WorldWideScience

Sample records for experimental drug research

  1. Lung MRI for experimental drug research

    International Nuclear Information System (INIS)

    Beckmann, Nicolau; Cannet, Catherine; Karmouty-Quintana, Harry; Tigani, Bruno; Zurbruegg, Stefan; Ble, Francois-Xavier; Cremillieux, Yannick; Trifilieff, Alexandre

    2007-01-01

    Current techniques to evaluate the efficacy of potential treatments for airways diseases in preclinical models are generally invasive and terminal. In the past few years, the flexibility of magnetic resonance imaging (MRI) to obtain anatomical and functional information of the lung has been explored with the scope of developing a non-invasive approach for the routine testing of drugs in models of airways diseases in small rodents. With MRI, the disease progression can be followed in the same animal. Thus, a significant reduction in the number of animals used for experimentation is achieved, as well as minimal interference with their well-being and physiological status. In addition, under certain circumstances the duration of the observation period after disease onset can be shortened since the technique is able to detect changes before these are reflected in parameters of inflammation determined using invasive procedures. The objective of this article is to briefly address MRI techniques that are being used in experimental lung research, with special emphasis on applications. Following an introduction on proton techniques and MRI of hyperpolarized gases, the attention is shifted to the MRI analysis of several aspects of lung disease models, including inflammation, ventilation, emphysema, fibrosis and sensory nerve activation. The next subject concerns the use of MRI in pharmacological studies within the context of experimental lung research. A final discussion points towards advantages and limitations of MRI in this area

  2. Drug research methodology. Volume 5, Experimentation in drugs and highway safety : the study of drug effects on skills related to driving

    Science.gov (United States)

    1980-06-01

    This report presents the findings of a workshop on experimental research in the area of drugs and highway safety. Complementing studies of drug use in different driving populations, experimentation here refers to studies performed under controlled co...

  3. Research on acute and chronic toxity of the experimental drug Аmprolinsyl

    Directory of Open Access Journals (Sweden)

    B. Gutyj

    2017-02-01

    Full Text Available The drug Amprolinsyl is a is a mixture of hydrochloric amprolium (12.5 g and milled fruits of the milk thistle (up to 100 g, designed to prevent and treat protozoonoses in birds, especially when mixed associative invasions occur. The fruits of the milk thistle contain the natural vitamins (A, C, E, B and the minerals (copper, iron, cobalt and other factors that significantly expand and enhance the pharmacological effect of the drug Amprolinsyl. We found that when the drug Amprolinsyl was administered intra gastrically to white rats at a dose of 5000 mg/kg and higher clinical signs of toxicity occurred after 4–5 hours. Damage to motor activity and tremors of individual muscles of these animals was observed. The rats died after 1–4 days. A direct relationship was found between the drug at a specific dosage and the death of rats. After intra gastric administration of the drug Amprolinsyl to white rats clinical signs of toxicity appeared after 5–6 hours at a dose of 4000 mg/kg body weight. These animals attempted to gather in groups and to hide in the bedding. The death of the mice occured in 1–3 days. Thus, LD50 drug of Amprolinsyl following intra gastric administration to white rats (5917 mg/kg and for white mice (5167 mg/kg. After studying the cumulative properties of Amprolinsyl, it was found that the total drug administered in avarage doses was 831 mg/kg, and the cumulative rate – 8.31. Long-term daily intragastric administration of Amprolinsyl over 24 days affected the functional state of the liver and kidneys. The magnitude of weight ratios of lungs, heart and spleen during the research period was the same as in the control group of rats. Significant changes were found only after analyzing the leukocyte profile. A reduction was observed in the number of neutrophils to 54.7% and an increase in the number of lymphocytes to 9.2%. Following prolonged daily administration of increasing doses Amprolinsyl causes a slight degradation of the

  4. Access to Experimental Cancer Drugs

    Science.gov (United States)

    An experimental drug has been tested in the lab and with animals and approved for testing in people by the FDA, but can’t yet be advertised, sold, or prescribed. Experimental drugs may be available through clinical trials or expanded access programs - learn more about these programs and how to talk to your doctor.

  5. Current knowledge from experimental works with radioprotective drugs from the viewpoint of latest scientific research

    International Nuclear Information System (INIS)

    Skalka, J.

    2008-01-01

    The protection of both human and animal population against a radiation impairment proves to be an impulse for continuous intensive searching for plants with radioprotective properties, identification of their radioprotective components and examination of their effects both in vivo an in vitro. I am presenting the results as well as knowledge of a latest scientific research in this field with testing the following plants: Vigna radiata, Mentha piperita, Citrus aurantium var. amara, Syzygium cumini, Tinospora cordifolia, Aegle marmelos, Phyllanthus amarus, Aloe vera, Angelica sinensis, Rosemarinus officinalis, Panax ginseng, Hippophae rhamnoides, Ocimum sanctum, Crataegus microphylla. (authors)

  6. Transonic Experimental Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Transonic Experimental Research Facility evaluates aerodynamics and fluid dynamics of projectiles, smart munitions systems, and sub-munitions dispensing systems;...

  7. Experimental Research in Marketing

    OpenAIRE

    Jose Mauro Hernandez; Kenny Basso; Marcelo Moll Brandão

    2014-01-01

    Considering the growing number of scientific studies published in the marketing field and the development of unique theories of the area (Hunt, 2010), using experimental designs seems increasingly appropriate to investigate marketing phenomena. This article aims to discuss the main elements in conducting experimental studies and also to stimulate researchers to adopt this research method. Several international journals (e.g., JCR, JCP, JMR, JR, JBR) have been publishing articles based on expe...

  8. Experimental Research in Marketing

    Directory of Open Access Journals (Sweden)

    Jose Mauro Hernandez

    2014-05-01

    Full Text Available Considering the growing number of scientific studies published in the marketing field and the development of unique theories of the area (Hunt, 2010, using experimental designs seems increasingly appropriate to investigate marketing phenomena. This article aims to discuss the main elements in conducting experimental studies and also to stimulate researchers to adopt this research method. Several international journals (e.g., JCR, JCP, JMR, JR, JBR have been publishing articles based on experiments that not only demonstrate a relationship between two events, but also elucidate how they occur by means of mediation and moderation analyses. This article intents to be a roadmap for novice researchers on how to conduct experiments and to offer new perspectives in experimental research for experienced researchers.  

  9. Experimental Design Research

    DEFF Research Database (Denmark)

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations...... of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology......, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current...

  10. Dendrimers in drug research

    DEFF Research Database (Denmark)

    Boas, Ulrik; Heegaard, Peter M. H.

    2004-01-01

    and in vivo cytotoxicity, as well as biopermeability, biostability and immunogenicity. The review deals with numerous applications of dendrimers as tools for efficient multivalent presentation of biological ligands in biospecific recognition, inhibition and targeting. Dendrimers may be used as drugs...... for antibacterial and antiviral treatment and have found use as antitumor agents. The review highlights the use of dendrimers as drug or gene delivery devices in e.g. anticancer therapy, and the design of different host-guest binding motifs directed towards medical applications is described. Other specific examples...

  11. Antiviral Drug Research Proposal Activity

    Directory of Open Access Journals (Sweden)

    Lisa Injaian

    2011-03-01

    Full Text Available The development of antiviral drugs provides an excellent example of how basic and clinical research must be used together in order to achieve the final goal of treating disease. A Research Oriented Learning Activity was designed to help students to better understand how basic and clinical research can be combined toward a common goal. Through this project students gained a better understanding of the process of scientific research and increased their information literacy in the field of virology. The students worked as teams to research the many aspects involved in the antiviral drug design process, with each student becoming an "expert" in one aspect of the project. The Antiviral Drug Research Proposal (ADRP culminated with students presenting their proposals to their peers and local virologists in a poster session. Assessment data showed increased student awareness and knowledge of the research process and the steps involved in the development of antiviral drugs as a result of this activity.

  12. Rationality and drug use: an experimental approach.

    Science.gov (United States)

    Blondel, Serge; Lohéac, Youenn; Rinaudo, Stéphane

    2007-05-01

    In rational addiction theory, higher discount rates encourage drug use. We test this hypothesis in the general framework of rationality and behaviour under risk. We do so using an experimental design with real monetary incentives. The decisions of 34 drug addicts are compared with those of a control group. The decisions of drug users (DU) are not any less consistent with standard theories of behaviour over time and under risk. Further, there is no difference in the estimated discount rate between drug users and the control group, but the former do appear to be more risk-seeking.

  13. Experimental Methods in Media Research

    NARCIS (Netherlands)

    C.W. Handke (Christian); C. Herzog (Christian)

    2017-01-01

    textabstractCausal effects are a prime concern in media policy research, and experimental research designs are widely regarded as the most effective way to identify and gauge causality. Nevertheless, explicit applications of experimental methods are rare in media policy research. This chapter

  14. Experimental plasma research project summaries

    International Nuclear Information System (INIS)

    1982-10-01

    The experimental plasma Research Branch has responsibility for developing a broad range of experimental data and new experimental techniques that are required for operating and interpreting present large-scale confinement experiments, and for designing future deuterium-tritium burining facilities. The Branch pursued these objectives by supporting research in DOE laboratories, other Federal laboratories, other Federal laboratories, universities, and private industry. Initiation and renewal of research projects are primarily through submission of unsolicited proposals by these institutions to DOE. Summaries of these projects are given

  15. Macrophage specific drug delivery in experimental leishmaniasis.

    Science.gov (United States)

    Basu, Mukul Kumar; Lala, Sanchaita

    2004-09-01

    Macrophage-specific delivery systems are the subject of much interest nowadays, because of the fact that macrophages act as host cells for many parasites and bacteria, which give rise to outbreak of so many deadly diseases(eg. leishmaniasis, tuberculosis etc.) in humans. To combat these deadly diseases initially macrophage specific liposomal delivery system were thought of and tested in vivo against experimental leishmaniasis in hamsters using a series of indigenous or synthetic antileishmanial compounds and the results were critically discussed. In vitro testing was also done against macrophages infected with Leishmania donovani, the causative agent for visceral leishmaniasis. The common problem of liposome therapy being their larger size, stability and storage, non-ionic surfactant vesicles, niosomes were prepared, for their different drug distribution and release characteristics compared to liposomes. When tested in vivo, the retention capacity of niosomes was found to be higher than that of liposomes due to the absence of lipid molecules and their smaller size. Thus the therapeutic efficacy of certain antileishmanial compounds was found to be better than that in the liposomal form. The niosomes, being cheaper, less toxic, biodegradable and non-immunogenic, were considered for sometime as suitable alternatives to liposomes as drug carriers. Besides the advent of other classical drugs carriers(e.g. neoglycoproteins), the biggest challenge came from polymeric delivery vehicles, specially the polymeric nanoparticles which were made of cost effective biodegradable polymers and different natural polymers. Because of very small size and highly stable nature, use of nanoparticles as effective drug carriers has been explored in experimental leishmaniasis using a series of antileishmanial compounds, both of indigenous and synthetic origin. The feasibility of application in vivo, when tested for biological as well as for other physicochemical parameters, the polymeric

  16. Experimental Plasma Research project summaries

    International Nuclear Information System (INIS)

    1980-09-01

    This report contains descriptions of the activities supported by the Experimental Plasma Research Branch of APP. The individual project summaries were prepared by the principal investigators and include objectives and milestones for each project. The projects are arranged in six research categories: Plasma Properties; Plasma Heating; Plasma Diagnostics; Atomic, Molecular and Nuclear Physics; Advanced Superconducting Materials; and the Fusion Plasma Research Facility (FPRF). Each category is introduced with a statement of objectives and recent progress and followed by descriptions of individual projects. An overall budget summary is provided at the beginning of the report

  17. Experimental plasma research project summaries

    International Nuclear Information System (INIS)

    1978-08-01

    This report contans descriptions of the activities supported by the Experimental Plasma Research Branch of APP. The individual project summaries were prepared by the principal investigators and include objectives and milestones for each project. The projects are arranged in six research categories: Plasma Properties; Plasma Heating; Plasma Measurements and Instrumentation; Atomic, Molecular and Nuclear Physics; Advanced Superconducting Materials; and the Fusion Plasma Research Facility (FPRF). Each category is introduced with a statement of objectives and recent progress and followed by descriptions of individual projects. An overall budget summary is provided at the beginning of the report

  18. Experimental Plasma Research project summaries

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    This report contains descriptions of the activities supported by the Experimental Plasma Research Branch of APP. The individual project summaries were prepared by the principal investigators and include objectives and milestones for each project. The projects are arranged in six research categories: Plasma Properties; Plasma Heating; Plasma Diagnostics; Atomic, Molecular and Nuclear Physics; Advanced Superconducting Materials; and the Fusion Plasma Research Facility (FPRF). Each category is introduced with a statement of objectives and recent progress and followed by descriptions of individual projects. An overall budget summary is provided at the beginning of the report.

  19. Experimental plasma research project summaries

    International Nuclear Information System (INIS)

    1992-06-01

    This is the latest in a series of Project Summary books going back to 1976 and is the first after a hiatus of several years. They are published to provide a short description of each project supported by the Experimental Plasma Research Branch of the Division of Applied Plasma Physics in the Office of Fusion Energy. The Experimental Plasma Research Branch seeks to provide a broad range of experimental data, physics understanding, and new experimental techniques that contribute to operation, interpretation, and improvement of high temperature plasma as a source of fusion energy. In pursuit of these objectives, the branch supports research at universities, DOE laboratories, other federal laboratories and industry. About 70 percent of the funds expended are spent at universities and a significant function of this program is the training of students in fusion physics. The branch supports small- and medium-scale experimental studies directly related to specific critical plasma issues of the magnetic fusion program. Plasma physics experiments are conducted on transport of particles and energy within plasma and innovative approaches for operating, controlling, and heating plasma are evaluated for application to the larger confinement devices of the magnetic fusion program. New diagnostic approaches to measuring the properties of high temperature plasmas are developed to the point where they can be applied with confidence on the large-scale confinement experiments. Atomic data necessary for impurity control, interpretation of diagnostic data, development of heating devices, and analysis of cooling by impurity ion radiation are obtained. The project summaries are grouped into these three categories of plasma physics, diagnostic development and atomic physics

  20. Experimental Research of Engine Foundations

    Directory of Open Access Journals (Sweden)

    Violeta-Elena Chiţan

    2004-01-01

    Full Text Available This paper tries a compact presentation of experimental research of engine-foundations. The dynamic phenomena are so complex, that the vibrations cannot be estimated in the design stage. The design engineer of an engine foundation must foresee through a dynamic analysis of the vibrations, those measures that lead to the avoidance or limiting of the bad effects caused by the vibrations.

  1. Center for Drug Evaluation and Research

    Data.gov (United States)

    Federal Laboratory Consortium — The Center for Drug Evaluation and Research(CDER) performs an essential public health task by making sure that safe and effective drugs are available to improve the...

  2. Safety Research and Experimental Coal Mines

    Data.gov (United States)

    Federal Laboratory Consortium — Safety Research and Experimental Coal MinesLocation: Pittsburgh SiteThe Safety Research Coal Mine and Experimental Mine complex is a multi-purpose underground mine...

  3. Experimental research control software system

    International Nuclear Information System (INIS)

    Cohn, I A; Kovalenko, A G; Vystavkin, A N

    2014-01-01

    A software system, intended for automation of a small scale research, has been developed. The software allows one to control equipment, acquire and process data by means of simple scripts. The main purpose of that development is to increase experiment automation easiness, thus significantly reducing experimental setup automation efforts. In particular, minimal programming skills are required and supervisors have no reviewing troubles. Interactions between scripts and equipment are managed automatically, thus allowing to run multiple scripts simultaneously. Unlike well-known data acquisition commercial software systems, the control is performed by an imperative scripting language. This approach eases complex control and data acquisition algorithms implementation. A modular interface library performs interaction with external interfaces. While most widely used interfaces are already implemented, a simple framework is developed for fast implementations of new software and hardware interfaces. While the software is in continuous development with new features being implemented, it is already used in our laboratory for automation of a helium-3 cryostat control and data acquisition. The software is open source and distributed under Gnu Public License.

  4. Experimental research control software system

    Science.gov (United States)

    Cohn, I. A.; Kovalenko, A. G.; Vystavkin, A. N.

    2014-05-01

    A software system, intended for automation of a small scale research, has been developed. The software allows one to control equipment, acquire and process data by means of simple scripts. The main purpose of that development is to increase experiment automation easiness, thus significantly reducing experimental setup automation efforts. In particular, minimal programming skills are required and supervisors have no reviewing troubles. Interactions between scripts and equipment are managed automatically, thus allowing to run multiple scripts simultaneously. Unlike well-known data acquisition commercial software systems, the control is performed by an imperative scripting language. This approach eases complex control and data acquisition algorithms implementation. A modular interface library performs interaction with external interfaces. While most widely used interfaces are already implemented, a simple framework is developed for fast implementations of new software and hardware interfaces. While the software is in continuous development with new features being implemented, it is already used in our laboratory for automation of a helium-3 cryostat control and data acquisition. The software is open source and distributed under Gnu Public License.

  5. Experimental research on air propellers

    Science.gov (United States)

    Durand, William F

    1918-01-01

    The purposes of the experimental investigation on the performance of air propellers described in this report are as follows: (1) the development of a series of design factors and coefficients drawn from model forms distributed with some regularity over the field of air-propeller design and intended to furnish a basis of check with similar work done in other aerodynamic laboratories, and as a point of departure for the further study of special or individual types and forms; (2) the establishment of a series of experimental values derived from models and intended for later use as a basis for comparison with similar results drawn from certain selected full-sized forms and tested in free flight.

  6. Research in experimental nuclear physics

    International Nuclear Information System (INIS)

    Moore, C.F.

    1989-09-01

    Our program concentrates on pion physics experimental results obtained using the Energetic Pion Channel and Spectrometer (EPICS), Pion and Particle Physics channel (P 3 ), and the Low Energy Pion physics channel (LEP). These facilities are unique in the world in their intensity and resolution. Two classes of experiments can be done best with this equipment: scattering (elastic and inelastic) and double charge exchange (DCX). Several coincidence experiments are in progress and are discussed in this paper

  7. Microfluidic cell culture systems for drug research.

    Science.gov (United States)

    Wu, Min-Hsien; Huang, Song-Bin; Lee, Gwo-Bin

    2010-04-21

    In pharmaceutical research, an adequate cell-based assay scheme to efficiently screen and to validate potential drug candidates in the initial stage of drug discovery is crucial. In order to better predict the clinical response to drug compounds, a cell culture model that is faithful to in vivo behavior is required. With the recent advances in microfluidic technology, the utilization of a microfluidic-based cell culture has several advantages, making it a promising alternative to the conventional cell culture methods. This review starts with a comprehensive discussion on the general process for drug discovery and development, the role of cell culture in drug research, and the characteristics of the cell culture formats commonly used in current microfluidic-based, cell-culture practices. Due to the significant differences in several physical phenomena between microscale and macroscale devices, microfluidic technology provides unique functionality, which is not previously possible by using traditional techniques. In a subsequent section, the niches for using microfluidic-based cell culture systems for drug research are discussed. Moreover, some critical issues such as cell immobilization, medium pumping or gradient generation in microfluidic-based, cell-culture systems are also reviewed. Finally, some practical applications of microfluidic-based, cell-culture systems in drug research particularly those pertaining to drug toxicity testing and those with a high-throughput capability are highlighted.

  8. Drug utilization research and risk management

    NARCIS (Netherlands)

    Mazzaglia, Giampiero; Mol, Peter G. M.; Elseviers, Monique; Wettermark, Björn; Almarsdóttir, Anna Birna; Andersen, Morten; Benko, Ria; Bennie, Marion; Eriksson, Irene; Godman, Brian; Krska, Janet; Poluzzi, Elisabetta; Taxis, Katja; Vlahovic-Palcevski, Vera; Stichele, Robert Vander

    2016-01-01

    Good risk management requires continuous evaluation and improvement of planned activities. The evaluation impact of risk management activities requires robust study designs and carefully selected outcome measures. Key learnings and caveats from drug utilization research should be applied to the

  9. Benzodiazepines, opioids and driving: an overview of the experimental research.

    Science.gov (United States)

    Leung, Stefanie Y

    2011-05-01

    Road crashes contribute significantly to the total burden of injury in Australia, with the risk of injury being associated with the presence of drugs and/or alcohol in the driver's blood. Increasingly, some of the most commonly detected drugs include prescription medicines, the most notable of these being benzodiazepines and opioids. However, there is a paucity of experimental research into the effects of prescribed psychoactive drugs on driving behaviours. This paper provides an overview of experimental studies investigating the effects of prescribed doses of benzodiazepines and opioids on driving ability, and points to future directions for research. There is growing epidemiological evidence linking the therapeutic use of benzodiazepines and opioids to an increased crash risk. However, the current experimental literature remains unclear. Limitations to study methodologies have resulted in inconsistent findings. Limited experimental evidence exists to inform policy and guidelines regarding fitness-to-drive for patients taking prescribed benzodiazepines and opioids. Further experimental research is required to elucidate the effects of these medications on driving, under varying conditions and in different medical contexts. This will ensure that doctors prescribing benzodiazepines and opioids are well informed, and can appropriately advise patients of the risks associated with driving whilst taking these medications. © 2011 Australasian Professional Society on Alcohol and other Drugs.

  10. Targeting molecular networks for drug research

    Directory of Open Access Journals (Sweden)

    José Pedro Pinto

    2014-06-01

    Full Text Available The study of molecular networks has recently moved into the limelight of biomedical research. While it has certainly provided us with plenty of new insights into cellular mechanisms, the challenge now is how to modify or even restructure these networks. This is especially true for human diseases, which can be regarded as manifestations of distorted states of molecular networks. Of the possible interventions for altering networks, the use of drugs is presently the most feasible. In this mini-review, we present and discuss some exemplary approaches of how analysis of molecular interaction networks can contribute to pharmacology (e.g., by identifying new drug targets or prediction of drug side effects, as well as listing pointers to relevant resources and software to guide future research. We also outline recent progress in the use of drugs for in vitro reprogramming of cells, which constitutes an example par excellence for altering molecular interaction networks with drugs.

  11. Research and Experimentation in Prisons.

    Science.gov (United States)

    Swan, L. Alex

    1979-01-01

    The author argues that the prison system is inherently coercive, and that social and behavioral scientists have been used by state agents to facilitate control of prisoners. He urges that the major objective of research in prisons be to promote the principle of human liberation. (Author/RLV)

  12. Qualitative Methods in Drug Utilization Research

    DEFF Research Database (Denmark)

    Almarsdóttir, Anna Birna; Bastholm Rahmner, Pia

    2016-01-01

    Qualitative research methods derive from the social sciences. Their use in drug utilization research is increasingly widespread, especially in understanding patient and prescriber perspectives. The main focus in qualitative research is exploration of a given phenomenon in order to get a wider...... understanding of why and how it appears. Qualitative research methods build on various theoretical underpinnings/schools of thought. The same validity and quality criteria cannot be used for both qualitative and quantitative methods....

  13. Experimental High Energy Physics Research

    Energy Technology Data Exchange (ETDEWEB)

    Hohlmann, Marcus [Florida Inst. of Technology, Melbourne, FL (United States). Dept. of Physics and Space Sciences

    2016-01-13

    This final report summarizes activities of the Florida Tech High Energy Physics group supported by DOE under grant #DE-SC0008024 during the period June 2012 – March 2015. We focused on one of the main HEP research thrusts at the Energy Frontier by participating in the CMS experiment. We were exploiting the tremendous physics opportunities at the Large Hadron Collider (LHC) and prepared for physics at its planned extension, the High-Luminosity LHC. The effort comprised a physics component with analysis of data from the first LHC run and contributions to the CMS Phase-2 upgrades in the muon endcap system (EMU) for the High-Luminosity LHC. The emphasis of our hardware work was the development of large-area Gas Electron Multipliers (GEMs) for the CMS forward muon upgrade. We built a production and testing site for such detectors at Florida Tech to complement future chamber production at CERN. The first full-scale CMS GE1/1 chamber prototype ever built outside of CERN was constructed at Florida Tech in summer 2013. We conducted two beam tests with GEM prototype chambers at CERN in 2012 and at FNAL in 2013 and reported the results at conferences and in publications. Principal Investigator Hohlmann served as chair of the collaboration board of the CMS GEM collaboration and as co-coordinator of the GEM detector working group. He edited and authored sections of the detector chapter of the Technical Design Report (TDR) for the GEM muon upgrade, which was approved by the LHCC and the CERN Research Board in 2015. During the course of the TDR approval process, the GEM project was also established as an official subsystem of the muon system by the CMS muon institution board. On the physics side, graduate student Kalakhety performed a Z' search in the dimuon channel with the 2011 and 2012 CMS datasets that utilized 20.6 fb⁻¹ of p-p collisions at √s = 8 TeV. For the dimuon channel alone, the 95% CL lower limits obtained on the mass of a Z' resonance are 2770 Ge

  14. Preclinical experimental models of drug metabolism and disposition in drug discovery and development

    Directory of Open Access Journals (Sweden)

    Donglu Zhang

    2012-12-01

    Full Text Available Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different stages of drug discovery and development for determination of efficacy and safety. The proper selection and applications of correct models, as well as appropriate data interpretation, are critically important in decision making and successful advancement of drug candidates. In this review, we discuss strategies in the applications of both in vitro and in vivo experimental models of drug metabolism and disposition.

  15. Computational and experimental model of transdermal iontophorethic drug delivery system.

    Science.gov (United States)

    Filipovic, Nenad; Saveljic, Igor; Rac, Vladislav; Graells, Beatriz Olalde; Bijelic, Goran

    2017-11-30

    The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst-Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Quasi experimental designs in pharmacist intervention research.

    Science.gov (United States)

    Krass, Ines

    2016-06-01

    Background In the field of pharmacist intervention research it is often difficult to conform to the rigorous requirements of the "true experimental" models, especially the requirement of randomization. When randomization is not feasible, a practice based researcher can choose from a range of "quasi-experimental designs" i.e., non-randomised and at time non controlled. Objective The aim of this article was to provide an overview of quasi-experimental designs, discuss their strengths and weaknesses and to investigate their application in pharmacist intervention research over the previous decade. Results In the literature quasi experimental studies may be classified into five broad categories: quasi-experimental design without control groups; quasi-experimental design that use control groups with no pre-test; quasi-experimental design that use control groups and pre-tests; interrupted time series and stepped wedge designs. Quasi-experimental study design has consistently featured in the evolution of pharmacist intervention research. The most commonly applied of all quasi experimental designs in the practice based research literature are the one group pre-post-test design and the non-equivalent control group design i.e., (untreated control group with dependent pre-tests and post-tests) and have been used to test the impact of pharmacist interventions in general medications management as well as in specific disease states. Conclusion Quasi experimental studies have a role to play as proof of concept, in the pilot phases of interventions when testing different intervention components, especially in complex interventions. They serve to develop an understanding of possible intervention effects: while in isolation they yield weak evidence of clinical efficacy, taken collectively, they help build a body of evidence in support of the value of pharmacist interventions across different practice settings and countries. However, when a traditional RCT is not feasible for

  17. Experimental atomic and molecular physics research

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    The Atomic Physics research in the Physics Division consists of five ongoing experimental programs: dissociation and other interactions of energetic molecular ions in solid and gaseous targets; beam-foil research and collision dynamics of heavy ions; photoionization-photoelectron research; spectroscopy of free atoms and molecules, high precision laser-rf double-resonance spectroscopy with atomic and molecular beams; and Moessbauer effect research

  18. 75 FR 45130 - Guidance for Industry and Researchers on the Radioactive Drug Research Committee: Human Research...

    Science.gov (United States)

    2010-08-02

    ... and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, rm. 2201, Silver... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2009-D-0125] Guidance for Industry and Researchers on the Radioactive Drug Research Committee: Human Research Without an...

  19. Drugs and Minorities. Research Issues 21.

    Science.gov (United States)

    Austin, Gregory A., Ed.; And Others

    This volume contains summaries of the latest research focusing on the issue of the extent of drug use and abuse among racial and ethnic minorities and the factors influencing it. Taken into consideration are age and sex differences among users, narcotics addiction, socioeconomic influences, cultural factors, racial factors, demographic factors,…

  20. [Animal experimentation, computer simulation and surgical research].

    Science.gov (United States)

    Carpentier, Alain

    2009-11-01

    We live in a digital world In medicine, computers are providing new tools for data collection, imaging, and treatment. During research and development of complex technologies and devices such as artificial hearts, computer simulation can provide more reliable information than experimentation on large animals. In these specific settings, animal experimentation should serve more to validate computer models of complex devices than to demonstrate their reliability.

  1. Experimental design research approaches, perspectives, applications

    CERN Document Server

    Stanković, Tino; Štorga, Mario

    2016-01-01

    This book presents a new, multidisciplinary perspective on and paradigm for integrative experimental design research. It addresses various perspectives on methods, analysis and overall research approach, and how they can be synthesized to advance understanding of design. It explores the foundations of experimental approaches and their utility in this domain, and brings together analytical approaches to promote an integrated understanding. The book also investigates where these approaches lead to and how they link design research more fully with other disciplines (e.g. psychology, cognition, sociology, computer science, management). Above all, the book emphasizes the integrative nature of design research in terms of the methods, theories, and units of study—from the individual to the organizational level. Although this approach offers many advantages, it has inherently led to a situation in current research practice where methods are diverging and integration between individual, team and organizational under...

  2. An Introduction to Experimental Design Research

    DEFF Research Database (Denmark)

    Cash, Philip; Stanković, Tino; Štorga, Mario

    2016-01-01

    Design research brings together influences from the whole gamut of social, psychological, and more technical sciences to create a tradition of empirical study stretching back over 50 years (Horvath 2004; Cross 2007). A growing part of this empirical tradition is experimental, which has gained in ...

  3. Data Analysis in Experimental Biomedical Research

    DEFF Research Database (Denmark)

    Markovich, Dmitriy

    This thesis covers two non-related topics in experimental biomedical research: data analysis in thrombin generation experiments (collaboration with Novo Nordisk A/S), and analysis of images and physiological signals in the context of neurovascular signalling and blood flow regulation in the brain...... to critically assess and compare obtained results. We reverse engineered the data analysis performed by CAT, a de facto standard assay in the field. This revealed a number of possibilities to improve its methods of data analysis. We found that experimental calibration data is described well with textbook...

  4. Multi-target drugs: the trend of drug research and development.

    Science.gov (United States)

    Lu, Jin-Jian; Pan, Wei; Hu, Yuan-Jia; Wang, Yi-Tao

    2012-01-01

    Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future.

  5. Experimental methods of shock wave research

    CERN Document Server

    Seiler, Friedrich

    2016-01-01

    This comprehensive and carefully edited volume presents a variety of experimental methods used in Shock Waves research. In 14 self contained chapters this 9th volume of the “Shock Wave Science and Technology Reference Library” presents the experimental methods used in Shock Tubes, Shock Tunnels and Expansion Tubes facilities. Also described is their set-up and operation. The uses of an arc heated wind tunnel and a gun tunnel are also contained in this volume. Whenever possible, in addition to the technical description some typical scientific results obtained using such facilities are described. Additionally, this authoritative book includes techniques for measuring physical properties of blast waves and laser generated shock waves. Information about active shock wave laboratories at different locations around the world that are not described in the chapters herein is given in the Appendix, making this book useful for every researcher involved in shock/blast wave phenomena.

  6. Experimental nuclear physics research in Hungary

    International Nuclear Information System (INIS)

    Koltay, Ede.

    1984-01-01

    The status and recent results of experimental nuclear physics in Hungary is reviewed. The basic nuclear sciences, instrumental background and international cooperation are discussed. Personal problems and the effects of the international scientific deconjuncture are described. The applied nuclear and interdisciplinary researches play an important role in Hungarian nuclear physics. Some problems of cooperation of Hungarian nuclear and other research institutes applying or producing nuclear analytical technology are reviewed. The new instrument, the Debrecen cyclotron under construction gives new possibilities to basic and applied researches. A new field of Hungarian nuclear physics is the fusion and plasma research using tokamak equipment, the main topics of which are plasma diagnostics and fusion control systems. Some practical applications of Hungarian nuclear physical results, e.g. establishment of new analytical techniques like PIXE, RBS, PIGE, ESCA, etc. are summarized. (D.Gy.)

  7. Instrumental and ethical aspects of experimental research with animal models

    Directory of Open Access Journals (Sweden)

    Mirian Watanabe

    2014-02-01

    Full Text Available Experimental animal models offer possibilities of physiology knowledge, pathogenesis of disease and action of drugs that are directly related to quality nursing care. This integrative review describes the current state of the instrumental and ethical aspects of experimental research with animal models, including the main recommendations of ethics committees that focus on animal welfare and raises questions about the impact of their findings in nursing care. Data show that, in Brazil, the progress in ethics for the use of animals for scientific purposes was consolidated with Law No. 11.794/2008 establishing ethical procedures, attending health, genetic and experimental parameters. The application of ethics in handling of animals for scientific and educational purposes and obtaining consistent and quality data brings unquestionable contributions to the nurse, as they offer subsidies to relate pathophysiological mechanisms and the clinical aspect on the patient.

  8. Prolonged drug-induced hypothermia in experimental stroke

    DEFF Research Database (Denmark)

    Johansen, Flemming Fryd; Jørgensen, Henrik Stig; Reith, Jakob

    2007-01-01

    In experimental and human stroke, hypothermia is strongly related to a favorable outcome. Previous attempts to manipulate the core temperature in focal cerebral ischemia have been based on mechanical cooling. The purpose of the study is to establish a model for long-term drug-induced hypothermia...... in focal ischemia by pharmacological alteration of the central thermoregulatory set-point. We tested the hypothesis that the dopaminergic agonist Talipexole, which induces hypothermia, reduces infarct size. Body temperature was monitored by a radio-pill-implant. Rats had reversible occlusion of the middle...... that the core body temperature was reduced by 1.7 degrees C for 24 hours after MCAO in rats treated with Talipexole. This treatment induced a significant reduction of infarct volume at 7 days after focal ischemia by 47%. We suggest that the reduction in infarct volume is related to drug-induced hypothermia...

  9. Characterization of experimental dental research using animals

    Directory of Open Access Journals (Sweden)

    Ana Flávia Granville-Garcia

    2009-01-01

    Full Text Available Objective: To determine the profile of experimental dental research using animals. Methods: The research comprised all the 4141 abstracts existent in the books of annals from the 22nd and 23rd Annual meetings of the Brazilian Society of Dentistry Research and the sample was composed of 377 studies (9.1%. The variables analyzed were: area of knowledge, type of institution, State of the country, type of animal and body part used, occurrence of animal sacrifice, mention of the Research Ethics Committee, receipt of funding and type of financing agency. Results: The largest number of studies concentrated on the areas of Buccomaxillofacial Surgery (27.3% and Basic Sciences (21.2%. The Public Universities were responsible for 74% of the researches, and the State Institutions were outstanding (82.4%. The State of São Paulo was responsible for 74.1% of the studies. Rats (67.1% and rabbits (11.1% were the most frequently used animals, and 68.2% of the animals were sacrificed. The oral cavity was used in 50.1% of the researches and the mandible in 59%. Only 1.9% of the studies mentioned the Research Ethics Committee and 26.3% reported that they received funding. Conclusion: In Dentistry, studies involving animals are predominant in the areas of buccomaxillofacial surgery and basic sciences, with rats andrabbits being most frequently used. A significant number of guinea pigs are sacrificed during or at the end of the experiments.

  10. [Experimental therapy of cardiac remodeling with quercetin-containing drugs].

    Science.gov (United States)

    Kuzmenko, M A; Pavlyuchenko, V B; Tumanovskaya, L V; Dosenko, V E; Moybenko, A A

    2013-01-01

    It was shown that continuous beta-adrenergic hyperstimulation resulted in cardiac function disturbances and fibrosis of cardiac tissue. Treatment with quercetin-containing drugs, particularly, water-soluble corvitin and tableted quertin exerted favourable effect on cardiac hemodynamics, normalized systolic and diastolic function in cardiac remodeling, induced by sustained beta-adrenergic stimulation. It was estimated that conducted experimental therapy limited cardiac fibrosis area almost three-fold, that could be associated with first and foremost improved cardiac distensibility, characteristics of diastolic and also pump function in cardiac remodeling.

  11. Optimising experimental research in respiratory diseases: an ERS statement.

    Science.gov (United States)

    Bonniaud, Philippe; Fabre, Aurélie; Frossard, Nelly; Guignabert, Christophe; Inman, Mark; Kuebler, Wolfgang M; Maes, Tania; Shi, Wei; Stampfli, Martin; Uhlig, Stefan; White, Eric; Witzenrath, Martin; Bellaye, Pierre-Simon; Crestani, Bruno; Eickelberg, Oliver; Fehrenbach, Heinz; Guenther, Andreas; Jenkins, Gisli; Joos, Guy; Magnan, Antoine; Maitre, Bernard; Maus, Ulrich A; Reinhold, Petra; Vernooy, Juanita H J; Richeldi, Luca; Kolb, Martin

    2018-05-01

    Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective.The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numbers of animals employed, thereby enhancing the ethical standards and translational capacity of experimental research.The task force statement addresses general issues of experimental research (ethics, species, sex, age, ex vivo and in vitro models, gene editing). The statement also includes research recommendations on modelling asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, lung infections, acute lung injury and pulmonary hypertension.The task force stressed the importance of using multiple models to strengthen validity of results, the need to increase the availability of human tissues and the importance of standard operating procedures and data quality. Copyright ©ERS 2018.

  12. Diterpenes: Advances in Neurobiological Drug Research.

    Science.gov (United States)

    Islam, Md Torequl; da Silva, Claucenira Bandeira; de Alencar, Marcus Vinícius Oliveira Barros; Paz, Márcia Fernanda Correia Jardim; Almeida, Fernanda Regina de Castro; Melo-Cavalcante, Ana Amélia de Carvalho

    2016-06-01

    A significant number of studies have been performed with diterpene effect on the brain. Our study aims to make a systematic revision on them. The initial purpose of this review was to screen diterpenes with neurological activity, in particular those that have already been studied and published in different journals (databases until August 2015). The second purpose was to make an action-wise discussion as results viewed on them by taking into drug discovery and development account. Diterpenes considered in this review were selected on the basis of updated information on them and having sufficient information on their screenings. We identified several examples of diterpenes having an interest in further study. We have included the possible sources of them as observed in evidence, their known molecular neurobiological mechanisms, and the active constituents responsible for such activities with the doses and test systems. Results suggest diterpenes to have neurobiological activities like neuro-protection, anti-epileptic, anxiolytic, anti-Alzheimer's disease, anti-Parkinson's disease, anti-cerebral ischemia, anti-neuropathic pain, anti-neuro-inflammatory, and many more. In conclusion, diterpenes may be the prominent candidates in neurobiological drug research. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Experimental research of flow servo-valve

    Directory of Open Access Journals (Sweden)

    Takosoglu Jakub

    2017-01-01

    Full Text Available Positional control of pneumatic drives is particularly important in pneumatic systems. Some methods of positioning pneumatic cylinders for changeover and tracking control are known. Choking method is the most development-oriented and has the greatest potential. An optimal and effective method, particularly when applied to pneumatic drives, has been searched for a long time. Sophisticated control systems with algorithms utilizing artificial intelligence methods are designed therefor. In order to design the control algorithm, knowledge about real parameters of servo-valves used in control systems of electro-pneumatic servo-drives is required. The paper presents the experimental research of flow servo-valve.

  14. Experimental research of flow servo-valve

    Science.gov (United States)

    Takosoglu, Jakub

    Positional control of pneumatic drives is particularly important in pneumatic systems. Some methods of positioning pneumatic cylinders for changeover and tracking control are known. Choking method is the most development-oriented and has the greatest potential. An optimal and effective method, particularly when applied to pneumatic drives, has been searched for a long time. Sophisticated control systems with algorithms utilizing artificial intelligence methods are designed therefor. In order to design the control algorithm, knowledge about real parameters of servo-valves used in control systems of electro-pneumatic servo-drives is required. The paper presents the experimental research of flow servo-valve.

  15. On Coba and Cocok: youth-led drug-experimentation in Eastern Indonesia.

    Science.gov (United States)

    Hardon, Anita; Idrus, Nurul Ilmi

    2014-01-01

    The everyday lives of contemporary youths are awash with drugs to boost pleasure, moods, sexual performance, vitality, appearance and health. This paper examines pervasive practices of chemical 'self-maximization' from the perspectives of youths themselves. The research for this paper was conducted among male, female and transgender (male to female, so-called waria) sex workers in Makassar, Indonesia. It presents the authors' ethnographic findings on how these youths experiment with drugs to achieve their desired mental and bodily states: with the painkiller Somadril to feel happy, confident and less reluctant to engage in sex with clients, and contraceptive pills and injectable hormones to feminize their male bodies and to attract customers. Youths are extremely creative in adjusting dosages and mixing substances, with knowledge of the (mostly positive) 'lived effects' of drugs spreading through collective experimentation and word of mouth. The paper outlines how these experimental practices differ from those that have become the gold standard in biomedicine.

  16. An experimental platform for systemic drug delivery to the retina.

    LENUS (Irish Health Repository)

    Campbell, Matthew

    2009-10-20

    Degenerative retinopathies, including age-related macular degeneration, diabetic retinopathy, and hereditary retinal disorders--major causes of world blindness--are potentially treatable by using low-molecular weight neuroprotective, antiapoptotic, or antineovascular drugs. These agents are, however, not in current systemic use owing to, among other factors, their inability to passively diffuse across the microvasculature of the retina because of the presence of the inner blood-retina barrier (iBRB). Moreover, preclinical assessment of the efficacies of new formulations in the treatment of such conditions is similarly compromised. We describe here an experimental process for RNAi-mediated, size-selective, transient, and reversible modulation of the iBRB in mice to molecules up to 800 Da by suppression of transcripts encoding claudin-5, a protein component of the tight junctions of the inner retinal vasculature. MRI produced no evidence indicative of brain or retinal edema, and the process resulted in minimal disturbance of global transcriptional patterns analyzed in neuronal tissue. We show that visual function can be improved in IMPDH1(-\\/-) mice, a model of autosomal recessive retinitis pigmentosa, and that the rate of photoreceptor cell death can be reduced in a model of light-induced retinal degeneration by systemic drug delivery after reversible barrier opening. These findings provide a platform for high-throughput drug screening in models of retinal degeneration, and they ultimately could result in the development of a novel "humanized" approach to therapy for conditions with little or no current forms of treatment.

  17. [Animal experimentation, animal welfare and scientific research].

    Science.gov (United States)

    Tal, H

    2013-10-01

    Hundreds of thousands of laboratory animals are being used every year for scientific experiments held in Israel, mostly mice, rats, rabbits, guinea pigs, and a few sheep, cattle, pigs, cats, dogs, and even a few dozen monkeys. In addition to the animals sacrificed to promote scientific research, millions of animals slain every year for other purposes such as meat and fine leather fashion industries. While opening a front against all is an impossible and perhaps an unjustified task, the state of Israel enacted the Animal Welfare (Animal Experimentation) Law (1994). The law aims to regulate scientific animal experiments and to find the appropriate balance between the need to continue to perform animal experiments for the advancement of research and medicine, and at the same time to avoid unnecessary trials and minimize animal suffering. Among other issues the law deals with the phylogenetic scale according to which experimental animals should be selected, experiments for teaching and practicing, and experiments for the cosmetic industry. This article discusses bioethics considerations in animal experiments as well as the criticism on the scientific validity of such experiments. It further deals with the vitality of animal studies and the moral and legal obligation to prevent suffering from laboratory animals.

  18. Drug induced acute kidney injury: an experimental animal study

    International Nuclear Information System (INIS)

    Khan, M.W.A.; Khan, B.T.; Qazi, R.A.; Ashraf, M.; Waqar, M.

    2017-01-01

    Objective: To assess the extent of drug induced nephrotoxicity in laboratory animals for determining the role and extent of iatrogenic kidney damage in patients exposed to nephrotoxic drugs in various clinical setups. Study Design: Randomized control trail. Place and Duration of study: Pharmacology department and animal house of Army Medical College from Jan 2011 to Aug 2011. Material and Methods: Thirty six mixed breed rabbits were used in this study. Animals were randomly divided into six groups consisting of six rabbits in each. Groups were named A, B, C, D, E and F. Group A was control group. Group B was given 0.9% normal saline. Group C rabbits were given acute nephrotoxic single dose of amphotericin B deoxycholate. Group D received 0.9% normal saline 10ml/kg followed by amphotericin B infusion. Group E was injected acute nephrotoxic regimen of cyclosporine and amphotericin B infusion. Group F received saline loading along with acute nephrotoxic regimen of cyclosporine and amphotericin B infusion. Results: Biochemical and histopathological analysis showed significant kidney injury in rabbits exposed to acute nephrotoxic doses of amphotericin B and cyclosporine. Toxicity was additive when the two drugs were administered simultaneously. Group of rabbits with saline loading had significantly lesser kidney damage. Conclusion: Iatrogenic acute kidney damage is a major cause of morbidity in experimental animals exposed to such nephrotoxic drugs like amphotericin B and cyclosporine, used either alone or in combination. Clinical studies are recommended to assess the extent of iatrogenic renal damage in patients and its economic burden. Efficient and cost effective protective measure may be adopted in clinical setups against such adverse effects. (author)

  19. Adaptive Programming Improves Outcomes in Drug Court: An Experimental Trial.

    Science.gov (United States)

    Marlowe, Douglas B; Festinger, David S; Dugosh, Karen L; Benasutti, Kathleen M; Fox, Gloria; Croft, Jason R

    2012-04-01

    Prior studies in Drug Courts reported improved outcomes when participants were matched to schedules of judicial status hearings based on their criminological risk level. The current experiment determined whether incremental efficacy could be gained by periodically adjusting the schedule of status hearings and clinical case-management sessions in response to participants' ensuing performance in the program. The adjustments were made pursuant to a priori criteria specified in an adaptive algorithm. Results confirmed that participants in the full adaptive condition (n = 62) were more than twice as likely as those assigned to baseline-matching only (n = 63) to be drug-abstinent during the first 18 weeks of the program; however, graduation rates and the average time to case resolution were not significantly different. The positive effects of the adaptive program appear to have stemmed from holding noncompliant participants more accountable for meeting their attendance obligations in the program. Directions for future research and practice implications are discussed.

  20. 78 FR 20664 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Science.gov (United States)

    2013-04-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001] Society of Clinical Research Associates-Food and Drug Administration: Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice AGENCY: Food and Drug...

  1. Plant natural products research in tuberculosis drug discovery and ...

    African Journals Online (AJOL)

    Plant natural products research in tuberculosis drug discovery and development: A situation report ... African Journal of Biotechnology ... tuberculosis (XDR-TB), call for the development of new anti-tuberculosis drugs to combat this disease.

  2. Experimental research on air propellers V

    Science.gov (United States)

    Durand, W F; Lesley, E P

    1923-01-01

    In previous reports on experimental research on air propellers, by W. F. Durand and E. P. Lesley, as contained in the National Advisory Committee for Aeronautics reports nos. 14, 30, and 64, the investigations were made progressively and each without reference to results given in preceding reports and covering only information relating to forms perhaps adjacent in geometrical form and proportion. This report is a review of the entire series of results of the preceding reports with a view of examining through graphical and other appropriate means the nature of the history of the characteristics of operation as related to the systematic variations in characteristics of forms, etc., through the series of such characteristics.

  3. Computer network for experimental research using ISDN

    International Nuclear Information System (INIS)

    Ida, Katsumi; Nakanishi, Hideya

    1997-01-01

    This report describes the development of a computer network that uses the Integrated Service Digital Network (ISDN) for real-time analysis of experimental plasma physics and nuclear fusion research. Communication speed, 64/128kbps (INS64) or 1.5Mbps (INS1500) per connection, is independent of how busy the network is. When INS-1500 is used, the communication speed, which is proportional to the public telephone connection fee, can be dynamically varied from 64kbps to 1472kbps (depending on how much data are being transferred using the Bandwidth-on-Demand (BOD) function in the ISDN Router. On-demand dial-up and time-out disconnection reduce the public telephone connection fee by 10%-97%. (author)

  4. Experimental facilities for Generation IV reactors research

    International Nuclear Information System (INIS)

    Krecanova, E.; Di Gabriele, F.; Berka, J.; Zychova, M.; Macak, J.; Vojacek, A.

    2013-06-01

    Centrum Vyzkumu Rez (CVR) is research and development Company situated in Czech Republic and member of the UJV group. One of its major fields is material research for Generation IV reactor concepts, especially supercritical water-cooled reactor (SCWR), very high temperature/gas-cooled fast reactor (VHTR/GFR) and lead-cooled fast reactor (LFR). The CVR is equipped by and is building unique experimental facilities which simulate the environment in the active zones of these reactor concepts and enable to pre-qualify and to select proper constructional materials for the most stressed components of the facility (cladding, vessel, piping). New infrastructure is founded within the Sustainable Energy project focused on implementation the Generation IV and fusion experimental facilities. The research of SCWR concept is divided to research and development of the constructional materials ensured by SuperCritical Water Loop (SCWL) and fuel components research on Fuel Qualification Test loop (SCWL-FQT). SCWL provides environment of the primary circuits of European SCWR, pressure 25 MPa, temperature 600 deg. C and its major purpose is to simulate behavior of the primary medium and candidate constructional materials. On-line monitoring system is included to collect the operational data relevant to experiment and its evaluation (pH, conductivity, chemical species concentration). SCWL-FQT is facility focused on the behavior of cladding material and fuel at the conditions of so-called preheater, the first pass of the medium through the fuel (in case of European SCWR concept). The conditions are 450 deg. C and 25 MPa. SCWL-FQT is unique facility enabling research of the shortened fuel rods. VHTR/GFR research covers material testing and also cleaning methods of the medium in primary circuit. The High Temperature Helium Loop (HTHL) enables exposure of materials and simulates the VHTR/GFR core environment to analyze the behavior of medium, especially in presence of organic compounds and

  5. Nuclear Criticality Experimental Research Center (NCERC) Overview

    Energy Technology Data Exchange (ETDEWEB)

    Goda, Joetta Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Grove, Travis Justin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes, David Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Myers, William L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sanchez, Rene Gerardo [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-03

    The mission of the National Criticality Experiments Research Center (NCERC) at the Device Assembly Facility (DAF) is to conduct experiments and training with critical assemblies and fissionable material at or near criticality in order to explore reactivity phenomena, and to operate the assemblies in the regions from subcritical through delayed critical. One critical assembly, Godiva-IV, is designed to operate above prompt critical. The Nuclear Criticality Experimental Research Center (NCERC) is our nation’s only general-purpose critical experiments facility and is only one of a few that remain operational throughout the world. This presentation discusses the history of NCERC, the general activities that makeup work at NCERC, and the various government programs and missions that NCERC supports. Recent activities at NCERC will be reviewed, with a focus on demonstrating how NCERC meets national security mission goals using engineering fundamentals. In particular, there will be a focus on engineering theory and design and applications of engineering fundamentals at NCERC. NCERC activities that relate to engineering education will also be examined.

  6. Experimental research of digital holographic microscopic measuring

    Science.gov (United States)

    Zhu, Xueliang; Chen, Feifei; Li, Jicheng

    2013-06-01

    Digital holography is a new imaging technique, which is developed on the base of optical holography, Digital processing, and Computer techniques. It is using CCD instead of the conventional silver to record hologram, and then reproducing the 3D contour of the object by the way of computer simulation. Compared with the traditional optical holographic, the whole process is of simple measuring, lower production cost, faster the imaging speed, and with the advantages of non-contact real-time measurement. At present, it can be used in the fields of the morphology detection of tiny objects, micro deformation analysis, and biological cells shape measurement. It is one of the research hot spot at home and abroad. This paper introduced the basic principles and relevant theories about the optical holography and Digital holography, and researched the basic questions which influence the reproduce images in the process of recording and reconstructing of the digital holographic microcopy. In order to get a clear digital hologram, by analyzing the optical system structure, we discussed the recording distance and of the hologram. On the base of the theoretical studies, we established a measurement and analyzed the experimental conditions, then adjusted them to the system. To achieve a precise measurement of tiny object in three-dimension, we measured MEMS micro device for example, and obtained the reproduction three-dimensional contour, realized the three dimensional profile measurement of tiny object. According to the experiment results consider: analysis the reference factors between the zero-order term and a pair of twin-images by the choice of the object light and the reference light and the distance of the recording and reconstructing and the characteristics of reconstruction light on the measurement, the measurement errors were analyzed. The research result shows that the device owns certain reliability.

  7. Alternatives to animal experimentation in basic research.

    Science.gov (United States)

    Gruber, Franz P; Hartung, Thomas

    2004-01-01

    In contrast to animal testing required by law to guarantee minimum safety standards for the licensing of drugs and chemicals, there are no regulations in basic research forcing scientists to perform animal tests. By (usually) free choice, questions are posed and hypotheses are examined which, in many cases, can only be answered by means of animal tests. Just as easily, different questions could be asked or different hypotheses could be examined which do not require animal tests. The only criterion for the choice of a topic is its relevance which cannot necessarily be judged in the short-term. Thus, it is up to the individual scientist to judge what is worth studying and therefore worth animal consumption. The educated mind will consider ethical aspects of this choice. However, on the other hand, this decision is largely influenced by questions of efficacy or (in a negative sense) by the obstacles posed to an animal consuming approach. Here, peer review and general attitude will strongly influence the methodology chosen. Availability and awareness of adequate in vitro techniques represent the prerequisites for the use of alternative methods. The least one can do in basic research is to avoid tests which cause severe suffering to animals, as is required in Switzerland and other European countries by binding ethical principles and guidelines. The increasing standard of approval and control procedures has improved the situation over the years. There are many examples of successful alternative methods in basic research. But, the application of such methods is in most cases limited to the laboratories in which they were developed, calling for technology transfer. Exceptions are procedures that are used worldwide, like the production of monoclonal antibodies, which instead of using the ascites mouse can also be performed in vitro with some good will. In these cases, commercialisation of the techniques has aided their spread within the scientific community. Sadly, many

  8. In silico studies in drug research against neurodegenerative diseases.

    Science.gov (United States)

    Makhouri, Farahnaz Rezaei; Ghasemi, Jahan B

    2017-08-22

    Neurodegenerative diseases such as Alzheimer's disease (AD), progressive neurodegenerative forms of Huntington's disease, Parkinson's disease (PD), amyotrophic lateral sclerosis, spinal cerebellar ataxias, and spinal and bulbar muscular atrophy are described by slow and selective dysfunction and degeneration of neurons and axons in the central nervous system (CNS). Computer-aided or in silico design methods have matured into powerful tools for reducing the number of ligands that should be screened in experimental assays. In the present review, the authors provide a basic background about neurodegenerative diseases and in silico techniques in the drug research. Furthermore, they review the various in silico studies reported against various targets in neurodegenerative diseases, including homology modeling, molecular docking, virtual high-throughput screening, quantitative structure activity relationship (QSAR), hologram quantitative structure activity relationship (HQSAR), 3D pharmacophore mapping, proteochemometrics modeling (PCM), fingerprints, fragment-based drug discovery, Monte Carlo simulation, molecular dynamic (MD) simulation, quantum-mechanical methods for drug design, support vector machines, and machine learning approaches. Neurodegenerative diseases have a multifactorial pathoetiological origin, so scientists have become persuaded that a multi-target therapeutic strategy aimed at the simultaneous targeting of multiple proteins (and therefore etiologies) involved in the development of a disease is recommended in future. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  9. Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research

    Directory of Open Access Journals (Sweden)

    Tiago Mendes

    2017-01-01

    Full Text Available Strongyloidiasis is a parasitic neglected disease caused by the nematode Strongyloides stercoralis affecting 30 to 100 million people worldwide. Complications, strongly associated with alcoholism, organ transplants, and HTLV-1 virus, often arise due to late diagnosis, frequently leading to patient death. Lack of preemptive diagnosis is not the only difficulty when dealing with this parasite, since there are no gold standard diagnostic techniques, and the ones used have problems associated with sensitivity, resulting in false negatives. Treatment is also an issue as ivermectin and benzimidazoles administration leads to inconsistent cure rates and several side effects. Researching new anti-Strongyloides drugs is a difficult task since S. stercoralis does not develop until the adult stages in Mus musculus (with the exception of SCID mice, the main experimental host model. Fortunately, alternative parasite models can be used, namely, Strongyloides ratti and S. venezuelensis. However, even with these models, there are other complications in finding new drugs, which are associated with specific in vitro assay protocol steps, such as larvae decontamination. In this review, we highlight the challenges associated with new drug search, the compounds tested, and a list of published in vitro assay methodologies. We also point out advances being made in strongyloidiasis diagnosis so far.

  10. 21 CFR 201.129 - Drugs; exemption for radioactive drugs for research use.

    Science.gov (United States)

    2010-04-01

    ... to human research subjects during the course of a research project intended to obtain basic research... labeled drug or regarding human physiology, pathophysiology, or biochemistry (but not intended for...

  11. Research Highlights: Helping Adolescents Resist Drugs

    National Research Council Canada - National Science Library

    2000-01-01

    Project ALERT departs boldly from prevention models of the 196Os and 197Os, which emphasized informing adolescents about the long-term consequences of drug use or building their decisionmaking skills...

  12. 76 FR 45268 - Center for Drug Evaluation and Research, Approach to Addressing Drug Shortage; Public Workshop

    Science.gov (United States)

    2011-07-28

    ...] Center for Drug Evaluation and Research, Approach to Addressing Drug Shortage; Public Workshop AGENCY... Administration (FDA) is announcing a public workshop regarding the approach of the Center for Drug Evaluation and..., and to gain additional insight from, professional societies, patient advocates, industry, consumer...

  13. Drugs and Crime: The Relationship of Drug Use and Concomitant Criminal Behavior. Research Issues 17.

    Science.gov (United States)

    Austin, Gregory A., Ed.; Lettieri, Dan J., Ed.

    This volume of abstracts of major research and theoretical studies dealing with the relationship between drug use, criminal behavior and the law is concerned with criminal acts other than the possession of, or trafficking in, illicit drugs. Included are 107 selected studies categorized into seven major topic areas: Reviews and Theories, Drug Use…

  14. The evolution of drug design at Merck Research Laboratories.

    Science.gov (United States)

    Brown, Frank K; Sherer, Edward C; Johnson, Scott A; Holloway, M Katharine; Sherborne, Bradley S

    2017-03-01

    On October 5, 1981, Fortune magazine published a cover article entitled the "Next Industrial Revolution: Designing Drugs by Computer at Merck". With a 40+ year investment, we have been in the drug design business longer than most. During its history, the Merck drug design group has had several names, but it has always been in the "design" business, with the ultimate goal to provide an actionable hypothesis that could be tested experimentally. Often the result was a small molecule but it could just as easily be a peptide, biologic, predictive model, reaction, process, etc. To this end, the concept of design is now front and center in all aspects of discovery, safety assessment and early clinical development. At present, the Merck design group includes computational chemistry, protein structure determination, and cheminformatics. By bringing these groups together under one umbrella, we were able to align activities and capabilities across multiple research sites and departments. This alignment from 2010 to 2016 resulted in an 80% expansion in the size of the department, reflecting the increase in impact due to a significant emphasis across the organization to "design first" along the entire drug discovery path from lead identification (LID) to first in human (FIH) dosing. One of the major advantages of this alignment has been the ability to access all of the data and create an adaptive approach to the overall LID to FIH pathway for any modality, significantly increasing the quality of candidates and their probability of success. In this perspective, we will discuss how we crafted a new strategy, defined the appropriate phenotype for group members, developed the right skillsets, and identified metrics for success in order to drive continuous improvement. We will not focus on the tactical implementation, only giving specific examples as appropriate.

  15. The evolution of drug design at Merck Research Laboratories

    Science.gov (United States)

    Brown, Frank K.; Sherer, Edward C.; Johnson, Scott A.; Holloway, M. Katharine; Sherborne, Bradley S.

    2017-03-01

    On October 5, 1981, Fortune magazine published a cover article entitled the "Next Industrial Revolution: Designing Drugs by Computer at Merck". With a 40+ year investment, we have been in the drug design business longer than most. During its history, the Merck drug design group has had several names, but it has always been in the "design" business, with the ultimate goal to provide an actionable hypothesis that could be tested experimentally. Often the result was a small molecule but it could just as easily be a peptide, biologic, predictive model, reaction, process, etc. To this end, the concept of design is now front and center in all aspects of discovery, safety assessment and early clinical development. At present, the Merck design group includes computational chemistry, protein structure determination, and cheminformatics. By bringing these groups together under one umbrella, we were able to align activities and capabilities across multiple research sites and departments. This alignment from 2010 to 2016 resulted in an 80% expansion in the size of the department, reflecting the increase in impact due to a significant emphasis across the organization to "design first" along the entire drug discovery path from lead identification (LID) to first in human (FIH) dosing. One of the major advantages of this alignment has been the ability to access all of the data and create an adaptive approach to the overall LID to FIH pathway for any modality, significantly increasing the quality of candidates and their probability of success. In this perspective, we will discuss how we crafted a new strategy, defined the appropriate phenotype for group members, developed the right skillsets, and identified metrics for success in order to drive continuous improvement. We will not focus on the tactical implementation, only giving specific examples as appropriate.

  16. Experimental and computational prediction of glass transition temperature of drugs.

    Science.gov (United States)

    Alzghoul, Ahmad; Alhalaweh, Amjad; Mahlin, Denny; Bergström, Christel A S

    2014-12-22

    Glass transition temperature (Tg) is an important inherent property of an amorphous solid material which is usually determined experimentally. In this study, the relation between Tg and melting temperature (Tm) was evaluated using a data set of 71 structurally diverse druglike compounds. Further, in silico models for prediction of Tg were developed based on calculated molecular descriptors and linear (multilinear regression, partial least-squares, principal component regression) and nonlinear (neural network, support vector regression) modeling techniques. The models based on Tm predicted Tg with an RMSE of 19.5 K for the test set. Among the five computational models developed herein the support vector regression gave the best result with RMSE of 18.7 K for the test set using only four chemical descriptors. Hence, two different models that predict Tg of drug-like molecules with high accuracy were developed. If Tm is available, a simple linear regression can be used to predict Tg. However, the results also suggest that support vector regression and calculated molecular descriptors can predict Tg with equal accuracy, already before compound synthesis.

  17. Drug Delivery Research: The Invention Cycle.

    Science.gov (United States)

    Park, Kinam

    2016-07-05

    Controlled drug delivery systems have been successful in introducing improved formulations for better use of existing drugs and novel delivery of biologicals. The initial success of producing many oral products and some injectable depot formulations, however, reached a plateau, and the progress over the past three decades has been slow. This is likely due to the difficulties of formulating hydrophilic, high molecular weight drugs, such as proteins and nucleic acids, for targeting specific cells, month-long sustained delivery, and pulsatile release. Since the approaches that have served well for delivery of small molecules are not applicable to large molecules, it is time to develop new methods for biologicals. The process of developing future drug delivery systems, termed as the invention cycle, is proposed, and it starts with clearly defining the problems for developing certain formulations. Once the problems are well-defined, creative imagination examines all potential options and selects the best answer and alternatives. Then, innovation takes over to generate unique solutions for developing new formulations that resolve the previously identified problems. Ultimately, the new delivery systems will have to go through a translational process to produce the final formulations for clinical use. The invention cycle also emphasizes examining the reasons for success of certain formulations, not just the reasons for failure of many systems. Implementation of the new invention cycle requires new mechanisms of funding the younger generation of scientists and a new way of identifying their achievements, thereby releasing them from the burden of short-termism.

  18. Drug knowledge bases and their applications in biomedical informatics research.

    Science.gov (United States)

    Zhu, Yongjun; Elemento, Olivier; Pathak, Jyotishman; Wang, Fei

    2018-01-03

    Recent advances in biomedical research have generated a large volume of drug-related data. To effectively handle this flood of data, many initiatives have been taken to help researchers make good use of them. As the results of these initiatives, many drug knowledge bases have been constructed. They range from simple ones with specific focuses to comprehensive ones that contain information on almost every aspect of a drug. These curated drug knowledge bases have made significant contributions to the development of efficient and effective health information technologies for better health-care service delivery. Understanding and comparing existing drug knowledge bases and how they are applied in various biomedical studies will help us recognize the state of the art and design better knowledge bases in the future. In addition, researchers can get insights on novel applications of the drug knowledge bases through a review of successful use cases. In this study, we provide a review of existing popular drug knowledge bases and their applications in drug-related studies. We discuss challenges in constructing and using drug knowledge bases as well as future research directions toward a better ecosystem of drug knowledge bases. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Design Issues and Inference in Experimental L2 Research

    Science.gov (United States)

    Hudson, Thom; Llosa, Lorena

    2015-01-01

    Explicit attention to research design issues is essential in experimental second language (L2) research. Too often, however, such careful attention is not paid. This article examines some of the issues surrounding experimental L2 research and its relationships to causal inferences. It discusses the place of research questions and hypotheses,…

  20. Future Challenges and Opportunities in Online Prescription Drug Promotion Research

    Science.gov (United States)

    Southwell, Brian G.; Rupert, Douglas J.

    2016-01-01

    Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to conventional broadcast and print advertising and ways in which it differs. We also highlight five key areas for future research: branded drug website influence on consumer knowledge and behavior, interactive features on branded drug websites, mobile viewing of branded websites and mobile advertisements, online promotion and non-US audiences, and social media and medication decisions. PMID:26927597

  1. PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, J.S.; Volkow, N.D.; Ding, Y.S.; Logan, J.; Wang, G.J.

    2001-01-29

    There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement of drugs as well as their effects on the human brain

  2. Advances in drug metabolism and pharmacogenetics research in Australia.

    Science.gov (United States)

    Mackenzie, Peter I; Somogyi, Andrew A; Miners, John O

    2017-02-01

    Metabolism facilitates the elimination, detoxification and excretion in urine or bile (as biotransformation products) of a myriad of structurally diverse drugs and other chemicals. The metabolism of drugs, non-drug xenobiotics and many endogenous compounds is catalyzed by families of drug metabolizing enzymes (DMEs). These include the hemoprotein-containing cytochromes P450, which function predominantly as monooxygenases, and conjugation enzymes that transfer a sugar, sulfate, acetate or glutathione moiety to substrates containing a suitable acceptor functional group. Drug and chemical metabolism, especially the enzymes that catalyse these reactions, has been the research focus of several groups in Australia for over four decades. In this review, we highlight the role of recent and current drug metabolism research in Australia, including elucidation of the structure and function of enzymes from the various DME families, factors that modulate enzyme activity in humans (e.g. drug-drug interactions, gene expression and genetic polymorphism) and the application of in vitro approaches for the prediction of drug metabolism parameters in humans, along with the broader pharmacological/clinical pharmacological and toxicological significance of drug metabolism and DMEs and their relevance to drug discovery and development, and to clinical practice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Minimizing Experimental Error in Thinning Research

    Science.gov (United States)

    C. B. Briscoe

    1964-01-01

    Many diverse approaches have been made prescribing and evaluating thinnings on an objective basis. None of the techniques proposed hasbeen widely accepted. Indeed. none has been proven superior to the others nor even widely applicable. There are at least two possible reasons for this: none of the techniques suggested is of any general utility and/or experimental error...

  4. Studies in youth, drug and alcohol consumption at the Centre for Alcohol and Drug Research

    DEFF Research Database (Denmark)

    Kolind, Torsten; Demant, Jakob Johan; Hunt, Geoffrey

    2013-01-01

    or providing genuine contribution to the sociological analysis and understanding of youth cultures. From the mid-00 s and forward however, a range of analytical tools were developed at Centre for Alcohol and Drug Research (CRF) in order to understand the relationship between youth, drug and alcohol use......Background: During the 90 s and especially in the beginning of the 00 s research in youth, drug and alcohol consumption increased markedly in Denmark. Much of this research was applied and placed in a dilemma between reproducing existing social problem characterizations of youthful behaviors...... and to move beyond the applied perspective into a more social science analytical approach. Aim: The article investigates the relationship developments between drug and alcohol research and youth research in Denmark in general, with a special focus on research conducted at CRF. Specifically, we will focus...

  5. Toward a Holistic Federated Future Internet Experimentation Environment: The Experience of NOVI Research and Experimentation

    NARCIS (Netherlands)

    Maglaris, V.; Papagianni, C.; Androulidakis, G.; Grammatikou, M.; Grosso, P.; van der Ham, J.; de Laat, C.; Pietrzak, B.; Belter, B.; Steger, J.; Laki, S.; Campanella, M.; Sallent, S.

    This article presents the design and pilot implementation of a suite of intelligent methods, algorithms, and tools for federating heterogeneous experimental platforms (domains) toward a holistic Future Internet experimentation ecosystem. The proposed framework developed within the NOVI research and

  6. A new look at lipid-membrane structure in relation to drug research

    DEFF Research Database (Denmark)

    Mouritsen, Ole G.; Jørgensen, Kent

    1998-01-01

    Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design...... of new drugs and drug-delivery systems therefore requries insight into the physical properties of lipid-bilayer membranes. This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental...... and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly, and lipid-bilayer permeability. It is argued that lipids play a major role in lipid membrane-organization and functionality....

  7. Ethnographic and Experimental Hypotheses in Educational Research

    Science.gov (United States)

    Overholt, George E.; Stallings, William M.

    1976-01-01

    Attempts to demonstrate that the ethnographic hypothesis is both culturally relevant and empirically grounded. It is noted that any hypothesis which lacks these attributes is inappropriate for cross cultural research. (Author/AM)

  8. Experimental research concerning waste co-combustion

    Energy Technology Data Exchange (ETDEWEB)

    Ionel, I.

    2007-07-01

    The paper focuses on a lab facility designed for the co-combustion of low calorific Lignite with waste. Also a technology for the potential removal of principal pollutants such as NO{sub x}, Hg and SO{sub 2}, including particles in the fuel gases is described. The novelty of the paper consists in the lay out of the experimental rigs, as well as the application of renewable energy resource in order to generate energy, with lower CO{sub 2} emission. (orig.)

  9. Experimental research of reactor core flooding

    International Nuclear Information System (INIS)

    Blaha, V.; Kotrnoch, J.; Krett, V.

    1978-01-01

    The results are presented of experiments performed with the aim of finding the influence of the method of fixing the thermocouples for measuring the distribution of temperature to the wall of fuel pin simulator. This influence was found for the purpose of emergency core flooding. First experimental results on the effect of nitrogen dissolved in the water on the velocity of the cooling wave are given. These experiments were carried out under the following conditions: initial temperature in pin centre 300 to 600 degC, velocity of water at the inlet into the measuring section 3.5 to 20 cm/s, and atmospheric pressure in the model. (author)

  10. Development and Characterization of Nanoembedded Microparticles for Pulmonary Delivery of Antitubercular Drugs against Experimental Tuberculosis.

    Science.gov (United States)

    Goyal, Amit Kumar; Garg, Tarun; Rath, Goutam; Gupta, Umesh Datta; Gupta, Pushpa

    2015-11-02

    The foremost objective of the present research study was to develop and evaluate the potential of rifampicin (RIF) and isoniazid (INH) loaded spray dried nanoembedded microparticles against experimental tuberculosis (TB). In this study, RIF-INH loaded various formulations (chitosan, guar gum, mannan, and guar gum coated chitosan) were prepared by spray drying and characterized on the basis of in vitro as well as in vivo studies. Results showed that guar gum spray dried particles showed uniform size distribution with smooth surface as compare to mannan formulations. Guar gum batches exhibited excellent flow ability attributed to their optimum moisture content and uniform size distribution. The drug release showed the biphasic pattern of release, i.e., initial burst followed by a sustained release pattern. The preferential uptake of guar gum coated formulations suggested the presence and selective uptake capability of mannose moiety to the specific cell surface of macrophages. In vivo lung distribution study showed that guar gum coated chitosan (GCNP) batches demonstrated prolonged residence at the target site and thereby improve the therapeutic utility of drug with a significant reduction in systemic toxicity. Optimized drug loaded GCNP formulation has resulted in almost 5-fold reduction of the number of bacilli as compared to control group. Histopathology study also demonstrated that none of the treated groups show any evidence of lung tissue abnormality. Hence, GCNPs could be a promising carrier for selective delivery of antitubercular drugs to alveolar macrophages with the interception of minimal side effects, for efficient management of TB.

  11. Research Ethics and Commercial Drug Development: When Integrity Threatens Profitability

    Directory of Open Access Journals (Sweden)

    Bélisle Pipon, Jean-Christophe

    2016-05-01

    Full Text Available This case, based on personal experiences and on those found in the literature, highlights the delicate tension faced by drug development companies having to balance research integrity and their profitability.

  12. Mesoporous Silica Molecular Sieve based Nanocarriers: Transpiring Drug Dissolution Research.

    Science.gov (United States)

    Pattnaik, Satyanarayan; Pathak, Kamla

    2017-01-01

    Improvement of oral bioavailability through enhancement of dissolution for poorly soluble drugs has been a very promising approach. Recently, mesoporous silica based molecular sieves have demonstrated excellent properties to enhance the dissolution velocity of poorly water-soluble drugs. Current research in this area is focused on investigating the factors influencing the drug release from these carriers, the kinetics of drug release and manufacturing approaches to scale-up production for commercial manufacture. This comprehensive review provides an overview of different methods adopted for synthesis of mesoporous materials, influence of processing factors on properties of these materials and drug loading methods. The drug release kinetics from mesoporous silica systems, the manufacturability and stability of these formulations are reviewed. Finally, the safety and biocompatibility issues related to these silica based materials are discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  13. Drug research methodology. Volume 2, The identification of drugs of interest in highway safety

    Science.gov (United States)

    1980-03-01

    This report presents findings of a workshop on the identification of drugs that should be the focus of near-term highway safety research. Drugs of interest are those that have a potential to increase the likelihood of traffic crashes and their attend...

  14. Leakages and pressure relation: an experimental research

    Directory of Open Access Journals (Sweden)

    F. De Paola

    2012-11-01

    Full Text Available Leaks in water systems are presently a frequent and increasing event that involves cost increase and poor service, not compliant to quality standards and modern management criteria. The most recent data available in Italy, resumed into the report issued by Control Committee for Water Resources Use (CONVIRI, shows leakages with an average value of 37%. It is therefore important, for maintenance perspective, to investigate occurrence and evolution of water leaks and the analytical link between leaks Qp and network pressure P, for a reliable calibration of water networks quali-quantitative simulation models. The present work reports the first results of an experimental campaign started at Laboratory of Hydraulics of Department of Hydraulics, Geotechnical and Environmental Engineering of University of Naples Federico II in order to analyze the features of Qp(P relation, which are compared with other results issued in literature.

  15. Experimental Research in Boost Driver with EDLCs

    Science.gov (United States)

    Matsumoto, Hirokazu

    The supply used in servo systems tends to have a high voltage in order to reduce loss and improve the response of motor drives. We propose a new boost motor driver that comprises EDLCs. The proposed driver has a simple structure, wherein the EDLCs are connected in series to the supply, and comprises a charge circuit to charge the EDLCs. The proposed driver has three advantages over conventional boost drivers. The first advantage is that the driver can easily attain the stable boost voltage. The second advantage is that the driver can reduce input power peaks. In a servo system, the input power peaks become greater than the rated power in order to accelerate the motor rapidly. This implies that the equipments that supply power to servo systems must have sufficient power capacity to satisfy the power peaks. The proposed driver can suppress the increase of the power capacity of supply facilities. The third advantage is that the driver can store almost all of the regenerative energy. Conventional drivers have a braking resistor to suppress the increase in the DC link voltage. This causes a considerable reduction in the efficiency. The proposed driver is more efficient than conventional drivers. In this study, the experimental results confirmed the effectiveness of the proposed driver and showed that the drive performance of the proposed driver is the same as that of a conventional driver. Furthermore, it was confirmed that the results of the simulation of a model of the EDLC module, whose capacitance is dependent on the frequency, correspond well with the experimental results.

  16. Prescription drugs for human use generally recognized as safe and effective and not misbranded: drugs used in research: radioactive drugs for certain research uses; amended reporting requirements

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    This amendment revises the reporting requirements for research studies in which radioactive drugs are used. It deletes the requirement for detailed measurements and calculations for each subject in the study; instead, it permits submission of data on a representative subject. The effect will be to decrease the burden in reporting required of the Radioactive Drug Research Committee, but still provide the agency with data to evaluate the risk attributable to radioactive drugs

  17. Experimental research of a microjet cavitation

    Directory of Open Access Journals (Sweden)

    Olšiak Róbert

    2012-04-01

    Full Text Available The paper presents some results of a cavitation research behind a micro-orifice. Investigated were the conditions of the origin of cavitation represented by parameters such as upstream pressure, downstream pressure, liquid temperature and cavitation number. Presented are also images of a cavitating microjet made by the high speed high definition camera RedLake Y3. Dimensions of a microjet are: diameter 0,3 mm; length 0,5 mm.

  18. Open source drug discovery--a new paradigm of collaborative research in tuberculosis drug development.

    Science.gov (United States)

    Bhardwaj, Anshu; Scaria, Vinod; Raghava, Gajendra Pal Singh; Lynn, Andrew Michael; Chandra, Nagasuma; Banerjee, Sulagna; Raghunandanan, Muthukurussi V; Pandey, Vikas; Taneja, Bhupesh; Yadav, Jyoti; Dash, Debasis; Bhattacharya, Jaijit; Misra, Amit; Kumar, Anil; Ramachandran, Srinivasan; Thomas, Zakir; Brahmachari, Samir K

    2011-09-01

    It is being realized that the traditional closed-door and market driven approaches for drug discovery may not be the best suited model for the diseases of the developing world such as tuberculosis and malaria, because most patients suffering from these diseases have poor paying capacity. To ensure that new drugs are created for patients suffering from these diseases, it is necessary to formulate an alternate paradigm of drug discovery process. The current model constrained by limitations for collaboration and for sharing of resources with confidentiality hampers the opportunities for bringing expertise from diverse fields. These limitations hinder the possibilities of lowering the cost of drug discovery. The Open Source Drug Discovery project initiated by Council of Scientific and Industrial Research, India has adopted an open source model to power wide participation across geographical borders. Open Source Drug Discovery emphasizes integrative science through collaboration, open-sharing, taking up multi-faceted approaches and accruing benefits from advances on different fronts of new drug discovery. Because the open source model is based on community participation, it has the potential to self-sustain continuous development by generating a storehouse of alternatives towards continued pursuit for new drug discovery. Since the inventions are community generated, the new chemical entities developed by Open Source Drug Discovery will be taken up for clinical trial in a non-exclusive manner by participation of multiple companies with majority funding from Open Source Drug Discovery. This will ensure availability of drugs through a lower cost community driven drug discovery process for diseases afflicting people with poor paying capacity. Hopefully what LINUX the World Wide Web have done for the information technology, Open Source Drug Discovery will do for drug discovery. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Experimental Research on Fluid Coupling Flexible Actuator

    Directory of Open Access Journals (Sweden)

    Xiangli Zeng

    2018-02-01

    Full Text Available In the field of micromechanics, piezoelectric actuator has attracted great attention for its high-frequency response, high displacement resolution, and high output force. However, its prospect of practical application has been largely limited by the displacement of micrometer. A fluid coupling flexible actuator was proposed, which utilizes resonance to enlarge the output displacement. The actuator uses a piezoelectric oscillator as an excitation source, fluid as the transmission medium and a flexible diaphragm for the displacement output. On the condition that the fluid is inviscid and incompressible, mathematical formulation of the membrane vibration theory has been analyzed. Then, the prototype is made. The displacement is amplified 21 times to 1.106 mm when driving frequency is 127 Hz. The flexible diaphragm appears the largest displacement output when driving frequency is close to one of the system’s natural frequency. Then, the points with zero amplitude form a circle on the surface of flexible diaphragm and the movement direction of the flexible diaphragm is opposite on different sides of the circle. In fact, rather than vibrates at the first resonance frequency, the membrane in the essay is vibrating at a certain higher-order resonance frequency. The experimental results are mainly consistent with the theoretical analysis.

  20. Research Directions for Cyber Experimentation: Workshop Discussion Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    DeWaard, Elizabeth [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Deccio, Casey [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fritz, David Jakob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tarman, Thomas D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories hosted a workshop on August 11, 2017 entitled "Research Directions for Cyber Experimentation," which focused on identifying and addressing research gaps within the field of cyber experimentation , particularly emulation testbeds . This report mainly documents the discussion toward the end of the workshop, which included research gaps such as developing a sustainable research infrastructure, exp anding cyber experimentation, and making the field more accessible to subject matter experts who may not have a background in computer science . Other gaps include methodologies for rigorous experimentation, validation, and uncertainty quantification, which , if addressed, also have the potential to bridge the gap between cyber experimentation and cyber engineering. Workshop attendees presented various ways to overcome these research gaps, however the main conclusion for overcoming these gaps is better commun ication through increased workshops, conferences, email lists, and slack chann els, among other opportunities.

  1. Experimental and theoretical high energy physics research

    International Nuclear Information System (INIS)

    1992-01-01

    Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e + e - analysis, bar P decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the φ factory project; (III) theoretical high-energy physics; (IV) H dibaryon search, search for K L 0 → π 0 γγ and π 0 ν bar ν, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R ampersand D

  2. Experimental research on pedestrian lower leg impact

    Science.gov (United States)

    Constantin, B. A.; Iozsa, D. M.; Stan, C.

    2017-10-01

    The present paper is centred on the research of deceleration measured at the level of the lower leg during a pedestrian impact in multiple load cases. Basically, the used methodology for physical test setup is similar to EuroNCAP and European Union regulatory requirements. Due cost reduction reasons, it was not used a pneumatic system in order to launch the lower leg impactor in the direction of the vehicle front-end. During the test it was used an opposite solution, namely the vehicle being in motion, aiming the standstill lower leg impactor. The impactor has similar specifications to those at EU level, i.e. dimensions, materials, and principle of measurement of the deceleration magnitude. Therefore, all the results obtained during the study comply with the requirements of both EU regulation and EuroNCAP. As a limitation, due to unavailability of proper sensors in the equipment of the lower leg impactor, that could provide precise results, the bending angle, the shearing and the detailed data at the level of knee ligaments were not evaluated. The knee joint should be improved for future studies as some bending angles observed during the post processing of several impact video files were too high comparing to other studies. The paper highlights the first pedestrian impact physical test conducted by the author, following an extensive research in the field. Deceleration at the level of pedestrian knee can be substantially improved by providing enough volume between the bumper fascia and the front-end structure and by using pedestrian friendly materials for shock absorbers, such as foams.

  3. How do researchers categorize drugs, and how do drug users categorize them?

    Science.gov (United States)

    Lee, Juliet P; Antin, Tamar M J

    2012-01-01

    This paper considers drug classifications and terms widely used in US survey research, and compares these to classifications and terms used by drug users. We begin with a critical review of drug classification systems, including those oriented to public policy and health services as well as survey research. We then consider the results of a pile sort exercise we conducted with 76 respondents within a mixed method study of Southeast Asian American adolescent and young adult drug users in urban Northern California, USA. We included the pile sort to clarify how respondents handled specific terms which we understood to be related to Ecstasy and methamphetamines. Results of the pile sort were analyzed using graphic layout algorithms as well as content analysis of pile labels. Similar to the national surveys, our respondents consistently differentiated Ecstasy terms from methamphetamine terms. We found high agreement between some specific local terms ( thizz , crystal ) and popular drug terms, while other terms thought to be mainstream ( crank , speed ) were reported as unknown by many respondents. In labeling piles, respondents created taxonomies based on consumption method (in particular, pill ) as well as the social contexts of use. We conclude by proposing that divergences between drug terms utilized in survey research and those used by drug users may reflect two opposing tendencies: the tendency of survey researchers to utilize standardized language that constructs persons and experiences as relatively homogeneous, varying only within measurable degrees, and the tendency of drug users to utilize specialized language (argot) that reflects their understandings of their experiences as hybrid and diverse. The findings problematize the validity of drug terms and categories used in survey research.

  4. Experimental facility of innovative types as the laboratory analog of research reactor experimental device

    International Nuclear Information System (INIS)

    Androsenko, A.A.; Androsenko, P.A.; Zabud'ko, A.N.; Kremenetskij, A.K.; Nikolaev, A.N.; Trykov, L.A.

    1991-01-01

    The paper analyses capability of creating laboratory analogs of complex experimental facilities at research reactors utilizing power radionuclide neutron sources fabricated in industrial conditions. Some experimental and calculational investigations of neutron-physical characteristics are presented, which have been attained at the RIZ research reactor laboratory analog. Experimental results are supplemented by calculational investigations, fulfilled by means of the BRAND three-dimensional computational complex and the ROZ-6 one-dimensional program. 4 refs.; 3 figs

  5. Experimental and theoretical high energy physics research

    International Nuclear Information System (INIS)

    Cline, D.B.

    1993-01-01

    Progress on seven tasks is reported. (I)UCLA hadronization model, antiproton decay, PEP4/9 e + e - analysis: In addition to these topics, work on CP and CPT phenomenology at a φ factory and letters of support on the hadronization project are included. (II)ICARUS detector and rare B decays with hadron beams and colliders: Developments are summarized and some typcial events as shown; in addition, the RD5 collaboration at CERN and the asymmetric φ factory project are sketched. (III)Theoretical physics: Feynman diagram calculations in gauge theory; supersymmetric standard model; effects of quantum gravity in breaking of global symmetries; models of quark and lepton substructure; renormalized field theory; large-scale structure in the universe and particle-astrophysics/early universe cosmology. (IV)H dibaryon search at BNL, kaon experiments (E799/KTeV) at Fermilab: Project design and some scatterplots are given. (V)UCLA participation in the experiment CDF at Fermilab. (VI)Detectors for hadron physics at ultrahigh energy colliders: Scintillating fiber and visible light photon counter research. (VII)Administrative support and conference organization

  6. Experimental design and instability analysis of coaxial electrospray process for microencapsulation of drugs and imaging agents.

    Science.gov (United States)

    Si, Ting; Zhang, Leilei; Li, Guangbin; Roberts, Cynthia J; Yin, Xiezhen; Xu, Ronald

    2013-07-01

    Recent developments in multimodal imaging and image-guided therapy requires multilayered microparticles that encapsulate several imaging and therapeutic agents in the same carrier. However, commonly used microencapsulation processes have multiple limitations such as low encapsulation efficiency and loss of bioactivity for the encapsulated biological cargos. To overcome these limitations, we have carried out both experimental and theoretical studies on coaxial electrospray of multilayered microparticles. On the experimental side, an improved coaxial electrospray setup has been developed. A customized coaxial needle assembly combined with two ring electrodes has been used to enhance the stability of the cone and widen the process parameter range of the stable cone-jet mode. With this assembly, we have obtained poly(lactide-co-glycolide) microparticles with fine morphology and uniform size distribution. On the theoretical side, an instability analysis of the coaxial electrified jet has been performed based on the experimental parameters. The effects of process parameters on the formation of different unstable modes have been studied. The reported experimental and theoretical research represents a significant step toward quantitative control and optimization of the coaxial electrospray process for microencapsulation of multiple drugs and imaging agents in multimodal imaging and image-guided therapy.

  7. Illicit drugs and the media: models of media effects for use in drug policy research.

    Science.gov (United States)

    Lancaster, Kari; Hughes, Caitlin E; Spicer, Bridget; Matthew-Simmons, Francis; Dillon, Paul

    2011-07-01

    Illicit drugs are never far from the media gaze and although identified almost a decade ago as 'a new battleground' for the alcohol and other drug (AOD) field there has been limited research examining the role of the news media and its effects on audiences and policy. This paper draws together media theories from communication literature to examine media functions. We illustrate how each function is relevant for media and drugs research by drawing upon the existing literature examining Australian media coverage during the late 1990s of escalating heroin-related problems and proposed solutions. Media can influence audiences in four key ways: by setting the agenda and defining public interest; framing issues through selection and salience; indirectly shaping individual and community attitudes towards risk; and feeding into political debate and decision making. Each has relevance for the AOD field. For example, media coverage of the escalating heroin-related problems in Australia played a strong role in generating interest in heroin overdoses, framing public discourse in terms of a health and/or criminal issue and affecting political decisions. Implications AND CONCLUSION: Media coverage in relation to illicit drugs can have multifarious effects. Incorporating media communication theories into future research and actions is critical to facilitate understanding of the short- and long-term impacts of media coverage on illicit drugs and the avenues by which the AOD field can mitigate or inform future media debates on illicit drugs. © 2010 Australasian Professional Society on Alcohol and other Drugs.

  8. Development of anti-inflammatory drugs - the research and development process.

    Science.gov (United States)

    Knowles, Richard Graham

    2014-01-01

    The research and development process for novel drugs to treat inflammatory diseases is described, and several current issues and debates relevant to this are raised: the decline in productivity, attrition, challenges and trends in developing anti-inflammatory drugs, the poor clinical predictivity of experimental models of inflammatory diseases, heterogeneity within inflammatory diseases, 'improving on the Beatles' in treating inflammation, and the relationships between big pharma and biotechs. The pharmaceutical research and development community is responding to these challenges in multiple ways which it is hoped will lead to the discovery and development of a new generation of anti-inflammatory medicines. © 2013 Nordic Pharmacological Society. Published by John Wiley & Sons Ltd.

  9. Experimental and theoretical evaluation of nanodiamonds as pH triggered drug carriers

    KAUST Repository

    Yan, Jingjing; Guo, Yong; Altawashi, Azza; Moosa, Basem; Lecommandoux, Sé bastien; Khashab, Niveen M.

    2012-01-01

    Nanodiamond (ND) and its derivatives have been widely used for drug, protein and gene delivery. Herein, experimental and theoretical methods have been combined to investigate the effect of pH on the delivery of doxorubicin (DOX) from fluorescein

  10. Current knowledge from experimental works with radioprotective drugs from the viewpoint of latest scientific research; Aktualne poznatky z experiment8lnych prac s rastlinami s radioprotektivnym ucinkom vo svetle najnovsich vedeckych vyskumov

    Energy Technology Data Exchange (ETDEWEB)

    Skalka, J [Ustav vyzivy, dietetiky a krmovinarstva, Univerzita veterinarskeho lekarstva, 04181 Kosice (Slovakia)

    2008-06-15

    The protection of both human and animal population against a radiation impairment proves to be an impulse for continuous intensive searching for plants with radioprotective properties, identification of their radioprotective components and examination of their effects both in vivo an in vitro. I am presenting the results as well as knowledge of a latest scientific research in this field with testing the following plants: Vigna radiata, Mentha piperita, Citrus aurantium var. amara, Syzygium cumini, Tinospora cordifolia, Aegle marmelos, Phyllanthus amarus, Aloe vera, Angelica sinensis, Rosemarinus officinalis, Panax ginseng, Hippophae rhamnoides, Ocimum sanctum, Crataegus microphylla. (authors)

  11. 21 CFR 361.1 - Radioactive drugs for certain research uses.

    Science.gov (United States)

    2010-04-01

    ... Research Committee. A Radioactive Drug Research Committee, composed and approved by the Food and Drug... CFR 20.61. Investigator Chairman, Radioactive Drug Research Committee At any time a proposal is... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Radioactive drugs for certain research uses. 361.1...

  12. Theoretical and experimental investigation of drug-polymer interaction and miscibility and its impact on drug supersaturation in aqueous medium.

    Science.gov (United States)

    Baghel, Shrawan; Cathcart, Helen; O'Reilly, Niall J

    2016-10-01

    Amorphous solid dispersions (ASDs) have the potential to offer higher apparent solubility and bioavailability of BCS class II drugs. Knowledge of the solid state drug-polymer solubility/miscibility and their mutual interaction are fundamental requirements for the effective design and development of such systems. To this end, we have carried out a comprehensive investigation of various ASD systems of dipyridamole and cinnarizine in polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) at different drug loadings. Theoretical and experimental examinations (by implementing binary and ternary Flory-Huggins (F-H) theory) related to drug-polymer interaction/miscibility including solubility parameter approach, melting point depression method, phase diagram, drug-polymer interaction in the presence of moisture and the effect of drug loading on interaction parameter were performed. The information obtained from this study was used to predict the stability of ASDs at different drug loadings and under different thermal and moisture conditions. Thermal and moisture sorption analysis not only provided the composition-dependent interaction parameter but also predicted the composition dependent miscibility. DPM-PVP, DPM-PAA and CNZ-PAA systems have shown molecular level mixing over the complete range of drug loading. For CNZ-PVP, the presence of a single Tg at lower drug loadings (10, 20 and 35%w/w) indicates the formation of solid solution. However, drug recrystallization was observed for samples with higher drug weight fractions (50 and 65%w/w). Finally, the role of polymer in maintaining drug supersaturation has also been explored. It has been found that drug-polymer combinations capable of hydrogen-bonding in the solution state (DPM-PVP, DPM-PAA and CNZ-PAA) are more effective in preventing drug crystallization compared to the drug-polymer systems without such interaction (CNZ-PVP). The DPM-PAA system outperformed all other ASDs in various stability conditions (dry-state, in

  13. Formulation, quality control and shelf life of the experimental cytostatic drug cyclopentenyl cytosine

    NARCIS (Netherlands)

    Schimmel, Kirsten; Guchelaar, Henk-Jan; van Kan, Erik

    2006-01-01

    This paper describes the formulation and quality control of an aqueous sterilized formulation of the experimental cytostatic drug cyclopentenyl cytosine (CPEC) to be used in Phase I/II clinical trials. The raw drug substance was extensively tested. A High Pressure Liquid Chromotography (HPLC) method

  14. Nonhuman primate positron emission tomography neuroimaging in drug abuse research.

    Science.gov (United States)

    Howell, Leonard Lee; Murnane, Kevin Sean

    2011-05-01

    Positron emission tomography (PET) neuroimaging in nonhuman primates has led to significant advances in our current understanding of the neurobiology and treatment of stimulant addiction in humans. PET neuroimaging has defined the in vivo biodistribution and pharmacokinetics of abused drugs and related these findings to the time course of behavioral effects associated with their addictive properties. With novel radiotracers and enhanced resolution, PET neuroimaging techniques have also characterized in vivo drug interactions with specific protein targets in the brain, including neurotransmitter receptors and transporters. In vivo determinations of cerebral blood flow and metabolism have localized brain circuits implicated in the effects of abused drugs and drug-associated stimuli. Moreover, determinations of the predisposing factors to chronic drug use and long-term neurobiological consequences of chronic drug use, such as potential neurotoxicity, have led to novel insights regarding the pathology and treatment of drug addiction. However, similar approaches clearly need to be extended to drug classes other than stimulants. Although dopaminergic systems have been extensively studied, other neurotransmitter systems known to play a critical role in the pharmacological effects of abused drugs have been largely ignored in nonhuman primate PET neuroimaging. Finally, the study of brain activation with PET neuroimaging has been replaced in humans mostly by functional magnetic resonance imaging (fMRI). There has been some success in implementing pharmacological fMRI in awake nonhuman primates. Nevertheless, the unique versatility of PET imaging will continue to complement the systems-level strengths of fMRI, especially in the context of nonhuman primate drug abuse research.

  15. Drugs to foster kidney regeneration in experimental animals and humans.

    Science.gov (United States)

    Gagliardini, Elena; Benigni, Ariela

    2014-01-01

    The incidence of kidney diseases is increasing worldwide and they are emerging as a major public health problem. Once mostly considered inexorable, renal disease progression can now be halted and lesions can even regress with drugs such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type I receptor blockers, indicating the possibility of kidney repair. The discovery of renal progenitor cells lining the Bowman capsule of adult rat and human kidneys has shed light on the mechanism of repair by ACEi. Parietal progenitors are a reservoir of cells that contribute to podocyte turnover in physiological conditions. In the early phases of renal disease these progenitors migrate chaotically and subsequently proliferate, accumulating in Bowman's space. The abnormal behavior of parietal progenitors is sustained by the activation of CXCR4 receptors in response to an increased production of the chemokine SDF-1 by podocytes activated by the inflammatory environment. Ang II, via the AT1 receptor, also contributes to progenitor cell proliferation. The CXCR4/SDF-1 and Ang II/AT1 receptor pathogenic pathways both pave the way for lesion formation and subsequent sclerosis. ACEi normalize the CXCR4 and AT1 receptor expression on progenitors, limiting their proliferation, concomitant with the regression of hyperplastic lesions in animals, and in a patient with crescentic glomerulopathy. Understanding the molecular and cellular determinants of regeneration triggered by renoprotective drugs will reveal novel pathways that might be challenged or targeted by pharmacological therapy. © 2014 S. Karger AG, Basel.

  16. Perspectives of experimental nuclear physics research at RBI Croatia

    International Nuclear Information System (INIS)

    Soic, N.

    2009-01-01

    Experimental nuclear physics has been one of the top research activities at the Rudjer Boskovic Institute, the largest and leading Croatian research center in science and applications. The RBI nuclear physics group has strong link with the researchers at the University of Zagreb. RBI scientists perform experiments at the RBI Tandem accelerator facility and at the top European experimental facilities in collaboration with the prominent research groups in the field. Current status of the RBI experimental nuclear physics research and our recent activities aimed to strengthen our position at the RBI and to increase our international reputation and impact in collaborative projects will be presented. Part of these activities is focused on local accelerator facilities, at present mainly used for application research, and their increased usage for nuclear physics research and for development and testing of novel research equipment for large international facilities. Upgrade of the local research equipment is on the way through FP7 REGPOT project 'CLUNA: Clustering phenomena in nuclear physics: strengthening of the Zagreb-Catania-Birmingham partnership'. Recently, steps to exploit potential of the facility for nuclear astrophysics research have been initiated. Possible future actions for further strengthening of the RBI experimental nuclear physics research will be discussed.(author)

  17. 21 CFR 201.125 - Drugs for use in teaching, law enforcement, research, and analysis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drugs for use in teaching, law enforcement, research, and analysis. 201.125 Section 201.125 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... § 201.125 Drugs for use in teaching, law enforcement, research, and analysis. A drug subject to § 201...

  18. Gore offers to help drug companies pursue research.

    Science.gov (United States)

    1996-03-08

    A meeting convened between Vice President Al Gore and executives of leading pharmaceutical companies to determine means of accelerating efforts to develop vaccines, therapeutics, and microbicides for people with HIV. Gore explained that the administration will work with pharmaceutical companies to determine the long-term effectiveness of drugs approved by the Food and Drug Administration (FDA), work with international groups to increase investment in vaccine development, help develop new microbicides for women with HIV, and identify promising areas of AIDS research. According to advocates, the Clinton Administration has made great strides in improving and accelerating the FDA's drug approval process. The next goal of the pharmaceutical research agenda should be to include consumer advocates in the decision-making process.

  19. Can open-source R&D reinvigorate drug research?

    Science.gov (United States)

    Munos, Bernard

    2006-09-01

    The low number of novel therapeutics approved by the US FDA in recent years continues to cause great concern about productivity and declining innovation. Can open-source drug research and development, using principles pioneered by the highly successful open-source software movement, help revive the industry?

  20. Ethnographic research in immigrant-specific drug abuse recovery houses.

    Science.gov (United States)

    Pagano, Anna; Lee, Juliet P; García, Victor; Recarte, Carlos

    2018-01-01

    Access to study populations is a major concern for drug use and treatment researchers. Spaces related to drug use and treatment have varying levels of researcher accessibility based on several issues, including legality, public versus private settings, and insider/outsider status. Ethnographic research methods are indispensable for gaining and maintaining access to hidden or "hard-to-reach" populations. Here, we discuss our long-term ethnographic research on drug abuse recovery houses created by and for Latino migrants and immigrants in Northern California. We take our field work experiences as a case study to examine the problem of researcher access and how ethnographic strategies can be successfully applied to address it, focusing especially on issues of entrée, building rapport, and navigating field-specific challenges related to legality, public/private settings, and insider/outsider status. We conclude that continued funding support for ethnography is essential for promoting health disparities research focused on diverse populations in recovery from substance use disorders.

  1. Research related to roads in USDA experimental forests [Chapter 16

    Science.gov (United States)

    W. J. Elliot; P. J. Edwards; R. B. Foltz

    2014-01-01

    Forest roads are essential in experimental forests and rangelands (EFRs) to allow researchers and the public access to research sites and for fire suppression, timber extraction, and fuel management. Sediment from roads can adversely impact watershed health. Since the 1930s, the design and management of forest roads has addressed both access issues and watershed health...

  2. Failure of antiarrhythmic drugs to prevent experimental reperfusion ventricular fibrillation.

    Science.gov (United States)

    Naito, M; Michelson, E L; Kmetzo, J J; Kaplinsky, E; Dreifus, L S

    1981-01-01

    Ninety-nine adult mongrel dogs underwent acute ligation of the proximal left anterior descending coronary artery. Thirty minutes later, the occlusion was released to evaluate the effectiveness of five antiarrhythmic protocols in eliminating reperfusion ventricular fibrillation. The five protocols included: protocol 1 --i.v. lidocaine, preligation and prerelease (n = 19); protocol 2 -- i.v. lidocaine, prereperfusion only (n = 22); protocol 3 -- chronic, oral, daily amiodarone for 2 weeks preligation (n = 19); protocol 4 -- i.v. procainamide, preligation and prereperfusion (n = 21); and protocol 5 -- i.v. verapamil, prereperfusion (n = 18). Each regimen was evaluated with respect to the incidence of reperfusion ventricular fibrillation in dogs that survived to reperfusion, and the results were compared to 77 control dogs that underwent identical coronary artery occlusion and release procedures without drug therapy. The incidence of reperfusion ventricular fibrillation was as follows: protocol 1 -- seven of 15 dogs (47%); protocol 2 -- six of 18 (33%); protocol 3 -- 11 of 16 dogs (69%); protocol 4 -- eight of 17 dogs (47%); and protocol 5 -- 10 of 17 dogs (59%), compared with 36 of 60 (60%) in control dogs. Using chi-square analysis, protocol 2 was beneficial (p antecedent coronary artery ligation periods, and predictive risk indexes for the occurrence of reperfusion ventricular fibrillation were developed. the Mantel-Haenszel method of statistical analysis revealed that none of these protocols resulted in a statistically significant reduction in the incidence of reperfusion ventricular fibrillation. Thus, use of these predictive indexes plus appropriate statistical methods has revealed, unexpectedly, limitations in the efficacy of a spectrum of antiarrhythmic agents in preventing reperfusion ventricular fibrillation.

  3. [Reduction of animal experiments in experimental drug testing].

    Science.gov (United States)

    Behrensdorf-Nicol, H; Krämer, B

    2014-10-01

    In order to ensure the quality of biomedical products, an experimental test for every single manufactured batch is required for many products. Especially in vaccine testing, animal experiments are traditionally used for this purpose. For example, efficacy is often determined via challenge experiments in laboratory animals. Safety tests of vaccine batches are also mostly performed using laboratory animals. However, many animal experiments have clear inherent disadvantages (low accuracy, questionable transferability to humans, unclear significance). Furthermore, for ethical reasons and animal welfare aspects animal experiments are also seen very critical by the public. Therefore, there is a strong trend towards replacing animal experiments with methods in which no animals are used ("replacement"). If a replacement is not possible, the required animal experiments should be improved in order to minimize the number of animals necessary ("reduction") and to reduce pain and suffering caused by the experiment to a minimum ("refinement"). This "3R concept" is meanwhile firmly established in legislature. In recent years many mandatory animal experiments have been replaced by alternative in vitro methods or improved according to the 3R principles; numerous alternative methods are currently under development. Nevertheless, the process from the development of a new method to its legal implementation takes a long time. Therefore, supplementary regulatory measures to facilitate validation and acceptance of new alternative methods could contribute to a faster and more consequent implementation of the 3R concept in the testing of biomedical products.

  4. In-pile experimental facility needs for LMFR safety research

    International Nuclear Information System (INIS)

    Kawata, Norio; Niwa, Hajime

    1994-01-01

    Although the achievement of the safety research during the past years has been significant, there still exists a strong need for future research, especially when there is prospect for future LMFR commercialization. In this paper, our current views are described on future research needs especially with a new in-pile experimental facility. The basic ideas and progress are outlined of a preliminary feasibility study. (author)

  5. Phosphonic drugs: Experimental and theoretical spectroscopic studies of fosfomycin

    Science.gov (United States)

    Chruszcz-Lipska, Katarzyna; Zborowski, Krzysztof K.; Podstawka-Proniewicz, Edyta; Liu, Shaoxuan; Xu, Yizhuang; Proniewicz, Leonard M.

    2011-02-01

    pH and time-dependant changes of fosfomycin molecular structure in an aqueous solution are studied by Raman, NMR, and generalized 2D correlation spectroscopies. Interpretation of the experimental spectra is based on the assumption of formation of different species running on applied physicochemical conditions. Geometries of all possible structures were entirely optimized with the 6-311++G(2df,p) basis set at the B3LYP theoretical level using procedures implemented in the Gaussian '03 set of programs. Harmonic frequency calculations verified the nature of the studied structures and allowed to simulate obtained Raman spectra. The theoretical NMR shielding was calculated using the GIAO method at the same computational level. In addition, in some cases PCM model was used to monitor the influence of water molecules on the NMR spectra. It is shown that in the pH range of 1-2 of fosfomycin aqueous solution oxirane ring is open sequent to nucleophilic attack and forms 1,2-dihydroxyphosphonic acid with small content of its monodeprotonated species. On the other hand, in pH 7 and higher it appears either as 1,2-epoxypropylphosphonic or 1,2-dihydroxyphosphonic dianion depending upon whether hydrolysis took place or not. It is also discussed that Raman marker bands originating from the individual species of fosfomycin can be used to detect and/or to monitor this antibiotic in an aqueous medium (for example urine samples). Hence, depending upon the structure found in urine one can tell about metabolic processes of this antibiotic in the body.

  6. Recent Activities on the Experimental Research Programme Using Small Tokamaks

    International Nuclear Information System (INIS)

    Gryaznevich, M. P.; Bosco, E. del; Malaquias, A.; Mank, G.; Oost, G. van

    2006-01-01

    A new concept of interactive co-ordinated research using small tokamaks in the mainstream fusion science areas, in testing of new diagnostics, materials and technologies as well as in education, training and broadening of the geography of fusion research in the scope of the IAEA Co-ordinated Research Project (CRP) is discussed in this paper. Besides the presentation of the recent activities on the experimental research programme using small tokamaks and scientific results achieved at the participating laboratories, information is provided about the organisation of the co-ordinated research project. Future plans of the co-ordinated activities within the CRP are discussed

  7. Testimonials and Informational Videos on Branded Prescription Drug Websites: Experimental Study to Assess Influence on Consumer Knowledge and Perceptions.

    Science.gov (United States)

    Sullivan, Helen W; O'Donoghue, Amie C; Gard Read, Jennifer; Amoozegar, Jacqueline B; Aikin, Kathryn J; Rupert, Douglas J

    2018-01-23

    Direct-to-consumer (DTC) promotion of prescription drugs can affect consumer behaviors and health outcomes, and Internet drug promotion is growing rapidly. Branded drug websites often capitalize on the multimedia capabilities of the Internet by using videos to emphasize drug benefits and characteristics. However, it is unknown how such videos affect consumer processing of drug information. This study aimed to examine how videos on prescription drug websites, and the inclusion of risk information in those videos, influence consumer knowledge and perceptions. We conducted an experimental study in which online panel participants with acid reflux (n=1070) or high blood pressure (n=1055) were randomly assigned to view 1 of the 10 fictitious prescription drug websites and complete a short questionnaire. On each website, we manipulated the type of video (patient testimonial, mechanism of action animation, or none) and whether the video mentioned drug risks. Participants who viewed any video were less likely to recognize drug risks presented only in the website text (P≤.01). Including risk information in videos increased participants' recognition of the risks presented in the videos (P≤.01). However, in some cases, including risk information in videos decreased participants' recognition of the risks not presented in the videos (ie, risks presented in text only; P≤.04). Participants who viewed a video without drug risk information thought that the website placed more emphasis on benefits, compared with participants who viewed the video with drug risk information (P≤.01). Compared with participants who viewed a video without drug risk information, participants who viewed a video with drug risk information thought that the drug was less effective in the high blood pressure sample (P=.03) and thought that risks were more serious in the acid reflux sample (P=.01). There were no significant differences between risk and nonrisk video conditions on other perception

  8. [Alternatives to the drug research and development model].

    Science.gov (United States)

    Velásquez, Germán

    2015-03-01

    One-third of the global population lacks access to medications; the situation is worse in poor countries, where up to 50% of the population lacks access. The failure of current incentive systems based in intellectual property to offer the necessary pharmaceutical products, especially in the global south, is a call to action. Problems related to drug access cannot be solved solely through improvements or modifications in the existing incentive models. The intellectual property system model does not offer sufficient innovation for developing countries; new mechanisms that effectively promote innovation and drug access simultaneously are needed. A binding international agreement on research and development, negotiated under the auspices of the World Health Organization, could provide an adequate framework for guaranteeing priority-setting, coordination, and sustainable financing of drugs at reasonable prices for developing countries.

  9. Animal experimentation-Part II: In periodontal research

    Directory of Open Access Journals (Sweden)

    T K Pal

    2015-01-01

    Full Text Available Animals contribute to the development of medical and dental sciences by being sacrificed in the hands of scientists. The experimental design demands a specific type of animal to be used for experimentation. Each animal needs proper handling, care, and diet. Alongside specific advantages and disadvantages pertaining to each type of animal need to be understood well depending on the type of study/experiment. It is important for the researcher to know the disease susceptibility of each animal. The purpose of this paper is to highlight the salient factors that need to be considered for animal experimentations.

  10. Health Services Research for Drug and Alcohol Treatment and Prevention.

    Science.gov (United States)

    McCarty, Dennis; Roman, Paul M; Sorensen, James; Weisner, Constance

    2009-01-01

    Health services research is a multidisciplinary field that examines ways to organize, manage, finance, and deliver high-quality care. This specialty within substance abuse research developed from policy analyses and needs assessments that shaped federal policy and promoted system development in the 1970s. After the authorization of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), patient information systems supported studies of treatment processes and outcomes. Health services research grew substantially in the 1990s when NIAAA and NIDA moved into the National Institutes of Health and legislation allocated 15% of their research portfolio to services research. The next decade will emphasize research on quality of care, adoption and use of evidence-based practices (including medication), financing reforms and integration of substance abuse treatment with primary care and mental health services.

  11. An ethical exploration of barriers to research on controlled drugs

    Science.gov (United States)

    ANDREAE, Michael H; RHODES, Evelyn; BOURGOISE, Tylor; CARTER, George; WHITE, Robert S.; INDYK, Debbie; SACKS, Henry; RHODES, Rosamond

    2016-01-01

    We examine the ethical, social and regulatory barriers that may hamper research on therapeutic potential of certain controversial controlled substances like marijuana, heroin or ketamine. Hazards for individuals and society, and their potential adverse effects on communities may be good reasons for limiting access and justify careful monitoring of certain substances. Overly strict regulations, fear of legal consequences, stigma associated with abuse and populations using illicit drugs, and lack of funding may hinder research on their considerable therapeutic potential. We review the surprisingly sparse literature and address the particular ethical concerns of undue inducement, informed consent, risk to participants, researchers and institutions, justice and liberty germane to the research with illicit and addictive substances. We debate the disparate research stakeholder perspectives and why they are likely to be infected with bias. We propose an empirical research agenda to provide a more evidentiary basis for ethical reasoning. PMID:26982922

  12. Drug repurposing for aging research using model organisms.

    Science.gov (United States)

    Ziehm, Matthias; Kaur, Satwant; Ivanov, Dobril K; Ballester, Pedro J; Marcus, David; Partridge, Linda; Thornton, Janet M

    2017-10-01

    Many increasingly prevalent diseases share a common risk factor: age. However, little is known about pharmaceutical interventions against aging, despite many genes and pathways shown to be important in the aging process and numerous studies demonstrating that genetic interventions can lead to a healthier aging phenotype. An important challenge is to assess the potential to repurpose existing drugs for initial testing on model organisms, where such experiments are possible. To this end, we present a new approach to rank drug-like compounds with known mammalian targets according to their likelihood to modulate aging in the invertebrates Caenorhabditis elegans and Drosophila. Our approach combines information on genetic effects on aging, orthology relationships and sequence conservation, 3D protein structures, drug binding and bioavailability. Overall, we rank 743 different drug-like compounds for their likelihood to modulate aging. We provide various lines of evidence for the successful enrichment of our ranking for compounds modulating aging, despite sparse public data suitable for validation. The top ranked compounds are thus prime candidates for in vivo testing of their effects on lifespan in C. elegans or Drosophila. As such, these compounds are promising as research tools and ultimately a step towards identifying drugs for a healthier human aging. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  13. Addiction research centres and the nurturing of creativity. The Centre for Alcohol and Drug Research: social science alcohol and drug research in Denmark.

    Science.gov (United States)

    Pedersen, Mads U; Elmeland, Karen; Frank, Vibeke A

    2011-12-01

    The purpose of this paper is to introduce the social science alcohol and drug research undertaken by the Centre for Alcohol and Drug Research (CRF) and at the same time offer an insight into the development in Danish alcohol and drug research throughout the past 15-20 years. A review of articles, books and reports published by researcher from CRF from the mid-1990s until today and an analysis of the policy-making in the Danish substance use and misuse area. CRF is a result of the discussions surrounding social, health and allocation policy questions since the mid-1980s. Among other things, these discussions led to the formal establishment of the Centre in 1991 under the Aarhus University, the Faculty of Social Science. Since 2001 the Centre has received a permanent basic allocation, which has made it possible to appoint tenured senior researchers; to work under a more long-term research strategy; to function as a milieu for educating PhD students; and to diversify from commissioned research tasks to initiating projects involving more fundamental research. Research at the Centre is today pivoted around four core areas: consumption, policy, prevention and treatment. The emergence, continuation, financing and character of the research taking place at CRF can be linked closely to the specific Danish drug and alcohol discourse and to the division of the responsibility for alcohol and drug research into separate Ministries. © 2010 The Authors, Addiction © 2010 Society for the Study of Addiction.

  14. Theoretical and Experimental Research of Synchronous Reluctance Motor

    Science.gov (United States)

    Dobriyan, R.; Vitolina, S.; Lavrinovicha, L.; Dirba, J.

    2017-10-01

    The paper presents the research on evaluation of accuracy of magnetic field calculations of synchronous reluctance motor in comparison with the results obtained in experiments. Magnetic field calculations are performed with the finite element method to determine values of the magnetic flux and electromagnetic torque according to the current value in motor stator and load angle between the rotor direct-axis and axis of stator magnetomotive force (MMF). Experimental values of magnetic flux and electromagnetic torque are obtained on motor with locked rotor while equivalent direct current is applied to the stator windings. The research shows that the results obtained from the magnetic field calculations coincide well with the experimental data.

  15. Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Expression Using Experimental Rodent Models

    OpenAIRE

    Canet, Mark J.; Hardwick, Rhiannon N.; Lake, April D.; Dzierlenga, Anika L.; Clarke, John D.; Cherrington, Nathan J.

    2014-01-01

    Nonalcoholic fatty liver disease is a prevalent form of chronic liver disease that can progress to the more advanced stage of nonalcoholic steatohepatitis (NASH). NASH has been shown to alter drug transporter regulation and may have implications in the development of adverse drug reactions. Several experimental rodent models have been proposed for the study of NASH, but no single model fully recapitulates all aspects of the human disease. The purpose of the current study was to determine whic...

  16. Main directions of Research Institute of Experimental and Theoretic Physics

    International Nuclear Information System (INIS)

    Tazhibaeva, I.L.

    1997-01-01

    The characteristic of main directions of the Research Institute of Experimental and Theoretic Physics (RIETF) activity is given in the paper. It is noted, that Institute is headquarters organisation in 4 following scientific programs of Ministry of Science - Academy of Science of Republic of Kazakhstan: Physics and mechanics of gases, plasma and liquid; Theoretical physics; Nonlinear processes and structural self-organization of substance; Research works Comet. Since 1994 RIETF is one of executors on interstate scientific program ITER. There are following priorities in activity of the institute: - actual problems of relativity theory, gravitation and quantum mechanics; - research on combustion problems and heat-mass-transfer; - physics of gases, plasma and liquid; physics non-equilibrium processes in plasma an in plasma-similar media; - solid state physics and material testing problems; modification of materials properties; electrophysical, optical and structural researches of substance; - interactions of nuclear, electromagnet radiation and accelerated particles with substance; - theoretical and experimental nuclear physics and physics of cosmic rays

  17. Managing Cybersecurity Research and Experimental Development: The REVO Approach

    OpenAIRE

    Dan Craigen; Drew Vandeth; D’Arcy Walsh

    2013-01-01

    We present a systematic approach for managing a research and experimental development cybersecurity program that must be responsive to continuously evolving cybersecurity, and other, operational concerns. The approach will be of interest to research-program managers, academe, corporate leads, government leads, chief information officers, chief technology officers, and social and technology policy analysts. The approach is compatible with international standards and procedures published by the...

  18. HOW ADVERSE DRUG-REACTIONS CAN PLAY A ROLE IN INNOVATIVE DRUG RESEARCH - SIMILARITIES IN ADVERSE DRUG REACTION PROFILES OF CAPTOPRIL AND PENICILLAMINE

    NARCIS (Netherlands)

    RIKKEN, F; VOS, R

    1995-01-01

    We describe how adverse drug reactions (ADRs) can play an important role in pharmaceutical research and drug development. Not only do ADRs represent the risks and drawbacks associated with drugs but they can also be related to other knowledge available in pharmaceutical and medical research. We

  19. Drugs and Pregnancy: The Effects of Nonmedical Use of Drugs on Pregnancy, Childbirth, and Neonates. National Institute on Drug Abuse Research Issues 5.

    Science.gov (United States)

    Ferguson, Patricia, Ed.; And Others

    The National Institute on Drug Abuse presents this report as the fifth in a series intended to summarize the empirical research findings and major theoretical approaches relating to the the issues of drug use and abuse. Included in this volume are summaries of the major research findings concerning the effects of nonmedical drug use on pregnancy.…

  20. An experimental research on blended learning in the development ...

    African Journals Online (AJOL)

    The experimental research conducted for this study is based on a blended learning (BL) approach to the teaching of English as a Foreign Language (EFL) in China. The purpose of the study was to investigate the effectiveness of a blended learning approach aimed at improving students' listening and speaking skills.

  1. The Peter Effect in Early Experimental Education Research.

    Science.gov (United States)

    Little, Joseph

    2003-01-01

    Traces the ways in which educational researchers referred to Ronald A. Fisher's analysis of variance (ANOVA) between 1932 and 1944 in the "Journal of Experimental Education" (JXE). Shows how the changes in citational practices served to separate the ANOVA from its affiliation with Fisher, essentially effacing the memory of its human…

  2. Experimental forests and ranges : 100 years of research success stories

    Science.gov (United States)

    Gail Wells; Deborah Hayes; Katrina Krause; Ann Bartuska; Susan LeVan-Green; Jim Anderson; Tivoli Gough; Mary Adams; Thomas Schuler; Randy Kolka; Steve Sebestyen; Laura Kenefic; John Brissette; Susan Stout; Keith Kanoti; Fred Swanson; Sarah Greene; Margaret Herring; Martin Ritchie; Carl Skinner; Tom Lisle; Elizabeth Keppeler; Leslie Reid; Peter Wohlegemuth; Stanley Kitchen; Ward McCaughey; Jim Guldin; Don Bragg; Michael Shelton; David Loftis; Cathryn Greenberg; Julia Murphy

    2009-01-01

    In 2008, Forest Service Research and Development celebrated the Centennial Anniversary of these Experimental Forests and Ranges. This publication celebrates the many scientists who over the course of decades conducted the long-term studies that began and are continuing to shed light on important natural resource issues. Story suggestions were solicited from the...

  3. Overhead traveling crane vibration research using experimental wireless measuring system

    Directory of Open Access Journals (Sweden)

    Tomasz HANISZEWSKI

    2013-01-01

    Full Text Available The paper contains an operations and constructions description of theexperimental wireless measuring system for measuring accelerations in bridge cranes,based on PHIDGET 1056 sensors. Developed experimental research and measuringmethodology allows the use of the proposed wireless system on other cranesconstructions. The paper also shows examples of the results of vibration measurementsand FFT spectra, obtained on the basis of accelerations measurements.

  4. Nano-enabled drug delivery: a research profile.

    Science.gov (United States)

    Zhou, Xiao; Porter, Alan L; Robinson, Douglas K R; Shim, Min Suk; Guo, Ying

    2014-07-01

    Nano-enabled drug delivery (NEDD) systems are rapidly emerging as a key area for nanotechnology application. Understanding the status and developmental prospects of this area around the world is important to determine research priorities, and to evaluate and direct progress. Global research publication and patent databases provide a reservoir of information that can be tapped to provide intelligence for such needs. Here, we present a process to allow for extraction of NEDD-related information from these databases by involving topical experts. This process incorporates in-depth analysis of NEDD literature review papers to identify key subsystems and major topics. We then use these to structure global analysis of NEDD research topical trends and collaborative patterns, inform future innovation directions. This paper describes the process of how to derive nano-enabled drug delivery-related information from global research and patent databases in an effort to perform comprehensive global analysis of research trends and directions, along with collaborative patterns. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Drug research methodology. Volume 4, Epidemiology in drugs and highway safety : the study of drug use among drivers and its role in traffic crashes

    Science.gov (United States)

    1980-06-01

    This report presents the findings of a workshop on epidemiology in drugs and highway safety. A cross-disciplinary panel of experts (1) identified methodological issues and constraints present in research to define the nature and magnitude of the drug...

  6. Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice

    Directory of Open Access Journals (Sweden)

    PANCERA Christiane Finardi

    1997-01-01

    Full Text Available Mebendazole, albendazole, levamisole and thiabendazole are well known as active drugs against several nematode species, and against cestodes as well, when the first two drugs are considered. None of the drugs have proven activity, however, against trematodes. We tested the effect of these drugs on the fecal shedding of schistosome eggs and the recovering of adult schistosomes, after portal perfusion in Schistosoma mansoni experimentally infected mice. Balb/c mice infected with 80 S. mansoni cercariae were divided into three groups, each in turn subdivided into four other groups, for each tested drug. The first group was treated with each one of the studied drugs 25 days after S. mansoni infection; the second group was submitted to treatment with each one of the drugs 60 days after infection. Finally, the third group, considered as control, received no treatment. No effect upon fecal shedding of S. mansoni eggs and recovering of schistosomes after portal perfusion was observed when mice were treated with either mebendazole or albendazole. Mice treated with either levamisole or thiabendazole, on the other hand, showed a significant reduction in the recovering of adult schistosomes after portal perfusion, mainly when both drugs were given during the schistosomula evolution period, i.e., 25 days after cercariae penetration, probably due to unspecific immunomodulation

  7. Statistical Methodologies to Integrate Experimental and Computational Research

    Science.gov (United States)

    Parker, P. A.; Johnson, R. T.; Montgomery, D. C.

    2008-01-01

    Development of advanced algorithms for simulating engine flow paths requires the integration of fundamental experiments with the validation of enhanced mathematical models. In this paper, we provide an overview of statistical methods to strategically and efficiently conduct experiments and computational model refinement. Moreover, the integration of experimental and computational research efforts is emphasized. With a statistical engineering perspective, scientific and engineering expertise is combined with statistical sciences to gain deeper insights into experimental phenomenon and code development performance; supporting the overall research objectives. The particular statistical methods discussed are design of experiments, response surface methodology, and uncertainty analysis and planning. Their application is illustrated with a coaxial free jet experiment and a turbulence model refinement investigation. Our goal is to provide an overview, focusing on concepts rather than practice, to demonstrate the benefits of using statistical methods in research and development, thereby encouraging their broader and more systematic application.

  8. PBPK Modeling - A Predictive, Eco-Friendly, Bio-Waiver Tool for Drug Research.

    Science.gov (United States)

    De, Baishakhi; Bhandari, Koushik; Mukherjee, Ranjan; Katakam, Prakash; Adiki, Shanta K; Gundamaraju, Rohit; Mitra, Analava

    2017-01-01

    The world has witnessed growing complexities in disease scenario influenced by the drastic changes in host-pathogen- environment triadic relation. Pharmaceutical R&Ds are in constant search of novel therapeutic entities to hasten transition of drug molecules from lab bench to patient bedside. Extensive animal studies and human pharmacokinetics are still the "gold standard" in investigational new drug research and bio-equivalency studies. Apart from cost, time and ethical issues on animal experimentation, burning questions arise relating to ecological disturbances, environmental hazards and biodiversity issues. Grave concerns arises when the adverse outcomes of continued studies on one particular disease on environment gives rise to several other pathogenic agents finally complicating the total scenario. Thus Pharma R&Ds face a challenge to develop bio-waiver protocols. Lead optimization, drug candidate selection with favorable pharmacokinetics and pharmacodynamics, toxicity assessment are vital steps in drug development. Simulation tools like Gastro Plus™, PK Sim®, SimCyp find applications for the purpose. Advanced technologies like organ-on-a chip or human-on-a chip where a 3D representation of human organs and systems can mimic the related processes and activities, thereby linking them to major features of human biology can be successfully incorporated in the drug development tool box. PBPK provides the State of Art to serve as an optional of animal experimentation. PBPK models can successfully bypass bio-equivalency studies, predict bioavailability, drug interactions and on hyphenation with in vitro-in vivo correlation can be extrapolated to humans thus serving as bio-waiver. PBPK can serve as an eco-friendly bio-waiver predictive tool in drug development. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  9. Monitoring system for automation of experimental researches in cutting

    International Nuclear Information System (INIS)

    Kuzinovski, Mikolaj; Trajchevski, Neven; Filipovski, Velimir; Tomov, Mite; Cichosz, Piotr

    2009-01-01

    This study presents procedures being performed when projecting and realizing experimental scientific researches by application of the automated measurement system with a computer support in all experiment stages. A special accent is placed on the measurement system integration and mathematical processing of data from experiments. Automation processes are described through the realized own automated monitoring system for research of physical phenomena in the cutting process with computer-aided data acquisition. The monitoring system is intended for determining the tangential, axial and radial component of the cutting force, as well as average temperature in the cutting process. The hardware acquisition art consists of amplifiers and A/D converters, while as for analysis and visualization software for P C is developed by using M S Visual C++. For mathematical description researched physical phenomena CADEX software is made, which in connection with MATLAB is intended for projecting processing and analysis of experimental scientific researches against the theory for planning multi-factorial experiments. The design and construction of the interface and the computerized measurement system were done by the Faculty of Mechanical Engineering in Skopje in collaboration with the Faculty of Electrical Engineering and Information Technologies in Skopje and the Institute of Production Engineering and Automation, Wroclaw University of Technology, Poland. Gaining own scientific research measurement system with free access to hardware and software parts provides conditions for a complete control of the research process and reduction of interval of the measuring uncertainty of gained results from performed researches.

  10. Experimental methods and transport models for drug delivery across the blood-brain barrier.

    Science.gov (United States)

    Fu, Bingmei M

    2012-06-01

    The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the micro-environment of the brain. Although the special anatomical features of the BBB determine its protective role for the central nervous system (CNS) from blood-born neurotoxins, however, the BBB extremely limits the therapeutic efficacy of drugs into the CNS, which greatly hinders the treatment of major brain diseases. This review summarized the unique structures of the BBB, described a variety of in vivo and in vitro experimental methods for determining the transport properties of the BBB, e.g., the permeability of the BBB to water, ions, and solutes including nutrients, therapeutic agents and drug carriers, and presented newly developed mathematical models which quantitatively correlate the anatomical structures of the BBB with its barrier functions. Finally, on the basis of the experimental observations and the quantitative models, several strategies for drug delivery through the BBB were proposed.

  11. [Does the public sector have an independent research role in the development of drugs?].

    Science.gov (United States)

    Poulsen, Henrik Enghusen; Grønlykke, Thor Buch

    2003-04-14

    Exclusively private companies do drug development. The State contributes with education of academics and basic research constituting the basis of half of the drugs developed by the private companies. The Danish private drug research amounts to six billion DKK per year, corresponding to the estimated price of the development of one new drug. The development shows a negative tendency. There are doubts about the scientific credibility, the number of new drugs is declining, drug development costs are rising, and the competitiveness in Europe is declining compared with the one of The United States. Continued improvement of Danish drug development can be achieved by stimulation of the public research related to drug development.

  12. A Prospective Research on Self-medication Practices of Drug ...

    African Journals Online (AJOL)

    Preferred Customer

    METHODS: A multi-stage stratified sampling of drug retail outlets in Addis Ababa was employed. ... the drug. Two-thirds of the drug consumers requested drugs by specifically mentioning the name of the drug or category to which it belongs and 20.7% by telling their illness or .... city, and further classified as private, public.

  13. Intervention research in rational use of drugs : a review

    NARCIS (Netherlands)

    Le Grand, A; Van Hogerzeil, H; Haaijer-Ruskamp, FM; LeGrand, A.

    Many studies have been done to document drug use patterns, and indicate that overprescribing, multi-drug prescribing, misuse of drugs, use of unnecessary expensive drugs and overuse of antibiotics and injections are the most common problems of irrational drug use by prescribers as well as consumers.

  14. Experimental research of limits for thermal modulation transfer function

    Directory of Open Access Journals (Sweden)

    Tomić Ljubiša D.

    2009-01-01

    Full Text Available The paper presented testing of surface defects by pulse video thermography techniques. Such techniques rely on transient infrared radiation from the sample heated by the short duration flux initiated by flesh. Experimental measurements are realized by infrared sensor (FLIR camera. Testing results are considered for the samples with controlled designed defects beyond observed surfaces. The effects of response through the transparent wall are measured as infrared visible radiance. Researches with controlled samples are performed to verify visibility threshold of defect dimensions and forms, for possible use as modulation transfer function of defects hidden beyond the surfaces of thin metal walls. Dimensionless coefficients are derived for method estimations as the results from experimental research.

  15. Experimental Research on Vibrations of Double Harmonic Gear Transmission

    Directory of Open Access Journals (Sweden)

    Sava Ianici

    2017-11-01

    Full Text Available Gears transmission can be important sources of vibration in the mechanical system structures and can have a significant share in the overall vibration level. The current trend of significant increase in powers and speeds transmitted by modern mechanical systems, along with the size reduction, may cause a worsening of the behaviour of transmissions with gears in terms of vibration, especially when the optimization criteria were not respected in the design, execution and installation phase. This paper presents a study of vibrations that occur in a double harmonic gear transmission (DHGT, based on experimental research. The experimental researches revealed that in a double harmonic gear transmission the vibrations are initiated and develop in the multipara harmonics engagement of the teeth and in the kinematic couplings materialized between the wave generator and the flexible toothed wheel. These vibrations are later transmitted by means of the shafts and bearings to the transmission housing, respectively, through the walls of it, propagating in the air.

  16. Animal models of pancreatic cancer for drug research.

    Science.gov (United States)

    Kapischke, Matthias; Pries, Alexandra

    2008-10-01

    The operative and conservative results of therapy in pancreatic ductal adenocarcinoma remain appallingly poor. This underlines the demand for further research for effective anticancer drugs. The various animal models remain the essential method for the determination of efficacy of substances during preclinical phase. Unfortunately, most of these tested substances showed a good efficacy in pancreatic carcinoma in the animal model but were not confirmed during the clinical phase. The available literature in PubMed, Medline, Ovid and secondary literature was searched regarding the available animal models for drug testing against pancreatic cancer. The models were analyzed regarding their pros and cons in anticancer drug testing. The different modifications of the orthotopic model (especially in mice) seem at present to be the best model for anticancer testing in pancreatic carcinoma. The value of genetically engineered animal model (GEM) and syngeneic models is on debate. A good selection of the model concerning the questions supposed to be clarified may improve the comparability of the results of animal experiments compared to clinical trials.

  17. The visualization and availability of experimental research data at Elsevier

    Science.gov (United States)

    Keall, Bethan

    2014-05-01

    In the digital age, the visualization and availability of experimental research data is an increasingly prominent aspect of the research process and of the scientific output that researchers generate. We expect that the importance of data will continue to grow, driven by technological advancements, requirements from funding bodies to make research data available, and a developing research data infrastructure that is supported by data repositories, science publishers, and other stakeholders. Elsevier is actively contributing to these efforts, for example by setting up bidirectional links between online articles on ScienceDirect and relevant data sets on trusted data repositories. A key aspect of Elsevier's "Article of the Future" program, these links enrich the online article and make it easier for researchers to find relevant data and articles and help place data in the right context for re-use. Recently, we have set up such links with some of the leading data repositories in Earth Sciences, including the British Geological Survey, Integrated Earth Data Applications, the UK Natural Environment Research Council, and the Oak Ridge National Laboratory DAAC. Building on these links, Elsevier has also developed a number of data integration and visualization tools, such as an interactive map viewer that displays the locations of relevant data from PANGAEA next to articles on ScienceDirect. In this presentation we will give an overview of these and other capabilities of the Article of the Future, focusing on how they help advance communication of research in the digital age.

  18. Ebola virus: A gap in drug design and discovery - experimental and computational perspective.

    Science.gov (United States)

    Balmith, Marissa; Faya, Mbuso; Soliman, Mahmoud E S

    2017-03-01

    The Ebola virus, formally known as the Ebola hemorrhagic fever, is an acute viral syndrome causing sporadic outbreaks that have ravaged West Africa. Due to its extreme virulence and highly transmissible nature, Ebola has been classified as a category A bioweapon organism. Only recently have vaccine or drug regimens for the Ebola virus been developed, including Zmapp and peptides. In addition, existing drugs which have been repurposed toward anti-Ebola virus activity have been re-examined and are seen to be promising candidates toward combating Ebola. Drug development involving computational tools has been widely employed toward target-based drug design. Screening large libraries have greatly stimulated research toward effective anti-Ebola virus drug regimens. Current emphasis has been placed on the investigation of host proteins and druggable viral targets. There is a huge gap in the literature regarding guidelines in the discovery of Ebola virus inhibitors, which may be due to the lack of information on the Ebola drug targets, binding sites, and mechanism of action of the virus. This review focuses on Ebola virus inhibitors, drugs which could be repurposed to combat the Ebola virus, computational methods which study drug-target interactions as well as providing further insight into the mode of action of the Ebola virus. © 2016 John Wiley & Sons A/S.

  19. Analyzing research trends on drug safety using topic modeling.

    Science.gov (United States)

    Zou, Chen

    2018-04-06

    Published drug safety data has evolved in the past decade due to scientific and technological advances in the relevant research fields. Considering that a vast amount of scientific literature has been published in this area, it is not easy to identify the key information. Topic modeling has emerged as a powerful tool to extract meaningful information from a large volume of unstructured texts. Areas covered: We analyzed the titles and abstracts of 4347 articles in four journals dedicated to drug safety from 2007 to 2016. We applied Latent Dirichlet allocation (LDA) model to extract 50 main topics, and conducted trend analysis to explore the temporal popularity of these topics over years. Expert Opinion/Commentary: We found that 'benefit-risk assessment and communication', 'diabetes' and 'biologic therapy for autoimmune diseases' are the top 3 most published topics. The topics relevant to the use of electronic health records/observational data for safety surveillance are becoming increasingly popular over time. Meanwhile, there is a slight decrease in research on signal detection based on spontaneous reporting, although spontaneous reporting still plays an important role in benefit-risk assessment. The topics related to medical conditions and treatment showed highly dynamic patterns over time.

  20. The Research Progress of Targeted Drug Delivery Systems

    Science.gov (United States)

    Zhan, Jiayin; Ting, Xizi Liang; Zhu, Junjie

    2017-06-01

    Targeted drug delivery system (DDS) means to selectively transport drugs to targeted tissues, organs, and cells through a variety of drugs carrier. It is usually designed to improve the pharmacological and therapeutic properties of conventional drugs and to overcome problems such as limited solubility, drug aggregation, poor bio distribution and lack of selectivity, controlling drug release carrier and to reduce normal tissue damage. With the characteristics of nontoxic and biodegradable, it can increase the retention of drug in lesion site and the permeability, improve the concentration of the drug in lesion site. at present, there are some kinds of DDS using at test phase, such as slow controlled release drug delivery system, targeted drug delivery systems, transdermal drug delivery system, adhesion dosing system and so on. This paper makes a review for DDS.

  1. Evaluating the ergonomics of BCI devices for research and experimentation.

    Science.gov (United States)

    Ekandem, Joshua I; Davis, Timothy A; Alvarez, Ignacio; James, Melva T; Gilbert, Juan E

    2012-01-01

    The use of brain computer interface (BCI) devices in research and applications has exploded in recent years. Applications such as lie detectors that use functional magnetic resonance imaging (fMRI) to video games controlled using electroencephalography (EEG) are currently in use. These developments, coupled with the emergence of inexpensive commercial BCI headsets, such as the Emotiv EPOC ( http://emotiv.com/index.php ) and the Neurosky MindWave, have also highlighted the need of performing basic ergonomics research since such devices have usability issues, such as comfort during prolonged use, and reduced performance for individuals with common physical attributes, such as long or coarse hair. This paper examines the feasibility of using consumer BCIs in scientific research. In particular, we compare user comfort, experiment preparation time, signal reliability and ease of use in light of individual differences among subjects for two commercially available hardware devices, the Emotiv EPOC and the Neurosky MindWave. Based on these results, we suggest some basic considerations for selecting a commercial BCI for research and experimentation. STATEMENT OF RELEVANCE: Despite increased usage, few studies have examined the usability of commercial BCI hardware. This study assesses usability and experimentation factors of two commercial BCI models, for the purpose of creating basic guidelines for increased usability. Finding that more sensors can be less comfortable and accurate than devices with fewer sensors.

  2. Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers.

    Science.gov (United States)

    Duka, Theodora; Crombag, Hans S; Stephens, David N

    2011-09-01

    Several theoretical frameworks have been developed to understand putative processes and mechanisms involved in addiction. Whilst these 'theories of addiction' disagree about importance and/or nature of a number of key psychological processes (e.g. the necessity of craving and/or the involvement of drug-value representations), a number of commonalities exist. For instance, it is widely accepted that Pavlovian associations between cues and environmental contexts and the drug effects acquired over the course of addiction play a critical role, especially in relapse vulnerability in detoxified addicts. Additionally, all theories of addiction (explicitly or implicitly) propose that chronic drug exposure produces persistent neuroplastic changes in neurobiological circuitries underlying critical emotional, cognitive and motivational processes, although disagreement exists as to the precise nature of these neurobiological changes and/or their psychological consequences. The present review, rather than limiting itself to any particular theoretical stance, considers various candidate psychological, neurobiological and/or behavioral processes in addiction and outlines conceptual and procedural approaches for the experimental medicine laboratory. The review discusses (1) extinction, renewal and (re)consolidation of learned associations between cues and drugs, (2) the drug reward value, (3) motivational states contributing to drug seeking and (4) reflective (top-down) and sensory (bottom-up) driven decision-making. In evaluating these psychological and/or behavioral processes and their relationship to addiction we make reference to putative underlying brain structures identified by basic animal studies and/or imaging studies with humans.

  3. Changing children's eating behaviour - A review of experimental research.

    Science.gov (United States)

    DeCosta, Patricia; Møller, Per; Frøst, Michael Bom; Olsen, Annemarie

    2017-06-01

    The interest in children's eating behaviours and how to change them has been growing in recent years. This review examines the following questions: What strategies have been used to change children's eating behaviours? Have their effects been experimentally demonstrated? And, are the effects transient or enduring? Medline and Cab abstract (Ovid) and Web of Science (Thomson Reuters) were used to identify the experimental studies. A total of 120 experimental studies were identified and they are presented grouped within these 11 topics; parental control, reward, social facilitation, cooking programs, school gardens, sensory education, availability and accessibility, choice architecture and nudging, branding and food packaging, preparation and serving style, and offering a choice. In conclusion, controlling strategies for changing children's eating behaviour in a positive direction appear to be counterproductive. Hands-on approaches such as gardening and cooking programs may encourage greater vegetable consumption and may have a larger effect compared to nutrition education. Providing children with free, accessible fruits and vegetables have been experimentally shown to positively affect long-term eating behaviour. The authors recommend future research to examine how taste and palatability can positively affect children's attitudes and eating behaviour. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

    Institute of Scientific and Technical Information of China (English)

    Rita Diehl; Fabienne Ferrara; Claudia Müller; Antje Y Dreyer; Damian D McLeod; Stephan Fricke; Johannes Boltze

    2017-01-01

    Almost every experimental treatment strategy using non-autologous cell,tissue or organ transplantation is tested in small and large animal models before clinical translation.Because these strategies require immunosuppression in most cases,immunosuppressive protocols are a key element in transplantation experiments.However,standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species.Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation.This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects.It also summarizes contemporary knowledge of novel immunomodulatory strategies,such as the use of mesenchymal stem cells or antibodies.Thus,this review is intended to serve as a state-of-the-art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.

  5. Research synergy and drug development: Bright stars in neighboring constellations

    Directory of Open Access Journals (Sweden)

    Samet Keserci

    2017-11-01

    Full Text Available Drug discovery and subsequent availability of a new breakthrough therapeutic or ‘cure’ is a compelling example of societal benefit from research advances. These advances are invariably collaborative, involving the contributions of many scientists to a discovery network in which theory and experiment are built upon. To document and understand such scientific advances, data mining of public and commercial data sources coupled with network analysis can be used as a digital methodology to assemble and analyze component events in the history of a therapeutic. This methodology is extensible beyond the history of therapeutics and its use more generally supports (i efficiency in exploring the scientific history of a research advance (ii documenting and understanding collaboration (iii portfolio analysis, planning and optimization (iv communication of the societal value of research. Building upon prior art, we have conducted a case study of five anti-cancer therapeutics to identify the collaborations that resulted in the successful development of these therapeutics both within and across their respective networks. We have linked the work of over 235,000 authors in roughly 106,000 scientific publications that capture the research crucial for the development of these five therapeutics. Applying retrospective citation discovery, we have identified a core set of publications cited in the networks of all five therapeutics and additional intersections in combinations of networks. We have enriched the content of these networks by annotating them with information on research awards from the US National Institutes of Health (NIH. Lastly, we have mapped these awards to their cognate peer review panels, identifying another layer of collaborative scientific activity that influenced the research represented in these networks. Keywords: Information science, Cancer research

  6. Automation of experimental research of waveguide paths induction soldering

    Science.gov (United States)

    Tynchenko, V. S.; Petrenko, V. E.; Kukartsev, V. V.; Tynchenko, V. V.; Antamoshkin, O. A.

    2018-05-01

    The article presents an automated system of experimental studies of the waveguide paths induction soldering process. The system is a part of additional software for a complex of automated control of the technological process of induction soldering of thin-walled waveguide paths from aluminum alloys, expanding its capabilities. The structure of the software product, the general appearance of the controls and the potential application possibilities are presented. The utility of the developed application by approbation in a series of field experiments was considered and justified. The application of the experimental research system makes it possible to improve the process under consideration, providing the possibility of fine-tuning the control regulators, as well as keeping the statistics of the soldering process in a convenient form for analysis.

  7. Experimental nuclear physics research challenges at low energies

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, E.; Morales G, L. [UNAM, Instituto de Fisica, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Murillo O, G. [ININ, Carretera Mexico-Toluca s/n, Ocoyoacac 52750, Estado de Mexico (Mexico)

    2010-02-15

    Experimental research with low energy beams of ions (a few MeV) in nuclear physics has gone through a phase transition along its evolution in fifty years because of the increasing complexity (and cost) of the equipment required to conduct meaningful investigations. Many of the small cyclotrons and Van de Graaff (single ended and tandem) accelerators have been used for the last three decades mostly in applications related to the characterization and modification of materials. Specific experimental investigations in nuclear physics with low energy accelerators are proposed in this work. Specifically we discuss the topic of nuclear radii measurements of radioactive species produced via (d,n) reactions. Some emphasis is given to the instrumentation required. (Author)

  8. Experimental research on pressurized water reactor(PWR) safety

    International Nuclear Information System (INIS)

    Kim, Dong Su; Chae, Sung Ki; Chang, Won Pyo

    1991-12-01

    The objective of this research is to analyze the experimental results already performed in BETHSY facility of CEA France and to establish essential technologies for the future implementation of both such an experiment and computer code assessment, which are not undergoing in Korea so far. The contents of the present study are divided into 2 categories; namely, analysis of the BETHSY experimental data received from CEA, and CATHARE computer code simulation for the selected experiments, i.e. 'Natural Circulation(Test 4.3a)' and '2 Cold Leg Break'. The later studies are performed under the aims of CATHARE assessment as well as qualification of KOSAC code developing at KAERI, which is the subject in the next year and will concern an adequacy of KOSAC for the prediction of low flow natural circulation and a small break transients. (Author)

  9. Research on drug abuse and addiction treatment in prisons

    OpenAIRE

    Kljajević Srđan

    2017-01-01

    The causes of drug abuse and criminal behavior are closely linked. Not surprisingly, there is a high percentage of prisoners who during sentence execution abuse or are dependent on drugs. Antisocial personality disorder can be considered a common predictor of committing criminal offenses and drug abuse. A review of studies has revealed a high prevalence of inmates who use drugs while serving a sentence. Also, prison environment represents only a new context of the continuum of drug abuse by i...

  10. Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

    OpenAIRE

    Baranowski, Przemysław; Karolewicz, Bożena; Gajda, Maciej; Pluta, Janusz

    2014-01-01

    This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to...

  11. Experimental research on safety assurance of advanced WWER fuel cycles

    International Nuclear Information System (INIS)

    Krainov, Ju.; Kukushkin, Ju.

    2002-01-01

    The paper presents the results of experimental investigations on substantiation of implementation of a modernized butt joint for the WWER-440 reactor, carried out in the critical test facility 'P' in the RRC 'Kurchatov Institute'. The comparison results of the calculation and experimental data obtained in the physical startup of Volgodonsk NPP-1 with the WWER-1000 are also given. In the implementation of four-year fuel cycle in the WWER-440 with the average enrichment of fuel makeup 3.82% it was solved to conduct experimental research of power distribution in the vicinity of control rod butt junction. Moreover, it was assumed that adequate actions should be applied to eliminate inadmissible power jumps, if necessary. It is not available to measure their values in NPP conditions. Therefore, the power distribution near the butt joint was studied in a 19-rod bank installed in the critical test facility 'P' first for the normal design of the joint when surrounding fuel assemblies enrichment goes up. Then a set of calculation and tests was fulfilled to optimize a butt junction design. On the base of this research the composition of a butt junction was advanced by placing Hf plates into the junction. The effectiveness of modernized butt joint design was experimentally confirmed. In Volgodonsk NPP-1 with WWER-1000 the four-year fuel cycle is being implemented. During the physical startup of the reactor the measurements of the reactivity effects and coefficients were measured at the minimum controlled flux level, and the parameters of a number of critical states were recorded. The data obtained were compared with the calculation. The validity of the certified code package for forecasting the neutronic characteristics of WWER-1000 cores in the implementation of a four year fuel cycle has been supported (Authors)

  12. Managing Cybersecurity Research and Experimental Development: The REVO Approach

    Directory of Open Access Journals (Sweden)

    Dan Craigen

    2013-07-01

    Full Text Available We present a systematic approach for managing a research and experimental development cybersecurity program that must be responsive to continuously evolving cybersecurity, and other, operational concerns. The approach will be of interest to research-program managers, academe, corporate leads, government leads, chief information officers, chief technology officers, and social and technology policy analysts. The approach is compatible with international standards and procedures published by the Organisation for Economic Co-operation and Development (OECD and the Treasury Board of Canada Secretariat (TBS. The key benefits of the approach are the following: i the breadth of the overall (cybersecurity space is described; ii depth statements about specific (cybersecurity challenges are articulated and mapped to the breadth of the problem; iii specific (cybersecurity initiatives that have been resourced through funding or personnel are tracked and linked to specific challenges; and iv progress is assessed through key performance indicators. Although we present examples from cybersecurity, the method may be transferred to other domains. We have found the approach to be rigorous yet adaptive to change; it challenges an organization to be explicit about the nature of its research and experimental development in a manner that fosters alignment with evolving business priorities, knowledge transfer, and partner engagement.

  13. Research synergy and drug development: Bright stars in neighboring constellations.

    Science.gov (United States)

    Keserci, Samet; Livingston, Eric; Wan, Lingtian; Pico, Alexander R; Chacko, George

    2017-11-01

    Drug discovery and subsequent availability of a new breakthrough therapeutic or 'cure' is a compelling example of societal benefit from research advances. These advances are invariably collaborative, involving the contributions of many scientists to a discovery network in which theory and experiment are built upon. To document and understand such scientific advances, data mining of public and commercial data sources coupled with network analysis can be used as a digital methodology to assemble and analyze component events in the history of a therapeutic. This methodology is extensible beyond the history of therapeutics and its use more generally supports (i) efficiency in exploring the scientific history of a research advance (ii) documenting and understanding collaboration (iii) portfolio analysis, planning and optimization (iv) communication of the societal value of research. Building upon prior art, we have conducted a case study of five anti-cancer therapeutics to identify the collaborations that resulted in the successful development of these therapeutics both within and across their respective networks. We have linked the work of over 235,000 authors in roughly 106,000 scientific publications that capture the research crucial for the development of these five therapeutics. Applying retrospective citation discovery, we have identified a core set of publications cited in the networks of all five therapeutics and additional intersections in combinations of networks. We have enriched the content of these networks by annotating them with information on research awards from the US National Institutes of Health (NIH). Lastly, we have mapped these awards to their cognate peer review panels, identifying another layer of collaborative scientific activity that influenced the research represented in these networks.

  14. Interdisciplinary researches for potential developments of drugs and natural products

    Directory of Open Access Journals (Sweden)

    Arunrat Chaveerach

    2017-04-01

    Full Text Available Developments of drugs or natural products from plants are possibly made, simple to use and lower cost than modern drugs. The development processes can be started with studying local wisdom and literature reviews to choose the plants which have long been used in diverse areas, such as foods, traditional medicine, fragrances and seasonings. Then those data will be associated with scientific researches, namely plant collection and identification, phytochemical screening by gas chromatography-mass spectrometry, pharmacological study/review for their functions, and finally safety and efficiency tests in human. For safety testing, in vitro cell toxicity by cell viability assessment and in vitro testing of DNA breaks by the comet assay in human peripheral blood mononuclear cells can be performed. When active chemicals and functions containing plants were chosen with safety and efficacy for human uses, then, the potential medicinal natural products will be produced. Based on these procedures, the producing cost will be cheaper and the products can be evaluated for their clinical properties. Thus, the best and lowest-priced medicines and natural products can be distributed worldwide.

  15. Interdisciplinary researches for potential developments of drugs and natural products

    Institute of Scientific and Technical Information of China (English)

    Arunrat Chaveerach; Runglawan Sudmoon; Tawatchai Tanee

    2017-01-01

    Developments of drugs or natural products from plants are possibly made,simple to use and lower cost than modern drugs.The development processes can be started with studying local wisdom and literature reviews to choose the plants which have long been used in diverse areas,such as foods,traditional medicine,fragrances and seasonings.Then those data will be associated with scientific researches,namely plant collection and identification,phytochemical screening by gas chromatography-mass spectrometry,pharmacological study/review for their functions,and finally safety and efficiency tests in human.For safety testing,in vitro cell toxicity by cell viability assessment and in vitro testing of DNA breaks by the comet assay in human peripheral blood mononuclear cells can be performed.When active chemicals and functions containing plants were chosen with safety and efficacy for human uses,then,the potential medicinal natural products will be produced.Based on these procedures,the producing cost will be cheaper and the products can be evaluated for their clinical properties.Thus,the best and lowest-priced medicines and natural products can be distributed worldwide.

  16. Wind conditions in urban layout - Numerical and experimental research

    Science.gov (United States)

    Poćwierz, Marta; Zielonko-Jung, Katarzyna

    2018-01-01

    This paper presents research which compares the numerical and the experimental results for different cases of airflow around a few urban layouts. The study is concerned mostly with the analysis of parameters, such as pressure and velocity fields, which are essential in the building industry. Numerical simulations have been performed by the commercial software Fluent, with the use of a few different turbulence models, including popular k-ɛ, k-ɛ realizable or k-ω. A particular attention has been paid to accurate description of the conditions on the inlet and the selection of suitable computing grid. The pressure measurement near buildings and oil visualization were undertaken and described accordingly.

  17. TIBER: Tokamak Ignition/Burn Experimental Research. Final design report

    International Nuclear Information System (INIS)

    Henning, C.D.; Logan, B.G.; Barr, W.L.

    1985-01-01

    The Tokamak Ignition/Burn Experimental Research (TIBER) device is the smallest superconductivity tokamak designed to date. In the design plasma shaping is used to achieve a high plasma beta. Neutron shielding is minimized to achieve the desired small device size, but the superconducting magnets must be shielded sufficiently to reduce the neutron heat load and the gamma-ray dose to various components of the device. Specifications of the plasma-shaping coil, the shielding, coaling, requirements, and heating modes are given. 61 refs., 92 figs., 30 tabs

  18. Research reactor RB, technical characteristics and experimental possibilities

    International Nuclear Information System (INIS)

    Sotic, O.; Vranic, S.

    1978-01-01

    Nuclear research reactor RB tn the Nuclear Engineering Laboratory at the Institute of Nuclear Sciences 'Boris Kidric' in Vinca is the first reactor system built in Yugoslavia in 1958. In this report, the basic technical characteristics of this reactor are described, as well as the experimental possibilities it offers to the users. Its relatively simple construction and flexibility enables direct measurements of a series of physical parameters, and the absence of the biological protection shield makes it very useful for Various biological and other irradiations and dosimetric measurements Where strong neutron source is required. (author) [sr

  19. Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

    Directory of Open Access Journals (Sweden)

    Przemysław Baranowski

    2014-01-01

    Full Text Available This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments, in situ gels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommended in vitro and in vivo studies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient’s compliance.

  20. Annual tendency of research papers used ICR mice as experimental animals in biomedical research fields

    OpenAIRE

    Kim, Ji Eun; Nam, Jung Hoon; Cho, Joon Young; Kim, Kil Soo; Hwang, Dae Youn

    2017-01-01

    Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agricultur...

  1. Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors.

    Directory of Open Access Journals (Sweden)

    Anna Cichonska

    2017-08-01

    Full Text Available Due to relatively high costs and labor required for experimental profiling of the full target space of chemical compounds, various machine learning models have been proposed as cost-effective means to advance this process in terms of predicting the most potent compound-target interactions for subsequent verification. However, most of the model predictions lack direct experimental validation in the laboratory, making their practical benefits for drug discovery or repurposing applications largely unknown. Here, we therefore introduce and carefully test a systematic computational-experimental framework for the prediction and pre-clinical verification of drug-target interactions using a well-established kernel-based regression algorithm as the prediction model. To evaluate its performance, we first predicted unmeasured binding affinities in a large-scale kinase inhibitor profiling study, and then experimentally tested 100 compound-kinase pairs. The relatively high correlation of 0.77 (p < 0.0001 between the predicted and measured bioactivities supports the potential of the model for filling the experimental gaps in existing compound-target interaction maps. Further, we subjected the model to a more challenging task of predicting target interactions for such a new candidate drug compound that lacks prior binding profile information. As a specific case study, we used tivozanib, an investigational VEGF receptor inhibitor with currently unknown off-target profile. Among 7 kinases with high predicted affinity, we experimentally validated 4 new off-targets of tivozanib, namely the Src-family kinases FRK and FYN A, the non-receptor tyrosine kinase ABL1, and the serine/threonine kinase SLK. Our sub-sequent experimental validation protocol effectively avoids any possible information leakage between the training and validation data, and therefore enables rigorous model validation for practical applications. These results demonstrate that the kernel

  2. Experimental investigation on blood magnetic contamination in the presence of drug molecules

    International Nuclear Information System (INIS)

    Creanga, D E; Nadejde, C; Iacob, G H

    2009-01-01

    The purpose of the present project was to study the interference of magnetic nanoparticles with drug molecules - rifampicin, used in lung infectious disease and respectively, sodium diclofenac, an antiinflammatory steroid. The controlled magnetic contamination was accomplished using colloidal nanoparticles supplied from diluted magnetic fluids. Various concentrations of diluted aqueous magnetic fluids, based on magnetite cores coated with citric acid and respectively sodium oleate, were tested. The experiment was focused on the capacity of the magnetic nanoparticles to form reversible complexes with the drug molecules, as well as on the monitoring of the nanoparticle-drug complex dynamics, under the action of external magnetic field. The level of released rifampicin ranged between 4 mg/100 ml and 7 mg/100 ml for the magnetic exposure of 20 mT, while the sodium diclofenac decomplexation level was not higher than 2.5 mg/100 ml under magnetic exposure of 60 mT. The experimental arrangement was proved to be an adequate model for the dynamical study of magnetite reversible complexation with drug molecules, evidencing certain specific values of drug concentration and magnetic field induction that favour such interactions.

  3. Experimental investigation on blood magnetic contamination in the presence of drug molecules

    Energy Technology Data Exchange (ETDEWEB)

    Creanga, D E; Nadejde, C [' Al. I. Cuza' University, Faculty of Physics, 11A Blvd. Carol I, RO-700506, Iasi (Romania); Iacob, G H [' Gr. T. Popa' University, Faculty of Biomedical Engineering, Kogalniceanu Street, No. 9-13, RO-700454, Iasi (Romania)], E-mail: nadej_dia@yahoo.com

    2009-05-01

    The purpose of the present project was to study the interference of magnetic nanoparticles with drug molecules - rifampicin, used in lung infectious disease and respectively, sodium diclofenac, an antiinflammatory steroid. The controlled magnetic contamination was accomplished using colloidal nanoparticles supplied from diluted magnetic fluids. Various concentrations of diluted aqueous magnetic fluids, based on magnetite cores coated with citric acid and respectively sodium oleate, were tested. The experiment was focused on the capacity of the magnetic nanoparticles to form reversible complexes with the drug molecules, as well as on the monitoring of the nanoparticle-drug complex dynamics, under the action of external magnetic field. The level of released rifampicin ranged between 4 mg/100 ml and 7 mg/100 ml for the magnetic exposure of 20 mT, while the sodium diclofenac decomplexation level was not higher than 2.5 mg/100 ml under magnetic exposure of 60 mT. The experimental arrangement was proved to be an adequate model for the dynamical study of magnetite reversible complexation with drug molecules, evidencing certain specific values of drug concentration and magnetic field induction that favour such interactions.

  4. Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs.

    Science.gov (United States)

    Rastrojo, Alberto; García-Hernández, Raquel; Vargas, Paola; Camacho, Esther; Corvo, Laura; Imamura, Hideo; Dujardin, Jean-Claude; Castanys, Santiago; Aguado, Begoña; Gamarro, Francisco; Requena, Jose M

    2018-04-13

    Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures. No vaccines exist for human use, and the chemotherapeutic agents currently used are scanty. Furthermore, for some drugs, resistance and treatment failure are increasing to alarming levels. The aim of this work was to identify genomic and trancriptomic alterations associated with experimental resistance against the common drugs used against VL: trivalent antimony (Sb III , S line), amphotericin B (AmB, A line), miltefosine (MIL, M line) and paromomycin (PMM, P line). A total of 1006 differentially expressed transcripts were identified in the S line, 379 in the A line, 146 in the M line, and 129 in the P line. Also, changes in ploidy of chromosomes and amplification/deletion of particular regions were observed in the resistant lines regarding the parental one. A series of genes were identified as possible drivers of the resistance phenotype and were validated in both promastigotes and amastigotes from Leishmania donovani, Leishmania infantum and Leishmania major species. Remarkably, a deletion of the gene LinJ.36.2510 (coding for 24-sterol methyltransferase, SMT) was found to be associated with AmB-resistance in the A line. In the P line, a dramatic overexpression of the transcripts LinJ.27.T1940 and LinJ.27.T1950 that results from a massive amplification of the collinear genes was suggested as one of the mechanisms of PMM resistance. This conclusion was reinforced after transfection experiments in which significant PMM-resistance was generated in WT parasites over-expressing either gene LinJ.27.1940 (coding for a D-lactate dehydrogenase-like protein, D-LDH) or gene LinJ.27.1950 (coding for an aminotransferase of branched-chain amino acids, BCAT). This work allowed to identify new drivers, like SMT, the deletion of which being associated with resistance to AmB, and the tandem D

  5. Experimental research on crossing shock wave boundary layer interactions

    Science.gov (United States)

    Settles, G. S.; Garrison, T. J.

    1994-10-01

    An experimental research effort of the Penn State Gas Dynamics Laboratory on the subject of crossing shock wave boundary layer interactions is reported. This three year study was supported by AFOSR Grant 89-0315. A variety of experimental techniques were employed to study the above phenomena including planar laser scattering flowfield visualization, kerosene lampblack surface flow visualization, laser-interferometer skin friction surveys, wall static pressure measurements, and flowfield five-hole probe surveys. For a model configuration producing two intersecting shock waves, measurements were made for a range of oblique shock strengths at freestream Mach numbers of 3.0 and 3.85. Additionally, measurements were made at Mach 3.85 for a configuration producing three intersecting waves. The combined experimental dataset was used to formulate the first detailed flowfield models of the crossing-shock and triple-shock wave/boundary layer interactions. The structure of these interactions was found to be similar over a broad range of interaction strengths and is dominated by a large, separated, viscous flow region.

  6. Experimental Research Using of MQL in Metal Cutting

    Directory of Open Access Journals (Sweden)

    G. Globočki Lakić

    2013-12-01

    Full Text Available In this paper an effect of using of minimal quantity lubrication (MQL technique in turning operations is presented. Experimental research was performed on carbon steel C45E. Technological parameters: depth of cut, feed rate and cutting speed were adjusted to semi-machining and roughing. Higher values ​​of feed and cutting speed were used, than recommended from literature and different types of cooling and lubrication in turning conditions were applied. As a conventional procedure and technology, lubrication with flooding was applied. As special lubrication the MQL technique was used. During research, monitoring of the cutting force, chip shape, tool wear and surface roughness was performed. Relations between parameters, material machinability and economy of process were analyzed.

  7. Theoretical & Experimental Research in Weak, Electromagnetic & Strong Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Nandi, Satyanarayan [Oklahoma State Univ., Stillwater, OK (United States); Babu, Kaladi [Oklahoma State Univ., Stillwater, OK (United States); Rizatdinova, Flera [Oklahoma State Univ., Stillwater, OK (United States); Khanov, Alexander [Oklahoma State Univ., Stillwater, OK (United States); Haley, Joseph [Oklahoma State Univ., Stillwater, OK (United States)

    2015-09-17

    The conducted research spans a wide range of topics in the theoretical, experimental and phenomenological aspects of elementary particle interactions. Theory projects involve topics in both the energy frontier and the intensity frontier. The experimental research involves energy frontier with the ATLAS Collaboration at the Large Hadron Collider (LHC). In theoretical research, novel ideas going beyond the Standard Model with strong theoretical motivations were proposed, and their experimental tests at the LHC and forthcoming neutrino facilities were outlined. These efforts fall into the following broad categories: (i) TeV scale new physics models for LHC Run 2, including left-right symmetry and trinification symmetry, (ii) unification of elementary particles and forces, including the unification of gauge and Yukawa interactions, (iii) supersummetry and mechanisms of supersymmetry breaking, (iv) superworld without supersymmetry, (v) general models of extra dimensions, (vi) comparing signals of extra dimensions with those of supersymmetry, (vii) models with mirror quarks and mirror leptons at the TeV scale, (viii) models with singlet quarks and singlet Higgs and their implications for Higgs physics at the LHC, (ix) new models for the dark matter of the universe, (x) lepton flavor violation in Higgs decays, (xi) leptogenesis in radiative models of neutrino masses, (xii) light mediator models of non-standard neutrino interactions, (xiii) anomalous muon decay and short baseline neutrino anomalies, (xiv) baryogenesis linked to nucleon decay, and (xv) a new model for recently observed diboson resonance at the LHC and its other phenomenological implications. The experimental High Energy Physics group has been, and continues to be, a successful and productive contributor to the ATLAS experiment at the LHC. Members of the group performed search for gluinos decaying to stop and top quarks, new heavy gauge bosons decaying to top and bottom quarks, and vector-like quarks

  8. About soil cover heterogeneity of agricultural research stations' experimental fields

    Science.gov (United States)

    Rannik, Kaire; Kõlli, Raimo; Kukk, Liia

    2013-04-01

    Depending on local pedo-ecological conditions (topography, (geo) diversity of soil parent material, meteorological conditions) the patterns of soil cover and plant cover determined by soils are very diverse. Formed in the course of soil-plant mutual relationship, the natural ecosystems are always influenced to certain extent by the other local soil forming conditions or they are site specific. The agricultural land use or the formation of agro-ecosystems depends foremost on the suitability of soils for the cultivation of feed and food crops. As a rule, the most fertile or the best soils of the area, which do not present any or present as little as possible constraints for agricultural land use, are selected for this purpose. Compared with conventional field soils, the requirements for the experimental fields' soil cover quality are much higher. Experimental area soils and soil cover composition should correspond to local pedo-ecological conditions and, in addition to that, represent the soil types dominating in the region, whereas the fields should be as homogeneous as possible. The soil cover heterogeneity of seven arable land blocks of three research stations (Jõgeva, Kuusiku and Olustvere) was studied 1) by examining the large scale (1:10 000) digital soil map (available via the internet), and 2) by field researches using the transect method. The stages of soils litho-genetic and moisture heterogeneities were estimated by using the Estonian normal soils matrix, however, the heterogeneity of top- and subsoil texture by using the soil texture matrix. The quality and variability of experimental fields' soils humus status, was studied more thoroughly from the aspect of humus concentration (g kg-1), humus cover thickness (cm) and humus stocks (Mg ha-1). The soil cover of Jõgeva experimental area, which presents an accumulative drumlin landscape (formed during the last glacial period), consist from loamy Luvisols and associated to this Cambisols. In Kuusiku area

  9. On Coba and Cocok: youth-led drug-experimentation in Eastern Indonesia

    NARCIS (Netherlands)

    Hardon, A.; Idrus, N.I.

    2014-01-01

    The everyday lives of contemporary youths are awash with drugs to boost pleasure, moods, sexual performance, vitality, appearance and health. This paper examines pervasive practices of chemical ‘self-maximization’ from the perspectives of youths themselves. The research for this paper was conducted

  10. Contributions of experimental psychiatry to research on the psychosis prodrome

    Directory of Open Access Journals (Sweden)

    Mitja eBodatsch

    2013-12-01

    Full Text Available In the recent decades, a paradigmatic change in psychosis research and treatment shifted attention towards the early and particularly the prodromal stages of illness. Despite substantial progress with regard to the neuronal underpinnings of psychosis development, the crucial biological mechanisms leading to manifest illness are yet insufficiently understood. Until today, one significant approach to elucidate the neurobiology of psychosis has been the modeling of psychotic symptoms by psychedelic substances in healthy individuals. These models bear the opportunity to evoke particular neuronal aberrations and the respective psychotic symptoms in a controlled experimental setting. In the present paper, we hypothesize that experimental psychiatry bears unique opportunities in elucidating the biological mechanisms of the prodromal stages of psychosis. Psychosis risk symptoms are attenuated, transient, and often only retrospectively reported. The respective neuronal aberrations are thought being dynamic. The correlation of unstable psychopathology with observed, e. g., neurophysiological disturbances is thus yet largely unclear. In modeling psychosis, the experimental setting allows not only for evoking particular symptoms, but for the concomitant assessment of psychopathology, neurophysiology, and neuropsychology. Herein, the glutamatergic model will be highlighted exemplarily, with special emphasis on its potential contribution to the elucidation of psychosis development. This model of psychosis appears as candidate for modeling the prodrome since it induces psychopathological, neurocognitive and neurofunctional changes that are comparable to clinical features of the prodrome.As exemplarily illustrated by the PCP/NMDA model of psychosis many aspects advocate that prodromal stages might be validly mimicked by psychedelic substances. In summary, experimental psychiatry bears the potential to further elucidate the biological mechanisms of the psychosis

  11. Overview on the progress of tokamak experimental research in China

    International Nuclear Information System (INIS)

    Xie Jikang . E-mail; Liu Yong; Wen Yizhi; Wang Long

    2001-01-01

    Tokamak experimental research in China has made important progress. The main efforts were related to quasi-steady-state operation, LHCD, plasma heating with ICRF, IBW, NBI and ECRH, fuelling with pellets and supersonic molecular beams, and first wall conditioning techniques. Plasma parameters in the experiments were much improved, for example n e =8x10 19 m -3 and a plasma pulse length of >10 s were achieved. ICRF boronization and conditioning resulted in Z eff close to unity. Steady state full LH wave current drive has been achieved for more than 3 s. LHCD ramp-up and recharge have also been demonstrated. The best η CD exp ∼0.5(1+0.085exp(4.8(B T -1.45)))n e I CD R p /P LH =10 19 m -2 A W -1 . Quasi-steady-state H-mode-like plasmas with a density close to the Greenwald limit were obtained by LHCD, where the energy confinement time was nearly five times longer than in the ohmic case. The synergy between IBW, pellet and LHCD was tested. Research on the mechanism of macroturbulence has been extensively carried out experimentally. AC tokamak operation has been successfully demonstrated. (author)

  12. Hallucinogens and Dissociative Drugs, Including LSD, PCP, Ketamine, Dextromethorphan. National Institute on Drug Abuse Research Report Series.

    Science.gov (United States)

    National Inst. on Drug Abuse (DHHS/PHS), Rockville, MD.

    Research is developing a clearer picture of the dangers of mind-altering drugs. The goal of this report is to present the latest information to providers to help them strengthen their prevention and treatment efforts. A description is presented of dissociative drugs, and consideration is given as to why people take hallucinogens. The physical…

  13. Multivariate Analysis for Animal Selection in Experimental Research

    Directory of Open Access Journals (Sweden)

    Renan Mercuri Pinto

    2015-02-01

    Full Text Available Background: Several researchers seek methods for the selection of homogeneous groups of animals in experimental studies, a fact justified because homogeneity is an indispensable prerequisite for casualization of treatments. The lack of robust methods that comply with statistical and biological principles is the reason why researchers use empirical or subjective methods, influencing their results. Objective: To develop a multivariate statistical model for the selection of a homogeneous group of animals for experimental research and to elaborate a computational package to use it. Methods: The set of echocardiographic data of 115 male Wistar rats with supravalvular aortic stenosis (AoS was used as an example of model development. Initially, the data were standardized, and became dimensionless. Then, the variance matrix of the set was submitted to principal components analysis (PCA, aiming at reducing the parametric space and at retaining the relevant variability. That technique established a new Cartesian system into which the animals were allocated, and finally the confidence region (ellipsoid was built for the profile of the animals’ homogeneous responses. The animals located inside the ellipsoid were considered as belonging to the homogeneous batch; those outside the ellipsoid were considered spurious. Results: The PCA established eight descriptive axes that represented the accumulated variance of the data set in 88.71%. The allocation of the animals in the new system and the construction of the confidence region revealed six spurious animals as compared to the homogeneous batch of 109 animals. Conclusion: The biometric criterion presented proved to be effective, because it considers the animal as a whole, analyzing jointly all parameters measured, in addition to having a small discard rate.

  14. 42 CFR 2a.5 - Contents of application; research projects in which drugs will be administered.

    Science.gov (United States)

    2010-10-01

    ... application; research projects in which drugs will be administered. (a) In addition to the information... drug shall contain: (1) Identification of the drugs to be administered in the research project and a... project will be conducted. (b) An application for an authorization of confidentiality with respect to a...

  15. [Research Progress on Forensic Toxicology of Z-drugs].

    Science.gov (United States)

    Zhang, Yong-zhi; He, Hong-yuan; She, Cai-meng; Lian, Jie

    2015-08-01

    The Z-drugs (zolpidem, zopiclone, and zaleplon), as the innovative hypnotics, have an improvement over the traditional benzodiazepines in the management of insomnia. Z-drugs have significant hypnotic effects by reducing sleep latency and improving sleep quality, though duration of sleep may not be significantly increased. As benzodiazepines, Z-drugs exert their effects through increasing the transmission of γ-aminobutyric acid. Z-drugs overdose are less likely to be fatal, more likely would result in poisoning. Z-drugs can be detected in blood, urine, saliva, and other postmortem specimens through liquid chromatography-mass spectrometry techniques. Zolpidem and zaleplon exhibit significant postmortem redistribution. Z-drugs have improved pharmacokinetic profiles, but incidence of neuropsychiatric sequelae, poisoning, and death may prove to be similar to the other hypnotics. This review focuses on the pharmacology and toxicology of Z-drugs with respect to their adverse effect profile and toxicity and toxicology data in the field of forensic medicine.

  16. Interaction of anthraquinone anti-cancer drugs with DNA:Experimental and computational quantum chemical study

    Science.gov (United States)

    Al-Otaibi, Jamelah S.; Teesdale Spittle, Paul; El Gogary, Tarek M.

    2017-01-01

    Anthraquinones form the basis of several anticancer drugs. Anthraquinones anticancer drugs carry out their cytotoxic activities through their interaction with DNA, and inhibition of topoisomerase II activity. Anthraquinones (AQ4 and AQ4H) were synthesized and studied along with 1,4-DAAQ by computational and experimental tools. The purpose of this study is to shade more light on mechanism of interaction between anthraquinone DNA affinic agents and different types of DNA. This study will lead to gain of information useful for drug design and development. Molecular structures were optimized using DFT B3LYP/6-31 + G(d). Depending on intramolecular hydrogen bonding interactions two conformers of AQ4 were detected and computed as 25.667 kcal/mol apart. Molecular reactivity of the anthraquinone compounds was explored using global and condensed descriptors (electrophilicity and Fukui functions). Molecular docking studies for the inhibition of CDK2 and DNA binding were carried out to explore the anti cancer potency of these drugs. NMR and UV-VIS electronic absorption spectra of anthraquinones/DNA were investigated at the physiological pH. The interaction of the three anthraquinones (AQ4, AQ4H and 1,4-DAAQ) were studied with three DNA (calf thymus DNA, (Poly[dA].Poly[dT]) and (Poly[dG].Poly[dC]). NMR study shows a qualitative pattern of drug/DNA interaction in terms of band shift and broadening. UV-VIS electronic absorption spectra were employed to measure the affinity constants of drug/DNA binding using Scatchard analysis.

  17. Optimization of primaquine diphosphate tablet formulation for controlled drug release using the mixture experimental design.

    Science.gov (United States)

    Duque, Marcelo Dutra; Kreidel, Rogério Nepomuceno; Taqueda, Maria Elena Santos; Baby, André Rolim; Kaneko, Telma Mary; Velasco, Maria Valéria Robles; Consiglieri, Vladi Olga

    2013-01-01

    A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achieve this purpose, a 20-run, four-factor with multiple constraints on the proportions of the components was employed to obtain tablet compositions. Drug release was determined by an in vitro dissolution study in phosphate buffer solution at pH 6.8. The polynomial fitted functions described the behavior of the mixture on simplex coordinate systems to study the effects of each factor (polymer) on tablet characteristics. Based on the response surface methodology, a tablet composition was optimized with the purpose of obtaining a primaquine diphosphate release closer to a zero order kinetic. This formulation released 85.22% of the drug for 8 h and its kinetic was studied regarding to Korsmeyer-Peppas model, (Adj-R(2) = 0.99295) which has confirmed that both diffusion and erosion were related to the mechanism of the drug release. The data from the optimized formulation were very close to the predictions from statistical analysis, demonstrating that mixture experimental design could be used to optimize primaquine diphosphate dissolution from hidroxypropylmethyl cellulose and polyethylene glycol matrix tablets.

  18. Research at the Section of Experimental Nuclear Physics of ATOMKI

    International Nuclear Information System (INIS)

    Krasznahorkay, A.; Fenyes, T.; Dombradi, Zs.; Nyako, B.M.; Timar, J.; Algora, A.; Csatlos, M.; Csige, L.; Gacsi, Z.; Gulyas, J.

    2011-01-01

    Introduction. Nuclear physics research was started in Debrecen by Alexander Szalay (1909-1987) back in the 30's. He had been a postdoc of the Nobel-laureate biologist Albert Szent-Gyorgyi in Szeged and of Lord Rutherford in Cambridge. ATOMKI was founded in Debrecen later, in 1954. The Institute was meant to pursue scientific research in certain areas of experimental nuclear physics and to develop research instruments In the early years the country was pretty isolated, but the institute's state of isolation was gradually easing up from the mid-sixties. During the period 1962-1975 the research work was performed in collaboration with Joint Institute for Nuclear Research (Dubna), where up-to-date high-energy accelerators were available for the production of desired isotopes. After finishing the construction of a home-made 5 MV Van de Graaff accelerator (1972) and later on the installation of a K=20 light ion cyclotron (1985) the Institute has become the main centre of accelerator-based nuclear physics in Hungary. In the period 1975-1995 our group performed extensive nuclear structure studies in Debrecen by using γ and conversion electron spectroscopy. At the same time fruitful collaborations were initiated with Jyvaskyla (Finland), with University of Kentucky and University of Zagreb. In 1993 the former Nuclear Reaction Group (NRG) merged with our group. Parallel with this structural change, the main topics of our γ-spectroscopic work has also changed, which resulted that the location of our experiments were shifted from the home institute to foreign large-scale facilities. New topics were brought partly by the emerging NRG, partly by group members returning from postdoctoral fellowships. They also brought important non γ-spectroscopic topics, which enriched our research palette. These new topics have by now become joint endeavours involving more and more group members. The Nuclear Physics European Coordination Committee (NuPECC) has recently stated that the aim of

  19. Experimental And Theoretical High Energy Physics Research At UCLA

    Energy Technology Data Exchange (ETDEWEB)

    Cousins, Robert D. [University of California Los Angeles

    2013-07-22

    This is the final report of the UCLA High Energy Physics DOE Grant No. DE-FG02- 91ER40662. This report covers the last grant project period, namely the three years beginning January 15, 2010, plus extensions through April 30, 2013. The report describes the broad range of our experimental research spanning direct dark matter detection searches using both liquid xenon (XENON) and liquid argon (DARKSIDE); present (ICARUS) and R&D for future (LBNE) neutrino physics; ultra-high-energy neutrino and cosmic ray detection (ANITA); and the highest-energy accelerator-based physics with the CMS experiment and CERN’s Large Hadron Collider. For our theory group, the report describes frontier activities including particle astrophysics and cosmology; neutrino physics; LHC interaction cross section calculations now feasible due to breakthroughs in theoretical techniques; and advances in the formal theory of supergravity.

  20. Progress of experimental research on nuclear safety in NPIC

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Houjun; Zan, Yuanfeng; Peng, Chuanxin; Xi, Zhao; Zhang, Zhen; Wang, Ying; He, Yanqiu; Huang, Yanping [Nuclear Power Institute of China, Chengdu (China)

    2016-05-15

    Two kinds of Generation III commercial nuclear power plants have been developed in CNNC (China National Nuclear Corporation), one is a small modular reactor ACP100 having an equivalent electric power 100 MW, and the other is HPR1000 (once named ACP1000) having an equivalent electric power 1 000 MW. Both NPPs widely adopted the design philosophy of advanced passive safety systems and considered the lessons from Fukushima Daichi nuclear accident. As the backbone of the R and D of ACP100 and HPR1000, NPIC (Nuclear power Institute of China) has finished the engineering verification test of main safety systems, including passive residual heat removal experiments, reactor cavity injection experiments, hydrogen combustion experiments, and passive autocatalytic recombiner experiments. Above experimental work conducted in NPIC and further research plan of nuclear safety are introduced in this paper.

  1. Right to experimental treatment: FDA new drug approval, constitutional rights, and the public's health.

    Science.gov (United States)

    Leonard, Elizabeth Weeks

    2009-01-01

    On May 2, 2006, a divided panel of the U.S. Court of Appeals for the District of Columbia, in a startling opinion, Abigail Alliance for Better Access to Developmental Drugs v. Eschenbach, held that terminally ill patients who have exhausted all other available options have a constitutional right to experimental treatment that FDA has not yet approved. Although ultimately overturned by the full court, Abigail Alliance generated considerable interest from various constituencies. Meanwhile, FDA proposed similar regulatory amendments, as have lawmakers on both sides of the aisle in Congress. But proponents of expanded access fail to consider public health and consumer safety concerns. In particular, allowing patients to try unproven treatments, outside of controlled clinical trials risks both the study's outcome and the health of patients who might benefit from the deliberate, careful process of new drug approval as it currently operates under FDA's auspices.

  2. Inhibition of mild steel corrosion in acid solution by Pheniramine drug: Experimental and theoretical study

    Energy Technology Data Exchange (ETDEWEB)

    Ahamad, Ishtiaque [Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi 221 005 (India); Prasad, Rajendra [Department of Chemistry, SGB Amravati University, Amravati 444 602 (India); Quraishi, M.A., E-mail: maquraishi@rediffmail.co [Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi 221 005 (India)

    2010-09-15

    Inhibition of mild steel corrosion in 1 M HCl solution by Pheniramine drug was studied using weight loss, electrochemical impedance spectroscopy, linear polarization resistance, and potentiodynamic polarization measurements. The values of activation energy (E{sub a}) and different thermodynamic parameters such as adsorption equilibrium constant (K{sub ads}), free energy of adsorption ({Delta}G{sub ads}{sup o}), adsorption enthalpy ({Delta}H{sub ads}{sup o}) and adsorption entropy ({Delta}S{sub ads}{sup o}) were calculated and discussed. The adsorption process of studied drug on mild steel surface obeys the Langmuir adsorption isotherm. Potentiodynamic polarization measurements showed that Pheniramine is mixed-type inhibitor. Further, theoretical calculations were carried out and relations between computed parameters and experimental inhibition efficiency were discussed.

  3. Inhibition of mild steel corrosion in acid solution by Pheniramine drug: Experimental and theoretical study

    International Nuclear Information System (INIS)

    Ahamad, Ishtiaque; Prasad, Rajendra; Quraishi, M.A.

    2010-01-01

    Inhibition of mild steel corrosion in 1 M HCl solution by Pheniramine drug was studied using weight loss, electrochemical impedance spectroscopy, linear polarization resistance, and potentiodynamic polarization measurements. The values of activation energy (E a ) and different thermodynamic parameters such as adsorption equilibrium constant (K ads ), free energy of adsorption (ΔG ads o ), adsorption enthalpy (ΔH ads o ) and adsorption entropy (ΔS ads o ) were calculated and discussed. The adsorption process of studied drug on mild steel surface obeys the Langmuir adsorption isotherm. Potentiodynamic polarization measurements showed that Pheniramine is mixed-type inhibitor. Further, theoretical calculations were carried out and relations between computed parameters and experimental inhibition efficiency were discussed.

  4. Understanding mechanisms of toxicity: Insights from drug discovery research

    International Nuclear Information System (INIS)

    Houck, Keith A.; Kavlock, Robert J.

    2008-01-01

    Toxicology continues to rely heavily on use of animal testing for prediction of potential for toxicity in humans. Where mechanisms of toxicity have been elucidated, for example endocrine disruption by xenoestrogens binding to the estrogen receptor, in vitro assays have been developed as surrogate assays for toxicity prediction. This mechanistic information can be combined with other data such as exposure levels to inform a risk assessment for the chemical. However, there remains a paucity of such mechanistic assays due at least in part to lack of methods to determine specific mechanisms of toxicity for many toxicants. A means to address this deficiency lies in utilization of a vast repertoire of tools developed by the drug discovery industry for interrogating the bioactivity of chemicals. This review describes the application of high-throughput screening assays as experimental tools for profiling chemicals for potential for toxicity and understanding underlying mechanisms. The accessibility of broad panels of assays covering an array of protein families permits evaluation of chemicals for their ability to directly modulate many potential targets of toxicity. In addition, advances in cell-based screening have yielded tools capable of reporting the effects of chemicals on numerous critical cell signaling pathways and cell health parameters. Novel, more complex cellular systems are being used to model mammalian tissues and the consequences of compound treatment. Finally, high-throughput technology is being applied to model organism screens to understand mechanisms of toxicity. However, a number of formidable challenges to these methods remain to be overcome before they are widely applicable. Integration of successful approaches will contribute towards building a systems approach to toxicology that will provide mechanistic understanding of the effects of chemicals on biological systems and aid in rationale risk assessments

  5. Research on drug abuse and addiction treatment in prisons

    Directory of Open Access Journals (Sweden)

    Kljajević Srđan

    2017-01-01

    Full Text Available The causes of drug abuse and criminal behavior are closely linked. Not surprisingly, there is a high percentage of prisoners who during sentence execution abuse or are dependent on drugs. Antisocial personality disorder can be considered a common predictor of committing criminal offenses and drug abuse. A review of studies has revealed a high prevalence of inmates who use drugs while serving a sentence. Also, prison environment represents only a new context of the continuum of drug abuse by inmates. There are different theoretical approaches in explaining this phenomenon. Treatment programs based on empirically validated principles that guarantee the effectiveness, may be one strategy for solving the problem of drug abuse in prisons, with multiple positive effects.

  6. NASA IMAGESEER: NASA IMAGEs for Science, Education, Experimentation and Research

    Science.gov (United States)

    Le Moigne, Jacqueline; Grubb, Thomas G.; Milner, Barbara C.

    2012-01-01

    A number of web-accessible databases, including medical, military or other image data, offer universities and other users the ability to teach or research new Image Processing techniques on relevant and well-documented data. However, NASA images have traditionally been difficult for researchers to find, are often only available in hard-to-use formats, and do not always provide sufficient context and background for a non-NASA Scientist user to understand their content. The new IMAGESEER (IMAGEs for Science, Education, Experimentation and Research) database seeks to address these issues. Through a graphically-rich web site for browsing and downloading all of the selected datasets, benchmarks, and tutorials, IMAGESEER provides a widely accessible database of NASA-centric, easy to read, image data for teaching or validating new Image Processing algorithms. As such, IMAGESEER fosters collaboration between NASA and research organizations while simultaneously encouraging development of new and enhanced Image Processing algorithms. The first prototype includes a representative sampling of NASA multispectral and hyperspectral images from several Earth Science instruments, along with a few small tutorials. Image processing techniques are currently represented with cloud detection, image registration, and map cover/classification. For each technique, corresponding data are selected from four different geographic regions, i.e., mountains, urban, water coastal, and agriculture areas. Satellite images have been collected from several instruments - Landsat-5 and -7 Thematic Mappers, Earth Observing-1 (EO-1) Advanced Land Imager (ALI) and Hyperion, and the Moderate Resolution Imaging Spectroradiometer (MODIS). After geo-registration, these images are available in simple common formats such as GeoTIFF and raw formats, along with associated benchmark data.

  7. Measuring Diagnostic Stand for Experimental Researches in Technology Machining

    Directory of Open Access Journals (Sweden)

    A. E. Dreval'

    2014-01-01

    Full Text Available The paper reviews applied techniques, methods, and structure of the control and measuring means to conduct experimental and scientific researches of cutting processes. Existing research methods in cutting the metals are divided by features, such as essence of methods, the number of records of physical indicators, the number of studied factors, duration of tests. The groups of methods are briefly characterized.The chair "Tool Engineering and Technologies" of BMSTU developed and made a diagnostic stand of control and measurements for conducting research activities in the field of materials processing technology by cutting to define rational technological decisions, when machining, and carry out an analysis of efficiency and economic feasibility of made decisions. The diagnostic stand contains modern the electronic equipment. Record of measuring parameters is made in real time with a possibility for visual representation of read results and mathematical and statistical processing of measurement results. The stand can be used in research laboratories of machine-building enterprises, laboratories of higher education institutions, and other scientific divisions.The paper presents a justification that the stand is reasonable to use for the following: completion and choice of rational cutting modes, workability assessment of new constructional materials, technical and operational characteristics of the processed surfaces, and operational properties of the cutting tools of various producers, choice of optimum geometrical parameters of the cutting tools and brands of the lubricant cooling technological means, as well as the energy consumption for the chosen machining process. The stand allows us to make an assessment of wear resistance and tribology-technical characteristics of tool materials, as well as an accuracy, rigidity, vibration stability of machines, both new and being in operation.

  8. Sewage epidemiology and illicit drug research: the development of ethical research guidelines.

    Science.gov (United States)

    Prichard, Jeremy; Hall, Wayne; de Voogt, Pim; Zuccato, Ettore

    2014-02-15

    To discuss the need to develop ethical guidelines for researchers using sewage epidemiology to monitor drug use in the general population and specific precincts, including prisons, schools and workplaces. Describe current applications of sewage epidemiology, identify potential ethical risks associated with this science, and identify key means by which these risks may be mitigated through proportionate ethical guidance that allows this science to be fully developed. A rapidly advancing field of research is sewage epidemiology (SE) - the analysis of wastewater samples to monitor illicit drug use and other substances. Typically this research involves low ethical risks because individual participants cannot be identified and, consequently, review has been waived by human research ethics committees. In the absence of such oversight, ethical research guidelines are recommended for SE teams, peer reviewers and journal editors; guidelines will assist them to mitigate any risks in general population studies and studies of prisons, schools and workplaces. Potential harms include the stigmatisation of participants and, in the prison setting, austere policy responses to SE data that impact negatively upon inmate-participants. The risk of harm can be managed through research planning, awareness of the socio-political context in which results will be interpreted (or, in the case of media, sensationalised) and careful relations with industry partners. Ethical guidelines should be developed in consultation with SE scholars and be periodically amended. They should include publication processes that safeguard scientific rigour and be promulgated through existing research governance structures. Guidelines will assist to promote an ethical research culture among SE teams and scholars involved in the publication process and this will work to protect the reputation of the field. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Experimental research on electromagnetic radiation in inductive energy storage accelerator

    International Nuclear Information System (INIS)

    Zhong Jianzhong; Liu Lie; Li Limin; Wen Jianchun

    2008-01-01

    There exists strong electromagnetic radiation in inductive energy storage accelerators. In can destroy a measuring device at a distance. By repeated experiments, we found that it is a wide-spectrum electromagnetic wave with a main frequency of 75 MHz. The effector such as coaxial transmission line is effected strongly in short distance. The current in the coaxial transmission line can be measured in Rogowski coils. The strength of field in it is about 500 V/m and the peak current is 217 mA. The radiation source may be LC oscillating or electric exploding opening switch. Through the experimental research, we think it probably may be caused by the LC oscillating in the circuit when the switches conduct. And its strength is correlated to current change ratio. The change rate in secondary circuit is stronger than in primary circuit. So the radiation generated in secondary circuit is stronger than in primary circuit. It may be a reference for further research in inductive energy storage accelerators and shielding electromagnetic disturbing. (authors)

  10. Report of Activity, 1996 - 1997. Vol. 1. Experimental Research Division

    International Nuclear Information System (INIS)

    Brunelle, Alain; Morlet, Marcel; Hutin, Christiane

    1999-01-01

    This report presents the activity of Experimental Research Division of the Orsay Institute of Nuclear Physics on 1996 - 1997. The following 10 sections are represented through summary reports or short communications: 1. Nuclear structure far from stability (with the topics: 1.1. Exotic nuclei -Secondary beams of radioactive ions; 1.2. On-line spectroscopy; 1.3. Discrete high-spin states); 2. High excitation energy nuclear states; 3. Nuclear matter and nucleus-nucleus collisions (which includes 3.1. Evolution of reaction mechanisms from 10 to 150 MeV/u; 3.2. Hot nuclei; 3.3. Ultra-relativistic collisions); 4. Hadronic physics (with the topics: 4.1 Meson production; 4.2. Spin modes in nuclei; 4.3. Hadronic physics with electromagnetic probes); 5. Radiochemistry (with the sub-divisions: 5.1. Studies related to radioactive waste management; 5.2. Optical spectroscopy of actinide and lanthanide ions in solid media); 6. Inter-disciplinary research (with the topics: 6.1. Heavy ion and cluster interactions with matter and surfaces; 6.2. Medical imaging); 8. Teaching; 9. Publications - Conferences - Seminars; 10 Internal reports - Lectures - Theses - Patents. The scientific staff of the following groups is also presented: 1. Group of Nuclear Structure by Reactions; 2. Group of Heavy Ion Nuclear Physics; 3. Intermediary Energy Group; 4. Hadron Physics Group; 5. Nuclei-Ions-Matter Group; 6. Radiochemistry Group; 7. Group of Exotic Deformed Nuclei; 8. Group of Physics-Biology Interface

  11. Drug and alcohol crash risk : traffic safety facts : research note.

    Science.gov (United States)

    2015-02-01

    While the extent of use of alcohol by drivers and the risks posed by alcohol use have been well known for many decades, relatively little has been known about the use of other drugs by drivers and the associated risks. However, drug-impaired driving ...

  12. MYRRHA. An experimental ADS Facility for Research and Development

    International Nuclear Information System (INIS)

    Ait Abderrahim, H.

    2006-01-01

    Full text of publication follows: Since 1998, SCK-CEN in partnership with IBA s.a. and many European research laboratories, is designing a multipurpose ADS for R and D applications MYRRHA - and is conducting an associated R and D support programme. MYRRHA is an Accelerator Driven System (ADS) under development at Mol in Belgium and aiming to serve as a basis for the European experimental ADS to provide protons and neutrons for various R and D applications. It consists of a proton accelerator delivering a 350 MeV * 5 mA proton beam to a liquid Pb-Bi spallation target that in turn couples to a Pb-Bi cooled, subcritical fast core. In a first stage, the project focuses mainly on demonstration of the ADS concept, safety research on sub-critical systems and nuclear waste transmutation studies. In a later stage, the device will also be dedicated to research on structural materials, nuclear fuel, liquid metal technology and associated aspects and on sub-critical reactor physics. Subsequently, it will be used as fast spectrum irradiation facility and as radioisotope production facility. Along the above design features, the MYRRHA project team is developing the MYRRHA project as a multipurpose irradiation facility for R and D applications on the basis of an Accelerator Driven System (ADS). The project is intended to fit into the European strategy towards an ADS Demo facility for nuclear waste transmutation as described in the PDS-XADS FP5 Project. As such it should serve the following task catalogue: ADS concept demonstration, Safety studies for ADS, MA transmutation studies, LLFP transmutation studies, Medical radioisotopes, Material research, Fuel research. A first preliminary conceptual design file of MYRRHA was completed by the end of 2001 and has been reviewed by an International Technical Guidance Committee that concluded that there are no show stoppers in the project even thought some topics such as the safety studies and the fuel qualification need to be addressed

  13. Experimental research on intraocular aqueous flow by PIV method.

    Science.gov (United States)

    Yang, Hongyu; Song, Hongfang; Mei, Xi; Li, Lin; Fu, Xineng; Zhang, Mindi; Liu, Zhicheng

    2013-10-21

    Aqueous humor flows regularly from posterior chamber to anterior chamber, and this flow much involves intraocular pressure, the eye tissue nutrition and metabolism. To visualize and measure the intraocular flow regular pattern of aqueous humor. Intraocular flow in the vitro eyeball is driven to simulate the physiological aqueous humor flow, and the flow field is measured by Particle Image Velocimetry(PIV). Fluorescent particle solution of a certain concentration was infused into the root of Posterior Chamber(PC) of vitro rabbit eye to simulate the generation of aqueous and was drained out at a certain hydrostatic pressure from the angle of Anterior Chamber(AC) to represent the drainage of aqueous. PIV method was used to record and calculate the flow on the midsagittal plane of the eyeball. Velocity vector distribution in AC has been obtained, and the distribution shows symmetry feature to some extent. Fluorescent particle solution first fills the PC as it is continuously infused, then surges into AC through the pupil, flows upwards toward the central cornea, reflecting and scattering, and eventually converges along the inner cornea surface towards the outflow points at the periphery of the eyeball. Velocity values around the pupillary margin are within the range of 0.008-0.012 m/s, which are close to theoretical values of 0.0133 m/s, under the driving rate of 100 μl/min. Flow field of aqueous humor can be measured by PIV method, which makes it possible to study the aqueous humor dynamics by experimental method. Our study provides a basis for experimental research on aqueous humor flow; further, it possibly helps to diagnose and treat eye diseases as shear force damage of ocular tissues and destructions on corneal endothelial cells from the point of intraocular flow field.

  14. Performing Drug Safety Research During Pregnancy and Lactation: Biomedical HIV Prevention Research as a Template.

    Science.gov (United States)

    Beigi, Richard H; Noguchi, Lisa; Brown, Gina; Piper, Jeanna; Watts, D Heather

    2016-07-01

    Evidence-based guidance regarding use of nearly all pharmaceuticals by pregnant and lactating women is limited. Models for performing research may assist in filling these knowledge gaps. Internationally, reproductive age women are at high risk of human immunodeficiency virus (HIV) acquisition. Susceptibility to HIV infection may be increased during pregnancy, and risk of maternal-child transmission is increased with incident HIV infection during pregnancy and lactation. A multidisciplinary meeting of experts was convened at the United States National Institutes of Health to consider paradigms for drug research in pregnancy and lactation applicable to HIV prevention. This report summarizes the meeting proceedings and describes a framework for research on candidate HIV prevention agent use during pregnancy and lactation that may also have broader applications to other pharmaceutical products.

  15. Appropriate experimental approaches for predicting abuse potential and addictive qualities in preclinical drug discovery.

    Science.gov (United States)

    Mead, Andy N

    2014-11-01

    Drug abuse is an increasing social and public health issue, putting the onus on drug developers and regulatory agencies to ensure that the abuse potential of novel drugs is adequately assessed prior to product launch. This review summarizes the core preclinical data that frequently contribute to building an understanding of abuse potential for a new molecular entity, in addition to highlighting models that can provide increased resolution regarding the level of risk. Second, an important distinction between abuse potential and addiction potential is drawn, with comments on how preclinical models can inform on each. While the currently adopted preclinical models possess strong predictive validity, there are areas for future refinement and research. These areas include a more refined use of self-administration models to assess relative reinforcement; and the need for open innovation in pursuing improvements. There is also the need for careful scientifically driven application of models rather than a standardization of methodologies, and the need to explore the opportunities that may exist for enhancing the value of physical dependence and withdrawal studies by focusing on withdrawal-induced drug seeking, rather than broad symptomology.

  16. Experimental protocols for behavioral imaging: seeing animal models of drug abuse in a new light.

    Science.gov (United States)

    Aarons, Alexandra R; Talan, Amanda; Schiffer, Wynne K

    2012-01-01

    Behavioral neuroimaging is a rapidly evolving discipline that represents a marriage between the fields of behavioral neuroscience and preclinical molecular imaging. This union highlights the changing role of imaging in translational research. Techniques developed for humans are now widely applied in the study of animal models of brain disorders such as drug addiction. Small animal or preclinical imaging allows us to interrogate core features of addiction from both behavioral and biological endpoints. Snapshots of brain activity allow us to better understand changes in brain function and behavior associated with initial drug exposure, the emergence of drug escalation, and repeated bouts of drug withdrawal and relapse. Here we review the development and validation of new behavioral imaging paradigms and several clinically relevant radiotracers used to capture dynamic molecular events in behaving animals. We will discuss ways in which behavioral imaging protocols can be optimized to increase throughput and quantitative methods. Finally, we discuss our experience with the practical aspects of behavioral neuroimaging, so investigators can utilize effective animal models to better understand the addicted brain and behavior.

  17. 78 FR 8446 - Center for Drug Evaluation and Research; Prescription Drug Labeling Improvement and Enhancement...

    Science.gov (United States)

    2013-02-06

    ... utility of the prescription drug labeling as a communication tool and to discuss strategies for making it... the Web site after this document publishes in the Federal Register.) All holders of marketing... before June 30, 2001, and for generic drugs. The initiative is anticipated to take place over several...

  18. The ethics of HIV research with people who inject drugs in Africa: a desk review.

    Science.gov (United States)

    Mamotte, Nicole

    2012-03-01

    Injecting drug use is a growing problem in Africa and a growing risk factor for contracting HIV in the region. It is imperative that HIV research includes injecting drug users so that they too are able to benefit from safe and effective behavioural interventions and biomedical HIV prevention and treatment products. This article relates a critical review of the findings of a desk review of previously published literature. The article examines injecting drug use in relation to HIV-related risk and research in Kenya, Mauritius, Nigeria, South Africa and Tanzania. The ethical challenges of including people who inject drugs in HIV research in Africa are also presented. The review found injecting drug use to be on the increase in all the countries reviewed. HIV-risk behaviour among people who inject drugs, such as needle-sharing and higher-risk sexual behaviour, was also found to be widespread. Furthermore, criminalisation of drug use and strict anti-drug laws are common in the countries reviewed, while harm-reduction programmes for people who inject drugs were found to be limited. The review identified a number of ethical challenges to the involvement of people who inject drugs in HIV research in Africa. This includes the illegal status and stigma surrounding injecting drug use, which may complicate participant recruitment, enrolment and retention. In addition, a lack of funding for supportive programmes to help injecting drug users may hinder the provision of appropriate standards of prevention and care and treatment for those who seroconvert.

  19. Impact of Cost-Sharing Increases on Continuity of Specialty Drug Use: A Quasi-Experimental Study.

    Science.gov (United States)

    Li, Pengxiang; Hu, Tianyan; Yu, Xinyan; Chahin, Salim; Dahodwala, Nabila; Blum, Marissa; Pettit, Amy R; Doshi, Jalpa A

    2017-07-24

    To examine the impact of cost-sharing increases on continuity of specialty drug use in Medicare beneficiaries with multiple sclerosis (MS) or rheumatoid arthritis (RA). Five percent Medicare claims data (2007-2010). Quasi-experimental study examining changes in specialty drug use among a group of Medicare Part D beneficiaries without low-income subsidies (non-LIS) as they transitioned from a 5 percent cost-sharing preperiod to a ≥25 percent cost-sharing postperiod, as compared to changes among a disease-matched contemporaneous control group of patients eligible for full low-income subsidies (LIS), who faced minor cost sharing (≤$6.30 copayment) in both the pre- and postperiods. Key variables were extracted from Medicare data. Relative to the LIS group, the non-LIS group had a greater increase in incidence of 30-day continuous gaps in any Part D treatment from the lower cost-sharing period to the higher cost-sharing period (MS, absolute increase = 10.1 percent, OR = 1.61, 95% CI 1.19-2.17; RA, absolute increase = 21.9 percent, OR = 2.75, 95% CI 2.15-3.51). The increase in Part D treatment gaps was not offset by increased Part B specialty drug use. Cost-sharing increases due to specialty tier-level cost sharing were associated with interruptions in MS and RA specialty drug treatments. © Health Research and Educational Trust.

  20. EXPERIMENTAL RESEARCH REGARDING LEATHER APPLICATIONS IN PRODUCT DESIGN

    Directory of Open Access Journals (Sweden)

    PRALEA Jeni

    2015-05-01

    Full Text Available This paper presents the role and importance of experimental research in design activity. The designer, as a researcher and a project manager, proposes to establish a relationship between functional-aesthetic-constructive-technological-economic,based on the aesthetic possibilities of the materials used for the experiments. With the aim to identify areas for the application of leather waste resulted from the production process, the paper presents experiments conducted with this material in combination with wood, by using different techniques that lead to different aesthetic effects. Identifying the areas to use and creating products from leather and/or wood waste, is based on the properties of these materials. Leather, the subject of these experiments, has the advantage that it can be used on both sides. Tactile differences of the two sides of this material has both aesthetical and functional advantages, which makes it suitable for applications on products that meet the requirements of "design for all". With differentiated tactile characteristics, in combination with other materials, for these experiments wood, easily "read touch" products can be generated to help people with certain disabilities. Thus, experiments presented in this paper allows the establishment of aesthetic schemes applicable to products that are friendly both with the environment (based on the reuse of wood and leather waste and with the users (can be used as applications, accessories and concepts of products for people with certain disabilities. The designer’s choices or decisions can be based on the results of this experiment. The experiment enables the designer to develop creative, innovative and environmentally friendly products.

  1. Thermodynamics of nanoadsorption from solution: Theoretical and experimental research

    International Nuclear Information System (INIS)

    Wen, Yan-Zhen; Xue, Yong-Qiang; Cui, Zi-Xiang; Wang, Yan

    2015-01-01

    Highlights: • The thermodynamic theory of nanoadsorption was proposed. • The thermodynamic relations of nanoadsorption were derived. • The results of the experiments are accord with the theory. - Abstract: In this study, the effect of nanoparticle size on adsorption thermodynamics was investigated. The results of theoretical and experimental studies show that particle size significantly affects the equilibrium constant and thermodynamic properties of nanoadsorption. Relationships between the equilibrium constant, thermodynamic properties and particle size were derived using the thermodynamic theory of nanoadsorption. The equilibrium constant and thermodynamic properties were obtained by investigating the adsorption of Cu 2+ onto different sizes of nano-ZnO and the adsorption of Ag + onto different sizes of nano-TiO 2 . Good agreement was achieved between results obtained by experiments and predicted by theoretical analyses. The equilibrium constant and the molar Gibbs free energy of nanoadsorption were found to increase with smaller nanoparticle size. However, the effects of particle size on the molar enthalpy and the molar entropy are uncertain. In addition, the molar Gibbs free energy, the molar enthalpy, the molar entropy and the logarithm of the equilibrium constant are linearly related to the reciprocal of the diameter of the nanoparticle. The thermodynamic properties revealed in this study may provide important guidelines for research and application in the field of nanoadsorption

  2. Texas Experimental Tokamak, a plasma research facility: Technical progress report

    International Nuclear Information System (INIS)

    Wootton, A.J.

    1995-08-01

    In the year just past, the authors made major progress in understanding turbulence and transport in both core and edge. Development of the capability for turbulence measurements throughout the poloidal cross section and intelligent consideration of the observed asymmetries, played a critical role in this work. In their confinement studies, a limited plasma with strong, H-mode-like characteristics serendipitously appeared and received extensive study though a diverted H-mode remains elusive. In the plasma edge, they appear to be close to isolating a turbulence drive mechanism. These are major advances of benefit to the community at large, and they followed from incremental improvements in diagnostics, in the interpretation of the diagnostics, and in TEXT itself. Their general philosophy is that the understanding of plasma physics must be part of any intelligent fusion program, and that basic experimental research is the most important part of any such program. The work here demonstrates a continuing dedication to the problems of plasma transport which continue to plague the community and are an impediment to the design of future devices. They expect to show here that they approach this problem consistently, systematically, and effectively

  3. West African Journal of Pharmacology and Drug Research: Editorial ...

    African Journals Online (AJOL)

    Journal Ouest Africain de Pharmacologie et de Recherche sur les Médicaments) Papers on all aspects of drug action and related topics including chemotherapy and toxicology will be considered for publication.

  4. Research Article Antimalarial Drugs for Pediatrics - Prescribing and ...

    African Journals Online (AJOL)

    Erah

    2011-03-23

    Mar 23, 2011 ... is a need to institute measures to ensure rational prescribing, dispensing and use of antimalarial drugs in pediatrics. ... facilities, strategies to control behaviour in the private sector are ..... changes were implemented in 2006 in.

  5. [Application of operant conditioning techniques to forensic toxicology: experimental studies on alcohol and abusable drugs].

    Science.gov (United States)

    Hishida, S

    1996-10-01

    This paper describes some experiments that apply the operant conditioning techniques to forensic toxicological research. These techniques may be useful in investigating the mechanisms of action, toxic symptoms, legal competence and drug metabolism associated with substance abuse such as abuse of alcohol, psychotropic drugs, narcotics, stimulants, and organic solvents. 1) Genetic research on alcohol preference in rats. We applied operant conditioning to investigate alcohol preference in rats and constructed an apparatus for the measurement of discriminated operate responses for water or alcohol reinforcement in rat. This apparatus is a modified Skinner box with a one-lever two-liquid system. Fixed ratio-10 (FR-10) schedules of reinforcement are used to increase the work of the rat before it obtains the reinforcement. The voluntary choice of water or 10% ethanol by the rat can be assessed quantitatively by measuring the lever-pushing responses. It is an extremely useful method for measuring the real alcohol preference of rats. A rat was kept in a Skinner box overnight. The numbers of responses and reinforcement for water and ethanol and the volumes of the two liquids consumed were recorded. The ratio of ethanol reinforcement was defined as the number of ethanol reinforcement to the total number of ethanol and water reinforcement. The ratio of ethanol intake was defined as the volume of ethanol consumed to the volume of water and ethanol consumed. Ethanol consumption per g body weight was calculated from the volume of ethanol consumed by the rat. We used this apparatus to investigate alcohol preference of more than 300 Wistar Albino Rats, and divided them into a high alcohol preference (HAP) group and a low alcohol preference (LAP) group. Inbreeding between littermates was conducted in each of the HAP and LAP groups. The liver tissue of each offspring was obtained and the cytosol fraction was collected and subjected to isoelectric focusing using polyacrylamide gel

  6. Human experimental pain models: A review of standardized methods in drug development

    Directory of Open Access Journals (Sweden)

    K. Sunil kumar Reddy

    2012-01-01

    Full Text Available Human experimental pain models are essential in understanding the pain mechanisms and appear to be ideally suited to test analgesic compounds. The challenge that confronts both the clinician and the scientist is to match specific treatments to different pain-generating mechanisms and hence reach a pain treatment tailored to each individual patient. Experimental pain models offer the possibility to explore the pain system under controlled settings. Standardized stimuli of different modalities (i.e., mechanical, thermal, electrical, or chemical can be applied to the skin, muscles, and viscera for a differentiated and comprehensive assessment of various pain pathways and mechanisms. Using a multimodel-multistructure testing, the nociception arising from different body structures can be explored and modulation of specific biomarkers by new and existing analgesic drugs can be profiled. The value of human experimental pain models is to link animal and clinical pain studies, providing new possibilities for designing successful clinical trials. Spontaneous pain, the main compliant of the neuropathic patients, but currently there is no human model available that would mimic chronic pain. Therefore, current human pain models cannot replace patient studies for studying efficacy of analgesic compounds, although being helpful for proof-of-concept studies and dose finding.

  7. Beyond 'Doing Gender': Incorporating Race, Class, Place, and Life Transitions into Feminist Drug Research.

    Science.gov (United States)

    Miller, Jody; Carbone-Lopez, Kristin

    2015-05-01

    This essay draws from our research with US rural women methamphetamine users in 2009 to offer strategies for "revisioning" the drug use(r) field to better understand the impact of gender on drug use and drug market participation. We highlight the insights and limitations of a popular strategy in feminist research that conceptualizes gender as performance- commonly referred to as "doing gender"-using illustrations from our research. We encourage scholars to move beyond a primarily normative orientation in studying gender, and investigate gendered organizational features of social life including their intersections with other aspects of social inequality such as those of race, class, and place. In addition, we suggest that feminist scholars can integrate gender in a rigorous way into theoretical perspectives that are typically inattentive to its import, as a means of challenging, enriching, and refining research on drug use, drug users, and drug market participation.

  8. Annual tendency of research papers used ICR mice as experimental animals in biomedical research fields.

    Science.gov (United States)

    Kim, Ji Eun; Nam, Jung Hoon; Cho, Joon Young; Kim, Kil Soo; Hwang, Dae Youn

    2017-06-01

    Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research papers involving ICR mice in various biomedical fields has not been previously analyzed. In this study, we examined the numbers of papers that used ICR mice as experimental animals in the social science, natural science, engineering, medicine-pharmacy, marine agriculture-fishery, and art-kinesiology fields by analyzing big data. Numbers of ICR mouse-used papers gradually increased from 1961 to 2014, but small decreases were observed in 2015 and 2016. The largest number of ICR-used papers were published in the medicine-pharmacy field, followed by natural science and art-kinesiology fields. There were no ICR mouse-used papers in other fields. Furthermore, ICR mice have been widely employed in cell biology studies within the natural science field as well as in biochemistry and pathology in the medicine-pharmacy field. Few ICR mouse-used papers were published in exercise biochemistry and exercise nutrition in the art-kinesiology field. Regardless in most fields, the total numbers of published papers involving ICR mice were higher in 2014 than in other years, although the numbers in some fields including dentistry, veterinary science, and dermatology were high in 2016. Taken together, the present study shows that various ICR stocks, including Korl:ICR mice, are widely employed as experimental animals in various biomedical research fields.

  9. Research on Hygiene Based on Fieldwork and Experimental Studies.

    Science.gov (United States)

    Yajima, Ichiro

    2017-01-01

    Several experimental studies on hygiene have recently been performed and fieldwork studies are also important and essential tools. However, the implementation of experimental studies is insufficient compared with that of fieldwork studies on hygiene. Here, we show our well-balanced implementation of both fieldwork and experimental studies of toxic-element-mediated diseases including skin cancer and hearing loss. Since the pollution of drinking well water by toxic elements induces various diseases including skin cancer, we performed both fieldwork and experimental studies to determine the levels of toxic elements and the mechanisms behind the development of toxic-element-related diseases and to develop a novel remediation system. Our fieldwork studies in several countries including Bangladesh, Vietnam and Malaysia demonstrated that drinking well water was polluted with high concentrations of several toxic elements including arsenic, barium, iron and manganese. Our experimental studies using the data from our fieldwork studies demonstrated that these toxic elements caused skin cancer and hearing loss. Further experimental studies resulted in the development of a novel remediation system that adsorbs toxic elements from polluted drinking water. A well-balanced implementation of both fieldwork and experimental studies is important for the prediction, prevention and therapy of toxic-element-mediated diseases.

  10. Experimental and theoretical evaluation of nanodiamonds as pH triggered drug carriers

    KAUST Repository

    Yan, Jingjing

    2012-01-01

    Nanodiamond (ND) and its derivatives have been widely used for drug, protein and gene delivery. Herein, experimental and theoretical methods have been combined to investigate the effect of pH on the delivery of doxorubicin (DOX) from fluorescein labeled NDs (Fc-NDs). In the endosomal recycling process, the nanoparticle will pass from mildly acidic vesicle to pH ≈ 4.8; thus, it is important to investigate DOX release from NDs at different pH values. Fc-NDs released DOX dramatically under acidic conditions, while an increase in the DOX loading efficiency (up to 6.4 wt%) was observed under basic conditions. Further theoretical calculations suggest that H + weakens the electrostatistic interaction between ND surface carboxyl groups and DOX amino groups, and the interaction energies at pH < 7, pH 7 and pH > 7 are 10.4 kcal mol -1, 25.0 kcal mol -1 and 27.0 kcal mol -1 respectively. Cellular imaging experiments show that Fc-NDs are readily ingested by breast adenocarcinoma (BA) cells and cell viability tests prove that they can be utilized as a safe drug delivery vehicle. Furthermore, pH triggered DOX release has been tested in vitro (pH 7.4 and pH 4.83) in breast adenocarcinoma (BA) cells. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.

  11. West African Journal of Pharmacology and Drug Research

    African Journals Online (AJOL)

    (Journal Ouest Africain de Pharmacologie de Recherche sur les Medicaments). Papers on all aspects of drug action and related topics including chemotherapy and toxicology will be considered for publication. Vol 31, No 1 (2016). DOWNLOAD FULL TEXT Open Access DOWNLOAD FULL TEXT Subscription or Fee Access ...

  12. From research on rare diseases to new orphan drug development

    NARCIS (Netherlands)

    Heemstra, H.E.

    2010-01-01

    Rare diseases have a prevalence of lower than 5 in 10,000 inhabitants and are life-threatening or chronically debilitating. It is estimated that worldwide more than 5000 rare diseases exist, which account for over 55 million patients in the EU and the US together. However, the development of drugs

  13. Non-profit Drug Research and Development at a Crossroads.

    Science.gov (United States)

    Jarosławski, Szymon; Toumi, Mondher; Auquier, Pascal; Dussart, Claude

    2018-02-07

    In wealthy nations, non-profit drug R&D has been proposed to reduce the prices of medicines. We sought to review the ethical and economic issues concerning non-profit drug R&D companies, and the possible impact that their pricing strategy may have on the innovation efforts from for-profit companies targeting the same segment of the pharmaceutical market. There are two possible approaches to pricing drugs developed by non-profit R&D programs: pricing that maximises profits and "affordable" pricing that reflects the cost of manufacturing and distribution, plus a margin that ensures sustainability of the drug supply. Overall, the non-profits face ethical challenges - due to the lack of resources, they are unable to independently commercialize their products on a large scale; however, the antitrust law does not permit them to impose prices on potential licensees. Also, reduced prices for the innovative products may result in drying the for-profit R&D in the area.

  14. Experimental mechanics in research work and in practice

    International Nuclear Information System (INIS)

    1989-01-01

    The current state of the art in experimental mechanics is reflected and explained by the 34 conference papers of the 12th GESA symposium. Separate records of 12 papers have been prepared for the ENERGY database. (MM) [de

  15. Research Costs Investigated: A Study Into the Budgets of Dutch Publicly Funded Drug-Related Research.

    Science.gov (United States)

    van Asselt, Thea; Ramaekers, Bram; Corro Ramos, Isaac; Joore, Manuela; Al, Maiwenn; Lesman-Leegte, Ivonne; Postma, Maarten; Vemer, Pepijn; Feenstra, Talitha

    2018-01-01

    The costs of performing research are an important input in value of information (VOI) analyses but are difficult to assess. The aim of this study was to investigate the costs of research, serving two purposes: (1) estimating research costs for use in VOI analyses; and (2) developing a costing tool to support reviewers of grant proposals in assessing whether the proposed budget is realistic. For granted study proposals from the Netherlands Organization for Health Research and Development (ZonMw), type of study, potential cost drivers, proposed budget, and general characteristics were extracted. Regression analysis was conducted in an attempt to generate a 'predicted budget' for certain combinations of cost drivers, for implementation in the costing tool. Of 133 drug-related research grant proposals, 74 were included for complete data extraction. Because an association between cost drivers and budgets was not confirmed, we could not generate a predicted budget based on regression analysis, but only historic reference budgets given certain study characteristics. The costing tool was designed accordingly, i.e. with given selection criteria the tool returns the range of budgets in comparable studies. This range can be used in VOI analysis to estimate whether the expected net benefit of sampling will be positive to decide upon the net value of future research. The absence of association between study characteristics and budgets may indicate inconsistencies in the budgeting or granting process. Nonetheless, the tool generates useful information on historical budgets, and the option to formally relate VOI to budgets. To our knowledge, this is the first attempt at creating such a tool, which can be complemented with new studies being granted, enlarging the underlying database and keeping estimates up to date.

  16. Development of a Course-Based Undergraduate Research Experience to Introduce Drug-Receptor Concepts

    Directory of Open Access Journals (Sweden)

    Hollie I. Swanson

    2016-01-01

    Full Text Available Course-based research experiences (CUREs are currently of high interest due to their potential for engaging undergraduate students in authentic research and maintaining their interest in science, technology, engineering, and mathematics (STEM majors. As part of a campus-wide initiative called STEMCats , which is a living learning program offered to freshman STEM majors at the University of Kentucky funded by a grant from Howard Hughes Medical Institute, we have developed a CURE for freshmen interested in pursuing health care careers. Our course, entitled “Drug–Drug Interactions in Breast Cancer,” utilized a semester-long, in-class authentic research project and instructor-led discussions to engage students in a full spectrum of research activities, ranging from developing hypotheses and experimental design to generating original data, collaboratively interpreting results and presenting a poster at a campus-wide symposium. Student's feedback indicated a positive impact on scientific understanding and skills, enhanced teamwork and communication skills, as well as high student engagement, motivation, and STEM belonging. STEM belonging is defined as the extent to which a student may view the STEM fields as places where they belong. The results obtained from this pilot study, while preliminary, will be useful for guiding design revisions and generating appropriate objective evaluations of future pharmacological-based CUREs.

  17. 21 CFR 312.160 - Drugs for investigational use in laboratory research animals or in vitro tests.

    Science.gov (United States)

    2010-04-01

    ... research animals or in vitro tests. 312.160 Section 312.160 Food and Drugs FOOD AND DRUG ADMINISTRATION... Drugs for Investigational Use in Laboratory Research Animals or In Vitro Tests § 312.160 Drugs for investigational use in laboratory research animals or in vitro tests. (a) Authorization to ship. (1)(i) A person...

  18. Setting priorities for a research agenda to combat drug-resistant tuberculosis in children.

    Science.gov (United States)

    Velayutham, B; Nair, D; Ramalingam, S; Perez-Velez, C M; Becerra, M C; Swaminathan, S

    2015-12-21

    Numerous knowledge gaps hamper the prevention and treatment of childhood drug-resistant tuberculosis (TB). Identifying research priorities is vital to inform and develop strategies to address this neglected problem. To systematically identify and rank research priorities in childhood drug-resistant TB. Adapting the Child Health and Nutrition Research Initiative (CHNRI) methodology, we compiled 53 research questions in four research areas, then classified the questions into three research types. We invited experts in childhood drug-resistant TB to score these questions through an online survey. A total of 81 respondents participated in the survey. The top-ranked research question was to identify the best combination of existing diagnostic tools for early diagnosis. Highly ranked treatment-related questions centred on the reasons for and interventions to improve treatment outcomes, adverse effects of drugs and optimal treatment duration. The prevalence of drug-resistant TB was the highest-ranked question in the epidemiology area. The development type questions that ranked highest focused on interventions for optimal diagnosis, treatment and modalities for treatment delivery. This is the first effort to identify and rank research priorities for childhood drug-resistant TB. The result is a resource to guide research to improve prevention and treatment of drug-resistant TB in children.

  19. Binding of the neuroleptic drug, gabapentin, to bovine serum albumin: Insights from experimental and computational studies

    International Nuclear Information System (INIS)

    Jalali, Fahimeh; Dorraji, Parisa S.; Mahdiuni, Hamid

    2014-01-01

    The interaction between antiepileptic drug, gabapentin (GP), and bovin serum albumin (BSA) was studied by spectroscopic and computational methods. The native fluorescence of BSA was quenched by GP. Stern–Volmer quenching constant was calculated at different temperatures which suggested a static mechanism. The association constant (K a ) was calculated from fluorescence quenching studies, which increased with temperature rising. GP competed well with warfarine for hydrophobic subdomain IIA (Sudlow's site I) on the protein. Enthalpy and entropy changes during the interaction of GP with BSA were obtained using van't Hoff plot, which showed an entropy-driven process and involvement of hydrophobic forces (ΔH>0 and ΔS>0). Synchronous fluorescence measurements of BSA solution in the presence of GP showed a considerable blue shift when Δλ=15 nm, therefore, GP interacts with tyrosine-rich sites on BSA. Optimized docked model of BSA–GP mixture confirmed the experimental results. -- Highlights: • Interaction of gabapentin and bovine serum albumin (BSA) is investigated by spectroscopic techniques. • Gabapentin can quench the fluorescence of BSA through a static quenching procedure. • The binding of gabapentin to BSA is driven mainly by hydrophobic interactions. • Subdomain IIA (Sudlow's site I) of BSA is found to be the main binding site for gabapentin. • Molecular docking modeling confirmed the experimental results

  20. Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.

    Science.gov (United States)

    Fischer, Peter M

    2017-03-01

    Kinase inhibitor research is a comparatively recent branch of medicinal chemistry and pharmacology and the first small-molecule kinase inhibitor, imatinib, was approved for clinical use only 15 years ago. Since then, 33 more kinase inhibitor drugs have received regulatory approval for the treatment of a variety of cancers and the volume of reports on the discovery and development of kinase inhibitors has increased to an extent where it is now difficult-even for those working in the field-easily to keep an overview of the compounds that are being developed, as currently there are 231 such compounds, targeting 38 different protein and lipid kinases (not counting isoforms), in clinical use or under clinical investigation. The purpose of this review is thus to provide an overview of the biomedical rationales for the kinases being targeted on the one hand, and the design principles, as well as chemical, pharmacological, pharmaceutical, and toxicological kinase inhibitor properties, on the other hand. Two issues that are especially important in kinase inhibitor research, target selectivity and drug resistance, as well as the underlying structural concepts, are discussed in general terms and in the context of relevant kinases and their inhibitors. © 2016 Wiley Periodicals, Inc.

  1. A Unified Checklist for Observational and Experimental Research in Software Engineering (Version 1)

    NARCIS (Netherlands)

    Wieringa, Roelf J.

    2012-01-01

    Current checklists for empirical software engineering cover either experimental research or case study research but ignore the many commonalities that exist across all kinds of empirical research. Identifying these commonalities, and explaining why they exist, would enhance our understanding of

  2. Research of Ultrasound-Mediated Transdermal Drug Delivery System Using Cymbal-Type Piezoelectric Composite Transducer

    Science.gov (United States)

    Huan, Huiting; Gao, Chunming; Liu, Lixian; Sun, Qiming; Zhao, Binxing; Yan, Laijun

    2015-06-01

    Transdermal drug delivery (TDD) implemented by especially low-frequency ultrasound is generally known as sonophoresis or phonophoresis which has drawn considerable wide attention. However, TDD has not yet achieved its full potential as an alternative to conventional drug delivery methods due to its bulky instruments. In this paper, a cymbal-type piezoelectric composite transducer (CPCT) which has advantages over a traditional ultrasound generator in weight, flexibility, and power consumption, is used as a substitute ultrasonicator to realize TDD. First, theoretical research on a CPCT based on the finite element analysis was carried out according to which a series of applicable CPCTs with bandwidths of 20 kHz to 100 kHz were elaborated. Second, a TDD experimental setup was built with previously fabricated CPCTs aimed at the administration of glucose. Finally, the TDD performance of glucose molecule transport in porcine skin was measured in vitro by quantifying the concentration of glucose, and the time variation curves were subsequently obtained. During the experiment, the driving wave form, frequency, and power consumption of the transducers were selected as the main elements which determined the efficacy of glucose delivery. The results indicate that the effectiveness of the CPCT-based delivery is constrained more by the frequency and intensity of ultrasound rather than the driving waveform. The light-weight, flexibility, and low-power consumption of a CPCT can potentially achieve effective TDD.

  3. Plant natural products research in tuberculosis drug discovery and ...

    African Journals Online (AJOL)

    SAM

    2014-06-04

    Jun 4, 2014 ... Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and. Development ..... Anticancer. Cannabis sativa L. ... National Cancer Research Institute (NCI) at Frederick,.

  4. Experimental Advanced Airborne Research Lidar (EAARL) Data Processing Manual

    Science.gov (United States)

    Bonisteel, Jamie M.; Nayegandhi, Amar; Wright, C. Wayne; Brock, John C.; Nagle, David

    2009-01-01

    The Experimental Advanced Airborne Research Lidar (EAARL) is an example of a Light Detection and Ranging (Lidar) system that utilizes a blue-green wavelength (532 nanometers) to determine the distance to an object. The distance is determined by recording the travel time of a transmitted pulse at the speed of light (fig. 1). This system uses raster laser scanning with full-waveform (multi-peak) resolving capabilities to measure submerged topography and adjacent coastal land elevations simultaneously (Nayegandhi and others, 2009). This document reviews procedures for the post-processing of EAARL data using the custom-built Airborne Lidar Processing System (ALPS). ALPS software was developed in an open-source programming environment operated on a Linux platform. It has the ability to combine the laser return backscatter digitized at 1-nanosecond intervals with aircraft positioning information. This solution enables the exploration and processing of the EAARL data in an interactive or batch mode. ALPS also includes modules for the creation of bare earth, canopy-top, and submerged topography Digital Elevation Models (DEMs). The EAARL system uses an Earth-centered coordinate and reference system that removes the necessity to reference submerged topography data relative to water level or tide gages (Nayegandhi and others, 2006). The EAARL system can be mounted in an array of small twin-engine aircraft that operate at 300 meters above ground level (AGL) at a speed of 60 meters per second (117 knots). While other systems strive to maximize operational depth limits, EAARL has a narrow transmit beam and receiver field of view (1.5 to 2 milliradians), which improves the depth-measurement accuracy in shallow, clear water but limits the maximum depth to about 1.5 Secchi disk depth (~20 meters) in clear water. The laser transmitter [Continuum EPO-5000 yttrium aluminum garnet (YAG)] produces up to 5,000 short-duration (1.2 nanosecond), low-power (70 microjoules) pulses each second

  5. West African Journal of Pharmacology and Drug Research - Vol 21 ...

    African Journals Online (AJOL)

    Effect of methanolic extract of Asparagus pubescens root on non-vascular smooth muscle in experimental animals · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. P A Nwafor, F K Okwuasaba, M O Uguru, 31-36. http://dx.doi.org/10.4314/wajpdr.v21i1.14756 ...

  6. Experimental research on stability of covering blocks for sloping banks

    International Nuclear Information System (INIS)

    Okuno, Toshihiko

    1988-01-01

    In the case of constructing thermal and nuclear power stations facing open seas, usually the harbors for unloading fuel and others are constructed. In Japan, breakwaters are installed in the places of relatively shallow depth less than 20 m, and in such case, the sloping banks having the covering material of wave-controlling blocks made of concrete are mostly adopted as those are excellent in their function and economical efficiency, and are advantageous in the maintenance and management. Sloping banks are of such type that wave-controlling blocks cover the vertical front face of nonpermeating caissons, and the same type was adopted for breakwaters and others in Onagawa Nuclear Power Station, Tohoku Electric Power Co., Inc. As for the wave-controlling blocks, tetrapods and shake blocks were used. One of the most important problems in the design of sloping banks is how to estimate the stability of wave controlling blocks. In this paper, the results of the examination by hydraulic model experiment on the stability of covering blocks are reported, which are useful as the basic data for the rational and economical design of sloping banks. The experimental setup and a model bank, the generation of experimental waves and their characteristics, the experimental conditions and experimental method, and the results are reported. (Kako, I.)

  7. Sodium fires. Progress achieved in research and experimental results

    International Nuclear Information System (INIS)

    Malet, J.C.; Duverger de Cuy, G.; Casselman, C.; Charpenel, J.; Natta, M.; Devillers, C.

    1979-08-01

    This paper describes the sodium fire programs undertaken by the CEA's Nuclear Safety Department. Experimental results concerning sodium ignition and combustion, sodium fire suppression, sodium aerosol filtration and sodium-concrete contact reactions are given and the applications of these results in the Super-Phenix reactor is discussed

  8. Income inequality, drug-related arrests, and the health of people who inject drugs: Reflections on seventeen years of research.

    Science.gov (United States)

    Friedman, Samuel R; Tempalski, Barbara; Brady, Joanne E; West, Brooke S; Pouget, Enrique R; Williams, Leslie D; Des Jarlais, Don C; Cooper, Hannah L F

    2016-06-01

    This paper reviews and then discusses selected findings from a seventeen year study about the population prevalence of people who inject drugs (PWID) and of HIV prevalence and mortality among PWID in 96 large US metropolitan areas. Unlike most research, this study was conducted with the metropolitan area as the level of analysis. It found that metropolitan area measures of income inequality and of structural racism predicted all of these outcomes, and that rates of arrest for heroin and/or cocaine predicted HIV prevalence and mortality but did not predict changes in PWID population prevalence. Income inequality and measures of structural racism were associated with hard drug arrests or other properties of policing. These findings, whose limitations and implications for further research are discussed, suggest that efforts to respond to HIV and to drug injection should include supra-individual efforts to reduce both income inequality and racism. At a time when major social movements in many countries are trying to reduce inequality, racism and oppression (including reforming drug laws), these macro-social issues in public health should be both addressable and a priority in both research and action. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles.

    Science.gov (United States)

    Shin, Sangmun; Choi, Du Hyung; Truong, Nguyen Khoa Viet; Kim, Nam Ah; Chu, Kyung Rok; Jeong, Seong Hoon

    2011-04-04

    A new experimental design methodology was developed by integrating the response surface methodology and the time series modeling. The major purposes were to identify significant factors in determining swelling and release rate from matrix tablets and their relative factor levels for optimizing the experimental responses. Properties of tablet swelling and drug release were assessed with ten factors and two default factors, a hydrophilic model drug (terazosin) and magnesium stearate, and compared with target values. The selected input control factors were arranged in a mixture simplex lattice design with 21 experimental runs. The obtained optimal settings for gelation were PEO, LH-11, Syloid, and Pharmacoat with weight ratios of 215.33 (88.50%), 5.68 (2.33%), 19.27 (7.92%), and 3.04 (1.25%), respectively. The optimal settings for drug release were PEO and citric acid with weight ratios of 191.99 (78.91%) and 51.32 (21.09%), respectively. Based on the results of matrix swelling and drug release, the optimal solutions, target values, and validation experiment results over time were similar and showed consistent patterns with very small biases. The experimental design methodology could be a very promising experimental design method to obtain maximum information with limited time and resources. It could also be very useful in formulation studies by providing a systematic and reliable screening method to characterize significant factors in the sustained release matrix tablet. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Threats to the Internal Validity of Experimental and Quasi-Experimental Research in Healthcare.

    Science.gov (United States)

    Flannelly, Kevin J; Flannelly, Laura T; Jankowski, Katherine R B

    2018-01-24

    The article defines, describes, and discusses the seven threats to the internal validity of experiments discussed by Donald T. Campbell in his classic 1957 article: history, maturation, testing, instrument decay, statistical regression, selection, and mortality. These concepts are said to be threats to the internal validity of experiments because they pose alternate explanations for the apparent causal relationship between the independent variable and dependent variable of an experiment if they are not adequately controlled. A series of simple diagrams illustrate three pre-experimental designs and three true experimental designs discussed by Campbell in 1957 and several quasi-experimental designs described in his book written with Julian C. Stanley in 1966. The current article explains why each design controls for or fails to control for these seven threats to internal validity.

  11. Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity.

    Science.gov (United States)

    Zaletok, S P; Gulua, L; Wicker, L; Shlyakhovenko, V A; Gogol, S; Orlovsky, O; Karnaushenko, O V; Verbinenko, A; Milinevska, V; Samoylenko, O; Todor, I; Turmanidze, T

    2015-12-01

    To evaluate antitumor effect of plant polyphenol extracts from green tea, red wine lees and/or lemon peel alone and in combination with antitumor drugs on the growth of different transplanted tumors in experimental animals. Green tea extract (GTE) was prepared from green tea infusion. GTE-based composites of red wine (GTRW), lemon peel (GTRWL) and/or NanoGTE as well as corresponding nanocomposites were prepared. The total polyphenolics of the different GTE-based extracts ranged from 18.0% to 21.3%. The effects of GTE-based extracts were studied in sarcoma 180, Ehrlich carcinoma, B16 melanoma, Ca755 mammary carcinoma, P388 leukemia, L1210 leukemia, and Guerin carcinoma (original, cisplatin-resistant and doxorubicin-resistant variants). The extracts were administered as 0.1% solution in drinking water (0.6-1.0 mg by total polyphenolics per mouse per day and 4.0-6.3 mg per rat per day). Tumor growth inhibition (TGI) in mice treated with NanoGTE, cisplatin or cisplatin + NanoGTE was 27%, 55% and 78%, respectively, in Sarcoma 180%, 21%, 45% and 59%, respectively, in Ehrlich carcinoma; and 8%, 13% and 38%, respectively in B16 melanoma. Composites of NanoGTE, red wine, and lemon peel (NanoGTRWL) enhanced the antitumor effects of cyclophosphamide in mice with Ca755 mammary carcinoma. The treatment with combination of NanoGTE and inhibitors of polyamines (PA) synthesis (DFMO + MGBG) resulted in significant TGI of P388 leukemia (up to 71%) and L1210 leukemia. In rats transplanted with Guerin carcinoma (parental strain), treatment with GTRW or GTE alone resulted in 25-28% TGI vs. 55-68% TGI in cisplatin-treated animals. The inhibition observed in the case of combination of GTE or GTRW with cisplatin was additive giving 81-88% TGI. Similar effects were observed when combinations of the cytostatics with GTE (or NanoGTE) were tested against cisplatin- or doxorubicin-resistant Guerin carcinoma. Moreover, the plant extracts lowered side toxicity of the drugs. Treatment with GTE

  12. The Nonuse, Misuse, and Proper Use of Pilot Studies in Experimental Evaluation Research

    Science.gov (United States)

    Westlund, Erik; Stuart, Elizabeth A.

    2017-01-01

    This article discusses the nonuse, misuse, and proper use of pilot studies in experimental evaluation research. The authors first show that there is little theoretical, practical, or empirical guidance available to researchers who seek to incorporate pilot studies into experimental evaluation research designs. The authors then discuss how pilot…

  13. Personalized translational epilepsy research - Novel approaches and future perspectives: Part II: Experimental and translational approaches.

    Science.gov (United States)

    Bauer, Sebastian; van Alphen, Natascha; Becker, Albert; Chiocchetti, Andreas; Deichmann, Ralf; Deller, Thomas; Freiman, Thomas; Freitag, Christine M; Gehrig, Johannes; Hermsen, Anke M; Jedlicka, Peter; Kell, Christian; Klein, Karl Martin; Knake, Susanne; Kullmann, Dimitri M; Liebner, Stefan; Norwood, Braxton A; Omigie, Diana; Plate, Karlheinz; Reif, Andreas; Reif, Philipp S; Reiss, Yvonne; Roeper, Jochen; Ronellenfitsch, Michael W; Schorge, Stephanie; Schratt, Gerhard; Schwarzacher, Stephan W; Steinbach, Joachim P; Strzelczyk, Adam; Triesch, Jochen; Wagner, Marlies; Walker, Matthew C; von Wegner, Frederic; Rosenow, Felix

    2017-11-01

    Despite the availability of more than 15 new "antiepileptic drugs", the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20-30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain injury or to reverse established epilepsy have been identified to date. This is likely in part due to the polyetiologic nature of epilepsy, which in turn requires personalized medicine approaches. Recent advances in imaging, pathology, genetics, and epigenetics have led to new pathophysiological concepts and the identification of monogenic causes of epilepsy. In the context of these advances, the First International Symposium on Personalized Translational Epilepsy Research (1st ISymPTER) was held in Frankfurt on September 8, 2016, to discuss novel approaches and future perspectives for personalized translational research. These included new developments and ideas in a range of experimental and clinical areas such as deep phenotyping, quantitative brain imaging, EEG/MEG-based analysis of network dysfunction, tissue-based translational studies, innate immunity mechanisms, microRNA as treatment targets, functional characterization of genetic variants in human cell models and rodent organotypic slice cultures, personalized treatment approaches for monogenic epilepsies, blood-brain barrier dysfunction, therapeutic focal tissue modification, computational modeling for target and biomarker identification, and cost analysis in (monogenic) disease and its treatment. This report on the meeting proceedings is aimed at stimulating much needed investments of time and resources in personalized translational epilepsy research. This Part II includes the experimental and translational approaches and a discussion of the future perspectives, while the diagnostic methods, EEG network analysis, biomarkers, and personalized treatment approaches were addressed in Part I [1]. Copyright © 2017

  14. Experimental research on transient ionizing radiation effects of CMOS microcontroller

    International Nuclear Information System (INIS)

    Jin Xiaoming; Fan Ruyu; Chen Wei; Wang Guizhen; Lin Dongsheng; Yang Shanchao; Bai Xiaoyan

    2010-01-01

    This paper presents an experimental test system of CMOS microcontroller EE80C196KC20. Based on this system, the transient ionizing radiation effects on microcontroller were investigated using 'Qiangguang-I' accelerator. The gamma pulse width was 20 ns and the dose rate (for the Si atom) was in the range of 6.7 x 10 6 to 2.0 x 10 8 Gy/s in the experimental study. The disturbance and latchup effects were observed at different dose rate levels. Latchup threshold of the microcontroller was obtained. Disturbance interval and the system power supply current have a relationship with the dose rate level. The transient ionizing radiation induces photocurrent in the PN junctions that are inherent in CMOS circuits. The photocurrent is responsible for the electrical and functional degradation. (authors)

  15. [Experimental research on temporomandibular joint function in dysgnathic patients].

    Science.gov (United States)

    Hensel, S

    1990-10-01

    In an experimental study we examined the function of the TMJ of patients with a considerable aberration from ideal dynamic occlusion and with obvious symptoms of frontal dysgnathia. Using a measuring seat for the simultaneous recording of opening and closing movements without occlusal interference and the sounds produced by the TMJ, we could not find any significantly impaired TMJ function compared with an orthognathic control group of similar age.

  16. Experimental and Analytical Research on Fracture Processes in ROck

    Energy Technology Data Exchange (ETDEWEB)

    Herbert H.. Einstein; Jay Miller; Bruno Silva

    2009-02-27

    Experimental studies on fracture propagation and coalescence were conducted which together with previous tests by this group on gypsum and marble, provide information on fracturing. Specifically, different fracture geometries wsere tested, which together with the different material properties will provide the basis for analytical/numerical modeling. INitial steps on the models were made as were initial investigations on the effect of pressurized water on fracture coalescence.

  17. Neural Network Assisted Experimental Designs for Food Research

    Directory of Open Access Journals (Sweden)

    H.S. Ramaswamy

    2000-06-01

    Full Text Available The ability of artificial neural networks (ANN in predicting full factorial data from the fractional data corresponding to some of the commonly used experimental designs is explored in this paper. Factorial and fractional factorial designs such as L8, L9, L18, and Box and Behnken schemes were considered both in their original form and with some variations (L8+6, L15 and L9+1. Full factorial (3 factors x 5 levels and fractional data were generated employing sixteen different mathematical equations (four in each category: linear, with and without interactions, and non-linear, with and without interactions. Different ANN models were trained and the best model was chosen for each equation based on their ability to predict the fractional data. The best experimental design was then chosen based on their ability to simulate the full- factorial data for each equation. In several cases, the mean relative errors with the L18 design (which had more input data than other models were even higher than with other smaller fractional design. In general, the ANN assisted Lm, Box and Behnken, L15 and L18 designs were found to predict the full factorial data reasonably well with errors less than 5 %. The L8+6 model performed well with several experimental datasets reported in the literature.

  18. Antimony Resistance in Leishmania, Focusing on Experimental Research

    Directory of Open Access Journals (Sweden)

    Fakhri Jeddi

    2011-01-01

    Full Text Available Leishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases. There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alternative molecules. In this paper, we reviewed the studies carried out on antimonial resistance in Leishmania. Several common limitations of these works are presented before prevalent approaches to evidence antimonial resistance are related. Afterwards, phenotypic determination of resistance is described, then confronted to clinical outcome. Finally, we detail molecular mechanisms and targets involved in resistance and already identified in vitro within selected mutant strains or in clinical isolates.

  19. RESEARCH ARTICLE Genetic analysis of drug-metabolizing phase ...

    Indian Academy of Sciences (India)

    Navya

    Sorting intolerant from tolerant (SIFT) (http://sift.bii.a-star.edu.sg/) and .... science and technology research projects of Xizang (Tibet) Autonomous Region ..... color schemes, with bright red for very strong LD (LOD > 2, D'= 1), pink red (LOD >.

  20. Herbicide-induced experimental variegate porphyria in mice: tissue porphyrinogen accumulation and response to porphyrogenic drugs.

    Science.gov (United States)

    Krijt, J; Stranska, P; Maruna, P; Vokurka, M; Sanitrak, J

    1997-01-01

    Administration of oxadiazon or oxyfluorfen (1000 ppm in the diet) to male BALB/c mice for 9 days resulted in experimental porphyria, resembling the acute phase of human variegate porphyria. Urinary concentrations of 5-aminolevulinic acid and porphobilinogen reached 1500 and 3000 mumol/L, respectively. Both herbicides caused a decrease of protoporphyrinogen oxidase activity in liver and kidney. Brain protoporphyrinogen oxidase activity was not altered. Liver and kidney porphyrin content increased to 11 and 17 nmol/g, respectively (control mice, 2 nmol/g). Over 50% of liver and kidney porphyrins were in the reduced (porphyrinogen) form. Bile of oxadiazon-treated mice contained 700 nmol/mL of protoporphyrinogen (control mice, 15 nmol/mL). Porphyrin content of the trigeminal nerve increased from 1 nmol/g in control animals to 11 nmol/g in oxadiazon-treated animals, suggesting a possible contribution of peripheral nerve porphyrins to porphyric neuropathy. Mice treated with 125 ppm of oxadiazon in the diet for 9 days excreted moderately elevated levels of porphobilinogen in urine (control mice, less than 50 mumol/L; treated mice, 330 mumol/L). Administration of phenobarbital or phenytoin (single injections on days 7, 8, and 9) increased the urinary porphobilinogen concentration to 3500 mumol/L. This response to porphyrogenic drugs resembles the response observed in human acute porphyrias.

  1. Experimental model for research on the blood-ocular barrier

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hak Jin; Jea, Seung Youn; Park, Jae Sung; Jung, Yeon Joo [Pusan National University, Pusan (Korea, Republic of); Kim, Yong Woo [Inje University, Kimhae (Korea, Republic of); Park, Byung Rae [Catholic University, Seoul (Korea, Republic of)

    2006-03-15

    The eyeball has 2 blood-ocular barriers, i.e, the blood-retinal and blood-aqueous barriers. The purpose of this study was to evaluate if triolein emulsion could disrupt the barriers, and we wanted to suggest as an experimental model for future blood-ocular barrier studies. The triolein emulsion was made of 0.1 ml triolein and 20 ml normal saline, and this was infused into the carotid artery of ten cats (the experimental group). As a control group, only normal saline was infused in another ten cats. Precontrast and postcontrast T1-weighted MR images were obtained at 30 minutes and 3 hours after embolization in both groups. The signal intensities were evaluate qualitatively and quantitatively in the anterior and posterior chambers and also in the vitreus fluid. Statistical analysis was performed by employing the Kruskal Wallist test, Dunn's Multiple Comparison test and the wilcoxon signed rank test. In the control group, no contrast enhancement was demonstrated in the anterior or posterior chamber or in the vitreus fluid of the ipsilateral or contralateral eyeball on the 30 minutes MR images. The anterior chambers of the ipsilateral and contralateral eyeballs revealed delayed contrast enhancement on the 3 hour MR images. In the experimental group, the 30 minute-postembolization MR images were not different from those of the control group. The 30 minute-postembolization MR images demonstrated delayed contrast enhancement in the anterior chamber of the ipsilateral and contralateral eyeballs and in the posterior chamber of the ipsilateral eyeball. The delayed contrast enhancement of the posterior chamber of the ipsilateral eyeball was statistically significant ({rho} < 0.05). The present study demonstrated significant contrast enhancement in the posterior chamber with infusion of the triolein emulsion, and this can serve as a model for blood-aqueous barrier studies.

  2. Experimental model for research on the blood-ocular barrier

    International Nuclear Information System (INIS)

    Kim, Hak Jin; Jea, Seung Youn; Park, Jae Sung; Jung, Yeon Joo; Kim, Yong Woo; Park, Byung Rae

    2006-01-01

    The eyeball has 2 blood-ocular barriers, i.e, the blood-retinal and blood-aqueous barriers. The purpose of this study was to evaluate if triolein emulsion could disrupt the barriers, and we wanted to suggest as an experimental model for future blood-ocular barrier studies. The triolein emulsion was made of 0.1 ml triolein and 20 ml normal saline, and this was infused into the carotid artery of ten cats (the experimental group). As a control group, only normal saline was infused in another ten cats. Precontrast and postcontrast T1-weighted MR images were obtained at 30 minutes and 3 hours after embolization in both groups. The signal intensities were evaluate qualitatively and quantitatively in the anterior and posterior chambers and also in the vitreus fluid. Statistical analysis was performed by employing the Kruskal Wallist test, Dunn's Multiple Comparison test and the wilcoxon signed rank test. In the control group, no contrast enhancement was demonstrated in the anterior or posterior chamber or in the vitreus fluid of the ipsilateral or contralateral eyeball on the 30 minutes MR images. The anterior chambers of the ipsilateral and contralateral eyeballs revealed delayed contrast enhancement on the 3 hour MR images. In the experimental group, the 30 minute-postembolization MR images were not different from those of the control group. The 30 minute-postembolization MR images demonstrated delayed contrast enhancement in the anterior chamber of the ipsilateral and contralateral eyeballs and in the posterior chamber of the ipsilateral eyeball. The delayed contrast enhancement of the posterior chamber of the ipsilateral eyeball was statistically significant (ρ < 0.05). The present study demonstrated significant contrast enhancement in the posterior chamber with infusion of the triolein emulsion, and this can serve as a model for blood-aqueous barrier studies

  3. Experimental application of design principles in corrosion research

    International Nuclear Information System (INIS)

    Smyrl, W.H.; Pohlman, S.L.

    1977-01-01

    Experimental design criteria for corrosion investigations are based on established principles for systems that have uniform, or nearly uniform, corrosive attack. Scale-up or scale-down may be accomplished by proper use of dimensionless groups that measure the relative importance of interfacial kinetics, solution conductivity, and mass transfer. These principles have been applied to different fields of corrosion which include materials selection testing and protection; and to a specific corrosion problem involving attack of a substrate through holes in a protective overplate

  4. Experimental and numerical research on forging with torsion

    Science.gov (United States)

    Petrov, Mikhail A.; Subich, Vadim N.; Petrov, Pavel A.

    2017-10-01

    Increasing the efficiency of the technological operations of blank production is closely related to the computer-aided technologies (CAx). On the one hand, the practical result represents reality exactly. On the other hand, the development procedure of new process development demands unrestricted resources, which are limited on the SMEs. The tools of CAx were successfully applied for development of new process of forging with torsion and result analysis as well. It was shown, that the theoretical calculations find the confirmation both in praxis and during numerical simulation. The mostly used constructional materials were under study. The torque angles were stated. The simulated results were evaluated by experimental procedure.

  5. Experimental complex for high flux-materials interaction research

    International Nuclear Information System (INIS)

    Gagen-Torn, V.K.; Kirillov, I.R.; Komarov, V.L.; Litunovsky, V.N.; Mazul, I.V.; Ovchinnikov, I.B.; Prokofjev, Yu.G.; Saksagansky, G.L.; Titov, V.A.

    1995-01-01

    The experimental complex for high heat flux testing of divertor materials and bumper mock-ups under conditions close to both ITER stationary and plasma disruption PFC heat loads is described. High power plasma and electron beams are using as high heat flux sources. The former are applied to disruption simulation experiments. The values of pulsed plasma heat flux load up to 110 MJ/m 2 and stationary e-beam load up to 15 MW/m 2 can obtained on these facilities. (orig.)

  6. Changing children's eating behaviour - A review of experimental research

    DEFF Research Database (Denmark)

    DeCosta, Patricia Enebær Irene; Møller, Per; Frøst, Michael Bom

    2017-01-01

    programs, school gardens, sensory education, availability and accessibility, choice architecture and nudging, branding and food packaging, preparation and serving style, and offering a choice. In conclusion, controlling strategies for changing children's eating behaviour in a positive direction appear...... to be counterproductive. Hands-on approaches such as gardening and cooking programs may encourage greater vegetable consumption and may have a larger effect compared to nutrition education. Providing children with free, accessible fruits and vegetables have been experimentally shown to positively affect long-term eating...

  7. CHANGING METABOLIC FUNCTIONS IN EXPERIMENTAL ANIMALS AFTER INTRODUCTION OF THE XENOBIOTIC, IMMUNOTROPIC DRUG AND PROBIOTIC

    Directory of Open Access Journals (Sweden)

    Zvyagintseva O.V.

    2015-05-01

    Full Text Available The aim of the study was to evaluate in vivo changes in metabolic and barrier function of the resistance factors (activity of enzymes of neutrophils, the efficiency of phagocytosis, some biochemical parameters (concentration of ceruloplasmin and haptoglobin and proliferate activity in vitro cells after introduction of copper sulfate, probiotics and immunostimulant "Fungidol" the experimental animals. Material and methods. The in vivo experiments were performed on 6-month-old male rats of Wistar line. Identified the following groups: group 1 - control animals, which were intraperitoneally injected with saline (n = 5; group 2 - animals that were administered saline per os and 48 hours a solution of copper sulphate intraperitoneally (n = 5; group 3 - animals, which were injected with immunotropic drug "Fungidol" per os and 48 hours a solution of copper sulphate intraperitoneally (n = 5; group 4 animals, which were injected with a solution of probiotics per os and 48 hours a solution of copper sulphate intraperitoneally (n = 5. As a probiotic used capsules firm Yogurt that contains active Lactobacillus acidophilus, Lactobacillus rhamnosus, Streptococcus thermophillus, Lactobacillus bulgaricus. The concentration of haptoglobin and ceruloplasmin were determined spectrophotometrically. Oxygen-dependent metabolism of neutrophils was investigated by microscopy according to their ability to absorb nitroblue tetrazolium (NBT-test and restore it to deformazione in the form of granules blue color under the influence of superoxide anion, which is formed in the NADP-oxidase reaction, initiating the process of stimulation of phagocytosis (NBT-test. To determine the barrier function of phagocytic cells by light microscopy to evaluate the activity of phagocytosis of neutrophilic granulocytes with subsequent determination of phagocytic index, phagocytic number and the index of completeness of phagocytosis. As a microbial agent used is a suspension culture of

  8. Income inequality, drug-related arrests, and the health of people who inject drugs: Reflections on seventeen years of research

    OpenAIRE

    Friedman, Samuel R.; Tempalski, Barbara; Brady, Joanne E.; West, Brooke S.; Pouget, Enrique R.; Williams, Leslie D.; Des Jarlais, Don C.; Cooper, Hannah L.F.

    2016-01-01

    This paper reviews and then discusses selected findings from a seventeen year study about the population prevalence of people who inject drugs (PWID) and of HIV prevalence and mortality among PWID in 96 large US metropolitan areas. Unlike most research, this study was conducted with the metropolitan area as the level of analysis. It found that metropolitan area measures of income inequality and of structural racism predicted all of these outcomes, and that rates of arrest for heroin and/or co...

  9. 76 FR 81991 - National Spectrum Sharing Research Experimentation, Validation, Verification, Demonstration and...

    Science.gov (United States)

    2011-12-29

    ... NATIONAL SCIENCE FOUNDATION National Spectrum Sharing Research Experimentation, Validation... requirements of national level spectrum research, development, demonstration, and field trial facilities... to determine the optimal way to manage and use the radio spectrum. During Workshop I held at Boulder...

  10. Overview of experimental research on nuclear structure in department of modern applied physics

    International Nuclear Information System (INIS)

    Zhu Shengjiang

    1999-01-01

    The experimental research on nuclear structure in Department of Modern Applied Physics, Tsinghua University has been summarized. The main research results in high spin states of nuclear structure, as well as some low spin states, have been reported

  11. West African Journal of Pharmacology and Drug Research ...

    African Journals Online (AJOL)

    Search tips: Search terms are case-insensitive; Common words are ignored; By default only articles containing all terms in the query are returned (i.e., AND is implied); Combine multiple words with OR to find articles containing either term; e.g., education OR research; Use parentheses to create more complex queries; e.g., ...

  12. European community light water reactor safety research projects. Experimental issue

    International Nuclear Information System (INIS)

    1975-01-01

    Research programs on light water reactor safety currently carried out in the European Community are presented. They cover: accident conditions (LOCA, ECCS, core meltdown, external influences, etc...), fault and accident prevention and means of mitigation, normal operation conditions, on and off site implications and equipment under severe accident conditions, and miscellaneous subjects

  13. Technologies and experimental approaches in the NIH Botanical Research Centers

    Science.gov (United States)

    Barnes, Stephen; Birt, Diane F; Cassileth, Barrie R; Cefalu, William T; Chilton, Floyd H; Farnsworth, Norman R; Raskin, Ilya; van Breemen, Richard B; Weaver, Connie M

    2009-01-01

    There are many similarities between research on combinatorial chemistry and natural products and research on dietary supplements and botanicals in the NIH Botanical Research Centers. The technologies in the centers are similar to those used by other NIH-sponsored investigators. All centers rigorously examine the authenticity of botanical dietary supplements and determine the composition and concentrations of the phytochemicals therein, most often by liquid chromatography–mass spectrometry. Several of the centers specialize in fractionation and high-throughput evaluation to identify the individual bioactive agent or a combination of agents. Some centers are using DNA microarray analyses to determine the effects of botanicals on gene transcription with the goal of uncovering the important biochemical pathways they regulate. Other centers focus on bioavailability and uptake, distribution, metabolism, and excretion of the phytochemicals as for all xenobiotics. Because phytochemicals are often complex molecules, synthesis of isotopically labeled forms is carried out by plant cells in culture, followed by careful fractionation. These labeled phytochemicals allow the use of accelerator mass spectrometry to trace the tissue distribution of 14C-labeled proanthocyanidins in animal models of disease. State-of-the-art proteomics and mass spectrometry are also used to identify proteins in selected tissues whose expression and posttranslational modification are influenced by botanicals and dietary supplements. In summary, the skills needed to carry out botanical centers’ research are extensive and may exceed those practiced by most NIH investigators. PMID:18258642

  14. Research on the experimental verification of dosimetry calculations. Progress report

    International Nuclear Information System (INIS)

    Poston, J.W.

    1984-06-01

    Research has been focused on the development of a technique to section PATE organ dosimeters and the application of the technique to dosimetry of the extremities. In addition, a realistic model for the head and neck region has been designed and a model for the circulating blood has been proposed

  15. The pig as an experimental model for clinical craniofacial research

    Czech Academy of Sciences Publication Activity Database

    Štembírek, Jan; Kyllar, M.; Putnová, I.; Stehlík, L.; Buchtová, Marcela

    2012-01-01

    Roč. 46, č. 4 (2012), s. 269-279 ISSN 0023-6772 R&D Projects: GA ČR(CZ) GP304/08/P289 Institutional research plan: CEZ:AV0Z50450515 Keywords : platelet rich plasma * streptococcus suis serotype 2 * implant surface coatings Subject RIV: EG - Zoology Impact factor: 1.257, year: 2012

  16. Research interface for experimental ultrasound imaging - the CFU grabber project

    DEFF Research Database (Denmark)

    Pedersen, Mads Møller; Hemmsen, Martin Christian; Jensen, Jørgen Arendt

    system RASMUS. Furthermore precise scanner settings are stored for inter- and intra-observer studies. The resulting images are used for clinical evaluation. Method and materials The ultrasound scanners research interface is connected to a graphical grabber card in a Windows PC (Grabber PC). The grabber...

  17. Experimental Research at the Intensity Frontier in High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Marshak, Marvin L. [Univ. of Minnesota, Minneapolis, MN (United States)

    2014-06-30

    This Final Report describes DOE-supported Intensity Frontier research by the University of Minnesota during the interval April 1, 2011 to March 31, 2014. Primary activities included the MINOS, NOvA and LBNE Experiments and Heavy Quark studies at BES III.

  18. Para-Quantitative Methodology: Reclaiming Experimentalism in Educational Research

    Science.gov (United States)

    Shabani Varaki, Bakhtiar; Floden, Robert E.; Javidi Kalatehjafarabadi, Tahereh

    2015-01-01

    This article focuses on the criticisms of current approaches in educational research methodology. It summarizes rationales for mixed methods and argues that the mixing quantitative paradigm and qualitative paradigm is problematic due to practical and philosophical arguments. It is also indicated that the current rise of mixed methods work has…

  19. [Evaporation of selected cytotoxic drugs and permeation of protective gloves--research into the occupational risks of health care personnel handling hazardous cytotoxic drugs (CYTO project)].

    Science.gov (United States)

    Dolezalová, L; Odráska, P; Gorná, L; Prudilová, M; Vejpustková, R; Bláha, L

    2009-01-01

    The CYTO project studies an important aspect of healthcare provision -long-term occupational exposure, both threshold and below-threshold, to chemical agents with carcinogenic and mutagenic properties, with the major focus on antineoplastic drugs.This contribution presents experimental results from the first stages of the project's experimental work, i.e. an evaluation of the physico-chemical characteristics of cytostatic agents (evaporation) and an investigation into protective glove permeation. In co-operation with IUTA (Institut für Energie- und Umwelttechnik e.V., Duisburg, Germany), the vapour pressure of paclitaxel, doxorubicin and dacarbazine was measured following OECD guideline No. 104: Vapour pressure curve--vapour pressure balance. Furthermore, the evaporation of cytostatic drugs was examined in actual laboratory conditions by monitoring the airborne concentration using the passive sampling technique. Besides the evaporation of selected drugs, the permeation of cisplatin, cyclophosphamide, doxorubicin, 5-fluorouracil and paclitaxel through different types of gloves (vinyl, latex, nitrile) was assessed. Although our experiments showed relatively slow evaporation of the evaluated cytostatic drugs (the highest pressure in paclitaxel was 0.024 Pa), equilibrium concentrations may go up to milligrams per cubic metre. Nevertheless, analytical measurements of airborne contamination did not confirm these concentration levels. The glove permeation experiments with cytostatics showed good resistance of nitrile gloves (which were impermeable to all five drugs). Other materials should be avoided while handling cytostatic agents (e.g. maximum permeation of cyclophosphamide through latex was 19 microg/sq cm/hr). Although the volatility of cytostatic agents is low, it cannot be neglected considering the chronic character of exposure. However, in order to estimate actual occupational exposure, future research should focus on the development of sensitive analytical

  20. 78 FR 55728 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Science.gov (United States)

    2013-09-11

    ...) Modernizing FDA's Clinical Trials/BIMO Programs; (3) What FDA Expects in a Pharmaceutical Clinical Trial; (4) Medical Device Aspects of Clinical Research; (5) Adverse Event Reporting--Science, Regulation, Error, and...

  1. An experimental research program on chirality at the LHC

    International Nuclear Information System (INIS)

    Markert, Christina

    2016-01-01

    Heavy-ion collisions provide a unique opportunity to investigate the fundamental laws of physics of the strong force. The extreme conditions created by the collisions within a finite volume are akin to the properties of the deconfined partonic state which existed very shortly after the Big Bang and just prior to visible matter formation in the Universe. In this state massless quarks and gluons (partons) are ''quasi free'' particles, the so-called Quark Gluon Plasma (QGP). By following the expansion and cooling of this state, we will map out the process of nucleonic matter formation, which occurs during the phase transition. The fundamental properties of this early partonic phase of matter are not well understood, but they are essential for confirming QCD (Quantum Chromo-Dynamics) and the Standard Model. The specific topic, chiral symmetry restoration, has been called ''the remaining puzzle of QCD.'' This puzzle can only be studied in the dense partonic medium generated in heavy-ion collisions. The research objectives of this proposal are the development and application of new analysis strategies to study chirality and the properties of the medium above the QGP phase transition using hadronic resonances detected with the ALICE experiment at the Large Hadron Collider (LHC) at the CERN research laboratory in Switzerland. This grant funded a new effort at the University of Texas at Austin (UT Austin) to investigate the Quark Gluon Plasma (QGP) at the highest possible energy of 2.76 TeV per nucleon at the Large Hadron Collider (LHC) at CERN via the ALICE experiment. The findings added to our knowledge of the dynamical evolution and the properties of the hot, dense matter produced in heavy-ion collisions, and provided a deeper understanding of multi-hadron interactions in these extreme nuclear matter systems. Our group contributed as well to the hardware and software for the ALICE USA-funded Calorimeter Detector (EMCal). The LHC research program and its connection to

  2. CHOICE, PURCHASE AND CONSUMPTION OF DRUGS: SOCIOLOGICAL RESEARCH EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Ольга Викторовна Ткаченко

    2013-09-01

    Full Text Available The results of pharmaceutical market’s sociological research are representing in the paper. Determinate the basic agents influenced on pharmaceuticals choice and purchase such as a doctor, experience of individual, information from advertisement. Physician competency is of secondary importance to advertisement messages. Experience of individual prepotency of the pharmaceuticals choice raises a point of a level attention of pharmaceuticals consumer behavior. We can describe it in a low level both base on respondents self-conception and in accordance with data research of drug’s advertisement and patient package inserts «content-analysis».DOI: http://dx.doi.org/10.12731/2218-7405-2013-6-53

  3. An experimental investigation of recruitment bias in eating pathology research.

    Science.gov (United States)

    Moss, Erin L; von Ranson, Kristin M

    2006-04-01

    Previous, uncontrolled research has suggested a bias may exist in recruiting participants for eating disorder research. Recruitment biases may affect sample representativeness and generalizability of findings. This experiment investigated whether revealing that a study's topic was related to eating disorders created a self-selection bias. Young women at a university responded to advertisements containing contrasting information about the nature of a single study. We recruited one group by advertising the study under the title "Disordered Eating in Young Women" (n = 251) and another group using the title "Consumer Preferences" (n = 259). Results indicated similar levels of eating pathology in both groups, so the different recruitment techniques did not engender self-selection. However, the consumer preferences group scored higher in self-reported social desirability. The level of information conveyed in study advertising does not impact reporting of eating disturbances among nonclinical samples, although there is evidence social desirability might. 2006 by Wiley Periodicals, Inc.

  4. Field research program for unsaturated flow and transport experimentation

    International Nuclear Information System (INIS)

    Tidwell, V.C.; Rautman, C.A.; Glass, R.J.

    1992-01-01

    As part of the Yucca Mountain Site Characterization Project, a field research program has been developed to refine and validate models for flow and transport through unsaturated fractured rock. Validation of these models within the range of their application for performance assessment requires a more sophisticated understanding of the processes that govern flow and transport within fractured porous media than currently exists. In particular, our research is prioritized according to understanding and modeling processes that, if not accurately incorporated into performance assessment models, would adversely impact the project's ability to evaluate repository performance. For this reason, we have oriented our field program toward enhancing our understanding of scaling processes as they relate to effective media property modeling, as well as to the conceptual modeling of complex flow and transport phenomena

  5. Effects of some dopamine antagonists on spatial memory performance in rats--experimental research.

    Science.gov (United States)

    Rusu, Gabriela; Popa, Gratiela; Ochiuz, Lacramioara; Nechifor, M; Tartau, Liliana

    2014-01-01

    Dopamine is a neurotransmitter with an important role in forming long-lasting memories for some time, especially in episodic memory. Literature data show that dopamine receptor stimulation may be detrimental to spatial working memory functions in lab animals. (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride derivative--SCH-23390 is a synthetic compound that acts as a selective, high-affinity antagonist of D1 receptors. Experimental studies suggest that SCH 23390 may prevent the spatial working memory disturbances induced by the active substances of marijuana. Melperone is an atypic antipsychotic drug presenting also dopaminergic D2 and 5-HT2A receptor antagonistic activity. This neuroleptic agent is used in the treatment of some types of schizophrenia. Experimental research on the effects of two dopamine receptor antagonists on spatial memory performance in rats. The experiment was carried out in white Wistar rats (200-250g), divided into 3 groups of 7 animals each, treated intraperitoneally with the same volume of solution for 14 days, as follows: Group I (Control): saline solution 0.1 ml/10g kbw; Group II (coded SCH): SCH-23390 0.3 mg/kbw; Group III (coded MLP): melperone 2 mg/kbw. The dopaminergic agent spatial memory performance was assessed by recording spontaneous alternation behavior in a single session in Y-maze. Each animal was placed at the end of one arm and allowed to move freely through the maze during an 8 min session. Alternation was defined as a consecutive entry in three different arms. The alternation percentage was computed with the following formula: number of alternations divided by total number of arm visits minus 2. Data were presented as +/- standard deviation and significance was tested by SPSS Statistics for Windows version 13.0 and ANOVA method. P-values less than 0.05 were considered statistically significant compared to those in the control group. Experimental researches were carried out in

  6. Experimental and theoretical research in applied plasma physics

    International Nuclear Information System (INIS)

    Porkolab, M.

    1992-01-01

    This report discusses research in the following areas: fusion theory and computations; theory of thermonuclear plasmas; user service center; high poloidal beta studies on PBX-M; fast ECE fluctuation diagnostic for balloning mode studies; x-ray imaging diagnostic; millimeter/submillimeter-wave fusion ion diagnostics; small scale turbulence and nonlinear dynamics in plasmas; plasma turbulence and transport; phase contrast interferometer diagnostic for long wavelength fluctuations in DIII-D; and charged and neutral fusion production for fusio plasmas

  7. 21 CFR 20.105 - Testing and research conducted by or with funds provided by the Food and Drug Administration.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Testing and research conducted by or with funds... Categories of Records § 20.105 Testing and research conducted by or with funds provided by the Food and Drug Administration. (a) Any list that may be prepared by the Food and Drug Administration of testing and research...

  8. Publishing Single-Case Research Design Studies That Do Not Demonstrate Experimental Control

    Science.gov (United States)

    Tincani, Matt; Travers, Jason

    2018-01-01

    Demonstration of experimental control is considered a hallmark of high-quality single-case research design (SCRD). Studies that fail to demonstrate experimental control may not be published because researchers are unwilling to submit these papers for publication and journals are unlikely to publish negative results (i.e., the file drawer effect).…

  9. An annotated bibliography of scientific literature on research and management activities conducted in Coram Experimental Forest

    Science.gov (United States)

    Ilana Abrahamson; Katie Lyon

    2012-01-01

    The Coram Experimental Forest represents western larch-mixed conifer forests of the Northern Rockies. Western larch research was centered at Coram Experimental Forest (CEF) to provide a scientific basis to regenerate and grow this important and valuable species. For example, the long-term silvicultural studies installed at CEF are allowing researchers and managers to...

  10. [Research in experimental and theoretical high energy physics

    International Nuclear Information System (INIS)

    Bodek, A.; Ferbel, T.; Melissinos, A.C.

    1989-01-01

    The Experimental High Energy Physics Program is directed toward the execution of experiments at both national and international accelerator facilities. During the next fiscal year, we will be primarily concentrating on the following projects: Fermilab direct photon experiment E706; Tevatron proton-antiproton collider experiment D-Zero; Analysis of Fermilab neutrino experiments and hadron experiment; Analysis of SLAC experiment E140 and all previous SLAC data; Running of the SLAC E140 extension (approved to run in 89/90); SLAC experiment NE11 (ran in 1989); Brookhaven galactic axion experiment; Coherent production of axions and Dellbruck scattering at BNL; The AMY experiment at TRISTAN; and Laser Switched LINAC at the Rochester Laser Laboratory. Projects which are in the completion stages: Search for new states of matter using the Rochester Tandem and SLAC experiment E141 Axion search. Projects in study and planning stages: Nonlinear Compton Scattering at LEP; Production of hybrid mesons in the nuclear coulomb field; Neutrino experiment for the Tevatron upgrade and the SSC; and Involvement in the CDF upgrade and the SSC

  11. Methodology for the experimental research of vapor explosion

    International Nuclear Information System (INIS)

    Dmitriy I Borisenko; Yanhua Yang

    2005-01-01

    The method for experimental definition of influence of speed of fuel's surface increase at FCI is proposed. by modeling a fuel fragmentation for a case of falling of fuel compact weight on a coolant free surface with the help of the dumped heated up capsule opening under a level of a coolant free surface. Basic scheme of capsule is submitted in figure (the scheme of Dumped Opening Capsule (DOC)). Before beginning experiment through apertures in a covering 3 and a body of a case 4 in a hollow, limited to a case and the cylinder 6, spheres of small diameter have been incorporated. The total area of a surface of spheres is much more than area of external superficial of capsule. DOC is heated up to necessary temperature and it is fallen down in cooling a liquid. The principle work of DOC consists in the following. The plate 8, amazing about a free surface of a coolant, presses a pusher of 11 internal DOC. A pusher moving - relative DOC on axes of symmetry a teeth of compression of 'dog' 14. Being narrowed, teeth 'dogs' stop to hold a glass 7 installations bottom part of a case 5. At action of spring 13 parts of a case 4 and 5 moved separately on an axis of symmetry DOC and are enclosed in spheres adjoin to a coolant. (authors)

  12. Experimental research of double-pulse linear induction electron accelerator

    International Nuclear Information System (INIS)

    Liao Shuqing; Cheng Cheng; Zheng Shuxin; Tang Chuanxiang; Lin Yuzheng; Jing Xiaobing; Mu Fan; Pan Haifeng

    2009-01-01

    The Mini-LIA is a double-pulse linear induction electron accelerator with megahertz repetition rates, which consists of a double-pulse power system, a thermal cathode electron gun, two induction cells, beam transportation systems and diagnosis systems, etc. Experiments of the Mini-LIA have been conducted. The double-pulse high voltage was obtained with several hundred nanosecond pulse intervals (i. e. megahertz repetition rate) and each pulse had an 80 kV amplitude with a FWHM of 80 ns. In the gap of the induction cell, the double-pulse accelerating electric field was measured via E-field probes, and the double-pulse electron beam with a current about 1.1 A has been obtained at the Mini-LIA exit. These experimental results show that the double-pulse high voltage with megahertz repetition rates can be generated by an insulation and junction system. And they also indicate that the induction cell with metglas as the ferromagnetic material and the LaB 6 thermal cathode electron gun suit the double-pulse operation with megahertz repetition rates. (authors)

  13. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches.

    Science.gov (United States)

    Sánchez-Guerra, M; Pérez-Herrera, N; Quintanilla-Vega, B

    2011-11-01

    Non-persistent pesticides, such as organophosphorous (OP) insecticides have been extensively used in Mexico, and becoming a public health problem. This review presents data of OP use and related toxicity from epidemiological and experimental studies conducted in Mexico. Studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (AChE) activity (the main acute OP toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of Mexican farmers. OP exposure in occupational settings has been associated with decreased semen quality, sperm DNA damage and as endocrine disrupter, particularly in agricultural workers. Alterations in female reproductive function have also been observed, as well as adverse effects on embryo development by prenatal exposure in agricultural communities. This illustrates that OP exposure represents a risk for reproduction and offspring well-being in Mexico. The genotoxic effects of this group of pesticides in somatic and sperm cells are also documented. Lastly, we present data about gene-environmental interactions regarding OP metabolizing enzymes, such as paraoxonase-1 (PON1) and its role in modulating their toxicity, particularly on semen quality and sperm DNA integrity. In summary, readers will see the important health problems associated with OP exposure in Mexican populations, thereby the need of capacitation programs to communicate farmers the proper handling of agrochemicals to prevent their toxic effects and of more well designed human studies to support data of the current situation of workers and communities dedicated to agriculture activities.

  14. Controlled Nuclear Fusion Research, September 1965: Review Of Experimental Results

    Energy Technology Data Exchange (ETDEWEB)

    Spitzer, Lyman Jr. [Princeton University, Princeton, NJ (United States)

    1966-04-15

    To my way of thinking the most significant milestone of the present meeting is the substantial body of evidence that has been presented on the hydromagnetic stabilization of open-ended systems. The success of minimum magnetic-field ('minimum-B') configurations in stabilizing a plasma marks one more area where theory and experiment in the field of plasma physics have been brought together with gratifying results. Let me go back a little into history and discuss the gradual growth of our information on hydromagnetic instabilities generally. Many of you will remember that hydromagnetic theory was applied to the self-pinched discharge in the early years of the controUed fusion programme. The predictions of this theory were very shortly fulfilled by the observations; the effects were so unmistakable that it was not difficult to compare the theory with the observations. On the streak pictures of the linear or toroidal discharges that were obtained in those early years one saw clearly the diffuse plasma column, which first contracted to a narrow filament and then started to distort and kink until finally it hit the wall. Under some conditions the plasma was observed to break up into a series of blobs like a string of sausages. Since the behaviour was exactly what the theory had predicted, it took no very great experimental wisdom to conclude that observations had confirmed theory.

  15. Experimental parameters research for oxides of synthesis by microwave

    Energy Technology Data Exchange (ETDEWEB)

    Ratmann, Ezequiel Cafumann; Moreira, Mário Lúcio; Ratmann, Cristiane Raubach; Cava, Sergio da Silva, E-mail: ezequiel.ratmann@gmail.com [Universidade Federal de Pelotas (UFPEL), RS (Brazil)

    2016-07-01

    Full text: The objective of this study is to investigate the influence of experimental parameter of zinc oxide (ZnO) in the structural and optical properties obtained by a microwave-assisted solvo thermal method. The method consists in obtaining ZnO at temperatures from 90 - 140 °C and subsequently characterized structurally and verify possible variations in optical characteristics through photoluminescence measurements. The characterizations were performed by X-ray diffraction, scanning electron microscopy and photoluminescence measurements. The results show that the change in temperature of synthesis does not affect the crystal structure of ZnO. The photoluminescence measurements show a shift only in the sample obtained at 120 °C temperature. A more detailed study on the 120°C system is necessary to be able to say that the effect observed in the optical property is due to the method of synthesis. References: [1] S. R. Pinnell, D. Fairhurst, R. Gillies, M. A. Mitchnick, and N. Kollias. Microfine zinc oxide is a superior sunscreen ingredient to microfine titanium dioxide, Dermatologic surgery, vol. 26, no. 4, pp. 309-314, 2000; [2] Efracio M. Flores. Influência do solvente nas propriedades estruturais e ópticas de sistema ZnO@ZnS core-shell, obtidos pelo método solvotérmico assistido por microondas. Dissertação de Mestrado. 2015. (author)

  16. Age and impulsive behavior in drug addiction: A review of past research and future directions.

    Science.gov (United States)

    Argyriou, Evangelia; Um, Miji; Carron, Claire; Cyders, Melissa A

    2018-01-01

    Impulsive behavior is implicated in the initiation, maintenance, and relapse of drug-seeking behaviors involved in drug addiction. Research shows that changes in impulsive behavior across the lifespan contribute to drug use and addiction. The goal of this review is to examine existing research on the relationship between impulsive behavior and drug use across the lifespan and to recommend directions for future research. Three domains of impulsive behavior are explored in this review: impulsive behavior-related personality traits, delay discounting, and prepotent response inhibition. First, we present previous research on these three domains of impulsive behavior and drug use across developmental stages. Then, we discuss how changes in impulsive behavior across the lifespan are implicated in the progression of drug use and addiction. Finally, we discuss the relatively limited attention given to middle-to-older adults in the current literature, consider the validity of the measures used to assess impulsive behavior in middle-to-older adulthood, and suggest recommendations for future research. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Experimental Research of a New Wave Energy Conversion Device

    Science.gov (United States)

    Lu, Zhongyue; Shang, Jianzhong; Luo, Zirong; Sun, Chongfei; Chen, Gewei

    2018-01-01

    With the increasing tension of contemporary social energy, the development and utilization of renewable energy has become an important development direction. As an important part of renewable energy, wave energy has the characteristics of green environmental protection and abundant reserves, attracting more investment and research. For small marine equipment energy supply problem, this paper puts forward a micro wave energy conversion device as the basic of heaving motion of waves in the ocean. This paper designed a new type of power output device can solve the micro wave energy conversion problem.

  18. Oak Ridge National Laboratory Research Reactor Experimenters' Guide

    International Nuclear Information System (INIS)

    Cagle, C.D.

    1982-10-01

    The Oak Ridge National Laboratory has three multipurpose research reactors which accommodate testing loops, target irradiations, and beam-type experiments. Since the experiments must share common or similar facilities and utilities, be designed and fabricated by the same groups, and meet the same safety criteria, certain standards for these have been developed. These standards deal only with those properties from which safety and economy of time and money can be maximized and do not relate to the intent of the experiment or quality of the data obtained. The necessity for, and the limitations of, the standards are discussed; and a compilation of general standards is included

  19. Drug utilization research in primary health care as exemplified by physicians' quality assessment groups.

    Science.gov (United States)

    von Ferber, L; Luciano, A; Köster, I; Krappweis, J

    1992-11-01

    Drugs in primary health care are often prescribed for nonrational reasons. Drug utilization research investigates the prescription of drugs with an eye to medical, social and economic causes and consequences of the prescribed drug's utilization. The results of this research show distinct differences in drug utilization in different age groups and between men and women. Indication and dosage appear irrational from a textbook point of view. This indicates nonpharmacological causes of drug utilization. To advice successfully changes for the better quality assessment groups of primary health care physicians get information about their established behavior by analysis of their prescriptions. The discussion and the comparisons in the group allow them to recognize their irrational prescribing and the social, psychological and economic reasons behind it. Guidelines for treatment are worked out which take into account the primary health care physician's situation. After a year with 6 meetings of the quality assessment groups the education process is evaluated by another drug utilization analysis on the basis of the physicians prescription. The evaluation shows a remarkable improvement of quality and cost effectiveness of the drug therapy of the participating physicians.

  20. Does the theory-driven program affect the risky behavior of drug injecting users in a healthy city? A quasi-experimental study.

    Science.gov (United States)

    Karimy, Mahmood; Abedi, Ahmad Reza; Abredari, Hamid; Taher, Mohammad; Zarei, Fatemeh; Rezaie Shahsavarloo, Zahra

    2016-01-01

    The horror of HIV/AIDS as a non-curable, grueling disease is a destructive issue for every country. Drug use, shared needles and unsafe sex are closely linked to the transmission of HIV/AIDS. Modification or changing unhealthy behavior through educational programs can lead to HIV prevention. The aim of this study was to evaluate the efficiency of theory-based education intervention on HIV prevention transmission in drug addicts. In this quasi-experimental study, 69 male drug injecting users were entered in to the theory- based educational intervention. Data were collected using a questionnaire, before and 3 months after four sessions (group discussions, lecture, film displaying and role play) of educational intervention. The findings signified that the mean scores of constructs (self-efficacy, susceptibility, severity and benefit) significantly increased after the educational intervention, and the perceived barriers decreased (phistory of HIV testing was reported to be 9% before the intervention, while the rate increased to 88% after the intervention. The present research offers a primary founding for planning and implementing a theory based educational program to prevent HIV/AIDS transmission in drug injecting addicts. This research revealed that health educational intervention improved preventive behaviors and the knowledge of HIV/AIDS participants.

  1. Prescription Drugs: Abuse and Addiction. National Institute on Drug Abuse Research Report Series.

    Science.gov (United States)

    National Inst. on Drug Abuse (DHHS/PHS), Rockville, MD.

    This publication answers questions about the consequences of abusing commonly prescribed medications including opioids, central nervous system depressants, and stimulants. In addition to offering information on what research says about how certain medications affect the brain and body, this publication also discusses treatment options. It examines…

  2. Outlines of revised regulation standards for experimental research reactors

    International Nuclear Information System (INIS)

    Hohara, Shinya

    2015-01-01

    In response to the accident of TEPCO Fukushima Daiichi Nuclear Power Station, the government took actions through the revision of regulatory standards as well as the complete separation of regulation administrative department from promotion administrative department. The Nuclear and Industrial Safety Agency of the Ministry of Economy, Trade and Industry, which has been in charge of the regulations of commercial reactors, and the Office of Nuclear Regulations of the Ministry of Education, Culture, Sports, Science and Technology, which has been in charge of the regulations of reactors for experiment and research, were separated from both ministries, and integrated into the Nuclear Regulation Authority, which was newly established as the affiliated agency of the Ministry of the Environment. As for the revision of regulations and standards, the Nuclear Safety Commission was dismantled, and regulation enacting authority was given to the new Nuclear Regulation Authority, and the regulations that stipulated new regulatory standards were enacted. This paper outlines the contents of regulations related mainly to the reactors for experiment and research, and explains the following: (1) retroactive application of the new regulatory standards to existing reactor facilities, (2) examinations at the Nuclear Regulatory Agency, (3) procedures to confirm the compliance to the new standards, (4) seismic design classification, and (5) importance classification of safety function. (A.O.)

  3. Experimental and numerical research on cavitating flows around axisymmetric bodies

    International Nuclear Information System (INIS)

    Haipeng, Wei; Song, Fu; Qin, Wu; Biao, Huang; Guoyu, Wang

    2014-01-01

    We investigated the cavitating flows around different axisymmetric bodies based on experiments and numerical simulation. In the numerical simulation, the multiphase Reynolds averaged Navier Stokes equations (RANS) were solved via the commercial computational fluid dynamics code CFX. The modified k-wSST turbulence model was used along with the transport equation-based cavitation model. In the experiments, a high-speed video technique was used to observe the unsteady cavitating flow patterns, and the dynamic force measurement system was used to measure the hydrodynamics of the axisymmetric bodies under different cavitation conditions. Results are shown for the hemisphere bodies, conical bodies and blunt bodies. Reasonable agreements were obtained between the computational and experimental results. The results show that for the hemispherical body, the cavity consists of quasi-steady transparent region and unsteady foggy water-vapor mixture region, which contains small-scale vortices and is dominated by bubble clusters, causing irregular disturbances at the cavity interfaces. The curvature at the front of the conical body is larger, resulting in that the flow separates at the shoulder of the axisymmetric body. The cavity stretches downstream and reaches to a fixed cavity length and shape. For blunt bodies, the incipient cavitation number is larger than that for the hemispherical body. A large cloud cavity is formed at the shoulder of the blunt body in the cores of vortices in high shear separation regions and the re-entrant jet does not significantly interact with the cavity interface when it moves upstream. As to the dynamic characteristics of unsteady cavitating flows around the axisymmetric bodies, the pulsation frequency for the hemispherical body is larger than that for the blunt body. For the hemispherical body, the pulsation is mainly caused by the high-frequency, small-scale shedding at the rear end of the cavity, while for the blunt body, the main factor for

  4. Experimental studies on the ecology and evolution of drug-resistant malaria parasites

    OpenAIRE

    Huijben, Silvie

    2010-01-01

    Drug resistance is a serious problem in health care in general, and in malaria treatment in particular, rendering many of our previously considered ‘wonder drugs’ useless. Recently, large sums of money have been allocated for the continuous development of new drugs to replace the failing ones. We seem to be one step behind the evolution of antimalarial resistance; is it possible to get one step ahead? Are interventions which slow down the evolution and spread of drug-resistant ...

  5. Experimental particle physics research at Texas Tech University

    International Nuclear Information System (INIS)

    Akchurin, Nural; Lee, Sung-Won; Volobouev, Igor; Wigmans, Richard

    2016-01-01

    The high energy physics group at Texas Tech University (TTU) concentrates its research efforts on the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) and on generic detector R&D for future applications. Our research programs have been continuously supported by the US Department of Energy for over two decades, and this final report summarizes our achievements during the last grant period from May 1, 2012 to March 31, 2016. After having completed the Run 1 data analyses from the CMS detector, including the discovery of the Higgs boson in July 2012, we concentrated on commissioning the CMS hadron calorimeter (HCAL) for Run 2, performing analyses of Run 2 data, and making initial studies and plans for the second phase of upgrades in CMS. Our research has primarily focused on searches for Beyond Standard Model (BSM) physics via dijets, monophotons, and monojets. We also made significant contributions to the analyses of the semileptonic Higgs decays and Standard Model (SM) measurements in Run 1. Our work on the operations of the CMS detector, especially the performance monitoring of the HCAL in Run 1, was indispensable to the experiment. Our team members, holding leadership positions in HCAL, have played key roles in the R&D, construction, and commissioning of these detectors in the last decade. We also maintained an active program in jet studies that builds on our expertise in calorimetry and algorithm development. In Run 2, we extended some of our analyses at 8 TeV to 13 TeV, and we also started to investigate new territory, e.g., dark matter searches with unexplored signatures. The objective of dual-readout calorimetry R&D was intended to explore (and, if possible, eliminate) the obstacles that prevent calorimetric detection of hadrons and jets with a comparable level of precision as we have grown accustomed to for electrons and photons. The initial prototype detector was successfully tested at the SPS/CERN in 2003-2004 and evolved over the

  6. Experimental particle physics research at Texas Tech University

    Energy Technology Data Exchange (ETDEWEB)

    Akchurin, Nural [Texas Tech Univ., Lubbock, TX (United States); Lee, Sung-Won [Texas Tech Univ., Lubbock, TX (United States); Volobouev, Igor [Texas Tech Univ., Lubbock, TX (United States); Wigmans, Richard [Texas Tech Univ., Lubbock, TX (United States)

    2016-06-22

    The high energy physics group at Texas Tech University (TTU) concentrates its research efforts on the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) and on generic detector R&D for future applications. Our research programs have been continuously supported by the US Department of Energy for over two decades, and this final report summarizes our achievements during the last grant period from May 1, 2012 to March 31, 2016. After having completed the Run 1 data analyses from the CMS detector, including the discovery of the Higgs boson in July 2012, we concentrated on commissioning the CMS hadron calorimeter (HCAL) for Run 2, performing analyses of Run 2 data, and making initial studies and plans for the second phase of upgrades in CMS. Our research has primarily focused on searches for Beyond Standard Model (BSM) physics via dijets, monophotons, and monojets. We also made significant contributions to the analyses of the semileptonic Higgs decays and Standard Model (SM) measurements in Run 1. Our work on the operations of the CMS detector, especially the performance monitoring of the HCAL in Run 1, was indispensable to the experiment. Our team members, holding leadership positions in HCAL, have played key roles in the R&D, construction, and commissioning of these detectors in the last decade. We also maintained an active program in jet studies that builds on our expertise in calorimetry and algorithm development. In Run 2, we extended some of our analyses at 8 TeV to 13 TeV, and we also started to investigate new territory, e.g., dark matter searches with unexplored signatures. The objective of dual-readout calorimetry R&D was intended to explore (and, if possible, eliminate) the obstacles that prevent calorimetric detection of hadrons and jets with a comparable level of precision as we have grown accustomed to for electrons and photons. The initial prototype detector was successfully tested at the SPS/CERN in 2003-2004 and evolved over the

  7. Experimental psychiatric illness and drug abuse models: from human to animal, an overview.

    Science.gov (United States)

    Edwards, Scott; Koob, George F

    2012-01-01

    Preclinical animal models have supported much of the recent rapid expansion of neuroscience research and have facilitated critical discoveries that undoubtedly benefit patients suffering from psychiatric disorders. This overview serves as an introduction for the following chapters describing both in vivo and in vitro preclinical models of psychiatric disease components and briefly describes models related to drug dependence and affective disorders. Although there are no perfect animal models of any psychiatric disorder, models do exist for many elements of each disease state or stage. In many cases, the development of certain models is essentially restricted to the human clinical laboratory domain for the purpose of maximizing validity, whereas the use of in vitro models may best represent an adjunctive, well-controlled means to model specific signaling mechanisms associated with psychiatric disease states. The data generated by preclinical models are only as valid as the model itself, and the development and refinement of animal models for human psychiatric disorders continues to be an important challenge. Collaborative relationships between basic neuroscience and clinical modeling could greatly benefit the development of new and better models, in addition to facilitating medications development.

  8. Simulation and experimental research on line throwing rocket with flight

    Directory of Open Access Journals (Sweden)

    Wen-bin Gu

    2014-06-01

    Full Text Available The finite segment method is used to model the line throwing rocket system. A dynamic model of line throwing rocket with flight motion based on Kane's method is presented by the kinematics description of the system and the consideration of the forces acting on the system. The experiment designed according to the parameters of the dynamic model is made. The simulation and experiment results, such as range, velocity and flight time, are compared and analyzed. The simulation results are basically agreed with the test data, which shows that the flight motion of the line throwing rocket can be predicted by the dynamic model. A theoretical model and guide for the further research on the disturbance of rope and the guidance, flight control of line throwing rocket are provided by the dynamic modeling.

  9. Final report. [Research in theoretical and experimental elementary particle physics

    International Nuclear Information System (INIS)

    1998-01-01

    This report gives summaries of particle physics research conducted by different group members for Task A. A summary of work on the CLEO experiment and detector is included for Task B along with a list of CLEO publications. During the present grant period for Task C, the authors had responsibility for the design, assembly, and programming of the high-resolution spectrometer which looks for narrow peaks in the output of the cavity in the LLNL experiment. They successfully carried out this task. Velocity peaks are expected in the spectrum of dark matter axions on Earth. The computing proposal (Task S) is submitted in support of the High Energy Experiment (CLEO, Fermilab, CMS) and the Theory tasks

  10. The use of experimental animals in spa research

    Directory of Open Access Journals (Sweden)

    Iluta Alexandru

    2011-05-01

    Full Text Available A laboratory rat is a rat of species Rattus norvegicus which is bred and kept for scientific research. Laboratory rats have served as an important animal model for reaserch in psychology medicine , and other fields.Laboratory rats share origins with their cousins in domestication , the fancy rats. In 18th century Europe , wild Brown rats ran rampant and this infestation fueled the industry of rat-catching .Rat-cathcers would not only make money by trapping the rodents , but also by turning around and selling them for food , or more importantly , for rat-baiting . Rat-baiting was a popular sport which involved filling a pit with rats and timing how long it took for a terrier to kill them all.

  11. Microgrids research: A review of experimental microgrids and test systems

    Energy Technology Data Exchange (ETDEWEB)

    Lidula, N.W.A.; Rajapakse, A.D. [Department of Electrical and Computer Engineering, 75A Chancellor' s Circle, University of Manitoba, Winnipeg, Manitoba R3T 5V6 (Canada)

    2011-01-15

    A microgrid is particularly a portion of the power distribution system that comprises distributed generation, energy storage and loads. To be capable of operating in parallel to the grid, as an autonomous power island and in transition modes, microgrids must be robust in controlling the local voltage and frequency, and protecting the network and equipment connected to the microgrid. It also needs to facilitate demand side management and resynchronization. This paper presents a review of existing microgrid test networks around the world (North America, Europe and Asia) and some significantly different microgrid simulation networks present in the literature. Paper is focused on the test systems and available microgrid control options. A summary table comparing and contrasting the existing test systems is presented. The paper is concluded highlighting the worthy findings and possible areas of research that would enhance practical use of microgrid facilities. (author)

  12. Experimental research of radiogenic therapy on human melanoma

    International Nuclear Information System (INIS)

    Min Fengling; Chinese Academy of Sciences, Beijing; Zhang Hong; Li Wenjiang; Liu Bing; Zhou Qingming; Duan Xin; Zhou Guangming; Gao Qingxiang

    2006-01-01

    To investigate the effect of low dose irradiation on gene transfer efficiency and the effect of adenoviral-mediated exogenous P53 overexpression on radiosensitivity of radioresistant human melanoma cell line A375 with wild type p53, control vector, a replication deficient recombinant adenoviral vector containing a CMV promoter and green fluorescent protein (AdCMV-GFP), was used to transfect the A375 cells preirradiated with or without 1 Gy X-ray radiation. The transduction efficiency of GFP gene was determined with fluorescence microscope directly. A375 cells radiated by 1 Gy X-ray were transfected with a replication deficient recombinant adenoviral vector carrying human wild p53 were detected using flow cytometry (FCM) at different time after transfection. The radiosensitivity of A375 cells after p53 transduction was assayed by clonoy formation. The authors found that 1 Gy exposure increased the gene transfer efficiency of A375 cells. The expression of exogenous P53 was found to be 60% to 80% of transfected cells during the first three days after transduction and then declined continuously down to the control level on the day 10. The G1 cell cycle arrest was also observed after p53 gene transfer. A375 cells that were transfected with p53 showed higher sensitivity of X-ray-induced cell killing than those cells that either were transfected with the viral vector carrying a green fluorescent protein gene or were not transfected at all. Low dose ionizing radiation can improve gene transfer efficiency of A375 cells mediated by adenovirus vector. Althrough the overexpresion of exogenous P53 may not inhibit cell growth and induce apoptosis of melanoma cell line A375 in vitro, it made the tumor cells much sensitive to death by irradiation. the data suggested that p53 gene might be a potential gene for melanoma therapy and provide the experimental evidences to clinically using the combination of radiation with gene therapy on melanoma. Namely, there may be a reduction of

  13. A half century (1961-2011) of applying microsurgery to experimental liver research

    Science.gov (United States)

    Aller, Maria-Angeles; Arias, Natalia; Prieto, Isabel; Agudo, Salvador; Gilsanz, Carlos; Lorente, Laureano; Arias, Jorge-Luis; Arias, Jaime

    2012-01-01

    The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies. PMID:22855695

  14. The HIV and Drug Abuse Prevention Research Ethics Training Institute: Training Early-Career Scientists to Conduct Research on Research Ethics

    Science.gov (United States)

    Fisher, Celia B.; Yuko, Elizabeth

    2018-01-01

    The responsible conduct of HIV/drug abuse prevention research requires investigators with both the knowledge of and ability to generate empirical data that can enhance global ethical practices and policies. This article describes a multidisciplinary program offering early-career professionals a 2-year intensive summer curriculum along with funding to conduct a mentored research study on a wide variety of HIV/drug abuse research ethics topics. Now in its fifth year, the program has admitted 29 trainees who have to date demonstrated increased knowledge of research ethics, produced 17 peer-reviewed publications, 46 professional presentations, and submitted or been awarded five related federal grants. The institute also hosts a global information platform providing general and HIV/drug abuse relevant research ethics educational and research resources that have had more than 38,800 unique visitors from more than 150 countries. PMID:26564944

  15. The HIV and Drug Abuse Prevention Research Ethics Training Institute: Training Early-Career Scientists to Conduct Research on Research Ethics.

    Science.gov (United States)

    Fisher, Celia B; Yuko, Elizabeth

    2015-12-01

    The responsible conduct of HIV/drug abuse prevention research requires investigators with both the knowledge of and ability to generate empirical data that can enhance global ethical practices and policies. This article describes a multidisciplinary program offering early-career professionals a 2-year intensive summer curriculum along with funding to conduct a mentored research study on a wide variety of HIV/drug abuse research ethics topics. Now in its fifth year, the program has admitted 29 trainees who have to date demonstrated increased knowledge of research ethics, produced 17 peer-reviewed publications, 46 professional presentations, and submitted or been awarded five related federal grants. The institute also hosts a global information platform providing general and HIV/drug abuse relevant research ethics educational and research resources that have had more than 38,800 unique visitors from more than 150 countries. © The Author(s) 2015.

  16. Experimental Research on Boundary Shear Stress in Typical Meandering Channel

    Science.gov (United States)

    Chen, Kai-hua; Xia, Yun-feng; Zhang, Shi-zhao; Wen, Yun-cheng; Xu, Hua

    2018-06-01

    A novel instrument named Micro-Electro-Mechanical System (MEMS) flexible hot-film shear stress sensor was used to study the boundary shear stress distribution in the generalized natural meandering open channel, and the mean sidewall shear stress distribution along the meandering channel, and the lateral boundary shear stress distribution in the typical cross-section of the meandering channel was analysed. Based on the measurement of the boundary shear stress, a semi-empirical semi-theoretical computing approach of the boundary shear stress was derived including the effects of the secondary flow, sidewall roughness factor, eddy viscosity and the additional Reynolds stress, and more importantly, for the first time, it combined the effects of the cross-section central angle and the Reynolds number into the expressions. Afterwards, a comparison between the previous research and this study was developed. Following the result, we found that the semi-empirical semi-theoretical boundary shear stress distribution algorithm can predict the boundary shear stress distribution precisely. Finally, a single factor analysis was conducted on the relationship between the average sidewall shear stress on the convex and concave bank and the flow rate, water depth, slope ratio, or the cross-section central angle of the open channel bend. The functional relationship with each of the above factors was established, and then the distance from the location of the extreme sidewall shear stress to the bottom of the open channel was deduced based on the statistical theory.

  17. Experimental Researches Regarding the Ecological Dyeing with Natural Extracts

    Directory of Open Access Journals (Sweden)

    Budeanu Ramona

    2014-12-01

    Full Text Available The concept of ‘environmental awareness’ has recently had a major impact on the textile industry and on the fashion world as well. In this context, the use of natural fibres and the development of natural dyeing processes gradually became important goals of the textile industry. Of all natural textile fibres, hemp is considered to be one of the strongest and most durable. A wide range of natural extracts have been used for natural textile coloration and dyeing. Dyes deriving from natural sources have emerged as an important alternative to synthetic dyes. Ecofriendly, nontoxic, sustainable and renewable natural dyes and pigments have been used for colouring the food substrate, leather, wood, natural fibres and fabrics from the dawn of human history. The purpose of the research is to obtain ecologically coloured fabrics for textiles by using a method of dyeing that relies on natural ingredients extracted from red beet, onion leaves and black tea. The experiments are conducted on three different types of hemp fabrics. This paper presents the results of the studies regarding the dyeing process of hemp fabrics with natural extracts, the colours of the dyed samples inspected with reflectance spectra and the CIE L*a*b* colour space measurements.

  18. Experimental and theoretical high energy physics research. [UCLA

    Energy Technology Data Exchange (ETDEWEB)

    Buchanan, Charles D.; Cline, David B.; Byers, N.; Ferrara, S.; Peccei, R.; Hauser, Jay; Muller, Thomas; Atac, Muzaffer; Slater, William; Cousins, Robert; Arisaka, Katsushi

    1992-01-01

    Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics; (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R D.

  19. An Experimental Trial of Adaptive Programming in Drug Court: Outcomes at 6, 12 and 18 Months.

    Science.gov (United States)

    Marlowe, Douglas B; Festinger, David S; Dugosh, Karen L; Benasutti, Kathleen M; Fox, Gloria; Harron, Ashley

    2014-06-01

    Test whether an adaptive program improves outcomes in drug court by adjusting the schedule of court hearings and clinical case-management sessions pursuant to a priori performance criteria. Consenting participants in a misdemeanor drug court were randomly assigned to the adaptive program (n = 62) or to a baseline-matching condition (n = 63) in which they attended court hearings based on the results of a criminal risk assessment. Outcome measures were re-arrest rates at 18 months post-entry to the drug court and urine drug test results and structured interview results at 6 and 12 months post-entry. Although previously published analyses revealed significantly fewer positive drug tests for participants in the adaptive condition during the first 18 weeks of drug court, current analyses indicate the effects converged during the ensuing year. Between-group differences in new arrest rates, urine drug test results and self-reported psychosocial problems were small and non-statistically significant at 6, 12 and 18 months post-entry. A non-significant trend (p = .10) suggests there may have been a small residual impact (Cramer's ν = .15) on new misdemeanor arrests after 18 months. Adaptive programming shows promise for enhancing short-term outcomes in drug courts; however, additional efforts are needed to extend the effects beyond the first 4 to 6 months of enrollment.

  20. FDA Accelerates Testing and Review of Experimental Brain Cancer Drug | FNLCR

    Science.gov (United States)

    An investigational brain cancer drug made with disabled polio virus and manufactured at the Frederick National Lab has won breakthrough status from the Food and Drug Administration (FDA) to fast-track its further refinement and clinical testing.  Br

  1. FDA Accelerates Testing and Review of Experimental Brain Cancer Drug | FNLCR Staging

    Science.gov (United States)

    An investigational brain cancer drug made with disabled polio virus and manufactured at the Frederick National Lab has won breakthrough status from the Food and Drug Administration (FDA) to fast-track its further refinement and clinical testing.  Br

  2. Structured evaluation of rodent behavioral tests used in drug discovery research

    Directory of Open Access Journals (Sweden)

    Anders eHånell

    2014-07-01

    Full Text Available A large variety of rodent behavioral tests are currently being used to evaluate traits such as sensory-motor function, social interactions, anxiety-like and depressive-like behavior, substance dependence and various forms of cognitive function. Most behavioral tests have an inherent complexity, and their use requires consideration of several aspects such as the source of motivation in the test, the interaction between experimenter and animal, sources of variability, the sensory modality required by the animal to solve the task as well as costs and required work effort. Of particular importance is a test’s validity because of its influence on the chance of successful translation of preclinical results to clinical settings. High validity may, however, have to be balanced against practical constraints and there are no behavioral tests with optimal characteristics. The design and development of new behavioral tests is therefore an ongoing effort and there are now well over one hundred tests described in the contemporary literature. Some of them are well established following extensive use, while others are novel and still unproven. The task of choosing a behavioral test for a particular project may therefore be daunting and the aim of the present review is to provide a structured way to evaluate rodent behavioral tests aimed at drug discovery research.

  3. Recommendations to bridge rural/urban drug-use(r) research and practice.

    Science.gov (United States)

    Leukefeld, C G; Edwards, R W

    1999-01-01

    This article presents recommendations developed by a group of United States drug-use(r) researchers interested in rural and urban research and practice who met in Lexington, Kentucky, in October 1996. Overall, there was consensus about the importance of better understanding the urban/rural drug and alcohol use/dependency continuum. It was emphasized that drug and alcohol use/dependency are chronic and relapsing disorders. Definitions of rural and urban are most important, and different definitions may be associated with factors that are masked by population density. Specific recommendations are presented in the following areas: Rural Factors, Epidemiology, HIV/AIDS, Treatment and Other Services, Migration, Youth, Protective Factors, Systems Perspective, Measurement, Confidentiality, Criminal Justice, Research, Policy Research, Economic Factors, Service Providers, and Managed Care.

  4. Brain Chemistry and Behaviour: An Update on Neuroscience Research and Its Implications for Understanding Drug Addiction

    Science.gov (United States)

    Robinson, Emma S. J.

    2011-01-01

    Psychiatric disorders such as drug addiction represent one of the biggest challenges to society. This article reviews clinical and basic science research to illustrate how developments in research methodology have enabled neuroscientists to understand more about the brain mechanisms involved in addiction biology. Treating addiction represents a…

  5. NASA Experimental Program to Stimulate Competitive Research: South Carolina

    Science.gov (United States)

    Sutton, Michael A.

    2004-01-01

    The use of an appropriate relationship model is critical for reliable prediction of future urban growth. Identification of proper variables and mathematic functions and determination of the weights or coefficients are the key tasks for building such a model. Although the conventional logistic regression model is appropriate for handing land use problems, it appears insufficient to address the issue of interdependency of the predictor variables. This study used an alternative approach to simulation and modeling urban growth using artificial neural networks. It developed an operational neural network model trained using a robust backpropagation method. The model was applied in the Myrtle Beach region of South Carolina, and tested with both global datasets and areal datasets to examine the strength of both regional models and areal models. The results indicate that the neural network model not only has many theoretic advantages over other conventional mathematic models in representing the complex urban systems, but also is practically superior to the logistic model in its capability to predict urban growth with better - accuracy and less variation. The neural network model is particularly effective in terms of successfully identifying urban patterns in the rural areas where the logistic model often falls short. It was also found from the area-based tests that there are significant intra-regional differentiations in urban growth with different rules and rates. This suggests that the global modeling approach, or one model for the entire region, may not be adequate for simulation of a urban growth at the regional scale. Future research should develop methods for identification and subdivision of these areas and use a set of area-based models to address the issues of multi-centered, intra- regionally differentiated urban growth.

  6. «Dallas Buyers Club (2013» clinical research with drugs for the AIDS epidemic 80

    Directory of Open Access Journals (Sweden)

    Marian de HAAN-BOSCH

    2015-07-01

    Full Text Available Dallas Buyers Club (2013, inspired by true events, tells the story of Ron Woodroof, a middle?aged elec? trician from Dallas (Texas, who is diagnosed with AIDS in 1985. With few treatment options, he estab? lishes the Dallas Buyers Club in order to provide unapproved drugs to the AIDS community. This results in constant business travels, disputes with the FDA and problems with the law and the IRS. The article analyzes the buyers’ clubs phenomenon in the US, the drugs cited in the film and the clinical trial with zidovudine shown in the movie. The film could be useful as a teaching tool providing an introduction to the AIDS epidemic, clinical research and drug development, bioethics of human research and the agen? cies that regulate drug approval and their availability. Finally, the article presents a possible guideline for the use of the film in a teaching environment.

  7. Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

    Science.gov (United States)

    Willebrords, Joost; Pereira, Isabel Veloso Alves; Maes, Michaël; Yanguas, Sara Crespo; Colle, Isabelle; Van Den Bossche, Bert; Da silva, Tereza Cristina; Oliveira, Cláudia P; Andraus, Wellington; Alves, Venâncio Avancini Ferreira; Cogliati, Bruno; Vinken, Mathieu

    2015-01-01

    Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma. Non-alcoholic fatty liver disease is currently the most dominant chronic liver disease in Western countries due to the fact that hepatic steatosis is associated with insulin resistance, type 2 diabetes mellitus, obesity, metabolic syndrome and drug-induced injury. A variety of chemicals, mainly drugs, and diets is known to cause hepatic steatosis in humans and rodents. Experimental non-alcoholic fatty liver disease models rely on the application of a diet or the administration of drugs to laboratory animals or the exposure of hepatic cell lines to these drugs. More recently, genetically modified rodents or zebrafish have been introduced as non-alcoholic fatty liver disease models. Considerable interest now lies in the discovery and development of novel non-invasive biomarkers of non-alcoholic fatty liver disease, with specific focus on hepatic steatosis. Experimental diagnostic biomarkers of non-alcoholic fatty liver disease, such as (epi)genetic parameters and ‘-omics’-based read-outs are still in their infancy, but show great promise. . In this paper, the array of tools and models for the study of liver steatosis is discussed. Furthermore, the current state-of-art regarding experimental biomarkers such as epigenetic, genetic, transcriptomic, proteomic and metabonomic biomarkers will be reviewed. PMID:26073454

  8. Skin Permeation Enhancers and their Effects on Narcotic Transdermal Drug Delivery Systems through Response Surface Experimental Design

    Directory of Open Access Journals (Sweden)

    A. Moghimi

    2014-02-01

    Full Text Available Drug delivery through skin is often obstructed by low permeability of skin towards most drugs; however, such problem would be solved by application of skin penetration enhancers in the formulations. In the present study, a drug in adhesive patch with buprenorphine as active ingredient was prepared. Drug-in-adhesive transdermal drug delivery systems with different chemical penetration enhancers were designed. For this purpose a response-surface experimental design was used. Response surface methodology based on a three-level, three-variable Box–Behnken design was used to evaluate the interactive effects of dependent variables such as: the rate of skin permeation and adhesion properties including peel strength and tack value. The parameters such as drug release and adhesion were used as independent variables. Levulinic acid, lauryl alcohol and Tween 80 were used as penetration enhancers. In order to prepare samples, buprenorphine with constant concentration was incorporated into acrylic pressure sensitive adhesive with carboxylic functionality and this mixture was added to chemical penetration enhancer with different concentrations. The results show that the cumulative amount of drug release in presence of Tween 80 is 462.9 ± 0.006 μg so it is higher than cumulative amount of drug release in presence of levulinic acid (357.9 ± 0.005 μg and lauryl alcohol (269.5 ± 0.001 μg. Results of adhesion properties such as peel strength and tack reveal that using levulinic acid and lauryl alcohol will increase peel strength while Tween 80 will decrease it. Besides, the results show that all these permeation enhancers have increased tack values.

  9. Mathematical Modeling and Experimental Validation of Nanoemulsion-Based Drug Transport across Cellular Barriers.

    Science.gov (United States)

    Kadakia, Ekta; Shah, Lipa; Amiji, Mansoor M

    2017-07-01

    Nanoemulsions have shown potential in delivering drug across epithelial and endothelial cell barriers, which express efflux transporters. However, their transport mechanisms are not entirely understood. Our goal was to investigate the cellular permeability of nanoemulsion-encapsulated drugs and apply mathematical modeling to elucidate transport mechanisms and sensitive nanoemulsion attributes. Transport studies were performed in Caco-2 cells, using fish oil nanoemulsions and a model substrate, rhodamine-123. Permeability data was modeled using a semi-mechanistic approach, capturing the following cellular processes: endocytotic uptake of the nanoemulsion, release of rhodamine-123 from the nanoemulsion, efflux and passive permeability of rhodamine-123 in aqueous solution. Nanoemulsions not only improved the permeability of rhodamine-123, but were also less sensitive to efflux transporters. The model captured bidirectional permeability results and identified sensitive processes, such as the release of the nanoemulsion-encapsulated drug and cellular uptake of the nanoemulsion. Mathematical description of cellular processes, improved our understanding of transport mechanisms, such as nanoemulsions don't inhibit efflux to improve drug permeability. Instead, their endocytotic uptake, results in higher intracellular drug concentrations, thereby increasing the concentration gradient and transcellular permeability across biological barriers. Modeling results indicated optimizing nanoemulsion attributes like the droplet size and intracellular drug release rate, may further improve drug permeability.

  10. US Forest Service Experimental Forests and Ranges Network: a continental research platform for catchment-scale research

    Science.gov (United States)

    Daniel Neary; Deborah Hayes; Lindsey Rustad; James Vose; Gerald Gottfried; Stephen Sebesteyn; Sherri Johnson; Fred Swanson; Mary Adams

    2012-01-01

    The US Forest Service initiated its catchment research program in 1909 with the first paired catchment study at Wagon Wheel Gap, Colorado, USA. It has since developed the Experimental Forests and Ranges Network, with over 80 long-term research study sites located across the contiguous USA, Alaska, Hawaii, and the Caribbean. This network provides a unique, powerful...

  11. Research publications of the Cascade Head Experimental Forest and Scenic Research Area, Oregon Coast Range, 1934 to 1990.

    Science.gov (United States)

    Sarah E. Greene; Tawny Blinn

    1991-01-01

    A list of publications resulting from research at the Cascade Head Experimental Forest and Scenic Research Area, Siuslaw National Forest, Oregon, from 1934 to 1990 is presented. Over 200 publications are listed, including papers, theses, and reports. An index is provided that cross-references the listings under appropriate keywords.

  12. Natural products against cancer: A comprehensive bibliometric study of the research projects, publications, patents and drugs

    Directory of Open Access Journals (Sweden)

    Jian Du

    2014-01-01

    Full Text Available Objectives: To analyze multi-source data including awards, publications, patents and drugs, and try to draw the whole landscape of the research and development community in the area of natural products (NPs against cancer. Materials and Methods: Awards, publications, patents and drugs data from National Institute of Health/Natural Science Foundation of China (NIH/NSFC, PubMed, Derwent Innovation Index and Cortellis were collected. Bibliometric methodologies and technology are used to investigate publications/patents/drugs, their contents and relationships. Results: NIH and NSFC respectively demonstrated a stable and sustained expenditure growth in this area. The number of publications is continuously increasing. Yet the annual patent applications worldwide and FDA drug approvals were little changed or not obviously fluctuated in 2003-2013. USA and several Asia-pacific countries/territories are important contributing powers. We described the evolution of major research topics by those MeSH Major Topics indexed in PubMed with the largest growth range in three intervals, and analyzed hot research topics in the recent 10 years which include NPs or NPs derivatives, cell line/animal model, laboratory technologies and activation mechanisms. Conclusions: China published the most publications and received the most patent applications, but drug discovery performance is no better than USA and Japan. Research on anti-neoplastic structures and compounds originated from Chinese traditional medicine (TCM, medicinal plants, herbal medicine and marine NPs are major research topics in the recent 10 years. There still exits translational gap between basic research and drug discovery. Translational research should be undertaken to strengthen the applicability of NPs.

  13. Optimization of poorly compactable drug tablets manufactured by direct compression using the mixture experimental design.

    Science.gov (United States)

    Martinello, Tiago; Kaneko, Telma Mary; Velasco, Maria Valéria Robles; Taqueda, Maria Elena Santos; Consiglieri, Vladi O

    2006-09-28

    The poor flowability and bad compressibility characteristics of paracetamol are well known. As a result, the production of paracetamol tablets is almost exclusively by wet granulation, a disadvantageous method when compared to direct compression. The development of a new tablet formulation is still based on a large number of experiments and often relies merely on the experience of the analyst. The purpose of this study was to apply experimental design methodology (DOE) to the development and optimization of tablet formulations containing high amounts of paracetamol (more than 70%) and manufactured by direct compression. Nineteen formulations, screened by DOE methodology, were produced with different proportions of Microcel 102, Kollydon VA 64, Flowlac, Kollydon CL 30, PEG 4000, Aerosil, and magnesium stearate. Tablet properties, except friability, were in accordance with the USP 28th ed. requirements. These results were used to generate plots for optimization, mainly for friability. The physical-chemical data found from the optimized formulation were very close to those from the regression analysis, demonstrating that the mixture project is a great tool for the research and development of new formulations.

  14. BZP-party pills: a review of research on benzylpiperazine as a recreational drug.

    Science.gov (United States)

    Cohen, Bruce M Z; Butler, Rachael

    2011-03-01

    BZP-party pills are yet another 'designer drug' which mimics the stimulant qualities of amphetamines and MDMA/Ecstasy. As legal markets for the substance have developed in the last decade (especially amongst young people) so has public and governmental concern. This article provides a summary of the available international research on benzylpiperazine (BZP) and its popular use in the compound form known as 'party pills'. Through performing an analysis of the available medical and social scientific literature, the review outlines current knowledge on the compound, the prevalence of usage of BZP-party pills, as well as the associated harms, risks and rationales for use of the drug. Despite moves towards legislative control of BZP-party pills, the evidence presented suggests limited social and health harms associated with the drug, although research on long term effects is a significant gap in the literature. It also remains inconclusive as to whether BZP-party pills act as a 'gateway' to illegal drugs or, conversely, play a role in harm reduction with illegal drug users turning to legal alternatives; there is some evidence for both positions. With increasing controls of BZP-party pills, and with the increasing numbers of 'legal highs' and new designer drugs on the market, we conclude that new legal alternatives will continue to surface to replace the drug in the future. Considering a harm reduction approach to drug taking, it is suggested that policy makers consider the creation of a legal holding category which restricts and regulates the market in legal highs whilst the social and health harms associated with each drug can be thoroughly investigated. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. An annotated bibliography of scientific literature on research and management activities conducted in Manitou Experimental Forest

    Science.gov (United States)

    Ilana Abrahamson

    2012-01-01

    The Manitou Experimental Forest (MEF) is part of the USDA Forest Service Rocky Mountain Research Station. Established in 1936, its early research focused on range and watershed management. Currently, the site is home to several meteorological, ecological and biological research initiatives. Our collaborators include the University of Colorado, Colorado State University...

  16. Experimental research on passive residual heat remove system for advanced PWR

    International Nuclear Information System (INIS)

    Huang Yanping; Zhuo Wenbin; Yang Zumao; Xiao Zejun; Chen Bingde

    2003-01-01

    The experimental and qualified results of MISAP in the research of passive residual heat remove system of advanced PWR performed in the Bubble physics and natural circulation laboratory in Nuclear Power Institute of China in the past ten years is overviewed. Further researches for engineering research and design are also suggested

  17. [RESEARCH PROGRESS OF EXPERIMENTAL ANIMAL MODELS OF AVASCULAR NECROSIS OF FEMORAL HEAD].

    Science.gov (United States)

    Yu, Kaifu; Tan, Hongbo; Xu, Yongqing

    2015-12-01

    To summarize the current researches and progress on experimental animal models of avascular necrosis of the femoral head. Domestic and internation literature concerning experimental animal models of avascular necrosis of the femoral head was reviewed and analyzed. The methods to prepare the experimental animal models of avascular necrosis of the femoral head can be mainly concluded as traumatic methods (including surgical, physical, and chemical insult), and non-traumatic methods (including steroid, lipopolysaccharide, steroid combined with lipopolysaccharide, steroid combined with horse serum, etc). Each method has both merits and demerits, yet no ideal methods have been developed. There are many methods to prepare the experimental animal models of avascular necrosis of the femoral head, but proper model should be selected based on the aim of research. The establishment of ideal experimental animal models needs further research in future.

  18. Interrupted time series analysis in drug utilization research is increasing: systematic review and recommendations.

    Science.gov (United States)

    Jandoc, Racquel; Burden, Andrea M; Mamdani, Muhammad; Lévesque, Linda E; Cadarette, Suzanne M

    2015-08-01

    To describe the use and reporting of interrupted time series methods in drug utilization research. We completed a systematic search of MEDLINE, Web of Science, and reference lists to identify English language articles through to December 2013 that used interrupted time series methods in drug utilization research. We tabulated the number of studies by publication year and summarized methodological detail. We identified 220 eligible empirical applications since 1984. Only 17 (8%) were published before 2000, and 90 (41%) were published since 2010. Segmented regression was the most commonly applied interrupted time series method (67%). Most studies assessed drug policy changes (51%, n = 112); 22% (n = 48) examined the impact of new evidence, 18% (n = 39) examined safety advisories, and 16% (n = 35) examined quality improvement interventions. Autocorrelation was considered in 66% of studies, 31% reported adjusting for seasonality, and 15% accounted for nonstationarity. Use of interrupted time series methods in drug utilization research has increased, particularly in recent years. Despite methodological recommendations, there is large variation in reporting of analytic methods. Developing methodological and reporting standards for interrupted time series analysis is important to improve its application in drug utilization research, and we provide recommendations for consideration. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling.

    Science.gov (United States)

    Sims, Lee B; Frieboes, Hermann B; Steinbach-Rankins, Jill M

    2018-01-01

    A variety of drug-delivery platforms have been employed to deliver therapeutic agents across cervicovaginal mucus (CVM) and the vaginal mucosa, offering the capability to increase the longevity and retention of active agents to treat infections of the female reproductive tract (FRT). Nanoparticles (NPs) have been shown to improve retention, diffusion, and cell-specific targeting via specific surface modifications, relative to other delivery platforms. In particular, polymeric NPs represent a promising option that has shown improved distribution through the CVM. These NPs are typically fabricated from nontoxic, non-inflammatory, US Food and Drug Administration-approved polymers that improve biocompatibility. This review summarizes recent experimental studies that have evaluated NP transport in the FRT, and highlights research areas that more thoroughly and efficiently inform polymeric NP design, including mathematical modeling. An overview of the in vitro, ex vivo, and in vivo NP studies conducted to date - whereby transport parameters are determined, extrapolated, and validated - is presented first. The impact of different NP design features on transport through the FRT is summarized, and gaps that exist due to the limitations of iterative experimentation alone are identified. The potential of mathematical modeling to complement the characterization and evaluation of diffusion and transport of delivery vehicles and active agents through the CVM and mucosa is discussed. Lastly, potential advancements combining experimental and mathematical knowledge are suggested to inform next-generation NP designs, such that infections in the FRT may be more effectively treated.

  20. Experimental evaluation of the effects of drug information on antibiotic prescribing: a study in outpatient care in an area of Sri lanka.

    Science.gov (United States)

    Angunawela, I I; Diwan, V K; Tomson, G

    1991-06-01

    The intervention level of epidemiology is useful for studying effects in health systems research. Due to practical and ethical reasons, it is often difficult to apply experimental methods such as classical randomized clinical trials in the field. However with alternative approaches such as 'randomization by group' some of these problems can be overcome. Drug information has since long been considered as an instrument to influence physicians, however evaluation of its effects is a new field of research. In the present study the impact of drug information on prescribing behaviour was evaluated in an outpatient setting in Sri Lanka. The study included 15 state health institutions (45 prescribers) with a common drug formulary. Groups of prescribers were randomized into two interventions; newsletters and newsletters reinforced by a group seminar, and one control group. The target topic was 'rational prescribing of antibiotics'. Some 18,766 randomly selected outpatient drug prescriptions were studied. Antibiotics (and sulphonamides) were prescribed to 33.2% of the patients. An overall trend towards a decrease in proportion of patients prescribed antibiotics in the two intervention groups was seen, although the difference was not significant (p greater than 0.05) compared to the control group. This is similar to the effect of written information on prescribing in other studies. A mean difference of -7.4% in written, -7.3% in written + seminar and -0.4% in the control group was shown. The general antibiotic prescribing pattern did not change in any of the three groups. Penicillin was the most commonly prescribed antibiotic and tetracycline was only rarely prescribed to children. This experiment indicates the feasibility of drug information intervention studies in developing countries.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. An overview of criticality safety research at the All-Russian Research Institute of Experimental Physics

    Energy Technology Data Exchange (ETDEWEB)

    Kuvshinov, M.I.; Voinov, A.M.; Yuferev, V.I. [All-Russian Research Institute of Experimental Physics, Arzamas (Russian Federation)] [and others

    1997-06-01

    This paper presents a summary of experimental and calculational activities conducted at VNIIEF from the late 1940s to now to study the critical conditions of systems as part of a nuclear safety program. 9 refs., 1 tab.

  2. An overview of criticality safety research at the All-Russian Research Institute of Experimental Physics

    International Nuclear Information System (INIS)

    Kuvshinov, M.I.; Voinov, A.M.; Yuferev, V.I.

    1997-01-01

    This paper presents a summary of experimental and calculational activities conducted at VNIIEF from the late 1940s to now to study the critical conditions of systems as part of a nuclear safety program. 9 refs., 1 tab

  3. 76 FR 44593 - Identifying the Center for Drug Evaluation and Research's Science and Research Needs...

    Science.gov (United States)

    2011-07-26

    ... research needs outlined in the report, CDER hopes to stimulate research and foster collaborations with... research needs, CDER hopes to stimulate research and foster collaborations with external partners and... issues across teams, divisions, or offices; and (3) emerging scientific challenges. A comprehensive set...

  4. Four Years of Farmer Experimentation on Soil Fertility in Tigray, Northern Ethiopia: Trends in Research Strategies

    Science.gov (United States)

    Kraaijvanger, Richard G.; Veldkamp, Tom

    2017-01-01

    Purpose: This paper analyses research strategies followed by farmer groups in Tigray, that were involved in participatory experimentation. Understanding choices made by farmers in such experimentation processes is important to understand reasons why farmers in Tigray often hesitated to adopt recommended practices. Design/Methodology/Approach: A…

  5. Abstracts of the International seminar 'Experimental possibilities of KTM tokamak and research programme'

    International Nuclear Information System (INIS)

    2005-01-01

    The International seminar 'Experimental possibilities of KTM tokamak and research programme' was held in 10-12 October 2005 in Astana city (Kazakhstan). The seminar was dedicated to problems of KTM tokamak commissioning. The Collection of abstracts comprises 45 papers

  6. Experimental research of "microcable in a microconduct" system stability to effect of freezing water

    Science.gov (United States)

    Andreev, Vladimir A.; Burdin, Vladimir A.; Nikulina, Tatiana G.; Alekhin, Ivan N.; Gavryushin, Sergey A.; Nikulin, Aleksey G.; Praporshchikov, Denis E.

    2011-12-01

    Results of experimental researches of "optical microcable in a microduct" system stability to effect of freezing water are presented. It is shown this system is steadier to water freezing in comparison to lighten optical cable in protective polymer tube.

  7. Beyond post-marketing research and MedWatch: Long-term studies of drug risks.

    Science.gov (United States)

    Resnik, David B

    2007-10-01

    Critics of the drug safety system have discussed many different potential reforms, ranging from mandatory registration of clinical trials to increasing the power of regulatory agencies, but few have discussed one of the most important ways of enhancing safety: increasing the number of long-term studies of medications. Long-term studies of the risks and benefits of drugs can provide useful information for regulators, healthcare professionals, and patients. Government funding agencies should lead the effort to conduct long-term studies of drugs, but private companies should also be required to lend financial support. Because cost-effectiveness is likely to be an important consideration in conducting this research, funding agencies should focus, at first, on drugs that are used to treat common, chronic conditions.

  8. Transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma: its research progress

    International Nuclear Information System (INIS)

    Zhao Yan; Han Guohong; Bai Wei; Fan Daiming

    2012-01-01

    Transarterial chemoembolization (TACE) has been the main treatment for patients with intermediate-stage hepatocellular carcinoma (HCC). However, the clinical application of TACE is limited due to the technical deficiencies, such as uncontrolled local drug delivery and systemic toxicity. Recently, the new drug-eluting beads (DEB), loading with doxorubicin, have be used in the TACE procedures. This new technique can not only maintain the local drug level for quite a long time and thus get a higher objective response, but also decrease the systemic toxicity. Transarterial chemoembolization with drug-eluting beads (DEB-TACE) have already been widely used abroad, and more related clinical trials are underway to clarify its advantages. This paper aims to make a comprehensive review in the respects of its characteristics and the latest research progress in DEB-TACE. (authors)

  9. Ethics of animal research in human disease remediation, its institutional teaching; and alternatives to animal experimentation.

    Science.gov (United States)

    Cheluvappa, Rajkumar; Scowen, Paul; Eri, Rajaraman

    2017-08-01

    Animals have been used in research and teaching for a long time. However, clear ethical guidelines and pertinent legislation were instated only in the past few decades, even in developed countries with Judeo-Christian ethical roots. We compactly cover the basics of animal research ethics, ethical reviewing and compliance guidelines for animal experimentation across the developed world, "our" fundamentals of institutional animal research ethics teaching, and emerging alternatives to animal research. This treatise was meticulously constructed for scientists interested/involved in animal research. Herein, we discuss key animal ethics principles - Replacement/Reduction/Refinement. Despite similar undergirding principles across developed countries, ethical reviewing and compliance guidelines for animal experimentation vary. The chronology and evolution of mandatory institutional ethical reviewing of animal experimentation (in its pioneering nations) are summarised. This is followed by a concise rendition of the fundamentals of teaching animal research ethics in institutions. With the advent of newer methodologies in human cell-culturing, novel/emerging methods aim to minimise, if not avoid the usage of animals in experimentation. Relevant to this, we discuss key extant/emerging alternatives to animal use in research; including organs on chips, human-derived three-dimensional tissue models, human blood derivates, microdosing, and computer modelling of various hues. © 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

  10. A Bibliographic Study of Drug Abuse Research during last 30 years in Iran

    Directory of Open Access Journals (Sweden)

    Afarin Rahimi Movaghar

    2009-05-01

    Full Text Available In the last decades, the produced science has been significantly increased in the field of drug abuse, globally. The objective of this study was to assess the bibliographic aspects of the science produced in Iran on drug abuse in the last 30 years. All scientific papers published from Iran in a 30-year period (1973-2002 in national as well as international scientific journals were assessed for this study. These papers are indexed in the database for Iranian Mental Health Researches, called IranPsych. The total number of 218 papers on drug and drug abuse were found and assessed by six psychiatrists and psychologists with good inter-rater reliability. About half of these papers were published in the last two years. About half of the papers have been published in the Persian medical journals. One-third have been published in international journals. Overall, 449 authors contributed to the 218 published papers from whom 80 percent had only one paper. Half of the papers were written by only 15 authors (3.3 percent. Most of the authors were Medical Doctors and from Medical Universities. None of the researches was received financial support from pharmacologic industries. This study shows that in recent years, the increase in the publication of the researches conducted on drug abuse has been significant. Nevertheless, according to the high prevalence of drug abuse problem in Iran and improvements in the scientific, as well as executive structures, the whole scientific output is insignificant. The findings guide us to a more systematic approach toward training of researchers and promotion of resaerch in this area. Moreover, more active involvement of social scientists and publication of their research findings are recommended.

  11. Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.

    Science.gov (United States)

    Li, Ming; de Graaf, Inge A M; Groothuis, Geny M M

    2016-01-01

    The absorption, distribution, metabolism, excretion and toxicity (ADME-tox) processes of drugs are of importance and require preclinical investigation intestine in addition to the liver. Various models have been developed for prediction of ADME-tox in the intestine. In this review, precision-cut intestinal slices (PCIS) are discussed and highlighted as model for ADME-tox studies. This review provides an overview of the applications and an update of the most recent research on PCIS as an ex vivo model to study the transport, metabolism and toxicology of drugs and other xenobiotics. The unique features of PCIS and the differences with other models as well as the translational aspects are also discussed. PCIS are a simple, fast, and reliable ex vivo model for drug ADME-tox research. Therefore, PCIS are expected to become an indispensable link in the in vitro-ex vivo-in vivo extrapolation, and a bridge in translation of animal data to the human situation. In the future, this model may be helpful to study the effects of interorgan interactions, intestinal bacteria, excipients and drug formulations on the ADME-tox properties of drugs. The optimization of culture medium and the development of a (cryo)preservation technique require more research.

  12. Lifestyle Factors in Hypertension Drug Research: Systematic Analysis of Articles in a Leading Cochrane Report

    Directory of Open Access Journals (Sweden)

    Dan E. Wilson

    2014-01-01

    Full Text Available Established standards for first-line hypertension management include lifestyle modification and behavior change. The degree to which and how lifestyle modification is systematically integrated into studies of first-line drug management for hypertension is of methodological and clinical relevance. This study systematically reviewed the methodology of articles from a recent Cochrane review that had been designed to inform first-line medical treatment of hypertension and was representative of high quality established clinical trials in the field. Source articles (n=34 were systematically reviewed for lifestyle interventions including smoking cessation, diet, weight loss, physical activity and exercise, stress reduction, and moderate alcohol consumption. 54% of articles did not mention lifestyle modification; 46% contained nonspecific descriptions of interventions. We contend that hypertension management research trials (including drug studies need to elucidate the benefits and risks of drug-lifestyle interaction, to support the priority of lifestyle modification, and that lifestyle modification, rather than drugs, is seen by patients and the public as a priority for health professionals. The inclusion of lifestyle modification strategies in research designs for hypertension drug trials could enhance current research, from trial efficacy to clinical outcome effectiveness, and align hypertension best practices of a range of health professionals with evidence-based knowledge translation.

  13. Use of anonymous Web communities and websites by medical consumers in Japan to research drug information.

    Science.gov (United States)

    Kishimoto, Keiko; Fukushima, Noriko

    2011-01-01

    In this study, we investigated the status of researching drug information online, and the type of Internet user who uses anonymous Web communities and websites. A Web-based cross-sectional survey of 10875 male and female Internet users aged 16 and over was conducted in March 2010. Of 10282 analyzed respondents, excluding medical professionals, about 47% reported that they had previously searched the Internet for drug information and had used online resources ranging from drug information search engines and pharmaceutical industry websites to social networking sites and Twitter. Respondents who had researched drug information online (n=4861) were analyzed by two multivariable logistic regressions. In Model 1, the use of anonymous websites associated with age (OR, 0.778; 95% CI, 0.742-0.816), referring to the reputation and the narrative of other Internet users on shopping (OR, 1.640; 95% CI, 1.450-1.855), taking a prescription drug (OR, 0.806; 95% CI, 0.705-0.922), and frequent consulting with non-professionals about medical care and health (OR, 1.613; 95% CI, 1.396-1.865). In Model 2, use of only anonymous websites was associated with age (OR, 0.753; 95% CI, 0.705-0.805), using the Internet daily (OR, 0.611; 95% CI, 0.462-0.808), taking a prescription drug (OR, 0.614; 95% CI, 0.505-0.747), and experience a side effect (OR, 0.526; 95% CI, 0.421-0.658). The analysis revealed the profiles of Internet users who researched drug information on social media sites where the information providers are anonymous and do not necessarily have adequate knowledge of medicine and online information literacy.

  14. Research Costs Investigated: A Study Into the Budgets of Dutch Publicly Funded Drug-Related Research

    NARCIS (Netherlands)

    T. van Asselt (Thea); B.L.T. Ramaekers (Bram); I. Corro Ramos (Isaac); M.A. Joore (Manuela); M.J. Al (Maiwenn); Lesman-Leegte, I. (Ivonne); M.J. Postma (Maarten); P. Vemer (Pepijn); T.L. Feenstra (Talitha)

    2017-01-01

    textabstractBackground: The costs of performing research are an important input in value of information (VOI) analyses but are difficult to assess. Objective: The aim of this study was to investigate the costs of research, serving two purposes: (1) estimating research costs for use in VOI analyses;

  15. Research Costs Investigated : A Study Into the Budgets of Dutch Publicly Funded Drug-Related Research

    NARCIS (Netherlands)

    van Asselt, Thea; Ramaekers, Bram; Corro Ramos, Isaac; Joore, Manuela; Al, Maiwenn; Lesman-Leegte, Ivonne; Postma, Maarten; Vemer, Pepijn; Feenstra, Talitha

    BACKGROUND: The costs of performing research are an important input in value of information (VOI) analyses but are difficult to assess. OBJECTIVE: The aim of this study was to investigate the costs of research, serving two purposes: (1) estimating research costs for use in VOI analyses; and (2)

  16. Institutional ethical review and ethnographic research involving injection drug users: a case study.

    Science.gov (United States)

    Small, Will; Maher, Lisa; Kerr, Thomas

    2014-03-01

    Ethnographic research among people who inject drugs (PWID) involves complex ethical issues. While ethical review frameworks have been critiqued by social scientists, there is a lack of social science research examining institutional ethical review processes, particularly in relation to ethnographic work. This case study describes the institutional ethical review of an ethnographic research project using observational fieldwork and in-depth interviews to examine injection drug use. The review process and the salient concerns of the review committee are recounted, and the investigators' responses to the committee's concerns and requests are described to illustrate how key issues were resolved. The review committee expressed concerns regarding researcher safety when conducting fieldwork, and the investigators were asked to liaise with the police regarding the proposed research. An ongoing dialogue with the institutional review committee regarding researcher safety and autonomy from police involvement, as well as formal consultation with a local drug user group and solicitation of opinions from external experts, helped to resolve these issues. This case study suggests that ethical review processes can be particularly challenging for ethnographic projects focused on illegal behaviours, and that while some challenges could be mediated by modifying existing ethical review procedures, there is a need for legislation that provides legal protection of research data and participant confidentiality. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. RESEARCH OF CONDITION OF PUBLIC DRUG ASSISTANCE DURING INDEPENDENCE YEARS OF UKRAINE - FORMATION OF PHARMACEUTICAL MARKET

    Directory of Open Access Journals (Sweden)

    V. O. Boryshchuk

    2015-10-01

    Full Text Available The aim of the research was to study the correspondence of existing legislative and regulatory requirements of the pharmaceutical industry development, the analysis of the formation of the Ukrainian pharmaceutical market, the condition of drug assistance according to European requirements and recommendations of the WHO. For the study archival materials, publications in scientific journals, and mass media were used, laws and provisions regulating pharmaceutical activity were studied and a survey among citizens was conducted. Systematic and logical methods, analytical and comparative analysis were applied, and own researches were performed. For 22 years of Ukrainian statehood formation the following institutes were created: Pharmacological College, Pharmacopoeia Committee and State Service for Quality Control of Drugs which were transported to other institutes. Important laws were adopted: the Law of Ukraine «On Medicines», the Law of Ukraine «On small-scale privatization», the Law of Ukraine «On large-scale privatization» and others, which contributed to the formation and development of the pharmaceutical market. In comparison with 1990 the amount of drugstore chains increased two and a half times and in 2013 in the country already worked 15 566 drugstores, including 3 025 in villages. Specific peculiarity of pharmaceutical market formation in Ukraine was the creation of powerful own regional and all-Ukrainian drugstore chains, that is greatly different from such situation in EU countries, where the legislation allows to have only one or two drugstores. As the result of pharmaceutical market formation the drugs nomenclature increased eight times and now makes up more than 20 000 names, including 92.4 % generic drugs. According to publications, Ukraine lacks about 40 % of drug molecules needed for medical treatment, and 30 % of studied drugs are not proved. There is the problem of uncontrollable turnover and drugs consumption in Ukraine

  18. Effective experimental tumor therapy with targeted polymer drug delivery systems based on HPMA copolymers.

    Czech Academy of Sciences Publication Activity Database

    Šírová, Milada; Horková, Veronika; Sivák, Ladislav; Etrych, Tomáš; Říhová, Blanka; Studenovský, Martin

    SI (2016), s. 24-24 ISSN 0014-2980. [3rd Meeting of Middle – European Societies for Immunology and Allergology. 01.12.2016-03.12.2016, Budapest ] R&D Projects: GA ČR(CZ) GA14-12742S Institutional support: RVO:61388971 ; RVO:61389013 Keywords : Tumor therapy * polymer drug * HPMA copolymers Subject RIV: EE - Microbiology, Virology

  19. Drug-induced Hypothermia by 5HT1A Agonists Provide Neuroprotection in Experimental Stroke

    DEFF Research Database (Denmark)

    Johansen, Flemming Fryd; Hasseldam, Henrik; Nybro Smith, Matthias

    2014-01-01

    BACKGROUND: Drug-induced hypothermia reduces brain damage in animal stroke models and is an undiscovered potential in human stroke treatment. We studied hypothermia induced by the serotonergic agonists S14671 (1-[2-(2-thenoylamino)ethyl]-4[1-(7- methoxynaphtyl)]piperazine) and ipsapirone in a rat...... therapeutic hypothermia....

  20. Drug-eluting stents: from bench-top to clinical research

    NARCIS (Netherlands)

    Basalus, Mounir Welson Zakhary

    2013-01-01

    The development of drug-eluting stents (DES) has improved the invasive treatment of obstructive coronary artery disease by reducing both, restenosis rate and need for reinterventions. This success resulted in a widespread utilization of DES in clinical practice and entailed many clinical research

  1. Review on research of suppression male fertility and male contraceptive drug development by natural products.

    Science.gov (United States)

    Bajaj, Vijay Kumar; Gupta, Radhey S

    2013-08-01

    Male contraceptive development in the present scenario is most viable aspect of research due to uncontrolled population growth in the world. In this respect investigators are busy to find out a safe male contraceptive drug. Researchers have started their finding for a suitable drug from natural sources because these are safe and easily acceptable for common man, most of natural sources are plants and their products. In this review 137 plants and their effects on reproduction and reproductive physiology are summarized. Some of them have intense effect on male reproductive system and do not produce any side effects. Reproductive toxicological studies are also important aspects of these kinds of researches, so it is important that drugs are safe and widely acceptable. An ideal male contraceptive can influence semen, testes, hormone level, accessory reproductive organs and general physiology of animals and produced some alterations. Many plants in this review are showing antifertility as well as antispermatogenic effects, so these may be used for further study for contraceptives development but it is important to find out the mechanism of reaction and further laboratory and clinical research on some plants are needed for final male contraceptive drug development. In conclusion this review will help for finding suitable plant products for male contraceptive clinical and laboratory studies.

  2. Alcohol and Other Drug Use: The Connection to Youth Suicide. Abstracts of Selected Research.

    Science.gov (United States)

    Laws, Kathy; Turner, Amy

    This publication provides the reader with an overview of the research done on the connection between the use of alcohol and other drugs and the ideation and/or completion of suicide among adolescents. It also provides information and resources on how to develop a youth suicide prevention program. The introduction gives a brief overview of the…

  3. Cryopreservation of Precision-cut Tissue Slices for Application in Drug Metabolism Research

    NARCIS (Netherlands)

    Graaf, Inge Anne Maria de

    2002-01-01

    The research described in this thesis had two important aims. The first was to determine whether tissue slices could be used as an in vitro tool to predict the in vivo metabolism of new drugs. The second aim was to find a manner to store tissue slices for longer time periods by cryopreservation.

  4. Mass Spectrometry for Research and Application in Therapeutic Drug Monitoring or Clinical and Forensic Toxicology.

    Science.gov (United States)

    Maurer, Hans H

    2018-04-30

    This paper reviews current applications of various hyphenated low- and high-resolution mass spectrometry techniques in the field of therapeutic drug monitoring and clinical/forensic toxicology in both research and practice. They cover gas chromatography, liquid chromatography, matrix-assisted laser desorption ionization, or paper spray ionization coupled to quadrupole, ion trap, time-of-flight, or Orbitrap mass analyzers.

  5. Scaling Up Research on Drug Abuse and Addiction Through Social Media Big Data.

    Science.gov (United States)

    Kim, Sunny Jung; Marsch, Lisa A; Hancock, Jeffrey T; Das, Amarendra K

    2017-10-31

    Substance use-related communication for drug use promotion and its prevention is widely prevalent on social media. Social media big data involve naturally occurring communication phenomena that are observable through social media platforms, which can be used in computational or scalable solutions to generate data-driven inferences. Despite the promising potential to utilize social media big data to monitor and treat substance use problems, the characteristics, mechanisms, and outcomes of substance use-related communications on social media are largely unknown. Understanding these aspects can help researchers effectively leverage social media big data and platforms for observation and health communication outreach for people with substance use problems. The objective of this critical review was to determine how social media big data can be used to understand communication and behavioral patterns of problematic use of prescription drugs. We elaborate on theoretical applications, ethical challenges and methodological considerations when using social media big data for research on drug abuse and addiction. Based on a critical review process, we propose a typology with key initiatives to address the knowledge gap in the use of social media for research on prescription drug abuse and addiction. First, we provided a narrative summary of the literature on drug use-related communication on social media. We also examined ethical considerations in the research processes of (1) social media big data mining, (2) subgroup or follow-up investigation, and (3) dissemination of social media data-driven findings. To develop a critical review-based typology, we searched the PubMed database and the entire e-collection theme of "infodemiology and infoveillance" in the Journal of Medical Internet Research / JMIR Publications. Studies that met our inclusion criteria (eg, use of social media data concerning non-medical use of prescription drugs, data informatics-driven findings) were

  6. Illegal Drugs Laws: Clearing a 50-Year-Old Obstacle to Research

    Science.gov (United States)

    Nutt, David

    2015-01-01

    The United Nations drug control conventions of 1960 and 1971 and later additions have inadvertently resulted in perhaps the greatest restrictions of medical and life sciences research. These conventions now need to be revised to allow neuroscience to progress unimpeded and to assist in the innovation of treatments for brain disorders. In the meantime, local changes, such as the United Kingdom moving cannabis from Schedule 1 to Schedule 2, should be implemented to allow medical research to develop appropriately. PMID:25625189

  7. Illegal drugs laws: clearing a 50-year-old obstacle to research.

    Directory of Open Access Journals (Sweden)

    David Nutt

    2015-01-01

    Full Text Available The United Nations drug control conventions of 1960 and 1971 and later additions have inadvertently resulted in perhaps the greatest restrictions of medical and life sciences research. These conventions now need to be revised to allow neuroscience to progress unimpeded and to assist in the innovation of treatments for brain disorders. In the meantime, local changes, such as the United Kingdom moving cannabis from Schedule 1 to Schedule 2, should be implemented to allow medical research to develop appropriately.

  8. Illegal drugs laws: clearing a 50-year-old obstacle to research.

    Science.gov (United States)

    Nutt, David

    2015-01-01

    The United Nations drug control conventions of 1960 and 1971 and later additions have inadvertently resulted in perhaps the greatest restrictions of medical and life sciences research. These conventions now need to be revised to allow neuroscience to progress unimpeded and to assist in the innovation of treatments for brain disorders. In the meantime, local changes, such as the United Kingdom moving cannabis from Schedule 1 to Schedule 2, should be implemented to allow medical research to develop appropriately.

  9. Research as an event: a novel approach to promote patient-focused drug development

    Directory of Open Access Journals (Sweden)

    Tsai JH

    2018-05-01

    Full Text Available Jui-Hua Tsai, Ellen Janssen, John FP Bridges Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Abstract: Patient groups are increasingly engaging in research to understand patients’ preferences and incorporate their perspectives into drug development and regulation. Several models of patient engagement have emerged, but there is little guidance on how to partner with patient groups to engage the disease community. Our group has been using an approach to engage patient groups that we call research as an event. Research as an event is a method for researchers to use a community-centered event to engage patients in their own environment at modest incremental cost. It is a pragmatic solution to address the challenges of engaging patients in research to minimize patients’ frustration, decrease the time burden, and limit the overall cost. The community, the event, and the research are the three components that constitute the research as an event framework. The community represents a disease-specific community. The event is a meeting of common interest for patients and other stakeholders, such as a patient advocacy conference. The research describes activities in engaging the community for the purpose of research. Research as an event follows a six-step approach. A case study is used to demonstrate the six steps followed by recommendations for future implementation. Keywords: patients’ perspectives, decision making, drug approval, patient engagement, patient organization, patients’ preference

  10. Six-Month Market Exclusivity Extensions To Promote Research Offer Substantial Returns For Many Drug Makers.

    Science.gov (United States)

    Kesselheim, Aaron S; Rome, Benjamin N; Sarpatwari, Ameet; Avorn, Jerry

    2017-02-01

    To incentivize pharmaceutical manufacturers to invest in areas of unmet medical need, policy makers frequently propose extending the market exclusivity period of desired drugs. Some such proposals are modeled after the pediatric exclusivity patent extension program, which since 1997 has provided six additional months of market exclusivity for drugs studied in children. The most recent proposal would encourage rare disease research by providing six months of extended exclusivity for any existing drug that is granted subsequent FDA approval for a new rare disease indication. Yet the economic impact of such proposals is rarely addressed. We found that for the thirteen FDA-approved drugs that gained supplemental approval for a rare disease indication from 2005 through 2010, the median projected cost of clinical trials leading to approval was $29.8 million. If the exclusivity extension had been in place, the median discounted financial gain to manufacturers would have been $94.6 million. Median net returns would have been $82.4 million, with higher returns for drugs with higher annual sales. Extending market exclusivity would provide substantial compensation to many manufacturers, particularly for top-selling products, far in excess of the cost of conducting these trials. Alternative strategies to incentivize the study of approved drugs for rare diseases may offer similar benefits at a lower cost. Project HOPE—The People-to-People Health Foundation, Inc.

  11. An exploratory research on the role of family in youth's drug addiction.

    Science.gov (United States)

    Masood, Sobia; Us Sahar, Najam

    2014-01-01

    Most of the researches in Pakistan are concerned with the aetiological factors of drug addiction among the youth. However, few studies seek to explore the social aspects of this phenomenon. The present study aimed to explore the role of family, the influence of parental involvement, and communication styles in youth's drug addiction in a qualitative manner. Twenty drug addicts (age range 18-28 years) were taken as a sample from drug rehabilitation centres in Rawalpindi and Islamabad, Pakistan. A structured interview guide was administered comprising questions related to the individual's habits, relationship with family and friends, and modes of communication within the family. Case profiles of the participants were also taken. The rehabilitation centres offered family therapy and the researcher, as a non-participant, observed these sessions as part of the analysis. The demographic information revealed that majority of the participants were poly-substance abusers (80%) and the significant reasons for starting drugs were the company of peers and curiosity. The thematic analysis revealed parental involvement and emotional expressiveness as two major components in family communication. It was found that parents were concerned about their children, but were not assertive in the implementation of family rules. It was also found that the major life decisions of the participants were taken by their parents, which is a characteristic of collectivist Pakistani society.

  12. A practical approach to risk-benefit estimation in pediatric drug research.

    Science.gov (United States)

    Koren, Gideon

    2015-02-01

    One of the most difficult challenges in pediatric drug research is in exposing children to risk, often without a balanced chance of benefits. While the concept of risk is similar in adult research, the adult patient can decide for himself/herself on an acceptable level of risk, whereas children have to accept the decisions of their guardians. This paper attempts to put the complexities of estimating risk in pediatric drug research into their practical perspective, and to familiarize the reader with the way such processes are conducted in different parts of the world. Although there are regional differences, all authorities typically quantify risks of pediatric research in general, and drug research in particular, in three levels: those experienced in day-to-day life; risks slightly above this 'baseline' risk; and risks substantially above 'baseline risk'. Proportionally, the diligence of the ethics process depends on these levels, as well as on the potential benefits (or lack of) to the child involved in the research. Importantly, risk is context dependent, and a particular intervention may be effective or safe in one setting but not in another, based on local experience, staffing levels, and similar variabilities.

  13. Evolution of soil, ecosystem, and critical zone research at the USDA FS Calhoun Experimental Forest

    Science.gov (United States)

    Daniel deB. Richter; Allan R. Bacon; Sharon A. Billings; Dan Binkley; Marilyn Buford; Mac Callaham; Amy E. Curry; Ryan L. Fimmen; A. Stuart Grandy; Paul R. Heine; Michael Hofmockel; Jason A. Jackson; Elisabeth LeMaster; Jianwei Li; Daniel Markewitz; Megan L. Mobley; Mary W. Morrison; Michael S. Strickland; Thomas Waldrop; Carol G. Wells

    2015-01-01

    The US Department of Agriculture (USDA) Forest Service Calhoun Experimental Forest was organized in 1947 on the southern Piedmont to engage in research that today is called restoration ecology, to improve soils, forests, and watersheds in a region that had been severely degraded by nearly 150 years farming. Today, this 2,050-ha research forest is managed by the Sumter...

  14. Louisiana’s Palustris Experimental Forest: 75 years of research that transformed the South

    Science.gov (United States)

    James P. Barnett; James D. Haywood; Henry A. Pearson

    2011-01-01

    The Palustris Experimental Forest, located on Kisatchie National Forest, has been in existence for 75 years. Research at Palustris has focused on southern pine reforestation technology, including seed production, bareroot nursery production, direct seeding, and planting container seedlings. After establishing pine plantations, researchers developed stand management...

  15. Personal Reflections on Observational and Experimental Research Approaches to Childhood Psychopathology

    Science.gov (United States)

    Rapoport, Judith L.

    2009-01-01

    The past 50 years have seen dramatic changes in childhood psychopathology research. The goal of this overview is to contrast observational and experimental research approaches; both have grown more complex such that the boundary between these approaches may be blurred. Both are essential. Landmark observational studies with long-term follow-up…

  16. EXPERIMENTAL RESEARCHES OF THERMO-PHYSICAL AND PHYSICOCHEMICAL INTERNALS OF BIO-DIESEL FUEL

    OpenAIRE

    V. N. Goryachkin; A. V. Ivaschenko

    2010-01-01

    The conducted researches are related to transfer of diesel engines to biodiesel fuel. The technique and results of an experimental research of thermo-physical and physical-and-chemical properties of biodiesel fuel as well as mixes of biodiesel fuel with the petroleum one are presented.

  17. EXPERIMENTAL RESEARCHES OF THERMO-PHYSICAL AND PHYSICOCHEMICAL INTERNALS OF BIO-DIESEL FUEL

    Directory of Open Access Journals (Sweden)

    V. N. Goryachkin

    2010-11-01

    Full Text Available The conducted researches are related to transfer of diesel engines to biodiesel fuel. The technique and results of an experimental research of thermo-physical and physical-and-chemical properties of biodiesel fuel as well as mixes of biodiesel fuel with the petroleum one are presented.

  18. Scaling Up Research on Drug Abuse and Addiction Through Social Media Big Data

    Science.gov (United States)

    Marsch, Lisa A; Hancock, Jeffrey T; Das, Amarendra K

    2017-01-01

    Background Substance use–related communication for drug use promotion and its prevention is widely prevalent on social media. Social media big data involve naturally occurring communication phenomena that are observable through social media platforms, which can be used in computational or scalable solutions to generate data-driven inferences. Despite the promising potential to utilize social media big data to monitor and treat substance use problems, the characteristics, mechanisms, and outcomes of substance use–related communications on social media are largely unknown. Understanding these aspects can help researchers effectively leverage social media big data and platforms for observation and health communication outreach for people with substance use problems. Objective The objective of this critical review was to determine how social media big data can be used to understand communication and behavioral patterns of problematic use of prescription drugs. We elaborate on theoretical applications, ethical challenges and methodological considerations when using social media big data for research on drug abuse and addiction. Based on a critical review process, we propose a typology with key initiatives to address the knowledge gap in the use of social media for research on prescription drug abuse and addiction. Methods First, we provided a narrative summary of the literature on drug use–related communication on social media. We also examined ethical considerations in the research processes of (1) social media big data mining, (2) subgroup or follow-up investigation, and (3) dissemination of social media data-driven findings. To develop a critical review-based typology, we searched the PubMed database and the entire e-collection theme of “infodemiology and infoveillance” in the Journal of Medical Internet Research / JMIR Publications. Studies that met our inclusion criteria (eg, use of social media data concerning non-medical use of prescription drugs, data

  19. Incentives for orphan drug research and development in the United States.

    Science.gov (United States)

    Seoane-Vazquez, Enrique; Rodriguez-Monguio, Rosa; Szeinbach, Sheryl L; Visaria, Jay

    2008-12-16

    The Orphan Drug Act (1983) established several incentives to encourage the development of orphan drugs (ODs) to treat rare diseases and conditions. This study analyzed the characteristics of OD designations, approvals, sponsors, and evaluated the effective patent and market exclusivity life of orphan new molecular entities (NMEs) approved in the US between 1983 and 2007. Primary data sources were the FDA Orange Book, the FDA Office of Orphan Drugs Development, and the US Patent and Trademark Office. Data included all orphan designations and approvals listed by the FDA and all NMEs approved by the FDA during the study period. The FDA listed 1,793 orphan designations and 322 approvals between 1983 and 2007. Cancer was the main group of diseases targeted for orphan approvals. Eighty-three companies concentrated 67.7% of the total orphan NMEs approvals. The average time from orphan designation to FDA approval was 4.0 +/- 3.3 years (mean +/- standard deviation). The average maximum effective patent and market exclusivity life was 11.7 +/- 5.0 years for orphan NME. OD market exclusivity increased the average maximum effective patent and market exclusivity life of ODs by 0.8 years. Public programs, federal regulations, and policies support orphan drugs R&D. Grants, research design support, FDA fee waivers, tax incentives, and orphan drug market exclusivity are the main incentives for orphan drug R&D. Although the 7-year orphan drug market exclusivity provision had a positive yet relatively modest overall effect on effective patent and market exclusivity life, economic incentives and public support mechanisms provide a platform for continued orphan drug development for a highly specialized market.

  20. Volcanic Experimentation: Using Mentos and Soda to Teach Causal Research in a Marketing Research Class

    Science.gov (United States)

    Love, Edwin; Stelling, Pete

    2012-01-01

    The reaction that occurs when Mentos are added to bottled soft drinks has become a staple demonstration in earth science courses to explain how volcanoes erupt. This paper presents how this engaging exercise can be used in a marketing research course to provide hands-on experience with problem formation, hypothesis testing, and causal research. A…

  1. Accomplishments of LOCA/ECCS experimental research at Japan Atomic Energy Research Institute

    International Nuclear Information System (INIS)

    Tasaka, Kanji; Murao, Yoshio; Koizumi, Yasuo

    1984-01-01

    Japan Atomic Energy Research Institute has investigated loss-of-coolant accident (LOCA)/emergency core cooling system (ECCS) from 1970. Major results of the LOCA/ECCS research are summarized in this report. ROSA-II program was LOCA/ECCS research for a pressurized water reactor (PWR) and ROSA-III program was for a boiling water reactor (BWR). The both test facilities were scaled at approximately 1/400 of the respective reference PWR and BWR. Large scale reflood test is research on reflood phenomena during a large break LOCA of PWR. The test facility is scaled at approximately 1/20 of the reference PWR and the research is still being continued. (author)

  2. A novel experimental design method to optimize hydrophilic matrix formulations with drug release profiles and mechanical properties.

    Science.gov (United States)

    Choi, Du Hyung; Lim, Jun Yeul; Shin, Sangmun; Choi, Won Jun; Jeong, Seong Hoon; Lee, Sangkil

    2014-10-01

    To investigate the effects of hydrophilic polymers on the matrix system, an experimental design method was developed to integrate response surface methodology and the time series modeling. Moreover, the relationships among polymers on the matrix system were studied with the evaluation of physical properties including water uptake, mass loss, diffusion, and gelling index. A mixture simplex lattice design was proposed while considering eight input control factors: Polyethylene glycol 6000 (x1 ), polyethylene oxide (PEO) N-10 (x2 ), PEO 301 (x3 ), PEO coagulant (x4 ), PEO 303 (x5 ), hydroxypropyl methylcellulose (HPMC) 100SR (x6 ), HPMC 4000SR (x7 ), and HPMC 10(5) SR (x8 ). With the modeling, optimal formulations were obtained depending on the four types of targets. The optimal formulations showed the four significant factors (x1 , x2 , x3 , and x8 ) and other four input factors (x4 , x5 , x6 , and x7 ) were not significant based on drug release profiles. Moreover, the optimization results were analyzed with estimated values, targets values, absolute biases, and relative biases based on observed times for the drug release rates with four different targets. The result showed that optimal solutions and target values had consistent patterns with small biases. On the basis of the physical properties of the optimal solutions, the type and ratio of the hydrophilic polymer and the relationships between polymers significantly influenced the physical properties of the system and drug release. This experimental design method is very useful in formulating a matrix system with optimal drug release. Moreover, it can distinctly confirm the relationships between excipients and the effects on the system with extensive and intensive evaluations. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  3. Experimental Methods and Transport Models for Drug Delivery across the Blood-Brain Barrier

    OpenAIRE

    Fu, Bingmei M

    2012-01-01

    The blood-brain barrier (BBB) is a dynamic barrier essential for maintaining the micro-environment of the brain. Although the special anatomical features of the BBB determine its protective role for the central nervous system (CNS) from blood-born neurotoxins, however, the BBB extremely limits the therapeutic efficacy of drugs into the CNS, which greatly hinders the treatment of major brain diseases. This review summarized the unique structures of the BBB, described a variety of in vivo and i...

  4. Conceptualizing ethnicity in alcohol and drug research: Epidemiology meets social theory.

    Science.gov (United States)

    Hunt, Geoffrey; Kolind, Torsten; Antin, Tamar

    2018-01-01

    Since the 1990s, social scientists have rejected notions of ethnicity as something static and discrete, instead highlighting the context-dependent and fluid nature of multiple identities. In spite of these developments, researchers within the substance use fields continue to assess ethnic group categories in ways that suggest little critical reflection in terms of the validity of the measurements themselves, nor the social, bureaucratic, and political decisions shaping standard measures of ethnicity. This paper highlights these considerations, while also acknowledging the role of socially-delineated ethnic categorizations in documenting health inequities and social injustices. We call on researchers in alcohol and drugs research to critically appraise their use of ethnic categorizations, querying how to best measure ethnicity within their own studies in ways that are justified beyond simplified explanations of social convention and that "do no harm" in terms of perpetuating racism and obscuring the roots causes of social and health problems related to alcohol and drugs.

  5. Experimental psychopathology paradigms for alcohol use disorders: Applications for translational research.

    Science.gov (United States)

    Bujarski, Spencer; Ray, Lara A

    2016-11-01

    In spite of high prevalence and disease burden, scientific consensus on the etiology and treatment of Alcohol Use Disorder (AUD) has yet to be reached. The development and utilization of experimental psychopathology paradigms in the human laboratory represents a cornerstone of AUD research. In this review, we describe and critically evaluate the major experimental psychopathology paradigms developed for AUD, with an emphasis on their implications, strengths, weaknesses, and methodological considerations. Specifically we review alcohol administration, self-administration, cue-reactivity, and stress-reactivity paradigms. We also provide an introduction to the application of experimental psychopathology methods to translational research including genetics, neuroimaging, pharmacological and behavioral treatment development, and translational science. Through refining and manipulating key phenotypes of interest, these experimental paradigms have the potential to elucidate AUD etiological factors, improve the efficiency of treatment developments, and refine treatment targets thus advancing precision medicine. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Understanding the physical and chemical nature of the warfarin drug binding site in human serum albumin: experimental and theoretical studies.

    Science.gov (United States)

    Abou-Zied, Osama K

    2015-01-01

    Human serum albumin (HSA) is one of the major carrier proteins in the body and constitutes approximately half of the protein found in blood plasma. It plays an important role in lipid metabolism, and its ability to reversibly bind a large variety of pharmaceutical compounds makes it a crucial determinant of drug pharmacokinetics and pharmacodynamics. This review deals with one of the protein's major binding sites "Sudlow I" which includes a binding pocket for the drug warfarin (WAR). The binding nature of this important site can be characterized by measuring the spectroscopic changes when a ligand is bound. Using several drugs, including WAR, and other drug-like molecules as ligands, the results emphasize the nature of Sudlow I as a flexible binding site, capable of binding a variety of ligands by adapting its binding pockets. The high affinity of the WAR pocket for binding versatile molecular structures stems from the flexibility of the amino acids forming the pocket. The binding site is shown to have an ionization ability which is important to consider when using drugs that are known to bind in Sudlow I. Several studies point to the important role of water molecules trapped inside the binding site in molecular recognition and ligand binding. Water inside the protein's cavity is crucial in maintaining the balance between the hydrophobic and hydrophilic nature of the binding site. Upon the unfolding and refolding of HSA, more water molecules are trapped inside the binding site which cause some swelling that prevents a full recovery from the denatured state. Better understanding of the mechanism of binding in macromolecules such as HSA and other proteins can be achieved by combining experimental and theoretical studies which produce significant synergies in studying complex biochemical phenomena.

  7. A statistical experimental design approach to evaluate the influence of various penetration enhancers on transdermal drug delivery of buprenorphine

    Directory of Open Access Journals (Sweden)

    S.Mojtaba Taghizadeh

    2015-03-01

    Full Text Available A series of drug-in-adhesive transdermal drug delivery systems (patch with different chemical penetration enhancers were designed to deliver drug through the skin as a site of application. The objective of our effort was to study the influence of various chemical penetration enhancers on skin permeation rate and adhesion properties of a transdermal drug delivery system using Box–Behnken experimental design. The response surface methodology based on a three-level, three-variable Box–Behnken design was used to evaluate the interactive effects on dependent variables including, the rate of skin permeation and adhesion properties, namely peel strength and tack value. Levulinic acid, lauryl alcohol, and Tween 80 were used as penetration enhancers (patch formulations, containing 0–8% of each chemical penetration enhancer. Buprenorphine was used as a model penetrant drug. The results showed that incorporation of 20% chemical penetration enhancer into the mixture led to maximum skin permeation flux of buprenorphine from abdominal rat skin while the adhesion properties decreased. Also that skin flux in presence of levulinic acid (1.594 μg/cm2 h was higher than Tween 80 (1.473 μg/cm2 h and lauryl alcohol (0.843 μg/cm2 h, and in mixing these enhancers together, an additional effect was observed. Moreover, it was found that each enhancer increased the tack value, while levulinic acid and lauryl alcohol improved the peel strength but Tween 80 reduced it. These findings indicated that the best chemical skin penetration enhancer for buprenorphine patch was levulinic acid. Among the designed formulations, the one which contained 12% (wt/wt enhancers exhibited the highest efficiency.

  8. A statistical experimental design approach to evaluate the influence of various penetration enhancers on transdermal drug delivery of buprenorphine.

    Science.gov (United States)

    Taghizadeh, S Mojtaba; Moghimi-Ardakani, Ali; Mohamadnia, Fatemeh

    2015-03-01

    A series of drug-in-adhesive transdermal drug delivery systems (patch) with different chemical penetration enhancers were designed to deliver drug through the skin as a site of application. The objective of our effort was to study the influence of various chemical penetration enhancers on skin permeation rate and adhesion properties of a transdermal drug delivery system using Box-Behnken experimental design. The response surface methodology based on a three-level, three-variable Box-Behnken design was used to evaluate the interactive effects on dependent variables including, the rate of skin permeation and adhesion properties, namely peel strength and tack value. Levulinic acid, lauryl alcohol, and Tween 80 were used as penetration enhancers (patch formulations, containing 0-8% of each chemical penetration enhancer). Buprenorphine was used as a model penetrant drug. The results showed that incorporation of 20% chemical penetration enhancer into the mixture led to maximum skin permeation flux of buprenorphine from abdominal rat skin while the adhesion properties decreased. Also that skin flux in presence of levulinic acid (1.594 μg/cm(2) h) was higher than Tween 80 (1.473 μg/cm(2) h) and lauryl alcohol (0.843 μg/cm(2) h), and in mixing these enhancers together, an additional effect was observed. Moreover, it was found that each enhancer increased the tack value, while levulinic acid and lauryl alcohol improved the peel strength but Tween 80 reduced it. These findings indicated that the best chemical skin penetration enhancer for buprenorphine patch was levulinic acid. Among the designed formulations, the one which contained 12% (wt/wt) enhancers exhibited the highest efficiency.

  9. Previniendo el Uso de Drogas entre Ninos y Adolescentes: Una Guia Basada en Investigaciones (Preventing Drug Use among Children and Adolescents: A Research-Based Guide).

    Science.gov (United States)

    Sloboda, Zili; David, Susan L.

    This question and answer guide provides an overview of the research on the origins and pathways of drug abuse, the basic principles derived from effective drug abuse prevention research, and the application of research results to the prevention of drug use among young people. The basic principles derived from drug abuse prevention research are…

  10. Use of comparative effectiveness research in drug coverage and pricing decisions: a six-country comparison.

    Science.gov (United States)

    Sorenson, Corinna

    2010-07-01

    Comparative effectiveness research (CER) has assumed an increasing role in drug coverage and, in some cases, pricing decisions in Europe, as decision-makers seek to obtain better value for money. This issue brief comparatively examines the use of CER across six countries--Denmark, England, France, Germany, the Netherlands, and Sweden. With CER gaining traction in the United States, these international experiences offer insights and potential lessons. Investing in CER can help address the current gap in publicly available, credible, up-to-date, and scientifically based comparative information on the effectiveness of drugs and other health interventions. This information can be used to base coverage and pricing decisions on evidence of value, thereby facilitating access to and public and private investment in the most beneficial new drugs and technologies. In turn, use of CER creates incentives for more efficient, high-quality health care and encourages development of innovative products that offer measurable value to patients.

  11. Experimental research and numerical simulation on flow resistance of integrated valve

    International Nuclear Information System (INIS)

    Cai Wei; Bo Hanliang; Qin Benke

    2008-01-01

    The flow resistance of the integrated valve is one of the key parameters for the design of the control rod hydraulic drive system (CRHDS). Experimental research on the improved new integrated valve was performed, and the key data such as pressure difference, volume flow, resistance coefficient and flow coefficient of each flow channel were obtained. With the computational fluid dynamics software CFX, numerical simulation was executed to analyze the effect of Re on the flow resistance. On the basis of experimental and numerical results, fitting empirical formulas of resistance coefficient were obtained, which provide experimental and theoretical foundations for CRHDS's optimized design and theoretical analysis. (authors)

  12. Drug-resistant tuberculosis in Mumbai, India: An agenda for operations research

    Science.gov (United States)

    Mistry, Nerges; Tolani, Monica; Osrin, David

    2012-01-01

    Operations research (OR) is well established in India and is also a prominent feature of the global and local agendas for tuberculosis (TB) control. India accounts for a quarter of the global burden of TB and of new cases. Multidrug-resistant TB is a significant problem in Mumbai, India’s most populous city, and there have been recent reports of totally resistant TB. Much thought has been given to the role of OR in addressing programmatic challenges, by both international partnerships and India’s Revised National TB Control Programme. We attempt to summarize the major challenges to TB control in Mumbai, with an emphasis on drug resistance. Specific challenges include diagnosis of TB and defining cure, detecting drug resistant TB, multiple sources of health care in the private, public and informal sectors, co-infection with human immunodeficiency virus (HIV) and a concurrent epidemic of non-communicable diseases, suboptimal prescribing practices, and infection control. We propose a local agenda for OR: modeling the effects of newer technologies, active case detection, and changes in timing of activities, and mapping hotspots and contact networks; modeling the effects of drug control, changing the balance of ambulatory and inpatient care, and adverse drug reactions; modeling the effects of integration of TB and HIV diagnosis and management, and preventive drug therapy; and modeling the effects of initiatives to improve infection control. PMID:24501697

  13. Experimental and calculational works on characteristics of the Dalat Nuclear Research Reactor. Second edition

    International Nuclear Information System (INIS)

    Pham Ngoc Khoi; Nguyen Kim Dung

    2016-03-01

    Recognizing the significant value and necessity of publishing the scientific document of experimental and calculational works on the Dalat Nuclear Research Reactor (DNRR) physics and engineering for research, operation, training activities as well as for international scientific exchange, Vietnam Atomic Energy Agency (VAEA) and Vietnam Atomic Energy Institute have completed editing to publish the “Experimental and Calculational Works on Characteristics of THE DALAT NUCLEAR RESEARCH REACTOR” which consists of 26 typical papers representing the most important experimental and calculational results of the DNRR physics and engineering obtained during 30 years of operation and exploitation with the contribution of Vietnamese and former USSR’s experts, especially scientists and engineers working at the Reactor Center of the NRI

  14. Theoretical and Experimental Research Performed on the Tesla Turbine - Part I

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu

    2015-09-01

    Full Text Available The paper presents the theoretical and experimental research performed on a Tesla turbine driven by compressed air and designed to equip a teaching laboratory [1], [2]. It introduces the operating principle of the Tesla turbine, which was invented by engineer Nikola Tesla, a turbine which uses discs instead of blades, mounted on a shaft at a small distance between them. The turbine geometry, results from stress and flow calculations performed on the turbine rotor and assembly, using the Simulation modules and SolidWorks Flow Simulation program are presented. After designing the turbine, it becomes the subject of experimental research to determine the curve of the speed depending on the pressure. Also, the experimental research focuses on the behaviour of the turbine from a dynamic point of view [3].

  15. To Support Research Activities Under the NASA Experimental Program to Stimulate Competitive Research

    Science.gov (United States)

    Gregory, John C.

    2003-01-01

    The Alabama NASA EPSCoR Program is a collaborative venture of The Alabama Space Grant Consortium, The Alabama EPSCoR, and faculty and staff at 10 Alabama colleges and universities as well as the Alabama School of Math and Science in Mobile. There are two Research Clusters which include infrastructure-building and outreach elements embedded in their research activities. Each of the two Research Clusters is in an area of clear and demonstrable relevance to NASA's mission, to components of other Alabama EPSCoR projects, and to the State of Alabama's economic development. This Final Report summarizes and reports upon those additional activities occurring after the first report was submitted in March 2000 (included here as Appendix C). Since the nature of the activities and the manner in which they relate to one another differ by cluster, these clusters function independently and are summarized in parallel in this report. They do share a common administration by the Alabama Space Grant Consortium (ASGC) and by this means, good ideas from each group were communicated to the other, as appropriate. During the past year these research teams, involving 15 scientists, 16 graduate students, 16 undergraduates, and 7 high school students involving 10 Alabama universities had 14 peer reviewed scientific journal articles published, 21 others reviewed for publication or published in proceedings, gave 7 formal presentations and numerous informal presentations to well over 3000 people, received 3 patents and were awarded 14 research proposals for more than $213K dollars in additional research related to these investigations. Each cluster's activities are described and an Appendix summarizes these achievements.

  16. Experimental facilities for research of properties and behaviour of fluoride salts

    International Nuclear Information System (INIS)

    Hosnedl, P.; Jilek, M.; Kroc, V.; Pedal, L.; Valenta, V.; Vodicka, J.

    1999-01-01

    SKODA JS s.r.o. (Czech leading nuclear technology manufacturer) prepared and manufactured experimental loops for research and verification of properties and behaviour of fluoride salts for primary and secondary circuit, construction materials and ADTT systems technological components for the operation in the Nuclear Research Institute Rez plc fluorine chemistry laboratory. This paper presents charts and experimental program for molten fluoride salts experimental loops with natural circulation. Further on, the paper describes extension of the loops for research with forced circulation and next works for steam generator model verification and connection with the loop of Energovyzkum Brno. The loops are designed and constructed to obtain a sufficient amount of experience on ADTT technology. The research and utilisation program covers questions of corrosion and intergranular corrosion of structural materials, research of material properties and welding, research of fluoride fluid properties, measuring of thermo-hydraulic properties of molten salt fluoride fluids, heat transfer and hydraulics, development and tests of some plant components (steam generators, heat exchangers, pumps, valves) and other engineering issues. Two electrolyzers have been manufactured for the research of fuel/coolant fluoride salts mixture purification. One for the production of hydrogen fluoride, and the other for the research of salts purification. (author)

  17. Models of policy-making and their relevance for drug research.

    Science.gov (United States)

    Ritter, Alison; Bammer, Gabriele

    2010-07-01

    Researchers are often frustrated by their inability to influence policy. We describe models of policy-making to provide new insights and a more realistic assessment of research impacts on policy. We describe five prominent models of policy-making and illustrate them with examples from the alcohol and drugs field, before drawing lessons for researchers. Policy-making is a complex and messy process, with different models describing different elements. We start with the incrementalist model, which highlights small amendments to policy, as occurs in school-based drug education. A technical/rational approach then outlines the key steps in a policy process from identification of problems and their causes, through to examination and choice of response options, and subsequent implementation and evaluation. There is a clear role for research, as we illustrate with the introduction of new medications, but this model largely ignores the dominant political aspects of policy-making. Such political aspects include the influence of interest groups, and we describe models about power and pressure groups, as well as advocacy coalitions, and the challenges they pose for researchers. These are illustrated with reference to the alcohol industry, and interest group conflicts in establishing a Medically Supervised Injecting Centre. Finally, we describe the multiple streams framework, which alerts researchers to 'windows of opportunity', and we show how these were effectively exploited in policy for cannabis law reform in Western Australia. Understanding models of policy-making can help researchers maximise the uptake of their work and advance evidence-informed policy.

  18. Effects of HPMC substituent pattern on water up-take, polymer and drug release: An experimental and modelling study.

    Science.gov (United States)

    Caccavo, Diego; Lamberti, Gaetano; Barba, Anna Angela; Abrahmsén-Alami, Susanna; Viridén, Anna; Larsson, Anette

    2017-08-07

    The purpose of this study was to investigate the hydration behavior of two matrix formulations containing the cellulose derivative hydroxypropyl methylcellulose (HPMC). The two HPMC batches investigated had different substitution pattern along the backbone; the first one is referred to as heterogeneous and the second as homogenous. The release of both the drug molecule theophylline and the polymer was determined. Additionally, the water concentrations at different positions in the swollen gel layers were determined by Magnetic Resonance Imaging. The experimental data was compared to predicted values obtained by the extension of a mechanistic Fickian based model. The hydration of tablets containing the more homogenous HPMC batch showed a gradual water concentration gradient in the gel layer and could be well predicted. The hydration process for the more heterogeneous batch showed a very abrupt step change in the water concentration in the gel layer and could not be well predicted. Based on the comparison between the experimental and predicted data this study suggests, for the first time, that formulations with HPMC of different heterogeneities form gels in different ways. The homogeneous HPMC batch exhibits a water sorption behavior ascribable to a Ficḱs law for the diffusion process whereas the more heterogeneous HPMC batches does not. This conclusion is important in the future development of simulation models and in the understanding of drug release mechanism from hydrophilic matrices. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. The patient's safety and access to experimental drugs after the termination of clinical trials: regulations and trends.

    Science.gov (United States)

    da Silva, Ricardo Eccard; Amato, Angélica Amorim; Sousa, Thiago do Rego; de Carvalho, Marta Rodrigues; Novaes, Maria Rita Carvalho Garbi

    2018-05-12

    Participants' rights and safety must be guaranteed not only while a clinical trial is being conducted but also when a clinical trial finishes. The criteria for post-trial access to experimental drugs, however, are unclear in various countries. The objectives of this study were (i) to ascertain if there were regulations or guidelines related to patients' access to drugs after the end of clinical trials in the countries selected in the study and (ii) to analyze trends in post-trial access in countries classified by their level of economic development. This study is a retrospective review. The data are from the records of clinical trials from 2014 registered in the World Health Organization's International Clinical Trials Registry Platform (ICTRP) database. Among the countries selected, provision of drugs post-trial is mandatory only in Argentina, Brazil, Chile, Finland, and Peru. The plans for post-trial access tend to be more present in low- and middle-income and upper middle-income countries, in comparison with high-income countries. Studies involving vulnerable populations are 2.53 times more likely to have plans for post-trial access than studies which do not. The guaranteeing of post-trial access remains mandatory in few countries. Considering that individuals seen as vulnerable have been included in clinical trials without plans for post-trial access, stakeholders must discuss the need to develop regulations mandating the guaranteeing of post-trial access in specified situations.

  20. Radioprotective drugs: a synopsis of current research and a proposed research plan for the Federal Emergency Management Agency. Final report

    International Nuclear Information System (INIS)

    Hickman, R.; Anspaugh, L.

    1985-04-01

    FEMA has broad roles in the management of disasters potentially involving substantial amounts of radioactive contamination. These could be either peacetime or wartime disasters. A meeting was held in March 1985 to see if there are any research contributions that FEMA might reasonably make in the area of radioprotective drugs that would substantially enhance its ability to perform its mission. The other federal agencies presently sponsoring research in the field were represented at the meeting. A few selected researchers also participated to provide complementary viewpoints. Activities of a modest scale that FEMA might undertake were identified, as were larger scale activities that might be undertaken in the event of long-term, major funding-level increases for FEMA. 2 refs

  1. Experimental research of liquid entrainment through ADS-4 in AP1000

    International Nuclear Information System (INIS)

    Meng, Zhaoming; Dong, Bo; Wang, Laishun; Fu, Xiaoliang; Tian, Wenxi; Yang, Yanhua; Su, Guanghui

    2014-01-01

    Highlights: • We performed experimental research of liquid entrainment through ADS-4 in AP1000. • Effect of various factors on entrainment at T-junction was conducted. • Visualization research was conducted to make entrainment mechanism clear. - Abstract: In this study, based on a T-junction that consists of Automatic Depressurization System Stage Four (ADS-4) and hot leg in an AP1000 plant, a small-scale experimental research on entrainment at a T-junction was performed. This study mainly focused on the effect of various factors on entrainment, such as the effect of branch size, branch shape and liquid crossflow. The flow pattern map was plotted from the experimental data, and the visualization research indicated that the entrainment phenomena through a large size branch were apparently different from that through a small branch. Three entrainment phenomena were observed in the studies, two entrainment mechanisms could be found in the stratified flow regime entrainment area, the existence of branch contributed to generating intermittent flow in the horizontal main pipe, and the backflow region was observable in the vicinity of a large size branch inlet. Also, experimental research showed that downstream of the branch of T-junction had an important effect on the onset entrainment, and liquid crossflow did not seem to affect the onset entrainment

  2. Experimental investigation of drug delivery using a super pulse CO2 laser

    International Nuclear Information System (INIS)

    Khosroshahi, M. E.; Jafari, A.; Mansoori, S.

    2006-01-01

    We have carried out an experiment using a super long CO 2 laser pulse (10 ms) on simulated gelatin-ink model. The mechanism of laser-gelatin-ink model interaction was studied by photothermal deflection and time-resolved dynamics techniques and fast photography. It seems that the main operating mechanisms with super long CO 2 laser where the absorption coefficient of gelatin-ink model is high, are photothermal vaporization and photomechanical photophorosis and cavitation collapse. The drug molecules can be transported into the tissue bulk described by the Fick's law for a given cavity geometry and mechanical waves, unlike only by pure photomechanical waves (id est photo acoustically) as with short pulses.

  3. Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.

    Science.gov (United States)

    Nakata, M; Tang, W

    2008-10-01

    research in Asian countries. (reported on October 1st, with grateful thanks to all participants) Main program Session I. Research Advances in Drug Discoveries and Therapeutics ● Design, synthesis and preliminary activity assay of influenza virus neuraminidase inhibitors by Wenfang Xu (Shandong University, China) ● Infection disease models with silkworms to evaluate the therapeutic effects of drug candidates by Kazuhisa Sekimizu (The University of Tokyo, Japan) ● Japan's governmental approaches to facilitate drug development process by Makoto Shimoaraiso (Ministry of Foreign Affairs of Japan, Japan) ● Effective detection of the epidermal growth factor receptor mutation by the peptide nucleic acid-locked nucleic acid PCR Clamp by Sakuo Hoshi (The University of Tokyo Hospital, Japan) ● Design and synthesis of p53-MDM2 binding inhibitors by Yongzhou Hu (Zhejiang University, China) Session II. Drug Synthesis/Clinical Therapeutics ● Pharmacogenomics-based clinical studies using a novel fully-automated genotyping system by Setsuo Hasegawa (Sekino Clinical Pharmacology Clinic, Japan) ● Synthesis and biological evaluation of pentacyclic triterpenes as anti-tumor agents by Hongbin Sun (China Pharmaceutical University, China) ● Drug discovery and therapeutics using silkworm as experimental animal by Yasuyuki Ogata (The University of Tokyo, Japan) ● Novel selective estrogen recetpor modulators (SERMs) with unusual structure and biological activities by Haibing Zhou (Wuhan University, China) Session III. Medicinal Chemistry/Natural Products ● Synthesis and properties of isonucleosides incorporated oligonucleotides by Zhenjun Yang (Peking University, China) ● Isolation of antiviral compounds from plant resources using silkworm bioassay by Yutaka Orihara (The University of Tokyo, Japan) ● Synthesis and structural modifcation of tasiamide and the effect of these modifications on in vitro anticancer activity by Yingxia Li (Ocean University of China, China)

  4. EXPERIMENTAL RESEARCH CONCERNING THE OPTIMAL DIMENSIONS OF AN ELASTIC STRUCTURE OF BEECH WOOD PARQUET

    Directory of Open Access Journals (Sweden)

    Olimpia-Minerva ȚURCAȘ (DIACONU

    2015-12-01

    Full Text Available This paper presents the results of the experimental research concerning the modulus of elasticity and the average value of the bending strength in case of beech (Fagus sylvatica L. wood. The investigations were performed according to SR EN 408-2004. The results of the research have been analysed in order to establish the variable parameters to be considered for the final experimental research focused on beech wood floor structures that meet the necessary requirements for the sports halls applications. The research presented in the paper is a part of the study theme of the Ph. D. thesis, which investigates the flooring structures able to support the requirements of sports halls activities, different from one sport to another.

  5. Research ethics I: Responsible conduct of research (RCR)--historical and contemporary issues pertaining to human and animal experimentation.

    Science.gov (United States)

    Horner, Jennifer; Minifie, Fred D

    2011-02-01

    In this series of articles--Research Ethics I, Research Ethics II, and Research Ethics III--the authors provide a comprehensive review of the 9 core domains for the responsible conduct of research (RCR) as articulated by the Office of Research Integrity. In Research Ethics I, they present a historical overview of the evolution of RCR in the United States then examine the evolution of human and animal experimentation from the birth of scientific medicine through World War II to the present day. They relied on authoritative documents, both historical and contemporary, insightful commentary, and empirical research in order to identify current issues and controversies of potential interest to both faculty and students. The authors have written this article from a historical perspective because they think all readers interested in RCR should appreciate how the history of science and all the good--and harm--it has produced can inform how researchers practice responsible research in the 21st century and beyond.

  6. A summary of research-based assessment of students' beliefs about the nature of experimental physics

    Science.gov (United States)

    Wilcox, Bethany R.; Lewandowski, H. J.

    2018-03-01

    Within the undergraduate physics curriculum, students' primary exposure to experimental physics comes from laboratory courses. Thus, as experimentation is a core component of physics as a discipline, lab courses can be gateways in terms of both recruiting and retaining students within the physics major. Physics lab courses have a wide variety of explicit and/or implicit goals for lab courses, including helping students to develop expert-like beliefs about the nature and importance of experimental physics. To assess students' beliefs, attitudes, and expectations about the nature of experimental physics, there is currently one research-based assessment instrument available—the Colorado Learning Attitudes about Science Survey for Experimental Physics (E-CLASS). Since its development, the E-CLASS has been the subject of multiple research studies aimed at understanding and evaluating the effectiveness of various laboratory learning environments. This paper presents a description of the E-CLASS assessment and a summary of the research that has been done using E-CLASS data with a particular emphasis on the aspects of this work that are most relevant for instructors.

  7. Experimental research of the effects of different shields on power frequency electric field mitigation

    Directory of Open Access Journals (Sweden)

    Nahman Jovan

    2012-01-01

    Full Text Available The paper describes experimental research on the effects of different shields on power frequency electric field mitigation. This research was performed in order to determine those materials that may be used for electric field mitigation in cases where the reference level is exceeded. Using measured results, the value of the shielding factor has been calculated for all tested shields and the most efficient shields were determined.

  8. Structural concepts and experimental considerations for a versatile high-speed research airplane

    Science.gov (United States)

    Jackson, L. R.; Kirkham, F. S.; Weidner, J. P.

    1978-01-01

    Future aircraft may be hydrogen fueled and fly at hypersonic speeds. The resulting environments will require new structural concepts to satisfy performance goals. Large representative structures will have to be flight tested prior to commitment to a costly vehicle fleet. To perform flight tests, a versatile, economical, high-speed research airplane is defined. Results of this study including experimental considerations for a hypersonic research airplane are reported.

  9. Experimental research of slab cast over precast joists with prestressed reinforcement

    Directory of Open Access Journals (Sweden)

    Koyankin Aleksandr Aleksandrovich

    2016-03-01

    Full Text Available At the present time reinforced concrete is the main construction material in civil and industrial construction. Cast-in-place and precast construction is gradually becoming a more widespread type of house-building, but still there is a lack of data, including experimental data, which allows evaluating the stress and strain state of a construction of a slab cast over precast joists. Experimental research of stress and strain state of slab cast over precast joists with prestressed reinforcement was carried out. An experimental model of a fragment of a hybrid precast/cast-in-place building was produced and tested (reduction scale 1:6. The experimental investigations of slab cast over precast joists with prestressed reinforcement proved that the construction solution of the framework offered in the previous works of the authors possess good stiffness, crack-resistance and bearing capacity. It well fits for constructing the slabs of long spans in residential and public buildings.

  10. 27 CFR 19.71 - Experimental or research operations by scientific institutions and colleges of learning.

    Science.gov (United States)

    2010-04-01

    ... operations by scientific institutions and colleges of learning. 19.71 Section 19.71 Alcohol, Tobacco Products... Experimental or research operations by scientific institutions and colleges of learning. (a) General. The appropriate TTB officer may authorize any scientific university, college of learning, or institution of...

  11. No Randomization? No Problem: Experimental Control and Random Assignment in Single Case Research

    Science.gov (United States)

    Ledford, Jennifer R.

    2018-01-01

    Randomization of large number of participants to different treatment groups is often not a feasible or preferable way to answer questions of immediate interest to professional practice. Single case designs (SCDs) are a class of research designs that are experimental in nature but require only a few participants, all of whom receive the…

  12. The Experimental Social Scientific Model in Speech Communication Research: Influences and Consequences.

    Science.gov (United States)

    Ferris, Sharmila Pixy

    A substantial number of published articles in speech communication research today is experimental/social scientific in nature. It is only in the past decade that scholars have begun to put the history of communication under the lens. Early advocates of the adoption of the method of social scientific inquiry were J. A. Winans, J. M. O'Neill, and C.…

  13. Objective Markers of the analgesic response to morphine in experimental pain research

    DEFF Research Database (Denmark)

    Brokjær, Anne; Olesen, Anne Estrup; Kreilgaard, Mads

    2015-01-01

    INTRODUCTION: In experimental pain research the effect of opioids is normally assessed by verbal subjective response to analgesia. However, as many confounders in pain assessment exist, objective bed-side assessment of the effect is highly warranted. Therefore, we aimed to assess the effect...

  14. Built for the future: New directions in silviculture research and demonstration at Montana's Lubrecht Experimental Forest

    Science.gov (United States)

    Christopher R. Keyes; Thomas E. Perry

    2010-01-01

    Manipulative experiments at the University of Montana’s Lubrecht Experimental Forest have long been set aside as permanent research and demonstration areas (RDA’s) to communicate the tradeoffs among different stand management strategies. However, most of these have either degraded over time or have diminished relevance to contemporary forest management issues. An...

  15. An engineering approach to business model experimentation – an online investment research startup case study

    NARCIS (Netherlands)

    Kijl, Björn; Boersma, Durk

    2010-01-01

    Every organization needs a viable business model. Strikingly, most of current literature is focused on business model design, whereas there is almost no attention for business model validation and implementation and related business model experimentation. The goal of the research as described in

  16. The Experimental Stand for Research of Wakefield Method of Charged Particles Acceleration

    International Nuclear Information System (INIS)

    Kiselev, V.A.; Linnik, A.F.; Onishchenko, I.N.; Onishchenko, N.I.; Sotnikov, G.V.; Uskov, V.V.

    2006-01-01

    The experimental installation and diagnostic equipment with motivation to use for various researches of wakefield method of charged particles acceleration both in plasma and in dielectric structure has been described. The main parameters of a sequence of short relativistic electron bunch and values of physical characteristics of slow-down structures have been presented

  17. EXPERIMENTAL RESEARCH OF PROCESSING OF DUMP SAND-CLAY MIXES BY THE CENTRIFUGAL AND SHOCK CRUSHING

    Directory of Open Access Journals (Sweden)

    V. V. Vorobev

    2015-01-01

    Full Text Available Results of experimental research of processing of centrifugal and shock crushing of dump sandy-clay mixes are given. Use of products of processing of received mixes in foundry production and in production of asphalt concrete mixes allows to exclude transportation of the mix to dumping.

  18. Long-term trends from ecosystem research at the Hubbard Brook Experimental Forest

    Science.gov (United States)

    John L. Campbell; Charles T. Driscoll; Christopher Eagar; Gene E. Likens; Thomas G. Siccama; Chris E. Johnson; Timothy J. Fahey; Steven P. Hamburg; Richard T. Holmes; Amey S. Bailey; Donald C. Buso

    2007-01-01

    Summarizes 52 years of collaborative, long-term research conducted at the Hubbard Brook (NH) Experimental Forest on ecosystem response to disturbances such as air pollution, climate change, forest disturbance, and forest management practices. Also provides explanations of some of the trends and lists references from scientific literature for further reading.

  19. THE RESEARCH RESULTS OF TENDER PROCUREMENTS OF THE DRUGS FOR CANCER PATIENTS IN UKRAINE

    Directory of Open Access Journals (Sweden)

    G. L. Panfilova

    2014-02-01

    Full Text Available Introduction. Since 2002, the pharmaceutical care of the cancer patients in Ukraine is carried out centrally by public funds in the framework of the target program "Oncology." In a chronic shortage of funds in the national health care system, as well as taking into account the perspectives of the introduction of the social model of obligatory medical insurance (OMI, enhanced the importance of research on the development of rational mechanisms for the use of public funds, which are sent to drug purchases. Given the high mortality rate among cancer patients, especially in children in Ukraine, these works are of particular socio-economic importance. The aim of work. To study drug purchases that are made for cancer patients in Ukraine in order to identify the main problems and directions of rational scientific basis for the use of public funds in terms of lack of resources in health care, as well as from the perspectives of the introduction of the social model of OMI in Ukraine. Materials and methods. Objects of research: data from the National Cancer Registry, annual plans and registers of public drug procurement Ministry of Ukraine. The paper used data from national legislative and regulatory framework governing the organization of pharmaceutical support cancer patients, standard methods of statistical processing of the dynamics of the clinic-economic analysis. Results and discussion. During 2010-2013 marked increase in the amounts of permanent drug purchases for cancer patients, which is on the growth rate did not meet the dynamics of changes in the relevant during epidemiological indicators. The results integrated ABC/VEN-analysis found no drug purchasing products from the group N and with the status A/V, and the dominance of the number of agents with the status items C/V. The main volume of financial resources was directed to the purchase of drugs from the group E (84.8% - 92.4% and the status of A/E (78,9% -79,8%, as well as drug belonging to

  20. Drug research methodology. Volume 3, The detection and quantitation of drugs of interest in body fluids from drivers

    Science.gov (United States)

    1980-03-01

    This report presents the findings of a workshop on the chemical analysis of human body fluids for drugs of interest in highway safety. A cross-disciplinary panel of experts reviewed the list of drugs of interest developed in a previous workshop and d...

  1. Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children.

    Science.gov (United States)

    Seddon, James A; Perez-Velez, Carlos M; Schaaf, H Simon; Furin, Jennifer J; Marais, Ben J; Tebruegge, Marc; Detjen, Anne; Hesseling, Anneke C; Shah, Sarita; Adams, Lisa V; Starke, Jeffrey R; Swaminathan, Soumya; Becerra, Mercedes C

    2013-06-01

    Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The World Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DR-TB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome. © The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society.

  2. [Caffeine as a preventive drug for Parkinson's disease: epidemiologic evidence and experimental support].

    Science.gov (United States)

    Góngora-Alfaro, José Luis

    Prospective epidemiologic studies performed in large cohorts of men (total: 374,003 subjects) agree in which the risk of suffering Parkinson's disease diminishes progressively as the consumption of coffee and other caffeinated beverages increases. In the case of women (total: 345,184 subjects) the protective effect of caffeine is only observed in menopausal women which do not receive estrogen replacement therapy. Studies with models of acute parkinsonism in rodents have shown that caffeine reduces the loss of nigrostriatal dopaminergic neurons induced with the neurotoxins 6-hidroxidopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, effect that seems to be mediated through blockade of A(2A) adenosine receptors. Recently, it was shown that male rats treated with moderate doses of caffeine (5 mg/kg/day) during six months, followed by a withdrawal period of at least two weeks, developed a greater resistance to the catalepsy induced with the dopaminergic antagonist haloperidol, which was possibly mediated by an increase of dopaminergic transmission in the corpus striatum. More studies are needed to demonstrate unequivocally that caffeine prevents the degeneration of dopaminergic neurons in animal models of moderate, chronic, and progressive parkinsonism, since it could lead to the discovery of more effective drugs for the prevention of aging-related degenerative diseases of the central nervous system.

  3. Animal experimentation

    OpenAIRE

    Laz, Alak; Cholakova, Tanya Stefanova; Vrablova, Sofia; Arshad, Naverawaheed

    2016-01-01

    Animal experimentation is a crucial part of medical science. One of the ways to define it is any scientific experiment conducted for research purposes that cause any kind of pain or suffering to animals. Over the years, the new discovered drugs or treatments are first applied on animals to test their positive outcomes to be later used by humans. There is a debate about violating ethical considerations by exploiting animals for human benefits. However, different ethical theories have been made...

  4. Glioma Surgical Aspirate: A Viable Source of Tumor Tissue for Experimental Research

    International Nuclear Information System (INIS)

    Day, Bryan W.; Stringer, Brett W.; Wilson, John; Jeffree, Rosalind L.; Jamieson, Paul R.

    2013-01-01

    Brain cancer research has been hampered by a paucity of viable clinical tissue of sufficient quality and quantity for experimental research. This has driven researchers to rely heavily on long term cultured cells which no longer represent the cancers from which they were derived. Resection of brain tumors, particularly at the interface between normal and tumorigenic tissue, can be carried out using an ultrasonic surgical aspirator (CUSA) that deposits liquid (blood and irrigation fluid) and resected tissue into a sterile bottle for disposal. To determine the utility of CUSA-derived glioma tissue for experimental research, we collected 48 CUSA specimen bottles from glioma patients and analyzed both the solid tissue fragments and dissociated tumor cells suspended in the liquid waste fraction. We investigated if these fractions would be useful for analyzing tumor heterogeneity, using IHC and multi-parameter flow cytometry; we also assessed culture generation and orthotopic xenograft potential. Both cell sources proved to be an abundant, highly viable source of live tumor cells for cytometric analysis, animal studies and in-vitro studies. Our findings demonstrate that CUSA tissue represents an abundant viable source to conduct experimental research and to carry out diagnostic analyses by flow cytometry or other molecular diagnostic procedures

  5. Animal models in biological and biomedical research - experimental and ethical concerns.

    Science.gov (United States)

    Andersen, Monica L; Winter, Lucile M F

    2017-09-04

    Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. In this review, we intend to give examples on how animals are used in the health research related to some major health problems in Brazil, as well as to stimulate discussion about the application of ethics in the use of animals in research and education, highlighting the role of National Council for the Control of Animal Experimentation (Conselho Nacional de Controle de Experimentação Animal - CONCEA) in these areas. In 2008, Brazil emerged into a new era of animal research regulation, with the promulgation of Law 11794, previously known as the Arouca Law, resulting in an increased focus, and rapid learning experience, on questions related to all aspects of animal experimentation. The law reinforces the idea that animal experiments must be based on ethical considerations and integrity-based assumptions, and provides a regulatory framework to achieve this. This review describes the health research involving animals and the current Brazilian framework for regulating laboratory animal science, and hopes to help to improve the awareness of the scientific community of these ethical and legal rules.

  6. An experimental study of percutaneous vertebroplasty using instruments and drugs made in China

    International Nuclear Information System (INIS)

    Sun Gang; Jin Peng; Xie Zonggui; Yi Yumei; Zhang Xuping; Cong Yongjian

    2003-01-01

    Objective: To evaluate the efficacy of percutaneous vertebroplasty (PVP) using instruments and drugs made in China, and to provide the data for the clinical application. Methods: Polymethylmethacrylate (PMMA) without adding contrast was classified into 3 groups according to the ratio of powder/liquid as 2:1, 3:2, 1:1, PMMA with contrast was also classified into 3 groups according to the ratio of powder/liquid/contrast as 2:1:1, 3:2:1, 1:1:1. There were 6 groups totally. the periods and temperature of polymerizing process were measured. The PMMA specimens of different group were made, with the diameter of 1.0 cm, height of 3.0 cm. The density was determined in X-ray pictures and mechanical testing with universal testing machine was performed. PVP was performed in the spines of 3 human cadavers with transpedicular route under fluoroscopic control. The PMMA was injected into vertebra at an interval of one vertebra from T4-L4, 7 vertebra were injected on each cadaver. The injected volume was recorded. the spines were dissected into 42 single vertebrae, with all soft tissues removed. Overall, 21 pairs of adjacent vertebrae were subjected to axial compression in an universal testing machine. The cranial vertebra of each pair was injected with PMMA, the caudal one served as a control. Results: Lower temperature was observed in the PMMA groups with adding contrast than those without adding contrast during the polymerizing process, the average temperature in the PMMA group with the ratio of powder/liquid/contrast as 3:2:1 was 67.4 degree C. There was significant X-ray density difference between the groups with contrast and corresponding groups without contrast (t=20.00, t=20.00, t=22.86, P 0.05). The group with ratio of power/liquid/contrast 3:2:1 was (127±4.70) s in the period of the paste, and the ultimate compressive strength (mPa) was 47.23. The punctures were successfully reached in all vertebra. The injected PMMA average volume was 5 ml in the thoracic vertebra and 7

  7. Experimental study of the preventional effects of drugs to lung radiation damage

    Energy Technology Data Exchange (ETDEWEB)

    Tomita, N [Kurume Univ., Fukuoka (Japan). School of Medicine

    1977-01-01

    The author experimented on effects of Cepharanthin (CR) and Urokinase (UK) on the lung of rabbits to which /sup 60/Co was irradiated by dividing a total dose of 10,000R into 500R a day. The rabbits irradiated were divided into 3 groups: a group administered ''CR'' (Group A), a group administered ''UK'' (Group B) and a control group (Group C). Body weight, leukocytes and chest x-ray findings were examined, and macroscopic and microscopic findings were discussed immediately and 3 months after irradiation. CR was effective in preventing the decrease of leukocytes and body weight. In the case of 5000R irradiation, an abnormal shadow was not recognized, but in the case of 10,000R irradiation, radiation pneumonitis began to appear immediately after the irradiation, and heart dilation and the shift of mediastinum on the side of irradiation were observed 3 months after that. In Group C, adhesion, hydropericardium and bleeding lesion were observed. In Groups A and B, the preventive effects were noted macroscopically. Group A seemed to show more significant results. In this group, the infiltration of the cells, and the appearance of foamy cells and eosinophyl cells which are characteristic of lung radiation disease were less observed than those in the other groups, and therefore, Group A showed more preventive effect upon inflammation than the other groups. In Group B, the thickness of the wall of the blood vessel tended to be improved 3 months after irradiation. Microthrombosis was not recognized, either. From these results, CR was effective in decreasing the infiltration of the cells, and UK was effective in decreasing the thickness of the wall of the blood vessel and in forming thromboses. Thus, these drugs should be used simultaneously because they had different reaction to the prevention of lung radiation disease.

  8. The experimental study of the preventional effects of drugs to lung radiation damage

    International Nuclear Information System (INIS)

    Tomita, Naoaki

    1977-01-01

    The author experimented on effects of Cepharanthin (CR) and Urokinase (UK) on the lung of rabbits to which 60 Co was irradiated by dividing a total dose of 10,000R into 500R a day. The rabbits irradiated were divided into 3 groups: a group administered ''CR'' (Group A), a group administered ''UK'' (Group B) and a control group (Group C). Body weight, leukocytes and chest x-ray findings were examined, and macroscopic and microscopic findings were discussed immediately and 3 months after irradiation. CR was effective in preventing the decrease of leukocytes and body weight. In the case of 5000R irradiation, an abnormal shadow was not recognized, but in the case of 10,000R irradiation, radiation pneumonitis began to appear immediately after the irradiation, and heart dilation and the shift of mediastinum on the side of irradiation were observed 3 months after that. In Group C, adhesion, hydropericardium and bleeding lesion were observed. In Groups A and B, the preventive effects were noted macroscopically. Group A seemed to show more significant results. In this group, the infiltration of the cells, and the appearance of foamy cells and eosinophyl cells which are characteristic of lung radiation disease were less observed than those in the other groups, and therefore, Group A showed more preventive effect upon inflammation than the other groups. In Group B, the thickness of the wall of the blood vessel tended to be improved 3 months after irradiation. Microthrombosis was not recognized, either. From these results, CR was effective in decreasing the infiltration of the cells, and UK was effective in decreasing the thickness of the wall of the blood vessel and in forming thromboses. Thus, these drugs should be used simultaneously because they had different reaction to the prevention of lung radiation disease. (J.P.N.)

  9. Inclusion of quasi-experimental studies in systematic reviews of health systems research.

    Science.gov (United States)

    Rockers, Peter C; Røttingen, John-Arne; Shemilt, Ian; Tugwell, Peter; Bärnighausen, Till

    2015-04-01

    Systematic reviews of health systems research commonly limit studies for evidence synthesis to randomized controlled trials. However, well-conducted quasi-experimental studies can provide strong evidence for causal inference. With this article, we aim to stimulate and inform discussions on including quasi-experiments in systematic reviews of health systems research. We define quasi-experimental studies as those that estimate causal effect sizes using exogenous variation in the exposure of interest that is not directly controlled by the researcher. We incorporate this definition into a non-hierarchical three-class taxonomy of study designs - experiments, quasi-experiments, and non-experiments. Based on a review of practice in three disciplines related to health systems research (epidemiology, economics, and political science), we discuss five commonly used study designs that fit our definition of quasi-experiments: natural experiments, instrumental variable analyses, regression discontinuity analyses, interrupted times series studies, and difference studies including controlled before-and-after designs, difference-in-difference designs and fixed effects analyses of panel data. We further review current practices regarding quasi-experimental studies in three non-health fields that utilize systematic reviews (education, development, and environment studies) to inform the design of approaches for synthesizing quasi-experimental evidence in health systems research. Ultimately, the aim of any review is practical: to provide useful information for policymakers, practitioners, and researchers. Future work should focus on building a consensus among users and producers of systematic reviews regarding the inclusion of quasi-experiments. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Modulation of Antioxidant Enzymatic Activities by Certain Antiepileptic Drugs (Valproic Acid, Oxcarbazepine, and Topiramate): Evidence in Humans and Experimental Models

    Science.gov (United States)

    Cárdenas-Rodríguez, Noemí; Coballase-Urrutia, Elvia; Rivera-Espinosa, Liliana; Romero-Toledo, Arantxa; Sampieri, Aristides III; Ortega-Cuellar, Daniel; Montesinos-Correa, Hortencia; Floriano-Sánchez, Esaú; Carmona-Aparicio, Liliana

    2013-01-01

    It is estimated that at least 100 million people worldwide will suffer from epilepsy at some point in their lives. This neurological disorder induces brain death due to the excessive liberation of glutamate, which activates the postsynaptic N-methyl-D-aspartic acid (NMDA) receptors, which in turn cause the reuptake of intracellular calcium (excitotoxicity). This excitotoxicity elicits a series of events leading to nitric oxide synthase (NOS) activation and the generation of reactive oxygen species (ROS). Several studies in experimental models and in humans have demonstrated that certain antiepileptic drugs (AEDs) exhibit antioxidant effects by modulating the activity of various enzymes associated with this type of stress. Considering the above-mentioned data, we aimed to compile evidence elucidating how AEDs such as valproic acid (VPA), oxcarbazepine (OXC), and topiramate (TPM) modulate oxidative stress. PMID:24454986

  11. Modulation of Antioxidant Enzymatic Activities by Certain Antiepileptic Drugs (Valproic Acid, Oxcarbazepine, and Topiramate: Evidence in Humans and Experimental Models

    Directory of Open Access Journals (Sweden)

    Noemí Cárdenas-Rodríguez

    2013-01-01

    Full Text Available It is estimated that at least 100 million people worldwide will suffer from epilepsy at some point in their lives. This neurological disorder induces brain death due to the excessive liberation of glutamate, which activates the postsynaptic N-methyl-D-aspartic acid (NMDA receptors, which in turn cause the reuptake of intracellular calcium (excitotoxicity. This excitotoxicity elicits a series of events leading to nitric oxide synthase (NOS activation and the generation of reactive oxygen species (ROS. Several studies in experimental models and in humans have demonstrated that certain antiepileptic drugs (AEDs exhibit antioxidant effects by modulating the activity of various enzymes associated with this type of stress. Considering the above-mentioned data, we aimed to compile evidence elucidating how AEDs such as valproic acid (VPA, oxcarbazepine (OXC, and topiramate (TPM modulate oxidative stress.

  12. On the mechanics of cerebral aneurysms: experimental research and numerical simulation

    Science.gov (United States)

    Parshin, D. V.; Kuianova, I. O.; Yunoshev, A. S.; Ovsyannikov, K. S.; Dubovoy, A. V.

    2017-10-01

    This research extends existing experimental data for CA tissues [1, 2] and presents the preliminary results of numerical calculations. Experiments were performed to measure aneurysm wall stiffness and the data obtained was analyzed. To reconstruct the geometry of the CAs, DICOM images of real patients with aneurysms and ITK Snap [3] were used. In addition, numerical calculations were performed in ANSYS (commercial software, License of Lavrentyev Institute of Hydrodynamics). The results of these numerical calculations show a high level of agreement with experimental data from previous literature.

  13. Effect of drug utilization reviews on the quality of in-hospital prescribing: a quasi-experimental study

    Directory of Open Access Journals (Sweden)

    Chabot Isabelle

    2006-03-01

    Full Text Available Abstract Background Drug utilization review (DUR programs are being conducted in Canadian hospitals with the aim of improving the appropriateness of prescriptions. However, there is little evidence of their effectiveness. The objective of this study was to assess the impact of both a retrospective and a concurrent DUR programs on the quality of in-hospital prescribing. Methods We conducted an interrupted time series quasi-experimental study. Using explicit criteria for quality of prescribing, the natural history of cisapride prescription was established retrospectively in three university-affiliated hospitals. A retrospective DUR was implemented in one of the hospitals, a concurrent DUR in another, whereas the third hospital served as a control. An archivist abstracted records of all patients who were prescribed cisapride during the observation period. The effect of DURs relative to the control hospital was determined by comparing estimated regression coefficients from the time series models and by testing the statistical significance using a 2-tailed Student's t test. Results The concurrent DUR program significantly improved the appropriateness of prescriptions for the indication for use whereas the retrospective DUR brought about no significant effect on the quality of prescribing. Conclusion Results suggest a retrospective DUR approach may not be sufficient to improve the quality of prescribing. However, a concurrent DUR strategy, with direct feedback to prescribers seems effective and should be tested in other settings with other drugs.

  14. Benefits of smart pumps for automated changeovers of vasoactive drug infusion pumps: a quasi-experimental study.

    Science.gov (United States)

    Cour, M; Hernu, R; Bénet, T; Robert, J M; Regad, D; Chabert, B; Malatray, A; Conrozier, S; Serra, P; Lassaigne, M; Vanhems, P; Argaud, L

    2013-11-01

    Manual changeover of vasoactive drug infusion pumps (CVIP) frequently lead to haemodynamic instability. Some of the newest smart pumps allow automated CVIP. The aim of this study was to compare automated CVIP with manual 'Quick Change' relays. We performed a prospective, quasi-experimental study, in a university-affiliated intensive care unit (ICU). All adult patients receiving continuous i.v. infusion of vasoactive drugs were included. CVIP were successively performed manually (Phase 1) and automatically (Phase 2) during two 6-month periods. The primary endpoint was the frequency of haemodynamic incidents related to the relays, which were defined as variations of mean arterial pressure >15 mm Hg or heart rate >15 bpm. The secondary endpoints were the nursing time dedicated to relays and the number of interruptions in care because of CVIP. A multivariate mixed effects logistic regression was fitted for analytic analysis. We studied 1329 relays (Phase 1: 681, Phase 2: 648) from 133 patients (Phase 1: 63, Phase 2: 70). Incidents related to CVIP decreased from 137 (20%) in Phase 1 to 73 (11%) in Phase 2 (Ppumps in limiting the frequency of haemodynamic incidents related to relays and in reducing the nursing workload.

  15. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

  16. Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements

    DEFF Research Database (Denmark)

    Di Cagno, Massimiliano Pio; Clarelli, Fabrizio; Vabenø, Jon

    2018-01-01

    or the need for dedicated instrumentation. In this work, a simple but reliable method based on time resolved concentration measurements by UV-visible spectroscopy in an unstirred aqueous environment was developed. This method is based on spectroscopic measurement of the variation of the local concentration...... characteristics (i.e. ionic strength and presence of complexing agents) on the diffusivity. The method can be employed in any research laboratory equipped with a standard UV-visible spectrophotometer, and could become a useful and straightforward tool in order to characterize diffusion coefficients...

  17. Reconciling incongruous qualitative and quantitative findings in mixed methods research: exemplars from research with drug using populations.

    Science.gov (United States)

    Wagner, Karla D; Davidson, Peter J; Pollini, Robin A; Strathdee, Steffanie A; Washburn, Rachel; Palinkas, Lawrence A

    2012-01-01

    Mixed methods research is increasingly being promoted in the health sciences as a way to gain more comprehensive understandings of how social processes and individual behaviours shape human health. Mixed methods research most commonly combines qualitative and quantitative data collection and analysis strategies. Often, integrating findings from multiple methods is assumed to confirm or validate the findings from one method with the findings from another, seeking convergence or agreement between methods. Cases in which findings from different methods are congruous are generally thought of as ideal, whilst conflicting findings may, at first glance, appear problematic. However, the latter situation provides the opportunity for a process through which apparently discordant results are reconciled, potentially leading to new emergent understandings of complex social phenomena. This paper presents three case studies drawn from the authors' research on HIV risk amongst injection drug users in which mixed methods studies yielded apparently discrepant results. We use these case studies (involving injection drug users [IDUs] using a Needle/Syringe Exchange Program in Los Angeles, CA, USA; IDUs seeking to purchase needle/syringes at pharmacies in Tijuana, Mexico; and young street-based IDUs in San Francisco, CA, USA) to identify challenges associated with integrating findings from mixed methods projects, summarize lessons learned, and make recommendations for how to more successfully anticipate and manage the integration of findings. Despite the challenges inherent in reconciling apparently conflicting findings from qualitative and quantitative approaches, in keeping with others who have argued in favour of integrating mixed methods findings, we contend that such an undertaking has the potential to yield benefits that emerge only through the struggle to reconcile discrepant results and may provide a sum that is greater than the individual qualitative and quantitative parts

  18. Structural fire resistance experimental research priority needs of U.S. industry

    CERN Document Server

    Almand, Kathleen H

    2012-01-01

    Structural Fire Resistance Experimental Research – Priority Needs of U.S. Industry provides a synthesis of stakeholder input to a prioritized agenda for research at the National Fire Research Laboratory (NFRL) at the National Institute of Standards and Technology (NIST) designed to accelerate the implementation of performance-based fire engineering for structures. The NFRL presents a broad range of unanswered questions regarding the performance of real structures in fire conditions, and informs performance-based design methods and standards in this field. The authors conducted a comprehensive literature review of large-scale structural fire testing and compiled research needs from a variety of sources. The book addresses major issues of broad concern in the fire community, such as real fire exposure and structural response, composite floor system performance, enhancing modeling performance, and understanding the embedded safety features in design methods. It concludes with a prioritized set of research reco...

  19. Recent highlights of experimental research for inhibiting tumor growth by using Chinese medicine.

    Science.gov (United States)

    He, Xi-ran; Han, Shu-yan; Li, Ping-ping

    2015-10-01

    To give an overview of contemporary experimental research using Chinese medicine (CM) for the treatment of cancer. As an integral part of mainstream medicine in the People's Republic of China, CM emphasizes improvements in holistic physical condition instead of merely killing tumor cells, which is consistent with the current medical model that advocates patient-oriented treatment. Great progress has been made in experimental research, and the principle aspects include anti-tumor angiogenesis, inducing apoptosis and differentiation, reversing multidrug resistance, and improving immune function. As a current hot topic in cancer research, tumor microenvironment (TME) highlights the mutual and interdependent interaction between tumor cells and their surrounding tissues, and the CM treatment concept bears a striking resemblance to it. To date, primary points of TME include extracellular matrix remodeling, inflammation, hypoxia, and angiogenesis, but trials using CM with a focus on TME are rare. Despite considerable recent development, experimental research on CM for solving cancer issues appears insufficient. Greater efforts in this field are urgently needed.

  20. Trafficking Golden Crescent Drugs into Western China: An Analysis and Translation of a Recent Chinese Police Research Article

    Science.gov (United States)

    2011-01-01

    illegal drug exchanges and consumption markets in Xinjiang, and soon this heroin even exceeded the market position of traditional Golden Triangle heroin...tons of the precursor chemical acetic anhydride {cusucmgan; WiW. iff) being smuggled out of the border. • 800,000 tabs of the psychoactive drug ...Trafficking Golden Crescent Drugs into Western China: An Analysis and Translation of a Recent Chinese Police Research Article Dr. Murray Scot

  1. CONCEPTUALIZATION OF IDEAS OF PSYCHOLOGICAL SAFETY IN SPORTS: PROBLEMS OF EXPERIMENTAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Yulia Vladimirovna Vardanyan

    2013-09-01

    Full Text Available This article is devoted to the research of the concept “psychological safety in sports”. On the basis of analysis of ideas about psychological safety in sports and their representation in printed or verbal form the necessity of overcoming the fragmentation and lack of system is substantiated. The authors state that one and the same sports situation can constructively or destructively affect the psychological safety of direct or indirect participants of sports events. In this context, it is important to create the psycholinguistic basis of experimental research of psychological safety in sports. Great attention is paid to systematization of the content of the concept “psychological safety in sports”. The created models of words and expressions that convey ideas about this phenomenon are of particular value. In the structure of the concept the dominant meanings, expressed in the nucleus, and additional meanings, related to the periphery of the concept are distinguished.Purpose: to explore the ideas of psychological safety in sports and their representation in printed or verbal form; to determine ways of overcoming the conceptual psycholinguistic problems in the process of experimental research of psychological safety in sports; to create the model of words and expressions which are used to verbalize the concept “psychological safety in sports”.Methodology: theoretical analysis of psychological and linguistic literature, creation of the psycholinguistic basis of experimental research, modeling of the conceptual ideas of psychological safety in sports.Results: psycholinguistic basis of experimental research of psychological safety in sports, the model of content and structure of the corresponding concept.Practical implications: Pedagogical Psychology, Sports Psychology, Philology, Psycholinguistics.DOI: http://dx.doi.org/10.12731/2218-7405-2013-8-11

  2. Choosing appropriate independent variable in educational experimental research: some errors debunked

    Science.gov (United States)

    Panjaitan, R. L.

    2018-03-01

    It is found that a number of quantitative research reports of some beginning researchers, especially undergraduate students, tend to ‘merely’ quantitative with not really proper understanding of variables involved in the research. This paper focuses on some mistakes related to independent variable determination in experimental research in education. With literature research methodology, data were gathered from an undergraduate student’s thesis as a single non-human subject. This data analysis resulted some findings, such as misinterpreted variables that should have represented the research question, and unsuitable calculation of determination coefficient due to incorrect independent variable determination. When a researcher misinterprets data as data that could behave as the independent variable but actually it could not, all of the following data processes become pointless. These problems might lead to inaccurate research conclusion. In this paper, the problems were analysed and discussed. To avert the incorrectness in processing data, it is suggested that undergraduate students as beginning researchers have adequate statistics mastery. This study might function as a resource to researchers in education to be aware to and not to redo similar errors.

  3. Invited review: Experimental design, data reporting, and sharing in support of animal systems modeling research.

    Science.gov (United States)

    McNamara, J P; Hanigan, M D; White, R R

    2016-12-01

    The National Animal Nutrition Program "National Research Support Project 9" supports efforts in livestock nutrition, including the National Research Council's committees on the nutrient requirements of animals. Our objective was to review the status of experimentation and data reporting in animal nutrition literature and to provide suggestions for the advancement of animal nutrition research and the ongoing improvement of field-applied nutrient requirement models. Improved data reporting consistency and completeness represent a substantial opportunity to improve nutrition-related mathematical models. We reviewed a body of nutrition research; recorded common phrases used to describe diets, animals, housing, and environmental conditions; and proposed equivalent numerical data that could be reported. With the increasing availability of online supplementary material sections in journals, we developed a comprehensive checklist of data that should be included in publications. To continue to improve our research effectiveness, studies utilizing multiple research methodologies to address complex systems and measure multiple variables will be necessary. From the current body of animal nutrition literature, we identified a series of opportunities to integrate research focuses (nutrition, reproduction and genetics) to advance the development of nutrient requirement models. From our survey of current experimentation and data reporting in animal nutrition, we identified 4 key opportunities to advance animal nutrition knowledge: (1) coordinated experiments should be designed to employ multiple research methodologies; (2) systems-oriented research approaches should be encouraged and supported; (3) publication guidelines should be updated to encourage and support sharing of more complete data sets; and (4) new experiments should be more rapidly integrated into our knowledge bases, research programs and practical applications. Copyright © 2016 American Dairy Science Association

  4. Experimental study on accelerator driven subcritical reactor. JAERI's nuclear research promotion program, H12-031 (Contract research)

    International Nuclear Information System (INIS)

    Shiroya, Seiji; Misawa, Tsuyoshi; Unesaki, Hironobu

    2004-03-01

    In view of the future plan of Research Reactor Institute, Kyoto University (KURRI), the present study consisted of 1) the transmission experiments of high energy neutrons through materials, 2) experimental simulation of ADSR using the Kyoto University Critical Assembly (KUCA), and 3) conceptual neutronics design study on Kyoto University Reactor (KUR) type ADSR using the MCNPX code. The purpose of the present study was not only to obtain the knowledge usable for the realization of ADSR as a new neutron source for research but also to select technical issues in the field of reactor physics for the development of ADSR in general. Through the present study, valuable knowledge on the basic nuclear characteristics of ADSR was obtained both theoretically and experimentally. This kind of knowledge is indispensable to promote the study on ADSR further. If one dare say the main part of knowledge in short words, the basic nuclear characteristics of ADSR is overwhelmed by the characteristics of the subcritical reactor as expected. For the realization of ADSR in the future, it is considered to be necessary to accumulate results of research steadily. For this purpose, it is inevitable 1) to compile the more precise nuclear data for the wide energy range, 2) to establish experimental techniques for reactor physics study on ADSR including subcriticality measurement and absolute neutron flux measurement from the low energy region to the high energy region, and 3) to develop neutronics calculation tools which facilitate to take into account the neutron generation process by the spallation reaction and the delayed neutron behavior. (author)

  5. Risk assessment and experimental design in the development of a prolonged release drug delivery system with paliperidone.

    Science.gov (United States)

    Iurian, Sonia; Turdean, Luana; Tomuta, Ioan

    2017-01-01

    This study focuses on the development of a drug product based on a risk assessment-based approach, within the quality by design paradigm. A prolonged release system was proposed for paliperidone (Pal) delivery, containing Kollidon ® SR as an insoluble matrix agent and hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC), or sodium carboxymethyl cellulose as a hydrophilic polymer. The experimental part was preceded by the identification of potential sources of variability through Ishikawa diagrams, and failure mode and effects analysis was used to deliver the critical process parameters that were further optimized by design of experiments. A D-optimal design was used to investigate the effects of Kollidon SR ratio ( X 1 ), the type of hydrophilic polymer ( X 2 ), and the percentage of hydrophilic polymer ( X 3 ) on the percentages of dissolved Pal over 24 h ( Y 1 - Y 9 ). Effects expressed as regression coefficients and response surfaces were generated, along with a design space for the preparation of a target formulation in an experimental area with low error risk. The optimal formulation contained 27.62% Kollidon SR and 8.73% HPMC and achieved the prolonged release of Pal, with low burst effect, at ratios that were very close to the ones predicted by the model. Thus, the parameters with the highest impact on the final product quality were studied, and safe ranges were established for their variations. Finally, a risk mitigation and control strategy was proposed to assure the quality of the system, by constant process monitoring.

  6. Giant Plasma Membrane Vesicles: An Experimental Tool for Probing the Effects of Drugs and Other Conditions on Membrane Domain Stability.

    Science.gov (United States)

    Gerstle, Zoe; Desai, Rohan; Veatch, Sarah L

    2018-01-01

    Giant plasma membrane vesicles (GPMVs) are isolated directly from living cells and provide an alternative to vesicles constructed of synthetic or purified lipids as an experimental model system for use in a wide range of assays. GPMVs capture much of the compositional protein and lipid complexity of intact cell plasma membranes, are filled with cytoplasm, and are free from contamination with membranes from internal organelles. GPMVs often exhibit a miscibility transition below the growth temperature of their parent cells. GPMVs labeled with a fluorescent protein or lipid analog appear uniform on the micron-scale when imaged above the miscibility transition temperature, and separate into coexisting liquid domains with differing membrane compositions and physical properties below this temperature. The presence of this miscibility transition in isolated GPMVs suggests that a similar phase-like heterogeneity occurs in intact plasma membranes under growth conditions, albeit on smaller length scales. In this context, GPMVs provide a simple and controlled experimental system to explore how drugs and other environmental conditions alter the composition and stability of phase-like domains in intact cell membranes. This chapter describes methods to generate and isolate GPMVs from adherent mammalian cells and to interrogate their miscibility transition temperatures using fluorescence microscopy. © 2018 Elsevier Inc. All rights reserved.

  7. High-temperature experimental and thermodynamic modelling research on the pyrometallurgical processing of copper

    Science.gov (United States)

    Hidayat, Taufiq; Shishin, Denis; Decterov, Sergei A.; Hayes, Peter C.; Jak, Evgueni

    2017-01-01

    Uncertainty in the metal price and competition between producers mean that the daily operation of a smelter needs to target high recovery of valuable elements at low operating cost. Options for the improvement of the plant operation can be examined and decision making can be informed based on accurate information from laboratory experimentation coupled with predictions using advanced thermodynamic models. Integrated high-temperature experimental and thermodynamic modelling research on phase equilibria and thermodynamics of copper-containing systems have been undertaken at the Pyrometallurgy Innovation Centre (PYROSEARCH). The experimental phase equilibria studies involve high-temperature equilibration, rapid quenching and direct measurement of phase compositions using electron probe X-ray microanalysis (EPMA). The thermodynamic modelling deals with the development of accurate thermodynamic database built through critical evaluation of experimental data, selection of solution models, and optimization of models parameters. The database covers the Al-Ca-Cu-Fe-Mg-O-S-Si chemical system. The gas, slag, matte, liquid and solid metal phases, spinel solid solution as well as numerous solid oxide and sulphide phases are included. The database works within the FactSage software environment. Examples of phase equilibria data and thermodynamic models of selected systems, as well as possible implementation of the research outcomes to selected copper making processes are presented.

  8. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

    Science.gov (United States)

    2013-01-01

    Liver fibrosis is defined as excessive extracellular matrix deposition and is based on complex interactions between matrix-producing hepatic stellate cells and an abundance of liver-resident and infiltrating cells. Investigation of these processes requires in vitro and in vivo experimental work in animals. However, the use of animals in translational research will be increasingly challenged, at least in countries of the European Union, because of the adoption of new animal welfare rules in 2013. These rules will create an urgent need for optimized standard operating procedures regarding animal experimentation and improved international communication in the liver fibrosis community. This review gives an update on current animal models, techniques and underlying pathomechanisms with the aim of fostering a critical discussion of the limitations and potential of up-to-date animal experimentation. We discuss potential complications in experimental liver fibrosis and provide examples of how the findings of studies in which these models are used can be translated to human disease and therapy. In this review, we want to motivate the international community to design more standardized animal models which might help to address the legally requested replacement, refinement and reduction of animals in fibrosis research. PMID:24274743

  9. Methodological and Epistemological Criticism on Experimental Accounting Research Published in Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Frederico Homero Junior

    2016-06-01

    Full Text Available In this article, I analyze 17 experimental studies published in Brazilian accounting journals between 2006 and 2015, in order to develop both critical and methodological criticism on these articles. First, we discuss the methodological characteristics of the experiments and the main validity threats they face, analyzing how the selected articles deal with these threats. Overall, this analysis shows a lack of consideration of the validity of the constructs used, difficulty to develop internally valid experiments and inability to express confidence in the applicability of the results to contexts other than the experimental. Then, I compare the positivist theoretical perspective these articles have in common with constructionist conceptions of the social sciences and criticize them, based on these notions. I maintain that these articles are characterized by a behaviorist approach, a reified notion of subjectivity, disregard of the cultural and historical specificities and axiological commitment to submission, instead of the emancipation of the people in relation to management control. The paper contributes to the Brazilian accounting literature in two ways: raising awareness on the challenges faced in conducting appropriate experimental designs and showing how the experimental accounting research can be problematic from an epistemological point of view, aiming to promote an interparadigmatic debate to arouse greater awareness on the subject and more robust consideration of such issues by future researchers.

  10. Ethical issues in HIV prevention research with people who inject drugs.

    Science.gov (United States)

    Sugarman, Jeremy; Rose, Scott M; Metzger, David

    2014-04-01

    Injection drug use continues to significantly contribute to new infections with HIV. Moreover, conducting HIV prevention research with people who inject drugs (PWIDs) can be complicated for an array of practical, social, legal, and ethical reasons. It is critical that these research efforts are sensitive to the particular vulnerabilities associated with injection drug use as well as those related to being at risk of acquiring HIV so as to minimize harm to participants in research. To describe how we addressed some of these ethical challenges during the course of a large-scale multinational randomized HIV prevention trial involving PWIDs, which was successfully completed. The ethical issues encountered during the life cycle of the trial were cataloged by the principal investigator, study coordinator, and ethicist working on the trial. Relevant study documents were then reviewed to provide pertinent details. The ethical issues unique to the trial were then described. Before implementation, the trial faced particularly complex challenges related to the vulnerability of PWIDs, where HIV seroincidence rates in the population were high and legal policies and stigma regarding injection drug use was severe. Accordingly, a rapid policy assessment was commissioned, and a series of community engagement activities were conducted. During the trial, in addition to using careful standard operating procedures regarding all aspects of trial conduct and extensive staff training, the trial standardized informed consent procedures and assessed them. Furthermore, social harms were monitored along with physical harms and adverse events. Following the decision to close the study, it was critical to develop an orderly and safe process for closing it. The issue of post-trial access to the study medication and a complex intervention also surfaced for consideration. The issues described in this article are necessarily limited to how they manifested themselves within the context of a

  11. New experimental research stand SVICKA neutron field analysis using neutron activation detector technique

    Science.gov (United States)

    Varmuza, Jan; Katovsky, Karel; Zeman, Miroslav; Stastny, Ondrej; Haysak, Ivan; Holomb, Robert

    2018-04-01

    Knowledge of neutron energy spectra is very important because neutrons with various energies have a different material impact or a biological tissue impact. This paper presents basic results of the neutron flux distribution inside the new experimental research stand SVICKA which is located at Brno University of Technology in Brno, Czech Republic. The experiment also focused on the investigation of the sandwich biological shielding quality that protects staff against radiation effects. The set of indium activation detectors was used to the investigation of neutron flux distribution. The results of the measurement provide basic information about the neutron flux distribution inside all irradiation channels and no damage or cracks are present in the experimental research stand biological shielding.

  12. Lines of experimental research in developing mathematical models for estimating internal radiation

    International Nuclear Information System (INIS)

    Bad'in, V.I.; Ermilov, A.P.; Margulis, U.Ya.; Khrushch, V.T.

    The report presents material involved with the statistical approach to the problem of modeling internal radiation and the trend of experimental research dictated by that approach. The content of a radioactive isotope in an organ must be viewed as a random function for which the ratio of two independent incorporations, on the average by probability, corresponds to the ratio of the corresponding amounts of the isotope that have accumulated in the organism. This tenet determines the principle of similarity. Specifically, it follows from it that the distribution of the arbitrary amount in the organism with multiple repetition of the experiment will be subordinate to a log-normal law. Second, the vital condition for creating the quantitative statistical model of the metabolism is a large volume of experimental data. This requires perfection of the unified rapid methods of research

  13. Experimental Research into Technology of Abrasive Flow Machining Nonlinear Tube Runner

    Directory of Open Access Journals (Sweden)

    Junye Li

    2014-06-01

    Full Text Available In the fields of military and civil uses, some special passages exist in many major parts, such as non-linear tubes. The overall performance is usually decided by the surface quality. Abrasive flow machining (AFM technology can effectively improve the surface quality of the parts. In order to discuss the mechanism and technology of abrasive flow machining nonlinear tube, the nozzle is picked up as the researching object, and the self-designed polishing liquid is employed to make research on the key technological parameters of abrasive flow machining linear tube. Technological parameters’ impact on surface quality of the parts through the nozzle surface topography and scanning electron microscopy (SEM map is explored. It is experimentally confirmed that abrasive flow machining can significantly improve surface quality of nonlinear runner, and experimental results can provide technical reference to optimizing study of abrasive flow machining theory.

  14. Experimental medical mycological research in Latin America - a 2000-2009 overview.

    Science.gov (United States)

    San-Blas, Gioconda; Burger, Eva

    2011-01-01

    An overview of current trends in Latin American Experimental Medical Mycological research since the beginning of the 21(st) century is done (search from January 2000 to December 2009). Using the PubMed and LILACS databases, the authors have chosen publications on medically important fungi which, according to our opinion, are the most relevant because of their novelty, interest, and international impact, based on research made entirely in the Latin American region or as part of collaborative efforts with laboratories elsewhere. In this way, the following areas are discussed: 1) molecular identification of fungal pathogens; 2) molecular and clinical epidemiology on fungal pathogens of prevalence in the region; 3) cell biology; 4) transcriptome, genome, molecular taxonomy and phylogeny; 5) immunology; 6) vaccines; 7) new and experimental antifungals. Copyright © 2010 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

  15. Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.

    Science.gov (United States)

    Reinero, Carol R; Decile, Kendra C; Byerly, Jenni R; Berghaus, Roy D; Walby, William E; Berghaus, Londa J; Hyde, Dallas M; Schelegle, Edward S; Gershwin, Laurel J

    2005-07-01

    To compare the effects of an orally administered corticosteroid (prednisone), an inhaled corticosteroid (flunisolide), a leukotriene-receptor antagonist (zafirlukast), an antiserotonergic drug (cyproheptadine), and a control substance on the asthmatic phenotype in cats with experimentally induced asthma. 6 cats with asthma experimentally induced by the use of Bermuda grass allergen (BGA). A randomized, crossover design was used to assess changes in the percentage of eosinophils in bronchoalveolar lavage fluid (BALF); airway hyperresponsiveness; blood lymphocyte phenotype determined by use of flow cytometry; and serum and BALF content of BGA-specific IgE, IgG, and IgA determined by use of ELISAs. Mean +/- SE eosinophil percentages in BALF when cats were administered prednisone (5.0 +/- 2.3%) and flunisolide (2.5 +/- 1.7%) were significantly lower than for the control treatment (33.7 +/- 11.1%). We did not detect significant differences in airway hyperresponsiveness or lymphocyte surface markers among treatments. Content of BGA-specific IgE in serum was significantly lower when cats were treated with prednisone (25.5 +/- 5.4%), compared with values for the control treatment (63.6 +/- 12.9%); no other significant differences were observed in content of BGA-specific immunoglobulins among treatments. Orally administered and inhaled corticosteroids decreased eosinophilic inflammation in airways of cats with experimentally induced asthma. Only oral administration of prednisone decreased the content of BGA-specific IgE in serum; no other significant local or systemic immunologic effects were detected among treatments. Inhaled corticosteroids can be considered as an alternate method for decreasing airway inflammation in cats with asthma.

  16. Experimental research on the residual mechanical properties of an ordinary concretes after fire

    OpenAIRE

    Santos, C.C.; Rodrigues, J.P.

    2015-01-01

    This paper summarizes the results of an experimental research to assess the residual mechanical properties of an ordinary concrete after fire. It was studied the influence of the cooling process, the maximum temperature that the concrete was subjected to and the loading level on the residual mechanical properties of calcareous and granite aggregate concretes. The properties studied were the residual compressive, tensile, splitting and flexural strengths and modulus of elasticit...

  17. Experimental research on the durability cutting tools for cutting-off steel profiles

    Directory of Open Access Journals (Sweden)

    Cristea Alexandru

    2017-01-01

    Full Text Available The production lines used for manufacturing U-shaped profiles are very complex and they must have high productivity. One of the most important stages of the fabrication process is the cutting-off. This paper presents the experimental research and analysis of the durability of the cutting tools used for cutting-off U-shaped metal steel profiles. The results of this work can be used to predict the durability of the cutting tools.

  18. Experimental and modeling studies of fire in compartments at Electricite de France, Research and Development Division

    International Nuclear Information System (INIS)

    Gautier, B.

    1997-12-01

    Since 1985, The Research and Development Division at Electricite de France has been in charge, through the development of the software MAGIC, to simulate the fire propagation in Nuclear Plants. The research program has included, since its beginning, an experimental activity dedicated to the combustion of fluids and electrical cables. This paper gives an overview of the works in progress and presents the latest results obtained, in particular in cable combustion. In this field, a three scale approach has been carried on, based on micro-thermo-gravimetry, calorimetry and real scale experiments. (author)

  19. National Institute on Drug Abuse International Program: improving opioid use disorder treatment through international research training.

    Science.gov (United States)

    Gust, Steven W; McCormally, Judy

    2018-07-01

    For more than 25 years, the National Institute on Drug Abuse (NIDA) has supported research-training programs, establishing a global research network and expanding the knowledge base on substance use disorders. International research to inform approaches to opioid addiction is particularly important and relevant to the United States, where opioid misuse, addiction, and overdose constitute an emerging public health crisis. This article summarizes the NIDA International Program and illustrates its impact by reviewing recent articles about treatment approaches for opioid use disorders (OUD). Studies in several countries have demonstrated the effectiveness of physician office-based opioid substitution therapies. Other research has demonstrated the effectiveness of different formulations and doses of the opioid antagonist naltrexone, as well as different approaches to providing naloxone to treat opioid overdose. Continuing research into implementation of evidence-based treatment in international settings with limited resources is applicable to US regions that face similar structural, legal, and fiscal constraints. The current review describes international research on OUD treatment and opioid overdose, most coauthored by former NIDA fellows. The findings from outside the United States have important implications for best practices domestically and in other countries that are experiencing increases in OUD prevalence and related overdose deaths.

  20. A review of geographic variation and Geographic Information Systems (GIS) applications in prescription drug use research.

    Science.gov (United States)

    Wangia, Victoria; Shireman, Theresa I

    2013-01-01

    While understanding geography's role in healthcare has been an area of research for over 40 years, the application of geography-based analyses to prescription medication use is limited. The body of literature was reviewed to assess the current state of such studies to demonstrate the scale and scope of projects in order to highlight potential research opportunities. To review systematically how researchers have applied geography-based analyses to medication use data. Empiric, English language research articles were identified through PubMed and bibliographies. Original research articles were independently reviewed as to the medications or classes studied, data sources, measures of medication exposure, geographic units of analysis, geospatial measures, and statistical approaches. From 145 publications matching key search terms, forty publications met the inclusion criteria. Cardiovascular and psychotropic classes accounted for the largest proportion of studies. Prescription drug claims were the primary source, and medication exposure was frequently captured as period prevalence. Medication exposure was documented across a variety of geopolitical units such as countries, provinces, regions, states, and postal codes. Most results were descriptive and formal statistical modeling capitalizing on geospatial techniques was rare. Despite the extensive research on small area variation analysis in healthcare, there are a limited number of studies that have examined geographic variation in medication use. Clearly, there is opportunity to collaborate with geographers and GIS professionals to harness the power of GIS technologies and to strengthen future medication studies by applying more robust geospatial statistical methods. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Status of the INL high-temperature electrolysis research program –experimental and modeling

    Energy Technology Data Exchange (ETDEWEB)

    J. E. O' Brien; C. M. Stoots; M. G. McKellar; E. A. Harvego; K. G. Condie; G. K. Housley; J. S. Herring; J. J. Hartvigsen

    2009-04-01

    This paper provides a status update on the high-temperature electrolysis (HTE) research and development program at the Idaho National Laboratory (INL), with an overview of recent large-scale system modeling results and the status of the experimental program. System analysis results have been obtained using the commercial code UniSim, augmented with a custom high-temperature electrolyzer module. The process flow diagrams for the system simulations include an advanced nuclear reactor as a source of high-temperature process heat, a power cycle and a coupled steam electrolysis loop. Several reactor types and power cycles have been considered, over a range of reactor coolant outlet temperatures. In terms of experimental research, the INL has recently completed an Integrated Laboratory Scale (ILS) HTE test at the 15 kW level. The initial hydrogen production rate for the ILS test was in excess of 5000 liters per hour. Details of the ILS design and operation will be presented. Current small-scale experimental research is focused on improving the degradation characteristics of the electrolysis cells and stacks. Small-scale testing ranges from single cells to multiple-cell stacks. The INL is currently in the process of testing several state-of-the-art anode-supported cells and is working to broaden its relationship with industry in order to improve the long-term performance of the cells.

  2. Haunted thoughts of the careful experimentalist: psychical research and the troubles of experimental physics.

    Science.gov (United States)

    Noakes, Richard

    2014-12-01

    This paper analyses the relationship between the 'elusive' science of psychical research and experimental physics in the period approximately, 1870-1930. Most studies of the relationship between psychical research and the established sciences have examined the ways in which psychical researchers used theories in the established sciences to give greater plausibility to their interpretations of such puzzling phenomena as telepathy, telekinesis and ectoplasm. A smaller literature has examined the use of laboratory instruments to produce scientific evidence for these phenomena. This paper argues that the cultures of experiment in the established science of physics could matter to psychical research in a different way: it suggests that experience of capricious effects, recalcitrant instruments and other problems of the physical laboratory made British physicists especially sympathetic towards the difficulties of the spiritualistic séance and other sites of psychical enquiry. In the wake of widely-reported claims that the mediums they had investigated had been exposed as frauds, these scientific practitioners were eventually persuaded by the merits of an older argument that human psychic subjects could not be treated like laboratory hardware. However, well into the twentieth century, they maintained that experimental physics had important lessons for psychical researchers. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. The Joint Institute for Nuclear Research in Experimental Physics of Elementary Particles

    Science.gov (United States)

    Bednyakov, V. A.; Russakovich, N. A.

    2018-05-01

    The year 2016 marks the 60th anniversary of the Joint Institute for Nuclear Research (JINR) in Dubna, an international intergovernmental organization for basic research in the fields of elementary particles, atomic nuclei, and condensed matter. Highly productive advances over this long road clearly show that the international basis and diversity of research guarantees successful development (and maintenance) of fundamental science. This is especially important for experimental research. In this review, the most significant achievements are briefly described with an attempt to look into the future (seven to ten years ahead) and show the role of JINR in solution of highly important problems in elementary particle physics, which is a fundamental field of modern natural sciences. This glimpse of the future is full of justified optimism.

  4. Does rosmarinic acid underestimate as an experimental cardiovascular drug? Seria o ácido rosmarínico subestimado como droga cardiovascular experimental?

    Directory of Open Access Journals (Sweden)

    Luciana Garros Ferreira

    2013-01-01

    Full Text Available PURPOSE: The rationale of the present review is to analize the activity of Rosmarinus officinalis in the the cardiovascular system METHODS: A MEDLINE database search (from January 1970 to December 2011 using only rosmarinic acid as searched term. RESULTS: The references search revealed 509 references about rosmarinic acid in 40 years (the first reference is from 1970. There is a powerful prevalence of antioxidant and cancer studies. Other diseases are few cited, as inflammation, brain (Alzheimer and Parkinson disease and, memory; allergy; diabetes; atherosclerosis, and; hypertension. It is necessary to consider the complete absence of studies on coronary artery disease, myocardial ischemia, heart failure or ischemia/reperfusion injury. CONCLUSION: Rosmarinic acid is underestimated as an experimental cardiovascular drug and deserves more attention.OBJETIVO: A justificativa da revisão é analisar a atividade de Rosmarinus officinalis no sistema cardiovascular MÉTODOS: Uma busca de banco de dados MEDLINE (de janeiro de 1970 a dezembro de 2011, utilizando apenas o ácido rosmarínico como termo pesquisado. RESULTADOS: A busca referências revelou 509 referências sobre o ácido rosmarínico em 40 anos (a primeira referência é de 1970. Há uma prevalência poderoso antioxidante e estudos do câncer. Outras doenças são citados alguns, como o cérebro, inflamação (de Alzheimer e doença de Parkinson e, a memória, hipertensão, alergia, diabetes, aterosclerose, e. É necessário ter em conta a ausência completa de estudos sobre a doença de artéria coronária, isquemia do miocárdio, insuficiência cardíaca ou isquemia / lesão de reperfusão. CONCLUSÃO: O ácido rosmarínico é subestimado como uma droga experimental cardiovascular e merece mais atenção.

  5. Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals.

    Science.gov (United States)

    Hoerauf, Janine M; Moss, Angela F; Fernandez-Bustamante, Ana; Bartels, Karsten

    2018-01-01

    Lack of reproducibility of preclinical studies has been identified as an impediment for translation of basic mechanistic research into effective clinical therapies. Indeed, the National Institutes of Health has revised its grant application process to require more rigorous study design, including sample size calculations, blinding procedures, and randomization steps. We hypothesized that the reporting of such metrics of study design rigor has increased over time for animal-experimental research published in anesthesia journals. PubMed was searched for animal-experimental studies published in 2005, 2010, and 2015 in primarily English-language anesthesia journals. A total of 1466 publications were graded on the performance of sample size estimation, randomization, and blinding. Cochran-Armitage test was used to assess linear trends over time for the primary outcome of whether or not a metric was reported. Interrater agreement for each of the 3 metrics (power, randomization, and blinding) was assessed using the weighted κ coefficient in a 10% random sample of articles rerated by a second investigator blinded to the ratings of the first investigator. A total of 1466 manuscripts were analyzed. Reporting for all 3 metrics of experimental design rigor increased over time (2005 to 2010 to 2015): for power analysis, from 5% (27/516), to 12% (59/485), to 17% (77/465); for randomization, from 41% (213/516), to 50% (243/485), to 54% (253/465); and for blinding, from 26% (135/516), to 38% (186/485), to 47% (217/465). The weighted κ coefficients and 98.3% confidence interval indicate almost perfect agreement between the 2 raters beyond that which occurs by chance alone (power, 0.93 [0.85, 1.0], randomization, 0.91 [0.85, 0.98], and blinding, 0.90 [0.84, 0.96]). Our hypothesis that reported metrics of rigor in animal-experimental studies in anesthesia journals have increased during the past decade was confirmed. More consistent reporting, or explicit justification for absence

  6. Development and validation of a general approach to predict and quantify the synergism of anti-cancer drugs using experimental design and artificial neural networks.

    Science.gov (United States)

    Pivetta, Tiziana; Isaia, Francesco; Trudu, Federica; Pani, Alessandra; Manca, Matteo; Perra, Daniela; Amato, Filippo; Havel, Josef

    2013-10-15

    The combination of two or more drugs using multidrug mixtures is a trend in the treatment of cancer. The goal is to search for a synergistic effect and thereby reduce the required dose and inhibit the development of resistance. An advanced model-free approach for data exploration and analysis, based on artificial neural networks (ANN) and experimental design is proposed to predict and quantify the synergism of drugs. The proposed method non-linearly correlates the concentrations of drugs with the cytotoxicity of the mixture, providing the possibility of choosing the optimal drug combination that gives the maximum synergism. The use of ANN allows for the prediction of the cytotoxicity of each combination of drugs in the chosen concentration interval. The method was validated by preparing and experimentally testing the combinations with the predicted highest synergistic effect. In all cases, the data predicted by the network were experimentally confirmed. The method was applied to several binary mixtures of cisplatin and [Cu(1,10-orthophenanthroline)2(H2O)](ClO4)2, Cu(1,10-orthophenanthroline)(H2O)2(ClO4)2 or [Cu(1,10-orthophenanthroline)2(imidazolidine-2-thione)](ClO4)2. The cytotoxicity of the two drugs, alone and in combination, was determined against human acute T-lymphoblastic leukemia cells (CCRF-CEM). For all systems, a synergistic effect was found for selected combinations. © 2013 Elsevier B.V. All rights reserved.

  7. Gender bias in clinical research, pharmaceutical marketing, and the prescription of drugs

    Directory of Open Access Journals (Sweden)

    Elisa Chilet-Rosell

    2014-12-01

    Full Text Available This thesis is part of the studies of gender bias in health which together with the paradigm of evidence-based medicine shares the empirical assumption that there are inaccuracies in medical practice, in addition to a lack of rigour and transparency. It worked with the distinction between the concepts of sex and gender and between the concepts of sex-related differences and gender inequalities, in terms of applying a gender perspective in the study design and the subsequent analysis. This PhD review presents the research process conducted in Spain, which can provide an example for future research. Study I described a review of 58 clinical trials (CTs of etoricoxib to assess its compliance with the Recommendations of Evaluation of Gender Differences in the Clinical Evaluation of Drugs. In Study II, key informants from professions related to different areas in drug development and pharmacovigilance held a working meeting to reach a consensus document on recommendations for the study and evaluation of gender differences in CTs in Spain. In Study III, the websites of the eight best-selling hormone replacement therapy drugs in Spain on Google first page of results were analysed. In Study IV, a logistic regression analysis was performed to compare analgesic prescription by sex in regions with a higher or lower Gender Development Index (GDI than the Spanish average. Gender biases identified in this thesis limited the legitimacy of medicine, which is not based on the best possible evidence. The results also demonstrate the existence of inequalities between men and women that are not due merely to biological differences, but are gender inequalities stemming from the social differences that exist between both sexes.

  8. Gender bias in clinical research, pharmaceutical marketing, and the prescription of drugs.

    Science.gov (United States)

    Chilet-Rosell, Elisa

    2014-01-01

    This thesis is part of the studies of gender bias in health which together with the paradigm of evidence-based medicine shares the empirical assumption that there are inaccuracies in medical practice, in addition to a lack of rigour and transparency. It worked with the distinction between the concepts of sex and gender and between the concepts of sex-related differences and gender inequalities, in terms of applying a gender perspective in the study design and the subsequent analysis. This PhD review presents the research process conducted in Spain, which can provide an example for future research. Study I described a review of 58 clinical trials (CTs) of etoricoxib to assess its compliance with the Recommendations of Evaluation of Gender Differences in the Clinical Evaluation of Drugs. In Study II, key informants from professions related to different areas in drug development and pharmacovigilance held a working meeting to reach a consensus document on recommendations for the study and evaluation of gender differences in CTs in Spain. In Study III, the websites of the eight best-selling hormone replacement therapy drugs in Spain on Google first page of results were analysed. In Study IV, a logistic regression analysis was performed to compare analgesic prescription by sex in regions with a higher or lower Gender Development Index (GDI) than the Spanish average. Gender biases identified in this thesis limited the legitimacy of medicine, which is not based on the best possible evidence. The results also demonstrate the existence of inequalities between men and women that are not due merely to biological differences, but are gender inequalities stemming from the social differences that exist between both sexes.

  9. Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research.

    Science.gov (United States)

    Hook, Vivian Y H

    2006-01-01

    The nervous system represents a key area for development of novel therapeutic agents for the treatment of neurological and neurodegenerative diseases. Recent research has demonstrated the critical importance of neuroproteases for the production of specific peptide neurotransmitters and for the production of toxic peptides in major neurodegenerative diseases that include Alzheimer, Huntington, and Parkinson diseases. This review illustrates the successful criteria that have allowed identification of proteases responsible for converting protein precursors into active peptide neurotransmitters, consisting of dual cysteine protease and subtilisin-like protease pathways in neuroendocrine cells. These peptide neurotransmitters are critical regulators of neurologic conditions, including analgesia and cognition, and numerous behaviors. Importantly, protease pathways also represent prominent mechanisms in neurodegenerative diseases, especially Alzheimer, Huntington, and Parkinson diseases. Recent studies have identified secretory vesicle cathepsin B as a novel beta-secretase for production of the neurotoxic beta-amyloid (Abeta) peptide of Alzheimer disease. Moreover, inhibition of cathepsin B reduces Abeta peptide levels in brain. These neuroproteases potentially represent new drug targets that should be explored in future pharmaceutical research endeavors for drug discovery.

  10. Research progress of PARP-1 inhibitors in antitumor drugs and radionuclide markers

    International Nuclear Information System (INIS)

    Zhao Lingzhou; Zhang Huabei

    2011-01-01

    Poly(ADP-ribose)polymerase (PARP) is a new target in the cancer treatment nowadays. PARP not only can repair DNA damage, regulate and control transcription, maintain the stability of intracellular environment and genome, regulate the process of cell survival and death, but also is the main transcription factor in the development of inflammation and the process of cancer. To inhibit PARP activity can reduce the DNA repair function in tumor cells, and increase the sensibility to DNA damage agents, so as to improve the efficacy of radiation therapy and chemotherapy for tumor. A number of studies have suggested that, whether used alone or combination with other chemotherapy drugs, PARP inhibitors show the potential in the anti-tumor therapeutic areas. In this paper, PARP-1 inhibitors were reviewed in antitumor research progress. According to the stage of development , PARP-1 inhibitors are classified. Several representative PARP-1 inhibitors, in clinical trials, with potential clinical value were introduced. Positron emission tomography (PET), uses the main short half-life elementary in human body as tracer, and at the molecular level, achieve the no wound, quantitative and dynamic observation about the different changes of metabolites or drugs in the body. PET is the most advanced contemporary video diagnostic technology, and this paper simply introduce the research progress of PARP-1 inhibitors labeled with radioactive nuclides. (authors)

  11. Research coordination meeting of the coordinated research project on analytical and experimental benchmark analyses of accelerator driven systems. Working material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The Technical Meeting hosted at the Belarus National Academy of Sciences in Minsk by the Joint Institute of Power Engineering and Nuclear Research 'SOSNY' from 5-9 December 2005 was the kick-off Research Coordination Meeting (RCM) of the IAEA Coordinated Research Project (CRP) on 'Analytical and Experimental Benchmark Analyses of Accelerator Driven Systems (ADS)'. The CRP had received proposals for research agreements and contracts from scientists representing the following 25 institutions: Centro Atomico Bariloche, SCK CEN Mol, Instituto de Pesquisas Energeticas e Nucleares Sao Paulo, Joint Institute of Power Engineering and Nuclear Research SOSNY Minsk, China Institute of Atomic Energy, CEA Cadarache, CNRS Paris, FZ Rossendorf, FZ Karlsruhe, Budapest University of Technology and Economics, Politecnico di Torino, Japan Atomic Energy Agency, Nuclear Research and Consultancy Group (NRG) Petten, Pakistan Institute of Nuclear Science and Technology, AGH-University of Science and Technology Krakow, Institute of Atomic Energy Otwock/Swierk, ITEP Moscow, MEPHI Moscow, Kurchatov Institute, JINR Dubna, Universidad Politecnica de Madrid, CIEMAT Madrid, Royal Institute of Technology Stockholm, National Science Center 'Kharkov Institute and Technology', and Argonne National Laboratory). These institutions represent 18 IAEA Member States (i.e., Argentina, Belarus, Belgium, Brazil, China, France, Germany, Hungary, Italy, Japan, Netherlands, Pakistan, Poland, Russia, Spain, Sweden, Ukraine, USA), and one International Organization (JINR Dubna). The overall objective of the CRP is contributing to the generic R and D efforts in various fields common to innovative fast neutron system development, i.e., heavy liquid metal thermal hydraulics, dedicated transmutation fuels and associated core designs, theoretical nuclear reaction models, measurement and evaluation of nuclear data for transmutation, and development and validation of calculational methods and codes. Ultimately, the CRP

  12. Chiral drug analysis using mass spectrometric detection relevant to research and practice in clinical and forensic toxicology.

    Science.gov (United States)

    Schwaninger, Andrea E; Meyer, Markus R; Maurer, Hans H

    2012-12-21

    This paper reviews analytical approaches published in 2002-2012 for chiral drug analysis and their relevance in research and practice in the field of clinical and forensic toxicology. Separation systems such as gas chromatography, high performance liquid chromatography, capillary electromigration, and supercritical fluid chromatography, all coupled to mass spectrometry, are discussed. Typical applications are reviewed for relevant chiral analytes such as amphetamines and amphetamine-derived designer drugs, methadone, tramadol, psychotropic and other CNS acting drugs, anticoagulants, cardiovascular drugs, and some other drugs. Usefulness of chiral drug analysis in the interpretation of analytical results in clinical and forensic toxicology is discussed as well. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Ethical issues associated with the use of animal experimentation in behavioral neuroscience research.

    Science.gov (United States)

    Ohl, Frauke; Meijboom, Franck

    2015-01-01

    This chapter briefly explores whether there are distinct characteristics in the field of Behavioral Neuroscience that demand specific ethical reflection. We argue that although the ethical issues in animal-based Behavioral Neuroscience are not necessarily distinct from those in other research disciplines using animal experimentation, this field of endeavor makes a number of specific, ethically relevant, questions more explicit and, as a result, may expose to discussion a series of ethical issues that have relevance beyond this field of science. We suggest that innovative research, by its very definition, demands out-of-the-box thinking. At the same time, standardization of animal models and test procedures for the sake of comparability across experiments inhibits the potential and willingness to leave well-established tracks of thinking, and leaves us wondering how open minded research is and whether it is the researcher's established perspective that drives the research rather than the research that drives the researcher's perspective. The chapter finishes by introducing subsequent chapters of this book volume on Ethical Issues in Behavioral Neuroscience.

  14. Experimental research of kinetic and dynamic characteristics of temperature movements of machines

    Science.gov (United States)

    Parfenov, I. V.; Polyakov, A. N.

    2018-03-01

    Nowadays, the urgency of informational support of machines at different stages of their life cycle is increasing in the form of various experimental characteristics that determine the criteria for working capacity. The effectiveness of forming the base of experimental characteristics of machines is related directly to the duration of their field tests. In this research, the authors consider a new technique that allows reducing the duration of full-scale testing of machines by 30%. To this end, three new indicator coefficients were calculated in real time to determine the moments corresponding to the characteristic points. In the work, new terms for thermal characteristics of machine tools are introduced: kinetic and dynamic characteristics of the temperature movements of the machine. This allow taking into account not only the experimental values for the temperature displacements of the elements of the carrier system of the machine, but also their derivatives up to the third order, inclusively. The work is based on experimental data obtained in the course of full-scale thermal tests of a drilling-milling and boring CNC machine.

  15. Experimental research on heat transfer performance of supercritical water in vertical tube

    International Nuclear Information System (INIS)

    Wang Fei; Yang Jue; Li Hongbo; Lu Donghua; Gu Hanyang; Zhao Meng

    2013-01-01

    Experimental research under supercritical pressure conditions was carried out on heat transfer performance in vertical tube of φ10 mm with a wide range of experimental parameters. The impacts of heat flux, mass flow rate and pressure on wall temperature and heat transfer coefficient were investigated. The experimental parameters are following: The pressures are 23, 25, 26 MPa, the mass flow rate range is 450 1200 kg/(m 2 ·s), and the heat flux range is 200-1200 kW/m 2 . Experimental results indicate that the wall temperature gradually increases with the bulk temperature, and heat transfer enhancement exists near the critical temperature as the drastic changes in physical properties. The increase in heat flux and the decrease in mass flow rate reduce heat transfer enhancement and lead to deterioration of heat transfer. The main effects of pressure are reflected in the difference of heat flux and bulk temperature of the start point where heat transfer deterioration and enhancement occur. (authors)

  16. An Introduction to Sensitivity Analysis for Unobserved Confounding in Non-Experimental Prevention Research

    Science.gov (United States)

    Kuramoto, S. Janet; Stuart, Elizabeth A.

    2013-01-01

    Despite that randomization is the gold standard for estimating causal relationships, many questions in prevention science are left to be answered through non-experimental studies often because randomization is either infeasible or unethical. While methods such as propensity score matching can adjust for observed confounding, unobserved confounding is the Achilles heel of most non-experimental studies. This paper describes and illustrates seven sensitivity analysis techniques that assess the sensitivity of study results to an unobserved confounder. These methods were categorized into two groups to reflect differences in their conceptualization of sensitivity analysis, as well as their targets of interest. As a motivating example we examine the sensitivity of the association between maternal suicide and offspring’s risk for suicide attempt hospitalization. While inferences differed slightly depending on the type of sensitivity analysis conducted, overall the association between maternal suicide and offspring’s hospitalization for suicide attempt was found to be relatively robust to an unobserved confounder. The ease of implementation and the insight these analyses provide underscores sensitivity analysis techniques as an important tool for non-experimental studies. The implementation of sensitivity analysis can help increase confidence in results from non-experimental studies and better inform prevention researchers and policymakers regarding potential intervention targets. PMID:23408282

  17. IAEA coordinated research project (CRP) on 'Analytical and experimental benchmark analyses of accelerator driven systems'

    International Nuclear Information System (INIS)

    Abanades, Alberto; Aliberti, Gerardo; Gohar, Yousry; Talamo, Alberto; Bornos, Victor; Kiyavitskaya, Anna; Carta, Mario; Janczyszyn, Jerzy; Maiorino, Jose; Pyeon, Cheolho; Stanculescu, Alexander; Titarenko, Yury; Westmeier, Wolfram

    2008-01-01

    In December 2005, the International Atomic Energy Agency (IAEA) has started a Coordinated Research Project (CRP) on 'Analytical and Experimental Benchmark Analyses of Accelerator Driven Systems'. The overall objective of the CRP, performed within the framework of the Technical Working Group on Fast Reactors (TWGFR) of IAEA's Nuclear Energy Department, is to increase the capability of interested Member States in developing and applying advanced reactor technologies in the area of long-lived radioactive waste utilization and transmutation. The specific objective of the CRP is to improve the present understanding of the coupling of an external neutron source (e.g. spallation source) with a multiplicative sub-critical core. The participants are performing computational and experimental benchmark analyses using integrated calculation schemes and simulation methods. The CRP aims at integrating some of the planned experimental demonstration projects of the coupling between a sub-critical core and an external neutron source (e.g. YALINA Booster in Belarus, and Kyoto University's Critical Assembly (KUCA)). The objective of these experimental programs is to validate computational methods, obtain high energy nuclear data, characterize the performance of sub-critical assemblies driven by external sources, and to develop and improve techniques for sub-criticality monitoring. The paper summarizes preliminary results obtained to-date for some of the CRP benchmarks. (authors)

  18. Basic versus applied research: Julius Sachs (1832-1897) and the experimental physiology of plants.

    Science.gov (United States)

    Kutschera, Ulrich

    2015-01-01

    The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This "plant-microbe-view" of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845-1920), so that the term "Sachs-Pfeffer-Principle of Experimental Plant Research" appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria).

  19. Experimental Research in Operation Management in Engine Room by using Language Sentiment/Opinion Analysis

    Directory of Open Access Journals (Sweden)

    Dimitris Papachristos

    2014-12-01

    Full Text Available The paper argues for the necessity of a combination MMR methods (questionnaire, interview and sentiment/opinion techniques to personal satisfaction analysis at the maritime and training education and proposes a generic, but practical research approach for this purpose. The proposed approach concerns the personal satisfaction evaluation of Engine Room simulator systems and combines the speech recording (sentiment/opinion analysis for measuring emotional user responses with usability testing (SUS tool. The experimental procedure presented here is a primary effort to research the emotion analysis (satisfaction of the users-students in Engine Room Simulators. Finally, the ultimate goal of this research is to find and test the critical factors that influence the educational practice and user’s satisfaction of Engine Room Simulator Systems and the ability to conduct full-time system control by the marine crew.

  20. Aerodynamic Research of the Experimental Prototype of the Variable Geometry Wind Turbine

    Directory of Open Access Journals (Sweden)

    Urbahs Aleksandrs

    2017-12-01

    Full Text Available The aim of this research is to develop a vertical rotation axis variable geometry wind turbine (WT. The experimental prototype is being manufactured with the help of CAM (Computer-aided manufacturing technologies – computer-based preparation of the product manufacturing process. The Institute of Aeronautics of Riga Technical University is using CNC (Computer Numerical Control machines for manufacturing the innovative WT and its components. The aerodynamic research has been done in T-4 wind tunnel at an air flow rate from 5 m/s to 30 m/s. The power increase of the variable geometry WT is a topical issue. Installation of such WTs in wind farms is possible and is subject to further research.

  1. Risk assessment and experimental design in the development of a prolonged release drug delivery system with paliperidone

    Directory of Open Access Journals (Sweden)

    Iurian S

    2017-03-01

    Full Text Available Sonia Iurian, Luana Turdean, Ioan Tomuta Department of Pharmaceutical Technology and Biopharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania Abstract: This study focuses on the development of a drug product based on a risk assessment-based approach, within the quality by design paradigm. A prolonged release system was proposed for paliperidone (Pal delivery, containing Kollidon® SR as an insoluble matrix agent and hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC, or sodium carboxymethyl cellulose as a hydrophilic polymer. The experimental part was preceded by the identification of potential sources of variability through Ishikawa diagrams, and failure mode and effects analysis was used to deliver the critical process parameters that were further optimized by design of experiments. A D-optimal design was used to investigate the effects of Kollidon SR ratio (X1, the type of hydrophilic polymer (X2, and the percentage of hydrophilic polymer (X3 on the percentages of dissolved Pal over 24 h (Y1–Y9. Effects expressed as regression coefficients and response surfaces were generated, along with a design space for the preparation of a target formulation in an experimental area with low error risk. The optimal formulation contained 27.62% Kollidon SR and 8.73% HPMC and achieved the prolonged release of Pal, with low burst effect, at ratios that were very close to the ones predicted by the model. Thus, the parameters with the highest impact on the final product quality were studied, and safe ranges were established for their variations. Finally, a risk mitigation and control strategy was proposed to assure the quality of the system, by constant process monitoring. Keywords: pharmaceutical development, quality by design, failure mode effects analysis, Ishikawa diagram, fish-bone diagram, hydrophilic matrix

  2. Experimentations queer in a research about production of femininities in “trans bodies”

    Directory of Open Access Journals (Sweden)

    Thaissa Vasconcelos

    2016-07-01

    Full Text Available In this article, we analyze some aspects about otherness, addressing the body not like a materiality, but above all in their properties affectations and possibilities. These reflections are presented based on an experimentation, developed in the course of development of a master's thesis, which was the experience of “se montar” by the researcher (registered at birth as female. Through this experimentation and subsequent dialogues about it, we discussed the limits and possibilities of a Queer theoretical body, entering on questions of production dimorphic model of bodies, the heteronorm, and intelligibility that produces viable (or not some bodies. In this process still we are discussing issues relating to the abjection and gender as performativity.

  3. Experimental research on velocity distribution in narrow slots of plane type reactor fuel

    International Nuclear Information System (INIS)

    Qu Xinxing; Zhang Youjie; Jia Haijun; Jiang Shengyao; Bo Hanliang; Min Gang

    2003-01-01

    The experimental research on velocity distribution in multiple parallel narrow channels formed by fuel plane of assembly is carried out under various Re and the water without ions as fluid in testing loop. The experimental results show that under various Re within a channel the velocity in the middle area is high and the velocity in the edge of channel decreases rapidly to zero, and the velocity is symmetrically distributed along the central line, thus the velocity distribution within a channel is like a trapezium. While in parallel channels the velocity of the middle channel is low and the velocity of the channel close to the edge is high, it is supposed to be caused by the inlet structure of channels, this concave distribution is a disadvantage to the even distribution of reactor flux

  4. A comparative study to investigate burnup in research reactor fuel using two independent experimental methods

    International Nuclear Information System (INIS)

    Iqbal, M.; Mehmood, T.; Ayazuddin, S.K.; Salahuddin, A.; Pervez, S.

    2001-01-01

    Two independent experimental methods have been used for the comparative study of fuel burnup measurement in low enriched uranium, plate type research reactor. In the first method a gamma ray activity ratio method was employed. An experimental setup was established for gamma ray scanning using prior calibrated high purity germanium detector. The computer software KORIGEN gave the theoretical support. In the second method reactivity difference technique was used. At the same location in the same core configuration the fresh and burned fuel element's reactivity worth was estimated. For theoretical estimated curve, group cross-sections were generated using computer code WIMS-D/4, and three dimensional modeling was made by computer code CITATION. The measured burnup of different fuel elements using these methods were found to be in good agreement

  5. Experimental research of inclined-micro-fin flat tube on single phase convection heat transfer

    International Nuclear Information System (INIS)

    Fan Guangming; Sun Zhongning; Wang Meng

    2011-01-01

    The experimental research of heat transfer and flow resistance characteristics of single phase water in four inclined-micro-fin flat tubes with different physical dimensions was conducted. At the same time,suitable criteria were selected to evaluate the efficiency of inclined-micro-fin flat tubes within the experimental scope and the optimal working region was determined. The results indicate that inclined-micro-fin flat tubes can greatly enhance the single-phase heat transfer in turbulent flow and the maximum heat transfer coefficient attains to 5.9 times of that in smooth tube. The quantities of heat transfer for inclined-micro-fin flat tubes are three times higher than that of smooth tube with the same of heat exchange area and pump power. (authors)

  6. Pushing the accelerator - speeding up drug research with accelerator mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Garner, R.C. E-mail: colin.garner@cbams.co.uk; Leong, D

    2000-10-01

    Accelerator mass spectrometry (AMS) is the most sensitive analytical method yet developed for elemental isotope analysis and has a broad range of applications. The measurement of {sup 14}C is of most interest to biomedical researchers but few studies have been reported using AMS in drug discovery and development. For biomedical use, {sup 14}C is incorporated into organic molecules by either radiosynthesis or biosynthetically and the isotope is used as a surrogate for the distribution of the radiolabelled molecule either in animal or human studies. The majority of users of {sup 14}C quantitate the radioactivity using decay counting usually with a liquid scintillation counter (LSC). Our Centre over the past 12 months has been evaluating and validating the use of AMS as an alternative detection method. In vitro spiking studies of human plasma with {sup 14}C-Fluconazole, a prescription antifungal drug has demonstrated an excellent correlation between AMS and LSC (correlation coefficient 0.999). Human Phase I clinical studies have been conducted with radioactive doses ranging from 120 Bq (7000 dpm) to 11 kBq (300 nCi) to provide mass balance, plasma concentration and radioactive metabolite profiling data. Limits of detection of 0.00022 Bq {sup 14}C-labelled drug/ml plasma have been accurately quantitated in a plasma background of 0.0078 Bq/ml (0.013 dpm/ml in a plasma background of 0.47 dpm/ml or 2.72 pMC in a background of 90.19 pMC)

  7. Experimental research in neutron physic and thermal-hydraulic at the CDTN Triga reactor

    Energy Technology Data Exchange (ETDEWEB)

    Mesquita, Amir Z.; Souza, Rose Mary G.P.; Ferreira, Andrea V.; Pinto, Antonio J.; Costa, Antonio C.L.; Rezende, Hugo C., E-mail: amir@cdtn.b, E-mail: souzarm@cdtn.b, E-mail: avf@cdtn.b, E-mail: ajp@cdtn.b, E-mail: aclc@cdtn.b, E-mail: hcr@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2011-07-01

    The IPR-R1 TRIGA (Training, Research, Isotopes production, General Atomics) at Nuclear Technology Development Center (CDTN) is a pool type reactor cooled by natural circulation of light water and an open surface. TRIGA reactors, developed by General Atomics (GA), are the most widely used research reactor in the world and characterized by inherent safety. The IPR-R1 is the only Brazilian nuclear research reactor available and able to perform experiments in which interaction between neutronic and thermal-hydraulic areas occurs. The IPR-R1 has started up on November 11th, 1960. At that time the maximum thermal power was 30 kW. The present forced cooling system was built in the 70th and the power was upgraded to 100 kW. Recently the core configuration and instrumentation was upgraded again to 250 kW at steady state, and is awaiting the license of CNEN to operate definitely at this new power. This paper describes the experimental research project carried out in the IPR-R1 reactor that has as objective evaluate the behaviour of the reactor operational parameters, and mainly to investigate the influence of temperature on the neutronic variables. The research was supported by Research Support Foundation of the State of Minas Gerais (FAPEMIG) and Brazilian Council for Scientific and Technological Development (CNPq). The research project meets the recommendations of the IAEA, for safety, modernization and development of strategic plan for research reactors utilization. This work is in line with the strategic objectives of Brazil, which aims to design and construct the Brazilian Multipurpose research Reactor (RMB). (author)

  8. Experimental research in neutron physic and thermal-hydraulic at the CDTN Triga reactor

    International Nuclear Information System (INIS)

    Mesquita, Amir Z.; Souza, Rose Mary G.P.; Ferreira, Andrea V.; Pinto, Antonio J.; Costa, Antonio C.L.; Rezende, Hugo C.

    2011-01-01

    The IPR-R1 TRIGA (Training, Research, Isotopes production, General Atomics) at Nuclear Technology Development Center (CDTN) is a pool type reactor cooled by natural circulation of light water and an open surface. TRIGA reactors, developed by General Atomics (GA), are the most widely used research reactor in the world and characterized by inherent safety. The IPR-R1 is the only Brazilian nuclear research reactor available and able to perform experiments in which interaction between neutronic and thermal-hydraulic areas occurs. The IPR-R1 has started up on November 11th, 1960. At that time the maximum thermal power was 30 kW. The present forced cooling system was built in the 70th and the power was upgraded to 100 kW. Recently the core configuration and instrumentation was upgraded again to 250 kW at steady state, and is awaiting the license of CNEN to operate definitely at this new power. This paper describes the experimental research project carried out in the IPR-R1 reactor that has as objective evaluate the behaviour of the reactor operational parameters, and mainly to investigate the influence of temperature on the neutronic variables. The research was supported by Research Support Foundation of the State of Minas Gerais (FAPEMIG) and Brazilian Council for Scientific and Technological Development (CNPq). The research project meets the recommendations of the IAEA, for safety, modernization and development of strategic plan for research reactors utilization. This work is in line with the strategic objectives of Brazil, which aims to design and construct the Brazilian Multipurpose research Reactor (RMB). (author)

  9. Experimental research on thermal characteristics of a hybrid thermocline heat storage system

    International Nuclear Information System (INIS)

    Yin, Huibin; Ding, Jing; Yang, Xiaoxi

    2014-01-01

    Considering the high-temperature thermal utilization of solar energy as the research background in this paper and focussing on the heat storage process, a kind of hybrid thermocline heat storage method in multi-scale structure and relevant experimental systems are designed by using the mixed molten nitrate salt as the heat storage medium and two representative porous materials, i.e. zirconium ball and silicon carbide (SiC) foam, as the heat storage fillers. The fluid flow and heat storage performance of molten salt in multi-scale structure are experimentally investigated. The results show that the theoretical heat storage efficiencies amongst the three experimental heat storage manners are less than 80% because of the existence of thermocline layers. Comparing to the single-phase molten salt heat storage, the two hybrid thermocline heat storage manners with porous fillers lead to a certain decrease in the effective heat storage capacity. The presence of porous fillers can also help to maintain the molten salt fluid as ideal gravity flow or piston flow and partially replace expensive molten salt. Therefore, it requires a combination of heat storage capacity and economical consideration for optimization design when similar spherical particles or foam ceramics are employed as the porous fillers. -- Highlights: • A hybrid thermocline heat storage method in multi-scale structure is developed. • The fluid flow and heat storage performance are experimentally investigated. • Stable thermocline can form in single tank for the experimental cases. • The hybrid thermocline heat storage with porous filler is promising

  10. Appropriateness of the food-pics image database for experimental eating and appetite research with adolescents.

    Science.gov (United States)

    Jensen, Chad D; Duraccio, Kara M; Barnett, Kimberly A; Stevens, Kimberly S

    2016-12-01

    Research examining effects of visual food cues on appetite-related brain processes and eating behavior has proliferated. Recently investigators have developed food image databases for use across experimental studies examining appetite and eating behavior. The food-pics image database represents a standardized, freely available image library originally validated in a large sample primarily comprised of adults. The suitability of the images for use with adolescents has not been investigated. The aim of the present study was to evaluate the appropriateness of the food-pics image library for appetite and eating research with adolescents. Three hundred and seven adolescents (ages 12-17) provided ratings of recognizability, palatability, and desire to eat, for images from the food-pics database. Moreover, participants rated the caloric content (high vs. low) and healthiness (healthy vs. unhealthy) of each image. Adolescents rated approximately 75% of the food images as recognizable. Approximately 65% of recognizable images were correctly categorized as high vs. low calorie and 63% were correctly classified as healthy vs. unhealthy in 80% or more of image ratings. These results suggest that a smaller subset of the food-pics image database is appropriate for use with adolescents. With some modifications to included images, the food-pics image database appears to be appropriate for use in experimental appetite and eating-related research conducted with adolescents. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. The effect of differentiated margin on futures market investors' behavior and structure An experimental research

    Institute of Scientific and Technical Information of China (English)

    Jin-hui Luo; Di-fang Wan; Yang Yang; Guang Yang

    2011-01-01

    Purpose-The purpose of this paper is to empirically analyze the role of differentiated margin system in leading investors' investing behavior and then optimize investor structure in futures markets.Design/methodology/approach-Using economic experimental research method,this paper designs and conducts a futures market experiment according to experimental research's basic norms,thus acquiring needed and credible empirical data.Findings-By analyzing the experimental data,it is found that compared with situations in futures markets that implement uniform margin system,investors' (especially speculators') futures open position and the ratio of their open position and futures turnover are both significantly higher,in futures markets that implement differentiated margin system.On the other hand,differentiated margin system has no effects on hedgers' futures turnover,but significantly reduces speculators' futures turnover.Research limitations/implications-The findings suggest that compared with uniform margin system,differentiated margin system is beneficial to effectively restrict both speculators' and hedgers' speculating behavior and lead hedgers' market participation.Practical implications-In order to resolve the problem of unreasonable investor structure in China's futures market,i.e.lack of hedgers and over-speculating China's futures market's regulators should reform the margin system and adopt differentiated margin system to lead investors' rational behavior and optimize investor structure.Originality/value-This paper empirically analyzes and verifies,for the first time,the roles of differentiated margin system in affecting investors' investing behavior.The futures market experiment designed and used in this study is a pioneering and exploratory experiment.

  12. Current Status of Clinical and Experimental Researches on Cognitive Impairment in Diabetes

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This article reviews the clinical and experimental researches on cognitive impairment related to diabetes in the recent decade. Most clinical studies indicate that the cognitive impairment in patients with type 1 diabetes mellitus is related to recurrent hypoglycemia closely. There is little research about whether or not hyperglycemia is related to cognitive impairment in patients with type 1 diabetes mellitus. Most studies indicate that the cognitive impairment in type 2 diabetes involves multiple factors through multiple mechanisms, including blood glucose, blood lipid, blood pressure, level of insulin, medication, chronic complication, etc. But, there has been no large-scale, multi-center, randomized controlled clinical trial in China recently. And what is more, some problems exist in this field of research, such as the lack of golden criterion of cognitive function measurement, different population of studied objects, and incomprehensive handling of confounding factors. Experimental studies found that hippocampal long-term potentiation (LTP) was impaired,which were manifested by impairment of spatial memory and decreased expression of LTP, but its relation to hyperglycemia, the duration of diabetes, learning and memory has always been differently reported by different researches. Thus, there are a lot of unknown things to be explored and studied in order to clarify its mechanism. TCM has abundant clinical experience in treating cerebral disease with medicine that enforces the kidney and promotes wit. However, there has been no research on treating diabetic cognitive impairment,which requires work to be done actively and TCM to be put into full play, in order to improve the treatment of diabetes and enhance living quality of patients.

  13. Compliance revisited: pharmaceutical drug trials in the era of the contract research organization.

    Science.gov (United States)

    Jonvallen, Petra

    2009-12-01

    Over the past decade, the management of clinical trials of pharmaceuticals has become a veritable industry, as evidenced by the emergence and proliferation of contract research organizations (CROs) that co-ordinate and monitor trials. This article focuses on work performed by one CRO involved in the introduction of new software, modelled on industrial production processes, into clinical trial practices. It investigates how this new management technique relates to the work performed in the clinic to ensure that trial participants comply with the protocol. Using an analytical distinction between 'classical' management work and invisible work, the article contextualizes the meaning of compliance in the clinic and suggests that the work involved in producing compliance should be taken into consideration by those concerned with validity of trials, as clinical trials are put under private industrial management. The article builds on participant observation at a Swedish university hospital and interviews the nurses, dieticians, doctors and a software engineer, all part of a team involved in pharmaceutical drug trials on a potential obesity drug.

  14. Experimental research for γ-ray interference threshold effect of high electromagnetic pulse sensor

    International Nuclear Information System (INIS)

    Meng Cui; Chen Xiangyue; Nie Xin; Xiang Hui; Guo Xiaoqiang; Mao Congguang; Cheng Jianping; Ni Jianping

    2007-01-01

    The high electromagnetic pulse (EMP) sensor using optical-fiber to transmit signal can restrain electromagnetic interference. The Compton electrons scattered by γ-ray irradiated from nuclear explosion or nuclear explosion simulator can generate high EMP, γ-ray can penetrate the shielding box and irradiate the integrated circuit directly. The γ-ray irradiation effect includes interference, latch up and burn out, these will make the measurement result unbelievable. In this paper, the experimental method researching the γ-ray irradiation effect of high electromagnetic pulse sensor on Qiangguang-I accelerator is introduced. The γ-ray dose rate interference threshold is 2 x 10 6 Gy/s. (authors)

  15. The theoretical and experimental researches of Pb-Al composite materials extrusion

    Directory of Open Access Journals (Sweden)

    G. Ryzińska

    2012-07-01

    Full Text Available The work presents the analysis of the character of a simultaneous plastic flow of composite material of a hard core-soft sleeve structure. Experimental research work using model composite material Aluminium-Lead and theoretical analysis allowed to identify the initial cracking conditions, its character and localization, depending on geometrical parameters of the composite materials and the extrusion ratio value. It has been shown that the higher the parameters’ values are, the longer the flawless extruded product is (cracking appears in the further stages of the process.

  16. Experimental Research into Noise Emission of A Gear Micropump with Plastic Rotor

    Science.gov (United States)

    Rodionov, L. V.; Rekadze, P. D.

    2018-01-01

    The previous researches show that it’s possible to replace several parts of gear pump to plastic ones. This substitution leads to cost and noise reduction of the pump. Therefore, the series of acoustic experiments on a test bench were carry-out. Sound pressure levels were recorded with microphone, located in a pipe made of a vacuum rubber. Conducted experiment shows that acoustic characteristics of the micropump depend on the different material of driven rotor. Experimental result indicates that the proposed measures for replacing metal rotor to plastic one reduce micropump noise on the studied modes. The maximum achieved acoustic efficiency on equivalent level is 11 dB.

  17. Experimental research into operating strength and fatigue life of bodywork of buses and trolleybuses

    International Nuclear Information System (INIS)

    Dolhof, V.; Kepka, M.; Rehor, P.; Horak, V.; Sima, J.

    1992-01-01

    Operational strength and fatigue life reliability of trolleybus and bus bodies are usually assessed by computational methods in combination with selected tests. The latter include test runs of vehicles on real routes or on specially designed tracks, tests on complete vehicles under model test conditions and laboratory tests on selected materials, parts and subassemblies. This paper describes a method of experimental investigation of operational strength and reliability developed and applied at the Central Research Institute Skoda for public-transport road vehicles made in Czechoslovakia. (orig.)

  18. Experimental studies on mitigation of LOCA for a high flux research reactor

    International Nuclear Information System (INIS)

    Saxena, A.K.

    2006-01-01

    Experimental studies on the rewetting behaviour of hot vertical annular channels were performed to study the mitigation of consequences of loss of coolant accident (LOCA) for a high flux research reactor. Studies were carried out to study the rewetting behaviour with hot inner tube, for bottom flooding and top flow rewetting conditions. The tube was made of stainless steel. Experiments were conducted for water flow rates in the annulus upto 7 litres per minute (l pm) (11.7 x 10 -5 m 3 s -1 ). The initial surface temperature of the inner tube was varied from 200 to 500 degC. (author)

  19. Experimental Research Into High Barometric Oxygen Prevention of Guinea Pig Hearing Loss,

    Science.gov (United States)

    1992-08-28

    PREVENTION OF GUINEA PIG HEARING LOSS by Yin Jiacai, Sun Fang ren, et al. DTIC MLECTE •<• EP 2 9 1992 Approved for public release, Distribution unlimited...PREVENTION OF GUINEA PIG HEARING LOSS By: Yin Jiacai, Sun Fang ren, et al. English pages: 9 Source: Chung-Hua I Shueh Tsa Chih, Vol. 65, Nr. 11, Nov.eember...Distributionf._DL~~~t .•b • / or __ Dlist szeccat .lef ’ ~1 EXPERIMENTAL RESEARCH INTO HIGH BAROMETRIC OXYGEN PREVENTION OF GUINEA PIG HEARING LOSS BY: Yin

  20. THE EXPERIMENTAL RESEARCH OF THE TECHONOLOGY OF FUTURE ATCO-TRAINERS’ PEDAGOGY COMPETENCE FORMATION

    Directory of Open Access Journals (Sweden)

    Людмила Немлій

    2014-12-01

    Full Text Available The article analyzes the experimental research of pedagogical competence formation of future air traffic control officers-trainers (ATCO-trainers. At the stage of forming experiment a course «Fundamentals of ATCOtrainer’s educational activities» was developed and introduced into the process of professional training of future ATCO-trainers. According to the plan of this course, the organization of educational process was carried out based on the integrative technology. The results of the forming experiment demonstrate the effectiveness of the implemented technologies.