkins, P.; Hough, J.; Houston, E. A.; Howell, E. J.; Hu, Y. M.; Huang, S.; Huerta, E. A.; Huet, D.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Indik, N.; Ingram, D. R.; Inta, R.; Isa, H. N.; Isac, J. -M.; Isi, M.; Isogai, T.; Iyer, B. R.; Izumi, K.; Jacqmin, T.; Jang, D.H.; Jani, K.; Jaranowski, P.; Jawahar, S.; Jian, L.; Jimenez-Forteza, F.; Johnson, W.; Johnson-McDaniel, N. K.; Jones, I.D.; Jones, R.; Jonker, R. J. G.; Ju, L.; Haris, K.; Kalaghatgi, C. V.; Kalogera, V.; Kandhasamy, S.; Kang, G.H.; Kanner, J. B.; Kapadia, S. J.; Karki, S.; Karvinen, K. S.; Kasprzack, M.; Katsavounidis, E.; Katzman, W.; Kaufer, S.; Kaur, T.; Kawabe, K.; Kefelian, F.; Kehl, M. S.; Keitel, D.; Kelley, D. B.; Kells, W.; Kennedy, R.E.; Key, J. S.; Khalili, F. Y.; Khan, I.; Khan., S.; Khan, Z.; Khazanov, E. A.; Kijbunchoo, N.; Kim, Chi-Woong; Kim, Chunglee; Kim, J.; Kim, K.; Kim, Namjun; Kim, W.; Kim, Y.M.; Kimbrell, S. J.; King, E. J.; King, P. J.; Kissel, J. S.; Klein, B.; Kleybolte, L.; Klimenko, S.; Koehlenbeck, S. M.; Koley, S.; Kondrashov, V.; Kontos, A.; Korobko, M.; Korth, W. Z.; Kowalska, I.; Kozak, D. B.; Kringel, V.; Krolak, A.; Krueger, C.; Kuehn, G.; Kumar, P.; Kumar, R.; Kuo, L.; Kutynia, A.; Lackey, B. D.; Landry, M.; Lange, J.; Lantz, B.; Lasky, P. D.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lebigot, E. O.; Lee, C.H.; Lee, K.H.; Lee, M.H.; Lee, K.; Lenon, A.; Leonardi, M.; Leong, J. R.; Leroy, N.; Letendre, N.; Levin, Y.; Lewis, J. B.; Li, T. G. F.; Libson, A.; Littenberg, T. B.; Lockerbie, N. A.; Lombardi, A. L.; London, L. T.; Lord, J. E.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J. D.; Lousto, C. O.; Lovelace, G.; Lueck, H.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magana-Sandoval, F.; Zertuche, L. Magana; Magee, R. M.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Mandic, V.; Mangano, V.; Mansell, G. L.; Manske, M.; Mantovani, M.; Marchesoni, F.; Marion, F.; Marka, S.; Markosyan, A. S.; Maros, E.; Martelli, F.; Martellini, L.; Martin, I. W.; Martynov, D. V.; Marx, J. N.; Mason, K.; Masserot, A.; Massinger, T. J.; Masso-Reid, M.; Mastrogiovanni, S.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McGuire, S. C.; McIntyre, G.; McIver, J.; McManus, D. J.; McRae, T.; McWilliams, S. T.; Meacher, D.; Meadors, G. D.; Meidam, J.; Melatos, A.; Mendell, G.; Mercer, R. A.; Merilh, E. L.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Metzdorff, R.; Meyers, P. M.; Mezzani, F.; Miao, H.; Michel, C.; Middleton, H.; Mikhailov, E. E.; Milano, L.; Miller, A. L.; Miller, A. L.; Miller, B.; Miller, J.; Millhouse, M.; Minenkov, Y.; Ming, J.; Mirshekari, S.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moggi, A.; Mohan, M.; Mohapatra, S. R. P.; Montani, M.; Moore, B.C.; Moore, J.C.; Moraru, D.; Gutierrez Moreno, M.; Morriss, S. R.; Mossavi, K.; Mours, B.; Mow-Lowry, C. M.; Mueller, G.; Muir, A. W.; Mukherjee, Arunava; Mukherjee, S.D.; Mukherjee, S.; Mukund, N.; Mullavey, A.; Munch, J.; Murphy, D. J.; Murray, P.G.; Mytidis, A.; Nardecchia, I.; Naticchioni, L.; Nayak, R. K.; Nedkova, K.; Nelemans, G.; Nelson, T. J. N.; Gutierrez-Neri, M.; Neunzert, A.; Newton-Howes, G.; Nguyen, T. T.; Nielsen, A. B.; Nissanke, S.; Nitz, A.; Nocera, F.; Nolting, D.; Normandin, M. E. N.; Nuttall, L. K.; Oberling, J.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J.; Oh, S. H.; Ohme, F.; Oliver, M. B.; Oppermann, P.; Oram, Richard J.; O'Reilly, B.; O'Shaughnessy, R.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pai, A.; Pai, S. A.; Palamos, J. R.; Palashov, O.; Palomba, C.; Pal-Singh, A.; Pan, H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Paoletti, F.; Paoli, A.; Papa, M. A.; Paris, H. R.; Parker, W.S; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patricelli, B.; Patrick, Z.; Pearlstone, B. L.; Pedraza, M.; Pedurand, R.; Pekowsky, L.; Pele, A.; Penn, S.; Perreca, A.; Perri, L. M.; Pfeiffer, H. P.; Phelps, M.; Piccinni, O. J.; Pichot, M.; Piergiovanni, F.; Pierro, V.; Pillant, G.; Pinard, L.; Pinto, I. M.; Pitkin, M.; Poe, M.; Poggiani, R.; Popolizio, P.; Post, A.; Powell, J.; Prasad, J.; Predoi, V.; Prestegard, T.; Price, L. R.; Prijatelj, M.; Principe, M.; Privitera, S.; Prix, R.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Puerrer, M.; Qi, H.; Qin, J.; Qiu, S.; Quetschke, V.; Quintero, E. A.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajan, C.; Rakhmanov, M.; Rapagnani, P.; Raymond, V.; Razzano, M.; Re, V.; Read, J.; Reed, C. M.; Regimbau, T.; Rei, L.; Reid, S.; Reitze, D. H.; Rew, H.; Reyes, S. D.; Ricci, F.; Riles, K.; Rizzo, D.M.; Robertson, N. A.; Robie, R.; Robinet, F.; Rocchi, A.; Rolland, L.; Rollins, J. G.; Roma, V. J.; Romano, R.; Romanov, G.; Romie, J. H.; Rosinska, D.; Rowan, S.; Ruediger, A.; Ruggi, P.; Ryan, K.A.; Sachdev, P.S.; Sadecki, T.; Sadeghian, L.; Sakellariadou, M.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sammut, L.; Sanchez, E. J.; Sandberg, V.; Sandeen, B.; Sanders, J. R.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Sauter, O. E. S.; Savage, R. L.; Sawadsky, A.; Schale, P.; Schilling, R.; Schmidt, J; Schmidt, P.; Schnabel, R.B.; Schofield, R. M. S.; Schoebeck, A.; Schreiber, K.E.C.; Schuette, D.; Schutz, B. F.; Scott, J.; Scott, M.S.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Setyawati, Y.; Shaddock, D. A.; Shaffer, T. J.; Shahriar, M. S.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Sheperd, A.; Shoemaker, D. H.; Shoemaker, D. M.; Siellez, K.; Siemens, X.; Sieniawska, M.; Sigg, D.; Silva, António Dias da; Singer, A; Singer, L. P.; Singh, A.; Singh, R.; Singhal, A.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, R. J. E.; Smith, N.D.; Smith, R. J. E.; Son, E. J.; Sorazu, B.; Sorrentino, F.; Souradeep, T.; Srivastava, A. K.; Staley, A.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stephens, B. C.; Stevenson-Moore, P.; Stone, J.R.; Strain, K. A.; Straniero, N.; Stratta, G.; Strauss, N. A.; Strigin, S. E.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sun, L.; Sunil, S.; Sutton, P. J.; Swinkels, B. L.; Szczepanczyk, M. J.; Tacca, M.D.; Talukder, D.; Tanner, D. B.; Tapai, M.; Tarabrin, S. P.; Taracchini, A.; Taylor, W.R.; Theeg, T.; Thirugnanasambandam, M. P.; Thomas, E. G.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Tiwari, S.; Tiwari, V.; Tokmakov, K. V.; Toland, K.; Tomlinson, C.; Tonelli, M.; Tornasi, Z.; Torres, C. V.; Torrie, C. I.; Toyra, D.; Travasso, F.; Traylor, G.; Trifiro, D.; Tringali, M. C.; Trozzo, L.; Tse, M.; Turconi, M.; Tuyenbayev, D.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; Vallisneri, M.; van Bakel, N.; van Beuzekom, M.G.; van den Brand, J. F. J.; Van Den Broeck, C.F.F.; Vander-Hyde, D. C.; van der Schaaf, L.; van der Sluys, M. V.; van Heijningen, J. V.; Vano-Vinuales, A.; van Veggel, A. A.; Vardaro, M.; Vass, S.; Vasuth, M.; Vaulin, R.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P.J.; Venkateswara, K.; Verkindt, D.; Vetrano, F.; Vicere, A.; Vinciguerra, S.; Vine, D. J.; Vinet, J. -Y.; Vitale, S.; Vo, T.; Vocca, H.; Vorvick, C.; Voss, D. V.; Vousden, W. D.; Vyatchanin, S. P.; Wade, A. R.; Wade, L. E.; Wade, MT; Walker, M.; Wallace, L.; Walsh, S.; Wang, G.; Wang, H.; Wang, M.; Wang, X.; Wang, Y.; Ward, R. L.; Warner, J.; Was, M.; Weaver, B.; Wei, L. -W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Wen, L.M.; Wessels, P.; Westphal, T.; Wette, K.; Whelan, J. T.; Whiting, B. F.; Williams, D.R.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M. H.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Woehler, J.; Worden, J.; Wright, J.L.; Wu, D.S.; Wu, G.; Yablon, J.; Yam, W.; Yamamoto, H.; Yancey, C. C.; Yu, H.; Yvert, M.; Zadrozny, A.; Zangrando, L.; Zanolin, M.; Zendri, J. -P.; Zevin, M.; Zhang, L.; Zhang, M.; Zhang, Y.; Zhao, C.; Zhou, M.; Zhou, Z.; Zhu, X. J.; Zucker, M. E.; Zuraw, S. E.; Zweizig, J.; Boyle, M.; Bruegmann, B.; Campanelli, M.; Chu, I.W.T.; Clark, M.; de Haas, R.; Hemberger, D.; Hinder, I.; Kidder, L. E.; Kinsey, M.; Laguna, P.; Ossokine, S.; Pan, Y.; Roever, C.; Scheel, M.; Szilagyi, B.; Teukolsky, S.; Zlochower, Y.

2016-01-01

This paper presents updated estimates of source parameters for GW150914, a binary black-hole coalescence event detected by the Laser Interferometer Gravitational-wave Observatory (LIGO) in 2015 [Abbott et al. Phys. Rev. Lett. 116, 061102 (2016).]. Abbott et al. [Phys. Rev. Lett. 116, 241102 (2016).

Accuracy of the microcanonical Lanczos method to compute real-frequency dynamical spectral functions of quantum models at finite temperatures

Science.gov (United States)

Okamoto, Satoshi; Alvarez, Gonzalo; Dagotto, Elbio; Tohyama, Takami

2018-04-01

We examine the accuracy of the microcanonical Lanczos method (MCLM) developed by Long et al. [Phys. Rev. B 68, 235106 (2003), 10.1103/PhysRevB.68.235106] to compute dynamical spectral functions of interacting quantum models at finite temperatures. The MCLM is based on the microcanonical ensemble, which becomes exact in the thermodynamic limit. To apply the microcanonical ensemble at a fixed temperature, one has to find energy eigenstates with the energy eigenvalue corresponding to the internal energy in the canonical ensemble. Here, we propose to use thermal pure quantum state methods by Sugiura and Shimizu [Phys. Rev. Lett. 111, 010401 (2013), 10.1103/PhysRevLett.111.010401] to obtain the internal energy. After obtaining the energy eigenstates using the Lanczos diagonalization method, dynamical quantities are computed via a continued fraction expansion, a standard procedure for Lanczos-based numerical methods. Using one-dimensional antiferromagnetic Heisenberg chains with S =1 /2 , we demonstrate that the proposed procedure is reasonably accurate, even for relatively small systems.

Identifying Growth Conditions for Nicotiana benthimiana Resulting in Predictable Gene Expression of Promoter-Gus Fusion

Science.gov (United States)

Sandoval, V.; Barton, K.; Longhurst, A.

2012-12-01

Revoluta (Rev) is a transcription factor that establishes leaf polarity inArabidopsis thaliana. Through previous work in Dr. Barton's Lab, it is known that Revoluta binds to the ZPR3 promoter, thus activating the ZPR3 gene product inArabidopsis thaliana. Using this knowledge, two separate DNA constructs were made, one carrying revgene and in the other, the ZPR3 promoter fussed with the GUS gene. When inoculated in Nicotiana benthimiana (tobacco), the pMDC32 plasmid produces the Rev protein. Rev binds to the ZPR3 promoter thereby activating the transcription of the GUS gene, which can only be expressed in the presence of Rev. When GUS protein comes in contact with X-Gluc it produce the blue stain seen (See Figure 1). In the past, variability has been seen of GUS expression on tobacco therefore we hypothesized that changing the growing conditions and leaf age might improve how well it's expressed.

Comment on "Fractional quantum mechanics" and "Fractional Schrödinger equation".

Science.gov (United States)

Wei, Yuchuan

2016-06-01

In this Comment we point out some shortcomings in two papers [N. Laskin, Phys. Rev. E 62, 3135 (2000)10.1103/PhysRevE.62.3135; N. Laskin, Phys. Rev. E 66, 056108 (2002)10.1103/PhysRevE.66.056108]. We prove that the fractional uncertainty relation does not hold generally. The probability continuity equation in fractional quantum mechanics has a missing source term, which leads to particle teleportation, i.e., a particle can teleport from a place to another. Since the relativistic kinetic energy can be viewed as an approximate realization of the fractional kinetic energy, the particle teleportation should be an observable relativistic effect in quantum mechanics. With the help of this concept, superconductivity could be viewed as the teleportation of electrons from one side of a superconductor to another and superfluidity could be viewed as the teleportation of helium atoms from one end of a capillary tube to the other. We also point out how to teleport a particle to an arbitrary destination.

Thermodynamic aspects of information transfer in complex dynamical systems

Science.gov (United States)

Cafaro, Carlo; Ali, Sean Alan; Giffin, Adom

2016-02-01

From the Horowitz-Esposito stochastic thermodynamical description of information flows in dynamical systems [J. M. Horowitz and M. Esposito, Phys. Rev. X 4, 031015 (2014), 10.1103/PhysRevX.4.031015], it is known that while the second law of thermodynamics is satisfied by a joint system, the entropic balance for the subsystems is adjusted by a term related to the mutual information exchange rate between the two subsystems. In this article, we present a quantitative discussion of the conceptual link between the Horowitz-Esposito analysis and the Liang-Kleeman work on information transfer between dynamical system components [X. S. Liang and R. Kleeman, Phys. Rev. Lett. 95, 244101 (2005), 10.1103/PhysRevLett.95.244101]. In particular, the entropic balance arguments employed in the two approaches are compared. Notwithstanding all differences between the two formalisms, our work strengthens the Liang-Kleeman heuristic balance reasoning by showing its formal analogy with the recent Horowitz-Esposito thermodynamic balance arguments.

Machinability baja AISI 1040 pada proses bubut dengan variasi cutting speed dan feed rate

Directory of Open Access Journals (Sweden)

AAIA Sri Komaladewi

2012-11-01

Full Text Available In order to obtain desired results of machining process (turning, parameter of process and material characteristic to be machined should be well known. This is due to different machining conditions and material yield different material machinability as well. It is needed to investigate of material machinability (AISI 1040 such as force, power and shear angle under different cutting speed (80, 160 and 240 m/min and feed rate (0.1, 0.2, and 0.3 mm/rev. The results of investigation show that; at the same cutting speed the higher feed rate the higher cutting force needed; the higher cutting speed and feed rate, the higher power needed; at feed rate 0.1 mm./rev and 0.3 mm/rev, the higher cutting speed the shear angles has a trend to incline; at feed rate 0.2 mm/rev, cutting speed from 80 to 160 m/min yield increasing of shear angle, however, from 160 to 240 m/min shear angle declines.

Comment on "Particle path through a nested Mach-Zehnder interferometer"

Science.gov (United States)

Salih, Hatim

2018-02-01

In a recent paper [Phys. Rev. A 94, 032115 (2016), 10.1103/PhysRevA.94.032115], Griffiths questioned—based on an interesting consistent-histories (CH) argument—the counterfactuality, for one of the bit choices, of the protocol of Salih et al. for communicating without sending physical particles [Phys. Rev. Lett. 110, 170502 (2013), 10.1103/PhysRevLett.110.170502]. Here, we first show that for the Mach-Zehnder version used to explain our protocol, contrary to Griffiths's claim, no family of consistent histories exists where any history has the photon traveling through the communication channel, thus rendering the question of whether the photon was in the communication channel meaningless from a CH viewpoint. We then show that for the actual Michelson-type protocol, there is a consistent-histories family for each cycle that includes histories where the photon travels through the communication channel. We show that the probability of finding the photon in the communication channel at any time is zero—proving complete counterfactuality.

Non-unique monopole oscillations of harmonically confined Yukawa systems

Science.gov (United States)

Ducatman, Samuel; Henning, Christian; Kaehlert, Hanno; Bonitz, Michael

2008-11-01

Recently it was shown that the Breathing Mode (BM), the mode of uniform radial expansion and contraction, which is well known from harmonically confined Coulomb systems [1], does not exist in general for other systems [2]. As a consequence the monopole oscillation (MO), the radial collective excitation, is not unique, but there are several MO with different frequencies. Within this work we show simulation results of those monopole oscillations of 2-dimensional harmonically confined Yukawa systems, which are known from, e.g., dusty plasma crystals [3,4]. We present the corresponding spectrum of the particle motion, including analysis of the frequencies found, and compare with theoretical investigations.[1] D.H.E. Dubin and J.P. Schiffer, Phys. Rev. E 53, 5249 (1996)[2] C. Henning at al., accepted for publication in Phys. Rev. Lett. (2008)[3] A. Melzer et al., Phys. Rev. Lett. 87, 115002 (2001)[4] M. Bonitz et al., Phys. Rev. Lett. 96, 075001 (2006)

STANDING CONCERTATION COMMMITTEE

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HR Department

2008-01-01

ORDINARY MEETING ON 27 FEBRUARY 2008 The main items discussed at the meetings of the Standing Concertation Committee on 27 February 2008 included: Short-term Saved Leave Scheme The committee noted that, by the end of February 2008, some 600 staff had subscribed to the short-term saved leave scheme: approx 58% had subscribed 1 slice, 14% two slices, 5% three slices and 23% four slices. Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme The committee agreed to recommend Administrative Circular No. 4 (Rev. 4) - Unemployment Insurance Scheme to the Director-General for approval. Administrative Circular No. 30 (Rev. 2) - Financial benefits upon taking up appointment and termination of contract The committee agreed to recommend Administrative Circular No. 30 (Rev. 2) - Financial Benefits upon taking up appointment and termination of contract to the Director-General for approval. Progressive Retirement Programme The Progressive Retirement Programme (PRP) was extended for a further year to 3...

Spin entanglement in elastic electron scattering from lithium atoms

Science.gov (United States)

Bartschat, K.; Santos, S. Fonseca dos

2017-04-01

In two recent papers [Blum and Lohmann, Phys. Rev. Lett. 116, 033201 (2016), 10.1103/PhysRevLett.116.033201; Lohmann et al., Phys. Rev. A 94, 032331 (2016), 10.1103/PhysRevA.94.032331], the possibility of continuously varying the degree of entanglement between an elastically scattered electron and the valence electron of an alkali-metal target was discussed. To estimate how well such a scheme may work in practice, we present results for elastic electron scattering from lithium in the energy regime of 1 -5 eV and the full range of scattering angles 0∘-180∘ . The most promising regime for Bell correlations in this particular collision system are energies between about 1.5 and 3.0 eV, in an angular range around 110∘±10∘ . In addition to the relative exchange asymmetry parameter, we present the differential cross section that is important when estimating the count rate and hence the feasibility of experiments using this system.

Effect of different cycling frequencies during incremental exercise on the venous plasma potassium concentration in humans.

Science.gov (United States)

Zoladz, J A; Duda, K; Majerczak, J; Thor, P

2002-01-01

The effect of different muscle shortening velocity was studied during cycling at a pedalling rate of 60 and 120 rev.min(-1) on the [K+]v in humans. Twenty-one healthy young men aged 22.5+/-2.2 years, body mass 72.7+/-6.4 kg, VO2 max 3.720+/-0.426 l. min(-1), performed an incremental exercise test until exhaustion. The power output increased by 30 W every 3 min, using an electrically controlled ergometer Ergoline 800 S (see Zoladz et al. J. Physiol. 488: 211-217, 1995). The test was performed twice: once at a cycling frequency of 60 rev.min(-1) (test A) and a few days later at a frequency of 120 rev. min(-1) (test B). At rest and at the end of each step (i.e. the last 15 s) antecubital venous blood samples for [K+]p were taken. Gas exchange variables were measured continuously (breath-by-breath) using Oxycon Champion Jaeger. The pre-exercise [K+]v in both tests was not significantly different amounting to 4.24+/-0.36 mmol.l(-1) in test A, and 4.37+/-0.45 mmol.l(-1) in test B. However, the [K+]p during cycling at 120 rev. min(-1) was significantly higher (p<0.001, ANOVA for repeated measurements) at each power output when compared to cycling at 60 rev.min(-1). The maximal power output reached 293+/-31 W in test A which was significantly higher (p<0.001) than in test B, which amounted to 223+/-40 W. The VO2max values in both tests reached 3.720+/-0.426 l. min(-1) vs 3.777+/-0.514 l. min(-1). These values were not significantly different. When the [K+]v was measured during incremental cycling exercise, a linear increase in [K+]v was observed in both tests. However, a significant (p<0.05) upward shift in the [K+]v and a % VO2max relationship was detected during cycling at 120 rev.min(-1). The [K+]v measured at the VO2max level in tests A and B amounted to 6.00+/-0.47 mmol.l-1 vs 6.04+/-0.41 mmol.l-1, respectively. This difference was not significant. It may thus be concluded that: a) generation of the same external mechanical power output during cycling at a pedalling

The Quebec Liberation Front (FLQ) as an Insurgency

Science.gov (United States)

2010-04-08

Histoire d’un mouvement clandestin, rev. ed. (Outremont, QC: Lanctôt Éditeur, 1998), 11. 4 targeted union workers and students. They also represented...Washington, DC: Government Printing Office, 2006. Fournier, Louis. FLQ: Histoire d’un mouvement clandestin. Rev. ed. Outremont, QC: Lanctôt Éditeur

Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.

Science.gov (United States)

Nin, Veronica; Chini, Claudia C S; Escande, Carlos; Capellini, Verena; Chini, Eduardo N

2014-02-28

Liver gluconeogenesis is essential to provide energy to glycolytic tissues during fasting periods. However, aberrant up-regulation of this metabolic pathway contributes to the progression of glucose intolerance in individuals with diabetes. Phosphoenolpyruvate carboxykinase (PEPCK) expression plays a critical role in the modulation of gluconeogenesis. Several pathways contribute to the regulation of PEPCK, including the nuclear receptor Rev-erbα and the histone deacetylase SIRT1. Deleted in breast cancer 1 (DBC1) is a nuclear protein that binds to and regulates both Rev-erbα and SIRT1 and, therefore, is a candidate to participate in the regulation of PEPCK. In this work, we provide evidence that DBC1 regulates glucose metabolism and the expression of PEPCK. We show that DBC1 levels decrease early in the fasting state. Also, DBC1 KO mice display higher gluconeogenesis in a normal and a high-fat diet. DBC1 absence leads to an increase in PEPCK mRNA and protein expression. Conversely, overexpression of DBC1 results in a decrease in PEPCK mRNA and protein levels. DBC1 regulates the levels of Rev-erbα, and manipulation of Rev-erbα activity or levels prevents the effect of DBC1 on PEPCK. In addition, Rev-erbα levels decrease in the first hours of fasting. Finally, knockdown of the deacetylase SIRT1 eliminates the effect of DBC1 knockdown on Rev-erbα levels and PEPCK expression, suggesting that the mechanism of PEPCK regulation is, at least in part, dependent on the activity of this enzyme. Our results point to DBC1 as a novel regulator of gluconeogenesis.

Publication of administrative circular

CERN Multimedia

HR Department

2009-01-01

ADMINISTRATIVE CIRCULAR NO. 23 (REV. 2) – SPECIAL WORKING HOURS Administrative Circular No. 23 (Rev. 2) entitled "Special working hours", approved following discussion in the Standing Concertation Committee on 9 December 2008, will be available on the intranet site of the Human Resources Department as from 19 December 2008: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 23 (Rev. 1) entitled "Stand-by duty" of April 1988. A "Frequently Asked Questions" information document on special working hours will also be available on this site. Paper copies of this circular will shortly be available in Departmental Secretariats. Human Resources Department Tel. 78003

PUBLICATION OF ADMINISTRATIVE CIRCULAR

CERN Multimedia

HR Department

2008-01-01

ADMINISTRATIVE CIRCULAR NO. 23 (REV. 2) – SPECIAL WORKING HOURS Administrative Circular No. 23 (Rev. 2) entitled "Special working hours", approved following discussion in the Standing Concertation Committee meeting of 9 December 2008, will be available on the intranet site of the Human Resources Department as from 19 December 2008: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 23 (Rev. 1) entitled "Stand-by duty" of April 1988. A "Frequently Asked Questions" information document on special working hours will also be available on this site. Paper copies of this circular will shortly be available in departmental secretariats. Human Resources Department Tel. 78003

Dicty_cDB: Contig-U16175-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available se ... 76 4e-09 1 ( FE846729 ) CAFI888.fwd CAFI Pichia stipitis aerobic dextrose... 76 4e-09 1 ( FE846728 ) ...CAFI888.rev CAFI Pichia stipitis aerobic dextrose... 76 4e-09 1 ( FE846485 ) CAFI759.fwd CAFI Pichia stipitis aerobic dextrose...... 76 4e-09 1 ( FE846484 ) CAFI759.rev CAFI Pichia stipitis aerobic dextrose...... 76 4e-09 1 ( FE845925 ) CAFI458.fwd CAFI Pichia stipitis aerobic dextrose... 76 4e-09 1 ( ...FE845924 ) CAFI458.rev CAFI Pichia stipitis aerobic dextrose... 76 4e-09 1 ( FE845522 ) CAFI1010.fwd CAFI Pi

Dicty_cDB: Contig-U15113-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available rev CAFH Pichia stipitis aerobic dextrose... 86 7e-25 4 ( FE856969 ) CAFU914.fwd CAFU Pichia stipitis oxygen...hia stipitis aerobic xylose ... 86 8e-25 4 ( FE846404 ) CAFI716.fwd CAFI Pichia stipitis aerobic dextrose...... 86 8e-25 4 ( FE844479 ) CAFH437.fwd CAFH Pichia stipitis aerobic dextrose... 86 8e-25 4 ( EC762481 ) PSE000...trose... 86 6e-25 4 ( FE851519 ) CAFP1757.fwd CAFP Pichi... FE856968 ) CAFU914.rev CAFU Pichia stipitis oxygen limited d... 86 6e-25 4 ( FE846403 ) CAFI716.rev CAFI Pichia stipitis aerobic dex

Quantitative study of quasi-one-dimensional Bose gas experiments via the stochastic Gross-Pitaevskii equation

International Nuclear Information System (INIS)

Cockburn, S. P.; Gallucci, D.; Proukakis, N. P.

2011-01-01

The stochastic Gross-Pitaevskii equation is shown to be an excellent model for quasi-one-dimensional Bose gas experiments, accurately reproducing the in situ density profiles recently obtained in the experiments of Trebbia et al.[Phys. Rev. Lett. 97, 250403 (2006)] and van Amerongen et al.[Phys. Rev. Lett. 100, 090402 (2008)] and the density fluctuation data reported by Armijo et al.[Phys. Rev. Lett. 105, 230402 (2010)]. To facilitate such agreement, we propose and implement a quasi-one-dimensional extension to the one-dimensional stochastic Gross-Pitaevskii equation for the low-energy, axial modes, while atoms in excited transverse modes are treated as independent ideal Bose gases.

Effect of pedaling rates and myosin heavy chain composition in the vastus lateralis muscle on the power generating capability during incremental cycling in humans.

Science.gov (United States)

Majerczak, J; Szkutnik, Z; Duda, K; Komorowska, M; Kolodziejski, L; Karasinski, J; Zoladz, J A

2008-01-01

In this study, we have determined power output reached at maximal oxygen uptake during incremental cycling exercise (P(I, max)) performed at low and at high pedaling rates in nineteen untrained men with various myosin heavy chain composition (MyHC) in the vastus lateralis muscle. On separate days, subjects performed two incremental exercise tests until exhaustion at 60 rev min(-1) and at 120 rev min(-1). In the studied group of subjects P(I, max) reached during cycling at 60 rev min(-1) was significantly higher (p=0.0001) than that at 120 rev min(-1) (287+/-29 vs. 215+/-42 W, respectively for 60 and 120 rev min(-1)). For further comparisons, two groups of subjects (n=6, each) were selected according to MyHC composition in the vastus lateralis muscle: group H with higher MyHC II content (56.8+/-2.79 %) and group L with lower MyHC II content in this muscle (28.6+/-5.8 %). P(I, max) reached during cycling performed at 60 rev min(-1) in group H was significantly lower than in group L (p=0.03). However, during cycling at 120 rev min(-1), there was no significant difference in P(I, max) reached by both groups of subjects (p=0.38). Moreover, oxygen uptake (VO(2)), blood hydrogen ion [H(+)], plasma lactate [La(-)] and ammonia [NH(3)] concentrations determined at the four highest power outputs completed during the incremental cycling performed at 60 as well as 120 rev min(-1), in the group H were significantly higher than in group L. We have concluded that during an incremental exercise performed at low pedaling rates the subjects with lower content of MyHC II in the vastus lateralis muscle possess greater power generating capabilities than the subjects with higher content of MyHC II. Surprisingly, at high pedaling rate, power generating capabilities in the subjects with higher MyHC II content in the vastus lateralis muscle did not differ from those found in the subjects with lower content of MyHC II in this muscle, despite higher blood [H(+)], [La(-)] and [NH(3

76 FR 34763 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

Science.gov (United States)

2011-06-14

... approved [Nuclear Energy Institute (NEI)] 04-10, Rev. 1 in accordance with the TS SFCP. NEI 04-10, Rev. 1... environmental impact statement or environmental assessment need be prepared for these amendments. If the...'s property, financial, or other interest in the proceeding; and (4) the possible effect of any...

AGOR 28: SIO Shipyard Representative Bi-Weekly Progress Report

Science.gov (United States)

2014-03-13

MAINTENANCE PROCEDURES ( 505-02.2 FLUSHING PROCEDURE FOR BALLAST SYSTEMS) (DARC REV) Nov-00 AGOR27 A051 STD Report - VENDOR RECOMMENDED SPARES (VRS...Report - COMMERCIAL TECHNICAL MANUALS AND SUPPLEMENTAL DATA ( #224 DI-055 (TM) for 433 AGOR Tailored LAN & CCTV ) (DARC REV) 448/0 AGOR27 A055 TM

Characterization of high-dimensional entangled systems via mutually unbiased measurements

CSIR Research Space (South Africa)

Giovannini, D

2013-04-01

Full Text Available . Cerf, J. Phys. A 35, 10 065 (2002). [24] N. J. Cerf, M. Bourennane, A. Karlsson, and N. Gisin, Phys. Rev. Lett. 88, 127902 (2002). [25] H. Bechmann-Pasquinucci and W. Tittel, Phys. Rev. A 61, 062308 (2000). [26] S. P. Walborn, D. S. Lemelle, M. P...

Generation of Bright Phase-matched Circularly-polarized Extreme Ultraviolet High Harmonics

Science.gov (United States)

2014-12-08

1995). 42. Eichmann , H. et al. Polarization-dependent high-order two-color mixing. Phys. Rev. A 51, R3414–R3417 (1995). 43. Fleischer, A., Kfir, O...calculations of polarization-dependent two- color high-harmonic generation. Phys. Rev. A 52, 2262–2278 (1995). 10. Eichmann , H. et al. polarization