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  1. Administrative Circulars Rev.

    CERN Multimedia

    2003-01-01

    Administrative Circular N° 19 (Rev. 3) - April 2003 Subsistence indemnity - Other expenses necessarily incurred in the course of duty travelAdministrative Circular N° 25 (Rev. 2) - April 2003 Shift work - Special provisions for the Fire and Rescue Service - These circulars have been revised. Human Resources Division Tel. 74128Copies of these circulars are available in the Divisional Secretariats. In addition, administrative and operational circulars, as well as the lists of those in force, are available for consultation on the Web at: http://humanresources.web.cern.ch/humanresources/internal/admin_services/admincirc/listadmincirc.asp

  2. Optimized Chemical Probes for REV-ERBα

    OpenAIRE

    Trump, Ryan P.; Bresciani, Stefano; Cooper, Anthony W. J.; Tellam, James P.; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A.; Kashatus, Jennifer A.; Dawson, Helen C.; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N.; Willson, Timothy M.; Tomkinson, Nicholas C. O.

    2013-01-01

    REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either IV o...

  3. Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496

    Energy Technology Data Exchange (ETDEWEB)

    Humphries, Larry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.

  4. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function

    DEFF Research Database (Denmark)

    Bugge, Anne Skovsø; Feng, Dan; Everett, Logan J

    2012-01-01

    of binding sites across the genome, enriched near metabolic genes. Depletion of both Rev-erbs in liver synergistically derepresses several metabolic genes as well as genes that control the positive limb of the molecular clock. Moreover, deficiency of both Rev-erbs causes marked hepatic steatosis, in contrast......-autonomous clock as well as hepatic lipid metabolism. Mouse embryonic fibroblasts were rendered arrhythmic by depletion of both Rev-erbs. In mouse livers, Rev-erbβ mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbα, and both Rev-erbs are recruited to a remarkably similar set...

  5. Revised Safety Instruction 41 (IS41 REV.)

    CERN Multimedia

    SC Secretariat

    2005-01-01

    Please note that the Revised Safety Instruction No. 41 (IS41 REV.), entitled 'The use of plastic and other non-metallic materials at CERN with respect to fire safety and radiation resistance' is available on the web at the following url: https://edms.cern.ch/document/335806/LAST_RELEASED Paper copies can also be obtained from the SC Unit Secretariat, e-mail: sc.secretariat@cern.ch SC Secretariat

  6. Introducing RevPASH: The Free Webtool Application

    Directory of Open Access Journals (Sweden)

    Peter Szende

    2014-10-01

    Full Text Available RevPASH (Revenue Per Available Seat Hour is an important measure that helps restaurant operators understand how efficiently each seat in a restaurant generates revenue. The RevPASH app is an easy-to-use web-tool that provides an operator with a quick way to input a few relevant numbers and calculate RevPASH.The application has the ability to compare RevPASH over different times, days, weeks, and months.

  7. Rev 12 as a theology of history

    OpenAIRE

    Joanna Nowińska

    2009-01-01

    The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger), places (the temple, a desert), persons (the Child-Ruler, Michael) with the Old T...

  8. Rev 12 as a theology of history

    Directory of Open Access Journals (Sweden)

    Joanna Nowińska

    2009-12-01

    Full Text Available The Biblical writers notice history as the space of God’s rule. He is the director, who comes into contact with human being through signs – events and words, and also He is the history’s perpetuum mobile. Rev 12 specifically reflect nowadays and the previous in the context of the whole world’s vision and mix the reference to facts (lack of the temple, ark, faithful people, horrible experiences, the death danger, places (the temple, a desert, persons (the Child-Ruler, Michael with the Old Testament figurative exposing, a typical one for such a book (the Woman with Child, the heaven, the dragon, enriched with a lot of symbols (a crown, a horn, the moon under feet. God’s interference into World history is presented through lightning, voices, thunder, an earthquake and great hail, that stress His power and supremacy. The biblical writer refers to events, which make place whole the time in the natural- and supernatural space, like: the war between God and evil, persecutions, hiding, God’s care of men.  The specific literary structure of Rev 12, contrary to the other parts of that book, seem to help to put an accent for the fundamental truths for transcendental theology of history of which the most important is the eternal rule of God and only accidental, finished in the time perspective of Satan’s position.

  9. Suppression of atherosclerosis by synthetic REV-ERB agonist

    Energy Technology Data Exchange (ETDEWEB)

    Sitaula, Sadichha [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Billon, Cyrielle [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States); Kamenecka, Theodore M.; Solt, Laura A. [Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458 (United States); Burris, Thomas P., E-mail: burristp@slu.edu [Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104 (United States)

    2015-05-08

    The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

  10. Administrative Circular No. 14 (Rev. 2)

    CERN Document Server

    HR Department

    2007-01-01

    The HR Department wishes to draw the attention of members of the personnel to a number of amendments to Administrative Circular No. 14 (Rev. 2) entitled "Protection of members of the personnel against the financial consequences of illness, accident and disability" which came into force on 1st July 2006 (cf. Weekly Bulletin of 14 and 21 August 2006). Occupational Accident Declaration Form (HS50) https://cern.ch/service-procedures/AdminMan/Forms/HS50E.doc •\tIt must be completed within 10 working days of the date on which the accident occurred (§ 29.2.1), unless the person concerned is materially unable to meet this deadline. • The completed formula must be accompanied by a medical certificate giving details of any bodily injuries resulting from the accident (Annex 1, § 5). The medical certificate must be obtained from the doctor who has been consulted for that purpose. Benefits resulting from illnesses and accidents Medical treatment will cease to be reimbursed under ...

  11. Biallelic inactivation of REV7 is associated with Fanconi anemia.

    Science.gov (United States)

    Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean

    2016-09-01

    Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

  12. Analysis of translesion DNA synthesis activity of the human REV1-REV7 complex, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Y.; Masuda, K.; Kamiya, K.

    2003-01-01

    Full text: Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 and REV7 genes are induction of mutations and prevention of cell death caused by ionizing radiation. With yeast Saccharomyces cerevisiae, results from a variety of investigations have demonstrated that the REV genes play a major role in induction of mutations through replication processes which directly copy the damaged DNA template during DNA replication. However, in higher eucaryotes, functions of homologues are poorly understood and appear somewhat different from the yeast case. It has been suggested that human REV1 interacts with human REV7, this being specific to higher eucaryotes. Here we show that purified human REV1 and REV7 proteins form a heterodimer in solution, which is stable through intensive purification steps. Results from biochemical analysis of the transferase reactions of the REV1-REV7 complex demonstrated, in contrast to the case of yeast Rev3 whose polymerase activity is stimulated by assembly with yeast Rev7, that human REV7 did not influence the stability, substrate specificity or kinetic parameters of the transferase reactions of REV1 protein. A possible molecular role of the REV7 subunit may be to help assembly of the REV1 protein to a large complex containing REV3 and/or other DNA polymerases in higher eucaryotes

  13. Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

    International Nuclear Information System (INIS)

    Wolff, Horst; Hadian, Kamyar; Ziegler, Manja; Weierich, Claudia; Kramer-Hammerle, Susanne; Kleinschmidt, Andrea; Erfle, Volker; Brack-Werner, Ruth

    2006-01-01

    The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of Rev and its functional activity in living cells. A triple-fluorescent imaging assay, called AQ-FIND, was established for automatic quantitative evaluation of nucleocytoplasmic distribution of fluorescently tagged proteins. This assay was used to screen 500 rev genes generated by error-prone PCR for Rev mutants with different localization phenotypes. Activities of the Rev mutants were determined with a second quantitative, dual-fluorescent reporter assay. In HeLa cells, the majority of nuclear Rev mutants had activities similar to wild-type Rev. The activities of Rev mutants with abnormal cytoplasmic localization ranged from moderately impaired to nonfunctional. There was no linear correlation between subcellular distribution and levels of Rev activity. In astrocytes, nuclear Rev mutants showed similar impaired activities as the cytoplasmic wild-type Rev. Our data suggest that steady-state subcellular localization is not a primary regulator of Rev activity but may change as a secondary consequence of altered Rev function. The methodologies described here have potential for studying the significance of subcellular localization for functions of other regulatory factors

  14. Wave power plant at Horns Rev. Screening[Denmark]; Boelgekraftanlaeg ved Horns Rev. Screening

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Hans C.; Nielsen, Kim; Steenstrup, P.R.; Friis-Madsen, E.; Wigant, L.

    2005-12-15

    The objective for the analysis has been to establish data for the sea at Horns Rev wind farm in the North Sea in order to assess the opportunity for using the site as test site for demonstration of wave energy devices exemplified by three different devices under development in Denmark. For comparison alternative sites like Hanstholm, Samsoe and Nissum Bredning are also assessed as well as the test centre EMEC at the Orkney Islands and the proposed test site Wave Hub at the north coast of Cornwall. The analysis shows that it is possible without major technical problems to connect 2-4 MW power generated by 3 different wave energy devices (AquaBuOY, Wave Star Energy and Wave Dragon) to the wind farm at Horns Rev (www.hornsrev.dk). The expenses for connection and regulation within the wind farm is about 200,000 DKK (30,00 EURO). On top of this comes the cost for individual sub sea cable connection to the wave devices, pull in of the sub sea cable through the existing J-tube in turbine T04 and the necessary regulation/control system in the individual wave devices to avoid damaging the power system in case of too high production. The analysis of the co-production of wind and wave power is dealt with in a separate report which shows that over a time period of half to one hour the time variation for wind generated electricity is 3 times as large as for wave energy generated power based on the actual measurement at Horns Rev. Further on the analysis shows that the wave generated power is more predictable than wind energy generated power as the power from the waves first is present about 2 hours after the wind is acting and last for 3 to 6 hours after the wind dies out; 6 to 12 hours with wind from west. The time is off course strongly depending of the direction of the wind i.e. the fetch. As this special report has a more general scope than the analysis as such it is reported in English (Annex Report II). The analysis shows that it is up to the individual device developer

  15. Administrative Circular N° 26 (Rev.  5) - November 2004

    CERN Multimedia

    Human Resources Department

    2004-01-01

    Procedure governing the career evolution of staff members The introduction of an electronic individual appraisal report form via EDH for the MAPS exercise entails some modifications to Administrative Circular N° 26 (Rev. 4). The revised version (Rev. 5) is available in departmental secretariats as well as on the Web at the following address: http://cern.ch/hr-web/internal/admin_services/admincirc/listadmincirc.asp Human Resources Department Tel. 74128

  16. Altered Sleep Homeostasis in Rev-erbα Knockout Mice.

    Science.gov (United States)

    Mang, Géraldine M; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A; Albrecht, Urs; Franken, Paul

    2016-03-01

    The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequences of a loss of REV-ERBα on the homeostatic regulation of sleep. EEG/EMG signals were recorded in Rev-erbα knockout (KO) mice and their wild type (WT) littermates during baseline, sleep deprivation, and recovery. Cortical gene expression measurements after sleep deprivation were contrasted to baseline. Although baseline sleep/wake duration was remarkably similar, KO mice showed an advance of the sleep/wake distribution relative to the light-dark cycle. After sleep onset in baseline and after sleep deprivation, both EEG delta power (1-4 Hz) and sleep consolidation were reduced in KO mice indicating a slower increase of homeostatic sleep need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to sleep onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM sleep. Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain. Our results add further proof to the notion that clock genes are involved in sleep homeostasis. Because accumulating evidence directly links REV-ERBα to dopamine signaling the altered homeostatic regulation of sleep reported here are discussed in that context. © 2016 Associated Professional Sleep Societies, LLC.

  17. Binding and thermodynamics of REV peptide-ctDNA interaction.

    Science.gov (United States)

    Upadhyay, Santosh Kumar

    2017-03-01

    The thermodynamics of DNA-ligand binding is important as it provides useful information to understand the details of binding processes. HIV-1 REV response element (RRE) located in the env coding region of the viral genome is reported to be well conserved across different HIV-1 isolates. In this study, the binding characteristics of Calf thymus DNA (ctDNA) and REV peptide from HIV-1 were investigated using spectroscopic (UV-visible, fluorescence, and circular dichroism (CD)) and isothermal titration calorimetric (ITC) techniques. Thermal stability and ligand binding properties of the ctDNA revealed that native ctDNA had a T m of 75.5 °C, whereas the ctDNA-REV peptide complex exhibited an incremental shift in the T m by 8 °C, indicating thermal stability of the complex. CD data indicated increased ellipticity due to large conformational changes in ctDNA molecule upon binding with REV peptide and two binding stoichiometric modes are apparent. The ctDNA experienced condensation due to large conformational changes in the presence of REV peptide and positive B→Ψ transition was observed at higher molar charge ratios. Fluorescence studies performed at several ligand concentrations revealed a gradual decrease in the fluorescence intensity of EtBr-bound ctDNA in response to increasing ligand concentrations. The fluorescence data further confirmed two stoichiometric modes of binding for ctDNA-REV peptide complex as previously observed with CD studies. The binding enthalpies were determined using ITC in the temperature range of 293 K-308 K. The ITC binding isotherm was exothermic at all temperatures examined, with low ΔH values indicating that the ctDNA-REV peptide interaction is driven largely by entropy. The heat capacity change (ΔC p ) was insignificant, an unusual finding in the area of DNA-peptide interaction studies. The variation in the values obtained for ΔH, ΔS, and ΔG with temperature further suggests that ctDNA-REV peptide interaction is entropically

  18. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-01-01

    The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised.

  19. Administrative Circular No. 26 (Rev. 9) – Recognition of Merit

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 26 (Rev. 9) entitled "Recognition of Merit”, approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 September 2011 is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp The circular was above all revised in order to integrate the new CERN Competency Model into the annual procedure of performance appraisal. It cancels and replaces Administrative Circular No. 26 (Rev. 8) entitled "Recognition of merit” of September 2008. Department Head Office HR Department

  20. Administrative Circular No. 26 (Rev. 7) – May 2007

    CERN Multimedia

    HR Department

    2007-01-01

    Recognition of Merit of Staff Members Administrative Circular No. 26 (Rev. 7) is now available on the intranet site of the Human Resources Department. This circular cancels and replaces Administrative Circular No. 26 (Rev. 6) - Procedures governing the career development of staff members. Copies will shortly be available in Departmental secretariats. If you require any additional information on the new staff-member merit assessment and recognition system, you may consult the FAQ, which has been available on the Human Resources Department intranet site since February 2007. Human Resources Department Tel. 78003

  1. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import.

    LENUS (Irish Health Repository)

    Gu, Lili

    2011-03-14

    Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein) as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  2. Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

    Directory of Open Access Journals (Sweden)

    Sheehy Noreen

    2011-03-01

    Full Text Available Abstract Background The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS by multiple import factors, which include transportin and importin β. However, it remains unclear which nuclear import pathway(s predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised. Results In our study, we have identified the cellular protein HIC (Human I-mfa domain-Containing protein as a novel interactor of HIV-1 Rev. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin β and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. Hence, the molecular determinants mediating Rev-NLS recognition by importin β and transportin appear to be distinct. Furthermore, we have employed HIC and M9 M, a peptide specifically designed to inhibit the transportin-mediated nuclear import pathway, to characterise Rev nuclear import pathways within different cellular environments. Remarkably, we could show that in 293T, HeLa, COS7, Jurkat, U937, THP-1 and CEM cells, Rev nuclear import is cell type specific and alternatively mediated by transportin or importin β, in a mutually exclusive fashion. Conclusions Rev cytoplasmic sequestration by HIC may represent a novel mechanism for the control of Rev function. These studies highlight that the multivalent nature of the Rev NLS for different import receptors enables Rev to adapt its nuclear trafficking strategy.

  3. A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev

    International Nuclear Information System (INIS)

    Fang Jianhua; Kubota, Satoshi; Yang Bin; Zhou Naiming; Zhang Hui; Godbout, Roseline; Pomerantz, Roger J.

    2004-01-01

    HIV-1 Rev escorts unspliced viral mRNAs out of the nucleus of infected cells, which allows formation of infectious HIV-1 virions. We have identified a putative DEAD box (Asp-Glu-Ala-Asp) RNA helicase, DDX1, as a cellular co-factor of Rev, through yeast and mammalian two-hybrid systems using the N-terminal motif of Rev as 'bait'. DDX1 is not a functional homolog of HIV-1 Rev, but down-regulation of DDX1 resulted in an alternative splicing pattern of Rev-responsive element (RRE)-containing mRNA, and attenuation of Gag p24 antigen production from HLfb rev(-) cells rescued by exogenous Rev. Co-transfection of a DDX1 expression vector with HIV-1 significantly increased viral production. DDX1 binding to Rev, as well as to the RRE, strongly suggest that DDX1 affects Rev function through the Rev-RRE axis. Moreover, down-regulation of DDX1 altered the steady state subcellular distribution of Rev, from nuclear/nucleolar to cytoplasmic dominance. These findings indicate that DDX1 is a critical cellular co-factor for Rev function, which maintains the proper subcellular distribution of this lentiviral regulatory protein. Therefore, alterations in DDX1-Rev interactions could induce HIV-1 persistence and targeting DDX1 may lead to rationally designed and novel anti-HIV-1 strategies and therapeutics

  4. Operational circular No. 1 (Rev. 1) – Operational circulars

    CERN Multimedia

    HR Department

    2011-01-01

    Operational Circular No. 1 (Rev. 1) is applicable to members of the personnel and other persons concerned. Operational Circular No. 1 (Rev. 1) entitled "Operational circulars", approved following discussion at the Standing Concertation Committee meeting on 4 May 2011, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 1 entitled "Operational Circulars” of December 1996. This new version clarifies, in particular, that operational circulars do not necessarily arise from the Staff Rules and Regulations, and the functional titles have been updated to bring them into line with the current CERN organigram. Department Head Office  

  5. Administrative Circular No. 26 (Rev.10) - Recognition of merit

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 26 (Rev. 10) entitled “Recognition of Merit”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to staff members. It cancels and replaces Administrative Circular No. 26 (Rev. 9) entitled “Recognition of Merit” of December 2011. The circular was revised in order to take into account the work performed in the framework of an elective mandate during the exercise of merit recognition of staff members. In addition, the circular was revised to provide that, in the case of staff members on special leave for professional reasons for a period equal to or longer than half a year, it will no longer be possible to grant an exceptional advancement. Department Head Office HR Department

  6. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Document Server

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  7. Meteorological explanation of wake clouds at Horns Rev wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Emeis, S. [Karlsruhe Institute of Technology (Germany). Inst. for Meteorology and Climate Research

    2010-08-15

    The occurrence of wake clouds at Horns Rev wind farm is explained as mixing fog. Mixing fog forms when two nearly saturated air masses with different temperature are mixed. Due to the non-linearity of the dependence of the saturation water vapour pressure on temperature, the mixed air mass is over-saturated and condensation sets in. On the day in February 2008, when the wake clouds were observed at Horns Rev, cold and very humid air was advected from the nearby land over the warmer North Sea and led to the formation of a shallow layer with sea smoke or fog close above the sea surface. The turbines mixed a much deeper layer and thus provoked the formation of cloud trails in the wakes of the turbines. (orig.)

  8. REV-ERB and ROR: therapeutic targets for treating myopathies

    Science.gov (United States)

    Welch, Ryan D.; Flaveny, Colin A.

    2017-08-01

    Muscle is primarily known for its mechanical roles in locomotion, maintenance of posture, and regulation of cardiac and respiratory function. There are numerous medical conditions that adversely affect muscle, myopathies that disrupt muscle development, regeneration and protein turnover to detrimental effect. Skeletal muscle is also a vital secretory organ that regulates thermogenesis, inflammatory signaling and directs context specific global metabolic changes in energy substrate preference on a daily basis. Myopathies differ in the causative factors that drive them but share common features including severe reduction in quality of life and significantly increased mortality all due irrefutably to the loss of muscle mass. Thus far clinically viable approaches for preserving muscle proteins and stimulating new muscle growth without unwanted side effects or limited efficacy has been elusive. Over the last few decades, evidence has emerged through in vitro and in vivo studies that suggest the nuclear receptors REV-ERB and ROR might modulate pathways involved in myogenesis and mitochondrial biogenesis. Hinting that REV-ERB and ROR might be targeted to treat myopathies. However there is still a need for substantial investigation into the roles of these nuclear receptors in in vivo rodent models of degenerative muscle diseases and acute injury. Although exciting, REV-ERB and ROR have somewhat confounding roles in muscle physiology and therefore more studies utilizing in vivo models of skeletal muscle myopathies are needed. In this review we highlight the molecular forces driving some of the major degenerative muscular diseases and showcase two promising molecular targets that may have the potential to treat myopathies: ROR and REV-ERB.

  9. ENDF/B-5 Fission Products Library. Rev. 2

    International Nuclear Information System (INIS)

    Schwerer, O.; Pronyaev, V.G.; Lemmel, H.D.

    1984-07-01

    This document summarizes contents and documentation of the 1984 version of the Fission Products Nuclear Data File of the ENDF/B-5 Library (Rev. 2) maintained by the National Nuclear Data Center (NNDC) at the Brookhaven National Laboratory, USA. This file contains numerical neutron reaction data and decay data for 877 fission product nuclides. The entire file or selective retrievals from it can be obtained on magnetic tape from the IAEA Nuclear Data Section. (author)

  10. Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

    Science.gov (United States)

    Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

    2017-02-01

    HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

  11. Administrative Circulars No. 12 A (Rev. 2) - "Education fees” and No. 12 B (Rev. 2) - “Education fees and language courses”

    CERN Multimedia

    2013-01-01

    Administrative Circulars No. 12 A (Rev. 2) entitled “Education fees” and No. 12 B (Rev. 2) entitled “Education fees and language courses”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, are available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 12 A (Rev. 2) is applicable to Staff Members (except former “Local Staff Members”) recruited before 1st January 2007. Administrative Circular No. 12 B (Rev. 2) is applicable to Staff Members recruited on or after 1st January 2007, to Fellows, to Scientific Associates, to Guest Professors and to former “Local Staff” recruited before 1st January 2007. They cancel and replace Administrative Circulars No. 12 A (Rev. 1/Corr.) entitled "Education fees” and No. 12 B (Rev. 1/Corr.) entitled “Edu...

  12. Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.

    Science.gov (United States)

    Bogerd, H P; Wiegand, H L; Yang, J; Cullen, B R

    2000-10-01

    Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the approximately 25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.

  13. UV-induced reversion of his4 frameshift mutations in rad6, rev1, and rev3 mutants of yeast.

    Science.gov (United States)

    Lawrence, C W; O'Brien, T; Bond, J

    1984-01-01

    The UV-induced reversion of two his4 frameshift alleles was much reduced in rad6 mutants of Saccharomyces cerevisiae, an observation that is consistent with the hypothesis that RAD6 function is required for the induction of all types of genetic alteration in misrepair mutagenesis. The reversion of these his4 alleles, together with two others of the same type, was also reduced in rev1 and rev3 mutant strains; in these, however, the extent of the reduction varied considerably with test allele used, in a manner analogous to the results in these strains for base repair substitution test alleles. The general features of UV-induced frameshift and substitution mutagenesis therefore appear quite similar, indicating that they may depend on related processes. If this conclusion is correct, greater attention must be given to integrating models which account for the production of nucleotide additions and deletions into those concerning misrepair mutagenesis.

  14. Sampling and estimation techniques for the implementation of new classification systems: the change-over from NACE Rev. 1.1 to NACE Rev. 2 in business surveys

    Directory of Open Access Journals (Sweden)

    Jan van den Brakel

    2010-09-01

    Full Text Available This paper describes some of the methodological problems encountered with the change-over from the NACE Rev. 1.1 to the NACE Rev. 2 in business statistics. Different sampling and estimation strategies are proposed to produce reliable figures for the domains under both classifications simultaneously. Furthermore several methods are described that can be used to reconstruct time series for the domains under the NACE Rev. 2.

  15. Repository Surface Design Engineering Files Report Rev 00 ICN 1

    International Nuclear Information System (INIS)

    2001-01-01

    The objective of the Repository Surface Design Engineering Files Report Supplement [herein known as the Engineering Files (EF)] is to provide the surface design data needed by the Environmental Impact Statement (EIS) contractor to prepare the EIS and evaluate options and alternatives. This document is based on the Repository Surface Design Engineering Files Report, Revision 03 (CRWMS M and O 1999f) (EF Rev 03). Where facility and system designs have been changed for the Site Recommendation (SR) effort they are described in this report. EIS information provided in this report includes the following: (1) Description of program phases; there are no changes that impact this report. (2) A description of the major design requirements and assumptions that drive the surface facilities reference design is provided herein (Section 2.2), including the surface design resulting from recommendations regarding Enhanced Design Alternative (EDA) II, as discussed in the License Application Design Section Report (CRWMS M and O 1999d), and changes to the waste stream. See Section 2, Table 2-2, for the SR waste stream. (3) The major design requirements and assumptions that drive the surface facilities reference design are by reference to EF Rev 03; there are no changes that impact this report. (4) Description of the reference design concept and existing site conditions is by reference to EF Rev 03 (including Table 4-1, which is not included in this supplement); there are no changes that impact this report. (5) Description of alternative design cases is by reference to EF Rev 03; there are no changes that impact this report. (6) Description of optional inventory modules is by reference to EF Rev 03; there are no changes that impact this report. (7) Tabular summary level engineering values (i.e., staffing, wastes, emissions, resources, and land use) for the reference design and the alternative design cases that address construction, emplacement operations, caretaker operations, and

  16. Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas

    Science.gov (United States)

    New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center

  17. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    International Nuclear Information System (INIS)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang; Liu, Chao; Zhang, Hui

    2015-01-01

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  18. RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Liu, Chao, E-mail: liuchao9@mail.sysu.edu.cn [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Zhang, Hui [Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China); Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)

    2015-12-15

    Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.

  19. Wind Farm Wake: The Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Rasmussen, Leif; Peña, Alfredo

    2013-01-01

    The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surf...... in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog....

  20. Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.

    Directory of Open Access Journals (Sweden)

    Thomas Vercruysse

    Full Text Available HIV-1 Rev is the key protein in the nucleocytoplasmic export and expression of the late viral mRNAs. An important aspect for its function is its ability to multimerize on these mRNAs. We have recently identified a llama single-domain antibody (Nb190 as the first inhibitor targeting the Rev multimerization function in cells. This nanobody is a potent intracellular antibody that efficiently inhibits HIV-1 viral production. In order to gain insight into the Nb190-Rev interaction interface, we performed mutational and docking studies to map the interface between the nanobody paratope and the Rev epitope. Alanine mutants of the hyper-variable domains of Nb190 and the Rev multimerization domains were evaluated in different assays measuring Nb190-Rev interaction or viral production. Seven residues within Nb190 and five Rev residues are demonstrated to be crucial for epitope recognition. These experimental data were used to perform docking experiments and map the Nb190-Rev structural interface. This Nb190-Rev interaction model can guide further studies of the Nb190 effect on HIV-1 Rev function and could serve as starting point for the rational development of smaller entities binding to the Nb190 epitope, aimed at interfering with protein-protein interactions of the Rev N-terminal domain.

  1. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion in the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  2. Publication Of Administrative Circulars: No. 4 (Rev. 4) – Unemployment Insurance Scheme No. 30 (Rev. 2) – Financial Benefits on Taking Up Appointment and on Termination of Contract

    CERN Document Server

    HR Department

    2008-01-01

    Administrative Circular No. 4 (Rev. 4) – Unemployment insurance scheme Administrative Circular No. 4 (Rev. 4) – "Unemployment insurance scheme", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 4 (Rev. 3) – "Unemployment insurance" of October 1993. Copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003 Administrative Circular No. 30 (Rev. 2) – Financial benefits on taking up appointment and termination of contract Administrative Circular No. 30 (Rev. 2) – "Financial benefits on taking up appointment and termination of contract", approved following discussion at the Standing Concertation Committee meetings of 28 August 2007 and 27 February 2008, is now available on the intranet site of the Human Resources De...

  3. 12MW Horns Rev experiment[Wind farm

    Energy Technology Data Exchange (ETDEWEB)

    Hasager, C.B.; Pena, A; Mikkelsen, T.; Courtney, M.; Antoniou, I.; Gryning, S.-E.; Hansen, P. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Soerensen, P.B. [DONG Energy (Denmark)

    2007-10-15

    The 12MW project with the full title '12 MW wind turbines: the scientific basis for their operation at 70 to 270 m height offshore' has the goal to experimentally investigate the wind and turbulence characteristics between 70 and 270 m above sea level and thereby establish the scientific basis relevant for the next generation of huge 12 MW wind turbines operating offshore. The report describes the experimental campaign at the Horns Rev offshore wind farm at which observations from Doppler Laser LIDAR and SODAR were collected from 3 May to 24 October 2006. The challenges for mounting and operating the instruments on the transformer platform at Horns Rev were overcome by a close collaboration between DONG energy and Risoe National Laboratory DTU. The site is presented. In particular, three tall offshore meteorological masts, up to 70 m tall, provided a useful source of meteorological data for comparison to the remotely sensed wind and turbulence observations. The comparison showed high correlation. The LIDAR and SODAR wind and turbulence observations were collected far beyond the height of the masts (up to 160 m above sea level) and the extended profiles were compared to the logarithmic wind profile. Further studies on this part of the work are on-going. Technical detail on LIDAR and SODAR are provided as well as theoretical work on turbulence and atmospheric boundary layer flow. Selected results from the experimental campaign are reported. (au)

  4. Wind Farm Wake: The 2016 Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Charlotte Bay Hasager

    2017-03-01

    Full Text Available Offshore wind farm wakes were observed and photographed in foggy conditions at Horns Rev 2 on 25 January 2016 at 12:45 UTC. These new images show highly contrasting conditions regarding the wind speed, turbulence intensity, atmospheric stability, weather conditions and wind farm wake development as compared to the Horns Rev 1 photographs from 12 February 2008. The paper examines the atmospheric conditions from satellite images, radiosondes, lidar and wind turbine data and compares the observations to results from atmospheric meso-scale modelling and large eddy simulation. Key findings are that a humid and warm air mass was advected from the southwest over cold sea and the dew-point temperature was such that cold-water advection fog formed in a shallow layer. The flow was stably stratified and the freestream wind speed was 13 m/s at hub height, which means that most turbines produced at or near rated power. The wind direction was southwesterly and long, narrow wakes persisted several rotor diameters downwind of the wind turbines. Eventually mixing of warm air from aloft dispersed the fog in the far wake region of the wind farm.

  5. rev piyasaları ve vergilendirilmesi

    OpenAIRE

    İşler, İsmail; Utku, Mehmet

    2015-01-01

    rev piyasaları kavramı, vadeli işlem sözleşmeleri (forward, futures), opsiyon sözleşmeleri, swap sözleşmeleri ve aracı kuruluş varantları işlemlerinin tamamını içermektedir. Bu tür işlemler vadeli işlemlerdir. Vadeli işlemlerin ortak özelliği, ilerideki bir tarihte teslimatı yapılmak üzere herhangi bir malın veya finansal aracın, bugünden alım satımının yapılmasıdır. Bu çalışmada türev araçların tanımları ve vergilendirilmeleri örneklerle açıklanacaktır. The term derivatives market invol...

  6. Applications of the INFCIRC225/rev5 to the national physical protection regime

    International Nuclear Information System (INIS)

    Kim, Jae Gwang

    2011-01-01

    The IAEA's first effort for playing a key role in physical protection of nuclear material and facilities resulted in the publication of 'Recommendations for the physical protection of nuclear material' in 1972. These recommendations were revised by a group of experts in co-operation with the IAEA Secretariat and the revised version was published in 1975 in INFCIRC/225. The document was subsequently revised in 1977(rev.1), 1989(rev.2), in 1993(rev.3) and 1998(rev4). The Physical Protection regime in ROK has been established on the basis of INFCIRC225 rev4 since 2004 IAEA recently published The INFCIRC 225 rev5 through the 2 years expert consultations. The publication recommended 12 nuclear security fundamentals and requirements of physical protection of nuclear material and nuclear facility to the member states. This paper suggests the several applications to the national physical protection system from the 12 fundamentals and the requirements

  7. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee at its meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  8. Publication of administrative circular No. 26 (Rev. 8) – Recognition of merit

    CERN Multimedia

    HR Department

    2008-01-01

    Administrative Circular No. 26 (Rev. 8) – Recognition of merit Administrative Circular No. 26 (Rev. 8) – "Recognition of merit", approved by the Standing Concertation Committee meeting on 3 September 2008, is now available on the intranet site of the Human Resources Department. It cancels and replaces Administrative Circular No. 26 (Rev. 7) – "Recognition of merit of staff members" of May 2007. Paper copies will shortly be available in Departmental secretariats. Human Resources Department Tel. 78003

  9. REV7, a new gene concerned with UV mutagenesis in yeast

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-01-01

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. Rev7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX. (orig.)

  10. REV7, a new gene concerned with UV mutagenesis in yeast

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, C.W.; Das, G.; Christensen, R.B.

    1985-06-26

    Three allelic mutations of a new yeast gene, which we have named REV7, have been isolated by testing 313 methyl methane sulfonate sensitive mutants for UV-induced reversion of a lys2 allele. REV7 mutants are markedly deficient with respect to UV-induced reversion of lys2, are slightly sensitive to UV and appear to be in the RAD6 epistasis group for UV survival. Rev7-1, which is probably an amber mutation, does not appear to affect sporulation in homozygous diploids. The REV7 gene is located about 12 cM distal to HIS5 on chromosome IX.

  11. Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells

    Energy Technology Data Exchange (ETDEWEB)

    Heidenreich, Erich [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)]. E-mail: erich.heidenreich@meduniwien.ac.at; Eisler, Herfried [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria); Steinboeck, Ferdinand [Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna (Austria)

    2006-01-29

    Mutations arising in times of cell cycle arrest may provide a selective advantage for unicellular organisms adapting to environmental changes. For multicellular organisms, however, they may pose a serious threat, in that such mutations in somatic cells contribute to carcinogenesis and ageing. The budding yeast Saccharomyces cerevisiae presents a convenient model system for studying the incidence and the mechanisms of stationary-phase mutation in a eukaryotic organism. Having studied the emergence of frameshift mutants after several days of starvation-induced cell cycle arrest, we previously reported that all (potentially error-prone) translesion synthesis (TLS) enzymes identified in S. cerevisiae did not contribute to the basal level of spontaneous stationary-phase mutations. However, we observed that an increased frequency of stationary-phase frameshift mutations, brought about by a defective nucleotide excision repair (NER) pathway or by UV irradiation, was dependent on Rev3p, the catalytic subunit of the TLS polymerase zeta (Pol {zeta}). Employing the same two conditions, we now examined the effect of deletions of the genes coding for polymerase eta (Pol {eta}) (RAD30) and Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moderately influenced by a lack of Pol {eta} but completely reduced to wild type level by a knockout of the REV1 gene. UV-induced stationary-phase mutations were abundant in wild type and rad30{delta} strains, but substantially reduced in a rev1{delta} as well as a rev3{delta} strain. The similarity of the rev1{delta} and the rev3{delta} phenotype and an epistatic relationship evident from experiments with a double-deficient strain suggests a participation of Rev1p and Rev3p in the same mutagenic pathway. Based on these results, we propose that the response of cell cycle-arrested cells to an excess of exo- or endogenously induced DNA damage includes a novel replication

  12. SSC-K code users manual (rev.1)

    International Nuclear Information System (INIS)

    Kwon, Y. M.; Lee, Y. B.; Chang, W. P.; Hahn, D.

    2002-01-01

    The Supper System Code of KAERI (SSC-K) is a best-estimate system code for analyzing a variety of off-normal or accidents in the heat transport system of a pool type LMR design. It is being developed at Korea Atomic Energy Research Institution (KAERI) on the basis of SSC-L, originally developed at BNL to analyze loop-type LMR transients. SSC-K can handle both designs of loop and pool type LMRs. SSC-K contains detailed mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, coolant, fuel elements, and structures to accident conditions. This report provides a revised User's Manual (rev.1) of the SSC-K computer code, focusing on phenomenological model descriptions for new thermal, hydraulic, neutronic, and mechanical modules. A comprehensive description of the models for pool-type reactor is given in Chapters 2 and 3; the steady-state plant characterization, prior to the initiation of transient is described in Chapter 2 and their transient counterparts are discussed in Chapter 3. Discussions on the intermediate heat exchanger (IHX) and the electromagnetic (EM) pump are described in Chapter 4 and 5, respectively. A model of passive safety decay heat removal system (PSDRS) is discussed in Chapter 6, and models for various reactivity feedback effects are discussed in Chapter 7. In Chapter 8, constitutive laws and correlations required to execute the SSC-K are described. New models developed for SSC-K rev.1 are two dimensional hot pool model in Chapter 9, and long term cooling model in Chapter 10. Finally, a brief description of MINET code adopted to simulate BOP is presented in Chapter 11. Based on test runs for typical LMFBR accident analyses, it was found that the present version of SSC-K would be used for the safety analysis of KALIMER. However, the further validation of SSC-K is required for real applications. It is noted that the user's manual of SSC-K will be revised later with the

  13. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.

    Science.gov (United States)

    Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok

    2017-09-16

    Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. RevManHAL: towards automatic text generation in systematic reviews.

    Science.gov (United States)

    Torres Torres, Mercedes; Adams, Clive E

    2017-02-09

    Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.

  15. Wind Farm Wake: The Horns Rev Photo Case

    Directory of Open Access Journals (Sweden)

    Pierre-Elouan Réthoré

    2013-02-01

    Full Text Available The aim of the paper is to examine the nowadays well-known wind farm wake photographs taken on 12 February 2008 at the offshore Horns Rev 1 wind farm. The meteorological conditions are described from observations from several satellite sensors quantifying clouds, surface wind vectors and sea surface temperature as well as ground-based information at and near the wind farm, including Supervisory Control and Data Acquisition (SCADA data. The SCADA data reveal that the case of fog formation occurred 12 February 2008 on the 10:10 UTC. The fog formation is due to very special atmospheric conditions where a layer of cold humid air above a warmer sea surface re-condensates to fog in the wake of the turbines. The process is fed by warm humid air up-drafted from below in the counter-rotating swirl generated by the clock-wise rotating rotors. The condensation appears to take place primarily in the wake regions with relatively high axial velocities and high turbulent kinetic energy. The wind speed is near cut-in and most turbines produce very little power. The rotational pattern of spiraling bands produces the large-scale structure of the wake fog.

  16. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    International Nuclear Information System (INIS)

    Kula, Anna; Gharu, Lavina; Marcello, Alessandro

    2013-01-01

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  17. Caffeine Abolishes the Ultraviolet-Induced REV3 Translesion Replication Pathway in Mouse Cells

    Directory of Open Access Journals (Sweden)

    Kouichi Yamada

    2011-11-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a photoproduct on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion. Using an alkaline sucrose density gradient sedimentation technique, we previously classified this process termed UV-induced translesion replication (UV-TLS into two types. In human cancer cells or xeroderma pigmentosum variant (XP-V cells, UV-TLS was inhibited by caffeine or proteasome inhibitors. However, in normal human cells, the process was insensitive to these reagents. Reportedly, in yeast or mammalian cells, REV3 protein (a catalytic subunit of DNA polymerase ζ is predominantly involved in the former type of TLS. Here, we studied UV-TLS in fibroblasts derived from the Rev3-knockout mouse embryo (Rev3KO-MEF. In the wild-type MEF, UV-TLS was slow (similar to that of human cancer cells or XP-V cells, and was abolished by caffeine or MG-262. In 2 cell lines of Rev3KO-MEF (Rev3−/− p53−/−, UV-TLS was not observed. In p53KO-MEF, which is a strict control for Rev3KO-MEF, the UV-TLS response was similar to that of the wild-type. Introduction of the Rev3 expression plasmid into Rev3KO-MEF restored the UV-TLS response in selected stable transformants. In some transformants, viability to UV was the same as that in the wild-type, and the death rate was increased by caffeine. Our findings indicate that REV3 is predominantly involved in UV-TLS in mouse cells, and that the REV3 translesion pathway is suppressed by caffeine or proteasome inhibitors.

  18. Mining the Human Complexome Database Identifies RBM14 as an XPO1-Associated Protein Involved in HIV-1 Rev Function

    OpenAIRE

    Budhiraja, Sona; Liu, Hongbing; Couturier, Jacob; Malovannaya, Anna; Qin, Jun; Lewis, Dorothy E.; Rice, Andrew P.

    2015-01-01

    By recruiting the host protein XPO1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts. We mined data from the recently described human nuclear complexome to identify a host protein, RBM14, which associates with XPO1 and Rev and is involved in Rev function. Using a Rev-dependent p24 reporter plasmid, we found that RBM14 depletion decreased Rev activity and Rev-mediated enhancement of the cytoplasmic levels of unspliced viral transcripts. RBM14 ...

  19. Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cleasby, Mark E. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Millard, Susan; Leong, Gary M. [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia); Cooney, Gregory J. [Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St. Vincent' s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010 (Australia); Muscat, George E.O., E-mail: g.muscat@imb.uq.edu.au [The University of Queensland, Institute for Molecular Bioscience, St. Lucia, Qld 4072 (Australia)

    2009-10-30

    The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, a previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.

  20. TEN YEARS OF THE NORTHEASTERN NURSING NETWORK JOURNAL - REV RENE: A DREAM COME TRUE

    Directory of Open Access Journals (Sweden)

    Inacia Sátiro Xavier de Franca

    2011-01-01

    Full Text Available Objetivou-se analisar a memória histórica da Rev Rene ao longo de uma década de sua existência destacando a sua organização, a produção científica e as conquistas alcançadas no concernente a sua indexação nas bases de dados. Estudo fenomenológico cujos dados foram coletados por meio de um formulário, submetidos a associações livres e interpretados em consonância com “A poética do espaço”. Os núcleos foram: Universidade Federal do Ceará (UFC — A casa da Rev Rene; A Rev Rene — ninho — um espaço aberto aos pesquisadores da Saúde e áreas afins; Poética das gavetas do cofre e dos armários — o capital científico da Rev Rene à disposição dos leitores; A Rev Rene — concha — uma homologia poética; A Rev Rene é redonda — Metas e ações para a projeção no cenário nacional e internacional. A Rev Rene transpôs a dimensão do sonho e consolidou-se como um lócus de ciência.

  1. Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

    Directory of Open Access Journals (Sweden)

    Ryan D. Welch

    2017-07-01

    Conclusions: Disrupting Rev-Erb activity in injured muscle accelerates regenerative muscle repair/differentiation through transcriptional de-repression of myogenic programs. Rev-Erb, therefore, may be a potent therapeutic target for a myriad of muscular disorders.

  2. Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation

    Directory of Open Access Journals (Sweden)

    Jun Takezawa

    2010-01-01

    Full Text Available When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s, which insert nucleotide(s opposite the lesion, extend by a few nucleotides, and dissociate from the 3′-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS or replicative bypass, may involve at least five different polymerases in mammals, although the participating polymerases and their roles have not been entirely characterized. Using siRNAs originally designed and an alkaline sucrose density gradient sedimentation technique, we verified the involvement of several polymerases in ultraviolet (UV light-induced TLS in HeLa cells. First, siRNAs to Rev3 or Rev7 largely abolished UV-TLS, suggesting that these 2 gene products, which comprise Polζ, play a main role in mutagenic TLS. Second, Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targeted siRNA also prevented TLS to a greater extent than our expectations. Forth, although siRNA to Polι had no detectable effect, that to Polκ delayed UV-TLS. To our knowledge, this is the first study reporting apparent evidence for the participation of Polκ in UV-TLS.

  3. Teede REV-2 otsustas börsile minna / Gea Velthut-Sokka

    Index Scriptorium Estoniae

    Velthut-Sokka, Gea, 1977-

    2004-01-01

    Eelmise aasta edukaima ehitusfirma Teede REV-2 ja tema suurinvestori Alta Kapital esindajad põhjendavad börsile mineku otsust. Tabelid ja diagrammid: Veerandi aktsiate omanikuvahetus börsilemineku peaprooviks

  4. REV ÜRÜNLERİN MUHASEBELEŞTİRİLMESİ

    OpenAIRE

    YURT, Eda

    2009-01-01

    Eda, Yurt, Türev Ürünlerin Muhasebelestirilmesi, Tezsiz Yüksek Lisans Dönem Projesi,Danısman: Doç. Dr. Kadir Gürdal, 58 s.BİTİRME PROJESİ ÖZETİProje finansal araçlar olarak türev ürünlerin muhasebelestirilmesine iliskinstandartların incelenmesini amaçlamaktadır. Öncelikle finansal risk tanımlanmıstır.Daha sonra türev piyasaların tarihi anlatılmıs ve islem gördükleri piyasalara göresınıflandırılmıstır. Bu temel açıklamalar sonrasında türev ürünler için UluslararasıMuhasebe Standartları incelen...

  5. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

    International Nuclear Information System (INIS)

    Fang Jianhua; Acheampong, Edward; Dave, Rajnish; Wang Fengxiang; Mukhtar, Muhammad; Pomerantz, Roger J.

    2005-01-01

    Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

  6. Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

    Science.gov (United States)

    Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.

    2016-01-01

    The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands. Recent studies in mice suggest that REV-ERB-specific synthetic agonists modulate metabolic activity as well as alter sleep architecture, inducing wakefulness during the light period. Therefore, these small molecules represent unique tools to extensively study REV-ERB regulation of sleep and wakefulness. In these studies, our aim was to further investigate the therapeutic potential of targeting the REV-ERBs for regulation of sleep by characterizing efficacy, and optimal dosing time of the REV-ERB agonist SR9009 using electroencephalographic (EEG) recordings. Applying different experimental paradigms in mice, our studies establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop when administered once a day over a three-day dosing regimen. Moreover, through use of a time response paradigm, we determined that although there is an optimal time for administration of SR9009 in terms of maximal efficacy, there is a 12-hour window in which SR9009 elicited a response. Our studies indicate that the REV-ERBs are potential therapeutic targets for treating sleep problems as those encountered as a consequence of shift work or jet lag. PMID:27603791

  7. Offshore wind farms in the local environment - an examination at Horns Rev Offshore Wind Farm. Background report; Havvindmoeller i lokalomraadet - en undersoegelse ved Horns Rev Havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, Susanne

    2005-07-01

    Horns Rev Offshore Wind Farm was built in 2002. A presentation is made of a sociological, qualitative survey on the local community's reception of the offshore wind farm. The survey aims at identifying attitudes towards the farm before and after the construction, with a view to identifying possible changes in attitudes, and explain the reasons for these (ml)

  8. Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.

    Directory of Open Access Journals (Sweden)

    Min-Hsuan Lin

    Full Text Available Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the mechanism of this effect for the first time, establishing that redistribution of Rev by Nullbasic is not due to direct interaction between the two proteins. Rather, Nullbasic affects subcellular localization of cellular proteins that regulate Rev trafficking. In particular, Nullbasic induced redistribution of exportin 1 (CRM1, nucleophosmin (B23 and nucleolin (C23 from the nucleolus to the nucleus when Rev was coexpressed, but never in its absence. Inhibition of the Rev:CRM1 interaction by leptomycin B or a non-interacting RevM10 mutant completely blocked redistribution of Rev by Nullbasic. Finally, Nullbasic did not inhibit importin β- or transportin 1-mediated nuclear import, suggesting that cytoplasmic accumulation of Rev was due to increased export by CRM1. Overall, our data support the conclusion that CRM1-dependent subcellular redistribution of Rev from the nucleolus by Nullbasic is not through general perturbation of either nuclear import or export. Rather, Nullbasic appears to interact with and disrupt specific components of a Rev trafficking complex required for its nucleocytoplasmic shuttling and, in particular, its nucleolar accumulation.

  9. Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function

    Directory of Open Access Journals (Sweden)

    St-Laurent Georges

    2006-11-01

    Full Text Available Abstract Background The HIV Rev protein is known to facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent viral transcripts, dependents on interaction of Rev with the RRE RNA structural element present in the target RNAs. The C-terminal variant of dsRNA-binding nuclear protein 90 (NF90ctv has been shown to markedly attenuate viral replication in stably transduced HIV-1 target cell line. Here we examined a mechanism of interference of viral life cycle involving Rev-NF90ctv interaction. Results Since Rev:RRE complex formations depend on protein:RNA and protein:protein interactions, we investigated whether the expression of NF90ctv might interfere with Rev-mediated export of RRE-containing transcripts. When HeLa cells expressed both NF90ctv and Rev protein, we observed that NF90ctv inhibited the Rev-mediated RNA transport. In particular, three regions of NF90ctv protein are involved in blocking Rev function. Moreover, interaction of NF90ctv with the RRE RNA resulted in the expression of a reporter protein coding sequences linked to the RRE structure. Moreover, Rev influenced the subcellular localization of NF90ctv, and this process is leptomycin B sensitive. Conclusion The dsRNA binding protein, NF90ctv competes with HIV Rev function at two levels, by competitive protein:protein interaction involving Rev binding to specific domains of NF90ctv, as well as by its binding to the RRE-RNA structure. Our results are consistent with a model of Rev-mediated HIV-1 RNA export that envisions Rev-multimerization, a process interrupted by NF90ctv.

  10. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

    Directory of Open Access Journals (Sweden)

    Gwendal Le Martelot

    2009-09-01

    Full Text Available In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coordinated by the circadian timing system. Molecular clocks are thought to rely on negative feedback loops in clock gene expression that engender oscillations in the accumulation of transcriptional regulatory proteins, such as the orphan receptor REV-ERBalpha. Circadian transcription factors then drive daily rhythms in the expression of clock-controlled output genes, for example genes encoding enzymes and regulators of cellular metabolism. To gain insight into clock output functions of REV-ERBalpha, we carried out genome-wide transcriptome profiling experiments with liver RNA from wild-type mice, Rev-erbalpha knock-out mice, or REV-ERBalpha overexpressing mice. On the basis of these genetic loss- and gain-of-function experiments, we concluded that REV-ERBalpha participates in the circadian modulation of sterol regulatory element-binding protein (SREBP activity, and thereby in the daily expression of SREBP target genes involved in cholesterol and lipid metabolism. This control is exerted via the cyclic transcription of Insig2, encoding a trans-membrane protein that sequesters SREBP proteins to the endoplasmic reticulum membranes and thereby interferes with the proteolytic activation of SREBPs in Golgi membranes. REV-ERBalpha also participates in the cyclic expression of cholesterol-7alpha-hydroxylase (CYP7A1, the rate-limiting enzyme in converting cholesterol to bile acids. Our findings suggest that this control acts via the stimulation of LXR nuclear receptors by cyclically produced oxysterols. In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry.

  11. Contributions of individual domains to function of the HIV-1 Rev response element.

    Science.gov (United States)

    O'Carroll, Ina P; Thappeta, Yashna; Fan, Lixin; Ramirez-Valdez, Edric A; Smith, Sean; Wang, Yun-Xing; Rein, Alan

    2017-08-16

    The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additional domains. We previously reported that the RRE assumes an "A" shape in solution and suggested that the location of the Rev binding sites in domains I and II, opposite each other on the two legs of the A, is optimal for Rev binding and explains Rev's specificity for RRE-containing RNAs. Using SAXS and a quantitative functional assay, we have now analyzed a panel of RRE mutants. All the results support the essential role of the A shape for RRE function. Moreover, they suggest that the distal portion of domain I and the three crowning domains all contribute to the maintenance of the A shape. Domains I and II are necessary and sufficient for substantial RRE function, provided they are joined by a flexible linker that allows the two domains to face each other. IMPORTANCE Retroviral replication requires that some of the viral RNAs transcribed in the cell nucleus be exported to the cytoplasm without being spliced. To achieve this, HIV-1 encodes a protein, Rev, which binds to a complex, highly structured element within viral RNA, the Rev Response Element (RRE), and escorts RRE-containing RNAs from the nucleus. We previously reported that the RRE is "A"-shaped and suggested that this architecture, with the 2 legs opposite one another, can explain the specificity of Rev for the RRE. We have analyzed the functional contributions of individual RRE domains, and now report that several domains contribute, with some redundancy, to maintenance of the overall RRE shape. The data strongly support the hypothesis that the opposed placement of the 2 legs is essential for RRE function. Copyright © 2017

  12. B23/nucleophosmin interacts with bovine immunodeficiency virus Rev protein and facilitates viral replication.

    Science.gov (United States)

    Passos-Castilho, Ana Maria; Marchand, Claude; Archambault, Denis

    2018-02-01

    The bovine immunodeficiency virus (BIV) Rev shuttling protein contains nuclear/nucleolar localization signals and nuclear import/export mechanisms that are novel among lentivirus Rev proteins. Several viral proteins localize to the nucleolus, which may play a role in processes that are essential to the outcome of viral replication. Although BIV Rev localizes to the nucleoli of transfected/infected cells and colocalizes with one of its major proteins, nucleophosmin (NPM1, also known as B23), the role of the nucleolus and B23 in BIV replication remains to be determined. Here, we demonstrate for the first time that BIV Rev interacts with nucleolar phosphoprotein B23 in cells. Using small interfering RNA (siRNA) technology, we show that depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication. The interaction between Rev and B23 may represent a potential new target for the development of antiviral drugs against lentiviruses. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. SEM-REV: A sea test site for Marine Energy Converter

    International Nuclear Information System (INIS)

    Berhault, Christian; Le Crom, Izan; Le Bihan, Gerard

    2015-01-01

    Thanks to a main funding of Region des Pays de la Loire, the sea test site SEM-REV has been developed by Ecole Centrale de Nantes since 2007 to test both Wave Energy Converters and Floating Wind Turbine in real sea conditions. The sea test site is equipped with a set of oceanographic sensors and with an electric cable of 8 MW, connected to the French grid. The project is located close to Le Croisic, Western coast of France. SEM-REV is one of the main test facilities operated by Ecole Centrale de Nantes to support MRE technologies development. After presenting the initial motivations of the SEM-REV development, the paper describes, in parts 1 and 2, the complete administrative and technical processes that were followed to reach SEM-REV commissioning in 2014. The third part is focused on the exploitation process, including technical and contractual specifications imposed to the MRE developers for installation, tests and decommissioning phases. Some words are given also on the R and D projects using the SEM-REV in-situ monitoring system: prediction of environmental conditions, bio-fooling, acoustic impact. Even if operational phase is not started, expected extensions of the tests site are listed. (authors)

  14. Ultraviolet-induced reversion of cyc1 alleles in radiation-sensitive strains of yeast. III. rev 3 mutant strains

    International Nuclear Information System (INIS)

    Lawrence, C.W.; Crhistensen, R.B.

    1979-01-01

    The role of rev3 gene function in uv-induced mutagenesis in the yeast Saccharomyces cerevisiae has been examined by determining the reversion of 12 well-defined cyc1 mutations in diploid strains homozygous for the rev3-1 or rev3-3 allale. The 12 cyc1 alleles include one ochre, one amber, four initiation, two proline missense, and four frameshift mutations. We find that the rev3 mutations reduce the frequency of UV-induced reversion of all of the cyc1 alleles, though different classes of alleles respond to a different extent. These results imply that the rev3 gene function is required for the production of a wide variety of mutational events, though probably not all, and show that each of the three rev loci have different mutational phenotypes. Such diverse phenotypes are not predicted by the unitary model for bacterial mutagenes, suggesting that this is at best an incomplete description of eukaryotic mutagenesis

  15. Innocuity and immune response to Brucella melitensis Rev.1 vaccine in camels (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    A. Benkirane

    2014-10-01

    Full Text Available A field trial was conducted in a camel brucellosis-free herd to evaluate antibody response to the Brucella melitensis Rev.1 vaccine in camels and assess shedding of the vaccine strain in milk. Twenty eight camels were divided into four groups according to their age and vaccination route. Groups A (n=3 and B (n=3 consisted of non-pregnant lactating female camels, vaccinated through subcutaneous and conjunctival routes, respectively. Groups C (n=10 consisted of 8-11 months old calves vaccinated through conjunctival route. The rest of the herd (n=12 composed of female and young camels were not vaccinated and were considered as the control group. Each animal from groups A, B and C was given the recommended dose of 2 x 109 colony forming units of Rev.1 vaccine irrespective of age or route of vaccination. Blood samples were collected from all the animals at the time of vaccination and at weekly, bi-weekly and monthly interval until 32 weeks post vaccination and from controls at weeks 8 and 24. The serological tests used were modified Rose Bengal Test, sero-agglutination test, and an indirect Enzyme Linked Immunosorbent Assay. Milk samples were collected from all vaccinated female camels and tested for the presence of Rev.1 vaccine strain. Most vaccinated animals started to show an antibody response at week 2 and remained positive until week 16. By week 20 post-vaccination all animals in the three groups were tested negative for Brucella antibodies. Bacteriological analysis of milk samples did not allow any isolation of Brucella melitensis. All samples were found Brucella negative in PCR analysis. The results of this study indicate that the Rev.1 vaccine induces seroconversion in camels. Rev.1 vaccine strain is not excreted in the milk of camels. These findings are promising as to the safe use of the Rev.1 vaccine in camels.

  16. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.

    Science.gov (United States)

    Tamura, Satoru; Kaneko, Masafumi; Shiomi, Atsushi; Yang, Guang-Ming; Yamaura, Toshiaki; Murakami, Nobutoshi

    2010-03-15

    Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (1) as an unprecedented NES non-antagonistic inhibitor for nuclear export of Rev. This mechanism of action was established by competitive experiment by the biotinylated probe derived from leptomycin B, the known NES antagonistic inhibitor. Additionally, structure-activity relationship analysis by use of the synthesized analogs clarified cooperation of several functionalities in the Rev-export inhibitory activity of 1. Copyright 2010 Elsevier Ltd. All rights reserved.

  17. Administrative Circular No. 22B (Rev. 2) - Compensation for hours of long-term shift work

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 22B (Rev. 2) entitled "Compensation for hours of long-term shift work",  approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208538.   This revised circular cancels and replaces Administrative Circular No. 22B (Rev. 1) also entitled "Compensation for hours of long-term shift work" of March 2011. This document contains minor changes to reflect the new career structure. This circular will enter into force on 1st September 2016.

  18. Administrative Circular No. 13 (Rev. 4) - Guarantees for representatives of the personnel

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 13 (Rev. 4) entitled "Guarantees for representatives of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208527.   This revised circular cancels and replaces Administrative Circular No. 13 (Rev. 3) also entitled "Guarantees for representatives of the personnel" of January 2014. This document contains a single change to reflect the terminology under the new career structure: the term "career path" is replaced by "grade". This circular will enter into force on 1st September 2016.

  19. Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

    DEFF Research Database (Denmark)

    Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai

    We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

  20. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P. [NERI, Dept. of Wildlife Ecology and Biodiversity, Roskilde (Denmark)

    2005-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  1. Investigations of migratory birds during operation of Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Hounisen, J.P.

    2005-01-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. The study focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging bird species. The study was based on data from spring 2004. The Horns Rev area lies in a region known to be of importance for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  2. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

    DEFF Research Database (Denmark)

    Wernersson, Rasmus; Pedersen, Anders Gorm

    2003-01-01

    The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

  3. Administrative Circular No. 11 (Rev. 4) - Categories of members of the personnel

    CERN Multimedia

    HR Department

    2016-01-01

    Administrative Circular No. 11 (Rev. 4) entitled "Categories of members of the personnel", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 29 April 2016, will be available on 1 August 2016 via this following link.    This revised circular cancels and replaces the Administrative Circular No. 11 (Rev. 3) also entitled "Categories of members of the personnel" of September 2014. The main changes concern the status of apprentices and their transfer from the category of employed members of personnel to associated members of personnel. This circular will enter into force on 1 August 2016. Department Head Office

  4. Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

    Directory of Open Access Journals (Sweden)

    Hong Zan

    2012-11-01

    Full Text Available By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID-mediated deoxycytosine deamination, yielding deoxyuridine (dU, and dU glycosylation by uracil DNA glycosylase (Ung in antibody switch (S region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1−/− Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation, and CSR. Together with an S region spectrum of mutations similar to that of Rev1+/+ Ung−/− B cells, this suggests that Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1−/− Msh2−/− B cells. Rescue of CSR in Rev1−/− B cells by a catalytically inactive Rev1 mutant shows that the important role of Rev1 in CSR is mediated by Rev1’s scaffolding function, not its enzymatic function.

  5. Metabolism and apoptotic properties of elevated ceramide in HT29(rev) cells

    NARCIS (Netherlands)

    Veldman, R J; Klappe, K; Hoekstra, D; Kok, J W

    1998-01-01

    Ceramide (Cer) has been implicated in the regulation of apoptosis. In this study, we elevated cellular Cer levels in human colon-carcinoma (HT29(rev)) cells by incubating the cells in the presence of bacterial sphingomyelinase (bSMase) or, alternatively, in the presence of C2-Cer, a short-chain

  6. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev ...

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Material Trends ( From M.Imada, A. Fujimori, and Y. Tokura, Rev. Mod. Phys. 70, 1039 (1998) ). Differences due to changes in cation radius causing bending of Mn-O-Mn bonds. Extreme sensitivity to small changes.

  7. 48 CFR 53.301-18 - SF 18 (Rev. 6/95), Request for Quotations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false SF 18 (Rev. 6/95), Request for Quotations. 53.301-18 Section 53.301-18 Federal Acquisition Regulations System FEDERAL ACQUISITION... for Quotations. EC01MY91.002 [60 FR 34763, July 3, 1995] ...

  8. Determining the REV for Fracture Rock Mass Based on Seepage Theory

    Directory of Open Access Journals (Sweden)

    Lili Zhang

    2017-01-01

    Full Text Available Seepage problems of the fractured rock mass have always been a heated topic within hydrogeology and engineering geology. The equivalent porous medium model method is the main method in the study of the seepage of the fractured rock mass and its engineering application. The key to the method is to determine a representative elementary volume (REV. The FractureToKarst software, that is, discrete element software, is a main analysis tool in this paper and developed by a number of authors. According to the standard of rock classification established by ISRM, this paper aims to discuss the existence and the size of REV of fractured rock masses with medium tractility and provide a general method to determine the existence of REV. It can be gleaned from the study that the existence condition of fractured rock mass with medium tractility features average fracture spacing smaller than 0.6 m. If average fracture spacing is larger than 0.6 m, there is no existence of REV. The rationality of the model is verified by a case study. The present research provides a method for the simulation of seepage field in fissured rocks.

  9. Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

    Science.gov (United States)

    Sail, Vibhavari; Rizzo, Alessandro A; Chatterjee, Nimrat; Dash, Radha C; Ozen, Zuleyha; Walker, Graham C; Korzhnev, Dmitry M; Hadden, M Kyle

    2017-07-21

    Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anticancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. The TLS DNA polymerase Rev1 serves as an integral scaffolding protein that mediates the assembly of the active multiprotein TLS complexes. Protein-protein interactions (PPIs) between the C-terminal domain of Rev1 (Rev1-CT) and the Rev1-interacting region (RIR) of other TLS DNA polymerases play an essential role in regulating TLS activity. To probe whether disrupting the Rev1-CT/RIR PPI is a valid approach for developing a new class of targeted anticancer agents, we designed a fluorescence polarization-based assay that was utilized in a pilot screen for small molecule inhibitors of this PPI. Two small molecule scaffolds that disrupt this interaction were identified, and secondary validation assays confirmed that compound 5 binds to Rev1-CT at the RIR interface. Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.

  10. Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1.

    Science.gov (United States)

    Noutsios, Georgios T; Papi, Rigini M; Ekateriniadou, Loukia V; Minas, Anastasios; Kyriakidis, Dimitrios A

    2012-03-01

    In the present study forty-four Greek endemic strains of Br. melitensis and three reference strains were genotyped by Multi locus Variable Number Tandem Repeat (ML-VNTR) analysis based on an eight-base pair tandem repeat sequence that was revealed in eight loci of Br. melitensis genome. The forty-four strains were discriminated from the vaccine strain Rev-1 by Restriction Fragment Length Polymorphism (RFLP) and Denaturant Gradient Gel Electrophoresis (DGGE). The ML-VNTR analysis revealed that endemic, reference and vaccine strains are genetically closely related, while most of the loci tested (1, 2, 4, 5 and 7) are highly polymorphic with Hunter-Gaston Genetic Diversity Index (HGDI) values in the range of 0.939 to 0.775. Analysis of ML-VNTRs loci stability through in vitro passages proved that loci 1 and 5 are non stable. Therefore, vaccine strain can be discriminated from endemic strains by allele's clusters of loci 2, 4, 6 and 7. RFLP and DGGE were also employed to analyse omp2 gene and reveled different patterns among Rev-1 and endemic strains. In RFLP, Rev-1 revealed three fragments (282, 238 and 44 bp), while endemic strains two fragments (238 and 44 bp). As for DGGE, the electrophoretic mobility of Rev-1 is different from the endemic strains due to heterologous binding of DNA chains of omp2a and omp2b gene. Overall, our data show clearly that it is feasible to genotype endemic strains of Br. melitensis and differentiate them from vaccine strain Rev-1 with ML-VNTR, RFLP and DGGE techniques. These tools can be used for conventional investigations in brucellosis outbreaks.

  11. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2004-05-15

    Elsam and Eltra built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm off the Danish west coast. The wind farm is sited 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine was erected in May 2002 and the last wind turbine tower of a total of 80 was in place by August 2002. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production by December 2002. The expected impact of the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind turbine towers and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horns Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site-specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrate was conducted in March 2003 and in September 2003. This report describes the first year results of surveys on hard substrate after the completion of the offshore wind farm at Horns Rev. (au)

  12. Offshore wind farms in the local community - a survey at Horns Rev wind farm. Background report; Havvindmoeller i lokalomraedet - en undersoegelse ved Horns Rev havmoellepark. Baggrundsrapport

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-07-15

    This report is part of a socio-economic project about offshore wind farms' influence on the local community. The project is part of the monitoring programme in connection with the establishment of the offshore wind farms at Horns Rev and Nysted. The socio-economic project consists of a sociological and an environment-economic project. This report is part of the sociological project which has the purpose of identifying attitudes towards the wind farm before and after the erection with a view to identify possible changes in opinions and reasons for these changes. (BA)

  13. MicroRNA-340 inhibits the proliferation and promotes the apoptosis of colon cancer cells by modulating REV3L

    Science.gov (United States)

    Arivazhagan, Roshini; Lee, Jaesuk; Bayarsaikhan, Delger; Kwak, Peter; Son, Myeongjoo; Byun, Kyunghee; Salekdeh, Ghasem Hosseini; Lee, Bonghee

    2018-01-01

    DNA Directed Polymerase Zeta Catalytic Subunit (REV3L) has recently emerged as an important oncogene. Although the expressions of REV3L are similar in normal and cancer cells, several mutations in REV3L have been shown to play important roles in cancer. These mutations cause proteins misfolding and mislocalization, which in turn alters their interactions and biological functions. miRNAs play important regulatory roles during the progression and metastasis of several human cancers. This study was undertaken to determine how changes in the location and interactions of REV3L regulate colon cancer progression. REV3L protein mislocalization confirmed from the immunostaining results and the known interactions of REV3L was found to be broken as seen from the PLA assay results. The mislocalized REV3L might interact with new proteins partners in the cytoplasm which in turn may play role in regulating colon cancer progression. hsa-miR-340 (miR-340), a microRNA down-regulated in colon cancer, was used to bind to and downregulate REV3L, and found to control the proliferation and induce the apoptosis of colon cancer cells (HCT-116 and DLD-1) via the MAPK pathway. Furthermore, this down-regulation of REV3L also diminished colon cancer cell migration, and down-regulated MMP-2 and MMP-9. Combined treatment of colon cancer cells with miR-340 and 5-FU enhanced the inhibitory effects of 5-FU. In addition, in vivo experiments conducted on nude mice revealed tumor sizes were smaller in a HCT-116-miR-340 injected group than in a HCT-116-pCMV injected group. Our findings suggest mutations in REV3L causes protein mislocalization to the cytoplasm, breaking its interaction and is believed to form new protein interactions in cytoplasm contributing to colon cancer progression. Accordingly, microRNA-340 appears to be a good candidate for colon cancer therapy. PMID:29435169

  14. Identification of Brucella melitensis Rev.1 vaccine-strain genetic markers: Towards understanding the molecular mechanism behind virulence attenuation.

    Science.gov (United States)

    Issa, Mohammad Nouh; Ashhab, Yaqoub

    2016-09-22

    Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard. The comparative analyses revealed 32 genetic alterations (30 SNPs, 1 single-bp insertion and 1 single-bp deletion) that are exclusively present in the Rev.1 genome. In silico analyses showed that 9 out of the 17 non-synonymous mutations are deleterious. Three ABC transporters are among the disrupted genes that can be linked to virulence attenuation. Out of the 32 mutations, 11 Rev.1 specific markers were selected to test their potential to discriminate Rev.1 using a bi-directional allele-specific PCR assay. Six markers were able to distinguish between Rev.1 and a set of control strains. We succeeded in identifying a panel of 32 genome-specific markers of the B. melitensis Rev.1 vaccine strain. Extensive in silico analysis showed that a considerable number of these mutations could severely affect the function of the associated genes. In addition, some of the discovered markers were able to discriminate Rev.1 strain from a group of control strains using practical PCR tests that can be applied in resource-limited settings. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Administrative Cicular No. 31 (Rev. 2) - International indemnity and non-resident allowance

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 31 (Rev. 2) entitled "International indemnity and non-resident allowance", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 23 June 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208547.   This revised circular cancels and replaces Administrative Circular No. 31 (Rev. 1) also entitled "International indemnity and non-resident allowance" of October 2007. The main changes reflect the decision taken in the framework of the five-yearly review to extend eligibility for international indemnity to all staff members, as well to introduce a distinction between current staff members and those recruited as from 1st September 2016. For the latter, the international indemnity will be calculated as a percentage of the minimum salary of the grade into which they are recruited; the amount granted to the former will not change, and is now expressed ...

  16. Administrative Circular No. 11 (Rev. 3) - Categories of members of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 11 (Rev. 3) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 3 July 2014 and entering into force on 1 September 2014, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel” of January 2013. The circular was revised in order to include a minor adjustment of the determination of required period of break in the payment of subsistence allowance to certain categories of associated members of the personnel (taking account of possible technical means of control). Furthermore, the possibility of traineeships of long duration was restricted to cases in which the traineeship is awarded pursuant to an agreement between CERN and a...

  17. Administrative Circular No. 13 (Rev. 3) - Guarantees for representatives of the personnel

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 13 (Rev. 3) entitled “Guarantees for representatives of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 5 December 2013 and entering into force on 1 January 2014, is available on the intranet site of the Human Resources Department (see here).   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 13 (Rev. 2) entitled “Guarantees for members of the personnel holding representative office” of November 1992. The circular was revised in order to adapt the time given to the representatives of the personnel to perform their elective mandate and to ensure more transparency in their activities, by indicating, inter alia, the percentage of time worked in the framework of their mandate, as well as the training, activities and ensuing results. Department Head Office HR Department

  18. Administrative circular n°23 (Rev. 3) – Special working hours

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 23 (Rev. 3) entitled “Special working hours”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to staff members and fellows. It cancels and replaces Administrative Circular No. 23 (Rev. 2) entitled “Special working hours” of December 2008. Paragraph 6 a) of Annex II of this circular was revised following the modification of Article III 1.04 of the Staff Regulations approved by Council on 14 December 2012. The modification serves to adapt the minimum rest time to the fact that, in case of rapidly alternating shifts, a maximum of seven consecutive shifts may be performed. Department Head Office HR Department

  19. Administrative circular n°11 (REV. 2) – Categories of members of the personnel

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 11 (Rev. 2) entitled “Categories of members of the personnel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 May 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department. This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 11 (Rev. 1) entitled “Categories of members of the personnel” of January 1997 as regards all contracts of members of the personnel issued on or after 1 January 2013. The circular was revised in order to take into account developments since the last revision of the categories of personnel in 1997 as well as the needs of the Organization and collaborating institutes. In particular, it introduces a new system for distinguishing categories of associated members of the personnel, namely with regard to the purpo...

  20. Administrative circular No. 20 (Rev. 2) – Use of private vehicules for journeys on official duty

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circular No. 20 (Rev. 2) entitled "Use of private vehicles for journeys on official duty", adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 January 2011, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 20 (Rev. 1) entitled "Use of private vehicles on official duty" of April 1993. This new version introduces, in particular, the payment of a kilometer allowance in case of emergency during standby duty or when on call and a simplified calculation of the allowance for journeys between sites. This circular also clarifies the type of permitted private vehicles. Department Head Office  

  1. Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

    Directory of Open Access Journals (Sweden)

    Dudley Jaquelin P

    2009-02-01

    Full Text Available Abstract Background Mouse mammary tumor virus (MMTV encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells. We have shown that Rem is expressed from a doubly spliced RNA, typical of complex retroviruses. Several recent reports indicate that MMTV can infect human cells, suggesting that MMTV might interact with human retroviruses, such as human immunodeficiency virus (HIV, human T-cell leukemia virus (HTLV, and human endogenous retrovirus type K (HERV-K. In this report, we test whether the export/regulatory proteins of human complex retroviruses will increase expression from vectors containing the Rem-responsive element (RmRE. Results MMTV Rem, HIV Rev, and HTLV Rex proteins, but not HERV-K Rec, enhanced expression from an MMTV-based reporter plasmid in human T cells, and this activity was dependent on the RmRE. No RmRE-dependent reporter gene expression was detectable using Rev, Rex, or Rec in HC11 mouse mammary cells. Cell fractionation and RNA quantitation experiments suggested that the regulatory proteins did not affect RNA stability or nuclear export in the MMTV reporter system. Rem had no demonstrable activity on export elements from HIV, HTLV, or HERV-K. Similar to the Rem-specific activity in rodent cells, the RmRE-dependent functions of Rem, Rev, or Rex in human cells were inhibited by a dominant-negative truncated nucleoporin that acts in the Crm1 pathway of RNA and protein export. Conclusion These data argue that many retroviral regulatory proteins recognize similar complex RNA structures, which may depend on the presence of cell-type specific proteins. Retroviral protein activity on the RmRE appears to affect a post-export function of the reporter RNA. Our results provide additional evidence that MMTV is a complex retrovirus with the potential for viral interactions in human cells.

  2. Effects on birds of an offshore wind park at Horns Rev: Environmental impact assessment

    Energy Technology Data Exchange (ETDEWEB)

    Noer, H.; Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [DMU, Dept. of Coastal Zone Ecology (Denmark)

    2000-07-01

    This report presents the technical background to the ornithological environmental impact assessment for the construction of an offshore windpark at Horns Rev, 14 km west-south-west of Blaevandshuk, Denmark. Construction of the park is planned to commence in 2001. The park will consist of c. 80 wind turbines, each of at least 1.8 MW, and cover an area of 27.5 km{sup 2} (including the 200 m exclusion zone around the park). (au)

  3. Determination of Geometrical REVs Based on Volumetric Fracture Intensity and Statistical Tests

    Directory of Open Access Journals (Sweden)

    Ying Liu

    2018-05-01

    Full Text Available This paper presents a method to estimate a representative element volume (REV of a fractured rock mass based on the volumetric fracture intensity P32 and statistical tests. A 150 m × 80 m × 50 m 3D fracture network model was generated based on field data collected at the Maji dam site by using the rectangular window sampling method. The volumetric fracture intensity P32 of each cube was calculated by varying the cube location in the generated 3D fracture network model and varying the cube side length from 1 to 20 m, and the distribution of the P32 values was described. The size effect and spatial effect of the fractured rock mass were studied; the P32 values from the same cube sizes and different locations were significantly different, and the fluctuation in P32 values clearly decreases as the cube side length increases. In this paper, a new method that comprehensively considers the anisotropy of rock masses, simplicity of calculation and differences between different methods was proposed to estimate the geometrical REV size. The geometrical REV size of the fractured rock mass was determined based on the volumetric fracture intensity P32 and two statistical test methods, namely, the likelihood ratio test and the Wald–Wolfowitz runs test. The results of the two statistical tests were substantially different; critical cube sizes of 13 m and 12 m were estimated by the Wald–Wolfowitz runs test and the likelihood ratio test, respectively. Because the different test methods emphasize different considerations and impact factors, considering a result that these two tests accept, the larger cube size, 13 m, was selected as the geometrical REV size of the fractured rock mass at the Maji dam site in China.

  4. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  5. Hard bottom substrate monitoring Horns Rev offshore wind farm. Annual status report. 2004

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B; Pedersen, John

    2005-05-15

    Elsam and Eltra have built the offshore demonstration wind farm at Horns Rev in the North Sea. Elsam is the owner and is responsible for the operation of the wind farm. Eltra is responsible for the connection of the wind farm to the national onshore grid. In the summer months of 2002, Elsam constructed the world's largest offshore wind farm at the Danish west coast. The wind farm is located 14-20 km into the North Sea, west of Blaevands Huk. The first wind turbine foundation was in place in March 2002 and the last mono-pile was in place in August 2002 for a total of 80. The construction work was completed with the last connecting cables sluiced down in September 2002. All the wind turbines were in production in December 2002. The expected impact from the wind farm will primarily be an alternation of habitats due to the introduction of hard bottom substrates as wind mono-piles and scour protections. A continuous development in the epifouling communities will be expected together with an introduction of new or alien species in the area. The indigenous benthic community in the area of Horn Rev can be characterised by infauna species belonging to the Goniadella-Spisula community. This community is typical of sandbanks in the North Sea area, although communities in such areas are very variable and site specific. Character species used as indicators for environmental changes in the Horns Rev area are the bristle worms Goniadella bobretzkii, Ophelia borealis, Psione remota and Orbinia sertulata and the mussels Goodallia triangularis and Spisula solida. In connection with the implementation of the monitoring programme concerning the ecological impact of the introduction of hard substrate related to the Horns Rev Wind Farm, surveys on hard bottom substrates were initialised in March 2003 with monitoring conducted in September 2003 and March and September 2004. This report describes the results from surveys on hard substrates in 2004. (au)

  6. Losers, Food, and Sex. Clerical Masculinity in the BBC Sitcom Rev.

    Directory of Open Access Journals (Sweden)

    Alexander Ornella

    2016-11-01

    Full Text Available Clerical masculinities, much like their lay/secular counterparts, often appear unchang¬ing because they are the products of naturalization processes. Clerical masculinities, however, are far from stable, for they live and breathe the dynamics of both their socio-religious context and their secular “others”. The BBC sitcom Rev. (BBC2, UK 2010–2014 is a refreshing take on the everyday life and problems of a vicar in the Church of England trying to avoid stereotypes that often come with clerical roles. Rev. (2010–2014 can be interpreted as an attempt to explore the negotiation processes of masculinity within an institution that is involved in the “production” of religion and gender roles. It shows that being a man in an institutional setting is as much a perfor¬mance as it is a more or less successful negotiation of other people’s expectations and one’s own worldview. In particular, the main male clerical characters in Rev. (2010– 2014 inhabit a position of power but all have their flaws. They can best be understood as losers whose clash with masculine systems renders them more human.

  7. Guidance and considerations for implementation of INFCIRC/225/Rev.3, the physical protection of nuclear material

    International Nuclear Information System (INIS)

    1997-09-01

    The Physical Protection of Nuclear Material, INFCIRC/225/Rev.3, provides recommendations for the physical protection of nuclear material against theft in use, storage and transport, whether national or international and whether peaceful or military, and contains provisions relating to the sabotage of nuclear material or facilities. The recommendations contained in INFCIRC/225/Rev.3 detail the elements that should be included in a State's system of physical protection. It also recognizes the adverse health and safety consequences arising from the theft of nuclear material and the sabotage of nuclear material or facilities. Most industrial and developing countries use these recommendations to some extent in the establishment and operation of their physical protection systems. Although INFCIRC/225/Rev.3 provides recommendations for protecting materials and facilities from theft or sabotage, it does not provide in-depth details for these recommendations. In June 1996, the IAEA convened a consultants meeting to consider this matter. This report is the result of continuing discussions and drafts over a period of nine months. The intent of this guidance is to provide a broader basis for relevant State organizations to prescribe appropriate requirements for the use of nuclear materials which are compatible with accepted international practice

  8. Status report of seabird surveys at Horns Rev, 2000-2001

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2002-01-01

    The present report presents the results of three bird surveys conducted in the Horns Rev area during the second half of 2001. Due to poor weather conditions in December 2001, the last survey was, however, performed on 7 January 2002. The surveys are part of the base-line investigations of birds performed in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. The results of the surveys during August 2001 - January 2002 are presented together with the results obtained during the period August 2000 - April 2001, and are also compared to results obtained during the period August 1999 - April 2000. Based on the distribution of the most abundant bird species recorded during 16 aerial surveys performed during August 1999 - January 2002, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, mainly occurring in the areas north and south of Horns Rev, and with low numbers on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common Scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although common scoter was found in relatively high numbers on the southeast slopes of the Horns Rev and within the wind farm area in the April 2001 survey. Common scoters occurred in very high numbers in January 2002. This was probably related to increased immigration of birds from the inner Danish waters during a cold period in late December 2001. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affect less than 1% of the various species, except divers where 1.58% will be

  9. DC Brushless Motor Control Design and Preliminary Testing for Independent 4-Wheel Drive Rev-11 Robotic Platform

    Directory of Open Access Journals (Sweden)

    Roni Permana Saputra

    2012-03-01

    Full Text Available This paper discusses the design of control system for brushless DC motor using microcontroller ATMega 16 that will be applied to an independent 4-wheel drive Mobile Robot LIPI version 2 (REV-11. The control system consists of two parts which are brushless DC motor control module and supervisory control module that coordinates the desired command to the motor control module. To control the REV-11 platform, supervisory control transmit the reference data of speed and direction of motor to control the speed and direction of each actuator on the platform REV-11. From the test results it is concluded that the designed control system work properly to coordinate and control the speed and direction of motion of the actuator motor REV-11 platform. 

  10. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  11. Horns Rev offshore wind farm. Environmental impact assessment of sea bottom and marine biology

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B

    2000-03-15

    An Environmental Impact Assessment (EIA) of a planned 150 MW offshore wind farm at Horns Rev has been carried out for the marine biology and sea bottom in the area, and includes vegetation and benthic fauna. The study forms part of a total EIA of the planned offshore wind farm. This EIA study has been drawn up in accordance with the guidelines laid down by the Ministry of Environment and Energy in the publication, 'Guidelines for preparation of EIAstudies for offshore wind farms. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. The area designated for the wind farm lies directly south of Horns Rev and is dominated by sand with a median particle size of 0.3 mm. Along the edges, towards areas of greater depth, the particle size increases. There are areas of fine sand in the deepest area, and in isolated pockets within the proposed wind farm site. The sediment is characterised by a very low (<1%) organic matter content. On the basis of the expected impact from the establishment of the wind farm, it is not deemed necessary to carry out special programmes during the construction phase for monitoring of the environmental-biological conditions. A monitoring and control programme is recommended during the production phase in order to follow the copper concentration in bivalves, or alternatively to initiate recovery or elimination of the copper-laden waste. A control programme is recommended during the production phase in order to follow the establishment and succession of the fouling community on the wind turbine foundations and scour-protecting revetments. (BA)

  12. Bird numbers and distributions in the Horns Rev offshore wind farm area. Annual status report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Krag Petersen, I.

    2005-07-01

    This report presents data from four aerial surveys of birds in the Horns Rev wind farm area in 2004. Three surveys from the winter and spring of 2004 are thoroughly reported here. The fourth survey of 9 September 2004 is reported in general terms, but not included in presentations of distribution and effect analyses of the wind farm. Data from this survey will be thoroughly dealt with in a future report. Including the four surveys of 2004, a total of 29 surveys have been performed in that area since August 1999. (au)

  13. Pilot power based rate control in CDMA 2000 1x EV-DO Rev-A

    Institute of Scientific and Technical Information of China (English)

    LIU Xiao-feng; GU Jian; YANG Hong-wen

    2008-01-01

    This article proposes a new algorithm to improvethe rate control efficiency of enhanced reverse link mediumaccess control (RLMAC) in the code division multiple access(CDMA) lx EV-DO release A(Rev. A) system. The newalgorithm brings reverse access terminal (AT) pilot power tothe RLMAC rate control procedure and makes it easier for alow pilot power user to increase its data rate when the systemis slightly loaded and harder to decrease its date rate when thesystem is heavily loaded. Numerical results of system levelsimulations show that the new algorithm can bring highersystem throughput, lower AT transmission power, and lowersystem load.

  14. Simulaton of the Avedøreværket Unit 1 Cogeneration Plant with DNA

    DEFF Research Database (Denmark)

    Elmegaard, Brian; Houbak, Niels

    2003-01-01

    The simulator contest proposed for the ECOS 2003 conference has been solved using the DNA energy system simulator. The contest concerns the steam process of the Avedøreværket Unit 1 (AVV1) power plant. The plant is a 250 MWCHP plant with a maximum district heat production of 330 MJ/s. The plant has...... a net electric efficiency of 42% and a maximum energy utilization of 92%. In this paper it is demonstrated, that the DNA model of AVV1 can calculate the whole flow sheet balance at any load point, i.e., any possible combination of power production and district heat production. The paper also contains...

  15. A novel, mouse mammary tumor virus encoded protein with Rev-like properties

    International Nuclear Information System (INIS)

    Indik, Stanislav; Guenzburg, Walter H.; Salmons, Brian; Rouault, Francoise

    2005-01-01

    We have identified a novel, multiple spliced, subgenomic mRNA species in MMTV producing cells of different origin containing an open reading frame encoding a 39-kDa Rev-like protein, Rem (regulator of expression of MMTV). An EGFP-Rem fusion protein is shown to be predominantly in the nucleolus. Further leptomycin B inhibits the nuclear export of nonspliced MMTV transcripts, implicating Rem in nuclear export by the Crm1 pathway in MMTV. Rem is thus reminiscent of the Rec protein from the related endogenous human retrovirus, HERV-K

  16. Permeability computation on a REV with an immersed finite element method

    International Nuclear Information System (INIS)

    Laure, P.; Puaux, G.; Silva, L.; Vincent, M.

    2011-01-01

    An efficient method to compute permeability of fibrous media is presented. An immersed domain approach is used to represent the porous material at its microscopic scale and the flow motion is computed with a stabilized mixed finite element method. Therefore the Stokes equation is solved on the whole domain (including solid part) using a penalty method. The accuracy is controlled by refining the mesh around the solid-fluid interface defined by a level set function. Using homogenisation techniques, the permeability of a representative elementary volume (REV) is computed. The computed permeabilities of regular fibre packings are compared to classical analytical relations found in the bibliography.

  17. Fundamental study on REV based on crack tensor at the Mizunami Underground Research Laboratory

    International Nuclear Information System (INIS)

    Tanno, Takeo; Sato, Toshinori; Sanada, Hiroyuki; Hikima, Ryoichi; Kumasaka, Hiroo; Tada, Hiroyuki

    2013-01-01

    The crack tensor model which is a kind of equivalent continuum model has been studied in rock mechanical investigation in the MIU. The fractured rock mass is modeled as the elastic continuum model with this crack tensor. In this study, this crack tensor based on the geological observation in the MIU project was calculated, and Representative Elementary Volume (REV) in the ventilation shaft and -300 m access/research gallery was studied based on the relative error of this crack tensor. As a result, the convergence of the relative error was faster in the -300 m access/research gallery than in the ventilation shaft. (author)

  18. High amplitude phase resetting in rev-erbalpha/per1 double mutant mice.

    Directory of Open Access Journals (Sweden)

    Corinne Jud

    Full Text Available Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis. The rhythms these clocks generate persist even in the absence of environmental cues with a period of about 24 hours. To tick in time, they continuously synchronize themselves to the prevailing photoperiod by appropriate phase shifts. In this study, we disrupted two molecular components of the mammalian circadian oscillator, Rev-Erbalpha and Period1 (Per1. We found that mice lacking these genes displayed robust circadian rhythms with significantly shorter periods under constant darkness conditions. Strikingly, they showed high amplitude resetting in response to a brief light pulse at the end of their subjective night phase, which is rare in mammals. Surprisingly, Cry1, a clock component not inducible by light in mammals, became slightly inducible in these mice. Taken together, Rev-Erbalpha and Per1 may be part of a mechanism preventing drastic phase shifts in mammals.

  19. Validation of CATHENA MOD-3.5/Rev0 for single-phase water hammer

    International Nuclear Information System (INIS)

    Beuthe, T.G.

    2000-01-01

    This paper describes work performed to validate the system thermalhydraulics code CATHENA MOD-3.5c/Rev0 for single-phase water hammer. Simulations were performed and are compared quantitatively against numerical tests and experimental results from the Seven Sisters Water Hammer Facility to demonstrate CATHENA can predict the creation and propagation of pressure waves when valves are opened and closed. Simulations were also performed to show CATHENA can model the behaviour of reflected and transmitted pressure waves at area changes, dead ends, tanks, boundary conditions, and orifices in simple and more complex piping systems. The CATHENA results are shown to calculate pressure and wave propagation speeds to within 0.2% and 0.5% respectively for numerical tests and within 3.3% and 5% for experimental results respectively. These results are used to help validate CATHENA for use in single-phase water hammer analysis. They also provide assurance that the fundamental parameters needed to successfully model more complex forms of water hammer are accounted for in the MOD-3.5c/Rev0 version of CATHENA, and represent the first step in the process to validate the code for use in modelling two-phase water hammer and condensation-induced water hammer. (author)

  20. Technical reports retrieval system(rev. 1) in the field of nuclear energy

    International Nuclear Information System (INIS)

    Choi, S.D.; Lee, Y.K.; Yim, S.H.

    1983-01-01

    TRRS(rev. 1), on-line Technical Reports Retrieval System, a set of computer programs, was designed and developed to provide fast and efficient access to computer-based information files. This system was foucused upon its application to the retrival of technical reports collected in KAERI, and developed not only to meet the requirements of researchers sitting at terminal but to accomodate its sufficiently general logic to other computer systems. The retrival program language is FORTRAN IV Plus. The users can search the whole files using next eleven TRRS(rev. 1) commands, HELP, SEARCH, LOOK, COMBINE, EXPAND, SELECT, REVIEW, RESTART, TYPE, PRINT, and END. The special features of this system are as follows. First, the SEARCH command can process full and truncation (truncation mark is %), and can combine such truncated terms using Boolean operators, and (*), and and-not (.). Second, COMBINE command can combine set numbers with year(s), language(s) and a substring of titles. Third, after EXPAND command, either full or truncated term, SELECT command brings same result of SEARCH command. Finally, real time response is very short, real time response is very short, usually within a second or less. (Author)

  1. Benchmark test of JENDL-3T and -3T/Rev.1

    International Nuclear Information System (INIS)

    Takano, Hideki; Kaneko, Kunio.

    1989-10-01

    The fast reactor 70-group constant set JFS-3-J3T has been generated by using the JENDL-3T nuclear data. One-dimensional 21-benchmark cores and the ZPPR-9 core were analysed with the JFS-3-J3T set. The results obtained are summarized as follows: (1) The values of keff are underestimated by 0.6% for Pu-fueled cores and overestimated by 2% for U-fueled cores. (2) The central reaction rate ratio 239 σ f φ/ 235 σ f φ is in a good agreement with the experimental value, though 238 σ c φ/ 239 σ f φ and 238 σ f φ/ 235 σ f φ are overestimated. (3) Doppler and Na-void reactivities are in a good agreement with the measured data. (4) The prediction accuracy of radial reaction rate distributions are improved in the comparison of the results obtained with the JENDL-2 data. Furthermore, the benchmark test of JENDL-3T/Rev. 1 which was revised from JENDL-3T for several important nuclides has been again performed. It was shown that JENDL-3T/Rev. 1 would predict nuclear characteristics more satisfactorily than JENDL-3T. (author)

  2. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.

    Directory of Open Access Journals (Sweden)

    Keith I Pardee

    2009-02-01

    Full Text Available Heme is a ligand for the human nuclear receptors (NR REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO, and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD. A 1.9 A crystal structure of the REV-ERBbeta LBD, in complex with the oxidized Fe(III form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBbeta complex reveal that the Fe(II form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions.

  3. The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

    Science.gov (United States)

    Pardee, Keith I; Xu, Xiaohui; Reinking, Jeff; Schuetz, Anja; Dong, Aiping; Liu, Suya; Zhang, Rongguang; Tiefenbach, Jens; Lajoie, Gilles; Plotnikov, Alexander N; Botchkarev, Alexey; Krause, Henry M; Edwards, Aled

    2009-01-01

    Heme is a ligand for the human nuclear receptors (NR) REV-ERBα and REV-ERBβ, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, inflammation, and cancer. Here we show that transcription repression mediated by heme-bound REV-ERBs is reversed by the addition of nitric oxide (NO), and that the heme and NO effects are mediated by the C-terminal ligand-binding domain (LBD). A 1.9 Å crystal structure of the REV-ERBβ LBD, in complex with the oxidized Fe(III) form of heme, shows that heme binds in a prototypical NR ligand-binding pocket, where the heme iron is coordinately bound by histidine 568 and cysteine 384. Under reducing conditions, spectroscopic studies of the heme-REV-ERBβ complex reveal that the Fe(II) form of the LBD transitions between penta-coordinated and hexa-coordinated structural states, neither of which possess the Cys384 bond observed in the oxidized state. In addition, the Fe(II) LBD is also able to bind either NO or CO, revealing a total of at least six structural states of the protein. The binding of known co-repressors is shown to be highly dependent upon these various liganded states. REV-ERBs are thus highly dynamic receptors that are responsive not only to heme, but also to redox and gas. Taken together, these findings suggest new mechanisms for the systemic coordination of molecular clocks and metabolism. They also raise the possibility for gas-based therapies for the many disorders associated with REV-ERB biological functions. PMID:19243223

  4. REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.

    Science.gov (United States)

    Garaulet, Marta; Smith, Caren E; Gomez-Abellán, Purificación; Ordovás-Montañés, María; Lee, Yu-Chi; Parnell, Laurence D; Arnett, Donna K; Ordovás, José M

    2014-04-01

    Despite the solid connection between REV-ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations. Participants were 2214 subjects from Spanish Mediterranean (n = 1404) and North American (n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the "abdominally obese" group than in those of the "nonabdominally obese" group (p obesity than noncarriers, and the effect was of similar magnitude for both populations (OR ≈ 1.50). There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits (p obesity was also detected in the Mediterranean population. This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Administrative Circular No. 2 (Rev. 7) - Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Multimedia

    2015-01-01

    Administrative Circular No. 2 (Rev. 7), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion at the Standing Concertation Committee meeting held on 17 February 2015 is available via the following link: AC No. 2 (Rev.7).   This revised circular cancels and replaces Administrative Circular No. 2 (Rev. 6), entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" and dated January 2015. The circular was revised in order to implement the amendment to Article R II 1.17 of the Staff Regulations, which introduces the possibility of extending limited-duration (LD) contracts up to a maximum total duration of eight years from the previous duration of five years. The award of indefinite contracts will continue to be subject to the outcome of a competitive process. Department Head Of...

  6. Administrative Circular No. 30 (Rev. 3) - “Financial benefits on taking up appointment and on termination of contract”

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 30 (Rev. 3) entitled “Financial benefits on taking up appointment and on termination of contract”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 27 June 2013 and entering into force on 1 August 2013, is available on the intranet site of the Human Resources Department (see here).   Administrative Circular No. 30 (Rev. 3) is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 30 (Rev. 2/Corr.) entitled "Financial benefits on taking up appointment and on termination of contract” of September 2009. This circular was revised in order to implement the modifications introduced into the Staff Rules and Regulations in January 2013 relating to the introduction of the status of Associate Member States and new categories of associated members of the personnel. In particular, the notion of “Member State” in Annexe II (&a...

  7. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp These Circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover in particular lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you require any additional informa...

  8. Administrative Circulars Nos. 12 A and B (Rev. 1) – Education Fees

    CERN Multimedia

    HR Department

    2007-01-01

    Administrative Circulars Nos. 12 A and B (Rev. 1) – "Education Fees" are now available on the intranet site of the Human Resources Department: http://https://hr-docs.web.cern.ch/hr-docs/admincirc/admincirc_fr.asp These circulars cancel and replace Administrative Circular No.12 – "Education Grant" of April 1981. Copies will shortly be available in Departmental secretariats. Administrative Circular No. 12 A is applicable to staff members (except former "local staff"), fellows and paid associates, recruited before 1st January 2007. It may be noted that, at the initiative of the Human Resources Department, a number of important simplifications have been introduced. These cover, in particular, lump sum payments to compensate for accommodation, meals and journey expenses. Administrative Circular No. 12 B is applicable to staff members, fellows, scientific associates recruited as of 1st January 2007, as well as to former "local staff" recruited prior to this date. If you requi...

  9. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    International Nuclear Information System (INIS)

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

  10. Numerical Modelling of Large-Diameter Steel Piles at Horns Rev

    DEFF Research Database (Denmark)

    Augustesen, Anders Hust; Brødbæk, K. T.; Møller, M.

    2009-01-01

    Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used as founda......Today large-diameter monopiles are the most common foundation type used for large offshore wind farms. This paper aims to investigate the behaviour of monopiles under monotonic loading taking the interaction between the pile and the subsoil into account. Focus is paid to a monopile used...... as foundation for a wind turbine at Horns Rev located in the Danish sector of the North Sea. The outer diameter of the pile is 4 m and the subsoil at the location consists primarily of sand. The behaviour of the pile is investigated under realistic loading conditions by means of a traditional Winkler...

  11. Safeguards Summary Event List (SSEL), January 1, 1990--December 31, 1996, Vol. 2, Rev. 5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The Safeguards Summary Event List (SSEL), Vol. 2, Rev. 5, provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC) which occurred and were reported from January 1, 1990, through December 31, 1996. Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of Bomb-related, Intrusion, Missing and/or Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms, Radiological Sabotage, Nonradiological Sabotage, and Miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels.

  12. Numerical modelling of powder caking at REV scale by using DEM

    Science.gov (United States)

    Guessasma, Mohamed; Silva Tavares, Homayra; Afrassiabian, Zahra; Saleh, Khashayar

    2017-06-01

    This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM). In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV), the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation) in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength).

  13. Numerical modelling of powder caking at REV scale by using DEM

    Directory of Open Access Journals (Sweden)

    Guessasma Mohamed

    2017-01-01

    Full Text Available This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM. In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV, the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength.

  14. OPERATIONAL CIRCULAR No. 4 (REV. 1) – USE OF VEHICLES BELONGING TO OR RENTED BY CERN

    CERN Document Server

    2012-01-01

    Operational Circular No. 4 (Rev. 1) entitled “Use of vehicles belonging to or rented by CERN”, approved by the Director-general following discussion in the Standing Concertation Committee meeting of 15 February 2012, is available on the intranet site of the Human Resources Department: https://hr-docs.web.cern.ch/hr-docs/opcirc/opcirc.asp It cancels and replaces Operational Circular No. 4 entitled “Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN” of April 2003. This new version enables, in particular, to include CERN contractors and their personnel, to harmonize the structure of the circular with other circulars and to simplify the procedures by permitting electronics forms. Department Head Office HR Department

  15. Introduction Of Wavestar Wave Energy Converters At The Danish Offshore Wind Power Plant Horns Rev 2

    DEFF Research Database (Denmark)

    Marquis, L.; Kramer, Morten; Kringelum, J.

    is to be connected to a wind turbine at the DONG Energy owned wind power plant Horns Rev 2 placed off the western coast of Denmark. The plant delivers its energy production to a transformer station owned by Energinet.dk. Energinet.dk has the obligation to ensure that power is transmitted to the Danish consumers...... with this combination. This can increase the value of the produced power from future wind/wave plants. Further potential synergies of combining wind and wave energy in the same area include increased energy production from the available area and sharing of infrastructure costs as well as O&M facilities. In a future....... If Executed the project will be the first one in the world where wind and wave power are combined at full scale. The goal of the project is to evaluate the opportunities of combining wind and wave energy production on a commercial scale and to demonstrate the reduction of energy fluctuations...

  16. Hard bottom substate monitoring Horns Rev offshore wind farm 2004. Survey report no. 1

    Energy Technology Data Exchange (ETDEWEB)

    Frederiksen, Rune

    2004-05-15

    In connection with the implementation of the monitoring programme concerning the ecological implication of the effect of the introduction of hard substrate related to the Horns Rev Wind Farm, the third survey was carried out in the period 2431 March 2004. The survey covered collection of fauna and flora samples from the scour protection and at the wind turbine towers at six turbine sites. Video recordings were planned at different sites to provide documentation, but due to poor visibility the video recordings were postponed. On request from Elsam Engineering A/S video inspections on technical installations were made at turbine '84 and 95. This report covers a short description of the methodology, sampling activities and site description. (au)

  17. Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors

    International Nuclear Information System (INIS)

    Kiss, A.; Li, L.; Gettemeier, T.; Venkatesh, L.K.

    2003-01-01

    Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear cofactors. In yeast two-hybrid screens of a human lymph node derived cDNA expression library, we identified the human nucleoporin Nup98 as a highly specific and potent interactor of the Rev NES. Using an extensive panel of nuclear export positive and negative mutants of the functionally homologous NESs of the HIV-1 Rev, human T cell leukemia virus type 1 (HTLV-1) Rex, and equine infectious anemia virus (EIAV) Rev proteins, physiologically significant interaction of hNup98 with the various NESs was demonstrated. Missense mutations in the yeast nuclear export factor Crm1p that abrogated Rev NES interaction with the XXFG repeat-containing nucleoporin, Rab/hRIP, had minimal effects on the interaction of GLFG repeat-containing hNup98. Functional analysis of Nup98 domains required for nuclear localization demonstrated that the entire ORF was required for efficient incorporation into the nuclear envelope. A putative nuclear localization signal was identified downstream of the GLFG repeat region. Whereas overexpression of both full-length Nup98 and the amino-terminal GLFG repeat region, but not the unique carboxy-terminal region, induced significant suppression of HIV unspliced RNA export, lower levels of exogenous Nup98 expression resulted in a relatively modest increase in unspliced RNA export. These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection

  18. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity.

    Science.gov (United States)

    Boons, Eline; Li, Guangdi; Vanstreels, Els; Vercruysse, Thomas; Pannecouque, Christophe; Vandamme, Anne-Mieke; Daelemans, Dirk

    2014-12-01

    The HIV Rev protein mediates the transport of partially and unspliced HIV mRNA from the nucleus to the cytoplasm. Rev multimerizes on a secondary stem-loop structure present in the viral intron-containing mRNA species and recruits the cellular karyopherin CRM1 to export viral mRNAs from the nucleus to the cytoplasm. Previously we have identified a single-domain intrabody (Nb(190)), derived from a llama heavy-chain antibody, which efficiently inhibits Rev multimerization and suppresses the production of infectious virus. We recently mapped the epitope of this nanobody and demonstrated that Rev residues K20 and Y23 are crucial for interaction while residues V16, H53 and L60 are important to a lesser extent. Here, we generated cell lines stably expressing Nb(190) and assessed the capacity of these cell lines to suppress the replication of different HIV-1 subtypes. These cells stably expressing the single-domain antibody are protected from virus-induced cytopathogenic effect even in the context of high multiplicity of infection. In addition, the replication of different subtypes of group M and one strain of group O is significantly suppressed in these cell lines. Next, we analysed the natural variations of Rev amino acids in sequence samples from HIV-1 infected patients worldwide and assessed the effect of Nb(190) on the most prevalent polymorphisms occurring at the key epitope positions (K20 and Y23) in Rev. We found that Nb(190) was able to suppress the function of these Rev variants except for the K20N mutant, which was present in only 0.7% of HIV-1 sequence populations (n = 4632). Cells stably expressing the single-domain intrabody Nb(190) are protected against virus-induced cytopathogenic effect and display a selective survival advantage upon infection. In addition, Nb(190) suppresses the replication of a wide range of different HIV-1 subtypes. Large-scale sequence analysis reveals that the Nb(190) epitope positions in Rev are well conserved across major HIV-1

  19. Administrative circular No. 2 (Rev. 5) – Recruitment, appointment and possible developments regarding the contractual position of staff members

    CERN Document Server

    HR Department

    2011-01-01

    Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 1 September 2011, is available on the intranet site of the Human Resources Department: https://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 2 (Rev. 4) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2009. Department Head Office

  20. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

    Directory of Open Access Journals (Sweden)

    Wesselingh Steven L

    2007-07-01

    Full Text Available Abstract Background The Sydney blood bank cohort (SBBC of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1. Although the cohort members have experienced differing clinical courses and now comprise slow progressors (SP as well as long-term nonprogressors (LTNP, longitudinal analysis of nef/long-terminal repeat (LTR sequences demonstrated convergent nef/LTR sequence evolution in SBBC SP and LTNP. Thus, the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef/LTR. Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36. Results The ability of Rev derived from D36 and C64 to bind the Rev responsive element (RRE in RNA binding assays was reduced by approximately 90% compared to Rev derived from HIV-1NL4-3, C18 or C98. D36 Rev also had a 50–60% reduction in ability to express Rev-dependent reporter constructs in mammalian cells. In contrast, C64 Rev had only marginally decreased Rev function despite attenuated RRE binding. In D36 and C64, attenuated RRE binding was associated with rare amino acid changes at 3 highly conserved residues; Gln to Pro at position 74 immediately N-terminal to the Rev activation domain, and Val to Leu and Ser to Pro at positions 104 and 106 at the Rev C-terminus, respectively. In D36, reduced Rev function was mapped to an unusual 13 amino acid extension at the Rev C-terminus. Conclusion These findings provide new genetic and mechanistic insights important for Rev function, and suggest that Rev function, not Rev/RRE binding may be rate limiting for HIV-1 replication. In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members.

  1. Analysis of translesion DNA synthesis activity of the human REV1 protein, which is a key player in radiation-induced mutagenesis

    International Nuclear Information System (INIS)

    Masuda, Yuji; Kamiya, Kenji

    2003-01-01

    Ionizing radiation frequently causes oxidative DNA damage in cells. It has been suggested that functions of the REV1 gene are induction of mutations and prevention of cell death caused by ionizing radiation through the damage bypass DNA replication. The gene product possesses a deoxycytidyl transferase activity, which is required for translesion DNA synthesis of a variety of damaged bases and an abasic site. To elucidate molecular mechanisms of the mutagenesis and translesion DNA synthesis, it is important to characterize the enzymatic properties of the REV1 protein. Here, we describe a novel method for purifying the recombinant human REV1 protein and the anzymatic properties of the protein. We established an efficient system for induction of the recombinant human REV1 protein in Escherichia coli cells. The REV1 protein was purified to homogeneity using nickel-chelating sepharose, heparin sepharose and superdex 200 chromatography. When purified by this method, REV1 protein is free of endo-, exonuclease and DNA polymerase activities. The purified REV1 protein is suitable for enzymological studies, and we used this to biochemical characterization. The REV1 protein inserts dCMP opposite templates G, A, T, C and an abasic site and inserts dGMP and dTMP opposite template G. Kinetic analysis provided evidence for high efficiency for dCMP insertion opposite template G and an abasic site, suggesting that the REV1 protein play a role in translesion DNA synthesis of an abasic site. (author)

  2. OPERATIONAL CIRCULAR NO2 (REV. 1) - APRIL 1998 'CONDITIONS OF ACCESS TO THE FENCED PARTS OF THE CERN SITE'

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Subsidiary document 'Implementation Measures' (Rev. 2) - April 2001 The subsidiary document has been amended. Copies are available from Divisional Secretariats and at CERN card issue points. Note : Administrative and operational circulars, as well as the lists of those in force, are available for consultation on WWW : ADMINISTRATIVE CIRCULARS OPERATIONAL CIRCULARS

  3. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Science.gov (United States)

    2013-05-13

    ...] Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not Withdrawn From Sale... ophthalmic solution), 0.5%, was not withdrawn from sale for reasons of safety or effectiveness. This... ophthalmic solution, 0.5%, if all other legal and regulatory requirements are met. FOR FURTHER INFORMATION...

  4. Finanšu pārskata revīzijas process lielai sabiedrībai

    OpenAIRE

    Špoģe, Sarmīte

    2018-01-01

    Finanšu pārskata revīzijas process ir svarīgs temats, jo pirmreizēji revidētiem uzņēmumiem tiek atklātas būtiskas neatbilstības grāmatvedības uzskaitē, tās atbilstībai LR likumiem un normatīvajiem aktiem, kā arī finanšu pārskata sagatavošanā. Darba mērķis: apkopot un analizēt finanšu pārskata revīzijas procesu lielā sabiedrībā, noteikt revīzijas riskus, izstrādāt priekšlikumus revīzijas procesa uzlabošanai. Izvirzīto mērķu sasniegšanai autore pētīja un apkopoja informāciju par finanšu pārska...

  5. Upper Bound Radiation Dose Assessment for Military Personnel at McMurdo Station, Antarctica, between 1962 and 1979 (2REV)

    Science.gov (United States)

    2017-09-30

    N IC A L R EP O R T Defense Threat Reduction Agency 8725 John J. Kingman Road , MS-6201 Fort Belvoir, VA 22060-6201 STANDARD FORM 298 (Rev. 8/98...8725 John J. Kingman Road , Mail Stop 6201 Fort...Early Operation ..................................................................................... 5 2.2 Operations and Maintenance

  6. Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    DEFF Research Database (Denmark)

    Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth

    2017-01-01

    (ADP) ribose polymerase 1 (PARP1) activity, low endogenous NAD+, low expression of SIRT1 and PGC1α and low adenosine monophosphate (AMP)-activated kinase (AMPK) activity. We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via...... the PARP-NAD+-SIRT1-PGC1α axis....

  7. Reliability of Concentric, Eccentric and Isometric Knee Extension and Flexion when using the REV9000 Isokinetic Dynamometer

    DEFF Research Database (Denmark)

    de Carvalho Froufe Andrade, Alberto César Pereira; Caserotti, Paolo; de Carvalho, Carlos Manuel Pereira

    2013-01-01

    The aim of this study was to assess the reliability of isokinetic and ISO knee extensor and flexor muscle strength when using the REV9000 (Technogym) isokinetic dynamometer. Moreover, the reliability of several strength imbalance indices and bilateral ratios were also examined. Twenty-four physic...

  8. A Comprehensive Experiment for Molecular Biology: Determination of Single Nucleotide Polymorphism in Human REV3 Gene Using PCR-RFLP

    Science.gov (United States)

    Zhang, Xu; Shao, Meng; Gao, Lu; Zhao, Yuanyuan; Sun, Zixuan; Zhou, Liping; Yan, Yongmin; Shao, Qixiang; Xu, Wenrong; Qian, Hui

    2017-01-01

    Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of…

  9. The calculational VVER burnup Credit Benchmark No.3 results with the ENDF/B-VI rev.5 (1999)

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Gual, Maritza [Centro de Tecnologia Nuclear, La Habana (Cuba). E-mail: mrgual@ctn.isctn.edu.cu

    2000-07-01

    The purpose of this papers to present the results of CB3 phase of the VVER calculational benchmark with the recent evaluated nuclear data library ENDF/B-VI Rev.5 (1999). This results are compared with the obtained from the other participants in the calculations (Czech Republic, Finland, Hungary, Slovaquia, Spain and the United Kingdom). The phase (CB3) of the VVER calculation benchmark is similar to the Phase II-A of the OECD/NEA/INSC BUC Working Group benchmark for PWR. The cases without burnup profile (BP) were performed with the WIMS/D-4 code. The rest of the cases have been carried with DOTIII discrete ordinates code. The neutron library used was the ENDF/B-VI rev. 5 (1999). The WIMS/D-4 (69 groups) is used to collapse cross sections from the ENDF/B-VI Rev. 5 (1999) to 36 groups working library for 2-D calculations. This work also comprises the results of CB1 (obtained with ENDF/B-VI rev. 5 (1999), too) and CB3 for cases with Burnup of 30 MWd/TU and cooling time of 1 and 5 years and for case with Burnup of 40 MWd/TU and cooling time of 1 year. (author)

  10. Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal human tissue

    NARCIS (Netherlands)

    Parmentier, H. K.; van Wichen, D. F.; Meyling, F. H.; Goudsmit, J.; Schuurman, H. J.

    1992-01-01

    The expression of regulatory proteins tat, rev, and nef of human immunodeficiency virus type-1 (HIV-1) and tat of HIV-2 was studied in frozen sections of lymph nodes from HIV-1-infected individuals, and various tissues from uninfected persons. In HIV-1-positive lymph nodes, monoclonal antibodies to

  11. Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

    Science.gov (United States)

    Vincendeau, Michelle; Kramer, Susanne; Hadian, Kamyar; Rothenaigner, Ina; Bell, Jeanne; Hauck, Stefanie M; Bickel, Christian; Nagel, Daniel; Kremmer, Elisabeth; Werner, Thomas; Leib-Mösch, Christine; Brack-Werner, Ruth

    2010-10-23

    In human astrocytes, restriction of HIV replication involves inhibition of HIV Rev activity. We previously identified a Rev-interacting human protein fragment (16.4.1) that can reduce Rev activity. The 16.4.1 sequence is contained in a group of highly similar host cell proteins, which we call the Risp family. Here we investigate whether the Risp family is connected to HIV replication in astrocytes. Cell/tissue lysates were analyzed for Risp expression by western blot with various anti-Risp antibodies. The interaction of astrocytic Risp members with Rev was investigated by affinity chromatography. Astrocytes were transfected with expression plasmids containing cDNAs encoding full-length Risp or the isolated 16.4.1 region for Risp overexpression or with siRNAs designed for Risp knock-down. Rev activity was investigated with a Rev-reporter assay. RNA levels were quantified by real-time RT-PCR, HIV Gag levels by p24ELISA. Expression of the Risp family was demonstrated in human brain tissues and astrocytes. Astrocytes were shown to produce Risp family members that interact with Rev. Production of HIV Gag proteins and Rev-dependent RNAs in persistently infected astrocytes increased upon Risp knock-down and decreased upon Risp overexpression. Risp knock-down increased Rev activity and raised proportions of Rev proteins in the nucleus of astrocytes. Our results link the Risp family to restriction of HIV production and inhibition of Rev activity in astrocytes. We conclude that the Risp family represents a novel family of host factors that can control HIV replication and may be important for the containment of HIV infection in brain reservoirs.

  12. Study on the REV Size of Fractured Rock in the Non-Darcy Flow Based on the Dual-Porosity Model

    Directory of Open Access Journals (Sweden)

    Yuan Wang

    2018-01-01

    Full Text Available For the problem of whether the representative elementary volume (REV obtained in the Darcy flow is also applicable to the case of the non-Darcy flow, the study on the REV size within the non-Darcy flow is proposed tentatively. The concept of the REV in the non-Darcy flow is based on the definition of the REV. According to the determination of the REV in the Darcy flow, the intrinsic permeability k and non-Darcy coefficient β are used simultaneously for the determination of the REV in the non-Darcy flow. The pore pressure cohesive element (PPCE is developed with the subroutine in ABAQUS. Then the simulation method of the Darcy and non-Darcy flow in the fractured rock mass is built using the PPCE. The proposed plan is examined through the comparison with existing research results. It is validated that this technic is efficient and accurate in simulating the Darcy and non-Darcy flow in the fractured rock mass. Combined with fracture networks generated by Monte Carlo Simulation technique, the PPCE is applied to the study on the REV size. Both conditions of the Darcy and non-Darcy flow are simulated for comparison. The simulation results of this model show that the REV of the non-Darcy flow is inconsistent with the REV of the Darcy flow, and the REV of the non-Darcy flow is more significant than the REV of the Darcy flow. The intrinsic permeability k tensors obtained in the Darcy flow and the non-Darcy flow are basically the same.

  13. The effects of cynodon dactylon on the immune response of NMRI-MICE after challenge with REV1

    Directory of Open Access Journals (Sweden)

    Behrooz Ilkhanizadeh

    2016-10-01

    Full Text Available Cynodon dactylon is used in Iranian traditional medicine as a healing agent for reducing the complications of diabetes mellitus. We proposed that Cynodon dactylon may perform its effects through moderating humoral and cellular immune responses. We aimed to determine the possible effects of hydroalcholic extract of Cynodon dactylonon humoral and cellular immune responses following the Rev1 challenge in the mouse model. 20 NMRI male mice were randomly grouped in two equal groups and immunized with Rev1[0.1 ml Rev1+0.9 PBS[. Mice in the treatment group orally received 400 mg/kg hydroalcoholic extract of Cynodon dactylon every day from the beginning of the study for 2 weeks. Blood samples were obtained from the animals 5 days after the last injection. Moreover, 48 hr before bleeding time, Rev1[0.1 ml Rev1+0.9 PBS[was injected into the left hind foot pad of mice. The levels of anti-Rev1 antibody and the specific cellular immune responses were measured by microhemagglutination test and footpad thickness, respectively. Moreover, susceptibility of macrophages respiratory burst and proliferation of immune cells were measured in order withNitroblue tetrazolium[NBT] and Microculture Tetrazolium Assay [MTT]. The concentrations of IL-1, TNFα, Il-6, and IL-10 in the serum were determined using commercially available ELISA kits. We found a significant increase in anti-Rev1 antibody levels and simultaneously a significant decrease in the level of cellular immunity[DTH] in the treatment group compared to the control group. Lymphocyte proliferation index in splenocytes was significantly increased in the treatment group. However, the level of respiratory burst in phagocytic population of splenocytes dramatically decreased in the treatment group compared to the control. A significant decrease in IL-6, TNF-α , IL-1 and increaseIl-10 serum levels were also seen in the treatment group. Cynodon dactylon extract could have an anti-inflammatory effect through

  14. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    International Nuclear Information System (INIS)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-01

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  15. Infauna monitoring Horns Rev offshore wind farm. Annual state report 2004

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-15

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  16. Horns Rev offshore wind power farm. Environmental impact assessment on water quality

    International Nuclear Information System (INIS)

    Andersen, Per

    2000-05-01

    As part of an overall Environmental Impact Assessment (EIA) undertaken in connection with a planned 150 MW offshore wind farm at Horns Rev, an assessment was made of the effects the wind farm would have on the water quality in the area. This EIA study was drawn up in accordance with the guidelines laid down by the Danish Ministry of Environment and Energy in the publication 'Guidelines for the preparation of EIA studies for offshore wind farms'. Horns Rev is situated off Blaevands Huk, which is Denmark's most westerly point. It is a shallow reef with water depths between 2 and 9 metres and is primarily composed of sand, gravel and pebbles. Only local and minor changes are anticipated in connection with the currents, sediments and wave conditions during the production phase. These will occur in the immediate vicinity of the individual foundations. For these reasons, no changes are expected in the water quality. This also includes also the pelagic primary production and the occurrence of plankton in the area. Increased local copper contamination of phytoplankton and zooplankton may be expected during the production phase, as a result of the total annual discharge of 206 kg copper from the slip-rings in the wind turbines. The contamination will potentially result in a local reduction of the pelagic primary production and changes in the species composition of the plankton. The wind turbines will be sandblasted and painted once during their lifetime, as part of the routine maintenance. The sandblasting and painting will lead to a temporary spill of paint, paint waste and sand. The impacts on water quality and plankton production are unknown. It is recommended that factors such as the toxicity of the paint be investigated, and that spills and the impact of waste be reduced as much as possible. The water quality and the plankton in the wind farm area and along the cable line's passage to shore through the international protected area, will only be affected in a minor way

  17. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2004

    International Nuclear Information System (INIS)

    Bech, M.; Frederiksen, R.; Pedersen, John; Leonhard, S.B.

    2005-04-01

    A total of 40 species were identified from the surveys in the Horns Rev area in September 2004 while 42 species were identified in 2003 and 47 species in September 2001. The decline in the number of species occurred both inside the wind farm and reference areas, which indicates that the decline could be a combination of changes in sediment characteristics and natural variation rather than an effect from the establishment of the wind farm. More species were not associated with the hard substrate at the turbine sites in 2004 compared to 2003, while in 2001, more species were associated with fine-grained sand. The median sediment grain size increased from 2001 to 2003 to 2004, which suggests that the velocity of the current increased, but modelling calculations on current speed predicted a 2% reduction in the wind farm area and up to a 15% reduction very close to the scour protection. These results agreed with the grain sizes found at the stations 5, 25 and 100 metres from the scour protection. At most stations, the medium grain size was 5 metres lower from the scour protection compared with the station 100 metres from the scour protection, which indicates that the velocity of the current was lower close to the scour protection. No significant impact on the infauna in the wind farm area was detectable concerning distance-related effects. Though general reductions in the population size of some of the character species in the surveyed areas might be related to changes in the sediment structure, the infauna community at Horns Rev showed no obvious sign of stress response as a consequence of possible impact from construction and operating activities. New species were observed in 2003 and 2004 and some of these might be a result of sediment characteristics, less predation or natural variation. The recording of other species might be a result of the introduction of hard bottom habitants in the wind farm area. The density of the most abundant bivalves and bristle worms was

  18. Infauna monitoring Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Bech, M.; Leonhars, S.B.; Pedersen, John

    2004-05-15

    ELSAM and ELTRA have established an offshore wind farm with an output of 160 MW in the waters of Horns Rev 1420 km off Blaevands Huk, which is the most westerly point of Denmark. The first phase of construction of the wind farm started in spring 2002. Before the construction activities took place, a baseline description of the benthos was conducted as a part of an environmental monitoring programme for the establishment of the Horns Rev Offshore Wind Farm. The baseline surveys for the present monitoring programme were conducted in the wind farm area on three occasions: spring 1999, spring 2001 and September 2001. In designated reference areas, surveys were conducted in spring 1999 and September 2001. The reference areas in 1999 and September 2001 were placed at two different geographical locations because the survey in September 2001 was planned to be a part of a fish monitoring programme. A comparison between the baseline study in spring 2001 and the baseline study in autumn 2001 clearly revealed that the biomass of most species increased considerably from spring to September. Despite the increase in biomass, the overall distribution of the species and their relative abundance did not change. In order to use the baseline data to investigate a possible impact after the construction of the wind farm, it was essential to arrange the monitoring programme either in spring or in September 2003, because the baseline studies were conducted in these periods. The monitoring programme was conducted in September 2003 after the wind farm had become operational, parallel with the survey on hard bottom substrates. The impacts of the wind farm on the benthic fauna (infauna) in the area were mainly expected to be due to the alteration of the local currents. As the changes in the currents are only minor, impacts on the water chemistry and on the benthic fauna resulting from hydrodynamic causes were expected to be limited or non-existent. The main objective of the present monitoring

  19. Bird numbers and distribution in the Horns Rev offshore wind farm area. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This report presents data from six aerial surveys of birds in the Horns Rev wind farm area in 2003. Including 16 surveys conducted before construction of the wind farm started and three during the construction phase, a total of 25 surveys have been performed in the area since August 1999. Up until August 2002 the study area was surveyed from 26 north-south oriented, parallel transect lines. After that time four short transects were added eastwards from the previously easternmost transect. From August 2002 slight adjustments to the transect lines in the wind farm area had to be made in order to avoid collision, as survey altitude was 76 m and wind turbines are 110 m to highest wing tip. The six surveys in 2003 were performed on 13 February, 16 March, 23 April, 5 September, 4 and 30 December. The operational phase of the wind farm commenced in 2002. Hence the six surveys from 2003 are all considered post-construction data sets. A preliminary evaluation of the potential impact of the wind turbines on bird distributions has been carried out by comparison of these data to those from the 16 pre-construction surveys. (au)

  20. Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production

    Science.gov (United States)

    Na, Hong; Huisman, Willem; Ellestad, Kristofor K.; Phillips, Tom R.; Power, Christopher

    2010-01-01

    Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analyses were performed in both an infectious FIV molecular clone and a FIV CAT-RRE reporter system. These studies disclosed that the stems within SLA (SA1, 2, 3, 4, and 5) of the RRE were critical but SA6 was not essential for FIV replication and CAT expression. These studies also revealed that the secondary structure rather than an antisense protein (ASP) mediates virus expression and replication in vitro. In addition, a single synonymous mutation within the FIV-RRE, SA3/45, reduced viral reverse transcriptase activity and p24 expression after transfection but in addition also showed a marked reduction in viral expression and production following infection. PMID:20570310

  1. Resposta imunitária à vacinação conjuntival com a estirpe Rev.1 de Brucella melitensis em ovinos e caprinos Serological response of sheep and goats to conjunctival Brucella melitensis Rev.1 vaccine

    Directory of Open Access Journals (Sweden)

    P. Poeta

    2003-04-01

    Full Text Available The live B. melitensis Rev.1 strain is considered the best vaccine available for the prophylaxis of brucellosis in small ruminants, especially when used at the standard dose by the conjunctival route. In the present study a 1´ 10(9 CFU dose for both sheep and goats conjunctivally vaccinated was tested to evaluate the duration of serological responses. Conjunctival vaccination with Rev. 1 performed in adult animals induced a rapid rise in serological titres as measured by Rose Bengal Plate Test (RBPT, Complement Fixation Test (CF and Modified Rose Bengal Plate Test (MRBPT. Titres then decreased and became negative in most animals by four months after vaccination (except MRBPT. The goats responded better to the vaccination than the sheep as one month after vaccination 100% of the goats revealed positive results to RB and RBM and 93.4% to FC test. The RBM was the one that detected more positive animals along the study.

  2. Administrative circulars No. 22A (rev. 1) – Award of additional periods of membership in the Pensions Fund for long-term shift work and No. 22B (rev. 1) – Compensation for long-term shift work hours

    CERN Multimedia

    HR Department

    2011-01-01

    Administrative Circulars No. 22A (Rev. 1) entitled "Award of additional periods of membership in the Pension Fund for long-term shift work" and No. 22B (Rev.1) entitled “Compensation for long-term shift work hours”, adopted following discussion in the Standing Concertation Committee meeting of 21 September 2010 and entering into force on 1 March 2011, are available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp They cancel and replace Administrative Circulars No. 22A and 22B entitled "Award of additional periods of membership in the Pension Fund to shift workers (Early Departure)” and “Duration and special compensation for shift work” of January 2000. This new version clarifies, in particular, the compensation of effective long-term shift work hours. Department Head Office  

  3. HRensembleHR. High resolution ensemble for Horns Rev. Final project report; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The wind farm output of an offshore-farm such as Horns Rev changes between nearly constant output to highly variable power output. A balance responsible will therefore benefit from knowing the variability of a wind farm in advance. Some understanding of the observed variability and the corresponding forecast error on offshore wind farms had been gathered in the past few years, while a large fraction (about 60%) of the error still lacked understanding and required further intense research. This was the outset at the beginning of the HREnsemble project. Results from the wave study, variability study, ocean coupling, findings from the sensitivity experiments, the iEnKF short-term forecast and finally the demonstration phase have given significant synergy. The most basic research result in the project is that the two empirical mode decomposition approaches, Hilbert-Huang and later the Ensemble Empirical Mode Decomposition (EEMD). Both approaches confirmed that significant variability exists in offshore conditions. It was found that the variability of the short time-scales (24 minutes) are either not explicitly visible in the grid-scale of the NWP models or in the best case significantly smoothed out in all of the tested model configurations. If we interpret 2/3 of the variability due to vertical waves not present in the mean flow and 1/3 of the variability due to meso-scale weather, then the model results and EEMD are consistent. We can however not verify this theory. At present we do not know if EEMD counts neither the events correct nor whether the ensemble forecast suppresses variability. The existence of variability above the time-scale related to friction between ocean waves and air can in fact explain some of the inconsistent results published in the literature and set a question mark behind the correctness of the calculation of friction in wave, ocean and weather modelling. (LN)

  4. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

    Science.gov (United States)

    Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

    2010-11-01

    Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

  5. ADMINISTRATIVE CIRCULAR No. 25 (REV. 3) - Special provisions for the fire and rescue service governing working and rest time

    CERN Multimedia

    2012-01-01

    Administrative Circular No. 25 (Rev. 3) entitled “Special provisions for the Fire and Rescue Service governing working and rest time”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 28 September 2012 and entering into force in October 2012, is available on the intranet site of the Human Resources Department: http://cern.ch/hr-docs/admincirc/admincirc.asp This Circular is applicable to staff members of the Fire and Rescue Service It cancels and replaces Administrative Circular No. 25 (Rev. 2) entitled “Shift work – Special provisions for the Fire and Rescue Service” of April 2003. This new version takes into account the new organisation of the Fire and Rescue Service, members of which will henceforth not exclusively perform their functions in the context of shift work, but also during reference working hours and during stand-by duty. Additionally, applicable limits regarding working and rest times an...

  6. Operational Circular No.2 (Rev. 2) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    2014-01-01

    Operational Circular No. 2 (Rev. 2) entitled “Conditions of access to the fenced parts of the CERN site” and its “implementation measures”, approved by the Director-General following discussion at the Standing Concertation Committee meeting on 20 May 2014 and entering into force on 1 September 2014, are available on the intranet site of the Human Resources Department (see here).   This circular is applicable to members of the personnel and other persons concerned. It cancels and replaces Operational Circular No. 2 (Rev. 1) entitled “Conditions of access to the fenced parts of the CERN site”, of April 1998. In particular, the revised circular provides for the possibility of mandating a person responsible for the proper implementation of the circular, specifies the rules relating to vehicles allowed on the site and the respective responsibilities of their owners, and relaxes certain administrative formalities in case of loss, theft or di...

  7. Operational Circular No. 2 (Rev. 3) - Conditions of access to the fenced parts of the CERN site

    CERN Multimedia

    HR Department

    2015-01-01

    Operational Circular No. 2 (Rev. 3) entitled "Conditions of access to the fenced parts of the CERN site", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 24 September 2015, is now available via this link.   This revised circular cancels and replaces Operational Circular No. 2 (Rev. 2) also entitled "Conditions of access to the fenced parts of the CERN site", of September 2014. The circular was revised predominantly in order to specify that access to the CERN site is granted to CERN Pension Fund beneficiaries only provided that they are actually in receipt of payments from the Fund; and to allow the Director-General to permit special types of vehicles on site, such as trailers. It also includes a certain number of text improvements and an updated version of the implementation measures, in particular with regard to vehicle identification, road traffic and parking.  

  8. Administrative circular n°3 (Rev. 2) – Home leave, travel to home station and assimilated leave and travel

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 3 (Rev. 2) entitled “Home leave, travel to the home station and assimilated leave and travel”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 11 October 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to employed members of the personnel. It cancels and replaces Administrative Circular No. 3 (Rev. 1) entitled “Travel to the home station and home leave” of June 2002. The circular was revised in order to take into account the new status of Associate Member State and the fact that henceforth, home stations may be situated on territory outside of Europe. It is proposed to introduce a new system of determination of the benefits (Travel expenses, travel time and distance indemnity) granted in the context of home leave and supplementary journeys to the home station.  For t...

  9. HRensembleHR. High resolution ensemble for Horns Rev. Final project report. Executive summary; Offshore wind power

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The development of offshore wind power results in more energy production per area unit and new requirements to the generation forecasts. Measurements from Horns Rev and ensemble forecasts were used to upgrade forecasting tools for the relevant periods and time scales. The most significant development is a new algorithm for short-term forecasts that combines any relevant online measurements by means of ensemble forecasts. (ln)

  10. Comment on "Total Negative Refraction in Real Crystals for Ballistic Electrons and Light" (Phys. Rev. Lett. 91, 157404 (2003))

    OpenAIRE

    Yau, H. -F.; Liu, J. -P.; Ke, B.; Kuo, C. -H.; Ye, Z.

    2003-01-01

    Recently, Zhang et al. (Phys. Rev. Lett. 91, 157404 (2003)) have demonstrated that an amphoteric refraction, i. e. both positive and negative refraction, may prevail at the interface of two uniaxial anisotropic crystals when their optical axes are in different directions. The authors subsequently made a correspondence between such a refraction with the negative refraction expected for Left Handed Materials (LHMs). Here we comment that the amphoteric refraction can be observed even with one un...

  11. Evaluación externa en la LOMCE. Reválidas, exclusión y competitividad

    Directory of Open Access Journals (Sweden)

    Ángel I. Pérez Gómez

    2014-01-01

    Full Text Available La evaluación de las competencias o cualidades humanas que cada aprendiz ha de desarrollar de manera singular para afrontar la complejidad de la era digital contemporánea es incompatible con las reválidas, test y pruebas externas estandarizadas, iguales para todos. Las cualidades más importantes del aprendizaje en la era digital —autodirección, iniciativa, creatividad, pensamiento crítico, solución de problemas y autoevaluación— son difícilmente evaluables mediante instrumentos baratos y masivos «de papel y lápiz», como los test estandarizados o las reválidas externas; requieren, por el contrario, herramientas y procesos más complejos, plurales y flexibles como la observación continua de los equipos docentes sobre el quehacer y los procesos y productos de los aprendices (Soto Gómez, 2014. La LOMCE,1 fiel exponente de la pedagogía conservadora del movimiento GERM,2 recupera las reválidas, pues apuesta por la estandarización de aprendizajes superficiales en lugar de potenciar el desarrollo singular de cada aprendiz hasta el máximo de sus posibilidades.

  12. An analysis of international situation concerning nuclear security. Focused on the revision to INFCIRC/225/Rev.5

    International Nuclear Information System (INIS)

    Inamura, Tomoaki; Tanabe, Tomoyuki

    2011-01-01

    Since the September 11 attacks in 2001, counterterrorism measures have become not just domestic issues but critical issues that need international cooperation. Various nuclear security measures are in place as part of international counterterrorism measures. This report looks at the trend of international nuclear security measures to get implications for Japan, focusing on INFCIRC/225/Rev.5, an international guideline for physical protection of nuclear materials and nuclear facilities drawn up by IAEA. The observations of this report are as follows: 1) While legally binding nuclear security measures such as multilateral treaties and United Nations Security Council Resolutions impose minimum requirements on individual countries, the approaches led by IAEA or individual countries or private associations aim at more detailed consideration or information sharing to further improve nuclear security. 2) INFCIRC/225/Rev.5 comprises new concepts such as risk-based physical protection and nuclear security culture, as well as extended range of threats such as insiders or stand-off attacks and broader scope of measures to response. Japan should consider incorporation of INFCIRC/225/Rev.5 to its national laws and regulations putting in mind that it may have heavy influence and that Japan pledged to role leadership about nuclear security to international society. (author)

  13. Safety and efficacy of reduced doses of Brucella melitensis strain Rev. 1 vaccine in pregnant Iranian fat-tailed ewes

    Directory of Open Access Journals (Sweden)

    Mohammad Ebrahimi

    2012-12-01

    Full Text Available Brucellosis is one of the most important zoonotic diseases and is a significant cause of abortion in animals. Brucella melitensis strain Rev. 1 is recommended as the most effective vaccine for small ruminants but the application of full doses in adult animals is restricted. This study was conducted to determine a proper reduced dose of vaccine which confers protection but which is not abortifacient in Iranian fat-tailed sheep. A total of 51 non-vaccinated pregnant ewes were divided into three main groups and several subgroups. Ewes in different groups were vaccinated at different stages of pregnancy and various subgroups were subcutaneously immunised with different quantities of the micro-organism (7.5 × 106, 106, 5 × 105. Ewes again became pregnant a year later and were challenged with the wild-type strain to evaluate the protection conferred. Results revealed that the proportion of vaccination-induced abortions was significantly higher in ewes immunised with 7.5 × 106 Rev. 1 organisms than in those which received 106 or 5 × 105 bacteria. While 80% of non-vaccinated ewes aborted after challenge, none of the vaccinated ewes aborted post-challenge. This study indicated that a reduced dose of Rev. 1 vaccine containing 106 or 5 × 105 live cells could be safely used to induce protection in Iranian fat-tailed sheep at various stages of pregnancy.

  14. hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Li Ziqiang; Zhang Hong; McManus, Terrence P.; McCormick, J. Justin; Lawrence, Christopher W.; Maher, Veronica M

    2002-12-29

    In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-blocking lesions, and for the majority of spontaneous mutations. To determine whether hREV3, the human homolog of yeast REV3, is similarly involved in error-prone translesion synthesis past UV photoproducts and other lesions that block DNA replication, an hREV3 antisense construct under the control of the TetP promoter was transfected into an infinite life span human fibroblast cell strain that expresses a high level of tTAk, the activator of that promoter. Three transfectant strains expressing high levels of hREV3 antisense RNA were identified and compared with their parental cell strain for sensitivity to the cytotoxic and mutagenic effects of UV. The three hREV3 antisense-expressing cell strains were not more sensitive than the parental strain to the cytotoxic effect of UV, but the frequency of mutants induced by UV in their HPRT gene was significantly reduced, i.e. to 14% that of the parent. Two of these hREV3 antisense-expressing cell strains were compared with the parental strain for sensitivity to ({+-})-7{beta},8{alpha}-dihydroxy-9{alpha},10{alpha}-epoxy-7,8,9,10-tetrahydro= benzo[a]pyrene (BPDE). They were not more sensitive than the parent strain to the cytotoxic effect of BPDE, but the frequency of mutants induced was significantly reduced, i.e. in one strain, to 17% that of the parent, and in the other, to 24%. DNA sequencing showed that the kinds of mutations induced by BPDE in the parental and the derivative strains did not differ and were similar to those found previously with finite life span human fibroblasts. The data strongly support the hypothesis that hRev3 plays a critical role in the induction of mutations by UV or BPDE. Because the level of hRev3 protein in human fibroblasts is below the level of antibody

  15. hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

    International Nuclear Information System (INIS)

    Li Ziqiang; Zhang Hong; McManus, Terrence P.; McCormick, J. Justin; Lawrence, Christopher W.; Maher, Veronica M.

    2002-01-01

    In S. cerevisiae, the REV3 gene, encoding the catalytic subunit of polymerase zeta, is involved in translesion synthesis and required for the production of mutations induced by ultraviolet radiation (UV) photoproducts and other DNA fork-blocking lesions, and for the majority of spontaneous mutations. To determine whether hREV3, the human homolog of yeast REV3, is similarly involved in error-prone translesion synthesis past UV photoproducts and other lesions that block DNA replication, an hREV3 antisense construct under the control of the TetP promoter was transfected into an infinite life span human fibroblast cell strain that expresses a high level of tTAk, the activator of that promoter. Three transfectant strains expressing high levels of hREV3 antisense RNA were identified and compared with their parental cell strain for sensitivity to the cytotoxic and mutagenic effects of UV. The three hREV3 antisense-expressing cell strains were not more sensitive than the parental strain to the cytotoxic effect of UV, but the frequency of mutants induced by UV in their HPRT gene was significantly reduced, i.e. to 14% that of the parent. Two of these hREV3 antisense-expressing cell strains were compared with the parental strain for sensitivity to (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). They were not more sensitive than the parent strain to the cytotoxic effect of BPDE, but the frequency of mutants induced was significantly reduced, i.e. in one strain, to 17% that of the parent, and in the other, to 24%. DNA sequencing showed that the kinds of mutations induced by BPDE in the parental and the derivative strains did not differ and were similar to those found previously with finite life span human fibroblasts. The data strongly support the hypothesis that hRev3 plays a critical role in the induction of mutations by UV or BPDE. Because the level of hRev3 protein in human fibroblasts is below the level of antibody detection, it was not

  16. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

    Energy Technology Data Exchange (ETDEWEB)

    Morioka, Norimitsu, E-mail: mnori@hiroshima-u.ac.jp; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

    2016-01-08

    Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

  17. Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

    International Nuclear Information System (INIS)

    Morioka, Norimitsu; Tomori, Mizuki; Zhang, Fang Fang; Saeki, Munenori; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro

    2016-01-01

    Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.

  18. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    International Nuclear Information System (INIS)

    2000-05-01

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licencee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  19. Evolution of ASTEC V1.2 rev.1 code for WWER-1000 reactors/SBO sequence

    International Nuclear Information System (INIS)

    Georgieva, J.; Stefanova, A.; Groudev, P.; Tusheva, P.; Kalchev, B.; Passalacqua, R.

    2006-01-01

    In this paper a comparison between calculations of severe accidents occurred from WWER-1000 with ASTEC code specified for an event of full unloading with relief valves stuck opened with no hydroaccumulators intervention is presented. The purpose of the analyses provided is to present the relationship between the improvements of the actual version (ASTEC Vl.2 rev. 1) and ASTEC V1.1 p2 like: code modifications, incoming data improvements. Such discrepancies are to be examined. Case by case suggestions for ASTEC improvements are to be provided

  20. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-15

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind

  1. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2001 - 31. December 2001

    International Nuclear Information System (INIS)

    2002-10-01

    As a result of the Danish Government's Energy Plan 21 a target of 5,500 MW wind power is to be erected in Denmark by 2030. 4,000 MW of these are to be placed offshore in special pointed areas with minimal impacts on the environment. In 1998 the Danish Ministry of Environment and Energy ordered two power companies, Elsam and Energi E2, to establish each a demonstration wind farm at one of the five pointed areas. The intention was to follow the environmental impacts from the wind farm and to evaluate the possibility of setting up about 1,500 MW in each area with as little impact on the environment as possible. In 1999 the two power companies were given approval to begin pre-studies of each of the two wind farms and the work on the site construction as well as the environmental impact assessment related hereto was initiated. The authorities made a number of requirements for the EIA surveys according to the EU-directive for preparation of EIA reports. In the summer of 2000 the EIA report with project description was submitted to the authorities and the project was approved in the spring of 2001. During the summer and autumn of 2001 orders were placed for the components for the wind farm, i.e. foundations, towers, wind turbines, cables etc. After having finalised the EIA, monitoring programmes of the wind farms were initiated on basis of the results of the surveys carried out during the EIA. This means that continuous surveys have been implemented for most of the environmental parameters from 1999 and till today. This annual status report for 2001 is to present the results from the annual environmental monitoring programme (the baseline studies) at Horns Rev, which form part of the monitoring programme set up for the Horns Rev project. To get a complete picture of the Danish monitoring programme for the national demonstration wind farm project it is necessary to see the report for Horns Rev and for Roedsand as a whole. The report comprises a description of the wind farm

  2. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    International Nuclear Information System (INIS)

    2002-05-01

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  3. Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBα/NCoR.

    Science.gov (United States)

    Westermaier, Yvonne; Ruiz-Carmona, Sergio; Theret, Isabelle; Perron-Sierra, Françoise; Poissonnet, Guillaume; Dacquet, Catherine; Boutin, Jean A; Ducrot, Pierre; Barril, Xavier

    2017-08-01

    The knowledge of the free energy of binding of small molecules to a macromolecular target is crucial in drug design as is the ability to predict the functional consequences of binding. We highlight how a molecular dynamics (MD)-based approach can be used to predict the free energy of small molecules, and to provide priorities for the synthesis and the validation via in vitro tests. Here, we study the dynamics and energetics of the nuclear receptor REV-ERBα with its co-repressor NCoR and 35 novel agonists. Our in silico approach combines molecular docking, molecular dynamics (MD), solvent-accessible surface area (SASA) and molecular mechanics poisson boltzmann surface area (MMPBSA) calculations. While docking yielded initial hints on the binding modes, their stability was assessed by MD. The SASA calculations revealed that the presence of the ligand led to a higher exposure of hydrophobic REV-ERB residues for NCoR recruitment. MMPBSA was very successful in ranking ligands by potency in a retrospective and prospective manner. Particularly, the prospective MMPBSA ranking-based validations for four compounds, three predicted to be active and one weakly active, were confirmed experimentally.

  4. REMINDER: Compliance with Operational Circular No. 2 (Rev. 1) on “Conditions of access to the fenced CERN site”

    CERN Multimedia

    2012-01-01

    The purpose of Operational Circular No. 2 (Rev. 1) is to contribute to the protection of people and property by defining the conditions of access to the Organization's fenced sites. The behaviours that cannot be tolerated under any circumstances are: use of CERN access cards by people, other than the cardholders themselves, in order to gain access to facilities without having attended the required safety course; speeding, particularly on Route Gregory and Route Weisskopf; driving in and out of the site on the wrong side of the road; parking on spaces set aside for the disabled; nuisance parking, especially in the proximity of the restaurants; dumping of wrecked vehicles. As the aforementioned instances of non-compliance can lead to dangerous situations, the Organization reserves the right to apply the penalties provided for under paragraph 26 of Operational Circular No. 2 (Rev. 1), namely to refuse access to the site to people and/or their vehicles deemed to be in infringement of the circu...

  5. A numerical-statistical approach to determining the representative elementary volume (REV of cement paste for measuring diffusivity

    Directory of Open Access Journals (Sweden)

    Zhang, M. Z.

    2010-12-01

    Full Text Available Concrete diffusivity is a function of its microstructure on many scales, ranging from nanometres to millimetres. Multi-scale techniques are therefore needed to model this parameter. Representative elementary volume (REV, in conjunction with the homogenization principle, is one of the most common multi-scale approaches. This study aimed to establish a procedure for establishing the REV required to determine cement paste diffusivity based on a three-step, numerical-statistical approach. First, several series of 3D cement paste microstructures were generated with HYMOSTRUC3D, a cement hydration and microstructure model, for different volumes of cement paste and w/c ratios ranging from 0.30 to 0.60. Second, the finite element method was used to simulate the diffusion of tritiated water through these microstructures. Effective cement paste diffusivity values for different REVs were obtained by applying Fick’s law. Finally, statistical analysis was used to find the fluctuation in effective diffusivity with cement paste volume, from which the REV was then determined. The conclusion drawn was that the REV for measuring diffusivity in cement paste is 100x100x100 μm3.

    La difusividad del hormigón depende de su microestructura a numerosas escalas, desde nanómetros hasta milímetros, por lo que se precisa de técnicas multiescala para representar este parámetro. Junto con el principio de homogeneización, uno de los métodos multiescala más habituales es el volumen elemental representativo (VER. El objeto de este estudio era establecer un procedimiento que permitiera determinar el VER necesario para calcular la difusividad de la pasta de cemento, basándose en un método numéricoestadístico que consta de tres etapas. Primero, se crearon varias series de microestructuras de pasta de cemento en 3D con HYMOSTRUC3D, un programa que permite crear un modelo de la hidratación y microestructura del cemento. Luego se empleó el método de

  6. The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles

    Directory of Open Access Journals (Sweden)

    Ma Hong

    2011-06-01

    Full Text Available Abstract Background The process of HIV-1 genomic RNA (gRNA encapsidation is governed by a number of viral encoded components, most notably the Gag protein and gRNA cis elements in the canonical packaging signal (ψ. Also implicated in encapsidation are cis determinants in the R, U5, and PBS (primer binding site from the 5' untranslated region (UTR. Although conventionally associated with nuclear export of HIV-1 RNA, there is a burgeoning role for the Rev/RRE in the encapsidation process. Pleiotropic effects exhibited by these cis and trans viral components may confound the ability to examine their independent, and combined, impact on encapsidation of RNA into HIV-1 viral particles in their innate viral context. We systematically reconstructed the HIV-1 packaging system in the context of a heterologous murine leukemia virus (MLV vector RNA to elucidate a mechanism in which the Rev/RRE system is central to achieving efficient and specific encapsidation into HIV-1 viral particles. Results We show for the first time that the Rev/RRE system can augment RNA encapsidation independent of all cis elements from the 5' UTR (R, U5, PBS, and ψ. Incorporation of all the 5' UTR cis elements did not enhance RNA encapsidation in the absence of the Rev/RRE system. In fact, we demonstrate that the Rev/RRE system is required for specific and efficient encapsidation commonly associated with the canonical packaging signal. The mechanism of Rev/RRE-mediated encapsidation is not a general phenomenon, since the combination of the Rev/RRE system and 5' UTR cis elements did not enhance encapsidation into MLV-derived viral particles. Lastly, we show that heterologous MLV RNAs conform to transduction properties commonly associated with HIV-1 viral particles, including in vivo transduction of non-dividing cells (i.e. mouse neurons; however, the cDNA forms are episomes predominantly in the 1-LTR circle form. Conclusions Premised on encapsidation of a heterologous RNA into

  7. Hydroacoustic registration of fish abundance of offshore wind farms. Horns Rev offshore wind farm. Annual report 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Hvidt, C.B.; Bruenner, L.; Reier Knudsen, F.

    2005-05-15

    Elsam Engineering AS has approved the implementation of a project concerning the registration of fish communities in Horns Rev Offshore Wind Farm with use of hydroacoustic methods. In a joint effort, Bio/consult as, Carl Bro as and SIMRAD AS have monitored the fish communities at Horns Rev Offshore Wind Farm using a new hydroacoustic methodology. The new hydroacoustic technique combines the use of scientific sonar acoustics with GPS to determine the density, diversity and location of fish. The objectives of this project were to test the possibility of using hydroacoustic techniques as alternative methods to traditional techniques to assess the fish assemblage inhabiting offshore wind farms and to investigate the possible effect from the wind farm and hard bottom substrates (turbine foundations) on fish abundance. The field study was carried out October 9-10, 2004 and consisted of four horizontal hydroacoustic survey transects each covering impact and reference areas. Transects were surveyed in order to achieve identical impact and reference transect pairs concerning environment, topography and time correspondence. The hydroacoustic equipment consisted of a SIMRAD EK60/EY60 echo sounder with a split-beam transducer (Simrad ES 120-4x10) mounted on a pan and tilt unit, a transceiver, a laptop extended with a GPS-receiver and additional large external hard discs. The raw data files from EK60 were converted to echogram files suitable for the post processing application, Sonar5-Pro. The Sonar5-Pro software makes it possible to filter out echo detections from the surface and the bottom, as well as perform cross filter detection. The validity of the results using the hydroacoustic method is high due to the cross filtering and single target tracking technique. From the hydroacoustic results, no or very little effect from the wind farm or from hard bottom substrates was found on the fish densities at Horns Rev Wind Farm at the time of the survey. The execution of the field

  8. LLNL Radiation Protection Program (RPP) Rev 9.2, Implementation of 10 CFR 835, 'Occupational Radiation Protection'

    Energy Technology Data Exchange (ETDEWEB)

    Shingleton, K. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-06-15

    The Department of Energy (DOE) originally issued Part 10 CFR 835, Occupational Radiation Protection, on January 1, 1994. This regulation, hereafter referred to as “the Rule”, required DOE contractors to develop and maintain a DOE-approved Radiation Protection Program (RPP); DOE approved the initial Lawrence Livermore National Laboratory (LLNL) RPP (Rev 2) on 6/29/95. DOE issued a revision to the Rule on December 4, 1998 and approved LLNL’s revised RPP (Rev 7.1) on 11/18/99. DOE issued a second Rule revision on June 8, 2007 (effective July 9, 2007) and on June 13, 2008 approved LLNL’s RPP (Rev 9.0) which contained plans and measures for coming into compliance with the 2007 Rule changes. DOE issued a correction to the Rule on April 21, 2009.

  9. Estimation of turbulence intensity using rotor effective wind speed in Lillgrund and Horns Rev-I offshore wind farms

    DEFF Research Database (Denmark)

    Gögmen, Tuhfe; Giebel, Gregor

    2016-01-01

    varies over the extent of the wind farm. This paper describes a method to estimate the TI at individual turbine locations by using the rotor effective wind speed calculated via high frequency turbine data. The method is applied to Lillgrund and Horns Rev-I offshore wind farms and the results are compared...... with TI derived from the meteorological mast, nacelle mounted anemometer on the turbines and estimation based on the standard deviation of power. The results show that the proposed TI estimation method is in the best agreement with the meteorological mast. Therefore, the rotor effective wind speed...... is shown to be applicable for the TI assessment in real-time wind farm calculations under different operational conditions. Furthermore, the TI in the wake is seen to follow the same trend with the estimated wake deficit which enables to quantify the turbulence in terms of the wake loss locally inside...

  10. Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

    International Nuclear Information System (INIS)

    2005-07-01

    In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

  11. Amchitka Mud Pit Sites 2006 Post-Closure Monitoring and Inspection Report, Amchitka Island, Alaska, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Patrick

    2006-09-01

    In 2001, the U.S. Department of Energy (DOE), National Nuclear Security Administration (NNSA/NSO) remediated six areas associated with Amchitka mud pit release sites located on Amchitka Island, Alaska. This included the construction of seven closure caps. To ensure the integrity and effectiveness of remedial action, the mud pit sites are to be inspected every five years as part of DOE's long-term monitoring and surveillance program. In August of 2006, the closure caps were inspected in accordance with the ''Post-Closure Monitoring and Inspection Plan for Amchitka Island Mud Pit Release Sites'' (Rev. 0, November 2005). This post-closure monitoring report provides the 2006 cap inspection results.

  12. Elsam. Offshore Wind Turbines. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2004 - 31. December 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-15

    In 2001, the former Ministry of the Environment and Energy granted Elsam A/S and Eltra A.m.b.A. approval to establish a wind farm capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk at the west coast of Jutland. According to the conditions of the approval, Elsam and Eltra were required to monitor the environmental effects of the wind farm by performing monitoring before, during and after construction of the wind farm. The environmental monitoring programme is financed through Public Service Obligation (PSO). Analogue to the Horns Rev wind farm another offshore demonstrational wind farm was established in the Baltic sea south of Lolland by Energi E2 the Nysted 165 MW offshore wind farm. To coordinate the environmental monitoring at the two demonstration wind farms at Nysted and Horns Rev within the framework of the approved budget, the Environmental Group of Danish Offshore Wind Farm Demonstration Projects was set up. The group consists of representatives from the Danish Forest and Nature Agency, the Danish Energy Authority, Elsam and Energi E2. The Environmental Group initiates, monitors and evaluates the environmental programmes continuously with respect to possible improvements and intensifications to ensure that the design of the individual programmes is optimal. After evaluation, the monitoring programmes are proposed by the Environmental Group and carried out after final approval by the Danish Energy Authority. The Environmental Group considers if there is reason to adjust the issues and priorities of the programmes based on previous experience or other inputs eg from the international expert panel, IAPEME (International Advisory Panel of Experts on Marine Ecology). IAPEME evaluates the environmental monitoring programmes and makes valuable suggestions and recommendations to the Environmental Group. The programmes have concentrated on the monitoring of possible impacts before, during and after construction to investigate and

  13. Visual and radar observations of birds in relation to collision risk at the Horns Rev offshore wind farm. Annual status report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Hounisen, J.P.; Clausager, I.; Krag Petersen, I.

    2004-07-01

    The aim of the project is to assess the collision risk between birds and wind turbines at the Horns Rev wind farm. In 2003 the studies focused on describing bird movements in relation to the wind farm and to identify the species-specific behavioural responses towards the wind turbines shown by migrating and staging species. The Horns Rev area lies in a region known to be important for substantial water bird migration as well as holding internationally important numbers of several wintering and staging water bird species. (au)

  14. 78 FR 11907 - Notice of Forthcoming Workshop To Discuss Revisions to NUREG/BR-0204, Rev. 2 “Instructions for...

    Science.gov (United States)

    2013-02-20

    ... radioactive waste disposal facilities if over-estimated. Additionally, the NRC staff received comments from... Performance Assessment Methodology for Low-Level Radioactive Waste Disposal Facilities'' (ADAMS Accession No..., Rev. 2 ``Instructions for Completing NRC's Uniform Low-Level Radioactive Waste Manifest.'' Information...

  15. Post-construction evaluation of bird abundances and distributions in the Horns Rev 2 offshore wind farm area, 2011 and 2012

    DEFF Research Database (Denmark)

    Petersen, Ib Krag; Nielsen, Rasmus Due; Mackenzie, Monique L.

    2014-01-01

    Optællinger af fugle fra fly efter linjetransekt-metoden blev anvendt til at beskrive fuglenes antal og udbredelse i undersøgelsesområdet. Ti optællinger før Horns Rev 2 mølleparkens opførelse blev sammenlignet med ti optællinger foretaget efter parkens etablering. Rumlig modellering blev anvendt...

  16. Evaluation of vaccination strategies against infection with feline immunodeficiency virus (FIV) based on recombinant viral vectors expressing FIV Rev and OrfA

    NARCIS (Netherlands)

    Huisman, W.; Schrauwen, E.J.A.; Tijhaar, E.; Süzer, Y.; Pas, S.D.; Amerongen, van G.; Sutter, G.; Rimmelzwaan, G.F.; Osterhaus, A.D.M.E.

    2008-01-01

    In recent years it has become clear that cell-mediated immunity is playing a role in the control of lentivirus infections. In particular, cytotoxic T lymphocyte responses have been associated with improved outcome of infection, especially those directed against the regulatory proteins like Rev and

  17. Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005)

    International Nuclear Information System (INIS)

    Seijas Portela, S.

    2010-01-01

    Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

  18. 75 FR 75486 - Maritime Security Directive 104-6 (Rev. 4); Guidelines for U.S. Vessels Operating in High Risk...

    Science.gov (United States)

    2010-12-03

    ... Directive 104-6 (Rev. 4); Guidelines for U.S. Vessels Operating in High Risk Waters AGENCY: Coast Guard, DHS... Maritime Transportation Security Act (MTSA) on international voyages through or in designated high risk... MARSEC Directives are available at your local Captain of the Port (COTP) office. Phone numbers and...

  19. 76 FR 2402 - Maritime Security Directive 104-6 (Rev 5); Guidelines for U.S. Vessels Operating in High Risk Waters

    Science.gov (United States)

    2011-01-13

    ... Directive 104-6 (Rev 5); Guidelines for U.S. Vessels Operating in High Risk Waters AGENCY: Coast Guard, DHS... designated high risk waters, and provides additional counter-piracy guidance and mandatory measures for these... MARSEC Directives are available at your local Captain of the Port (COTP) office. Phone numbers and...

  20. Investigations of migratory birds during operation of Horns Rev offshore wind farm: Preliminary note of analysis of data from spring 2004

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Hounisen, J.P.

    2004-01-01

    In February 1998, the Ministry of the Environment gave Elsam A/S and Eltra A.m.b.a. approval to erect a wind farm, capable of producing 160 MW of electric power, at Horns Rev, west of Blaevandshuk off the west coast of Jutland. Construction activities at Horns Rev started in September 2001 and were finished in summer 2002. The entire project has been organised as a demonstration project to assess the technical, economic and environmental constraints on the future development of electric power production in Danish offshore environments. Within the framework of the environmental programme, bird investigations have been carried out in relation to the risk of collision between birds and wind turbines since 2002. To provide the latest update on the results from the bird investigations, this note presents results compiled during spring 2004 and deals with a preliminary analysis of effects on birds present at Horns Rev during commercial operation of the Horns Rev wind farm. Due to the remoteness of the area it has not been possible to obtain base-line investigation of bird occurrence and behaviour at the wind farm site. (au)

  1. Specificity of RSG-1.2 peptide binding to RRE-IIB RNA element of HIV-1 over Rev peptide is mainly enthalpic in origin.

    Science.gov (United States)

    Kumar, Santosh; Bose, Debojit; Suryawanshi, Hemant; Sabharwal, Harshana; Mapa, Koyeli; Maiti, Souvik

    2011-01-01

    Rev is an essential HIV-1 regulatory protein which binds to the Rev responsive element (RRE) present within the env gene of HIV-1 RNA genome. This binding facilitates the transport of the RNA to the cytoplasm, which in turn triggers the switch between viral latency and active viral replication. Essential components of this complex have been localized to a minimal arginine rich Rev peptide and stem IIB region of RRE. A synthetic peptide known as RSG-1.2 binds with high binding affinity and specificity to the RRE-IIB than the Rev peptide, however the thermodynamic basis of this specificity has not yet been addressed. The present study aims to probe the thermodynamic origin of this specificity of RSG-1.2 over Rev Peptide for RRE-IIB. The temperature dependent melting studies show that RSG-1.2 binding stabilizes the RRE structure significantly (ΔT(m) = 4.3°C), in contrast to Rev binding. Interestingly the thermodynamic signatures of the binding have also been found to be different for both the peptides. At pH 7.5, RSG-1.2 binds RRE-IIB with a K(a) = 16.2±0.6×10(7) M(-1) where enthalpic change ΔH = -13.9±0.1 kcal/mol is the main driving force with limited unfavorable contribution from entropic change TΔS = -2.8±0.1 kcal/mol. A large part of ΔH may be due to specific stacking between U72 and Arg15. In contrast binding of Rev (K(a) = 3.1±0.4×10(7) M(-1)) is driven mainly by entropy (ΔH = 0 kcal/mol and TΔS = 10.2±0.2 kcal/mol) which arises from major conformational changes in the RNA upon binding.

  2. Sociological investigation of the reception of Horns Rev and Nysted offshore wind farms in the local communities[Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, S.

    2005-03-15

    This annual report presents the work related to the sociological part of the socio-economic project on the local communities' reception of the Horns Rev Offshore Wind Farm, west of Blaavands Huk in Jutland, and the Nysted Offshore Wind Farm, south of Lolland. The project is part of the monitoring programme in connection with the construction of the offshore wind farms. Unlike projects, which examine the impact of the wind farms on nature, the socio-economic project did not start until 2003. The socio-economic project examines the effects on the local communities. Among other things the environmental-economic part of the project examines the preferences of the population in relation to location of the wind farm and the willingness to pay for increasing the distance between the wind farms and the coast. The sociological survey is qualitative. The survey is divided into three phases, as the aim is to investigate the public community's attitude towards the erection of an offshore wind farm before and after the construction of the wind farm. This aim is based on the assumption that attitudes may change once the wind farm is erected and the population has experienced the visibility of the wind farm, etc. The division into phases is as follows: 1) Phase 1 treats the conditions as they were before the erection of Nysted Offshore Wind Farm. 2) Phase 2 is an investigation of the development in attitudes towards Horns Rev Offshore Wind Farm a year after erection. 3) Phase 3 comprises a follow-up investigation of the local area at Nysted Offshore Wind Farm. This annual report treats phases 1 and 2. Phase 1 was carried out in April-August 2003, and the interviews at Nysted were thus made during the erection of the first offshore wind turbines. Phase 2 was carried out in September-November 2003. The follow-up investigation of the conditions in the local area around Nysted offshore wind farm is to be carried out in August-December 2004. The results of the investigations

  3. Expression of the clock gene Rev-erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism

    NARCIS (Netherlands)

    Sen, Satish; Dumont, Stéphanie; Sage-Ciocca, Dominique; Reibel, Sophie; de Goede, Paul; Kalsbeek, Andries; Challet, Etienne

    2018-01-01

    The nuclear receptor REV-ERBα is part of the molecular clock mechanism and is considered to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev-erbα (also known as Nr1d1) in the brain plays a role in the daily variations

  4. Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum.

    Directory of Open Access Journals (Sweden)

    Xiao-Yin Zhang

    2009-09-01

    Full Text Available Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents. These agents form highly toxic DNA crosslinks that cause extensive DNA damage. However, little is known about how Dictyostelium and the other "extremophiles" can tolerate and repair such large numbers of DNA crosslinks. Here we describe a comprehensive genetic analysis of crosslink repair in Dictyostelium discoideum. We analyse three gene groups that are crucial for a replication-coupled repair process that removes DNA crosslinks in higher eukarya: The Fanconi anaemia pathway (FA, translesion synthesis (TLS, and nucleotide excision repair. Gene disruption studies unexpectedly reveal that the FA genes and the TLS enzyme Rev3 play minor roles in tolerance to crosslinks in Dictyostelium. However, disruption of the Xpf nuclease subcomponent results in striking hypersensitivity to crosslinks. Genetic interaction studies reveal that although Xpf functions with FA and TLS gene products, most Xpf mediated repair is independent of these two gene groups. These results suggest that Dictyostelium utilises a distinct Xpf nuclease-mediated repair process to remove crosslinked DNA. Other DNA damage-resistant organisms and chemoresistant cancer cells might adopt a similar strategy to develop resistance to DNA crosslinking agents.

  5. Comment on “Diffusion of n-type dopants in germanium” [Appl. Phys. Rev. 1, 011301 (2014)

    International Nuclear Information System (INIS)

    Cowern, N. E. B.; Simdyankin, S.; Goss, J. P.; Napolitani, E.; De Salvador, D.; Bruno, E.; Mirabella, S.; Ahn, C.; Bennett, N. S.

    2015-01-01

    The authors of the above paper call into question recent evidence on the properties of self-interstitials, I, in Ge [Cowern et al., Phys. Rev. Lett. 110, 155501 (2013)]. We show that this judgment stems from invalid model assumptions during analysis of data on B marker-layer diffusion during proton irradiation, and that a corrected analysis fully supports the reported evidence. As previously stated, I-mediated self-diffusion in Ge exhibits two distinct regimes of temperature, T: high-T, dominated by amorphous-like mono-interstitial clusters—i-morphs—with self-diffusion entropy ≈30 k, and low-T, where transport is dominated by simple self-interstitials. In a transitional range centered on 475 °C both mechanisms contribute. The experimental I migration energy of 1.84 ± 0.26 eV reported by the Münster group based on measurements of self-diffusion during irradiation at 550 °C < T < 680 °C further establishes our proposed i-morph mechanism

  6. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Data report 2001

    International Nuclear Information System (INIS)

    Leonhard, S.B.; Pedersen, John

    2002-08-01

    The Ministry of Environment and Energy requested ELSAM and ELTRA to establish an offshore wind farm with an output of 150 MW in the waters of Horns Rev, approximately 15 km off Blaevandshuk, which is the most westerly point of Denmark. The first phase of construction of the wind farm have started in spring 2002. Before the construction activities take place, a baseline description of the benthos has been conducted as a part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines for offshore wind farms prepared by the Danish Energy Agency. The monitoring programme established for the benthic infauna was performed in spring 2001. In addition to a proposed fish investigation programme concerning the stomach contents of fish a comparative programme on benthos was established as part of the monitoring programme. The benthos sampling in connection with the fish programme was conducted in autumn 2001. This benthic survey includes sampling in a proposed reference area for the fish surveys north east of the wind farm. This report presents the data of the baseline environmental survey of the seabed in the wind farm site and in the proposed reference site and a brief description of the weather conditions at the time of sampling. (au)

  7. Numerical modelling of the flow in the resin infusion process on the REV scale: A feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Jabbari, M.; Spangenberg, J.; Hattel, J. H. [Process Modelling Group, Department of Mechanical Engineering, Technical University of Denmark, Nils Koppels Allé, 2800 Kgs. Lyngby (Denmark); Jambhekar, V. A.; Helmig, R. [Department of Hydromechanics and Modelling of Hydrosystems, Institute for Modelling Hydraulic and Environmental Systems, Universität Stuttgart, Stuttgart (Germany); Gersborg, A. R. [SCION DTU, Diplomvej 373N, DK-2800 Lyngby (Denmark)

    2016-06-08

    The resin infusion process (RIP) has developed as a low cost method for manufacturing large fibre reinforced plastic parts. However, the process still presents some challenges to industry with regards to reliability and repeatability, resulting in expensive and inefficient trial and error development. In this paper, we show the implementation of 2D numerical models for the RIP using the open source simulator DuMu{sup X}. The idea of this study is to present a model which accounts for the interfacial forces coming from the capillary pressure on the so-called representative elementary volume (REV) scale. The model is described in detail and three different test cases — a constant and a tensorial permeability as well as a preform/Balsa domain — are investigated. The results show that the developed model is very applicable for the RIP for manufacturing of composite parts. The idea behind this study is to test the developed model for later use in a real application, in which the preform medium has numerous layers with different material properties.

  8. A comprehensive experiment for molecular biology: Determination of single nucleotide polymorphism in human REV3 gene using PCR-RFLP.

    Science.gov (United States)

    Zhang, Xu; Shao, Meng; Gao, Lu; Zhao, Yuanyuan; Sun, Zixuan; Zhou, Liping; Yan, Yongmin; Shao, Qixiang; Xu, Wenrong; Qian, Hui

    2017-07-08

    Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of DNA polymerase ζ and SNPs in this gene are associated with altered susceptibility to cancer. This newly designed experiment is composed of three parts, including genomic DNA extraction, gene amplification by PCR, and genotyping by RFLP. By combining these activities, the students are not only able to learn a series of biotechniques in molecular biology, but also acquire the ability to link the learned knowledge with practical applications. This comprehensive experiment will help the medical students improve the conceptual understanding of SNP and the technical understanding of SNP detection. © 2017 by The International Union of Biochemistry and Molecular Biology, 45(4):299-304, 2017. © 2017 The International Union of Biochemistry and Molecular Biology.

  9. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev: results and conclusions 2000/2001

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I. [NERI, Dept. of Coastal Zone Ecology, Roskilde (Denmark)

    2001-07-01

    This report presents the combined results of two years of base-line investigations of birds performed during August 1999 - April 2001 in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. Based on the distribution of the most abundant bird species recorded during 13 aerial surveys, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, occurring in the areas north and south of Horns Rev, and with low numbers occurring on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although the common scoter was found in relatively high numbers on the southeast slopes of Horns Rev and within the wind farm area in the April 2001 survey. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affects less than 1% of the different species, except divers of which 1.65% will be affected. If the birds avoid the wind farm area and an adjacent 4 km zone (worst case scenario), it is estimated to affect 11% of the common scoter, 10% of the gannet, 7-9% of the divers, alcids and velvet scoter and 0-6% of the remaining species. The seasonal occurrence of the recorded species was fully comparable to the seasonal occurrence of these species recorded at Blaevandshuk since 1963. Year-to-year variation in abundance between the seasons August 1999 - April 2000 and August 2000 - April 2001 was mainly found in species that migrate through the Horns Rev area (terns, gannet, kittiwake), and with less pronounced variation in

  10. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev: results and conclusions 2000/2001

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2001-01-01

    This report presents the combined results of two years of base-line investigations of birds performed during August 1999 - April 2001 in relation to the proposed construction of an offshore wind farm at Horns Rev in the Danish part of the North Sea ca 14 km southwest of Blaevandshuk. Based on the distribution of the most abundant bird species recorded during 13 aerial surveys, there were no indications that the wind farm area was of any particular importance to the birds' exploitation of the Horns Rev area. Fish-eating species like divers, gannet, terns, auks and gulls generally showed scattered and variable distributions, occurring in the areas north and south of Horns Rev, and with low numbers occurring on the reef proper and within the planned wind farm area. The distribution of benthic foraging species, eider and common scoter, showed that they mainly exploited the coastal parts of the area off Blaevandshuk and Skallingen, although the common scoter was found in relatively high numbers on the southeast slopes of Horns Rev and within the wind farm area in the April 2001 survey. Preference analyses of bird exploitation of the Horns Rev area showed that if the birds completely avoid the wind farm area after erection of the wind turbines, this will affects less than 1% of the different species, except divers of which 1.65% will be affected. If the birds avoid the wind farm area and an adjacent 4 km zone (worst case scenario), it is estimated to affect 11% of the common scoter, 10% of the gannet, 7-9% of the divers, alcids and velvet scoter and 0-6% of the remaining species. The seasonal occurrence of the recorded species was fully comparable to the seasonal occurrence of these species recorded at Blaevandshuk since 1963. Year-to-year variation in abundance between the seasons August 1999 - April 2000 and August 2000 - April 2001 was mainly found in species that migrate through the Horns Rev area (terns, gannet, kittiwake), and with less pronounced variation in

  11. RevSex duplication-induced and sex-related differences in the SOX9 regulatory region chromatin landscape in human fibroblasts.

    Science.gov (United States)

    Lybæk, Helle; de Bruijn, Diederik; den Engelsman-van Dijk, Anke H A; Vanichkina, Darya; Nepal, Chirag; Brendehaug, Atle; Houge, Gunnar

    2014-03-01

    It was recently shown that duplications of the RevSex element, located 0.5 Mb upstream of SOX9, cause XX-disorder of sex development (DSD), and that deletions cause XY-DSD. To explore how a 148 kb RevSex duplication could have turned on gonadal SOX9 expression in the absence of SRY in an XX-male, we examined the chromatin landscape in primary skin fibroblast cultures from the index, his RevSex duplication-carrier father and six controls. The ENCODE project supports the notion that chromatin state maps show overlap between different cell types, i.e., that our study of fibroblasts could be of biological relevance. We examined the SOX9 regulatory region by high-resolution ChIP-on-chip experiments (a kind of "chromatin-CGH") and DNA methylation investigations. The RevSex duplication was associated with chromatin changes predicting better accessibility of the SRY-responsive TESCO enhancer region 14-15 kb upstream of SOX9. Four kb downstream of the TESCO evolutionary conserved region, a peak of the enhancer/promoter-associated H3K4me3 mark was found together with a major dip of the repressive H3K9me3 chromatin mark. Similar differences were also found when three control males were compared with three control females. A marked male/female difference was a more open chromatin signature in males starting ~400 kb upstream of SOX9 and increasing toward the SOX9 promoter. In the RevSex duplication-carrier father, two positions of DNA hypomethylation were also found, one corresponding to the H3K4me3 peak mentioned above. Our results suggest that the RevSex duplication could operate by inducing long-range epigenetic changes. Furthermore, the differences in chromatin state maps between males and females suggest that the Y chromosome or X chromosome dosage may affect chromatin conformation, i.e., that sex-dependent gene regulation may take place by chromatin modification.

  12. s |-|~o RT"? REv

    African Journals Online (AJOL)

    subserving any useful function)”. Tumour arising from any portion of the eyeball either on thesurface or within the eyeball constitutes an ocular neoplasm. Ocular tumours may be benign with a slow propensity to proliferation. Metastasis is rare. However, the function may be compromised due too compression of.

  13. Nuclear Power Plants (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Lyerly, Ray L.; Mitchell III, Walter [Southern Nuclear Engineering, Inc.

    1973-01-01

    Projected energy requirements for the future suggest that we must employ atomic energy to generate electric power or face depletion of our fossil-fuel resources—coal, oil, and gas. In short, both conservation and economic considerations will require us to use nuclear energy to generate the electricity that supports our civilization. Until we reach the time when nuclear power plants are as common as fossil-fueled or hydroelectric plants, many people will wonder how the nuclear plants work, how much they cost, where they are located, and what kinds of reactors they use. The purpose of this booklet is to answer these questions. In doing so, it will consider only central station plants, which are those that provide electric power for established utility systems.

  14. Electricity and Man (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Asimov, Isaac

    1974-01-01

    Our whole industrial civilization depends upon cheap energy streaking out in all directions and under fingertip controls—and that would be very difficult without electric current. It would take enormous ingenuity to find substitutes. If all electricity were shut off, then all electronic devices would be dead. Electric lights would darken. Aluminum would become a rare metal. All factories would have to develop power sources on the spot and would have to switch to primitive, mechanical controls. Every house and every farm would have to give up items we have come to take for granted—not only electric lights, but electric irons, electric toasters, electric water pumps, electric control of furnaces, and so on.

  15. Premixed Supersonic Combustion (Rev)

    Science.gov (United States)

    2015-02-20

    calculated using the 1-D separated flow model for the isolator described in Heiser and Pratt (Ref. 19). Several curves are shown. The green curve corresponds...Report 88-3059, 1988. [18] Krauss, R.H. and McDaniel, J.C., “A Clean Air Continuous Flow Propulsion Facility,” AIAA Report 92-3912, 1992. [19] Heiser

  16. Radiotherapy. 2. rev. ed.

    International Nuclear Information System (INIS)

    Wannenmacher, Michael; Debus, Juergen; Wenz, Frederik

    2013-01-01

    The purpose of this medical specialty book, besides presenting the state of the art in clinical radiotherapy and radiooncology, is to explain the basic principles of medical physics and radiobiology. Following a number of chapters on general topics and theory it provides detailed coverage of the individual organ systems, briefly addressing future aspects in the process. The authors relate their view that radiooncology as a medical specialty will continue to be under pressure to change and that it will take continuous innovation to secure its status within the interdisciplinary context around the treatment of cancer patients. The authors of this, the textbook's second edition, have dedicated much space to modern methods and techniques in order to do justice to these developments.

  17. Whole Body Counters (rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Woodburn, John H. [Walter Johnson High School, Rockville, MD; Lengemann, Frederick W. [Cornell University

    1967-01-01

    Whole body counters are radiation detecting and measuring instruments that provide information about the human body. This booklet describes different whole body counters, scientific principles that are applied to their design, and ways they are used.

  18. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

    International Nuclear Information System (INIS)

    Leonhard, S.B.; Pedersen, John

    2002-08-01

    A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

  19. Revival and emended description of 'Mycobacterium paraffinicum' Davis, Chase and Raymond 1956 as Mycobacterium paraffinicum sp. nov., nom. rev.

    Science.gov (United States)

    Toney, Nadege; Adekambi, Toidi; Toney, Sean; Yakrus, Mitchell; Butler, W Ray

    2010-10-01

    The omission of the name 'Mycobacterium paraffinicum' from the Approved Lists of Bacterial Names was due to phenotypic confusion surrounding a close relationship with Mycobacterium scrofulaceum. Correspondingly, 'M. paraffinicum' strains grew slowly in > 7 days, stained acid-alcohol-fast and produced yellow-pigmented, smooth, waxy colonies in the dark at an optimal temperature of 35°C. However, 'M. paraffinicum' strains demonstrated no activity for urease, nicotinamidase or pyrazinamidase and lacked growth at 42°C, unlike M. scrofulaceum. The mycolic acid pattern, as determined by HPLC, clustered 'M. paraffinicum' with M. scrofulaceum, Mycobacterium avium and Mycobacterium parascrofulaceum. Strains were fully susceptible to linezolid, rifabutin, clarithromycin and amikacin. Examination of the historical reference strain of 'M. paraffinicum', ATCC 12670, and five additional isolates using comparative studies with 16S rRNA, hsp65 and rpoB gene and concatenated sequences showed that they formed a tight taxonomic group that was distinct from similar non-tuberculous mycobacteria. Multilocus enzyme electrophoresis (MEE) analysis confirmed a close association of the five additional isolates with the reference strain of 'M. paraffinicum' with a genetic distance of 0.12 and showed that all six strains were distinct from other closely related species. These genetic results provided unambiguous evidence of the uniqueness of this slowly growing, scotochromogenic species and supported the revival of the name as Mycobacterium paraffinicum (ex Davis, Chase and Raymond 1956) sp. nov., nom. rev. We propose the previously deposited reference strain ATCC 12670(T) =DSM 44181(T) =NCIMB 10420(T), located in collections worldwide, as the type strain.

  20. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S.B.; Pedersen, John

    2002-08-15

    A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

  1. Horns Rev offshore wind farm. Introducing hard bottom substrate sea bottom and marine biology. Status report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, S B; Pedersen, John

    2002-08-15

    A baseline description of the benthos was carried out in spring and autumn 2001 prior to the construction of an offshore wind farm at Horns Rev, situated approximately 15 km off Blaevands Huk, which is Denmark's most westerly point. The surveys have been conducted as part of an environmental monitoring programme for the introduction of hard bottom substrates in the North Sea. The establishment of a monitoring programme is required according to some environmental guidelines set up by the Danish Energy Agency for offshore wind farms. Because no environmental criteria existed for benthic communities in connection with the construction activities, no power analysis was made prior to the design of the monitoring programme. The monitoring programme established for the benthic infauna is thus somewhat limited and only major changes in the community structure are expected to be detectable. The baseline description for the benthic infauna can also be used for comparison of the stomach contents of fish in a comparative programme. A newly defined reference area may be introduced for the fish programme why sampling in this area was carried out in the autumn 2001. Samples were recovered at a total of 18 stations at 6 wind turbine locations in the wind farm area in June 2001 and at a total of 9 stations at 3 wind turbine locations in September 2001. In September additional sampling was carried out at 5 stations in a designated reference area. At the wind turbine locations sampling was carried out at 3 stations located 5, 25 and 100 m from the edge of the planned scour protection. Samples were analysed for sediment characteristics and for benthic infauna. Only the benthos relating to the macrofauna was investigated during the surveys. (au)

  2. Final Report - DuraMelter 100 Tests to Support LAW Glass Formulation Correlation Development, VSL-06R6480-1, Rev. 0

    Energy Technology Data Exchange (ETDEWEB)

    Kruger, Albert A.; Muller, I. S.; Gong, W.; Pegg, I. L.; Matlack, K. S.

    2013-12-03

    This report describes the results of work and testing specified by Test Specifications 24590-LAW-TSP-RT-04-004, Rev. 0, Test Plans VSL-05T5480-1, Rev. 0 and Text Exceptions 24590-LAW-TEF-RT-05-00002. The work and any associated testing followed established quality assurance requirements and was conducted as authorized. The descriptions provided in this test report are an accurate account of both the conduct of the work and the data collected. Results required by the Test Plan are reported. Also reported are any unusual or anomalous occurences that are different from the starting hypotheses. The test results and this report have been reviewed and verified.

  3. Administrative circular No.14 (Rev. 3) – Protection of members of the personnel against the financial consequences of illness, accident and incapacity for work

    CERN Multimedia

    2013-01-01

    Administrative Circular No. 14 (Rev. 3) entitled “Protection of members the personnel against the financial consequences of illness, accident and incapacity for work”, approved by the Director-General following discussion at the Standing Concertation Committee meeting of 19 April 2012 and entering into force on 1 January 2013, is available on the intranet site of the Human Resources Department.   This circular is applicable to all members of the personnel. It cancels and replaces Administrative Circular No. 14 (Rev. 2) entitled “Protection of members of the personnel against the financial consequences of illness, accident and disability” from July 2006. The circular was revised in order to improve the procedure before the Joint Advisory Rehabilitation and Disability Board (JARDB) and the management of long-term sick leave through a multidisciplinary approach launched upstream. The aim of this approach is to allow staff/fellows c...

  4. Administrative Circular No. 2 (Rev. 6) – Recruitment, appointment and possible developments regarding the contractual position of staff members (1 January 2015)

    CERN Multimedia

    2014-01-01

    Administrative Circular No. 2 (Rev. 6) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 27 November 2014 is available on the Human Resources Department website. It cancels and replaces Administrative Circular No. 2 (Rev. 5) entitled "Recruitment, appointment and possible developments regarding the contractual position of staff members" of September 2011. This circular was revised in order to improve the effectiveness of the career transition measures, in particular by expanding the scope of the programme to include also career transition within the Organization and by placing emphasis on career orientation and job search. Administrative Circular No. 2 will be further revised next year with the adoption of the new contract policy, subject to approval of the relevant amendments by all competent bodies. ...

  5. IMMUNE RESPONSES OF GOATS (SHAMI BREED TO VACCINATION WITH A FULL, REDUCED AND CONJUNCTIVAL DOSE OF BRUCEVAC (BRUCELLA MELITENSIS REV.1 VACCINE

    Directory of Open Access Journals (Sweden)

    F. ALDOMY, M. ALKHAWALDEH1 AND I. B. YOUNIS

    2009-10-01

    Full Text Available Three groups of Shami goats were randomly vaccinated with Brucevac (Rev. 1 vaccine. Group 1 was vaccinated subcutaneously with a full dose (1.54 x 109 organisms. Group 2 was vaccinated conjunctively with one eye drop (5.2 x 108 organisms, while Group 3 was injected subcutaneously with a reduced dose (7.1 x 105 organisms of vaccine. Blood samples were collected before vaccination, two, four, eight, 15 and 24 weeks post vaccination. All samples were tested through CFT, ELISA, SAT and Rose Bengal plate test. All serological tests used detected a higher percentage of vaccinated female kids with a full dose than they did in other groups vaccinated with a reduced dose or with a conjunctival dose of Rev.1 vaccine. The overall results suggested that 100% of animals vaccinated with a conjunctival dose became positive to CFT at two, four, eight and 15 weeks post vaccination, and then the percentage of seropositive animals declined and became 20% at 24 weeks post inoculation. The conjunctival route of vaccination significantly reduced the intensity and duration of the post vaccination serological response, which makes the use of this vaccine compatible with brucellosis programmes, even when these are based on a test-and–slaughter policy. The overall results showed that Shami goats responded to Rev.1 vaccine in the expected way. The majority of animals were seropositive to the CFT by two weeks after vaccination with higher numbers of seropositive animals in the kids group vaccinated with a full dose of Rev.1 vaccine.

  6. Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-15

    The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  7. Finanšu pārskata revīzija un tās gaita uzņēmumā SIA “X”

    OpenAIRE

    Pocjus, Evita

    2016-01-01

    Diplomdarba tēma: „Finanšu pārskata revīzija un tās gaita uzņēmumā SIA „X”” Finanšu pārskata revīzija ir būtiska, jo arī Latvijas Zvērināto revidentu asociācijas apkopotie statistikas dati norāda, ka Latvijā ~90% no pirmreizēji revidētiem uzņēmumiem tiek atklātas būtiskas neatbilstības grāmatvedības uzskaitē, tās atbilstībai LR likumiem un normatīviem aktiem, kā arī finanšu pārskata sagatavošanā. Finanšu pārskata revīzija ir nepieciešama katram uzņēmumam, kurš grib iegūt klientu un sadarbība...

  8. Review report 2003. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-09-15

    The present review report presents the two wind farms Homs Rev and Nysted, with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on methods, programmes and conclusions can be found in these reports. This review report is divided into two parts. The first part contains a description of the potential environmentally impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Hors Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated at the bdsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  9. Review report 2004. The Danish offshore wind farm demonstration project: Horns Rev and Nysted offshore wind farms. Environmental impact assessment and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-10-15

    The present review report presents the two wind farms Horns Rev and Nysted with regard to environmental characteristics and the results of the environmental studies carried out in connection with the Environmental Impact Assessment (EIA) and the baseline and monitoring programmes at the two sites. The descriptions of the programmes are based on extracts from the individual annual reports. Detailed information on method, programmes and conclusions can be found in these reports (see Appendix 1). This review report is divided into two parts. The first part contains a description of the potential environmental impacts of offshore wind farms and the potentially affected part of the environment. The second part includes a description of Horns Rev and Nysted Offshore Wind Farm and the environmental studies carried out here until the end of 2003. Appendix I is a list of the literature published on the studies carried out at Horns Rev and Nysted Offshore Wind Farm. Appendix II is a list of some of the literature relevant to the demonstration projects but not directly related to the projects. The offshore wind farm situated in the Roedsand area is officially denoted Nysted Offshore Wind Farm, and in the present report the denotation 'Nysted' will be used as well when referring to Nysted Offshore Wind Farm. The denotation Roedsand will be used when referring to the actual area Roedsand. (au)

  10. Situation analysis of physical independence of the equipment and safety circuits of Almaraz NPP regarding R.G. 1.75 rev.3 (2005); Analisis de la situacion de la independencia fisica de los equipos y circuitos electricos de seguridad de C. N. Almaraz respecto a la R. G. 1.75 rev 3 (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Seijas Portela, S.

    2010-07-01

    Situation analysis of physical independence of the electrical equipment and circuits CN safety Almaraz about R.G. 1.75 rev. 3. (2005) The aim of this paper is to present the work done in the analysis of the physical separation of redundant safety electrical equipment (emergency diesel generators, medium voltage, electrical cabinets, etc.) and physical separation of circuits and electrical conduits.

  11. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2002 - 31. December 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-04-15

    This annual report, which is a baseline and/or an evaluation of the effects of construction phase, is based on extracts from our consultants' annual reports. These annual reports are individual reports, in which surveys have been made during the year 2002 and reported in the beginning of 2003. Detailed information on methods, programmes and conclusions can be found in these reports. In general it should be noted that apparently the construction phase has not had any unintended effects on the parameters surveyed. Therefore we can also conclude that the protective measures established by Elsam, especially scaring devices/ramp-ups for marine mammals, have had the intended effect. Especially interesting parameters that should be mentioned are: Birds: The seagull species 'Herring Gulls' was found to be attracted by the wind farm during the construction period. The number of Divers has decreased, however statistically this decrease is very small as very few Divers have been observed under the baseline. Porpoises: Porpoises generally stayed away from the construction area during pile driving. This effect was intended and scaring devices were deployed in order to ensure that the animals' hearing was not permanently damaged. Seals: The purpose of the programme has not been to show statistically significant effects during the construction phase. The purpose was to get an idea of their behaviour during the construction phase within the wind farm as well as on the reef. It has been concluded that Horns Rev is not used as a foraging area as much as expected. It is used as transit area for bigger foraging sites in the North Sea. Sand eels and Spisula: A baseline survey of sand eels within the wind farm area has been made. It is shown that sand eels are found in the wind farm area. Spisula have been found in the wind farm area but not in the amount expected. Hard substrate habitat: Baseline surveys on fish have been made during the spring of 2002. The

  12. Elsam. Offshore Wind Farm. Horns Rev. Annual status report for the environmental monitoring programme 1. January 2002 - 31. December 2002

    International Nuclear Information System (INIS)

    2003-04-01

    This annual report, which is a baseline and/or an evaluation of the effects of construction phase, is based on extracts from our consultants' annual reports. These annual reports are individual reports, in which surveys have been made during the year 2002 and reported in the beginning of 2003. Detailed information on methods, programmes and conclusions can be found in these reports. In general it should be noted that apparently the construction phase has not had any unintended effects on the parameters surveyed. Therefore we can also conclude that the protective measures established by Elsam, especially scaring devices/ramp-ups for marine mammals, have had the intended effect. Especially interesting parameters that should be mentioned are: Birds: The seagull species 'Herring Gulls' was found to be attracted by the wind farm during the construction period. The number of Divers has decreased, however statistically this decrease is very small as very few Divers have been observed under the baseline. Porpoises: Porpoises generally stayed away from the construction area during pile driving. This effect was intended and scaring devices were deployed in order to ensure that the animals' hearing was not permanently damaged. Seals: The purpose of the programme has not been to show statistically significant effects during the construction phase. The purpose was to get an idea of their behaviour during the construction phase within the wind farm as well as on the reef. It has been concluded that Horns Rev is not used as a foraging area as much as expected. It is used as transit area for bigger foraging sites in the North Sea. Sand eels and Spisula: A baseline survey of sand eels within the wind farm area has been made. It is shown that sand eels are found in the wind farm area. Spisula have been found in the wind farm area but not in the amount expected. Hard substrate habitat: Baseline surveys on fish have been made during the spring of 2002. The programme regarding the

  13. Analysis of mutagenic DNA repair in a thermoconditional mutant of Saccharomyces cerevisiae. IV. Influence of DNA replication and excision repair on REV2 dependent UV-mutagenesis and repair

    Energy Technology Data Exchange (ETDEWEB)

    Siede, W.; Eckardt, F.

    1986-01-01

    A double mutant being thermoconditionally defective in mutation induction as well as in repair of pre-lethal UV-induced DNA damage (rev2ts) and deficient in excision repair (rad3-2) was studied in temperature-shift experiments. The influence of inhibitors of DNA replication (hydroxyurea, aphidicolin) was determined. Additionally, an analysis of the dose-response pattern of mutation induction (mutation kinetics) at several ochre alleles was carried out. It was concluded that the UV-inducible REV2 dependent mutagenic repair process is not induced in excision-deficient cells. In excision-deficient cells, REV2 dependent mutation fixation is slow and mostly post-replicative though not dependent on DNA replication. The REV2 mediated mutagenic process could be separated from the repair function.

  14. Mr Huidong LI Deputy Chairman and Secretary-General, Rev. Committee of Chinese Nationalist Party Vice President, Sun Yat-Sen Culture Interchange Association of China Member, Committee for Internal and Judicial Affairs of the National People's Congress of China

    CERN Multimedia

    Bennett, Sophia Elizabeth

    2017-01-01

    Mr Huidong LI Deputy Chairman and Secretary-General, Rev. Committee of Chinese Nationalist Party Vice President, Sun Yat-Sen Culture Interchange Association of China Member, Committee for Internal and Judicial Affairs of the National People's Congress of China

  15. Grate Pallet 8232 (GP-8232) Vehicle Pallet, Evaluation Tests MIL-STD-1660, "Design Criteria for Ammunition Unit Loads" and TP-94-01 (REV 1), "Transportability Testing Procedures"

    National Research Council Canada - National Science Library

    Barickman, Philip

    2003-01-01

    .... The testing was conducted for informational purposes only. The GP-8232 Vehicle Pallet was evaluated by the testing procedures set forth in MIL-STD-1660 and TP-94-01 (Rev. 1) testing procedures...

  16. The role of hRev7, the accessory subunit of hPolζ, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE

    Directory of Open Access Journals (Sweden)

    Maher Veronica M

    2010-12-01

    Full Text Available Abstract Background DNA polymerase zeta (Polζ is a specialized DNA polymerase that, unlike classical replicative polymerases, is capable of replicating past DNA lesions, i.e. of performing translesion synthesis (TLS. The catalytic subunit of hPolζ, hRev3, has been shown to play a critical role in DNA damage-induced mutagenesis in human cells, but less is known about the role of hRev7, the accessory subunit of hPolζ, in such mutagenesis. To address this question, we recently generated human fibroblasts with very significantly reduced levels of hRev7 protein and demonstrated that hRev7 is required to protect cells from ultraviolet(254 nm (UV radiation-induced cytotoxicity and mutagenesis (McNally et al., DNA Repair 7 (2008 597-604. The goal of the present study was to determine whether hRev7 is similarly involved in the tolerance of DNA damage induced by benzo[a]pyrene diol epoxide (BPDE, the reactive form of the widespread environmental carcinogen benzo[a]pyrene. Methods To determine whether hRev7 also plays a role in protecting human cells from the cytotoxicity and mutagenesis induced by benzo[a]pyrene diol epoxide (BPDE, cell strains with reduced hRev7 were compared to their parental strain and a vector control strain for the effect of BPDE on cell survival, induction of mutations, and the ability to progress through the cell cycle. Results The results show that cell strains with reduced hRev7 are more sensitive to the cytotoxic effect of BPDE than the control strains, and progress through S-phase at a slower rate than the control cells following BPDE treatment, indicating that hRev7, and likely hPolζ, is required for efficient bypass of BPDE-induced DNA lesions. However, neither the frequency nor kinds of mutations induced by BPDE in cells with reduced hRev7 differ significantly from those induced in the control strains, suggesting that hPolζ is not essential for inserting nucleotides opposite BPDE-induced DNA damage. Conclusions Taken

  17. Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression

    International Nuclear Information System (INIS)

    Nguyen, Kim-Lien; Llano, Manuel; Akari, Hirofumi; Miyagi, Eri; Poeschla, Eric M.; Strebel, Klaus; Bour, Stephan

    2004-01-01

    Two HIV-1 accessory proteins, Vpu and Vif, are notoriously difficult to express autonomously in the absence of the viral Tat and Rev proteins. We examined whether the codon bias observed in the vpu and vif genes relative to highly expressed human genes contributes to the Rev dependence and low expression level outside the context of the viral genome. The entire vpu gene as well as the 5' half of the vif gene were codon optimized and the resulting open reading frames (ORFs) (vphu and hvif, respectively) were cloned in autonomous expression vectors under the transcriptional control of the CMV promoter. Codon optimization efficiently removed the expression block observed in the native genes and allowed high levels of Rev- and Tat-independent expression of Vpu and Vif. Most of the higher protein levels detected are accounted for by enhanced steady-state levels of the mRNA encoding the optimized species. Nuclear run-on experiments show for the first time that codon optimization has no effect on the rate of transcriptional initiation or elongation of the vphu mRNA. Instead, optimization of the vpu gene was found to stabilize the vphu mRNA in the nucleus and enhance its export to the cytoplasm. This was achieved by allowing the optimized mRNA to use a new CRM1-independent nuclear export pathway. This work provides a better understanding of the molecular mechanisms underlying the process of codon optimization and introduces novel tools to study the biological functions of the Vpu and Vif proteins independently of other viral proteins

  18. Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors.

    Science.gov (United States)

    López-Lastra, M; Gabus, C; Darlix, J L

    1997-11-01

    The murine leukemia virus (MLV)-related type C viruses constitute a major class of retroviruses that includes numerous endogenous and exogenous mammalian viruses and the related avian spleen necrosis virus (SNV). The MLV-related viruses possess a long and multifunctional 5' untranslated leader involved in key steps of the viral life cycle--splicing, translation, RNA dimerization, encapsidation, and reverse transcription. Recent studies have shown that the 5' leader of Friend murine leukemia virus and Moloney murine leukemia virus can direct cap independent translation of gag precursor proteins (Berlioz et al., 1995; Vagner et al., 1995b). These data, together with structural homology studies (Koning et al., 1992), prompted us to undertake a search for new internal ribosome entry segment (IRES) of retroviral origin. Here we describe an IRES element within the 5' leader of avian reticuloendotheliosis virus type A (REV-A) genomic RNA. Data show that the REV-A 5' IRES element maps downstream of the packaging/dimerization (E/DLS) sequence (Watanabe and Temin, 1982; Darlix et al., 1992) and the minimal IRES sequence appears to be within a 129 nt fragment (nucleotides 452-580) of the 5' leader, immediately upstream of the gag AUG codon. The REV-A IRES has been successfully utilized in the construction of novel high titer MLV-based retroviral vectors, containing one or more IRES elements of retroviral origin. These retroviral constructs, which represent a starting point for the design of novel vectors suitable for gene therapy, are also of interest as a model system of internal translation initiation and its possible regulation during development, cancer, or virus infection.

  19. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev, and results from the year of construction

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2003-01-01

    The present report presents the base-line investigations of birds conducted during August 1999-April 2001 in relation to construction of an offshore wind farm at Horns Rev, 14 km west-south-west of Blaevandshuk, in the Danish North Sea. The report also presents data collected during the period September 2001-April 2002, when construction of the wind farm was in progress. The wind farm will consist of 80 wind turbines, each of 2 MW, and cover an area of c. 20 km 2 . The eastern part of the North Sea constitutes major staging and wintering grounds for huge numbers of water- and seabirds. The area is also known to be an important site for migrating birds, which especially in autumn pass in large numbers. As Denmark has obligations to protect and maintain the bird populations it was laid down in the approval for erection of the wind farm that the impact on birds should be investigated. According to the 1% criteria defined in the Ramsar Convention, the eastern part of the North Sea including the wind farm area is of international importance to divers, Common Tern, and Sandwich Tern. A number of other species, e.g. Common Eider, Common Scoter, Guillemot and Razorbill, are present in the area in significant numbers as well, though these numbers do not make up 1% of the populations. Detailed distributions of birds in the area around and at Horns Rev were virtually unknown until initiation of this project. Previous bird counts in this area have been carried out almost exclusively from the coast and detailed knowledge exists concerning the numbers of roosting at and migrating birds from the westernmost point of Jutland, Blaevandshuk. To describe the numbers and distributions of birds staging and wintering in the Horns Rev area, bird investigations were initiated in 1999 by using standardised transect counts from aircraft. Up to April 2002, 18 aerial counts have been carried out over an area of c. 1,700 km 2 centred on the Horns Rev project area. (au)

  20. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev, and results from the year of construction

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2003-04-15

    The present report presents the base-line investigations of birds conducted during August 1999-April 2001 in relation to construction of an offshore wind farm at Horns Rev, 14 km west-south-west of Blaevandshuk, in the Danish North Sea. The report also presents data collected during the period September 2001-April 2002, when construction of the wind farm was in progress. The wind farm will consist of 80 wind turbines, each of 2 MW, and cover an area of c. 20 km{sup 2}. The eastern part of the North Sea constitutes major staging and wintering grounds for huge numbers of water- and seabirds. The area is also known to be an important site for migrating birds, which especially in autumn pass in large numbers. As Denmark has obligations to protect and maintain the bird populations it was laid down in the approval for erection of the wind farm that the impact on birds should be investigated. According to the 1% criteria defined in the Ramsar Convention, the eastern part of the North Sea including the wind farm area is of international importance to divers, Common Tern, and Sandwich Tern. A number of other species, e.g. Common Eider, Common Scoter, Guillemot and Razorbill, are present in the area in significant numbers as well, though these numbers do not make up 1% of the populations. Detailed distributions of birds in the area around and at Horns Rev were virtually unknown until initiation of this project. Previous bird counts in this area have been carried out almost exclusively from the coast and detailed knowledge exists concerning the numbers of roosting at and migrating birds from the westernmost point of Jutland, Blaevandshuk. To describe the numbers and distributions of birds staging and wintering in the Horns Rev area, bird investigations were initiated in 1999 by using standardised transect counts from aircraft. Up to April 2002, 18 aerial counts have been carried out over an area of c. 1,700 km{sup 2} centred on the Horns Rev project area. (au)

  1. Evaluación de dos bombas hidráulicas de engranajes de desplazamientos 32 y 50 cm3/rev

    OpenAIRE

    Pedro Paneque Rondón; Eugenio Romantchik Kriuskova; Luciano Pérez Sobrevilla; Remigio Durán Hernández; Ricardo Castillo Calderín

    2013-01-01

    Como parte de las investigaciones que se llevan a cabo en la Universidad Agraria de La Habana (UNAH), en el Centro de Mecanización Agro- pecuaria (CEMA), con la cooperación de la Universidad Autónoma Chapingo (UACh), en el Departamento de Ingeniería Mecánica Agrícola (DIMA), dirigidas al desarrollo de la Oleohidráulica, se sometieron a evaluación dos bombas de engranajes de la marca Caproni de fabricación búlgara, con desplazamientos o cilindradas de 32 y 50 cm3/rev, refiriéndose la prueba a ...

  2. Anticoking Coatings for High Temperature Petrochemical Reactors Revêtements pour réacteurs pétrochimiques à cokage réduit

    Directory of Open Access Journals (Sweden)

    Ropital F.

    2006-12-01

    Full Text Available Coke deposition is a major problem for several refinery and petrochemical processes, among which steam cracking for ethylene production. Decreasing coking rates will reduce decoking frequency and will also decrease heat transfer degradation. For these processes, a means of reducing coking phenomena is the application of anticoking coatings on the reactor walls. For this purpose a methodology was developed under a CEC Brite-Euram project with steam cracking as the main application. A first selection of the coatings and their techniques of deposition was performed according to their composition (non catalytic compounds, their resistance to carburization and oxidation and also according to the nature of the substrate. The feasibility of coating deposition was studied for small diameter furnace tubes and the techniques were perfected in particular with respect to the physicochemical characterization of the coatings and their resistance during thermal cycling and coking-decoking cycles. For the thermal cycling and the coking evaluation, industrial conditions were reproduced as closely as possible. For coking tests, a microreactor with complete mixing of the gas phase was developed for temperatures up to 950°C. The coking behavior of the coated samples was compared with conventional refractory alloys: reduction of the coking rate by a factor of 3 was measured with the most promising coating. This work was completed by the kinetic modelling of coking on uncoated materials. La formation de coke est un problème crucial pour de nombreux procédés pétrochimiques. Ralentir le cokage permet de réduire la fréquence des décokages et de limiter la dégradation du transfert thermique. Un des moyens envisageables pour réduire le cokage est le dépôt d'un revêtement à la paroi de ces réacteurs. La mise au point de tels revêtements a fait l'objet d'un projet de recherche européen Brite-Euram, pour lequel le vapocraquage a été la principale

  3. Model-based investigation of the circadian clock and cell cycle coupling in mouse embryonic fibroblasts: Prediction of RevErb-α up-regulation during mitosis.

    Science.gov (United States)

    Traynard, Pauline; Feillet, Céline; Soliman, Sylvain; Delaunay, Franck; Fages, François

    2016-11-01

    Experimental observations have put in evidence autonomous self-sustained circadian oscillators in most mammalian cells, and proved the existence of molecular links between the circadian clock and the cell cycle. Some mathematical models have also been built to assess conditions of control of the cell cycle by the circadian clock. However, recent studies in individual NIH3T3 fibroblasts have shown an unexpected acceleration of the circadian clock together with the cell cycle when the culture medium is enriched with growth factors, and the absence of such acceleration in confluent cells. In order to explain these observations, we study a possible entrainment of the circadian clock by the cell cycle through a regulation of clock genes around the mitosis phase. We develop a computational model and a formal specification of the observed behavior to investigate the conditions of entrainment in period and phase. We show that either the selective activation of RevErb-α or the selective inhibition of Bmal1 transcription during the mitosis phase, allow us to fit the experimental data on both period and phase, while a uniform inhibition of transcription during mitosis seems incompatible with the phase data. We conclude on the arguments favoring the RevErb-α up-regulation hypothesis and on some further predictions of the model. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Fader, Kelly A.; Nault, Rance [Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Kirby, Mathew P.; Markous, Gena [Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Matthews, Jason [Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo 0316 (Norway); Zacharewski, Timothy R., E-mail: tzachare@msu.edu [Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824 (United States); Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States)

    2017-04-15

    Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production. To further characterize the role of Fe in AhR-mediated hepatotoxicity, male C57BL/6 mice were orally gavaged with sesame oil vehicle or 0.01–30 μg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) every 4 days for 28 days. Duodenal epithelial and hepatic RNA-Seq data were integrated with hepatic AhR ChIP-Seq, capillary electrophoresis protein measurements, and clinical chemistry analyses. TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine. Total hepatic Fe levels were negligibly increased while transferrin saturation remained unchanged. Furthermore, TCDD elicited dose-dependent gene expression changes in heme biosynthesis including the induction of aminolevulinic acid synthase 1 (Alas1) and repression of uroporphyrinogen decarboxylase (Urod), leading to a 50% increase in hepatic hemin and a 13.2-fold increase in total urinary porphyrins. Consistent with this heme accumulation, differential gene expression suggests that heme activated BACH1 and REV-ERBα/β, causing induction of heme oxygenase 1 (Hmox1) and repression of fatty acid biosynthesis, respectively. Collectively, these results suggest that Hamp repression, Fe accumulation, and increased heme levels converge to promote oxidative stress and the progression of TCDD-elicited hepatotoxicity. - Highlights: • TCDD represses hepatic hepcidin expression, leading to systemic iron overloading. • Dysregulation of heme biosynthesis is consistent with heme and porphyrin accumulation. • Heme-activated REV-ERBα/β repress circadian-regulated hepatic lipid metabolism. • Disruption of iron

  5. Dosimetric characterization of model Cs-1 Rev2 cesium-131 brachytherapy source in water phantoms and human tissues with MCNP5 Monte Carlo simulation

    International Nuclear Information System (INIS)

    Wang Jianhua; Zhang Hualin

    2008-01-01

    A recently developed alternative brachytherapy seed, Cs-1 Rev2 cesium-131, has begun to be used in clinical practice. The dosimetric characteristics of this source in various media, particularly in human tissues, have not been fully evaluated. The aim of this study was to calculate the dosimetric parameters for the Cs-1 Rev2 cesium-131 seed following the recommendations of the AAPM TG-43U1 report [Rivard et al., Med. Phys. 31, 633-674 (2004)] for new sources in brachytherapy applications. Dose rate constants, radial dose functions, and anisotropy functions of the source in water, Virtual Water, and relevant human soft tissues were calculated using MCNP5 Monte Carlo simulations following the TG-43U1 formalism. The results yielded dose rate constants of 1.048, 1.024, 1.041, and 1.044 cGy h -1 U -1 in water, Virtual Water, muscle, and prostate tissue, respectively. The conversion factor for this new source between water and Virtual Water was 1.02, between muscle and water was 1.006, and between prostate and water was 1.004. The authors' calculation of anisotropy functions in a Virtual Water phantom agreed closely with Murphy's measurements [Murphy et al., Med. Phys. 31, 1529-1538 (2004)]. Our calculations of the radial dose function in water and Virtual Water have good agreement with those in previous experimental and Monte Carlo studies. The TG-43U1 parameters for clinical applications in water, muscle, and prostate tissue are presented in this work

  6. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities; Orientaciones y sugerencias para la aplicacion del documento INFCIRC/225/Rev.4, proteccion fisica de los materiales y las instalaciones nucleares

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection.

  7. Mersin ilinde görev yapan hekimlerin meslek örgütüyle ilişkileri ve beklentileri

    Directory of Open Access Journals (Sweden)

    Ahmet Öner Kurt

    2011-12-01

    Full Text Available Amaç: Bu çalışmada; Mersin İlinde görev yapan hekimlerin meslek örgütü olan tabip odası ile ilişkilerinin boyutu ve odadan beklentilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Kesitsel tipteki bu çalışmada Mersin İlinde görev yapan toplam 1875 hekim evren olarak kabul edildi, örnek olarak 550 hekimin çalışmaya alınması hedeflendi. Çalışmaya alınacak hekimler; görev yeri, kurum, unvan ve cinsiyet oranına göre ağırlıklandırılarak tabakalı sistematik örnekleme yöntemi ile belirlendi. Veriler Kasım-Aralık 2009 tarihlerinde anket formu kullanılarak toplandı. Verilerin özetlenmesinde tanımlayıcı istatistikler ve değişkenlerin karşılaştırılmasında Ki-kare testi kullanıldı. Bulgular: Hekimlerin %69.1’i erkek, %82.5’i evli, %80.9’u kamu sağlık kurumlarında çalışıyor, %37.6’sı pratisyen hekim olarak görev yapıyordu. Hekimlerin ortalama görev süresi 17.4±9.6 (1–52 yıldı. Hekimlerin %77.1’i tabip odasına üye, %31.5’i son bir yılda tabip odası çalışmalarına katılmış ve %26.7’si bugünden sonraki süreçte tabip odası çalışmalarında görev almak istiyordu. Erkek, evli, özel sektörde çalışan, uzman olan, görev süresi 30 yıldan fazla olan ve çalışma koşullarının iyileştirilmesini bekleyen hekimlerin diğer gruplara göre tabip odasına daha fazla üye oldukları saptandı. Son bir yılda araştırma görevlileri tabip odası çalışmalarına daha az katılmıştı. Hekimlerin tabip odasından ilk sıradaki beklentisi; çalışma koşullarının iyileştirilmesiydi. Sonuç: Mersin’de dört hekimden birisinin tabip odasına üye olmaması, üçte ikisinin oda çalışmalarına katılmaması ve bugünden sonra da katılmayı düşünmemesi, hekimlerin örgütlü yaşamın gereklerini yeterince yerine getirmediğini ve meslek örgütlerine çok fazla sahip çıkmadığını düşündürmektedir. Tabip odaları üyelerinin odaya yakla

  8. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 304, Revision 1 (FGE.304Rev1): Four carboxamides from Chemical Groups 30

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate four flavouring substances in the Flavouring Group Evaluation 304, Revision 1 (FGE.304Rev1) using the Procedure in Commission Regulation (EC) No 1565...... criteria and identity for the materials of commerce have been provided for all four candidate substances....

  9. Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51).

    Science.gov (United States)

    Azimzadeh, Kaveh; Nasrollahi Nargesabad, Reza; Vousooghi, Nasim

    2017-08-01

    Brucellosis is known as one of important zoonosis. Studying the histological and biochemical effects of the disease could help to increase our knowledge about it. The aim of the present study was to evaluate changes of plasma parameters after intraperitoneal injection of two species of Brucella (Brucella melitensis and Brucella abortus) and two vaccines (Rev-1, RB-51) in the rat. Forty male rats were divided into five groups (n = 8 in each group). Two groups received suspensions of Brucella abortus and Brucella melitensis and two other groups were injected intraperitoneally with two mentioned vaccines and the last group received only distilled water. The results showed a significant increase in sphingosine 1-phosphate, Malondialdehyde, hepcidin, homocysteine, cardiac troponin I and copper levels and a considerable decrease in the levels of iron and zinc (P ≤ 0.01) in infected groups compared to the control animals. In vaccinated groups, hepcidin was increased but other parameters were not changed in comparison to the control group. It can be concluded that increase of homocysteine and cardiac troponin I in brucellosis could be a warning for cardiac adverse effects. Besides, increase of sphingosine 1-phosphate probably indicates its stimulant and modulatory effects in anti- Brucellosis biochemical pathways of the host. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. A Study on Improvement of Test Method of Nuclear Power Plant ESF ACS by applying Regulatory Guide 1.52 (Rev.3)

    International Nuclear Information System (INIS)

    Lee, Sook Kyung; Kim, Kwang Sin; Sohn, Soon Hwan; Song, Kyu Min; Lee, Kae Woo; Cho, Byoung Ho; Park, Jeong Seo; Yoo, Byeang Jea; Hong, Soon Joon; Kang, Sun Haeng

    2010-01-01

    U. S. NRC Regulation Guide 1.52 regulating ESF ACS in nuclear power plants has been revised to revision 3. To apply reduction of operability test time, allowance of alternative challenge agents for in-place leak test of HEPA filters, and upgrade of Methyl Iodide penetration acceptance criterion in activated carbon performance test suggested in Reg. Guide 1.52(Rev.3) on Yonggwang units 5 and 6 ESF ACSes, technical feasibility study was carried out with on-site experiments as well as experiments with a lab-scale model. It was confirmed that the moisture in the system returned to the level before the test in 1 or 4 days even though the moisture was removed during the operability test lasting more than 10 hours. Therefore, it is appropriate to perform monthly operability test in 15 minutes just long enough to check the operability of equipment. To change challenge material for in-place HEPA filter leak test, size of aerosol, production rate, and leak detection capability were compared for DOP and PAO. It was concluded that PAO can be substituted for DOP in nuclear power plants. The upgrade of Methyl Iodide penetration acceptance criterion from 0.175 % to 0.5 % in active carbon filter bed deeper than 4 inches was to conform to the change of activated carbon performance test method to ASTM D3803(1989). It was confirmed that Methyl Iodide penetration acceptance criterion of 0.5 % under 30 .deg. C

  11. Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα

    Directory of Open Access Journals (Sweden)

    Brown M Scott

    2010-12-01

    Full Text Available Abstract Background Alternative processing of α-thyroid hormone receptor (TRα, NR1A1 mRNAs gives rise to two functionally antagonistic nuclear receptors: TRα1, the α-type receptor, and TRα2, a non-hormone binding variant that is found only in mammals. TRα2 shares an unusual antisense coding overlap with mRNA for Rev-erbα (NR1D1, another nuclear receptor protein. In this study we examine the structure and expression of these genes in the gray short-tailed opossum, Monodelphis domestica, in comparison with that of eutherian mammals and three other marsupial species, Didelphis virginiana, Potorous tridactylus and Macropus eugenii, in order to understand the evolution and regulatory role of this antisense overlap. Results The sequence, expression and genomic organization of mRNAs encoding TRα1 and Rev-erbα are very similar in the opossum and eutherian mammals. However, the sequence corresponding to the TRα2 coding region appears truncated by almost 100 amino acids. While expression of TRα1 and Rev-erbα was readily detected in all tissues of M. domestica ages 0 days to 18 weeks, TRα2 mRNA was not detected in any tissue or stage examined. These results contrast with the widespread and abundant expression of TRα2 in rodents and other eutherian mammals. To examine requirements for alternative splicing of TRα mRNAs, a series of chimeric minigenes was constructed. Results show that the opossum TRα2-specific 5' splice site sequence is fully competent for splicing but the sequence homologous to the TRα2 3' splice site is not, even though the marsupial sequences are remarkably similar to core splice site elements in rat. Conclusions Our results strongly suggest that the variant nuclear receptor isoform, TRα2, is not expressed in marsupials and that the antisense overlap between TRα and Rev-erbα thus is unique to eutherian mammals. Further investigation of the TRα and Rev-erbα genes in marsupial and eutherian species promises to yield

  12. Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα

    Science.gov (United States)

    2010-01-01

    Background Alternative processing of α-thyroid hormone receptor (TRα, NR1A1) mRNAs gives rise to two functionally antagonistic nuclear receptors: TRα1, the α-type receptor, and TRα2, a non-hormone binding variant that is found only in mammals. TRα2 shares an unusual antisense coding overlap with mRNA for Rev-erbα (NR1D1), another nuclear receptor protein. In this study we examine the structure and expression of these genes in the gray short-tailed opossum, Monodelphis domestica, in comparison with that of eutherian mammals and three other marsupial species, Didelphis virginiana, Potorous tridactylus and Macropus eugenii, in order to understand the evolution and regulatory role of this antisense overlap. Results The sequence, expression and genomic organization of mRNAs encoding TRα1 and Rev-erbα are very similar in the opossum and eutherian mammals. However, the sequence corresponding to the TRα2 coding region appears truncated by almost 100 amino acids. While expression of TRα1 and Rev-erbα was readily detected in all tissues of M. domestica ages 0 days to 18 weeks, TRα2 mRNA was not detected in any tissue or stage examined. These results contrast with the widespread and abundant expression of TRα2 in rodents and other eutherian mammals. To examine requirements for alternative splicing of TRα mRNAs, a series of chimeric minigenes was constructed. Results show that the opossum TRα2-specific 5' splice site sequence is fully competent for splicing but the sequence homologous to the TRα2 3' splice site is not, even though the marsupial sequences are remarkably similar to core splice site elements in rat. Conclusions Our results strongly suggest that the variant nuclear receptor isoform, TRα2, is not expressed in marsupials and that the antisense overlap between TRα and Rev-erbα thus is unique to eutherian mammals. Further investigation of the TRα and Rev-erbα genes in marsupial and eutherian species promises to yield additional insight into the

  13. Quantum theory. 2. rev. ed.

    International Nuclear Information System (INIS)

    Mitter, H.

    1979-01-01

    This book is an introduction into quantum mechanics. After a general introduction the algebraic calculus of quantum mechanics in the framework of the Dirac brackets is described, whereby the probabilistic interpretation is introduced. Then some simple examples are described in this framework. After a description of the wave representation the general formalism of quantum mechanics is described. Then the Schroedinger equation is introduced. The angular momentum in quantum mechanics is then explicitely discussed. After a treatment of simple one- and two-body problems the parity and the probability current are discussed. Then the approximation methods are described. Finally some applications in atomic physics, simples many-body problems, and the scattering theory are dealed with. In the appendix the delta-function, orthogonal functions, the higher symmetry of the hydrogen problem, and the Galilei transformation in quantum mechanics are described. Every chapter conteins exercise problems. (HSI) [de

  14. Nuclear Propulsion for Space (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R; Schwenk, Francis C

    1971-01-01

    The operation of nuclear rockets and a description of the development of nuclear rockets in the U.S. is given. Early developments and Project Rover, Project Pluto, and the NERVA (Nuclear Engine for Rocket Vehicle Application) Program are detailed. The Nuclear Rocket Development Station facilities in Nevada are described. The possibilities and advantages of using nuclear rockets for missions beginning from an earth orbit and moving outward toward higher earth orbits, the moon, and the planets are discussed.

  15. Food Preservation by Irradiation (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Urrows, Grace M.

    1968-01-01

    Up to 30% of food harvests are lost in some parts of the world because of animal pests and microorganisms. Nuclear techniques can help reduce and extend the shelf life of these foods. Around 55 countries now have food irradiation programs. The use of radiation is the most recent step in man's attempts to preserve some of his harvest for the lean part of the year.

  16. Mineralogy. 2. rev., enlarged ed.

    International Nuclear Information System (INIS)

    Matthes, S.

    1987-01-01

    The textbook is intended for students with a basic knowledge of descriptive mineralogy and crystallography who wish to enhance their knowledge in the fields of determinative mineralogy, petrology, and the geology and genesis of mineral deposits. The material presented concentrates on the essential aspects of the subject fields and is completed by up-to-date information concerning the technical and economic significance of the minerals, rocks and ores as raw materials. With 165 figs., 2 tabs [de

  17. Project Execution Plan, Rev. 3

    International Nuclear Information System (INIS)

    IT Corporation, Las Vegas

    2002-01-01

    This plan addresses project activities encompassed by the U.S. Department of Energy's (DOE's), National Nuclear Security Administration Nevada Operations Office, Environmental Restoration Division and conforms to the requirements contained in the Life-Cycle Asset Management, DOE Order 430.1A; The Joint Program Office Policy on Project Management in Support of DOE Order 430.1; Program and Project Management for the Acquisition of Capital Assets, DOE Order 413.3; the Project Execution and Engineering Management Planning Guide, GPG-FM-010; and other applicable Good Practice Guides; and the FY 2001 Integrated Planning, Accountability, and Budgeting System Policy Guidance. The plan also reflects the milestone philosophies of the Federal Facility Agreement and Consent Order, as agreed to by the State of Nevada, the DOE, and the U.S. Department of Defense; and traditional project management philosophies such as the development of life-cycle costs, schedules, and work scope; identification o f roles and responsibilities; and baseline management and controls

  18. Subconsciously opposed. 2. rev. ed.

    International Nuclear Information System (INIS)

    Wuenschmann, A.

    1982-01-01

    The book deals with the emotional aspects of the controversy on peaceful use of nucleon energy. It would be self-delusion to expect a near end of the nuclear discussion. Advocates and opponents confront each other almost beyond reconcilation, handly prepared to hear the opposite side's arguments. What is the reason. As C.F. von Weizsaecker remarked to the author: 'To understand a phenomenon like the present nuclear energy debate is hardly possible without recurring to psychology'. In this paperback an entirely new approach to the nuclear energy debate is opened. The book has found wide attention. As the 'Neue Zuercher Zeitung' wrote: 'The author's psychology analysis of the nuclear energy controversy and especially its interpretation based on Jung's depth psychology combine to form a terse survey of many phenomena not so far systematically studied'. (orig.) [de

  19. The nuclear suicide. Rev. ed.

    International Nuclear Information System (INIS)

    Gruhl, H.

    1988-01-01

    The author, one of the most consistent opponents of nuclear power, strikes a balance after the Chernobyl catastrophe. He relentlessly analyses the 'German nuclear situation', developments to be expected from risks and catastrophic events. He exposes statements offered by the owners of power plants and by politicians as attempts to play risks down, and hopes to achieve a turnabout yet. The conjunction of technical and physical arguments with a fundamental criticism of the ideology of economic growth is what distinguishes this book from other publications critical of nuclear energy. But the author does not content himself with criticism, he goes on to point out realistic measures for opting out of nuclear energy. (orig./HSCH) With 10 figs. and maps [de

  20. Reactor handbook. 2. rev. ed.

    International Nuclear Information System (INIS)

    Lederer, B.J.; Wildberg, D.W.

    1992-01-01

    On the basis of the guidelines on expert knowledge, the book discusses the subjects of atomic physics, heat transfer, nuclear power plants, reactor materials, radiation protection, reactor safety, reactor instrumentation, and reactor operation, with special regard to nuclear power plants with LWR-type reactors. The book is intended for shift personnel, especially gang bosses, reactor operators, and control station operators: for this reason a practical and rather popular style has been chosen. However, the book will also be a manual for other operating personnel, personnel of producer companies, expert organisations, authorities, and students. It can be used as a textbook for staff training, a manual for the practice, and as accompanying book for teaching at nuclear engineering schools. (orig.) With 173 figs [de

  1. Animals in Atomic Research (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Ricciuti, Edward R. [Bronx Zoo

    1969-01-01

    This booklet explains what use animals are to science and why they are important to the development of nuclear energy for peaceful uses. It contains examples of the roles animals of many kinds play in the development of nuclear science for the well-being of mankind.

  2. 15 years of Rev Rene

    Directory of Open Access Journals (Sweden)

    Lorita Marlena Freitag Pagliuca

    2015-04-01

    Full Text Available Writing an editorial is always a challenge. When drafting a scientific paper one can rely on the literature review, method, results, and discussion with texts supporting or deconstructing what one wants to prove. Utopia is the spice of life, better when there are more than one utopian; particularly a group of dreamers who allowed themselves to dream, not worrying about immediate results; keen to build and preserve a 15-year history. Enter adolescence and be in the world. Create complicity to dream and achieve utopia.

  3. Environmental law. 3. rev. ed.

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    This pocketbook contains major federal regulations on environmental protection. They serve to protect and cultivate mankind's natural foundations of life, to preserve the environment. The environmental law is devided as follows: Constitutional law on the environment, common administrative law on the environment, special administrative law on the environment including conservation of nature and preservation of rural amenities, protection of waters, waste management, protection against nuisances, nuclear energy and radiation protection, energy conservation, protection against dangerous substances, private law relating to the environment, criminal law relating to the environment. (orig.) [de

  4. Nuclear Energy for Desalting (Rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Urrows, Grace M.

    1967-01-01

    This booklet discusses the huge demand for fresh clean water and various ways to create it. Since 3/4 of the world is covered in salt water, many processes have been developed to desalt the salt water. Nuclear-powered desalting units are discussed extensively.

  5. Eddy Current Testing at Level 2: Manual for the Syllabi Contained in IAEA-TECDOC-628.Rev. 2 'Training Guidelines for Non Destructive Testing Techniques'

    International Nuclear Information System (INIS)

    2011-01-01

    The International Atomic Energy Agency has been active in the promotion of non-destructive testing (NDT) technology in the world for many decades. The prime reason for this interest has been the need for stringent standards for quality control for safe operation of nuclear as well as other industrial installations. It has successfully executed a number of programmes including technical co-operation (TC) projects (national and regional) and the coordinated research projects (CRP) of which NDT was an important part. Through these programmes a large number of persons in the Member States have been trained, leading to establishment of national certifying bodies (NCB) responsible for training and certification of NDT personnel. Consequently, a state of self-sufficiency in this area of technology has been achieved in many of them. All along there has been a realization of the need to have well established training guidelines and related books in order, firstly, to guide the IAEA experts who were involved in this training programme and, secondly, to achieve some level of international uniformity and harmonization of training materials and consequent competence of NDT personnel. The syllabi for training courses have been published in the form of IAEA-TECDOC publications. The first was IAEA-TECDOC-407 (1987), which contained syllabi for the basic five methods, i.e. liquid penetrant testing, magnetic particle testing, eddy current testing, radiographic testing and ultrasonic testing. To accommodate advancements in NDT technology, later versions of this publication were issued in 1991, 2002 and 2008, the current version being IAEA-TECDOC-628/Rev.2 (2008), which includes additional and more advanced NDT methods. This IAEA-TECDOC, as well as most of the international standards on the subject of training and certification of NDT personnel including ISO 9712 (2005), define three levels of competence. Among these, level 1 is the lowest and level 3 the highest. The intermediate

  6. Development of a Computer Code, PZRTR rev 1, for the Thermal Hydraulic Analysis of a Multi-Cavity Cold Gas Pressurizer for an Integral Reactor, SMART-P

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Jae Kwang; Kang, H. O.; Yoon, J.; Kim, K. K

    2006-12-15

    The concept of a Multi-cavity Cold Gas PressuriZeR(MCGPZR) is applied to the SMART: The pressurizer system includes in-vessel cavities and out-of-vessel gas cylinders holding the gas supply/vent system. The gas cylinders are connected to the one of the in-vessel cavities via piping with valves. A pressurizer is maintained at a cold temperature of less than about 120 .deg. C which is realized with coolers installed in and with wet thermal insulators installed on one of the cavities located inside the hot reactor vessel, to minimize the contribution of a steam partial pressure and is filled with nitrogen gas as a pressure-absorbing medium. The working medium and working temperature of the MCGPZR is totally different from that of a hot steam pressurizer of the commercial PWR. In addition, the MCGPZR is intended to be designed to meet a pressure transient during normal power operation (by its gas volume capacity) without using an active control system and during plant heatup/cooldown operation by using an active gas control (filling/venting) system. Therefore in order to evaluate the feasibility of the concept of the MCGPZR and its intended design goal, the thermal hydraulic behaviors and controllability of the MCGPZR during transients especially a heatup/cooldown operation must be analyzed. In this study, a thermal hydraulic transient analysis computer code, PZRTR rev 1, for the Reactor Coolant System(RCS) of an integral reactor composed of the MCGPZR, modular Once-Through Steam Generators(OTSGs), a core and a reactor coolant loop is developed. The pressurizer module (MCGPZR module) of the PZRTR rev 1 code is based on a two-fluid, nonhomogeneous, nonequilibrium model for the two-phase system behavior and the OTSG module is based on a homogeneous equilibrium model of the two-phase flow process. The core module is simply based on the axial power distributions and the reactor coolant loop is based on the temperature distributions. The code is currently dedicated for the

  7. ποταμοφόρητος (Rev 12 : 15 – from Etymology to Theologoumenon

    Directory of Open Access Journals (Sweden)

    Wiesław Alicki

    2013-06-01

    Full Text Available The paper presents a study on translations of a Greek word ποταμοφόρητος occurring in Rev 12 : 15. The Greek hapax legomenon ποταμοφόρητος is used in Rev 12 : 15. The part of the sentence containing ποταμοφόρητος is translated as: to sweep her away with the current. G. Schneider suggests a correction of the meaning of the word, concentrating on the conjectural purpose of being taken by water (drowning. In order to analyse this issue we begin with the study of etymology of the ποταμοφόρητος. It comes from the noun ποταμός and the adjective φορητός, which is a derivative of φορέω. Composita (compounds formed with φορητός did not refer to any idea of a mortal threat. Till the turn of 19th century ποταμοφόρητος, apart from the Bible, was only certified in the Hesychius’ Lexicon (5th or 6th century. The Egyptian papyri, uncovered and analysed on the turn of the 19th and the 20th century, in which the ποταμοφόρητος is related to the overflows of the Nile, let us doubt Schneider’s proposal, however, still do not solve the problem. The next stage of the research consisted of the analysis of the classical and antique translations of Rev (VL, Vg, Syriac and Coptic translations, as well as Latin and Greek patristic commentaries, which support one of the aforementioned interpretations. The commentators understood the river carrying the Woman as the image of Church persecution and a desire to place the Church under the command of evil forces. One of the versions of the translation of Vetus Latina (type I suggests that the archetype of the water torrent in Rev was the Nile. In the light of classical explanations as to the reasons of the river’s floodings, as well as the parallel in Ezek 29 : 3. 6 we can assume that it was the Nile that served as the archetype of the spewing torrent for the author of the Revelation.

  8. Translesion Synthesis of the N2-2′-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1

    Science.gov (United States)

    2016-01-01

    Translesion synthesis (TLS) of the N2-2′-deoxyguanosine (dG-N2-IQ) adduct of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was investigated in human embryonic kidney 293T cells by replicating plasmid constructs in which the adduct was individually placed at each guanine (G1, G2, or G3) of the NarI sequence (5′-CG1G2CG3CC-3′). TLS efficiency was 38%, 29%, and 25% for the dG-N2-IQ located at G1, G2, and G3, respectively, which suggests that dG-N2-IQ is bypassed more efficiently by one or more DNA polymerases at G1 than at either G2 or G3. TLS efficiency was decreased 8–35% in cells with knockdown of pol η, pol κ, pol ι, pol ζ, or Rev1. Up to 75% reduction in TLS occurred when pol η, pol ζ, and Rev1 were simultaneously knocked down, suggesting that these three polymerases play important roles in dG-N2-IQ bypass. Mutation frequencies (MFs) of dG-N2-IQ at G1, G2, and G3 were 23%, 17%, and 11%, respectively, exhibiting a completely reverse trend of the previously reported MF of the C8-dG adduct of IQ (dG-C8-IQ), which is most mutagenic at G3 ((2015) Nucleic Acids Res.43, 8340−835126220181). The major type of mutation induced by dG-N2-IQ was targeted G → T, as was reported for dG-C8-IQ. In each site, knockdown of pol κ resulted in an increase in MF, whereas MF was reduced when pol η, pol ι, pol ζ, or Rev1 was knocked down. The reduction in MF was most pronounced when pol η, pol ζ, and Rev1 were simultaneously knocked down and especially when the adduct was located at G3, where MF was reduced by 90%. We conclude that pol κ predominantly performs error-free TLS of the dG-N2-IQ adduct, whereas pols η, pol ζ, and Rev1 cooperatively carry out the error-prone TLS. However, in vitro experiments using yeast pol ζ and κ showed that the former was inefficient in full-length primer extension on dG-N2-IQ templates, whereas the latter was efficient in both error-free and error-prone extensions. We believe that the observed differences between

  9. The uvsI gene of Aspergillus nidulans required for UV-mutagenesis encodes a homolog to REV3, a subunit of the DNA polymerase zeta of yeast involved in translesion DNA synthesis.

    Science.gov (United States)

    Han, K Y; Chae, S K; Han, D M

    1998-07-01

    Defects in the uvsI gene of Aspergillus nidulans resulted in high UV sensitivity and reductions of spontaneous and UV-induced reversion of certain alleles, uvsl;uvsA double mutants exhibited high methyl methane sulfonate (MMS)-sensitivity in contrast to the slight sensitivity of the component single mutants. Using such a double mutant as recipient, a clone complementing uvsI501 has been isolated from a chromosome III specific library. The deduced amino acid sequence from the 1.1-kb sequenced region, a part of the 5.2-kb DNA fragment showing uvsI-complementing activity, had a 62% identity with REV3 of yeast. Disruptants of the cloned gene demonstrated the same level of sensitivity to UV light as uvsI and failed to complement uvsI501 in heterozygous diploids.

  10. Pixar y la recepción de sus valores morales en el público infantil : aproximación a la investigación de la audiencia a partir del caso "Del revés"

    OpenAIRE

    Gutiérrez Cardona, Sònia

    2016-01-01

    Aquest treball té l'objectiu d'analitzar la validesa educativa del plantejament de la filmografia de Pixar. El projecte també pretén esbrinar si aquest rigor educatiu s'adapta als espectadors infantils de Pixar. L'objecte d'estudi de la investigació és la recepció de valors en les pel·lícules de la productora cinematogràfica a partir del cas "Del revés". L'anàlisi de valors s'ha realitzat a una mostra de públic infantil de 45 subjectes, aplicant un Test de presència de valors, ideat i creat p...

  11. Reclassification of Flexibacter tractuosus (Lewin 1969) Leadbetter 1974 and 'Microscilla sericea' Lewin 1969 in the genus Marivirga gen. nov. as Marivirga tractuosa comb. nov. and Marivirga sericea nom. rev., comb. nov.

    Science.gov (United States)

    Nedashkovskaya, Olga I; Vancanneyt, Marc; Kim, Seung Bum; Bae, Kyung Sook

    2010-08-01

    The taxonomic position of the misclassified strains [Flexibacter] tractuosus KCTC 2958T and '[Microscilla] sericea' LMG 13021 was studied using a polyphasic approach. The two strains shared 99.1% 16S rRNA gene sequence similarity and 28% DNA-DNA relatedness. On the basis of the phylogenetic evidence supported by genotypic and phenotypic data [Flexibacter] tractuosus KCTC 2958T and '[Microscilla] sericea' LMG 13021 are classified as two distinct species in a novel genus, Marivirga, in the family 'Flammeovirgaceae', as Marivirga tractuosa comb. nov. and Marivirga sericea nom. rev., comb. nov., with strains KCTC 2958T (=ATCC 23168T =CIP 106410T =DSM 4126T =NBRC 15989T =NCIMB 1408T =VKM B-1430T) and LMG 13021T (=ATCC 23182T =NBRC 15983T =NCIMB 1403T), respectively, as the type strains. The type species is Marivirga tractuosa.

  12. PERCEPTIONS OF ORGANIZATIONAL JUSTICE WHICH TEACHERS EMPLOYED IN PRIVATE TEACHING CENTER ÖZEL DERSHANELERDE GÖREV YAPAN ÖĞRETMENLERİN ÖRGÜTSEL ADALET ALGILARI

    Directory of Open Access Journals (Sweden)

    Mustafa YAVUZ

    2012-06-01

    Full Text Available The purpose of this study is to determine the variables that predict perceptions of organizational justice which teachers employed in private teaching center (private institutions preparing students for university entrance examinations have and identify the relationship between perceptions of organizational justice which employees have and their demographic characteristics. The study is of general survey model. The population of the study consists of teachers employed in private teaching center in the Central Anatolia Region in 2008-2009 academic year. The study sample, on the other hand, includes 404 randomly selected teachers who are employed in private teaching center in the provinces of Ankara, Konya, Aksaray, Kayseri and Nevşehir. The research findingsindicate that variables of social security and job security are predictors of employees’ perceptions of organizational justice. Bu araştırmanın amacı, özel dershanelerde görev yapan öğretmenlerin örgütsel adalet algılamalarını yordayan değişkenlerin tespit edilmesi ve çalışanların örgütsel adalet algılamaları ile demografik özellikleri arasındaki ilişkiyi belirlemektir. Araştırma genel tarama modelindedir. Araştırmanın evrenini İç Anadolu bölgesindeki dershanelerde çalışan öğretmenler oluşturmaktadır. Araştırmanın örneklemi ise; tesadüfi örnekleme yöntemiyle seçilen Ankara, Konya, Aksaray, Kayseri ve Nevşehir illerindeki dershanelerde görev yapan 404 öğretmenden oluşmaktadır. Araştırmanın bulguları, sosyal güvenlik ve iş güvencesi değişkenlerinin çalışanların örgütsel adalet algılamalarının yordayıcısı olduğunu göstermektedir.

  13. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Scientific Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular......, the Panel was requested to evaluate 12 flavouring substances in the Flavouring Group Evaluation 11, Revision 2 (FGE.11Rev2), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 12 flavouring substances belong to chemical group 10, Annex I of the Commission Regulation (EC...... is a tertiary alcohol) [FL-no: 07.097, 07.165 and 07.184] all belonging to chemical groups 8 and 10. One of the 12 candidate substances possesses four chiral centres [FL-no: 06.134] two possesses two chiral centres [FL-no: 02.133 and 07.168] and four substances possesses one chiral centre [FL-no: 07.097, 07...

  14. The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.

    Science.gov (United States)

    Breslin, Claire; Mani, Rajam S; Fanta, Mesfin; Hoch, Nicolas; Weinfeld, Michael; Caldecott, Keith W

    2017-09-29

    The scaffold protein X-ray repair cross-complementing 1 (XRCC1) interacts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) and is important for genetic integrity and normal neurological function. One of the most important interactions of XRCC1 is that with polynucleotide kinase/phosphatase (PNKP), a dual-function DNA kinase/phosphatase that processes damaged DNA termini and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-onset seizures and developmental delay (MCSZ). XRCC1 and PNKP interact via a high-affinity phosphorylation-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP. Here, we identified using biochemical and biophysical approaches a second PNKP interaction site in XRCC1 that binds PNKP with lower affinity and independently of XRCC1 phosphorylation. However, this interaction nevertheless stimulated PNKP activity and promoted SSBR and cell survival. The low-affinity interaction site required the highly conserved Rev1-interacting region (RIR) motif in XRCC1 and included three critical and evolutionarily invariant phenylalanine residues. We propose a bipartite interaction model in which the previously identified high-affinity interaction acts as a molecular tether, holding XRCC1 and PNKP together and thereby promoting the low-affinity interaction identified here, which then stimulates PNKP directly. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Energy from agricultural animal wastes. Rev. ed.

    International Nuclear Information System (INIS)

    1994-12-01

    This technology status report discusses the production of animal wastes in the UK, and the environmental problems caused by direct use of the waste as fertilisers or disposal by landfilling. The effects of the moisture content of the waste on the choice of technology is examined, and the use of anaerobic digestion for wetter wastes to produce biogas and combustion of dryer wastes to produce heat, power and phosphate- and potash-rich ash are discussed. Market opportunities, and the economics and environmental impacts of both technologies are investigated

  16. ENDF/B-5 Actinides (Rev. 86)

    International Nuclear Information System (INIS)

    Lemmel, H.D.

    1986-05-01

    This document summarizes the contents of the Actinides part of the ENDF/B-5 nuclear data library released by the US National Nuclear Data Center. This library or selective retrievals of it, are available costfree from the IAEA Nuclear Data Section upon request. The present version of the library is the Revision of 1986. (author). Refs, figs and tabs

  17. Facts on nuclear power. 4. rev. ed.

    International Nuclear Information System (INIS)

    1987-06-01

    The information booklet summarizes physical principles and other fundamental background information relating to nuclear power. The material is subdivided into various brief chapters with tables and illustrations discussing aspects such as: Basic terms and data, energy demand and supply, economics, nuclear power plants in operation, radiation protection, reactor safety, and nuclear waste management. A brief outline of the history of nuclear power in the FRG is given, and a list of addresses and literature for further reading. (UA) [de

  18. Instructor Revs Up Ailing Motorcycle Program

    Science.gov (United States)

    Stevenson, Roy

    2011-01-01

    Bob Monroig smiles every day on his way to work at Lake Washington Technical College (LWTC), high atop a hill overlooking the affluent Seattle suburb of Kirkland, Washington. He's created his own job within a job, where he's the Harley-Davidson University program coordinator and tenured faculty in the Motorcycle, Marine, & Power Equipment…

  19. The First Reactor, 40th Anniversary (rev.)

    Energy Technology Data Exchange (ETDEWEB)

    Allardice, Corbin; Trapnell, Edward R; Fermi, Enrico; Fermi, Laura; Williams, Robert C

    1982-12-01

    This booklet, an updated version of the original booklet describing the first nuclear reactor, was written in honor of the 40th anniversary of the first reactor or "pile". It is based on firsthand accounts told to Corbin Allardice and Edward R. Trapnell, and includes recollections of Enrico and Laura Fermi.

  20. Transesophageal echocardiography. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Lambertz, Heinz; Lethen, Harald

    2013-01-01

    The book on transesophageal echocardiography covers the following issues: Development of transesophageal echocardiography, technical advances; indications and contraindication for transesophageal echocardiography; systematic of the medical examination process; cardiac valves and valve prostheses; mitral and aortic valvuloplasty, TAVI and interventional treatment of mitral regurgitation; infectious endocarditis; one-way and effluence disturbances of the left and right ventricle; diseases of the thoracic aorta; undefined right ventricle enlargement; lung embolism, acute infarct complications; TEE during anesthesia and perioperative intensive medicine, cardiac sources of embolism; cardiac tumors, mediastinal lymph nodes; pericardiac diseases; congenital heart diseases in childhood and adulthood; catheter interventions and heart valve reconstruction; surgically corrected congenital cardiac defects; intracavitary versus transesophageal echocardiography; three-dimensional TEE; coronary diagnostics; ischemia and vitality diagnostics.

  1. Imaging pelvic floor disorders. 2. rev. ed.

    International Nuclear Information System (INIS)

    Stoker, Jaap; Taylor, Stuart A.; DeLancey, John O.L.

    2008-01-01

    This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

  2. Detectors for particle radiation. 2. rev. ed.

    International Nuclear Information System (INIS)

    Kleinknecht, K.

    1987-01-01

    This book is a description of the set-up and mode of action of detectors for charged particles and gamma radiation for students of physics, as well as for experimental physicists and engineers in research and industry: Ionization chamber, proportional counter, semiconductor counter; proportional chamber, drift chamber, bubble chamber, spark chamber, photomultiplier, laser ionization, silicion strip detector; Cherenkov counter, transition radiation detector; electron-photon-cascade counter, hadron calorimeter; magnetic spectrometer; applications in nuclear medicine, geophysics, space travel, atom physics, nuclear physics, and high-energy physics. With 149 figs., 20 tabs [de

  3. Occupational safety manual. 4. rev. ed.

    International Nuclear Information System (INIS)

    Skiba, R.

    1979-01-01

    With the rapid technical development and increasing life expectancy, protection against occupational hazards has become a central economic and social problem. Consultants and others responsible for occupational safety should not only be interested in their work but also have sufficient basic knowledge. The complex subject is presented in a simplified and easily comprehensible manner, with particular regard to the practical side. The book is at the same time a textbook for basic training and a reference manual for the working practice. (orig./HP) [de

  4. Environmental economics. 4. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Wicke, L.

    1993-01-01

    This textbook is intended to reveal and explain the most important issues in environmental economics, a) on the basis of a systematic breakdown of the whole field of environmental economics, and b) with the aid of numerous examples taken from practical environmental policy. The material presented in this book has been grouped according to various subjects as, e.g., instruments of environmental policy, effects of pollution control measures on the economy, etc. The conclusions drawn by the author as a result of his study can be summarized in the following general statement: Democratic states with a free economic system corresponding to the social market economy of the FRG for instance are well endowed with the prerequisites for successfully tackling environmental problems, both in terms of financial and regulatory policy- and experience has already shown that the approach adopted is a practicable and promising one. However, there could be much more success along this line of the political instruments were given greater impetas and impact, and if the regulatory instruments were designed so as to gain more effectiveness. (orig.) [de

  5. Thermodynamics and statistical physics. 2. rev. ed.

    International Nuclear Information System (INIS)

    Schnakenberg, J.

    2002-01-01

    This textbook covers tthe following topics: Thermodynamic systems and equilibrium, irreversible thermodynamics, thermodynamic potentials, stability, thermodynamic processes, ideal systems, real gases and phase transformations, magnetic systems and Landau model, low temperature thermodynamics, canonical ensembles, statistical theory, quantum statistics, fermions and bosons, kinetic theory, Bose-Einstein condensation, photon gas

  6. Radiology of the pancreas. 2. rev. ed.

    International Nuclear Information System (INIS)

    Baert, A.L.; Van Hoe, L.; Delorme, G.

    1999-01-01

    Radiology of the Pancreas discusses the diagnostic role of the various imaging modalities currently available for the assessment of pancreatic anatomy and disease. In comparison with the first edition, new technical developments (helical CT, ultrafast magnetic resonance imaging, color Doppler ultrasound, laparoscopic ultrasound), have been included, and several chapters have been significantly expanded. With the aid of numerous illustrations, the normal radiological anatomy, anatomical variants, the typical and atypical radiological features of both common and uncommon diseases, and potential pitfalls are considered in depth. All of the chapters have been written by recognized experts in the field, and the book should be of value to all radiologists and other specialists who treat patients with pancreatic disease or who have an interest in the subject. (orig.)

  7. Nuclear Security: Target Analysis-rev

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Surinder Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gibbs, Philip W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bultz, Garl A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-03-01

    The objectives of this presentation are to understand target identification, including roll-up and protracted theft; evaluate target identification in the SNRI; recognize the target characteristics and consequence levels; and understand graded safeguards.

  8. Project Execution Plan,Rev. 3; FINAL

    International Nuclear Information System (INIS)

    IT Corporation, Las Vegas

    2002-01-01

    This plan addresses project activities encompassed by the U.S. Department of Energy's (DOE's), National Nuclear Security Administration Nevada Operations Office, Environmental Restoration Division and conforms to the requirements contained in the Life-Cycle Asset Management, DOE Order 430.1A; The Joint Program Office Policy on Project Management in Support of DOE Order 430.1; Program and Project Management for the Acquisition of Capital Assets, DOE Order 413.3; the Project Execution and Engineering Management Planning Guide, GPG-FM-010; and other applicable Good Practice Guides; and the FY 2001 Integrated Planning, Accountability, and Budgeting System Policy Guidance. The plan also reflects the milestone philosophies of the Federal Facility Agreement and Consent Order, as agreed to by the State of Nevada, the DOE, and the U.S. Department of Defense; and traditional project management philosophies such as the development of life-cycle costs, schedules, and work scope; identification o f roles and responsibilities; and baseline management and controls

  9. Boundless energy. 2. rev. ed.; Grenzenlose Energie

    Energy Technology Data Exchange (ETDEWEB)

    Haege, Walter

    2007-07-01

    For thousands of years, all cultures of man have described and researched life energy, whether they called it Qi, Chi, Prana, Od or Orgon. Since Rupert Sheldrake published his theory of morphogenetic fields, the subject has been accessible to the population in general and is contributing to the decline of the current paradigm of science. Knowledge that seamed indisputable since the time of Newton and Descartes is waning, and science must restructure itself on quite a different basis. Einstein, too, is becoming history. The book spans the discoveries of Lord Kelvin to Nikola Tesla to Prof. Dr.-Ing. K. Meyl whose potential eddy theory leads to a new understanding of the world. The key to this is the neutrino, and the fundamentals of neutrino physics are quite simple: At every moment, more than 60 thousand millions of neutrinos flow through us, controlling everything that exists. In his book, author Walter Haege shows how we can all utilise this indispensable neutrino power. It is a book for everyday practice, an indispensable reference manual for all those who intend a radical change in their view of the world and their way of living. (orig.) [German] Seit Jahrtausenden wird in allen Kulturen jene Energie beschrieben und erforscht, die uns steuert und unsere Zeit am Leben erhaelt, jene Energie mit den vielen Namen, von denen uns die bekanntesten, Qi, Chi, Prana, Od oder Orgon vielleicht gelaeufig sind. Seit Rupert Sheldrake und seiner wieder aufgegriffenen Theorie vom morphogenetischen Feld ist dieses Thema grossen Bevoelkerungskreisen neu zugaenglich geworden und traegt dazu bei, dass das jetzige Paradigma der Wissenschaften seinem Ende zugeht. Unser gesichertes Wissen, seit Newton und Descartes scheinbar unumstoesslich, geht dahin und die Wissenschaft muss sich auf gaenzlich anderer Grundlage neu formieren. Auch Einstein wird Geschichte. Die Wirbelphysik Lord Kelvins fuehrt uns ueber die sensationellen Entdeckungen Nikola Teslas zu dem Physiker Prof. Dr.-Ing. K. Meyl, der uns mit seiner Theorie der Potenzialwirbel zu einem neuen Weltverstaendnis fuehrt. Der Schluessel dazu heisst Neutrinos, wobei die Grundlage der Neutrinophysik gaenzlich einfach zu verstehen ist: Mehr als 60 Milliarden Neutrinos pro Sekunde und Quadratzentimeter - aus dem Weltraum kommend - durchfliessen uns und steuern alles was ist. Walter Haege zeigt in diesem Buch praktisch auf, wie jeder von uns diese so notwendige Neutrino-Energie selbst nutzen kann. Es Ist deshalb ein Praxisbuch, dessen Inhalt unverzichtbar fuer jenen Menschen ist, der seine Sicht der Welt und damit sein gesamtes Leben radikal auf neue Fuesse stellen will. (orig.)

  10. Performance appraisal and advancement exercise 2006 (Rev)

    CERN Multimedia

    Human Resources Department

    2005-01-01

    The 2006 performance appraisal and advancement exercise will start in the usual way with annual interviews between staff and their supervisors. This year, these interviews should be held in the period from 1 December 2005 to 15 March 2006*. In this connection, a number of improvements to the procedures relating to the interviews and performance appraisals are currently under study. Administrative Circular No. 26 (Procedures Governing the Career Development of Staff Members) and the electronic MAPS form in EDH are being reviewed and will be available from December onwards. In the meantime supervisors can start the interview procedure. HR Department will shortly provide further information on this subject. The 2005 MAPS report can be retrieved for consultation at any time via EDH. * Instead of 31 March, as indicated in the electronic Bulletin No. 47 of 21 November 2005 Human Resources Department Tel. 73566

  11. Traumatological radiodiagnostics. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Birzle, H.; Bergleiter, R.; Kuner, E.H.

    1985-01-01

    Traumatology accounts for a major part of diagnostic radiography. Correct application and assessment of imaging methods when examining freshly injured patients is of paramount importance and requires a good deal of experience. To this end, the book displays more than 1000 individual pictures. A brief text introduces to the peculiarities of the body region concerned. Typical injury mechanisms and available diagnostic methods are demonstrated including their advantages and disadvantages. This is followed by a comprehensive collection of pictures which also contains CT's and sonographs. With 530 figs [de

  12. Pipeline engineering. 8. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Wagner, W.

    2000-01-01

    Apart from calculating the strength of pipeline components planning and design are the most important tasks on the areas of apparatus manufacturing, fluid engineering, process engineering and thermal engineering. It is therefore necessary that the flow diagrams of a plant are clearly understandable and in accordance with the technical rules even in the early stages of planning. This book concentrates on steel pipeline which are not laid underground but of the type used mostly in industrial applications. The pictures and equations provided can be used for the design of pipelines, tables and diagrams are given to facilitate estimation of elasticity, pipeline pressure losses and insulating thicknesses. An overview of the equations is given at the end of the book. Many examples facilitate learning. (orig.) [de

  13. CVD calibration light systems specifications. Rev. 0

    International Nuclear Information System (INIS)

    Mcllwain, A. K.

    1992-04-01

    Two prototype Cerenkov Viewing Device Calibration Light systems for the Mark IV CVD have been fabricated. They consist of a maintenance unit that will be used by the IAEA maintenance staff and a field unit that will be used by IAEA inspectors. More detailed information on the design of the calibration units can be obtained from the document SSP-39 and additional information on the Mark IV CVD can be obtained from the operating manual published as Canadian Safeguards Support Program document CSSP 6. The specifications refer to the prototype units which will be demonstrated to the IAEA in 1992 May. Based upon the feedback from the IAEA, the instruments will be changed in the final production models to provide devices that more closely satisfy the needs of the end users

  14. ASC FY17 Implementation Plan, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, P. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-06-14

    The Stockpile Stewardship Program (SSP) is an integrated technical program for maintaining the safety, surety, and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational capabilities to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources that support annual stockpile assessment and certification, study advanced nuclear weapons design and manufacturing processes, analyze accident scenarios and weapons aging, and provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balance of resources, including technical staff, hardware, simulation software, and computer science solutions.

  15. Harmful effects on plants. 2. rev. ed.

    International Nuclear Information System (INIS)

    Hock, B.; Elstner, E.F.

    1988-01-01

    The book deals with accidentally or purposefully induced harmful effects on plants, i.e. eukariyotes and fungi, with emphasis being placed on chemicals as the main pollutants. After discussing the quantification of damage as a prerequisite for detecting, defining, and possibly preventing, damage to plants by toxic substances in the environment, the second part of the book deals with the harmful effects that are purposefully induced, for example in agriculture or horticulture, by employment of pesticides (herbicides or fungicides). In this context, all aspects of uptake, metabolism, and detoxication are discussed, especially referring to the molecular conditions of relevance to a selective elimination of metabolic or developmental processes in the plants, which is explained by the effects of pesticides and antibiotics. Injuries caused by autogenous substances in the plants, upon exceeding a certain amount or dose are also explained, together with effects of physical factors (as e.g. ionizing radiation), or biogenic factors (as e.g. parasites). (ECB) [de

  16. Horns Rev II, 2-D Model Tests

    DEFF Research Database (Denmark)

    Andersen, Thomas Lykke; Frigaard, Peter

    This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), on behalf of Energy E2 A/S part of DONG Energy A/S, Denmark. The objective of the tests was: to investigate the combined influence of the pile...... diameter to water depth ratio and the wave hight to water depth ratio on wave run-up of piles. The measurements should be used to design access platforms on piles....

  17. Diagnostic nuclear medicine. 2. rev. ed.

    International Nuclear Information System (INIS)

    Schiepers, C.

    2006-01-01

    The field of nuclear medicine is undergoing rapid expansion, and is evolving into diagnostic molecular imaging. During recent years, dual-modality imaging with PET/CT has gained acceptance and this is currently the fastest-growing technique for oncological imaging applications. The glucose analogue FDG has held its place in diagnostic oncology, assessment of myocardial viability and diagnosis of neuro-degenerative disorders. Peptides have become even more important as imaging agents. The accuracy of hepatobiliary scintigraphy has been enhanced by cholecystokinin. The use of ACE inhibitors in the evaluation of renovascular hypertension has become the standard in renography. New instrumentation has led to faster scanners, and computer development to better image processing software. Automatic processing is more common, and standardization of protocols can be accomplished easily. The field of gene imaging has progressed, although routine clinical applications are not yet available. The present text, supplemented with many detailed and informative illustrations, represents an adjunct to the standard knowledge of diagnostic nuclear medicine and provides both the student and the professional with an overview of developments during the past decade. (orig.)

  18. Physics, radiology and chemistry. 6. rev. ed.

    International Nuclear Information System (INIS)

    Linde, O.K.; Knigge, H.J.

    1981-01-01

    The scientific basic disciplines of physics and chemistry are the beginning of all medical teaching. They are suitable to clarify medical and biochemical problems in their causality by means of their own thinking methodics as well as by the information provided. This book attempts to point out the relationships of physics, radiology and chemistry to neighbouring disciplines, especially to practical medicine. Greater importance must naturally be given here to the examples of individual fundamental facts than to the conveying of pure theory from books. The statements and questions on self control ordered according to chapter represent a minimum learning for the students which can be extended as required. (orig./ORU) [de

  19. Radiology. Basic course 2. 4. rev. ed.

    International Nuclear Information System (INIS)

    Heilmann, A.; Steinhorst, M.

    1990-06-01

    The first part presents the subject catalogue in general radiology and a comprehensive refresher course. The main facts most frequently asked in examinations are dealt with in detail. The second part lists all important original questions from the field of general radiology, arranged by the chapters of the subject catalogue. For quick checking, correct answers are shown at the bottom of each page. The commentary presents a summary of examination problems, related subjects and problems, and hints referring to differential diagnostic aspects. The commentary part is followed by a reproduction of the original examination problems presented from March 1988 through August 1989, each collection of problems with a commentary. Students may test their state of knowledge by going through these collections of problems. There also is a collection of original images belonging to the questions. (orig./HP) With 40 figs [de

  20. Physics, radiology, and chemistry. 7. rev. ed.

    International Nuclear Information System (INIS)

    Linde, O.K.; Knigge, H.J.

    1986-01-01

    This book is an introduction to physics and chemistry especially for medical personnel. After a general introduction, measurement methods, mechanics including mechanics of solid bodies, fluids and gases, heat, optics, acoustics, electricity, radiations including their biological effects, general chemistry, inorganic and organic chemistry are treated. Every chapter contains exercises mostly in connection with medical and biological effects. Furthermore, connections with biology and medicine are considered. The chapters on physiological chemistry, computer and information theory, chemistry and ecology, and metabolism have been rewritten. (orig./HP) [de

  1. Industrial inorganic chemistry. 2. rev. ed.

    International Nuclear Information System (INIS)

    Buechner, W.; Schliebs, R.; Winter, G.; Buechel, K.H.

    1986-01-01

    Inorganic chemistry is a branch of considerable economic and technical importance. Apart from supplying the market with metals, fertilizers, building materials, pigments and glass it is one of the major suppliers of process materials to the organic chemical industry. Many modern products of other industrial sectors (video tapes, optical fibers or silicon chips) could not have been developed and manufactured without the achievements of industrial inorganic chemistry. The publication is the first of its kind to give a compact description of the inorganic chemistry sector. A clearly arranged survey facilitates access to production processes, economic aspects, ecological implications, energy consumption and raw material consumption as well as to many other data and facts. Due to its clear arrangement and the combination of technical and economic facts the book is a valuable source of information. (orig./EF) [de

  2. Fundamentals of environmental engineering. 2. rev. ed.

    International Nuclear Information System (INIS)

    Bank, M.

    1994-01-01

    'Fundamentals of Environmental Engineering' contains the technical and legal bases for the force environmental areas water supply and waste water disposal, clean air, waste avoidance and waste disposal, as well as noise protection in compact form. Particular scope was allowed for the description of the linkages between the individual environmental areas - for instance, waste combustion and clean air, waste deposition at landfills and treatment of leachate, residual products from successful water and air pollution control measures. For all those who have to familiarize themselves with the complex subject of 'environmental engineering' while in training or during continuing education this book offers a broad approach to the essential general, technical and legal bases. (orig.) [de

  3. Teaching atlas of mammography. 2. rev. ed.

    International Nuclear Information System (INIS)

    Tabar, L.; Dean, P.B.

    1985-01-01

    The purpose of this Atlas is to teach radiologists how to analyze mammograms and arrive at the correct diagnosis through proper evaluation of the findings. The illustrated cases cover practically the entire spectrum of breast abnormalities. They are based upon referred patient material as well as 80000 mammographic screening examinations. There are two basic steps in the interpretation of mammograms: perception and analysis. Since the greatest benefit of mammography lies in the detection of breast carcinoma in its earliest possible stages, every mammogram must be systematically surveyed for the subtle hints of malignancy. Perception is taught in this Atlas by describing a method for systematic viewing. The reader is then provided with a series of mammograms with obscure lesions to encourage practice with this method. With the help of a coordinate system, the lesions can be precisely located. Practice in perception continues throughout the Atlas. After detecting an abnormality on the mammogram, the diagnosis can be reached through a careful analysis of the X-ray signs. Additional projections, coned-down compression and magnetification views provide further help in this analytic workup. Rather than starting with the diagnosis and demonstrating typical findings, the approach of this Atlas is to teach the reader how to analyze the image and reach the correct diagnosis through proper evaluation of the X-ray signs. Prerequisites for the perception and evaluation of the X-ray signs are optimum technique, knowledge of anatomy and understanding of the pathological processes leading to the mammographic appearances. (orig.)

  4. 2014 SRNL LDRD Annual Report, Rev. 0

    Energy Technology Data Exchange (ETDEWEB)

    Mcwhorter, S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-03-15

    Laboratory Directed Research and Development is a congressionally authorized program that provides the ‘innovation inspiration’ from which many of the Laboratory’s multi-discipline advancements are made in both science and engineering technology. The program is the backbone for insuring that scientific, technical and engineering capabilities can meet current and future needs. It is an important tool in reducing the probability of technological surprise by allowing laboratory technical staff room to innovate and keep abreast of scientific breakthroughs. Drawing from the synergism among the EM and NNSA missions, and work from other federal agencies ensures that LDRD is the key element in maintaining the vitality of SRNL’s technical programs. The LDRD program aims to position the Laboratory for new business in clean energy, national security, nuclear materials management and environmental stewardship by leveraging the unique capabilities of the Laboratory to yield foundational scientific research in core business areas, while aligning with SRS strategic initiatives and maintaining a vision for ultimate DOE applications.

  5. The ecological atlas. 3. rev. ed.

    International Nuclear Information System (INIS)

    Seager, J.

    1993-01-01

    ''The ecological atlas'' translates expert knowledge in a way that makes it accessable to the general public. In 37 double sided maps in four colours it gives information about the health of our planet and the quality of human life. Under 8 different angles: (the earth's habitat, food and drinking water, housing, energy, industry, armament, consumer needs and 'green politics'). ''The ecological atlas'' describes the effects of worldwide ecological effects: climatic disasters, the greenhouse effect, the hole in the ozone layer, destruction of the tropical rainforests, the effects of extensive farming and increasing urbanization. Pages of comprehensive commentaries complement the maps and aid understanding of their problem areas. (orig./DG) [de

  6. Radiology. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Reiser, Maximilian; Kuhn, Fritz-Peter; Debus, Juergen

    2011-01-01

    The text book on radiology covers the following issues: Part A: General radiology: Fundamental physics: radiation biology; radiation protection fundamentals: radiologic methods; radiotherapy; nuclear medicine. Part B: Special radiology: Thorax; heart; urogenital tract and retroperitoneum; vascular system and interventional radiology; esophagus, stomach, small and large intestines; liver, biliary system, pancreas and spleen; mammary glands; central nervous system; spinal cord and spinal canal; basis of the skull, facial bones and eye socket; neck; pediatric imaging diagnostics.

  7. Biological fundamentals. 2. completely rev. ed

    Energy Technology Data Exchange (ETDEWEB)

    Sahm, H. (ed.) (Forschungszentrum Juelich GmbH (Germany). Inst. fuer Biotechnologie)

    1993-01-01

    This fully revised and expanded Second Edition takes into account all recent developments in biotechnology. It is extraordinarily broad in scope, up-to-date, carefully structured and wellbalanced. 'Biotechnology' considers both basic concepts and widely-differing industrial applications: It is a successful synthesis of theory and practice. Any scientist aiming for success in industrial microbiology, biochemistry, molecular biology and chemical engineering must turn to 'Biotechnology'. Everybody involved in biotechnology will appreciate having this volume at their fingertips. It offers a unique collection of current information on the basic biology (ecology, taxonomy, biochemistry, physiology, and genetics) of industrially important organisms. This book contains the background material indispensable for the development of biotechnological processes. Topics included are: - Cell Structure, - Metabolism, - Growth of Microorganisms, - Metabolic Design, - Immobilized Organisms, - Methylotrophs, - Pseudomonas, - Yeasts, - Filamentous Fungi, - Bacteriophages, - Cell Cultures. (orig.)

  8. Pediatric uroradiology. 2nd rev. ed.

    International Nuclear Information System (INIS)

    Fotter, Richard

    2008-01-01

    Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle ''guidelines and beyond,'' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

  9. Pediatric uroradiology. 2nd rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Fotter, Richard (ed.) [Univ. Hospital Medical Univ. Graz (Austria). Div. of Pediatric Radiology

    2008-07-01

    Since the first edition of Pediatric Uroradiology, very significant advances have been made in the imaging and treatment of common and important pediatric urologic disorders such as vesicoureteric reflux, urinary tract infection, and upper urinary tract dilatation. This revised and extended version takes full account of the sometimes dramatic changes. Where appropriate, new contents have been included, e.g., on genetics, while other information that continues to be pertinent has been retained. This book describes in detail all aspects of pediatric uroradiology. While it is written primarily from the point of view of the radiologist, it includes essential information for the pediatrician, pediatric surgeon, and urologist. It is specifically designed to aid the clinician in decisions on imaging management. The newest techniques and the changing relevance of imaging and interventional procedures are presented, and the diverse problems associated with the changing anatomy, physiology, and pathophysiology from the newborn period to adulthood are explained. The whole spectrum of imaging features of agenesis, anomalies, dysplasia, parenchymal diseases, neoplastic diseases, stone disease, renal vascular hypertension, renal failure, renal transplantation, and genitourinary trauma is covered. Individual chapters are devoted to vesicoureteric reflux, urinary tract infection, upper urinary tract dilatation, voiding dysfunction, and neurogenic bladder. A new chapter on the clinical management of common nephrourologic disorders, with the subtitle 'guidelines and beyond,' explains how imaging is embedded in the whole process of clinical management today. Short conclusions are included at the end of chapters and sections to provide the reader with the key information on the specific topic under consideration. (orig.)

  10. Transport of radioactive materials. 2. rev. ed.

    International Nuclear Information System (INIS)

    Vogt, H.W.; Falkhof, W.; Heibach, K.; Ungermann, N.; Hungenberg, H.

    1991-01-01

    With the last changes in the Ordinance Concerning the Transport of Hazardous Goods two regulations which are important for the carrying trade were introduced: 1. The conveyer must train the driver. He must only employ reliable drivers. 2. The driver must participate in a training course (as of July 1, 1991). These obligations, which already existed in the past in regard to the transport of nuclear fuel, have been extended to include the transport of other radioactive materials. In part I the book deals with basic training courses for parcelled goods, and part II goes into the special knowledge which is required of drivers of radioactive materials. The parts consist of the following sections: 1. General regulations, 2, Responsibility when transporting hazardous goods, 3. General danger features, 4. Information on dangers and their designation, 5. The vehicle's equipment and carrying out the transport, 6. Measures for avoiding accidents. At the end of each section the participant in the course finds a series of questions which pertain to the subject matter just treated so that he can test his own learning performance. So as to make things easier for the trainee, the corect answers are listed in the appendix. As a supplementary section on radioactive materials, part II offers additional detailed explanations by experts in the field on the features of radioactive materials and the dangers they pose. In the margin - next to the instructory text - the key words are given so that the right place in the text of the instruction manual can be readily found. These key words are compiled in the appendix to form an index. (orig./HP) [de

  11. Techniques of lipidology. 2. rev. ed.

    International Nuclear Information System (INIS)

    Kates, M.

    1986-01-01

    In this volume basic knowledge and the most reliable and useful methods and experimental procedures are collected for the study of the chemistry and metabolism of lipids. The material presented covers information necessary for the qualitative and quantitative analysis of cellular or tissue lipids, and for identification and structural determination of lipid classes or individual components. (Auth.)

  12. Environmental law. 6. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    1991-01-01

    This pocketbook contains major federal regulation on environmental protection. They serve to protect and cultivate mankind's natural foundations of life, to preserve the environment. The environments law is devided as follows: Constitutional law on the environment. Common administative law on the environment, special administrative law on the environment including conservation of nature and preservation of rural amenities, protection of waters waste management, protection against nuisances, nuclear energy are radiation protection, energy conservation, protection against dangerous substances, private law relating to the environment, criminal law relating to the environment. The transitional provisons required for estaslishing the unified Germany are given in an annex. (orig.) [de

  13. Imaging pelvic floor disorders. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Stoker, Jaap [Amsterdam Univ. (Netherlands). Dept. of Radiology; Taylor, Stuart A. [University College Hospital, London (United Kingdom). Dept. of Specialist X-Ray; DeLancey, John O.L. (eds.) [Michigan Univ., Ann Arbor, MI (United States). L4000 Women' s Hospital

    2008-07-01

    This volume builds on the success of the first edition of imaging pelvic floor disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles. The closing sections of the book describe the modern clinical management of pelvic floor dysfunction, including prolapse, urinary and faecal incontinence and constipation, with specific emphasis on the integration of diagnostic and treatment algorithms. (orig.)

  14. Technical fluid dynamics. 7. rev. ed.

    International Nuclear Information System (INIS)

    Becker, E.; Piltz, E.

    1993-01-01

    An introductory textbook for students of engineering containing the following subjects: Definition and properties of fluids, hydrostatics, Bernoulli's equation, theorem of momentum for steadystate flows, wing lattice and single wing, plane parallel flow of a viscous fluid, pipe flow, boundary layers, gas flows. (orig.) [de

  15. Radiology. 3. rev. and enl. ed.; Radiologie

    Energy Technology Data Exchange (ETDEWEB)

    Reiser, Maximilian [Klinikum der Universitaet Muenchen (Germany). Inst. fuer Klinische Radiologie; Kuhn, Fritz-Peter [Klinikum Kassel (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Debus, Juergen [Radiologische Universitaetsklinik, Heidelberg (Germany). Abt. Radioonkologie und Strahlentherapie

    2011-07-01

    The text book on radiology covers the following issues: Part A: General radiology: Fundamental physics: radiation biology; radiation protection fundamentals: radiologic methods; radiotherapy; nuclear medicine. Part B: Special radiology: Thorax; heart; urogenital tract and retroperitoneum; vascular system and interventional radiology; esophagus, stomach, small and large intestines; liver, biliary system, pancreas and spleen; mammary glands; central nervous system; spinal cord and spinal canal; basis of the skull, facial bones and eye socket; neck; pediatric imaging diagnostics.

  16. Operating Manual of Helium Refrigerator (Rev. 2)

    Energy Technology Data Exchange (ETDEWEB)

    Song, K.M.; Son, S.H.; Kim, K.S.; Lee, S.K.; Kim, M.S. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    A helium refrigerator was installed as a supplier of 20K cold helium to the cryogenic distillation system of WTRF pilot plant. The operating procedures of the helium refrigerator, helium compressor and auxiliary apparatus are described for the safety and efficient operation in this manual. The function of the helium refrigerator is to remove the impurities from the compressed helium of about 250psig, to cool down the helium from ambient temperature to 20K through the heat exchanger and expansion engine and to transfer the cold helium to the cryogenic distillation system. For the smoothly operation of helium refrigerator, the preparation, the start-up, the cool-down and the shut-down of the helium refrigerator are described in this operating manual. (author). 3 refs., 14 tabs.

  17. GGVS. 7. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Ridder, K.

    1991-01-01

    The brochure contains the following texts: (1) Ordinance on road transport of hazardous materials (GGVS), including the European agreement on international road transport of hazardous materials (ADR), as of 1991: Skeleton ordinance, annexes A and B, reasons given for the first version, and for the first amendment in 1988, execution guidelines - RS 002 (guidelines for executing the ordinance on road transport of hazardous materials, with catalogue of penalties), guidelines for drawing up written instructions for the event of accidents - RS 006, guiding principles for the training of vehicle conductors; (2) ordinance regarding exceptions from the ordinance on road transport of hazardous materials; (3) ordinance regarding exceptions from the ordinance on rail transport of hazardous materials; (4) selected guidelines: Technical guidelines TR IBC K 001, TR IBL 002 - TRS 003, - TRS 004, - TRS 005, - TRS 006; (5) listing of materials and objects governed by the ordinance on hazardous materials transport; (6) catalogue of penalties relative to road transport of hazardous materials. (orig.) [de

  18. Radioactivity: Risks - safety. 2. rev. ed.

    International Nuclear Information System (INIS)

    Grupe, H.

    1991-01-01

    This revised and updated version of the report first published in 1987 by Karlsruhe Nuclear Center has been prepared by scientists of the Center who are experts in nuclear science and technology. The idea was to fulfill the so-to-speak ''creditor's'' obligation in the public debate about nuclear energy and its hazards, and to provide the general public not so familiar with the subject matter with information and insight for better understanding, hoping that the general public on their part will fulfill their ''debtor's'' obligation by trying to get properly informed. Chapters 1 and 6 of the report have been revised and brought up to date, while chapter 3 has been fully re-written, taking as a main source of reference the 1989 publication of Phase B of the German Risk Study on nuclear power plant. Chapters 2 and 5 are new in this report, dealing with less broadly known applications of radioactive substances in science, medicine and technology, and with the radiological situation in Germany after the Chernobyl reactor accident. (orig./DG) [de

  19. Reference Model 2: "Rev 0" Rotor Design

    Energy Technology Data Exchange (ETDEWEB)

    Barone, Matthew F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Berg, Jonathan Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Griffith, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2011-12-01

    The preliminary design for a three-bladed cross-flow rotor for a reference marine hydrokinetic turbine is presented. A rotor performance design code is described, along with modifications to the code to allow prediction of blade support strut drag as well as interference between two counter-rotating rotors. The rotor is designed to operate in a reference site corresponding to a riverine environment. Basic rotor performance and rigid-body loads calculations are performed to size the rotor elements and select the operating speed range. The preliminary design is verified with a simple finite element model that provides estimates of bending stresses during operation. A concept for joining the blades and support struts is developed and analyzed with a separate finite element analysis. Rotor mass, production costs, and annual energy capture are estimated in order to allow calculations of system cost-of-energy. Evaluation Only. Created with Aspose.Pdf.Kit. Copyright 2002-2011 Aspose Pty Ltd Evaluation Only. Created with Aspose.Pdf.Kit. Copyright 2002-2011 Aspose Pty Ltd

  20. Lungs, pleura, thoracal wall. 7. rev. ed.

    International Nuclear Information System (INIS)

    Stender, H.S.

    1988-01-01

    The book describes the anatomy of the lungs, as well as X-ray, computerized tomography, nuclear magnetic resonance, and nuclear-medical imaging techniques. Following a discussion of the general symptomatology of pulmonary diseases verifiable by X-ray, the individual diseases including inhalation damage from inorganic dusts and gases are dealt with. Traumatic thoracal conditions, the image of the thorax after operations, alterations of the thoracal wall, as well as pleural diseases are also discussed. (MG) With 1776 figs., 52 tabs [de

  1. Radiation monitoring: an introduction. Rev. ed.

    International Nuclear Information System (INIS)

    Hayward, P.; Arnott, D.

    1987-01-01

    This Greenpeace pamphlet has been produced in reponse to requests from members of the public wishing to set up monitoring groups. It lists some U.K. manufacturers of radiation monitoring equipment and the contributors have summarized information available from manufacturer's own catalogues describing the equipment, what it will and will not do and costing various programmes. Three types of monitoring are discussed: monitoring the level of background gamma radiation, monitoring radioactive contamination, (early warning systems), and monitoring food and environmental samples for very low levels of radiation. (UK)

  2. FINAL REPORT MELTER TESTS WITH AZ-101 HLW SIMULANT USING A DURAMELTER 100 VITRIFICATION SYSTEM VSL-01R10N0-1 REV 1 2/25/02

    Energy Technology Data Exchange (ETDEWEB)

    KRUGER AA; MATLACK KS; KOT WK; PEGG IL

    2011-12-29

    heat transfer in rate attainment and the much greater role of wall effects in heat transfer when the melt pool is not agitated. The DM100 melter used for the present tests has a surface area of 0.108 m{sup 2}, which is approximately 5 times larger than that of the DM10 (0.021 m{sup 2}) and approximately 11 times smaller than that of the DM1000 (1.2 m{sup 2}) (the DM1000 has since been replaced by a pilot-scale prototypical HLW melter, designated the DM1200, which has the same surface area as the DM1000). Testing on smaller melters is the most economical method for obtaining data over a wide range of operating conditions (particularly at extremes) and for guiding the more expensive tests that are performed at pilot-scale. Thus, one objective of these tests was to determine whether the DM100 melters are sufficiently large to reproduce the un-bubbled melt rates observed at the DM1000 scale, or to determine the extent of any off-set. DM100-scale tests can then be used to screen feed chemistry variations that may serve to increase the un-bubbled production rates prior to confirmation at pilot scale. Finally, extensive characterization data obtained on simulated HLW melter feeds formed from various glass forming additives indicated that there may be advantages in terms of feed rheology and stability to the replacement of some of the hydroxides by carbonates. A further objective of the present tests was therefore to identify any deleterious processing effects of such a change before adopting the carbonate feed as the baseline. Data from the WVDP melter using acidified (nitrated) feeds, and without bubbling, showed productions rates that are higher than those observed with the alkaline RPP feeds at the VSL. Therefore, the effect of feed acidification on production rate also was investigated. This work was performed under Test Specification, 'TSP-W375-00-00019, Rev 0, 'HLW-DM10 and DM100 Melter Tests' dated November 13, 2000 and the corresponding Test Plan. It

  3. EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF); Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The European Food Safety Authority (EFSA) asked the Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs...... in the Member States. In particular, the Panel was requested to evaluate 19 flavouring substances in the Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. These 19 flavouring substances belong to chemical groups 15, 16, 22......-no: 03.022] Industry has informed that it occurs as a mixture of E- & Z-isomers, however, the composition of the mixture has to be specified. Two of the flavouring substances are classified into structural class I, seven are classified into structural class II and 10 are classified into structural class...

  4. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 12, Revision 4 (FGE.12Rev4): primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters from chemical groups 1 and 7

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Frandsen, Henrik Lauritz

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 12 flavouring substances in Flavouring Group Evaluation 12, Revision 4 (FGE.12Rev4), including two additional substances, using the Procedure in Commission...... (the Procedure) that integrates information on structure–activity relationships, intake from current uses and the toxicological threshold of concern and available data on metabolism and toxicity. The Panel concluded that none of the 12 substances [FL-nos: 02.134, 02.186, 02.216, 02.217, 05.157, 05.......182, 05.183, 05.198, 08.135, 09.342, 09.670 and 09.829] gives rise to safety concerns at their levels of dietary intake, estimated on the basis of the maximised survey-derived daily intake approach. Besides the safety assessment of these flavouring substances, the specifications for the materials...

  5. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 73, Revision 3 (FGE.73Rev3): Consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Frandsen, Henrik Lauritz; Nørby, Karin Kristiane

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further...... of one additional substance, beta-ionyl acetate [FL-no: 09.305] cleared for genotoxicity concern in FGE.213Rev1. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern.......712] considered in this FGE and agrees with the JECFA conclusion, “No safety concern at estimated levels of intake as flavouring substances” based on the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered...

  6. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 3, Revision 2 (FGE.03Rev2): Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated or unsaturated

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate one flavouring substance, acetaldehyde ethyl isopropyl acetal [FL-no: 06.137], structurally related to the 58 flavouring substances in the Flavouring Group...... on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded as for the other already evaluated substances that the substance [FL-no: 06.137] do not give rise to safety concern at its level of dietary...... intake, estimated on the basis of the MSDI approach. Besides the safety assessment of this flavouring substance, the specifications for the materials of commerce have also been considered, and since the publication of FGE.03Rev1 additional information on chirality on 30 substances is made available...

  7. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 220, Revision 1 (FGE.220Rev1): alpha,beta-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister

    in the Member States. In particular, the Panel was asked to evaluate flavouring substances using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. The present revision of FGE.220, FGE.220Rev1, concerns the evaluation of additional data submitted by Industry in response...... was alleviated, since one of the substances, for which positive genotoxicity data in mice were obtained, was not carcinogenic in a valid chronic assay in rats. Therefore, no further genotoxicity tests in somatic cells were required. However, some evidence was also available that this substance might elicit...... was requested. In March 2009 the Flavouring Industry submitted new data in reply to the above requested data for subgroup 4.4b of FGE.220. These data have now been examined by the Panel which has concluded the following. The results of a valid rat fertility and dominant lethal study have shown...

  8. ارزیابی پروسه پایداری واکسن بروسلا ملی تنسیس Rev.1درایران

    Directory of Open Access Journals (Sweden)

    ا. پوراحمدی

    2009-07-01

    Full Text Available واکسن Rev.1 از جمله بهترین و با ارزش‌ترین واکسن‌های موجود برای پیشگیری و کنترل بروسلوز گوسفند و بز می‌باشد که توسط سازمان‌های معتبر بین‌المللی از جمله WHOو OIE و FAO به رسمیت شناخته شده است. مؤثر بودن این واکسن توسط محققین کشور و با همکاری سازمان بهداشت جهانی در شرایط اقلیمی ایران بر روی نژادهای گوسفند و بز ایرانی به اثبات رسیده است. بطوریکه از سال 1341 که تولید واکسن و واکسیناسیون Rev.1 در کشور آغاز شده, میزان شیوع بیماری از میزان 45% به 8/1% تقلیل یافته است. طبق منابع رسمی WHO پایداری واکسن Rev.1بیش از یکسال می‌باشد، در حالیکه تاریخ انقضاء واکسنهای تولیدی Rev.1 کشور سه الی چهار ماه است، لذا افزایش زمان پایداری واکسن می‌تواند بسیاری از مشکلات بخش تولید را حل کند و درخواست سازمان دامپزشکی که افزایش مدت نگهداری واکسن است، پاسخ مثبت دهد. این مطالعه با شاخص قرار دادن و ارزیابی ماده نگهدارنده و روش لیوفیلیزاسیون افزایش مدت نگهداری واکسن بود. نوع ماده نگهدارنده در دو حجم متفاوت و همچنین سه روش مختلف لیوفیلیزاسیون که در افزایش زمان نگهداری موثر بود، تهیه و مورد ارزیابی قرار گرفت. از یافته‌های این تحقیق آنکه بهترین ترکیب ماده نگهدارنده برای واکسن Rev.1 شامل : باکتوکازیتون 5/2%، ساکارز 5% و ال گلوتامیک اسید 5

  9. Neurology check list. 5. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Grehl, Holger; Reinhardt, Frank

    2013-01-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  10. Quantum physics for dummies. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Holzner, Steven

    2012-01-01

    Quantum physics is a central and fascinating, albeit unpopular by many students theme of physics. Steven Holzner explains understandably and alively, what must be known about quantum physics. He explains the foundations of angular momentum and spin, gives tips how complex equations can be solved. Thereby he works with examples, which he explains extensively.

  11. Quantum mechanics. Introduction. 6. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Greiner, W.

    2005-01-01

    The following topics are dealt with: Quantization of physical quantities, radiation laws, the wave aspect of matter, mathematical foundations of quantum mechanics, ther Schroedinger equation, the harmonic oscillator, the transition from classical to quantum mechanics, a charged particle in the electromagnetic field, the hydrogen atom, perturbation theory and approximation procedures, spin, a nonrelativistic wave equation with spin, systems of identical particles, the formal scheme of quantum mechanics, conceptions and philosophical problems of quantum mechanics. (HSI)

  12. Quantum mechanics. Textbook on theoretical physics III. 4. rev. ed.

    International Nuclear Information System (INIS)

    Fliessbach, T.

    2005-01-01

    This textbook present an intoduction to quantum mechanics, as it is offerred at the university in the cycle ''Theoretical Physics''. Special value has the author put on a well readable, understandable, and surveyable representation, so that the reader it can reproduce without larger difficulties. By the partition into chapters, which form separated course units, and the kind of the representation the book is also suited for bachelor curricula. The quantum mechanics are first introduced in the form of Schroedinge's wave mechanics. The fundamental relations of quantum mechanics and their interpretation are thereby explained by means of examples and first applications. In the following chapters the most important applications of the Schroedinger equation are studied, like the alpha decay, the scattering of a particle on a potential, and the hydrogen atom. Thereafter the abstract formulation of quantum mechanics (Hilbert space) is introduced in analogy to the known structure of the vector space. This formulation is then applied to concrete problems like the oscillator, tha angular momentum, and the spin. The most important approximation methods of quantum mechanics are then summarized. In the concluding part about many-particle systems the ideal Fermi gas is treated; simple applications of this model in atomic, solid-state, nuclear, ans astrophysics are discussed

  13. Radiometic methods in geologic age determination. 2. rev. ed.

    International Nuclear Information System (INIS)

    Wendt, I.; Schoell, M.

    1986-01-01

    This book is to furnish geoscientists with an overview of the common methods of radiometric age determination, their bases and spheres of application. The first chapters outline the theoretical basis of the procedure in readily understandable form. This presentation omits complicated mathematical derivations in favour of illustrative graphs. The application of the different methods and interpretation of the results are discussed with reference to practical examples. (orig./PW) [de

  14. Oak Ridge National Laboratory Waste Management Plan. Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    1991-12-01

    The goal of the Oak Ridge National Laboratory (ORNL) Waste Management Program is the protection of workers, the public, and the environment. A vital aspect of this goal is to comply with all applicable state, federal, and DOE requirements. Waste management requirements for DOE radioactive wastes are detailed in DOE Order 5820.2A, and the ORNL Waste Management Program encompasses all elements of this order. The requirements of this DOE order and other appropriate DOE orders, along with applicable Tennessee Department of Environment and Conservation (TDEC) and US Environmental Protection Agency (EPA) rules and regulations, provide the principal source of regulatory guidance for waste management operations at ORNL. The objective of the Oak Ridge National Laboratory Waste Management Plan is to compile and to consolidate information annually on how the ORNL Waste Management is to compile and to consolidate information annually on how the ORNL Waste Management Program is conducted, which waste management facilities are being used to manage wastes, what forces are acting to change current waste management systems, what activities are planned for the forthcoming fiscal year (FY), and how all of the activities are documented.

  15. Specification of advanced safety modeling requirements (Rev. 0).

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H.; Tautges, T. J.

    2008-06-30

    The U.S. Department of Energy's Global Nuclear Energy Partnership has lead to renewed interest in liquid-metal-cooled fast reactors for the purpose of closing the nuclear fuel cycle and making more efficient use of future repository capacity. However, the U.S. has not designed or constructed a fast reactor in nearly 30 years. Accurate, high-fidelity, whole-plant dynamics safety simulations will play a crucial role by providing confidence that component and system designs will satisfy established design limits and safety margins under a wide variety of operational, design basis, and beyond design basis transient conditions. Current modeling capabilities for fast reactor safety analyses have resulted from several hundred person-years of code development effort supported by experimental validation. The broad spectrum of mechanistic and phenomenological models that have been developed represent an enormous amount of institutional knowledge that needs to be maintained. Complicating this, the existing code architectures for safety modeling evolved from programming practices of the 1970s. This has lead to monolithic applications with interdependent data models which require significant knowledge of the complexities of the entire code in order for each component to be maintained. In order to develop an advanced fast reactor safety modeling capability, the limitations of the existing code architecture must be overcome while preserving the capabilities that already exist. To accomplish this, a set of advanced safety modeling requirements is defined, based on modern programming practices, that focuses on modular development within a flexible coupling framework. An approach for integrating the existing capabilities of the SAS4A/SASSYS-1 fast reactor safety analysis code into the SHARP framework is provided in order to preserve existing capabilities while providing a smooth transition to advanced modeling capabilities. In doing this, the advanced fast reactor safety models will target leadership-class computing architectures for massively-parallel high-fidelity computations while providing continued support for rapid prototyping using modest fidelity computations on multiple-core desktop platforms.

  16. 16oct AM poster prog rev.pmd

    Indian Academy of Sciences (India)

    Administrator

    1530 T V Ramakrishnan. T V Ramakrishnan. T V Ramakrishnan, BHU, Varanasi. Walter Kohn and the rise of condensed matter physics. 1600 Swapan K Ghosh. Swapan K Ghosh. Swapan K Ghosh, BARC, Mumbai. Density functional theory for materials modeling at different length scales: A legacy of Walter Kohn.

  17. The effects of nuclear war. 2. rev. enl. ed.

    International Nuclear Information System (INIS)

    Rodejohann, J.

    1982-01-01

    Possible and probable effects of a nuclear war in Europe are described on the basis of a study by the Office of Technology Assessment, US Kongress ('The effects of nuclear war', Wash. D.C. 1979). (HP) [de

  18. Verification of failure avoidance concepts in R6 Rev3

    International Nuclear Information System (INIS)

    Milne, I.; Knee, N.

    1988-09-01

    The first part of this Report outlines how recent developments in fracture mechanics have led to a more accurate interpretation of the two-criteria approach to defect assessment. The implementation of these developments into Revision 3 of the Central Electricity Generating Board code of practice for the assessment of the defect tolerance of structures (R6) is described. One of the key elements of the revised version is the recommendation that the failure assessment line should be derived from the actual tensile stress/strain properties of the material. The second part of the Report addresses the validation of the method, which is a crucial step on the way to obtaining acceptance of R6 by, in particular, the regulatory bodies. The range of structures used to validate the procedure is illustrated by two examples. The use of conservative data and assumptions is fundamental to the R6 philosophy, which means that the procedure should not be used as a predictive tool. In the second example the importance of making these conservative assumptions is clearly illustrated. (author)

  19. Residues from waste incineration. Final report. Rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Astrup, T.; Juul Pedersen, A.; Hyks, J.; Frandsen, F.J.

    2010-04-15

    The overall objective of the project was to improve the understanding of the formation and characteristics of residues from waste incineration. This was done focusing on the importance of the waste input and the operational conditions of the furnace. Data and results obtained from the project have been discussed in this report according to the following three overall parts: i) mass flows and element distribution, ii) flue gas/particle partitioning and corrosion/deposition aspects, and iii) residue leaching. This has been done with the intent of structuring the discussion while tacitly acknowledging that these aspects are interrelated and cannot be separated. Overall, it was found that the waste input composition had significant impact of the characteristics of the generated residues. A similar correlation between operational conditions and residue characteristics could not be observed. Consequently, the project recommend that optimization of residue quality should focus on controlling the waste input composition. The project results showed that including specific waste materials (and thereby also excluding the same materials) may have significant effects on the residue composition, residue leaching, aerosol and deposit formation.It is specifically recommended to minimize Cl in the input waste. Based on the project results, it was found that a significant potential for optimization of waste incineration exist. (Author)

  20. Paediatric radiology. 2. enl. and tot. rev. ed.

    International Nuclear Information System (INIS)

    Benz-Bohm, G.

    2005-01-01

    This book presents a current, comprehensive and clearly written introduction to the often-neglected field of paediatric radiology, from important aspects of radiation protection to the specific anatomic features of the growing skeleton and the special anatomy of the thorax and abdomen of newborns and infants. Special knowledge is imparted on the radiology of trauma effects in infant age and the 'battered child syndrome'. The diseases and findings are presented in an organ-specific and topographic manner. There are special chapters on sonography, CT and MRT in infants. The structure of the book serves two purposes. First, the reader can obtain information on specific diseases; secondly, the particular features of examination techniques and the specifics of paediatric radiology are presented. (orig.) [de

  1. Radiological imaging of the neonatal chest. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Donoghue, Veronica (ed.) [Children' s University Hospital, Dublin (Ireland). Dept. of Radiology; National Maternity Hospital, Dublin (Ireland)

    2008-07-01

    This second, revised edition of Radiological Imaging of the Neonatal Chest provides a comprehensive and up-to-date discussion of the subject. It is written primarily from the point of view of the paediatric radiologist but will be of particular interest to all antenatal ultrasonographers, neonatologists, paediatric cardiologists, paediatricians and paediatric surgeons. It includes an update on clinical management and appraises the advantages of the various techniques available to image the newborn chest. There is particular emphasis on the impact of recent therapeutic advances on imaging findings. Extensive consideration is given to both antenatal and postnatal imaging of congenital chest malformations, as well as to controversies regarding the postnatal management of asymptomatic infants with these anomalies. There are dedicated chapters on upper airway problems, infection and congenital heart disease, with special emphasis on the current role of magnetic resonance imaging, computed tomography and interventional therapy. There is also a chapter devoted to computed radiography and digital radiography. This book contains important information for all those involved in caring for the neonate. (orig.)

  2. Columbus' navn hang ved, da Colombia rev sig fri

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2016-01-01

    I 52 år har Colombia været skueplads for en særdeles blodig guerillakrig, som har kostet flere end 220.000 mennesker livet. Når den colombianske præsident, Juan Manuel Santos, i morgen på Oslos rådhus modtager Nobels fredspris, er det ikke bare, fordi Nobelkomitéen håber, at den vil give ham styrke...

  3. Advanced wood burning furnaces. 2. rev. ed.; Moderne Holzfeuerungsanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, W. (comp.)

    2001-07-01

    New and environment-friendly technologies meet high requirements in terms of emission reduction and comfort of operation. In the field of wood burning furnaces, there is still a lack of knowledge which results in excessive cost, environmental pollution and loss of image. This brochure shows how wood furnaces should be operated correctly and also reviews the state of the art. [German] Durch die technische Entwicklung neuer, wirkungsvoller und vor allem umweltfreundlicher Heiztechniken wird zudem den in den letzten Jahren gestiegenen Anforderungen an den Emissionsschutz und den Bedienungskomfort Rechnung getragen. Mit Holz wird jedoch z. T. nicht immer richtig geheizt. Das kostet Geld und fuehrt zu vermeidbaren Umweltbelastungen und Imageschaeden. Ziel dieser Broschuere ist es daher, mit den Techniken des Heizens mit Holz vertraut zu machen und einen Ueberblick ueber den heutigen Stand zu geben. (orig.)

  4. Development of CATHENA Plant Model for Wolsong 1 (Rev.0)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y.H.; Lee, K.H.; Choi, H. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This document includes CATHENA model development of plant controls, steam generator, feedwater and steam piping for wolsong 1 trip coverage analysis in the project of ''Development of Assessment Technologies for CANDU Reactor Power and Trip Effectiveness''. (author). 11 refs., 2 figs., 3 tabs.

  5. Explosive (chemical) substances. 6. rev. and enlarged ed. Explosivstoffe

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, R

    1985-01-01

    The sixth edition of this review manual again has been enlarged and actualized, the proved concept has been maintained. The text describes in large more than 550 items alphabetically, among them about 120 chemical compounds attributed with structure formulas and data. The properties, preparation procedures, and application possibilities of these substances and of about 70 additives, fuels and oxidants are presented for the reader. By nearly 1500 keywords in the index, English and French translations, and explanations of abbreviations, this book becomes a comprehensive and actual dictionary, not only for the specialist, but also for translators, interpreters, newspaper editors, and patent lawyers. (orig./HK).

  6. Dictionary of plastics. 7. rev. ed. Kunststoff-Lexikon

    Energy Technology Data Exchange (ETDEWEB)

    Stoeckhert, K [ed.

    1981-01-01

    The book starts with a list of about 400 acronyms for plastic materials and additives, caoutchouc types, and synthetic fibers. This is followed by a 500-page glossary of plastics and a 200-page appendix listing producers of plastic feedstocks, chemical substances and additives, recoverable materials, processing systems, semi-finished plastic products and end products, machinery, tools and further aids for plastics processing. (HK).

  7. Dictionary of agriculture. 5. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Haensch, G.; Haberkamp de Anton, G.

    1987-01-01

    The fifth edition of the 'Dictionary of Agriculture' has, like its predecessors, been set out in the proven and systematic way, namely according to linguistic subject matter. An alphabetical index in six languages and an additional index of Latin names and terms in current use means that the dictionary can be used as a technical dictionary as well as a systematic guide to terminology. Each term has been consecutively numbered throughout the systematic part of the dictionary. Since these numbers recur in every index, entries are both easy to find and easy to read. A natural selection had constantly to be made from the wealth of possible terms. Wherever possible, however, terms that are characteristic of a particular region have also been taken into account. The same is true of linguistic differences, e.g. between American and British English and between European and American Spanish as well as of regional peculiarities in language use in Germany, Austria, Switzerland, France and Belgium. Where popular plant names in addition to the scientific ones could not be ascertained - as was the case for Spanish, in particular - only the Latin names are listed, in accordance with general practice in Spanish specialist literature. (orig.) [de

  8. Dictionary of centrifugal pumps. 3. rev. ed. Kreiselpumpen Lexikon

    Energy Technology Data Exchange (ETDEWEB)

    Holzenberger, K; Jung, K [comps.

    1989-01-01

    This technical dictionary was brought up to date of the state of the art. The terminology was supplemented with terms referring to centrifugal pumps. There are now almost 700 terms, with their English and French translations. To facilitate usage all the terms of books are listed in alphabetical order at the end of the book. (RHM).

  9. Principles of veterinary radiography. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Douglas, S.W.; Herrtage, M.E.; Williamson, H.D.

    1991-01-01

    This book by Douglas and Williamson about the physical-technical fundamentals of radiology in veterinary medicine was first published in 1977 and the second edition now available has been revised and enlarged. Part 1 gives coverage of the basic physical and technical requirements of the necessary equipment and installations as well as the laws governing radiation protection. In Part 2, exposure techniques and special examinations procedures are described in detail. Contrast-enhanced examinations are dealt with exhaustively. (orig./MG) With 166 figs., 10 tabs [de

  10. Ecology - environmental protection - survival grisis. 3. rev. ed.

    International Nuclear Information System (INIS)

    Schwitte, J.

    1983-01-01

    The concept developed aims to contribute towards the solution of the crisis of human survival by promoting - ecologic knowledge - environmental awareness - environment-protecting behaviour. In substance it comprises five points of emphasis: 1. long-term aspects of the environmental crisis - an introduction into the ecology of civilization, 2. 'Space-ship earth' - terrestrial atmosphere - air pollution, 3. Water - waste water - hydrobiology, 4. Sewage treatment plants - waste water treatment technology, 5. Nuclear power and nuclear fuel cycle - the Harrisburg accident, USA, March 28, 1979 -. A comprehensive bibliography is appended. (orig./HSCH) [de

  11. Longevity of Emplacement Drift Ground Support Materials, Rev. 01

    International Nuclear Information System (INIS)

    David H. Tang

    2000-01-01

    The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for the selection of materials for ground support that will function throughout the preclosure period of a potential repository at Yucca Mountain. The Development Plan (DP) for this analysis is given in Longevity of Emplacement Drift Ground Support Materials (CRWMS M and O 1999a). The objective of this analysis is to update the previous analysis (CRWMS M and O 2000a) to account for related changes in the Ground Control System Description Document (CRWMS M and O 2000b), the Monitored Geologic Repository Project Description Document (CRWMS M and O 1999b), and in environmental conditions, and to provide updated information on candidate ground support materials. Candidate materials for ground support are carbon steel and cement grout. Steel is mainly used for steel sets, lagging, channel, rock bolts, and wire mesh. Cement grout is only considered in the case of grouted rock bolts. Candidate materials for the emplacement drift invert are carbon steel and crushed rock ballast. Materials are evaluated for the repository emplacement drift environment based on the updated thermal loading condition and waste package design. The analysis consists of the following tasks: (1) Identify factors affecting the longevity of ground support materials for use in emplacement drifts; (2) Review existing documents concerning the behavior of candidate ground support materials during the preclosure period; (3) Evaluate impacts of temperature and radiation effects on mechanical and thermal properties of steel. Assess corrosion potential of steel at emplacement drift environment; (4) Evaluate factors affecting longevity of cement grouts for fully grouted rock bolt system. Provide updated information on cement grout mix design for fully grouted rock bolt system; and (5) Evaluate longevity of materials for the emplacement drift invert

  12. A Guide to the Elements, Rev. Edition (by Albert Stwertka)

    Science.gov (United States)

    Berger, Reviewed By Daniel

    1999-12-01

    This edition is identical in format and content to the 1996 edition, now sold as the "library edition", except that the names and information for elements 104-109 have been updated. My earlier review still applies; a page-by-page comparison found this edition identical to the first except as noted in the previous sentence. The major revision has been in size and price. The 50% price reduction is welcome, but the format was not changed when the size was reduced, and the resulting 9-point font puts readers at risk of eyestrain. I would like to correct one of the criticisms in my earlier review There is excellent discussion of the industrial uses of each element, as well as its most common source minerals. The more economically important elements are given extensive discussions, detailing industrial uses of the element and its compounds. However, biological activity is given spotty coverage. There is no mention - under "iron" or elsewhere - of the central biological role of iron in oxygen transport or of magnesium in photosynthesis. When coverage appears it is not bad: the roles of calcium in vertebrate and invertebrate skeletons, of fluorine in reducing tooth decay by changing hydroxyapatite to fluorapatite, and of cobalt in vitamin B12 are discussed. While information on transuranium elements has been updated, there has been no attempt to correct several minor errors in spelling, placement, or even information. On page 14 the 1s subshell appears as part of the L (n = 2) shell, and upon the electrolysis of molten sodium chloride on page 54, "sodium collects atthe cathode, and chloride [sic] at...the anode." On page 73 the etymology of "potash" is still given as "potassium-rich ash" rather than "ash burned down in pots", though it is obvious that the latter is intended. On page 74, a picture caption claims that black powder ("potassium nitrate, wood charcoal, and sulfur") is used in modern, high-powered rifle cartridges. In spite of the mistakes, which are relatively few, there is much good information in this book. The essential chemical properties of each element are detailed so that periodic trends may be easily seen; important industrial uses are presented in some detail; transuranium elements and radioisotopes are given careful coverage; and biological activity is (occasionally) discussed. The presentation is interesting and eye-catching, designed to hold the interest of a student who knows little about chemistry. And now, the price has been made more reasonable. While the hardcover edition remains $35.00, the paperback edition, at half price, should bring this useful book into wider use.

  13. EEG. Renewables Act. Comment. 4. new rev. and enl. ed.

    International Nuclear Information System (INIS)

    Frenz, Walter; Cosack, Tilman

    2015-01-01

    Unlike any other Act, the Renewable Energy Sources Act (EEG) changes continuously. Recently it has been fundamentally transformed with the amendment 2014. Comprehensive, readable and practice-oriented. The proven Berliner comment EEG is your reliable companion through the new regulatory regime. All provisions of the EEG 2014 thorough and easy to understand commented by experts of the matter. 2. The EEG Amending Act of 29.6.2015 has already been considered. A detailed introduction and contributions to the relevant European law and the antitrust aspects of the renewable energy sources to guarantee you a broad understanding of the rules. Valuable background information you provide, the digressions of the most important renewable energy technologies, will explain the pictures thanks to numerous the scientific and technical foundations. Moreover you the construction law aspects in the construction of photovoltaic and wind turbines are explained clearly. [de

  14. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Thomsen, Henrik S. [Copenhagen University Hospital, Herlev (Denmark). Dept. of Diagnostic Radiology; Copenhagen Univ., Herlev (Denmark). Dept. of Diagnostic Sciences; Webb, Judith A.W. (eds.) [St. Bartholomew' s Hospital London Univ. (United Kingdom). Dept. of Radiology

    2009-07-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  15. Radiological protection. Radioactivity and health. 4. rev. ed.

    International Nuclear Information System (INIS)

    Borsch, P.; Feinendegen, L.; Paschke, M.; Feldmann, A.

    1991-12-01

    The brochure tries to make understandable also for nonprofessionals the conncetion between radioactivity and health. After briefly discussing the foundations of radioactivity, radiation emanating from radioactive materials, and the terms of dose, it deals with natural and man-made exposure of man in the age of industry. Its effects on man are thoroughly considered with regard to possible health injuries and genotype changes. The explanation of radioecological correlations, from radioactive effluents from nuclear installations to the determination of radiation exposure of man, takes into account effluents during normal operation and effluents caused by accidents, giving as an example the Chernobyl reactor accident. It is supplemented by describing the risks involved in the application of ionizing radiation in medicine. Subsequent chapters reflect the results obtained in many years of research into questions of radiation hazards, and they are to contribute to a matter-of-fact information about this important area. A comprehensive bibliography facilitates access to specialized literature. (orig.) [de

  16. Diagnostic imaging of the hand. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Schmitt, R.

    2004-01-01

    The second edition contains the following new features: Focus on cogenital, degenerative, inflammatory, tumourous, neurogenic and vascular diseases of the hands; new images of multiline spiral CT including 2D pictures and 3D reconstructions; new MRT images with examination protocols; synoptic presentation of all diseases according to their pathoanatomy, clinical symptoms, diagnostic imaging, differential diagnosis, therapeutic options; checklists for the doctor's everyday work. (orig.)

  17. Nuclear medicine. 4. new rev. and enl. ed.

    International Nuclear Information System (INIS)

    Kuwert, T.; Gruenwald, F.; Haberkorn, U.; Krause, T.

    2008-01-01

    The book on nuclear medicine is devided in three chapters: fundamentals, diagnostics and therapy. The topics within these chapters are the following: 1) fundamentals: molecular imaging; radiation physics, measuring technology and quality control; dosimetry and radiation effects; radiation protection, radiopharmaceutical chemistry; immonoassays and quality control. 2) diagnostics: endocrine organs; oncology; heart, vascular system and blood vessels; brain, lungs, skelton, kidneys, gastrointestine tract; infections; hematology. 3) radiotherapy; radiosynoviorothese; palliative bone pain therapy; radioimmunotherapy; 1 31I-MIBG therapy; therapy with receptor affine peptides; specific nuclear medical therapies

  18. A new approach to physics. Vol. 1. rev. ed.

    International Nuclear Information System (INIS)

    Luescher, E.; Jodl, H.

    1976-01-01

    Using a novel didactic principle, this book intends to give a general survey and to offer approaches of varying degrees of difficulty to all fields of physics. Graphs serve to present physics in general and all its partial aspects in a logical order which is in accordance with the latest state of knowledge. This frame is filled out by the chapters which present their subjects without undue mathematization, supplemented and livened up by practical examples. This first volume contains the chapters on the methods of scientific thinking, matter and energy, the genealogical tree of physics, mechanics, electrodynamics, solid state physics. (GSC) [de

  19. Environmental protection directory. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Schumacher, H.G.

    1993-01-01

    For the first time in this form in Germany, this handbook provides a comprehensive collection of mainly non-commercial environmental protection addresses. It covers the federal, community, scientific and jounalistic areas as well as business and society associations and groups, educational and advisory services and institutions. The addressbook contains the addresses and telephone numbers of the seperate institutions, as well as the names and extension numbers of public officials, representatives and media relations personned of the associations, the party environmental spokesperson and assigned people from the churches, and the ecology editors in media, radio and television. (orig.) [de

  20. Climate change and the Lower Fraser Valley. rev. ed.

    International Nuclear Information System (INIS)

    Taylor, E.; Langlois, D.

    2000-01-01

    The climatic changes that are expected to occur in British Columbia's Lower Fraser Valley over the next century were described in this report which included information about the science of climate change and the development of global climate models that provide estimates of global climate for the coming century. The confidence that scientists have in these models was reflected in the fact that most can simulate the important seasonal and geographical large scale features of the global climate, and that many of the large scale changes that are effected by greenhouse gas concentrations can be explained in terms of physical processes which operate around the world. The models also reproduce with reasonable accuracy the variations of climate such as the El Nino phenomena., the cooling due to the Mount Pinatubo eruption in 1991 and the global warming that occurred over the past 100 years. Three climate stations were analyzed in this study to assess the climate change of the Valley. Climatic change is influenced by increased concentrations of greenhouse gases in the atmosphere which in turn cause accelerated global warming. Scientists generally believe that the combustion of fossil fuels and other human activities are a major reason for the increased concentration of carbon dioxide. Plant respiration and the decomposition of organic matter releases 10 times more CO 2 than that released anthropogenically, but these releases are in balance with plant photosynthesis. The rate of warming in the Lower Fraser Valley is uncertain, but climate models suggest it could be about 3 to 4 degrees warming with wetter winters and drier summers by the end of the century. The Valley currently has mild temperatures and high precipitation because of its proximity to the Pacific Oceans and the surrounding mountains. Global warming can have an impact on sea levels along the coast, spring flooding, summer drought, coastal ecosystems, air quality, occurrences of forest fires, and recreation. The projections stated in this report come from two state of the art global climate models. refs., tabs., figs

  1. Radiation protection course for physicians. 3. rev. ed.

    International Nuclear Information System (INIS)

    Stieve, F.E.

    1979-01-01

    The regulations of the Radiation Protection Ordinance and the X-ray Ordinance concerning the expert training of radiological safety officers and health physicists working in hospitals and general practice require expert knowledge in radiation protection of these persons. Expert knowledge includes knowledge of radiation protection itself but also experience in the medical application of ionizing radiation and radioactive materials and experience required for judging the state of health of persons occupationally exposed to radiation. The discussions between lectures and participants of the radiation protection courses made it necessary to update the textbooks with regard to the latest state of knowledge in radiobiology, radiation hygiene, radiation protection, and legislation. (orig./HP) [de

  2. Wind Farm Wake: The 2016 Horns Rev Photo Case

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Nygaard, Nicolai Gayle; Volker, Patrick

    2017-01-01

    are that a humid and warm air mass was advected from the southwest over cold sea and the dew-point temperature was such that cold-water advection fog formed in a shallow layer. The flow was stably stratified and the freestream wind speed was 13 m/s at hub height, which means that most turbines produced at or near...

  3. An introduction to radioimmunoassay and related techniques. 3. rev. ed.

    International Nuclear Information System (INIS)

    Chard, T.

    1987-01-01

    This book is designed as an introductory text for the staff of clinical or research laboratories who conduct or intend to conduct radioimmunoassay and related immunoassay techniques, and will also be of great value to the clinicians who make use of such services. The emphasis is on general principles with practical illustrations rather than a detailed and encyclopaedic review of the literature. This 3rd revised edition places more emphasis on alternative labels (non-isotopic immunoassays), the use of labelled antibodies (immunometric assays), and the use of monoclonal antibodies. Both principles and practice are illustrated by diagrams and illustrations. (Auth.)

  4. Quantum physics. 9. tot. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Gasiorowicz, S.

    2005-01-01

    This textbook belongs to the mostly favorite and illustrative introductions to quantum physics. The understandable way of presentation allows the independent access of the physical background of the world of quanta. Starting from the physical phenomena the book mediates the fundamental terms and procedures of quantum mechanics and illustrates them by means of extensive application examples and estimations of orders of magnitude. This proximity tro praxis gives to the book its aliveness. For the better understanding Gasiorowicz includes explaining steps and abandons complicated mathematical derivations. The discussion of the physical connections helps in the illustration of formal calculations. By this the successful transition from a course about modern physics to the purely formal development of quantum mechanics is possible. Numerous exercises are found in the extended part of problems. Furthermore the commented list of literature in the appendix is a valuable orientational aid for the study of quantum physics. The 9th edition was completely surveyed, actualized, and extended

  5. Bones - joints - soft tissues II. 7. rev. ed.

    International Nuclear Information System (INIS)

    Dihlmann, W.; Frommhold, W.

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs [de

  6. Radiology trainer. Surgical ambulance. Revision 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Ackermann, Ole; Barkhausen, Joerg

    2013-01-01

    The radiology trainer for surgical ambulance includes informative X-ray imaging examples for the following issues: zygoma, nasal bone, spinal cord, clavicle, shoulder, upper arms, elbow, forearms, wrist, hand, phalanx, thorax, sternum, pelvis, abdomen, hips, femur, knee, lower leg, ankle, feet.

  7. The interpretation of quantum theory. 2. rev. ed.

    International Nuclear Information System (INIS)

    Baumann, K.; Sexl, R.U.

    1986-01-01

    In this volume of the series 'facets of physics' the authors give a survey about the different approaches which were made for the interpretation of quantum mechanics in the last fifty years. The main part of this book is formed by twelve original articles of Born, Heisenberg, Schroedinger, Bohm, Bell et al., which are here partly presented for the first time in German language. (orig./HSI) [de

  8. S-11 and S-20 photocathode research activity. Rev. 1

    International Nuclear Information System (INIS)

    Gex, F.; Huen, T.; Kalibjian, R.

    1984-01-01

    The S-1 semi-transparent photocathode is the only one that can be used to study the 1.06 μm neodynium laser pulses of less than 10 ps duration. We first reviewed the recent results obtained at the Paris Observatory (research sponsored by the CEA), and then we tried to determine the role of the main constituents and their contributions in photoemission

  9. Gas Test Loop Facilities Alternatives Assessment Report Rev 1

    International Nuclear Information System (INIS)

    William J. Skerjanc; William F. Skerjanc

    2005-01-01

    An important task in the Gas Test Loop (GTL) conceptual design was to determine the best facility to serve as host for this apparatus, which will allow fast-flux neutron testing in an existing nuclear facility. A survey was undertaken of domestic and foreign nuclear reactors and accelerator facilities to arrive at that determination. Two major research reactors in the U.S. were considered in detail, the Advanced Test Reactor (ATR) and the High Flux Isotope Reactor (HFIR), each with sufficient power to attain the required neutron fluxes. HFIR routinely operates near its design power limit of 100 MW. ATR has traditionally operated at less than half its design power limit of 250 MW. Both of these reactors should be available for at least the next 30 years. The other major U.S. research reactor, the Missouri University Research Reactor, does not have sufficient power to reach the required neutron flux nor do the smaller research reactors. Of the foreign reactors investigated, BOR-60 is perhaps the most attractive. Monju and BN 600 are power reactors for their respective electrical grids. Although the Joyo reactor is vigorously campaigning for customers, local laws regarding transport of radioactive material mean it would be very difficult to retrieve test articles from either Japanese reactor for post irradiation examination. PHENIX is scheduled to close in 2008 and is fully booked until then. FBTR is limited to domestic (Indian) users only. Data quality is often suspect in Russia. The only accelerator seriously considered was the Fuel and Material Test Station (FMTS) currently proposed for operation at Los Alamos National Laboratory. The neutron spectrum in FMTS is similar to that found in a fast reactor, but it has a pronounced high-energy tail that is atypical of fast fission reactor spectra. First irradiation in the FMTS is being contemplated for 2008. Detailed review of these facilities resulted in the recommendation that the ATR would be the best host for the GTL

  10. Environmental law. 2. rev. and enl. ed.; Umweltrecht

    Energy Technology Data Exchange (ETDEWEB)

    Koch, H.J. (ed.) [Hamburg Univ. (Germany). Forschungsstelle Umweltrecht

    2007-07-01

    The text book under consideration already is addressed to lawyers and students of jurisprudence. It enables an introduction into the general environmental law and consists of sixteen autonomous chapters: (a) International law in the field of ecology (Matthias Buck, Roda Verheyen); (b) European and national environmental constitutional law (Johannes Caspar); (c) General environmental administrative law (Ulrich Ramsauer); (d) Pollution abatement law (Hans-Joachim Koch); (e) Water protection law (Silke Laskowski, Cornelia Ziehm); (f) Recycling economy law and waste management law (Martin Dieckmann, Moritz Reese); (g) Nature conservation law (Christian Maass, Peter Schuette); (h) Soil conservation law and contaminated sites law (Nikolaus Herrmann); (i) Energy legal regulations as an instrument of environmental protection (Wolfgang Ewer); (j) Atomic energy law (Klaus Jankowski); (k) Genetic engineering law (Ursula Prall); (l) Law of hazardous materials (Eckhard Pache); (m) Environmental law in planning law (Nikolaus Hermann); (n) Environment and traffic (Philipp Hermann, Ekkehard Hofmann); (o) Agriculture and ecology (Ulf-Henning Moeker); (p) Liberal trade and environmental protection (Matthias Buck).

  11. Environmental law. 2. rev. and enl. ed.; Umweltrecht

    Energy Technology Data Exchange (ETDEWEB)

    Erbguth, W. [Rostock Univ. (Germany); Schlacke, S. [Bremen Univ. (Germany)

    2008-07-01

    The text book under consideration is addressed to students of jurisprudence. It enables an entrance into the general environment law and into selected areas of the special environment law in a clear and systematic form. After an introduction of fundamental principles of the environment law, the book consists of the following topics: Basic principles of the environment law; environmental constitutional law; instruments of the environment law; legal protection in the environment law; environmental European right; environmental international law; pollution protection law; wilderness protection act and landscape conservation act, water protection right, act on recycling and waste management, soil conservation law and contaminated site law, genetic engineering law, sea environment law for the protection of the North Sea and Baltic Sea, energy right.

  12. The care of radiation casualities. 6. rev. ed.

    International Nuclear Information System (INIS)

    Carpaij, W.J.M.; Keverling Buisman, A.S.

    1981-01-01

    This manual describes in detail all routine procedures taken by the Occupational Health Service of the Health Protection Department of ECN in case of a personal contamination with radioactive materials and/or overexposure with ionising radiation. The appendices contain information concerning limits of intake and all forms and registration-charts used in these procedures. (orig.)

  13. Quantum invariants of knots and 3-manifolds. 2. rev. ed.

    International Nuclear Information System (INIS)

    Turaev, Vladimir G.

    2010-01-01

    Due to the strong appeal and wide use of this monograph, it is now available in its second revised edition. The monograph gives a systematic treatment of 3-dimensional topological quantum field theories (TQFTs) based on the work of the author with N. Reshetikhin and O. Viro. This subject was inspired by the discovery of the Jones polynomial of knots and the Witten-Chern-Simons field theory. On the algebraic side, the study of 3-dimensional TQFTs has been influenced by the theory of braided categories and the theory of quantum groups. The book is divided into three parts. Part I presents a construction of 3-dimensional TQFTs and 2-dimensional modular functors from so-called modular categories. This gives a vast class of knot invariants and 3-manifold invariants as well as a class of linear representations of the mapping class groups of surfaces. In Part II the technique of 6j-symbols is used to define state sum invariants of 3-manifolds. Their relation to the TQFTs constructed in Part I is established via the theory of shadows. Part III provides constructions of modular categories, based on quantum groups and skein modules of tangles in the 3-space. This fundamental contribution to topological quantum field theory is accessible to graduate students in mathematics and physics with knowledge of basic algebra and topology. It is an indispensable source for everyone who wishes to enter the forefront of this fascinating area at the borderline of mathematics and physics. From the contents: - Invariants of graphs in Euclidean 3-space and of closed 3-manifolds - Foundations of topological quantum field theory - Three-dimensional topological quantum field theory - Two-dimensional modular functors - 6j-symbols - Simplicial state sums on 3-manifolds - Shadows of manifolds and state sums on shadows - Constructions of modular categories. (orig.)

  14. The Chernobyl reactor accident and its consequences. 3. rev. ed.

    International Nuclear Information System (INIS)

    1987-01-01

    The report presents a comprehensive survey of measured data explaining the radiation exposure in the Land Hessen, and a chronological survey of the decisions and measures taken by the Hessian regional government in response to the Chernobyl reactor accident. The measures for instance included selection of appropriate measuring methods and sites, checking of various environmental material, waste disposal surveillance, and dose assessments, and a range of monitoring programmes. (PW) [de

  15. Horns Rev II, 2D-Model Tests

    DEFF Research Database (Denmark)

    Andersen, Thomas Lykke; Brorsen, Michael

    This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), Denmark. The starting point for the present report is the previously carried out run-up tests described in Lykke Andersen & Frigaard, 2006. The......-shaped access platforms on piles. The Model tests include mainly regular waves and a few irregular wave tests. These tests have been conducted at Aalborg University from 9. November, 2006 to 17. November, 2006.......This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU), Denmark. The starting point for the present report is the previously carried out run-up tests described in Lykke Andersen & Frigaard, 2006....... The objective of the tests was to investigate the impact pressures generated on a horizontal platform and a cone platform for selected sea states calibrated by Lykke Andersen & Frigaard, 2006. The measurements should be used for assessment of slamming coefficients for the design of horizontal and cone...

  16. Horns Rev II, 2D-Model Tests

    DEFF Research Database (Denmark)

    Andersen, Thomas Lykke; Frigaard, Peter

    This report present the results of 2D physical model tests carried out in the shallow wave flume at Dept. of Civil Engineering, Aalborg University (AAU). The objective of the tests was: To investigate the combined influence of the pile diameter to water depth ratio and the wave height to water...... depth ratio on wave run-up of piles. The measurements should be used to design access platforms on piles. The Model tests include: Calibration of regular and irregular sea states at the location of the pile (without structure in place). Measurement of wave run-up for the calibrated sea states...... on the front side of the pile (0 to 90 degrees). These tests have been conducted at Aalborg University from 9. October, 2006 to 8. November, 2006. Unless otherwise mentioned, all values given in this report are in model scale....

  17. Contrast media in diagnostic radiology. 3. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Elke, M.; Gueckel, C.; Schmitt, H.E.; Felder, E.; Froehlich, J.M.; Radue, E.W.; Scheidegger, D.; Speck, U.

    1992-01-01

    With the 3rd edition of this book a comprehensive description is provided of all the properties and side-effects of contrast media as well as of the available remedies in mishaps caused by these agents. The individual chapters are headed as follows: (s. table of contents). 1. Introduction. 2. Contrast media for X-ray radiography, MRT, and ultrasonic scanning. 3. Kinetics of X-ray contrast media. 4. Pharamcodynamics of X-ray contrast media. 5. Side-effects of X-ray contrast media and complications encountered in practical radiology. 6. The mobile reanimation unit and the emergency kit. 7. Treatment of reactions to contrast media. 8. Appendix. 9. Bibliography, subject index. (orig./MG) With 25 figs., 5 text tabs., 39 tabs [de

  18. An introduction to heat transfer. 2. rev. ed.

    International Nuclear Information System (INIS)

    Hell, F.

    1979-01-01

    This book represents a fundamental introduction to heat transfer. Practical problems and tables make the book useful for engeneers and students. The chapters include detailed informations together with exercises of convection, radiat heat transfer, thermal conduction and condensation. (CDS)

  19. Secure Autonomous Automated Scheduling (SAAS). Rev. 1.1

    Science.gov (United States)

    Walke, Jon G.; Dikeman, Larry; Sage, Stephen P.; Miller, Eric M.

    2010-01-01

    This report describes network-centric operations, where a virtual mission operations center autonomously receives sensor triggers, and schedules space and ground assets using Internet-based technologies and service-oriented architectures. For proof-of-concept purposes, sensor triggers are received from the United States Geological Survey (USGS) to determine targets for space-based sensors. The Surrey Satellite Technology Limited (SSTL) Disaster Monitoring Constellation satellite, the UK-DMC, is used as the space-based sensor. The UK-DMC's availability is determined via machine-to-machine communications using SSTL's mission planning system. Access to/from the UK-DMC for tasking and sensor data is via SSTL's and Universal Space Network's (USN) ground assets. The availability and scheduling of USN's assets can also be performed autonomously via machine-to-machine communications. All communication, both on the ground and between ground and space, uses open Internet standards

  20. Hydrogen as an energy carrier. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Winter, C.J.; Nitsch, J.

    1991-01-01

    This book deals with the possibilities of an energetic utilisation of hydrogen. This energy carrier can be produced from the unlimited energy sources - solar energy, wind energy and hydropower - and from nuclear energy. It is also capable of one day supplementing or superseding the fossil energy carriers oil, coal and gas. What is special about the book is that it goes beyond a mere physical/technical description to discuss the economic and political aspects and ecological effects and requirements that are an essential part of sound energy planning today. Thus, the authors and editors outline the step-by-step development of a hydrogen economy, mainly based on solar energy, providing a solution to both the pollution problems caused by the use of fossil energy carriers and the energy requirements of the third world. (orig.) With 197 figs., 71 tabs

  1. Data relating to the environment 1984. 2. rev. ed.

    International Nuclear Information System (INIS)

    Augustin, K.; Fischer, D.; Holz, A.; Kumm, A.; Langer, H.

    1984-01-01

    'Data relating to the environment' is a work of reference containing in concentrated form a large number of so far individually published data presented as sets of information and mostly arranged in graphic form. This facilitates also the interlinking of data from different fields. The data are divided according to ten subject categories: 1) data on energy and national economy; 2) nature and landscape; 3) soil; 4) forest; 5) air; 6) water; 7) refuse; 8) noise; 9) radioactivity; 10) food. They do not constitute an environmental quality report. For the sector radioactivity not only emission and immission data were compiled but also the measuring networks for monitoring natural radiation exposure and many measuring values from air, soil and waters for the year 1980 respectively for the period from 1960 to 1980 are indicated. (HP) [de

  2. Sandia National Laboratories Internal Dosimetry Technical Basis Manual (Rev 4)

    Energy Technology Data Exchange (ETDEWEB)

    Goke, Sarah Hayes [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Elliott, Nathan Ryan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    The Sandia National Laboratories’ Internal Dosimetry Technical Basis Manual is intended to provide extended technical discussion and justification of the internal dosimetry program at SNL. It serves to record the approach to evaluating internal doses from radiobioassay data, and where appropriate, from workplace monitoring data per the Department of Energy Internal Dosimetry Program Guide DOE G 441.1C. The discussion contained herein is directed primarily to current and future SNL internal dosimetrists. In an effort to conserve space in the TBM and avoid duplication, it contains numerous references providing an entry point into the internal dosimetry literature relevant to this program. The TBM is not intended to act as a policy or procedure statement, but will supplement the information normally found in procedures or policy documents. The internal dosimetry program outlined in this manual is intended to meet the requirements of Federal Rule 10CFR835 for monitoring the workplace and for assessing internal radiation doses to workers.

  3. How to find technical information. Vol. 1. 2. rev. ed.

    International Nuclear Information System (INIS)

    Joswig, W.; Heidtmann, F.

    1987-01-01

    This introduction into the technique of finding and procuring special technical literature is addressed to students and post-graduate students engaged in this work. The part on library organization contains a sketch on how to procure information, while the part dealing with bibliographical material lists the most important instruments for the retrieval of special technical information. A library and bibliographical terminology and an index are appended. (DG) [de

  4. Air pollution prevention manual on emission monitoring. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-08-15

    The Manual on Emission Monitoring covers the need for information about the national practice in the field of emission control at plants, requiring official approval. The legal bases for discontinuous and continuous measurements for emission control at plants, requiring official approval, are treated. Thereby also the European environmental legislation is considered. The publication procedure for testing institutes, which execute such measurements, is described. The execution of discontinuous emission measurements (course of the measurement and measurement requests) and for continuous emission measurement (suitability test, installation, maintenance, functional test and calibration of the automated measuring system) including the evaluation and documentation of the measured values is described. The procedure of remote emission monitoring is explained. The most important measuring procedures (continuous and discontinuous) are reported. The guide also includes an up-to-date list of tested and appropriate measurement devices. Such tested measuring devices are described by their manufacturers. Indications are given as to how the devices function together with their technical data (e. g. parameters from the suitability test). (orig.)

  5. A doxology to Christ (Rev. 1:5e-6

    Directory of Open Access Journals (Sweden)

    J. C. de Smidt

    2006-07-01

    Full Text Available Revelation 1:5e-6 is a doxology, an eulogy on the characteristics (attributes of Christ. Christ’s churches celebrate the enduring love of Christ, who by a once-and-for-all historical act redeemed them from enslavement to sin. Through this redemptive achievement Christ obtained royal and priestly prerogatives for believers in the present. The meaning of this doxology is investigated from a “heilgeschichtlich” and covenantal context. The acts of Christ are framed by the acts of God; God thus is the “Principium Essendi”. The point of departure in this article is that an ontological relationship exists between the theologia naturalis and the theologia supra- naturalis in the final phase of God’s kingdom.

  6. The care of radiation casualties. 6. rev. ed.

    International Nuclear Information System (INIS)

    Carpaij, W.J.M.; Keverling Buisman, A.S.

    1981-01-01

    All routine procedures taken by the Occupational Health Service of the Health Protection Department of ECN in case of a personal contamination with radioactive materials and/or overexposure with ionising radiation are described in detail. The appendices contain information concerning limits of intake and all forms and registration-charts used in these procedures

  7. 110 A CRITICAL DISCOURSE ANALYSIS OF REV. FR. PROF. BAC ...

    African Journals Online (AJOL)

    seeing the text as the product of a process of production, and as a resource in the ... Mind control is, therefore, a function of texts and talks, and does not always mean ... does not mean critique in the negative sense of it, but fostering in-depth ... refers to the social factors that lead to the production of a text and the effect of ...

  8. Electric power distribution. 5th Rev. Ed. Elektrische Energieverteilung

    Energy Technology Data Exchange (ETDEWEB)

    Flosdorff, R; Hilgarth, G

    1986-01-01

    The first chapter on electric power supply networks discusses transmitting media, their characteristic values, and the dimensioning of electric lines and networks; cables are given particular attention. High-voltage d.c. transmission and reactive power compensation are discussed. The next chapter describes the calculation of short-circuits and earth leakages for various neutral circuits on the basis of symmetric components. The newly introduced mesh current method for complex calculation of electric networks makes use of the potential of pocket computers. Chapter 3 discusses protective devices, i.e. earth systems and electronic protection. The next two chapters describe switch gear and power plants, including recent technical changes. The final chapter, which discusses the electric power industry, has been rewritten and extended. Methods of calculation, e.g. annual cost and cash value, are applied to transmitting media and plants. There is an extensive appendix with characteristic values of cables and overhead lines, graphical symbols, distinguishing signs of wiring diagrams, a bibliography of books, DIN standards, VDE specifications, and formulas.

  9. Circuit drawings in electrical energy technology. 6. rev. ed.

    International Nuclear Information System (INIS)

    Weinert, J.

    1991-01-01

    This book contains a survey of the most important standards for graphical symbols and circuit documents for the area of electrical energy technology; it explains the circuit symbols in their construction and in their material and mental contents of terms; it contains a comparison of the circuit symbols from the DIN standards and the new DINTEC symbols taken from harmonisation, produced by arrangement in the picture column with the addition of the letters IEC; it contains a selection of circuit symbols of the IEC, USA, Canada and Great Britain; it supplements the necessary standards for producing circuit documents by extracts and references; it shows examples for the symbols of electrical equipment by using circuit symbols; it develops and explains the various kinds of representation of electrical circuits by circuit diagrams; it leads to reading and understanding the functioning of circuits by descriptions of functions; it gives examples of applications for designing and producing circuit documents, as used in practice; it contributes to arranging electrical plant according to the 'recognised rules of electrical engineering' and increasing safety by reference to the DIN-VDE regulations connected with representation, and it is a great help in designing electrical energy plant by its technical and electrical data. (orig.) [de

  10. An introduction to magnetic resonance in medicine. 2. rev. ed.

    International Nuclear Information System (INIS)

    Rinck, P.A.; Muller, R.N.; Petersen, S.B.

    1990-01-01

    The second edition of this introduction to magnetic resonance in medicine is published five years after the first. During these years, magnetic resonance has established itself as a leading diagnostic modality in medicine. With the introduction of fast imaging methods and contrast agents, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have become even more complicated and complex than before. The purpose of this introduction to biomedical MRI and MRS is to give the readers a basic knowledge that will make it possible for them to pursue studies of their own and to cope with some of the most common problems such as image artifacts or patient questions concerning possible hazards of magnetic resonance. (orig./MG) With 99 figs., 11 tabs

  11. Radiation protection training courses for physicians. 5. rev. ed.

    International Nuclear Information System (INIS)

    Stieve, F.E.

    1994-01-01

    The material for the basic course has been reviewed and updated in response to the 1987 amendment of the X-ray Ordinance and the 1989 amendment of the Radiation Protection Ordinance, and also takes into account the related directives and recommendations, including the ICRP recommendations published in 1990. The main subjects covered by the basic course are: (1) Fundamentals of radiation physics. (2) Fundamentals of radiobiology, genetic effects. (3) Basic principles of radiation protection. (4) Principles and concepts of dosimetry. (5) Natural and man-made radiation exposure. (6) Radiation accident management. (7) International and national legislation and sub-ordinate legislation. (8) Quality assurance and quality testing. (9) Tasks of the radiological safety officer. (10) Exercises and new units and quantities. (HP) [de

  12. ADVANTG An Automated Variance Reduction Parameter Generator, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Mosher, Scott W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Seth R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevill, Aaron M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ibrahim, Ahmad M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Daily, Charles R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Evans, Thomas M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wagner, John C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Jeffrey O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Grove, Robert E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-08-01

    The primary objective of ADVANTG is to reduce both the user effort and the computational time required to obtain accurate and precise tally estimates across a broad range of challenging transport applications. ADVANTG has been applied to simulations of real-world radiation shielding, detection, and neutron activation problems. Examples of shielding applications include material damage and dose rate analyses of the Oak Ridge National Laboratory (ORNL) Spallation Neutron Source and High Flux Isotope Reactor (Risner and Blakeman 2013) and the ITER Tokamak (Ibrahim et al. 2011). ADVANTG has been applied to a suite of radiation detection, safeguards, and special nuclear material movement detection test problems (Shaver et al. 2011). ADVANTG has also been used in the prediction of activation rates within light water reactor facilities (Pantelias and Mosher 2013). In these projects, ADVANTG was demonstrated to significantly increase the tally figure of merit (FOM) relative to an analog MCNP simulation. The ADVANTG-generated parameters were also shown to be more effective than manually generated geometry splitting parameters.

  13. Geology plus growth equals prosperity. 2. rev. ed.

    International Nuclear Information System (INIS)

    Linke, H.; Spoenemann, G.H.

    1986-01-01

    The book has its origins in a series of seminars held from 1978 to 1985 which proposed to trigger a rational discussion in the public sector. The contributors' central statements and important ideas have been extended and updated. Emphasis is placed in the book on the following: Pollutants and pollution loads; developments in the sector of energy; environmental pollution and economic growth; 'green' policy as an ideology; environmental protection industry. The book arrives at the conclusion that ecology and economic growth do not exclude one another but are, on the contrary, contingent on one another. The key for the enhancement of economic efficiency, notwithstanding increased environmental protection efforts, lies in rationalization or in the use of new technologies. (HSCH) [de

  14. Course on radiology and radiation protection. 3. rev. enl. ed.

    International Nuclear Information System (INIS)

    1981-01-01

    This book shall serve as accompanying study text-book for students of medicine, who are in the clinical semesters in the course on radiology and radiation protection. The book deals in general with the field of radiology, starting from the physical and radiobiological fundamentals, through the large field of X-ray diagnostics and radiotherapy to nuclear medicine, including computerized tomography. Broad space is dedicated to radiation protection. A brief, strongly didactically divided text presents this large scientific field of knowledge in systematic order. It is illustrated by numerous tables and sketches, which shall facilitate understanding in cases of difficult problems. The book is completed by a detailed time table, by references to the essential and most important advancing literature and by a comprehensive subject index. (orig./HP) [de

  15. Expert knowledge in radiation protection. 2. rev. ed.

    International Nuclear Information System (INIS)

    Spang, A.

    1990-01-01

    This revised version of the first edition, which was published in 1983, incorporates the full scale of developments and changes made since then, as e.g.: the new Radiation Protection Ordinance, which introduces the concept and definition of effective dose, ED, and limits the maximum permissible occupational exposure to 400 mSv. Changes have become effective for instance in the transport regulations, in the regulations for radioactive waste delivery and collection, in the field of health physics, and with regard to activities under outside contract; b) the EURATOM basic standards and the new SI units: Becquerel and Sievert have replaced Curie and Rem; c) a number of ICRP recommendations, events and scientific results, which frequently make radiation protection more plausible, or sometimes even necessary; d) the new DIN standards and BMU regulations, which also are a valuable source of reference for the radiation protection officer. (orig./HP) [de

  16. Pellet fired appliances. Market survey. 7. rev. ed.; Pelletheizungen. Marktuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-01-15

    The market survey under consideration reports on pellet central heating systems and pellet fired appliances. The main chapters of this market survey are concerned to: (1) Information on wood pellets and pellet fired appliances; (2) Information about the interpretation of the market survey; (3) Survey of all compared pellet fired appliances with respect to the nominal power; (4) Price lists of pellet fired appliances and pellet central heating systems; (5) Type sheets of the compared pellet fired appliances and pellet central heating systems. Finally, this brochure contains the addresses of the produces and distribution partners of pellet fired appliances and pellet central heating systems.

  17. Russia’s Approach to Cyber Warfare (1Rev)

    Science.gov (United States)

    2017-03-01

    head of the Department of Information Security at Moscow State University .” “’Information Troops’ -- a Russian Cyber Command?” 2011 3rd International... University graduates with computer science backgrounds are difficult to recruit because they tend to have better job options in the private tech sector...Websites Tied to Mob , Russian government,” LA Times, August 13, 2008, http://latimesblogs.latimes.com/technology/2008/08/experts- debate.html, featured in

  18. Paljudele puhkus, noortele ärev aeg / Tõnis Lukas

    Index Scriptorium Estoniae

    Lukas, Tõnis, 1962-

    2002-01-01

    Ilmunud ka: Pärnu Postimees 1. august lk. 10, Lääne-Harju Ekspress 3. august lk. 2, Hiiumaa 1. august lk. 2, Põhjarannik ; Severnoje Poberezhje 1. august lk. 2, Elva Postipoiss 3. august lk. 6, Meie Maa 2. august lk. 2, Hiiu Leht : Käina Kuller 6. august lk. 4, Järva Teataja 6. august lk. 2, Vooremaa 6. august lk. 2, Valgamaalane 6. august lk. 2, Nädaline 8. august lk. 4, Lääne Elu 6. august lk. 4, Tartu : Postimees 9. august lk. 2, Harjumaa 13. august lk. 3, Koit 13. august lk. 6, Harju Uudised 7. august lk. 9. Riigikogu liikme sõnul võivad palgavahed korraliku hariduse ühele osale Eesti elanikest kättesaamatuks teha. Autor: Isamaaliit. Parlamendisaadik

  19. Multi-pack Disposal Concepts for Spent Fuel (Rev. 0)

    Energy Technology Data Exchange (ETDEWEB)

    Hadgu, Teklu [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Matteo, Edward N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    At the initiation of the Used Fuel Disposition (UFD) R&D campaign, international geologic disposal programs and past work in the U.S. were surveyed to identify viable disposal concepts for crystalline, clay/shale, and salt host media (Hardin et al., 2012). Concepts for disposal of commercial spent nuclear fuel (SNF) and high-level waste (HLW) from reprocessing are relatively advanced in countries such as Finland, France, and Sweden. The UFD work quickly showed that these international concepts are all “enclosed,” whereby waste packages are emplaced in direct or close contact with natural or engineered materials . Alternative “open” modes (emplacement tunnels are kept open after emplacement for extended ventilation) have been limited to the Yucca Mountain License Application Design (CRWMS M&O, 1999). Thermal analysis showed that, if “enclosed” concepts are constrained by peak package/buffer temperature, waste package capacity is limited to 4 PWR assemblies (or 9-BWR) in all media except salt. This information motivated separate studies: 1) extend the peak temperature tolerance of backfill materials, which is ongoing; and 2) develop small canisters (up to 4-PWR size) that can be grouped in larger multi-pack units for convenience of storage, transportation, and possibly disposal (should the disposal concept permit larger packages). A recent result from the second line of investigation is the Task Order 18 report: Generic Design for Small Standardized Transportation, Aging and Disposal Canister Systems (EnergySolution, 2015). This report identifies disposal concepts for the small canisters (4-PWR size) drawing heavily on previous work, and for the multi-pack (16-PWR or 36-BWR).

  20. Exercises in diagnostic radiology. Vol. 1. 4. rev. ed.

    International Nuclear Information System (INIS)

    Squire, L.F.; Colaiace, W.M.; Strutynsky, N.

    1983-01-01

    Intention of this book is to impart - by means of numerous exercises to be done - knowledge about radiology. It shall be used around the termination of the study of medicine, more or less in the sense of a self-test and supplement of the previous lectures and previously revised text books. The exercises of this first volume proceed from a certain knowledge about thorax radiology to be present. (orig./MG) [de

  1. License Application Design Selection Report, REV 01. August 1999

    International Nuclear Information System (INIS)

    Hastings, C.R.

    1999-01-01

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value as elements of a repository design. In Phase II, these enhanced design alternatives were refined, screened for accepatable postclosure performance, and evaluated against a set of criteria addressing four broad aspects of the repository: performance demonstrability; flexibility; construction, operations and maintenance; and cost. Based on this evaluation, a conceptual design was recommended to DOE and could be characterized as a low thermal impact design. Included in the report is more in depth information regarding the basis of the recommendation, performance issues, benefits related to reduced uncertainties, construction/operational benefits, technical and programmatic flexibilty and cost impacts

  2. CLINICAL APPLICATION OF TUMOUR MARKERS: A REvIEw

    African Journals Online (AJOL)

    2009-12-02

    Dec 2, 2009 ... antigen (CEA), alphafetoprotein (AFP), prostate specific antigen (PSA), CA-125 and ... for use in treatment monitoring of colorectal, hepatocellular, prostatic, ovarian and .... Other causes of PSA elevation include benign.

  3. Specification of advanced safety modeling requirements (Rev. 0)

    International Nuclear Information System (INIS)

    Fanning, T. H.; Tautges, T. J.

    2008-01-01

    The U.S. Department of Energy's Global Nuclear Energy Partnership has lead to renewed interest in liquid-metal-cooled fast reactors for the purpose of closing the nuclear fuel cycle and making more efficient use of future repository capacity. However, the U.S. has not designed or constructed a fast reactor in nearly 30 years. Accurate, high-fidelity, whole-plant dynamics safety simulations will play a crucial role by providing confidence that component and system designs will satisfy established design limits and safety margins under a wide variety of operational, design basis, and beyond design basis transient conditions. Current modeling capabilities for fast reactor safety analyses have resulted from several hundred person-years of code development effort supported by experimental validation. The broad spectrum of mechanistic and phenomenological models that have been developed represent an enormous amount of institutional knowledge that needs to be maintained. Complicating this, the existing code architectures for safety modeling evolved from programming practices of the 1970s. This has lead to monolithic applications with interdependent data models which require significant knowledge of the complexities of the entire code in order for each component to be maintained. In order to develop an advanced fast reactor safety modeling capability, the limitations of the existing code architecture must be overcome while preserving the capabilities that already exist. To accomplish this, a set of advanced safety modeling requirements is defined, based on modern programming practices, that focuses on modular development within a flexible coupling framework. An approach for integrating the existing capabilities of the SAS4A/SASSYS-1 fast reactor safety analysis code into the SHARP framework is provided in order to preserve existing capabilities while providing a smooth transition to advanced modeling capabilities. In doing this, the advanced fast reactor safety models will target leadership-class computing architectures for massively-parallel high-fidelity computations while providing continued support for rapid prototyping using modest fidelity computations on multiple-core desktop platforms

  4. Active Diagnosis of Navy Machinery Rev 2.0

    Science.gov (United States)

    2016-10-01

    electrical distribution and potable water supply systems. Because of these dependencies, ship auxiliary system failures can cause combat load failure...buildup generally causes a pipe to disconnect from a junction, causing water to leak . This limits the faults that are testable, since many of the faults...pipes, junctions, pumps, flow meters, thermal loads, check valve, and water tank. Each agent is responsible for maintaining its constraints locally

  5. Techniques for nuclear and particle physics experiments. 2. rev. ed.

    International Nuclear Information System (INIS)

    Leo, W.R.

    1992-01-01

    This book is an outgrowth of an advanced laboratory course in experimental nuclear and particle physics the author gave to physics majors at the University of Geneva during the years 1978- 1983. The course was offered to third and fourth year students, the latter of which had, at this point in their studies, chosen to specialize in experimental nuclear or particle physics. This implied that they would go on to do a 'diplome' thesis with one of the high- or intermediate-energy research groups in the physics department. The format of the course was such that the students were required to concentrate on only one experiment during the trimester, rather than perform a series of experiments as is more typical of a traditional course of this type. Their tasks thus included planning the experiment, learning the relevant techniques, setting up and troubleshooting the measuring apparatus, calibration, data-taking and analysis, as well as responsibility for maintaining their equipment, i.e., tasks resembling those in a real experiment. This more intensive involvement provided the students with a better understanding of the experimental problems encountered in a professional experiment and helped instill a certain independence and confidence which would prepare them for entry into a research group in the department. Teaching assistants were presented to help the students during the trimester and a series of weekly lectures was also given on various topics in experimental nuclear and particle physics. This included general information on detectors, nuclear electronics, statistics, the interaction of radiation in matter, etc., and a good deal of practical information for actually doing experiments. (orig.) With 254 figs

  6. Contrast media. Safety issues and ESUR guidelines. 2. rev. ed.

    International Nuclear Information System (INIS)

    Thomsen, Henrik S.; Copenhagen Univ., Herlev; Webb, Judith A.W.

    2009-01-01

    In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned members, reviewed the literature, proposed guidelines and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006. This second edition not only updates the previous edition, but also contains some completely new chapters, for example on gadolinium-based contrast agents, meta-analyses in contrast media research and various regulatory issues. Comprehensive consideration is given to the many different safety issues relating to iodinated, MR, ultrasound and barium contrast media. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All those questions frequently raised in radiological practice are addressed, and the well-known ESUR guidelines on contrast media are included. This book, presented in a handy, easy to use format, provides an invaluable, unique and unparalleled source of information on the safety issues relating to contrast media. (orig.)

  7. Orthopaedic positioning in diagnostic radiology. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Bernau, A.

    1990-01-01

    Effective roentgenology of the skeletal system very much relies on good knowledge of three main factors, namely patient positioning, film cassette positioning, and radiation field. The functional approach developed in orthopaedic diagnostics has been adopted for practical adjustment techniques in all X-ray examinations, so that e.g. examinations of the vertebral column and lower extremities now are carried out in upright position instead of the lying position, which of course corresponds to the real functional demand. In order to guarantee good reproducibility of X-ray images, a high standardization of positioning and adjustment techniques is to be achieved. The aspect of optimum radiological protection is also discussed, referring to shielding of the gonads, foils, measures for reduction of scattered radiation fields, and unambiguous labelling of film material. (orig./GDG) With 490 figs. and 1 separate folded tab [de

  8. Social aspects of the nuclear energy. Public acceptance. Rev. 2

    International Nuclear Information System (INIS)

    1993-03-01

    This report approaches the social aspects of the nuclear energy an public acceptance. It presents the following main topics: the societal participation; information and opinion research surveys; historical of the public opposition to the nuclear energy; emergency planning; legislation related to the popular participation; best strategies to acceptance; insurance of nuclear risks; protection of the population and the environment in the licensing; and organization of the licensing system

  9. 188Re(V) Nitrido Radiopharmaceuticals for Radionuclide Therapy.

    Science.gov (United States)

    Boschi, Alessandra; Martini, Petra; Uccelli, Licia

    2017-01-19

    The favorable nuclear properties of rhenium-188 for therapeutic application are described, together with new methods for the preparation of high yield and stable 188 Re radiopharmaceuticals characterized by the presence of the nitride rhenium core in their final chemical structure. 188 Re is readily available from an 188 W/ 188 Re generator system and a parallelism between the general synthetic procedures applied for the preparation of nitride technetium-99m and rhenium-188 theranostics radiopharmaceuticals is reported. Although some differences between the chemical characteristics of the two metallic nitrido fragments are highlighted, it is apparent that the same general procedures developed for the labelling of biologically active molecules with technetium-99m can be applied to rhenium-188 with minor modification. The availability of these chemical strategies, that allow the obtainment, in very high yield and in physiological condition, of 188 Re radiopharmaceuticals, gives a new attractive prospective to employ this radionuclide for therapeutic applications.

  10. 188Re(V) Nitrido Radiopharmaceuticals for Radionuclide Therapy

    Science.gov (United States)

    Boschi, Alessandra; Martini, Petra; Uccelli, Licia

    2017-01-01

    The favorable nuclear properties of rhenium-188 for therapeutic application are described, together with new methods for the preparation of high yield and stable 188Re radiopharmaceuticals characterized by the presence of the nitride rhenium core in their final chemical structure. 188Re is readily available from an 188W/188Re generator system and a parallelism between the general synthetic procedures applied for the preparation of nitride technetium-99m and rhenium-188 theranostics radiopharmaceuticals is reported. Although some differences between the chemical characteristics of the two metallic nitrido fragments are highlighted, it is apparent that the same general procedures developed for the labelling of biologically active molecules with technetium-99m can be applied to rhenium-188 with minor modification. The availability of these chemical strategies, that allow the obtainment, in very high yield and in physiological condition, of 188Re radiopharmaceuticals, gives a new attractive prospective to employ this radionuclide for therapeutic applications. PMID:28106830

  11. Radiology of haemophilic arthropathies. 2. rev., enl. ed.

    International Nuclear Information System (INIS)

    Forrai, J.

    1979-01-01

    Radiology plays an important role in confirming the diagnosis of haemophilia, in solving differential diagnostic problems, in the indication of surgical intervention and in the care of haemophiliacs. A detailed and accurate description of the X-ray symptomatology is given in this monograph. The author tries to fit the single radiomorphological signs into the entire, long pathological process. (Auth.)

  12. Albert Einstein for beginners. 12. enl. and rev. ed.

    International Nuclear Information System (INIS)

    Karamanolis, Stratis

    2008-01-01

    He was called the most important jew since the birth of Christus. Others however believed however he has came like no other nearer to the gods. Thought is Albrt Einstein, the scientific work of him and especially his relativity theory has the world changed radically both in scientific and in political regard. The present 12th extended and strongly revised edition of the book, which came out firstly above 20 years ago and until today thousands of readers - young and old - has always enthused, describes not only the relativity theory but also the role, which Einstein played in the development of the first atomic bomb. A short biographical part mediates to the reader also something about the man Einstein

  13. Solid state theory. An introduction. 2. rev. and ext. ed.

    International Nuclear Information System (INIS)

    Roessler, Ulrich

    2009-01-01

    Solid-State Theory - An Introduction is a textbook for graduate students of physics and material sciences. It stands in the tradition of older textbooks on this subject but takes up new developments in theoretical concepts and materials which are connected with such path breaking discoveries as the Quantum-Hall Effects, the high-Tc superconductors, and the low-dimensional systems realized in solids. Thus besides providing the fundamental concepts to describe the physics of electrons and ions of which the solid consists, including their interactions and the interaction with light, the book casts a bridge to the experimental facts and opens the view into current research fields. (orig.)

  14. Diagnostic imaging of the hand. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Schmitt, Rainer; Lanz, Ulrich

    2015-01-01

    The book on diagnostic imaging of the hand covers the following issues: projection radiography, cinematography, MRT and CR arthrography, arthroscopy, arteriography, skeleton scintiscanning, sonography, computerized tomography, magnetic resonance tomography, anatomy of forearm and carpus, anatomy of metacarpus and fingers, carpal function and morphometry, postoperative X-ray diagnostic, growing hand skeleton, normative variants, malformations and deformities, trauma of the distal forearm, lesions of the ulnocarpal complex (TFCC), scaphoid fractures, scaphoid arthrosis, fractures of other carpus bones, carpal luxations and luxation fractures, carpal instabilities, fractures of the metacarpalla, finger fractures, arthrosis deformans, enthesiopathies, sport induced soft tissue lesions, osteonecrosis, impingement syndromes, osteopenic skeletal diseases, metabolis diseases, crystal-induced osteoarthropaties, rheumatoid arthritis, spondyloarthritis, rheumatic fever, collagenoses, infective arthritis, osteomyelitis, soft tissue infections, cystoids bone lesions, skeletal tumors, soft tissue tumors, carpal tunnel syndrome, nerve compression syndrome, arterial perfusion disturbances, differential diagnostic tables on hand lesions.

  15. Ensemble-based Probabilistic Forecasting at Horns Rev

    DEFF Research Database (Denmark)

    Pinson, Pierre; Madsen, Henrik

    2009-01-01

    forecasting methodology. In a first stage, ensemble forecasts of meteorological variables are converted to power through a suitable power curve model. This modelemploys local polynomial regression, and is adoptively estimated with an orthogonal fitting method. The obtained ensemble forecasts of wind power...

  16. Quantum mechanics. Vol. 1. 4. rev. upd. ed.

    International Nuclear Information System (INIS)

    Cohen-Tannoudji, Claude; Diu, Bernard; Laloe, Franck

    2009-01-01

    The translation of the known French work of Nobel-price winner Cohen-Tannoudji and his co-authors Diu and Laloe introduces studyings of physics and natural sciences into the terms of quantum mechanics. After the positive acception of the first three editions of this textbook in German language the work now appears in fourth revised and improved edition. Each chapter consists of two parts. In the first part the basic postulates and terms are presented and developed. Teh second part - the supplements - mediates by means of numerous exercise problems and examples the handling of the basic quantum-mechanical knowledge. By this the work is at the same time a text and exercise book, which also, in the occupational praxis is useful as reference book

  17. MRT of the locomotor system. 4. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Vahlensieck, Martin; Reiser, Maximilian

    2015-01-01

    The book on MRT of the locomotor system covers the following topics: relevant NMT imaging techniques, spinal cord, shoulder, elbows, wrist and fingers, hip region, knee, lower leg - ankle - foot, temporomandibular joint, skeletal muscles, bone marrow, bone and soft tissue tumors, osteoporosis, sacroiliac joint, jaw and periodontium.

  18. Why did the experts go wrong? 3. rev. ed.

    International Nuclear Information System (INIS)

    Karcev, V.P.; Chazanovskij, P.M.

    1990-01-01

    The accidents which happened in the recent past (the Challenger explosion, the Chernobyl reactor accident, the Admiral Nachimow-Piotr Wassew collision and the Zeebrugge ferry accident) show that an insufficient human rather than an insufficient technical reliability is responsible for the grave accidents and catastrophes which haunt the high-technology age. Catastrophes cannot be avoided unless exaggerated euphoric or anti-technology views are replaced by responsible human action based on the latest scientific and technical knowledge. (orig./BBR) [de

  19. Environmental protection technology. 4. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Foerstner, U.

    1993-01-01

    The book deals on a broad basis with subjects related to environmental pollution. Both ecological and economic aspects are covered; technical means of avoiding and remedying environmental damage are discussed. Included are also an ethical evaluation and the legal aspects of the environmental pollution problem. (UT). 120 figs [de

  20. Stable isotope geochemistry. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Hoefs, J.

    1987-01-01

    Stable Isotope Geochemistry is an authoritative book comprising theoretical and experimental principles; surveying important fractionation mechanisms affecting the most important elements; discussing the natural variations of geologically important reservoirs. This updated 3rd edition, with a completely rewritten and extended main part, contains two new chapters on stable isotope composition of mantle material and on changes of the ocean during the geological past. (orig.)

  1. Solar building construction. Town planning - construction planning. 2. rev. ed.

    International Nuclear Information System (INIS)

    Schempp, D.; Krampen, M.; Moellring, F.

    1994-01-01

    The book discusses the problems of solar energy use under the following aspects: Town planing; Typology of green solar architecture; Typologie of solar architecture; Vegetation in green solar architecture; Planning and simulation; Building materials; Ventilation, illumination; Research projects. (HW) [de

  2. Ion Beam Synthesis of Ge Nanowires. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, T.

    2001-01-01

    The formation of Ge nanowires in V-grooves has been studied experimentally as well as theoretically. As substrate oxide covered Si V-grooves were used formed by anisotropic etching of (001)Si wafers and subsequent oxidation of their surface. Implantation of 1 x 10{sup 17} Ge{sup +}cm{sup -2} at 70 keV was carried out into the oxide layer covering the V-grooves. Ion irradiation induces shape changes of the V-grooves, which are captured in a novel continuum model of surface evolution. It describes theoretically the effects of sputtering, redeposition of sputtered atoms, and swelling. Thereby, the time evolution of the target surface is determined by a nonlinear integro-differential equation, which was solved numerically for the V-groove geometry. A very good agreement is achieved for the predicted surface shape and the shape observed in XTEM images. Surprisingly, the model predicts material (Si, O, Ge) transport into the V-groove bottom which also suggests an Ge accumulation there proven by STEM-EDX investigations. In this Ge rich bottom region, subsequent annealing in N{sub 2} atmosphere results in the formation of a nanowire by coalescence of Ge precipitates shown by XTEM images. The process of phase separation during the nanowire growth was studied by means of kinetic 3D lattice Monte-Carlo simulations. These simulations also indicate the disintegration of continuous wires into droplets mediated by thermal fluctuations. Energy considerations have identified a fragmentation threshold and a lower boundary for the droplet radii which were confirmed by the Monte Carlo simulation. The here given results indicate the possibility of achieving nanowires being several nanometers wide by further growth optimizations as well as chains of equally spaced clusters with nearly uniform diameter. (orig.)

  3. Turbomachinery. Vol. 1. Design and function. 6. rev. ed.

    International Nuclear Information System (INIS)

    Bohl, W.

    1994-01-01

    The basic technical manual contains the following main chapters: Main operating data of turbomachinery, energy conversion in the rotor, model laws and characteristics, cavitation, supersonic limit, water turbines, gas turbines, rotary pumps, fans, blowers, compressors, hydrodynamic couplings and transmissions, and operational behaviour of turbomachinery (performance characteristics). Basic knowledge in mathematics, fluid mechanics, thermodynamics, and technical mechanics is required to understand the subject matter. Little use is made of differential calculus and integral calculus. (orig.) [de

  4. Neurology check list. 5. rev. and enl. ed.; Checkliste Neurologie

    Energy Technology Data Exchange (ETDEWEB)

    Grehl, Holger [Evangelisches und Johanniter Klinikum, Duisburg (Germany). Neurologische Klinik; Reinhardt, Frank

    2013-02-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  5. Physics and radiology for nursing staff. 3. rev. ed.

    International Nuclear Information System (INIS)

    Goretzki, G.

    1984-01-01

    As nurses working in hospitals and surgeries as well as other assistants regularly operate technical equipment, it is essential to explain the physical basics in a form which is comprehensible to them. The author has managed to give a very clear portrayal of each area of physics with close reference to its application in medicine, partly with the use of simplified models. His portrayal extends from the make-up of the material to atomic and nuclear physics and covers mechanics, heat and electricity theory, optics and acoustics. The explanation is completed by sections on radiography and radiation protection. (orig.) [de

  6. Hydrotreater/Distillation Column Hazard Analysis Report Rev. 2

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, Peter P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wagner, Katie A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-04-15

    This project Hazard and Risk Analysis Report contains the results of several hazard analyses and risk assessments. An initial assessment was conducted in 2012, which included a multi-step approach ranging from design reviews to a formal What-If hazard analysis. A second What-If hazard analysis was completed during February 2013 to evaluate the operation of the hydrotreater/distillation column processes to be installed in a process enclosure within the Process Development Laboratory West (PDL-West) facility located on the PNNL campus. The qualitative analysis included participation of project and operations personnel and applicable subject matter experts. The analysis identified potential hazardous scenarios, each based on an initiating event coupled with a postulated upset condition. The unmitigated consequences of each hazardous scenario were generally characterized as a process upset; the exposure of personnel to steam, vapors or hazardous material; a spray or spill of hazardous material; the creation of a flammable atmosphere; or an energetic release from a pressure boundary.

  7. International Field Reversible Thermal Connector (RevCon) Challenge

    Science.gov (United States)

    2016-07-01

    direct metal laser sintering (DMLS) is chosen to fabricate the sophisticated wedge surfaces with...University 1st Prototype: MissStateU delivered a laser metal direct sintering (LMDS) piece, with oscillating heat pipes embedded in the device. The device...University DMLS direct metal laser sintering GIT Georgia Institute of Technology LMDS laser metal direct sintering MissStateU Mississippi

  8. Relative Hazard and Risk Measure Calculation Methodology Rev 1

    International Nuclear Information System (INIS)

    Stenner, Robert D.; White, Michael K.; Strenge, Dennis L.; Aaberg, Rosanne L.; Andrews, William B.

    2000-01-01

    Documentation of the methodology used to calculate relative hazard and risk measure results for the DOE complex wide risk profiles. This methodology is used on major site risk profiles. In February 1997, the Center for Risk Excellence (CRE) was created and charged as a technical, field-based partner to the Office of Science and Risk Policy (EM-52). One of the initial charges to the CRE is to assist the sites in the development of ''site risk profiles.'' These profiles are to be relatively short summaries (periodically updated) that present a broad perspective on the major risk related challenges that face the respective site. The risk profiles are intended to serve as a high-level communication tool for interested internal and external parties to enhance the understanding of these risk-related challenges. The risk profiles for each site have been designed to qualitatively present the following information: (1) a brief overview of the site, (2) a brief discussion on the historical mission of the site, (3) a quote from the site manager indicating the site's commitment to risk management, (4) a listing of the site's top risk-related challenges, (5) a brief discussion and detailed table presenting the site's current risk picture, (6) a brief discussion and detailed table presenting the site's future risk reduction picture, and (7) graphic illustrations of the projected management of the relative hazards at the site. The graphic illustrations were included to provide the reader of the risk profiles with a high-level mental picture to associate with all the qualitative information presented in the risk profile. Inclusion of these graphic illustrations presented the CRE with the challenge of how to fold this high-level qualitative risk information into a system to produce a numeric result that would depict the relative change in hazard, associated with each major risk management action, so it could be presented graphically. This report presents the methodology developed to produce the graphic illustrations showing the relative hazard and risk reductions that occur as a result of a site's projected risk management actions. The evaluation of relative hazard values is described and illustrated first (Sections 2 and 3) followed by the risk measure evaluations (Sections 4 and 5)

  9. Interactions of the tropical oceans. Rev.ed.

    International Nuclear Information System (INIS)

    Latif, M.; Barnett, T.P.

    1994-01-01

    We have investigated the interactions of the tropical oceans on interannual time scales by conducting a series of uncoupled atmospheric and oceanic general circulation experiments and hybrid coupled model simulations. Our results illustrate the key role of the El Nino/Southern Oscillation (ENSO) phenomenon in generating interannual variability in all three tropical ocean basins. Sea surface temperature (SST) anomalies in the tropical Pacific force via a changed atmospheric circulation SST anomalies of the same sign in the Indian Ocean and SST anomalies of the opposite sign in the Atlantic. However, although air-sea interactions in the Indian and Atlantic Oceans are much weaker than those in the Pacific, they contribute significantly to the variability in these two regions. The role of these air-sea interactions is mainly that of an amplifyer by which the ENSO induced signals are enhanced in ocean and atmosphere. This process is particularly important in the tropical Atlantic region. We investigated also whether ENSO is part of a zonally propagating ''wave'' which travels around the globe with a time scale of several years. Consistent with observations, the upper ocean heat content in the various numerical simulations seems to propagate slowly around the globe. SST anomalies in the Pacific Ocean introduce a global atmospheric response which in turn forces variations in the other tropical oceans. Since the different oceans exhibit different response characteristics to low-frequency wind changes, the individual tropical ocean responses can add up coincidentally to look like a global wave, and that appears to be the situation. In particular, no evidence is found that the Indian Ocean can significantly affect the ENSO cycle in the Pacific. Finally, the potential for climate forecasts in the Indian and Atlantic Oceans appears to be enhanced if one includes, in a coupled way, remote influences from the Pacific. (orig.)

  10. Introduction into technical application of fracture mechanics. 3. rev. ed.

    International Nuclear Information System (INIS)

    Heckel, K.

    1991-01-01

    Technical components made out of metal material are liable to be defective. Cracks are the most dangerous defects. Based on fracture mechanics methods were developed which permit to estimate the proveness of cracks to intrate fracture. The present book is restricted to the standardised methods of fracture mechanics. Theoretical foundations of various concepts aspect under the fracture mechanics are given. Experimental methods of determining material characteristics of fracture mechanics are explained in detail as a profound knowledge of testing criteria is necessary in order to be able to a characteristic to a component. This book contains the latest level of standardised methods of fracture mechanics. It is meant for advanced students and engineers working in practice. Some fully calculated examples are used as an introduction into the thinking of fracture mechanics. (orig./MM) [de

  11. Schering dictionary of radiology. 3. tot. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Zink, C.

    2005-01-01

    Sixteen years after the first edition, the new edition takes account of the dramatic developments in medical imaging. All entries have been revised, and the number of entries has been increased considerably. Special attention was given to magnetic resonance tomography and the many options of image-assisted interventions. Modern methods of nuclear medical diagnosis and radiotherapy were considered as well as new legal regulations on radiation protection. More entries dealing with clinical medicine and instructive case studies enable readers to get an even closer view at radiology in theory and practice. (orig.)

  12. Nuclear medicine. 4. new rev. and enl. ed.; Nuklearmedizin

    Energy Technology Data Exchange (ETDEWEB)

    Kuwert, T. [Universitaetsklinikum Erlangen (Germany). Nuklearmedizinische Klinik; Gruenwald, F. [Klinikum der Johann-Wolfgang-Goethe-Univ., Frankfurt (Germany). Klinik fuer Nuklearmedizin; Haberkorn, U. [Universitaetsklinikum Heidelberg (Germany). Abt. Nuklearmedizin; Krause, T. (eds.) [Universitaetsklinik Bern (Switzerland). Dept. Radiologie, Neuroradiologie und Nuklearmedizin

    2008-07-01

    The book on nuclear medicine is devided in three chapters: fundamentals, diagnostics and therapy. The topics within these chapters are the following: 1) fundamentals: molecular imaging; radiation physics, measuring technology and quality control; dosimetry and radiation effects; radiation protection, radiopharmaceutical chemistry; immonoassays and quality control. 2) diagnostics: endocrine organs; oncology; heart, vascular system and blood vessels; brain, lungs, skelton, kidneys, gastrointestine tract; infections; hematology. 3) radiotherapy; radiosynoviorothese; palliative bone pain therapy; radioimmunotherapy; {sup 1}31I-MIBG therapy; therapy with receptor affine peptides; specific nuclear medical therapies.

  13. CLINICAL APPLICATION OF TUMOUR MARKERS: A REvIEw

    African Journals Online (AJOL)

    2009-12-02

    Dec 2, 2009 ... for use in treatment monitoring of colorectal, hepatocellular, prostatic, ovarian and pancreatic carcinomas ... for cancer in the clinical setting (1,3-6). Primary ... presentation is one of the determinants of prognosis in cancer. If a tumour marker concentration is related to the tumour size then it may be useful for.

  14. National Ignition Facility risk management plan, rev. 1

    International Nuclear Information System (INIS)

    Brereton, S J; Lane, M A

    1998-01-01

    The initial release of the National Ignition Facility (AUF) Risk Management Plan (LLNL, 1997a) was prepared in accordance with the DOE Life Cycle Asset Management Good Practice Guide (DOE, 1996a) and supported Critical Decision 3 (CD3), Approval to Initiate Construction (DOE, 1997a). The objectives of the plan were to: (1) Identify the risks to the completion of the Project in terms of meeting technical and regulatory requirements, cost, and schedule. (2) Assess the risks in terms of likelihood of occurrence and their impact potential relative to technical performance, ES and H (environmental, safety and health), costs, and schedule. (3) Address suitable risk mitigation measures for each identified risk. This revision of the Risk Management Plan considers project risks and vulnerabilities after CD3 (DOE, 1997a) was approved by the Secretary of Energy. During the one-year period since the initial release, the vulnerabilities of greatest concern have been the litigation of the Programmatic Environmental Impact Statement (PEIS) (DOE, 1996b) by a group of environmental organizations led by the Natural Resources Defense Council; the finding and successful clean-up of polychlorinated biphenyl (PCB)-filled electrical capacitors at the NIF site excavation; the FY98 congressional budget authorization and request for the FY99 budget authorization; funding for Inertial Confinement Fusion (ICF)/NIF programmatic activities (including French and other sources of funding); and finally, progress in the core science and technology, and optics program that form the basis for the NIF design

  15. Nuclear suicide. Rev. ed. [FRG]. Der atomare Selbstmord

    Energy Technology Data Exchange (ETDEWEB)

    Gruhl, H

    1988-01-01

    The author, one of the most consistent opponents of nuclear power, strikes a balance after the Chernobyl catastrophe. He relentlessly analyses the 'German nuclear situation', developments to be expected from risks and catastrophic events. He exposes statements offered by the owners of power plants and by politicians as attempts to play risks down, and hopes to achieve a turnabout yet. The conjunction of technical and physical arguments with a fundamental criticism of the ideology of economic growth is what distinguishes this book from other publications critical of nuclear energy. But the author does not content himself with criticism, he goes on to point out realistic measures for opting out of nuclear energy. (orig./HSCH) With 10 figs. and maps.

  16. Experimental Plan for EDF Energy Creep Rabbit Graphite Irradiations- Rev. 2 (replaces Rev. 0 ORNL/TM/2013/49).

    Energy Technology Data Exchange (ETDEWEB)

    Burchell, Timothy D [ORNL

    2014-07-01

    The experimental results obtained here will assist in the development and validation of future models of irradiation induced creep of graphite by providing the following data: Inert creep stain data from low to lifetime AGR fluence Inert creep-property data (especially CTE) from low to lifetime AGR fluence Effect of oxidation on creep modulus (by indirect comparison with experiment 1 and direct comparison with experiment 3 NB. Experiment 1 and 3 are not covered here) Data to develop a mechanistic understanding, including oAppropriate creep modulus (including pinning and high dose effects on structure) oInvestigation of CTE-creep strain behavior under inert conditions oInformation on the effect of applied stress/creep strain on crystallite orientation (requires XRD) oEffect of creep strain on micro-porosity (requires tomography & microscopy) This document describes the experimental work planned to meet the requirements of project technical specification [1] and EDF Energy requests for additional Pre-IE work. The PIE work is described in detail in this revision (Section 8 and 9).

  17. Studies on Neotropical Phasmatodea XVI: Revision of Haplopodini Günther, 1953 (rev. stat.), with notes on the subfamily Cladomorphinae Bradley & Galil, 1977 and the descriptions of a new tribe, four new genera and nine new species (Phasmatodea: "Anareolatae": Phasmatidae: Cladomorphinae).

    Science.gov (United States)

    Hennemann, Frank H; Conle, Oskar V; Perez-Gelabert, Daniel E

    2016-06-27

    The anareolate New World subfamily Cladomorphinae Bradley & Galil, 1977 is reviewed and keys to the six tribes currently included are presented; these are: Cladomorphini Bradley & Galil, 1977, Cladoxerini Karny, 1923, Cranidiini Günther, 1953, Pterinoxylini n. trib., Hesperophasmatini Bradley & Galil, 1977 and Haplopodini Günther, 1953 rev. stat.. New diagnoses are presented for all these tribes and possible relationships within Cladomorphinae are discusssed. Morphology of the genitalia and egg-structures indicate Cladomorphinae as presently treated to be polyphyletic. Two subordinate groups are recognized within present Cladomorphinae, which differ considerably in numerous morphological characters of the insects and eggs. The first group and here regarded as Cladomorphinae sensu stricto is formed by the mostly South American Cladomorphini + Cranidiini + Cladoxerini, while the second group is formed by the predominantly Caribbean Hesperophasmatini + Pterinoxylini n. trib. + Haplopodini.        Members of the first group (= Cladomorphini sensu stricto) share the dorsally carinate basitarsus in which the two dorsal carinae are melted with another, increasingly elongated gonapophyses VIII of females which are noticeably longer than gonapophyses IX and lamellate as well as strongly displaced medioventral carina of the profemora. Cranidiini + Cladomorphini share the strongly elongated and filiform gonapophyses VIII and presence of gonoplacs in the females, specialized poculum of males and presence of a median line in the eggs. Cranidiini differs from all other tribes of Cladomorphinae by the entirely unarmed legs of both sexes, distinctly broadened and leaf-like body and prominent longitudinal keel of the mesosternum of females, prominently enlarged poculum and spinulose phallus of males as well as the conspicuous narrowing of the posteromedian gap of the internal micropylar plate of the eggs and noticeably separated median line. Cladomorphini is characteristic

  18. Eğitim Fakültelerinde Görev Yapmakta Olan Öğretim Elemanlarının Çokkültürlü Yeterlik Algılarının İncelenmesi Examining Multicultural Competence Perceptions of Education Faculty

    Directory of Open Access Journals (Sweden)

    Alper BAŞBAY

    2013-03-01

    ıduyulmasını sağlayacak biçimde ortak anlaşma çerçevesinde inşaedilmesi temel beklentidir. Özellikle ilköğretim ve ortaöğretimkurumlarında çalışan öğretmenlerin farklı kültürel özelliklere sahipöğrencilerine yönelik etkin bir çokkültürlü eğitim ortamı oluşturmasıgerektiği kaçınılmaz bir olgudur. Bu bağlamda öğretmen adaylarınıyetiştiren Eğitim Fakültelerinde görev yapmakta olan öğretimelemanlarının çokkültürlülüğe ilişkin bakış açılarının ortaya konulmasıgerekmektedir. Bu araştırmada Türkiye’deki üniversitelerin EğitimFakültelerinde görev yapmakta olan öğretim elemanlarının algıladıklarıçokkültürlü farkındalık, bilgi ve beceri düzeyleri ve bu yeterlikdüzeylerinin cinsiyet, unvan, iş deneyimi, yurtdışı deneyimi, yaşantınınçoğunun geçirildiği yer ve üniversitelerinin bulunduğu coğrafi bölgedeğişkenlerine göre anlamlı farklılıklar gösterip göstermediğiincelenmiştir. Çalışmaya 63 Eğitim Fakültesinden 176’sı kadın ve 171’ierkek olmak üzere toplam 347 öğretim elemanı katılmıştır.Araştırmanın verileri “Çokkültürlü Yeterlik Algıları Ölçeği” iletoplanmıştır. Verilerin analizinde çok değişkenli ANOVA (MANOVAkullanılmıştır. Araştırmanın sonuçlarına göre Eğitim Fakültelerindegörev yapmakta olan öğretim elemanlarının çokkültürlü bilgi,farkındalık ve beceri yeterlik algılarının yüksek olduğu görülmüştür.Araştırmanın diğer bulgularına göre öğretim elemanlarının çokkültürlüyeterlik algılarında unvan, iş deneyimi, yaşantının çoğunun geçirildiğiyer ve üniversitelerinin bulunduğu coğrafi bölge değişkenlerine göreanlamlı farklılıklar bulunamamışken, cinsiyet ve yurtdışı deneyimolmak üzere iki demografik değişken yönünden istatistiksel olarakanlamlı farklılıklar görülmüştür. Kadın öğretim elemanlarının kültürelfarkındalık ve beceri düzeylerinin erkek

  19. İlköğretim Okullarında Görev Yapan Öğretmenlerin Örgütsel Sinizm Düzeylerinin Belirlenmesi (Uşak İli Örneği Assessment of Cynicism Level of Primary School Teachers (Uşak Sample

    Directory of Open Access Journals (Sweden)

    Mehmet Akif HELVACI

    2012-09-01

    neticilerin sinizminin sebep ve sonuçlarını bilmeleri örgütteki başarı ve var ise sinizmin olumsuz sonuçlarını en etkili ve en uygun bir şekilde yönetme imkanı vermektedir. Örgütsel sinizmi etkileyen faktörlerin bilinmesi ya da algılanması yöneticilerin bu konuda duyarlı olup olumsuz sonuçlar doğurabilecek adım atmalarına engel olmaktadır. Bu araştırma, Uşak ili Milli Eğitim Bakanlığı’na bağlı kamu ilköğretim okullarında görev yapan öğretmenlerin örgütsel sinizm düzeylerini belirlemek amacıyla yapılmıştır. Aynı zamanda öğretmenlerin örgütsel sinizm düzeylerinin cinsiyet, branş, kıdem, öğrenim durumu, okulda çalışma süresi değişkenlerine göre faklılaşıp farklılaşmadığı saptanmak istenmiştir. Araştırma 2010-2011 eğitim-öğretim yılında yürütülen betimsel tarama modelinde bir çalışmadır. Araştırmanın evreni Uşak ili sınırları içerisinde bulunan tüm kamu ilköğretim okullarında görev yapan öğretmenlerden oluşmaktadır. Örneklemini ise tesadüfi örnekleme yolu ile seçilen 311 öğretmen oluşturmaktadır. Veri toplama aracı olarak Apaydın (2012 tarafından geliştirilen örgütsel sinizm ölçeği kullanılmıştır. Araştırma bulguları ilköğretim öğretmenlerin sinizm algılarının “Az düzeyinde” olduğunu göstermektedir. İlköğretim öğretmenlerinin sinizme ilişkin görüşleri cinsiyet, branş, kıdem, öğrenim durumu bakımından değişmemektedir. Okuldaki çalışma süresi bakımından, bulunduğu okulda 6-10 yıl çalışan öğretmenlerin, 1-5 yıl çalışan öğretmenlere göre daha çok sinizme sahip olduklarını göstermektedir.

  20. Offshore wind turbines Horns Rev. Evaluation of effects on the environment. (VVM) - VVM statement[Denmark]; Havmoeller Horns Rev. Vurdering af virkninger paa miljoeet. VVM-redegoerelse

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-05-01

    Several environmental investigations have been carried out, which provide the basis for the environmental descriptions and evaluations in this environmental impact statement. The environmental impact statement follows in its construction these instructions: The offshore wind turbine array; An alternative siting of the offshore wind turbine array and alternative landing points of the cable trace; The area and the surroundings, where the offshore wind turbine array might be sited and the area, where the landing cable might be placed; The consequences for the environment resulting from the offshore wind turbine array and the establishing and operation phase of the cable plant; The measures, which might be used to reduce any harmful effects on the environment; Proposal for succeeding measuring and monitoring program; A survey of short comings of the information and the evaluation of the environmental impact. (EHS)

  1. OECD MMCI Small-Scale Water Ingression and Crust Strength tests (SSWICS) SSWICS-1 final data report, Rev. 1 February 10, 2003.; Report, Rev. 1

    International Nuclear Information System (INIS)

    Lomperski, S.; Farmer, M.T.; Kilsdonk, D.; Aeschlimann, B.

    2011-01-01

    The Melt Attack and Coolability Experiments (MACE) program at Argonne National Laboratory addressed the issue of the ability of water to cool and thermally stabilize a molten core/concrete interaction (MCCI) when the reactants are flooded from above. These tests provided data regarding the nature of corium interactions with concrete, the heat transfer rates from the melt to the overlying water pool, and the role of noncondensable gases in the mixing processes that contribute to melt quenching. However, due to the integral nature of these tests, several questions regarding the crust freezing behavior could not be adequately resolved. These questions include: (1) To what extent does water ingression into the crust increase the melt quench rate above the conduction-limited rate and how is this affected by melt composition and system pressure; and (2) What is the fracture strength of the corium crust when subjected to a thermal-mechanical load and how does it depend upon the melt composition? A series of separate-effects experiments are being conducted to address these issues. The first employs an apparatus designed to measure the quench rate of a pool of corium (∼φ30 cm; up to 20 cm deep). The main parameter to be varied in these quench tests is the melt composition since it is thought to have a critical influence on the crust cracking behavior which, in turn, alters quench rate. The issue of crust strength will be addressed with a second apparatus designed to mechanically load the crust produced by the quench tests. This apparatus will measure the fracture strength of the crust while under a thermal load created by a heating element beneath the crust. The two apparatuses used to measure the melt quench rate and crust strength are jointly referred to as SSWICS (Small-Scale Water Ingression and Crust Strength). This report describes results of the first water ingression test, designated SSWICS-1. The test investigated the quench behavior of a 15 cm deep, fully oxidized PWR corium melt containing 8 wt% limestone/common sand concrete decomposition products. The melt was quenched at nominally atmospheric pressure. The report includes a description of the test apparatus, the instrumentation used, plots of the recorded data, and data reduction to obtain an estimate of the corrected heat flux from the corium to the overlying water pool. A section of the report is devoted to calculations of the conduction-limited heat flux that accounts for heat losses to the crucible holding the corium. The remainder of the report describes post test examinations of the crust, which includes permeability and mechanical strength measurements, and chemical analysis.

  2. Nevada Test Site Waste Acceptance Criteria (NTSWAC), Rev. 7-01

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Management

    2009-05-01

    This document establishes the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, Nevada Test Site Waste Acceptance Criteria (NTSWAC). The NTSWAC provides the requirements, terms, and conditions under which the Nevada Test Site (NTS) will accept low-level radioactive waste and mixed low-level waste for disposal. The NTSWAC includes requirements for the generator waste certification program, characterization, traceability, waste form, packaging, and transfer. The criteria apply to radioactive waste received at the NTS Area 3 and Area 5 Radioactive Waste Management Complex for disposal.

  3. Orientation guide for imaging examinations. Recommendation of the radiation protection commission. 2. rev. ed.

    International Nuclear Information System (INIS)

    2012-01-01

    Due to the wide range of medical diagnostic method that include partially high radiation exposures of the patients (for instance CT examinations) the mean radiation exposure of the public is increasing in Germany. In 2006 the German Strahlenschutzkommission (radiation protection commission) has published a catalogue for the different diagnostic questions including recommendations for the best imaging technique. This orientation guide was actualized in 2012. The catalogue is aimed to avoid unnecessary radiation exposure and to simultaneously improve the medical diagnostics. Nevertheless the applying physician has to justify and document the selected diagnostic technique for the individual case. The guide covers the following issues: head, neck, spinal cord, skeleton and muscles, cardiovascular system, thorax, digestive system, urogenital tract, gynecology, mammary glands, trauma, oncology, pediatrics, interventional radiology.

  4. Computed tomography of the head and spinal cord. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Hosten, N.; Liebig, T.

    2007-01-01

    This is an everyday reference manual for routine diagnosis and also for critical situations; it is a reliable vademecum for all radiologists, neurologists and neurosurgeons. It contains all information that is required for CT diagnosis of the skull and spinal cord. Detailed information on normal anatomy and standard reference values enable the practician to differentiate between normal and pathological findings. There is a clear and didactically useful structure with sections on pathogenesis, clinical findings and CT morphology for each clinical picture. (orig.)

  5. A guide to radiologic methods of diagnosis. 9. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Thurn, P.; Buecheler, E.; Frommhold, H.

    1992-01-01

    With the 9th edition of this guide an attempt was made to take account of technical innovations in radiology and the appropriate range of indications. Attention was mainly focused on the various possibilities offered at the clinical level by high-resolution computed tomography as well as nmr imaging and digitized radiography. The chapter on radioprotection and radiation injuries has been rewritten and updated through the addition of recently prepared tables. The clinical chapters chiefly deal with the roles of nmr imaging and computed tomography. This applies in particular to discussions relating to the central nervous system, facial skull, cervical region and soft tissues. Radiologic methods of intervention were given some coverage. The chapter on contrast media and mishaps attributable to these was completely revised. (orig./MG) With 761 figs., 29 tabs [de

  6. Inhibition of HIV-1 in vitro by C-5 propyne phosphorothioate antisense to rev

    DEFF Research Database (Denmark)

    Lund, O S; Nielsen, Jens Ole; Hansen, J E

    1995-01-01

    in a sequence-dependent manner. The antiviral effect was obtained by lipofection or simple addition of 0.2-1 microM modified oligodeoxynucleotide to the culture medium of H9 cells chronically infected with the HIV-1LAI isolate of human immunodeficiency virus type 1. We conclude that C-5 propyne...

  7. Focusing errors in radiography - how they can be recognized and avoided. 2. rev. ed.

    International Nuclear Information System (INIS)

    Zimmer, E.A.; Zimmer-Brossy, M.

    1979-01-01

    The importance of the problem of recognizing and judging focusing errors for the daily practice has caused the authors to give this systematic and abundantly pictured account of the most frequent focusing errors, for as yet no such book has been published either in Germany or abroad. To keep it as concise and handy as possible the authors have restricted themselves to the most important standard pictures and omitted to list errors such as: blurred pictures owing to breathing or movement as well as under and overexposed pictures, which are easy to recognize and avoid. By contrast, they describe in detail those characteristic points and lines of orientation that must be checked to verify the technical quality of an X-ray picture. Knowledge of the typical aspects in a correctly focused X-ray picture is a precondition for understanding incorrectly focused pictures which have some characteristic properties as well. Proper interpretation of an incorrectly focused picture then permits to detect also the cause of the focusing error, be it false centring or false positioning. Thus quick and aimed correction becomes possible. To avoid unnecessary repeat X-rays, which are self-prohibitive for reasons of radiation protection alone, each chapter contains at the end a remark starting in which cases the medical indication requires the repetition of an unserviceable X-ray. (orig./ORU) [de

  8. Regulations for the safe transport of radioactive materials. 1973 rev. ed

    International Nuclear Information System (INIS)

    1973-01-01

    The purpose of these Regulations is to establish standards of safety which provide an acceptable level of control of the radiation hazards to persons, property and the environment that are associated with the transport of radioactive material. These Regulations shall apply to the transport by land, water or air, including transport on own account, of radioactive material other than that which is an integral part of the means of transport. Transport shall be deemed to include any operation incidental to the whole course of carriage, such as loading, unloading and storage in transit. The term includes both normal transport and that under accident conditions. These Regulations do not apply within establishments where the radioactive material is produced, used or stored, other than in the course of transport, and in respect of which other appropriate safety regulations are in force. In the transport of radioactive materials, any other hazardous characteristics of these materials such as explosiveness, inflammability, pyrophoricity, chemical toxicity, and corrosiveness must be taken into account in such a manner as to be in compliance with the relevant transport regulations for dangerous goods of each of the countries through or into which the materials will be transported, as well as in compliance with these Regulations.

  9. Safety analysis report for the TRUPACT-II shipping package (condensed version). Volume 1, Rev. 14

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-01

    The condensed version of the TRUPACT-II Contact Handled Transuranic Waste Safety Analysis Report for Packaging (SARP) contains essential material required by TRUPACT-II users, plus additional contents (payload) information previously submitted to the U.S. Nuclear Regulatory Commission. All or part of the following sections, which are not required by users of the TRUPACT-II, are deleted from the condensed version: (i) structural analysis, (ii) thermal analysis, (iii) containment analysis, (iv) criticality analysis, (v) shielding analysis, and (vi) hypothetical accident test results.

  10. Disaster medicine. A guide for medical care in case of disasters. 4. rev. ed.

    International Nuclear Information System (INIS)

    1997-01-01

    This is the fourth edition of a vademecum for medical experts in the Federal Republic of Germany, published by the Civil Defence Commission, an advisory body of the Federal Ministry of the Interior. The booklet is to help to provide and organize medical care in case of disasters, panic, mass injuries, radiation damage, poisoning and epidemics. There is a separate chapter on radiation accidents and radiation disasters as well as an appendix with a glossary of radiological terms and a list of radiation protection centers. (orig/MG) [de

  11. It comes with the territory handling problem situations in libraries, rev ed

    CERN Document Server

    Turner, Anne M

    2004-01-01

    ""Practical...useful""--Booklist; ""order this book immediately...interesting...entertaining and educational...outstanding...timely and useful--a must for all sizes and types of libraries""--Library Journal; ""good...recommended""--Public Libraries; ""Turner has revised and updated this classic guidebook that provides creative and sensible ways for handling sticky situations in public libraries""--SRRT Newletter; ""highly recommended""--Public Services Quarterly; ""well written...engaging...very helpful and timely""--Reference Quarterly

  12. C14-Crash. The C14-method and dendrochronology, unveiling the illusion. 2. rev. ed.

    International Nuclear Information System (INIS)

    Bloess, C.; Niemitz, H.U.

    2000-01-01

    In this second edition of the book, which was published almost three years after the first edition, the authors reiterate and substantiate their doubts as to the basic theories underlying the radiocarbon dating method and the applicability of dendrochronology. (orig/CB) [de

  13. Wind energy utilisation. 7. enl. and compl. rev. ed.; Nutzung der Windenergie

    Energy Technology Data Exchange (ETDEWEB)

    Heier, Siegfried [Kassel Univ. (Germany)

    2016-07-01

    The use of wind energy register furthermore rapid technological advances. Intensive research efforts in scientific institutions and in industry have led to it that the plants are reliable high technology products today. An overview of these developments give the completely revised BINE reference-book. The focus is on technologies, concepts and the market development of the wind industry. Other topics include network integration, economy and current research perspectives as well as environmental balance and repowering. Planners, investors and students get an overview of the status and development of the technology, the economy and the legal framework. [German] Die Nutzung der Windenergie verzeichnet weiterhin rasante technologische Fortschritte. Intensive Forschungsanstrengungen an wissenschaftlichen Institutionen und in der Industrie haben dazu gefuehrt, dass die Anlagen heute zuverlaessige Hightech Produkte sind. Einen Ueberblick ueber diese Entwicklungen gibt das vollstaendig ueberarbeitete BINE-Fachbuch. Im Mittelpunkt stehen Technologien, Konzepte und die Marktentwicklung der Windbranche. Weitere Themen sind die Netzintegration, Wirtschaftlichkeit und aktuelle Forschungsperspektiven sowie Umweltbilanz und Repowering. Planer, Investoren und Studierende erhalten einen Ueberblick ueber Stand und Entwicklung der Technik, die Wirtschaftlichkeit sowie die rechtlichen Rahmenbedingungen.

  14. Carriage of radioactive materials subject to the law concerning transport of dangerous goods. 3. rev. ed.

    International Nuclear Information System (INIS)

    Vogt, H.W.; Falkhof, W.

    1994-01-01

    The third ordinance amending the Ordinance Concerning the Carriage of Dangerous Good by Road (GGVS) introduces two regulatory requirements of major importance to the transportation trade: (1) The carrier has to provide for specific training of the drivers, and is to employ only reliable drivers. (2) The driver has to give proof of a specific training for transport of dangerous goods. In order to give carriers time to get abreast with the new instructions, the following time frame has been defined: - As from July 1, 1991, GGVS training (ADR license) mandatory for drivers of vehicles bigger than 38 t of max. perm. total weight, subject to identification provisions, and of vehicles subject to identification provisions carrying materials of classes 1 and 7, -as from January 1, 1993, GGVS training (ARD license) mandatory for drivers of vehicles bigger than 7.5 t of max, perm. total weight, subject to identification provisions, - as from January 1, 1995 GGVS training (ADR license) mandatory for drivers of vehicles bigger than 3.5 t of max perm. total weight, subject to identification provisions. The textbook for the training courses covers: 1. General instructions. 2. General particulars of risks. 3. Documentation. 4. Labelling and classification. 5. Vehicle types and modes of carriage, packaging, equipment. 6. Performance of transport. 7. Obligations and responsibilities, penalties. 8. Measures to be taken in case of accidents or incidents. (orig./HP) [de

  15. Advanced Simulation and Computing Fiscal Year 14 Implementation Plan, Rev. 0.5

    Energy Technology Data Exchange (ETDEWEB)

    Meisner, Robert [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McCoy, Michel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Archer, Bill [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Matzen, M. Keith [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2013-09-11

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of experimental facilities and programs, and the computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources that support annual stockpile assessment and certification, study advanced nuclear weapons design and manufacturing processes, analyze accident scenarios and weapons aging, and provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is now focused on increasing predictive capabilities in a three-dimensional (3D) simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (sufficient resolution, dimensionality, and scientific details), quantify critical margins and uncertainties, and resolve increasingly difficult analyses needed for the SSP. Moreover, ASC’s business model is integrated and focused on requirements-driven products that address long-standing technical questions related to enhanced predictive capability in the simulation tools.

  16. The impact of wind direction in atmospheric BL on interacting wakes at Horns Rev wind farm

    DEFF Research Database (Denmark)

    Ivanell, Stefan; Mikkelsen, Robert Flemming; Sørensen, Jens Nørkær

    2010-01-01

    coefficients. The ad- vantage of using the actuator-disc technique is that it is not necessary to resolve blade boundary layers since the computational resources are devoted to simulating the dynamics of the flow structures. In the present study approximately 13.6 million mesh points are used to resolve...... developed computer code Ellip-Sys3D with the actuator-disc methodology. In the actuator-disc method the blades are represented by a disc at which body forces representing the aerodynamic loading are introduced. The body forces are determined by computing local angles of attack and tabulated aerofoil...

  17. Godiva IV and Juliet Diagnostics CED-1, Rev. 1 (IER-176)

    Energy Technology Data Exchange (ETDEWEB)

    Scorby, J C; Myers, W L

    2012-04-11

    The Juliet experiment is currently in preliminary design (IER-128). This experiment will utilize a suite of diagnostics to measure the physical state of the device (temperature, surface motion, stress, etc.) and the total and time rate of change of neutron and gamma fluxes. A variety of potential diagnostics has been proposed in this CED-1 report. Based on schedule and funding, a subset of diagnostics will be selected for testing using the Godiva IV pulsed reactor as a source of neutrons and gammas. The diagnostics development and testing will occur over a two year period (FY12-13) culminating in a final set of diagnostics to be fielded for he Juliet experiment currently proposed for execution in FY15.

  18. Reference Design Description for a Geologic Repository, Rev. 03, ICN 02

    International Nuclear Information System (INIS)

    Gerald Shideler

    2001-01-01

    One of the current major national environmental problems is the safe disposal of large quantities of spent nuclear fuel and high-level radioactive waste materials, which are rapidly accumulating throughout the country. These radioactive byproducts are generated as the result of national defense activities and from the generation of electricity by commercial nuclear power plants. At present, spent nuclear fuel is accumulating at over 70 power plant sites distributed throughout 33 states. The safe disposal of these high-level radioactive materials at a central disposal facility is a high national priority. This Reference Design Description explains the current design for a potential geologic repository that may be located at Yucca Mountain in Nevada for the disposal of spent nuclear fuel and high-level radioactive waste materials. This document describes a possible design for the three fundamental parts of a repository: a surface facility, subsurface repository, and waste packaging. It also presents the current conceptual design of the key engineering systems for the final four phases of repository processes: operations, monitoring, closure, and postclosure. In accordance with current law, this design does not include an interim storage option. In addition, this Reference Design Description reviews the expected long-term performance of the potential repository. It describes the natural barrier system which, together with the engineered systems, achieves the repository objectives. This design will protect the public and the environment by allowing the safe disposal of radioactive waste received from government-owned custodial spent fuel sites, high-level radioactive waste sites, and commercial power reactor sites. All design elements meet or exceed applicable regulations governing the disposal of high-level radioactive waste. The design will provide safe disposal of waste materials for at least a 10,000 year period. During this time interval, natural radioactive decay of the waste materials will result in fission products that pose a minimal radiological hazard to the public afterward. For example, after 100 years, the relative hazard from the waste fission products will have diminished approximately 90 percent. After 1,000 years, the hazard will have diminished 99 percent, and after 10,000 years it will have diminished 99.9 percent. The resulting radiological hazard after 10,000 years is minimal, being of the same order of magnitude as that posed by 0.2 percent uranium ore, which is equivalent to that which was used to originally produce the nuclear fuel. Because developing such a repository is extremely complex, the design will move forward in three stages: Site Recommendation, License Application, and Construction. This document presents the design as it will be submitted in the Site Recommendation Consideration Report; the design will be updated as the design process moves forward. As more cost-effective solutions, technical advancements, or changes to requirements occur, the design may evolve. The U.S. Department of Energy's (DOE) Office of Civilian Radioactive Waste Management is developing a system that includes this potential repository. This waste management system integrates acceptance, transportation, storage, and disposal of spent nuclear fuel and high-level radioactive waste. Acceptance and transportation will be handled by regional servicing contractors under contract to the DOE. The U.S. Nuclear Regulatory Commission will conduct an in-depth and thorough licensing review to determine the acceptability of the proposed waste management system. Eight sections of this document follow. Section 2 discusses the design requirements for the proposed repository. Section 3 describes the physical layout of the proposed repository. Section 4 describes the evolutionary phases of the development of the proposed repository. Section 5 describes the receipt of waste. Section 6 details the various systems that will package the waste and move it below ground, as well as safety monitoring and closure. Section 7 describes the systems (natural and engineered) that ensure continued safety after closure. Section 8 offers design options that may be adopted in the future, and Section 9 provides a summary statement on the repository. The design work for the engineering systems described in this document was accomplished using established engineering practices and state-of-the-art technology. Technical design work and scientific activities described in this document were conducted in accordance with quality assurance/quality control requirements outlined in the DOE Quality Assurance Requirements and Description document and its associated implementing procedures

  19. Energy conversion in engines and machines. 7. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Kalide, W.

    1989-01-01

    In view of the modern engineers training methods in which the emphasis is laid on basic training, the book is a profound and easily understandable introduction to the complex field of energy conversion. First a simple introduction is given to the physical fundamentals of thermodynamics and fluid dynamics. The technical processes in piston engines and turbomachinery are explained with particular regard to a comprehensible and physically correct description of the energy conversion processes. Engines are discussed at length, due to the fact that knowledge on primary and secondary energy conversion is an important part of engineers training in this age of energy crises. Types of engines and machines are presented according to their present importance. The new edition covers further some environmental problems, as waste heat, noise and air pollution. (orig./GL) With 313 figs., 11 tabs [de

  20. The concept of time in physics. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Mittelstaedt, P.

    1980-01-01

    In this book the notion of time in classical physics and relativity theory is discussed. After a criticism of the absolute time some alternative measures of time in mechanics are considered. Thereafter the problem of equal time at different points of the space as well as the time in different inertial systems are considered. In this framework the clock paradoxon is discussed. Then the Lorentz transformation is considered. Thereafter the reconstruction of the absolute time in relativity theory is described. Finally the notion of time in general relativity theory is considered. (HSI)

  1. Metallurgical aspects of welding. Ferrous and nonferrous materials. 4. new rev. ed.

    International Nuclear Information System (INIS)

    Schulze, Guenter

    2010-01-01

    This is the fourth edition of the standard work on welding metallurgy. The various problems of ferrous and nonferrous materials in the welding process are presented in great detail. In order to prevent corrosion of welded constructions, metallurgical properties and problems of all important technical materials are discussed, i.e. alloyed and unalloyed steels, cast iron materials, and the most relevant nonferrous materials. At the end of each chapter, the interested reader will find exercises for self-studies. Some of these can be solved using the material presented in the book while others are intended for deepening and further training. Easy examples (with solutions) are found all over the book; they are helpful because they provide information on underlying mechanisms and interdependences that are not obvious at first glance. The information was adapted to new EURO standards and international standards (up to March 2009) as far as these are relevant to Germany. New information is provided, e.g., on new steel standards (constructional steels according to DIN EN 10025), heat-treatable steels according to DIN EN 10025-6 and DIN EN 10083, high-alloy steels according to DIN EN 10088, and filler materials for steel welding according to DIN EN ISO 2560. The systematics of the ''law of cohabitation'' was applied to welding engineering for the first time here. (orig.) [de

  2. Page 1 Rev. Sci. Technol., Synthese 26: 57 - 64 (2013) D. Ali ...

    African Journals Online (AJOL)

    Une augmentation de la teneur en proline est observee dans les plantes traitees ou non par !'hormone la kinetine. Mots cles: ... hormone in plants under stress induced a proportional increase in chlorophyll (a) and (b) with the concentration of used salt. ..... grains and vegetables, Agronomy Journal, Vol. 66,. 412-421.

  3. Second Line of Defense: Electronic Maintenance Reports, Local Maintenance Provider User Guide, Rev. 3

    Energy Technology Data Exchange (ETDEWEB)

    Leigh, Richard J.

    2012-09-01

    The Electronic Maintenance Report forms allow Local Maintenance Providers (LMP) and other program staff to enter maintenance information into a simple and secure system. This document describes the features and information required to complete the Maintenance Report forms. It is expected that all Corrective Maintenance Reports from LMPs will be submitted electronically into the SLD Portal. As an exception (e.g., when access to the SLD Portal is unavailable), Maintenance Reports can be submitted via a secure Adobe PDF form available through the Sustainability Manager assigned to each country.

  4. A study on maintenance rule program and its application to Korean NPP - Rev.1

    International Nuclear Information System (INIS)

    Hwang, Mee Jeong; Kim, Kil Yoo; Yang, Joon Eon; Ha, Jae Joo

    2001-03-01

    The objective of the Maintenance Rule is to require monitoring of the overall continuing effectiveness of licensee maintenance programs to ensure that safety related and certain nonsafety-related SSCs are capable of performing their intended functions and, for nonsafety-related equipment failures will not occur that prevent the fulfillment of safety-related functions, and failures resulting in scrams and unnecessary actuations of safety-related systems are minimized. That is, proper maintenance is essential to plant safety. U.S. Maintenance Rule, which was effective July 1996 in USA., was not officially adopted in Korea by Korean regulatory body. However, since many PSA and IPE have been performed for NPPs, the philosophy and usefulness of the Maintenance Rule as well as performance-based regulation are being acceptable. We survey the Maintenance Rule program and applications in the USA, and also developed the Maintenance Rule program to apply to Korean NPPs. In addition, we applied the Maintenance Rule Program apply to Ulchin 3,4 Units roughly with the Maintenance Rule Program developed in this project

  5. Pediatric chest imaging. Chest imaging in infants and children. 2. rev. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Lucaya, Javier [Vall d' Hebron Hospitals, Barcelona (Spain). Dept. of Pediatric Radiology and Inst. of Diagnostic Imaging; Hospital Quiron, Barcelona (Spain). Dept. of Radiology; Strife, Janet L. (eds.) [Cincinnati Univ. Coll. of Medicine, Cincinnati, OH (United States). Dept. of Radiology Cincinnati Children' s Hospital Medical Center

    2008-07-01

    Imaging of the pediatric chest continues to evolve rapidly. All chapters in this 2nd edition of Pediatric Chest Imaging have been extensively updated, with additional disease-specific information and numerous new illustrations. The book thus presents the state of the art in the diagnosis of pediatric chest disorders, highlighting the role played by advanced technology. As the conventional features of most of these disorders are extremely well known, special attention is devoted to the technical aspects of the modern imaging modalities, their indications, and the diagnostic information that they supply. Individual chapters focus on chest ultrasound, nuclear medicine imaging, high-resolution chest CT, helical CT, and pediatric cardiac CT and pediatric cardiacMRI. Others are directed towards specific disorders, including congenital malformations of the chest, chest tumors, pulmonary infection, trauma, the lung in systemic diseases, the pediatric airway, foreign bodies, the thymus, and the chest wall. Without exception, the authors of this book are internationally known specialists with great expertise in the field. This book will serve as a handy, superbly illustrated reference for all who routinely image children, as well as for those who need access to information on how best to image them. (orig.)

  6. MRT of abdomen and pelvis. 2. tot. rev. and enl. ed.; MRT von Abdomen und Becken

    Energy Technology Data Exchange (ETDEWEB)

    Hamm, B.; Krestin, G.P. (eds.); Laniado, M.; Nicolas, V.; Taupitz, M.

    2007-07-01

    The book offers maximum expert knowledge from an experienced team of authors, first-class reference image material, clear guidelines for indications and actions also in comparison with other techniques, and a detailed presentation of examination sequences with table protocols. There are clear schematic drawings, guidelines, key findings and tables for differential diagnosis, and a list of possible misinterpretations. The authors present contributions on MR angiography and examination of infants and take account of all modern trends and indications. The book facilitates introduction to the subject, reading-up, and quick reference. It provides practical support at the workplace and is written in a user-friendly manner. There is a new chapter ''rectum'', and the book contains more than 1000 illustrations. (orig.)

  7. Radiotherapy and radiooncology: An interdisciplinary approach. 4. tot. new rev. and enl. ed.

    International Nuclear Information System (INIS)

    Karstens, J.H.; Bremer, M.; Meyer, A.; Warszawski, A.; Bruns, F.

    2005-01-01

    This is the 4th, completely revised edition of the successful book on modern cancer therapy. The focus of this edition is on interdisciplinary cooperation. Current knowledge, both legal and medical, is presented in a clear and well-structured form. The text is supplemented by many illustrative drawings and pictures. The book addresses students and other readers interested in oncology and provides useful and detailed information on radiation therapy of benign and malignant diseases. (orig.)

  8. Technical dictionary power plant engineering. Vol. 1. 4. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    1987-01-01

    This dictionary is a compilation of German and English technical terms of power plant engineering as far as power plants, turbine-generators and assembly engineering are concerned. It is the result of a joint effort by the Kraftwerk Union AG (KWU) and Utility Power Corp. (UPC). The entire content has been revised and approx. 6000 new terms have been added. The dictionary is meant to form a basis for uniform terminology on technical documents as well as correspondence between KWU, UPC and licensees. This computer aided dictionary is printed in capital/low case letters. Only nouns, terms with an article and proper names are capitalized in German. Some terms are written differently in American and British English and are marked with (US) or (GB). (orig./HP) [de

  9. Power plant engineering dictionary. Vol. 2. 4. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    1987-01-01

    The dictionary is a compilation of 6000 German and English technical terms of power plant engineering as far as power plants, turbine-generators and assembly engineering are concerned. It is meant to form a basis for uniform terminology on technical documents. The dictionary is the result of a joint effort of KWU and UPC. (DG)

  10. Creating Joint Leaders Today for a Successful Air Force Tomorrow (1REV)

    Science.gov (United States)

    2016-04-01

    military goals must be comprised of personnel who are trained, educated, experienced, and acculturated in jointness.P 32F15P In order to achieve...less stress on the organization with regard to constant turnover at the senior leader level. URecommendation 5:U Adopt a modified Navy model of

  11. The Swedish electricity market and the role of Svenska Kraftnaet (rev. ed.)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-11-01

    At the end of the year 1995, the Swedish electricity market was reformed. The reform chiefly entailed the production and sale of electricity being separated from the transmission of electricity (the network operation). Electricity production and trading were exposed to competition - while the network operation was retained as a natural monopoly. In this publication, we describe the extensive developments that have taken place during the last ten years on an electricity market that was previously relatively static. We also deal with Svenska Kraftnaet's role in this context. The Swedish electricity market consists of many independent players. These are: electricity producers; network owners; the system operator (Svenska Kraftnaet); electricity consumers; electricity traders in the role of electricity suppliers; and/or balance providers; marketplaces, primarily the power exchange NordPool. Svenska Kraftnaet owns the national grid and has the role of System Operator. This means ensuring that the plants of the Swedish electricity system are working together in an operationally-reliable way and that production and import corresponds to consumption and export. The regional networks transmit electricity from the grid to the local networks, and in some cases to large-scale consumers. The local networks distribute electricity to the consumers within a certain geographical area. For connection and transmission, the consumer pays a network fee (network account). The Power Trading Company sells electricity to the final customers. The power trader can have the role of Electricity Supplier and/or Balance Provider. Both roles can exist within the same or different companies. The electricity supplier has a supply agreement with the consumer. The balance provider is financially responsible for the electricity that the trader sells always being in balance with the electricity purchased to cover consumption. Organised marketplaces, for example the power exchange Nord Pool, as well as brokers, provide standard agreements which make it easier for the players on the market to do business with each other. The bulk of the trade in electricity on the market takes place via bilateral agreements between electricity producers and electricity traders. The possibility to supervise the network operation is central to the electricity market being able to work well, as well as preventing the network companies from abusing their monopoly position. The Swedish National Energy Administration is the network authority, and is responsible for this supervision. It must ensure that the network tariffs are reasonable and that the network operation does not subsidise other activities. A separate licence - the supply concession - was initially introduced. Companies obtaining such a concession - the supply concessionaires - were obligated to supply electricity to consumers not wishing to change supplier. During the autumn of 1998, parliament adopted adjustments to the Electricity Act in accordance with the European Parliament's and the European Council's directive regarding joint rules for the internal electricity market, known as the Electricity Market Directive. In October 1999, parliament decided to abolish the requirement for hourly meters for the majority of consumers, and introduce profile-settlement of consumption instead. The system of supply concessions was abolished at the same time. This had the effect of making it financially viable also for small-scale consumers to buy electricity on the open market. The legislative changes came into force on 1 November 1999. Svenska Kraftnaet is a utility charged with managing and operating Sweden's national grid and overseas links. The grid encompasses the country's 400 and 220 kV power lines. Svenska Kraftnaet is also the System Operator under the Electricity Act. This entails having the overall responsibility for electrical plants working together in an operationally-reliable way so that a state of balance between the production and consumption of electricity can be maintained throughout the country. Svenska Kraftnaet's objectives are; offering reliable, efficient and environmentally-adapted transmission of electricity on the grid, promoting an open and competitive Nordic electricity market, discharging its system responsibility cost-effectively and working for a robust and flexible electricity supply during times of crisis and war. Svenska Kraftnaet and Statnett - which has the system responsibility in Norway - jointly own the Nordic power exchange, Nord Pool, with headquarters in Oslo. Svenska Kraftnaet and Finnish system operator Fingrid jointly own a smaller power exchange for balance adjustment, EL-EX, located in Helsinki. Nord Pool and EL-EX work closely together - among other things acting as agents for each other's products, which complement one another. A decision has been taken to merge Nord Pool spot market and EL-EX to form a new company - Nord Pool Nordic Elspot - (abstract truncated)

  12. AGR-2 Irradiation Test Final As-Run Report, Rev 2

    Energy Technology Data Exchange (ETDEWEB)

    Collin, Blaise P. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-08-01

    This document presents the as-run analysis of the AGR-2 irradiation experiment. AGR-2 is the second of the planned irradiations for the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program. Funding for this program is provided by the U.S. Department of Energy as part of the Very High Temperature Reactor (VHTR) Technical Development Office (TDO) program. The objectives of the AGR-2 experiment are to: (a) Irradiate UCO (uranium oxycarbide) and UO2 (uranium dioxide) fuel produced in a large coater. Fuel attributes are based on results obtained from the AGR-1 test and other project activities. (b) Provide irradiated fuel samples for post-irradiation experiment (PIE) and safety testing. (c) Support the development of an understanding of the relationship between fuel fabrication processes, fuel product properties, and irradiation performance. The primary objective of the test was to irradiate both UCO and UO2 TRISO (tri-structural isotropic) fuel produced from prototypic scale equipment to obtain normal operation and accident condition fuel performance data. The UCO compacts were subjected to a range of burnups and temperatures typical of anticipated prismatic reactor service conditions in three capsules. The test train also includes compacts containing UO2 particles produced independently by the United States, South Africa, and France in three separate capsules. The range of burnups and temperatures in these capsules were typical of anticipated pebble bed reactor service conditions. The results discussed in this report pertain only to U.S. produced fuel. In order to achieve the test objectives, the AGR-2 experiment was irradiated in the B-12 position of the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for a total irradiation duration of 559.2 effective full power days (EFPD). Irradiation began on June 22, 2010, and ended on October 16, 2013, spanning 12 ATR power cycles and approximately three and a half calendar years. The test contained six independently controlled and monitored capsules. Each U.S. capsule contained 12 compacts of either UCO or UO2 AGR coated fuel. No fuel particles failed during the AGR-2 irradiation. Final burnup values on a per compact basis ranged from 7.26 to 13.15% FIMA (fissions per initial heavy-metal atom) for UCO fuel, and 9.01 to 10.69% FIMA for UO2 fuel, while fast fluence values ranged from 1.94 to 3.47 x 1025 n/m2 (E >0.18 MeV) for UCO fuel, and from 3.05 to 3.53 x 1025 n/m2 (E >0.18 MeV) for UO2 fuel. Time-average volume-average (TAVA) temperatures on a capsule basis at the end of irradiation ranged from 987°C in Capsule 6 to 1296°C in Capsule 2 for UCO, and from 996 to 1062°C in UO2-fueled Capsule 3. By the end of the irradiation, all of the installed thermocouples (TCs) had failed. Fission product release-to-birth (R/B) ratios were quite low. In the UCO capsules, R/B values during the first three cycles were below 10-6 with the exception of the hotter Capsule 2, in which the R/Bs reached 2 x 10-6. In the UO2 capsule (Capsule 3), the R/B values during the first three cycles were below 10-7. R/B values for all following cycles are not reliable due to gas flow and cross talk issues.

  13. AGR-1 Irradiation Test Final As-Run Report, Rev. 3

    Energy Technology Data Exchange (ETDEWEB)

    Collin, Blaise P. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-01-01

    This document presents the as-run analysis of the AGR-1 irradiation experiment. AGR-1 is the first of eight planned irradiations for the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program. Funding for this program is provided by the US Department of Energy (DOE) as part of the Next-Generation Nuclear Plant (NGNP) project. The objectives of the AGR-1 experiment are: 1. To gain experience with multi-capsule test train design, fabrication, and operation with the intent to reduce the probability of capsule or test train failure in subsequent irradiation tests. 2. To irradiate fuel produced in conjunction with the AGR fuel process development effort. 3. To provide data that will support the development of an understanding of the relationship between fuel fabrication processes, fuel product properties, and irradiation performance. In order to achieve the test objectives, the AGR-1 experiment was irradiated in the B-10 position of the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) for a total duration of 620 effective full power days of irradiation. Irradiation began on December 24, 2006 and ended on November 6, 2009 spanning 13 ATR cycles and approximately three calendar years. The test contained six independently controlled and monitored capsules. Each capsule contained 12 compacts of a single type, or variant, of the AGR coated fuel. No fuel particles failed during the AGR-1 irradiation. Final burnup values on a per compact basis ranged from 11.5 to 19.6 %FIMA, while fast fluence values ranged from 2.21 to 4.39 x 1025 n/m2 (E >0.18 MeV). We’ll say something here about temperatures once thermal recalc is done. Thermocouples performed well, failing at a lower rate than expected. At the end of the irradiation, nine of the originally-planned 19 TCs were considered functional. Fission product release-to-birth (R/B) ratios were quite low. In most capsules, R/B values at the end of the irradiation were at or below 10-7 with only one capsule significantly exceeding this value. A maximum R/B of around 2 x 10-7 was reached at the end of the irradiation in Capsule 5. Several shakedown issues were encountered and resolved during the first three cycles. These include the repair of minor gas line leaks; repair of faulty gas line valves; the need to position moisture monitors in regions of low radiation fields for proper functioning; the enforcement of proper on-line data storage and backup, the need to monitor thermocouple performance, correcting for detector spectral gain shift, and a change in the mass flow rate range of the neon flow controllers.

  14. Sc, Y, La-Lu. Rare earth elements. Vol. A 6a. 8. rev. ed.

    International Nuclear Information System (INIS)

    Ditz, R.; Sarbas, B.; Schubert, P.; Toepper, W.

    1988-01-01

    The present volume 'Rare Earth Elements' A 6a describes origin, mode of occurrence, and behavior of Y and RE elements in the sedimentary and metamorphic cycles, and completes the series of volumes describing cosmo- and geochemistry of these elements. In the chapter 'Sedimentary Cycle', the behavior of Y and RE during the weathering process is first outlined under both marine and terrestrial conditions, including a short compilation for migration and precipitation in surficial weathering and oxidation zones. The main part of the chapter treats, in addition to the mode of occurrence, predominantly the distribution of Y and RE in the different types of sedimentary rocks in relation to genetic processes (comprising physical and/or spatial factors such as geological age of the deposition). A concluding part gives a description of mobilization, migration, and precipitation of Y and RE during the diagenetic transformation of sediments, especially in relation to the various types of ferromanganese concretions. In the chapter 'Metamorphic Cycle', the first, extensive part gives examples of mode of occurrence and behavior of Y and RE during both the contact-metamorphic and prograde and retrograde regional-metamorphic processes affecting sedimentary and igeneous source rocks. The second part briefly describes behaviour of Y and RE during ultrametamorphism of metamorphic rocks, and during metamorphic processes in connection with special types of geologic events (as, e.g., subduction of crustal material into the earth's mantle and impact of extraterrestrial material). (orig.) With 4 figs

  15. HLW Melter Control Strategy Without Visual Feedback VSL-12R2500-1 Rev 0

    Energy Technology Data Exchange (ETDEWEB)

    Kruger, A A. [Department of Energy, Office of River Protection, Richland, Washington (United States); Joseph, Innocent [The Catholic University of America, Washington, DC (United States); Matlack, Keith S. [The Catholic University of America, Washington, DC (United States); Callow, Richard A. [The Catholic University of America, Washington, DC (United States); Abramowitz, Howard [The Catholic University of America, Washington, DC (United States); Pegg, Ian L. [The Catholic University of America, Washington, DC (United States); Brandys, Marek [The Catholic University of America, Washington, DC (United States); Kot, Wing K. [The Catholic University of America, Washington, DC (United States)

    2012-11-13

    Plans for the treatment of high level waste (HL W) at the Hanford Tank Waste Treatment and Immobilization Plant (WTP) are based upon the inventory of the tank wastes, the anticipated performance of the pretreatment processes, and current understanding of the capability of the borosilicate glass waste form [I]. The WTP HLW melter design, unlike earlier DOE melter designs, incorporates an active glass bubbler system. The bubblers create active glass pool convection and thereby improve heat and mass transfer and increase glass melting rates. The WTP HLW melter has a glass surface area of 3.75 m{sup 2} and depth of ~ 1.1 m. The two melters in the HLW facility together are designed to produce up to 7.5 MT of glass per day at 100% availability. Further increases in HL W waste processing rates can potentially be achieved by increasing the melter operating temperature above 1150°C and by increasing the waste loading in the glass product. Increasing the waste loading also has the added benefit of decreasing the number of canisters for storage.

  16. We experience more than we comprehend. Quantum physics and questions of life. rev. new ed.

    International Nuclear Information System (INIS)

    Duerr, Hans-Peter; Oesterreicher-Mollwo, Marianne

    2015-01-01

    The quantum physics has been arrived by thinking and experimenting to revolutioning knowledges, which determine our world, also if only few have understood these theories in their real sense. The present book follows the question, whether and how far a consciousness trained by quantum physics can reach more directly to the understanding of questions of life and religious questions than a thinking, which is obliged to classical physics. It deals especially with fundamental existential questions: The theme of personal responsibility, the value of the individual existence, the evaluation of the personal I-you relation. Hans Peter Duerr, a personality with guiding qualities, as they are necessary in the new millennium, is the ideal speech partner for the dimension of this theme. The connections of natural sciences and religion, ecology, and sociological change have always driven the Heisenberg successor. How can we speech about that, which science cannot comprehend?. What means self, identity, responsibility for the quantum physicist? An exciting meeting.

  17. Guidelines for system modeling: pre-accident human errors, rev.0

    International Nuclear Information System (INIS)

    Kang, Dae Il; Jung, W. D.; Lee, Y. H.; Hwang, M. J.; Yang, J. E.

    2004-01-01

    The evaluation results of Human Reliability Analysis (HRA) of pre-accident human errors in the probabilistic safety assessment (PSA) for the Korea Standard Nuclear Power Plant (KSNP) using the ASME PRA standard show that more than 50% of 10 items to be improved are related to the identification and screening analysis for them. Thus, we developed a guideline for modeling pre-accident human errors for the system analyst to resolve some items to be improved for them. The developed guideline consists of modeling criteria for the pre-accident human errors (identification, qualitative screening, and common restoration errors) and detailed guidelines for pre-accident human errors relating to testing, maintenance, and calibration works of nuclear power plants (NPPs). The system analyst use the developed guideline and he or she applies it to the system which he or she takes care of. The HRA analyst review the application results of the system analyst. We applied the developed guideline to the auxiliary feed water system of the KSNP to show the usefulness of it. The application results of the developed guideline show that more than 50% of the items to be improved for pre-accident human errors of auxiliary feed water system are resolved. The guideline for modeling pre-accident human errors developed in this study can be used for other NPPs as well as the KSNP. It is expected that both use of the detailed procedure, to be developed in the future, for the quantification of pre-accident human errors and the guideline developed in this study will greatly enhance the PSA quality in the HRA of pre-accident human errors

  18. Wood production for energy purposes in the agriculture. 4. rev. ed.; Energieholzproduktion in der Landwirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, Martin [Kompetenzzentrum HessenRohstoffe (HeRo) e.V., Witzenhausen (Germany)

    2010-07-01

    The cultivation of fast growing tree species such as poplars or willows in short harvesting periods is an extensive form of land use which increasingly is interesting with respect to the climate protection and development of the prices for fossil energy sources. Cultivation concepts have to be oriented towards the existing agrarian structure and the possible lines of utilization. This requires an answer of the following questions: (a) What has to be considered with the cultivation?; (b) Which tree species are recommended?; (c) Which procedures of harvesting do exist?; (d) How does economy present itself? The contribution under consideration tries to give answers to these questions. The contribution summarizes the actual state of knowledge from research and first practical cultivations. The contribution under consideration also dedicates itself to the practical farmer.

  19. Imaging of the head and neck. 2. rev. and enl. ed

    Energy Technology Data Exchange (ETDEWEB)

    Mafee, M.F.; Valvassori, G.E. [University of Illinois, Chicago, IL (United States); Becker, M. [Geneva University Hospital (Switzerland)

    2004-07-01

    Remarkable advances in medical diagnostic imaging have been made during the past three decades. The development of new imaging techniques and continuous improvements in the display of digital images have opened new horizons in the study of head and neck anatomy and pathology. The American Society of Head and Neck Radiology (ASHNR) and its European and Asiatic counterparts evolved because of the emerging awareness of the roles that head and neck radiologists play in the diagnosis and management of head and neck, base of the skull, neuro-ophthalmologic and neuro-otologic diseases. This edition continues the tradition of excellence set by the first edition of Valvassori's Head and Neck Imaging (which was also the first textbook in head and neck radiology), and provides a comprehensive review of the most pertinent and up-to-date knowledge in the field of head and neck imaging. The content of this edition has been organized into 12 chapters according to anatomic regions. It now includes new material on the temporomandibular joint, the lacrimal drainage system, dental scanning, fibro-osseous and cartilaginous lesions of the head and neck, MRI sialography, MR interventional technique, and thyroid and parathyroid glands. All chapters have been expanded to address new developments in the field and to stress the importance of imaging anatomy, pathologic correlation, and pertinent clinical data. For each anatomic region, the embryology and anatomy are introduced, followed by congenital and developmental disorders, inflammatory processes, benign and malignant neoplastic diseases, trauma, and postoperative changes. The detailed reference lists in each chapter include key references and are as recent as possible. Care has been taken to include exquisitely reproduced illustrations that provide the maximum of pertinent information. It is our hope that this textbook will be useful to students and physicians in the fields of radiology, otolaryngology, neurootology, rhinology, head and neck surgery, ophthalmology, neuroophthalmology, oromaxillofacial-temporomandibular surgery, neurology, neurosurgery, and oncology. (orig.)

  20. Production and utilization of biogas in rural areas of industrialized and developing countries. Rev. Ed

    Energy Technology Data Exchange (ETDEWEB)

    Eggeling, G; Mackensen, G; Sasse, L [comps.

    1986-01-01

    This handbook describes and compares the various phases of biogas technology and its parallel development in industrialized countries and developing nations for the given agricultural situation in each. Special emphasis is placed on the microbiological fundamentals of anaerobic fermentation, their technical application, examples of biogas systems in industrialized and emerging nations, cost efficiency and implementation. In their treatment of various common characteristics, parallels and differences, the authors have attempted to build a bridge between biogas practice in industrialized countries and biogas practice in developing countries.

  1. Greenhouse effect and CO2 emissions. 3. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Kuehr, W.

    1990-01-01

    The brochure is to prove that nuclear energy does not present a technology which would avoid the greenhouse effect. It is true that nuclear power plants do not produce CO 2 , but the production cycle includes ore mines, uranium enrichement, etc. where energy reguirements are met by fossil fuels, and this is where nuclear power plants pruduce CO 2 indirectly. Environmental and climate hazards can be influenced by economic and political decisions. It is important to reduce consumption, to promote renewable energy sources, and to replace nuclear as well as fossil fuels. (orig./HSCH) [de

  2. MaliSheep10R2 rev19JanAM

    International Development Research Centre (IDRC) Digital Library (Canada)

    funds research projects that aim to solve immediate and concrete food security challenges in the developing world. For more information on this project, contact innocent Butare. Dakar. Senegal (ibutare@idrc.org.sn) or Susan Robertson. Ottawa. Canada. (srobertson@idrc.ca). For more information on the Fund, visit ...

  3. Law of the energy economy. A practical manual. 4. new rev. ed.

    International Nuclear Information System (INIS)

    Schneider, Jens-Peter; Theobald, Christian

    2013-01-01

    This manual presents the laws governing the electricity and gas markets, a field that has evolved at ever greater speed since the onset of liberalisation. Its content is of practical relevance and well-founded, yet nonetheless readily comprehensible to the layman. Following introductory sections on the technical and economic as well as national and European foundations of energy law are a wealth of contributions offering detailed analyses of the regulation of market structures; planning and licensing of energy infrastructure and energy installations; granting of municipal concessions to energy supply companies; trade in energy and emission permits as well as grid operation and grid utilisation; energy regulatory authorities and procedures; promotion of renewable energy, cogeneration and energy saving. The manual consistently takes account of the relevant regulations of cartel, municipal, environmental, tax, contractual and financial market law. Links to energy law proper are duly covered wherever practically relevant. The following legislation in particular has been incorporated in this new edition: 2011 amendment to the Energy Economy Law (unbundling, transmission system operator, grid development plans, modernisation in metrology, new consumer rights); 2012 amendment to the Nuclear Energy Law; Grid Expansion Acceleration and Transmission System Law of 2011 (NABEG); Renewable Energy Law of 2012; and Cogeneration Law of 2012.

  4. The legal basis of natural gas distribution technology. 2. rev. ed.

    International Nuclear Information System (INIS)

    Ambos, G.; Bramkamp, F.B.; Rienen, W. van

    1993-01-01

    The body of legal regulations reaches from general power economy laws to technical safety and environmental laws as well as to laws on construction regulations. The legal regulations laid down by the European Community in regard to the creation of a European single market are of increasing significance. The book wants to give basic information on the relevant legal areas and makes it easier to understand the structure and the systematics of the laws on power supply technology. It does so by differentiating three areas: - Survey of the legal regulatory framework: - Depiction of the basis of energy laws and the questions which arise from the practical work of the energy control board: - Survey of the technical safety and emission control laws in regard to natural-gas distribution by public utilities. (orig.) [de

  5. AGR-2 irradiation test final as-run report, Rev. 1

    International Nuclear Information System (INIS)

    2014-01-01

    This document presents the as-run analysis of the AGR-2 irradiation experiment. AGR-2 is the second of the planned irradiations for the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program. Funding for this program is provided by the U.S. Department of Energy as part of the Very High Temperature Reactor (VHTR) Technical Development Office (TDO) program. The objectives of the AGR-2 experiment are to: (a) Irradiate UCO (uranium oxycarbide) and UO 2 (uranium dioxide) fuel produced in a large coater. Fuel attributes are based on results obtained from the AGR-1 test and other project activities; (b) Provide irradiated fuel samples for post-irradiation experiment (PIE) and safety testing; and, (c) Support the development of an understanding of the relationship between fuel fabrication processes, fuel product properties, and irradiation performance. The primary objective of the test was to irradiate both UCO and UO 2 TRISO (tri-structural isotropic) fuel produced from prototypic scale equipment to obtain normal operation and accident condition fuel performance data. The UCO compacts were subjected to a range of burnups and temperatures typical of anticipated prismatic reactor service conditions in three capsules. The test train also includes compacts containing UO 2 particles produced independently by the United States, South Africa, and France in three separate capsules. The range of burnups and temperatures in these capsules were typical of anticipated pebble bed reactor service conditions. The results discussed in this report pertain only to U.S. produced fuel. In order to achieve the test objectives, the AGR-2 experiment was irradiated in the B-12 position of the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for a total irradiation duration of 559.2 effective full power days (EFPD). Irradiation began on June 22, 2010, and ended on October 16, 2013, spanning 12 ATR power cycles and approximately three and a half calendar years. The test contained six independently controlled and monitored capsules. Each U.S. capsule contained 12 compacts of either UCO or UO 2 AGR coated fuel. No fuel particles failed during the AGR-2 irradiation. Final burnup values on a per compact basis ranged from 7.26 to 13.15% FIMA (fissions per initial heavy-metal atom) for UCO fuel, and 9.01 to 10.69% FIMA for UO 2 fuel, while fast fluence values ranged from 1.94 to 3.47x10 25 n/m 2 (E >0.18 MeV) for UCO fuel, and from 3.05 to 3.53x10 25 n/m 2 (E >0.18 MeV) for UO 2 fuel. Time-average volume-average (TAVA) temperatures on a capsule basis at the end of irradiation ranged from 987°C in Capsule 6 to 1296°C in Capsule 2 for UCO, and from 996 to 1062°C in UO 2 -fueled Capsule 3. By the end of the irradiation, all of the installed thermocouples (TCs) had failed. Fission product release-to-birth (R/B) ratios were quite low. In the UCO capsules, R/B values during the first three cycles were below 10 -6 with the exception of the hotter Capsule 2, in which the R/Bs reached 2x10 -6 . In the UO 2 capsule (Capsule 3), the R/B values during the first three cycles were below 10 -7 . R/B values for all following cycles are not reliable due to gas flow and cross talk issues.

  6. Introduction into thermodynamics. From elements to technical applications. 13. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Cerbe, G.; Hoffmann, H.J.

    2002-01-01

    This textbook has been proved for more than 30 years and has been regularly revised and updated. Thus, recent developments in energy conversion and environmental protection have constantly been taken into account. Tabulated values and standards reflect the current state of things. The book's basic concept was maintained without change from the first to the twelfth edition: leading over from well-founded thermodynamic theory to technical applications, closeness to practice because of many examples with solutions and tasks with solution results, the opportunity for self-study with 130 examples, 135 tasks and 175 control questions with answers, and high usability because of many tables and direct-information diagrams. The 13th edition was actualised and enhanced by combined-cycle power plants and fuel cells. (orig./GL) [de

  7. Developments in National Fuel Alcohol (biofuel) Programs: implications for world sugar trade. Rev. ed.

    International Nuclear Information System (INIS)

    1998-01-01

    This paper focuses on developments in the national fuel alcohol programmes of Brazil, the European Union and USA with the main emphasis on Brazil. A brief history of Brazil's alcohol production is given, and the deregulation of the alcohol sector in Brazil, the impacts of partial liberalisation of Brazil's alcohol sector, government delays in further liberalisation and attempts to manage supply, the PROALCOOL programme, the government's actions to boost ethanol demand, the slump in ethanol output in 1998/1999, and the increase in sugar output are examined. The long term goal of increasing reliance on biofuels in the European Union, the EU's alcohol industry, and ethanol production in France are considered. Market factors affecting ethanol production in the US, the US government's extension of its ethanol tax incentive, the US ethanol sector, and the future demand for ethanol in the US are discussed. The short and medium-term implications for sugar in Brazil, the EU and the US are assessed. (UK)

  8. Advanced Simulation and Computing FY10-FY11 Implementation Plan Volume 2, Rev. 0.5

    Energy Technology Data Exchange (ETDEWEB)

    Meisner, R; Peery, J; McCoy, M; Hopson, J

    2009-09-08

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future non-nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering (D&E) programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile assessment and certification, to study advanced nuclear weapons design and manufacturing processes, to analyze accident scenarios and weapons aging, and to provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is focused on increasing its predictive capabilities in a three-dimensional (3D) simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (focused on sufficient resolution, dimensionality and scientific details); to quantify critical margins and uncertainties (QMU); and to resolve increasingly difficult analyses needed for the SSP. Moreover, ASC has restructured its business model from one that was very successful in delivering an initial capability to one that is integrated and focused on requirements-driven products that address long-standing technical questions related to enhanced predictive capability in the simulation tools. ASC must continue to meet three objectives: (1) Robust Tools - Develop robust models, codes, and computational techniques to support stockpile needs such as refurbishments, SFIs, LEPs, annual assessments, and evolving future requirements; (2) Prediction through Simulation - Deliver validated physics and engineering tools to enable simulations of nuclear weapons performance in a variety of operational environments and physical regimes and to enable risk-informed decisions about the performance, safety, and reliability of the stockpile; and (3) Balanced Operational Infrastructure - Implement a balanced computing platform acquisition strategy and operational infrastructure to meet Directed Stockpile Work (DSW) and SSP needs for capacity and high-end simulation capabilities.

  9. Advanced Simulation and Computing FY09-FY10 Implementation Plan Volume 2, Rev. 1

    Energy Technology Data Exchange (ETDEWEB)

    Kissel, L

    2009-04-01

    The Stockpile Stewardship Program (SSP) is a single, highly integrated technical program for maintaining the surety and reliability of the U.S. nuclear stockpile. The SSP uses past nuclear test data along with current and future non-nuclear test data, computational modeling and simulation, and experimental facilities to advance understanding of nuclear weapons. It includes stockpile surveillance, experimental research, development and engineering programs, and an appropriately scaled production capability to support stockpile requirements. This integrated national program requires the continued use of current facilities and programs along with new experimental facilities and computational enhancements to support these programs. The Advanced Simulation and Computing Program (ASC) is a cornerstone of the SSP, providing simulation capabilities and computational resources to support the annual stockpile assessment and certification, to study advanced nuclear weapons design and manufacturing processes, to analyze accident scenarios and weapons aging, and to provide the tools to enable stockpile Life Extension Programs (LEPs) and the resolution of Significant Finding Investigations (SFIs). This requires a balanced resource, including technical staff, hardware, simulation software, and computer science solutions. In its first decade, the ASC strategy focused on demonstrating simulation capabilities of unprecedented scale in three spatial dimensions. In its second decade, ASC is focused on increasing its predictive capabilities in a three-dimensional simulation environment while maintaining support to the SSP. The program continues to improve its unique tools for solving progressively more difficult stockpile problems (focused on sufficient resolution, dimensionality and scientific details); to quantify critical margins and uncertainties (QMU); and to resolve increasingly difficult analyses needed for the SSP. Moreover, ASC has restructured its business model from one that was very successful in delivering an initial capability to one that is integrated and focused on requirements-driven products that address long-standing technical questions related to enhanced predictive capability in the simulation tools. ASC must continue to meet three objectives: (1) Robust Tools - Develop robust models, codes, and computational techniques to support stockpile needs such as refurbishments, SFIs, LEPs, annual assessments, and evolving future requirements; (2) Prediction through Simulation - Deliver validated physics and engineering tools to enable simulations of nuclear weapons performance in a variety of operational environments and physical regimes and to enable risk-informed decisions about the performance, safety, and reliability of the stockpile; and (3) Balanced Operational Infrastructure - Implement a balanced computing platform acquisition strategy and operational infrastructure to meet Directed Stockpile Work (DSW) and SSP needs for capacity and high-end simulation capabilities.

  10. Virginia Offshore Wind Technology Advancement Project (VOWTAP) DOE EE0005985 Final Technical Report Rev 1a

    Energy Technology Data Exchange (ETDEWEB)

    Pietryk, Steven [Dominion, Richmond, VA (United States)

    2017-01-31

    The primary purpose of the VOWTAP was to advance the offshore wind industry in the United States (U.S.) by demonstrating innovative technologies and process solutions that would establish offshore wind as a cost-effective renewable energy resource. The VOWTAP Team proposed to design, construct, and operate a 12 megawatt (MW) offshore wind facility located approximately 27 statute miles (mi) (24 nautical miles [nm], 43 kilometers [km]) off the coast of Virginia. The proposed Project would consist of two Alstom Haliade™ 150-6 MW turbines mounted on inward battered guide structures (IBGS), a 34.5-kilovolt (kV) alternating current (AC) submarine cable interconnecting the WTGs (inter-array cable), a 34.5-kV AC submarine transmission cable (export cable), and a 34.5 kV underground cable (onshore interconnection cable) that would connect the Project with existing Dominion infrastructure located in Virginia Beach, Virginia (Figure 1). Interconnection with the existing Dominion infrastructure would also require an onshore switch cabinet, a fiber optic cable, and new interconnection station to be located entirely within the boundaries of the Camp Pendleton State Military Reservation (Camp Pendleton). The VOWTAP balanced technology innovation with commercial readiness such that turbine operations were anticipated to commence by 2018. Dominion, as the leaseholder of the Virginia Wind Energy Area (WEA), anticipated leveraging lessons learned through the VOWTAP, and applying them to future commercial-scale offshore wind development.

  11. Energy in the residential building. Electricity, heat, e-mobility. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Schwarzburger, Heiko

    2017-01-01

    Photovoltaics, heat pumps and fuel cells offer enormous potential for sustainable energy supply in residential buildings. Solar thermal energy and wood-fired boilers also play an important role in refurbishment. Due to the wide range of possible combinations, the wishes of building owners and homeowners for an ecologically and economically individually adapted energy concept can be fulfilled accurately. This book provides you with a holistic approach to the residential building and its supply of electricity, heat and water. All processes that play a role in the house's energy consumption are examined in their entirety for their potentials and potential savings. The author analyses and describes in detail the resources of buildings and their surroundings - and how they can be used for a truly independent supply. The focus is on reducing energy consumption and costs, the generation and supply of energy from renewable sources and energy storage - considered in new construction and modernisation. The supply of water is also dealt with if it touches on energy issues. The author draws attention to standards and regulations and gives practical advice for planning and installation. The focus is on the so-called sector coupling: electricity from the sun, wind and hydrogen is used to supply electrical consumers in the home, charging technology for electric vehicles, hot water and heating. The time of the boilers and combustion engines has elapsed. Clean electricity and digital controls - power and intelligence - determine the regenerative building technology. [de

  12. Horns Rev 2 offshore wind farm photo case with wakes observed in 2016

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Nygaard, Nicolai Gayle; Volker, Patrick

    results from atmospheric WRF meso-scale modelling, Park wake model and large eddy simulation wake model are prepared and analysed. At the time of the photos a humid and warm air mass was advected from the southwest over cold sea. The dew-point temperature was such that cold-water advection fog formed...

  13. Maintenance manual. Vol. 1. Maintenance management; 2. completely rev. ed.; Handbuch Instandhaltung. Bd. 1. Instandhaltungsmanagement

    Energy Technology Data Exchange (ETDEWEB)

    Warnecke, H.J. [ed.] [Fraunhofer-Institut fuer Produktionstechnik und Automatisierung (IPA), Stuttgart (Germany)

    1992-12-31

    This manual is the second, completely revised edition of the standard manual ``Maintenance - Fundamentals``, which was first published in 1981. It presents an outline of all relevant fields of maintenance today and contains practical information on new and established methods of maintenance management and technology. With its comprehensive concept, which addresses any industrial enterprise that wants to remain competitive, the manual is indispensable for maintenance managers in industry, service enterprises and consultancies. Vol.1, ``Maintenance Management``, informs the reader on fundamentals, design with a view to maintenance, organisation of maintenance work, personnel management, industrial safety and economic aspects of maintenance. Current issues such as product liability, electronic data processing, expert systems, environmental protection, controlling based on characteristic data, etc. are gone into. Graphical representations, concrete procedural information and exemplary solutions may be used directly as working tools for the practice of maintenance. (orig.) [Deutsch] Das vorliegende Handbuch ist die zweite, voellig ueberarbeitete und erweiterte Auflage des Standardwerkes ``Instandhaltung - Grundlagen``, das 1981 erstmals erschien. Es gibt einen Ueberblick ueber alle relevanten Gebiete einer modernen Instandhaltung und vermittelt praxisnahes Wissen ueber neue und bewaehrte Methoden und Verfahren des Instandhaltungsmanagements und der Instandhaltungstechnik. Mit dieser umfassenden Konzeption, die auf die Belange des im Wettbewerb stehenden Industriebetriebes ausgerichtet ist, wendet sich das Handbuch an die Fuehrungskraefte der Instandhaltung in der Industrie sowie an Dienstleistungs- und Beratungsunternehmen. Im Band 1 ``Instandhaltungsmanagement`` kann sich der Leser ueber Grundlagen, instandhaltungsgerechtes Konstruieren, Organisation der Instandhaltung, Personalmanagement, Arbeitssicherheit sowie Wirtschaftlichkeit der Instandhaltung informieren. Aktuelle Themen wie Produkthaftung, EDV-Einsatz, Expertensystemen, Umweltschutz, kennzahlengestuetztes Controlling etc. wurden neu aufgenommen. Zahlreiche graphische Darstellungen, konkrete Handlungsanleitungen und Musterloesungen koennen als direkt anwendbare Arbeitshilfen fuer die betriebliche Instandhaltungspraxis eingesetzt werden. (orig.)

  14. Low Temperature Power Coating (LTPC) Phase 2 Laboratory Test Plan and Procedures for PACAF (Rev D)

    Science.gov (United States)

    2018-03-20

    Battelle 505 King Avenue Columbus, Ohio 43201 Submitted to: Mr. Jason G. McDuffie Technical Advisor , Support Equipment & Vehicles Division...LTPC projects, and a review of available technical literature. Panels will be sheared to a size of 4.0” x 6.0” and have a nominal thickness of 0.032

  15. Synthesis of a '4+1' Re(V) complex from Re(III), and its ...

    African Journals Online (AJOL)

    bis(2-hydroxybenzyl)-2-(2-aminoethyl)dimethylamine) was prepared from the oxidation of [ReCl3(MeCN)(PPh3)2] by dioxygen in the presence of H2had in ethanol. This reaction was done under reflux conditions for a relatively short reaction ...

  16. Bones - joints - soft tissues II. 7. rev. ed. Knochen - Gelenke - Weichteile II

    Energy Technology Data Exchange (ETDEWEB)

    Dihlmann, W. (Roentgeninstitut, Allgemeines Krankenhaus Barmbek, Hamburg (Germany)); Frommhold, W. (Radiologische Klinik, Tuebingen Univ. (Germany)) (eds.)

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs.

  17. Skeletal diseases. Diagnostic clinical radiology and differential diagnostics. 2. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Freyschmidt, J.

    1997-01-01

    The book focuses on the diagnostic evaluation of idiopathic diseases of the skeleton and bone joints, also including the fundamental healing processes of bone fractures, particularly of stress-induced and pathologic fractures. Ample space has been given to the description and imaging of the course of diseases under treatment by up-to-date therapies, as e.g. for ostitis deformans Paget's disease, or skeletal metastases. This second edition of the book incorporates the progress achieved over the last five years in skeletal diagnostics. The advances in this field have been resulting from basic research work, for instance in molecular biology, or from a variety of completed studies relating to clinical medicine, laboratory chemistry, histopathology and radiology of skeletal diseases, and from experience obtained with the diagnostic radiology methods and techniques, with the potentials and constraints of magnetic resonance imaging (MRI) today being more critically assessed than five years ago. MRI is a modality currently meeting with interest in the context of search for additional diagnostic information, new definition of complete pictures of diseases, or false or overinterpretation of diagnostic findings. (orig./MG). 431 figs [de

  18. Guidelines for system modeling: pre-accident human errors, rev.0

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Dae Il; Jung, W. D.; Lee, Y. H.; Hwang, M. J.; Yang, J. E

    2004-01-01

    The evaluation results of Human Reliability Analysis (HRA) of pre-accident human errors in the probabilistic safety assessment (PSA) for the Korea Standard Nuclear Power Plant (KSNP) using the ASME PRA standard show that more than 50% of 10 items to be improved are related to the identification and screening analysis for them. Thus, we developed a guideline for modeling pre-accident human errors for the system analyst to resolve some items to be improved for them. The developed guideline consists of modeling criteria for the pre-accident human errors (identification, qualitative screening, and common restoration errors) and detailed guidelines for pre-accident human errors relating to testing, maintenance, and calibration works of nuclear power plants (NPPs). The system analyst use the developed guideline and he or she applies it to the system which he or she takes care of. The HRA analyst review the application results of the system analyst. We applied the developed guideline to the auxiliary feed water system of the KSNP to show the usefulness of it. The application results of the developed guideline show that more than 50% of the items to be improved for pre-accident human errors of auxiliary feed water system are resolved. The guideline for modeling pre-accident human errors developed in this study can be used for other NPPs as well as the KSNP. It is expected that both use of the detailed procedure, to be developed in the future, for the quantification of pre-accident human errors and the guideline developed in this study will greatly enhance the PSA quality in the HRA of pre-accident human errors.

  19. Protection of the environment address book. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Winkler, B.

    1991-01-01

    This manual contains an extensive collection of non-commercial addresses relating to the protection of the environment: The collection includes the government-controlled, communal, scientific associations and groups, regional initiative groups, educational and advisory instances and foundations. When referring to scientific institutes, their main points of activity are given; referring to ecological educational instances, information on their programs is given. For the first time we are also given a list of environment protection authorities, divisions, coordination bureaus which have been set up in communities and big cities and the communal information and advisory programs. (orig.) [de

  20. Natural analogue synthesis report, TDR-NBS-GS-000027 REV00 ICN02

    International Nuclear Information System (INIS)

    Simmons, A.; Nieder-Westermann, G.; Stuckless, J.; Dobson, P.; Unger, A.J.A.; Kwicklis, E.; Lichtner, P.; Carey, B.; Wolde, G.; Murrel, M.; Kneafsey, T.J.; Meijer, A.; Faybishenko, B.

    2002-01-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the Yucca Mountain Site Description (CRWMS M and O 2000 [151945], Section 13) and new examples gleaned from the literature, along with results of quantitative studies conducted specifically for the Yucca Mountain Site Characterization Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement drift degradation, waste form degradation, waste package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated zone (SZ) transport, impact of radionuclide release on the biosphere, and potentially disruptive events. Results of these studies will be used to corroborate estimates of the magnitude and limitation of operative processes in order to build realism into conceptual and numerical process models used as a foundation for PA in the representative case of postclosure safety