Administration of Oxygen Ultra-Fine Bubbles Improves Nerve Dysfunction in a Rat Sciatic Nerve Crush Injury Model

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Hozo Matsuoka

2018-05-01

Full Text Available Ultra-fine bubbles (<200 nm in diameter have several unique properties and have been tested in various medical fields. The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUBs on a sciatic nerve crush injury (SNC model rats. Rats were intraperitoneally injected with 1.5 mL saline, OUBs diluted in saline, or nitrogen ultra-fine bubbles (NUBs diluted in saline three times per week for 4 weeks in four groups: (1 control, (sham operation + saline; (2 SNC, (crush + saline; (3 SNC+OUB, (crush + OUB-saline; (4 SNC+NUB, (crush + NUB-saline. The effects of the OUBs on dorsal root ganglion (DRG neurons and Schwann cells (SCs were examined by serial dilution of OUB medium in vitro. Sciatic functional index, paw withdrawal thresholds, nerve conduction velocity, and myelinated axons were significantly decreased in the SNC group compared to the control group; these parameters were significantly improved in the SNC+OUB group, although NUB treatment did not affect these parameters. In vitro, OUBs significantly promoted neurite outgrowth in DRG neurons by activating AKT signaling and SC proliferation by activating ERK1/2 and JNK/c-JUN signaling. OUBs may improve nerve dysfunction in SNC rats by promoting neurite outgrowth in DRG neurons and SC proliferation.

Baseline effects of lysophosphatidylcholine and nerve growth factor in a rat model of sciatic nerve regeneration after crush injury

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Ryan L Wood

2018-01-01

Full Text Available Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor (NGF is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine (LPC has been shown to stimulate NGF receptors (NGFR. This study tested the administration of a single intraneural injection of LPC (1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections at day 0 and one (day 7, two (days 5 and 7, or three (days 5, 7, and 9 injections of NGF (160 ng/mL for single injections and 80 ng/mL for multiple injections to determine baseline effects on crushed sciatic nerves in rats. The rats were randomly divided into four groups: control, crush, crush-NGF, and crush-LPC-NGF. The healing of the nerves was measured weekly by monitoring gait; electrophysiological parameters: compound muscle action potential (CMAP amplitudes; and morphological parameters: total fascicle areas, myelinated fiber counts, fiber densities, fiber packing, and mean g-ratio values at weeks 3 and 6. The crush, crush-NGF, and crush-LPC-NGF groups statistically differed from the control group for all six weeks for the electrophysiological parameters but only differed from the control group at week 3 for the morphological parameters. The crush, crush-NGF, and crush-LPC-NGF groups did not differ from each other over the course of the study. Single injections of LPC and NGF one week apart or multiple treatments of NGF at 5, 7 and 9 days post-injury did not alter the healing rate of the sciatic nerves during weeks 1-6 of the study. These findings are important to define the baseline effects of NGF and LPC injections, as part of a larger effort to determine the minimal dose regimen of NGF to regenerate peripheral nerves.

Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury.

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Lin, Tao; Qiu, Shuai; Yan, Liwei; Zhu, Shuang; Zheng, Canbin; Zhu, Qingtang; Liu, Xiaolin

2018-05-01

Improving axonal outgrowth and remyelination is crucial for peripheral nerve regeneration. Miconazole appears to enhance remyelination in the central nervous system. In this study we assess the effect of miconazole on axonal regeneration using a sciatic nerve crush injury model in rats. Fifty Sprague-Dawley rats were divided into control and miconazole groups. Nerve regeneration and myelination were determined using histological and electrophysiological assessment. Evaluation of sensory and motor recovery was performed using the pinprick assay and sciatic functional index. The Cell Counting Kit-8 assay and Western blotting were used to assess the proliferation and neurotrophic expression of RSC 96 Schwann cells. Miconazole promoted axonal regrowth, increased myelinated nerve fibers, improved sensory recovery and walking behavior, enhanced stimulated amplitude and nerve conduction velocity, and elevated proliferation and neurotrophic expression of RSC 96 Schwann cells. Miconazole was beneficial for nerve regeneration and functional recovery after peripheral nerve injury. Muscle Nerve 57: 821-828, 2018. © 2017 Wiley Periodicals, Inc.

Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions.

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Haney, Nora M; Nguyen, Hoang M T; Honda, Matthew; Abdel-Mageed, Asim B; Hellstrom, Wayne J G

2018-04-01

It is common for men to develop erectile dysfunction after radical prostatectomy. The anatomy of the rat allows the cavernous nerve (CN) to be identified, dissected, and injured in a controlled fashion. Therefore, bilateral CN injury (BCNI) in the rat model is routinely used to study post-prostatectomy erectile dysfunction. To compare and contrast the available literature on pharmacologic intervention after BCNI in the rat. A literature search was performed on PubMed for cavernous nerve and injury and erectile dysfunction and rat. Only articles with BCNI and pharmacologic intervention that could be grouped into categories of immune modulation, growth factor therapy, receptor kinase inhibition, phosphodiesterase type 5 inhibition, and anti-inflammatory and antifibrotic interventions were included. To assess outcomes of pharmaceutical intervention on erectile function recovery after BCNI in the rat model. The ratio of maximum intracavernous pressure to mean arterial pressure was the main outcome measure chosen for this analysis. All interventions improved erectile function recovery after BCNI based on the ratio of maximum intracavernous pressure to mean arterial pressure results. Additional end-point analysis examined the corpus cavernosa and/or the major pelvic ganglion and CN. There was extreme heterogeneity within the literature, making accurate comparisons between crush injury and therapeutic interventions difficult. BCNI in the rat is the accepted animal model used to study nerve-sparing post-prostatectomy erectile dysfunction. However, an important limitation is extreme variability. Efforts should be made to decrease this variability and increase the translational utility toward clinical trials in humans. Haney NM, Nguyen HMT, Honda M, et al. Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions. Sex Med Rev 2018;6:234-241. Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier

A numerical approach to model and predict the energy absorption and crush mechanics within a long-fiber composite crush tube

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Pickett, Leon, Jr.

Past research has conclusively shown that long fiber structural composites possess superior specific energy absorption characteristics as compared to steel and aluminum structures. However, destructive physical testing of composites is very costly and time consuming. As a result, numerical solutions are desirable as an alternative to experimental testing. Up until this point, very little numerical work has been successful in predicting the energy absorption of composite crush structures. This research investigates the ability to use commercially available numerical modeling tools to approximate the energy absorption capability of long-fiber composite crush tubes. This study is significant because it provides a preliminary analysis of the suitability of LS-DYNA to numerically characterize the crushing behavior of a dynamic axial impact crushing event. Composite crushing theory suggests that there are several crushing mechanisms occurring during a composite crush event. This research evaluates the capability and suitability of employing, LS-DYNA, to simulate the dynamic crush event of an E-glass/epoxy cylindrical tube. The model employed is the composite "progressive failure model", a much more limited failure model when compared to the experimental failure events which naturally occur. This numerical model employs (1) matrix cracking, (2) compression, and (3) fiber breakage failure modes only. The motivation for the work comes from the need to reduce the significant cost associated with experimental trials. This research chronicles some preliminary efforts to better understand the mechanics essential in pursuit of this goal. The immediate goal is to begin to provide deeper understanding of a composite crush event and ultimately create a viable alternative to destructive testing of composite crush tubes.

Retrograde tracing and toe spreading after experimental autologous nerve transplantation and crush injury of the sciatic nerve: a descriptive methodological study

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van Neerven Sabien GA

2012-04-01

Full Text Available Abstract Evaluation of functional and structural recovery after peripheral nerve injury is crucial to determine the therapeutic effect of a nerve repair strategy. In the present study, we examined the relationship between the structural evaluation of regeneration by means of retrograde tracing and the functional analysis of toe spreading. Two standardized rat sciatic nerve injury models were used to address this relationship. As such, animals received either a 2 cm sciatic nerve defect (neurotmesis followed by autologous nerve transplantation (ANT animals or a crush injury with spontaneous recovery (axonotmesis; CI animals. Functional recovery of toe spreading was observed over an observation period of 84 days. In contrast to CI animals, ANT animals did not reach pre-surgical levels of toe spreading. After the observation period, the lipophilic dye DiI was applied to label sensory and motor neurons in dorsal root ganglia (DRG; sensory neurons and spinal cord (motor neurons, respectively. No statistical difference in motor or sensory neuron counts could be detected between ANT and CI animals. In the present study we could indicate that there was no direct relationship between functional recovery (toe spreading measured by SSI and the number of labelled (motor and sensory neurons evaluated by retrograde tracing. The present findings demonstrate that a multimodal approach with a variety of independent evaluation tools is essential to understand and estimate the therapeutic benefit of a nerve repair strategy.

Early myelin breakdown following sural nerve crush: a freeze-fracture study

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Martinez A.M.B.

2000-01-01

Full Text Available In this study we describe the early changes of the myelin sheath following surgical nerve crush. We used the freeze-fracture technique to better evaluate myelin alterations during an early stage of Wallerian degeneration. Rat sural nerves were experimentally crushed and animals were sacrificed by transcardiac perfusion 30 h after surgery. Segments of the nerves were processed for routine transmission electron microscopy and freeze-fracture techniques. Our results show that 30 h after the lesion there was asynchrony in the pattern of Wallerian degeneration, with different nerve fibers exhibiting variable degrees of axon disruption. This was observed by both techniques. Careful examination of several replicas revealed early changes in myelin membranes represented by vacuolization and splitting of consecutive lamellae, rearrangement of intramembranous particles and disappearance of paranodal transverse bands associated or not with retraction of paranodal myelin terminal loops from the axolemma. These alterations are compatible with a direct injury to the myelin sheath following nerve crush. The results are discussed in terms of a similar mechanism underlying both axon and myelin breakdown.

Experimental Characterization of the Energy Absorption of Functionally Graded Foam Filled Tubes Under Axial Crushing Loads

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Ebrahimi, Saeed; Vahdatazad, Nader; Liaghat, Gholamhossein

2018-03-01

This paper deals with the energy absorption characterization of functionally graded foam (FGF) filled tubes under axial crushing loads by experimental method. The FGF tubes are filled axially by gradient layers of polyurethane foams with different densities. The mechanical properties of the polyurethane foams are firstly obtained from axial compressive tests. Then, the quasi-static compressive tests are carried out for empty tubes, uniform foam filled tubes and FGF filled tubes. Before to present the experimental test results, a nonlinear FEM simulation of the FGF filled tube is carried out in ABAQUS software to gain more insight into the crush deformation patterns, as well as the energy absorption capability of the FGF filled tube. A good agreement between the experimental and simulation results is observed. Finally, the results of experimental test show that an FGF filled tube has excellent energy absorption capacity compared to the ordinary uniform foam-filled tube with the same weight.

Acute crush injuries of skeletal muscle of mice with ice-compression therapy: a dynamic study with diffusion tensor imaging

International Nuclear Information System (INIS)

Wang Fengzhe; Pan Shinong; An Qi; Shu Hong; Li Qi; Sun He; Zhang Guangxin; Guo Qiyong

2010-01-01

Objective: To evaluate the value of ice-compression therapy in mice skeletal muscle after acute crush injuries and correlate treatment effect with different compression time by MR DTI. Methods: Forty Weistar mice were randomly divided into 4 groups by random number table method: control group (A), 5 min compression time group (B), 15 min compression time group (C) and 30 min compression time group (D). Diffusion tensor imaging examinations were performed before, immediately after, 24, 48 and 72 hours after injuries. ADC and FA values were calculated by fiber tracking tool. The morphological changes were confirmed by histopathology, and immunohistochemical methods were used for the assessment of Desmin expression with mean of A value. Statistical analysis by LSD-t test and Spearman rank correlation. Results: (1) For every group before injuries, ADC values were (1.38±0.04) × 10 -3 , (1.38±0.08) × 10 -3 , (1.34±0.05) × 10 -3 , (1.36±0.09) × 10 -3 mm 2 /s respectively, FA value were 0.46±0.05, 0.45±0.03, 0.45±0.05, 0.48±0.04 respectively. ADC values increased significantly and FA values reduced in each group immediately after injuries compared with pre-injury values. ADC values were (1.84± 0.10) × 10 -3 (1.79±0.09) × 10 -3 , (1.55±0.07) × 10 -3 , (1.57±0.04) × 10 -3 mm 2 /s respectively, FA value were 0.21±0.04, 0.26±0.03, 0.31±0.02, 0.30±0.04 respectively. ADC values were still higher and FA values lower than pre-injury values at 24 hours after injury in A, B groups. ADC values were (1.54±0.13) × 10 -3 , (1.57±0.13) × 10 -3 mm 2 /s, FA value were 0.25±0.03, 0.26±0.02. (2) DTT showed fibers distorted and the number of fiber bundles reduced, some separation and displacement in each group immediately after injury. C, D groups improved more than A, B groups over time. (3) The disorder arrangement of skeletal muscle cells with edema and filaments separation were found in HE staining after injury, but the degree mitigated in C, D groups. Desmin

Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury.

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Ding, Zhuofeng; Cao, Jiawei; Shen, Yu; Zou, Yu; Yang, Xin; Zhou, Wen; Guo, Qulian; Huang, Changsheng

2018-01-01

Peripheral nerve injuries are generally associated with incomplete restoration of motor function. The slow rate of nerve regeneration after injury may account for this. Although many benefits of resveratrol have been shown in the nervous system, it is not clear whether resveratrol could promote fast nerve regeneration and motor repair after peripheral nerve injury. This study showed that the motor deficits caused by sciatic nerve crush injury were alleviated by daily systematic resveratrol treatment within 10 days. Resveratrol increased the number of axons in the distal part of the injured nerve, indicating enhanced nerve regeneration. In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. The above results indicated that daily systematic resveratrol treatment promoted nerve regeneration and led to rapid motor repair. Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair.

Correlation between muscle electrical impedance data and standard neurophysiologic parameters after experimental neurogenic injury

International Nuclear Information System (INIS)

Ahad, M; Rutkove, S B

2010-01-01

Previous work has shown that electrical impedance measurements of muscle can assist in quantifying the degree of muscle atrophy resulting from neuronal injury, with impedance values correlating strongly with standard clinical parameters. However, the relationship between such data and neurophysiologic measurements is unexplored. In this study, 24 Wistar rats underwent sciatic crush, with measurement of the 2–1000 kHz impedance spectrum, standard electrophysiological measures, including nerve conduction studies, needle electromyography, and motor unit number estimation (MUNE) before and after sciatic crush, with animals assessed weekly for 4 weeks post-injury. All electrical impedance values, including a group of 'collapsed' variables, in which the spectral characteristics were reduced to single values, showed reductions as high as 47.2% after sciatic crush, paralleling and correlating with changes in compound motor action potential amplitude, conduction velocity and most closely to MUNE, but not to the presence of fibrillation potentials observed on needle electromyography. These results support the concept that localized impedance measurements can serve as surrogate makers of nerve injury; these measurements may be especially useful in assessing nerve injury impacting proximal or axial muscles where standard quantitative neurophysiologic methods such as nerve conduction or MUNE cannot be readily performed

Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model

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Ibrahim Erkutlu

2015-01-01

Full Text Available Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug injection injury. This study aimed to assess the time-dependent efficacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by penicillin G potassium administration (30 minutes, 8 or 24 hours. The compound muscle action potentials were recorded pre-injury, early post-injury (within 1 hour and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant improvement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury (P < 0.05; at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin G potassium injection.

EXPERIMENTAL RESEARCH OF PROCESSING OF DUMP SAND-CLAY MIXES BY THE CENTRIFUGAL AND SHOCK CRUSHING

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V. V. Vorobev

2015-01-01

Full Text Available Results of experimental research of processing of centrifugal and shock crushing of dump sandy-clay mixes are given. Use of products of processing of received mixes in foundry production and in production of asphalt concrete mixes allows to exclude transportation of the mix to dumping.

Crushing of ship bows in head-on collision

DEFF Research Database (Denmark)

Ocakli, H.; Zhang, S.; Pedersen, Preben Terndrup

2004-01-01

Semi-analytical methods for analysis of plate crushing and ship bow damage in head-on collisions are developed in this paper. Existing experimental and theoretical studies for crushing analysis of plated structures are summarized and compared. Simple formulae for determining the crushing force....... The approach developed can be used easily to determine the crushing resistance and damage extent of the ship bow when ship length and collision speed are known. The method can be used in probabilistic analysis of damage extents in ship collisions where a large number of calculations are generally required....

The effect of weight-bearing exercise and non-weight-bearing exercise on gait in rats with sciatic nerve crush injury.

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Kim, Ki-Hyun; Hwangbo, Gak; Kim, Seong-Gil

2015-04-01

[Purpose] The purpose of this study was to access the effect of weight bearing exercise (treadmill exercise) and non-weight-bearing exercise (swimming exercise) on gait in the recovery process after a sciatic nerve crush injury. [Subjects and Methods] Rats were randomly divided into a swimming group (n=3) with non-weight-bearing exercise after a sciatic nerve crush and a treadmill group (n=3) with weight bearing exercise after a sciatic nerve crush. Dartfish is a program that can analyze and interpret motion through video images. The knee lateral epicondyle, lateral malleolus, and metatarsophalangeal joint of the fifth toe were marked by black dots before recording. [Results] There were significant differences in TOK (knee angle toe off) and ICK (knee angle at initial contact) in the swimming group and in TOK, ICA (ankle angle at initial contact), and ICK in the treadmill group. In comparison between groups, there were significant differences in TOA (ankle angle in toe off) and ICA at the 7th day. [Conclusion] There was no difference between weight bearing and non-weight-bearing exercise in sciatic nerve damage, and both exercises accelerated the recovery process in this study.

Digital radiography of crush thoracic trauma in the Sichuan earthquake

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Dong, Zhi-Hui; Shao, Heng; Chen, Tian-Wu; Chu, Zhi-Gang; Deng, Wen; Tang, Si-Shi; Chen, Jing; Yang, Zhi-Gang

2011-01-01

AIM: To investigate the features of crush thoracic trauma in Sichuan earthquake victims using chest digital radiography (CDR). METHODS: We retrospectively reviewed 772 CDR of 417 females and 355 males who had suffered crush thoracic trauma in the Sichuan earthquake. Patient age ranged from 0.5 to 103 years. CDR was performed between May 12, 2008 and June 7, 2008. We looked for injury to the thoracic cage, pulmonary parenchyma and the pleura. RESULTS: Antero-posterior (AP) and lateral CDR were obtained in 349 patients, the remaining 423 patients underwent only AP CDR. Thoracic cage fractures, pulmonary contusion and pleural injuries were noted in 331 (42.9%; 95% CI: 39.4%-46.4%), 67 and 135 patients, respectively. Of the 256 patients with rib fractures, the mean number of fractured ribs per patient was 3. Rib fractures were mostly distributed from the 3rd through to the 8th ribs and the vast majority involved posterior and lateral locations along the rib. Rib fractures had a significant positive association with non-rib thoracic fractures, pulmonary contusion and pleural injuries (P < 0.001). The number of rib fractures and pulmonary contusions were significant factors associated with patient death. CONCLUSION: Earthquake-related crush thoracic trauma has the potential for multiple fractures. The high number of fractured ribs and pulmonary contusions were significant factors which needed appropriate medical treatment. PMID:22132298

The Changes in Rats with Sciatic Nerve Crush Injury Supplemented with Evening Primrose Oil: Behavioural, Morphologic, and Morphometric Analysis

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Danial Ramli

2017-01-01

Full Text Available Nerve crush injuries are commonly used models for axonotmesis to examine peripheral nerve regeneration. As evening primrose oil (EPO is rich in omega-6 essential fatty acid component and gamma-linolenic acid, studies have shown the potential role of EPO in myelination. Seventy-two healthy adult Sprague-Dawley rats were classified into three groups: normal group, control group, and experimental group. The result indicates that there was significant difference in toe-spreading reflex between the normal and the control groups (1.9±0.031, p<0.05 and the normal and the EPO groups (0.4±0.031, p<0.05 and significant difference between EPO and the control groups (1.5±0.031, p<0.05. Regeneration of axons and myelin in nerve fibre in the EPO-treated group developed better and faster than in the control group. In the control group, the shape of the axon was irregular with a thinner myelin sheath. In the experimental group, the shape of the axons, the thickness of the myelin sheath, and the diameter of the axons were almost the same as in the normal group. In conclusion, EPO supplementation may be beneficial as a therapeutic option for disturbances of nerve interaction.

Dynamic Response and Residual Helmet Liner Crush Using Cadaver Heads and Standard Headforms.

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Bonin, S J; Luck, J F; Bass, C R; Gardiner, J C; Onar-Thomas, A; Asfour, S S; Siegmund, G P

2017-03-01

Biomechanical headforms are used for helmet certification testing and reconstructing helmeted head impacts; however, their biofidelity and direct applicability to human head and helmet responses remain unclear. Dynamic responses of cadaver heads and three headforms and residual foam liner deformations were compared during motorcycle helmet impacts. Instrumented, helmeted heads/headforms were dropped onto the forehead region against an instrumented flat anvil at 75, 150, and 195 J. Helmets were CT scanned to quantify maximum liner crush depth and crush volume. General linear models were used to quantify the effect of head type and impact energy on linear acceleration, head injury criterion (HIC), force, maximum liner crush depth, and liner crush volume and regression models were used to quantify the relationship between acceleration and both maximum crush depth and crush volume. The cadaver heads generated larger peak accelerations than all three headforms, larger HICs than the International Organization for Standardization (ISO), larger forces than the Hybrid III and ISO, larger maximum crush depth than the ISO, and larger crush volumes than the DOT. These significant differences between the cadaver heads and headforms need to be accounted for when attempting to estimate an impact exposure using a helmet's residual crush depth or volume.

DK crush (double-kissing and double-crush) technique for treatment of true coronary bifurcation lesions: illustration and comparison with classic crush.

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Chen, Shaoliang; Zhang, Junjie; Ye, Fei; Zhu, Zhongsheng; Lin, Song; Shan, Shoujie; Kwan, Tak W

2007-04-01

Classic crush has a lower success rate compared to final kissing balloon inflation (FKBI). We previously reported the double-kissing (DK) crush technique that involves double-kissing along with double-crushing for the treatment of true bifurcation coronary lesions in 2005. This is a consecutive, nonrandomized, open-label study. Eighty-eight consecutive patients with single, true coronary bifurcation lesions according to Lefevre Classification2 and side branch diameter >2.0 mm were enrolled. The first 44 patients (from October 2004 to January 2005) were assigned to the classic crush treatment arm and the next 44 patients (from February 2005 to June 2005) were assigned to the DK crush technique arm, respectively. Data within 30 days were analyzed. Patients in the DK crush group, compared to those in classic crush group, were characterized by longer lesion length in the side branch (13.5 +/- 3.4 mm vs 7.8 +/- 3.1 mm; p DK crush group, as well as longer lesion length in the main vessel (24.3 +/- 8.6 mm vs 21.1 +/- 7.3 mm), though without significant differences (p >0.05). Subacute stent thrombosis was detected in 2 patients with failure of FKBI in the classic crush group (4.3%). In addition, patients in the classic crush group were characterized by a smaller minimum lumen diameter (MLD) at the side branch ostium (2.74 +/- 0.12 mm vs 3.01 +/- 0.13 mm; p DK crush has the potential to improve the clinical outcome in patients with coronary bifurcation lesions. Further randomized, prospective, multicenter studies are required to confirm these differences between the classic crush and DK crush techniques.

Automation for Crushing and Screening Equipment to Produce Graded Paving Crushed Stone

Science.gov (United States)

Tikhonov, Anatoly; Velichkin, Vladimir

2017-10-01

This paper offers analysis of factors related to production and storage of graded crushed stone, which adversely impact the service life and wear resistance of asphalt-concrete motor road pavements. The paper describes external and technology-related parameters that may cause changes of the preset ratio in graded crushed stone. Control factors are described that ensure the formulated fraction ratio in crushed stone by controlling the operation mode of the crushing and screening equipment. The paper also contains an ACS flow chart for crushing and screening equipment engaged in continuous closed-cycle two-stage technology. Performance of the ACS to maintain the preset fractionated crushed stone ratio has been confirmed with a mathematical model.

Ultrasound-guided plasma rich in growth factors injections and scaffolds hasten motor nerve functional recovery in an ovine model of nerve crush injury.

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Sánchez, Mikel; Anitua, E; Delgado, D; Prado, R; Sánchez, P; Fiz, N; Guadilla, J; Azofra, J; Pompei, O; Orive, G; Ortega, M; Yoshioka, T; Padilla, S

2017-05-01

In the present study we evaluated the motor recovery process of peripheral nerve injury (PNI), based on electrophysiological and histomorphometric criteria, after treatment with plasma rich in growth factors (PRGF) injections and scaffolds in an ovine model. Three groups of sheep underwent a nerve crush lesion: the first group (n = 3) was left to recover spontaneously (SR); the second group was administered saline injections (SI; n = 5) and a third group (n = 6) received PRGF injections and scaffolds immediately after the crush injury. At post-intervention week 8, 70% of sheep in the PRGF group were CMAP-positive, with no electrophysiological response in the rest of the groups. Histomorphometric analysis 12 weeks after the surgical intervention revealed that the average axonal density of the SR (1184 ± 864 axons/µm 2 ) and SI (3109 ± 2450 axons/µm 2 ) groups was significantly inferior to the control (8427 ± 2433 axons/µm 2 ) and also inferior to the PRGF group (5276 ± 4148 axons/µm 2 ), showing no significant differences between the control and PRGF groups. The axonal size of the SR and SI groups was significantly smaller compared with the control group (18 ± 4 µm 2 ), whereas the axonal size of the PRGF group (6 ± 5 µm 2 ) did not show statistical differences from the control. Morphometry of the target muscles indicated that the PRGF group had the lowest percentage volume reduction 12 weeks after the crush injury. The PRGF group had larger muscle fibre areas than the SI and SR groups, although the differences did not reach statistical significance. Overall, these data suggest that the PRGF injections and scaffolds hastened functional axon recovery and dampened atrophy of the target muscles in an ovine model. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Escalated regeneration in sciatic nerve crush injury by the combined therapy of human amniotic fluid mesenchymal stem cells and fermented soybean extracts, Natto.

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Pan, Hung-Chuan; Yang, Dar-Yu; Ho, Shu-Peng; Sheu, Meei-Ling; Chen, Chung-Jung; Hwang, Shiaw-Min; Chang, Ming-Hong; Cheng, Fu-Chou

2009-08-23

Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented soybean extracts (Natto) was also beneficial to nerve regeneration. In this study, the effect of Natto on transplanted human amniotic fluid mesenchymal stem cells (AFS) was evaluated. Peripheral nerve injury was induced in SD rats by crushing a sciatic nerve using a vessel clamp. Animals were categorized into four groups: Group I: no treatment; Group II: fed with Natto (16 mg/day for 7 consecutive days); Group III: AFS embedded in fibrin glue; Group IV: Combination of group II and III therapy. Transplanted AFS and Schwann cell apoptosis, inflammatory cell deposits and associated cytokines, motor function, and nerve regeneration were evaluated 7 or 28 days after injury. The deterioration of neurological function was attenuated by AFS, Natto, or the combined therapy. The combined therapy caused the most significantly beneficial effects. Administration of Natto suppressed the inflammatory responses and correlated with decreased AFS and Schwann cell apoptosis. The decreased AFS apoptosis was in line with neurological improvement such as expression of early regeneration marker of neurofilament and late markers of S-100 and decreased vacuole formation. Administration of either AFS, or Natto, or combined therapy augmented the nerve regeneration. In conclusion, administration of Natto may rescue the AFS and Schwann cells from apoptosis by suppressing the macrophage deposits, associated inflammatory cytokines, and fibrin deposits.

Escalated regeneration in sciatic nerve crush injury by the combined therapy of human amniotic fluid mesenchymal stem cells and fermented soybean extracts, Natto

Directory of Open Access Journals (Sweden)

Pan Hung-Chuan

2009-08-01

Full Text Available Abstract Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented soybean extracts (Natto was also beneficial to nerve regeneration. In this study, the effect of Natto on transplanted human amniotic fluid mesenchymal stem cells (AFS was evaluated. Peripheral nerve injury was induced in SD rats by crushing a sciatic nerve using a vessel clamp. Animals were categorized into four groups: Group I: no treatment; Group II: fed with Natto (16 mg/day for 7 consecutive days; Group III: AFS embedded in fibrin glue; Group IV: Combination of group II and III therapy. Transplanted AFS and Schwann cell apoptosis, inflammatory cell deposits and associated cytokines, motor function, and nerve regeneration were evaluated 7 or 28 days after injury. The deterioration of neurological function was attenuated by AFS, Natto, or the combined therapy. The combined therapy caused the most significantly beneficial effects. Administration of Natto suppressed the inflammatory responses and correlated with decreased AFS and Schwann cell apoptosis. The decreased AFS apoptosis was in line with neurological improvement such as expression of early regeneration marker of neurofilament and late markers of S-100 and decreased vacuole formation. Administration of either AFS, or Natto, or combined therapy augmented the nerve regeneration. In conclusion, administration of Natto may rescue the AFS and Schwann cells from apoptosis by suppressing the macrophage deposits, associated inflammatory cytokines, and fibrin deposits.

Bipolar electrocautery: A rodent model of Sunderland third-degree nerve injury.

Science.gov (United States)

Moradzadeh, Arash; Brenner, Michael J; Whitlock, Elizabeth L; Tong, Alice Y; Luciano, Janina P; Hunter, Daniel A; Myckatyn, Terence M; Mackinnon, Susan E

2010-01-01

To determine the Sunderland classification of a bipolar electrocautery injury. Twenty-two rats received crush (a reproducible Sunderland second-degree injury) or bipolar electrocautery injury and were evaluated for functional, histomorphometric, and immunohistochemical recovery at 21 or 42 days. Animal experiments were performed between July 3 and December 12, 2007. Axonal regeneration and end plate reinnervation were evaluated in double transgenic cyan fluorescent protein-conjugated Thy1 and green fluorescent protein-conjugated S100 mice. Compared with crush injury, bipolar electrocautery injury caused greater disruption of myelin and neurofilament architecture at the injury site and decreased nerve fiber counts and percentage of neural tissue distal to the injury (P =.007). Complete functional recovery was seen after crush but not bipolar electrocautery injury. Serial live imaging demonstrated axonal regeneration at week 1 after crush and at week 3 after bipolar electrocautery injury. Qualitative assessment of motor end plate reinnervation at 42 days demonstrated complete neuromuscular end plate reinnervation in the crush group and only limited reinnervation in the bipolar electrocautery group. Bipolar electrocautery injury in a rodent model resulted in a Sunderland third-degree injury, characterized by gradual, incomplete recovery without intervention.

Crush Grinding

International Nuclear Information System (INIS)

Nguyen, T.Q.

2005-01-01

Crush Grinding is a special process used at the Kansas City Plant to finish stem sections of reservoir products. In this process, a precise profile of the desired product is formed on a tungsten carbide roll. This roll slowly transfers a mirror image of the profile onto the grinding surface of a wheel. The transfer rate of the profile is between 0.001 and 0.010 inches per minute. Crush grinding is desirable since it provides consistent surface finishes and thin walls at a high production rate. In addition, it generates very sharp fillet radii. However, crush grinding is a complex process since many variables affect the final product. Therefore, the process requires more attention and knowledge beyond basic metal removal practices. While the Kansas City Plant began using these machines in 1995, a formal study regarding crush grinding has not been conducted there. In addition, very little literature is available in the grinding industry regarding this process. As a result, new engineers at the Kansas City Plant must learn the process through trial and error. The purpose of this document is to address this literature deficit while specifically promoting a better understanding of the stem crush grinding process at the Kansas City Plant.

Thermal conductivity of crushed salt

International Nuclear Information System (INIS)

Kuehn, K.

Heat transfer through an annular space filled with crushed salt depends primarily on the thermal conductivity, lambda, of the material. This report gives a formula with which lambda can be computed. The formula includes two quantities that can be influenced through screening of the salt smalls: the porosity, psi, and the fraction, alpha, of the more highly resistive heat-flow paths. The report computes and presents graphically the thermal conductivities for various values of psi and alpha. Heat-transfer properties are computed and compared for an annular space filled with crushed salt and for an air gap. The comparison shows that the properties of the annular space are larger only up to a certain temperature, because the properties of the air gap increase exponentially while those f the annular space increase only in an approximately linear way. Experimental results from Project Salt Vault in the U.S. are in good agreement with the calculations performed. Trials in Temperature Experimental Field 2 at the Asse II salt mine will provide an additional check on the calculations. 3 figures, 3 tables

Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr Pers. (Aphyllophoromycetideae

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Kah-Hui Wong

2011-01-01

Full Text Available Nerve crush injury is a well-established axonotmetic model in experimental regeneration studies to investigate the impact of various pharmacological treatments. Hericium erinaceus is a temperate mushroom but is now being cultivated in tropical Malaysia. In this study, we investigated the activity of aqueous extract of H. erinaceus fresh fruiting bodies in promoting functional recovery following an axonotmetic peroneal nerve injury in adult female Sprague-Dawley rats by daily oral administration. The aim was to investigate the possible use of this mushroom in the treatment of injured nerve. Functional recovery was assessed in behavioral experiment by walking track analysis. Peroneal functional index (PFI was determined before surgery and after surgery as rats showed signs of recovery. Histological examinations were performed on peroneal nerve by immunofluorescence staining and neuromuscular junction by combined silver-cholinesterase stain. Analysis of PFI indicated that return of hind limb function occurred earlier in rats of aqueous extract or mecobalamin (positive control group compared to negative control group. Regeneration of axons and reinnervation of motor endplates in extensor digitorum longus muscle in rats of aqueous extract or mecobalamin group developed better than in negative control group. These data suggest that daily oral administration of aqueous extract of H. erinaceus fresh fruiting bodies could promote the regeneration of injured rat peroneal nerve in the early stage of recovery.

Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)

Science.gov (United States)

Wong, Kah-Hui; Naidu, Murali; David, Pamela; Abdulla, Mahmood Ameen; Abdullah, Noorlidah; Kuppusamy, Umah Rani; Sabaratnam, Vikineswary

2011-01-01

Nerve crush injury is a well-established axonotmetic model in experimental regeneration studies to investigate the impact of various pharmacological treatments. Hericium erinaceus is a temperate mushroom but is now being cultivated in tropical Malaysia. In this study, we investigated the activity of aqueous extract of H. erinaceus fresh fruiting bodies in promoting functional recovery following an axonotmetic peroneal nerve injury in adult female Sprague-Dawley rats by daily oral administration. The aim was to investigate the possible use of this mushroom in the treatment of injured nerve. Functional recovery was assessed in behavioral experiment by walking track analysis. Peroneal functional index (PFI) was determined before surgery and after surgery as rats showed signs of recovery. Histological examinations were performed on peroneal nerve by immunofluorescence staining and neuromuscular junction by combined silver-cholinesterase stain. Analysis of PFI indicated that return of hind limb function occurred earlier in rats of aqueous extract or mecobalamin (positive control) group compared to negative control group. Regeneration of axons and reinnervation of motor endplates in extensor digitorum longus muscle in rats of aqueous extract or mecobalamin group developed better than in negative control group. These data suggest that daily oral administration of aqueous extract of H. erinaceus fresh fruiting bodies could promote the regeneration of injured rat peroneal nerve in the early stage of recovery. PMID:21941586

[Experimental study on regeneration of sciatic nerve injury with physical therapy].

Science.gov (United States)

Zhao, Juan; Yu, Hong; Xu, Yiming; Bai, Yuehong

2011-01-01

Peripheral nerve injury is a common clinical disease, to study the effects of the physical therapy on the regeneration of the injured sciatic nerve, and provide a reference for clinical treatment. Sixty-four female adult Wistar rats (weighing 252-365 g) were chosen and randomly divided into 4 groups (n = 16): group A, group B, group C, and group D. The experimental model of sciatic nerve defect was established by crushing the right sciatic nerve in groups B, C, and D; group A served as the control group without crushing. At 2 days after injury, no treatment was given in group B, electrical stimulation in group C, and combined physical therapies (decimeter and infrared ray) in group D. At 0, 7, 14, and 30 days after treatment, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MNCV) were measured, and morphological and transmission electron microscopy (TEM) examinations were done; at 30 days after treatment, the morphological evaluation analysis of axons was performed. At 0 and 7 days after treatment, the SFI values of groups B, C, and D were significantly higher than that of group A (P 0.05) at 30 days; whereas the SFI values of groups B and C decreased, showing significant difference when compared with the value of group A (P 0.05). At 0 and 7 days, only collagen and lipid were observed by TEM; at 14 and 30 days, many Schwann cells and perineurial cells in regeneration axon were observed in groups B, C, and D, especially in group D. Automated image analysis of axons showed that there was no significant difference in the number of myelinated nerve fibers, axon diameter, and myelin sheath thickness between group D and group A (P > 0.05), and the number of myelinated nerve fibers and axon diameter of group D were significantly higher than those of groups B and C (P < 0.05). Physical therapy can improve the regeneration of the injured sciatic nerve of rats.

The effect of motorcycle helmet fit on estimating head impact kinematics from residual liner crush.

Science.gov (United States)

Bonin, Stephanie J; Gardiner, John C; Onar-Thomas, Arzu; Asfour, Shihab S; Siegmund, Gunter P

2017-09-01

Proper helmet fit is important for optimizing head protection during an impact, yet many motorcyclists wear helmets that do not properly fit their heads. The goals of this study are i) to quantify how a mismatch in headform size and motorcycle helmet size affects headform peak acceleration and head injury criteria (HIC), and ii) to determine if peak acceleration, HIC, and impact speed can be estimated from the foam liner's maximum residual crush depth or residual crush volume. Shorty-style helmets (4 sizes of a single model) were tested on instrumented headforms (4 sizes) during linear impacts between 2.0 and 10.5m/s to the forehead region. Helmets were CT scanned to quantify residual crush depth and volume. Separate linear regression models were used to quantify how the response variables (peak acceleration (g), HIC, and impact speed (m/s)) were related to the predictor variables (maximum crush depth (mm), crush volume (cm 3 ), and the difference in circumference between the helmet and headform (cm)). Overall, we found that increasingly oversized helmets reduced peak headform acceleration and HIC for a given impact speed for maximum residual crush depths less than 7.9mm and residual crush volume less than 40cm 3 . Below these levels of residual crush, we found that peak headform acceleration, HIC, and impact speed can be estimated from a helmet's residual crush. Above these crush thresholds, large variations in headform kinematics are present, possibly related to densification of the foam liner during the impact. Copyright © 2017 Elsevier Ltd. All rights reserved.

A benchmark study of procedures for analysis of axial crushing of bulbous bows

DEFF Research Database (Denmark)

Yamada, Yasuhira; Pedersen, Preben Terndrup

2008-01-01

Simplified methods to estimate mean axial crushing forces of plated structures are reviewed and applied to a series of experimental results for axial crushing of large-scale bulbous bow models. Methods based on intersection unit elements such as L-, T- and X-type elements as well as methods based...

Fractal and Morphological Characteristics of Single Marble Particle Crushing in Uniaxial Compression Tests

Directory of Open Access Journals (Sweden)

Yidong Wang

2015-01-01

Full Text Available Crushing of rock particles is a phenomenon commonly encountered in geotechnical engineering practice. It is however difficult to study the crushing of rock particles using classical theory because the physical structure of the particles is complex and irregular. This paper aims at evaluating fractal and morphological characteristics of single rock particle. A large number of particle crushing tests are conducted on single rock particle. The force-displacement curves and the particle size distributions (PSD of crushed particles are analysed based on particle crushing tests. Particle shape plays an important role in both the micro- and macroscale responses of a granular assembly. The PSD of an assortment of rocks are analysed by fractal methods, and the fractal dimension is obtained. A theoretical formula for particle crushing strength is derived, utilising the fractal model, and a simple method is proposed for predicting the probability of particle survival based on the Weibull statistics. Based on a few physical assumptions, simple equations are derived for determining particle crushing energy. The results of applying these equations are tested against the actual experimental data and prove to be very consistent. Fractal theory is therefore applicable for analysis of particle crushing.

Effect of pigment epithelium derived factor on NO and the expression of caspase-3 in retinal tissues of model rats with optic nerve crush injury

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Xiao-Xiao Yan

2017-06-01

Full Text Available AIM: To analyze the effect of pigment epithelium derived factor(PEDFon nitrogen monoxide(NOand expression of cysteine-containing, aspartate-specific proteases-3(caspase-3in retinal tissues of model rats with optic nerve crush injury. METHODS: A total of 60 SD rats were randomly divided into the blank control group, model group and PEDF group, with 20 rats in each group. Except the blank control group, the optic nerve crush injury rat models were established in the other groups, and left eyeballs were taken as samples. After successfully modeling, the model group were treated with intravitreal injection of 5μL of balanced salt solution while PEDF group were treated with intravitreal injection of 5μL of PEDF(0.2μg/μL. Two weeks later, the retinal tissues were collected, and changes of shape were observed under microscope after HE staining. The changes of NO level were measured by colorimetry assay, the expression of caspase-3 mRNA and caspase-3 protein was detected by reverse transcription-polymerase chain reaction(RT-PCRand Western-blot. RESULTS: HE staining showed that retinal tissues of the blank control group arranged neatly and clearly. Retinal ganglion cells(RGCsarranged in a monolayer, and cells were oval, uniform in size and distribution, the cell nuclei were clear, closely arranged, with clear boundaries. The retinal tissues of the model group were sparse in shape, RGCs showed vacuolar changes, the overall number of cells was reduced, and cell nuclei of residual RGCs showed pyknosis and uneven staining. RGCs in PEDF group were with slightly edema and arranged closely, and the degree of injury was significantly milder than that in the model group. Levels of Caspase-3 mRNA and protein and NO levels in the three groups showed the model group > PEDF group > blank control group(all P CONCLUSION: The application of PEDF can down regulate the expression of Caspase-3 and NO in rates with optic nerve injury and reduce RGCs injury.

21 CFR 137.195 - Crushed wheat.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Crushed wheat. 137.195 Section 137.195 Food and... Related Products § 137.195 Crushed wheat. Crushed wheat, coarse ground wheat, is the food prepared by so crushing cleaned wheat other than durum wheat and red durum wheat that, when tested by the method...

The Effects of Phrenic Nerve Degeneration by Axotomy and Crush on the Electrical Activities of Diaphragm Muscles of Rats.

Science.gov (United States)

Alkiş, Mehmet Eşref; Kavak, Servet; Sayır, Fuat; Him, Aydin

2016-03-01

The aim of this study was to investigate the effect of axotomy and crush-related degeneration on the electrical activities of diaphragm muscle strips of experimental rats. In the present study, twenty-one male Wistar-albino rats were used and divided into three groups. The animals in the first group were not crushed or axotomized and served as controls. Phrenic nerves of the rats in the second and third groups were crushed or axotomized in the diaphragm muscle. Resting membrane potential (RMP) was decreased significantly in both crush and axotomy of diaphragm muscle strips of experimental rats (p phrenic nerves may produce electrical activities in the diaphragm muscle of the rat by depolarization time and half-repolarization time prolonged in crush and axotomy rats.

Deficient functional recovery after facial nerve crush in rats is associated with restricted rearrangements of synaptic terminals in the facial nucleus.

Science.gov (United States)

Hundeshagen, G; Szameit, K; Thieme, H; Finkensieper, M; Angelov, D N; Guntinas-Lichius, O; Irintchev, A

2013-09-17

Crush injuries of peripheral nerves typically lead to axonotmesis, axonal damage without disruption of connective tissue sheaths. Generally, human patients and experimental animals recover well after axonotmesis and the favorable outcome has been attributed to precise axonal reinnervation of the original peripheral targets. Here we assessed functionally and morphologically the long-term consequences of facial nerve axonotmesis in rats. Expectedly, we found that 5 months after crush or cryogenic nerve lesion, the numbers of motoneurons with regenerated axons and their projection pattern into the main branches of the facial nerve were similar to those in control animals suggesting precise target reinnervation. Unexpectedly, however, we found that functional recovery, estimated by vibrissal motion analysis, was incomplete at 2 months after injury and did not improve thereafter. The maximum amplitude of whisking remained substantially, by more than 30% lower than control values even 5 months after axonotmesis. Morphological analyses showed that the facial motoneurons ipsilateral to injury were innervated by lower numbers of glutamatergic terminals (-15%) and cholinergic perisomatic boutons (-26%) compared with the contralateral non-injured motoneurons. The structural deficits were correlated with functional performance of individual animals and associated with microgliosis in the facial nucleus but not with polyinnervation of muscle fibers. These results support the idea that restricted CNS plasticity and insufficient afferent inputs to motoneurons may substantially contribute to functional deficits after facial nerve injuries, possibly including pathologic conditions in humans like axonotmesis in idiopathic facial nerve (Bell's) palsy. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Crush Testing at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

Feldman, Matthew R.

2011-01-01

The dynamic crush test is required in the certification testing of some small Type B transportation packages. International Atomic Energy Agency regulations state that the test article must be 'subjected to a dynamic crush test by positioning the specimen on the target so as to suffer maximum damage.' Oak Ridge National Laboratory (ORNL) Transportation Technologies Group performs testing of Type B transportation packages, including the crush test, at the National Transportation Research Center in Knoxville, Tennessee (United States). This paper documents ORNL's experiences performing crush tests on several different Type B packages. ORNL has crush tested five different drum-type package designs, continuing its 60 year history of RAM package testing. A total of 26 crush tests have been performed in a wide variety of package orientations and crush plate CG alignments. In all cases, the deformation of the outer drum created by the crush test was significantly greater than the deformation damage caused by the 9 m drop test. The crush test is a highly effective means for testing structural soundness of smaller nondense Type B shipping package designs. Further regulatory guidance could alleviate the need to perform the crush test in a wide range of orientations and crush plate CG alignments.

Classic crush and DK crush stenting techniques.

Science.gov (United States)

Zhang, Jun-Jie; Chen, Shao-Liang

2015-01-01

Clinical data have supported the advantages of the double kissing (DK) crush technique, which consists of stenting the side branch (SB), balloon crush, first kissing, stenting the main vessel (MV) and final kissing balloon inflation, for complex coronary bifurcation lesions compared to other stenting techniques. Careful rewiring from the proximal cell of the MV stent to make sure the wire is in the true lumen of the SB stent is key to acquiring optimal angiographic results. Balloon anchoring from the MV, alternative inflation and each kissing inflation using large enough non-compliant balloons at high pressure, and the proximal optimisation technique are mandatory to improve both angiographic and clinical outcomes. Stratification of a given bifurcation lesion is recommended before decision making.

Diffusion in the pore water of compacted crushed salt

Energy Technology Data Exchange (ETDEWEB)

Fluegge, Judith; Herr, Sebastian; Lauke, Thomas; Meleshyn, Artur; Miehe, Ruediger; Ruebel, Andre

2016-07-15

Diffusion of dissolved radionuclides in the pore water of compacted crushed salt in the long-term is the most relevant process for the release of radionuclides from a dedicated repository for high-level waste in a salt formation as has been shown in latest safety assessments and research projects /BUH 16/. So far, diffusion coefficients for free water have been applied for the diffusion in pore water in models for long-term safety assessments. This conservative assumption was used, because data on the diffusion coefficient of dissolved substances in crushed salt have been missing. Furthermore, the diffusion coefficient in the pore water was assumed to be constant and independent from the degree of compaction of the crushed salt. The work presented in this report was intended to contribute to fill this gap of knowledge about how the diffusion of radionuclides takes place in the compacted backfill of a repository in salt. For the first time, the pore diffusion coefficient as well as its dependence on the porosity of the crushed salt was determined experimentally by means of through-diffusion experiments using caesium as tracer. The results achieved in this project suggest that the diffusion in compacted crushed salt is not fully comparable to that in a homogeneous, temporally stable porous medium like sand or clay. The results obtained from four diffusion experiments show a remarkably different behaviour and all yield unique concentration versus time plots which includes highly temporal variable tracer fluxes with even full interruptions of the flux for longer periods of time. This effect cannot be explained by assuming a tracer transport by diffusion in a temporarily invariant pore space and / or under temporally invariant experimental conditions. From our point of view, a restructuring of the pore space seems to lead to closed areas of pore water in the sample which may open up again after some time, leading to a variable pore space and hence variable diffusive

Assessment of Crushed Water Hyacinth ( Eichhornia crassipes ) as ...

African Journals Online (AJOL)

A preliminary study was conducted to evaluate and compare organic buffering capacity of crushed water hyacinth and calcium carbonate on acidic borehole water for aquaculture. Thirty, 25-litre shaded plastic tanks (20-litre filled with experimental water, pH 3.0) of three replicates per treatment of 180 g buffer agent were ...

Crushed Salt Constitutive Model

International Nuclear Information System (INIS)

Callahan, G.D.

1999-01-01

The constitutive model used to describe the deformation of crushed salt is presented in this report. Two mechanisms -- dislocation creep and grain boundary diffusional pressure solution -- are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. Upon complete consolidation, the crushed-salt model reproduces the Multimechanism Deformation (M-D) model typically used for the Waste Isolation Pilot Plant (WIPP) host geological formation salt. New shear consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on WIPP and southeastern New Mexico salt. Nonlinear least-squares model fitting to the database produced two sets of material parameter values for the model -- one for the shear consolidation tests and one for a combination of the shear and hydrostatic consolidation tests. Using the parameter values determined from the fitted database, the constitutive model is validated against constant strain-rate tests. Shaft seal problems are analyzed to demonstrate model-predicted consolidation of the shaft seal crushed-salt component. Based on the fitting statistics, the ability of the model to predict the test data, and the ability of the model to predict load paths and test data outside of the fitted database, the model appears to capture the creep consolidation behavior of crushed salt reasonably well

Regenerative Potential of D-δ-Tocotrienol Rich Fraction on Crushed Skeletal Muscle of Diabetic Rats

Directory of Open Access Journals (Sweden)

Bijo Elsy

2017-06-01

Full Text Available Background: Delayed muscle growth and regeneration of skeletal muscle in diabetics is believed to be due to diabetic myopathy because of alteration in the skeletal muscle homeostatis. Since vitamin E is a natural antioxidant and is also important for the integrity of sarcolemma, the present study was designed to explore the muscle regenerative potency of d-δ-tocotrienol-rich fraction (d-δ-TRF on crushed skeletal muscle in healthy and diabetic rats. Materials and Methods: Diabetes was induced through single subcutaneous injection of alloxan (100 mg/kg. Twenty-four albino rats were divided into four groups; healthy control, diabetic control, healthy treated, and diabetic treated. Treated groups received injections orally, daily (200 mg/kg for 3 weeks. A horizontal skin incision was made on the shaved right mid-thigh region, by splitting the fascia between gluteus maximus and tensor fascia lata, and gluteus maximus was crushed with Kocher’s forceps. Skin wound was closed with an absorbable suture. The crushed muscle changes were studied by assessing the histopathological features, histomorphological measurements, and biochemical analyses on 3rd week following induction of injury. One-way “ANOVA” followed by Tukey’s test and Student t-test were used for statistical analysis of data. Results: Results obtained through various methods indicate that the d-δ-TRF treated groups have controlled glycemic status, improved antioxidant capacity, faster revascularization, re-innervation, regeneration of myofibers, and connective tissue remodeling. Conclusion: It is, therefore, concluded that the d-δ-TRF is a beneficial nutritional adjuvant for skeletal muscles’ structural and functional recovery after crushed injury in both healthy and diabetics. [J Interdiscip Histopathol 2017; 5(2.000: 36-42

Injury Based on Its Study in Experimental Models

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M. Mendes-Braz

2012-01-01

Full Text Available The present review focuses on the numerous experimental models used to study the complexity of hepatic ischemia/reperfusion (I/R injury. Although experimental models of hepatic I/R injury represent a compromise between the clinical reality and experimental simplification, the clinical transfer of experimental results is problematic because of anatomical and physiological differences and the inevitable simplification of experimental work. In this review, the strengths and limitations of the various models of hepatic I/R are discussed. Several strategies to protect the liver from I/R injury have been developed in animal models and, some of these, might find their way into clinical practice. We also attempt to highlight the fact that the mechanisms responsible for hepatic I/R injury depend on the experimental model used, and therefore the therapeutic strategies also differ according to the model used. Thus, the choice of model must therefore be adapted to the clinical question being answered.

A novel motion analysis approach reveals late recovery in C57BL/6 mice and deficits in NCAM-deficient mice after sciatic nerve crush.

Science.gov (United States)

Fey, Andreas; Schachner, Melitta; Irintchev, Andrey

2010-05-01

Assessment of motor abilities after sciatic nerve injury in rodents, in particular mice, relies exclusively on walking track (footprint) analysis despite known limitations of this method. Using principles employed recently for video-based motion analyses after femoral nerve and spinal cord injuries, we have designed and report here a novel approach for functional assessments after sciatic nerve lesions in mice. Functional deficits are estimated by angle and distance measurements on single video frames recorded during beam-walking and inclined ladder climbing. Analyses of adult C57BL/6J mice after crush of the sciatic, tibial, or peroneal nerve allowed the identification of six numerical parameters, detecting impairments of the plantar flexion of the foot and the toe spread. Some of these parameters, as well as footprint functional indices, revealed severe impairment after crush injury of the sciatic or tibial, but not the peroneal nerve, and complete recovery within 3 weeks after lesion. Other novel estimates, however, showed that complete recovery is reached as late as 2-3 months after sciatic nerve crush. These measures detected both tibial and peroneal dysfunction. In contrast to the complete restoration of function in wild-type mice (100%), our new parameters, in contrast to the sciatic functional index, showed incomplete recovery (85%) 90 days after sciatic nerve crush in mice deficient in the neural cell adhesion molecule (NCAM). We conclude that the novel video-based approach is more precise, sensitive, and versatile than established tests, allowing objective numerical assessment of different motor functions in a sciatic nerve injury paradigm in mice.

Adaptation of oral medication in people institutionalized in nursing homes for whom medication is crushed: The ADECUA Study

Directory of Open Access Journals (Sweden)

Francisco Apolo Carvajal

2016-12-01

Full Text Available Purpose: To evaluate the effect of pharmacist interventions in the adaptation of pharmaceutical forms in elders institutionalized in nursing homes whose medicines are crushed, which may have a clinical relevance. Methods: Quasi-experimental, multicenter, transversal and prospective study carried out in 10 nursing homes. Subjects for whom drugs were being crushed were identified. Their treatments were reviewed in order to identify drugs that should not be crushed. In these cases, we proposed an alternative to the physician and we evaluated the degree of acceptance, its association to other variables and the pre-post adaptation index (tablets that can be crushed and capsules that can be opened/ total number of tablets and capsules before and after the intervention. Moreover, health professionals received a training course. Results: Medication was being crushed for 33% (618/1875 of residents (mean: 5 drugs susceptible of crushing. 220 pharmaceutical interventions were performed, mostly in extended release or gastro-resistant drugs (48% were accepted. Switch was the type of intervention more frequent (79%, mainly to Purpose: To evaluate the effect of pharmacist interventions in the adaptation of pharmaceutical forms in elders institutionalized in nursing homes whose medicines are crushed, which may have a clinical relevance. Methods: Quasi-experimental, multicenter, transversal and prospective study carried out in 10 nursing homes. Subjects for whom drugs were being crushed were identified. Their treatments were reviewed in order to identify drugs that should not be crushed. In these cases, we proposed an alternative to the physician and we evaluated the degree of acceptance, its association to other variables and the pre-post adaptation index (tablets that can be crushed and capsules that can be opened/ total number of tablets and capsules before and after the intervention. Moreover, health professionals received a training course. Results

Crushing method for nuclear fuel powder

International Nuclear Information System (INIS)

Hasegawa, Shin-ichi; Tsuchiya, Haruo.

1997-01-01

A crushing medium is contained in mill pots disposed at the circumferential periphery of a main axis. The diameter of each mill pot is determined such that powdery nuclear fuels containing aggregated powders and ground and mixed powders do not reach criticality. A plurality of mill pots are revolved in the direction of the main axis while each pots rotating on its axis. Powdery nuclear fuels containing aggregated powders are conveyed to a supply portion of the moll pot, and an inert gas is supplied to the supply portion. The powdery nuclear fuels are supplied from the supply portion to the inside of the mill pots, and the powdery nuclear fuels containing aggregated powders are crushed by centrifugal force caused by the rotation and the revolving of the mill pots by means of the crushing medium. UO 2 powder in uranium oxide fuels can be crushed continuously. PuO 2 powder and UO 2 powder in MOX fuels can be crushed and mixed continuously. (I.N.)

Usage of Crushed Concrete Fines in Decorative Concrete

Science.gov (United States)

Pilipenko, Anton; Bazhenova, Sofia

2017-10-01

The article is devoted to the questions of usage of crushed concrete fines from concrete scrap for the production of high-quality decorative composite materials based on mixed binder. The main problem in the application of crushed concrete in the manufacture of decorative concrete products is extremely low decorative properties of crushed concrete fines itself, as well as concrete products based on them. However, crushed concrete fines could have a positive impact on the structure of the concrete matrix and could improve the environmental and economic characteristics of the concrete products. Dust fraction of crushed concrete fines contains non-hydrated cement grains, which can be opened in screening process due to the low strength of the contact zone between the hydrated and non-hydrated cement. In addition, the screening process could increase activity of the crushed concrete fines, so it can be used as a fine aggregate and filler for concrete mixes. Previous studies have shown that the effect of the usage of the crushed concrete fines is small and does not allow to obtain concrete products with high strength. However, it is possible to improve the efficiency of the crushed concrete fines as a filler due to the complex of measures prior to mixing. Such measures may include a preliminary mechanochemical activation of the binder (cement binder, iron oxide pigment, silica fume and crushed concrete fines), as well as the usage of polycarboxylate superplasticizers. The development of specific surface area of activated crushed concrete fines ensures strong adhesion between grains of binder and filler during the formation of cement stone matrix. The particle size distribution of the crushed concrete fines could achieve the densest structure of cement stone matrix and improve its resistance to environmental effects. The authors examined the mechanisms of structure of concrete products with crushed concrete fines as a filler. The results of studies of the properties of

Characterizing large strain crush response of redwood

International Nuclear Information System (INIS)

Cramer, S.M.; Hermanson, J.C.

1996-12-01

Containers for the transportation of hazardous and radioactive materials incorporate redwood in impact limiters. Redwood is an excellent energy absorber, but only the most rudimentary information exists on its crush properties. The objectives of the study were to fill the information gap by collecting triaxial load-deformation data for redwood; to use these data to characterize redwood crush, assess current wood failure theories, provide developments toward a complete stress-strain theory for redwood; and to review the literature on strain-rate effects on redwood crush performance. The load-deformation responses of redwood at temperature conditions corresponding to ambient (70 degrees F), 150 degrees F, and -20 degrees F conditions were measured in approximately 100 confined compression tests for crush levels leading to material densification. Data analysis provided a more complete description of redwood crush performance and a basis for assessing proposed general orthotropic stress-strain relationships for redwood. A review of existing literature indicated that strain-rate effects cause at most a 20 percent increase in crush stress parallel to grain

Interaction between an Eco-Spiral Bolt and Crushed Rock in a Borehole Evaluated by Pull-Out Testing

Directory of Open Access Journals (Sweden)

Seong-Seung Kang

2017-01-01

Full Text Available The interactions between an eco-spiral bolt and crushed rocks in a borehole were evaluated by pull-out testing in a laboratory and numerical analysis. The porosity of the crushed rock surrounding the bolt depended on the size of the eco-spiral bolt and affected the eco-spiral bolt’s axial resistance force. The axial resistance force and the porosity of the crushed rocks in the borehole showed an inverse relationship. The porosity was also related to the size of the eco-spiral bolt. The maximum principal stress between the bolt and the rock was related to the porosity of the crushed rock and the size difference between the eco-spiral bolt and the borehole. At low porosity the experimental and numerical analyses show similar relationships between the axial resistance force and the displacement. However, at high porosity, the numerical results deviated greatly from the experimental observation. The initial agreement is attributed to the state of residual resistance after the maximum axial resistance force, and the latter divergence was due to the decreasing axial resistance force owing to slippage.

Crushed stone production plant for NPP building

International Nuclear Information System (INIS)

Obolenskij, V.Ya.

1982-01-01

The project of the granite-crushed stone quarry - the large modern plant producing building materials, is presented. The quarry is designated for providing NPP and other power objects building with high-strength crushed stone. The plant consists of: quarry; crushing-sorting plant with maintenance objects arranged on its ground; basis and service stores of explosive materials; tail facility and purifying systems; water supply purifying stations; water storage basin. The plant is reserved for 2335 thousand m 3 yearly utoput of crushed stone; the staff consists of 535 persons, the budgeted cost of building is 26.6 million rubles. Physicochemical characteristics of granosyenites of the ''Granitnoye'' deposit - the raw material resource base of the plant and technological scheme of the crushing-sorting plant are given. Planned measures on building organization and recultivation of disturbed grounds are presented

Protection by an oral disubstituted hydroxylamine derivative against loss of retinal ganglion cell differentiation following optic nerve crush.

Science.gov (United States)

Lindsey, James D; Duong-Polk, Karen X; Dai, Yi; Nguyen, Duy H; Leung, Christopher K; Weinreb, Robert N

2013-01-01

Thy-1 is a cell surface protein that is expressed during the differentiation of retinal ganglion cells (RGCs). Optic nerve injury induces progressive loss in the number of RGCs expressing Thy-1. The rate of this loss is fastest during the first week after optic nerve injury and slower in subsequent weeks. This study was undertaken to determine whether oral treatment with a water-soluble N-hydroxy-2,2,6,6-tetramethylpiperidine derivative (OT-440) protects against loss of Thy-1 promoter activation following optic nerve crush and whether this effect targets the earlier quick phase or the later slow phase. The retina of mice expressing cyan fluorescent protein under control of the Thy-1 promoter (Thy1-CFP mice) was imaged using a blue-light confocal scanning laser ophthalmoscope (bCSLO). These mice then received oral OT-440 prepared in cream cheese or dissolved in water, or plain vehicle, for two weeks and were imaged again prior to unilateral optic nerve crush. Treatments and weekly imaging continued for four more weeks. Fluorescent neurons were counted in the same defined retinal areas imaged at each time point in a masked fashion. When the counts at each time point were directly compared, the numbers of fluorescent cells at each time point were greater in the animals that received OT-440 in cream cheese by 8%, 27%, 52% and 60% than in corresponding control animals at 1, 2, 3 and 4 weeks after optic nerve crush. Similar results were obtained when the vehicle was water. Rate analysis indicated the protective effect of OT-440 was greatest during the first two weeks and was maintained in the second two weeks after crush for both the cream cheese vehicle study and water vehicle study. Because most of the fluorescent cells detected by bCSLO are RGCs, these findings suggest that oral OT-440 can either protect against or delay early degenerative responses occurring in RGCs following optic nerve injury.

Protection by an oral disubstituted hydroxylamine derivative against loss of retinal ganglion cell differentiation following optic nerve crush.

Directory of Open Access Journals (Sweden)

James D Lindsey

Full Text Available Thy-1 is a cell surface protein that is expressed during the differentiation of retinal ganglion cells (RGCs. Optic nerve injury induces progressive loss in the number of RGCs expressing Thy-1. The rate of this loss is fastest during the first week after optic nerve injury and slower in subsequent weeks. This study was undertaken to determine whether oral treatment with a water-soluble N-hydroxy-2,2,6,6-tetramethylpiperidine derivative (OT-440 protects against loss of Thy-1 promoter activation following optic nerve crush and whether this effect targets the earlier quick phase or the later slow phase. The retina of mice expressing cyan fluorescent protein under control of the Thy-1 promoter (Thy1-CFP mice was imaged using a blue-light confocal scanning laser ophthalmoscope (bCSLO. These mice then received oral OT-440 prepared in cream cheese or dissolved in water, or plain vehicle, for two weeks and were imaged again prior to unilateral optic nerve crush. Treatments and weekly imaging continued for four more weeks. Fluorescent neurons were counted in the same defined retinal areas imaged at each time point in a masked fashion. When the counts at each time point were directly compared, the numbers of fluorescent cells at each time point were greater in the animals that received OT-440 in cream cheese by 8%, 27%, 52% and 60% than in corresponding control animals at 1, 2, 3 and 4 weeks after optic nerve crush. Similar results were obtained when the vehicle was water. Rate analysis indicated the protective effect of OT-440 was greatest during the first two weeks and was maintained in the second two weeks after crush for both the cream cheese vehicle study and water vehicle study. Because most of the fluorescent cells detected by bCSLO are RGCs, these findings suggest that oral OT-440 can either protect against or delay early degenerative responses occurring in RGCs following optic nerve injury.

Cross-section crushing behaviour of hat-sections (Part II: Analytical modelling)

NARCIS (Netherlands)

Hofmeyer, H.

2005-01-01

Hat-sections are often used to experimentally investigate building sheeting subject to a concentrated load and bending. In car doors, hat-sections are used for side-impact protection. Their crushing behaviour can partly be explained by only observing their cross-sectional behaviour [1]. This

industrial hand injuries as seen at avenue hospital, nairobi

African Journals Online (AJOL)

The first 4 hours of the shift accounted for 39 (52%) of the injuries. ... the body in traumatic occupational injuries (1). Work-. Related Hand Injuries (WRHI) result in functional impairment .... textile industries accounting for 16.8%. Crushing was ...

Effect of crushed sand on mortar and concrete rheology

Directory of Open Access Journals (Sweden)

Cabrera, O. A.

2011-09-01

Full Text Available This article describes an experimental study conducted on fresh mortars and concretes made with crushed sand. The aim of this research was to assess the effect of aggregate particle shape and surface texture as well as dust content on mortar and concrete rheology. The experimental programme also addressed the impact of angular grains on chemical admixture performance and concrete bleeding. The findings showed that the use of crushed sand induces rheological behaviour that differs from the behaviour observed in natural sand and that superplasticisers can improve this behaviour considerably.

En el presente trabajo se plantea un estudio experimental del estado fresco de morteros y hormigones con arenas de machaqueo, orientado a la evaluación de la incidencia de la forma y textura superficial de los granos del árido fino y del contenido de polvo sobre la reología de las mezclas. El programa experimental comprendió el estudio del estado fresco de hormigones con arenas con partículas angulares, la influencia de este tipo de partículas sobre la efectividad de los aditivos químicos y la evaluación de la influencia de las características físicas del árido fino sobre la exudación. Los resultados muestran que el empleo de arenas de machaqueo provoca un comportamiento reológico diferente al de hormigones con arenas naturales, y que el efecto de los aditivos superfluidificantes mejora notablemente este comportamiento.

Gallic acid and exercise training improve motor function, nerve conduction velocity but not pain sense reflex after experimental sciatic nerve crush in male rats

Directory of Open Access Journals (Sweden)

Maryam Hajimoradi

2015-06-01

Full Text Available Objective: The aim of present study was to evaluate the effects of oral administration of gallic acid (GA for 21 days alone and in combination with exercise on nerve conduction velocity and sensory and motor functions in rats with sciatic nerve crush. Materials and Methods: Seventy adult male Wistar rats (250-300 g were divided randomly into 7 groups with 10 in each: 1 Control (Cont, 2 Crushed + Vehicle (Cr +Veh, 3-5 Crushed + gallic acid (Cr+GA (50, 100, and 200 mg/kg/2 mL, orally, 6 Crushed + exercise (Cr+Exe, and 7 Crushed + exercise + effective dose of gallic acid (Cr+Exe +GA200 for 21 days. In order to establish an animal model of sciatic nerve crush, equivalent to 7 kg of force pressed on 2-3 mm of sciatic nerve for 30 s, three times with 30 s intervals. Pain sense reflex in hot plate, motor coordination in rotarod, and sciatic nerve conduction velocity (SNCV in all groups were tested. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and pResults: Pain threshold was increased significantly in untreated crushed rats while motor function and SNCV were decreased in all groups with nerve crush (p

Studies on various characteristics of concrete structures using crushed sand

International Nuclear Information System (INIS)

Mimatsu, Makoto; Sugita, Hideaki; Yonemura, Masataka.

1985-01-01

With the recent advances of construction industry, the demands for concrete, hence for aggregate, are rising. The sand as such is in extreme shortage due to the exhaustion of river sand. Under the situation, the recent trends are for the use of crushed sand, i.e. the artificial sand obtained by crushing rocks, which have advantages of stabilized quality and adequate supplies. In building of nuclear power plants requiring large amounts of concrete, the usage of crushed sand is now unavoidable. The following are described : the situation of aggregate in Kyushu. production method of crushed sand and the quality standards, rocks used for crushed stone and sand and the properties, quality survey on crushed sand and the basic tests, characteristic tests of crushed-stone and -sand mixed concrete, the application of crushed sand in structures of the Sendai Nuclear Power Station. (Mori, K.)

Crushed Stone Operations

Data.gov (United States)

Department of Homeland Security — This map layer includes crushed stone operations in the United States. These data were obtained from information reported voluntarily to the USGS by the aggregate...

Associations between damage location and five main body region injuries of MAIS 3-6 injured occupants.

Science.gov (United States)

Tang, Youming; Cao, Libo; Kan, Steven

2014-05-08

To examine the damage location distribution of five main body region injuries of maximum abbreviated injury score (MAIS) 3-6 injured occupants for nearside struck vehicle in front-to-side impact crashes. MAIS 3-6 injured occupants information was extracted from the US-National Automotive Sampling System/Crashworthiness Data System in the year 2007; it included the head/face/neck, chest, pelvis, upper extremity and lower extremity. Struck vehicle collision damage was classified in a three-dimensional system according to the J224 Collision Deformation Classification of SAE Surface Vehicle Standard. Nearside occupants seated directly adjacent to the struck side of the vehicle with MAIS 3-6 injured, in light truck vehicles-passenger cars (LTV-PC) side impact crashes. Distribution of MAIS 3-6 injured occupants by body regions and specific location of damage (lateral direction, horizontal direction and vertical direction) were examined. Injury risk ratio was also assessed. The lateral crush zone contributed to MAIS 3-6 injured occupants (n=705) and 50th centile injury risks when extended into zone 3. When the crush extended to zone 4, the injury risk ratio of MAIS 3-6 injured occupants approached 81%. The horizontal crush zones contributing to the highest injury risk ratio of MAIS 3-6 occupants were zones 'D' and 'Y', and the injury risk ratios were 25.4% and 36.9%, respectively. In contrast, the lowest injury risk ratio was 5.67% caused by zone 'B'. The vertical crush zone which contributed to the highest injury risk ratio of MAIS 3-6 occupants was zone 'E', whose injury risk ratio was 58%. In contrast, the lowest injury risk ratio was 0.14% caused by zone 'G+M'. The highest injury risk ratio of MAIS 3-6 injured occupants caused by crush intrusion between 40 and 60 cm in LTV-PC nearside impact collisions and the damage region of the struck vehicle was in the zones 'E' and 'Y'.

Study comparing the double kissing (DK) crush with classical crush for the treatment of coronary bifurcation lesions: the DKCRUSH-1 Bifurcation Study with drug-eluting stents.

Science.gov (United States)

Chen, S L; Zhang, J J; Ye, F; Chen, Y D; Patel, T; Kawajiri, K; Lee, M; Kwan, T W; Mintz, G; Tan, H C

2008-06-01

Classical crush has a lower rate of final kissing balloon inflation (FKBI) immediately after percutaneous coronary intervention (PCI). The double kissing (DK) crush technique has the potential to increase the FKBI rate, and no prospective studies on the comparison of classical with DK crush techniques have been reported. Three hundred and eleven patients with true bifurcation lesions were randomly divided into classical (n = 156) and DK crush (n = 155) groups. Clinical and angiographic details at follow-up at 8 months were indexed. The primary end point was major adverse cardiac events (MACE) including myocardial infarction, cardiac death and target lesion revascularization (TLR) at 8 months. FKBI was 76% in the classical crush group and 100% in the DK group (P DK crush group. Cumulative 8 month MACE was 24.4% in the classical crush group and 11.4% in the DK crush group (P = 0.02). The TLR-free survival rate was 75.4% in the classical crush group and 89.5% in the DK crush group (P = 0.002). DK crush technique has the potential of increasing FKBI rate and reducing stent thrombosis, with a further reduction of TLR and cumulative MACE rate at 8 months.

Effect of a steel toe cap on forefoot injury pattern in a cadaveric model.

Science.gov (United States)

Kwon, John Y; Campbell, John T; Myerson, Mark S; Jeng, Cliff L

2011-04-01

Crush injuries to the foot are a common workplace injury and a significant source of morbidity, disability and lost wages. Many regulatory bodies including the Occupational Safety and Health Administration (OSHA) recommend the use of safety shoes in certain occupations to help protect against these occupational hazards. However there remains controversy and paucity of published data regarding the protection afforded by a steel toe cap in regards to clinical injury pattern. This study looks to investigates the protective influence of a steel toe cap on crush injuries of the forefoot. Five non-osteoporotic paired cadaver lower extremities were appropriately fitted to a standard work boot. One foot of each pair was fitted into a steel toe capped boot (designated ``ST'' group) while the other foot was fitted into an identical version of the work boot but without the protective steel toe cap (designated ``NST'' group). Each foot was crushed using a custom designed rig with a load of 150 lb dropped from a calibrated height of 3 feet to the forefoot. X-rays were obtained to assess fracture location & comminution and stress fluoroscopy was used to assess for any ligamentous Lisfranc injury. The NST group averaged 8.2 fractured bones per foot while the ST group averaged 3.6 fractured bones per foot (p = 0.001). The NST group demonstrated significantly more metatarsal fractures (3.2 fractures/foot) versus the ST group (one fracture/foot) (p = 0.020). The NST group demonstrated significantly more proximal phalanx fractures (4.2 fractures/foot) compared to the ST group (2.6 fractures/foot) (p = 0.035). Middle and distal phalanx fractures were not significantly different between the two groups. A higher percentage of the bones fractured were deemed comminuted in the NST group (53.6%) versus the ST group (38.8%) although this did not reach statistical significance. This study demonstrated that the steel toe affords protective advantages in crush injuries to the foot in limiting

Axial Crushing Behaviors of Thin-Walled Corrugated and Circular Tubes - A Comparative Study

Science.gov (United States)

Reyaz-Ur-Rahim, Mohd.; Bharti, P. K.; Umer, Afaque

2017-10-01

With the help of finite element analysis, this research paper deals with the energy absorption and collapse behavior with different corrugated section geometries of hollow tubes made of aluminum alloy 6060-T4. Literature available experimental data were used to validate the numerical models of the structures investigated. Based on the results available for symmetric crushing of circular tubes, models were developed to investigate corrugated thin-walled structures behavior. To study the collapse mechanism and energy absorbing ability in axial compression, the simulation was carried in ABAQUS /EXPLICIT code. In the simulation part, specimens were prepared and axially crushed to one-fourth length of the tube and the energy diagram of crushing force versus axial displacement is shown. The effect of various parameters such as pitch, mean diameter, corrugation, amplitude, the thickness is demonstrated with the help of diagrams. The overall result shows that the corrugated section geometry could be a good alternative to the conventional tubes.

Associations between damage location and five main body region injuries of MAIS 3–6 injured occupants

Science.gov (United States)

Tang, Youming; Cao, Libo; Kan, Steven

2014-01-01

Objectives To examine the damage location distribution of five main body region injuries of maximum abbreviated injury score (MAIS) 3–6 injured occupants for nearside struck vehicle in front-to-side impact crashes. Design and setting MAIS 3–6 injured occupants information was extracted from the US-National Automotive Sampling System/Crashworthiness Data System in the year 2007; it included the head/face/neck, chest, pelvis, upper extremity and lower extremity. Struck vehicle collision damage was classified in a three-dimensional system according to the J224 Collision Deformation Classification of SAE Surface Vehicle Standard. Participants Nearside occupants seated directly adjacent to the struck side of the vehicle with MAIS 3–6 injured, in light truck vehicles–passenger cars (LTV–PC) side impact crashes. Outcome measures Distribution of MAIS 3–6 injured occupants by body regions and specific location of damage (lateral direction, horizontal direction and vertical direction) were examined. Injury risk ratio was also assessed. Results The lateral crush zone contributed to MAIS 3–6 injured occupants (n=705) and 50th centile injury risks when extended into zone 3. When the crush extended to zone 4, the injury risk ratio of MAIS 3–6 injured occupants approached 81%. The horizontal crush zones contributing to the highest injury risk ratio of MAIS 3–6 occupants were zones ‘D’ and ‘Y’, and the injury risk ratios were 25.4% and 36.9%, respectively. In contrast, the lowest injury risk ratio was 5.67% caused by zone ‘B’. The vertical crush zone which contributed to the highest injury risk ratio of MAIS 3–6 occupants was zone ‘E’, whose injury risk ratio was 58%. In contrast, the lowest injury risk ratio was 0.14% caused by zone ‘G+M’. Conclusions The highest injury risk ratio of MAIS 3–6 injured occupants caused by crush intrusion between 40 and 60 cm in LTV–PC nearside impact collisions and the damage region of the struck

Mechanical and hydraulic behaviour of compacting crushed salt backfill at low porosities. Project REPOPERM. Phase 2

Energy Technology Data Exchange (ETDEWEB)

Kroehn, Klaus-Peter; Czaikowski, Oliver; Wieczorek, Klaus; Zhang, Chun-Liang; Moog, Helge; Friedenberg, Larissa [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Koeln (Germany); Stuehrenberg, Dieter; Heemann, Ulrich [Bundesanstalt fuer Geowissenschaften und Rohstoffe (BGR), Hannover (Germany); Jobmann, Michael; Mueller, Christian; Schirmer, Sonja [DBE Technology GmbH (DBE TEC), Peine (Germany)

2017-02-15

The compaction behavior of crushed salt has been extensively investigated by means of experimental as well as theoretical work. The readiness of numerical tools for the application to modeling the complex coupled thermo-hydro-mechanical processes in the crushed salt backfilled in a repository in salt rock has also been demonstrated. Compaction tests were performed under repository-relevant conditions. These tests were supplemented by laboratory work aiming at specific aspects of compaction. The following list covers the topics of these investigations as well as the main results. - Revisiting the determination of the porosity in relevant, past experiments (BGR). - Influence of the grain size distribution on compaction (BGR). - Triaxial compaction test with dry material at low porosities (BGR). - Investigation of the influence of humidity on compaction covers several subtopics. - Permeability associated with low porosity includes two subtopics. - Constitutive equations for two -phase flow (GRS). - Microstructural Investigations (DBE TEC). Parallel to the experimental work attention focussed on several aspects of the basics for modelling the compaction of crushed salt. This work covers checking the validity of the established numerical tools as well as exploring new methods. Topics and main results are listed here: - Development/definition and comparison of constitutive models (BGR). - Benchmark calculations (BGR and GRS). - Capability of scaling-rules for capillary pressure from the oil industry (GRS). - Application of discrete element codes to compacting crushed salt (DBE TEC). Finally, repository-relevant scenarios are discussed as a basis for a realistic but generic numerical model of brine inflow in to a converging back filled drift under a thermal gradient (GRS). This exercise demonstrates the feasibility of modelling crushed salt compaction as a fully coupled thermohydraulic-mechanical process including two-phase flow effects.

Mechanical and hydraulic behaviour of compacting crushed salt backfill at low porosities. Project REPOPERM. Phase 2

International Nuclear Information System (INIS)

Kroehn, Klaus-Peter; Czaikowski, Oliver; Wieczorek, Klaus; Zhang, Chun-Liang; Moog, Helge; Friedenberg, Larissa; Stuehrenberg, Dieter; Heemann, Ulrich; Jobmann, Michael; Mueller, Christian; Schirmer, Sonja

2017-02-01

The compaction behavior of crushed salt has been extensively investigated by means of experimental as well as theoretical work. The readiness of numerical tools for the application to modeling the complex coupled thermo-hydro-mechanical processes in the crushed salt backfilled in a repository in salt rock has also been demonstrated. Compaction tests were performed under repository-relevant conditions. These tests were supplemented by laboratory work aiming at specific aspects of compaction. The following list covers the topics of these investigations as well as the main results. - Revisiting the determination of the porosity in relevant, past experiments (BGR). - Influence of the grain size distribution on compaction (BGR). - Triaxial compaction test with dry material at low porosities (BGR). - Investigation of the influence of humidity on compaction covers several subtopics. - Permeability associated with low porosity includes two subtopics. - Constitutive equations for two -phase flow (GRS). - Microstructural Investigations (DBE TEC). Parallel to the experimental work attention focussed on several aspects of the basics for modelling the compaction of crushed salt. This work covers checking the validity of the established numerical tools as well as exploring new methods. Topics and main results are listed here: - Development/definition and comparison of constitutive models (BGR). - Benchmark calculations (BGR and GRS). - Capability of scaling-rules for capillary pressure from the oil industry (GRS). - Application of discrete element codes to compacting crushed salt (DBE TEC). Finally, repository-relevant scenarios are discussed as a basis for a realistic but generic numerical model of brine inflow in to a converging back filled drift under a thermal gradient (GRS). This exercise demonstrates the feasibility of modelling crushed salt compaction as a fully coupled thermohydraulic-mechanical process including two-phase flow effects.

27 CFR 24.176 - Crushing and fermentation.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Crushing and fermentation..., DEPARTMENT OF THE TREASURY LIQUORS WINE Production of Wine § 24.176 Crushing and fermentation. (a) Natural... fermentation but the density of the juice may not be reduced below 22 degrees Brix. However, if the juice is...

[Comparison of DK crush with classical crush technique with drug-eluting stents for the treatment of coronary bifurcation lesions from DKCRUSH-1 study].

Science.gov (United States)

Chen, Shao-liang; Zhang, Jun-jie; Ye, Fei; Chen, Yun-dai; Lü, Shu-zheng; Tan, Huaycheem; Patel, Tejas; Kenji, Kawajiri; Tamari, Israel; Shan, Shou-jie; Zhu, Zhong-sheng; Lin, Song; Tian, Nai-liang; Li, Xiao-bo; Liu, Zhi-zhong; Lee, Michael; Wei, Meng; Xu, Ya-wei; Yuan, Zheng-bai; Qian, Jun; Sun, Xue-wen; Yang, Song; Chen, Jin-guo; He, Ben; Sumit, Suji

2008-02-01

To determine independent factors correlated with clinical effects of DK crush and classical crush technique with drug-eluting stents on bifurcation lesions. 311 patients with bifurcation lesions were randomized to classical (C, n = 156) or double kissing (DK) crush (n = 155) stent implantation group. The primary endpoints included major adverse cardiac events (MACE). Final kissing balloon inflation (FKBI) success rate was 76% in C and 100% in DK groups (P DK crush procedure was characterized by lower unsatisfactory FKBI rate (27.6% vs.6.3%, P DK groups (P = 0.01), respectively. Cumulative 8-month MACE was 35.9% in without-FKBI and 19.7% in with-FKBI sub-groups, and 11.4% in DK group (P = 0.02). The incidence of stent thrombosis was 3.2% in C group (5.1% without vs. 1.7% with FKBI) and 1.3% in DK group (P > 0.05). The predictive factors of MACE included minimal side branch stent lumen diameter and lack of DK crush technique. DK crush technique is an alternative of double stenting techniques in terms of improvement of restenosis and clinical outcomes.

Guinea pigs as an animal model for sciatic nerve injury

Directory of Open Access Journals (Sweden)

Malik Abu Rafee

2017-01-01

Full Text Available The overwhelming use of rat models in nerve regeneration studies is likely to induce skewness in treatment outcomes. To address the problem, this study was conducted in 8 adult guinea pigs of either sex to investigate the suitability of guinea pig as an alternative model for nerve regeneration studies. A crush injury was inflicted to the sciatic nerve of the left limb, which led to significant decrease in the pain perception and neurorecovery up to the 4th weak. Lengthening of foot print and shortening of toe spread were observed in the paw after nerve injury. A 3.49 ± 0.35 fold increase in expression of neuropilin 1 (NRP1 gene and 2.09 ± 0.51 fold increase in neuropilin 2 (NRP2 gene were recorded 1 week after nerve injury as compared to the normal nerve. Ratios of gastrocnemius muscle weight and volume of the experimental limb to control limb showed more than 50% decrease on the 30th day. Histopathologically, vacuolated appearance of the nerve was observed with presence of degenerated myelin debris in digestion chambers. Gastrocnemius muscle also showed degenerative changes. Scanning electron microscopy revealed loose and rough arrangement of connective tissue fibrils and presence of large spherical globules in crushed sciatic nerve. The findings suggest that guinea pigs could be used as an alternative animal model for nerve regeneration studies and might be preferred over rats due to their cooperative nature while recording different parameters.

Evaluation of crushed ticagrelor tablet doses: recovery following crushing and naso-gastric tube passage ex vivo.

Science.gov (United States)

Crean, Barry; Finnie, Cindy; Crosby, Anna

2013-06-01

Orally available ticagrelor in combination with low-dose aspirin (75-100 mg/day) is indicated for adult patients with acute coronary syndromes. However, patients with swallowing difficulties may be unable to consume the currently available 90-mg tablet. It is hypothesized that ticagrelor could be given to this patient cohort as a crushed dose administered either orally or via a naso-gastric (NG) tube. To investigate the potential use of crushed ticagrelor tablets (90- and 180-mg doses) for oral dose or NG tube administration. Ticagrelor tablets (90 or 180 mg [two 90-mg tablets]) were prepared to emulate oral and NG tube administration by similar methods. For the oral dose, ticagrelor tablets were crushed using a mortar and pestle and transferred to a dosing cup. 100 mL of water was added to the mortar, stirred, and the contents were transferred to the dosing cup and stirred to form a suspension. At this stage, where the suspension would normally be administered to a patient, it was collected for high performance liquid chromatography (HPLC) analysis. The mortar was then flushed with 100 mL of water, and the contents were again transferred to the dosing cup, stirred, and collected for HPLC analysis. For the NG dose, polyvinylchloride, polyurethane, and silicone size CH10 NG tubes were used. The tablets were crushed using a mortar and pestle, diluted with 50 mL of water, and stirred. At this stage, where the suspension would normally be administered to a patient through an NG tube using a syringe, it was collected for HPLC analysis. The mortar was then flushed with two additional 50 mL aliquots of water and the contents were passed through the NG tube. HPLC analysis examined the recoverability of ticagrelor in each of the dose suspensions and flushes and the stability of the suspension when held in a syringe for up to 2 h. One or two crushed 90-mg ticagrelor tablets, prepared for either oral or NG tube administration, delivers a mean dose of ≥97% of the original

Lung Morphological Changes in Closed Chest Injury (an experimental study

Directory of Open Access Journals (Sweden)

A. M. Golubev

2012-01-01

Full Text Available Objective: to study lung morphological changes in a closed chest injury model in laboratory animals. Material and methods. Experiments were carried out in 30 male albino nonbred rats weighing 350—380 g. Closed chest injury was simulated, by exposing the chest of anesthetized rats to a 300-g metal cylinder falling from a height of 30 cm. The observation periods were 1, 3, 6, and 24 hours. Results. The signs of evident perivenular edema that was uncharas-teristic to acute respiratory distress syndrome induced by other causes are an important peculiarity of lung morphological changes in this experimental model of closed chest injury. Conclusion. The experimental studies clarified the pattern of lung morphological changes in the early period after closed chest injury. Key words: closed chest injury, pulmonary edema.

Coke properties in relation to charge preparation techniques. [Selective crushing

Energy Technology Data Exchange (ETDEWEB)

Morozov, O S

1979-01-01

Selective crushing is essential to obtain the required coke properties, so that in the coarse fractions there is a considerable reduction in the middlings and dirt normally difficult to crush. These are at the same time enriched with vitrinite so that there is an increase in the coal substance as such, reflected in improved caking capacity in the coarse size range. Various methods of selective crushing are employed, including air entrainment mills, fluidised bed systems. Other advantages claimed for selective crushing are the uniform pore distribution and air permeability and also the diminished breakage stress.

Gastrointestinal Traumatic Injuries: Gastrointestinal Perforation.

Science.gov (United States)

Revell, Maria A; Pugh, Marcia A; McGhee, Melanie

2018-03-01

The abdomen is a big place even in a small person. Gastrointestinal trauma can result in injury to the stomach, small bowel, colon, or rectum. Traumatic causes include blunt or penetrating trauma, such as gunshot wounds, stabbings, motor vehicle collisions, and crush injuries. Nontraumatic causes include appendicitis, Crohn disease, cancer, diverticulitis, ulcerative colitis, blockage of the bowel, and chemotherapy. The mechanism of injury will affect both the nature and severity of any resulting injuries. Treatment must address the critical and emergent nature of these injuries as well as issues that affect all trauma situations, which include management of hemodynamic instability. Copyright © 2017 Elsevier Inc. All rights reserved.

Micromechanics of pressure-induced grain crushing in porous rocks

Science.gov (United States)

Zhang, Jiaxiang; Wong, Teng-Fong; Davis, Daniel M.

1990-01-01

The hydrostatic compaction behavior of a suite of porous sandstones was investigated at confining pressures up to 600 MPa and constant pore pressures ranging up to 50 MPa. These five sandstones (Boise, Kayenta, St. Peter, Berea, and Weber) were selected because of their wide range of porosity (5-35%) and grain size (60-460 μm). We tested the law of effective stress for the porosity change as a function of pressure. Except for Weber sandstone (which has the lowest porosity and smallest grain size), the hydrostat of each sandstone shows an inflection point corresponding to a critical effective pressure beyond which an accelerated, irrecoverable compaction occurs. Our microstructural observations show that brittle grain crushing initiates at this critical pressure. We also observed distributed cleavage cracking in calcite and intensive kinking in mica. The critical pressures for grain crushing in our sandstones range from 75 to 380 MPa. In general, a sandstone with higher porosity and larger grain size has a critical pressure which is lower than that of a sandstone with lower porosity and smaller grain size. We formulate a Hertzian fracture model to analyze the micromechanics of grain crushing. Assuming that the solid grains have preexisting microcracks with dimensions which scale with grain size, we derive an expression for the critical pressure which depends on the porosity, grain size, and fracture toughness of the solid matrix. The theoretical prediction is in reasonable agreement with our experimental data as well as other data from soil and rock mechanics studies for which the critical pressures range over 3 orders of magnitude.

Concrete manufactured with crushed asphalt as partial replacement of natural aggregates

Directory of Open Access Journals (Sweden)

L. Coppola

2016-09-01

Full Text Available The paper focuses on the reuse of crushed asphalt (GA as a partial replacement (up to 20% of natural aggregates for concrete manufacture. Addition of GA aggregates produced a positive effect on workability loss. The GA mixes, however, showed a significant tendency to bleed and segregate at the highest replacement percentage applied. GA led to a decrease of compressive strength in concrete (with respect to that of the reference concrete up to 50% due to the weakness of the cement paste / recycled aggregate interface. To compensate for this negative effect, a reduction of w/c for the GA concretes was necessary. A decrease of w/c allowed the GA concretes to show drying shrinkage values substantially similar to those of reference concrete with the same cement factor. The experimental results confirmed the possibility of partial substitution (max. 15% of natural aggregates with crushed asphalt for making concrete.

Gallic acid and exercise training improve motor function, nerve conduction velocity but not pain sense reflex after experimental sciatic nerve crush in male rats.

Science.gov (United States)

Hajimoradi, Maryam; Fazilati, Mohammad; Gharib-Naseri, Mohammad Kazem; Sarkaki, Alireza

2015-01-01

The aim of present study was to evaluate the effects of oral administration of gallic acid (GA) for 21 days alone and in combination with exercise on nerve conduction velocity and sensory and motor functions in rats with sciatic nerve crush. Seventy adult male Wistar rats (250-300 g) were divided randomly into 7 groups with 10 in each: 1) Control (Cont), 2) Crushed + Vehicle (Cr +Veh), 3-5) Crushed + gallic acid (Cr+GA) (50, 100, and 200 mg/kg/2 mL, orally), 6) Crushed + exercise (Cr+Exe), and 7) Crushed + exercise + effective dose of gallic acid (Cr+Exe +GA200) for 21 days. In order to establish an animal model of sciatic nerve crush, equivalent to 7 kg of force pressed on 2-3 mm of sciatic nerve for 30 s, three times with 30 s intervals. Pain sense reflex in hot plate, motor coordination in rotarod, and sciatic nerve conduction velocity (SNCV) in all groups were tested. Data were analyzed using one-way ANOVA followed by Tukey's post hoc test and preflex latency was not changed in treated groups. Motor coordination and SNCV were improved in groups Cr+GA200 and Cr+Exe + GA200 (p<0.05, p<0.01 vs. Cr+Veh). GA, dose-dependently, may have therapeutic potential to improve the peripheral nerve degeneration, which is most likely related, at least in part, to its antioxidant and therapeutic properties.

Thoracic Injuries in earthquake-related versus non-earthquake-related trauma patients: differentiation via Multi-detector Computed Tomography

Directory of Open Access Journals (Sweden)

Zhi-hui Dong

2011-01-01

Full Text Available PURPOSE: Massive earthquakes are harmful to humankind. This study of a historical cohort aimed to investigate the difference between earthquake-related crush thoracic traumas and thoracic traumas unrelated to earthquakes using a multi-detector Computed Tomography (CT. METHODS: We retrospectively compared an earthquake-exposed cohort of 215 thoracic trauma crush victims of the Sichuan earthquake to a cohort of 215 non-earthquake-related thoracic trauma patients, focusing on the lesions and coexisting injuries to the thoracic cage and the pulmonary parenchyma and pleura using a multi-detector CT. RESULTS: The incidence of rib fracture was elevated in the earthquake-exposed cohort (143 vs. 66 patients in the non-earthquake-exposed cohort, Risk Ratio (RR = 2.2; p<0.001. Among these patients, those with more than 3 fractured ribs (106/143 vs. 41/66 patients, RR=1.2; p<0.05 or flail chest (45/143 vs. 11/66 patients, RR=1.9; p<0.05 were more frequently seen in the earthquake cohort. Earthquake-related crush injuries more frequently resulted in bilateral rib fractures (66/143 vs. 18/66 patients, RR= 1.7; p<0.01. Additionally, the incidence of non-rib fracture was higher in the earthquake cohort (85 vs. 60 patients, RR= 1.4; p<0.01. Pulmonary parenchymal and pleural injuries were more frequently seen in earthquake-related crush injuries (117 vs. 80 patients, RR=1.5 for parenchymal and 146 vs. 74 patients, RR = 2.0 for pleural injuries; p<0.001. Non-rib fractures, pulmonary parenchymal and pleural injuries had significant positive correlation with rib fractures in these two cohorts. CONCLUSIONS: Thoracic crush traumas resulting from the earthquake were life threatening with a high incidence of bony thoracic fractures. The ribs were frequently involved in bilateral and severe types of fractures, which were accompanied by non-rib fractures, pulmonary parenchymal and pleural injuries.

A study on the crushing behavior of basalt fiber reinforced composite structures

Science.gov (United States)

Pandian, A.; Veerasimman, A. P.; Vairavan, M.; Francisco, C.; Sultan, M. T. H.

2016-10-01

The crushing behavior and energy absorption capacity of basalt fiber reinforced hollow square structure composites are studied under axial compression. Using the hand layup technique, basalt fiber reinforced composites were fabricated using general purpose (GP) polyester resin with the help of wooden square shaped mould of varying height (100 mm, 150 mm and 200 mm). For comparison, similar specimens of glass fiber reinforced polymer composites were also fabricated and tested. Axial compression load is applied over the top end of the specimen with cross head speed as 2 mm/min using Universal Testing Machine (UTM). From the experimental results, the load-deformation characteristics of both glass fiber and basalt fiber composites were investigated. Crashworthiness and mode of collapse for the composites were determined from load-deformation curve, and they were then compared to each other in terms of their crushing behaviors.

Irreducible Fifth Metatarsophalangeal Joint after Car Crush Injury

Science.gov (United States)

Turkmensoy, Fatih; Erinc, Samet; Ergin, Omer Naci; Ozkan, Korhan; Kemah, Bahattin

2015-01-01

Metatarsophalangeal joint dislocations are uncommon injuries. Herein, an irreducible dislocation of fifth metatarsophalangeal joint with fractures on the second, third, and fourth metatarsal head was reported. Joint reduction could not be achieved which necessitated open reduction. Six months after surgery the patient was walking and doing his daily activities without any complaints. He had returned to his pretrauma functional level. PMID:25861501

Irreducible Fifth Metatarsophalangeal Joint after Car Crush Injury

Directory of Open Access Journals (Sweden)

Fatih Turkmensoy

2015-01-01

Full Text Available Metatarsophalangeal joint dislocations are uncommon injuries. Herein, an irreducible dislocation of fifth metatarsophalangeal joint with fractures on the second, third, and fourth metatarsal head was reported. Joint reduction could not be achieved which necessitated open reduction. Six months after surgery the patient was walking and doing his daily activities without any complaints. He had returned to his pretrauma functional level.

Subtle paranodal injury slows impulse conduction in a mathematical model of myelinated axons.

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Charles F Babbs

Full Text Available This study explores in detail the functional consequences of subtle retraction and detachment of myelin around the nodes of Ranvier following mild-to-moderate crush or stretch mediated injury. An equivalent electrical circuit model for a series of equally spaced nodes of Ranvier was created incorporating extracellular and axonal resistances, paranodal resistances, nodal capacitances, time varying sodium and potassium currents, and realistic resting and threshold membrane potentials in a myelinated axon segment of 21 successive nodes. Differential equations describing membrane potentials at each nodal region were solved numerically. Subtle injury was simulated by increasing the width of exposed nodal membrane in nodes 8 through 20 of the model. Such injury diminishes action potential amplitude and slows conduction velocity from 19.1 m/sec in the normal region to 7.8 m/sec in the crushed region. Detachment of paranodal myelin, exposing juxtaparanodal potassium channels, decreases conduction velocity further to 6.6 m/sec, an effect that is partially reversible with potassium ion channel blockade. Conduction velocity decreases as node width increases or as paranodal resistance falls. The calculated changes in conduction velocity with subtle paranodal injury agree with experimental observations. Nodes of Ranvier are highly effective but somewhat fragile devices for increasing nerve conduction velocity and decreasing reaction time in vertebrate animals. Their fundamental design limitation is that even small mechanical retractions of myelin from very narrow nodes or slight loosening of paranodal myelin, which are difficult to notice at the light microscopic level of observation, can cause large changes in myelinated nerve conduction velocity.

Radionuclide sorption on crushed and intact granitic rock

International Nuclear Information System (INIS)

Eriksen, Tryggve E.; Locklund, Birgitta

1989-05-01

The specific surface areas and distribution ratios for sorption of 85 Sr, 137 Cs and 152 Eu were measured for crushed and intact granite rock. The experimental data can be accommodated by a sorption model encompassing sorption on outer and inner surface. It is clearly demonstrated that the time required to obtain reliable Kd-values for the sorption of strongly sorbing radionuclides like 152 Eu is very long due to solution depletion and slow diffusion into the rock. A combination of surface area measurements and batch sorption with small particles may therefore be preferable when studying strongly sorbing nuclides. (authors) (17 figs., 6 tabs.)

Characteristics of Crushing Energy and Fractal of Magnetite Ore under Uniaxial Compression

Science.gov (United States)

Gao, F.; Gan, D. Q.; Zhang, Y. B.

2018-03-01

The crushing mechanism of magnetite ore is a critical theoretical problem on the controlling of energy dissipation and machine crushing quality in ore material processing. Uniaxial crushing tests were carried out to research the deformation mechanism and the laws of the energy evolution, based on which the crushing mechanism of magnetite ore was explored. The compaction stage and plasticity and damage stage are two main compression deformation stages, the main transitional forms from inner damage to fracture are plastic deformation and stick-slip. In the process of crushing, plasticity and damage stage is the key link on energy absorption for that the specimen tends to saturate energy state approaching to the peak stress. The characteristics of specimen deformation and energy dissipation can synthetically reply the state of existed defects inner raw magnetite ore and the damage process during loading period. The fast releasing of elastic energy and the work done by the press machine commonly make raw magnetite ore thoroughly broken after peak stress. Magnetite ore fragments have statistical self-similarity and size threshold of fractal characteristics under uniaxial squeezing crushing. The larger ratio of releasable elastic energy and dissipation energy and the faster energy change rate is the better fractal properties and crushing quality magnetite ore has under uniaxial crushing.

Axial Crushing and Energy Absorption of Empty and Foam Filled Jute-glass/ Epoxy Bi-tubes

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Khalid Asad A.

2016-01-01

Full Text Available Experimental work on the axial crushing of empty and polyurethane foam filled bi-tubular composite cone-tube has been carried out. Hand lay-up method was used to fabricate the bi-tubes using woven roving glass, jute and hybrid jute-glass/epoxy materials. The tubes were of 56 mm diameter, and the cones top diameters were 65 mm. Cone semi-apical angles of 5°, 10°, 15°, 20° and 25° were examined. Height of 120 mm was maintained for all the fabricated specimens. Effects of material used, cone semi apical angle and foam filler on the load-displacement relation, maximum load, crush force efficiency, and the specific energy absorption and failure mode were investigated. Results show that the foam filler improved the progressive crushing process, increased the maximum load and the absorbed energy of the bi-tubes. The maximum crushing load and the specific energy absorption increased with increasing the cone semi apical angle up to 20° for the empty bi-tubes and up to 25° for the foam filled bi-tubes. Progressive failure mode with fiber and matrix cracking was observed at the top narrow side of the fractured bi-tubes as well as at the bottom surface of 20° and 25° cone semi-apical angle bi-tubes.

Hydrostatic and shear consolidation tests with permeability measurements on Waste Isolation Pilot Plant crushed salt

International Nuclear Information System (INIS)

Brodsky, N.S.

1994-03-01

Crushed natural rock salt is a primary candidate for use as backfill and barrier material at the Waste Isolation Pilot Plant (WIPP) and therefore Sandia National Laboratories (SNL) has been pursuing a laboratory program designed to quantify its consolidation properties and permeability. Variables that influence consolidation rate that have been examined include stress state and moisture content. The experimental results presented in this report complement existing studies and work in progress conducted by SNL. The experiments described in this report were designed to (1) measure permeabilities of consolidated specimens of crushed salt, (2) determine the influence of brine saturation on consolidation under hydrostatic loads, and 3) measure the effects of small applied shear stresses on consolidation properties. The laboratory effort consisted of 18 individual tests: three permeability tests conducted on specimens that had been consolidated at Sandia, six hydrostatic consolidation and permeability tests conducted on specimens of brine-saturated crushed WIPP salt, and nine shear consolidation and permeability tests performed on crushed WIPP salt specimens containing 3 percent brine by weight. For hydrostatic consolidation tests, pressures ranged from 1.72 MPa to 6.90 MPa. For the shear consolidation tests, confining pressures were between 3.45 MPa and 6.90 MPa and applied axial stress differences were between 0.69 and 4.14 MPa. All tests were run under drained conditions at 25 degrees C

Crushed-salt constitutive model update

International Nuclear Information System (INIS)

Callahan, G.D.; Loken, M.C.; Mellegard, K.D.; Hansen, F.D.

1998-01-01

Modifications to the constitutive model used to describe the deformation of crushed salt are presented in this report. Two mechanisms--dislocation creep and grain boundary diffusional pressure solutioning--defined previously but used separately are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. New creep consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on Waste Isolation Pilot Plant and southeastern New Mexico salt to determine material parameters for the constitutive model. Nonlinear least-squares model fitting to data from the shear consolidation tests and a combination of the shear and hydrostatic consolidation tests produced two sets of material parameter values for the model. The change in material parameter values from test group to test group indicates the empirical nature of the model but demonstrates improvement over earlier work with the previous models. Key improvements are the ability to capture lateral strain reversal and better resolve parameter values. To demonstrate the predictive capability of the model, each parameter value set was used to predict each of the tests in the database. Based on the fitting statistics and the ability of the model to predict the test data, the model appears to capture the creep consolidation behavior of crushed salt quite well

Crushed-salt constitutive model update

Energy Technology Data Exchange (ETDEWEB)

Callahan, G.D.; Loken, M.C.; Mellegard, K.D. [RE/SPEC Inc., Rapid City, SD (United States); Hansen, F.D. [Sandia National Labs., Albuquerque, NM (United States)

1998-01-01

Modifications to the constitutive model used to describe the deformation of crushed salt are presented in this report. Two mechanisms--dislocation creep and grain boundary diffusional pressure solutioning--defined previously but used separately are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. New creep consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on Waste Isolation Pilot Plant and southeastern New Mexico salt to determine material parameters for the constitutive model. Nonlinear least-squares model fitting to data from the shear consolidation tests and a combination of the shear and hydrostatic consolidation tests produced two sets of material parameter values for the model. The change in material parameter values from test group to test group indicates the empirical nature of the model but demonstrates improvement over earlier work with the previous models. Key improvements are the ability to capture lateral strain reversal and better resolve parameter values. To demonstrate the predictive capability of the model, each parameter value set was used to predict each of the tests in the database. Based on the fitting statistics and the ability of the model to predict the test data, the model appears to capture the creep consolidation behavior of crushed salt quite well.

Constitutive behavior of reconsolidating crushed salt

International Nuclear Information System (INIS)

Callahan, G.D.; Mellegard, K.D.; Hansen, F.D.

1998-02-01

The constitutive model used to describe deformation of crushed salt is presented in this paper. Two mechanisms--dislocation creep and grain boundary diffusional pressure solutioning--are combined to form the basis for the constitutive model governing deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. Recently completed creep consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on Waste Isolation Pilot Plant (WIPP) and southeastern New Mexico salt to determine material parameters for the constitutive model. Nonlinear least-squares model fitting to data from shear consolidation tests and a combination of shear and hydrostatic tests produces two sets of material parameter values for the model. Changes in material parameter values from test group to test group indicate the empirical nature of the model but show significant improvement over earlier work. To demonstrate the predictive capability of the model, each parameter value set was used to predict each of the tests in the database. Based on fitting statistics and ability of the model to predict test data, the model appears to capture the creep consolidation behavior of crushed salt quite well

Open extensor tendon injuries: an epidemiologic study.

Science.gov (United States)

Patillo, Dominic; Rayan, Ghazi M

2012-01-01

To report the epidemiology, mechanism, anatomical location, distribution, and severity of open extensor tendon injuries in the digits, hand, and forearm as well as the frequency of associated injuries to surrounding bone and soft tissue. Retrospective chart review was conducted for patients who had operative repair of open digital extensor tendon injuries in all zones within an 11-year period. Data was grouped according to patient characteristics, zone of injury, mechanism of injury, and presence of associated injury. Statistical analysis was used to determine the presence of relevant associations. Eighty-six patients with 125 severed tendons and 105 injured digits were available for chart reviews. Patients were predominantly males (83%) with a mean age of 34.2 years and the dominant extremity was most often injured (60%). The thumb was the most commonly injured (25.7%), followed by middle finger (24.8), whereas small finger was least affected (10.5%). Sharp laceration was the most common mechanism of injury (60%), and most of these occurred at or proximal to the metacarpophalangeal joints. Most saw injuries occurred distal to the metacarpophalangeal joint. Zone V was the most commonly affected in the fingers (27%) while zone VT was the most commonly affected in the thumb (69%). Associated injuries to bone and soft tissue occurred in 46.7% of all injuries with saw and crush/avulsions being predictive of fractures and damage to the underlying joint capsule. The extensor mechanism is anatomically complex, and open injuries to the dorsum of the hand, wrist, and forearm, especially of crushing nature and those inflicted by saws, must be thoroughly evaluated. Associated injuries should be ruled out in order to customize surgical treatment and optimize outcome.

Evaluating the Psychological Concomitants of Other-Sex Crush Experiences during Early Adolescence

Science.gov (United States)

Bowker, Julie C.; Etkin, Rebecca G.

2016-01-01

Very little empirical attention has been paid to other-sex crush experiences during adolescence. As a result, it is not known whether such experiences, which appear to be relatively common, impact psychological adjustment outcomes. This two-wave (3 month interval) longitudinal study of 268 young adolescents (48% girls; M age at Time 1 = 11.84 years) examined the psychological concomitants of other-sex crush experiences (having and being viewed by others as a crush). Anxious-withdrawal and gender were evaluated as moderators. Peer nomination measures at Time 1 assessed both types of crush experiences and mutual friendship involvement, and participants completed self-report measures of loneliness and depressive symptoms at Times 1 and 2. The results from regression analyses revealed significant associations between having an other-sex crush and depressive symptoms at Time 1, after accounting for the effects of mutual friendship. Two interaction effects also revealed that crush status was a risk factor for depressive symptoms at low levels of anxious-withdrawal but a protective factor at high levels. The findings provide the first empirical evidence that other-sex crush experiences are developmentally significant during early adolescence. PMID:26984754

Experimental model of cutaneous radiation injury in rabbits

Energy Technology Data Exchange (ETDEWEB)

Meirelles, Rafael Panisi de Campos [Universidade Federal de Sao Paulo (EPM/UNIFESP), SP (Brazil). Escola Paulista de Medicina; Hochman, Bernardo [Universidade Federal de Sao Paulo (EPM/UNIFESP), SP (Brazil). Escola Paulista de Medicina. Dept. de Cirurgia; Helene Junior, Americo; Fraga, Murillo Francisco Pires [Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo (FCMSCSP), SP (Brazil). Dept. de Cirurgia. Divisao de Cirurgia Plastica; Lellis, Rute [Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo (FCMSCSP), SP (Brazil). Divisao de Patologia; Ferreira, Lydia Masako, E-mail: rpcmeirelles@yahoo.com.br, E-mail: lydia.dcir@epm.br [Universidade Federal de Sao Paulo (EPM/UNIFESP), SP (Brazil). Escola Paulista de Mediciana. Divisao de Cirugia Plastica

2013-07-01

Purpose: to describe an experimental model of cutaneous radiation injury in rabbits. Methods: on this study eight six-month-old New Zealand male rabbits, with an average weight of 2.5kg were used. They were distributed in four groups (n=2 per group). The control group did not receive radiotherapy and the others received one radiotherapy session of 2000, 3000 and 4500 cGy, respectively. Photographic analysis and histopathological evaluation of the irradiated areas were carried out. Results: after 30 days, the animals from the control group had all their hair grown. In spite of that, the animals from group 2000 cGy had a 60-day alopecia and from group 3000 cGy, a 90-day alopecia. After the 30th day, the 3000cGy group demonstrated 90-day cutaneous radiation injuries, graded 3 and 4. One of the animals from group 4500 cGy died on the 7th day with visceral necrosis. The other from the same group had total skin necrosis. A progressive reduction of glands and blood vessels count and an increase on collagen deposition was observed. Conclusion: The proposed experimental model is reproducible. This study suggests that the dosage 4500cGy is excessive and the 3000 cGy is the most effective for this experimental model of cutaneous radiation injury in rabbits. (author)

Continuous-flow leaching studies of crushed and cored SYNROC

International Nuclear Information System (INIS)

Coles, D.G.; Bazan, F.

1980-01-01

Both crushed (150 to 300 μm) and cored 1.8 mm diameter) samples of SYNROC have been leached with the single-pass continuous-flow leaching equipment. Crushed samples of Cs-hollandite were also leached in a similar experiment. Temperatures used were 25 0 C and 75 0 C and leachates were 0.03 N NaHCO 3 and distilled water. Leaching rates from SYNROC C were ranked Cs > Sr greater than or equal to Ca > Ba > Zr. A comparison of leaching rates is made between crushed SYNROC, cored SYNROC, and PNL 76-68 glass beads. Problems encountered when comparing the leaching rates of different waste forms are discussed

High-energy roller injuries to the upper extremity.

Science.gov (United States)

Askins, G; Finley, R; Parenti, J; Bush, D; Brotman, S

1986-12-01

Eleven cases of high-energy industrial roller injuries treated between 1980 and 1984 were retrospectively reviewed. The dominant extremity was affected in nine. Six patients sustained fractures and/or dislocations, and three of these patients required fasciotomies for clinical signs of impending compartment syndromes. All fracture/dislocations, with the exception of a scapula fracture, anterior dislocation of a thumb interphalangeal joint, and a fractured coronoid process of the ulna, required open reduction with internal fixation. Three patients required split-thickness skin grafting for extensive skin degloving. Two patients required immediate amputation. Late sequelae included prolonged edema, nutritional depletion, neuroma formation of the superficial branch of the radial nerve, late carpal tunnel syndrome, and partial brachial plexus palsy. Industrial roller injuries continue to be an occupational hazard associated with more severe crushing trauma than the low-energy wringer washer injuries first described by MacCollum (11). Attention must be paid to the treatment of crushed skin, muscle, and nerves, fracture stabilization, nutritional support, and occupational therapy. Concurrent monitoring for signs of a developing compartment syndrome and complications of rhabdomyolysis is essential.

Gas adsorption on crushed quartz and basalt. [in vacuum

Science.gov (United States)

Barker, C.; Torkelson, B. E.

1975-01-01

The new surfaces generated by crushing rocks and minerals adsorb gases. Different gases are adsorbed to different extents so that both the total amount and composition of the released gases are changed. This affects the interpretation of the composition of the gases obtained by vacuum crushing lunar basalts, meteorites and minerals with fluid inclusions.

Crushing Strength of Ship Structures

DEFF Research Database (Denmark)

Cerup-Simonsen, Bo; Abramowicz, W.; Høstgaard-Brene, C.N.S.

1999-01-01

The crushing response of ship structures is of primary importance to the designers and practicing engineers concerned with accidental loading and accident reconstruction of marine vehicles. Ship to-ship collisions, ship-harbor infrastructure interaction or ship-offshore structure interaction are ...

Crushing strength of HTGR fuel particles

International Nuclear Information System (INIS)

Lackey, W.J.; Stinton, D.P.; Davis, L.E.; Beatty, R.L.

1976-01-01

The whole-particle crushing strengths of High-Temperature Gas-Cooled Reactor fertile and fissile coated particles were measured and correlated with fabrication procedures. The crushing strength of Biso-coated fertile particles was increased by the following factors: (1) increasing the outer coating thickness by 10 μm increased strengths by 0.3 lb (1.3 N) for annealed particles and by 0.5 lb (2.2 N) for unannealed particles. (2) An 1800 0 C postcoating anneal increased strengths by 1 lb (4.4 N) for particles with thick outer coatings and by 2 lb (8.9 N) for particles having thin coatings. (3) Increasing the inner coating density by 0.1 g/cm 3 increased strength by 0.6 lb (2.7 N). The crushing strength of Triso-coated fissile particles was proportional to the thickness of the SiC coatings, and strength decreased on annealing by about 0.2 lb (0.9 N) when a porous plate was used to distribute the coating gas and by about 1.5 lb (6.7 N) when a conical gas distributor was used. The strengths of fertile and fissile coated particles as well as uncoated kernels appear adequate to allow fuel fabrication without excessive particle damage

Evaluation of using crushed brick as coarse aggregate in concrete layer within rigid highway pavement

Directory of Open Access Journals (Sweden)

Alwash Ali

2018-01-01

Full Text Available Most of the present studies related to the field of highway pavement construction technique tend to make use of the local available materials as substitutes for the imported and necessary materials for some of the practical application. For this reason this research aims at looking for the prospect of used locally available aggregate such as crushed clay bricks for the aim of producing proper concrete with suitable thermal and mechanical properties. Experimental investigations have been carried out to asses the effect of partial replacement of coarse aggregate by free manually crushed Brick with percentages (10, 20, 30 and 40% of virgin coarse aggregate in concrete mix for highway rigid pavement. While the percentage (0% replacement represent reference mix. Mix proportion based on the target of compressive strength for all replacement percentage of (33 MPa at (28 days to achieve AASHTO requirement for highway concrete rigid pavement .The results of flexural strength, modulus of elasticity, density and thermal conductivity refers to better performance (less thickness of concrete layer with large spacing between contraction or expansion joints and less stresses due to warping induced concrete layer for concrete mix with 20% crushed brick as replacement of coarse aggregate.

Rogue-Elephant-Inflicted Panfacial Injuries: A Rare Case Report

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Santosh Kumar Yadav

2012-01-01

Full Text Available Attacks by elephants, the largest of the “large animals,” produce many fatalities a year. Most attacks are provoked, although rogue elephants are occasionally responsible. Trampling, goring, tossing the individual with the trunk, or crushing with the knees produces the injuries. Injuries from encounters with large animals represent a significant health risk for rural communities. Wild-animal-inflicted maxillofacial injuries are rare, and limited literature is available describing their management. We present a case of severe maxillofacial injuries caused by the attack of a rogue elephant.

Effect of crumb rubber on the mechanical properties of crushed recycled pavement materials.

Science.gov (United States)

Li, Jie; Saberian, Mohammad; Nguyen, Bao Thach

2018-07-15

The low-carbon footprint of using recycled construction and demolition (C&D) aggregates in civil engineering infrastructure applications has been considered to be a significant solution for the replacement of conventional pavement aggregates. Investigations regarding the use of crumb rubber in the base and subbase layers of pavement have been well documented. However, information on the effects of crumb rubber and its size within C&D aggregates as the base/subbase layers is still very limited. In this study, crumb rubber with particle sizes ranging from 400 to 600 μm (fine) to 10-15 mm (coarse), 20 mm recycled crushed concrete (RCC), and 20 mm crushed rock (CR) were used. The crumb rubber was added to the two groups of C&D aggregates at 0.5, 1 and 2% by weight percentages of the aggregates. The effect of crumb rubber on the mechanical properties (such as California bearing ratio, unconfined compressive strength, aggregate crushing value, dynamic lightweight cone penetrometer, Clegg impact value, Los Angeles abrasion values, and resilient modulus) of the C&D aggregates was then examined. Based on the experimental test results, it was found that crumb rubber can be recycled as a waste material for the base and subbase layers in the pavement. Copyright © 2018 Elsevier Ltd. All rights reserved.

The effect of proposed crush tests on transport containers

International Nuclear Information System (INIS)

1984-09-01

Crush tests were performed on two AECL F112 packaging specimens, two simulated AECL-CRNL 4H packaging specimens, and on empty steel drums. The 9 m drop test was carried out on two simulated AECL-CRNL 4H packaging specimens for comparison with the effects of the crush test. The tests were filmed using high speed photography and 35mm still photographs

Saturday night palsy or Sunday morning hangover? A case report of alcohol-induced Crush Syndrome.

LENUS (Irish Health Repository)

Devitt, Brian M

2011-01-01

Saturday night palsy is a colloquial term given to brachial plexus injuries of the arm resulting from stretching or direct pressure against a firm object, often after alcohol or drug consumption. In most circumstances, this condition gives rise to a temporary plexopathy, which generally resolves. However, if the compression is severe and prolonged, a more grave form of this condition known as \\'Crush Syndrome\\' may occur. Skeletal muscle injury, brought about by protracted immobilization, leads to muscle decay, causing rhabdomyolysis, which may in turn precipitate acute renal failure. This condition is potentially fatal and has an extremely high morbidity. The case presented below demonstrates the drastic consequences that can result following an episode of \\'binge\\' drinking in a young man. What is most concerning is that this trend is increasing across society and cases like this may not be as rare in the future.

Preparation-induced errors in EPR dosimetry of enamel: pre- and post-crushing sensitivity

International Nuclear Information System (INIS)

Haskell, E.H.; Hayes, R.B.; Kenner, G.H.

1996-01-01

Errors in dose estimation as a function of grain size for tooth enamel has been previously shown for beta irradiation after crushing. We tested the effect of gamma radiation applied to specimens before and after crushing. We extend the previous work in that we found that post-crushing irradiation altered the slope of the dose-response curve of the hydroxyapatite signal and produced a grain-size dependent offset. No changes in the slope of the dose-response curve were seen in enamel caps irradiated before crushing

Assessment of crushed-recycled glass as filter media for drinking water treatment

International Nuclear Information System (INIS)

Rutledge, S.O.; Fahie, C.; Gagnon, G.A.

2002-01-01

The objective of this project was to evaluate the performance of a pressure filter utilizing crushed glass as the filter media. The performance of the crushed glass filter was compared to that of a sand filter. The research was conducted in Orangedale, Nova Scotia, which is a small community of with a population of approximately 500. Orangedale is located on the south shore of Bras d'Or Lakes and feeds into Miller Pond, which serves as the source the of drinking water. The Orangedale treatment plant produces an average daily flow of 35 m3/d (6.4-gpm). The treatment plant consists of coagulation (sodium aluminate and polyaluminum chloride), flocculation, dissolved air flotation (DAF), disinfection with sodium hypochlorite and dual-media filtration with anthracite and sand. In general, the particle removal capabilities of the crushed glass filter were slightly poorer than that of a sand filter, as quantified in a field application in the community of Orangedale, Nova Scotia. It was found that the crushed glass used in this project had a higher angularity and slightly higher uniformity coefficient. During initial start-up the performance of the crushed glass filter was more variable and appeared to improve as the glass began to wear. After six-months of use the crushed glass filter was able to produce a very consistent filter effluent that was only slightly greater than the silica sand filter. After six-months of use, the sand filter achieved a 1.6 log-removal of particles with diameters greater than 2 μm; whereas the crushed glass filter achieved a 1.4 log removal for the similar particle size range. The observed removal performance was particularly encouraging given that the sand used had properties that were consistent with the standards set by the American Water Works Association. The crushed glass filter media was initially sieved and washed, but had no other pre-treatment preparation. Thus the application of crushed glass shows considerable promise as filter

Investigation on Compressive Strength of Special Concrete made with Crushed Waste Glass

Directory of Open Access Journals (Sweden)

Mohd Sani Mohd Syahrul Hisyam

2015-01-01

Full Text Available Special concrete is the type of concrete that produced by using waste material or using unusual techniques/method of preparation. Special concrete made with waste material is becoming popular in a construction site. This is because the special concrete is selected due to quality, integrity, economic factor and environmental factor. The waste glass is selected as an additional material to provide a good in compressive strength value. The compressive strength is the importance of mechanical properties of concrete and typically the concrete is sustained and stiffed in compression load. The significant issue to utilize the waste glass from the automotive windscreen is to improve the strength of concrete. The waste glass is crushed to become 5 mm size and recognised as crushed waste glass that be used in concrete as additional material. The main objective of the study is to determine the appropriate percentage of crushed waste glass in concrete grade, 30 in order to enhance the compressive strength. There are four mixes of concrete that contained of crushed waste glass with percentage of 2 %, 4 %, 6 % and 8 % and one control mix with 0 % of crushed waste glass. As the result, crushed waste glass with an additional 4 % in concrete is reported having a higher value of compressive strength in early and mature stage. In addition, if the percentage of crushed glass wastes in concrete increases and it leads to a reduction in the workability of concrete.

Research for the development of the crushed sand (II)

Energy Technology Data Exchange (ETDEWEB)

Park, Chul Whan; Kang, Sun Duck; Min, Jeong Sik; Synn, Joong Ho; Park, Chan [Korea Institute of Geology Mining and Materials, Taejon (Korea)

1998-12-01

The sand obtained from river is not sufficient in amount for the demand of construction industry. The production of sand from sea and mountain is rapidly increasing for the substitution of the river sand. The industry of the crushed sand has recently been bricked for the above. Crushing, classification and dewatering are the main processes in the crushed sand production. This report concentrates the improvement of classification technology and the quality of ready mixed concrete. Air separator with testing size for the classification in the process of dry system was developed by the Yeung Nam university. This plant has the excellent efficiency for the collection of fine powder, but needs the improvement for separating function. The collection efficiency of the testing size air separator is reached to 99% in the condition of high revolution and low feeding speed. The classification efficiency is checked about 50% maximum in the condition of 200 rpm and dry sample. Energy saving test was carried out in the production process of the dry system with the rock samples of 14-17% of water content. The classification efficiency for dewatering sample passed the heating process was analysed 91.5%. But that for high water content sample skipped the heating process was analysed more or less 77%. Even though the heating process causes the classification efficiency being high, the energy consumption can also cause the price of the crushed sand high. Water content of sample as the effective element for the optimization of classification efficiency and energy saving should be studied next year. The quality of crushed sand in the mixing design. The test was carried out with the various content in mixing, the strength of ready mixed concrete has the maximum for the mould with 50-60% content of crushed sand. This strength is higher by 5-30% than 30% content and by 20-32% than 0% content, which means that the industry has the possibility of progress. (author). 10 refs., 31 tabs., 49

The Burden of Hand Injuries at a Tertiary Hospital in Sub-Saharan Africa

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P. Makobore

2015-01-01

Full Text Available Background. Hand injuries are common worldwide and lead to heavy financial losses in terms of treatment, job loss, and time off duty. There is paucity of data on hand injuries in sub-Saharan Africa. The aim of this study was to determine the burden and early outcomes of hand injuries at a tertiary hospital. Method. A descriptive prospective study. Eligible patients were recruited over 5 months and followed up for four weeks. Pain, nerve function, and gross functions of the hand were assessed. Results. In total 138 patients were enrolled out of 2940 trauma patients. Of these, 122 patients returned for follow-up. The majority of the patients were males (83%. Mean age was 26.7 years (SD 12.8. The commonest places of injury occurrence were the workplace (36%, home (28%, and on the road (traffic crushes (23%. Machines (21.3% were the commonest agent of injuries; others were knives (10% and broken glass (10%. Sixty-three (51% patients still had pain at one month. Conclusions. Hand injuries accounted for 4.7% of all trauma patients. Road traffic crushes and machines were the commonest causes of hand injuries. Men in their 20s were mostly involved. Sensitization for prevention strategies at the workplace may be helpful.

Assessment of Clinical Practices for Crushing Medication in Geriatric Units.

Science.gov (United States)

Fodil, M; Nghiem, D; Colas, M; Bourry, S; Poisson-Salomon, A-S; Rezigue, H; Trivalle, C

2017-01-01

To assess the modification of the form of medication and evaluate staff observance of good clinical practices. One-day assessment of clinical practices. 17 geriatrics units in the 3 Teaching Hospitals of Paris-Sud (APHP), France. Elderly in-patients with difficulties swallowing capsules and tablets. Assessment of target-patient prescriptions and direct observation of nurses' medical rounds. 155/526 in-patients (29.5%) were unable to swallow tablets or capsules: 98 (40.3%) in long-term care, 46 patients (23.8%) in the rehabilitation unit and 11 (12.2%) in the acute care unit (p = .005). In thirty-nine (27.3%) of the 143 prescriptions studied all tablets were safe to crush and all capsules were safe to open. In 104 cases, at least one medication could not be safely modified, including 26 cases (18.2%) in which none of the prescribed drugs were safe to crush or open. In 48.2% of the 110 medications that were crushed, crushing was forbidden, and presented a potential threat in 12.7% of cases or a reduced efficacy in 8.2% of cases. Crushing methods were rarely appropriate: no specific protective equipment was used (81.8%), crushing equipment was shared between patients without cleaning (95.1%), medications were spilled or lost (69.9%). The method of administration was appropriate (water, jellified water) in 25% of the cases, questionable (soup, coffee, compote, juice, cream) in 55% of the cases and unacceptable (laxative) in 21% of the cases. Management of drug prescriptions in patients with swallowing difficulties is not optimal, and may even have iatrogenic effects. In this study, 12.7% of the modifications of the drug form could have been harmful. Doctors, pharmacists and nurses need to reevaluate their practices.

Injury Characteristics of Low-Energy Lisfranc Injuries Compared With High-Energy Injuries.

Science.gov (United States)

Renninger, Christopher H; Cochran, Grant; Tompane, Trevor; Bellamy, Joseph; Kuhn, Kevin

2017-09-01

Lisfranc injuries result from high- and low-energy mechanisms though the literature has been more focused on high-energy mechanisms. A comparison of high-energy (HE) and low-energy (LE) injury patterns is lacking. The objective of this study was to report injury patterns in LE Lisfranc joint injuries and compare them to HE injury patterns. Operative Lisfranc injuries were identified over a 5-year period. Patient demographics, mechanism of injury, injury pattern, associated injuries, missed diagnoses, clinical course, and imaging studies were reviewed and compared. HE mechanism was defined as motor vehicle crash, motorcycle crash, direct crush, and fall from greater than 4 feet and LE mechanism as athletic activity, ground level twisting, or fall from less than 4 feet. Thirty-two HE and 48 LE cases were identified with 19.3 months of average follow-up. There were no differences in demographics or missed diagnosis frequency (21% HE vs 18% LE). Time to seek care was not significantly different. HE injuries were more likely to have concomitant nonfoot fractures (37% vs 6%), concomitant foot fractures (78% vs 4%), cuboid fractures (31% vs 6%), metatarsal base fractures (84% vs 29%), displaced intra-articular fractures (59% vs 4%), and involvement of all 5 rays (23% vs 6%). LE injuries were more commonly ligamentous (68% vs 16%), with fewer rays involved (2.7 vs 4.1). LE mechanisms were a more common cause of Lisfranc joint injury in this cohort. These mechanisms generally resulted in an isolated, primarily ligamentous injury sparing the lateral column. Both types had high rates of missed injury that could result in delayed treatment. Differences in injury patterns could help direct future research to optimize treatment algorithms. Level III, comparative series.

Effect of crushing temperature on virgin olive oil quality and composition

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Ö. Kula

2018-03-01

Full Text Available The objective of the current study was to assess the influence of a modified crushing process and kneading operation on the quality parameters, volatile compounds, and the fatty acid and sterol profiles of virgin olive oil from the Edremit yaglik variety. In the study, olive oil samples were produced in two different processes. The first one was produced without malaxation and the second one was produced with the malaxing process. During crushing, the effect of different temperatures was tested. The results demonstrate that different crushing temperatures generally did not affect the amount of free fatty acids, or peroxide value. Total phenol contents were positively affected by the additional malaxation process. Fatty acids and sterol composition were not significantly altered at different crushing temperatures or during the subsequent malaxation application. PCA enabled a clear classification of the oils obtained from different processing techniques.

Physical, mechanical and thermal properties of Crushed Sand Concrete containing Rubber Waste

Directory of Open Access Journals (Sweden)

Mohamed Guendouz

2018-01-01

Full Text Available Over the past twenty years, the rubber wastes are an important part of municipal solid waste. This work focuses on the recycling of rubber waste, specifically rubber waste of used shoes discharged into the nature and added in the mass of crushed sand concrete with percentage (10%, 20%, 30% and 40%. The physical (workability, fresh density, mechanical (compressive and flexural strength and thermal (thermal conductivity of different crushed sand concrete made are analyzed and compared to the respective controls. The use of rubber waste in crushed sand concrete contributes to reduce the bulk density and performance of sand concrete. Nevertheless, the use of rubber aggregate leads to a significant reduction in thermal conductivity, which improves the thermal insulation of crushed sand concrete.

Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush

Energy Technology Data Exchange (ETDEWEB)

Wu, Weijie, E-mail: 459586768@qq.com; Liu, Yuxi, E-mail: 924013616@qq.com; Wang, Youhua, E-mail: wyouhua1516@163.com

2016-05-13

Sam68 (Src-associated in mitosis of 68 kD), a KH domain RNA-binding protein, is not only important in signaling transduction cascades, but crucial in a variety of cellular processes. Sam68 is reported to be involved in the phospoinositide3-kinase (PI3K) and nuclear factor-kappa B (NF-κB) signaling pathways, and it is closely associated with cell proliferation, RNA metabolism, and tumor progression. However, we know little about the role of Sam68 during peripheral nervous system injury and regeneration. In this study, we investigated the expression of Sam68 and its biological significances in sciatic nerve crush. Interestingly, we found Sam68 had a co-localization with S100 (Schwann cell marker). Moreover, after crush, Sam68 had a spatiotemporal protein expression, which was in parallel with proliferation cell nuclear antigen (PCNA). In vitro, we also observed increased expression of Sam68 during the process of TNF-α-induced Schwann cell proliferation model. Besides, flow cytometry analyses, CCK-8, and EDU were all performed with the purpose of investigating the role of Sam68 in the regulation of Schwann cell proliferation. Even more importantly, we discovered that Sam68 could enhance the phosphorylation of Akt while LY294002 (a PI3K inhibitor) obviously reversed Sam68-induced cell proliferation. Finally, we detected the variance during regeneration progress through the rat walk footprint test. In summary, all these evidences demonstrated that Sam68 might participate in Schwann cell proliferation partially via PI3K/Akt pathway and also regulate regeneration after sciatic nerve crush. -- Highlights: •The dynamic changes and location of Sam68 after sciatic nerve crush. •Sam68 promoted Schwann cell proliferation via PI3K/Akt pathway. •Sam68 modulated functional recovery after sciatic nerve crush.

Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush

International Nuclear Information System (INIS)

Wu, Weijie; Liu, Yuxi; Wang, Youhua

2016-01-01

Sam68 (Src-associated in mitosis of 68 kD), a KH domain RNA-binding protein, is not only important in signaling transduction cascades, but crucial in a variety of cellular processes. Sam68 is reported to be involved in the phospoinositide3-kinase (PI3K) and nuclear factor-kappa B (NF-κB) signaling pathways, and it is closely associated with cell proliferation, RNA metabolism, and tumor progression. However, we know little about the role of Sam68 during peripheral nervous system injury and regeneration. In this study, we investigated the expression of Sam68 and its biological significances in sciatic nerve crush. Interestingly, we found Sam68 had a co-localization with S100 (Schwann cell marker). Moreover, after crush, Sam68 had a spatiotemporal protein expression, which was in parallel with proliferation cell nuclear antigen (PCNA). In vitro, we also observed increased expression of Sam68 during the process of TNF-α-induced Schwann cell proliferation model. Besides, flow cytometry analyses, CCK-8, and EDU were all performed with the purpose of investigating the role of Sam68 in the regulation of Schwann cell proliferation. Even more importantly, we discovered that Sam68 could enhance the phosphorylation of Akt while LY294002 (a PI3K inhibitor) obviously reversed Sam68-induced cell proliferation. Finally, we detected the variance during regeneration progress through the rat walk footprint test. In summary, all these evidences demonstrated that Sam68 might participate in Schwann cell proliferation partially via PI3K/Akt pathway and also regulate regeneration after sciatic nerve crush. -- Highlights: •The dynamic changes and location of Sam68 after sciatic nerve crush. •Sam68 promoted Schwann cell proliferation via PI3K/Akt pathway. •Sam68 modulated functional recovery after sciatic nerve crush.

Mole gun injury.

Science.gov (United States)

Pistré, V; Rezzouk, J

2013-09-01

A mole gun is a weapon, which is used to trap and kill moles. This report provides an overview of the state of knowledge of mole gun injuries, comparable to blast injuries caused by fireworks, explosive or gunshot. Over a 2-year period, the authors reported their experience with ten hand injuries caused by mole gun. Radial side of the hand was often concerned, particularly the thumb. The authors explain their choices in the management of such lesions. Surgery was performed primarily and a large debridement currently seemed to offer the best outcome for the patient. Blast, crush, burns and lacerations may explain the higher rate of amputation to the digits. A long period of physiotherapy, specifically of the hand, was needed before the patient could return to work. This ballistic hand trauma encountered by surgeons requires knowledge and understanding of these injuries. It should be in accordance with firearms law because of severe injuries encountered and possible lethal wounds. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Evaluation of constitutive models for crushed salt

International Nuclear Information System (INIS)

Callahan, G.D.; Loken, M.C.; Hurtado, L.D.; Hansen, F.D.

1996-01-01

Three constitutive models are recommended as candidates for describing the deformation of crushed salt. These models are generalized to three-dimensional states of stress to include the effects of mean and deviatoric stress and modified to include effects of temperature, grain size, and moisture content. A database including hydrostatic consolidation and shear consolidation tests conducted on Waste Isolation Pilot Plant (WIPP) and southeastern New Mexico salt is used to determine material parameters for the models. To evaluate the capability of the models, parameter values obtained from fitting the complete database are used to predict the individual tests. Finite element calculations of a WIPP shaft with emplaced crushed salt demonstrate the model predictions

Quality control chart for crushed granite concrete

Directory of Open Access Journals (Sweden)

Ewa E. DESMOND

2016-07-01

Full Text Available A chart for assessing in-situ grade (strength of concrete, has been developed in this study. Four grades of concrete after the Nigerian General Specification for Roads and bridges (NGSRB-C20, C25, C30 and C35, is studied at different water-cement ratios for medium and high slump range. The concrete mixes are made from crushed granite rock as coarse aggregate with river sand as fine aggregate. Compression test on specimens are conducted at curing age of 1, 3, 7, 14, 21, 28 and 56 days. Results on concrete workability from slump values, and water-cement ratios revealed that specimens with lower water-cement ratio were less workable but had higher strength, compared to mixes with higher water cement ratio. A simple algorithm using nonlinear regression analysis performed on each experimental data set produced Strength-Age (S-A curves which were used to establish a quality control chart. The accuracy of these curves were evaluated by computing average absolute error (AAS, the error of estimate (EoE and the average absolute error of estimate (Abs EoE for each concrete mix. These were done based on the actual average experimental strengths to measure how close the predicted values are to the experimental data set. The absolute average error of estimate (Abs. EoE recorded was less than ±10% tolerance zone for concrete works.

Mitigating the Health Risks of Stone Quarrying and Crushing in India ...

International Development Research Centre (IDRC) Digital Library (Canada)

Safety and health in the stone crushing industry : a practical manual for preventing accidents preserving health and keeping a company profitable. Études. Abstract for oral presentation : addressing health risk of communities residing close to stone quarrying and crushing unit using ecohealth framework in Central India.

49 CFR 587.15 - Verification of aluminum honeycomb crush strength.

Science.gov (United States)

2010-10-01

... analog or digital form for each sample tested. If analog data are collected, a means of converting the data to digital data must be made available. All digital data are collected at a rate consistent with... all data prior to 6.4 mm (0.25 in) of crush and after 16.5 mm (0.65 in) of crush. Divide the remaining...

[Experimental model of severe local radiation injuries of the skin after X-rays].

Science.gov (United States)

Kotenko, K V; Moroz, B B; Nasonova, T A; Dobrynina, O A; LIpengolz, A A; Gimadova, T I; Deshevoy, Yu B; Lebedev, V G; Lyrschikova, A V; Eremin, I I

2013-01-01

The experimental model of severe local radiation injuries skin under the influence of a relatively soft X-rays on a modified device RAP 100-10 produced by "Diagnostica-M" (Russia) was proposed. The model can be used as pre-clinical studies in small experimental animals in order to improve the treatment of local radiation injuries, especially in the conditions of application of cellular therapy.

The diffusivity of cesium, strontium, carbon and nickel in concrete and mixtures of sodium bentonite and crushed rock

International Nuclear Information System (INIS)

Muurinen, A.; Penttilae-Hiltunen, P.; Rantanen, J.

1986-07-01

The engineering barriers suggested to be used for the disposal of low and intermediate level wastes in Finland are concrete and crushed rock or mixtures of crushed rock and bentonite. In the repository the barriers are saturated by groundwater and radionuclides may be released by diffusion through the barries. For safety analysis, the mechanisms by which the nuclides migrate and corresponding parameters should be known. In this study diffusion measurements on different types of concrete and mixtures of sodium bentonite and crushed rock were carried out. Radioactive isotopes of cesium, strontium, carbon and nickel were used as tracers. The apparent diffusivities (Dsub(a)) were evaluated on the basis of the measurements. The apparent diffusivity of cesium in concretes was 10 -14 ...10 -15 m 2 /s. Strontium was mainly sorbed on cement where it diffuses slowly. Part of strontium propably penetrates in the rock ballast by diffusion. The diffusivities of carbon and nickel in the concrete was low. The upper limit was evaluated to be Dsub(a) -14 m 2 /s. The diffusivity of cesium in the mixtures of crushed rock and bentonite varies between 0.5x10 -12 and 7x10 -12 m 2 /s. Cesium was mainly sorbed on the rock. The diffusivity of strontium was 2x10 -11 ...2x10 -12 m 2 /s. Strontium was mainly sorbed on bentonite. The diffusion of the sorbed ions (surface diffusion) seems to be a additional migration mechanism in the case of cesium and strontium in the mixture of bentonite and crushed rock. The diffusivity of carbon in the mixtures of crushed rock and bentonite was 6x10 -11 ...4x10 -12 m 2 /s. No sorption was found in the case of carbon. The measured Dsub(a) of nickel in the mixtures of crushed rock and bentonite was 4x10 -14 ...2x10 -15 m 2 /s. The experimental arrangement was not, however, in the stationary state and the more correct values would propably be 10 -13 ...10 -14 m 2 /s. No surface diffusion was found in the case of nickel. (author)

Crush Can Behaviour as an Energy Absorber in a Frontal Impact

International Nuclear Information System (INIS)

Bhuyan, Atanu; Ganilova, Olga

2012-01-01

The work presented is devoted to the investigation of a state-of-the-art technological solution for the design of a crush-can characterized by optimal energy absorbing properties. The work is focused on the theoretical background of the square tubes, circular tubes and inverbucktube performance under impact with the purpose of design of a novel optimized structure. The main system under consideration is based on the patent US 2008/0185851 A1 and includes a base flange with elongated crush boxes and back straps for stabilization of the crush boxes with the purpose of improvement of the energy-absorbing functionality. The modelling of this system is carried out applying both a theoretical approach and finite element analysis concentrating on the energy absorbing abilities of the crumple zones. The optimization process is validated under dynamic and quasi-static loading conditions whilst considering various modes of deformation and stress distribution along the tubular components. Energy absorbing behaviour of the crush-cans is studied concentrating on their geometrical properties and their diamond or concertina modes of deformation. Moreover, structures made of different materials, steel, aluminium and polymer composites are considered for the material effect analysis and optimization through their combination. Optimization of the crush-can behaviour is done within the limits of the frontal impact scenario with the purpose of improvement of the structural performance in the Euro NCAP tests.

Crush Can Behaviour as an Energy Absorber in a Frontal Impact

Science.gov (United States)

Bhuyan, Atanu; Ganilova, Olga

2012-08-01

The work presented is devoted to the investigation of a state-of-the-art technological solution for the design of a crush-can characterized by optimal energy absorbing properties. The work is focused on the theoretical background of the square tubes, circular tubes and inverbucktube performance under impact with the purpose of design of a novel optimized structure. The main system under consideration is based on the patent US 2008/0185851 A1 and includes a base flange with elongated crush boxes and back straps for stabilization of the crush boxes with the purpose of improvement of the energy-absorbing functionality. The modelling of this system is carried out applying both a theoretical approach and finite element analysis concentrating on the energy absorbing abilities of the crumple zones. The optimization process is validated under dynamic and quasi-static loading conditions whilst considering various modes of deformation and stress distribution along the tubular components. Energy absorbing behaviour of the crush-cans is studied concentrating on their geometrical properties and their diamond or concertina modes of deformation. Moreover, structures made of different materials, steel, aluminium and polymer composites are considered for the material effect analysis and optimization through their combination. Optimization of the crush-can behaviour is done within the limits of the frontal impact scenario with the purpose of improvement of the structural performance in the Euro NCAP tests.

Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells

Directory of Open Access Journals (Sweden)

Louise A. Mesentier-Louro

2017-01-01

Full Text Available Nerve growth factor (NGF is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC degenerate following optic-nerve crush (ONC, even in the presence of increased levels of endogenous NGF. To further investigate this apparently paradoxical condition, a time-course study was performed to evaluate the effects of unilateral ONC on NGF expression and signaling in the adult retina. Visually evoked potential and immunofluorescence staining were used to assess axonal damage and RGC loss. The levels of NGF, proNGF, p75NTR, TrkA and GFAP and the activation of several intracellular pathways were analyzed at 1, 3, 7 and 14 days after crush (dac by ELISA/Western Blot and PathScan intracellular signaling array. The progressive RGC loss and nerve impairment featured an early and sustained activation of apoptotic pathways; and GFAP and p75NTR enhancement. In contrast, ONC-induced reduction of TrkA, and increased proNGF were observed only at 7 and 14 dac. We propose that proNGF and p75NTR contribute to exacerbate retinal degeneration by further stimulating apoptosis during the second week after injury, and thus hamper the neuroprotective effect of the endogenous NGF. These findings might aid in identifying effective treatment windows for NGF-based strategies to counteract retinal and/or optic-nerve degeneration.

Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells.

Science.gov (United States)

Mesentier-Louro, Louise A; De Nicolò, Sara; Rosso, Pamela; De Vitis, Luigi A; Castoldi, Valerio; Leocani, Letizia; Mendez-Otero, Rosalia; Santiago, Marcelo F; Tirassa, Paola; Rama, Paolo; Lambiase, Alessandro

2017-01-05

Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the presence of increased levels of endogenous NGF. To further investigate this apparently paradoxical condition, a time-course study was performed to evaluate the effects of unilateral ONC on NGF expression and signaling in the adult retina. Visually evoked potential and immunofluorescence staining were used to assess axonal damage and RGC loss. The levels of NGF, proNGF, p75 NTR , TrkA and GFAP and the activation of several intracellular pathways were analyzed at 1, 3, 7 and 14 days after crush (dac) by ELISA/Western Blot and PathScan intracellular signaling array. The progressive RGC loss and nerve impairment featured an early and sustained activation of apoptotic pathways; and GFAP and p75 NTR enhancement. In contrast, ONC-induced reduction of TrkA, and increased proNGF were observed only at 7 and 14 dac. We propose that proNGF and p75 NTR contribute to exacerbate retinal degeneration by further stimulating apoptosis during the second week after injury, and thus hamper the neuroprotective effect of the endogenous NGF. These findings might aid in identifying effective treatment windows for NGF-based strategies to counteract retinal and/or optic-nerve degeneration.

Utilization of crushed clay brick in cellular concrete production

Directory of Open Access Journals (Sweden)

Ali A. Aliabdo

2014-03-01

Full Text Available The main objective of this research program is to study the effect of using crushed clay brick as an alternative aggregate in aerated concrete. Two series of mixtures were designed to investigate the physico-mechanical properties and micro-structural analysis of autoclave aerated concrete and foamed concrete, respectively. In each series, natural sand was replaced with crushed clay brick aggregate. In both series results showed a significant reduction in unit weight, thermal conductivity and sound attenuation coefficient while porosity has increased. Improvement on compressive strength of autoclave aerated concrete was observed at a percentage of 25% and 50% replacement, while in foamed concrete compressive strength gradually decreased by increasing crushed clay brick aggregate content. A comparatively uniform distribution of pore in case of foamed concrete with natural sand was observed by scanning electron microscope, while the pores were connected mostly and irregularly for mixes containing a percentage higher than 25% clay brick aggregate.

The state of head injury biomechanics: past, present, and future part 2: physical experimentation.

Science.gov (United States)

Goldsmith, Werner; Monson, Kenneth L

2005-01-01

This presentation is the continuation of the article published in Critical Reviews of Biomedical Engineering, 29(5-6), 2001. That issue contained topics dealing with components and geometry of the human head, classification of head injuries, some early experimental studies, and tolerance considerations. It then dealt with head motion and load characterization, investigations during the period from 1939 to 1966, injury causation and early modeling efforts, the 1966 Head Injury Conference and its sequels, mechanical properties of solid tissues, fluid characterization, and early investigation of the mechanical properties of cranial materials. It continued with a description of the systematic investigations of solid cranial components and structural properties since 1966, fetal cranial properties, analytical head modeling, and numerical solutions of head injury. The paper concluded with experimental dynamic loading of human living and cadaver heads, dynamic loading of surrogate heads, and head injury mechanics. This portion of the paper describes physical head injury experimentation involving animals, primarily primates, human cadavers, volunteers, and inanimate physical models. In order to address the entire domain of head injury biomechanics in the two-part survey, it was intended that this information be supplemented by discussions of head injury tolerance and criteria, automotive and sports safety considerations, and the design of protective equipment, but Professor Goldsmith passed away before these sections could be completed. It is nevertheless anticipated that this attenuated installment will provide, in conjunction with the first part of the survey, a valuable resource for students and practitioners of head injury biomechanics.

Age-Dependent Schwann Cell Phenotype Regulation Following Peripheral Nerve Injury.

Science.gov (United States)

Chen, Wayne A; Luo, T David; Barnwell, Jonathan C; Smith, Thomas L; Li, Zhongyu

2017-12-01

Schwann cells are integral to the regenerative capacity of the peripheral nervous system, which declines after adolescence. The mechanisms underlying this decline are poorly understood. This study sought to compare the protein expression of Notch, c-Jun, and Krox-20 after nerve crush injury in adolescent and young adult rats. We hypothesized that these Schwann cell myelinating regulatory factors are down-regulated after nerve injury in an age-dependent fashion. Adolescent (2 months old) and young adult (12 months old) rats (n = 48) underwent sciatic nerve crush injury. Protein expression of Notch, c-Jun, and Krox-20 was quantified by Western blot analysis at 1, 3, and 7 days post-injury. Functional recovery was assessed in a separate group of animals (n = 8) by gait analysis (sciatic functional index) and electromyography (compound motor action potential) over an 8-week post-injury period. Young adult rats demonstrated a trend of delayed onset of the dedifferentiating regulatory factors, Notch and c-Jun, corresponding to the delayed functional recovery observed in young adult rats compared to adolescent rats. Compound motor action potential area was significantly greater in adolescent rats relative to young adult rats, while amplitude and velocity trended toward statistical significance. The process of Schwann cell dedifferentiation following peripheral nerve injury shows different trends with age. These trends of delayed onset of key regulatory factors responsible for Schwann cell myelination may be one of many possible factors mediating the significant differences in functional recovery between adolescent and young adult rats following peripheral nerve injury.

Immediate emergency free anterolateral thigh flap after car-tyre friction injury: A case report with eight years follow-up

Directory of Open Access Journals (Sweden)

Abdullah Merter

2017-01-01

Full Text Available The car-tyre friction injury has differences from other injuries. The components of injury which are burn, crushing, shearing, and degloving occur. Many treatment options can be performed for coverage of wound which are Vacuum Assisted Closure system (V.A.C, skin grafting, free flaps, local flaps and cross leg flap.

The influence of heavy mineral crushing in analysis of U mobile

International Nuclear Information System (INIS)

Tatang-Suherman

2000-01-01

The aim of experiments is to find out the influence of sample crushing in analysis of U mobile it was compared between U content of crusher and uncrushed samples. The uncrushed samples including the grain size of minus 40, 60, 80 and 100 mesh, since while the uncrushed sample was minus 60, 80, 100, 120 and 150 mesh. The U analysis was done by comparing with fluorescence of standard sample using Fluorimetric determination. The result of uncrushed samples have a same concentration in all of grain fractions and the crushed samples have a higher concentration on the smallest of grain fractions. The content of U mobile from crushed sample have significant result at - 120 mesh to - 150 mesh

Rock Crushing Using Microwave Pre-Treatment

KAUST Repository

Kim, Seunghee; Santamarina, Carlos

2016-01-01

Crushing and grinding are primary contributors to a high energy demand in the mining industry, yet, both are surprisingly inefficient processes, often with efficiencies as low as 1%. We analyze size reductions during crushing and grinding operations and explore the potential of multiplying internal weaknesses in rock materials by non-mechanical means. In particular, when rock blocks (wet or even dry if polycrystalline) are exposed to microwaves, internal cracks can develop along grain boundaries via differential thermal expansion between grains and volumetric thermal expansion of water in pores. Brazilian tests conducted on granite and cement mortar specimens show that the tensile strength decreases proportional to the duration of microwave treatment. Thermal changes, excessive fluid pressure buildup and induced stresses are analyzed in the context of hydro-Thermo-mechanically coupled processes. Results confirm that both differential thermal expansion of mineral grains and volumetric thermal expansion of water can generate cracks upon microwave exposure. Optimal conditions are suggested to lower the combined consumption of electric and mechanical energy.

Rock Crushing Using Microwave Pre-Treatment

KAUST Repository

Kim, Seunghee

2016-08-11

Crushing and grinding are primary contributors to a high energy demand in the mining industry, yet, both are surprisingly inefficient processes, often with efficiencies as low as 1%. We analyze size reductions during crushing and grinding operations and explore the potential of multiplying internal weaknesses in rock materials by non-mechanical means. In particular, when rock blocks (wet or even dry if polycrystalline) are exposed to microwaves, internal cracks can develop along grain boundaries via differential thermal expansion between grains and volumetric thermal expansion of water in pores. Brazilian tests conducted on granite and cement mortar specimens show that the tensile strength decreases proportional to the duration of microwave treatment. Thermal changes, excessive fluid pressure buildup and induced stresses are analyzed in the context of hydro-Thermo-mechanically coupled processes. Results confirm that both differential thermal expansion of mineral grains and volumetric thermal expansion of water can generate cracks upon microwave exposure. Optimal conditions are suggested to lower the combined consumption of electric and mechanical energy.

Flowability in crushed sand mortar

Directory of Open Access Journals (Sweden)

Cabrera, O. A.

2010-12-01

Full Text Available The present experimental study explored the relationship between mortar flowability and the voids content in crushed sand to determine the effect of grain shape and surface texture as well as dust content on the behaviour of fresh mortar. The findings revealed a close correlation between voids content and the volume of paste needed for mortar to begin to flow as a continuous material, mortar flowability and the water content needed to attain a given flowability. The comparison of the empirical findings to the results obtained with the Larrard (1, 2 model provided further information on the effect of sand grain morphology on fresh mortars.

En el presente trabajo se plantea un estudio experimental de la fluidez de morteros basado en el contenido de vacíos de arenas machacadas, para comprender la influencia de la forma y textura superficial de los granos de arena y del contenido de polvo de las mismas sobre el estado fresco de morteros. Los resultados muestran la estrecha relación entre el contenido de vacíos entre granos y los volúmenes de pasta necesarios para iniciar el escurrimiento como un material continuo, la fluidez de los morteros, el contenido de agua para alcanzar una determinada fluidez, etc. El comportamiento evaluado se compara con resultados obtenidos aplicando el modelo de F. de Larrard (1, 2, permitiendo de este modo obtener mayor información de la influencia de la morfología de los granos de la arena sobre el estado fresco de los morteros.

Experimental Traumatic Brain Injury Induces Bone Loss in Rats.

Science.gov (United States)

Brady, Rhys D; Shultz, Sandy R; Sun, Mujun; Romano, Tania; van der Poel, Chris; Wright, David K; Wark, John D; O'Brien, Terence J; Grills, Brian L; McDonald, Stuart J

2016-12-01

Few studies have investigated the influence of traumatic brain injury (TBI) on bone homeostasis; however, pathophysiological mechanisms involved in TBI have potential to be detrimental to bone. The current study assessed the effect of experimental TBI in rats on the quantity and quality of two different weight-bearing bones, the femur and humerus. Rats were randomly assigned into either sham or lateral fluid percussion injury (FPI) groups. Open-field testing to assess locomotion was conducted at 1, 4, and 12 weeks post-injury, with the rats killed at 1 and 12 weeks post-injury. Bones were analyzed using peripheral quantitative computed tomography (pQCT), histomorphometric analysis, and three-point bending. pQCT analysis revealed that at 1 and 12 weeks post-injury, the distal metaphyseal region of femora from FPI rats had reduced cortical content (10% decrease at 1 week, 8% decrease at 12 weeks; p in trabecular bone volume ratio at 1 week post-injury and a 27% reduction at 12 weeks post-injury in FPI rats compared to sham (p in bone quantity and mechanical properties of the femoral midshaft between sham and TBI animals. There were no differences in locomotor outcomes, which suggested that post-TBI changes in bone were not attributed to immobility. Taken together, these findings indicate that this rat model of TBI was detrimental to bone and suggests a link between TBI and altered bone remodeling.

Adipose-derived mesenchymal stem cells accelerate nerve regeneration and functional recovery in a rat model of recurrent laryngeal nerve injury

Directory of Open Access Journals (Sweden)

Yun Li

2017-01-01

Full Text Available Medialization thyroplasty or injection laryngoplasty for unilateral vocal fold paralysis cannot restore mobility of the vocal fold. Recent studies have shown that transplantation of mesenchymal stem cells is effective in the repair of nerve injuries. This study investigated whether adipose-derived stem cell transplantation could repair recurrent laryngeal nerve injury. Rat models of recurrent laryngeal nerve injury were established by crushing with micro forceps. Adipose-derived mesenchymal stem cells (ADSCs; 8 × 105 or differentiated Schwann-like adipose-derived mesenchymal stem cells (dADSCs; 8 × 105 or extracellular matrix were injected at the site of injury. At 2, 4 and 6 weeks post-surgery, a higher density of myelinated nerve fiber, thicker myelin sheath, improved vocal fold movement, better recovery of nerve conduction capacity and reduced thyroarytenoid muscle atrophy were found in ADSCs and dADSCs groups compared with the extracellular matrix group. The effects were more pronounced in the ADSCs group than in the dADSCs group. These experimental results indicated that ADSCs transplantation could be an early interventional strategy to promote regeneration after recurrent laryngeal nerve injury.

[Hygienic assessment of metal-lurgical slag crushed stone for its use in road-building].

Science.gov (United States)

Tikhomirov, Iu P; Ippolitova, V P; Bezrokov, M E

2010-01-01

The increasing amount of industrial waste generates a need for its use as recycled materials. The paper presents the results of hygienic assessment of metallurgic slag crushed stone to be added to natural materials in highway building. The research program has included the measurement of content of water-soluble forms of metals, the evaluation of the acute toxicity of waste after oral administration to mice and rats, the study of the toxicity of waste by biotesting and the activity of natural radionuclides. The slag crushed stone virtually lacks water-soluble elements when it contains a high level of bulk forms of metals. According to acute toxicity for warm-blooded animals, the slag crushed stone belongs to Hazard Class IV by GOST 12.1.007-76 (low hazard substances). The biotesting on hydrocoles, the slag crushed stone is also referred to as Class IV (low hazard substances). In terms of the level of natural radionuclides, the slag crushed stone poses no hazard to the environment. The performed studies give grounds to recommend metallurgical slag crushed stone to be added to natural materials for highway building.

CRUSH1: a simplified computer program for impact analysis of radioactive material transport casks

Energy Technology Data Exchange (ETDEWEB)

Ikushima, Takeshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1996-07-01

In drop impact analyses for radioactive transport casks, it has become possible to perform them in detail by using interaction evaluation, computer programs, such as DYNA2D, DYNA3D, PISCES and HONDO. However, the considerable cost and computer time are necessitated to perform analyses by these programs. To meet the above requirements, a simplified computer program CRUSH1 has been developed. The CRUSH1 is a static calculation computer program capable of evaluating the maximum acceleration of cask bodies and the maximum deformation of shock absorbers using an Uniaxial Displacement Method (UDM). The CRUSH1 is a revised version of the CRUSH. Main revisions of the computer program are as follows; (1) not only main frame computer but also work stations (OS UNIX) and personal computer (OS Windows 3.1 or Windows NT) are available for use of the CRUSH1 and (2) input data set are revised. In the paper, brief illustration of calculation method using UDM is presented. The second section presents comparisons between UDM and the detailed method. The third section provides a use`s guide for CRUSH1. (author)

CRUSH1: a simplified computer program for impact analysis of radioactive material transport casks

International Nuclear Information System (INIS)

Ikushima, Takeshi

1996-07-01

In drop impact analyses for radioactive transport casks, it has become possible to perform them in detail by using interaction evaluation, computer programs, such as DYNA2D, DYNA3D, PISCES and HONDO. However, the considerable cost and computer time are necessitated to perform analyses by these programs. To meet the above requirements, a simplified computer program CRUSH1 has been developed. The CRUSH1 is a static calculation computer program capable of evaluating the maximum acceleration of cask bodies and the maximum deformation of shock absorbers using an Uniaxial Displacement Method (UDM). The CRUSH1 is a revised version of the CRUSH. Main revisions of the computer program are as follows; (1) not only main frame computer but also work stations (OS UNIX) and personal computer (OS Windows 3.1 or Windows NT) are available for use of the CRUSH1 and (2) input data set are revised. In the paper, brief illustration of calculation method using UDM is presented. The second section presents comparisons between UDM and the detailed method. The third section provides a use's guide for CRUSH1. (author)

Effect of Raw Crushed Garlic (Allium sativum L.) on Components of Metabolic Syndrome.

Science.gov (United States)

Choudhary, Prema Ram; Jani, Rameshchandra D; Sharma, Megh Shyam

2017-09-28

Metabolic syndrome consists of a group of risk factors characterized by abdominal obesity, hypertension, atherogenic dyslipidemia, hyperglycemia, and prothrombotic and proinflammatory conditions. Raw garlic homogenate has been reported to reduce serum lipid levels in animal model; however, no precise studies have been performed to evaluate the effect of raw crushed garlic (Allium sativum L.) on components of metabolic syndrome. Therefore, the present study was designed to investigate the effect of raw crushed garlic on components of metabolic syndrome. A total of 40 metabolic syndrome patients were randomly selected from the diabetic center of SP Medical College, Bikaner, Rajasthan, India. They underwent treatment with 100 mg/kg body weight raw crushed garlic 2 times a day with standard diet for 4 weeks; their anthropometric and serum biochemical variables were measured at both the beginning and the end of the study. Statistical analysis was performed using IBM SPSS version 20, and Student's paired "t" test was used to compare variables before and after treatment with garlic preparation. Raw crushed garlic significantly reduced components of metabolic syndrome including waist circumference (p .05) of patients with metabolic syndrome after consumption of raw crushed garlic for 4 weeks. Raw crushed garlic has beneficial effects on components of metabolic syndrome; therefore, it can be used as an accompanying remedy for prevention and treatment of patients with metabolic syndrome.

Injuries and Fatalities in Danish Commercial Fishing Fleet in 1998–2016

DEFF Research Database (Denmark)

Rasmussen, Hanna Barbara; Ahsan, Dewan

2018-01-01

and the remaining injuries resulted in sick leave of more than one day; 52.5% (n = 600) of reported injuries involved fishermen who have less than one year’s experience of employment; 29% (n = 407) of injuries took place between 12:00 and 16:00, and the second largest number of injuries, 23.3% (n = 324), took place...... between 8:00 and 12:00. The incident rate of slip/fall injuries has decreased from 10.06 per 1000 fishermen in 1998 to 3.84 in 2016. The incidence rate of injuries caused by crushing also decreased, from 9.32 accidents per 1000 fishermen in 1998 to 2.56 in 2016. Most of the injuries, 74.5% (n = 1307...

Strain-rate effect on initial crush stress of irregular honeycomb under dynamic loading and its deformation mechanism

Science.gov (United States)

Wang, Peng; Zheng, Zhijun; Liao, Shenfei; Yu, Jilin

2018-02-01

The seemingly contradictory understandings of the initial crush stress of cellular materials under dynamic loadings exist in the literature, and a comprehensive analysis of this issue is carried out with using direct information of local stress and strain. Local stress/strain calculation methods are applied to determine the initial crush stresses and the strain rates at initial crush from a cell-based finite element model of irregular honeycomb under dynamic loadings. The initial crush stress under constant-velocity compression is identical to the quasi-static one, but less than the one under direct impact, i.e. the initial crush stresses under different dynamic loadings could be very different even though there is no strain-rate effect of matrix material. A power-law relation between the initial crush stress and the strain rate is explored to describe the strain-rate effect on the initial crush stress of irregular honeycomb when the local strain rate exceeds a critical value, below which there is no strain-rate effect of irregular honeycomb. Deformation mechanisms of the initial crush behavior under dynamic loadings are also explored. The deformation modes of the initial crush region in the front of plastic compaction wave are different under different dynamic loadings.

Study on the Elasticity-Plasticity-Stickiness of the Railway Crushed Stone Ballast

Institute of Scientific and Technical Information of China (English)

Gao Liang

2004-01-01

This paper is mainly aimed at the mechanics characteristic elas of ticity-plasticitystickiness existed in the CWR (continuously welded rails) track plane of the railway crushed stone ballast. As an important mechanics parameter of the CWR track plane, the ballast resistance is mainly influenced by this mechanics characteristic. Through the systematic experimental research and the theoretical analysis, this mechanics characteristic of the ballast resistance is revealed and a reasonable theoretical model is built for it. This study set a sound foundation for further studying the CWR track deformation property. It will be beneficial to the development of high-speed railway in China.

Continuous-flow leaching studies of crushed and cored SYNROC

International Nuclear Information System (INIS)

Coles, D.G.; Bazan, F.

1982-01-01

Both crushed (150- to 300- μm) and cored (1,8- mm-diam) samples of SYNROC have been leached with single-pass continuous-flow leaching equipment. Crushed samples of cesium-hollandite were also leached in a similar experiment. Temperatures used were 25 0 and 75 0 C and leachates were 0.03 N NaHCO 3 and distilled water. Leaching rates from SYNROC-C were ranked cesium > strontium greater than or equal to calcium > barium > zirconium. A comparison of leaching rates is made between crushed SYNROC, cored SYNROC, and Pacific Northwest Laboratory 76-68 glass beads. This comparison depends on how the surface areas are determined for each sample. Based on geometric surface areas for SYNROC cores and glass beads, cesium leach rates from SYNROC compare well with both sodium and neptunium leached from the glass. The other elements leached from SYNROC are lower than sodium and neptunium leached from glass. They also vary for each element, while glass shows nearly the same leach rate for both sodium and neptunium

Continuous-flow leaching studies of crushed and cored SYNROC

International Nuclear Information System (INIS)

Coles, D.G.; Bazan, F.

1981-01-01

Both crushed (150 to 300 μm) and cored (1.8 mm diameter) samples of SYNROC have been leached with the single-pass continuous-flow leaching equipment. Crushed samples of Cs-hollandite were also leached in a similar experiment. Temperatures used were 25 and 75 0 C and leachates were 0.03 N NaHCO 3 and distilled water. Leaching rates from SYNROC C were ranked Cs > Sr greater than or equal to Ca > Ba > Zr. A comparison of leaching rates is made between crushed SYNROC, cored SYNROC, and PNL 76-68 glass beads. This comparison depends on how the surface areas are determined for each sample. Based on geometric surface areas for SYNROC cores and glass beads Cs leach rates from SYNROC compare well with both Na and Np leached from the glass. The other elements leached from SYNROC are lower than Na and Np leached from glass. They also vary for each element while glass shows nearly the same leach rate for both Na and Np

Seismic tipping analysis of a spent nuclear fuel shipping cask sitting on a crush pad

International Nuclear Information System (INIS)

Uldrich, E.D.; Hawkes, B.D.

1998-04-01

A crush pad has been designed and analyzed to absorb the kinetic energy of an accidentally dropped spent nuclear fuel shipping cask into a 44 ft. deep cask unloading pool. Conventional analysis techniques available for evaluating a cask for tipping due to lateral seismic forces assume that the cask rests on a rigid surface. In this analysis, the cask (110 tons) sits on a stainless steel encased (0.25 in. top plate), polyurethane foam (4 ft. thick) crush pad. As the cask tends to rock due to horizontal seismic forces, the contact area between the cask and the crush pad is reduced, increasing the bearing stress, and causing the pivoting corner of the cask to depress into the crush pad. As the crush pad depresses under the cask corner, the pivot point shifts from the corner toward the cask center, which facilitates rocking and potential tipping of the cask. Subsequent rocking of the cask may deepen the depression, further contributing to the likelihood of cask tip over. However, as the depression is created, the crush pad is absorbing energy from the rocking cask. Potential tip over of the cask was evaluated by performing a non-linear, dynamic, finite element analysis with acceleration time history input. This time history analysis captured the effect of a deforming crush pad, and also eliminated conservatisms of the conventional approaches. For comparison purposes, this analysis was also performed with the cask sitting on a solid stainless steel crush pad. Results indicate that the conventional methods are quite conservative relative to the more exacting time history analysis. They also indicate that the rocking motion is less on the foam crush pad than on the solid stainless steel pad

Calculation of density and permeability of compacted crushed salt within an engineered shaft sealing system

International Nuclear Information System (INIS)

Loken, M.; Statham, W.

1997-01-01

Crushed salt from the host Salado Formation is proposed as a sealing material in one component of a multicomponent seal system design for the shafts of the Waste Isolation Pilot Plant (WIPP), a mined geological repository for storage and disposal of transuranic radioactive wastes located near Carlsbad, New Mexico. The crushed salt will be compacted and placed at a density approaching 90% of the intact density of the host Salado salt. Creep closure of the shaft will further compact the crushed salt over time, thereby reducing the crushed-salt permeability from the initial state and creating an effective long-term seal. A structural model and a fluid flow model have been developed to provide an estimate of crushed-salt reconsolidation rate as a function of depth, time, and pore pressure. Model results are obtained in terms of crushed-salt permeability as a function of time and depth within the salt column. Model results indicate that average salt column permeability will be reduced to 3.3 x 10 -20 m 2 in about 100 years, which provides for an acceptable long-term seal component

A standardized method to create peripheral nerve injury in dogs using an automatic non-serrated forceps

Institute of Scientific and Technical Information of China (English)

Xuhui Wang; Shiting Li; Liang Wan; Xinyuan Li; Youqiang Meng; Ningxi Zhu; Min Yang; Baohui Feng; Wenchuan Zhang; Shugan Zhu

2012-01-01

This study describes a method that not only generates an automatic and standardized crush injury in the skull base, but also provides investigators with the option to choose from a range of varying pressure levels. We designed an automatic, non-serrated forceps that exerts a varying force of 0 to 100 g and lasts for a defined period of 0 to 60 seconds. This device was then used to generate a crush injury to the right oculomotor nerve of dogs with a force of 10 g for 15 seconds, resulting in a deficit in the pupil-light reflex and ptosis. Further testing of our model with Toluidine-blue staining demonstrated that, at 2 weeks post-surgery disordered oculomotor nerve fibers, axonal loss, and a thinner than normal myelin sheath were visible. Electrophysiological examination showed occasional spontaneous potentials. Together, these data verified that the model for oculomotor nerve injury was successful, and that the forceps we designed can be used to establish standard mechanical injury models of peripheral nerves.

Research of environmentally-friendly utilization methods of the crushed stone waste on granite quarries

Directory of Open Access Journals (Sweden)

Levytskyi V.G.

2017-12-01

Full Text Available The analysis of activity of stone-mining enterprises shows the low competitiveness of crushed stone products Upgrading the quality of crushed stone and production of the European standard fractions requires to use of new technologies and equipment. The main waste of crushed stone pits is сrushed granite waste, which high percent of an exit is caused by outdated equipment and incorrectly selected technological parameters of the crushing process. Crushed-granite waste is stored in dumps which occupy large areas and negatively effect on production area ecology. In November 2017, the Government of Ukraine accepted the National Waste Management Strategy until 2030, the main aim of it is develop a strategy of the mineral raw materials balanced use and international standards introduction at the national level. Therefore, the problem of complex utilization and recycling of waste from stone-mining enterprises with receiving a qualitative secondary product is relevant. The publication presents the сrushed granite waste volumes by crushed stone pit, its properties and main directions of utilization. The ecological influence of waste dumps, in particular granite dust, on the environment and human, the strategy of using non-waste technologies and ecological features of сrushed granite waste secondary processing are considered

Expression patterns and role of PTEN in rat peripheral nerve development and injury.

Science.gov (United States)

Chen, Hui; Xiang, Jianping; Wu, Junxia; He, Bo; Lin, Tao; Zhu, Qingtang; Liu, Xiaolin; Zheng, Canbin

2018-05-29

Studies have suggested that phosphatase and tensin homolog (PTEN) plays an important role in neuroprotection and neuronal regeneration. To better understand the potential role of PTEN with respect to peripheral nerve development and injury, we investigated the expression pattern of PTEN at different stages of rat peripheral nerve development and injury and subsequently assessed the effect of pharmacological inhibition of PTEN using bpV(pic) on axonal regeneration in a rat sciatic nerve crush injury model. During the early stages of development, PTEN exhibits low expression in neuronal cell bodies and axons. From embryonic day (E) 18.5 and postnatal day (P)5 to adult, PTEN protein becomes more detectable, with high expression in the dorsal root ganglia (DRG) and axons. PTEN expression is inhibited in peripheral nerves, preceding myelination during neuronal development and remyelination after acute nerve injury. Low PTEN expression after nerve injury promotes Akt/mammalian target of rapamycin (mTOR) signaling pathway activity. In vivo pharmacological inhibition of PTEN using bpV(pic) promoted axonal regrowth, increased the number of myelinated nerve fibers, improved locomotive recovery and enhanced the amplitude response and nerve conduction velocity following stimulation in a rat sciatic nerve crush injury model. Thus, we suggest that PTEN may play potential roles in peripheral nerve development and regeneration and that inhibition of PTEN expression is beneficial for nerve regeneration and functional recovery after peripheral nerve injury. Copyright © 2018 Elsevier B.V. All rights reserved.

Study on characteristics of printed circuit board liberation and its crushed products.

Science.gov (United States)

Quan, Cui; Li, Aimin; Gao, Ningbo

2012-11-01

Recycling printed circuit board waste (PCBW) waste is a hot issue of environmental protection and resource recycling. Mechanical and thermo-chemical methods are two traditional recycling processes for PCBW. In the present research, a two-step crushing process combined with a coarse-crushing step and a fine-pulverizing step was adopted, and then the crushed products were classified into seven different fractions with a standard sieve. The liberation situation and particle shape in different size fractions were observed. Properties of different size fractions, such as heating value, thermogravimetric, proximate, ultimate and chemical analysis were determined. The Rosin-Rammler model was applied to analyze the particle size distribution of crushed material. The results indicated that complete liberation of metals from the PCBW was achieved at a size less than 0.59 mm, but the nonmetal particle in the smaller-than-0.15 mm fraction is liable to aggregate. Copper was the most prominent metal in PCBW and mainly enriched in the 0.42-0.25 mm particle size. The Rosin-Rammler equation adequately fit particle size distribution data of crushed PCBW with a correlation coefficient of 0.9810. The results of heating value and proximate analysis revealed that the PCBW had a low heating value and high ash content. The combustion and pyrolysis process of PCBW was different and there was an obvious oxidation peak of Cu in combustion runs.

Immediate emergency free anterolateral thigh flap after car-tyre friction injury: A case report with eight years follow-up.

Science.gov (United States)

Merter, Abdullah; Armangil, Mehmet; Kaya, Burak; Bilgin, Sinan

2017-01-01

The car-tyre friction injury has differences from other injuries. The components of injury which are burn, crushing, shearing, and degloving occur. Many treatment options can be performed for coverage of wound which are Vacuum Assisted Closure system (V.A.C), skin grafting, free flaps, local flaps and cross leg flap. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Cask crush pad analysis using detailed and simplified analysis methods

International Nuclear Information System (INIS)

Uldrich, E.D.; Hawkes, B.D.

1997-01-01

A crush pad has been designed and analyzed to absorb the kinetic energy of a hypothetically dropped spent nuclear fuel shipping cask into a 44-ft. deep cask unloading pool at the Fluorinel and Storage Facility (FAST). This facility, located at the Idaho Chemical Processing Plant (ICPP) at the Idaho national Engineering and Environmental Laboratory (INEEL), is a US Department of Energy site. The basis for this study is an analysis by Uldrich and Hawkes. The purpose of this analysis was to evaluate various hypothetical cask drop orientations to ensure that the crush pad design was adequate and the cask deceleration at impact was less than 100 g. It is demonstrated herein that a large spent fuel shipping cask, when dropped onto a foam crush pad, can be analyzed by either hand methods or by sophisticated dynamic finite element analysis using computer codes such as ABAQUS. Results from the two methods are compared to evaluate accuracy of the simplified hand analysis approach

Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration

Directory of Open Access Journals (Sweden)

Guang-bin Zha

2016-01-01

Full Text Available Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated, whether tau is involved in peripheral nerve regeneration remains unknown. In the current study, we obtained sciatic nerve tissue from adult rats 0, 1, 4, 7, and 14 days after sciatic nerve crush and examined tau mRNA and protein expression levels and the location of tau in the sciatic nerve following peripheral nerve injury. The results from our quantitative reverse transcription polymerase chain reaction analysis showed that compared with the uninjured control sciatic nerve, mRNA expression levels for both tau and tau tubulin kinase 1, a serine/threonine kinase that regulates tau phosphorylation, were decreased following peripheral nerve injury. Our western blot assay results suggested that the protein expression levels of tau and phosphorylated tau initially decreased 1 day post nerve injury but then gradually increased. The results of our immunohistochemical labeling showed that the location of tau protein was not altered by nerve injury. Thus, these results showed that the expression of tau was changed following sciatic nerve crush, suggesting that tau may be involved in peripheral nerve repair and regeneration.

Axial Crush of the Tubular Structure with Various Cee-Shaped Cross-Sections

International Nuclear Information System (INIS)

Afshar, Reza; Ali, Aidy; Sahari, B B; Bayat, M

2011-01-01

Tubular structure with various Cee-shaped cross sections is numerically investigated in order to find the centre of gravity (COG) under axial crush by using program code of ANSYS/LS-DYNA. A subroutine is developed using this code to obtain the COG of deformed shape, during and after crush deformation. The effect of wall thickness of the structure on displacement of COG is also studied. Subsequently, the effect of opening angle of Cee become more prominent as the wall thickness of the structure decreases and as the thickness increases, displacement of the COG in crush direction almost stabilizes for all opening angle of Cee in the range of (10 0 - 90 0 ). Furthermore, Variation of I yy of structure with thicker wall for different cases of applied weight is approximately identical. The value of mass moment of inertia with respect to X and Z axes through the model COG (I zx ) in comparison with I yy can be neglected in the case of axial crush along Y direction.

Shape Effect of Crushed Sand Filler on Rheology: A Preliminary Experimental and Numerical Study

DEFF Research Database (Denmark)

Spangenberg, Jon; Cepuritis, Rolands; Hovad, Emil

2016-01-01

Two types of filler from crushed sand were mixed with cement paste with constant superplasticizer dosage per mass of cement to investigate how their shape affects the rheology. The fillers were mylonitic quartz diorite and limestone produced using Vertical Shaft Impact (VSI) crusher and air...... was quantified with the slump flow test (i.e. mini cone). The shape effect was isolated in the experiments by the use of non overlapping bimodal particle distributions of cement particles with a number average diameter of approximate to 0.01 mm and filler particles with a number average diameter of approximate...... to 0.1 mm. The two filler types were tested with a range of chi-values (volume of cement divided by total volume of solids). The flowability of the matrix increased with decreasing aspect ratios of the filler. However, the chi-value at which the maximum volume fraction threshold was obtained varied...

Evaluation of potential crushed-salt constitutive models

International Nuclear Information System (INIS)

Callahan, G.D.; Loken, M.C.; Sambeek, L.L. Van; Chen, R.; Pfeifle, T.W.; Nieland, J.D.; Hansen, F.D.

1995-12-01

Constitutive models describing the deformation of crushed salt are presented in this report. Ten constitutive models with potential to describe the phenomenological and micromechanical processes for crushed salt were selected from a literature search. Three of these ten constitutive models, termed Sjaardema-Krieg, Zeuch, and Spiers models, were adopted as candidate constitutive models. The candidate constitutive models were generalized in a consistent manner to three-dimensional states of stress and modified to include the effects of temperature, grain size, and moisture content. A database including hydrostatic consolidation and shear consolidation tests conducted on Waste Isolation Pilot Plant and southeastern New Mexico salt was used to determine material parameters for the candidate constitutive models. Nonlinear least-squares model fitting to data from the hydrostatic consolidation tests, the shear consolidation tests, and a combination of the shear and hydrostatic tests produces three sets of material parameter values for the candidate models. The change in material parameter values from test group to test group indicates the empirical nature of the models. To evaluate the predictive capability of the candidate models, each parameter value set was used to predict each of the tests in the database. Based on the fitting statistics and the ability of the models to predict the test data, the Spiers model appeared to perform slightly better than the other two candidate models. The work reported here is a first-of-its kind evaluation of constitutive models for reconsolidation of crushed salt. Questions remain to be answered. Deficiencies in models and databases are identified and recommendations for future work are made. 85 refs

Testing and injury potential analysis of rollovers with narrow object impacts.

Science.gov (United States)

Meyer, Steven E; Forrest, Stephen; Herbst, Brian; Hayden, Joshua; Orton, Tia; Sances, Anthony; Kumaresan, Srirangam

2004-01-01

Recent statistics highlight the significant risk of serious and fatal injuries to occupants involved in rollover collisions due to excessive roof crush. The government has reported that in 2002. Sports Utility Vehicle rollover related fatalities increased by 14% to more than 2400 annually. 61% of all SUV fatalities included rollovers [1]. Rollover crashes rely primarily upon the roof structures to maintain occupant survival space. Frequently these crashes occur off the travel lanes of the roadway and, therefore, can include impacts with various types of narrow objects such as light poles, utility poles and/or trees. A test device and methodology is presented which facilitates dynamic, repeatable rollover impact evaluation of complete vehicle roof structures with such narrow objects. These tests allow for the incorporation of Anthropomorphic Test Dummies (ATDs) which can be instrumented to measure accelerations, forces and moments to evaluate injury potential. High-speed video permits for detailed analysis of occupant kinematics and evaluation of injury causation. Criteria such as restraint performance, injury potential, survival space and the effect of roof crush associated with various types of design alternatives, countermeasures and impact circumstances can also be evaluated. In addition to presentation of the methodology, two representative vehicle crash tests are also reported. Results indicated that the reinforced roof structure significantly reduced the roof deformation compared to the production roof structure.

Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healing-associated genes

Directory of Open Access Journals (Sweden)

Matt C Danzi

2016-01-01

Full Text Available Animal models of sciatic nerve injury are commonly used to study neuropathic pain as well as axon regeneration. Administration of post-surgical analgesics is an important consideration for animal welfare, but the actions of the analgesic must not interfere with the scientific goals of the experiment. In this study, we show that treatment with either buprenorphine or acetaminophen following a bilateral sciatic nerve crush surgery does not alter the expression in dorsal root ganglion (DRG sensory neurons of a panel of genes associated with wound healing. These findings indicate that the post-operative use of buprenorphine or acetaminophen at doses commonly suggested by Institutional Animal Care and Use Committees does not change the intrinsic gene expression response of DRG neurons to a sciatic nerve crush injury, for many wound healing-associated genes. Therefore, administration of post-operative analgesics may not confound the results of transcriptomic studies employing this injury model.

Analysis of the engine fragment threat and the crush environment for small packages carried on U.S. commercial jet aircraft

International Nuclear Information System (INIS)

Hartman, W.F.; McClure, J.D.; von Riesemann, W.A.

1978-01-01

The results of two separate analyses are reported. The engine fragment analysis determined the probability of a small package being in the path of a fragment from a failure in a gas turbine engine. The calculated values show that, depending on aircraft type, the incidence rate varies by approximately an order of magnitude from a high of about once per 5 million flights to a low of nearly once every 40 million package flights for a flight of five hours' duration. The analysis of the crush environment consisted of an examination of two principal crush modes, i.e., vertical and longitudinal crush. The vertical crush mode was examined by formulating a structural model of the cargo deck beams of the aircraft. The longitudinal crush mode was studied by using dynamic models of the aircraft cargo and the radioactive material package (RAM). The results of the analysis of these crush modes provided the basis for the formulation of a 310 kN/(70,000 lb) crush test to simulate vertical crush. The longitudinal crush analysis indicated that it was possible, under infrequently occurring conditions, to produce extremely large crush forces and hence it was recommended that RAM packages be located in the aft end of aircraft cargo compartments to minimize the effects of longitudinal crush

Analysis of a hypothetical dropped spent nuclear fuel shipping cask impacting a floor mounted crush pad

International Nuclear Information System (INIS)

Hawkes, B.D.; Uldrich, E.D.

1998-03-01

A crush pad has been designed and analyzed to absorb the kinetic energy of a hypothetically dropped spent nuclear fuel shipping cask into a 44-ft. deep cask unloading pool at the Idaho Chemical Processing Plant. The 110-ton Large Cell Cask was assumed to be accidentally dropped onto the parapet of the unloading pool, causing the cask to tumble through the pool water and impact the floor mounted crush pad with the cask's top corner. The crush pad contains rigid polyurethane foam, which was modeled in a separate computer analysis to simulate the manufacturer's testing of the foam and to determine the foam's stress and strain characteristics. This computer analysis verified that the foam was accurately represented in the analysis to follow. A detailed non-linear, dynamic finite element analysis was then performed on the crush pad and adjacent pool structure to assure that a drop of this massive cask does not result in unacceptable damage to the storage facility. Additionally, verification was made that the crush pad adequately protects the cask from severe impact loading. At impact, the cask has significant vertical, horizontal and rotational velocities. The crush pad absorbs much of the energy of the cask through plastic deformation during primary and secondary impacts. After the primary impact with the crush pad, the cask still has sufficient energy to rebound and rotate until it impacts the pool wall. An assessment is made of the damage to the crush pad and pool wall and of the impact loading on the cask

Effect of crushing temperature on virgin olive oil quality and composition

OpenAIRE

Ö. Kula; A. Yıldırım; A. Yorulmaz; M. Duran; İ. Mutlu; M. Kıvrak

2018-01-01

The objective of the current study was to assess the influence of a modified crushing process and kneading operation on the quality parameters, volatile compounds, and the fatty acid and sterol profiles of virgin olive oil from the Edremit yaglik variety. In the study, olive oil samples were produced in two different processes. The first one was produced without malaxation and the second one was produced with the malaxing process. During crushing, the effect of different temperatures was test...

Application of vacuum metallurgy to separate pure metal from mixed metallic particles of crushed waste printed circuit board scraps.

Science.gov (United States)

Zhan, Lu; Xu, Zhenming

2008-10-15

The principle of separating pure metal from mixed metallic particles (MMPs) byvacuum metallurgy is that the vapor pressures of various metals at the same temperature are different As a result, the metal with high vapor pressure and low boiling point can be separated from the mixed metals through distillation or sublimation, and then it can be recycled through condensation under a certain condition. The vacuum metallurgy separation (VMS) of MMPs of crushed waste printed circuit boards (WPCBs) has been studied in this paper. Theoretical analyses show that the MMPs (copper, zinc, bismuth, lead, and indium, for example) can be separated by vacuum metallurgy. The copper particles (0.15-0.20 mm) and zinc particles (<0.30 mm) were chosen to simulate the MMPs of crushed WPCBs. Experimental results show that the separated efficiency of zinc in the copper-rich particles achieves 96.19 wt % when the vacuum pressure is 0.01-0.10 Pa, the heating temperature is 1123 K, and the heating time is 105 min. Under this operation condition, the separated efficiency of zinc in the copper-rich particles from crushed WPCBs achieves 97.00 wt % and the copper purity increases from 90.68 to 99.84 wt %.

Evaluation of crushed aggregate and sand-bentonite mixtures for application to sealing of the final repository for reactor waste

International Nuclear Information System (INIS)

Vaajasaari, M.; Saari, K.; Wang Zhen

1986-09-01

The Industrial Power Company Ltd (TVO) is planning to dispose the low- and intermediate level waste from the reactors of the Olkiluoto Nuclear Power Station into the bedrock of Olkiluoto at a depth of approximately 50-100 meters. In the TVO concept the reactor waste is disposed in silo shaped rock caverns. The bituminized waste is packed into steel drums, which are laid into a concrete silo inside the rock cavern. In this study the properties of sands, crushed aggregate and their mixtures with bentonite are reviewed. The applicability of these materials for use as a buffer on the top of the concrete silo is evaluated. This study is based on earlier experimental studies of the materials mentioned before and available literature. Gas production in the silo after disposal is estimated. General concepts of gas conductivity and gas migration in saturated soil are reviewed. The results of this study suggest that crushed aggregate and sand-bentonite mixtures are possible sealing materials for the silo in concern. But the need for further experimental study of their physical and mechanical properties and the gas migration processes through the saturated barrier is emphasized. A program for testing of these properties is presented

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

KAUST Repository

Morrison, Brett M.; Tsingalia, Akivaga; Vidensky, Svetlana; Lee, Youngjin; Jin, Lin; Farah, Mohamed H.; Lengacher, Sylvain; Magistretti, Pierre J.; Pellerin, Luc; Rothsteinb, Jeffrey D.

2015-01-01

Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplying lactate or other energy metabolites to axons. In the current study, MCT1 is shown to localize within the peripheral nervous system to perineurial cells, dorsal root ganglion neurons, and Schwann cells by MCT1 immunofluorescence in wild-type mice and tdTomato fluorescence in MCT1 BAC reporter mice. To investigate whether MCT1 is necessary for peripheral nerve regeneration, sciatic nerves of MCT1 heterozygous mice are crushed and peripheral nerve regeneration was quantified electrophysiologically and anatomically. Compound muscle action potential (CMAP) recovery is delayed from a median of 21. days in wild-type mice to greater than 38. days in MCT1 heterozygote mice. In fact, half of the MCT1 heterozygote mice have no recovery of CMAP at 42. days, while all of the wild-type mice recovered. In addition, muscle fibers remain 40% more atrophic and neuromuscular junctions 40% more denervated at 42. days post-crush in the MCT1 heterozygote mice than wild-type mice. The delay in nerve regeneration is not only in motor axons, as the number of regenerated axons in the sural sensory nerve of MCT1 heterozygote mice at 4. weeks and tibial mixed sensory and motor nerve at 3. weeks is also significantly reduced compared to wild-type mice. This delay in regeneration may be partly due to failed Schwann cell function, as there is reduced early phagocytosis of myelin debris and remyelination of axon segments. These data for the first time demonstrate that MCT1 is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush.

Nutritional parameters of steers receiving different levels of sunflower crushed in partial replacement of soybean meal.

Science.gov (United States)

Lima, Hellen L; Goes, Rafael H T B de; Cerilo, Sara L N; Oliveira, Euclides R de; Gressler, Maria G M; Brabes, Kelly C S

2013-01-01

To evaluate of the sunflower crushed in nutritional parameters in steers, supplemented at pasture, we used four steers in 4×4 Latin square design. The supplements were provided in 6 g/kg of body weight/animal/day, consisting of sunflower crushed, corn, soybean meal and mineral. All the supplements was isonitrogenous and soybean meal was replaced in 0, 20, 40, and 60% for sunflower crushed. The determination of ruminal pH and ammonia was at 0, 2, 4, 6 and 8 h. after feeding and for short-chain fatty acids it was collected at 0 and 6 h. post-feeding. The dry matter intake was not affected (P>0.05) by inclusion of sunflower crushed (mean=6.59 kg/day). There was no significant effect (P>0.05) for pH for the inclusion of sunflower crushed (mean=6.41). For contents of ruminal NH₃-N was a significant effect (P replacement of soybean meal did not alter nutrition parameters.

Establishment of a head injury by club model in rabbits and experimental conditions

International Nuclear Information System (INIS)

Cao Yunxing; Xi Huanjiu; Zhang Jing; Li Hongwei; Yin Zhiyong; Zhao Hui

2013-01-01

Objective: To establish an animal model to replicate the injury by club in forensic medicine. Methods: Twenty-four New Zealand white rabbits were divided into control group (n=4), minor injury group (n=10), and severe injury group (n=10). Based on the BIM-Ⅱ Horizontal Bio-impact Machine, a self-designed iron bar was used to produce head injury by club. Six hours after injury, all the rabbits were subjected to a CT examination and dissected to observe the injury morphology and undergo routine pathological examination. Four control, six minor and severe rabbits were given moisture content examination. Results: Varying degrees of positive signs of the nervous system were observed in all the injured rabbits within 6 hours. The mortality rate was 1/10 in the minor injury group and 6/10 in the severe injury group. The morphological changes consisted of different levels of scalp hematoma, skull fracture, epidural hematoma, subdural hematoma, subarachnoid hemorrhage and brain injury. The difference in moisture content between the three groups was of statistical significance. Conclusion: Under the rigidly-controlled experimental condition, this animal model produces good reproducibility and stable results. Meanwhile, it can simulate the morphology of injury by club and be used to study the mechanism of injury by club in forensic medicine. (authors)

Flow-controlled expiration: a novel ventilation mode to attenuate experimental porcine lung injury.

Science.gov (United States)

Goebel, U; Haberstroh, J; Foerster, K; Dassow, C; Priebe, H-J; Guttmann, J; Schumann, S

2014-09-01

Whereas the effects of various inspiratory ventilatory modifications in lung injury have extensively been studied, those of expiratory ventilatory modifications are less well known. We hypothesized that the newly developed flow-controlled expiration (FLEX) mode provides a means of attenuating experimental lung injury. Experimental acute respiratory distress syndrome was induced by i.v. injection of oleic acid in 15 anaesthetized and mechanically ventilated pigs. After established lung injury ([Formula: see text]ratio ventilation (VCV) or a treatment group receiving VCV with additional FLEX (VCV+FLEX). At predefined times, lung mechanics and oxygenation were assessed. At the end of the experiment, the pigs were killed, and bronchoalveolar fluid and lung biopsies were taken. Expression of inflammatory cytokines was analysed in lung tissue and bronchoalveolar fluid. Lung injury score was determined on the basis of stained tissue samples. Compared with the control group (VCV; n=8), the VCV+FLEX group (n=7) demonstrated greater dynamic lung compliance and required less PEEP at comparable [Formula: see text] (both Pprotective ventilation. © The Author [2014]. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Magnetic resonance imaging of experimental spinal cord injury

International Nuclear Information System (INIS)

Nakamura, Tsutomu; Kumano, Kouichi; Kadoya, Satoru

1989-01-01

Correlation between pathological findings and magnetic resonance imaging (MRI) of experimental cord injury were investigated. Cord injuries were made on ten Wistar rats weighing 80-170 gm by epidural compression of the thoracic cord with a Biemer cerebral vascular clip for 5-20 seconds. Several hours after the procedure animals were examined by spin echo axial MR images with a pulse sequence of TR/TE=1000/36 msec. MR studies were repeated on 4 animals 3-7 days after the initial examination. Immediately after the latest MRI examination animals were sacrificed and fixed with 10% formalin. Three micron thickness paraffin sections stained with hematoxylin and eosin were evaluated under a microscope. The pathological finding was hemorrhagic necrosis with edema of various severity depending on duration of clip application. The hemorrhagic necrosis was observed either unilaterally or bilaterally to the cord. MR findings of the cord were of high intensity in five animals which were severely injured, while central low intensity of the injured cord appeared in three mildly injured animals. Of the remaining two animals which had mild injury, one showed unilateral high intensity, while no definitive change was demonstrated in the other. The high intensity in the MRI suggested edema associated with hemorrhagic necrosis rather than hemorrhage. The central low intensity appearing in the mildly injured cord might be hemorrhage in the gray matter. It is concluded that MRI was useful to diagnose not only the level and severity but also the pathological process in the injured cord, and thus to estimate the prognosis of the cord injuries. (author)

Sandvik sharpens in-pit crushing focus

Energy Technology Data Exchange (ETDEWEB)

Casteel, K.

2009-04-15

Major mining equipment supplier Sandvik Mining and Construction has announced a full-fledged fully mobile crushing plant, the PF300. This is shaping up to be the decade's major addition to the large scale open-cut mining toolkit. The PF300 can be connected to a face conveyor by a loading bridge as well as by belt wagon or transfer conveyor. The article describes design features. 2 figs.

Simulation and modeling of the crushing behavior of structural members

International Nuclear Information System (INIS)

Toi, Yutaka

1986-01-01

The analysis of the crushing behavior (the behavior of compressive breakdown accompanied by super large deformation) of structural members is an important subject which becomes the base of the ultimate strength design of the structures which may cause collision accident such as automobiles, ships and aircrafts, and of those which are feared to be collided such as offshore structures, bridge piers and nuclear power plants. However, since it is a phenomenon of very strong nonlinearity, its analysis is accompanied by large difficulty. In this report, three kinds of the approach for this problem, that is, rigid-plastic theoretical analysis, the simulation using a rigid body and spring model and nonlinear finite element analysis, are explained, referring to the example of calculation by the authors on the non-axisymmetric crushing problem of cylindrical shells. In crushing problem, the matters of concern are the amount of collision energy which can be absorbed by the plastic deformation of structures and the amount of deformation. It can be said that the increase of calculation cost brings about the heightening of calculation accuracy. The nonlinear finite element analysis is promising because its calculation cost is expected to lower in future. (Kako, I.)

Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats

Directory of Open Access Journals (Sweden)

Olavo Biraghi Letaif

2015-10-01

Full Text Available OBJECTIVES:To evaluate the functional and histological effects of estrogen as a neuroprotective agent after a standard experimentally induced spinal cord lesion.METHODS:In this experimental study, 20 male Wistar rats were divided into two groups: one group with rats undergoing spinal cord injury (SCI at T10 and receiving estrogen therapy with 17-beta estradiol (4mg/kg immediately following the injury and after the placement of skin sutures and a control group with rats only subjected to SCI. A moderate standard experimentally induced SCI was produced using a computerized device that dropped a weight on the rat's spine from a height of 12.5 mm. Functional recovery was verified with the Basso, Beattie and Bresnahan scale on the 2nd, 7th, 14th, 21st, 28th, 35th and 42nd days after injury and by quantifying the motor-evoked potential on the 42nd day after injury. Histopathological evaluation of the SCI area was performed after euthanasia on the 42nd day.RESULTS:The experimental group showed a significantly greater functional improvement from the 28th to the 42nd day of observation compared to the control group. The experimental group showed statistically significant improvements in the motor-evoked potential compared with the control group. The results of pathological histomorphometry evaluations showed a better neurological recovery in the experimental group, with respect to the proportion and diameter of the quantified nerve fibers.CONCLUSIONS:Estrogen administration provided benefits in neurological and functional motor recovery in rats with SCI beginning at the 28th day after injury.

Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats.

Science.gov (United States)

Letaif, Olavo Biraghi; Cristante, Alexandre Fogaça; Barros Filho, Tarcísio Eloy Pessoa de; Ferreira, Ricardo; Santos, Gustavo Bispo dos; Rocha, Ivan Dias da; Marcon, Raphael Martus

2015-10-01

To evaluate the functional and histological effects of estrogen as a neuroprotective agent after a standard experimentally induced spinal cord lesion. In this experimental study, 20 male Wistar rats were divided into two groups: one group with rats undergoing spinal cord injury (SCI) at T10 and receiving estrogen therapy with 17-beta estradiol (4mg/kg) immediately following the injury and after the placement of skin sutures and a control group with rats only subjected to SCI. A moderate standard experimentally induced SCI was produced using a computerized device that dropped a weight on the rat's spine from a height of 12.5 mm. Functional recovery was verified with the Basso, Beattie and Bresnahan scale on the 2nd, 7th, 14th, 21st, 28th, 35th and 42nd days after injury and by quantifying the motor-evoked potential on the 42nd day after injury. Histopathological evaluation of the SCI area was performed after euthanasia on the 42nd day. The experimental group showed a significantly greater functional improvement from the 28th to the 42nd day of observation compared to the control group. The experimental group showed statistically significant improvements in the motor-evoked potential compared with the control group. The results of pathological histomorphometry evaluations showed a better neurological recovery in the experimental group, with respect to the proportion and diameter of the quantified nerve fibers. Estrogen administration provided benefits in neurological and functional motor recovery in rats with SCI beginning at the 28th day after injury.

Effects of crushed conspecifics on growth and survival of Penaeus monodon Fabricius post larvae

NARCIS (Netherlands)

Nga, B.T.; Lürling, M.F.L.L.W.; Peeters, E.T.H.M.; Roijackers, R.M.M.; Scheffer, M.; Nghia, T.T.

2006-01-01

In the present study, the hypothesis tested was that Penaeus monodon post-larvae (PL) experience lower growth when exposed to crushed conspecifics, which was achieved by exposing individual P. monodon PL with abundant food for 4 weeks to a gradient from 0 to 100 crushed conspecific PL L1. Both dry

Application of Crushed Concrete in Geotechnical Engineering - Selected Issues

Science.gov (United States)

Kawalec, Jacek; Kwiecien, Slawomir; Pilipenko, Anton; Rybak, Jarosław

2017-12-01

The reuse of building materials becomes an important issue in sustainable engineering. As the technical requirements for civil engineering structures changes with time and the life time is limited, the need of building new objects meets the necessity of recycling of the existing ones. In the case of steel structures, the possibility of recycling is obvious, also in the case of wooden constructions, the possibility of “burning” solves the problem. The concrete waste is generated mainly as a result of the demolition and reconstruction of residential and industrial buildings. These types of waste are basically made from crushed rocks and cement minerals and contain non-hydrated cement particles in its composition. Concrete poses a lot of problems mainly for two reasons. It is difficult to crush, heavy and hard to transport and demanding in reuse. Different fractions (particle sizes) may be used for different purposes. Starting from very fine particles which can be used in concrete production, through regular 16-300 mm fractions used to form new fills and fill the mats, up to very irregular mixtures used to form stone columns by means of Impulse Compaction or in Dynamic Replacement. The presented study juxtaposes authors experience with crushed concrete used in civil engineering, mainly in geotechnical projects. Authors’ experiences comprise the application of crushed concrete in the new concrete production in Russia, changing pulverized bridge into the fill of mesh sacks, or mattresses used as an effective way to protect the shoreline and the New Orleans East land bridge after Katrina storm (forming a new shoreline better able to withstand wave actions), and finally the use of very irregular concrete fractions to form stone columns in week soils on the example of railway and road projects in Poland. Selected case studies are presented and summarized with regard to social, technical and economic issues including energy consumption needed for proposed technologies

Role of Water Sorption in Tablet Crushing Strength, Disintegration, and Dissolution.

Science.gov (United States)

Sacchetti, M; Teerakapibal, R; Kim, K; Elder, E J

2017-08-01

Drugs formulated as tablets are subjected to accelerated stability conditions with the goal of identifying a stable formulation that will exhibit a sufficiently long shelf life. Water sorption at a condition such as 40°C/75% RH can result in significant changes in tablet properties such as a decrease in dissolution rate, the cause of which may be difficult to interpret, given the complex nature of ingredients and their interactions in a tablet. In this research, three drugs, displaying a wide range of physicochemical properties, were formulated with commonly used diluents, disintegrants, and binders, using a design of experiments approach. The tablets were stored at accelerated conditions and assessed for content, dissolution, disintegration, and crushing strength, as well as other properties. The research demonstrated many water-induced effects in tablet properties. Due to the experimental design approach that revealed many interactions, it was possible to interpret all of the changes observed in tablet crushing strength, disintegration, and dissolution for the drugs using a common set of physical principles. Specifically, the relevant factors considered were (1) mechanical properties of materials, (2) water sorption surface effects in surface diffusion and capillary condensation, (3) water sorption bulk effects for amorphous materials such as viscous flow/spreading, and (4) water-induced stress on interparticle bonding arising from volume expansion. These physical principles enable a comprehensive interpretation of the complex changes observed in tablet properties, which should be valuable in the design of tablet formulations that will be stable to accelerated storage conditions.

Crushed tablets: does the administration of food vehicles and thickened fluids to aid medication swallowing alter drug release?

Science.gov (United States)

Manrique, Yady J; Lee, Danielle J; Islam, Faiza; Nissen, Lisa M; Cichero, Julie A Y; Stokes, Jason R; Steadman, Kathryn J

2014-01-01

To evaluate the influence of co-administered vehicles on in vitro dissolution in simulated gastric fluid of crushed immediate release tablets as an indicator for potential drug bioavailability compromise. Release and dissolution of crushed amlodipine, atenolol, carbamazepine and warfarin tablets were tested with six foods and drinks that are frequently used in the clinical setting as mixers for crushed medications (water, orange juice, honey, yoghurt, strawberry jam and water thickened with Easythick powder) in comparison to whole tablets. Five commercial thickening agents (Easythick Advanced, Janbak F, Karicare, Nutilis, Viscaid) at three thickness levels were tested for their effect on the dissolution of crushed atenolol tablets. Atenolol dissolution was unaffected by mixing crushed tablets with thin fluids or food mixers in comparison to whole tablets or crushed tablets in water, but amlodipine was delayed by mixing with jam. Mixing crushed warfarin and carbamazepine tablets with honey, jam or yoghurt caused them to resemble the slow dissolution of whole tablets rather than the faster dissolution of crushed tablets in water or orange juice. Crushing and mixing any of the four medications with thickened water caused a significant delay in dissolution. When tested with atenolol, all types of thickening agents at the greatest thickness significantly restricted dissolution, and products that are primarily based on xanthan gum also delayed dissolution at the intermediate thickness level. Dissolution testing, while simplistic, is a widely used and accepted method for comparing drug release from different formulations as an indicator for in vivo bioavailability. Thickened fluids have the potential to retard drug dissolution when used at the thickest levels. These findings highlight potential clinical implications of the addition of these agents to medications for the purpose of dose delivery and indicate that further investigation of thickened fluids and their

Extracorporeal Detoxification in Victims with Severe Concomitant Injury

Directory of Open Access Journals (Sweden)

S. Ye. Khoroshilov

2009-01-01

Full Text Available Objective: to improve the results of victims with massive crushes of soft tissues in severe concomitant injury (SCI, by applying extracorporeal detoxification techniques as soon as possible. Subjects and methods. The results of examination and treatment were studied in 41 victims with SCI treated at the N. N. Burdenko Main Military Clinical Hospital in 2006 to 2008. In the early posttraumatic period (on days 1—3, all the victims (n=41 were divided into 2 groups. Group 1 victims (n=19 underwent hemodiafiltration (HDF with replacement at 35 ml/kg/hr; Group 2 (n=22 had plasmapheresis. Results. Early HDF applied to Group 1 victims could achieve 32, 44, and 37% reductions in the elevated levels creatine phosphokinase, myoglobin, and middle-sized molecules, respectively. In Group 2, plasmapheresis showed a lower effect (19, 25, and 26% reductions. Furthermore, there was a decrease in total protein in Group 1, which was absent in Group 2. Conclusion. The timely use of extracorporeal detoxification techniques in victims with massive crushes of soft tissues in the early posttraumatic period prevents the development of fatal complications of SCI, at the same time HDF is more effective and safe than plasmapheresis. Key words: severe concomitant injury, rhabdomyolysis, myoglobin, plasmapheresis, hemodiafiltration.

Crushed rock sand – An economical and ecological alternative to natural sand to optimize concrete mix

Directory of Open Access Journals (Sweden)

Sanjay Mundra

2016-09-01

Full Text Available The study investigates the use of crushed rock sand as viable alternative to Natural River sand that is being conventionally used as fine aggregate in cement concrete. Various mix designs were developed for different grades of concrete based on IS, ACI and British codes using Natural River sand and crushed rock sand. In each case, the cube compressive strength test, and beam flexure tests were conducted. The results of the study show that, the strength properties of concrete using crushed rock sand are nearly similar to the conventional concrete. The study has shown that crushed stone sand can be used as economic and readily available alternative to river sand and can therefore help to arrest the detrimental effects on the environment caused due to excessive mining of river sand.

Distribution of crushing strength of tablets

DEFF Research Database (Denmark)

Sonnergaard, Jørn

2002-01-01

The distribution of a given set of data is important since most parametric statistical tests are based on the assumption that the studied data are normal distributed. In analysis of fracture mechanics the Weibull distribution is widely used and the derived Weibull modulus is interpreted as a mate...... data from nine model tablet formulations and four commercial tablets are shown to follow the normal distribution. The importance of proper cleaning of the crushing strength apparatus is demonstrated....

Dietary supplement with fermented soybeans, natto, improved the neurobehavioral deficits after sciatic nerve injury in rats.

Science.gov (United States)

Pan, Hung-Chuan; Cheng, Fu-Chou; Chen, Chun-Jung; Lai, Shu-Zhen; Liu, Mu-Jung; Chang, Ming-Hong; Wang, Yeou-Chih; Yang, Dar-Yu; Ho, Shu-Peng

2009-06-01

Clearance of fibrin and associated inflammatory cytokines by tissue-type plasminogen activator (t-PA) is related to improved regeneration in neurological disorder. The biological activity of fermented soybean (natto) is very similar to that of t-PA. We investigated the effect of the dietary supplement of natto on peripheral nerve regeneration. The peripheral nerve injury was produced by crushing the left sciatic nerve with a vessel clamp in Sprague-Dawley rats. The injured animals were fed orally either with saline or natto (16 mg/day) for seven consecutive days after injury. Increased functional outcome such as sciatic nerve functional index, angle of ankle, compound muscle action potential and conduction latency were observed in natto-treated group. Histological examination demonstrated that natto treatment improved injury-induced vacuole formation, S-100 and vessel immunoreactivities and axon loss. Oral intake of natto prolonged prothrombin time and reduced fibrinogen but did not change activated partial thromboplastin time and bleeding time. Furthermore, natto decreased injury-induced fibrin deposition, indicating a tolerant fibrinolytic activity. The treatment of natto significantly improved injury-induced disruption of blood-nerve barrier and loss of matrix component such as laminin and fibronectin. Sciatic nerve crush injury induced elevation of tumor necrosis factor alpha (TNF-alpha) production and caused apoptosis. The increased production of TNF-alpha and apoptosis were attenuated by natto treatment. These findings indicate that oral intake of natto has the potential to augment regeneration in peripheral nerve injury, possibly mediated by the clearance of fibrin and decreased production of TNF-alpha.

A local isotropic/global orthotropic finite element technique for modeling the crush of wood in impact limiters

International Nuclear Information System (INIS)

Attaway, S.W.; Yoshimura, H.R.

1989-01-01

Wood is often used as the energy absorbing material in impact limiters, because it begins to crush at low strains, then maintains a near constant crush stress up to nearly 60% volume reduction, and then locks up. Hill (Hill and Joseph, 1974) has performed tests that show that wood is an excellent absorber. However, wood's orthotropic behavior for large crush is difficult to model. In the past, analysts have used isotropic foam-like material models for modeling wood. A new finite element technique is presented in this paper that gives a better model of wood crush than the model currently in use. The orthotropic technique is based on locally isotropic, but globally orthotropic (LIGO) (Attaway, 1988) assumptions in which alternating layers of hard and soft crushable material are used. Each layer is isotropic; however, by alternating hard and soft thin layers, the resulting global behavior is orthotropic. In the remainder of this paper, the new technique for modeling orthotropic wood crush will be presented. The model is used to predict the crush behavior for different grain orientations of balsa wood. As an example problem, an impact limiter containing balsa wood as the crushable material is analyzed using both an isotropic model and the LIGO model

Nutritional parameters of steers receiving different levels of sunflower crushed in partial replacement of soybean meal

Directory of Open Access Journals (Sweden)

HELLEN L. LIMA

2013-10-01

Full Text Available ABSTRACT To evaluate of the sunflower crushed in nutritional parameters in steers, supplemented at pasture, we used four steers in 4×4 Latin square design. The supplements were provided in 6 g/kg of body weight/animal/day, consisting of sunflower crushed, corn, soybean meal and mineral. All the supplements was isonitrogenous and soybean meal was replaced in 0, 20, 40, and 60% for sunflower crushed. The determination of ruminal pH and ammonia was at 0, 2, 4, 6 and 8 h. after feeding and for short-chain fatty acids it was collected at 0 and 6 h. post-feeding. The dry matter intake was not affected (P>0.05 by inclusion of sunflower crushed (mean=6.59 kg/day. There was no significant effect (P>0.05 for pH for the inclusion of sunflower crushed (mean=6.41. For contents of ruminal NH3-N was a significant effect (P <0.05 only for collection time, and ammonia peaks occurred between 2 and 4 h after feeding, with values of 22.56 and 21.40 mg/dL. The total concentration of short chain fatty acids and the C2:C3 ratio was reduced in 9.6 and 15.43%. The ruminal degradability of NDF was not affected by the supplements. The supplementation with sunflower crushed to beef steers grazing, in partial replacement of soybean meal did not alter nutrition parameters.

Boric acid reduces axonal and myelin damage in experimental sciatic nerve injury

Directory of Open Access Journals (Sweden)

Zahir Kizilay

2016-01-01

Full Text Available The aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into four equal groups (n = 7: control (C, boric acid (BA, sciatic nerve injury (I , and sciatic nerve injury + boric acid treatment (BAI. Sciatic nerve injury was generated using a Yasargil aneurysm clip in the groups I and BAI. Boric acid was given four times at 100 mg/kg to rats in the groups BA and BAI after injury (by gavage at 0, 24, 48 and 72 hours but no injury was made in the group BA. In vivo electrophysiological tests were performed at the end of the day 4 and sciatic nerve tissue samples were taken for histopathological examination. The amplitude of compound action potential, the nerve conduction velocity and the number of axons were significantly lower and the myelin structure was found to be broken in group I compared with those in groups C and BA. However, the amplitude of the compound action potential, the nerve conduction velocity and the number of axons were significantly greater in group BAI than in group I. Moreover, myelin injury was significantly milder and the intensity of nuclear factor kappa B immunostaining was significantly weaker in group BAI than in group I. The results of this study show that administration of boric acid at 100 mg/kg after sciatic nerve injury in rats markedly reduces myelin and axonal injury and improves the electrophysiological function of injured sciatic nerve possibly through alleviating oxidative stress reactions.

Assessment of crushed salt consolidation and fracture healing processes in a nuclear waste repository in salt

International Nuclear Information System (INIS)

1984-11-01

For a nuclear waste repository in salt, two aspects of salt behavior are expected to contribute to favorable conditions for waste isolation. First, consolidation of crushed salt backfill due to creep closure of the underground openings may result in a backfill barrier with low permeability. Second, fractures created in the salt by excavation may heal under the influence of stress and temperature following sealing. This report reviews the status of knowledge regarding crushed salt consolidation and fracture healing, provides analyses which predict the rates at which the processes will occur under repository conditions, and develops requirements for future study. Analyses of the rate at which crushed salt will consolidate are found to be uncertain because of unexplained wide variation in the creep properties of crushed salt obtained from laboratory testing, and because of uncertainties in predictions of long term closure rates of openings in salt. This uncertainty could be resolved to a large degree by additional laboratory testing of crushed salt. Similarly, additional testing of fracture healing processes is required to confirm that healing will be effective under repository conditions. Extensive references, 27 figures, 5 tables

Treatment of solid waste highly contaminated by alpha emitters low-temperature impact crushing/leaching and incineration

International Nuclear Information System (INIS)

Carpentier, S.; Bertolotti, G.

1986-01-01

Reprocessing plants, hot laboratories, fuel fabrication plants all produce waste containing residual quantities of plutonium and uranium in oxide form which often reach some tens of grammes per m 3 . Appropriate treatment recovers an appreciable amount of fissile material, which could lead to the waste being declassified and able to be disposed of in near ground-level facilities. After a summary sorting at production level, waste can be sent to a low-temperature impact crushing/leaching unit which considerably reduces volumes to be stored. We call this process cryo-crushing/leaching. For burnable crushed particles, a further volume reduction may be obtained by incineration, an operation which is made easier by the low fissile material residue content. Incineration can, of course also be applied directly to burnable solid waste sorted at source and crushed following more conventional methods [fr

Immune cell distribution and immunoglobulin levels change following sciatic nerve injury in a rat model

Directory of Open Access Journals (Sweden)

Wei Yuan

2016-07-01

Full Text Available Objective(s: To investigate the systemic and local immune status of two surgical rat models of sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection Materials and Methods:Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group, sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was performed. The percentage of CD4+ cells and the CD4+/CD8+ratio were determined by flow cytometry. Serum IgM and IgG levels were analyzed by ELISA. T-cells (CD3 and macrophages (CD68 in sciatic nerve tissue sections were identified through immunohistochemistry. Results: Compared to sham-operated controls, in rats that underwent nerve injury, the percentage of CD4+ cells and the CD4+/CD8+ ratio in the peripheral blood were significantly  decreased 7 days after surgery, serum IgM levels were increased 14 days after surgery, and serum IgG levels were increased 21 days after surgery. There were a large number of CD3+ cells and a small number of CD68+ cells in sciatic nerve tissue sections 21 days after surgery, indicating T-cell and macrophage activation and infiltration. Local IgG deposition was also detected at the nerve injury site 21 days after surgery. Conclusion: Rat humoral and cellular immune status changed following sciatic nerve injury, particularly with regard to the cellular immune response at the nerve injury site.

Optimal energy control of a crushing process based on vertical shaft impactor

International Nuclear Information System (INIS)

Numbi, B.P.; Xia, X.

2016-01-01

Highlights: • Energy optimal control strategy of a VSI crushing process is modeled. • Potential of a daily energy cost saving of about 49.7% is shown. • Potential of a daily energy saving of about 15.3% is shown. • Most of energy cost saving is due to the optimal load shifting under time-of-use tariff. • Energy saving is due to the operation of the process at the boundary of the admissible region. - Abstract: This paper presents an optimal control model to improve the operation energy efficiency of a vertical shaft impact (VSI) crushing process. The optimal control model takes the energy cost as the performance index to be minimized by accounting for the time-of-use tariff and process constraints such as storage capacity of the VSI crusher hopper, capacity of the main storage system, flow rate limits, cascade ratio setting, production requirement and product quality requirement. The control variables in the developed model are the belt conveyor feed rate, the material feed rate into the VSI crusher rotor, the bi-flow or cascade feed rate and the rotor tip speed of the crusher. These four control variables are optimally coordinated in order to improve the operation energy efficiency of the VSI crushing process. Simulation results based on a crushing process in a coal-fired power plant demonstrate a potential of a daily energy cost saving of about 49.7% and energy saving of about 15.3% in a high-demand season weekday.

Injuries and Fatalities in Danish Commercial Fishing Fleet in 1998–2016

DEFF Research Database (Denmark)

Rasmussen, Hanna Barbara; Ahsan, Dewan

2018-01-01

and the remaining injuries resulted in sick leave of more than one day; 52.5% (n = 600) of reported injuries involved fishermen who have less than one year’s experience of employment; 29% (n = 407) of injuries took place between 12:00 and 16:00, and the second largest number of injuries, 23.3% (n = 324), took place...... fisheries. Result: The results showed decreased injuries in the study period from 45 injuries and deaths per 1000 fishermen reported to the authorities to 12 injuries and deaths per 1000 fishermen in 2016: 2.1% (n = 39) of all reported injuries in the study period resulted in the death of a fisherman...... between 8:00 and 12:00. The incident rate of slip/fall injuries has decreased from 10.06 per 1000 fishermen in 1998 to 3.84 in 2016. The incidence rate of injuries caused by crushing also decreased, from 9.32 accidents per 1000 fishermen in 1998 to 2.56 in 2016. Most of the injuries, 74.5% (n = 1307...

environmental impact of aggregate mining by crush rock industries

African Journals Online (AJOL)

2012-07-02

Jul 2, 2012 ... in form of crushed rock and it is also an essential con- stituent of many ... of production; processing or during extraction. Since .... reserves through deep quarrying. 1.3. ...... Audit Report of Port Harcourt Flour Mill Port Har- court.

Current status of crushed rock and whole rock column studies

International Nuclear Information System (INIS)

Vine, E.N.; Daniels, W.R.; Rundberg, R.S.; Thompson, J.L.

1980-01-01

Measurements on a large number of crushed rock columns of tuff, granite, and argillite are discussed. The isotopes 85 Sr, 137 Cs, 133 Ba, 141 Ce, 152 Eu, /sup 95m/Tc, and 233 U were used. Flow rates were varied from approx. 30 to approx. 30000 m/y. Other parameters studied include isotope concentration and atmosphere. The sorption ratios calculated were compared with batch sorption ratios on the same samples. Methods of studying the movement of radionuclides through whole rock cores are described. The problems associated with sealing the cores to prevent leaking along the exterior surface and one possible solution are discussed. The strontium sorption ratio obtained by elution of one solid tuff core is compared with the batch and crushed rock column sorption ratios

Utilization of crushed clay brick in concrete industry

Directory of Open Access Journals (Sweden)

Ali A. Aliabdo

2014-03-01

Full Text Available A comprehensive experimental program regarding the use of recycled aggregates produced from demolition of brick buildings is presented. The brick wastes were crushed, sorted and classified into coarse and fine aggregates as well as powder (CBP. The first phase of the research focuses on the effect of incorporating recycled aggregates on physico-mechanical properties of paste, mortar and concrete. Non-traditional tests including X-ray diffraction (XRD, thermo-gravimetric analysis (TGA and micro-structural analysis (MSA were performed. The second phase of the program explores the effect of using recycled aggregates on properties of concrete masonry units. A total of 44 mixtures were utilized throughout the program. Results show cement paste when modified with 25% CBP achieves smaller pore size and lower weight loss under high temperature than reference paste. Furthermore, the use of recycled aggregates reduces the overall unit weight of concrete masonry units. Actually, modified concrete masonry units incorporating recycled aggregates achieve lower unit weight, higher thermal resistance and absorption rate than reference units. Although considerable strength reduction is noticeable by substitution, compressive strength levels meet the Egyptian specifications limitations. Critical replacement ratios are suggested to produce load bearing-concrete masonry units. Based on experimental evidences, it can be stated that the use of recycled aggregate and dust made of clay bricks is promising in many applications where the thermal resistance, cost and environmental aspects are imperative.

MR manifestation of lower extremity rhabdomyolysis caused by crush injury in earthquake

International Nuclear Information System (INIS)

Li Zhengyan; Zou Ling; Song Bin; Liu Chang; Sun Jiayu; Zhang Weiwei; Zhang Cuiping

2008-01-01

Objective: Rhabdomyolysis (RM) is a common disorder resulting from a large variety of causes. Acute injury is one of the main reasons. The purpose is to describe the MRI manifestations of rhabdomyolysis caused by 5.12 Wenchuan earthquake in Sichuan province and to discuss their importance in diagnosis and treatment of rhabdomyolysison in clinic practice. Methods: Three patients with rhabdomyolysis caused by earthquake were studied via 1.5 T MRI. In all the patients, T 1 and T 2 weighted sequences with and without fat suppression, and short time inversion recovery (STIR) of both lower extremities were obtained in axial, coronal and sagittal planes. All patients were given contrast material during imaging, and MRA (magnetic resonance angiography) of both lower extremity vessels were performed. The MRI characteristics of damaged extremities in 3 cases were studied. Results: MRI showed swelling of the affected muscles and subcutaneous fat tissue on both T 1 and T 2 weighted images. The margins of involved muscles were blurred. On T 1 weighted images, swollen muscles showed equal or slightly decreased intensity with small patterns of increased intensity in some local areas. On T 2 weighted and STIR sequences, the affected muscles showed inhomogeneous increased signal intensity with clearer margin. Slight fluid collection in spatium intermusculare was observed. Contrast-enhanced scanning showed nonhomologous intensification of damaged muscles, the enhancement inside the muscles was decreased when compared with normal muscles. The locations of all these abnormal intensity were correlated with the injury history and clinic physical examinations. MRA showed no lower extremity vessels were affected. Conclusion: MRI has very high sensitivity in detecting the injury of muscles. It's very useful in evaluating the extent and severity of muscles affected in rhabdomyolysis caused by trauma. Also it's very valuable to evaluate the condition of blood vessels in involved extremity

The effect of ozone and naringin on intestinal ischemia/reperfusion injury in an experimental model.

Science.gov (United States)

Isik, Arda; Peker, Kemal; Gursul, Cebrail; Sayar, Ilyas; Firat, Deniz; Yilmaz, Ismayil; Demiryilmaz, Ismail

2015-09-01

The aim of the study was to evaulate the effect of ozone and naringin on the intestine after intestinal ischemia-reperfusion(II/R) injury. Thirty five rats divided into 5 groups of 7 animals: control, II/R, ozone, naringin and naringin + ozone. Only laparotomy and exploration of the superior mesenteric artery (SMA) were done in control group. In the experimental groups, SAM was occluded for 1 h and reperfused for 1 h. 15 min after ischemia, ozone (25 μg/ml, 0.5 mg/kg), naringin (80 mg/kg) and naringin + ozone(80 mg/kg + 25 μg/ml, 0.5 mg/kg) were infused intraperitoneally to each groups. Ileum tissues were harvested to determine intestinal mucosal injury and oxidative stress markers. For SMA occlusion, different than literature, silk suture binding was used. Oxidative stress markers were significantly low in experimental groups compared with II/R group (p < 0.05). Histopathologically, the injury score was significantly low at experimental groups compared with II/R group (p < 0.05). The lowest injury score was encountered at naringine + ozone group. Ozone alone or combined with naringin has a protective effect for mesenteric ischemia. Instead of using instruments such as clamps in the II/R rat model, silk binding may be used safely. Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

Experimental perforating injury with high energy electrons to inhibit intraocular proliferation

International Nuclear Information System (INIS)

Velikay, M.; Binder, S.; Stolba, U.; Wedrich, AJ.; Datlinger, P.; Handl-Zeller, L.

1994-01-01

Since 1980, the fibroblast model creating experimental proliferative vitreoretinopathy has been used to evaluate the antiproliferative effect of various drugs. In previous studies radiation therapy was found to reduce effectively intraocular proliferation in this model. We therefore investigated the effect of high energy electrons in a standard perforating injury model creating a traumatic proliferative vitreoretinopathy. In 36 eyes we performed a 8 mm pars plana incision and injected 0.4 ml of 80% fibronection solution intravitreally. Ten rabbits (20 eyes) received radiation therapy with a Betatron accelerator in a total dosage of 3000 cGy to each eye divided into 10 single fractions starting on the first post-operative day. Maximum concentration of the dose was focused to the posterior vitreous. The other 9 rabbits, 18 eyes, served as control. In our perforating injury model we observed a reduction of retinal detachment rate of 72% in the controls to 55% in the treated group. The effect of radiation therapy with high energy electrons and total dosage of 3000 cGy was not statistically significant in experimental traumatic proliferative vitreoretinopathy. (au) (12 refs.)

Analysis of the crush environment for lightweight air-transportable accident-resistant containers

International Nuclear Information System (INIS)

McClure, J.D.; Hartman, W.F.

1981-12-01

This report describes the longitudinal dynamic crush environment for a Lightweight Air-Transportable Accident-Resistant Container (LAARC, now called PAT-2) that can be used to transport small quantities of radioactive material. The analysis of the crush environment involves evaluation of the forces imposed upon the LAARC package during the crash of a large, heavily loaded, cargo aircraft. To perform the analysis, a cargo load column was defined which consisted of a longitudinal prism of cargo of cross-sectional area equal to the projected area of the radioactive-material package and length equal to the longitudinal extent of the cargo compartment in a commercial cargo jet aircraft. To bound the problem, two analyses of the cargo load column were performed, a static stability analysis and a dynamic analysis. The results of these analyses can be applied to other packaging designs and suggest that the physical limits or magnitude of the longitudinal crush forces, which are controlled in part by the yield strength of the cargo and the package size, are much smaller than previously estimated

Nitrate removal from aquaculture effluents using woodchip bioreactors improved by adding sulfur granules and crushed seashells

DEFF Research Database (Denmark)

von Ahnen, Mathis; Pedersen, Per Bovbjerg; Dalsgaard, Johanne

2018-01-01

This study examined the effects on nitrate removal when adding sulfur granules and crushed seashells to a woodchip bioreactor treating aquaculture effluents. Using a central composite design, the two components were added at three levels (0.000, 0.125 and 0.250 m3/m3 bioreactor volume) to 13......, the inclusion of crushed seashells together with sulfur granules helped to maintain the pH above 7.4 and prevent a production (i.e., release) of nitrite. According to the modeled response surfaces, a sulfur granule:crushed seashell:woodchip mixture ratio containing about 0.2 m3 sulfur granules and 0.1 m3...... crushed seashells per m3 reactor volume would give the best results with respect to high N removal and minimal nitrite release. In conclusion, the study showed that N removal in woodchip bioreactors may be improved by adding sulfur granules and seashells, contributing to the optimization of woodchip...

Treatment of solid waste highly contaminated by alpha emitters: Low-temperature impact crushing, leaching and incineration

International Nuclear Information System (INIS)

Bertolotti, G.; Vigreux, B.; Caillol, A.; Koehly, G.

1987-01-01

Reprocessing plants, hot laboratories and fuel fabrication plants produce solid wastes containing residual amounts of plutonium and uranium in nitrate and oxide form at concentrations up to several tens of grams per m/sup 3/. Dismantling of nuclear facilities having handled these radioelements also generates large volumes of solid wastes highly contaminated with alpha emitters. It is desirable to process these alpha wastes to recover valuable fissile materials and/or permit surface storage. Solid waste treatment by low-temperature impact crushing and then leaching, after minimal sorting and classifying at the sites of production, meets the corresponding requirements for high volume reduction plus fissile material recovery or waste decontamination. Additional volume reduction of crushed wastes containing mainly combustible materials can be obtained by incineration. This is facilitated by the low fissile material content after low-temperature impact crushing and leaching. Sorted wastes can also be leached or incinerated directly after, in most cases, crushing by more conventional techniques

Crushed aggregates for roads and their properties for frost protection

Science.gov (United States)

Kuznetsova, Elena; Willy Danielsen, Svein

2015-04-01

Crushed aggregates for roads and their properties for frost protection Elena Kuznetsova, NTNU and Svein Willy Danielsen, SINTEF With natural (fluvial, glaciofluvial) sand/gravel resources being rapidly depleted in many countries, the last decade has seen a significant trend towards using more alternative materials for construction purpose. In Norway the development and implementation of crushed aggregate technology has been the most important way to get around the problem with increased resource scarcity. Today Norway is one the European countries with the highest percentage of crushed/manufactured aggregates. A crushed product will reveal a different particle size distribution, a sharper, more angular particle shape, and not least - a significantly different mineral composition. The latter may often be characterised by more polymineral composition, and it will also much more depend on the local bedrock. When handled with care and knowledge, these differences can give the user a lot of new opportunities relating to materials design. Norwegian road construction practice has changed significantly during the last 40 years due to the replacement of gravel by crushed rock materials in the granular layers of the pavements. The use of non-processed rock materials from blasting was allowed in the subbase layer until 2012. This was a reason for a lot of problems with frost heaving due to inhomogeneity of this material, and in practice it was difficult to control the size of large stones. Since 2012 there is a requirement that rock materials for use in the subbase layer shall be crushed (Handbook N200, 2014). During the spring 2014 The Norwegian Public Roads Administration introduced a new handbook with requirements for roads construction in Norway, including new specifications for the frost protection layer. When pavements are constructed over moist and/or frost susceptible soils in cold and humid environments, the frost protection layer also becomes a very important part

Primary amenorrhea caused by crushing trauma of the pelvis

NARCIS (Netherlands)

Donner, G. G.; Pel, M.; Lammes, F. B.

2000-01-01

An 18-year-old woman sought treatment for primary amenorrhea. Crushing trauma of the pelvis in her childhood had caused separation between the uterine corpus and the cervix. Through a combined abdominal and vaginal approach the continuity of the uterine outflow tract was restored. Years later, after

Crushing and Fracture of Lightweight Structures

DEFF Research Database (Denmark)

Urban, Jesper

2003-01-01

and Latham (1968). Good agreement between the analytical models and the experiments is found. The crushing behaviour of two high speed ferries has been analysed with the numerical and analytical methods and the results are compared with the existing regulations for high speed craft (HSC). Several failure......The overall objective of the present study has been to develop rational analytical and numerical calculation models to quantify the consequences of collision accidents. The work has primarily been focused on high speed craft (HSC) built in lightweight materials such as aluminium and sandwich...

Improvements of Spiers model for compaction creep of crushed rock salt

International Nuclear Information System (INIS)

Poley, A.D.

1996-10-01

This report describes a number of improvements to the existing model for the process of compaction creep of rock salt developed by Spiers and co-workers. The process of compaction creep determines the behaviour of the seals of crushed rock salt, the last engineered barriers of a repository in rock salt for (radioactive) wastes. In Chapter 2 the derivation of the original model of Spiers and co-workers is followed except for some simplifying approximations. A comparison of the model results is made with experimental data and a number of model adjustments are suggested. In Chapter 3 one of these suggested model adjustments is explored, and an alternative model is developed. The results obtained with this model compare favourably with the experimental data without the use of adjustable shape functions as for the original model. Preliminary investigations of the impact of the new model on estimated releases to the geosphere of radionuclides form a repository in rock salt revealed striking differences: with the new model the compaction of the rock salt seals was so rapid that no releases could occur. The striking differences between the results - in terms of releases form a rock salt repository to the geosphere after groundwater intrusion - obtained using the two models clearly indicate the need for further experimental research into the end-compaction behaviour of rock salt backfill. (orig.)

Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr. Pers. through its neuroregenerative action

Directory of Open Access Journals (Sweden)

Kah-Hui WONG

2015-01-01

Full Text Available Abstract Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. We investigated the ability of polysaccharide from Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats by daily oral administration. In sensory functional recovery test, the time taken for the rats to withdraw its hind limb from contact with the hot plate was measured. The test revealed acceleration of sensory recovery in the polysaccharide group compared to negative controls. Further, peripheral nerve injury leads to changes at the remotely located DRG containing cell bodies of sensory neurons. Immunofluorescence studies showed that Akt and p38 MAPK were expressed in DRG and strongly upregulated in polysaccharide group after peripheral nerve injury. The intensity of endothelial cells antigen-1 that recognized endothelial cells in the blood vessels of distal segments in crushed nerves was significantly higher in the treated groups than in the negative control group. Our findings suggest that H. erinaceus is capable of accelerating sensory functional recovery after peripheral nerve injury and the effect involves the activation of protein kinase signaling pathways and restoration of blood-nerve barrier.

Epiphyseal injuries of the distal tibia. Does MRI provide useful additional information?

International Nuclear Information System (INIS)

Iwinska-Zelder, J.; Schmidt, S.; Ishaque, N.; Klose, K.J.; Hoppe, M.; Schmitt, J.; Gotzen, L.

1999-01-01

Plain film radiography often underestimates the extent of injury in children with epiphyseal fracture. Especially Salter-Harris V fractures (crush fracture of the epiphyseal plate) are often primarily not detected. MRI of the ankle was performed in 10 children aged 9-17 (mean 14) years with suspected epiphyseal injury using 1.0-T Magnetom Expert. The fractures were classified according to the Salter-Harris-Rang-Odgen classification and compared with the results of plain radiography. In one case MRI could exclude epiphyseal injury; in four cases the MRI findings changed the therapeutic management. The visualisation of the fracture in three orthogonal planes and the possibility of detection of cartilage and ligamentous injury in MR imaging makes this method superior to conventional radiography and CT. With respect to radiation exposure MRI instead of CT should be used for the diagnosis of epiphyseal injuries in children. (orig.) [de

Recovery of function, peripheral sensitization and sensory neurone activation by novel pathways following axonal injury in Aplysia californica.

Science.gov (United States)

Dulin, M F; Steffensen, I; Morris, C E; Walters, E T

1995-10-01

Recovery of behavioural and sensory function was examined following unilateral pedal nerve crush in Aplysia californica. Nerve crush that transected all axons connecting the tail to the central nervous system (CNS) eliminated the ipsilateral tail-evoked siphon reflex, whose sensory input travels in the crushed tail nerve (p9). The first reliable signs of recovery of this reflex were observed within 1 week, and most animals displayed tail-evoked siphon responses within 2 weeks. Wide-dynamic-range mechanosensory neurons with somata in the ventrocaudal (VC) cluster of the ipsilateral pleural ganglion exhibited a few receptive fields (RFs) on the tail 3 weeks after unilateral pedal nerve crush, indicating that the RFs had either regenerated or been reconnected to the central somata. These RFs were smaller and sensitized compared with corresponding RFs on the contralateral, uncrushed side. Centrally conducted axon responses of VC sensory neurones to electrical stimulation distal to the nerve crush site did not reappear until at least 10 days after the crush. Because the crush site was much closer to the CNS than to the tail, the failure of axon responses to be restored earlier than the behavioural responses indicates that early stages of reflex recovery are not due to regeneration of VC sensory neurone axons into the tail. Following nerve crush, VC sensory neurones often could be activated by stimulating central connectives or peripheral nerves that do not normally contain the sensory neurone's axons. These results suggest that recovery of behavioral function after nerve injury involves complex mechanisms, including regenerative growth of axotomized VC sensory neurones, sensitization of regenerating RFs and sprouting of VC sensory neurone fibres within the CNS. Furthermore, the rapidity of behavioural recovery indicates that its initial phases are mediated by additional mechanisms, perhaps centripetal regeneration of unidentified sensory neurones having peripheral

Cryptanalysis of an Iterated Halving-based hash function: CRUSH

DEFF Research Database (Denmark)

Bagheri, Nasour; Henricksen, Matt; Knudsen, Lars Ramkilde

2009-01-01

Iterated Halving has been suggested as a replacement to the Merkle–Damgård (MD) construction in 2004 anticipating the attacks on the MDx family of hash functions. The CRUSH hash function provides a specific instantiation of the block cipher for Iterated Halving. The authors identify structural pr...

Effect of Fucoidan Extracted from Mozuku on Experimental Cartilaginous Tissue Injury 

Directory of Open Access Journals (Sweden)

Saburo Minami

2012-11-01

Full Text Available We investigated the effect of fucoidan, a sulfated polysaccharide, on acceleration of healing of experimental cartilage injury in a rabbit model. An injured cartilage model was surgically created by introduction of three holes, one in the articular cartilage of the medial trochlea and two in the trochlear sulcus of the distal femur. Rabbits in three experimental groups (F groups were orally administered fucoidan of seven different molecular weights (8, 50, 146, 239, 330, 400, or 1000 kD for 3 weeks by screening. Control (C group rabbits were provided water ad libitum. After the experimental period, macroscopic examination showed that the degree of filling in the fucoidan group was higher than that in the C group. Histologically, the holes were filled by collagen fiber and fibroblasts in the C group, and by chondroblasts and fibroblasts in the F groups. Image analysis of Alcian blue- and safranin O-stained F-group specimens showed increased production of glycosaminoglycans (GAGs and proteoglycans (PGs, respectively. Some injured holes were well repaired both macroscopically and microscopically and were filled with cartilage tissues; cartilage matrices such as PGs and GAGs were produced in groups F 50, F 146, and F 239. Thus, fucoidan administration enhanced morphologically healing of cartilage injury.

An emerging etiological factor for hand injuries in the pediatric population: public exercise equipment.

Science.gov (United States)

Akşam, Berrak; Akşam, Ersin; Ceran, Candemir; Demirseren, Mustafa Erol

2016-01-01

The purpose of this study was to describe the role of public exercise equipment in pediatric hand traumas as a preventable etiological factor. Pediatric patients with hand injuries referred from the emergency department were evaluated retrospectively. Age and gender of the patients, timing, etiology, mechanism of hand trauma, localization of the injury, diagnoses of the patients, and hospitalization rates were reviewed. Amongst the 310 pediatric patients evaluated, 31 patients (10%) experienced injury related to public exercise equipment. Within this group of patients, most were between 5 to 9 years of age, and all injuries were blunt and crush type. Lacerations and fractures were the main diagnoses. Complex injuries that required inpatient care were reported in 19.3% of the patients. Public exercise equipment-related injuries are increasingly prevalent in pediatric hand traumas. Preventive actions such as shielding the moving parts should be taken to reduce these rates.

Remediation of muddy tidal flat sediments using hot air-dried crushed oyster shells.

Science.gov (United States)

Yamamoto, Tamiji; Kondo, Shunsuke; Kim, Kyung-Hoi; Asaoka, Satoshi; Yamamoto, Hironori; Tokuoka, Makoto; Hibino, Tadashi

2012-11-01

In order to prove that hot air-dried crushed oyster shells (HACOS) are effective in reducing hydrogen sulfide in muddy tidal flat sediments and increasing the biomass, field experiments were carried out. The concentration of hydrogen sulfide in the interstitial water, which was 16 mg SL(-1) before the application of HACOS, decreased sharply and maintained almost zero in the experimental sites (HACOS application sites) for one year, whereas it was remained at ca. 5 mg SL(-1) in the control sites. The number of macrobenthos individuals increased to 2-4.5 times higher than that in the control site. Using a simple numerical model, the effective periods for suppression of hydrogen sulfide were estimated to be 3.2-7.6 and 6.4-15.2 years for the experimental sites with 4 and 8 tons per 10 × 10 × 0.2m area, respectively. From these results, it is concluded that HACOS is an effective material to remediate muddy tidal flats. Copyright © 2012 Elsevier Ltd. All rights reserved.

suitability of burnt and crushed cow bones as partial replacement

African Journals Online (AJOL)

HOD

3 mix ratio measuring 150x150x150mm were tested for the compressive strength at 7, 14, 21 and 28 days respectively. ... the suitability of using waste products to produce lightweight ... suitability of machine crushed animal bones as partial or.

Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma.

Directory of Open Access Journals (Sweden)

Harry A Quigley

Full Text Available To determine if oral losartan treatment decreases the retinal ganglion cell (RGC death caused by experimental intraocular pressure (IOP elevation in mice.We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone, enalapril, or no drug to test effects of inhibiting angiotensin receptors. IOP was monitored by Tonolab, and blood pressure was monitored by tail cuff device. RGC loss was measured in masked axon counts and RGC bodies by β-tubulin labeling. Scleral changes that could modulate RGC injury were measured including axial length, scleral thickness, and retinal layer thicknesses, pressure-strain behavior in inflation testing, and study of angiotensin receptors and pathways by reverse transcription polymerase chain reaction, Western blot, and immunohistochemistry.Losartan treatment prevented significant RGC loss (median loss = 2.5%, p = 0.13, while median loss with water, spironolactone, and enalapril treatments were 26%, 28% and 43%; p < 0.0001. The lower RGC loss with losartan was significantly less than the loss with spironolactone or enalapril (regression model p = 0.001; drug treatment group term p = 0.01. Both losartan and enalapril significantly lowered blood pressure (p< 0.001, but losartan was protective, while enalapril led to worse than water-treated RGC loss. RGC loss after crush injury was unaffected by losartan treatment (difference from control p = 0.9. Survival of RGC in cell culture was not prolonged by sartan treatment. Axonal transport blockade after 3 day IOP elevations was less in losartan-treated than in control glaucoma eyes (p = 0.007. Losartan inhibited effects of glaucoma, including reduction in extracellular signal-related kinase activity and modification of glaucoma-related changes in scleral thickness and creep under controlled IOP.The neuroprotective effect of losartan in mouse glaucoma is associated with adaptive changes in the sclera expressed at

Deformations during saturation of the crushed aggregate, Olkiluoto tonalite

International Nuclear Information System (INIS)

Laaksonen, R.; Rathmayer, H.; Takala, J.; Toernqvist, J.

1994-03-01

Crushed aggregate tonalite produced of crystalline tonalite or a correspondent rock with particle size up to 8 mm (or 16 mm) will be used as backfill material in the VLJ repository caverns at Olkiluoto (in Finland). The backfill material has to retard radionuclides, to restrict the groundwater perlocation and to support mechanically the concrete structure of the repository silos. Mechanical and hydraulic behaviour of crushed tonalite when effected by stresses applied during compaction of the backfill and due to groundwater perlocation was studied at three batches having different gradations. Information about the phenomenon of settlement due to saturation and as a function of the compaction methods was obtained from a literature survey. The maximum amount of possible deformation due to compaction was analyzed with a gyratory device, known to have a good repeatability. In a group of simulation tests using a large oedometer cell the amount of compression due to the saturation process was measured. Also studies on the suitability of different compaction methods could be done with these tests. (43 refs., 49 figs., 3 tabs.)

Technics study on high accuracy crush dressing and sharpening of diamond grinding wheel

Science.gov (United States)

Jia, Yunhai; Lu, Xuejun; Li, Jiangang; Zhu, Lixin; Song, Yingjie

2011-05-01

Mechanical grinding of artificial diamond grinding wheel was traditional wheel dressing process. The rotate speed and infeed depth of tool wheel were main technics parameters. The suitable technics parameters of metals-bonded diamond grinding wheel and resin-bonded diamond grinding wheel high accuracy crush dressing were obtained by a mount of experiment in super-hard material wheel dressing grind machine and by analysis of grinding force. In the same time, the effect of machine sharpening and sprinkle granule sharpening was contrasted. These analyses and lots of experiments had extent instruction significance to artificial diamond grinding wheel accuracy crush dressing.

Geo-Engineering Evaluation of Rock Masses for Crushed Rock and Cut Stones in Khartoum State, Sudan

Science.gov (United States)

Kheirelseed, E. E.; Ming, T. H.; Abdalla, S. B.

The purpose of this study is to find artificial coarse aggregates and cut stones around Khartoum. To meat the objectives of the study, data from both field and laboratory are collected. The field data includes geological investigations based on different methods and samples collection, whereas the laboratory tests consists of specific gravity, water absorption, impact value, crushing value, Los Angeles abrasion, soundness tests. The field and laboratory results were weighed and compiled together to reveal the engineering performance of the different rock masses in term of cut stone and crushed aggregates. The results show that most of the examined rock masses are suitable for crushing, building and dressed stones. For decorative slabs only foliated granite and syenite masses can be used.

4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury.

Science.gov (United States)

Boyer, Richard B; Kelm, Nathaniel D; Riley, D Colton; Sexton, Kevin W; Pollins, Alonda C; Shack, R Bruce; Dortch, Richard D; Nanney, Lillian B; Does, Mark D; Thayer, Wesley P

2015-09-01

Diagnosis and management of peripheral nerve injury is complicated by the inability to assess microstructural features of injured nerve fibers via clinical examination and electrophysiology. Diffusion tensor imaging (DTI) has been shown to accurately detect nerve injury and regeneration in crush models of peripheral nerve injury, but no prior studies have been conducted on nerve transection, a surgical emergency that can lead to permanent weakness or paralysis. Acute sciatic nerve injuries were performed microsurgically to produce multiple grades of nerve transection in rats that were harvested 1 hour after surgery. High-resolution diffusion tensor images from ex vivo sciatic nerves were obtained using diffusion-weighted spin-echo acquisitions at 4.7 T. Fractional anisotropy was significantly reduced at the injury sites of transected rats compared with sham rats. Additionally, minor eigenvalues and radial diffusivity were profoundly elevated at all injury sites and were negatively correlated to the degree of injury. Diffusion tensor tractography showed discontinuities at all injury sites and significantly reduced continuous tract counts. These findings demonstrate that high-resolution DTI is a promising tool for acute diagnosis and grading of traumatic peripheral nerve injuries.

Recruitment of Intracavernously Injected Adipose-Derived Stem Cells to the Major Pelvic Ganglion Improves Erectile Function in a Rat Model of Cavernous Nerve Injury

Science.gov (United States)

Fandel, Thomas M.; Albersen, Maarten; Lin, Guiting; Qiu, Xuefeng; Ning, Hongxiu; Banie, Lia; Lue, Tom F.; Lin, Ching-Shwun

2011-01-01

Background Intracavernous (IC) injection of stem cells has been shown to ameliorate cavernous-nerve (CN) injury-induced erectile dysfunction (ED). However, the mechanisms of action of adipose-derived stem cells (ADSC) remain unclear. Objectives To investigate the mechanism of action and fate of IC injected ADSC in a rat model of CN crush injury. Design, setting, and participants Sprague-Dawley rats (n = 110) were randomly divided into five groups. Thirty-five rats underwent sham surgery and IC injection of ADSC (n = 25) or vehicle (n = 10). Another 75 rats underwent bilateral CN crush injury and were treated with vehicle or ADSC injected either IC or in the dorsal penile perineural space. At 1, 3, 7 (n = 5), and 28 d (n = 10) postsurgery, penile tissues and major pelvic ganglia (MPG) were harvested for histology. ADSC were labeled with 5-ethynyl-2-deoxyuridine (EdU) before treatment. Rats in the 28-d groups were examined for erectile function prior to tissue harvest. Measurements IC pressure recording on CN electrostimulation, immunohistochemistry of the penis and the MPG, and number of EdU-positive (EdU+) cells in the injection site and the MPG. Results and limitations IC, but not perineural, injection of ADSC resulted in significantly improved erectile function. Significantly more EdU+ ADSC appeared in the MPG of animals with CN injury and IC injection of ADSC compared with those injected perineurally and those in the sham group. One day after crush injury, stromal cell-derived factor-1 (SDF-1) was upregulated in the MPG, providing an incentive for ADSC recruitment toward the MPG. Neuroregeneration was observed in the group that underwent IC injection of ADSC, and IC ADSC treatment had beneficial effects on the smooth muscle/collagen ratio in the corpus cavernosum. Conclusions CN injury upregulates SDF-1 expression in the MPG and thereby attracts intracavernously injected ADSC. At the MPG, ADSC exert neuroregenerative effects on the cell bodies of injured nerves

Found in translation: understanding the biology and behavior of experimental traumatic brain injury

Science.gov (United States)

Bondi, Corina O.; Semple, Bridgette D.; Noble-Haeusslein, Linda J.; Osier, Nicole D.; Carlson, Shaun W.; Dixon, C. Edward; Giza, Christopher C.; Kline, Anthony E.

2014-01-01

BONDI, C.O., B.D. Semple, L.J. Noble-Haeusslein, N.D. Osier, S.W. Carlson, C.E. Dixon, C.C. Giza and A.E. Kline. Found in translation: understanding the biology and behavior of experimental traumatic brain injury. NEUROSCI BIOBEHAV REV. The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled “Traumatic brain injury: laboratory and clinical perspectives,” presented at the 2014 International Behavioral Neuroscience Society annual meeting. Herein we review contemporary laboratory models of traumatic brain injury (TBI) including common assays for sensorimotor and cognitive behavior. New modalities to evaluate social behavior after injury to the developing brain, as well as the attentional set-shifting test (AST) as a measure of executive function in TBI, will be highlighted. Environmental enrichment (EE) will be discussed as a preclinical model of neurorehabilitation, and finally, an evidence-based approach to sports-related concussion will be considered. The review consists predominantly of published data, but some discussion of ongoing or future directions is provided. PMID:25496906

Effect of moisture content on the flowability of crushed ores

Science.gov (United States)

Cabrejos, Francisco

2017-06-01

In many mining and industrial processes where large quantities of non-degrading bulk materials such as crushed ores are handled, silos, hoppers, stockpiles and chutes are widely used because they are economical and reliable (if properly designed and operated). However, they are not free of trouble and may experience flow problems such as arching, ratholing, erratic flow, limited storage capacity, limited discharge flow rate, caking, segregation and/or flooding. Moisture content and fine particles significantly affect the flowability of most ores, increasing their cohesive strength and turning them more prone to these problems. The purpose of this article is to highlight a proven, scientific method that can be utilized to ensure reliable storage, flow and discharge of bulk solids in these equipment based on Jenike's flow-of-solids theory and laboratory testing. Knowledge of the flow properties of the material handled provides a design basis to ensure mass flow, avoid arching and prevent the formation of "ratholes". The effect of an increase in water content of the ore is discussed with experimental results.

Effect of moisture content on the flowability of crushed ores

Directory of Open Access Journals (Sweden)

Cabrejos Francisco

2017-01-01

Full Text Available In many mining and industrial processes where large quantities of non-degrading bulk materials such as crushed ores are handled, silos, hoppers, stockpiles and chutes are widely used because they are economical and reliable (if properly designed and operated. However, they are not free of trouble and may experience flow problems such as arching, ratholing, erratic flow, limited storage capacity, limited discharge flow rate, caking, segregation and/or flooding. Moisture content and fine particles significantly affect the flowability of most ores, increasing their cohesive strength and turning them more prone to these problems. The purpose of this article is to highlight a proven, scientific method that can be utilized to ensure reliable storage, flow and discharge of bulk solids in these equipment based on Jenike’s flow-of-solids theory and laboratory testing. Knowledge of the flow properties of the material handled provides a design basis to ensure mass flow, avoid arching and prevent the formation of “ratholes”. The effect of an increase in water content of the ore is discussed with experimental results.

Recovery of salmonella serovar enteritidis from inoculated broiler hatching eggs using shell rinse and shell crush sampling methods

Science.gov (United States)

This study compared the recovery of Salmonella from hatching eggs using three sampling methods (eggshell rinsing, eggshell crush following a previous rinse, and eggshell crush without previous rinse). Eggshells were drop-inoculated with approximately 10, 100, or 1,000 cfu/eggshell of S. Enteritidis...

Estrogen Effects after a Crush Muscle Injury and Acute Exposure to Hypobaric Hypoxia

Science.gov (United States)

2015-03-01

inflammatory response to tissue injury. For example, in a rat trauma -hemorrhage model, estrogen attenuated splenic macrophage interleukin (IL)-6 and...strategy. For example, survival rate after combat trauma is now 91–99% [5]. Therefore, aeromedical evacuation is critical to the health and recovery... trauma -hemorrhage. J Cell Physiol. 2008; 214(3):662-672. 7. Miller AP, Feng W, Xing D, Weathington NM, Blalock JE, et al. Estrogen modulates

Fine-Needle Aspiration, Touch Imprint, and Crush Preparation Cytology for Diagnosing Thyroid Malignancies in Thyroid Nodules.

Science.gov (United States)

Ahmadinejad, Mojtaba; Aliepour, Asghar; Anbari, Khatereh; Kaviani, Mojhgan; Ganjizadeh, Hasan; Nadri, Sedigheh; Foroutani, Niloufar; Meysami, Masoumeh; Almasi, Vahid

2015-12-01

Several methods are used to evaluate the thyroid nodules. The aim of this study was to determine the sensitivity, specificity, false positive and negative rates, positive predictive value (PPV), and negative predictive value (NPV) of touch imprint, crush preparation, and fine-needle aspiration (FNA) methods. This cross-sectional study was done in Shohada-ye Ashayer University Hospital in Khorramabad. All the patients who underwent thyroid surgery due to thyroid nodules in this hospital between March and September 2011 were evaluated. The thyroid nodules of all the patients were evaluated by touch imprint, crush preparation, FNA, and permanent pathology methods. Finally, the results of the first three methods were compared with the result of permanent pathology method. The mean age of 104 patients who underwent thyroid surgery was 42.6 ± 11.9 years old. Based on permanent pathology, touch imprint, crush preparation, and FNA methods, 15.3, 6.25, 6.25, and 4.4 % of thyroid nodules were malignant, respectively. Sensitivity, specificity, false positive rate, false negative rate, PPV, and NPV of FNA biopsy were 62.5, 100, 0, 37.5, 100, and 95.3 %, respectively. Also, sensitivity, specificity, false positive rate, false negative rate, PPV, and NPV of touch imprint and crush preparation were equal and were 80, 100, 0, 20, 100, and 96.7 %, respectively. Using touch imprint and crush preparation in evaluation of thyroid nodules for rapid evaluation of these nodules in operating rooms seems to be logical, and it can prevent further surgeries.

Experimental study of pulmonary thromboembolism ischemia-reperfusion injury in canine model

International Nuclear Information System (INIS)

Li Jianjun; Zhai Renyou; Zhang Dongpo; Huang Qiang; Yu Ping; Dai Dingke; Bao Na

2009-01-01

Objective: To establish a canine model of pulmonary thromboembolism ischemia- reperfusion injury (PTE IRI) that may be used for imaging study. Methods: Ten male and 10 female healthy mongrel canines with (18.6±0.8) kg/body weight, were used. A Swan-Ganz catheter was introduced into the right internal jugular vein via a preset percutaneous sheath using the Seldinger technique, and then was with further insertion the pulmonary artery. Balloon occlusion of the right inferior lobe pulmonary artery for 4 hours was followed by removing the catheter and ending with 4 hours of reperfusion. CT was performed before ischemia, 4 h after ischemia and 4 h after reperfusion. At last, dogs were killed and the bilateral inferior lung tissues were prepared for the examination by light and electronic microscopy. Results: All canine models were successfully developed pulmonary thromboembolism ischemia-reperfusion injury. The examination of CT, light and electron microscopy consistently indicated the presence of permeability pulmonary edema after reperfusion. Conclusions: A closed-chest canine model in vivo of pulmonary thromboembolism ischemia-reperfusion injury can be established with virtual pathophysiological process in human and be as well as for imaging experimental study. (authors)

Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway.

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Yue, Rongzheng; Zuo, Chuan; Zeng, Jing; Su, Baihai; Tao, Ye; Huang, Songmin; Zeng, Rui

2017-11-01

To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism. Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvastatin groups. A rat model of contrast-induced acute kidney injury was established. We detected changes in serum creatinine (Scr) and blood urea nitrogen (BUN) before and after model establishment, observed and scored renal tubular injury, analyzed rat renal cell apoptosis, and measure the expression of signal pathway proteins and downstream inflammatory factors. After contrast agent injection, the Scr and BUN levels of the experimental control group were significantly increased, the different doses applied in the atorvastatin group significantly reduced the Scr and BUN levels (p atorvastatin doses have protective effects on contrast-induced acute renal tubular injury in rats, possibly by targeting TLR4, suppressing TLR4 expression, regulating the TLR4/Myd88 signaling pathway, and inhibiting the expression of downstream inflammatory factors.

Fracture of the acetabulum with femoral artery injury presenting late: A case report

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Sivaprasad Kalyanasundaram

2016-02-01

Full Text Available This study reports a rare case of both column acetabulum fracture with femoral artery injury that presented late and was managed with arterial reconstruction and fracture fixation.A thirty-one year old man sustained both column acetabular fracture on the left in a motor vehicle accident. On admission there was no obvious neuro-vascular deficit. During surgery for the fracture after 7 days of the injury the femoral artery was found to be severely crushed with no blood flow. The anterior column of the acetabulum was stabilised followed by resection and reconstruction of the femoral artery. The post-operative period was uneventful and he was discharged normally. At 6 months from injury the fractures had united well with excellent limb circulation and good lower limb function.Femoral artery injury with acetabular fracture is rare and late presentations are unreported hitherto. The results of fracture stabilisation and vessel reconstruction seem to be excellent. Literature of similar injuries is reviewed. Keywords: Acetabular fractures, Both column fractures, Anterior column fractures, Vascular injury, Femoral artery injury

Transient convergence and compaction of crushed salt as incorporated in the computer code EMOS

International Nuclear Information System (INIS)

Heijdra, J.J.; Hamilton, L.F.M.; Prij, J.; Slagter, W.

1995-11-01

An improved model for description of the transient convergence of cavities in rock salt, together with an improved model for the compaction of crushed salt is introduced. The covergence model is based on solutions of the analytical expressions based on secondary creep for a cylindrical and spherical cavity in rock salt. For the model for compaction of crushed salt the relations based on theoretical micro mechanisms have been fitted to laboratory results. A description is given of how the improved models are incorporated into the program EMOS. (orig.)

Transient convergence and compaction of crushed salt as incorporated in the computer code EMOS

Energy Technology Data Exchange (ETDEWEB)

Heijdra, J.J.; Hamilton, L.F.M.; Prij, J.; Slagter, W.

1995-11-01

An improved model for description of the transient convergence of cavities in rock salt, together with an improved model for the compaction of crushed salt is introduced. The covergence model is based on solutions of the analytical expressions based on secondary creep for a cylindrical and spherical cavity in rock salt. For the model for compaction of crushed salt the relations based on theoretical micro mechanisms have been fitted to laboratory results. A description is given of how the improved models are incorporated into the program EMOS. (orig.).

(--Epigallocatechin gallate attenuates NADPH-d/nNOS expression in motor neurons of rats following peripheral nerve injury

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Tseng Chi-Yu

2011-06-01

Full Text Available Abstract Background Oxidative stress and large amounts of nitric oxide (NO have been implicated in the pathophysiology of neuronal injury and neurodegenerative disease. Recent studies have shown that (--epigallocatechin gallate (EGCG, one of the green tea polyphenols, has potent antioxidant effects against free radical-mediated lipid peroxidation in ischemia-induced neuronal damage. The purpose of this study was to examine whether EGCG would attenuate neuronal expression of NADPH-d/nNOS in the motor neurons of the lower brainstem following peripheral nerve crush. Thus, young adult rats were treated with EGCG (10, 25, or 50 mg/kg, i.p. 30 min prior to crushing their hypoglossal and vagus nerves for 30 seconds (left side, at the cervical level. The treatment (pre-crush doses of EGCG was continued from day 1 to day 6, and the animals were sacrificed on days 3, 7, 14 and 28. Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d histochemistry and neuronal nitric oxide synthase (nNOS immunohistochemistry were used to assess neuronal NADPH-d/nNOS expression in the hypoglossal nucleus and dorsal motor nucleus of the vagus. Results In rats treated with high dosages of EGCG (25 or 50 mg/kg, NADPH-d/nNOS reactivity and cell death of the motor neurons were significantly decreased. Conclusions The present evidence indicated that EGCG can reduce NADPH-d/nNOS reactivity and thus may enhance motor neuron survival time following peripheral nerve injury.

Unusual presentation of firework injury causing intraoral burns

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Patel Chintan

2005-01-01

Full Text Available Fireworks are commonly used in celebrate festive occasions. We present a case of an unusual presentation of intraoral firework injury, which is a very rare case. A fifteen year old boy kept four explosive papercaps wrapped in a small polythene bags in between his left molars and crushed them. This resulted in a contused lacerated wound over the left buccal mucosa. Patient was treated conservatively with maintenance of intraoral hygiene, antibiotics, proteolytic enzymes and analgesics. It took 18 days for complete healing of the wound.

Thoracic Injuries in earthquake-related versus non-earthquake-related trauma patients: differentiation via Multi-detector Computed Tomography

Science.gov (United States)

Dong, Zhi-hui; Yang, Zhi-gang; Chen, Tian-wu; Chu, Zhi-gang; Deng, Wen; Shao, Heng

2011-01-01

PURPOSE: Massive earthquakes are harmful to humankind. This study of a historical cohort aimed to investigate the difference between earthquake-related crush thoracic traumas and thoracic traumas unrelated to earthquakes using a multi-detector Computed Tomography (CT). METHODS: We retrospectively compared an earthquake-exposed cohort of 215 thoracic trauma crush victims of the Sichuan earthquake to a cohort of 215 non-earthquake-related thoracic trauma patients, focusing on the lesions and coexisting injuries to the thoracic cage and the pulmonary parenchyma and pleura using a multi-detector CT. RESULTS: The incidence of rib fracture was elevated in the earthquake-exposed cohort (143 vs. 66 patients in the non-earthquake-exposed cohort, Risk Ratio (RR) = 2.2; pchest (45/143 vs. 11/66 patients, RR = 1.9; ptraumas resulting from the earthquake were life threatening with a high incidence of bony thoracic fractures. The ribs were frequently involved in bilateral and severe types of fractures, which were accompanied by non-rib fractures, pulmonary parenchymal and pleural injuries. PMID:21789386

Experimental studies on the injurious effect of sulfur dioxide upon the rice cultivation

Energy Technology Data Exchange (ETDEWEB)

Teshima, T; Takahashi, T

1952-01-01

From experimental studies on the injurious effect of sulfur dioxide upon the cultivation of rice it was ascertained that SO2 strongly affects the pollen and the ovary. The pollen and the matured grain showed a decrease in fertility when the plant is fumigated at the flowering and boot stage.

Modeling of the endosperm crush response profile of hard red spring wheat using a single kernel characterization system

Science.gov (United States)

When a wheat endosperm is crushed the force profile shows viscoelastic response and the modulus of elasticity is an important parameter that might have substantial influence on wheat milling. An experiment was performed to model endosperm crush response profile (ECRP) and to determine the modulus o...

J. Crush and D.A. McDonald. (eds). 2002. Transnationalism and ...

African Journals Online (AJOL)

J. Crush and D.A. McDonald. (eds). 2002. Transnationalism and New African Immigration to South Africa. Cape Town. Southern African Migration Project and the Canadian Association of African Studies. IV + 188 pp. ISBN 0-88911-926-0.

Development of a system for receiving, crushing and screening recycled fuel (REF) material; Kierraetyspolttoaineen vastaanotto-, murskaus- ja seulontajaerjestelmaen kehittaeminen

Energy Technology Data Exchange (ETDEWEB)

Nurmi, A [VTT Energy, Jyvaeskylae (Finland)

1997-12-01

The goal of this project is to develop a system to which source sorted combustible industrial, office and municipal waste material can be taken and where it is then processed in such way that it can be burnt in modern fluidized bed and circulating bed boilers. The project started in the end of year 1995. The main stages of the project are: (1) Study and analysis of existing technology and equipment, (2) Development of system components, (3) Development of the system, (4) Building a pilot/demonstration plant, (5) Tests and results analysis and (6) Decisions on further actions. In the year 1996 the main stage was development of system components; especially crushing. Results of running slow-speed big crushers were collected, analysed and the main development details determined. Additionally, particle size distribution from different crushing methods were analyzed using also primary and secondary crushing. Development of a heavy-duty 2-rotor ECO-Crusher and a crushing screen was started. Regarding to the development of the REF-system, different alternatives have been analyzed and possible demonstration places have been searched. The first multi-crushing line will be demonstrated in Sweden. (orig.)

Effect of Crushed Sandstone Sand on the Properties of High ...

African Journals Online (AJOL)

This paper presents results of the laboratory investigation on high performance concrete (HPC) using crushed sandstone sand as 20%, 40%, and 60% replacement of river sand together with superplastisizer and silica fume (SF). The fresh concrete properties such as slump, air content and fresh concrete density have been ...

Compartment and Crush Syndromes After Sleep Deprivation and a Therapeutic Dose of Zolpidem

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Martin R. Huecker

2017-07-01

Full Text Available Despite extensive review in the literature, compartment syndrome and crush syndrome remain difficult to diagnose. Trauma, toxins and reperfusion have been associated with these syndromes. Cases involving alcohol and drug abuse have described patients “found down” compressing an extremity. We present a case of a registered nurse who developed compartment syndrome in multiple limbs due to prolonged sleep after sleep deprivation and zolpidem use. To our knowledge, this is the first case of compartment syndrome or crush syndrome to have occurred in the setting of zolpidem use. Sleep disruption in healthcare workers represents a public health issue with dangerous sequelae, both acute and chronic.

Sealing performance assessments of bentonite and bentonite/crushed rock plugs

International Nuclear Information System (INIS)

Ouyang, Shoung.

1990-01-01

Bentonite and mixtures of bentonite and crushed rock are potential sealing materials for high level nuclear waste repositories. The materials have been used to form cap layers to reduce infiltration for mined waste tailings and can also be used to construct clay liners for municipal as well as industrial waste managements. American Colloid C/S granular dentonite and Apache Leap tuff have been mixed to prepare samples for laboratory flow testing. Bentonite weight percent and crushed tuff gradation are the major variables studied. The sealing performance assessments include high injection pressure flow tests, polyaxial flow tests, high temperature flow tests, and piping tests. The results indicate that an appropriate composition would have at least 25% bentonite by weight mixed with well-graded crushed rock. Hydraulic properties of the mixture plugs may be highly anisotropic if significant particle segregation occurs during sample installation and compaction. Temperature has no negative effects on the sealing performance within the test range from room temperature to 60C. The piping damage to the sealing performance is small if the maximum hydraulic gradient does not exceed 120 and 280 for 25 and 35% bentonite content, respectively. The hydraulic gradients above which flow of bentonite may take place are deemed critical. Analytical work includes the introduction of bentonite occupancy percentage and water content at saturation as two major parameters for the plug design. A permeability model developed is useful for the prediction of permeability in clays. A piping model permits the estimation of critical hydraulic gradient allowed before the flow of bentonite takes place. It can also be used to define the maximum allowable pore diameter of a protective filter layer

Sustainable normal and high strength recycled aggregate concretes using crushed tested cylinders as coarse aggregates

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Bilal S. Hamad

2017-12-01

Full Text Available The paper reports on a research program that was designed at the American University of Beirut (AUB to investigate the fresh and hardened mechanical properties of a high performance concrete mix produced with partial or full substitution of crushed natural lime-stone aggregates with recycled aggregates from crushed tested cylinders in batching plants. Choosing crushed cylinders as source of recycling would result in reusing portion of the waste products of the concrete production industry. An extensive concrete batching and testing program was conducted to achieve two optimum normal and high strength concrete mixes. The variables were the nominal concrete strength (28 or 60 MPa and the percentage replacement of natural coarse aggregates with recycled aggregates from crushed tested cylinders (0, 20, 40, 60, 80, or 100%. Normal strength tested cylinders were used as source of the recycled aggregates for the normal strength concrete (NSC mix and high strength tested cylinders were used for the high strength concrete (HSC mix. Tests on the trial batches included plastic state slump and hardened state mechanical properties including cylinder compressive strength, cylinder splitting tensile strength, modulus of elasticity, and standard beams flexural strength. The results indicated no significant effect on the slump and around 10% average reduction in the hardened mechanical properties for both investigated levels of concrete compressive strength.

Intravenous mesenchymal stem cell therapy after recurrent laryngeal nerve injury: a preliminary study.

Science.gov (United States)

Lerner, Michael Z; Matsushita, Takashi; Lankford, Karen L; Radtke, Christine; Kocsis, Jeffery D; Young, Nwanmegha O

2014-11-01

Intravenous administration of mesenchymal stem cells (MSCs) has been recently shown to enhance functional recovery after stroke and spinal cord injury. The therapeutic properties of MSCs are attributed to their secretion of a variety of potent antiinflammatory and neurotrophic factors. We hypothesize that intravenous administration of MSCs after recurrent laryngeal nerve (RLN) injury in the rat may enhance functional recovery. Animal Research. Twelve 250-gram Sprague-Dawley rats underwent a controlled crush injury to the left RLN. After confirming postoperative vocal fold immobility, each rat was intravenously infused with either green fluorescent protein-expressing MSCs or control media in a randomized and blinded fashion. Videolaryngoscopy was performed weekly. The laryngoscopy video recordings were reviewed and rated by a fellowship-trained laryngologist who remained blinded to the intervention using a 0 to 3 scale. At 1 week postinjury, the MSC-infused group showed a trend for higher average functional recovery scores compared to the control group (2.2 vs 1.3), but it did not reach statistical significance (P value of 0.06). By 2 weeks, however, both groups exhibited complete return of function. These pilot data indicate that with complete nerve transection by crush injury of the RLN in rat, there is complete recovery of vocal fold mobility at 2 weeks. At 1 week postinjury, animals receiving intravenous infusion of MSCs showed a trend for greater functional recovery, suggesting a potential beneficial effect of MSCs; however, this did not reach statistical significance. Therefore, no definite conclusions can be drawn from these data and further study is required. N/A. © 2014 The American Laryngological, Rhinological and Otological Society, Inc.

Reduction of Biomass Moisture by Crushing/Splitting - A Concept

Science.gov (United States)

Paul E. Barnett; Donald L. Sirois; Colin Ashmore

1986-01-01

A biomass crusher/splitter concept is presented as a possible n&ant of tsafntainfng rights-of-way (ROW) or harvesting energy wood plantations. The conceptual system would cut, crush, and split small woody biomass leaving it in windrows for drying. A subsequent operation would bale and transport the dried material for use as an energy source. A survey of twenty...

Comparison of ice particle morphology crushed from ice chunk and directly solidified from droplet

Energy Technology Data Exchange (ETDEWEB)

Yang, J.H.; Yoon, Y.S.; Bang, S.Y. [Dongguk Univ., Pil-dong, Chung-gu, Seoul (Korea, Republic of). Dept. of Mechanical Engineering

2008-07-01

In order to investigate the transition kinetics of ice to hydrate and to produce standard specimens of hydrate pellet from prepared hydrate powders, fine ice beads with uniform diameters must be fabricated. This paper discussed the construction of several experimental setups for the fabrication of fine ice particle generation. The ultrasonic nozzle was used to produce fine mist which solidified near the free surface of liquid nitrogen bath. The shape and population distribution of ice bead diameters was analyzed. The study also compared ice particles produced by crushing. The surface morphology of ice particles produced with a ball mill was also examined. Experimental results were obtained for an ice shaver, ball mill, bowl for grinding medicine, and ultrasonic nozzle. It was concluded that the information generated from the study was useful in estimating the macroscopic flow characteristics such as permeability of bulk powder and in determining mean effective diameter of irregular shaped particles. Future work was also noted as being underway with different experiments for other cases with different operating conditions. 5 refs., 5 figs.

Double Kissing Crush Versus Provisional Stenting for Left Main Distal Bifurcation Lesions: DKCRUSH-V Randomized Trial.

Science.gov (United States)

Chen, Shao-Liang; Zhang, Jue-Jie; Han, Yaling; Kan, Jing; Chen, Lianglong; Qiu, Chunguang; Jiang, Tiemin; Tao, Ling; Zeng, Hesong; Li, Li; Xia, Yong; Gao, Chuanyu; Santoso, Teguh; Paiboon, Chootopol; Wang, Yan; Kwan, Tak W; Ye, Fei; Tian, Nailiang; Liu, Zhizhong; Lin, Song; Lu, Chengzhi; Wen, Shangyu; Hong, Lang; Zhang, Qi; Sheiban, Imad; Xu, Yawei; Wang, Lefeng; Rab, Tanveer S; Li, Zhanquan; Cheng, Guanchang; Cui, Lianqun; Leon, Martin B; Stone, Gregg W

2017-11-28

Provisional stenting (PS) is the most common technique used to treat distal left main (LM) bifurcation lesions in patients with unprotected LM coronary artery disease undergoing percutaneous coronary intervention. The double kissing (DK) crush planned 2-stent technique has been shown to improve clinical outcomes in non-LM bifurcations compared with PS, and in LM bifurcations compared with culotte stenting, but has never been compared with PS in LM bifurcation lesions. The authors sought to determine whether a planned DK crush 2-stent technique is superior to PS for patients with true distal LM bifurcation lesions. The authors randomized 482 patients from 26 centers in 5 countries with true distal LM bifurcation lesions (Medina 1,1,1 or 0,1,1) to PS (n = 242) or DK crush stenting (n = 240). The primary endpoint was the 1-year composite rate of target lesion failure (TLF): cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularization. Routine 13-month angiographic follow-up was scheduled after ascertainment of the primary endpoint. TLF within 1 year occurred in 26 patients (10.7%) assigned to PS, and in 12 patients (5.0%) assigned to DK crush (hazard ratio: 0.42; 95% confidence interval: 0.21 to 0.85; p = 0.02). Compared with PS, DK crush also resulted in lower rates of target vessel myocardial infarction I (2.9% vs. 0.4%; p = 0.03) and definite or probable stent thrombosis (3.3% vs. 0.4%; p = 0.02). Clinically driven target lesion revascularization (7.9% vs. 3.8%; p = 0.06) and angiographic restenosis within the LM complex (14.6% vs. 7.1%; p = 0.10) also tended to be less frequent with DK crush compared with PS. There was no significant difference in cardiac death between the groups. In the present multicenter randomized trial, percutaneous coronary intervention of true distal LM bifurcation lesions using a planned DK crush 2-stent strategy resulted in a lower rate of TLF at 1 year than a PS�

Thyroid hormones regulate skeletal muscle regeneration after acute injury.

Science.gov (United States)

Leal, Anna Lúcia R C; Albuquerque, João Paulo C; Matos, Marina S; Fortunato, Rodrigo S; Carvalho, Denise P; Rosenthal, Doris; da Costa, Vânia Maria Corrêa

2015-02-01

We evaluated the effects of hypo- and hyperthyroid statuses during the initial phase of skeletal muscle regeneration in rats. To induce hypo- or hyperthyroidism, adult male Wistar rats were treated with methimazole (0.03%) or T4 (10 μg/100 g), respectively, for 10 days. Three days before sacrifice, a crush injury was produced in the solear muscles of one half of the animals, while the other half remained intact. T3, T4, TSH, and leptin serum levels were not affected by the injury. Serum T3 and T4 levels were significantly increased in hyperthyroid and hyper-injury animals. Hypothyroidism was confirmed by the significant increase in serum TSH levels in hypothyroid and hypo-injury animals. Injury increased cell infiltration and macrophage accumulation especially in hyperthyroid animals. Both type 2 and type 3 deiodinases were induced by lesion, and the opposite occurred with the type 1 isoform, at least in the control and hyperthyroid groups. Injury increased both MyoD and myogenin expression in all the studied groups, but only MyoD expression was increased by thyroidal status only at the protein level. We conclude that thyroid hormones modulate skeletal muscle regeneration possibly by regulating the inflammatory process, as well as MyoD and myogenin expression in the injured tissue.

Ball mill tool for crushing coffee and cocoa beans base on fraction size sieving results

Science.gov (United States)

Haryanto, B.; Sirait, M.; Azalea, M.; Alvin; Cahyani, S. E.

2018-02-01

Crushing is one of the operation units that aimed to convert the size of solid material to be smoother particle’s size. The operation unit that can be used in this crushing is ball mill. The purpose of this study is to foresee the effect of raw material mass, grinding time, and the number of balls that are used in the ball mill tool related to the amount of raw material of coffee and cocoa beans. Solid material that has become smooth is then sieved with sieve mesh with size number: 50, 70, 100, and 140. It is in order to obtain the mass fraction that escaped from each sieve mesh. From the experiment, it can be concluded that mass percentage fraction of coffee powder is bigger than cocoa powder that escaped from the mesh. Hardness and humidity of coffee beans and cocoa beans have been the important factors that made coffee beans is easier to be crushed than cocoa beans.

The classification of wood chips parameters by crushing of waste cane from different varieties of grapevine

Directory of Open Access Journals (Sweden)

Patrik Burg

2008-01-01

Full Text Available This work deales with exploitatives parameters monitoring of wood shreder PEZZOLATO 110 Mb by crushing of waste cane of six varieties. The results shows that the wood shreders efficiency, fuel consumption and the wood chips elements size can be influenced by varieties characters of cane. The va­lued machines efficiency was 230–470 kg . h−1 by average volume 40.70 % water in wood. The hig­hest values by cane crushing had the variety Saint Laurent (0.47 t . h−1 and the lowest variety ­Blauer Portugieser (0.23 t . h−1. The specific consumption of petrol Natural 95 was 4.52.10−3–8.12.10−3 l . kg−1. The average middle elements lenght was 6.64 mm by crushed varieties.

[Fatal incidents by crowd crush during mass events. (Un)preventable phenomenon?].

Science.gov (United States)

Wagner, U; Fälker, A; Wenzel, V

2013-01-01

Crowd crushes with dozens or even hundreds of casualties have occurred several times at the Hajj in Saudi Arabia and also in soccer stadiums in Western Europe. As fatal accidents after human stampedes during mass events occur very rarely and are usually accompanied by many years of criminal court proceedings in order to identify underlying responsible mechanisms and culprits, it is very difficult to draw conclusions and formulate precautions from an emergency medical point of view. This study analyzed a fatal crowd crush which occurred on 4 December 1999 following the "Air & Style" snowboard contest with approximately 22,000 people attending in the Bergisel stadium in Innsbruck, Austria. Firstly, focused interviews were conducted with professional rescuers, police and physicians and secondly publicly available court records dealing with this incident in the district court of Innsbruck, Austria were analyzed. During the snowboard contest 87 emergency medical technicians, 6 emergency physicians, 1 leading emergency physician, 21 policemen and 140 security personnel were present. Following the accident additionally some 100 emergency medical technicians, 36 emergency medical service vehicles and 4 physician-staffed emergency medical service vehicles responded to the scene. The deadly crowd crush resulting in 6 fatalities, 4 patients still in a vegetative state and 38 injured, was due to a severe crowd accumulation at one stadium exit, which was not recognized and dispersed in time. Construction of the exit in line with darkness, steep slope and slippery surface contributed adversely to this dangerous situation, although panic did not occur at any time. Unfortunately, there is no patent remedy to completely prevent fatal accidents by a crowd crush at mass events. If planning is initiated early, sufficient material and personnel reserves are kept in reserve and despite conflicting interests of the organizers, the host community, security, police and emergency medical

Mitigating the Health Risks of Stone Quarrying and Crushing in India ...

International Development Research Centre (IDRC) Digital Library (Canada)

In Pratapura Industrial Area (Tikamgarh district, Bundelkhand region, Madhya ... In the context of weak regulatory enforcement, worksite health and safety ... in stone quarrying and crushing through better ecosystem management. ... India, Central Asia, Far East Asia, South Asia ... LVIF announces five more funded projects.

Remaining porosity and permeability of compacted crushed rock salt backfill in a HLW repository. Final report

Energy Technology Data Exchange (ETDEWEB)

Jobmann, M.; Mueller, C.; Schirmer, S.

2015-11-15

The safe containment of radioactive waste is to be ensured by the geotechnical barriers in combination with the containment-providing rock zone (CRZ). The latter is a key element of the recently developed concept of demonstrating the integrity of the geologic barrier (Krone et al., 2013). As stipulated in the safety requirements of the regulating body the CRZ has to have strong barrier properties, and evidence needs to be provided that it retains its integrity throughout the reference period (BMU, 2010). The underground openings excavated in the rock salt will close over time due to the creep properties of the rock salt. This process causes deformations in the surrounding rock salt, which leads to a change in stress state in the virgin rock and may impair the integrity of the containment-providing rock zone. In order to limit the effects of these processes, all underground openings will be backfilled with crushed salt. Immediately after backfilling, the crushed salt will have an initial porosity of approx. 35%, which - over time - will be reduced to very low values due to the creep properties of the rock salt. The supporting pressure that builds up in the crushed salt with increasing compaction slows down the creeping of the salt. Major influencing factors are the temperature (with higher temperatures accelerating the salt creeping) and the moisture of the salt, which - due to the related decrease in the resistance of the crushed salt - facilitates its compaction. The phenomenology of these processes and dependencies is understood to a wide extent. This project investigated the duration until compaction is completed and when and under what circumstances the crushed salt will have the sealing properties necessary to ensure safe containment. Thermo-hydro-mechanical (THM) processes play a crucial role in determining whether solutions which might enter the mine could reach the radioactive waste. This includes changes in material behaviour due to a partial or complete

The role of Facebook in Crush the Crave, a mobile- and social media-based smoking cessation intervention: qualitative framework analysis of posts.

Science.gov (United States)

Struik, Laura Louise; Baskerville, Neill Bruce

2014-07-11

Social networking sites, particularly Facebook, are increasingly included in contemporary smoking cessation interventions directed toward young adults. Little is known about the role of Facebook in smoking cessation interventions directed toward this age demographic. The aim of this study was to characterize the content of posts on the Facebook page of Crush the Crave, an evidence-informed smoking cessation intervention directed toward young adults aged 19 to 29 years. Crush the Crave Facebook posts between October 10, 2012 and June 12, 2013 were collected for analysis, representing page activity during the pilot phase of Crush the Crave. Of the 399 posts included for analysis, 121 were original posts, whereas the remaining 278 were reply posts. Posts were coded according to themes using framework analysis. We found that the original Crush the Crave Facebook posts served two main purposes: to support smoking cessation and to market Crush the Crave. Most of the original posts (86/121, 71.1%) conveyed support of smoking cessation through the following 7 subthemes: encouraging cessation, group stimulation, management of cravings, promoting social support, denormalizing smoking, providing health information, and exposing tobacco industry tactics. The remaining original posts (35/121, 28.9%) aimed to market Crush the Crave through 2 subthemes: Crush the Crave promotion and iPhone 5 contest promotion. Most of the reply posts (214/278, 77.0%) were in response to the supporting smoking cessation posts and the remaining 64 (23.0%) were in response to the marketing Crush the Crave posts. The most common response to both the supporting smoking cessation and marketing Crush the Crave posts was user engagement with the images associated with each post at 40.2% (86/214) and 45% (29/64), respectively. The second most common response consisted of users sharing their smoking-related experiences. More users shared their smoking-related experiences in response to the supporting

Mitigating the Health Risks of Stone Quarrying and Crushing in India ...

International Development Research Centre (IDRC) Digital Library (Canada)

In Pratapura Industrial Area (Tikamgarh district, Bundelkhand region, Madhya Pradesh), stone quarrying and crushing is carried out by labor-intensive units employing unskilled workers on a seasonal basis complementing the agricultural cycle. In the context of weak regulatory enforcement, worksite health and safety ...

Crushing leads to waste disposal savings for FUSRAP

Energy Technology Data Exchange (ETDEWEB)

Darby, J. [Department of Energy, Oak Ridge, TN (United States)

1997-02-01

In this article the author discusses the application of a rock crusher as a means of implementing cost savings in the remediation of FUSRAP sites. Transportation and offsite disposal costs are at present the biggest cost items in the remediation of FUSRAP sites. If these debris disposal problems can be handled in different manners, then remediation savings are available. Crushing can result in the ability to handle some wastes as soil disposal problems, which have different disposal regulations, thereby permitting cost savings.

Rapid detection of toxic metals in non-crushed oyster shells by portable X-ray fluorescence spectrometry

Energy Technology Data Exchange (ETDEWEB)

Chou Ju, E-mail: Ju.Chou@selu.ed [Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, LA 70402 (United States); Clement, Garret; Bursavich, Bradley; Elbers, Don [Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, LA 70402 (United States); Cao Baobao; Zhou Weilie [Advanced Material Research Institute, University of New Orleans, New Orleans, LA 70148 (United States)

2010-06-15

The aim of this study was the multi-elemental detection of toxic metals such as lead (Pb) in non-crushed oyster shells by using a portable X-ray fluorescence (XRF) spectrometer. A rapid, simultaneous multi-element analytical methodology for non-crushed oyster shells has been developed using a portable XRF which provides a quick, quantitative, non-destructive, and cost-effective mean for assessment of oyster shell contamination from Pb. Pb contamination in oyster shells was further confirmed by scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS). The results indicated that Pb is distributed in-homogeneously in contaminated shells. Oyster shells have a lamellar structure that could contribute to the high accumulation of Pb on oyster shells. - A rapid, simultaneous multi-element analytical methodology for non-crushed oyster shells has been developed using XRF and contamination of lead on oyster shells was confirmed by XRF and SEM-EDS.

Rapid detection of toxic metals in non-crushed oyster shells by portable X-ray fluorescence spectrometry

International Nuclear Information System (INIS)

Chou Ju; Clement, Garret; Bursavich, Bradley; Elbers, Don; Cao Baobao; Zhou Weilie

2010-01-01

The aim of this study was the multi-elemental detection of toxic metals such as lead (Pb) in non-crushed oyster shells by using a portable X-ray fluorescence (XRF) spectrometer. A rapid, simultaneous multi-element analytical methodology for non-crushed oyster shells has been developed using a portable XRF which provides a quick, quantitative, non-destructive, and cost-effective mean for assessment of oyster shell contamination from Pb. Pb contamination in oyster shells was further confirmed by scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS). The results indicated that Pb is distributed in-homogeneously in contaminated shells. Oyster shells have a lamellar structure that could contribute to the high accumulation of Pb on oyster shells. - A rapid, simultaneous multi-element analytical methodology for non-crushed oyster shells has been developed using XRF and contamination of lead on oyster shells was confirmed by XRF and SEM-EDS.

Exploratory study of crushed coconut shell as partial replacement for ...

African Journals Online (AJOL)

The trend shows a decrease in strength as the quantity of CCS in the concrete cubes increases. The workability of the concrete decreased as the quantity of CSS increased with the mould slumping at 100% CSS. Aggregate Crushing Value (ACV) for CSS is 8% and that for fine sand is 17.89%,, while Aggregate Impact ...

On the crush behavior of an ultra light multi-cell foam-filled composite structures for energy absorption: Part 2-Numerical simulation

International Nuclear Information System (INIS)

Taher, Siavash T.; Rizal Zahari; Faizal Mustapha; Ataollahi, Simin

2010-01-01

The present paper is dealing with the implementation of the finite element explicit dynamic analysis code module incorporated ANSYS/ LS-DYNA computer software to the simulation of the crash behavior and energy adsorption characteristics of a novel multi-cell cost-effective crash worthy composite sandwich structure. In a previous paper, the authors developed the concept of the triple-layered foam-filled block and submitted experimental results of the crash behaviour and crash worthiness characteristics of such structure. The obtained numerical results of axial compression model of composite blocks are compared with actual experimental data of crash energy adsorption, load-displacement history and crush zone characteristics, showing very good agreement. Theoretical and experimental results showed good similarities in peak load, average load and energy absorption with and without use of two types of collapse trigger mechanism. (author)

Crushing Candy: The Free-to-Play Game in Its Connective Commodity Form

Directory of Open Access Journals (Sweden)

David B. Nieborg

2015-12-01

Full Text Available The goal of this article is to add a complementary perspective to the study of social network sites by surveying how the political economy of social media platforms relates to the structure of free-to-play games in their commodity form. Drawing on the theory of multisided markets and critical political economy, this article surveys the political economy of game apps and investigates how it is symbiotically related to the technological and economic logic underlying connective platforms operated by Google, Apple, Facebook, and Amazon. These social media platforms operate app stores that sustain the transformation of games as fixed, physically distributed products that follow a transaction logic, into digitally distributed, freely accessible, or “free-to-play” apps. Through a case study of the popular casual game Candy Crush Saga it is contended that the connective properties of social media platforms affect the form and format of game apps as cultural commodities. Candy Crush Saga developer King Digital Entertainment has been able to attract hundreds of millions of players and build a business model that combines the commodification of virtual items, connectivity, user attention, user data, and play. It is argued that the free-to-play commodity form comprises three commodity types: the product commodity, the “prosumer commodity,” and the player commodity. Furthermore, Candy Crush Saga ’s commodity form is structured by a platformed modality of cultural production and circulation and therefore embedded in the political economy of its host platform.

Reducing the startup time of aerobic granular sludge reactors through seeding floccular sludge with crushed aerobic granules.

Science.gov (United States)

Pijuan, Maite; Werner, Ursula; Yuan, Zhiguo

2011-10-15

One of the main challenging issues for the aerobic granular sludge technology is the long startup time when dealing with real wastewaters. This study presents a novel strategy to reduce the time required for granulation while ensuring a high level of nutrient removal. This new approach consists of seeding the reactor with a mixture of crushed aerobic granules and floccular sludge. The effectiveness of the strategy was demonstrated using abattoir wastewater, containing nitrogen and phosphorus at approximately 250 mgN/L and 30 mgP/L, respectively. Seven different mixtures of crushed granules and floccular sludge at granular sludge fractions (w/w in dry mass) of 0%, 5%, 10%, 15%, 25%, 30% and 50% were used to start eight granulation processes. The granulation time (defined as the time when the 10th percentile bacterial aggregate size is larger than 200 μm) displayed a strong dependency on the fraction of granular sludge. The shortest granulation time of 18 days was obtained with 50% crushed granules, in comparison with 133 days with 5% crushed granules. Full granulation was not achieved in the two trials without seeding with crushed granules. In contrast to the 100% floccular sludge cases, where a substantial loss of biomass occurred during granulation, the biomass concentration in all other trails did not decrease during granulation. This allowed that good nitrogen removal was maintained in all the reactors during the granulation process. However, enhanced biological phosphorus removal was achieved in only one of the eight trials. This was likely due to the temporary accumulation of nitrite, a strong inhibitor of polyphosphate accumulating organisms. Copyright © 2011 Elsevier Ltd. All rights reserved.

Mitigating the Health Risks of Stone Quarrying and Crushing in India ...

International Development Research Centre (IDRC) Digital Library (Canada)

In Pratapura Industrial Area (Tikamgarh district, Bundelkhand region, Madhya ... In the context of weak regulatory enforcement, worksite health and safety measures are not ... involved in stone quarrying and crushing through better ecosystem management. ... et les défis futurs dans la communauté économique de l'ASEAN.

Cerebrospinal fluid pressures resulting from experimental traumatic spinal cord injuries in a pig model.

Science.gov (United States)

Jones, Claire F; Lee, Jae H T; Burstyn, Uri; Okon, Elena B; Kwon, Brian K; Cripton, Peter A

2013-10-01

Despite considerable effort over the last four decades, research has failed to translate into consistently effective treatment options for spinal cord injury (SCI). This is partly attributed to differences between the injury response of humans and rodent models. Some of this difference could be because the cerebrospinal fluid (CSF) layer of the human spine is relatively large, while that of the rodents is extremely thin. We sought to characterize the fluid impulse induced in the CSF by experimental SCIs of moderate and high human-like severity, and to compare this with previous studies in which fluid impulse has been associated with neural tissue injury. We used a new in vivo pig model (n = 6 per injury group, mean age 124.5 days, 20.9 kg) incorporating four miniature pressure transducers that were implanted in pairs in the subarachnoid space, cranial, and caudal to the injury at 30 mm and 100 mm. Tissue sparing was assessed with Eriochrome Cyanine and Neutral Red staining. The median peak pressures near the injury were 522.5 and 868.8 mmHg (range 96.7-1430.0) and far from the injury were 7.6 and 36.3 mmHg (range 3.8-83.7), for the moderate and high injury severities, respectively. Pressure impulse (mmHg.ms), apparent wave speed, and apparent attenuation factor were also evaluated. The data indicates that the fluid pressure wave may be sufficient to affect the severity and extent of primary tissue damage close to the injury site. However, the CSF pressure was close to normal physiologic values at 100 mm from the injury. The high injury severity animals had less tissue sparing than the moderate injury severity animals; this difference was statistically significant only within 1.6 mm of the epicenter. These results indicate that future research seeking to elucidate the mechanical origins of primary tissue damage in SCI should consider the effects of CSF. This pig model provides advantages for basic and preclinical SCI research due to its

Interim design report: fuel particle crushing

International Nuclear Information System (INIS)

Baer, J.W.; Strand, J.B.; Cook, E.J.; Miller, C.M.

1977-11-01

The double-roll fuel particle crusher was developed to fracture the silicon carbide coatings of Fort St. Vrain (FSV) fertile and fissile and large high-temperature gas-cooled reactor (LHTGR) fissile fuel particles. The report details the design task for the fuel particle crusher, including historical test information on double-roll crushers for carbide-coated fuels and the design approach selected for the cold pilot plant crusher, and shows how the design addresses the equipment goals and operational objectives. Design calculations and considerations are included to support the selection of crusher drive and gearing, the materials chosen for crushing rolls and housing, and the bearing selection. The results of the initial testing for compliance with design objectives and operational capabilities are also presented. 8 figures, 4 tables

A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis.

Science.gov (United States)

Colbert, James F; Ford, Joshay A; Haeger, Sarah M; Yang, Yimu; Dailey, Kyrie L; Allison, Kristen C; Neudecker, Viola; Evans, Christopher M; Richardson, Vanessa L; Brodsky, Kelley S; Faubel, Sarah; Eltzschig, Holger K; Schmidt, Eric P; Ginde, Adit A

2017-08-01

Sepsis outcomes are heavily dependent on the development of septic organ injury, but no interventions exist to interrupt or reverse this process. microRNA-223 (miR-223) is known to be involved in both inflammatory gene regulation and host-pathogen interactions key to the pathogenesis of sepsis. The goal of this study was to determine the role of miR-223 as a mediator of septic kidney injury. Using miR-223 knockout mice and multiple models of experimental sepsis, we found that miR-223 differentially influences acute kidney injury (AKI) based on the model used. In the absence of miR-223, mice demonstrated exaggerated AKI in sterile models of sepsis (LPS injection) and attenuated AKI in a live-infection model of sepsis (cecal ligation and puncture). We demonstrated that miR-223 expression is induced in kidney homogenate after cecal ligation and puncture, but not after LPS or fecal slurry injection. We investigated additional potential mechanistic explanations including differences in peritoneal bacterial clearance and host stool virulence. Our findings highlight the complex role of miR-223 in the pathogenesis of septic kidney injury, as well as the importance of differences in experimental sepsis models and their consequent translational applicability. Copyright © 2017 the American Physiological Society.

Experimental study of inhalation injury

International Nuclear Information System (INIS)

Hamamoto, Junji; Ohura, Takehiko; Yoshida, Tetsunori; Ono, Ichiro; Iida, Kazunori; Ooiwa, Akira

1984-01-01

We conducted the following inhalation injury experiment on dogs. A hose was connected to the chimney of a stove so that wood smoke could be led to the dog by means of damper adjustment. Under intravenous anesthesia, the dog was intubated and made to inhale the wood smoke for from 5 to 10 minutes at a smoke temperature of between 55 and 60 C. After this inhalation, observation of trachea by a fiberoptic bronchoscopy was done and blood gas change, blood analysis, serum electrolytes and cardiac output were observed with a passage of time. Furthermore, we did lung scan using 133xe and performed autopsies. We injected 0.3 microcurie of 133Xe per 1 kg body weight in its vein of the dog's foreleg. The concentration in the lung reached maximum 20 seconds after the injection and then washed out with expiration. In the control experiment with a normal dog, it was almost all washed out 70 seconds after the 133Xe injection. But the delay of wash out time was observed in smoke inhaled dogs. In other words it can be said that the wash out time was dependent on the degree of injury. When these data were processed by a computer, and exponential approximation decay curve was obtained. Then these data were replotted into semi-logarithmic chart and a linear line was obtained. One may interprete the clearance rate recorded on the graph as the ability of the lung to wash out 133Xe, that is, the degree of injury of the lung. The clearance rate had a tendancy to concentrate between 3.5 to 5.0 when observed 2 to 7 hours after the injury. However when observed 20 to 27 hours, concentration was between 2.4 to 3.2. Furthermore, the clearance rate for each lung regions were obtained and compared with one another by means of proper computer program. The clearance rate had lower values at lower region of lung, that is, deterioration of lung function was greater. (J.P.N.)

Fingertip injuries in paediatric patients ---- experiences at an emergency centre in Saudi Arabia

International Nuclear Information System (INIS)

Anazi, A.F.A.

2013-01-01

Objectives: To investigate the etiological factors, intensity of injuries and the possible preventive measures of fingertip injuries and to avert such calamities. Methods: A study was undertaken retrospectively on 200 children who had presented with fingertip injuries to the Paediatric Emergency Department of the King Saud bin Abdulaziz University for Health Sciences, during the years 2010-2011. The markers analyzed included age and sex of the patients, period when the injury occurred (vacation and/or non-vacation), accommodation, where the children dwelled, source of injury, localization of the injury, fracture or tendon damage, and modality of treatment. Results: The frequency of injuries was highest among younger children (< 5 years). Majority of injuries were found to occur during vacation period among patients who dwell in apartments and villas at residential compounds. House doors were the most common mode of crush injuries. The frequency of fractures was found to be more frequent in boys vs. girls. Suturing and conservative treatment were common mode of treatments. Of the total, 188 patients who attended the emergency had proper movement and alignment by the end of their treatment, while 12 patients demonstrated complications. Conclusion: Children below 5 years age were involved in fingertip injuries in a large number. Injuries were more common in vacations and in children living in appartments. Preventive measures are necessary to avoid these accidents. (author)

Use of waste crushed glass for the production of hot-mix asphalt

CSIR Research Space (South Africa)

Anochie-Boateng, Joseph

2016-08-01

Full Text Available presents the development and evaluation of a new asphalt concrete mix that utilizes a sustainable crushed glass as a replacement material of a natural aggregate. The ultimate goal is to produce a cost-effective asphalt wearing course with comparative...

Degeneration and regeneration of motor and sensory nerves: a stereological study of crush lesions in rat facial and mental nerves

DEFF Research Database (Denmark)

Barghash, Ziad; Larsen, Jytte Overgaard; Al-Bishri, Awad

2013-01-01

The aim of this study was to evaluate the degeneration and regeneration of a sensory nerve and a motor nerve at the histological level after a crush injury. Twenty-five female Wistar rats had their mental nerve and the buccal branch of their facial nerve compressed unilaterally against a glass rod...... for 30 s. Specimens of the compressed nerves and the corresponding control nerves were dissected at 3, 7, and 19 days after surgery. Nerve cross-sections were stained with osmium tetroxide and toluidine blue and analysed using two-dimensional stereology. We found differences between the two nerves both...... in the normal anatomy and in the regenerative pattern. The mental nerve had a larger cross-sectional area including all tissue components. The mental nerve had a larger volume fraction of myelinated axons and a correspondingly smaller volume fraction of endoneurium. No differences were observed...

Influence of technical parameters of disk-shaped reactor on productivity of heat treatment of crushed wood

Science.gov (United States)

Safin, R. R.; Khasanshin, R. R.; Mukhametzyanov, S. R.

2018-03-01

The existing installations for heat treatment of the crushed wood are analyzed. The technology of heat treatment of the crushed wood in the devices of disk-shaped type is offered. The results of modeling for the purpose of determination of interrelation of the key design and technological parameters of the disk-shaped device are presented. It is established that the major factors, affecting duration of stay of the material in a device, are the speed of rotation of the mixer, the number of mixers and the number of rakes on the mixer.

Wastes disposal on board a ship. Crushing and volume reducing apparatus for combustible and non-combustible refuses; Senjo no haikibutsu shori. Kanen funen gomi no hasai gen`yo shori sochi

Energy Technology Data Exchange (ETDEWEB)

Kishida, Y. [Hitachi Zosen Corp., Osaka (Japan)

1996-07-25

This paper introduces a refuse crushing apparatus to reduce for storage the volume of refuses produced on board a ship by crushing. Refuses to be crushed are solid wastes including solid combustible refuses such as paper, wood pieces, and cloths, non-combustible refuses such as empty cans, metals and glass, and refuses unsuitable for combustion, such as plastics and stylofoam. Crushing methods include impact system, compression system and shearing system. The shearing system shears and crushes refuses by using blades rotating at a low speed. The system has a wide range of crush ability and excellent versatility, generates low levels of dust, noise and vibration, and is suitable as a marine use refuse disposing apparatus. However, empty cans and PET bottles are more difficult of getting into cutting blades requiring a large amount of time for crushing. Therefore, it is more suitable to reduce volume of refuses by using a compressor or the like apparatuses, and then crush them by using a double-axial shearing crusher. Stylofoam causes its crushed pieces to be electrically charged and deposited onto the apparatus, hence it is more suitable to reduce the volume of refuses and make them brittle by heating, and then crush them by using the double-axial crusher. 2 figs.

Crushing damage estimation for pavement with lightly cementitious bases

CSIR Research Space (South Africa)

De Beer, Morris

2014-07-01

Full Text Available . Department of Transport. Pretoria, South Africa. Litwinowicz and De Beer., 2013. Long term crushing performance of lightly cementitious pavement materials – update to the South African procedures. Road Materials and Pavement Design. Maina, J.W., De... Beer, M. and van Rensburg, Y., 2013. Modelling Tyre-Road Contact Stresses in Pavement Design and Analysis. Proceedings of 32nd Southern Africa transport conference, Pretoria, July 2013. pp 336-345: SAPDM, (2014). http://www.sapdm.co.za/, last...

Robust human body model injury prediction in simulated side impact crashes.

Science.gov (United States)

Golman, Adam J; Danelson, Kerry A; Stitzel, Joel D

2016-01-01

This study developed a parametric methodology to robustly predict occupant injuries sustained in real-world crashes using a finite element (FE) human body model (HBM). One hundred and twenty near-side impact motor vehicle crashes were simulated over a range of parameters using a Toyota RAV4 (bullet vehicle), Ford Taurus (struck vehicle) FE models and a validated human body model (HBM) Total HUman Model for Safety (THUMS). Three bullet vehicle crash parameters (speed, location and angle) and two occupant parameters (seat position and age) were varied using a Latin hypercube design of Experiments. Four injury metrics (head injury criterion, half deflection, thoracic trauma index and pelvic force) were used to calculate injury risk. Rib fracture prediction and lung strain metrics were also analysed. As hypothesized, bullet speed had the greatest effect on each injury measure. Injury risk was reduced when bullet location was further from the B-pillar or when the bullet angle was more oblique. Age had strong correlation to rib fractures frequency and lung strain severity. The injuries from a real-world crash were predicted using two different methods by (1) subsampling the injury predictors from the 12 best crush profile matching simulations and (2) using regression models. Both injury prediction methods successfully predicted the case occupant's low risk for pelvic injury, high risk for thoracic injury, rib fractures and high lung strains with tight confidence intervals. This parametric methodology was successfully used to explore crash parameter interactions and to robustly predict real-world injuries.

Injuries, envenomations and stings from exotic pets.

Science.gov (United States)

Warwick, Clifford; Steedman, Catrina

2012-07-01

A variety of exotic vertebrate and invertebrate species are kept as 'pets' including fishes, amphibians (for example, frogs and toads), reptiles (turtles, crocodiles, lizards and snakes), birds, mammals (for example, primates, civets, and lions), and invertebrates (for example spiders, scorpions, and centipedes), and ownership of some of these animals is rising. Data for 2009-2011 suggest that the number of homes with reptiles rose by approximately 12.5%. Recent surveys, including only some of these animals, indicated that they might be present in around 18.6% of homes (equal to approximately 42 million animals of which around 40 million are indoor or outdoor fish). Many exotic 'pets' are capable of causing injury or poisoning to their keepers and some contacts prove fatal. We examined NHS Health Episode Statistics for England using selected formal categories for hospital admissions and bed days for 2004-2010 using the following categories of injury, envenomation or sting; bitten or struck by crocodile or alligator; bitten or crushed by other reptiles: contact with venomous snakes and lizards; contact with scorpions. Between 2004 and 2010 these data conservatively show a total of 760 full consultation episodes, 709 admissions and 2,121 hospital bed days were associated with injuries probably from exotic pets. Injuries, envenomations and stings from exotic pets constitute a small but important component of emerging medical problems. Greater awareness of relevant injuries and medical sequelae from exotic pet keeping may help medics formulate their clinical assessment and advice to patients.

Experimental Models of Status Epilepticus and Neuronal Injury for Evaluation of Therapeutic Interventions

Directory of Open Access Journals (Sweden)

Ramkumar Kuruba

2013-09-01

Full Text Available This article describes current experimental models of status epilepticus (SE and neuronal injury for use in the screening of new therapeutic agents. Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. SE is an emergency condition associated with continuous seizures lasting more than 30 min. It causes significant mortality and morbidity. SE can cause devastating damage to the brain leading to cognitive impairment and increased risk of epilepsy. Benzodiazepines are the first-line drugs for the treatment of SE, however, many people exhibit partial or complete resistance due to a breakdown of GABA inhibition. Therefore, new drugs with neuroprotective effects against the SE-induced neuronal injury and degeneration are desirable. Animal models are used to study the pathophysiology of SE and for the discovery of newer anticonvulsants. In SE paradigms, seizures are induced in rodents by chemical agents or by electrical stimulation of brain structures. Electrical stimulation includes perforant path and self-sustaining stimulation models. Pharmacological models include kainic acid, pilocarpine, flurothyl, organophosphates and other convulsants that induce SE in rodents. Neuronal injury occurs within the initial SE episode, and animals exhibit cognitive dysfunction and spontaneous seizures several weeks after this precipitating event. Current SE models have potential applications but have some limitations. In general, the experimental SE model should be analogous to the human seizure state and it should share very similar neuropathological mechanisms. The pilocarpine and diisopropylfluorophosphate models are associated with prolonged, diazepam-insensitive seizures and neurodegeneration and therefore represent paradigms of refractory SE. Novel mechanism-based or clinically relevant models are essential to identify new therapies for SE and neuroprotective interventions.

Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis

International Nuclear Information System (INIS)

Joshi, Nikita; Kopec, Anna K.; Cline-Fedewa, Holly; Luyendyk, James P.

2017-01-01

The etiology of chronic bile duct injury and fibrosis in patients with autoimmune cholestatic liver diseases is complex, and likely involves immune cells such as lymphocytes. However, most models of biliary fibrosis are not autoimmune in nature. Biliary fibrosis can be induced experimentally by prolonged exposure of mice to the bile duct toxicant alpha-naphthylisothiocyanate (ANIT). We determined whether lymphocytes contributed to ANIT-mediated biliary hyperplasia and fibrosis in mice. Hepatic accumulation of T-lymphocytes and increased serum levels of anti-nuclear-autoantibodies were evident in wild-type mice exposed to ANIT (0.05% ANIT in chow). This occurred alongside bile duct hyperplasia and biliary fibrosis. To assess the role of lymphocytes in ANIT-induced biliary fibrosis, we utilized RAG1 −/− mice, which lack T- and B-lymphocytes. ANIT-induced bile duct injury, indicated by increased serum alkaline phosphatase activity, was reduced in ANIT-exposed RAG1 −/− mice compared to ANIT-exposed wild-type mice. Despite this reduction in biliary injury, ANIT-induced bile duct hyperplasia was similar in wild-type and RAG1 −/− mice. However, hepatic induction of profibrogenic genes including COL1A1, ITGβ6 and TGFβ2 was markedly attenuated in ANIT-exposed RAG1 −/− mice compared to ANIT-exposed wild-type mice. Peribiliary collagen deposition was also reduced in ANIT-exposed RAG1 −/− mice. The results indicate that lymphocytes exacerbate bile duct injury and fibrosis in ANIT-exposed mice without impacting bile duct hyperplasia.

Comparison of the effects of intravitreal bevacizumab and dexamethasone in experimental posterior penetrating eye injury

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Ayse Oner

2018-04-01

Full Text Available AIM: To compare the effects of intravitreal anti-vascular endothelial growth factor (VEGF and dexamethasone in an experimental rabbit model of posterior penetrating ocular injury. METHODS: Thirty white New Zealand rabbits were included in the study. A posterior penetrating ocular injury was performed at the superotemporal quadrant. They were randomly divided into three groups. The rabbits in group 1 received intravitreal dexamethasone, in group 2 they received intravitreal bevacizumab and those in group 3 received intravitreal physiological saline solution in both eyes. All eyes were examined ophthalmologically on the 1st, 3rd, 7th, 14th and 28th days following the injury and the clinical findings were scored. On the day 28, the eyes were enucleated, evaluated and scored macroscopically, histopathologically and scanning electron microscopically. RESULTS: The median clinical score on the 14th and 28th days and the median macroscopic score of the dexamethasone group was significantly better than that of control (P=0.004, 0.018. Dexamethasone group was also better than that of bevacizumab group but the differences did not reach statistical significance. Retinal detachment rate was 8.3%, 16.6% and 12.5% in the dexamethasone group, bevacizumab group and control group, respectively (P=0.476. More extensive fibrocelluler proliferations were observed in controls compared with dexamethasone and bevacizumab groups. But these differences did not reach the statistical significance (P=0.538. In scanning electron microscopy all groups showed fibreous stalk and dense collagen fibrils in vitreous. CONCLUSION: This study shows that intravitreal injection of both dexamethasone and bevacizumab may reduce the intraocular fibrous proliferation after an experimental posterior penetrating ocular injury in rabbits.

Serotonin induces memory-like, rapamycin-sensitive hyperexcitability in sensory axons of aplysia that contributes to injury responses.

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Weragoda, Ramal M S; Walters, Edgar T

2007-09-01

The induction of long-term facilitation (LTF) of synapses of Aplysia sensory neurons (SNs) by serotonin (5-HT) has provided an important mechanistic model of memory, but little is known about other long-term effects of 5-HT on sensory properties. Here we show that crushing peripheral nerves results in long-term hyperexcitability (LTH) of the axons of these nociceptive SNs that requires 5-HT activity in the injured nerve. Serotonin application to a nerve segment induces local axonal (but not somal) LTH that is inhibited by 5-HT-receptor antagonists. Blockade of crush-induced axonal LTH by an antagonist, methiothepin, provides evidence for mediation of this injury response by 5-HT. This is the first demonstration in any axon of neuromodulator-induced LTH, a phenomenon potentially important for long-lasting pain. Methiothepin does not reduce axonal LTH induced by local depolarization, so 5-HT is not required for all forms of axonal LTH. Serotonin-induced axonal LTH is expressed as reduced spike threshold and increased repetitive firing, whereas depolarization-induced LTH involves only reduced threshold. Like crush- and depolarization-induced LTH, 5-HT-induced LTH is blocked by inhibiting protein synthesis. Blockade by rapamycin, which also blocks synaptic LTF, is interesting because the eukaryotic protein kinase that is the target of rapamycin (TOR) has a conserved role in promoting growth by stimulating translation of proteins required for translation. Rapamycin sensitivity suggests that localized increases in translation of proteins that promote axonal conduction and excitability at sites of nerve injury may be regulated by the same signals that increase translation of proteins that promote neuronal growth.

Apneic oxygenation combined with extracorporeal arteriovenous carbon dioxide removal provides sufficient gas exchange in experimental lung injury

DEFF Research Database (Denmark)

Nielsen, Niels Dalsgaard; Kjærgaard, Benedict; Koefoed-Nielsen, Jacob

2008-01-01

We hypothesized that apneic oxygenation, using an open lung approach, combined with extracorporeal CO2 removal, would provide adequate gas exchange in acute lung injury. We tested this hypothesis in nine anesthetized and mechanically ventilated pigs (85-95 kg), in which surfactant was depleted fr....../min. Thus, the method provided adequate gas exchange in this experimental model, suggesting that it might have potential as an alternative treatment modality in acute lung injury.......We hypothesized that apneic oxygenation, using an open lung approach, combined with extracorporeal CO2 removal, would provide adequate gas exchange in acute lung injury. We tested this hypothesis in nine anesthetized and mechanically ventilated pigs (85-95 kg), in which surfactant was depleted from...

Modeling the fate transport of cesium in crushed granite

International Nuclear Information System (INIS)

Lee, C.B.; Kuo, Y.M.; Hsu, C.N.; Li, M.H.; Cheng, H.P.; Teng, S.P.

2005-01-01

Full text of publication follows: In order to assess the safety of a underground radwaste repository, reactive transport models suitable for evaluating the fate and transport of radionuclides need to be established based on experimental observation and analysis. The goal of this study is to construct adequate models simulating the reactive transport of cesium (Cs) in crushed granite through a systematic analysis, where synthetic groundwater (SGW) and synthetic seawater (SSW) were employed as the liquid phase. To build such models, this study applied N 2 -BET, x-ray diffraction (XRD), polar-microscopy/ auto-radiography, and solid-phase digestion for the analysis of granite, kinetic batch tests for the characterization of sorption/desorption of Cs, and multi-stage advection-dispersion column tests for the determination of major transport processes and the calibration/validation of hypothesized reactive transport models. Based on the results of solid phase analysis and batch tests, a two-site Langmuir kinetic model has been determined capable of appropriately describing Cs sorption/desorption under test conditions. From the results of non-reactive HTO column tests, a mobile/immobile transport model was proposed to capture the major transport processes in our column system. However, the combination of the two-site Langmuir model and the mobile/immobile transport model failed to provide numerical breakthrough curves matching the Cs experimental breakthroughs. It implied that our model needs to be further refined. To achieve this, the setup of our column test needs to be modified first to reduce the volume of column connecting space, so that the effect of extra diffusion/dispersion on breakthroughs would be minimized and major transport characteristics can be clearly revealed. Moreover, more investigations on the reaction mechanisms and transport processes of the reactive transport system must be conducted. (authors)

Cement Type Influence on Alkali-Silica Reaction in Concrete with Crushed Gravel Aggregate

Science.gov (United States)

Rutkauskas, A.; Nagrockienė, D.; Skripkiūnas, G.

2017-10-01

Alkali-silica reaction is one of the chemical reactions which have a significant influence for durability of concrete. During alkali and silica reaction, silicon located in aggregates of the concrete, reacts with high alkali content. This way in the micropores of concrete is forming hygroscopic gel, which at wet environment, expanding and slowly but strongly destroying concrete structures. The goal of this paper- to determine the influence of cement type on alkali-silica reaction of mortars with crushed gravel. In the study crushed gravel with fraction 4/16 mm was used and four types of cements tested: CEM I 42.5 R; CEM I 42.5 SR; CEM II/A-S 42.5; CEM II/A-V 52.5. This study showed that crushed gravel is low contaminated on reactive particles containing of amorphous silica dioxide. The expansion after 14 days exceed 0.054 %, by RILEM AAR-2 research methodology (testing specimen dimension 40×40×160 mm). Continuing the investigation to 56 days for all specimens occurred alkaline corrosion features: microcracking and the surface plaque of gel. The results showed that the best resistance to alkaline corrosion after 14 days was obtained with cement CEM I 42.5 SR containing ash additive, and after 56 days with cement CEM II/A-V 52.5 containing low alkali content. The highest expansion after 14 and 56 days was obtained with cement CEM I 42.5 R without active mineral additives.

Low-Intensity Pulsed Ultrasound Protects Retinal Ganglion Cell From Optic Nerve Injury Induced Apoptosis via Yes Associated Protein

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Jia-Xing Zhou

2018-06-01

Full Text Available Background: Low-intensity pulsed ultrasound (LIPUS has been used in clinical studies. But little is known about its effects on the central nervous system (CNS, or its mechanism of action. Retinal ganglion cells (RGCs are CNS neuronal cells that can be utilized as a classic model system to evaluate outcomes of LIPUS protection from external trauma-induced retinal injury. In this study, we aim to: (1 determine the pulse energy and the capability of LIPUS in RGC viability, (2 ascertain the protective role of LIPUS in optic nerve (ON crush-induced retinal injury, and 3 explore the cellular mechanisms of RGC apoptosis prevention by LIPUS.Methods: An ON crush model was set up to induce RGC death. LIPUS was used to treat mice eyes daily, and the retina samples were dissected for immunostaining and Western blot. The expression of yes-associated protein (YAP and apoptosis-related proteins was detected by immunostaining and Western blot in vitro and in vivo. Apoptosis of RGCs was evaluated by TUNEL staining, the survival of RGCs and retained axons were labeled by Fluoro-gold and Tuj1 antibody, respectively. Rotenone was used to set up an in vitro cellular degenerative model and siYAP was used to interfering the expression of YAP to detect the LIPUS protective function.Results: LIPUS protected RGC from loss and apoptosis in vivo and in vitro. The ratio of cleaved/pro-caspase3 also decreased significantly under LIPUS treatment. As a cellular mechanical sensor, YAP expression increased and YAP translocated to nucleus in LIPUS stimulation group, however, phospho-YAP was found to be decreased. When YAP was inhibited, the LIPUS could not protect RGC from caspase3-dependent apoptosis.Conclusion: LIPUS prevented RGCs from apoptosis in an ON crush model and in vitro cellular degenerative model, which indicates a potential treatment for further traumatic ON injury. The mechanism of protection is dependent on YAP activation and correlated with caspase-3 signaling.

Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies.

Science.gov (United States)

Vonder Haar, Cole; Peterson, Todd C; Martens, Kris M; Hoane, Michael R

2016-06-01

With the numerous failures of pharmaceuticals to treat traumatic brain injury in humans, more researchers have become interested in combination therapies. This is largely due to the multimodal nature of damage from injury, which causes excitotoxicity, oxidative stress, edema, neuroinflammation and cell death. Polydrug treatments have the potential to target multiple aspects of the secondary injury cascade, while many previous therapies focused on one particular aspect. Of specific note are vitamins, minerals and nutrients that can be utilized to supplement other therapies. Many of these have low toxicity, are already FDA approved and have minimal interactions with other drugs, making them attractive targets for therapeutics. Over the past 20 years, interest in supplementation and supraphysiologic dosing of nutrients for brain injury has increased and indeed many vitamins and nutrients now have a considerable body of the literature backing their use. Here, we review several of the prominent therapies in the category of nutraceutical treatment for brain injury in experimental models, including vitamins (B2, B3, B6, B9, C, D, E), herbs and traditional medicines (ginseng, Gingko biloba), flavonoids, and other nutrients (magnesium, zinc, carnitine, omega-3 fatty acids). While there is still much work to be done, several of these have strong potential for clinical therapies, particularly with regard to polydrug regimens. This article is part of a Special Issue entitled SI:Brain injury and recovery. Copyright © 2016 Elsevier B.V. All rights reserved.

Management of high-energy foot and ankle injuries in the geriatric population.

Science.gov (United States)

Herscovici, Dolfi; Scaduto, Julia M

2012-03-01

By the year 2035 almost 20% of the US population of 389 million people will be 65 years and older. What this group has, compared with aged populations in the past, is better health, more mobility, and more active lifestyles. From January 1989 through December 2010, a total of 494 elderly patients with 536 foot and ankle injuries were identified. Within this group, 237 (48%) patients with 294 injuries were sustained as a result of a high-energy mechanism. These mechanisms consisted of 170 motor vehicle accidents, 30 as a result of high (not ground level) energy falls, 2 from industrial accidents, and 35 classified as other, which included sports, blunt trauma, bicycle, airplane or boating accidents, crush injuries, and injuries resulting from a lawn mower. The injuries produced were 17 metatarsal fractures, 9 Lisfranc injuries, 10 midfoot (navicular, cuneiform, or cuboid) fractures, 23 talus fractures, 63 calcaneal fractures, 73 unimalleolar, bimalleolar, or trimalleolar ankle fractures, 45 pilon fractures, and 3 pure dislocations of the foot or ankle. Overall, 243 (83%) of these injuries underwent surgical fixation and data have shown that when surgery is used to manage high-energy injuries of the foot and ankle in the elderly individuals, the complications and outcomes are similar to those seen in younger patients. Therefore, the decision for surgical intervention for high-energy injuries of the foot and ankle should be based primarily on the injury pattern and not solely on the age of the patient.

Mediators' Emotional Responses to Self-Injurious Behavior: An Experimental Study.

Science.gov (United States)

Mossman, Dominique A.; Hastings, Richard P.; Brown, Tony

2002-01-01

Sixty mediators from British schools for children with mental retardation watched one of five matched videos depicting no self-injury, self-injury maintained by positive reinforcement, self-injury maintained by negative reinforcement, and self-injury unrelated to social events. Self-injury maintained by negative reinforcement was associated with…

Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy—These Matters Matter

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Mark W. Wojnarowicz

2017-06-01

Full Text Available Animal models of concussion, traumatic brain injury (TBI, and chronic traumatic encephalopathy (CTE are widely available and routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration of four basic principles. First, animal model use must be guided by clarity of definitions regarding the human disease or condition being modeled. Concussion, TBI, and CTE represent distinct clinical entities that require clear differentiation: concussion is a neurological syndrome, TBI is a neurological event, and CTE is a neurological disease. While these conditions are all associated with head injury, the pathophysiology, clinical course, and medical management of each are distinct. Investigators who use animal models of these conditions must take into account these clinical distinctions to avoid misinterpretation of results and category mistakes. Second, model selection must be grounded by clarity of purpose with respect to experimental questions and frame of reference of the investigation. Distinguishing injury context (“inputs” from injury consequences (“outputs” may be helpful during animal model selection, experimental design and execution, and interpretation of results. Vigilance is required to rout out, or rigorously control for, model artifacts with potential to interfere with primary endpoints. The widespread use of anesthetics in many animal models illustrates the many ways that model artifacts can confound preclinical results. Third, concordance between key features of the animal model and the human disease or condition being modeled is required to confirm model biofidelity. Fourth, experimental results observed in animals must be confirmed in human subjects for model validation. Adherence to these principles serves as a bulwark against flawed interpretation of results, study replication failure, and confusion in the field. Implementing these principles will advance basic science discovery and

It is time for a better clip applier - 3 mm, percutaneous, non-crushing and locking.

Science.gov (United States)

Yuval, Jonathan B; Weiss, Daniel J; Paz, Adrian; Bachar, Yehuda; Brodie, Ronit; Shapira, Yinon; Mintz, Yoav

2017-10-06

Since the advent of laparoscopy there have been attempts to minimize abdominal wall incisions. For this purpose smaller instruments have been produced. Our aim was to develop the first 3 mm percutaneous clip applier and to make it better than the standard clips of today. The ClipTip clip is made of Nitinol and has a crocodile shaped jaws, which when apposed effectively seal vessels. The shaft operates as a retractable needle permitting percutaneous insertion. Closing, reopening and reclosing is possible. The physical properties of the device were compared to three commercially available clip appliers. Surgeries were performed on porcine animals by experienced surgeons. In comparison to available clips, the superiority of the ClipTip is a combination of wide effective length alongside the ability to withstand strong forces. In live animal studies the Cliptip was inserted into the peritoneal cavity without any injuries. Vessels were ligated successfully and no clip dislodgement or leakage occurred. We developed the next generation clip applier with better properties. Advantages include its length, the needleoscopic caliber, non-crushing effect, locking mechanism and wide aperture. The device has performed safely and effectively in pre-clinical tests. Further studies are planned in humans.

Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury.

Science.gov (United States)

Succar, Lena; Pianta, Timothy J; Davidson, Trent; Pickering, John W; Endre, Zoltán H

2017-09-01

Extensive structural damage within the kidney must be present before serum creatinine increases. However, a subclinical phase of chronic kidney disease (CKD) usually goes undetected. Here we tested whether experimental subclinical CKD would modify functional and damage biomarker profiles of acute kidney injury (AKI). Subclinical CKD was induced in rats by adenine or aristolochic acid models but without increasing serum creatinine. After prolonged recovery (three to six weeks), AKI was induced with a subnephrotoxic dose of cisplatin. Urinary levels of kidney injury molecule-1 (KIM-1), cytochrome C, monocyte chemotactic protein-1 (MCP-1), clusterin, and interleukin-18 increased during CKD induction, without an increase in serum creatinine. After AKI in adenine-induced CKD, serum creatinine increased more rapidly, while increased urinary KIM-1, clusterin, and MCP-1 were delayed and reduced. Increased serum creatinine and biomarker excretion were associated with diffuse tubulointerstitial injury in the outer stripe of outer medulla coupled with over 50% cortical damage. Following AKI in aristolochic acid-induced CKD, increased serum creatinine, urinary KIM-1, clusterin, MCP-1, cytochrome C, and interleukin-18 concentrations and excretion were greater at day 21 than day 42 and inversely correlated with cortical injury. Subclinical CKD modified functional and damage biomarker profiles in diametrically opposite ways. Functional biomarker profiles were more sensitive, while damage biomarker diagnostic thresholds and increases were diminished and delayed. Damage biomarker concentrations and excretion were inversely linked to the extent of prior cortical damage. Thus, thresholds for AKI biomarkers may need to be lower or sampling delayed in the known presence of CKD. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

The influence of crushed rock salt particle gradation on compaction

International Nuclear Information System (INIS)

Ran, C.; Daemen, J.J.K.

1994-01-01

This paper presents results of laboratory compaction testing to determine the influence of particle size, size gradation and moisture-content on compaction of crushed rock salt. Included is a theoretical analysis of the optimum size gradation. The objective is to evaluate the relative densities that can be achieved with tamping techniques. Initial results indicate that compaction increases with maximum particle size and compaction energy, and varies significantly with article size gradation and water content

Effect of moisture content on the flowability of crushed ores

OpenAIRE

Cabrejos Francisco

2017-01-01

In many mining and industrial processes where large quantities of non-degrading bulk materials such as crushed ores are handled, silos, hoppers, stockpiles and chutes are widely used because they are economical and reliable (if properly designed and operated). However, they are not free of trouble and may experience flow problems such as arching, ratholing, erratic flow, limited storage capacity, limited discharge flow rate, caking, segregation and/or flooding. Moisture content and fine parti...

Representative-Sandwich Model for Mechanical-Crush and Short-Circuit Simulation of Lithium-ion Batteries

Energy Technology Data Exchange (ETDEWEB)

Zhang, Chao; Santhanagopalan, Shriram; Sprague, Michael A.; Pesaran, Ahmad A.

2015-07-28

Lithium-ion batteries are currently the state-of-the-art power sources for a variety of applications, from consumer electronic devices to electric-drive vehicles (EDVs). Being an energized component, failure of the battery is an essential concern, which can result in rupture, smoke, fire, or venting. The failure of Lithium-ion batteries can be due to a number of external abusive conditions (impact/crush, overcharge, thermal ramp, etc.) or internal conditions (internal short circuits, excessive heating due to resistance build-up, etc.), of which the mechanical-abuse-induced short circuit is a very practical problem. In order to better understand the behavior of Lithium-ion batteries under mechanical abuse, a coupled modeling methodology encompassing the mechanical, thermal and electrical response has been developed for predicting short circuit under external crush.

Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats

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Henrique Budib Dorsa Pontes

Full Text Available Abstract Introduction: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning. Methods: 41 Wistar rats (Rattus norvegicus albinus were distributed in 5 groups: Ischemia and Reperfusion (A, Ischemic Postconditioning (B, Statin (C, Ischemic Postconditioning + Statins (D and SHAM (E. After euthanasia, lungs, liver, kidneys and ileum were resected and submitted to histopathological analysis. Results: The average of lung parenchymal injury was A=3.6, B=1.6, C=1.2, D=1.2, E=1 (P=0.0029. The average of liver parenchymal injury was A=3, B=1.5, C=1.2, D=1.2, E = 0 (P<0.0001. The average of renal parenchymal injury was A=4, B=2.44, C=1.22, D=1.11, E=1 (P<0.0001. The average of intestinal parenchymal injury was A=2, B=0.66, C=0, D=0, E=0 (P=0.0006. The results were submitted to statistics applying Kruskal-Wallis test, estabilishing level of significance P<0.05. Conclusion: Groups submitted to ischemic postconditioning, to pre-treatment with statins and both methods associated demonstrated less remote reperfusion injuries, compared to the group submitted to ischemia and reperfusion without protection.

Crush performance of redwood for developing design procedures for impact limiters

International Nuclear Information System (INIS)

Cramer, S.M.; Hermanson, J.C.; McMurtry, W.M.

1995-01-01

Containers for the transportation of hazardous and radioactive materials incorporate redwood in impact limiters. Redwood is an excellent energy absorber, but only the most simplistic information exists on its crush properties. Tbe stress-strain interrelationship for any wood species subject to three-dimensional stresses is largely unknown for any all stress condition and wood behavior at both high strains and high strain-rates is known only in general terms. Both stress-strain and crush failure theories have been developed based only on uniaxial load tests. The anisotropy of wood adds an additional complexity to measuring wood response and developing suitable theories to describe it. A long history of wood utilization in the building industry has led to design procedures and property information related to simple uniaxial loadings that do not inflict damage to the wood. This lack of knowledge may be surprising for a material that has a long history of engineered use, but the result is difficulty in utilizing wood in more sophisticated designs such as impact limiters. This study provides a step toward filling the information gap on wood material response for high performance applications such as impact limiters

Genetic parameters of the piglet mortality traits stillborn, weak at birth, starvation, crushing, and miscellaneous in crossbred pigs

DEFF Research Database (Denmark)

Strange, T.; Ask, B.; Nielsen, B.

2013-01-01

This study aimed to estimate genetic parameters for the mortality causes stillborn, weak at birth, starvation, crushing, and miscellaneous in crossbred piglets produced by crossbred dams. Data were collected in a single Danish commercial herd from October 2006 to July 2008 and consisted of 34......,194 piglets (2,152 litters), which originated from 195 Danish Duroc sires and 955 crossbreds between Danish Landrace and Danish Yorkshire dams. Of the 34,194 piglets born, 11.5% were stillborn, 4.2% were crushed by the sow, 2.7% died due to starvation, 2.3% were weak at birth, and 2.2% died of miscellaneous...... traits based on the sire component ranged from -0.05 between stillborn and starvation to 0.35 between stillborn and weak at birth whereas genetic correlations based on the dam component ranged from -0.11 between weak at birth and starvation to 0.76 between crushing and starvation. There seemed...

Performance of PWR buidings in case of airplane crush

International Nuclear Information System (INIS)

L'Huby, Y.; Barbe, B.

1992-02-01

Safety standards for the French nuclear power plants are defined in RCC-G. For the risk estimation of airplan crush two type of planes are considered: Lear-Jet 23, and Cesna 210. For estimating the resistance to impact shock of the reactor building deformation criteria were established for concrete and steel reinforcement. A practical calculation method is recommended in RCC-G. Results contain data resulting from impact shock dependent on the military plane type and speed. Finite element method was applied as well as simplified method proposed by Comite Europeen du Breton

The axial crushes behaviour on foam-filled round Jute/Polyester composite tubes

Science.gov (United States)

Othman, A.; Ismail, A. E.

2018-04-01

The present paper investigates the effect of axial loading compression on jute fibre reinforced polyester composite round tubes. The specimen of composite tube was fabricated by hand lay-up method of 120 mm length with fix 50.8 mm inner diameter to determine the behaviour of energy absorption on number of layers of 450 angle fibre and internally reinforced with and without foam filler material. The foam filler material used in this studies were polyurethane (PU) and polystyrene (PE) with average of 40 and 45 kg/m3 densities on the axial crushing load against displacement relations and on the failure modes. The number of layers of on this study were two; three and four were selected to calculate the crush force efficiency (CFE) and the specific energy absorption (SEA) of the composite tubes. Result indicated that the four layers’ jute/polyester show significant value in term of crushing load compared to 2 and 3 layers higher 60% for 2 layer and 3% compared to 3 layers. It has been found that the specific energy absorption of the jute/polyester tubes with polystyrene foam-filled is found higher respectively 10% to 12% than empty and polyurethane (PU) foam tubes. The increase in the number of layers from two to four increases the mean axial load from 1.01 KN to 3.60 KN for empty jute/polyester and from 2.11 KN to 4.26 KN for the polyurethane (PU) foam-filled jute/polyester tubes as well as for 3.60 KN to 5.58 KN for the polystyrene (PE) foam-filled jute/polyester. The author’s found that the failure of mechanism influence the characteristic of curve load against displacement obtained and conclude that an increasing number of layers and introduce filler material enhance the capability of specific absorbed energy.

Indirect MR-arthrography in osteochondral autograft and crushed bone graft with a collagen membrane-Correlation with histology

Energy Technology Data Exchange (ETDEWEB)

Streitparth, F. [Klinik fuer Strahlenheilkunde, Charite, Campus Virchow-Klinikum, Humboldt-University, Berlin (Germany)], E-mail: florian.streitparth@charite.de; Schoettle, P.; Schell, H. [Center for Musculoskeletal Surgery, Charite, Campus Virchow-Klinikum, Humboldt-University, Berlin (Germany); Lehmkuhl, L.; Madej, T.; Wieners, G. [Klinik fuer Strahlenheilkunde, Charite, Campus Virchow-Klinikum, Humboldt-University, Berlin (Germany); Duda, G.N. [Center for Musculoskeletal Surgery, Charite, Campus Virchow-Klinikum, Humboldt-University, Berlin (Germany); Schroeder, R.J. [Klinik fuer Strahlenheilkunde, Charite, Campus Virchow-Klinikum, Humboldt-University, Berlin (Germany)

2009-04-15

Objective: To analyze the spectrum of findings in indirect MR-arthrography following osteochondral autograft transfer system (OATS) and crushed bone graft using a magnetic resonance imaging (MRI) scoring and grading system in relation to histology as the standard of reference. Materials and methods: Iatrogenic lesions were set at ovine condylar facets (n = 6/group), treated with OATS or crushed bone graft. 1.5 T MRI was performed 6 months after surgery using PD-weighted (w fat saturated (fs) fast spin echo (FSE), T1-w 2D, and 3D fs gradient echo (GE) sequences 30 min. after i.v. Gd-DTPA administration and passive joint exercise. The repair tissue was evaluated by two independent radiologists. The MR findings were compared to histology. Results: In all cases, MRI and histologic grading correlated well and showed significant superior repair in OATS at 6 months (p < 0.05), reproducing the original articular contour and a good subchondral restoration. FsT1-w3DGE proved most appropriate identifying characteristic post-operative findings: the OATS group demonstrated bone marrow edema at the donor site and the graft/host interface showed significant enhancement in indirect MR-arthrography, indicating fibrocartilage. After crushed bone graft, we found an irregular structure and significant contrast uptake, consistent with remnants of bone grafts surrounded by inflammatory tissue. Conclusion: Indirect MR-arthrography is an accurate, non-invasive monitoring tool following OATS and crushed bone graft as the MRI scoring and grading system allows a reliable evaluation of normal and pathological osteochondral repair with a high histologic correlation.

Mix proportioning and performance of a crushed limestone sand-concrete

OpenAIRE

Makhloufi Zoubir; Bouziani Tayeb; Bédérina Madani; Hadjoudja Mourad

2014-01-01

Satisfying the ever-growing demand of concrete aggregates poses a problem in many parts of the world due to shortage of natural sand. Moreover, to conserve natural resources and protect civil engineering infrastructures, there is a need to find alternative materials. Crushed stone sand has been identified as a potential substitute material for natural sand in making good quality concrete. The main objective of the present investigation is to determine an adequate mix design method and evaluat...

In-State and Interstate Associations Between Gun Shows and Firearm Deaths and Injuries: A Quasi-experimental Study.

Science.gov (United States)

Matthay, Ellicott C; Galin, Jessica; Rudolph, Kara E; Farkas, Kriszta; Wintemute, Garen J; Ahern, Jennifer

2017-12-19

Gun shows are an important source of firearms, but no adequately powered studies have examined whether they are associated with increases in firearm injuries. To determine whether gun shows are associated with short-term increases in local firearm injuries and whether this association differs by the state in which the gun show is held. Quasi-experimental. California. Persons in California within driving distance of gun shows. Gun shows in California and Nevada between 2005 and 2013 (n = 915 shows) and rates of firearm-related deaths, emergency department visits, and inpatient hospitalizations in California. Compared with the 2 weeks before, postshow firearm injury rates remained stable in regions near California gun shows but increased from 0.67 injuries (95% CI, 0.55 to 0.80 injuries) to 1.14 injuries (CI, 0.97 to 1.30 injuries) per 100 000 persons in regions near Nevada shows. After adjustment for seasonality and clustering, California shows were not associated with increases in local firearm injuries (rate ratio [RR], 0.99 [CI, 0.97 to 1.02]) but Nevada shows were associated with increased injuries in California (RR, 1.69 [CI, 1.16 to 2.45]). The pre-post difference was significantly higher for Nevada shows than California shows (ratio of RRs, 1.70 [CI, 1.17 to 2.47]). The Nevada association was driven by significant increases in firearm injuries from interpersonal violence (RR, 2.23 [CI, 1.01 to 4.89]) but corresponded to a small increase in absolute numbers. Nonfirearm injuries served as a negative control and were not associated with California or Nevada gun shows. Results were robust to sensitivity analyses. Firearm injuries were examined only in California, and gun show occurrence was not randomized. Gun shows in Nevada, but not California, were associated with local, short-term increases in firearm injuries in California. Differing associations for California versus Nevada gun shows may be due to California's stricter firearm regulations. National

Proposed method of producing large optical mirrors Single-point diamond crushing followed by polishing with a small-area tool

Science.gov (United States)

Wright, G.; Bryan, J. B.

1986-01-01

Faster production of large optical mirrors may result from combining single-point diamond crushing of the glass with polishing using a small area tool to smooth the surface and remove the damaged layer. Diamond crushing allows a surface contour accurate to 0.5 microns to be generated, and the small area computer-controlled polishing tool allows the surface roughness to be removed without destroying the initial contour. Final contours with an accuracy of 0.04 microns have been achieved.

Experimental study on brain injury in Beagle dogs caused by adjacent cabin explosion in warship

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Yan-teng LI

2017-04-01

Full Text Available Objective 　Through the establishment of adjacent cabin blast injury model of Beagle dog, to investigate the pathophysiological changes in the experimental animals in this scenario, then speculate on the mechanisms of injury. Methods 　Several adjacent cabins were built in the same size with the real warship. Seven Beagle dogs were subjected to injuries from the explosion, from whom one was selected randomly to implant intracranial pressure transducers before blast, the others were tested on the pathophysiological changes after blast. The dogs were mounted on the platform of a cabinet in the adjacent cabin, subjected to injury from 650g bare TNT explosive blast. The transducers recorded the value of space and intracranial shock wave pressure. Following blast treatment, the serum levels of IL -6, IL -8, neuron specific enolase (NSE, brain and chest CT and pathological changes of the brain tissue were observed. Results 　Serum levels of IL-6, IL-8 and NSE were elevated to varying degrees after blast. All of them increased significantly at different time points after blast (P<0.05. Brain and chest CT examinations did not show any significant positive results. Pathological results showed that there was a little necrosis in the brain, some neurons had karyopycnosis, karyolysis or disappearance of the nucleoli, and the cell boundaries were blurred. The blast wave was blocked greatly by the scalp and skull (about 90%, but could still penetrate them and cause brain injuries. Conclusions 　Explosion in the adjacent cabin causes mainly mild traumatic brain injuries. Blast wave can be blocked by the scalp and skull greatly. DOI: 10.11855/j.issn.0577-7402.2017.03.11

Investigation of the use of waste crushed glass in the production of asphalt mixes

CSIR Research Space (South Africa)

Anochie-Boateng, Joseph

2017-06-01

Full Text Available Recent study at the Council for Scientific and Industrial Research in South Africa has revealed the potential to substitute depleting natural aggregates with waste crushed glass in asphalt mixes. This paper presents an investigation of the use...

Investigating the swelling pressure of compacted crushed-Callovo-Oxfordian clay-stone

International Nuclear Information System (INIS)

Tang, C. S.; Tang, A. M.; Cui, Y. J.; Delage, P.; Schroeder, C.; De Laure, E.

2011-01-01

This paper presents an experimental study on the swelling pressure of heavily compacted crushed Callovo-Oxfordian (COx) clay-stone at a dry unit mass ρ d =2.0 Mg/m 3 using four different methods: constant-volume, swell-reload, zero-swell and adjusted constant-volume method. Results show that the swelling pressure varies in the range of 1-5 MPa and depends significantly on the test method. From the constant-volume tests, it is observed that the swelling behavior during wetting is a function of the suction and depends on both the hydration paths and wetting conditions (e.g. vapor-wetting or liquid-wetting). The swelling pressure decreases significantly with saturation time. To identify the microstructure changes of specimens before and after wetting, mercury intrusion porosimetry (MIP) and scanning electron microscopy (SEM) tests were performed. It is observed that, after wetting, the large inter-aggregate pores observed in the as-compacted specimen are no longer apparent; the whole pattern is characterized by a general swell of hydrated clay particles, rendering the soil more homogenous. Results from MIP indicated that wetting caused a significant reduction of the entrance diameter of the dominant inter-aggregate pores from 2.1 to 0.5μm whereas intra-aggregate pores were not significantly influenced. (authors)

Review of evaluations of crushing results for the seedbed preparation

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Siegfried Anisch

2016-06-01

Full Text Available For evaluating the work results of tillage operations today only inaccurate parameters are available which cannot be readily measured. Thus, evaluating and comparing the work results of machines and developing suitable sensors are difficult. At the Technical University of Dresden, till 1990, research projects for determining aggregate size composition of soil have been done. Based on this work, this study will show suggestions for measuring, displaying and evaluation of soil crushing results depending on tillage work conditions.

Determination of exposure to respirable quartz in the stone crushing units at Azendarian-West of Iran.

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Bahrami, Abdul Rahman; Golbabai, Faridah; Mahjub, Hossien; Qorbani, Farshid; Aliabadi, Mohsan; Barqi, Mohamadali

2008-08-01

The purpose of this study is to describe the personal exposure to respirable dust and quartz and in stone crushing units located at west of Iran. A size of 40 personal samples and 40 stationary samples were obtained and analysis was done by X-ray diffraction (XRD). The results of personal sampling were shown the concentrations of respirable dust exposure level in workers of process, hopper and drivers were 1.90, 2.22, 1.41 times greater than Occupational Safety and Health Administration permissible exposure limit (OSHA PEL). The average value of total dust and respirable dust emission from stationary sources was 9.46 mg/m(3), 1.24 mg/m(3) respectively, showing that 13.8 % of total dust is respirable. The efficiency of local exhaust ventilation (LEV) to control of particles inside of industrial units was greater than 99%. It is concluded from this research the particulate generated from stone crushing activities contain a significant amount of respirable particle. The amount of free silica in stone quartz is 85 to 97 percent that emission of particles effect to health workers. LEV has important effect in the removal of silica particles in stone crushing units. The worker of hoppers still exposed to silica more than standard limits.

Outcomes of primary repair and primary anastomosis in war-related colon injuries.

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Vertrees, Amy; Wakefield, Matthew; Pickett, Chris; Greer, Lauren; Wilson, Abralena; Gillern, Sue; Nelson, Jeffery; Aydelotte, Jayson; Stojadinovic, Alexander; Shriver, Craig

2009-05-01

The role of primary repair (PR) of modern day war-related colon injuries remains controversial. Retrospective review of medical records of combat-wounded soldiers with colon injuries sustained during March 2003 to August 2006 was conducted. Injuries were analyzed according to location: right (n = 30), transverse (n = 13), and left (n = 24) sided colon injuries. Two-tailed Fisher's Exact or chi tests were used for statistical analysis. Seventy-seven soldiers returned to Walter Reed Army Medical Center with colon injuries suffered during Operations Enduring Freedom and Iraqi Freedom. Twelve patients with minor colon injuries were excluded. The remaining 65 patients (mean age, 28 +/- 7 years) sustained 67 colon injuries from secondary blast (n = 38); gunshot (n = 27); motor vehicle crash (n = 1) and crush injury (n = 1). Patients arrived at Walter Reed Army Medical Center 5 days (range, 2-16 days) after injury and damage control operations (n = 27, 42%), and were hospitalized for a median of 22 days (range, 1-306 days). Follow-up averaged 311 days (median, 198 days). PR was attempted in right (n = 18, 60%), transverse (n = 11, 85%), and left (n = 9, 38%) sided colon injuries. Delayed definitive treatment of colon injuries occurred in 42% of patients. Failure of repair occurred in 16% of patients and was more likely with concomitant pancreatic, stomach, splenic, diaphragm, and renal injuries. Overall morbidity for ostomy closure after primary ostomy formation was 30%, but increased to 75% for ostomy closure after primary anastomotic or repair failure. PR of war-related colon injuries can be performed safely in selected circumstances in the absence of concomitant organ injury. Delayed anastomosis can often be performed after damage control operations once the patient stabilizes. Ostomy closure complications are more likely after anastomotic failure.

Recycled Asphalt Pavement and Crushed Concrete Backfill: State-of-the-Art Review and Material Characterization

Science.gov (United States)

2001-10-01

This report describes research results from the first year of a three-year study focused on the use of recycled asphalt pavement (RAP) and crushed concrete (CC) as backfill for mechanically stabilized earth (MSE) walls.

Effects of sevoflurane on ventilator induced lung injury in a healthy lung experimental model.

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Romero, A; Moreno, A; García, J; Sánchez, C; Santos, M; García, J

2016-01-01

Ventilator-induced lung injury (VILI) causes a systemic inflammatory response in tissues, with an increase in IL-1, IL-6 and TNF-α in blood and tissues. Cytoprotective effects of sevoflurane in different experimental models are well known, and this protective effect can also be observed in VILI. The objective of this study was to assess the effects of sevoflurane in VILI. A prospective, randomized, controlled study was designed. Twenty female rats were studied. The animals were mechanically ventilated, without sevoflurane in the control group and sevoflurane 3% in the treated group (SEV group). VILI was induced applying a maximal inspiratory pressure of 35 cmH2O for 20 min without any positive end-expiratory pressure for 20 min (INJURY time). The animals were then ventilated 30 min with a maximal inspiratory pressure of 12 cmH2O and 3 cmH2O positive end-expiratory pressure (time 30 min POST-INJURY), at which time the animals were euthanized and pathological and biomarkers studies were performed. Heart rate, invasive blood pressure, pH, PaO2, and PaCO2 were recorded. The lung wet-to-dry weight ratio was used as an index of lung edema. No differences were found in the blood gas analysis parameters or heart rate between the 2 groups. Blood pressure was statistically higher in the control group, but still within the normal clinical range. The percentage of pulmonary edema and concentrations of TNF-α and IL-6 in lung tissue in the SEV group were lower than in the control group. Sevoflurane attenuates VILI in a previous healthy lung in an experimental subclinical model in rats. Copyright © 2015 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

Endothelin-A receptor blockade slows the progression of renal injury in experimental renovascular disease.

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Kelsen, Silvia; Hall, John E; Chade, Alejandro R

2011-07-01

Endothelin (ET)-1, a potent renal vasoconstrictor with mitogenic properties, is upregulated by ischemia and has been shown to induce renal injury via the ET-A receptor. The potential role of ET-A blockade in chronic renovascular disease (RVD) has not, to our knowledge, been previously reported. We hypothesized that chronic ET-A receptor blockade would preserve renal hemodynamics and slow the progression of injury of the stenotic kidney in experimental RVD. Renal artery stenosis, a major cause of chronic RVD, was induced in 14 pigs and observed for 6 wk. In half of the pigs, chronic ET-A blockade was initiated (RVD+ET-A, 0.75 mg·kg(-1)·day(-1)) at the onset of RVD. Single-kidney renal blood flow, glomerular filtration rate, and perfusion were quantified in vivo after 6 wk using multidetector computer tomography. Renal microvascular density was quantified ex vivo using three-dimensional microcomputer tomography, and growth factors, inflammation, apoptosis, and fibrosis were determined in renal tissue. The degree of stenosis and increase in blood pressure were similar in RVD and RVD+ET-A pigs. Renal hemodynamics, function, and microvascular density were decreased in the stenotic kidney but preserved by ET-A blockade, accompanied by increased renal expression of vascular endothelial growth factor, hepatocyte growth factor, and downstream mediators such as phosphorilated-Akt, angiopoietins, and endothelial nitric oxide synthase. ET-A blockade also reduced renal apoptosis, inflammation, and glomerulosclerosis. This study shows that ET-A blockade slows the progression of renal injury in experimental RVD and preserves renal hemodynamics, function, and microvascular density in the stenotic kidney. These results support a role for ET-1/ET-A as a potential therapeutic target in chronic RVD.

Diffusion in crushed rock and in bentonite clay

International Nuclear Information System (INIS)

Olin, M.

1994-04-01

Diffusion theories for porous media with sorption are reviewed to serve as a basis for considering diffusion in simple systems like sand of crushed rock. A Fickian diffusion and linear sorption model is solved both by analytical Laplance transform and Green's function methods and by numerical methods, and then applied to small-scale experiments for Finnish low- and medium-level operating waste repositories. The main properties of bentonite are reviewed. The hydraulic conductivity of compacted bentonite is so low that the major transport mechanism is diffusion. A Fickian diffusion and linear sorption model is applied to bentonite. The main component of bentonite, montmorillonite, has a high ion-exchange capacity and thus, transport in bentonite consists of interactive chemical and diffusion phenomena. A chemical equilibrium model, CHEQ, is developed for ion-exchange reactions in bentonite water systems. CHEQ is applied to some bentonite experiments with success, especially for monovalent ions. The fitted log-binding constants for sodium exchange with potassium, magnesium, and calcium were 0.27, 1.50, and 2.10, respectively. A coupled chemical and diffusion model, CHEQDIFF, is developed to take account of diffusion in pore water, surface diffusion and ion-exchange reactions. The model is applied to the same experiments as CHEQ, and validation is partly successful. In the diffusion case, the above-mentioned values for binding constants are used. The apparent diffusion (both anions and cations) and surface diffusion (only for cations) constants used are 3.0*10 -11 m 2 /s and 6.0*10 -12 m 2 /s, respectively, but these values are questionable, as experimental results good enough for fitting are not available. (orig.). (74 refs., 27 figs., 12 tabs.)

Wide Spectrum of Traumatic Rhabdomyolysis in Earthquake Victims

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Shahnaz Atabak

2009-12-01

Full Text Available In the natural disasters such as earthquake, based on severity of trauma, time under the rubble and quality/quantity of hydratation we will confront with a spectrum of traumatic rhabdomyolysis. In present study we evaluate victims of Bam earthquake to show different stage of muscle trauma, from minor trauma with almost normal level of muscle enzyme to those with moderate trauma leading to crush injury and finally to advanced crush syndrome. Questionnaire consisted of clinical, biochemical and demographic items was designed and completed by our research team retrospectively. We divided the patients to crush and non-crush and also crush injury and crush syndrome, and then compared aforementioned items between them. Clinical and laboratory data of 2962 hospitalized victims, with an average age of 28.4(SD14.2 years (range 1-90 were collected (40% female. 611 patients were affected with crush injury (20%. These were entrapped 2.2 hours longer than the others (P<0.001. Mean IV intake in first 5 days was 3.6(SD2.6 liters for these patients in compare with 2.5(SD1.4 liters for others (P<0.001. 200 cases showed complete feature of crush syndrome. Electrolyte imbalance and systemic complications were drastically increased in the worst patients with crush syndrome. In approach to crushed patients of natural disasters by attention to the wide spectrum of muscle damage and systemic problems, the stepwise management protocol based on severity of traumatic rhabdomyolysis is inevitable and warranted.

Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury

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Ziebell Jenna M

2012-10-01

Full Text Available Abstract Background Since their discovery, the morphology of microglia has been interpreted to mirror their function, with ramified microglia constantly surveying the micro-environment and rapidly activating when changes occur. In 1899, Franz Nissl discovered what we now recognize as a distinct microglial activation state, microglial rod cells (Stäbchenzellen, which he observed adjacent to neurons. These rod-shaped microglia are typically found in human autopsy cases of paralysis of the insane, a disease of the pre-penicillin era, and best known today from HIV-1-infected brains. Microglial rod cells have been implicated in cortical ‘synaptic stripping’ but their exact role has remained unclear. This is due at least in part to a scarcity of experimental models. Now we have noted these rod microglia after experimental diffuse brain injury in brain regions that have an associated sensory sensitivity. Here, we describe the time course, location, and surrounding architecture associated with rod microglia following experimental diffuse traumatic brain injury (TBI. Methods Rats were subjected to a moderate midline fluid percussion injury (mFPI, which resulted in transient suppression of their righting reflex (6 to 10 min. Multiple immunohistochemistry protocols targeting microglia with Iba1 and other known microglia markers were undertaken to identify the morphological activation of microglia. Additionally, labeling with Iba1 and cell markers for neurons and astrocytes identified the architecture that surrounds these rod cells. Results We identified an abundance of Iba1-positive microglia with rod morphology in the primary sensory barrel fields (S1BF. Although present for at least 4 weeks post mFPI, they developed over the first week, peaking at 7 days post-injury. In the absence of contusion, Iba1-positive microglia appear to elongate with their processes extending from the apical and basal ends. These cells then abut one another and lay adjacent

Clinical Outcome After DK Crush Versus Culotte Stenting of Distal Left Main Bifurcation Lesions: The 3-Year Follow-Up Results of the DKCRUSH-III Study.

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Chen, Shao-Liang; Xu, Bo; Han, Ya-Ling; Sheiban, Imad; Zhang, Jun-Jie; Ye, Fei; Kwan, Tak W; Paiboon, Chitprapai; Zhou, Yu-Jie; Lv, Shu-Zheng; Dangas, George D; Xu, Ya-Wei; Wen, Shang-Yu; Hong, Lang; Zhang, Rui-Yan; Wang, Hai-Chang; Jiang, Tie-Ming; Wang, Yan; Sansoto, Teguh; Chen, Fang; Yuan, Zu-Yi; Li, Wei-Min; Leon, Martin B

2015-08-24

The present study aimed to investigate the difference in major adverse cardiac events (MACE) at 3 years after double-kissing (DK) crush versus culotte stenting for unprotected left main distal bifurcation lesions (LMDBLs). The multicenter and randomized DKCRUSH-III (Comparison of double kissing crush versus culotte stenting for unprotected distal left main bifurcation lesions: results from a multicenter, randomized, prospective study) showed that DK crush stenting was associated with fewer MACE at 1-year follow-up in patients with LMDBLs compared with culotte stenting. Here, we report the 3-year clinical outcome of the DKCRUSH-III study. A total of 419 patients with LMDBLs who were randomly assigned to either the DK crush or culotte group in the DKCRUSH-III study were followed for 3 year. The primary endpoint was the occurrence of a MACE at 3 years. Stent thrombosis (ST) was the safety endpoint. Patients were classified by simple and complex LMDBLs according to the DEFINITION (Definition and Impact of Complex Bifurcation Lesions on Clinical Outcomes After Percutaneous Coronary Intervention Using Drug-Eluting Stents) study criteria. At 3 years, MACE occurred in 49 patients the culotte group and in 17 patients in the DK crush group (cumulative event rates of 23.7% and 8.2%, respectively; p DK crush group (p = 0.007). Complex LMDBLs were associated with a higher rate of MACE (35.3%) at 3 years compared with a rate of 8.1% in patients with simple LMDBLs (p DK] Crush Versus Culotte Stenting for the Treatment of Unprotected Distal Left Main Bifurcation Lesions: DKCRUSH-III, a Multicenter Randomized Study Comparing Double-Stent Techniques; ChiCTR-TRC-11001877). Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Carpal tunnel syndrome and the "double crush" hypothesis: a review and implications for chiropractic

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Russell Brent S

2008-04-01

Full Text Available Abstract Upton and McComas claimed that most patients with carpal tunnel syndrome not only have compressive lesions at the wrist, but also show evidence of damage to cervical nerve roots. This "double crush" hypothesis has gained some popularity among chiropractors because it seems to provide a rationale for adjusting the cervical spine in treating carpal tunnel syndrome. Here I examine use of the concept by chiropractors, summarize findings from the literature, and critique several studies aimed at supporting or refuting the hypothesis. Although the hypothesis also has been applied to nerve compressions other than those leading to carpal tunnel syndrome, this discussion mainly examines the original application – "double crush" involving both cervical spinal nerve roots and the carpal tunnel. I consider several categories: experiments to create double crush syndrome in animals, case reports, literature reviews, and alternatives to the original hypothesis. A significant percentage of patients with carpal tunnel syndrome also have neck pain or cervical nerve root compression, but the relationship has not been definitively explained. The original hypothesis remains controversial and is probably not valid, at least for sensory disturbances, in carpal tunnel syndrome. However, even if the original hypothesis is importantly flawed, evaluation of multiple sites still may be valuable. The chiropractic profession should develop theoretical models to relate cervical dysfunction to carpal tunnel syndrome, and might incorporate some alternatives to the original hypothesis. I intend this review as a starting point for practitioners, educators, and students wishing to advance chiropractic concepts in this area.

[Facial nerve injuries cause changes in central nervous system microglial cells].

Science.gov (United States)

Cerón, Jeimmy; Troncoso, Julieta

2016-12-01

Our research group has described both morphological and electrophysiological changes in motor cortex pyramidal neurons associated with contralateral facial nerve injury in rats. However, little is known about those neural changes, which occur together with changes in surrounding glial cells. To characterize the effect of the unilateral facial nerve injury on microglial proliferation and activation in the primary motor cortex. We performed immunohistochemical experiments in order to detect microglial cells in brain tissue of rats with unilateral facial nerve lesion sacrificed at different times after the injury. We caused two types of lesions: reversible (by crushing, which allows functional recovery), and irreversible (by section, which produces permanent paralysis). We compared the brain tissues of control animals (without surgical intervention) and sham-operated animals with animals with lesions sacrificed at 1, 3, 7, 21 or 35 days after the injury. In primary motor cortex, the microglial cells of irreversibly injured animals showed proliferation and activation between three and seven days post-lesion. The proliferation of microglial cells in reversibly injured animals was significant only three days after the lesion. Facial nerve injury causes changes in microglial cells in the primary motor cortex. These modifications could be involved in the generation of morphological and electrophysiological changes previously described in the pyramidal neurons of primary motor cortex that command facial movements.

Can Plant-Based Natural Flax Replace Basalt and E-Glass for Fiber-Reinforced Polymer Tubular Energy Absorbers? A Comparative Study on Quasi-Static Axial Crushing

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Libo Yan

2017-12-01

Full Text Available Using plant-based natural fibers to substitute glass fibers as reinforcement of composite materials is of particular interest due to their economic, technical, and environmental significance. One potential application of plant-based natural fiber reinforced polymer (FRP composites is in automotive engineering as crushable energy absorbers. Current study experimentally investigated and compared the energy absorption efficiency of plant-based natural flax, mineral-based basalt, and glass FRP (GFRP composite tubular energy absorbers subjected to quasi-static axial crushing. The effects of number of flax fabric layer, the use of foam filler and the type of fiber materials on the crashworthiness characteristics, and energy absorption capacities were discussed. In addition, the failure mechanisms of the hollow and foam-filled flax, basalt, and GFRP tubes in quasi-static axial crushing were analyzed and compared. The test results showed that the energy absorption capabilities of both hollow and foam-filled energy absorbers made of flax were superior to the corresponding energy absorbers made of basalt and were close to energy absorbers made of glass. This study, therefore, indicated that flax fiber has the great potential to be suitable replacement of basalt and glass fibers for crushable energy absorber application.

Acute pain in an emergency clinic: latency of onset and descriptor patterns related to different injuries.

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Melzack, R; Wall, P D; Ty, T C

1982-09-01

Features of acute pain were examined in patients at an emergency clinic. Patients who had severe, life-threatening injuries or who were agitated, drunk, or 'in shock' were excluded from the study. Of 138 patients who were alert, rational and coherent, 51 (37%) stated that they did not feel pain at the time of injury. The majority of these patients reported onset of pain within an hour of injury, although the delays were as long as 9 h or more in some patients. The predominant emotions of the patients were embarrassment at appearing careless or worry about loss of wages. None expressed any pleasure or indicated any prospect of gain as a result of the injury. The occurrence of delays in pain onset was related to the nature of the injury. Of 46 patients whose injuries were limited to skin (lacerations, cuts, abrasions, burns), 53% had a pain-free period. Of 86 patients with deep-tissue injuries (fractures, sprains, bruises, amputation of a finger, stabs and crushes), only 28% had a pain-free period. The McGill Pain Questionnaire was administered to patients who felt pain immediately after injury or after a delay, and revealed a normal distribution of sensory scores but very low affective scores compared to patients with chronic pain. The results indicate that the relationship between injury and pain is highly variable and complex.

Study of the neuroprotective effects and mechanisms of Tianma Gouteng Decoction on retinal ganglion cells in rat optic nerve crush model

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Fan-Tao Lyu

2018-01-01

Full Text Available AIM: To observe the mechanism of Tianma Gouteng Decoction on the protein molecular level in the optic nerve crush model rats. METHODS: Totally 36 participants 36 male Wistar rats were divided randomly into six groups(6 in every group: normal control group, negative control group, Tianma Gouteng Decoction treatment groups(con-centrations were 0.6g/mL, 1.2g/mL, 2.4g/mL respictivelyand ginkgo biloba tablets positive control group(concentrations was 1.2mg/mL. Nothing was done in the normal control group. The optic nerve of right eye in the other groups was done with the optic nerve crush model. Normal control group and negative control group was treated only with water. The average grey scale values of the N-methyl-D-aspartic acid receptor 2B(NMDA2Breceptor protein, beta - amyloid protein(Aβin the average grey scale values were detected. RESULTS: The average grey scale value of Tianma Gouteng Decoction in low, medium and high dose groups about NMDA2B receptor protein was significantly less than that of the negative control group(all PP=0.092, 0.411, 0.676, the difference between normal control group and negative control group was significant(PP=0.030, 0.001. The low dose group than the negative control group was not obviously(P=0.614. The high dose group was not significantly different from the positive control group(P=0.927, the difference between normal control group and negative control group was significant(PCONCLUSION: Tianma Gouteng Decoction can go through the decrease of the NMDA2B receptor protein expression and the control of beta-amyloid deposition to reduce the retinal ganglion cell injury and apoptosis.

Effect of shape and surface texture of aggregates during high intensity vertical shaft impact autogeneous crushing

International Nuclear Information System (INIS)

Samayamutthirian Palaniandy; Khairun Azizi Mohd Azizli

2002-01-01

The demand for quarry industry to produce high quality aggregates is increasing parallel with the demand of high strength concrete. Focus on the high quality aggregates production is very essential as 70% of the concrete consist of aggregates. High quality aggregate is characterised according to its shape, surface texture and its size distribution. The cubical and more equidimensional aggregates are characterised as high quality aggregates. Besides photomicrograph of aggregates, Flakiness and Elongation indices are important empirical measurements to determine the quality of the aggregates. The Barmac Rock On Rock Vertical Shaft Impactor proved that the shape of the aggregates can be improved by various crushing mechanisms as the EI and FI values were low and 75% of the cubical particles were observed in the crushed aggregates. (Author)

Characterisation of extra virgin olive oils from Galician autochthonous varieties and their co-crushings with Arbequina and Picual cv.

Science.gov (United States)

Reboredo-Rodríguez, P; González-Barreiro, C; Cancho-Grande, B; Fregapane, G; Salvador, M D; Simal-Gándara, J

2015-06-01

The current trend of the olive oil market is the production of high quality extra from traditional minor olive varieties with peculiar and differentiated characteristics (especially with respect to the aromatic and phenolic composition). In this way, the interest of Galician oil producers (NW Spain) in recovering old autochthonous Local olive fruits has increased substantially in recent years. In order to investigate the potential of the Local olives by either producing high quality monovarietal oils or mixing with the most widespread olives in Galicia (Arbequina and Picual cv.), quality indices, and fatty acid composition as well as volatile and phenolic profiles were determined and compared. All EVOOs studied in this work can be considered as "extra virgin olive oil" due to quality indices fell within the ranges established in legislation. Picual and Local olive oils as well as those resulting from their co-crushing reach values which are required by EU legislation to add the specific health claim on the oil label. Co-crushing Picual:Local (80:20) provided a significant enhancement of grass and apple nuances and a decrease of banana notes with respect to Picual oils. The co-crushing process improved sensory and health properties of Picual extra virgin olive oils. The effect of co-crushing on phenolics, ester volatiles and banana nuances cannot be easily modulated, contrary to quality indices and fatty acid composition, both changing linearly in strict correlation with the fruit mass ratio. Copyright © 2014 Elsevier Ltd. All rights reserved.

Injury Surveillance and Safety Considerations for Large-Format Lead-Acid Batteries Used in Mining Applications.

Science.gov (United States)

Reyes, Miguel Angel; Novak, Thomas

2016-03-01

Large lead-acid batteries are predominantly used throughout the mining industry to power haulage, utility, and personnel-carrier vehicles. Without proper operation and maintenance, the use of these batteries can introduce mechanical and electrical hazards, particularly in the confined, and potentially dangerous, environment of an underground coal mine. A review of the Mine Safety and Health Administration accident/illness/injury database reveals that a significant number of injuries occur during the maintenance and repair of lead-acid batteries. These injuries include burns from electrical arcing and acid exposure, as well as strained muscles and crushed hands. The National Institute for Occupational Safety and Health investigated the design and implementation of these batteries to identify safety interventions that can mitigate these inherent hazards. This paper promotes practical design modifications, such as reducing the size and weight of battery assembly lids in conjunction with lift assists, as well as using five-pole cable connectors to improve safety.

The production of pig iron from crushing plant waste using hot blast cupola

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Kusno Isnugroho

2018-03-01

Full Text Available A production of pig iron has been conducted from crushing plant waste. The process of preparing pig iron was using hot blast cupola (HBC furnace which was injected with charcoal powder to improve temperature process and reduction zone in the furnace. The process was started by washing process and magnetic separation of raw material as an effort to improve iron content degree from crushing plant waste. The next process was preparing the composite pellet with the particle size of −80 + 100 mesh and with the composition of 80% iron ore, 15% wood charcoal, and 5% bentonite. The result of pellet size was 2.5–4.0 mm. The experiment was continued to reduce pellet composite in the HBC furnace. The pig iron produced from this process contained of 93.62%Fe, 3.5%C, 1.55%Si, 0.87%Mn, 0.05%P, and 0.087%S.With this result, the pig iron produced already fulfill the metallurgical specification to be used in smelting industry. Keywords: Pig iron, Pellet, Injection, Charcoal, Hot blast cupola

Volume reduction and plutonium recovery in alpha wastes by cryogenic crushing and lixiviation

International Nuclear Information System (INIS)

Arnal, T.; Pajot, J.

1986-06-01

The industry of plutonium generates solid alpha wastes of medium activity called ''technological wastes''. They are mainly produced during the fabrication and reprocessing of nuclear reactor fuels and they are of a wide variety i.e: vinyl bags, gloves, glass, steel materials used in glove box operation, etc... These wastes contain relevant residual quantities of uranium and plutonium in the form of oxides or nitrates, reaching up to several dozen grams per cubic meter. Up to the beginning of the eighties, they were conditionned without any treatment and stored as such on the production site. However, for an economic and safe storage, recovering of the plutonium contained in these waste streams and reduction of their volume is of obvious importance. At the plutonium ''Complexe de Fabrication des Combustibles de Cadarache'' was developed a new technical solution of this problem that combines cryogenic crushing of the solid waste and plutonium recovery from the crushed material by chemical lixiviation. The first results obtained in applying this system on the industrial scale are reported briefly

Clay modified crushed salt for shaft sealing elements. Material optimization and evaluation in field tests

Energy Technology Data Exchange (ETDEWEB)

Glaubach, Uwe; Hofmann, Martin; Gruner, Matthias; Kudla, Wolfram [TU Bergakademie Freiberg (Germany). Inst. of Mining and Special Civil Engineering

2015-07-01

Salt-based materials are intended to use for backfill and sealing systems in geotechnical barriers in underground HLW-repositories. Due to the creep of the saliniferous host rock, the salt backfill will be compacted during several hundreds or thousands years of operation to a minimum of porosity resp. permeability. To raise the sealing potential of a salt-based backfill, the porosity after construction should be minimized by optimal material performance and compaction performance. A procedure to optimize the grain size distribution of crushed salt and its water and clay content is described. The optimized salt fraction gets a better compaction behavior than straight mine-run salt. The addition of a filler-like material (e.g. Friedland Clay Powder) reduces the total porosity and permeability. Backfill columns made from crushed salt and clay probably include an instant sealing function.

Evaluation of the Effects of Crushed and Expanded Waste Glass Aggregates on the Material Properties of Lightweight Concrete Using Image-Based Approaches.

Science.gov (United States)

Chung, Sang-Yeop; Abd Elrahman, Mohamed; Sikora, Pawel; Rucinska, Teresa; Horszczaruk, Elzbieta; Stephan, Dietmar

2017-11-25

Recently, the recycling of waste glass has become a worldwide issue in the reduction of waste and energy consumption. Waste glass can be utilized in construction materials, and understanding its effects on material properties is crucial in developing advanced materials. In this study, recycled crushed and expanded glasses are used as lightweight aggregates for concrete, and their relation to the material characteristics and properties is investigated using several approaches. Lightweight concrete specimens containing only crushed and expanded waste glass as fine aggregates are produced, and their pore and structural characteristics are examined using image-based methods, such as scanning electron microscopy (SEM), X-ray computed tomography (CT), and automated image analysis (RapidAir). The thermal properties of the materials are measured using both Hot Disk and ISOMET devices to enhance measurement accuracy. Mechanical properties are also evaluated, and the correlation between material characteristics and properties is evaluated. As a control group, a concrete specimen with natural fine sand is prepared, and its characteristics are compared with those of the specimens containing crushed and expanded waste glass aggregates. The obtained results support the usability of crushed and expanded waste glass aggregates as alternative lightweight aggregates.

Evaluation of the Effects of Crushed and Expanded Waste Glass Aggregates on the Material Properties of Lightweight Concrete Using Image-Based Approaches

Directory of Open Access Journals (Sweden)

Sang-Yeop Chung

2017-11-01

Full Text Available Recently, the recycling of waste glass has become a worldwide issue in the reduction of waste and energy consumption. Waste glass can be utilized in construction materials, and understanding its effects on material properties is crucial in developing advanced materials. In this study, recycled crushed and expanded glasses are used as lightweight aggregates for concrete, and their relation to the material characteristics and properties is investigated using several approaches. Lightweight concrete specimens containing only crushed and expanded waste glass as fine aggregates are produced, and their pore and structural characteristics are examined using image-based methods, such as scanning electron microscopy (SEM, X-ray computed tomography (CT, and automated image analysis (RapidAir. The thermal properties of the materials are measured using both Hot Disk and ISOMET devices to enhance measurement accuracy. Mechanical properties are also evaluated, and the correlation between material characteristics and properties is evaluated. As a control group, a concrete specimen with natural fine sand is prepared, and its characteristics are compared with those of the specimens containing crushed and expanded waste glass aggregates. The obtained results support the usability of crushed and expanded waste glass aggregates as alternative lightweight aggregates.

Impact of crushed mineral aggregate on the pumpability of concrete during transport and placement

Directory of Open Access Journals (Sweden)

Topličić-Ćurčić Gordana

2016-01-01

Full Text Available In the spirit of the sustainable buildings, and with the goal of protection of river courses, in the near future an already announced directive ordering closing down of a large number of river aggregate dredging operations will be adopted. For that reason, usage of crushed mineral aggregate in concrete mixes is increasing. Irrespective of downsides of the fined crushed mineral aggregate, such as the presence of fine particles bordering the upper permissible limit and the unfavorable shape of the grain of the course aggregate for obtaining liquid consistency required for the pumpable concrete, the demanded pumpability of concrete during transport and placement has been achieved. By adding admixtures to concrete, the required concrete properties, such as: frost resistance, simultaneous frost and salt resistance and water tightness have been achieved. [Projekat Ministarstva nauke Republike Srbije, br. TR 36017: Utilization of by - products and recycled waste materials in concrete composites in the scope of sustainable construction development in Serbia: investigation and environmental assessment of possible applications

IMPACT OF ROCK HARDNESS ON FRAGMENTATION BY HYDRAULIC HAMMER AND CRUSHING IN JAW CRUSHER

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Trpimir Kujundžić

2008-12-01

Full Text Available The physical and mechanical characteristics of intact rocks depend on the way of their formation, sustained deformations and the process of wearing a specific rock has been exposed to. These characteristics have a rather high influence on the technological process of extraction and dressing of mineral raw materials. However, the mechanical characteristics of rocks due to use of explosives for their extraction in the open pit have a more significant impact. The rock blocks extracted by blasting which are larger than the opening of the primary crusher are usually fragmented by hydraulic hammer. The paper presents the results of the testing of impact of rock hardness on fragmentation of rocks by means of hydraulic hammer and during crushing in jaw crusher. The testing was carried out on the rock samples from five quarries. According to the obtained results the hardness has a considerably larger impact on the fragmentation energy by hydraulic hammer than on the crushing energy in jaw crusher.

Evaluation of steel slag and crushed limestone mixtures as subbase material in flexible pavement

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Ahmed Ebrahim Abu El-Maaty Behiry

2013-03-01

Full Text Available Steel slag is produced as a by-product during the oxidation of steel pellets in an electric arc furnace. This by-product that mainly consists of calcium carbonate is broken down to smaller sizes to be used as aggregates in pavement layers. They are particularly useful in areas where a good-quality aggregate is scarce. This research study was conducted to evaluate the effect of quantity of steel slag on the mechanical properties of blended mixes with crushed limestone aggregates, which used as subbase material in Egypt. Moreover, a theoretical analysis was employed to estimate the resistance for failure factors such as vertical deformations, vertical and radial stresses and vertical strains of subbase under overweight trucks loads. These loads cause severe deterioration to the pavement and thus reduce its life. The results indicated that the mechanical characteristics, and the resistance factors were improved by adding steel slag to the crushed limestone.

EXPERIMENTAL STUDIES ON THE QUASI-STATIC AXIAL CRUSHING BEHAVIOR OF FOAM-FILLED STEEL EXTRUSION TUBES

OpenAIRE

AL EMRAN ISMAIL

2010-01-01

The concerns of automotive safety have been given special attention in order to reduce human fatalities or injuries. One of the techniques to reduce collision impact or compression energy is by filling polymeric foam into metallic tubes. In this work, polyurethane foam was introduced into the steel extrusion tubes and quasi-statically compressed at constant cross-head displacement. Different tube thicknesses and foam densities were used and these parameters were related to the crashwor...

Brain injuries from blast.

Science.gov (United States)

Bass, Cameron R; Panzer, Matthew B; Rafaels, Karen A; Wood, Garrett; Shridharani, Jay; Capehart, Bruce

2012-01-01

Traumatic brain injury (TBI) from blast produces a number of conundrums. This review focuses on five fundamental questions including: (1) What are the physical correlates for blast TBI in humans? (2) Why is there limited evidence of traditional pulmonary injury from blast in current military field epidemiology? (3) What are the primary blast brain injury mechanisms in humans? (4) If TBI can present with clinical symptoms similar to those of Post-Traumatic Stress Disorder (PTSD), how do we clinically differentiate blast TBI from PTSD and other psychiatric conditions? (5) How do we scale experimental animal models to human response? The preponderance of the evidence from a combination of clinical practice and experimental models suggests that blast TBI from direct blast exposure occurs on the modern battlefield. Progress has been made in establishing injury risk functions in terms of blast overpressure time histories, and there is strong experimental evidence in animal models that mild brain injuries occur at blast intensities that are similar to the pulmonary injury threshold. Enhanced thoracic protection from ballistic protective body armor likely plays a role in the occurrence of blast TBI by preventing lung injuries at blast intensities that could cause TBI. Principal areas of uncertainty include the need for a more comprehensive injury assessment for mild blast injuries in humans, an improved understanding of blast TBI pathophysiology of blast TBI in animal models and humans, the relationship between clinical manifestations of PTSD and mild TBI from blunt or blast trauma including possible synergistic effects, and scaling between animals models and human exposure to blasts in wartime and terrorist attacks. Experimental methodologies, including location of the animal model relative to the shock or blast source, should be carefully designed to provide a realistic blast experiment with conditions comparable to blasts on humans. If traditional blast scaling is

Whole and crushed nutlets of chia (Salvia hispanica from Mexico as a source of functional gums

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Maira Segura-Campos

2014-12-01

Full Text Available The objective of this study was to characterize the chemical and functional properties of Mexican chia (Salvia hispanica gums extracted from defatted whole and crushed nutlets using the Soxhlet and SFE-CO2 methods. Chia gums have interesting chemical and functional properties for the food industry. The oil and gum yields were in the range of 1.98-16.42% and 5.81-12.60%, respectively. The defatting procedure did not affect significantly the oil and gum extraction; the nutlet type (whole or crushed was the only parameter influencing the yield. The proximate composition and the protein and fiber contents of chia gum were evaluated. Low contents of protein and fiber and high NFE levels were found in whole nutlet gums. The functional properties of chia gum extracted from whole and crushed nutlets with the Soxhlet and SFE-COs methods showed the following ranges of water absorption capacity of 62.64 to 143.66 g/g, water adsorption capacity of 0.69 to 1.35 g/g, and water and oil holding capacity of 100 to 149.28 g/g and19.5 to 40.4 g/g, respectively. The rheological behavior exhibited by the gums was pseudoplastic or shear thinning. From a functional perspective, chia gum is an important food component due its emulsifier and stabilizer potentials.

BAMOS: A recording application for BAsso MOuse scale of locomotion in experimental models of spinal cord injury.

Science.gov (United States)

Gómez, Alberto; Nieto-Díaz, Manuel; Del Águila, Ángela; Arias, Enrique

2018-05-01

Transparency in science is increasingly a hot topic. Scientists are required to show not only results but also evidence of how they have achieved these results. In experimental studies of spinal cord injury, there are a number of standardized tests, such as the Basso-Beattie-Bresnahan locomotor rating scale for rats and Basso Mouse Scale for mice, which researchers use to study the pathophysiology of spinal cord injury and to evaluate the effects of experimental therapies. Although the standardized data from the Basso-Beattie-Bresnahan locomotor rating scale and the Basso Mouse Scale are particularly suited for storage and sharing in databases, systems of data acquisition and repositories are still lacking. To the best of our knowledge, both tests are usually conducted manually, with the data being recorded on a paper form, which may be documented with video recordings, before the data is transferred to a spreadsheet for analysis. The data thus obtained is used to compute global scores, which is the information that usually appears in publications, with a wealth of information being omitted. This information may be relevant to understand locomotion deficits or recovery, or even important aspects of the treatment effects. Therefore, this paper presents a mobile application to record and share Basso Mouse Scale tests, meeting the following criteria: i) user-friendly; ii) few hardware requirements (only a smartphone or tablet with a camera running under Android Operating System); and iii) based on open source software such as SQLite, XML, Java, Android Studio and Android SDK. The BAMOS app can be downloaded and installed from the Google Market repository and the app code is available at the GitHub repository. The BAMOS app demonstrates that mobile technology constitutes an opportunity to develop tools for aiding spinal cord injury scientists in recording and sharing experimental data. Copyright © 2018 Elsevier Ltd. All rights reserved.

Performances of hydrated cement treated crushed rock base for Western Australian roads

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Suphat Chummuneerat

2014-12-01

Full Text Available The resilient modulus (RM of hydrated cement treated crushed rock base (HCTCRB affected by amount of hydration periods, compaction and dryback processes was presented using repeated load triaxial tests. The related trends of RM corresponding to the different hydration periods still cannot be concluded. Instead, It is found that the moisture content plays more major influence on the RM performance. Higher additional water during compaction of HCTCRB, even at its optimum moisture content and induced higher dry density, led to the inferior RM performance compared to the sample without water addition. The RM of damper samples can be improved through dryback process and superior to that of the sample without water addition at the same moisture content. However, the samples without water addition during compaction deliver the comparable RM values even its dry density is lower than the other two types. These results indicate the significant influence of moisture content to the performances of HCTCRB with regardless of the dry density. Finally, the experimental results of HCTCRB and parent material are evaluated with the K-θ model and the model recommended by Austroads. These two models provide the excellent fit of the tested results with high degree of determination.

Development of a Crush and Mix Machine for Composite Brick Fabrication

International Nuclear Information System (INIS)

Sothea, Kruy; Fazli, Nik; Hamdi, M.; Aoyama, Hideki

2011-01-01

Currently, people are more and more concerned about the environmental protection. Municipal solid wastes (MSW) have bad effect on the environment and also human health. In addition, the amounts of municipal solid wastes are increasing due to the economic development, density of population, especially in the developing countries and they are recycled in a little percentage. To address this problem, the composite brick forming machine was designed and developed to make brick using combination of MSW and mortar. The machine consists of two independent parts, crusher and mixer part, and molding part. This paper explores the design of crusher and mixer part. The crusher has ability to cut MSW such as wood, paper and plastic into small size. There are two mixers; one is used for making mortar and other use for making slurry. FEA analyses were carried out to address the suitable strength of the critical parts of the crusher which ensures that crusher can run properly with high efficiency. The experimentation of the crusher shows that it has high performance for cutting MSW. The mixers also work very well in high efficiency. The results of composite brick testing have been shown that ability of the machine can performance well. This is the innovation of crush and mix machine which is portable and economic by using MSW in replacement of sand.

Activation of α7 nicotinic acetylcholine receptor decreases on-site mortality in crush syndrome through insulin signaling-Na/K-ATPase pathway

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Bo-Shi eFan

2016-03-01

Full Text Available On-site mortality in crush syndrome remains high due to lack of effective drugs based on definite diagnosis. Anisodamine is widely used in China for treatment of shock, and activation of α7 nicotinic acetylcholine receptor (α7nAChR mediates such antishock effect. The present work was designed to test whether activation of α7nAChR with anisodamine decreased mortality in crush syndrome shortly after decompression. Sprague-Dawley rats and C57BL/6 mice with crush syndrome were injected with anisodamine (20 mg/kg and 28 mg/kg respectively, i.p. 30 min before decompression. Survival time, serum potassium, insulin, and glucose levels were observed shortly after decompression. Involvement of α7nAChR was verified with methyllycaconitine (selective α7nAChR antagonist and PNU282987 (selective α7nAChR agonist, or in α7nAChR knockout mice. Effect of anisodamine was also appraised in C2C12 myotubes. Anisodamine reduced mortality and serum potassium and enhanced insulin sensitivity shortly after decompression in animals with crush syndrome, and PNU282987 exerted similar effects. Such effects were counteracted by methyllycaconitine or in α7nAChR knockout mice. Mortality and serum potassium in rats with hyperkalemia were also reduced by anisodamine. Phosphorylation of Na/K-ATPase was enhanced by anisodamine in C2C12 myotubes. Inhibition of tyrosine kinase on insulin receptor, phosphoinositide 3-kinase, mammalian target of rapamycin, signal transducer and activator of transcription 3, and Na/K-ATPase counteracted the effect of anisodamine on extracellular potassium. These findings demonstrated that activation of α7nAChR could decrease on-site mortality in crush syndrome, at least in part based on the decline of serum potassium through insulin signaling-Na/K-ATPase pathway.

Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration.

Science.gov (United States)

Wong, Kah-Hui; Kanagasabapathy, Gowri; Naidu, Murali; David, Pamela; Sabaratnam, Vikineswary

2016-10-01

To study the ability of aqueous extract of Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats. Aqueous extract of Hericium erinaceus was given by daily oral administration following peroneal nerve crush injury in Sprague-Dawley rats. The expression of protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) signaling pathways; and c-Jun and c-Fos genes were studied in dorsal root ganglia (DRG) whereas the activity of protein synthesis was assessed in peroneal nerves by immunohistochemical method. Peripheral nerve injury leads to changes at the axonal site of injury and remotely located DRG containing cell bodies of sensory afferent neurons. Immunofluorescence studies showed that DRG neurons ipsilateral to the crush injury in rats of treated groups expressed higher immunoreactivities for Akt, MAPK, c-Jun and c-Fos as compared with negative control group (P <0.05). The intensity of nuclear ribonucleoprotein in the distal segments of crushed nerves of treated groups was significantly higher than in the negative control group (P <0.05). H. erinaceus is capable of promoting peripheral nerve regeneration after injury. Potential signaling pathways include Akt, MAPK, c-Jun, and c-Fos, and protein synthesis have been shown to be involved in its action.

Analysis of Health Data from Ten Years of Polaris Submarine Patrols

Science.gov (United States)

1979-01-01

34’ Crush injury, calf 3 3 ;;" Crush injury, foot 7 7 ’’ 1 Knees, stiff 2 2 Tendonitis, achilles 3 3 Talo fibular lig., tear 2 2 1 Myositis 1 1...Spencer. 1971. Chronic CO. toxicity: species difference physiological and histopathological effects. NSMRL Rep. No, 656. Schaefer, K. E.. S. Pasquale, A

The crush and spray: a patented design for herbicide application with less waste

Science.gov (United States)

Cherie LeBlanc Fisher; Adam H. Wiese

2009-01-01

The USDA Forest Service recently patented an equipment design to deliver herbicides more efficiently and cost-effectively. Towed by a standard all-terrain vehicle, the Crush and Spray can access out-of-the-way or wet locations. An adjustable roller first knocks down the unwanted plants. A low-set spray boom with wide angle sprayer nozzles then provides precise, close-...

Granulocyte Colony-Stimulating Factor Combined with Methylprednisolone Improves Functional Outcomes in Rats with Experimental Acute Spinal Cord Injury

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William Gemio Jacobsen Teixeira

2018-02-01

Full Text Available OBJECTIVES: To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS: Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treatment; G-CSF (G-CSF at the time of injury and daily over the next five days; methylprednisolone (methylprednisolone for 24 h; and G-CSF/Methylprednisolone (methylprednisolone for 24 h and G-CSF at the time of injury and daily over the next five days. Functional evaluation was performed using the Basso, Beattie and Bresnahan score on days 2, 7, 14, 21, 28, 35 and 42 following injury. Motor-evoked potentials were evaluated. Histological examination of the spinal cord lesion was performed immediately after euthanasia on day 42. RESULTS: Eight animals were excluded (2 from each group due to infection, a normal Basso, Beattie and Bresnahan score at their first evaluation, or autophagy, and 32 were evaluated. The combination of methylprednisolone and G-CSF promoted greater functional improvement than methylprednisolone or G-CSF alone (p<0.001. This combination also exhibited a synergistic effect, with improvements in hyperemia and cellular infiltration at the injury site (p<0.001. The groups displayed no neurophysiological differences (latency p=0.85; amplitude p=0.75. CONCLUSION: Methylprednisolone plus G-CSF promotes functional and histological improvements superior to those achieved by either of these drugs alone when treating spinal cord contusion injuries in rats. Combining the two drugs did have a synergistic effect.

Engrafted human induced pluripotent stem cell-derived anterior specified neural progenitors protect the rat crushed optic nerve.

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Leila Satarian

Full Text Available BACKGROUND: Degeneration of retinal ganglion cells (RGCs is a common occurrence in several eye diseases. This study examined the functional improvement and protection of host RGCs in addition to the survival, integration and neuronal differentiation capabilities of anterior specified neural progenitors (NPs following intravitreal transplantation. METHODOLOGY/PRINCIPAL FINDINGS: NPs were produced under defined conditions from human induced pluripotent stem cells (hiPSCs and transplanted into rats whose optic nerves have been crushed (ONC. hiPSCs were induced to differentiate into anterior specified NPs by the use of Noggin and retinoic acid. The hiPSC-NPs were labeled by green fluorescent protein or a fluorescent tracer 1,1' -dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI and injected two days after induction of ONC in hooded rats. Functional analysis according to visual evoked potential recordings showed significant amplitude recovery in animals transplanted with hiPSC-NPs. Retrograde labeling by an intra-collicular DiI injection showed significantly higher numbers of RGCs and spared axons in ONC rats treated with hiPSC-NPs or their conditioned medium (CM. The analysis of CM of hiPSC-NPs showed the secretion of ciliary neurotrophic factor, basic fibroblast growth factor, and insulin-like growth factor. Optic nerve of cell transplanted groups also had increased GAP43 immunoreactivity and myelin staining by FluoroMyelin™ which imply for protection of axons and myelin. At 60 days post-transplantation hiPSC-NPs were integrated into the ganglion cell layer of the retina and expressed neuronal markers. CONCLUSIONS/SIGNIFICANCE: The transplantation of anterior specified NPs may improve optic nerve injury through neuroprotection and differentiation into neuronal lineages. These NPs possibly provide a promising new therapeutic approach for traumatic optic nerve injuries and loss of RGCs caused by other diseases.

Experimental and Analytical Evaluation of a Composite Honeycomb Deployable Energy Absorber

Science.gov (United States)

Jackson, Karen E.; Kellas, Sotiris; Horta, Lucas G.; Annett, Martin S.; Polanco, Michael A.; Littell, Justin D.; Fasanella, Edwin L.

2011-01-01

In 2006, the NASA Subsonic Rotary Wing Aeronautics Program sponsored the experimental and analytical evaluation of an externally deployable composite honeycomb structure that is designed to attenuate impact energy during helicopter crashes. The concept, which is designated the Deployable Energy Absorber (DEA), utilizes an expandable Kevlar honeycomb structure to dissipate kinetic energy through crushing. The DEA incorporates a unique flexible hinge design that allows the honeycomb to be packaged and stowed flat until needed for deployment. A variety of deployment options such as linear, radial, and/or hybrid methods can be used. Experimental evaluation of the DEA utilized a building block approach that included material characterization testing of its constituent, Kevlar -129 fabric/epoxy, and flexural testing of single hexagonal cells. In addition, the energy attenuation capabilities of the DEA were demonstrated through multi-cell component dynamic crush tests, and vertical drop tests of a composite fuselage section, retrofitted with DEA blocks, onto concrete, water, and soft soil. During each stage of the DEA evaluation process, finite element models of the test articles were developed and simulations were performed using the explicit, nonlinear transient dynamic finite element code, LS-DYNA. This report documents the results of the experimental evaluation that was conducted to assess the energy absorption capabilities of the DEA.

Laboratory investigation of crushed salt consolidation and fracture healing

International Nuclear Information System (INIS)

1987-01-01

A laboratory test program was conducted to investigate the consolidation behavior of crushed salt and fracture healing in natural and artificial salt. Crushed salt is proposed for use as backfill in a nuclear waste repository in salt. Artificial block salt is proposed for use in sealing a repository. Four consolidation tests were conducted in a hydrostatic pressure vessel at a maximum pressure of 2500 psi (17.2 MPa) and at room temperature. Three 1-month tests were conducted on salt obtained from the Waste Isolation Pilot Plant and one 2-month test was conducted on salt from Avery Island. Permeability was obtained using argon and either a steady-state or transient method. Initial porosities ranged from 0.26 to 0.36 and initial permeabilities from 2000 to 50,000 md. Final porosities and permeabilities ranged from 0.05 to 0.19 and from -5 md to 110 md, respectively. The lowest final porosity (0.05) and permeability ( -5 md) were obtained in a 1-month test in which 2.3% moisture was added to the salt at the beginning of the test. The consolidation rate was much more rapid than in any of the dry salt tests. The fracture healing program included 20 permeability tests conducted on fractured and unfractured samples. The tests were conducted in a Hoek cell at hydrostatic pressures up to 3000 psi (20.6 MPa) with durations up to 8 days. For the natural rock salt tested, permeability was strongly dependent on confining pressure and time. The effect of confining pressure was much weaker in the artificial salt. In most cases the combined effects of time and pressure were to reduce the permeability of fractured samples to the same order of magnitude (or less) as the permeability measured prior to fracturing

Cerebral Vascular Injury in Traumatic Brain Injury.

Science.gov (United States)

Kenney, Kimbra; Amyot, Franck; Haber, Margalit; Pronger, Angela; Bogoslovsky, Tanya; Moore, Carol; Diaz-Arrastia, Ramon

2016-01-01

Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, feature after traumatic brain injury (TBI). It is likely responsible, at least in part, for functional deficits and TBI-related chronic disability. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature is a component of the neurovascular unit (NVU) coupling neuronal metabolism with local cerebral blood flow. The NVU participates in the pathogenesis of TBI, either directly from physical trauma or as part of the cascade of secondary injury that occurs after TBI. Pathologically, there is extensive cerebral microvascular injury in humans and experimental animal, identified with either conventional light microscopy or ultrastructural examination. It is seen in acute and chronic TBI, and even described in chronic traumatic encephalopathy (CTE). Non-invasive, physiologic measures of cerebral microvascular function show dysfunction after TBI in humans and experimental animal models of TBI. These include imaging sequences (MRI-ASL), Transcranial Doppler (TCD), and Near InfraRed Spectroscopy (NIRS). Understanding the pathophysiology of TCVI, a relatively under-studied component of TBI, has promise for the development of novel therapies for TBI. Published by Elsevier Inc.

Direct 40Ar/39Ar age determination of fluid inclusions using in-vacuo¬ stepwise crushing - Example of garnet from the Cycladic Blueschist Unit on Syros

Science.gov (United States)

Uunk, Bertram; Postma, Onno; Wijbrans, Jan; Brouwer, Fraukje

2017-04-01

Metamorphic minerals and veins commonly trap attending hydrous fluids in fluid inclusions, which yield a wealth of information on the history of the hosting metamorphic system. When these fluids are sufficiently saline, the KCl in the inclusions can be used as a K/Ar geochronologic system, potentially dating inclusion incorporation. Whilst primary fluid inclusions (PFIs) can date fluid incorporation during mineral or vein growth, secondary fluid inclusion trails (SFIs) can provide age constraints on later fluid flow events. At VU Amsterdam, a new in-vacuo crushing apparatus has been designed to extract fluid inclusions from minerals for 40Ar/39Ar analysis. Separates are crushed inside a crusher tube connected to a purification line and a quadrupole mass spectrometer. In-vacuo crushing is achieved by lifting and dropping a steel pestle using an externally controlled magnetic field. As the gas can be analyzed between different crushing steps, the setup permits stepwise crushing experiments. Additionally, crushed powder can be heated by inserting the crusher tube in an externally controlled furnace. Dating by 40Ar/39Ar stepwise crushing has the added advantage that, during neutron irradiation to produce 39Ar from 39K, 38Ar and 37Ar are also produced from 38Cl and 40Ca, respectively. Simultaneous analysis of these argon isotopes permits constraining the chemistry of the argon source sampled during the experiment. This allows a distinction between different fluid or crystal lattice sources. Garnet from three samples of the HP metamorphic Cycladic Blueschist Unit on Syros, Greece was stepwise crushed to obtain fluid inclusion ages. Initial steps for all three experiments yield significant components of excess argon, which are interpreted to originate from grain boundary fluids and secondary fluid inclusions trails. During subsequent steps, age results stabilize to a plateau age. One garnet from North Syros yields an unusually old 80 Ma plateau age. However, isochrons

Enhanced synthesis and secretion of apolipoprotein E from sciatic nerves of streptozotocin-induced diabetic rats after injury

International Nuclear Information System (INIS)

Ishibashi, S.; Yamada, N.; Oka, Y.

1988-01-01

To elucidate the pathogenesis of diabetic neuropathy, synthesis and secretion of apolipoprotein E (apo E) from sciatic nerves after injury was studied in normal and streptozotocin-induced diabetic rats. Seven, 14, 28, 45 and 59 days after making crush injury on sciatic nerves with concomitant administration of streptozotocin (50 mg/kg body weight), the nerves were taken out and incubated with [ 35 S]methionine. The [ 35 S]labeled apo E was precipitated with specific antiserum. The amounts of apo E secreted into medium by nerves of diabetic rats were 7 times greater than those of non-diabetic rats 7 days after injury. This enhanced secretion of apo E was relatively selective for this protein, since the ratio of the immunoprecipitable apo E to the TCA preciptitable protein in the medium increased in diabetic rats. Intriguing possibility deduced from these results is that the secretion of apo E is involved in the development of diabetic neuropathy

The scintigraphic diagnosis and follow-up of injuries to the epiphyseal plates

International Nuclear Information System (INIS)

Walter, E.; Feine, U.; Anger, K.; Schweizer, P.; Neugebauer, W.; Tuebingen Univ.; Tuebingen Univ.

1980-01-01

Injuries to the epiphysel plates without involvement of the epiphyses or metaphyses, such as crush fractures or pure epiphysiolysis may be difficult to diagnose radiologically. Thirteen bone scans after damage to the growth plate have been performed on eight children. These indicate that these scans are able to diagnose lesions of the epiphyseal plates at an early stage and with certainty. The scintigrams also provide information concerning the healing process of the plate; they indicate when healing has been completed and when the extremity can be used for weight-bearing again. Radiation exposure of the children during scintigraphy with sub(99m)Tc-polyphosphate is within acceptable limits. (orig.) [de

The role of door orientation on occupant injury in a nearside impact: a CIREN, MADYMO modeling and experimental study.

Science.gov (United States)

Tencer, Allan F; Kaufman, Robert; Huber, Philippe; Mock, Charles

2005-12-01

This study addressed the effects of vehicle height mismatch in side impact crashes. A light truck or SUV tends to strike the door of a passenger car higher causing the upper border to lead into the occupant space. Conversely, an impact centered lower on the door, from a passenger car, causes the lower border to lead. We proposed the hypothesis that the type of injury sustained by the occupant could be related to door orientation during its intrusion into the passenger compartment. Data on door orientation and nearside occupant injuries were collected from 125 side impact crashes reported in the CIREN database. Experimental testing was performed using a pendulum carrying a frame and a vehicle door, impacting against a USDOT SID. The frame allowed the door orientation to be changed. A model was developed in MADYMO (v 6.2) using the more biofidelic dummies, BIOSID, and SIDIIs as well as USDOT SID. In side impact crashes with the lower border of the door leading, 81% of occupants sustained pelvic injury, 42% suffered rib fractures, and the rate of organ injury was 0.84. With the upper border leading, 46% of occupants sustained pelvic injury, 71% sustained rib fracture, and the rate of organ injuries per case increased to 1.13. The differences in the groups with respect to pelvic injury were significant at p = 0.01, rib fracture, p = 0.10, and organ injury, p = 0.001. Experimental testing showed that when the door angle changed from lower to upper border leading, peak T4 acceleration increased by 273% and pelvic acceleration decreased by 44%. The model demonstrated that when the door angle changed from lower to upper border leading, the USDOT SID showed a 29% increase in T4 acceleration and a 57% decrease in pelvic acceleration. The BIOSID dummy demonstrated a 36% increase in T1 acceleration, a 44% increase in abdominal rib 1 deflection, a 91% increase in thoracic rib 1 deflection, and a 33% decrease in pelvic acceleration. These data add more insight to the problem of

Application of time-domain reflectometry to monitoring conditions in crushed tuff test plots at Los Alamos, New Mexico: Interpretation and recommendations for landfill monitoring

International Nuclear Information System (INIS)

Filippone, C.L.; Schofield, T.G.

1994-08-01

Horizontal and vertical measurements of moisture content were obtained daily using time domain reflectometry (TDR) at four sites in two crushed tuff experimental plots over a period of 287 days. Moisture contents were also measured weekly at the same locations and at two additional locations in the plots using the neutron probe method. Results are assessed to determine the influence of waveguide length and waveguide orientation on TDR moisture content measurements, the degree of spatial variability in measured moisture content in this engineered porous material, and the ability of TDR to resolve vertical moisture content gradients. Recommendations are made for TDR instrumentation of mixed waste landfill monitoring systems

Pre-treatment of Biomass By Rolling - A Combined Experimental and Numerical Analysis

DEFF Research Database (Denmark)

Hansen, Klaus Schütt; Ravn, Christian; Nielsen, Emil Krabbe

2017-01-01

Pre-treatment of bulk straw material by rolling is studied as a possible method to prepare for subsequent biogas production. A combined experimental and theoretical study is presented. A pilot rolling mill with a double screw feeder is designed and constructed for crushing of bulk straw. Experime...... process window for pre-treatment of wheat straw by roll pressing varying the feed, the roll gap, the roll speed and the moisture content of the bulk straw.......Pre-treatment of bulk straw material by rolling is studied as a possible method to prepare for subsequent biogas production. A combined experimental and theoretical study is presented. A pilot rolling mill with a double screw feeder is designed and constructed for crushing of bulk straw....... Experiments show that the roll speed and the roll reduction should be chosen within a specific range depending on the injection screw speed to avoid blocking or insufficient compaction. A mechanical testing procedure of the bulk straw material including closed die compaction testing as well as simple...

Study of the fracture behavior of mortar and concretes with crushed rock or pebble aggregates

Directory of Open Access Journals (Sweden)

Sebastião Ribeiro

2011-03-01

Full Text Available The objective of this work was to compare the fracture energy of mortar and concretes produced with crushed rock and pebble aggregates using zero, 10, 20, 30 and 40% of aggregates mixed with standard mortar and applying the wedge splitting method to achieve stable crack propagation. The samples were cast in a special mold and cured for 28 days, after which they were subjected to crack propagation tests by the wedge splitting method to determine the fracture energies of the mortar and concrete. The concretes showed higher fracture energy than the mortar, and the concretes containing crushed rock showed higher resistance to crack propagation than all the compositions containing pebbles. The fracture energy varied from 38 to 55 J.m-2. A comparison of the number of aggregates that separated from the two concrete matrices with the highest fracture energies indicated that the concrete containing pebbles crumbled more easily and was therefore less resistant to crack propagation.

Coupling of Mechanical Behavior of Lithium Ion Cells to Electrochemical-Thermal Models for Battery Crush; NREL (National Renewable Energy Laboratory)

Energy Technology Data Exchange (ETDEWEB)

Pesaran, Ahmad; Zhang, Chao; Santhanagopalan, Shriram; Sahraei, Elham; Wierzbiki, Tom

2015-06-15

Propagation of failure in lithium-ion batteries during field events or under abuse is a strong function of the mechanical response of the different components in the battery. Whereas thermal and electrochemical models that capture the abuse response of batteries have been developed and matured over the years, the interaction between the mechanical behavior and the thermal response of these batteries is not very well understood. With support from the Department of Energy, NREL has made progress in coupling mechanical, thermal, and electrochemical lithium-ion models to predict the initiation and propagation of short circuits under external crush in a cell. The challenge with a cell crush simulation is to estimate the magnitude and location of the short. To address this, the model includes an explicit representation of each individual component such as the active material, current collector, separator, etc., and predicts their mechanical deformation under different crush scenarios. Initial results show reasonable agreement with experiments. In this presentation, the versatility of the approach for use with different design factors, cell formats and chemistries is explored using examples.

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Science.gov (United States)

Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

2012-05-01

The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas

Science.gov (United States)

2018-05-18

Head Trauma; Craniocerebral Injuries; Crushing Skull Injury; Head Injuries; Head Injuries, Multiple; Head Injuries, Closed; Head Trauma,Closed; Head Trauma Injury; Head Trauma, Penetrating; Head Injury, Minor; Head Injury Major; Head Injury, Open; Injuries, Craniocerebral; Injuries, Head; Multiple Head Injury; Trauma, Head

Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

Directory of Open Access Journals (Sweden)

Schlamp Cassandra L

2007-03-01

Full Text Available Abstract Background Several neurodegenerative diseases are influenced by complex genetics that affect an individual's susceptibility, disease severity, and rate of progression. One such disease is glaucoma, a chronic neurodegenerative condition of the eye that targets and stimulates apoptosis of CNS neurons called retinal ganglion cells. Since ganglion cell death is intrinsic, it is reasonable that the genes that control this process may contribute to the complex genetics that affect ganglion cell susceptibility to disease. To determine if genetic background influences susceptibility to optic nerve damage, leading to ganglion cell death, we performed optic nerve crush on 15 different inbred lines of mice and measured ganglion cell loss. Resistant and susceptible strains were used in a reciprocal breeding strategy to examine the inheritance pattern of the resistance phenotype. Because earlier studies had implicated Bax as a susceptibility allele for ganglion cell death in the chronic neurodegenerative disease glaucoma, we conducted allelic segregation analysis and mRNA quantification to assess this gene as a candidate for the cell death phenotype. Results Inbred lines showed varying levels of susceptibility to optic nerve crush. DBA/2J mice were most resistant and BALB/cByJ mice were most susceptible. F1 mice from these lines inherited the DBA/2J phenotype, while N2 backcross mice exhibited the BALB/cByJ phenotype. F2 mice exhibited an intermediate phenotype. A Wright Formula calculation suggested as few as 2 dominant loci were linked to the resistance phenotype, which was corroborated by a Punnett Square analysis of the distribution of the mean phenotype in each cross. The levels of latent Bax mRNA were the same in both lines, and Bax alleles did not segregate with phenotype in N2 and F2 mice. Conclusion Inbred mice show different levels of resistance to optic nerve crush. The resistance phenotype is heritable in a dominant fashion involving

Therapeutic effects of neurotrophic factors in experimental spinal cord injury models

Directory of Open Access Journals (Sweden)

Enomoto M

2016-03-01

Full Text Available Mitsuhiro Enomoto1,21Department of Orthopaedic and Spinal Surgery, Graduate School, 2Hyperbaric Medical Center, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Neurotrophic factors (NFs play important roles in regenerative medicine approaches to mitigate primary and secondary damage after spinal cord injury (SCI because their receptors are still present in the injured spinal cord even though the expression of the NFs themselves is decreased. Several reports have shown that NF administration increases regenerative signaling after SCI, particularly by stimulating axonal growth. However, few NFs cross the blood–brain barrier, and most of them show low stability and limited diffusion within the central nervous system. To overcome this problem, transplantation strategies using genetically modified NF-secreting Schwann cells, neural and glial progenitor cells, and mesenchymal stem cells have been applied to animal models of SCI. In particular, multifunctional NFs that bind to TrkB, TrkC, and p75NTR receptors have been discovered in the last decade and utilized in preclinical cell therapies for spinal cord repair. To achieve functional recovery after SCI, it is important to consider the different effects of each NF on axonal regeneration, and strategies should be established to specifically harness the multifunctional properties of NFs. This review provides an overview of multifunctional NFs combined with cell therapy in experimental SCI models and a proposal to implement their use as a clinically viable therapy.Keywords: spinal cord injury, neurotrophic factor, multineurotrophin, regeneration, cell transplantation

Fugitive emissions control on dry copper tailing with crushed rock armor

International Nuclear Information System (INIS)

Haase, E.F.

1992-01-01

Four inactive copper tailing impoundments totalling 1,900 acres near Ajo in southwestern Arizona were covered on horizontal surfaces with a 2 in. nominal thickness of crushed rock to control particulate emissions. The tailings are typically dominated by sand-sized particles but may also include significant PM 10 fractions towards the centers of the impoundments. The technology was selected by Phelps Dodge Corporation, after investigation of several alternatives, as a permanent and practical cover that essentially eliminates fugitive emissions. It simulates the natural desert pavement that characterizes this arid area of the Sonoran Desert. Rocky overburden was crushed to minus 3 in. diameter and broadcast on dry surfaces of tailing impoundments with all-terrain, balloon-tired spreaders. Stony residues in the rock armor tend to cement together following rainfall, forming a crust that enhances surface stability and erosion control. Slopes with windblown tailing deposition were covered to a nominal 6 in. thickness by conventional dozer pushing and blading of minus 10 in. rock over the sides. Athel trees, planted extensively since 1970 on two of the four inactive impoundments, provided partial control of fugitives, but were subjected to harsh environmental conditions, including abrasion from saltating particles. The rock armor functions as a mulch which is expected to improve water relations for existing vegetation and areas seeded with native species. New surface microenvironments, and the virtual elimination of surface creep and saltation, are expected to support native plant growth under favorable climatic conditions

Factors affecting pelvic and thoracic forces in near-side impact crashes: a study of US-NCAP, NASS, and CIREN data.

Science.gov (United States)

Tencer, Allan F; Kaufman, Robert; Mack, Christopher; Mock, Charles

2005-03-01

The goal of this study was to identify variables related to vehicle design which are associated with pelvic and thoracic accelerations as measured by the driver's (near side) crash dummy during new car assessment program (NCAP) testing of motor vehicles. Vehicle specific parameters were analyzed using NCAP side impact test results. Data from national automotive sampling system, crashworthiness data system (NASS-CDS) and crash injury research and engineering network (CIREN) (both National Highway Traffic Safety Administration (NHTSA) injury databases) were assessed to confirm NCAP test observations. In addition, door armrest stiffness measurements were performed using a mechanical tester on a sample of 40 vehicles. NCAP data showed that of 10 variables tested using multiple linear regression, vehicle weight and door crush correlated with pelvic acceleration of the driver's crash dummy (overall, r2=0.58, p=0.002, n=165). For thoracic trauma index (TTI) vehicle weight and peak door velocity correlated, significantly (overall, r2=0.41, p=0.03, n=165). Mean TTI was 63.7 g with no side airbag (n=108) and 55.6 g with a thoracic side airbag (n=54), p=0.01. The mean vehicle weight and door crush between airbag and no airbag groups were not significantly different. NASS-CDS data demonstrated a direct relationship between increased door crush and increased abbreviated injury score (AIS). CIREN data showed that occupants who sustained pelvic injuries had a median AIS of 3 with 24.9 cm of door crush, with abdominal injuries, a median AIS of 3 and 30 cm of crush, and with thoracic injuries, a median AIS of 4 and 34 cm of door crush. In addition, the frequency of bilateral pelvic injuries was significantly higher for subjects in CIREN crashes who were in a vehicle with a center console, but only if door intrusion was greater than 15 cm. This information may be useful in design of vehicles with greater protection in side impact crashes.

Experimental Investigation on Hydraulic Properties of Granular Sandstone and Mudstone Mixtures

Directory of Open Access Journals (Sweden)

Dan Ma

2018-01-01

Full Text Available The caved zone during longwall mining has high permeability, resulting in a mass of groundwater storage which causes a threat of groundwater inrush hazard to the safe mining. To investigate the hazard mechanism of granular sandstone and mudstone mixture (SMM in caved zone, this paper presents an experimental study on the effect of sandstone particle (SP and mudstone particle (MP weight ratio on the non-Darcy hydraulic properties evolution. A self-designed granular rock seepage experimental equipment has been applied to conduct the experiments. The variation of particle size distribution was induced by loading and water seepage during the test, which indicated that the particle crushing and erosion properties of mudstone were higher than those of sandstone. Porosity evolution of SMM was strongly influenced by loading (sample height and SP/MP weight ratio. The sample with higher sample height and higher weight ratio of SP achieved higher porosity value. In particular, a non-Darcy equation, for hydraulic properties (permeability κ and non-Darcy coefficient ζ calculation, was sufficient to fit the relation between the hydraulic gradient and seepage velocity. The test results indicated that, due to the absence and narrowing of fracture and void during loading, the permeability κ decreases and the non-Darcy coefficient ζ increases. The variation of the hydraulic properties of the sample within the same particle size and SP/MP weight ratio indicated that groundwater inrush hazard showed a higher probability of occurrence in sandstone strata and crushed zone (e.g., faults. Moreover, isolated fractures and voids were able to achieve the changeover from self-extension to interconnection at the last loading stage, which caused the fluctuation tendency of κ and ζ. Fluctuation ability in mudstone was higher than that in sandstone. The performance of an empirical model was also investigated for the non-Darcy hydraulic properties evolution prediction of

Nerve crush but not displacement-induced stretch of the intra-arachnoidal facial nerve promotes facial palsy after cerebellopontine angle surgery.

Science.gov (United States)

Bendella, Habib; Brackmann, Derald E; Goldbrunner, Roland; Angelov, Doychin N

2016-10-01

Little is known about the reasons for occurrence of facial nerve palsy after removal of cerebellopontine angle tumors. Since the intra-arachnoidal portion of the facial nerve is considered to be so vulnerable that even the slightest tension or pinch may result in ruptured axons, we tested whether a graded stretch or controlled crush would affect the postoperative motor performance of the facial (vibrissal) muscle in rats. Thirty Wistar rats, divided into five groups (one with intact controls and four with facial nerve lesions), were used. Under inhalation anesthesia, the occipital squama was opened, the cerebellum gently retracted to the left, and the intra-arachnoidal segment of the right facial nerve exposed. A mechanical displacement of the brainstem with 1 or 3 mm toward the midline or an electromagnet-controlled crush of the facial nerve with a tweezers at a closure velocity of 50 and 100 mm/s was applied. On the next day, whisking motor performance was determined by video-based motion analysis. Even the larger (with 3 mm) mechanical displacement of the brainstem had no harmful effect: The amplitude of the vibrissal whisks was in the normal range of 50°-60°. On the other hand, even the light nerve crush (50 mm/s) injured the facial nerve and resulted in paralyzed vibrissal muscles (amplitude of 10°-15°). We conclude that, contrary to the generally acknowledged assumptions, it is the nerve crush but not the displacement-induced stretching of the intra-arachnoidal facial trunk that promotes facial palsy after cerebellopontine angle surgery in rats.

Discrete element modeling of cemented sand and particle crushing at high pressures

OpenAIRE

de Bono, John Patrick

2013-01-01

This project aims to provide an insight into the behaviour of cemented sand under high pressures, and to further the understanding of the role of particle crushing. The discrete element method is used to investigate the micro mechanics of sand and cemented sand in high-pressure triaxial tests and one-dimensional normal compression. Using the software PFC3D, a new triaxial model has been developed, which features an effective flexible membrane that allows free deformation of the specimen ...

Comments on US approach to backfilling: Thermochemical characterization of crushed salt

International Nuclear Information System (INIS)

Smith, S.; Hume, H.

1988-01-01

From recent studies and calculations, it has become apparent that expected brine in a United States salt repository would not seriously detract from the usefulness of rock salt as backfill. It also has been shown that adding clay to the salt might add to the pressure on the emplaced waste packages. Nevertheless, the Salt Repository Project has planned to evaluate a betonite/salt mixture during the next few years. The following items have also been discussed: advantages of backfilling, variables affecting crushed salt behavior, and the general approach to a preliminary testing program

Fatal occupational injuries in the Malaysian construction sector–causes and accidental agents

Science.gov (United States)

Ayob, A.; Shaari, A. A.; Zaki, M. F. M.; Munaaim, M. A. C.

2018-04-01

The construction sector is associated with various accidents and fatal injuries. These occupational accidents are caused by numerous factors, such as lack of supervision; lack of adherence to safe work technique; failure to wear personal protective equipment; and failure to comply with the safe use of tools, vehicles, and machines. Using 2013–2016 secondary data from the Department of Occupational Safety and Health and Social Security Organization, this study conducted a descriptive exploration survey to identify common fatal occupational injuries associated with the Malaysian construction sector, as well as their causes and accidental agents. Results indicated that construction, followed by manufacturing, agriculture, forestry, logging, and fishery, are the riskiest job sectors in Malaysia. The highest incidences of occupational casualties were reported in Sarawak, Johor, and Selangor. These states accounted for approximately 13.33% to 18.18% of all cases of fatal occupational accidents. In these states, the lack of safety and health regulations and poor execution of risk management increased the risk of occupational accidents. Falls from heights accounted for 46.28% of fatal occupational injuries. Furthermore, being crushed by objects, materials, or vehicles accounted for 9.09% to 17.36% of fatal occupational injuries. Substandard work environment and transportation and lifting equipment, such as scaffolds, are primary accidental agents. Results of this study could enhance the knowledge and awareness of construction workers and management of job-related injuries to decrease the incidence of fatal occupational accidents.

Trends of Serum Electrolyte Changes in Crush syndrome patients of Bam Earthquake; a Cross sectional Study

Directory of Open Access Journals (Sweden)

Saeed Safari

2016-12-01

Full Text Available Introduction: Electrolyte imbalances are very common among crushed earthquake victims but there is notenough data regarding their trend of changes. The present study was designed to evaluate the trend of changesin sodium, calcium, and phosphorus ions among crush syndrome patients. Methods: In this retrospectivecross-sectional study, using the database of Bam earthquake victims, which was developed by Iranian Society ofNephrology following Bam earthquake, Iran, 2003, the 10-day trend of sodium, calcium, and phosphorus ionschanges in > 15 years old crush syndrome patients was evaluated. Results: 118 patients with the mean age of25.6 § 6.9 yearswere studied (57.3 male. On the first day of admission, 52.5% (95% CI: 42.7 - 62.3 of the patientshad hyponatremia, which reached 43.9% (95% CI: 28.5 - 59.3 on day 10. 100.0% of patients were hypocalcemicon admission and serum calcium level did not change dramatically during the 10 days of hospitalization. Theprevalence of hyperphosphatemia on the first day was 90.5% (95% CI: 81.5 - 99.5 and on the 10th day of hospitalization66.7% (95% CI: 48.5 - 84.8 of the patients were still affected. Conclusion: The results of the presentstudy shows the 52.5%prevalence of hyponatremia, 100% hypocalcemia, and 90.5% hyperphosphatemia amongcrush syndrome patients of Bam earthquake victims on the first day of admission. Evaluation of 10-day trendshows a slow decreasing pattern of these imbalances as after 10 days, 43.9% still remain hyponatremic, 92.3%hypocalcemic, and 66.7% hypophosphatemic.

The Animal Model of Spinal Cord Injury as an Experimental Pain Model

Directory of Open Access Journals (Sweden)

Aya Nakae

2011-01-01

Full Text Available Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of pathology. However, results can be easily misunderstood and falsely interpreted. Therefore, it is important to fully understand the symptoms of human spinal cord injury, as well as the various spinal cord injury models and the possible pathologies. The present paper summarizes results from animal models of spinal cord injury, as well as the most effective use of these models.

The Animal Model of Spinal Cord Injury as an Experimental Pain Model

Science.gov (United States)

Nakae, Aya; Nakai, Kunihiro; Yano, Kenji; Hosokawa, Ko; Shibata, Masahiko; Mashimo, Takashi

2011-01-01

Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of pathology. However, results can be easily misunderstood and falsely interpreted. Therefore, it is important to fully understand the symptoms of human spinal cord injury, as well as the various spinal cord injury models and the possible pathologies. The present paper summarizes results from animal models of spinal cord injury, as well as the most effective use of these models. PMID:21436995

Sea Dredged Gravel versus Crushed Granite as Coarse Aggregate for Self Compacting Concrete in Aggressive Environment

DEFF Research Database (Denmark)

Sørensen, Eigil V.; Kristensen, Lasse Frølich

2007-01-01

Properties of self compacting concrete (SCC) with two types of coarse aggregate - sea dredged gravel with smooth and rounded particles and crushed granite with rough and angular particles - have been studied. Sea gravel allowed a higher aggregate proportion in the concrete leading to a higher...

Concrete crushing and sampling, a methodology and technology for the unconditional release of concrete material from decommissioning

International Nuclear Information System (INIS)

Gills, R.; Lewandowski, P.; Ooms, B.; Reusen, N.; Van Laer, W.; Walthery, R.

2007-01-01

Belgoprocess started the industrial decommissioning of the main process building of the former Eurochemic reprocessing plant in 1990, after completion of a pilot project. Two small storage buildings for final products from reprocessing were dismantled to verify the assumptions made in a previous paper study on decommissioning, to demonstrate and develop dismantling techniques and to train personnel. Both buildings were emptied and decontaminated to background levels. They were demolished and the remaining concrete debris was disposed of as industrial waste and green field conditions restored. Currently, the decommissioning operations carried out at the main building have made substantial progress. They are executed on an industrial scale. In view of the final demolition of the building, foreseen to start in the middle of 2008, a clearance methodology for the concrete from the cells into the Eurochemic building has been developed. It considers at least one complete measurement of all concrete structures and the removal of all detected residual radionuclides. This monitoring sequence is followed by a controlled demolition of the concrete structures and crushing of the resulting concrete parts to smaller particles. During the crushing operations, metal parts are separated from the concrete and representative concrete samples are taken. The frequency of sampling meets the prevailing standards. In a further step, the concrete samples are milled, homogenised, and a smaller fraction is sent to the laboratory for analyses. The paper describes the developed concrete crushing and sampling methodology. (authors)

Optimization of key factors of the electrostatic separation for crushed PCB wastes using roll-type separator

International Nuclear Information System (INIS)

Wu Jiang; Li Jia; Xu Zhenming

2008-01-01

For the electrostatic separation process, the separator is most crucial. As a classical one, the roll-type corona-electrostatic separator has some advantages in recycle of waste electrical and electronic equipment (WEEE). Some researches have been done in this field and shown that there was a complex correlation between its configuration and the efficiency of the separation. In this paper, a fractional factorial design (2 v 1-5 ) was built and 32 tests were performed on a roll-type corona-electrostatic separator. The sample of granular mixture got from crushed PCB wastes (size 0.3-0.45 mm, containing 25% metal and 75% nonmetal). The experimental data were discussed and used to analyze the factors' main effect, interaction and optimization of the process. Three liner-interaction mathematical models were derived to describe the mass of middling fraction (M), conductor fraction (C) and Nonconductor fraction (NC), respectively. The results show that the efficiency of the PCB waste electrostatic separation process has a significant correlation with not only factors' main effects, but also the interaction between them

Sorption and desorption reactions of radionuclides with a crushed basalt-bentonite packing material

International Nuclear Information System (INIS)

Barney, G.S.; Lane, D.L.; Allen, C.C.; Jones, T.E.

1985-04-01

Current design of waste packages for disposal of high-level radioactive wastes in underground basalt formations includes a layer of packing material that surrounds the waste container. One of the functions of this material is to limit the release of radionuclides from a breached container into groundwater by providing a low hydraulic conductivity zone and by sorbing dissolved radionuclides. The objective of this study was to assess the radionuclide sorption capability of a proposed packing material composed of 25% sodium bentonite and 75% crushed basalt (by weight). Sorption and desorption reactions of several important waste radioelements (neptunium, uranium, plutonium, technetium, selenium, and radium) were investigated in the absence of air at 90 0 C. Uranium and neptunium were sorbed by slow reactions that follow first-order kinetics. The reaction rates are probably controlled by reduction of weakly sorbed uranium(VI) and neptunium(V) by ferrous iron in the crushed basalt component. Technetium(VII) was not reduced or sorbed under these conditions. Freundlich sorption and desorption isotherms for a given radionuclide were non-singular and show a strong tendency for sorption hysteresis. Applying the isotherm data to a one-dimensional transport model indicated that hysteretic sorption on the packing material provides an important safety factor in controlling releases of some radionuclides

Pattern and outcome of chest injuries at Bugando Medical Centre in Northwestern Tanzania

Science.gov (United States)

2011-01-01

Background Chest injuries constitute a continuing challenge to the trauma or general surgeon practicing in developing countries. This study was conducted to outline the etiological spectrum, injury patterns and short term outcome of these injuries in our setting. Patients and methods This was a prospective study involving chest injury patients admitted to Bugando Medical Centre over a six-month period from November 2009 to April 2010 inclusive. Results A total of 150 chest injury patients were studied. Males outnumbered females by a ratio of 3.8:1. Their ages ranged from 1 to 80 years (mean = 32.17 years). The majority of patients (72.7%) sustained blunt injuries. Road traffic crush was the most common cause of injuries affecting 50.7% of patients. Chest wall wounds, hemothorax and rib fractures were the most common type of injuries accounting for 30.0%, 21.3% and 20.7% respectively. Associated injuries were noted in 56.0% of patients and head/neck (33.3%) and musculoskeletal regions (26.7%) were commonly affected. The majority of patients (55.3%) were treated successfully with non-operative approach. Underwater seal drainage was performed in 39 patients (19.3%). One patient (0.7%) underwent thoracotomy due to hemopericardium. Thirty nine patients (26.0%) had complications of which wound sepsis (14.7%) and complications of long bone fractures (12.0%) were the most common complications. The mean LOS was 13.17 days and mortality rate was 3.3%. Using multivariate logistic regression analysis, associated injuries, the type of injury, trauma scores (ISS, RTS and PTS) were found to be significant predictors of the LOS (P trauma scores (ISS, RTS and PTS), the need for ICU admission and the presence of complications (P Chest injuries resulting from RTCs remain a major public health problem in this part of Tanzania. Urgent preventive measures targeting at reducing the occurrence of RTCs is necessary to reduce the incidence of chest injuries in this region. PMID:21244706

Protective effect of ebselen on experimental testicular torsion and detorsion injury.

Science.gov (United States)

Rifaioglu, M M; Motor, S; Davarci, I; Tuzcu, K; Sefil, F; Davarci, M; Nacar, A

2014-12-01

Ebselen is used as a drug in clinical trials against stroke, reperfusion injury with anti-atherosclerotic and renoprotective effects. The aim of this study is to investigate the protective effect of ebselen, on torsion/detorsion (T/D)-induced biochemical and histopathological changes in experimental testicular ischaemia/reperfusion injury. A total of 28 male Wistar Albino rats were divided into four groups: group 1(sham-operated group, n = 7), group 2(ebselen group, n = 7), group 3(torsion/detorsion + saline, n = 7) and group 4(T/D + 10 mg kg(-1) ebselen group, n = 7). The tissue homogenate samples were used for immediate nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase, catalase and glutathione measurement. Testes in all groups were evaluated for the biochemical assay and histopathological examinations. To evaluate spermatogenesis, Johnsen scoring system was used. Testicular tissue MDA and NO levels in group 3 were significantly higher than in group 1 and 4. In histological evaluation of the testicular tissues, ebselen administration improved tubular histology significantly compared with T/D group. Significant increase in histological score was observed in the testis of group 3 compared with group 1 and 2. Histological score in group 4 significantly decreased compared with group 3. Johnson score was significantly lower in T/D group compared with all other three groups, ebselen administration increased the score significantly compared with T/D group. Ebselen reduced oxidative biochemical and histopathological damage in our testicular T/D rat model. © 2013 Blackwell Verlag GmbH.

Molecular Mechanisms of Curcumin Renoprotection in Experimental Acute Renal Injury

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Youling Fan

2017-12-01

Full Text Available As a highly perfused organ, the kidney is especially sensitive to ischemia and reperfusion. Ischemia-reperfusion (IR-induced acute kidney injury (AKI has a high incidence during the perioperative period in the clinic and is an important link in ischemic acute renal failure (IARF. Therefore, IR-induced AKI has important clinical significance and it is necessary to explore to develop drugs to prevent and alleviate IR-induced AKI. Curcumin [diferuloylmethane, 1,7-bis(4-hydroxy-3-methoxiphenyl-1,6-heptadiene-3,5-dione] is a polyphenol compound derived from Curcuma longa (turmeric and was shown to have a renoprotective effect on ischemia-reperfusion injury (IRI in a previous study. However, the specific mechanisms underlying the protective role of curcumin in IR-induced AKI are not completely understood. APPL1 is a protein coding gene that has been shown to be involved in the crosstalk between the adiponectin-signaling and insulin-signaling pathways. In the study, to investigate the molecular mechanisms of curcumin effects in kidney ischemia/reperfusion model, we observed the effect of curcumin in experimental models of IR-induced AKI and we found that curcumin treatment significantly increased the expression of APPL1 and inhibited the activation of Akt after IR treatment in the kidney. Our in vitro results showed that apoptosis of renal tubular epithelial cells was exacerbated with hypoxia-reoxygenation (HR treatment compared to sham control cells. Curcumin significantly decreased the rate of apoptosis in renal tubular epithelial cells with HR treatment. Moreover, knockdown of APPL1 activated Akt and subsequently aggravated apoptosis in HR-treated renal tubular epithelial cells. Conversely, inhibition of Akt directly reversed the effects of APPL1 knockdown. In summary, our study demonstrated that curcumin mediated upregulation of APPL1 protects against ischemia reperfusion induced AKI by inhibiting Akt phosphorylation.

Numerical Investigation on Dynamic Crushing Behavior of Auxetic Honeycombs with Various Cell-Wall Angles

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Xin-chun Zhang

2015-02-01

Full Text Available Auxetic honeycombs have proven to be an attractive advantage in actual engineering applications owing to their unique mechanical characteristic and better energy absorption ability. The in-plane dynamic crushing behaviors of the honeycombs with various cell-wall angles are studied by means of explicit dynamic finite element simulation. The influences of the cell-wall angle, the impact velocity, and the edge thickness on the macro/microdeformation behaviors, the plateau stresses, and the specific energy absorption of auxetic honeycombs are discussed in detail. Numerical results show, that except for the impact velocity and the edge thickness, the in-plane dynamic performances of auxetic honeycombs also rely on the cell-wall angle. The “> <”-mode local deformation bands form under low- or moderate-velocity impacting, which results in lateral compression shrinkage and shows negative Poisson's ratio during the crushing. For the given impact velocity, the plateau stress at the proximal end and the energy-absorbed ability can be improved by increasing the negative cell angle, the relative density, the impact velocity, and the matrix material strength. When the microcell parameters are the constant, the plateau stresses are proportional to the square of impact velocity.

A big step change : new mobile slurry preparation and crushing technology on the horizon

Energy Technology Data Exchange (ETDEWEB)

Budd, G.

2007-09-15

The efficiency and productivity of the trucks used in oil sands mining operations can be compromised by unstable terrain, and they consume large amount of fuel. Hydro-transport systems with slurry preparation facilities may soon eliminate the expenses associated with truck and shovel processes. The slurry preparation facilities use on-board reject handling systems to remove large pieces of ore that can't be used in crushers. However, they are hard to move. Researchers are now focusing on the development of a semi-mobile slurry preparation facility that uses mobile crushing and sizing equipment. The equipment uses large tractor tracks instead of wheels and tires, and can accomplish the same amount of work as 6 trucks. Using the system, mine scoop shovels dump ore into a hopper on the mobile unit. The ore is then conveyed to the mobile unit's onboard primary crusher or sizer. Staged crushing is combined with water addition and mixing at the mine site to prepare an oil and slurry ready for hydro-transport. It was concluded that the system may significantly reduce the use of shovel and truck operations in the oil sands industry. 2 figs.

The effect of cargo on the crush loading of RAM transportation packages in ship collisions

International Nuclear Information System (INIS)

Radloff, H.D.; Ammerman, D.J.

1998-03-01

Recent intercontinental radioactive material shipping campaigns have focused public and regulatory attention on the safety of transport of this material by ocean-going vessels. One major concern is the response of the vessel and onboard radioactive material (RAM) packages during a severe ship-to-ship collision. These collisions occur at velocities less than the velocity obtained in the Type B package regulatory impact event and the bow of the striking ship is less rigid than the unyielding target used in those tests (Ammerman and Daidola, 1996). This implies that ship impact is not a credible scenario for damaging the radioactive material packages during ship collisions. It is possible, however, for these collisions to generate significant amounts of crush force by the bow of the impacting ship overrunning the package. It is the aim of this paper to determine an upper bound on the magnitude of this crush force taking into account the strength of the radioactive material carrying vessel and any other cargo that may be stowed in the same hold as the radioactive material

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion.

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Franck, Grégory; Mawson, Thomas L; Folco, Eduardo J; Molinaro, Roberto; Ruvkun, Victoria; Engelbertsen, Daniel; Liu, Xin; Tesmenitsky, Yevgenia; Shvartz, Eugenia; Sukhova, Galina K; Michel, Jean-Baptiste; Nicoletti, Antonino; Lichtman, Andrew; Wagner, Denisa; Croce, Kevin J; Libby, Peter

2018-06-22

Neutrophils likely contribute to the thrombotic complications of human atheromata. In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify and propagate arterial intimal injury and thrombosis. PAD4 (peptidyl arginine deiminase 4) participates in NET formation, but an understanding of this enzyme's role in atherothrombosis remains scant. This study tested the hypothesis that PAD4 and NETs influence experimental atherogenesis and in processes implicated in superficial erosion, a form of plaque complication we previously associated with NETs. Bone marrow chimeric Ldlr deficient mice reconstituted with either wild-type or PAD4-deficient cells underwent studies that assessed atheroma formation or procedures designed to probe mechanisms related to superficial erosion. PAD4 deficiency neither retarded fatty streak formation nor reduced plaque size or inflammation in bone marrow chimeric mice that consumed an atherogenic diet. In contrast, either a PAD4 deficiency in bone marrow-derived cells or administration of DNaseI to disrupt NETs decreased the extent of arterial intimal injury in mice with arterial lesions tailored to recapitulate characteristics of human atheroma complicated by erosion. These results indicate that PAD4 from bone marrow-derived cells and NETs do not influence chronic experimental atherogenesis, but participate causally in acute thrombotic complications of intimal lesions that recapitulate features of superficial erosion. © 2018 American Heart Association, Inc.

Investigations into the residual strength of a 2.5 m wide Bushveld Merensky Reef crush pillar

CSIR Research Space (South Africa)

Watson, BP

2008-08-01

Full Text Available of falls of ground in already dangerous areas, and the larger pillars decrease the extraction ratio. This paper describes the evaluation of stress measurements conducted in two boreholes over a crush pillar with dimensions 2.5 m x 4.0 m, and a height of 1...

Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury.

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Bucan, Vesna; Vaslaitis, Desiree; Peck, Claas-Tido; Strauß, Sarah; Vogt, Peter M; Radtke, Christine

2018-06-21

Peripheral nerve injury requires optimal conditions in both macro-environment and microenvironment for promotion of axonal regeneration. However, most repair strategies of traumatic peripheral nerve injury often lead to dissatisfying results in clinical outcome. Though various strategies have been carried out to improve the macro-environment, the underlying molecular mechanism of axon regeneration in the microenvironment provided by nerve conduit remains unclear. In this study, we evaluate the effects of from adipose-derived mesenchymal stem cells (adMSCs) originating exosomes with respect to sciatic nerve regeneration and neurite growth. Molecular and immunohistochemical techniques were used to investigate the presence of characteristic exosome markers. A co-culture system was established to determine the effect of exosomes on neurite elongation in vitro. The in vivo walking behaviour of rats was evaluated by footprint analysis, and the nerve regeneration was assessed by immunocytochemistry. adMSCs secrete nano-vesicles known as exosomes, which increase neurite outgrowth in vitro and enhance regeneration after sciatic nerve injury in vivo. Furthermore, we showed the presence of neural growth factors transcripts in adMSC exosomes for the first time. Our results demonstrate that exosomes, constitutively produced by adMSCs, are involved in peripheral nerve regeneration and have the potential to be utilised as a therapeutic tool for effective tissue-engineered nerves.

Protective Effect Of Bosentan In Experimental Cerebral Ischemia-Reperfusion Injury

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Eser Ataş

2013-02-01

Full Text Available OBJECTIVE: In cerebral ischemia, there are many factors that start the events leading to cell death. These factors contain free radical production, excitotoxicity, sodium and calcium flow disruption, enzymatic changes, stimulation of the inflamatuar process, the activation of platelets and leukocytes, delayed coagulation, endothelial dysfunction and endothelin (ET release. Bosentan is the competitive antagonist of endothelin receptors; ETA and ETB. The aim of this study is to determine whether the protective effects of bosentan in experimental cerebral ischemia reperfusion injury. MATERIAL and METHODS: In this study, after ischemia-reperfusion procedure, bosentan molecule was regularly given to rats for 5 days. The brain tissues of decapitated rats were histopathologically examined. The levels of oxidant and antioxidant were determined in these brain tissues. RESULTS: It was observed that antioxidant levels and histopathological examinations were in rats given bosentan better than control group rats. CONCLUSION: In conclusion, this study has showed that bosentan may be an agent which could reduce negative effects resulting from neuronal death associated with ischemic stroke.

Cardioprotection against experimental myocardial ischemic injury using cornin

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Y. Xu

2016-01-01

Full Text Available Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and reperfusion (I/R injury in vivo, and elucidated its potential mechanism in vitro. Effects of cornin on cell viability, as well as expression of phospho-CREB and phospho-Akt in hypoxic H9c2 cells in vitro, and myocardial I/R injury in vivo, were investigated. Cornin attenuated hypoxia-induced cytotoxicity significantly in H9c2 cells in a concentration-dependent manner. Treatment of H9c2 cells with cornin (10 µM blocked the reduction of expression of phospho-CREB and phospho-Akt in a hypoxic condition. Treatment of rats with cornin (30 mg/kg, iv protected them from myocardial I/R injury as indicated by a decrease in infarct volume, improvement in hemodynamics, and reduction of severity of myocardial damage. Cornin treatment also attenuated the reduction of expression of phospho-CREB and phospho-Akt in ischemic myocardial tissue. These data suggest that cornin exerts protective effects due to an increase in expression of phospho-CREB and phospho-Akt.

Medical Efforts and Injury Patterns of Military Hospital Patients Following the 2013 Lushan Earthquake in China: A Retrospective Study

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Peng Kang

2015-08-01

Full Text Available The aim of this paper is to investigate medical efforts and injury profiles of victims of the Lushan earthquake admitted to three military hospitals. This study retrospectively investigated the clinical records of 266 admitted patients evacuated from the Lushan earthquake area. The 2005 version of the Abbreviated Injury Scale (AIS-2005 was used to identify the severity of each injury. Patient demographic data, complaints, diagnoses, injury types, prognosis, means of transportation, and cause of injury were all reviewed individually. The statistical analysis of the study was conducted primarily using descriptive statistics. Of the 266 patients, 213 (80.1% were admitted in the first two days. A total of 521 injury diagnoses were recorded in 266 patients. Earthquake-related injuries were primarily caused by buildings collapsing (38.4% and victims being struck by objects (33.8%; the most frequently injured anatomic sites were the lower extremities and pelvis (34.2% and surface area of the body (17.9%. Fracture (41.5% was the most frequent injury, followed by soft tissue injury (27.5%, but crush syndrome was relatively low (1.2% due to the special housing structures in the Lushan area. The most commonly used procedure was suture and dressings (33.7%, followed by open reduction and internal fixation (21.9%.The results of this study help formulate recommendations to improve future disaster relief and emergency planning in remote, isolated, and rural regions of developing countries.

Medical Efforts and Injury Patterns of Military Hospital Patients Following the 2013 Lushan Earthquake in China: A Retrospective Study.

Science.gov (United States)

Kang, Peng; Tang, Bihan; Liu, Yuan; Liu, Xu; Liu, Zhipeng; Lv, Yipeng; Zhang, Lulu

2015-08-31

The aim of this paper is to investigate medical efforts and injury profiles of victims of the Lushan earthquake admitted to three military hospitals. This study retrospectively investigated the clinical records of 266 admitted patients evacuated from the Lushan earthquake area. The 2005 version of the Abbreviated Injury Scale (AIS-2005) was used to identify the severity of each injury. Patient demographic data, complaints, diagnoses, injury types, prognosis, means of transportation, and cause of injury were all reviewed individually. The statistical analysis of the study was conducted primarily using descriptive statistics. Of the 266 patients, 213 (80.1%) were admitted in the first two days. A total of 521 injury diagnoses were recorded in 266 patients. Earthquake-related injuries were primarily caused by buildings collapsing (38.4%) and victims being struck by objects (33.8%); the most frequently injured anatomic sites were the lower extremities and pelvis (34.2%) and surface area of the body (17.9%). Fracture (41.5%) was the most frequent injury, followed by soft tissue injury (27.5%), but crush syndrome was relatively low (1.2%) due to the special housing structures in the Lushan area. The most commonly used procedure was suture and dressings (33.7%), followed by open reduction and internal fixation (21.9%).The results of this study help formulate recommendations to improve future disaster relief and emergency planning in remote, isolated, and rural regions of developing countries.

Evoked electromyography to rocuronium in orbicularis oris and gastrocnemius in facial nerve injury in rabbits.

Science.gov (United States)

Xing, Yian; Chen, Lianhua; Li, Shitong

2013-11-01

Muscles innervated by the facial nerve show different sensitivities to muscle relaxants than muscles innervated by somatic nerves, especially in the presence of facial nerve injury. We compared the evoked electromyography (EEMG) response of orbicularis oris and gastrocnemius in with and without a non-depolarizing muscle relaxant in a rabbit model of graded facial nerve injury. Differences in EEMG response and inhibition by rocuronium were measured in the orbicularis oris and gastrocnemius muscles 7 to 42 d after different levels of facial nerve crush injuries in adult rabbits. Baseline EEMG of orbicularis oris was significantly smaller than those of the gastrocnemius. Gastrocnemius was more sensitive to rocuronium than the facial muscles (P rocuronium was negatively correlated with the magnitude of facial nerve injury but the sensitivity to rocuronium was not. No significant difference was found in the onset time and the recovery time of rocuronium among gastrocnemius and normal or damaged facial muscles. Muscles innervated by somatic nerves are more sensitive to rocuronium than those innervated by the facial nerve, but while facial nerve injury reduced EEMG responses, the sensitivity to rocuronium is not altered. Partial neuromuscular blockade may be a suitable technique for conducting anesthesia and surgery safely when EEMG monitoring is needed to preserve and protect the facial nerve. Additional caution should be used if there is a risk of preexisting facial nerve injury. Copyright © 2013 Elsevier Inc. All rights reserved.

Injury Profiles Associated with Artisanal and Small-Scale Gold Mining in Tarkwa, Ghana.

Science.gov (United States)

Calys-Tagoe, Benedict N L; Ovadje, Lauretta; Clarke, Edith; Basu, Niladri; Robins, Thomas

2015-07-10

Artisanal and small-scale gold mining (ASGM) is inherently risky, but little is known about mining-associated hazards and injuries despite the tremendous growth worldwide of ASGM and the benefits it offers. The current study aimed to characterize the physical injuries associated with ASGM in Ghana to guide policy formulation. A cross-sectional survey was carried out in the Tarkwa mining district of the Western Region of Ghana in 2014. A total of 404 small-scale miners were recruited and interviewed regarding their occupational injury experiences over the preceding 10 years using a paper-based structured questionnaire. Nearly one-quarter (23.5%) of the miners interviewed reported getting injured over the previous 10 years, and the overall injury rate was calculated to be 5.39 per 100 person years. The rate was significantly higher for women (11.93 per 100 person years) and those with little mining experience (e.g., 25.31 per 100 person years for those with less than one year of work experience). The most injury-prone mining activities were excavation (58.7%) and crushing (23.1%), and over 70% of the injuries were reported to be due to miners being hit by an object. The majority of the injuries (57%) were lacerations, and nearly 70% of the injuries were to the upper or lower limbs. Approximately one-third (34.7%) of the injuries resulted in miners missing more than two weeks of work. One-quarter of the injured workers believed that abnormal work pressure played a role in their injuries, and nearly two-fifths believed that their injuries could have been prevented, with many citing personal protective equipment as a solution. About one-quarter of the employees reported that their employers never seemed to be interested in the welfare or safety of their employees. These findings greatly advance our understanding of occupational hazards and injuries amongst ASGM workers and help identify several intervention points.

Glibenclamide reduces secondary brain damage after experimental traumatic brain injury.

Science.gov (United States)

Zweckberger, K; Hackenberg, K; Jung, C S; Hertle, D N; Kiening, K L; Unterberg, A W; Sakowitz, O W

2014-07-11

Following traumatic brain injury (TBI) SUR1-regulated NCCa-ATP (SUR1/TRPM4) channels are transcriptionally up-regulated in ischemic astrocytes, neurons, and capillaries. ATP depletion results in depolarization and opening of the channel leading to cytotoxic edema. Glibenclamide is an inhibitor of SUR-1 and, thus, might prevent cytotoxic edema and secondary brain damage following TBI. Anesthetized adult Sprague-Dawley rats underwent parietal craniotomy and were subjected to controlled cortical impact injury (CCI). Glibenclamide was administered as a bolus injection 15min after CCI injury and continuously via osmotic pumps throughout 7days. In an acute trial (180min) mean arterial blood pressure, heart rate, intracranial pressure, encephalographic activity, and cerebral metabolism were monitored. Brain water content was assessed gravimetrically 24h after CCI injury and contusion volumes were measured by MRI scanning technique at 8h, 24h, 72h, and 7d post injury. Throughout the entire time of observation neurological function was quantified using the "beam-walking" test. Glibenclamide-treated animals showed a significant reduction in the development of brain tissue water content(80.47%±0.37% (glibenclamide) vs. 80.83%±0.44% (control); pbeam-walking test throughout 7days. In accordance to these results and the available literature, glibenclamide seems to have promising potency in the treatment of TBI. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

Coagulation defects in experimental hepatic injury in the dog.

Science.gov (United States)

Osbaldiston, G W; Hoffman, M W

1971-04-01

Alteration in activity of blood coagulation factors in dogs with acute hepatic injury caused by oral carbon tetrachloride dosing was studied. Coagulation Factors II, VII and IX were dramatically reduced within 48 hours but recovered to normal in the next five days. Because surgery is rarely performed on dogs with hepatic necrosis, the use of fresh whole blood tranfusion to improve the coagulation defect in hepatic injury was also studied. Transfusion was found to have only a temporary beneficial effect.

Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report

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Ichim Thomas E

2010-11-01

Full Text Available Abstract Cellular therapy for spinal cord injury (SCI is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood ex-vivo expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI.

Experimental assessment of the role of the blood flow inhibition in hyperglycemia-enhanced radiation injury to tumor

International Nuclear Information System (INIS)

Kozin, S.V.; Sevast'yanov, A.I.; Yarmonenko, S.P.

1986-01-01

Experimental assessment of the role of the blood flow inhibition in enhancement of radiation injury to tumors using short-term hyperglycemia was provided. Experiments on mice with Ehrlich solid carcinoma showed the dependence of a rise of the antitumor effect of preceding radiation induced by glucose and glucose combined with mexamin on a degree of the blood flow inhibition under the influence of these modifying agents. It was established that a considerable enhancement of radiation injury occured but in such tumors where short-term hyperglycemia and mexamin decreased the blood flow level not less than 5-10 fold as estimated by 133 Xe clearance. The results of the above experiments showed that the noticeable inhibition of the blood flow in tumors was a necessary tough, probably, not the only condition for a high efficacy of short-term hyperglycemia used an ajuvant to radiotherapy

Low-frequency pulsed electromagnetic field pretreated bone marrow-derived mesenchymal stem cells promote the regeneration of crush-injured rat mental nerve.

Science.gov (United States)

Seo, NaRi; Lee, Sung-Ho; Ju, Kyung Won; Woo, JaeMan; Kim, BongJu; Kim, SoungMin; Jahng, Jeong Won; Lee, Jong-Ho

2018-01-01

Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field (PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments. In in vitro experiments, quantitative DNA analysis was performed to determine the proliferation of BMSCs, and reverse transcription-polymerase chain reaction was performed to detect S100 (Schwann cell marker), glial fibrillary acidic protein (astrocyte marker), and brain-derived neurotrophic factor and nerve growth factor (neurotrophic factors) mRNA expression. In the in vivo experiments, rat models of crush-injured mental nerve established using clamp method were randomly injected with low-frequency PEMF pretreated BMSCs, unpretreated BMSCs or PBS at the injury site (1 × 10 6 cells). DiI-labeled BMSCs injected at the injury site were counted under the fluorescence microscope to determine cell survival. One or two weeks after cell injection, functional recovery of the injured nerve was assessed using the sensory test with von Frey filaments. Two weeks after cell injection, axonal regeneration was evaluated using histomorphometric analysis and retrograde labeling of trigeminal ganglion neurons. In vitro experiment results revealed that low-frequency PEMF pretreated BMSCs proliferated faster and had greater mRNA expression of growth factors than unpretreated BMSCs. In vivo experiment results revealed that compared with injection of unpretreated BMSCs, injection of low-frequency PEMF pretreated BMSCs led to higher myelinated axon count and axon density and

Differential Expression of Sox11 and Bdnf mRNA Isoforms in the Injured and Regenerating Nervous Systems

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Felix L. Struebing

2017-11-01

Full Text Available In both the central nervous system (CNS and the peripheral nervous system (PNS, axonal injury induces changes in neuronal gene expression. In the PNS, a relatively well-characterized alteration in transcriptional activation is known to promote axonal regeneration. This transcriptional cascade includes the neurotrophin Bdnf and the transcription factor Sox11. Although both molecules act to facilitate successful axon regeneration in the PNS, this process does not occur in the CNS. The present study examines the differential expression of Sox11 and Bdnf mRNA isoforms in the PNS and CNS using three experimental paradigms at different time points: (i the acutely injured CNS (retina after optic nerve crush and PNS (dorsal root ganglion after sciatic nerve crush, (ii a CNS regeneration model (retina after optic nerve crush and induced regeneration; and (iii the retina during a chronic form of central neurodegeneration (the DBA/2J glaucoma model. We find an initial increase of Sox11 in both PNS and CNS after injury; however, the expression of Bdnf isoforms is higher in the PNS relative to the CNS. Sustained upregulation of Sox11 is seen in the injured retina following regeneration treatment, while the expression of two Bdnf mRNA isoforms is suppressed. Furthermore, two isoforms of Sox11 with different 3′UTR lengths are present in the retina, and the long isoform is specifically upregulated in later stages of glaucoma. These results provide insight into the molecular cascades active during axonal injury and regeneration in mammalian neurons.

Experimental spinal cord trauma: a review of mechanically induced spinal cord injury in rat models.

Science.gov (United States)

Abdullahi, Dauda; Annuar, Azlina Ahmad; Mohamad, Masro; Aziz, Izzuddin; Sanusi, Junedah

2017-01-01

It has been shown that animal spinal cord compression (using methods such as clips, balloons, spinal cord strapping, or calibrated forceps) mimics the persistent spinal canal occlusion that is common in human spinal cord injury (SCI). These methods can be used to investigate the effects of compression or to know the optimal timing of decompression (as duration of compression can affect the outcome of pathology) in acute SCI. Compression models involve prolonged cord compression and are distinct from contusion models, which apply only transient force to inflict an acute injury to the spinal cord. While the use of forceps to compress the spinal cord is a common choice due to it being inexpensive, it has not been critically assessed against the other methods to determine whether it is the best method to use. To date, there is no available review specifically focused on the current compression methods of inducing SCI in rats; thus, we performed a systematic and comprehensive publication search to identify studies on experimental spinalization in rat models, and this review discusses the advantages and limitations of each method.

The Animal Model of Spinal Cord Injury as an Experimental Pain Model

OpenAIRE

Nakae, Aya; Nakai, Kunihiro; Yano, Kenji; Hosokawa, Ko; Shibata, Masahiko; Mashimo, Takashi

2011-01-01

Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of patholo...

Concrete crushing and sampling, a methodology and technology for the unconditional release of concrete material from decommissioning

International Nuclear Information System (INIS)

Baumann, S.; Teunckens, L.; Walthery, R.; Lewandowski, P.; Millen, D.

2002-01-01

Belgoprocess started the industrial decommissioning of the main process building of the former Eurochemic reprocessing plant in 1990, after completion of a pilot project. Two small storage buildings for final products from reprocessing were dismantled to verify the assumptions made in a previous paper study on decommissioning, to demonstrate and develop dismantling techniques and to train personnel. Both buildings were emptied and decontaminated to background levels. They were demolished and the remaining concrete debris was disposed of as industrial waste and green field conditions restored. Currently, the decommissioning operations carried out at the main building have made substantial progress. They are executed on an industrial scale and will continue till the end of 2005. In view of the final demolition of the building, a clearance methodology has to be proposed. Application of the methodology applied for the storage buildings of the pilot project is complicated for several reasons. Although this methodology is not rejected as such, an alternative has been studied thoroughly. It considers at least one complete measurement of all concrete structures and the removal of all detected residual radioactivity. This monitoring sequence is followed by a controlled demolition of the concrete structures and crushing of the resulting concrete parts to smaller particles. During the crushing operations, metal parts are separated from the concrete and representative concrete samples are taken. The frequency of sampling meets the prevailing standards. In a further step, the concrete samples are milled, homogenised, and a smaller fraction is sent to the laboratory for analyses. The paper describes the developed concrete crushing and sampling methodology. (authors)

"DK Crush" Technique for a Tightly Stenosed Conjoined SVG Lesion in a Patient with Acute Coronary Syndrome and Cardiogenic Shock.

Science.gov (United States)

Chen, Kuan-Ju; Lee, Wen-Lieng; Liu, Tsun-Jui; Chang, Wei-Chun; Wang, Kuo-Yang; Su, Chieh-Shou

2015-05-01

Coronary artery bifurcation disease of saphenous venous graft (SVG) is extremely rare. SVG disease remains a challenging lesion to treat because of increased morbidity and mortality with repeated coronary artery bypass graft surgery (CABG), high rates of periprocedural complications, and in-stent restenosis or occlusion requiring repeat revascularization with percutaneous coronary intervention. Herein, we present the first reported case of using the "DK crush" technique to treat an inverted Y-shaped SVG bifurcation disease in a patient with a prior CABG and new-onset acute coronary syndrome. Arising from our treatment, favorable immediate and mid-term angiographic and clinical outcomes were obtained. Coronary artery bypass surgery (CABG); "DK crush" technique; Saphenous venous graft (SVG).

Schwann cell-derived Apolipoprotein D controls the dynamics of post-injury myelin recognition and degradation

Directory of Open Access Journals (Sweden)

Nadia eGarcía-Mateo

2014-11-01

Full Text Available Management of lipids, particularly signaling lipids that control neuroinflammation, is crucial for the regeneration capability of a damaged nervous system. Knowledge of pro- and anti-inflammatory signals after nervous system injury is extensive, most of them being proteins acting through well-known receptors and intracellular cascades. However, the role of lipid binding extracellular proteins able to modify the fate of lipids released after injury is not well understood.Apolipoprotein D (ApoD is an extracellular lipid binding protein of the Lipocalin family induced upon nervous system injury. Our previous study shows that axon regeneration is delayed without ApoD, and suggests its participation in early events during Wallerian degeneration. Here we demonstrate that ApoD is expressed by myelinating and non-myelinating Schwann cells and is induced early upon nerve injury. We show that ApoD, known to bind arachidonic acid (AA, also interacts with lysophosphatidylcholine (LPC in vitro. We use an in vivo model of nerve crush injury, a nerve explant injury model, and cultured macrophages exposed to purified myelin, to uncover that: (i ApoD regulates denervated Schwann cell-macrophage signaling, dampening MCP1- and Tnf-dependent macrophage recruitment and activation upon injury; (ii ApoD controls the over-expression of the phagocytosis activator Galectin-3 by infiltrated macrophages; (iii ApoD controls the basal and injury-triggered levels of LPC and AA; (iv ApoD modifies the dynamics of myelin-macrophage interaction, favoring the initiation of phagocytosis and promoting myelin degradation.Regulation of macrophage behaviour by Schwann-derived ApoD is therefore a key mechanism conditioning nerve injury resolution. These results place ApoD as a lipid binding protein controlling the signals exchanged between glia, neurons and blood-borne cells during nerve recovery after injury, and open the possibility for a therapeutic use of ApoD as a regeneration

[Comparative analysis of the clinical characteristics of orthopedic inpatients in Lushan and Wenchuan earthquakes].

Science.gov (United States)

Shi, Xiao-Jun; Wang, Guang-Lin; Pei, Fu-Xing; Song, Yue-Ming; Yang, Tian-Fu; Tu, Chong-Qi; Huang, Fu-Guo; Liu, Hao; Lin, Wei

2013-10-18

To systematically analyze and compare the clinical characteristics of orthopedic inpatients in Lushan and Wenchuan earthquake, so as to provide useful references for future earthquakes injury rescue. Based on the orthopedic inpatients in Lushan and Wenchuan earthquakes, the data of the age, gender, injury causes, body injured parts and speed of transport were classified and compared. The duration of patients admitted to hospital lasted long and the peak appeared late in Wenchuan earthquake, which is totally opposed to Lushan earthquake. There was no significant difference in the patient's age and gender between the two earthquakes. However, the occurrence rate of crush syndrome, amputation, gas gangrene, vascular injury and multiple organ dysfunction syndrome (MODS) in Wenchuan earthquake was much higher than that in Lushan earthquake. Blunt traumas or crush-related injuries (79.6%) are the major injury cause in Wenchuan earthquake, however, high falling injuries and falls (56.8%) are much higher than blunt trauma or crush-related injuries (39.2%) in Lushan earthquake. The incidence rate of foot fractures, spine fractures and multiple fractures in Lushan earthquake was higher than that in Wenchuan earthquake, but that of open fractures and lower limb fractures was lower than that in Wenchuan earthquake. The rapid rescue scene is the cornerstone of successful treatment, early rescue and transport obviously reduce the incidence of the wound infection, crush syndrome, MODS and amputation. Popularization of correct knowledge of emergency shelters will help to reduce the damage caused by blindly jumping or escaping while earthquake happens.

Review of Van earthquakes form an orthopaedic perspective: a multicentre retrospective study.

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Guner, Savas; Guner, Sukriye Ilkay; Isik, Yasemin; Gormeli, Gokay; Kalender, Ali Murat; Turktas, Ugur; Gokalp, Mehmet Ata; Gozen, Abdurrahim; Isik, Mustafa; Ozkan, Sezai; Turkozu, Tulin; Karadas, Sevdegul; Ceylan, Mehmet Fethi; Ediz, Levent; Bulut, Mehmet; Gunes, Yusuf; Gormeli, Ayse; Erturk, Cemil; Eseoglu, Metehan; Dursun, Recep

2013-01-01

This is a descriptive analysis, of victims of Turkey's October 23, 2011 and November 21, 2011 Van earthquakes. The goal of this study is investigated the injury profile of the both earthquakes in relation to musculoskeletal trauma. We retrospectively reviewed medical records of 3,965 patients admitted to in seven hospitals. A large share of these injuries were soft tissue injuries, followed by fractures, crush injuries, crush syndromes, nerve injuries, vascular injuries, compartment syndrome and joint dislocations. A total of 73 crush injuries were diagnosed and 31 of them were developed compartment syndrome. The patients with closed undisplaced fractures were treated with casting braces. For closed unstable fractures with good skin and soft-tissue conditions, open reduction and internal fixation was performed. All patients with open fracture had an external fixator applied after adequate debridement. Thirty one of 40 patients with compartment syndrome were treated by fasciotomy. For twelve of them, amputation was necessary. The most common procedure performed was debridement, followed by open reduction and internal fixation and closed reduction-casting, respectively. The results of this study may provide the basis for future development of strategy to optimise attempts at rescue and plan treatment of survivors with musculoskeletal injuries after earthquakes.

A preconditioning nerve lesion inhibits mechanical pain hypersensitivity following subsequent neuropathic injury

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Wu Ann

2011-01-01

Full Text Available Abstract Background A preconditioning stimulus can trigger a neuroprotective phenotype in the nervous system - a preconditioning nerve lesion causes a significant increase in axonal regeneration, and cerebral preconditioning protects against subsequent ischemia. We hypothesized that a preconditioning nerve lesion induces gene/protein modifications, neuronal changes, and immune activation that may affect pain sensation following subsequent nerve injury. We examined whether a preconditioning lesion affects neuropathic pain and neuroinflammation after peripheral nerve injury. Results We found that a preconditioning crush injury to a terminal branch of the sciatic nerve seven days before partial ligation of the sciatic nerve (PSNL; a model of neuropathic pain induced a significant attenuation of pain hypersensitivity, particularly mechanical allodynia. A preconditioning lesion of the tibial nerve induced a long-term significant increase in paw-withdrawal threshold to mechanical stimuli and paw-withdrawal latency to thermal stimuli, after PSNL. A preconditioning lesion of the common peroneal induced a smaller but significant short-term increase in paw-withdrawal threshold to mechanical stimuli, after PSNL. There was no difference between preconditioned and unconditioned animals in neuronal damage and macrophage and T-cell infiltration into the dorsal root ganglia (DRGs or in astrocyte and microglia activation in the spinal dorsal and ventral horns. Conclusions These results suggest that prior exposure to a mild nerve lesion protects against adverse effects of subsequent neuropathic injury, and that this conditioning-induced inhibition of pain hypersensitivity is not dependent on neuroinflammation in DRGs and spinal cord. Identifying the underlying mechanisms may have important implications for the understanding of neuropathic pain due to nerve injury.

Evaluation of leachate emissions from crushed rock and municipal solid waste incineration bottom ash used in road construction.

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Lidelöw, S; Lagerkvist, A

2007-01-01

Three years of leachate emissions from municipal solid waste incineration bottom ash and crushed rock in a full-scale test road were evaluated. The impact of time, construction design, and climate on the emissions was studied, and the predicted release from standard leaching tests was compared with the measured release from the road. The main pollutants and their respective concentrations in leachate from the roadside slope were Al (12.8-85.3 mg l(-1)), Cr (2-125 microg l(-1)), and Cu (0.15-1.9 mg l(-1)) in ash leachate and Zn (1-780 microg l(-1)) in crushed rock leachate. From the ash, the initial Cl(-) release was high ( approximately 20 g l(-1)). After three years, the amount of Cu and Cl(-) was in the same range in both leachates, while that of Al and Cr still was more than one order of magnitude higher in ash leachate. Generally, the release was faster from material in the uncovered slopes than below the pavement. Whether the road was asphalted or not, however, had minor impacts on the leachate quality. During rain events, diluted leachates with respect to, e.g., salts were observed. The leaching tests failed to simulate field leaching from the crushed rock, whereas better agreement was observed for the ash. Comparisons of constituent release from bottom ash and conventional materials solely based on such tests should be avoided.

EFFECT OF USE OF BONE-MARROW CENTRIFUGATE ON MUSCLE INJURY TREATMENT: EXPERIMENTAL STUDY ON RABBITS

Science.gov (United States)

Vieira, Daniel Ferreira Fernandes; Guarniero, Roberto; Vaz, Carlos Eduardo Sanches; de Santana, Paulo José

2015-01-01

Objective: The objective of this study was to evaluate the effect of bone-marrow centrifugate on the healing of muscle injuries in rabbits. Methods: This experimental study involved use of fifteen adult male New Zealand White rabbits. Each animal received a transverse lesion in the middle of the right tibialis anterior muscle, to which an absorbable collagen sponge, soaked in a centrifugate of bone marrow aspirate from the ipsilateral iliac bone, was added. The left hind limb was used as a control and underwent the same injury, but in this case only the absorbable collagen sponge. Thirty days later, the animals were sacrificed to study the muscle healing. These muscle areas were subjected to histological analysis with histomorphometry, with the aim of measuring the number of muscle cells per square micrometer undergoing regeneration and the proportion of resultant fibrosis. Results: The centrifugation method used in this study resulted in an average concentration of nucleated cells greater than the number of these cells in original aspirates, without causing significant cell destruction. Addition of the bone marrow centrifugate did not result in any significant increase in the number of muscle cells undergoing regeneration, in relation to the control group. There was also no significant difference in the proportion of resultant fibrosis, compared with the control group. Conclusion: Administration of the bone marrow centrifugate used in this study did not favor healing of muscle injuries in rabbits. PMID:27047832

Behavior of crushed salt under heat source in boreholes in a salt mine (Amelie Mine, Alsace Potash Mines, France)

International Nuclear Information System (INIS)

Ghoreychi, M.

1991-01-01

The study of thermomechanical interaction between rock salt and crushed salt, used as a backfilling material at the final stage of radioactive waste disposal in salt formations, led to perform an in situ test at the Amelie Mine(The Alsace Potash Mines in France). The field tests site is located at a depth of 520m and the tests were performed in six parallel boreholes. Five boreholes were backfilled using three types of crushed salt, changing by their grain size (fine = 0.4 mm; natural = 1 mm; coarse = 2 mm). The sixth borehole was not backfilled in order to witness for rock salt behavior without backfilling confinement. Except the first borehole used as a pilot test, the four backfilled boreholes were heated during four months with two levels of heat output (1.6 kW, then 2.2 kW). Cooling was also followed during four months after heating interruption. The maximum of temperature obtained on the wall of the backfilled boreholes was about 100 0 C during the first field test and 130 0 C during the second. The thermal diffusivity of rock mass and the coefficient of heat exchange by convection are studied. In spite of the case that the crushed salt thermal conductivity is initially ten times less than of rock salt, no excessive temperature concentration was obtained on the heat sources

Leaching behaviour of copper slag, construction and demolition waste and crushed rock used in a full-scale road construction.

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Lidelöw, Sofia; Mácsik, Josef; Carabante, Ivan; Kumpiene, Jurate

2017-12-15

The leaching behaviour of a road construction with fayalitic copper slag, recycled concrete and crushed rock as sub-base materials was monitored over ten years. All studied materials used in the road construction, including crushed rock, contained concentrations of several elements exceeding the guideline values recommended by the Swedish EPA for total element concentrations for waste materials used in constructions. Despite that, leaching from the road construction under field conditions in general was relatively low. The leachates from the recycled materials contained higher concentrations of several constituents than the leachates from the reference section with crushed rock. The leaching of the elements of interest (Cr, Mo, Ni, Zn) reached peak concentrations during the second and fourth (Cu) years and decreased over the observation period to levels below the Swedish recommended values. Carbonation of the concrete aggregates caused a substantial but short-term increase in the leaching of oxyanions such as chromate. The environmental risks related to element leaching are highest at the beginning of the road life. Ageing of materials or pre-treatment through leaching is needed prior to their use in construction to avoid peak concentrations. Also, the design of road constructions should be adjusted so that recycled materials are covered with low-permeability covers, which would minimize the exposure to atmospheric precipitation and weathering. Copyright © 2017 Elsevier Ltd. All rights reserved.

Experimental evaluation of neural probe’s insertion induced injury based on digital image correlation method

Energy Technology Data Exchange (ETDEWEB)

Zhang, Wenguang, E-mail: zhwg@sjtu.edu.cn; Ma, Yakun; Li, Zhengwei [State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240 (China)

2016-01-15

Purpose: The application of neural probes in clinic has been challenged by probes’ short lifetime when implanted into brain tissue. The primary goal is to develop an evaluation system for testing brain tissue injury induced by neural probe’s insertion using microscope based digital image correlation method. Methods: A brain tissue phantom made of silicone rubber with speckle pattern on its surface was fabricated. To obtain the optimal speckle pattern, mean intensity gradient parameter was used for quality assessment. The designed testing system consists of three modules: (a) load module for simulating neural electrode implantation process; (b) data acquisition module to capture micrographs of speckle pattern and to obtain reactive forces during the insertion of the probe; (c) postprocessing module for extracting tissue deformation information from the captured speckle patterns. On the basis of the evaluation system, the effects of probe wedge angle, insertion speed, and probe streamline on insertion induced tissue injury were investigated. Results: The optimal quality speckle pattern can be attained by the following fabrication parameters: spin coating rate—1000 r/min, silicone rubber component A: silicone rubber component B: softener: graphite = 5 ml: 5 ml: 2 ml: 0.6 g. The probe wedge angle has a significant effect on tissue injury. Compared to wedge angle 40° and 20°, maximum principal strain of 60° wedge angle was increased by 40.3% and 87.5%, respectively; compared with a relatively higher speed (500 μm/s), the maximum principle strain within the tissue induced by slow insertion speed (100 μm/s) was increased by 14.3%; insertion force required by probe with convex streamline was smaller than the force of traditional probe. Based on the experimental results, a novel neural probe that has a rounded tip covered by a biodegradable silk protein coating with convex streamline was proposed, which has both lower insertion and micromotion induced tissue

Oxidative stress following traumatic brain injury: enhancement of ...

African Journals Online (AJOL)

neuronal loss following traumatic brain injury and presents experimental and clinical evidence of the role of exogenous antioxidants as neuroprotectants. Method: We reviewed published literature on reactive oxygen species and their role in experimental and clinical brain injuries in journals and the Internet using Yahoo ...

Dissolution of Intact, Divided and Crushed Circadin Tablets: Prolonged vs. Immediate Release of Melatonin

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Hui Ming Chua

2016-01-01

Full Text Available Circadin 2 mg prolonged-release tablet is the only licensed melatonin product available in the UK. Circadin is indicated for patients with primary insomnia aged 55 and over, but is more widely used “off-label” to treat sleep disorders especially in the paediatric population. Children and older people often have difficulty swallowing tablets and dividing the tablet is sometimes required to ease administration. The aim of this study was to measure the release profile of melatonin from Circadin tablets when divided or crushed, and compare this with release from intact tablets. Dissolution testing was also performed for unlicensed melatonin products for comparison. Dissolution tests were performed using the pharmacopoeial paddle apparatus, with melatonin release analyzed by high performance liquid chromatography. Melatonin content, hardness, friability, and disintegration of the products were also evaluated. The prolonged release of melatonin from Circadin tablets was unlike that of any other product tested. When divided into halves, Circadin preserved most of the prolonged-release characteristic (f2 = 58, whereas quarter-cut and crushed tablet had a more immediate melatonin release profile. Circadin is significantly less expensive and should be preferred to unlicensed medicines which are not pharmaceutically equivalent and offer less quality assurance.

Experimental sharp force injuries to ribs: Multimodal morphological and geometric morphometric analyses using micro-CT, macro photography and SEM.

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Komo, Larissa; Grassberger, Martin

2018-07-01

Tool marks on bones induced by knife blades can be analysed morphometrically in order to enable an allocation of the suspected "inflicting weapon" to the particular morphology of the bone lesions. Until now, geometric morphometrics has not been used to analyse the morphology of knife lesions on fleshed bones in detail. By using twelve experimental knives and a drop weight tower, stab/cut injuries were inflicted on untreated pig ribs. The morphology of the experimentally produced lesions was subsequently recorded with three imaging techniques (μCT, macro photography and SEM) and analysed with different morphometric software (Amira, tps and Morpheus). Based on the measured distances between the walls of the kerf marks, which corresponded to the thickness of the blade, one could conclude to the respective blade thickness with a deviation of max. ±0.35mm and match the injuries to the knives. With subsequent reanalysis after maceration, an average shrinkage factor up to 8.6% was observed. Among the three imaging techniques used in this study, μCT was the most accurate and efficient technique, particularly because it represented the only non-destructive modality to document injuries without maceration, even though μCT is more expensive and time-consuming as well as less accessible than a macro SLR-camera or a SEM. For optimal characterizations of the blades' and kerfs' shapes the software tps proofed to be the best choice. Accordingly, geometric morphometrics could serve as a tool in forensic investigations concerning kerf marks. Copyright © 2018 Elsevier B.V. All rights reserved.

Equipment for biomass. Dryers. Drying, crushing, aggregating of agro-industrial products; Materiels pour la biomasse, les secheurs, sechage, broyage, agglomeration de produits agro-industriels

Energy Technology Data Exchange (ETDEWEB)

Deur, O. [Promill, 28 - Serville (France)

1997-12-31

The French society Promill has developed complete units for the drying, crushing and aggregating of agro-industrial products (beet roots, agricultural wastes, lucerne, maize, etc.). Drying is conducted in a three-pass drum, using any type of fuel (fuel oil, gas, electric power, coal), and ensuring a thermal yield of 680 kCal/kg and ash emission rates complying with French and European legislation. Granulation is conducted with vapour addition, with a granulate flowrate reaching 15 T/h. Crushing is carried out in a hammer mill

Early occupational hearing loss of workers in a stone crushing industry: our experience in a developing country.

Science.gov (United States)

Kitcher, Emmanuel D; Ocansey, Grace; Tumpi, Daniel A

2012-01-01

Noise-induced hearing loss (NIHL) is an irreversible sensorineural hearing loss associated with exposure to high levels of excessive noise. This paper aims to assess the prevalence of early NIHL and the awareness of the effects of noise on health among stone crushing industry workers. This was a comparative cross-sectional study in Ghana of 140 workers from the stone crushing industry compared with a control group of 150 health workers. The stone workers and controls were evaluated using a structured questionnaire, which assessed symptoms of hearing loss, tinnitus, knowledge on the health hazards associated with work in noisy environment and the use of hearing protective device. Pure tone audiometric assessment was carried out for stone workers and controls. Noise levels at the work stations of the stone workers and of the controls were measured. Statistical Analysis of data was carried out using SPSS package version 16. The mean age of stone workers and controls was 42.58±7.85 and 42.19±12 years, respectively. Subjective hearing loss occurred in 21.5% of the workers and in 2.8% of the controls. Tinnitus occurred in 26.9% of stone workers and 21.5% of controls, while 87.5% stone workers had sound knowledge on the health hazards of a noisy environment. Early NIHL in the left ear occurred in 19.3% of the stone workers compared with 0.7% in controls and in the right ear, it occurred in 14.3% of the stone workers and in 1.3% of the controls; Pstone crushing workers is about 19.3% for the left ear and 14.3% for the right ear.

Neuroprotective effects of agmatine in experimental peripheral nerve injury in rats: a prospective randomized and placebo-controlled trial.

Science.gov (United States)

Sezer, Aykut; Guclu, Bulent; Kazanci, Burak; Cakir, Murteza; Coban, Mustafa Kemal

2014-01-01

The purpose of this study was to demonstrate the activity of agmatine, an inducible nitric oxide synthase (iNOS) inhibitor and selective N-methyl-D-aspartate receptor (NMDAR) antagonist, on reducing tissue damage in distal part of traumatic nerve in an experimental rat peripheral nerve injury model. Sciatic nerves of 30 Sprague Dawley male rats were used. Rats were divided into 5 groups; group 1 (n=6), control group; group 2 (n=6), axonotmesis + placebo group; group 3 (n=6), axonotmesis + 50 mg/kg agmatine treatment group; group 4 (n=6), neurotmesis + placebo group; group 5 (n=6), neurotmesis + 50 mg/kg agmatine treatment group. Axonolysis, axon degeneration, edema, hemorrhage, and inflammation were evaluated in histopathologic examinations of all the groups. When group 2 was compared with group 3 in histopathologic sections, axonolysis was less in group 3 (p=0.007), as was axon degeneration (p=0.022) and edema (p=0.018). When group 4 was compared with group 5, axonolysis was less in group 5 (p=0.009), as was axon degeneration (p=0.006) and edema (p=0.021). This study demonstrated agmatine to have antioxidant and antineurotoxic effects in an experimental rat peripheral nerve injury model.

Evaluation of electrical aversion therapy for inappropriate sexual behaviour after traumatic brain injury: a single case experimental design study

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ter Mors, Bert Jan; van Heugten, Caroline M; van Harten, Peter N

2012-01-01

Inappropriate sexual behaviour after acquired brain injury is a severe complication. Evidence for effective treatment is not available. Electrical aversion therapy (EAT) is a behavioural therapeutic option used in persons with intellectual disabilities, which might be suitable for brain-injured individuals for whom other therapies are not effective. The effect of EAT in brain injury has not been investigated previously. A single case experimental design was used. In an ABBA (baseline-treatment-treatment-withdrawal) design the frequency of the target behaviour (ie, inappropriate sexual behaviour) in a 40-year-old man was measured daily. A total of 551 measurements were recorded. A significant reduction of the target behaviour was seen after the first treatment phase (baseline 12.18 (2.59) vs 3.15 (3.19) mean target behaviours daily); this reduction remained stable over time. We conclude that EAT was effective in this patient with inappropriate sexual behaviour due to severe brain injury. EAT can therefore be considered in therapy resistant inappropriate sexual behaviour in brain-injured patients. PMID:22922913

Multiple injuries after earthquakes: a retrospective analysis on 1,871 injured patients from the 2008 Wenchuan earthquake.

Science.gov (United States)

Lu-Ping, Zhao; Rodriguez-Llanes, Jose Manuel; Qi, Wu; van den Oever, Barbara; Westman, Lina; Albela, Manuel; Liang, Pan; Gao, Chen; De-Sheng, Zhang; Hughes, Melany; von Schreeb, Johan; Guha-Sapir, Debarati

2012-05-17

Multiple injuries have been highlighted as an important clinical dimension of the injury profile following earthquakes, but studies are scarce. We investigated the pattern and combination of injuries among patients with two injuries following the 2008 Wenchuan earthquake. We also described the general injury profile, causes of injury and socio-demographic characteristics of the injured patients. A retrospective hospital-based analysis of 1,871 earthquake injured patients, totaling 3,177 injuries, admitted between 12 and 31 May 2008 to the People's Hospital of Deyang city (PHDC). An electronic, webserver-based database with International Classification of Diseases (ICD)-10-based classification of earthquake-related injury diagnoses (IDs), anatomical sites and additional background variables of the inpatients was used. We analyzed this dataset for injury profile and number of injuries per patient. We then included all patients (856) with two injuries for more in-depth analysis. Possible spatial anatomical associations were determined a priori. Cross-tabulation and more complex frequency matrices for combination analyses were used to investigate the injury profile. Out of the 1,871 injured patients, 810 (43.3%) presented with a single injury. The rest had multiple injuries; 856 (45.8%) had two, 169 (9.0%) patients had three, 32 (1.7%) presented with four injuries, while only 4 (0.2%) were diagnosed with five injuries. The injury diagnoses of patients presenting with two-injuries showed important anatomical intra-site or neighboring clustering, which explained 49.1% of the combinations. For fractures, the result was even more marked as spatial clustering explained 57.9% of the association pattern. The most frequent combination of IDs was a double-fracture, affecting 20.7% of the two-injury patients (n = 177). Another 108 patients (12.6%) presented with fractures associated with crush injury and organ-soft tissue injury. Of the 3,177 injuries, 1,476 (46.5%) were

Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

Science.gov (United States)

Pitha, Ian F.; Nguyen, Cathy; Steinhart, Matthew R.; Nguyen, Thao D.; Pease, Mary Ellen; Oglesby, Ericka N.; Berlinicke, Cynthia A.; Mitchell, Katherine L.; Kim, Jessica; Jefferys, Joan J.

2015-01-01

Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. Methods We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone, enalapril, or no drug to test effects of inhibiting angiotensin receptors. IOP was monitored by Tonolab, and blood pressure was monitored by tail cuff device. RGC loss was measured in masked axon counts and RGC bodies by β-tubulin labeling. Scleral changes that could modulate RGC injury were measured including axial length, scleral thickness, and retinal layer thicknesses, pressure-strain behavior in inflation testing, and study of angiotensin receptors and pathways by reverse transcription polymerase chain reaction, Western blot, and immunohistochemistry. Results Losartan treatment prevented significant RGC loss (median loss = 2.5%, p = 0.13), while median loss with water, spironolactone, and enalapril treatments were 26%, 28% and 43%; p glaucoma eyes (p = 0.007). Losartan inhibited effects of glaucoma, including reduction in extracellular signal-related kinase activity and modification of glaucoma-related changes in scleral thickness and creep under controlled IOP. Conclusions The neuroprotective effect of losartan in mouse glaucoma is associated with adaptive changes in the sclera expressed at the optic nerve head. PMID:26505191

GGF2 is neuroprotective in a rat model of cavernous nerve injury-induced erectile dysfunction.

Science.gov (United States)

Burnett, Arthur L; Sezen, Sena F; Hoke, Ahmet; Caggiano, Anthony O; Iaci, Jennifer; Lagoda, Gwen; Musicki, Biljana; Bella, Anthony J

2015-04-01

Erectile dysfunction is a major complication of radical prostatectomy, commonly associated with penile neuropathy. In animal models of peripheral nerve injury, glial growth factor-2 (GGF2), a member of the neuregulin family of growth factors, has neuroprotective and neurorestorative properties, but this potential has not been established after cavernous nerve (CN) injury. The effectiveness of GGF2 in preserving axonal integrity and recovering erectile function in a rat model of radical prostatectomy-associated CN injury. Adult male Sprague-Dawley rats underwent bilateral CN crush injury (BCNI) or sham surgery. Rats were administered GGF2 (0.5, 5, or 15 mg/kg) or vehicle subcutaneously 24 hour pre and 24-hour post-BCNI, and once weekly for 5 weeks. Erectile function was assessed in response to electrical stimulation of the CN. CN survival was assessed by fluorogold retrograde axonal tracing in major pelvic ganglia (MPG). Unmyelinated axons in the CNs were quantitated by electron microscopy. Erectile function recovery, CN survival, and unmyelinated CN axon preservation in response to GGF2 treatment following BCNI. Erectile function was decreased (P cells in the MPG was reduced (P Schwann cells in the BCNI group was higher (P Schwann cell compared with the BCNI group. GGF2 promotes erectile function recovery following CN injury in conjunction with preserving unmyelinated CN fibers. Our findings suggest the clinical opportunity to develop GGF2 as a neuroprotective therapy for radical prostatectomy. © 2015 International Society for Sexual Medicine.

Effect of Aspirin on Spinal Cord Injury: An Experimental Study

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Hamed Reihani Kermani

2016-05-01

Full Text Available Aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. The existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (SCI. Therefore, we sought to investigate the putative effects of aspirin on experimental SCI. The weight-drop injury model was used to produce SCI in 100 albino Wistar rats. The animals were allocated to five groups: a control group, where the rats did not undergo any surgical or medical intervention except for anesthesia; a sham-treated group, where laminectomy was performed without SCI and no further therapy was administered; and three other groups, where the rats with SCI received low-dose aspirin [20 mg/kg], high-dose aspirin [80 mg/kg], and a vehicle, respectively. Half of the rats were sacrificed 24 hours later, and their spinal cords were excised for biochemical studies. The other rats were subjected to Basso, Beattie, and Bresnahan (BBB locomotor rating scale scoring once a week for 6 consecutive weeks. Aspirin decreased lipid peroxidation following SCI as the mean (± standard error catalase level was significantly higher in the high-dose aspirin group (46.10±12.01 than in the sham-treated group (16.07±2.42 and the vehicle-treated group (15.31±3.20 (P<0.05; P<0.05, respectively. Both of the groups treated with high-dose and low-dose aspirin demonstrated a higher mean BBB score than did the control group (P<0.001 and the sham-treated group (P<0.001. Our data provide evidence in support of the potential effects of aspirin in biochemical and neurobehavioral recovery after SCI.

Exercise training improves functional recovery and motor nerve conduction velocity after sciatic nerve crush lesion in the rat

NARCIS (Netherlands)

Gispen, W.H.; Meeteren, N.L.U.; Brakkee, J.H.; Hamers, F.P.T.; Helders, P.J.M.

1997-01-01

Objective: To observe the effects of exercise training on recuperation of sensorimotor function in the early phase of regeneration, and to monitor the long-term effects of exercise on electrophysiological aspects of the regenerating nerve. Design: After sciatic nerve crush in 20 male Wistar rats,

Effects of early nerve repair on experimental brachial plexus injury in neonatal rats.

Science.gov (United States)

Bourke, Gráinne; McGrath, Aleksandra M; Wiberg, Mikael; Novikov, Lev N

2018-03-01

Obstetrical brachial plexus injury refers to injury observed at the time of delivery, which may lead to major functional impairment in the upper limb. In this study, the neuroprotective effect of early nerve repair following complete brachial plexus injury in neonatal rats was examined. Brachial plexus injury induced 90% loss of spinal motoneurons and 70% decrease in biceps muscle weight at 28 days after injury. Retrograde degeneration in spinal cord was associated with decreased density of dendritic branches and presynaptic boutons and increased density of astrocytes and macrophages/microglial cells. Early repair of the injured brachial plexus significantly delayed retrograde degeneration of spinal motoneurons and reduced the degree of macrophage/microglial reaction but had no effect on muscle atrophy. The results demonstrate that early nerve repair of neonatal brachial plexus injury could promote survival of injured motoneurons and attenuate neuroinflammation in spinal cord.

Recent developments, new trends in seed crushing and oil refining

Directory of Open Access Journals (Sweden)

Kővári Katalin

2004-11-01

Full Text Available Oil processing was considered as slowly changing “traditional” industry but the recent decades’ developments and trends resulted in a lot of changes initiated by market, industry, environment protection and consumer needs. Driving force of the developments were centralization of the industry, more and more concerns on environmental impact, increased importance of food-feed safety, and last but not least research and development activity together with improved analytical capabilities. The presentation gives an overview on the results achieved on the field of the following areas: the criteria of applicability of physical refining of seed oils, solutions for proper degumming, the effect of seed pretreatment and crushing conditions on the crude oil quality, the importance and role of bleaching and active carbon treatment, the proper practice of deacidification/deodorization.

Intranasal insulin treatment of an experimental model of moderate traumatic brain injury.

Science.gov (United States)

Brabazon, Fiona; Wilson, Colin M; Jaiswal, Shalini; Reed, John; Frey, William H; Byrnes, Kimberly R

2017-09-01

Traumatic brain injury (TBI) results in learning and memory dysfunction. Cognitive deficits result from cellular and metabolic dysfunction after injury, including decreased cerebral glucose uptake and inflammation. This study assessed the ability of intranasal insulin to increase cerebral glucose uptake after injury, reduce lesion volume, improve memory and learning function and reduce inflammation. Adult male rats received a controlled cortical impact (CCI) injury followed by intranasal insulin or saline treatment daily for 14 days. PET imaging of [18F]-FDG uptake was performed at baseline and at 48 h and 10 days post-injury and MRI on days three and nine post injury. Motor function was tested with the beam walking test. Memory function was assessed with Morris water maze. Intranasal insulin after CCI significantly improved several outcomes compared to saline. Insulin-treated animals performed better on beam walk and demonstrated significantly improved memory. A significant increase in [18F]-FDG uptake was observed in the hippocampus. Intranasal insulin also resulted in a significant decrease in hippocampus lesion volume and significantly less microglial immunolabeling in the hippocampus. These data show that intranasal insulin improves memory, increases cerebral glucose uptake and decreases neuroinflammation and hippocampal lesion volume, and may therefore be a viable therapy for TBI.

A clinical trial to determine if corelease of morphine and naltrexone from crushed extended-release capsules induces withdrawal in opioid-dependent patients: a descriptive analysis of six patients.

Science.gov (United States)

Setnik, Beatrice; Roland, Carl L; Goli, Veeraindar; Sommerville, Kenneth; Webster, Lynn

2013-01-01

To evaluate whether intact or crushed doses of an extended-release formulation of morphine sulfate surrounding an inner core of sequestered naltrexone (MSN) induces signs and symptoms of withdrawal in opioid-dependent patients. Randomized, double-blind, two-way crossover study. Single center. Fourteen patients with chronic moderate-to-severe noncancer pain receiving opioids were enrolled into the study; six completed the maintenance and treatment phases prior to early study discontinuation for issues with manufacturing; eight discontinued: adverse effects (4), noncompliance (1), patient decision (1), study termination (2). Patients were titrated to a stable dose of MSN (ranging from 30/1.2 to 100/4.0 mg of morphine/naltrexone) that was used in the single-dose crossover evaluation of crushed and intact MSN. Clinical Opiate Withdrawal Scale (COWS). Clinically significant withdrawal (COWS ≥ 13) was observed with rapid onset (≤0.8 hours postdose) in three patients (50 percent) following treatment with crushed MSN at the highest doses administered of ≥60/2.4 mg. Although naltrexone exposure was negligible following exposure to intact MSN, increasing plasma levels of naltrexone and 6-β-naltrexol were associated with COWS score ≥13 in patients who received crushed MSN. COWS ≥ 13 was observed in one patient receiving intact MSN without quantifiable naltrexone concentrations. Crushing the MSN capsule may precipitate moderate-to-severe signs and symptoms of opioid withdrawal in opioid-dependent individuals. The negligible exposure to naltrexone following exposure to intact MSN supports that intact capsules may be taken safely without precipitating withdrawal in opioid-dependent individuals.

Early occupational hearing loss of workers in a stone crushing industry: Our experience in a developing country

Directory of Open Access Journals (Sweden)

Emmanuel D Kitcher

2012-01-01

Full Text Available Noise-induced hearing loss (NIHL is an irreversible sensorineural hearing loss associated with exposure to high levels of excessive noise. This paper aims to assess the prevalence of early NIHL and the awareness of the effects of noise on health among stone crushing industry workers. This was a comparative cross-sectional study in Ghana of 140 workers from the stone crushing industry compared with a control group of 150 health workers. The stone workers and controls were evaluated using a structured questionnaire, which assessed symptoms of hearing loss, tinnitus, knowledge on the health hazards associated with work in noisy environment and the use of hearing protective device. Pure tone audiometric assessment was carried out for stone workers and controls. Noise levels at the work stations of the stone workers and of the controls were measured. Statistical Analysis of data was carried out using SPSS package version 16. The mean age of stone workers and controls was 42.58±7.85 and 42.19±12 years, respectively. Subjective hearing loss occurred in 21.5% of the workers and in 2.8% of the controls. Tinnitus occurred in 26.9% of stone workers and 21.5% of controls, while 87.5% stone workers had sound knowledge on the health hazards of a noisy environment. Early NIHL in the left ear occurred in 19.3% of the stone workers compared with 0.7% in controls and in the right ear, it occurred in 14.3% of the stone workers and in 1.3% of the controls; P<0.005. In conclusion, the prevalence rate of early NIHL among stone crushing workers is about 19.3% for the left ear and 14.3% for the right ear.

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats

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Firas H Kobeissy

2016-11-01

Full Text Available Traumatic brain injury (TBI represents a critical health problem of which diagnosis, management and treatment remain challenging. TBI is a contributing factor in approximately 1/3 of all injury-related deaths in the United States. The Centers for Disease Control and Prevention (CDC estimate that 1.7 million TBI people suffer a TBI in the United States annually. Efforts continue to focus on elucidating the complex molecular mechanisms underlying TBI pathophysiology and defining sensitive and specific biomarkers that can aid in improving patient management and care. Recently, the area of neuroproteomics-systems biology is proving to be a prominent tool in biomarker discovery for central nervous system (CNS injury and other neurological diseases. In this work, we employed the controlled cortical impact (CCI model of experimental TBI in rat model to assess the temporal-global proteome changes after acute (1 day and for the first time, subacute (7 days, post-injury time frame using the established CAX-PAGE LC-MS/MS platform for protein separation combined with discrete systems biology analyses to identify temporal biomarker changes related to this rat TBI model. Rather than focusing on any one individual molecular entities, we used in silico systems biology approach to understand the global dynamics that govern proteins that are differentially altered post-injury. In addition, gene ontology analysis of the proteomic data was conducted in order to categorize the proteins by molecular function, biological process, and cellular localization. Results show alterations in several proteins related to inflammatory responses and oxidative stress in both acute (1 day and subacute (7 days periods post TBI. Moreover, results suggest a differential upregulation of neuroprotective proteins at 7-days post-CCI involved in cellular functions such as neurite growth, regeneration, and axonal guidance. Our study is amongst the first to assess temporal neuroproteome

Crushing of Subglacial Lake Sediment as a Source of Bio-utilisable Gases.

Science.gov (United States)

Gill Olivas, B.; Telling, J.; Michaud, A. B.; Skidmore, M. L.; Priscu, J. C.; Tranter, M.

2017-12-01

Recent research has shown microbial ecosystems exist under glaciers and ice sheets. The sources of energy to support these ecosystems are still not fully understood, particularly beneath the Antarctic Ice Sheet, where direct access to the atmosphere and in-washed organic matter and oxidising agents does not occur. Hence, sub-ice sheet energy sources are restricted to those in subglacial environments, except for ice-margin environments. This study focuses on sediments from Subglacial Lake Whillans (SLW), the first subglacial lake to be directly and cleanly sampled. Sediment from three depths in a shallow core extracted from SLW were used to assess the possible energy contributions from mechanochemical reactions to this subglacial ecosystem. To do this, the samples were crushed under an anoxic atmosphere using a ball mill. The sediments were then transferred into serum bottles under anoxic conditions. They were wetted and the headspace gas was subsequently sampled and analysed during a 40 day incubation. Results show the release of substantial amounts of hydrogen, which could potentially serve as an abiotic source of energy to microbes, in particular, methanogenic archaea. Significant amounts of short chain hydrocarbons (including methane and ethylene), possibly from the reactivation of ancient organic carbon, were also observed. Crushed samples showed a significant concentration of hydrogen peroxide produced on contact with water, as well as significant amounts of Si radicals, showing comminution of these sediments unlocks the potential for a wide range of redox conditions and reactions to develop within glacially eroded sediment under ice. This in turn provides a previously overlooked source of nutrients and energy for microbes to utilise.

Injury/Fatality-Causing Incidents Involving the Rearward Movement of Agricultural Machinery: Types, Causes, and Preventive Measures

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Shawn G. Ehlers

2017-02-01

Full Text Available The research reported here sought to more fully understand the types and causative factors of injury/fatality incidents resulting from the rearward-movement of tractors and other self-propelled agricultural machinery, with the view that such findings might lead to the development, improvement, and/or better utilization of safety procedures, design principles, and technologies that would prevent—or at least markedly reduce—their occurrence. Thus, the scope of this study focused only on rearward-travel (not mechanical malfunction incidents, and principally on agricultural equipment (although cases involving similar equipment in industrial or construction settings were also drawn upon. Applying these two criteria, a search of published and online sources uncovered more than 100 documented cases, 35 of which could clearly be identified as rearward-movement incidents, of which 28 (80% were fatal. Each of these 35 cases were then assessed, based on the type of machine, type of worksite, and type/description of incident (i.e., ‘scenario’, which fell into one of three distinct categories or classifications—(1 co-worker run over/crushed/otherwise injured because operator loses visual contact with co-worker; (2 bystander run over/crushed/otherwise injured because operator is unaware of bystander’s presence; and (3 operator run over/crushed/otherwise injured because operator loses visual contact with, or is unaware of, a stationary object or a hazard. Then, from each scenario, a representative incident (i.e., case study was selected for a more in-depth analysis. The collective findings, from these three case studies and all 35 machinery rearward-movement incidents, were as follows: (1 The ‘victim’ could be the machine operator as well as a co-worker or a bystander; (2 The specific site of the co-worker or bystander injury/fatality was at the base of the machine’s rear tires or tracks, at the hitching point, or behind a towed implement; (3

Effect of Calcium Oxide on the Crushing Strength, Reduction, and Smelting Performance of High-Chromium Vanadium–Titanium Magnetite Pellets

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Gongjin Cheng

2017-05-01

Full Text Available The effect of calcium oxide on the crushing strength, reduction, and smelting performance of high-chromium vanadium–titanium magnetite pellets (HCVTMP was studied in this work. The main characterization methods of an electronic universal testing machine (EUTM, X-ray fluorescent (XRF, inductively-coupled plasma-atomic emission spectroscopy (ICP-AES, X-ray diffraction (XRD, and scanning electron microscope-energy disperse spectroscopy (SEM-EDS were employed. The crushing strength was affected by the mineral phases generated during oxidative baking and the subsequently-formed pellet microstructures owing to CaO addition. The reduction and smelting properties of HCVTMP with different CaO additives were measured and characterized with different softening-melting-dripping indices. Although HCVTMP showed the highest crushing strength with CaO addition of ca. 2 wt %, more CaO addition may be needed to achieve high permeability of the furnace burdens and a good separation condition of the slag and melted iron. In the formation process of the slag and melted iron, it can be determined that CaO could have a relationship with the transformation behavior of Cr, V, and Ti to some extent, with respect to the predominant chemical composition analysis of ICP-AES and XRF. With the microscopic examination, the restraining formation of Ti(C,N and the promoting formation of CaTiO3 are in accordance with the improved melting-dripping indices, including the decrease of the maximum external static load and gas permeability, and the increase of the melting-dripping zone and dripping difficulty.

Injury-related hospital admissions of military dependents compared with similarly aged nonmilitary insured infants, children, and adolescents.

Science.gov (United States)

Pressley, Joyce C; Dawson, Patrick; Carpenter, Dustin J

2012-10-01

Military deployment of one or both parents is associated with declines in school performance, behavioral difficulties, and increases in reported mental health conditions, but less is known regarding injury risks in pediatric military dependents. Kid Health Care Cost and Utilization Project 2006 (KID) was used to identify military dependents aged 0.1 year to 17 years through expected insurance payer being CHAMPUS, Tricare, or CHAMPVA (n = 12,310) and similarly aged privately insured nonmilitary in CHAMPUS, Tricare, or CHAMPVA states (n = 730,065). Mental health diagnoses per 1,000 hospitalizations and mechanisms of injury per 1,000 injury-related hospitalizations are reported. Unweighted univariate analyses used Fisher's exact, χ(2), and analysis of variance tests for significance. Odds ratios are age and sex adjusted with 95% confidence intervals. Injury-related admissions were higher in military than in nonmilitary dependents (15.5% vs. 13.2%, p sex-adjusted motor vehicle occupant and pedestrian injuries were significantly lower in all-age military dependents but not in age-stratified categories. Very young military dependents had higher all-cause injury admissions (p < 0.0001), drowning/near drowning (p < 0.0001), and intracranial injury (p < 0.0001) and showed a tendency toward higher suffocation (p = 0.055) and crushing injury (p = 0.065). Military adolescents and teenagers had higher suicide/suicide attempts (p = 0.0001) and poisonings from medicinal substances (p = 0.0001). Mental health diagnoses were significantly higher in every age category of military dependents. All-cause in-hospital mortality tended to be greater in military than in nonmilitary dependents (p = 0.052). This study suggests that military dependents are a vulnerable population with special needs and provides clues to areas where injury prevention professionals might begin to address their needs. Prognostic/epidemiologic study, level II.

Neuropsychiatric Symptom Modeling in Male and Female C57BL/6J Mice after Experimental Traumatic Brain Injury

Science.gov (United States)

Tucker, Laura B.; Burke, John F.; Fu, Amanda H.

2017-01-01

Abstract Psychiatric symptoms such as anxiety and depression are frequent and persistent complaints following traumatic brain injury (TBI). Modeling these symptoms in animal models of TBI affords the opportunity to determine mechanisms underlying behavioral pathologies and to test potential therapeutic agents. However, testing these symptoms in animal models of TBI has yielded inconsistent results. The goal of the current study was to employ a battery of tests to measure multiple anxiety- and depressive-like symptoms following TBI in C57BL/6J mice, and to determine if male and female mice are differentially affected by the injury. Following controlled cortical impact (CCI) at a parietal location, neither male nor female mice showed depressive-like symptoms as measured by the Porsolt forced-swim test and sucrose preference test. Conclusions regarding anxiety-like behaviors were dependent upon the assay employed; CCI-induced thigmotaxis in the open field suggested an anxiogenic effect of the injury; however, results from the elevated zero maze, light-dark box, and marble-burying tests indicated that CCI reduced anxiety-like behaviors. Fewer anxiety-like behaviors were also associated with the female sex. Increased levels of activity were also measured in female mice and injured mice in these tests, and conclusions regarding anxiety should be taken with caution when experimental manipulations induce changes in baseline activity. These results underscore the irreconcilability of results from studies attempting to model TBI-induced neuropsychiatric symptoms. Changes in injury models or better attempts to replicate the clinical syndrome may improve the translational applicability of rodent models of TBI-induced anxiety and depression. PMID:27149139

Cyklister draebt af højresvingende lastbiler--retspatologiske fund

DEFF Research Database (Denmark)

Munkholm, Julie; Thomsen, Asser Hedegård; Lynnerup, Niels

2007-01-01

severe as to be described as complete crushing (conquassatio). CONCLUSION: In traffic accidents involving cyclists and right-turning HGVs, the cyclist is more often run-over rather than merely hit by the HGV. This mechanism of injury is crucial for both the severity and the distribution of injuries....... In 20 cases (80%), death had occurred instantly. Also in 20 cases (80%), injuries in at least three body regions were found at autopsy. There were no cases with injuries in only one body region. There were fewest cases with head/neck injuries. In 16 cases, injuries in one or more body regions were so....... This is reflected in this study by the number of multiple body regions involved, the number of complete crushing injuries and by the number of cases where death had occurred instantly. Future efforts should focus on the prevention of these accidents. Udgivelsesdato: 2007-Jan-15...

Protective effects of ischemic postconditioning on intestinal

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DING Jun-tao

2011-04-01

Full Text Available 【Abstract】Objective: To explore the protective effects of two types of ischemic postconditioning (IP on intestinal mucosa barrier in rabbits with crush injury of the hind limb. Methods: This study was conducted between August and December 2008 in the Department of Trauma Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. The model of crush injury to the hind limb of rabbits was firstly developed by a 25 kg object with the right hind limbs fixed by wooden splints, and then two types of IP were established, including occluding/opening the common iliac artery and vein alternatively (traditional IP, IP A and binding/loosening the proximum of the injured hind limb alternatively (modified IP, IP B. Thirty-six male New Zealand white rabbits were randomly divided into three groups: IP A group, IP B group and control group, with 12 rabbits in each group. The serum levels of diamine oxidase (DAO and intestinal fatty acid-binding protein (I-FABP were detected at 2, 6, 12 and 24 hours after injury. Pathological changes of ileum were examined at 24 hours after injury. Results: The serum levels of I-FABP at 2, 6, 12 and 24 hours after injury in both IP A and IP B groups had a significant decrease, compared with control group. DAO levels also showed the same change trend at 2 and 6 hours after injury, but showed no significant difference between two IP groups. No difference in pathological changes of ileum was found among the three groups. Conclusions: IP can protect intestinal mucosa barrier function on the model of hind limb crush injury in rabbits. Meanwhile the modified IP B shows the same protection as the traditional IP A, and is worth applying in clinic. Key words: Ischemic postconditioning; Crush syndrome; Intestinal mucosa

Nociceptive DRG neurons express muscle lim protein upon axonal injury.

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Levin, Evgeny; Andreadaki, Anastasia; Gobrecht, Philipp; Bosse, Frank; Fischer, Dietmar

2017-04-04

Muscle lim protein (MLP) has long been regarded as a cytosolic and nuclear muscular protein. Here, we show that MLP is also expressed in a subpopulation of adult rat dorsal root ganglia (DRG) neurons in response to axonal injury, while the protein was not detectable in naïve cells. Detailed immunohistochemical analysis of L4/L5 DRG revealed ~3% of MLP-positive neurons 2 days after complete sciatic nerve crush and maximum ~10% after 4-14 days. Similarly, in mixed cultures from cervical, thoracic, lumbar and sacral DRG ~6% of neurons were MLP-positive after 2 days and maximal 17% after 3 days. In both, histological sections and cell cultures, the protein was detected in the cytosol and axons of small diameter cells, while the nucleus remained devoid. Moreover, the vast majority could not be assigned to any of the well characterized canonical DRG subpopulations at 7 days after nerve injury. However, further analysis in cell culture revealed that the largest population of MLP expressing cells originated from non-peptidergic IB4-positive nociceptive neurons, which lose their ability to bind the lectin upon axotomy. Thus, MLP is mostly expressed in a subset of axotomized nociceptive neurons and can be used as a novel marker for this population of cells.

The effect of butyric acid with autogenous omental graft on healing of experimental Achilles tendon injury in rabbits.

Science.gov (United States)

Jahani, S; Moslemi, H R; Dehghan, M M; Sedaghat, R; Mazaheri Nezhad, R; Rezaee Moghaddam, D

2015-01-01

In this study, the role of local injection of butyric acid (BA) with autogenous omental graft was evaluated in healing of experimental Achilles tendon injury in rabbits. Nine adult male New Zealand rabbits were anesthetized and a partial thickness tenotomy was created on both hindlimbs. In treated group, omental graft was secured in place using BA soaked polygalactin 910 suture. In control group, the graft was sutured without BA. Butyric acid and normal saline were injected daily to treatment and control groups for three days, respectively. Based on the findings, on day 15 after injury, the tendon sections showed that healing rate in BA treated group was higher than that in control group. Furthermore, at days 28 and 45, comparison between BA treated and control groups demonstrated that BA increased the healing rate but with no significance. In summary, results of this study show that application of BA with autogenous omental graft can improve healing process of damaged Achilles tendon.

Degeneration and regeneration of motor and sensory nerves: a stereological study of crush lesions in rat facial and mental nerves.

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Barghash, Z; Larsen, J O; Al-Bishri, A; Kahnberg, K-E

2013-12-01

The aim of this study was to evaluate the degeneration and regeneration of a sensory nerve and a motor nerve at the histological level after a crush injury. Twenty-five female Wistar rats had their mental nerve and the buccal branch of their facial nerve compressed unilaterally against a glass rod for 30s. Specimens of the compressed nerves and the corresponding control nerves were dissected at 3, 7, and 19 days after surgery. Nerve cross-sections were stained with osmium tetroxide and toluidine blue and analysed using two-dimensional stereology. We found differences between the two nerves both in the normal anatomy and in the regenerative pattern. The mental nerve had a larger cross-sectional area including all tissue components. The mental nerve had a larger volume fraction of myelinated axons and a correspondingly smaller volume fraction of endoneurium. No differences were observed in the degenerative pattern; however, at day 19 the buccal branch had regenerated to the normal number of axons, whereas the mental nerve had only regained 50% of the normal number of axons. We conclude that the regenerative process is faster and/or more complete in the facial nerve (motor function) than it is in the mental nerve (somatosensory function). Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Talar injuries--the orthopaedic challenge.

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Lesić, Aleksandar R; Zagorac, Slavisa G; Bumbasirević, Marko Z

2012-01-01

Injuries of the talus represents an important part of the foot and ankle trauma. Since talar bone connect the lower limb and foot, the sequelas of its trauma could have significant influence on the function of the whole lower limb and gait. The specific vascularization of the talus results in delayed union and even in the avascular necrosis. The diagnosis of the fractures of the talus can be made on the x-rays, but sometimes real picture of the fracture pattern can be seen only in the CT scans. Ocult fractures such as osteochondral fractures and avascular necrosis can be exactly detected on MRI in aim not to be overlookded as the ankle sprain diagnosis. The precise reduction and stable internal fixation is mandatory in the treatment to enable the anatomical position of the talonavicular, talocrural and subtalar joint and to make possible early motion and rehabilitation, without weight bearing. On the other hand, crushed fractures, open fractures and the Hawkins III-IV fractures with the dislocations of the talar body sometimes needs salvage procedures like Blair or tibio-talar or tibio-calcaneal fusion.

MR imaging with Gd-DTPA enhancement in experimental acute injury of the spinal cord

International Nuclear Information System (INIS)

Hackney, D.B.; Asato, R.; Joseph, P.M.; McGrath, J.T.; Grossman, R.I.; Shetty, A.

1986-01-01

The authors performed MR imaging with Gd-DTPA enhancement in adult male Sprague-Dawley rats, with experimentally induced acute spinal cored injuries. After epidural compression of the spinal cored the pathologic changes of acute cord contusion were allowed to develop for 30 minutes to 4 hours. MR imaging was then performed at 1.4 T. Both short spin-echo (TR = 400 msec, TE = 15-20 msec) and long spin-echo (TR = 2,000 msec, TE = 100 msec) images were obtained. After the initial imaging, Gd-DTPA (0.1 mmol/kg) and Evans blue dye were administered intravenously and imaging was repeated. Enhancement of normal central gray matter was consistently observed. However, neither pathologic enhancement on MR images nor extravasation of Evans blue dye on histologic inspection were identified

Gene Expression Analysis to Assess the Relevance of Rodent Models to Human Lung Injury.

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Sweeney, Timothy E; Lofgren, Shane; Khatri, Purvesh; Rogers, Angela J

2017-08-01

The relevance of animal models to human diseases is an area of intense scientific debate. The degree to which mouse models of lung injury recapitulate human lung injury has never been assessed. Integrating data from both human and animal expression studies allows for increased statistical power and identification of conserved differential gene expression across organisms and conditions. We sought comprehensive integration of gene expression data in experimental acute lung injury (ALI) in rodents compared with humans. We performed two separate gene expression multicohort analyses to determine differential gene expression in experimental animal and human lung injury. We used correlational and pathway analyses combined with external in vitro gene expression data to identify both potential drivers of underlying inflammation and therapeutic drug candidates. We identified 21 animal lung tissue datasets and three human lung injury bronchoalveolar lavage datasets. We show that the metasignatures of animal and human experimental ALI are significantly correlated despite these widely varying experimental conditions. The gene expression changes among mice and rats across diverse injury models (ozone, ventilator-induced lung injury, LPS) are significantly correlated with human models of lung injury (Pearson r = 0.33-0.45, P human lung injury. Predicted therapeutic targets, peptide ligand signatures, and pathway analyses are also all highly overlapping. Gene expression changes are similar in animal and human experimental ALI, and provide several physiologic and therapeutic insights to the disease.

Optimising processes of discontinuous loading and continuous transportation through mobile crushing plants; Prozessoptimierung bei diskontinuierlicher Beladung und kontinuierlichem Transport durch mobile Brecheranlagen

Energy Technology Data Exchange (ETDEWEB)

Christoph, B.M. [ThyssenKrupp Foerdertechnik GmbH, Essen (Germany)

2006-10-15

With its current development stage, the fully mobile crushing plant has reached the same level of mobility and capability as rope shovel and hydraulic excavators. Hence, this machine becomes an important link between discontinuous loading and continuous transportation in order to optimise surface mine operations which includes the sequences 'loosen', 'load' and 'transport'. Due to the increased availability of the crushing plant, the efficiency of the entire process rises. In addition, due to the central process control by the excavator operator, personnel cost can be saved. Consequently, the targets for increased process efficiency mentioned at the beginning of the presentation are fulfilled as fewer personnel can reach a higher degree of machine utilisation. (orig.)

The changing face of oilsands mining : mobile crushing systems on the way

Energy Technology Data Exchange (ETDEWEB)

Cook, D.L.M.

2007-06-15

The mobile crushing system (MCS) is a new technology used in oil sand mining. With MCS, the crusher is moved right to the mine face where it is continuously loaded by shovel. The ore is then crushed on site and transported by a mobile conveyor for further processing. MMD Mineral Sizing (Canada) and Krupp Canada are the only 2 manufacturers that currently build MCS for the oilsands sector. Suncor, Albian Sands and Syncrude Canada are the 3 major oilsands operators currently using MCS. The benefits and challenges of MCS were presented. The use of large mobile surface mining equipment such as the MCS means that ground stability issues associated with large mobile truck and shovel mining operations will be reduced. In addition, given the current worker shortage in the mining industry, using single-stream mobile surface mining equipment means operators can reduce their labour force. However, some challenges remain. The sheer size and weight of the unit means it can deform the ground surface and sink under adverse conditions. Alternative tire and suspension concepts that may alleviate some of these stability issues are currently being researched. Other issues that may affect the performance of MCS include the oil sand density and viscosity around material flow. Syncrude Canada is considering the use of MCS technology to mitigate common oilsands-related environmental issues. It is also testing compact slurry preparation technology in which shovels will feed the oilsands directly into a MCS and then into the in-pit bitumen production system slurry equipment. The MCS unit at Suncor's mine cost $150 million. It has been running at 5,000 tonnes of ore per hour, equivalent to 15 loads of ore in the large trucks. Given the success of the unit, plans are in place for 5 more units to be in operation over the next 5 years. 4 figs.

First aid practices, beliefs, and sources of information among caregivers regarding paediatric burn injuries in Harare, Zimbabwe: A cross-sectional study.

Science.gov (United States)

Chirongoma, Farai; Chengetanai, Samson; Tadyanemhandu, Cathrine

2017-06-01

While burns take seconds to occur, injuries incurred result in pain and undesirable long term effects that might take a lifetime to overcome. The study was carried out to determine the measures of first aid delivered by caregivers after a burn injury and sources of the information. A cross- sectional study was carried out over a period of 3 months at two central hospitals in Harare. A questionnaire was administered to the caregivers of children within the age group of 0-60 months admitted in burns wards to elicit information on the circumstances of the burn injury and the first aid methods which were administered. Out of the 50 children who were recruited, 54.0% were females and the mean age was 29.5 months (SD= 15.5). After the burn injury 30(60.0%) of the caregivers, cooled the burn injury with cold running water whilst some caregivers also applied eggs, margarine and some traditional herbs as first aid. The other practices reported by the caregivers included use of urine and crushed cockroaches after burn injury in 40 (80.0%) whilst 20 (40.0%) reported used aloe vera gel after a burn injury. About half of the caregivers got first aid information mainly from family members and very few indicated that the information was obtained from mass media, 3 (6.0%). The first aid measures used by the majority of caregivers were either incomplete or inadequate. Although some caregivers had adequate knowledge of what to do after an injury, there still was widespread use of alternatives therapies in burn management.

Acute pulmonary injury induced by experimental muscle trauma Lesão pulmonar aguda induzida por trauma muscular experimental

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Márcia Andréa da Silva Carvalho Sombra

2011-01-01

Full Text Available PURPOSE: To develop an easily reproducible model of acute lung injury due to experimental muscle trauma in healthy rats. METHODS: Eighteen adult Wistar rats were randomized in 3 groups (n=6: G-1- control, G-2 - saline+trauma and G-3 - dexamethasone+trauma. Groups G-1 and G-2 were treated with saline 2,0ml i.p; G-3 rats were treated with dexamethasone (DE (2 mg/kg body weight i.p.. Saline and DE were applied 2h before trauma and 12h later. Trauma was induced in G-2 and G-3 anesthetized (tribromoethanol 97% 100 ml/kg i.p. rats by sharp section of anterior thigh muscles just above the knee, preserving major vessels and nerves. Tissue samples (lung were collected for myeloperoxidase (MPO assay and histopathological evaluation. RESULTS: Twenty-four hours after muscle injury there was a significant increase in lung neutrophil infiltration, myeloperoxidase activity and edema, all reversed by dexamethasone in G-3. CONCLUSION: Trauma by severance of thigh muscles in healthy rats is a simple and efficient model to induce distant lung lesions.OBJETIVO: Desenvolver um modelo facilmente reprodutível de lesão pulmonar aguda decorrente de trauma muscular experimental em ratos sadios. MÉTODOS: Dezoito ratos Wistar adultos foram randomizados em 3 grupos (n=6: G-1-controle, G-2 - trauma+salina e G-3 - trauma+dexametasona. Grupos G-1 e G-2 foram tratados com salina 2,0 ml ip, G-3 ratos foram tratados com dexametasona (DE (2 mg/kg peso corporal ip. Salina e DE foram aplicadas 2h antes e 12h depois do trauma. Trauma foi induzido em ratos G-2 e G-3 anestesiados (tribromoetanol 97% de 100 ml/kg, i.p. por secção da musculatura anterior da coxa logo acima da articulação do joelho, preservando os grandes vasos e nervos. Amostras de tecido (pulmão foram coletadas para avaliação da mieloperoxidase (MPO, e exames histopatológicos. RESULTADOS: Vinte e quatro horas após a indução da lesão muscular houve um aumento significativo na infiltração de neutr

Influence of variables on the consolidation and unconfined compressive strength of crushed salt: Technical report

International Nuclear Information System (INIS)

Pfeifle, T.W.; Senseny, P.E.; Mellegard, K.D.

1987-01-01

Eight hydrostatic compression creep tests were performed on crushed salt specimens fabricated from Avery Island dome salt. Following the creep test, each specimen was tested in unconfined compression. The experiments were performed to assess the influence of the following four variables on the consolidation and unconfined strength of crushed salt: grain size distribution, temperature, time, and moisture content. The experiment design comprised a half-fraction factorial matrix at two levels. The levels of each variable investigated were grain size distribution, uniform-graded and well-graded (coefficient of uniformity of 1 and 8); temperature 25 0 C and 100 0 C; time, 3.5 x 10 3 s and 950 x 10 3 s (approximately 60 minutes and 11 days, respectively); and moisture content, dry and wet (85% relative humidity for 24 hours). The hydrostatic creep stress was 10 MPa. The unconfined compression tests were performed at an axial strain rate of 1 x 10 -5 s -1 . Results show that the variables time and moisture content have the greatest influence on creep consolidation, while grain size distribution and, to a somewhat lesser degree, temperature have the greatest influence on total consolidation. Time and moisture content and the confounded two-factor interactions between either grain size distribution and time or temperature and moisture content have the greatest influence on unconfined strength. 7 refs., 7 figs., 11 tabs

Alterações vesicais na lesão medular experimental em ratos Urinary bladder changes in experimental spinal cord injury

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Fernando Meyer

2003-06-01

Full Text Available O trauma raquemedular é uma das lesões traumáticas com maior impacto sobre a sociedade, o que faz com que enormes investimentos sejam feitos em estudos visando sua cura. Para a realização de pesquisas sobre lesão medular, é necessário que se utilize um modelo reprodutível desta lesão. A padronização de um sistema de lesão medular experimental provoca alterações não só no sistema nervoso mas também sistêmicas. OBJETIVO: O presente estudo visa avaliar as alterações vesicais na fase aguda da lesão medular experimental. MÉTODOS Foram utilizados 34 ratos Wistar machos divididos em grupo controle (A e grupo experimento (B. Enquanto os animais do grupo B foram submetidos à laminectomia no nível T9-T10 seguida de lesão medular, os do grupo A (n=4 foram submetidos somente à laminectomia. Os animais do grupo B foram dividos em 6 grupos distintos (n=5 e foram submetidos à eutanásia após 2, 4, 8, 24, 48 horas e 4 dias. RESULTADOS: Verificou-se redução da camada urotelial em todos animais do grupo B, presença de células inflamatórias e congestão vascular principalmente após 8 horas, entre outros achados. CONCLUSÃO: As alterações histológicas na fase aguda da lesão medular evidenciaram importante comprometimento vesical, sendo essa uma alteração sistêmica de relevância em lesados medulares.Spinal cord trauma is one of the lesions with highest socioeconomical impact. To develop research on spinal cord field it is mandatory to use a reproductible model for inducing lesions. Standardized spinal cord injury (SCI promotes changes not only in the nervous system but also systemic changes. PURPOSE: The aim of this study was to evaluate urinary bladder changes during the acute phase of experimental spinal cord injury. METHODS: Thirty four Wistar male rats were allocated in 2 groups: controll (A and experiment (B. While animals from group B underwent laminectomy at T9-T10 level followed by SCI, group A underwent only

Transplantation of autologous bone marrow stem cells via hepatic artery for the treatment of acute hepatic injury: an experimental study in rabbits

International Nuclear Information System (INIS)

Zhu Yinghe; Han Jinling; Liu Yanping; Gao Jue; Xu Ke; Zhang Xitong; Ding Guomin

2009-01-01

Objective: To evaluate the transplantation of autologous bone marrow stem cells via hepatic artery in treating acute hepatic injury in experimental rabbit models and to clarify the synergistic effect of hepatocyte growth-promoting factor (pHGF) in stem cell transplantation therapy for liver injury. Methods Acute hepatic injury models were established in 15 experimental rabbits by daily subcutaneous injection of CCl 4 olive oil solution with the dose of 0.8 ml/kg for 4 days in succession. The experimental rabbits were randomly and equally divided into three groups: study group A (stem cell transplant, n = 5), study group B (stem cell transplant + pFHG, n = 5), and control group (n = 5). Bone marrow of 5 ml was drawn from the tibia in all rabbits of both study groups, from which bone marrow stem cells were isolated by using density gradient centrifugation, and 5 ml cellular suspension was prepared. Under fluoroscopic guidance, catheterization through the femoral artery was performed and the cellular suspension was infused into the liver via the hepatic artery. Only injection of saline was carried out in the rabbits of control group. For the rabbits in group B, pFHG (2.0 mg/kg) was administered intravenously every other day for 20 days. At 2, 4 and 8 weeks after stem cell transplantation, hepatic function was determined. Eight weeks after the transplantation all the rabbits were sacrificed and the liver specimens were collected and sent for pathological examination. Results After stem cell transplantation, the hepatic function was gradually improved.Eight weeks after the transplantation, the activity of AST, ALT and the content of ALB, TBIL were significantly lower than that before the procedure, while the content of GOLB was markedly increased in all rabbits. In addition, the difference in the above parameters between three groups was statistically significant (P < 0.05). Pathologically, the hepatocyte degeneration and the fiberous hyperplasia in the study groups

Interactions between crush conditions and fire resistance for type B(U) packages less than 500 kg

International Nuclear Information System (INIS)

Huebner, H.W.; Masslowski, J.P.

1983-01-01

In the continuation of the research work by BAM and the Commissariat a l'Energie Atomique (CEA), France, a study was made of the increased risk in regard to low-probability accidents, involving small, type B packages. An evaluation was made of the increased risk when small, type B packages are involved with a low-probability accident - one that involves both crush forces and exposure to a hydrocarbon fire. 3 references, 3 figures

A 51-year-old woman crushed by an elephant trunk.

Science.gov (United States)

Tsung, Ann H; Allen, Brandon R

2015-03-01

Wild and exotic animal attacks are not common in the United States. Animal-related injuries in the United States are usually caused by dog bites, followed by cattle and horse injuries. Exotic animal attacks can occur when the animals are provoked, depressed, or housed improperly by owners. We report the case of a 51-year-old woman who sustained multiple systemic traumatic injuries after she was pinned to a fence by an elephant's trunk. Upon arrival in the emergency department, she was hypothermic with a temperature of 35.1ºC (95.1ºF), hypotensive to 94/60 mm Hg after 5 L crystalloid, tachycardic at 108 beats/min, and intubated with oxygen saturation of 100%. Tranexamic acid was administered in addition to starting a massive transfusion protocol. Injuries included bilateral multiple rib fractures, left abdominal wall degloving injury, right pneumothorax, right hemothorax, left chest wall puncture wound, grade IV splenic laceration, 3 grade III liver lacerations, retroperitoneal hematoma, and degloving injuries to bilateral posterior thighs requiring more than 30 operations. Why should an emergency physician be aware of this? Several factors need to be considered when evaluating animal-related injuries, including type, age, and sex of the animal. Multisystem traumatic injuries should be assumed when a large animal is involved. Prehospital care and transport time are vital to a patient's survival in both urban and rural settings. During the initial resuscitation, administering antibiotics tailored to the specific animal can greatly decrease risk of infection and morbidity. Additionally, tetanus immunoglobulin, tetanus toxoid, and rabies immunoglobulin and vaccine may be needed, unless the victim has been previously vaccinated. Copyright © 2015 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Respiratory mechanics in brain injury: A review

OpenAIRE

Koutsoukou, Antonia; Katsiari, Maria; Orfanos, Stylianos E; Kotanidou, Anastasia; Daganou, Maria; Kyriakopoulou, Magdalini; Koulouris, Nikolaos G; Rovina, Nikoletta

2016-01-01

Several clinical and experimental studies have shown that lung injury occurs shortly after brain damage. The responsible mechanisms involve neurogenic pulmonary edema, inflammation, the harmful action of neurotransmitters, or autonomic system dysfunction. Mechanical ventilation, an essential component of life support in brain-damaged patients (BD), may be an additional traumatic factor to the already injured or susceptible to injury lungs of these patients thus worsening lung injury, in case ...

Effects of sports injury prevention training on the biomechanical risk factors of anterior cruciate ligament injury in high school female basketball players.

Science.gov (United States)

Lim, Bee-Oh; Lee, Yong Seuk; Kim, Jin Goo; An, Keun Ok; Yoo, Jin; Kwon, Young Hoo

2009-09-01

Female athletes have a higher risk of anterior cruciate ligament injury than their male counterparts who play at similar levels in sports involving pivoting and landing. The competitive female basketball players who participated in a sports injury prevention training program would show better muscle strength and flexibility and improved biomechanical properties associated with anterior cruciate ligament injury than during the pretraining period and than posttraining parameters in a control group. Controlled laboratory study. A total of 22 high school female basketball players were recruited and randomly divided into 2 groups (the experimental group and the control group, 11 participants each). The experimental group was instructed in the 6 parts of the sports injury prevention training program and performed it during the first 20 minutes of team practice for the next 8 weeks, while the control group performed their regular training program. Both groups were tested with a rebound-jump task before and after the 8-week period. A total of 21 reflective markers were placed in preassigned positions. In this controlled laboratory study, a 2-way analysis of variance (2 x 2) experimental design was used for the statistical analysis (P training effects on all strength parameters (P = .004 to .043) and on knee flexion, which reflects increased flexibility (P = .022). The experimental group showed higher knee flexion angles (P = .024), greater interknee distances (P = .004), lower hamstring-quadriceps ratios (P = .023), and lower maximum knee extension torques (P = .043) after training. In the control group, no statistical differences were observed between pretraining and posttraining findings (P = .084 to .873). At pretraining, no significant differences were observed between the 2 groups for any parameter (P = .067 to .784). However, a comparison of the 2 groups after training revealed that the experimental group had significantly higher knee flexion angles (P = .023

Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model

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C. Probst

2012-01-01

Full Text Available Objective. Despite broad research in neurotrauma and shock, little is known on systemic inflammatory effects of the clinically most relevant combined polytrauma. Experimental investigation in an animal model may provide relevant insight for therapeutic strategies. We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation. Methods. 45 male C57BL/6J mice (mean weight 27 g were anesthetized with ketamine/xylazine. Animals were subjected to a weight drop closed traumatic brain injury (WD-TBI, a femoral fracture and hemorrhagic shock (FX-SH. Animals were subdivided into WD-TBI, FX-SH and combined trauma (CO-TX groups. Subjects were sacrificed at 96 h. Blood was analysed for cytokines and by flow cytometry for lymphocyte populations. Results. Mortality was 8%, 13% and 47% for FX-SH, WD-TBI and CO-TX groups (P<0.05. TNFα (11/13/139 for FX-SH/WD-TBI/CO-TX; P<0.05, CCL2 (78/96/227; P<0.05 and IL-6 (16/48/281; P=0.05 showed significant increases in the CO-TX group. Lymphocyte populations results for FX-SH, WD-TBI and CO-TX were: CD-4 (31/21/22; P= n.s., CD-8 (7/28/34, P<0.05, CD-4-CD-8 (11/12/18; P= n.s., CD-56 (36/7/8; P<0.05. Conclusion. This study shows that a combination of closed TBI and femur-fracture/ shock results in an increase of the humoral inflammation. More attention to combined injury models in inflammation research is indicated.