WorldWideScience

Sample records for experimental analysis links

  1. Experimental Performance Analysis of Wireless Links for Healthcare ...

    African Journals Online (AJOL)

    Wireless networking is currently being deployed for various applications. However, the application of wireless networking in healthcare remains a challenge mainly because of security and reliability concerns. This paper presents experimental results of performance analysis of a wireless network for healthcare application ...

  2. Theoretical and experimental analysis of inverter fed induction motor system under DC link capacitor failure

    Directory of Open Access Journals (Sweden)

    Hadeed A. Sher

    2017-04-01

    Full Text Available In this paper theoretical and experimental analysis of an AC–DC–AC inverter under DC link capacitor failure is presented. The failure study conducted for this paper is the open circuit of the DC link capacitor. The presented analysis incorporates the results for both single and three phase AC input. It has been observed that the higher ripple frequency provides better ride through capability for this fault. Furthermore, the effects of this fault on electrical characteristics of AC–DC–AC inverter and mechanical properties of the induction motor are also presented. Moreover, the effect of pulsating torque as a result of an open circuited DC link capacitor is also taken into consideration. Theoretical analysis is supported by computer aided simulation as well as with a real time experimental prototype.

  3. A unified approach to linking experimental, statistical and computational analysis of spike train data.

    Directory of Open Access Journals (Sweden)

    Liang Meng

    Full Text Available A fundamental issue in neuroscience is how to identify the multiple biophysical mechanisms through which neurons generate observed patterns of spiking activity. In previous work, we proposed a method for linking observed patterns of spiking activity to specific biophysical mechanisms based on a state space modeling framework and a sequential Monte Carlo, or particle filter, estimation algorithm. We have shown, in simulation, that this approach is able to identify a space of simple biophysical models that were consistent with observed spiking data (and included the model that generated the data, but have yet to demonstrate the application of the method to identify realistic currents from real spike train data. Here, we apply the particle filter to spiking data recorded from rat layer V cortical neurons, and correctly identify the dynamics of an slow, intrinsic current. The underlying intrinsic current is successfully identified in four distinct neurons, even though the cells exhibit two distinct classes of spiking activity: regular spiking and bursting. This approach--linking statistical, computational, and experimental neuroscience--provides an effective technique to constrain detailed biophysical models to specific mechanisms consistent with observed spike train data.

  4. Experimental modal analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    This technical report concerns the basic theory and principles for experimental modal analysis. The sections within the report are: Output-only modal analysis software, general digital analysis, basics of structural dynamics and modal analysis and system identification. (au)

  5. An Experimental Study of FSO Link Performance in Desert Environment

    KAUST Repository

    Esmail, Maged; Fathallah, Habib; Alouini, Mohamed-Slim

    2016-01-01

    Free space optical (FSO) communication systems are affected by dust particles suspended in the atmosphere in arid and semi-arid regions. The presence of these particles in the air severely affects the optical link, reduces its availability and causes service outage. In the literature, the effect of dust on the microwave signals has been widely investigated. However, for FSO communication systems that exploit shorter wavelengths, information and research is still very limited yet almost inexistent. Therefore, in this paper, we investigate the performance of FSO links under dust storms. We designed a chamber to emulate this specific environment and carry out measurements. From the experimental investigations, we derive and propose an empirical model for the signal attenuation as a function of the visibility range. The results show acceptable performance for FSO links, under moderate and light dust, with potential reach distance of hundreds of meters to few kilometers. Furthermore, a comparison analysis shows that the dust induces 7 times higher attenuation than fog.

  6. An Experimental Study of FSO Link Performance in Desert Environment

    KAUST Repository

    Esmail, Maged

    2016-06-29

    Free space optical (FSO) communication systems are affected by dust particles suspended in the atmosphere in arid and semi-arid regions. The presence of these particles in the air severely affects the optical link, reduces its availability and causes service outage. In the literature, the effect of dust on the microwave signals has been widely investigated. However, for FSO communication systems that exploit shorter wavelengths, information and research is still very limited yet almost inexistent. Therefore, in this paper, we investigate the performance of FSO links under dust storms. We designed a chamber to emulate this specific environment and carry out measurements. From the experimental investigations, we derive and propose an empirical model for the signal attenuation as a function of the visibility range. The results show acceptable performance for FSO links, under moderate and light dust, with potential reach distance of hundreds of meters to few kilometers. Furthermore, a comparison analysis shows that the dust induces 7 times higher attenuation than fog.

  7. Channel CAT: A Tactical Link Analysis Tool

    Science.gov (United States)

    1997-09-01

    NAVAL POSTGRADUATE SCHOOL Monterey, California THESIS CHANNEL CAT : A TACTICAL LINK ANALYSIS TOOL by Michael Glenn Coleman September 1997 Thesis...REPORT TYPE AND DATES COVERED September 1997 Master’s Thesis 4. TITLE AND SUBTITLE CHANNEL CAT : A TACTICAL LINK ANALYSIS TOOL 5. FUNDING NUMBERS 6...tool, the Channel Capacity Analysis Tool (Channel CAT ), designed to provide an automated tool for the anlysis of design decisions in developing client

  8. Wallops' Low Elevation Link Analysis for the Constellation Launch/Ascent Links

    Science.gov (United States)

    Cheung, Kar-Ming; Ho, Christian; Kantak, Anil; Lee, Charles; Tye, Robert; Richards, Edger; Sham, Catherine; Schlesinger, Adam; Barritt, Brian

    2011-01-01

    Prior to the redirection of the Constellation Program, the Wallops 11.3-meter ground station was tasked to support the Orion's Dissimilar Voice (DV) link and the Ares's Development Flight Instrument (DFI) link. Detailed analysis of the launch trajectories indicates that during the launch and ascent operation, the critical events of Orion-Ares main engine cut off (MECO) and Separation occur at low elevation angle. We worked with engineers from both Wallops Flight Facility (WFF) and Johnson Space Center (JSC) to perform an intensive measurement and link analysis campaign on the DV and DFI links. The main results were as follows: (1) The DV links have more than 3 dB margin at MECO and Separation. (2) The DFI links have 0 dB margin at Separation during certain weather condition in summer season. (3) Tropospheric scintillation loss is the major impairment at low elevation angle. (4) The current scintillation models in the Recommendation ITU-R P.618 (Propagation data and prediction methods required for the design of Earth-space telecommunication systems), which are based on limited experimental and theoretical work, exhibit idiosyncratic behaviors. We developed an improved model based on the measurements of recent Shuttle mission launch and ascent links and the ITU propagation data. (5) Due to the attitude uncertainty of the Orion-Ares stack, the high dynamics of the launch and ascent trajectory, and the irregularity of the Orion and Ares antenna patterns, we employed new link analysis approach to model the spacecraft antenna gain. In this paper we discuss the details of the aforementioned results.

  9. Analysis of DCA experimental data

    International Nuclear Information System (INIS)

    Min, B. J.; Kim, S. Y.; Ryu, S. J.; Seok, H. C.

    2000-01-01

    The lattice characteristics of DCA are calculated with WIMS-ATR code to validate WIMS-AECL code for the lattice analysis of CANDU core by using experimental data of DCA at JNC. Analytical studies of some critical experiments had been performed to analyze the effects of fuel composition. Different items of reactor physics such as local power peaking factor (LPF), effective multiplication factor (Keff) and coolant void reactivity were calculated for two coolant void fractions (0% and 100%). LPFs calculated by WIMS-ATR code are in close agreement with the experimental results. LPFs calculated by WIMS-AECL code with WINFRITH and ENDF/B-V libraries have similar values for both libraries but the differences between experimental data and calculated results by WIMS-AECL code are larger than those of WIMS-ATR code. The maximum difference between the values calculated by WIMS-ATR and experimental values of LPFs are within 1.3%. The coupled code systems WIMS-ATR and CITATION used in this analysis predict Keff within 1% ΔK and coolant void reactivity within 4 % ΔK/K in all cases. The coolant void reactivity of uranium fuel is found to be positive. To validate WIMS-AECL code, the core characteristics of DCA shall be calculated by WIMS-AECL and CITATION codes in the future

  10. TFTR Experimental Data Analysis Collaboration

    International Nuclear Information System (INIS)

    Callen, J.D.

    1993-01-01

    The research performed under the second year of this three-year grant has concentrated on a few key TFTR experimental data analysis issues: MHD mode identification and effects on supershots; identification of new MHD modes; MHD mode theory-experiment comparisons; local electron heat transport inferred from impurity-induced cool pulses; and some other topics. Progress in these areas and activities undertaken in conjunction with this grant are summarized briefly in this report

  11. Free Space Optics – Monitoring Setup for Experimental Link

    Directory of Open Access Journals (Sweden)

    Ján Tóth

    2015-12-01

    Full Text Available This paper deals with advanced Free Space Optics communication technology. Two FSO nodes are needed in order to make a connection. Laser diodes are used as light sources. Simple OOK modulation is involved in this technology. FSO system offers multiple advantages indeed. However, a direct visibility is required in order to set up a communication link. This fact yields perhaps the most significant weakness of this technology. Obviously, there is no a chance to fight the weather phenomena like fog, heavy rain, dust and many other particles which are naturally present in the atmosphere. That’s why there is a key task to find a suitable solution to keep FSO link working with high reliability and availability. It turns out that it’s necessary to have knowledge about weather situation when FSO link operates (liquid water content - LWC, geographical location, particle size distribution, average particle diameter, temperature, humidity, wind conditions, pressure and many other variable weather parameters. It’s obvious that having most of mentioned parameter’s values stored in database (implicitly in charts would be really beneficial. This paper presents some of mentioned indicators continuously gathered from several sensors located close to one of FSO nodes.

  12. Historical Links between Latin American Psychology and Pedagogy in Experimentation

    Science.gov (United States)

    Arias, Walter L.

    2014-01-01

    This work sets out historical information about the development of Latin American psychology over the base of education. It reviews the contribution from education to Latin American psychology, and especially, the creation of experimental psychology laboratories in schools and educational and psychopedagogical institutions, where experimental…

  13. Linking advanced fracture models to structural analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chiesa, Matteo

    2001-07-01

    Shell structures with defects occur in many situations. The defects are usually introduced during the welding process necessary for joining different parts of the structure. Higher utilization of structural materials leads to a need for accurate numerical tools for reliable prediction of structural response. The direct discretization of the cracked shell structure with solid finite elements in order to perform an integrity assessment of the structure in question leads to large size problems, and makes such analysis infeasible in structural application. In this study a link between local material models and structural analysis is outlined. An ''ad hoc'' element formulation is used in order to connect complex material models to the finite element framework used for structural analysis. An improved elasto-plastic line spring finite element formulation, used in order to take cracks into account, is linked to shell elements which are further linked to beam elements. In this way one obtain a global model of the shell structure that also accounts for local flexibilities and fractures due to defects. An important advantage with such an approach is a direct fracture mechanics assessment e.g. via computed J-integral or CTOD. A recent development in this approach is the notion of two-parameter fracture assessment. This means that the crack tip stress tri-axiality (constraint) is employed in determining the corresponding fracture toughness, giving a much more realistic capacity of cracked structures. The present thesis is organized in six research articles and an introductory chapter that reviews important background literature related to this work. Paper I and II address the performance of shell and line spring finite elements as a cost effective tool for performing the numerical calculation needed to perform a fracture assessment. In Paper II a failure assessment, based on the testing of a constraint-corrected fracture mechanics specimen under tension, is

  14. Feasibility Study and Experimental Verification of Simplified Fiber-Supported 60-GHz Picocell Mobile Backhaul Links

    DEFF Research Database (Denmark)

    Lebedev, Alexander; Pang, Xiaodan; Vegas Olmos, Juan José

    2013-01-01

    We propose and experimentally demonstrate a fiber-wireless transmission system for optimized delivery of 60-GHz radio frequency (RF) signals through picocell mobile backhaul connections. We identify advantages of 60-GHz links for utilization in short-range mobile backhaul through feasibility...... the wireless transmission distance from 4 m to a few hundred meters has been taken into account in the setup design, and the techniques to extend the wireless distance are analyzed....... analysis and comparison with an alternative E-band (60–90 GHz) technology. The 60-GHz fiber-wireless-fiber setup is then introduced: two spans of up to 20 km of optical fiber are deployed and bridged by up to 4 m of wireless distance. The 60-GHz radio-over-fiber technology is utilized in the first span...

  15. Optimal trajectories for flexible-link manipulator slewing using recursive quadratic programming: Experimental verification

    International Nuclear Information System (INIS)

    Parker, G.G.; Eisler, G.R.; Feddema, J.T.

    1994-01-01

    Procedures for trajectory planning and control of flexible link robots are becoming increasingly important to satisfy performance requirements of hazardous waste removal efforts. It has been shown that utilizing link flexibility in designing open loop joint commands can result in improved performance as opposed to damping vibration throughout a trajectory. The efficient use of link compliance is exploited in this work. Specifically, experimental verification of minimum time, straight line tracking using a two-link planar flexible robot is presented. A numerical optimization process, using an experimentally verified modal model, is used for obtaining minimum time joint torque and angle histories. The optimal joint states are used as commands to the proportional-derivative servo actuated joints. These commands are precompensated for the nonnegligible joint servo actuator dynamics. Using the precompensated joint commands, the optimal joint angles are tracked with such fidelity that the tip tracking error is less than 2.5 cm

  16. Wallops Low Elevation Link Analysis for the Constellation Launch/Ascent Links

    Science.gov (United States)

    Cheung, Keith; Ho, C.; Kantak, A.; Lee, C.; Tye, R.; Richards, E.; Sham, C.; Schlesinger, A.; Barritt, B.

    2011-01-01

    To execute the President's Vision for Space Exploration, the Constellation Program (CxP) was formed to build the next generation spacecraft Orion and launch vehicles Ares, to transport human and cargo to International Space Station (ISS), moon, and Mars. This paper focuses on the detailed link analysis for Orion/Ares s launch and ascent links with Wallops 11.3m antenna (1) Orion's Dissimilar Voice link: 10.24 Kbps, 2-way (2) Ares Developmental Flight Instrument link, 20 Mbps, downlink. Three launch trajectories are considered: TD7-E, F (Feb), and G (Aug). In certain launch scenarios, the critical events of main engine cutoff (MECO) and Separation occur during the low elevation regime of WFF s downrange -- less than 5 degree elevation angle. The goal of the study is to access if there is enough link margins for WFF to track the DV and DFI links.

  17. Analysis Links Zoning Policies and Disparities

    Science.gov (United States)

    Shah, Nirvi

    2012-01-01

    Location, location, location. This mantra of real estate agents and their clients alike is now the target of a new report from the Brookings Institution linking housing prices and zoning practices to effectively depriving low-income students of high-quality schools. Using test scores from schools in the 100 largest metropolitan areas in the…

  18. Experimental Evaluation of TCP-Based DTN for Cislunar Communications in Presence of Long Link Disruption

    Directory of Open Access Journals (Sweden)

    Zhang Zhensheng

    2011-01-01

    Full Text Available Delay/disruption tolerant networking (DTN technology is considered a new solution to highly stressed communications in space environments. To date, little work has been done in evaluating the effectiveness and performance of the available DTN protocols when they are applied to an interplanetary Internet, especially in presence of a long link disruption. In this paper, we present an experimental investigation of the DTN architecture with a Bundle Protocol (BP running over TCP-based convergence layer (TCPCL protocol in a simulated cislunar communication environment characterized by a long link disruption. The intent of this work is to investigate the effectiveness of the TCPCL-based DTN protocol in coping with long link disruptions, through realistic file transfer experiments using a PC-based test-bed. The experiment results show that the DTN protocol is effective in handling a long link disruption experienced in data transmission accompanied by a cislunar link delay and a high BER. The performance of the DTN is most adversely affected by link disruption time in comparison to the effect of link delay and BER. For the transmissions with a very long link disruption of hours, the variations in goodput are nominal with respect to the change in cislunar link delay.

  19. Channel CAT: A Tactical Link Analysis Tool

    National Research Council Canada - National Science Library

    Coleman, Michael

    1997-01-01

    .... This thesis produced an analysis tool, the Channel Capacity Analysis Tool (Channel CAT), designed to provide an automated tool for the analysis of design decisions in developing client-server software...

  20. EXPERIMENTAL MEASUREMENT, ANALYSIS AND MODELLING ...

    African Journals Online (AJOL)

    30 juin 2010 ... We obtain a good agreement between the resolution of the nonlinear equation of heat and the results obtained by the experimentation. . Keywords: Emissivity, Température, optimal Linearisation, finite elements. 1. ..... basse température, Rapport de Stage de D.E.A, Université Paris 12 – Val de Marne.

  1. Experimental analysis of armouring process

    Science.gov (United States)

    Lamberti, Alberto; Paris, Ennio

    Preliminary results from an experimental investigation on armouring processes are presented. Particularly, the process of development and formation of the armour layer under different steady flow conditions has been analyzed in terms of grain size variations and sediment transport rate associated to each size fraction.

  2. Susceptibility to experimental biliary atresia linked to different hepatic gene expression profiles in two mouse strains.

    Science.gov (United States)

    Leonhardt, Johannes; Kuebler, Joachim F; Turowski, Carmen; Tschernig, Thomas; Geffers, Robert; Petersen, Claus

    2010-02-01

    To compare hepatic gene expression during the development of experimental biliary atresia (BA) in two different mouse strains. Balb/c mice and C57Black/6 (Black/6) mice were infected with rhesus rotavirus (RRV) postpartum, clinical signs of BA and survival were noted. Liver sections were assessed for cluster of differentiation antigen (CD) 3, CD4 and CD8 expression, and the hepatic virus load was determined. Second, mice of both strains were sacrificed three days after infection. Isolated hepatic RNA was subjected to gene expression analysis using Affymetrix Gene Chip MOE 430 2.0. The incidence of BA was significantly lower in Black/6 mice compared to Balb/c mice (13.5% vs. 67%, P < 0.05). The mean virus titers were higher in mice with BA compared to mice without BA. Different gene profiles three days after virus infection were noted, with differential expression of 201 genes, including those regulating apoptosis, nucleic acid binding, transport function and particularly the immune response (chemokine C-C motif ligand 2, toll-like receptor 3, CD antigen 14, chemokine (C-X-C motif) ligands 10 and 11). This correlated with a significant increase of CD4 positive cells only in Balb/c mice with BA compared to healthy mice (13.5 vs. 5.0; P < 0.05). Black/6 mice did not exhibit any significant increase of CD3 or CD4 leukocytes despite cholestasis. The different susceptibility to experimental BA was associated with an increase of CD4 T-cells in the liver of Balb/c mice, which is linked to different gene profiles at the onset of bile duct obstruction.

  3. Experimental demonstration of optical data links using a hybrid CAP/QAM modulation scheme.

    Science.gov (United States)

    Wei, J L; Ingham, J D; Cheng, Q; Cunningham, D G; Penty, R V; White, I H

    2014-03-15

    The first known experimental demonstrations of a 10  Gb/s hybrid CAP-2/QAM-2 and a 20  Gb/s hybrid CAP-4/QAM-4 transmitter/receiver-based optical data link are performed. Successful transmission over 4.3 km of standard single-mode fiber (SMF) is achieved, with a link power penalty ∼0.4  dBo for CAP-2/QAM-2 and ∼1.5  dBo for CAP-4/QAM-4 at BER=10(-9).

  4. Linking Safety Analysis to Safety Requirements

    DEFF Research Database (Denmark)

    Hansen, Kirsten Mark

    Software for safety critical systems must deal with the hazards identified by safety analysistechniques: Fault trees, event trees,and cause consequence diagrams can be interpreted as safety requirements and used in the design activity. We propose that the safety analysis and the system design use...

  5. Instrumental neutron activation analysis, a valuable link in chemical metrology

    International Nuclear Information System (INIS)

    Zeisler, R.; Lindstrom, R.M.; Greenberg, R.R.

    2002-01-01

    Instrumental neutron activation analysis (INAA) is sufficiently versatile to establish a direct link to the amount of substance determined. The inherent quality parameters of INAA, such as being virtually free of blank, having fully accountable effects of matrix and physical form, and operating over a huge range of amounts, allows the comparison of a mole (or its fraction) of a pure element with the amount of substance in the sample analyzed with the same direct relationship as a beam balance provides. Indeed, varieties of this approach are in common use in INAA in the comparator methods of quantitation. To eliminate possible perturbations of the traceability chain as they may occur in common INAA practice, experimental measurements have been set up that only involve the fraction of a mole of the element(s) of interest in form of the pure element, compound or certified standard and the unknown sample. This principle has been used in INAA measurements for certification value assignment of high temperature alloy SRMs. To further demonstrate the performance parameters of INAA, we selected the determination of chromium in SRM 1152a Stainless Steel by direct non-destructive comparison with the pure metal in form of crystalline chromium. The measurements were validated with weighed aliquots of SRM 3112a dried on filter paper pellets. The experimental results do not show deviations beyond the uncertainties of the SRMs (≤ 0.2 % relative), and the assessment of the uncertainty budget indicates that expanded uncertainties of ≤ 0.3 % are achievable. The measurements demonstrate that INAA can meet the CCQM definition of a primary ratio method of analysis

  6. R dump converter without DC link capacitor for an 8/6 SRM: experimental investigation.

    Science.gov (United States)

    Kavitha, Pasumalaithevan; Umamaheswari, Bhaskaran

    2015-01-01

    The objective of this paper is to investigate the performance of 8/6 switched reluctance motor (SRM) when excited with sinusoidal voltage. The conventional R dump converter provides DC excitation with the help of capacitor. In this paper the converter used is the modified R dump converter without DC link capacitor providing AC or sinusoidal excitation. Torque ripple and speed ripple are investigated based on hysteresis current control. Constant and sinusoidal current references are considered for comparison in both DC and AC excitation. Extensive theoretical and experimental investigations are made to bring out the merits and demerits of AC versus DC excitation. It is shown that the constructionally simple SRM can be favorably controlled with simple R dump converter with direct AC excitation without need for DC link capacitor. A 4-phase 8/6 0.5 kW SRM is used for experimentation.

  7. Experimental design and quantitative analysis of microbial community multiomics.

    Science.gov (United States)

    Mallick, Himel; Ma, Siyuan; Franzosa, Eric A; Vatanen, Tommi; Morgan, Xochitl C; Huttenhower, Curtis

    2017-11-30

    Studies of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular methods as well as culture-based methods exist for population-scale microbiome profiles. To link the resulting host and microbial data types to human health, several experimental design considerations, data analysis challenges, and statistical epidemiological approaches must be addressed. Here, we survey current best practices for experimental design in microbiome molecular epidemiology, including technologies for generating, analyzing, and integrating microbiome multiomics data. We highlight studies that have identified molecular bioactives that influence human health, and we suggest steps for scaling translational microbiome research to high-throughput target discovery across large populations.

  8. Data Analysis in Experimental Biomedical Research

    DEFF Research Database (Denmark)

    Markovich, Dmitriy

    This thesis covers two non-related topics in experimental biomedical research: data analysis in thrombin generation experiments (collaboration with Novo Nordisk A/S), and analysis of images and physiological signals in the context of neurovascular signalling and blood flow regulation in the brain...... to critically assess and compare obtained results. We reverse engineered the data analysis performed by CAT, a de facto standard assay in the field. This revealed a number of possibilities to improve its methods of data analysis. We found that experimental calibration data is described well with textbook...

  9. Etude théorique et expérimentale de la liaison de deux puits par fracturation hydraulique Theoretical and Experimental Analysis of the Linking of Two Wells by Hydraulic Fracturing

    Directory of Open Access Journals (Sweden)

    Bouteca M.

    2006-11-01

    Full Text Available La nécessité de réaliser, dans une couche mince et située à plus de 1000 m de profondeur, une communication hydraulique ou pneumatique entre deux sondages verticaux, a conduit à l'étude d'une méthode basée sur la fracturation hydraulique des puits à relier. Une telle approche suppose que l'on connaisse ou que l'on contrôle la direction des fractures développées. Les techniques actuelles ne permettant pas d'apprécier la direction de fracture avec une précision suffisante, la méthode proposée vise à influencer favorablement cette direction. Elle est basée sur une modification des contraintes effectives en place par une injection préalable de fluide dans les puits à relier. Les résultats obtenus au moyen de calculs analytiques et numériques à deux dimensions sont présentés, ainsi que les expériences réalisées sur un modèle physique en laboratoire. In a thin layer and at a depth of more than 1000 meters, the need to create a hydraulic or pneumatic communication between two vertical boreholes led to research on a method based on hydraulic fracturing in the wells to be linked. Such an approach supposes that the direction of the fractures thus created must be known or controlled. Current techniques cannot be used to assess fracture direction with sufficient accuracy. The method proposed here aims to have a favorable influence on this direction. It is based on making a change in the effective stresses in situ by the prior injection of fluid into the wells to be linked. The results obtained by two-dimensional analytical and digital computing are described together with the experiments performed on a physical model in the laboratory.

  10. Linking Ayurveda and Western medicine by integrative analysis

    Directory of Open Access Journals (Sweden)

    Fazlin Mohd Fauzi

    2013-01-01

    Full Text Available In this article, we discuss our recent work in elucidating the mode-of-action of compounds used in traditional medicine including Ayurvedic medicine. Using computational (′in silico′ approach, we predict potential targets for Ayurvedic anti-cancer compounds, obtained from the Indian Plant Anticancer Database given its chemical structure. In our analysis, we observed that: (i the targets predicted can be connected to cancer pathogenesis i.e. steroid-5-alpha reductase 1 and 2 and estrogen receptor-β, and (ii predominantly hormone-dependent cancer targets were predicted for the anti-cancer compounds. Through the use of our in silico target prediction, we conclude that understanding how traditional medicine such as Ayurveda work through linking with the ′western′ understanding of chemistry and protein targets can be a fruitful avenue in addition to bridging the gap between the two different schools of thinking. Given that compounds used in Ayurveda have been tested and used for thousands of years (although not in the same approach as Western medicine, they can potentially be developed into potential new drugs. Hence, to further advance the case of Ayurvedic medicine, we put forward some suggestions namely: (a employing and integrating novel analytical methods given the advancements of ′omics′ and (b sharing experimental data and clinical results on studies done on Ayurvedic compounds in an easy and accessible way.

  11. Linking Ayurveda and Western medicine by integrative analysis.

    Science.gov (United States)

    Fauzi, Fazlin Mohd; Koutsoukas, Alexios; Lowe, Robert; Joshi, Kalpana; Fan, Tai-Ping; Glen, Robert C; Bender, Andreas

    2013-04-01

    In this article, we discuss our recent work in elucidating the mode-of-action of compounds used in traditional medicine including Ayurvedic medicine. Using computational ('in silico') approach, we predict potential targets for Ayurvedic anti-cancer compounds, obtained from the Indian Plant Anticancer Database given its chemical structure. In our analysis, we observed that: (i) the targets predicted can be connected to cancer pathogenesis i.e. steroid-5-alpha reductase 1 and 2 and estrogen receptor-β, and (ii) predominantly hormone-dependent cancer targets were predicted for the anti-cancer compounds. Through the use of our in silico target prediction, we conclude that understanding how traditional medicine such as Ayurveda work through linking with the 'western' understanding of chemistry and protein targets can be a fruitful avenue in addition to bridging the gap between the two different schools of thinking. Given that compounds used in Ayurveda have been tested and used for thousands of years (although not in the same approach as Western medicine), they can potentially be developed into potential new drugs. Hence, to further advance the case of Ayurvedic medicine, we put forward some suggestions namely: (a) employing and integrating novel analytical methods given the advancements of 'omics' and (b) sharing experimental data and clinical results on studies done on Ayurvedic compounds in an easy and accessible way.

  12. Feasibility analysis of WDM links for radar applications

    Directory of Open Access Journals (Sweden)

    D. Meena

    2015-03-01

    Full Text Available Active phased array antennas enhances the performance of modern radars by using multiple low power transmit/receive modules in place of a high power transmitter in conventional radars. Fully distributed phased array radars demand the distribution of various signals in radio frequency (RF and digital domain for real time operation. This is normally achieved through complex and bulky coaxial distribution networks. In this work, we intend to tap the inherent advantages of fiber links with wavelength division multiplexed (WDM technology and a feasibility study to adapt these links for radar applications is carried out. This is done by analysing various parameters like amplitude, delay, frequency and phase variation response of various radar waveforms over WDM links. This also includes performance evaluation of non-linear frequency modulation (NLFM signals, known for better signal to noise ratio (SNR to specific side lobe levels. NLFM waveforms are further analysed using pulse compression (PC technique. Link evaluation is also carried out using a standard simulation environment and is then experimentally verified with other waveforms like RF continuous wave (CW, pulsed RF and digital signals. Synchronization signals are generated from this variable duty cycle digital signals during real time radar operation. During evaluation of digital signals, variable transient effects for different duty cycles are observed from an amplifier configuration. A suppression method is proposed to eliminate this transient effects. Further, the link delay response is investigated using different lengths of fiber spools. It can be inferred from the experimental results that WDM links are capable of handling various signals significant to radar applications.

  13. Experimental Evaluation of Impairments in Unrepeatered DP-16QAM Link with Distributed Raman Amplification

    Directory of Open Access Journals (Sweden)

    Xiaodan Pang

    2017-03-01

    Full Text Available The transmission impairments of a Raman amplified link using dual-polarization 16-quadrature amplitude modulation (DP-16QAM are experimentally characterized. The impact of amplitude and phase noise on the signal due to relative intensity noise (RIN transfer from the pump are compared for two pumping configurations: first-order backward pumping and bi-directional pumping. Experimental results indicate that with increased Raman backward pump power, though the optical signal-to-noise ratio (OSNR is increased, so is the pump-induced amplitude and phase noise. The transmission performance is firstly improved by the enhanced OSNR at a low pump power until an optimum point is reached, and then the impairments due to pump-induced noise start to dominate. However, the introduction of a low pump power in the forward direction can further improve the system’s performance.

  14. Unsupervised action classification using space-time link analysis

    DEFF Research Database (Denmark)

    Liu, Haowei; Feris, Rogerio; Krüger, Volker

    2010-01-01

    In this paper we address the problem of unsupervised discovery of action classes in video data. Different from all existing methods thus far proposed for this task, we present a space-time link analysis approach which matches the performance of traditional unsupervised action categorization metho...

  15. Experimental data base for containment thermalhydraulic analysis

    International Nuclear Information System (INIS)

    Cheng, X.; Bazin, P.; Cornet, P.; Hittner, D.; Jackson, J.D.; Lopez Jimenez, J.; Naviglio, A.; Oriolo, F.; Petzold, H.

    2001-01-01

    This paper describes the joint research project DABASCO which is supported by the European Community under a cost-shared contract and participated by nine European institutions. The main objective of the project is to provide a generic experimental data base for the development of physical models and correlations for containment thermalhydraulic analysis. The project consists of seven separate-effects experimental programs which deal with new innovative conceptual features, e.g. passive decay heat removal and spray systems. The results of the various stages of the test programs will be assessed by industrial partners in relation to their applicability to reactor conditions

  16. Network worlds : from link analysis to virtual places.

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, C. (Cliff)

    2002-01-01

    Significant progress is being made in knowledge systems through recent advances in the science of very large networks. Attention is now turning in many quarters to the potential impact on counter-terrorism methods. After reviewing some of these advances, we will discuss the difference between such 'network analytic' approaches, which focus on large, homogeneous graph strucures, and what we are calling 'link analytic' approaches, which focus on somewhat smaller graphs with heterogeneous link types. We use this venue to begin the process of rigorously defining link analysis methods, especially the concept of chaining of views of multidimensional databases. We conclude with some speculation on potential connections to virtual world architectures.

  17. Input Harmonic Analysis on the Slim DC-Link Drive Using Harmonic State Space Model

    DEFF Research Database (Denmark)

    Yang, Feng; Kwon, Jun Bum; Wang, Xiongfei

    2017-01-01

    The harmonic performance of the slim dc-link adjustable speed drives has shown good performance in some studies but poor in some others. The contradiction indicates that a feasible theoretical analysis is still lacking to characterize the harmonic distortion for the slim dc-link drive. Considerin...... results of the slim dc-link drive, loaded up to 2.0 kW, are presented to validate the theoretical analysis....... variation according to the switching instant, the harmonics at the steady-state condition, as well as the coupling between the multiple harmonic impedances. By using this model, the impaction on the harmonics performance by the film capacitor and the grid inductance is derived. Simulation and experimental...

  18. Experimental study of mixed convection flow through a horizontal orifice or vent linking two compartments

    International Nuclear Information System (INIS)

    Varrall, Kevin

    2016-01-01

    To answer building issues and fire safety challenges, this thesis deals with the mixed convection flow through a horizontal orifice or vent linking two compartments. The aim is to improve the understanding and the modeling of the exchange of gas through the opening. A small scale experimental study and a theoretical approach are proposed. The study focuses first on the influence of the geometrical ratio L/D of the opening on the flow rate at the vent for free convection regime. Non-intrusive measurements, via the tracking of the interface between two non miscible liquids in an isothermal approach, and thanks to the SPIV in a thermal approach, permit to describe the bidirectional exchange process and to consolidate existing correlations. Experiments for mixed convection regime aim to study the impact of mechanical ventilation (in blowing and extracting modes) on the exchanged flow rates. The comparison between existing correlations and experimental data shows large differences. A modification of the correlation of Cooper is proposed. A theoretical approach from the simplified Navier Stokes equations and with the Boussinesq approximation permits to discuss the construction of existing correlations. From this theory, a more accurate model than those available in the literature is proposed thanks to an adjustment of discharge coefficients from experimental data. (author)

  19. Experimental Characterization of LTE Wireless Links in High-Speed Trains

    Directory of Open Access Journals (Sweden)

    Tomás Domínguez-Bolaño

    2017-01-01

    Full Text Available Multimedia and data-based services experienced a nonstopping growth over the last few years. People are continuously on the move using devices to access multimedia contents or other data-based services. Due to this, railway companies are showing a great interest in deploying broadband mobile wireless networks in high-speed-trains with the aim of supporting both passenger services provisioning as well as automatic train control and signaling. Nowadays, the most widely used technology for communications between trains and the railway infrastructure is GSM for Railways (GSM-R; however, it has limited capabilities to support such advanced services. Due to its success in the mass market, Long Term Evolution (LTE seems to be the best candidate to substitute GSM-R. In this paper, we experimentally characterize the downlink between an LTE Evolved NodeB (eNodeB and a high-speed train in a commercial high-speed line. We consider two links: the one between the eNodeB and the antennas placed outdoors on the train roof, and the direct link between the eNodeB and a receiver inside the train. Such a characterization consists in assessing the path loss, the Signal to Noise Ratio, the K-Factor, the Power Delay Profile, the delay spread, and the Doppler Power Spectral Density.

  20. Induction of corneal collagen cross-linking in experimental corneal alkali burns in rabbits

    Directory of Open Access Journals (Sweden)

    Marcello Colombo-Barboza

    2014-10-01

    Full Text Available Objective: To evaluate the effect of riboflavin-ultraviolet-A-induced cross-linking (CXL following corneal alkali burns in rabbits. Methods: The right corneas and limbi of ten rabbits were burned using a 1N solution of NaOH and the animals were then divided into two groups: a control group submitted to clinical treatment alone and an experimental group that was treated 1 h after injury with CXL, followed by the same clinical treatment as administered to the controls. Clinical parameters were evaluated post-injury at 1, 7, 15, and 30 days by two independent observers. Following this evaluation, the corneas were excised and examined histologically. Results: There were no statistically significant differences in clinical parameters, such as hyperemia, corneal edema, ciliary injection, limbal ischemia, secretion, corneal neovascularization, symblepharon, or blepharospasm, at any of the time-points evaluated. However, the size of the epithelial defect was significantly smaller in the CXL group (p<0.05 (day 15: p=0.008 and day 30: p=0.008 and the extent of the corneal injury (opacity lesion was also smaller (day 30: p=0.021. Histopathology showed the presence of collagen bridges linking the collagen fibers in only the CXL group. Conclusions: These results suggest that the use of CXL may improve the prognosis of acute corneal alkali burns.

  1. Protein functional links in Trypanosoma brucei, identified by gene fusion analysis

    Directory of Open Access Journals (Sweden)

    Trimpalis Philip

    2011-07-01

    Full Text Available Abstract Background Domain or gene fusion analysis is a bioinformatics method for detecting gene fusions in one organism by comparing its genome to that of other organisms. The occurrence of gene fusions suggests that the two original genes that participated in the fusion are functionally linked, i.e. their gene products interact either as part of a multi-subunit protein complex, or in a metabolic pathway. Gene fusion analysis has been used to identify protein functional links in prokaryotes as well as in eukaryotic model organisms, such as yeast and Drosophila. Results In this study we have extended this approach to include a number of recently sequenced protists, four of which are pathogenic, to identify fusion linked proteins in Trypanosoma brucei, the causative agent of African sleeping sickness. We have also examined the evolution of the gene fusion events identified, to determine whether they can be attributed to fusion or fission, by looking at the conservation of the fused genes and of the individual component genes across the major eukaryotic and prokaryotic lineages. We find relatively limited occurrence of gene fusions/fissions within the protist lineages examined. Our results point to two trypanosome-specific gene fissions, which have recently been experimentally confirmed, one fusion involving proteins involved in the same metabolic pathway, as well as two novel putative functional links between fusion-linked protein pairs. Conclusions This is the first study of protein functional links in T. brucei identified by gene fusion analysis. We have used strict thresholds and only discuss results which are highly likely to be genuine and which either have already been or can be experimentally verified. We discuss the possible impact of the identification of these novel putative protein-protein interactions, to the development of new trypanosome therapeutic drugs.

  2. Bibliometric analysis of scientific production about Linked Data

    Directory of Open Access Journals (Sweden)

    Leandro Dal Pizzol

    2015-09-01

    Full Text Available Introduction: Since Tim Berners-Lee coined the term Linked Data in 2006, many studies have emerged based on this initiative. Whether in the form of information access initiatives, whether in applications based on this data type, the interest in this new way to publish and consume information on the Web is increasingly in focus. Objective: In this paper, we present a bibliometric review with the aim of contributing to a better understanding and clarification of concepts and terms associated with the area of Linked Data. Methodology: We have used the Web of Science (WoS, Scopus, EBSCO and IEEE scientific databases, in order to find the existing studies about Linked Data until October 2012. Results: We have mapped 148 scientific papers that address the above issue, written by 409 authors from 160 institutions from 30 different countries. Through the analysis of the articles, it was found that researches about Linked Data are concentrated in a small authors group, suggesting future research opportunities. Conclusions: Synthesizing the information related to the scientific publications in a given area allows building a theoretical background that supports the development of future researches.

  3. Closed-Loop Analysis of Soft Decisions for Serial Links

    Science.gov (United States)

    Lansdowne, Chatwin A.; Steele, Glen F.; Zucha, Joan P.; Schlesinger, Adam M.

    2013-01-01

    We describe the benefit of using closed-loop measurements for a radio receiver paired with a counterpart transmitter. We show that real-time analysis of the soft decision output of a receiver can provide rich and relevant insight far beyond the traditional hard-decision bit error rate (BER) test statistic. We describe a Soft Decision Analyzer (SDA) implementation for closed-loop measurements on single- or dual- (orthogonal) channel serial data communication links. The analyzer has been used to identify, quantify, and prioritize contributors to implementation loss in live-time during the development of software defined radios. This test technique gains importance as modern receivers are providing soft decision symbol synchronization as radio links are challenged to push more data and more protocol overhead through noisier channels, and software-defined radios (SDRs) use error-correction codes that approach Shannon's theoretical limit of performance.

  4. X linked exudative vitreoretinopathy: clinical features and genetic linkage analysis.

    Science.gov (United States)

    Fullwood, P; Jones, J; Bundey, S; Dudgeon, J; Fielder, A R; Kilpatrick, M W

    1993-03-01

    A four generation family in which familial exudative vitreoretinopathy is inherited as an X linked condition is described. Essentially the condition is one of abnormal vascularisation and signs at birth are those of a retinopathy superficially resembling retinopathy of prematurity, retinal folds, or, in advanced cases, enophthalmos or even phthisis. Prognosis depends on the progression of the retinal changes. The family members, including seven affected males and five obligate carrier females, have been types for 20 DNA markers, and linkage analysis suggests a gene locus either at Xq21.3 or at Xp11. As the latter region includes the locus for the gene for Norrie disease, it is possible that this and X linked vitreoretinopathy are allelic. We can further speculate that the differences in severity of the clinical manifestations are dependent only upon the timing of the insult.

  5. Editorial: Special Issue on Experimental Vibration Analysis

    Science.gov (United States)

    Serra, Roger

    2018-04-01

    The vibratory analyses are particularly present today in the various fields of industry, from aeronautics to manufacturing, from machining and maintenance to civil engineering, to mention a few areas, which have made this special issue a true need. The International Journal of Mechanics & Industry compiles a Special Issue on Experimental Vibration Analysis. More than thirty manuscripts were received by the international scientific committee on the 6th congress AVE2016 and only eight papers have been selected after completing a careful and rigorous peer-review process for the Special Issue, which are briefly summarized below.

  6. Inverse dynamic analysis of general n-link robot manipulators

    International Nuclear Information System (INIS)

    Yih, T.C.; Wang, T.Y.; Burks, B.L.; Babcock, S.M.

    1996-01-01

    In this paper, a generalized matrix approach is derived to analyze the dynamic forces and moments (torques) required by the joint actuators. This method is general enough to solve the problems of any n-link open-chain robot manipulators with joint combinations of R(revolute), P(prismatic), and S(spherical). On the other hand, the proposed matrix solution is applicable to both nonredundant and redundant robotic systems. The matrix notation is formulated based on the Newton-Euler equations under the condition of quasi-static equilibrium. The 4 x 4 homogeneous cylindrical coordinates-Bryant angles (C-B) notation is applied to model the robotic systems. Displacements, velocities, and accelerations of each joint and link center of gravity (CG) are calculated through kinematic analysis. The resultant external forces and moments exerted on the CG of each link are considered as known inputs. Subsequently, a 6n x 6n displacement coefficient matrix and a 6n x 1 external force/moment vector can be established. At last, the joint forces and moments needed for the joint actuators to control the robotic system are determined through matrix inversion. Numerical examples will be illustrated for the nonredundant industrial robots: Bendix AA/CNC (RRP/RRR) and Unimate 2000 spherical (SP/RRR) robots; and the redundant light duty utility arm (LDUA), modified LDUA, and tank waste retrieval manipulator system

  7. Analysis of Links Positions in Landing Gear Mechanism

    Science.gov (United States)

    Brewczyński, D.; Tora, G.

    2014-08-01

    This article contains a kinematic analysis of an aircraft chassis mechanism in a range of positions. The mechanism of the chassis is made up of several smaller subsystems with different functions. The first mechanism is used to eject the chassis before landing (touchdown) and fold it to hatchway after the lift off. The second mechanism is designed to perform rotation of the crossover with the wheel, in order to adjust the position of the wheel to fit it in the limited space in the hold. The third mechanism allows movement of the chassis resulting from the change in length of the damper. To determine the position of the following links of the mechanism calculus of vectors was applied in which unit vectors were used to represent the angular position of the links. The aim of the analysis is to determine the angle of convergence and the angle of heel wheels as a function of the variable length of hydraulic cylinder, length of the shock absorber, length of the regulations rods

  8. Linking Design to Business Strategy Through Functional Analysis

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1997-01-01

    The paper discusses how designers, conducting design projects in specific organization's, can assure that the design of IT is appropriately linked to the organizations overall business strategy. A case study is presented in the form of a design project in a small public organization. Functional...... analysis was used as a means to clarify how a specific needed information system could support the organization's new business strategy. Using functional analysis in the design project had a powerful effect: it seriously challenged the organization's business strategy and revealed that the system...... to the relation between an organization's IT-projects and its business strategy and by suggesting that it is the responsibility of the designers, conducting design projects, to assure that this task is taken proper care of. Practical guidelines for this purpose are given....

  9. HTC Experimental Program: Validation and Calculational Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fernex, F.; Ivanova, T.; Bernard, F.; Letang, E. [Inst Radioprotect and Surete Nucl, F-92262 Fontenay Aux Roses (France); Fouillaud, P. [CEA Valduc, Serv Rech Neutron and Critcite, 21 - Is-sur-Tille (France); Thro, J. F. [AREVA NC, F-78000 Versailles (France)

    2009-05-15

    In the 1980's a series of the Haut Taux de Combustion (HTC) critical experiments with fuel pins in a water-moderated lattice was conducted at the Apparatus B experimental facility in Valduc (Commissariat a I'Energie Atomique, France) with the support of the Institut de Radioprotection et de Surete Nucleaire and AREVA NC. Four series of experiments were designed to assess profit associated with actinide-only burnup credit in the criticality safety evaluation for fuel handling, pool storage, and spent-fuel cask conditions. The HTC rods, specifically fabricated for the experiments, simulated typical pressurized water reactor uranium oxide spent fuel that had an initial enrichment of 4. 5 wt% {sup 235}U and was burned to 37.5 GWd/tonne U. The configurations have been modeled with the CRISTAL criticality package and SCALE 5.1 code system. Sensitivity/uncertainty analysis has been employed to evaluate the HTC experiments and to study their applicability for validation of burnup credit calculations. This paper presents the experimental program, the principal results of the experiment evaluation, and modeling. The HTC data applicability to burnup credit validation is demonstrated with an example of spent-fuel storage models. (authors)

  10. Analysis of the interaction between experimental and applied behavior analysis.

    Science.gov (United States)

    Virues-Ortega, Javier; Hurtado-Parrado, Camilo; Cox, Alison D; Pear, Joseph J

    2014-01-01

    To study the influences between basic and applied research in behavior analysis, we analyzed the coauthorship interactions of authors who published in JABA and JEAB from 1980 to 2010. We paid particular attention to authors who published in both JABA and JEAB (dual authors) as potential agents of cross-field interactions. We present a comprehensive analysis of dual authors' coauthorship interactions using social networks methodology and key word analysis. The number of dual authors more than doubled (26 to 67) and their productivity tripled (7% to 26% of JABA and JEAB articles) between 1980 and 2010. Dual authors stood out in terms of number of collaborators, number of publications, and ability to interact with multiple groups within the field. The steady increase in JEAB and JABA interactions through coauthors and the increasing range of topics covered by dual authors provide a basis for optimism regarding the progressive integration of basic and applied behavior analysis. © Society for the Experimental Analysis of Behavior.

  11. Blind links, a big challenge in the linked data idea: Analysis of Persian Subject Headings

    Directory of Open Access Journals (Sweden)

    Atefeh Sharif

    2014-12-01

    Full Text Available In this survey, Linked data concept as exposing, sharing, and connecting pieces of data, information, and knowledge on the Semantic Web and some potential problems in converting Persian subject headings (PSHs Records into linked data were discussed. A data set (11233 records of PSHs was searched in three information retrieval systems including National Library of Iran (NLI online catalog, Library of Congress (LC online catalog and NOSA books. Correct links between Persian and English subject headings in the 9519 common records of two catalogs were recorded. The results indicate that the links between Persian and English subjects in 20% of records were failed. The maximum error was associated with the anonymous databases (6/7 % in NLI online catalog. It is recommended to preprocess the PSHs records before any conversion projects. It seems that, during the preprocessing, the potential errors could be identified and corrected.

  12. Design and Analysis of Underwater Acoustic Networks with Reflected Links

    Science.gov (United States)

    Emokpae, Lloyd

    -of-sight (LOS) and NLOS links by utilizing directional antennas, which will boost the signal-to-noise ratio (SNR) at the receiver while promoting NLOS usage. In our model, we employ a directional underwater acoustic antenna composed of an array of hydrophones that can be summed up at various phases and amplitudes resulting in a beam-former. We have also adopted a practical multimodal directional transducer concept which generates both directional and omni-directional beam patterns by combining the fundamental vibration modes of a cylindrical acoustic radiator. This allows the transducer to be electrically controlled and steered by simply adjusting the electrical voltage weights. A prototype acoustic modem is then developed to utilize the multimodal directional transducer for both LOS and NLOS communication. The acoustic modem has also been used as a platform for empirically validating our SBR communication model in a tank and with empirical data. Networking protocols have been developed to exploit the SBR communication model. These protocols include node discovery and localization, directional medium access control (D-MAC) and geographical routing. In node discovery and localization, each node will utilize SBR-based range measurements to its neighbors to determine their relative position. The D-MAC protocol utilizes directional antennas to increase the network throughput due to the spatial efficiency of the antenna model. In the proposed reflection-enabled directional MAC protocol (RED-MAC), each source node will be able to determine if an obstacle is blocking the LOS link to the destination and switch to the best NLOS link by utilizing surface/bottom reflections. Finally, we have developed a geographical routing algorithm which aims to establish the best stable route from a source node to a destination node. The optimized route is selected to achieve maximum network throughput. Extensive analysis of the network throughput when utilizing directional antennas is also presented

  13. Relativistic analysis of the LISA long range optical links

    International Nuclear Information System (INIS)

    Chauvineau, Bertrand; Regimbau, Tania; Vinet, Jean-Yves; Pireaux, Sophie

    2005-01-01

    The joint ESA/NASA LISA mission consists of three spacecraft on heliocentric orbits, flying in a triangular formation of 5 Mkm each side, linked by infrared optical beams. The aim of the mission is to detect gravitational waves in a low frequency band. For properly processing the scientific data, the propagation delays between spacecraft must be accurately known. We thus analyze the propagation of light between spacecraft in order to systematically derive the relativistic effects due to the static curvature of the Schwarzschild space-time in which the spacecraft are orbiting with time-varying light distances. In particular, our analysis allows us to evaluate rigorously the Sagnac effect, and the gravitational (Einstein) redshift

  14. Analysis of Azari Language based on Parsing using Link Gram

    Directory of Open Access Journals (Sweden)

    Maryam Arabzadeh

    2014-09-01

    Full Text Available There are different classes of theories for the natural lanuguage syntactic parsing problem and for creating the related grammars .This paper presents a syntactic grammar developed in the link grammar formalism for Turkish which is an agglutinative language. In the link grammar formalism, the words of a sentence are linked with each other depending on their syntactic roles. Turkish has complex derivational and inflectional morphology, and derivational and inflection morphemes play important syntactic roles in the sentences. In order to develop a link grammar for Turkish, the lexical parts in the morphological representations of Turkish words are removed, and the links are created depending on the part of speech tags and inflectional morphemes in words. Furthermore, a derived word is separated at the derivational boundaries in order to treat each derivation morpheme as a special distinct word, and allow it to be linked with the rest of the sentence. The derivational morphemes of a word are also linked with each other with special links to indicate that they are parts of the same word. Finally the adapted unique link grammar formalism for Turkish provides flexibility for the linkage construction, and similar methods can be used for other languages with complex morphology. Finally, using the Delphi programming language, the link grammar related to the Azeri language was developed and implemented and then by selecting 250 random sentences, this grammar is evaluated and then tested. For 84.31% of the sentences, the result set of the parser contains the correct parse.

  15. Experimental evaluation of open-loop UpLink Power Control using ACTS

    Science.gov (United States)

    Dissanayake, Asoka

    1995-01-01

    The present investigation deals with the implementation of open-loop up-link power control using a beacon signal in the down-link frequency band as the control parameter. A power control system was developed and tested using the ACTS satellite. ACTS carries beacon signals in both up- and down-link bands with which the relationship between the up- and down-link fading can be established. A power controlled carrier was transmitted to the ACTS satellite from a NASA operated ground station and the transponded signal was received at COMSAT Laboratories using a terminal that was routinely used to monitor the two ACTS beacon signals. The experiment ran for a period of approximately six months and the collected data were used to evaluate the performance of the power control system. A brief review of propagation factors involved in estimating the up-link fade using a beacon signal in the down-link band are presented. The power controller design and the experiment configuration are discussed. Results of the experiment are discussed.

  16. The Role of the Media in Body Image Concerns among Women: A Meta-Analysis of Experimental and Correlational Studies

    Science.gov (United States)

    Grabe, Shelly; Ward, L. Monique; Hyde, Janet Shibley

    2008-01-01

    Research suggests that exposure to mass media depicting the thin-ideal body may be linked to body image disturbance in women. This meta-analysis examined experimental and correlational studies testing the links between media exposure to women's body dissatisfaction, internalization of the thin ideal, and eating behaviors and beliefs with a sample…

  17. Experimental characterization of a 400 Gbit/s orbital angular momentum multiplexed free-space optical link over 120 m.

    Science.gov (United States)

    Ren, Yongxiong; Wang, Zhe; Liao, Peicheng; Li, Long; Xie, Guodong; Huang, Hao; Zhao, Zhe; Yan, Yan; Ahmed, Nisar; Willner, Asher; Lavery, Martin P J; Ashrafi, Nima; Ashrafi, Solyman; Bock, Robert; Tur, Moshe; Djordjevic, Ivan B; Neifeld, Mark A; Willner, Alan E

    2016-02-01

    We experimentally demonstrate and characterize the performance of a 400-Gbit/s orbital angular momentum (OAM) multiplexed free-space optical link over 120 m on the roof of a building. Four OAM beams, each carrying a 100-Gbit/s quadrature-phase-shift-keyed channel are multiplexed and transmitted. We investigate the influence of channel impairments on the received power, intermodal crosstalk among channels, and system power penalties. Without laser tracking and compensation systems, the measured received power and crosstalk among OAM channels fluctuate by 4.5 dB and 5 dB, respectively, over 180 s. For a beam displacement of 2 mm that corresponds to a pointing error less than 16.7 μrad, the link bit error rates are below the forward error correction threshold of 3.8×10(-3) for all channels. Both experimental and simulation results show that power penalties increase rapidly when the displacement increases.

  18. Experimental Results for Minimum-Time Trajectory Tracking of a Direct-Drive Three-Link Planar Arm

    Energy Technology Data Exchange (ETDEWEB)

    DRIESSEN,BRIAN; PARKER,GORDON G.

    1999-09-01

    This work is an experimental investigation of the ability of a real three-link direct-drive arm to track model-based minimum-time trajectories that have been found off-line. Sufficiently large velocity gains in the computed torque control law were not achievable with the velocity sensors described herein. This indicates the critical importance of the velocity sensing when attempting to track trajectories that push the envelope of the system's torque capabilities.

  19. Semantic analysis of links in the musical Wikipedia

    DEFF Research Database (Denmark)

    Mølgaard, Lasse Lohilahti; Hansen, Lars Kai; Larsen, Jan

    2008-01-01

    are generated automatically, and they may even maliciously be used to promote certain topics. Wikipedia has been analyzed recently using methods fromWeb and text mining, however, the fact the link structure is different from the Web’s makes this approach questionable. To better understand the link structure...

  20. Experimental analysis with numerical comparison for different thermoelectric generators configurations

    International Nuclear Information System (INIS)

    Favarel, Camille; Bédécarrats, Jean-Pierre; Kousksou, Tarik; Champier, Daniel

    2016-01-01

    Highlights: • 3 experimental TE generators are tested and compared to a numerical model. • Different mass flow rates and temperatures ranges were used. • Maximum output electrical power is guaranty by the use of MPPT DC/DC controllers. • The importance of the occupancy rate for the design of TEG is demonstrated. • The importance of the location of the TE modules is shown. - Abstract: Thermoelectric (TE) energy harvesting is a promising perspective to use waste heat. Due to the low efficiency of thermoelectric materials many analytical and numerical optimization studies have been developed. To be validated, an optimization must necessarily be linked to the experience. There are a lot of results on thermoelectric generators (TEG) based on experiments or model validations. Nevertheless, the validated models concern most of the time one TE module but rarely an entire system. Moreover, these models of complete system mainly concern the optimization of fluid flow rates or of heat exchangers. Our choice is to optimize the number of these modules in a whole system point of view. A numerical model using a software for numerical computation, based on multi-physics equations such as heat transfer, fluid mechanics and thermoelectricity was developed to predict both thermal and electrical powers of TEG. This paper aims to present the experimental validation of this model and shows interesting experimental results on the location of the TE modules. In parallel, an experimental set-up was built to compare and validate this model. This set-up is composed of a thermal loop with a hot gas source, a cold fluid, a hot fin exchanger, a cold tubular exchanger and thermoelectric modules. The number and the place of these modules can be changed to study different configurations. A specific maximum power point tracker DC/DC converter charging a battery is added in order to study the electrical power produced by the TEG. The analysis of the influence of the number of

  1. Performance Analysis of ARQ-Based RF-FSO Links

    KAUST Repository

    Makki, Behrooz

    2017-02-22

    We study the performance of hybrid radio-frequency (RF) and free-space optical (FSO) links using automatic repeat request (ARQ). We derive closed-form expressions for the throughput and outage probability with different channel models. We also evaluate the effect of adaptive power allocation between the ARQ retransmissions on the system performance. The results show that joint implementation of the RF and FSO links leads to substantial performance improvement, compared to the cases with only the RF or the FSO link.

  2. Performance Analysis of ARQ-Based RF-FSO Links

    KAUST Repository

    Makki, Behrooz; Svensson, Tommy; Eriksson, Thomas; Alouini, Mohamed-Slim

    2017-01-01

    evaluate the effect of adaptive power allocation between the ARQ retransmissions on the system performance. The results show that joint implementation of the RF and FSO links leads to substantial performance improvement, compared to the cases with only

  3. Performance Analysis of M-atmospheric FSO Links

    DEFF Research Database (Denmark)

    Lopez-Gonzalez, Francisco J.; Garrido-Balsellss, José María; Jurado-Navas, Antonio

    2016-01-01

    In this paper, a generalization of the Málaga atmospheric optical communications links treated as a finite number of Generalized-K distributed sub-channels is analyzed in terms of the average bit error rate and outage probability....

  4. Assessment of capacity support and scattering in experimental high speed vehicle to vehicle MIMO links

    DEFF Research Database (Denmark)

    Eggers, Patrick Claus F.; Brown, Tim; Olesen, Kim

    2007-01-01

    Preliminary results on the use of the vehicle to vehicle MIMO channel in a rural highway environment are presented. This is looked at both in terms of the available spatial multiplexing through singular value decomposition and also angular distribution within the channel. Results indicate a strong...... predominant line of sight link in general while instances of scattering from other vehicles will cause changes in the Doppler spectrum as well as beamforming jitter....

  5. Experimental observation of the transition from weak link to tunnel junction

    International Nuclear Information System (INIS)

    Muller, C.J.; Ruitenbeek, J.M. van; Jongh, L.J. de

    1992-01-01

    An extension to Morelands break junction technique is developed in order to obtain a clean and stable, mechanically adjustable junction. As a function of an externally applied force the coupling of two electrodes can be varied in vacuum. Experiments are described of a junction with niobium electrodes at 4.2 K which undergo a continuous change in normal resistance R N , from 1 to 10 9 Ω upon applying an increasing force. In this resistance range we discern a transition from a weak link regime to a tunnel regime. The current voltage (I-V) curves are reproducible upon adjustment changes in the whole resistance range. In the weak link regime the two electrodes of the junction are in physical contact with each other. The product of the critical current and normal resistance is compared with predictions of Ambegaokar-Baratoff and Kulik-Omelyanchuk. The product of the excess current and normal resistance shows a logarithmic increase for low R N values and decreases for the highest R N values in the weak link regime. Subharmonic gap structure, originating from multiple Andreev reflections is observed over a wide range of R N . In the transition regime the two electrodes are not in contact but there is still a large overlap of the superconducting and quasiparticle wave functions. In this regime a finite slope in the ''critical current part'' in the current voltage curve is observed. The I-V curves show features characteristic for both a weak link and a tunnel junction. In the tunnel regime there exists a vacuum gap between the electrodes and the Josephson coupling is suppressed. A considerable subgap current is observed, where the product of the subgap current and normal resistance is constant over almost four orders of magnitude of R N . A decreasing conductance near zero bias shows up in this regime. The normal resistance exhibits an exponential behaviour upon variations in the vacuum gap. (orig./WL)

  6. Lexical Link Analysis (LLA) Application: Improving Web Service to Defense Acquisition Visibility Environment (DAVE)

    Science.gov (United States)

    2015-05-01

    1 LEXICAL LINK ANALYSIS (LLA) APPLICATION: IMPROVING WEB SERVICE TO DEFENSE ACQUISITION VISIBILITY ENVIRONMENT(DAVE) May 13-14, 2015 Dr. Ying...REPORT DATE MAY 2015 2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Lexical Link Analysis (LLA) Application...Making 3 2 1 3 L L A Methods • Lexical Link Analysis (LLA) Core – LLA Reports and Visualizations • Collaborative Learning Agents (CLA) for

  7. Numerical and experimental analysis on tensile properties of ...

    Indian Academy of Sciences (India)

    A Shadrach Jeyasekaran

    2014-11-17

    Nov 17, 2014 ... 4 Department of Electronics and Communication Engineering, Sri Sai ... the findings that the numerical analysis is found to be higher than experimental analysis. .... using ANSYS software has showed that the differences of.

  8. Plant DB link - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...e Site Policy | Contact Us Plant DB link - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  9. Fundamentals of statistical experimental design and analysis

    CERN Document Server

    Easterling, Robert G

    2015-01-01

    Professionals in all areas - business; government; the physical, life, and social sciences; engineering; medicine, etc. - benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and t...

  10. Numerically and experimentally analysis of creep

    International Nuclear Information System (INIS)

    Fontanive, J.A.

    1982-11-01

    The problems of creep in concrete are analyzed experimentally and numerically, comparing with classical methods and suggesting a numerical procedure for the solution of these problems. Firstly, fundamentals of viscoelasticity and its application to concrete behaviour representation are presented. Then the theories of Dischinger and Arutyunyan are studied, and a computing numerical solutions are compared in several examples. Finally, experiences on creep and relaxation are described, and its result are analyzed. Some coments on possible future developments are included. (Author) [pt

  11. application of covariance analysis to feed/ ration experimental data

    African Journals Online (AJOL)

    Prince Acheampong

    ABSTRACT. The use Analysis of Covariance (ANOCOVA) to feed/ration experimental data for birds was examined. Correlation and Regression analyses were used to adjust for the covariate – initial weight of the experimental birds. The Fisher's F statistic for the straight forward Analysis of Variance (ANOVA) showed ...

  12. Analysis of Network Vulnerability Under Joint Node and Link Attacks

    Science.gov (United States)

    Li, Yongcheng; Liu, Shumei; Yu, Yao; Cao, Ting

    2018-03-01

    The security problem of computer network system is becoming more and more serious. The fundamental reason is that there are security vulnerabilities in the network system. Therefore, it’s very important to identify and reduce or eliminate these vulnerabilities before they are attacked. In this paper, we are interested in joint node and link attacks and propose a vulnerability evaluation method based on the overall connectivity of the network to defense this attack. Especially, we analyze the attack cost problem from the attackers’ perspective. The purpose is to find the set of least costs for joint links and nodes, and their deletion will lead to serious network connection damage. The simulation results show that the vulnerable elements obtained from the proposed method are more suitable for the attacking idea of the malicious persons in joint node and link attack. It is easy to find that the proposed method has more realistic protection significance.

  13. Experimental design matters for statistical analysis

    DEFF Research Database (Denmark)

    Jensen, Signe Marie; Schaarschmidt, Frank; Onofri, Andrea

    2018-01-01

    , the experimental design is often more or less neglected when analyzing data. Two data examples were analyzed using different modelling strategies: Firstly, in a randomized complete block design, mean heights of maize treated with a herbicide and one of several adjuvants were compared. Secondly, translocation...... of an insecticide applied to maize as a seed treatment was evaluated using incomplete data from an unbalanced design with several layers of hierarchical sampling. Extensive simulations were carried out to further substantiate the effects of different modelling strategies. RESULTS: It was shown that results from sub...

  14. Experimental analysis of ratchetting in elbows

    International Nuclear Information System (INIS)

    Acker, D.; Touboul, F.; Brouard, D.

    1991-01-01

    Despite of their apparent simplicity, elbows or curved tubes are one of the most tested and analyzed structures to the last years when a large effort has been done by CEA in the framework of the European Structural Integrity Working Group in order to reassess the RCC-MR (1985) piping design rules for elbows and straight parts (TOUBOUL (1988-1989)). It is impossible to mention all the authors and an extensive bibliography has been done by BENDJEDIDIA (1987). But nobody in our knowledge has taken care in experimental validation of design rules against ratcheting. With such objectives, an experimental test program has been performed at CEA, in order to appraise the design methods based on shakedown model like 3 S m rule used by ASME section III (1989) in USA or RCC-M (1988) in FRANCE, or based on the efficiency Diagram used by the french design code for Fast Breeder reactors RCC-MR (1985). The first results were published by M. BENDJEDIDIA (1987). They have been completed by additional tests and improved by a better material characterisation

  15. Analysis of sensory ratings data with cumulative link models

    DEFF Research Database (Denmark)

    Christensen, Rune Haubo Bojesen; Brockhoff, Per B.

    2013-01-01

    Examples of categorical rating scales include discrete preference, liking and hedonic rating scales. Data obtained on these scales are often analyzed with normal linear regression methods or with omnibus Pearson chi2 tests. In this paper we propose to use cumulative link models that allow for reg...

  16. Further Analysis of Motorcycle Helmet Effectiveness Using CODES Linked Data

    Science.gov (United States)

    1998-01-01

    Linked data from the Crash Outcome Data Evaluation System (CODES) in seven : states was used by the National Highway Traffic Safety Administration as the : basis of a 1996 Report to Congress on the Benefits of Safety Belts and : Motorcycle Helmets (D...

  17. Experimental analysis of cut welding in aluminium

    DEFF Research Database (Denmark)

    Dorph, Pernille; De Chiffre, Leonardo; Bay, Niels

    1993-01-01

    Cut welding is a newly developed cold pressure welding process. In the present work, an experimental investigation was carried out analyzing the mechanisms involved in cut welding of a block to a strip. Experiments were carried out in technically pure aluminium. The investigation has involved...... tensile testing and metallographic investigations of the welds. The results show that this variant of cut welding is a very reproducible process giving a weld strength equal to 30-40% the strength of the parent material. The experiments have shown that the reason for this relatively low strength...... is an uneven pressure distribution along the weld due to a wave formed during sliding. Attempts to alter the material flow during sliding are presented....

  18. Analysis of Three-Phase Rectifier Systems with Controlled DC-Link Current Under Unbalanced Grids

    DEFF Research Database (Denmark)

    Kumar, Dinesh; Davari, Pooya; Zare, Firuz

    2017-01-01

    Voltage unbalance is the most common disturbance in distribution networks, which give undesirable effects on many grid connected power electronics systems including Adjustable Speed Drive (ASD). Severe voltage unbalance can force three-phase rectifiers into almost single-phase operation, which...... degrades the grid power quality and also imposes a significant negative impact on the ASD system. This major power quality issue affecting the conventional rectifiers can be attenuated by controlling the DC-link current based on an Electronic Inductor (EI) technique. The purpose of this digest...... is to analyze and compare the performance of an EI with a conventional three-phase rectifier under unbalanced grid conditions. Experimental and simulation results validate the proposed mathematical modelling. Further analysis and benchmarking will be provided in the final paper....

  19. Experimental grid connected PV system power analysis

    Science.gov (United States)

    Semaoui, Smail; Abdeladim, Kamel; Arab, Amar Hadj; Boulahchich, Saliha; Amrouche, Said Ould; Yassaa, Noureddine

    2018-05-01

    Almost 80 % of Algerian territory is appropriate for the exploitation of solar energy. The Algerian energetic strategy provides a substantial injection of PV electricity to the national grid. Currently, about 344 MWp of PV arrays which corresponds approximately to 2,34 km2 of module surfaces, are connected on electricity grid over the national territory. The Algerian Northern regions are characterized by strong pollution and high humidity. These phenomena affect the energetic productivity of PV generator. The objective of our study is to analyze experimental grid connected PV system power in coastal locations. Hence, experiments have been conducted on three identical PV systems to determine the electrical performances. Transformer-less inverters are the most attractive for the ground-based photovoltaic (PV) system due to their efficiencies, reduced cost and weight. Besides, the absence of the galvanic isolation generates problems of capacitive leakage current on the AC side and the degradation of the insulation resistance on the DC side of the inverter. In this work, experimental study of the behavior of single-phase inverters without transformers is presented. The main objective of this work is to study the degradation of the insulation resistance at the input of the inverter, and the capacitive leakage current at the output of the inverter. This study was achieved at the CDER on a rainy day of 15/03/2017, on the first PV plant connected to the low voltage network in Algeria. This investigation can help forecasting the PV array energetic production by taking into account natural conditions.

  20. External events analysis for experimental fusion facilities

    International Nuclear Information System (INIS)

    Cadwallader, L.C.

    1990-01-01

    External events are those off-normal events that threaten facilities either from outside or inside the building. These events, such as floods, fires, and earthquakes, are among the leading risk contributors for fission power plants, and the nature of fusion facilities indicates that they may also lead fusion risk. This paper gives overviews of analysis methods, references good analysis guidance documents, and gives design tips for mitigating the effects of floods and fires, seismic events, and aircraft impacts. Implications for future fusion facility siting are also discussed. Sites similar to fission plant sites are recommended. 46 refs

  1. Experimental and principal component analysis of waste ...

    African Journals Online (AJOL)

    The present study is aimed at determining through principal component analysis the most important variables affecting bacterial degradation in ponds. Data were collected from literature. In addition, samples were also collected from the waste stabilization ponds at the University of Nigeria, Nsukka and analyzed to ...

  2. Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses

    Directory of Open Access Journals (Sweden)

    Van Dorsselaer Alain

    2009-02-01

    Full Text Available Abstract Background VPgs are viral proteins linked to the 5' end of some viral genomes. Interactions between several VPgs and eukaryotic translation initiation factors eIF4Es are critical for plant infection. However, VPgs are not restricted to phytoviruses, being also involved in genome replication and protein translation of several animal viruses. To date, structural data are still limited to small picornaviral VPgs. Recently three phytoviral VPgs were shown to be natively unfolded proteins. Results In this paper, we report the bacterial expression, purification and biochemical characterization of two phytoviral VPgs, namely the VPgs of Rice yellow mottle virus (RYMV, genus Sobemovirus and Lettuce mosaic virus (LMV, genus Potyvirus. Using far-UV circular dichroism and size exclusion chromatography, we show that RYMV and LMV VPgs are predominantly or partly unstructured in solution, respectively. Using several disorder predictors, we show that both proteins are predicted to possess disordered regions. We next extend theses results to 14 VPgs representative of the viral diversity. Disordered regions were predicted in all VPg sequences whatever the genus and the family. Conclusion Based on these results, we propose that intrinsic disorder is a common feature of VPgs. The functional role of intrinsic disorder is discussed in light of the biological roles of VPgs.

  3. Experimental comparison of performance degradation from terahertz and infrared wireless links in fog.

    Science.gov (United States)

    Su, Ke; Moeller, Lothar; Barat, Robert B; Federici, John F

    2012-02-01

    We describe a lab setup for analyzing impairments of terahertz (THz) and infrared (IR) free space links caused by local refraction index changes in the signal's propagation paths that could be induced by turbulence, particles, humidity, etc. A THz signal comprising a 2.5 Gb/s data load modulated on a carrier at 625 GHz, is launched through a weather emulating chamber, detected, and its performance analyzed. An IR beam at 1.5 um wavelength carrying the same data load is superposed with the THz beam, propagating through the same weather conditions and also performance analyzed. We modulate the IR channel with a usual non-return-to-zero (NRZ) format but use duobinary coding for driving our THz source, which enables signaling at high data rate and higher output power. As both beams pass through the same channel perturbations and as their degradations are recorded simultaneously we can simultaneously compare the weather impact on both. We investigate scintillation and fog attenuation effects for the THz and IR signals by measuring bit error rates (BER), signal power, and phase front distortions. © 2012 Optical Society of America

  4. Experimental demonstration of a retro-reflective laser communication link on a mobile platform

    Science.gov (United States)

    Nikulin, Vladimir V.; Malowicki, John E.; Khandekar, Rahul M.; Skormin, Victor A.; Legare, David J.

    2010-02-01

    Successful pointing, acquisition, and tracking (PAT) are crucial for the implementation of laser communication links between ground and aerial vehicles. This technology has advantages over the traditional radio frequency communication, thus justifying the research efforts presented in this paper. The authors have been successful in the development of a high precision, agile, digitally controlled two-degree-of-freedom electromechanical system for positioning of optical instruments, cameras, telescopes, and communication lasers. The centerpiece of this system is a robotic manipulator capable of singularity-free operation throughout the full hemisphere range of yaw/pitch motion. The availability of efficient two-degree-of-freedom positioning facilitated the development of an optical platform stabilization system capable of rejecting resident vibrations with the angular and frequency range consistent with those caused by a ground vehicle moving on a rough terrain. This technology is being utilized for the development of a duplex mobile PAT system demonstrator that would provide valuable feedback for the development of practical laser communication systems intended for fleets of moving ground, and possibly aerial, vehicles. In this paper, a tracking system providing optical connectivity between stationary and mobile ground platforms is described. It utilizes mechanical manipulator to perform optical platform stabilization and initial beam positioning, and optical tracking for maintaining the line-of-sight communication. Particular system components and the challenges of their integration are described. The results of field testing of the resultant system under practical conditions are presented.

  5. Experimental analysis of nature-nurture interactions.

    Science.gov (United States)

    Wyman, Robert J

    2005-06-01

    The presumed opposition of nature and nurture has been a major concern of western civilization since its beginnings. Christian theologians interpreted Adam and Eve's eating of the forbidden fruit as the origin of an inherited 'original sin'. Saint Augustine explicitly applied the concept to human mental development, arguing that, because of original sin, children are inclined toward evil and education requires physical punishment. For centuries, it was considered parents' moral and religious obligation, not to nurture their children, in our current sense of that word, but to beat the willfulness out of them. 16thC humanists fought back, arguing that "schools have become torture chambers" while it is adults "who corrupt young minds with evil". Locke's (1690) statement that children are born as a 'white paper' was crucial in rejecting the dogma of an inborn (and sinful) nature. The original sin vs. white paper argument merged with another ancient dichotomy: inborn instinct (which controls animal behavior) vs. the reason and free will which humans have. Darwin made the concept of inherited instinct, common to both man and animals, one cornerstone of his theory of evolution. The 20(th)C saw scientists recast the debate as instinct vs. learning, bitterly argued between behaviorists and ethologists. Laboratory experimentation and field observation showed that behavior could develop without learning but also that conditioning paradigms could powerfully mold behavior. The progress of genetics and neurobiology has led to the modern synthesis that neural development, and hence behavior, results from the interdependent action of both heredity and environment. Copyright 2005 Wiley-Liss, Inc.

  6. Experimental results and analysis on hydrogen combustion

    International Nuclear Information System (INIS)

    Dorofeev, S.B.; Efimenko, A.A.; Kochurko, A.S.; Sidorov, V.P.; Bezmelnitsin, A.V.

    1994-01-01

    The Small-Scale Development Apparatus (SSDA) was constructed to provide a preliminary set of experimental data to characterize the effect of temperature on the ability of hydrogen-air-steam-mixtures to undergo detonations and, equally important, to support design of the larger-scale High-Temperature Combustion Facility (HTCF) by providing a test bed for solution of a number of high-temperature design and operational problems. The SSDA, the central element of which is 10-cm inside diameter, 6.1-m long tubular test vessel designed to permit detonation experiments at temperatures up to 700K, was employed to study self-sustained detonations in gaseous mixtures of hydrogen, air, and steam at temperature between 300K and 650K at a fixed pressure of 0.1 MPa. Detonation cell size measurements provide clear evidence that the effect of hydrogen-air gas mixture temperature, in the range 300K to 650K, is to decrease cell size and, hence, to increase the sensitivity of the mixture to undergo detonations. The effect of steam content, at any given temperature, is to increase the cell size and, thereby, to decrease the sensitivity of stoichiometric hydrogen-air mixtures. The one-dimensional ZND model does a very good job at predicting the overall trends in the cell size data over the range of hydrogen-air-steam mixture compositions and temperature studied in the experiments. Experiments were conducted to measure the rate of hydrogen oxidation in the absence of ignition sources at temperatures of 500K and 650K, for hydrogen-air mixtures of 15% and 50%, and for a mixture of equimolar hydrogen-air and 30% steam at 650K. The rate of hydrogen oxidation was found to be significant at 650K. Reduction of hydrogen concentration by chemical reaction from 50 to 44% hydrogen, and from 15 to 11% hydrogen, were observed on a time frame of minutes. The DeSoete rate equation predicts the 50% experiment very well, but greatly underestimates the reaction rate of the lean mixtures

  7. Evolution of apomixis loci in Pilosella and Hieracium (Asteraceae) inferred from the conservation of apomixis-linked markers in natural and experimental populations

    Science.gov (United States)

    Hand, M L; Vít, P; Krahulcová, A; Johnson, S D; Oelkers, K; Siddons, H; Chrtek, J; Fehrer, J; Koltunow, A M G

    2015-01-01

    The Hieracium and Pilosella (Lactuceae, Asteraceae) genera of closely related hawkweeds contain species with two different modes of gametophytic apomixis (asexual seed formation). Both genera contain polyploid species, and in wild populations, sexual and apomictic species co-exist. Apomixis is known to co-exist with sexuality in apomictic Pilosella individuals, however, apomictic Hieracium have been regarded as obligate apomicts. Here, a developmental analysis of apomixis within 16 Hieracium species revealed meiosis and megaspore tetrad formation in 1 to 7% of ovules, for the first time indicating residual sexuality in this genus. Molecular markers linked to the two independent, dominant loci LOSS OF APOMEIOSIS (LOA) and LOSS OF PARTHENOGENESIS (LOP) controlling apomixis in Pilosella piloselloides subsp. praealta were screened across 20 phenotyped Hieracium individuals from natural populations, and 65 phenotyped Pilosella individuals from natural and experimental cross populations, to examine their conservation, inheritance and association with reproductive modes. All of the tested LOA and LOP-linked markers were absent in the 20 Hieracium samples irrespective of their reproductive mode. Within Pilosella, LOA and LOP-linked markers were essentially absent within the sexual plants, although they were not conserved in all apomictic individuals. Both loci appeared to be inherited independently, and evidence for additional genetic factors influencing quantitative expression of LOA and LOP was obtained. Collectively, these data suggest independent evolution of apomixis in Hieracium and Pilosella and are discussed with respect to current knowledge of the evolution of apomixis. PMID:25026970

  8. 3-D Experimental Fracture Analysis at High Temperature

    Energy Technology Data Exchange (ETDEWEB)

    John H. Jackson; Albert S. Kobayashi

    2001-09-14

    T*e, which is an elastic-plastic fracture parameter based on incremental theory of plasticity, was determined numerically and experimentally. The T*e integral of a tunneling crack in 2024-T3 aluminum, three point bend specimen was obtained through a hybrid analysis of moire interferometry and 3-D elastic-plastic finite element analysis. The results were verified by the good agreement between the experimentally and numerically determined T*e on the specimen surface.

  9. Experimental studies of control concepts for a parallel manipulator with flexible links

    International Nuclear Information System (INIS)

    Burkhardt, Markus; Eberhard, Peter; Seifried, Robert

    2015-01-01

    Control of flexible multibody systems, such as flexible manipulators, is a challenging task. This is especially true if end-effector trajectory tracking is aspired. On the one hand, these systems require a large number of generalized coordinates to describe their dynamical behavior accurately. On the other hand, only a small subset of these values can be measured or reconstructed on-the-fly. Hence, it is difficult, if not nearly impossible, to use a state controller. In addition, flexible systems are under actuated, i.e. they possess less control inputs than generalized coordinates. In case of a non-collocated output controller, which is the case for end-effector trajectory tracking, the closed loop of the system might lose passivity and is non-minimum phase. In order to achieve end-effector trajectory tracking, exact and approximate feed-forward controls can be applied. In this work, two different versions of such concepts are compared experimentally. These model-based concepts are computed off-line and they supply, next to the required input values, a C1 -continuous solution of the complete state vector which can be used for feedback control. If the system is non-minimum phase, a two-sided boundary value problem has to be solved and the solution includes a pre-actuation as well as a post-actuation phase. While the exact method incorporates all dynamical effects of the flexible multibody system, the approximate concepts neglect certain implications, for example the dynamical effects due to the flexibility. In addition to the presentation of the theoretical basics of the control approaches and the underlying models, this contribution addresses some of the crucial obstacles, which have to be overcome for the operation of the test bench, e.g., signal conditioning, state reconstruction and friction compensation. Since the installed sensors do not allow the direct measurement of the end effector position, image tracking is used to judge the quality of the different

  10. Experimental and model based investigation of the links between snow bidirectional reflectance and snow microstructure

    Science.gov (United States)

    Dumont, M.; Flin, F.; Malinka, A.; Brissaud, O.; Hagenmuller, P.; Dufour, A.; Lapalus, P.; Lesaffre, B.; Calonne, N.; Rolland du Roscoat, S.; Ando, E.

    2017-12-01

    Snow optical properties are unique among Earth surface and crucial for a wide range of applications. The bi-directional reflectance, hereafter BRDF, of snow is sensible to snow microstructure. However the complex interplays between different parameters of snow microstructure namely size parameters and shape parameters on reflectance are challenging to disentangle both theoretically and experimentally. An accurate understanding and modelling of snow BRDF is required to correctly process satellite data. BRDF measurements might also provide means of characterizing snow morphology. This study presents one of the very few dataset that combined bi-directional reflectance measurements over 500-2500 nm and X-ray tomography of the snow microstructure for three different snow samples and two snow types. The dataset is used to evaluate the approach from Malinka, 2014 that relates snow optical properties to the chord length distribution in the snow microstructure. For low and medium absorption, the model accurately reproduces the measurements but tends to slightly overestimate the anisotropy of the reflectance. The model indicates that the deviation of the ice chord length distribution from an exponential distribution, that can be understood as a characterization of snow types, does not impact the reflectance for such absorptions. The simulations are also impacted by the uncertainties in the ice refractive index values. At high absorption and high viewing/incident zenith angle, the simulations and the measurements disagree indicating that some of the assumptions made in the model are not met anymore. The study also indicates that crystal habits might play a significant role for the reflectance under such geometries and wavelengths. However quantitative relationship between crystal habits and reflectance alongside with potential optical methodologies to classify snow morphology would require an extended dataset over more snow types. This extended dataset can likely be obtained

  11. Diallel analysis for sex-linked and maternal effects.

    Science.gov (United States)

    Zhu, J; Weir, B S

    1996-01-01

    Genetic models including sex-linked and maternal effects as well as autosomal gene effects are described. Monte Carlo simulations were conducted to compare efficiencies of estimation by minimum norm quadratic unbiased estimation (MINQUE) and restricted maximum likelihood (REML) methods. MINQUE(1), which has 1 for all prior values, has a similar efficiency to MINQUE(θ), which requires prior estimates of parameter values. MINQUE(1) has the advantage over REML of unbiased estimation and convenient computation. An adjusted unbiased prediction (AUP) method is developed for predicting random genetic effects. AUP is desirable for its easy computation and unbiasedness of both mean and variance of predictors. The jackknife procedure is appropriate for estimating the sampling variances of estimated variances (or covariances) and of predicted genetic effects. A t-test based on jackknife variances is applicable for detecting significance of variation. Worked examples from mice and silkworm data are given in order to demonstrate variance and covariance estimation and genetic effect prediction.

  12. User's manual of JT-60 experimental data analysis system

    International Nuclear Information System (INIS)

    Hirayama, Takashi; Morishima, Soichi; Yoshioka, Yuji

    2010-02-01

    In the Japan Atomic Energy Agency Naka Fusion Institute, a lot of experiments have been conducted by using the large tokamak device JT-60 aiming to realize fusion power plant. In order to optimize the JT-60 experiment and to investigate complex characteristics of plasma, JT-60 experimental data analysis system was developed and used for collecting, referring and analyzing the JT-60 experimental data. Main components of the system are a data analysis server and a database server for the analyses and accumulation of the experimental data respectively. Other peripheral devices of the system are magnetic disk units, NAS (Network Attached Storage) device, and a backup tape drive. This is a user's manual of the JT-60 experimental data analysis system. (author)

  13. Linking soil chemistry, treeline shifts and climate change: scenario modeling using an experimental approach

    Science.gov (United States)

    Mavris, Christian; Furrer, Gerhard; Anderson, Susanne; Blum, Alex; Wells, Aaron; Dahms, Dennis; Egli, Markus

    2014-05-01

    Climate change and global warming have a strong influence on the landscape development. As cold areas become warmer, both flora and fauna must adapt to new conditions (a). It is widely accepted that climate changes deeply influence the treeline shifts. In addition to that, wildfires, plant diseases and insect infestation (i.e. mountain pine beetle) can promote a selective replacement of plants, inhibiting some and favoring others, thus modifying the ecosystem in diverse ways. There is little knowledge on the behavior of soil chemistry when such changes occur. Will elemental availability become a crucial factor as a function of climate changes? The Sinks Canyon and Stough Basin - SE flank of the Wind River Range, Wyoming, USA - offer an ideal case study. Conceptually, the areas were divided into three main subsets: tundra, forest and a subarid environment. All soils were developed on granitoid moraines (b, c). From each subset, a liquid topsoil extract was produced and mixed with the solid subsoil samples in batch reactors at 50 °C. The batch experiments were carried out over 1800 h, and the progress of the dissolution was regularly monitored by analyzing liquid aliquots using IC and ICP-OES. The nutrients were mostly released within the first hours of the experiment. Silicon and Al were continuously released into the solution, while some alkali elements - i.e. Na - showed a more complex trend. Organic acids (acetic, citric) and other ligands produced during biodegradation played an active role in mineral dissolution and nutrient release. The mineral colloids detected in the extract (X-ray diffraction) can significantly control surface reactions (adsorption/desorption) and contributed to specific cationic concentrations. The experimental set up was then compared to a computed dissolution model using SerialSTEADYQL software (d, e). Decoding the mechanisms driving mineral weathering is the key to understand the main geochemical aspects of adaptation during climate

  14. Mutational analysis of the genome-linked protein of cowpea mosaic virus

    NARCIS (Netherlands)

    Carette, J.E.; Kujawa, A.; Gühl, K.; Verver, J.; Wellink, J.; Kammen, van A.

    2001-01-01

    In this study we have performed a mutational analysis of the cowpea mosaic comovirus (CPMV) genome-linked protein VPg to discern the structural requirements necessary for proper functioning of VPg. Either changing the serine residue linking VPg to RNA at a tyrosine or a threonine or changing the

  15. Vibro-acoustic modelling of aircraft double-walls with structural links using Statistical Energy Analysis

    Science.gov (United States)

    Campolina, Bruno L.

    The prediction of aircraft interior noise involves the vibroacoustic modelling of the fuselage with noise control treatments. This structure is composed of a stiffened metallic or composite panel, lined with a thermal and acoustic insulation layer (glass wool), and structurally connected via vibration isolators to a commercial lining panel (trim). The goal of this work aims at tailoring the noise control treatments taking design constraints such as weight and space optimization into account. For this purpose, a representative aircraft double-wall is modelled using the Statistical Energy Analysis (SEA) method. Laboratory excitations such as diffuse acoustic field and point force are addressed and trends are derived for applications under in-flight conditions, considering turbulent boundary layer excitation. The effect of the porous layer compression is firstly addressed. In aeronautical applications, compression can result from the installation of equipment and cables. It is studied analytically and experimentally, using a single panel and a fibrous uniformly compressed over 100% of its surface. When compression increases, a degradation of the transmission loss up to 5 dB for a 50% compression of the porous thickness is observed mainly in the mid-frequency range (around 800 Hz). However, for realistic cases, the effect should be reduced since the compression rate is lower and compression occurs locally. Then the transmission through structural connections between panels is addressed using a four-pole approach that links the force-velocity pair at each side of the connection. The modelling integrates experimental dynamic stiffness of isolators, derived using an adapted test rig. The structural transmission is then experimentally validated and included in the double-wall SEA model as an equivalent coupling loss factor (CLF) between panels. The tested structures being flat, only axial transmission is addressed. Finally, the dominant sound transmission paths are

  16. Outage Probability Analysis of FSO Links over Foggy Channel

    KAUST Repository

    Esmail, Maged Abdullah; Fathallah, Habib; Alouini, Mohamed-Slim

    2017-01-01

    Outdoor Free space optic (FSO) communication systems are sensitive to atmospheric impairments such as turbulence and fog, in addition to being subject to pointing errors. Fog is particularly severe because it induces an attenuation that may vary from few dBs up to few hundreds of dBs per kilometer. Pointing errors also distort the link alignment and cause signal fading. In this paper, we investigate and analyze the FSO systems performance under fog conditions and pointing errors in terms of outage probability. We then study the impact of several effective communication mitigation techniques that can improve the system performance including multi-hop, transmit laser selection (TLS) and hybrid RF/FSO transmission. Closed-form expressions for the outage probability are derived and practical and comprehensive numerical examples are suggested to assess the obtained results. We found that the FSO system has limited performance that prevents applying FSO in wireless microcells that have a 500 m minimum cell radius. The performance degrades more when pointing errors appear. Increasing the transmitted power can improve the performance under light to moderate fog. However, under thick and dense fog the improvement is negligible. Using mitigation techniques can play a major role in improving the range and outage probability.

  17. Outage Probability Analysis of FSO Links over Foggy Channel

    KAUST Repository

    Esmail, Maged Abdullah

    2017-02-22

    Outdoor Free space optic (FSO) communication systems are sensitive to atmospheric impairments such as turbulence and fog, in addition to being subject to pointing errors. Fog is particularly severe because it induces an attenuation that may vary from few dBs up to few hundreds of dBs per kilometer. Pointing errors also distort the link alignment and cause signal fading. In this paper, we investigate and analyze the FSO systems performance under fog conditions and pointing errors in terms of outage probability. We then study the impact of several effective communication mitigation techniques that can improve the system performance including multi-hop, transmit laser selection (TLS) and hybrid RF/FSO transmission. Closed-form expressions for the outage probability are derived and practical and comprehensive numerical examples are suggested to assess the obtained results. We found that the FSO system has limited performance that prevents applying FSO in wireless microcells that have a 500 m minimum cell radius. The performance degrades more when pointing errors appear. Increasing the transmitted power can improve the performance under light to moderate fog. However, under thick and dense fog the improvement is negligible. Using mitigation techniques can play a major role in improving the range and outage probability.

  18. Floor Heating with Displacement Ventilation: An Experimental and Numerical Analysis

    DEFF Research Database (Denmark)

    Causone, Francesco; Olesen, Bjarne W.; Corgnati, S.P.

    2010-01-01

    The effect of floor heating combined with displacement ventilation (DV) on thermal indoor environments and indoor air quality (IAQ) was studied by means of CFD. The numerical model was validated with experimental data. A typical office room was simulated, and one of the occupants was considered...... to simulate different kinds of contaminant sources, under the same boundary conditions. It was found that DV does not guarantee a better IAQ than full mixing when contaminant sources are not linked to heat sources, even when floor heating is used. Contaminants produced by powerful heat sources require high...

  19. Linked Analysis of East Asia Emission Reduction Pathways

    Science.gov (United States)

    Kim, Y.; Woo, J. H.; Bu, C.; Lee, Y.; Kim, J.; Jang, Y.; Park, M.

    2017-12-01

    Air pollution and its impacts over the Northeast Asia are very severe because of the massive pollutant emissions and high population. Korea has been trying to improve air quality with the enhanced environmental legislation. The air quality over Korea, however, does not entirely dependent on its local emissions. Transboundary air pollution from China highly affects Korean atmosphere. The purpose of this research is to understand role of local and transbounday efforts to improve air quality changes over Korea. In this research, we have tried to set up the multiple emission scenario pathways for Korea and China using IIASA's GAINS (Greenhouse gas - Air pollution Interactions aNd Synergies) modeling framework. More up-to-date growth factors and control policy packets were made using regional socio-economic data and control policy information from local governments and international statistics. Four major scenario pathways, 1) Base (Baseline: current legislation), 2) OTB/OTB(On the book/On the way : existing control measure/planed control measure), 3) BOTW_GHG(Beyond on the way : OTW with GHG reduction plan), 4) BOTW_NH3 (OTW with additional NH3 reduction measure) were developed to represent air quality improvement pathways in consideration of both Korean and Chinese efforts. Strict ambient PM2.5 standards from Seoul metropolitan Air quality Improvement Plan(SAIP) seems too enthusiastic without linking air quality control efforts of China. Step-by-step emission controls and following air quality, control cost, health impact from each scenario will be presented at the conference. This subject is supported by Korea Ministry of Environment as "Climate Change Correspondence Program". And This work was supported under the framework of national strategy project on fine particulate matters by Ministry of Science, ICT and Future Planning.

  20. Data Link Test and Analysis System/ATCRBS Transponder Test System Technical Reference

    Science.gov (United States)

    1990-05-01

    This document references material for personnel using or making software changes : to the Data Link Test and Analysis System (DATAS) for Air Traffic Control Radar : Beacon System (ATCRBS) transponder testing and data collection. This is one of : a se...

  1. Ergodic Capacity Analysis of Free-Space Optical Links with Nonzero Boresight Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique; Alouini, Mohamed-Slim; Cheng, Julian

    2015-01-01

    A unified capacity analysis of a free-space optical (FSO) link that accounts for nonzero boresight pointing errors and both types of detection techniques (i.e. intensity modulation/ direct detection as well as heterodyne detection) is addressed

  2. Anxiety-linked attentional bias and its modification: Illustrating the importance of distinguishing processes and procedures in experimental psychopathology research.

    Science.gov (United States)

    MacLeod, Colin; Grafton, Ben

    2016-11-01

    In this review of research concerning anxiety-linked attentional bias, we seek to illustrate a general principle that we contend applies across the breadth of experimental psychopathology. Specifically, we highlight how maintenance of a clear distinction between process and procedure serves to enhance the advancement of knowledge and understanding, while failure to maintain this distinction can foster confusion and misconception. We show how such clear differentiation has permitted the continuous refinement of assessment procedures, in ways that have led to growing confidence in the existence of the putative attentional bias process of interest, and also increasing understanding of its nature. In contrast, we show how a failure to consistently differentiate between process and procedure has contributed to confusion concerning whether or not attentional bias modification reliably alters anxiety vulnerability and dysfunction. As we demonstrate, such confusion can be avoided by distinguishing the process of attentional bias modification from the procedures that have been employed with the intention of evoking this target process. Such an approach reveals that procedures adopted with the intention of eliciting the attentional bias modification process do not always do so, but that successful evocation of the attentional bias modification process quite reliably alters anxiety symptomatology. We consider some of the specific implications for future research concerning attentional bias modification, while also pointing to the broader implications for experimental psychopathology research in general. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Semantic Linking and Contextualization for Social Forensic Text Analysis

    NARCIS (Netherlands)

    Ren, Z.; van Dijk, D.; Graus, D.; van der Knaap, N.; Henseler, H.; de Rijke, M.; Brynielsson, J.; Johansson, F.

    2013-01-01

    With the development of social media, forensic text analysis is becoming more and more challenging as forensic analysts have begun to include this information source in their practice. In this paper, we report on our recent work related to semantic search in e-discovery and propose the use of entity

  4. Experimental and theoretical analysis of cracking in drying soils

    OpenAIRE

    Lakshmikantha, M.R.

    2009-01-01

    The thesis focuses on the experimental and theoretical aspects of the process of cracking in drying soils. The results and conclusions were drawn from an exhaustive experimental campaign characterised by innovative multidisciplinary aspects incorporating Fracture Mechanics and classical Soil mechanics, aided with image analysis techniques. A detailed study of the previous works on the topic showed the absence of large scale fully monitored laboratory tests, while the existing studies were per...

  5. Morphofunctional analysis of experimental model of esophageal achalasia in rats.

    Science.gov (United States)

    Sabirov, A G; Raginov, I S; Burmistrov, M V; Chelyshev, Y A; Khasanov, R Sh; Moroshek, A A; Grigoriev, P N; Zefirov, A L; Mukhamedyarov, M A

    2010-10-01

    We carried out a detailed analysis of rat model of esophageal achalasia previously developed by us. Manifest morphological and functional disorders were observed in experimental achalasia: hyperplasia of the squamous epithelium, reduced number of nerve fibers, excessive growth of fibrous connective tissue in the esophageal wall, high contractile activity of the lower esophageal sphincter, and reduced motility of the longitudinal muscle layer. Changes in rat esophagus observed in experimental achalasia largely correlate with those in esophageal achalasia in humans. Hence, our experimental model can be used for the development of new methods of disease treatment.

  6. Managing coopetition through horizontal supply chain relations : Linking dyadic and network levels of analysis

    NARCIS (Netherlands)

    Wilhelm, Miriam M.

    2011-01-01

    A growing research stream has expanded the level of analysis beyond single buyer-supplier relations to the network, including supplier-supplier relations. These supplier-supplier relations may constitute a missing link between the traditional analysis of the dyadic and the network level of analysis

  7. Managing coopetition through horizontal supply chain relations : Linking dyadic and network levels of analysis

    NARCIS (Netherlands)

    Wilhelm, Miriam M.

    A growing research stream has expanded the level of analysis beyond single buyer-supplier relations to the network, including supplier-supplier relations. These supplier-supplier relations may constitute a missing link between the traditional analysis of the dyadic and the network level of analysis

  8. Strengthening the weak link: Built Environment modelling for loss analysis

    Science.gov (United States)

    Millinship, I.

    2012-04-01

    Methods to analyse insured losses from a range of natural perils, including pricing by primary insurers and catastrophe modelling by reinsurers, typically lack sufficient exposure information. Understanding the hazard intensity in terms of spatial severity and frequency is only the first step towards quantifying the risk of a catastrophic event. For any given event we need to know: Are any structures affected? What type of buildings are they? How much damaged occurred? How much will the repairs cost? To achieve this, detailed exposure information is required to assess the likely damage and to effectively calculate the resultant loss. Modelling exposures in the Built Environment therefore plays as important a role in understanding re/insurance risk as characterising the physical hazard. Across both primary insurance books and aggregated reinsurance portfolios, the location of a property (a risk) and its monetary value is typically known. Exactly what that risk is in terms of detailed property descriptors including structure type and rebuild cost - and therefore its vulnerability to loss - is often omitted. This data deficiency is a primary source of variations between modelled losses and the actual claims value. Built Environment models are therefore required at a high resolution to describe building attributes that relate vulnerability to property damage. However, national-scale household-level datasets are often not computationally practical in catastrophe models and data must be aggregated. In order to provide more accurate risk analysis, we have developed and applied a methodology for Built Environment modelling for incorporation into a range of re/insurance applications, including operational models for different international regions and different perils and covering residential, commercial and industry exposures. Illustrated examples are presented, including exposure modelling suitable for aggregated reinsurance analysis for the UK and bespoke high resolution

  9. VIRTUAL EXPERIMENTAL ANALYSIS ON CLEANING ELEMENT OF SUGARCANE HARVESTER

    Institute of Scientific and Technical Information of China (English)

    Ma Fanglan; Li Shangping; He Yulin; Meng Yanmei; Chen Weixu

    2005-01-01

    The laws of influence of different factors have been analyzed in order to enhance the working efficiency and fatigue life of the cleaning element in brush shape of the sugarcane harvester.Based on the principle of orthogonal experiment design, the virtual-orthogonal-experimental analysis for the cleaning element is carried out on the finite element analysis (FEA) software-ANSYS after analyzing the nonlinear structural behavior in the working procedure. The results are analyzed with the overall balancing method, and then the optimal combination is got, which is made up of different levels of different factors. Also the optimal combination of design parameters of the cleaning element received from the virtual experimental analysis is conducted an experiment to confirm that the virtual analysis model and results are right, and the effect of factors on the function of the cleaning element is obtained by more analysis and further optimizing.

  10. Causal pathways linking environmental change with health behaviour change: Natural experimental study of new transport infrastructure and cycling to work.

    Science.gov (United States)

    Prins, R G; Panter, J; Heinen, E; Griffin, S J; Ogilvie, D B

    2016-06-01

    Mechanisms linking changes to the environment with changes in physical activity are poorly understood. Insights into mechanisms of interventions can help strengthen causal attribution and improve understanding of divergent response patterns. We examined the causal pathways linking exposure to new transport infrastructure with changes in cycling to work. We used baseline (2009) and follow-up (2012) data (N=469) from the Commuting and Health in Cambridge natural experimental study (Cambridge, UK). Exposure to new infrastructure in the form of the Cambridgeshire Guided Busway was defined using residential proximity. Mediators studied were changes in perceptions of the route to work, theory of planned behaviour constructs and self-reported use of the new infrastructure. Outcomes were modelled as an increase, decrease or no change in weekly cycle commuting time. We used regression analyses to identify combinations of mediators forming potential pathways between exposure and outcome. We then tested these pathways in a path model and stratified analyses by baseline level of active commuting. We identified changes in perceptions of the route to work, and use of the cycle path, as potential mediators. Of these potential mediators, only use of the path significantly explained (85%) the effect of the infrastructure in increasing cycling. Path use also explained a decrease in cycling among more active commuters. The findings strengthen the causal argument that changing the environment led to changes in health-related behaviour via use of the new infrastructure, but also show how some commuters may have spent less time cycling as a result. Copyright © 2016. Published by Elsevier Inc.

  11. Meso-level analysis, the missing link in energy strategies

    International Nuclear Information System (INIS)

    Schenk, Niels J.; Moll, Henri C.; Schoot Uiterkamp, Anton J.M.

    2007-01-01

    Energy is essential for human societies. Energy systems, though, are also associated with several adverse environmental effects. So far societies have been unable to successfully change their energy systems in a way that addresses environmental and health concerns. Lack of policy consensus often resulted in so-called 'stop-go' policies, which were identified as some of the most important barriers regarding successful energy transitions. The lack of policy consensus and coherent long-term strategies may result from a lack of knowledge of energy systems' meso-level dynamics. The meso-level involves the dynamic behaviour of the individual system elements and the coupling of individual technologies, resulting in interdependencies and regimes. Energy systems are at the meso-level characterised by two typical aspects, i.e. dynamics driven by interactions between actors, and heterogeneous characteristics of actors. These aspects give rise to the ineffectiveness of traditional energy policies, which is illustrated with examples from the transport sector and household electricity consumption. We found that analysis of energy systems at the meso-level helps to better understand energy systems. To resolve persistent policy issues, the traditional 'one size fits all' energy policies are not sufficient. In order to tackle the difficult issues, 'redesign of system organisation', 'target group approach', or 'target group induced system re-orientation' are needed

  12. Removal of N-linked glycosylations at acidic pH by PNGase a facilitates hydrogen/deuterium exchange mass spectrometry analysis of N-Linked glycoproteins

    DEFF Research Database (Denmark)

    Jensen, Pernille Foged; Comamala, Gerard; Trelle, Morten Beck

    2016-01-01

    for analysis of the conformational dynamics of N-linked glycoproteins that utilizes the enzyme PNGase A for deglycosylation of labeled peptic N-linked glycopeptides at HDX quench conditions, i.e., acidic pH and low temperature. PNGase A-based deglycosylation is thus performed after labeling (post...

  13. Microbiologic, Pharmacokinetic, and Clinical Effects of Corneal Collagen Cross-Linking on Experimentally Induced Pseudomonas Keratitis in Rabbits.

    Science.gov (United States)

    Cosar, C Banu; Kucuk, Mutlu; Celik, Ekrem; Gonen, Tansu; Akyar, Isin; Serteser, Mustafa; Tokat, Fatma; Ince, Umit

    2015-10-01

    To determine the effects of corneal collagen cross-linking (CXL) on the penetration of topical 0.5% moxifloxacin, on the number of colony-forming units (CFUs) in the cornea, and on the clinical course in a rabbit eye model of experimentally induced Pseudomonas aeruginosa keratitis. In this prospective animal study, experimental Pseudomonas corneal ulcers were induced in 56 corneas of 28 albino New Zealand rabbits. The corneas were randomly divided into the following 4 groups: the control group (14 eyes), the MOX group (moxifloxacin) (14 eyes), the MOX + CXL group (14 eyes), and the CXL group (14 eyes). On day 4 of the experiment, the eyes in the control group were enucleated and CFU counting was performed. On day 10 of the experiment, all eyes were enucleated and CFU counting was performed. In the MOX and MOX + CXL groups, the moxifloxacin level in the cornea, aqueous humor, iris, plasma, and serum was measured by reverse-phase high-performance liquid chromatography. The difference in the corneal CFU count between the MOX group and the MOX + CXL group was not significant (P = 0.317). Clinical improvement was greatest in the MOX + CXL group (P < 0.001). The mean corneal moxifloxacin level was 0.391 ± 0.09 μg·mg in the MOX group versus 0.291 ± 0.09 μg·mg in the MOX + CXL group; as such, CXL did not have a significant effect on antibiotic penetrance (P = 0.386). Clinical improvement was greatest in the MOX + CXL group. The synergistic effect of CXL on corneal ulcer treatment is not through antibiotic penetrance.

  14. SiSn diodes: Theoretical analysis and experimental verification

    KAUST Repository

    Hussain, Aftab M.; Wehbe, Nimer; Hussain, Muhammad Mustafa

    2015-01-01

    We report a theoretical analysis and experimental verification of change in band gap of silicon lattice due to the incorporation of tin (Sn). We formed SiSn ultra-thin film on the top surface of a 4 in. silicon wafer using thermal diffusion of Sn

  15. Experimental bifurcation analysis of an impact oscillator – Determining stability

    DEFF Research Database (Denmark)

    Bureau, Emil; Schilder, Frank; Elmegård, Michael

    2014-01-01

    We propose and investigate three different methods for assessing stability of dynamical equilibrium states during experimental bifurcation analysis, using a control-based continuation method. The idea is to modify or turn off the control at an equilibrium state and study the resulting behavior...

  16. Experimental analysis of nonlinear problems in solid mechanics

    International Nuclear Information System (INIS)

    1982-01-01

    The booklet presents abstracts of papers from the Euromech Colloqium No. 152 held from Sept. 20th to 24th, 1982 in Wuppertal, Federal Republic of Germany. All the papers are dealing with Experimental Analysis of Nonlinear Problems in Solid Mechanics. (RW)

  17. SPINE: SParse eIgengene NEtwork linking gene expression clusters in Dehalococcoides mccartyi to perturbations in experimental conditions.

    Directory of Open Access Journals (Sweden)

    Cresten B Mansfeldt

    Full Text Available We present a statistical model designed to identify the effect of experimental perturbations on the aggregate behavior of the transcriptome expressed by the bacterium Dehalococcoides mccartyi strain 195. Strains of Dehalococcoides are used in sub-surface bioremediation applications because they organohalorespire tetrachloroethene and trichloroethene (common chlorinated solvents that contaminate the environment to non-toxic ethene. However, the biochemical mechanism of this process remains incompletely described. Additionally, the response of Dehalococcoides to stress-inducing conditions that may be encountered at field-sites is not well understood. The constructed statistical model captured the aggregate behavior of gene expression phenotypes by modeling the distinct eigengenes of 100 transcript clusters, determining stable relationships among these clusters of gene transcripts with a sparse network-inference algorithm, and directly modeling the effect of changes in experimental conditions by constructing networks conditioned on the experimental state. Based on the model predictions, we discovered new response mechanisms for DMC, notably when the bacterium is exposed to solvent toxicity. The network identified a cluster containing thirteen gene transcripts directly connected to the solvent toxicity condition. Transcripts in this cluster include an iron-dependent regulator (DET0096-97 and a methylglyoxal synthase (DET0137. To validate these predictions, additional experiments were performed. Continuously fed cultures were exposed to saturating levels of tetrachloethene, thereby causing solvent toxicity, and transcripts that were predicted to be linked to solvent toxicity were monitored by quantitative reverse-transcription polymerase chain reaction. Twelve hours after being shocked with saturating levels of tetrachloroethene, the control transcripts (encoding for a key hydrogenase and the 16S rRNA did not significantly change. By contrast

  18. Linking pinch analysis and bridge analysis to save energy by heat-exchanger network retrofit

    International Nuclear Information System (INIS)

    Bonhivers, Jean-Christophe; Moussavi, Alireza; Alva-Argaez, Alberto; Stuart, Paul R.

    2016-01-01

    to link these tools with the composite curves and concepts from pinch analysis into a consistent method for HEN retrofit. First, the relations between the composite curves, the ETD and the HELD are described, and a method for HEN retrofit which combines the insights from pinch analysis with the recently developed tools is proposed. Then the method is used to reduce energy consumption in three case studies. Comparison between results from pinch analysis and bridge analysis shows that the latter identifies supplementary solutions to save energy. The proposed synthesis fills a gap in pinch analysis, and its concepts can be helpful in the development of software for HEN retrofit.

  19. Multipoint linkage analysis and homogeneity tests in 15 Dutch X-linked retinitis pigmentosa families

    NARCIS (Netherlands)

    Bergen, A. A.; van den Born, L. I.; Schuurman, E. J.; Pinckers, A. J.; van Ommen, G. J.; Bleekers-Wagemakers, E. M.; Sandkuijl, L. A.

    1995-01-01

    Linkage analysis and homogeneity tests were carried out in 15 Dutch families segregating X-linked retinitis pigmentosa (X L R P). The study included segregation data for eight polymorphic DNA markers from the short arm of the human X chromosome. The results of both multipoint linkage analysis in

  20. Optimizing Nuclear Reaction Analysis (NRA) using Bayesian Experimental Design

    International Nuclear Information System (INIS)

    Toussaint, Udo von; Schwarz-Selinger, Thomas; Gori, Silvio

    2008-01-01

    Nuclear Reaction Analysis with 3 He holds the promise to measure Deuterium depth profiles up to large depths. However, the extraction of the depth profile from the measured data is an ill-posed inversion problem. Here we demonstrate how Bayesian Experimental Design can be used to optimize the number of measurements as well as the measurement energies to maximize the information gain. Comparison of the inversion properties of the optimized design with standard settings reveals huge possible gains. Application of the posterior sampling method allows to optimize the experimental settings interactively during the measurement process.

  1. An Experimental Metagenome Data Management and AnalysisSystem

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, Victor M.; Korzeniewski, Frank; Palaniappan, Krishna; Szeto, Ernest; Ivanova, Natalia N.; Kyrpides, Nikos C.; Hugenholtz, Philip

    2006-03-01

    The application of shotgun sequencing to environmental samples has revealed a new universe of microbial community genomes (metagenomes) involving previously uncultured organisms. Metagenome analysis, which is expected to provide a comprehensive picture of the gene functions and metabolic capacity of microbial community, needs to be conducted in the context of a comprehensive data management and analysis system. We present in this paper IMG/M, an experimental metagenome data management and analysis system that is based on the Integrated Microbial Genomes (IMG) system. IMG/M provides tools and viewers for analyzing both metagenomes and isolate genomes individually or in a comparative context.

  2. Exergy analysis of an experimental heat transformer for water purification

    International Nuclear Information System (INIS)

    Rivera, W.; Huicochea, A.; Martinez, H.; Siqueiros, J.; Juarez, D.; Cadenas, E.

    2011-01-01

    First and second law of thermodynamics have been used to analyze the performance of an experimental heat transformer used for water purification. The pure water is produced in the auxiliary condenser delivering an amount of heat, which is recycled into the heat transformer increasing the heat source temperatures and also the internal, external and exergy coefficients of performance. The theoretical and experimental study was divided into two parts. In the first part, a second law analysis was carried out to the experimental system showing that the absorber and the condenser are the components with the highest irreversibilities. In the second part, with the results obtained from the second law analysis, new test runs were carried out at similar conditions than the former but varying only one selected temperature at the time. Comparing the COP (coefficient of performance) between the old and new test runs, it was shown that higher internal, external and exergy coefficients of performance were obtained in all the new test runs. Also it was shown that the ECOP (exergy coefficient of performance) increases with an increment of the amount of the purified water produced and with the decrease of the flow ratio. -- Research highlights: → By the first time an experimental results of a heat transformer for water purification with heat recycling has been presented. → An exergy analysis has been carried out in order to identify the irreversibilities in the main components of the system. → With the results obtained of the second law analysis new experimental test runs were carried out minimizing the system irreversibilities and furthermore increasing the system efficiency.

  3. Lexical Link Analysis Application: Improving Web Service to Acquisition Visibility Portal Phase II

    Science.gov (United States)

    2014-04-30

    bäÉîÉåíÜ=^ååì~ä=^Åèìáëáíáçå= oÉëÉ~êÅÜ=póãéçëáìã= qÜìêëÇ~ó=pÉëëáçåë= sçäìãÉ=ff= = Lexical Link Analysis Application: Improving Web Service to...DATE 30 APR 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Lexical Link Analysis Application: Improving...vocabulary or lexicon, to describe the attributes and surrounding environment of the system. Lexical Link Analysis (LLA) is a form of text mining in which

  4. Lexical Link Analysis Application: Improving Web Service to Acquisition Visibility Portal Phase III

    Science.gov (United States)

    2015-04-30

    ååì~ä=^Åèìáëáíáçå= oÉëÉ~êÅÜ=póãéçëáìã= qÜìêëÇ~ó=pÉëëáçåë= sçäìãÉ=ff= = Lexical Link Analysis Application: Improving Web Service to Acquisition...2015 2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Lexical Link Analysis Application: Improving Web Service...processes. Lexical Link Analysis (LLA) can help, by applying automation to reveal and depict???to decisionmakers??? the correlations, associations, and

  5. Digging in to Link Analysis Researches in Iran and all around the World: a Review Article

    Directory of Open Access Journals (Sweden)

    Fatemeh Nooshinfard

    2011-10-01

    Full Text Available Increasing websites quantity, specially scientific websites, there were many researches with concern of link analysis using webometrics by librarian and other scholars in different academic majors around the world. The purpose of this article was link analysis of all link analysis related papers from the beginning to February 19th 2009. The research based on Weiner, Amick, and Lee searching model in 2008, this study included 96 refereed papers extracted from international databases like Springer, Proquest, Sage, Emerald, IEEE, Science Direct and national databases such as Magiran and SID. These papers were studied focusing on their different parts like authors, affiliated organizations, purpose, methods, tools, keywords, date of publishing, publication, indexing databases and their suggestions. Moreover, analyzing those papers and studying any related models were the other purposes of the current article. The findings have been categorized and analyses in ten different sections.

  6. The BCD of response time analysis in experimental economics.

    Science.gov (United States)

    Spiliopoulos, Leonidas; Ortmann, Andreas

    2018-01-01

    For decisions in the wild, time is of the essence. Available decision time is often cut short through natural or artificial constraints, or is impinged upon by the opportunity cost of time. Experimental economists have only recently begun to conduct experiments with time constraints and to analyze response time (RT) data, in contrast to experimental psychologists. RT analysis has proven valuable for the identification of individual and strategic decision processes including identification of social preferences in the latter case, model comparison/selection, and the investigation of heuristics that combine speed and performance by exploiting environmental regularities. Here we focus on the benefits, challenges, and desiderata of RT analysis in strategic decision making. We argue that unlocking the potential of RT analysis requires the adoption of process-based models instead of outcome-based models, and discuss how RT in the wild can be captured by time-constrained experiments in the lab. We conclude that RT analysis holds considerable potential for experimental economics, deserves greater attention as a methodological tool, and promises important insights on strategic decision making in naturally occurring environments.

  7. Simulative Analysis of Inter-Satellite Optical Wireless Communication (IsOWC) Link with EDFA

    Science.gov (United States)

    Singh, Mehtab; Singh, Navpreet

    2018-04-01

    In this paper, simulative analysis and performance comparison of different EDFA (Erbium-doped fiber amplifier) configurations in a 10 Gbps inter-satellite optical wireless communication (IsOWC) link have been reported for a 5,000 km long link and 1,550 nm operating wavelength. The results show that system in which both pre-amplifier and booster amplifier stages are implemented simultaneously outperforms systems with only pre-amplifier and booster amplifier stage. From the results, it can be seen that by deploying a transmission power level of 15 dBm, a link distance of 9,600 km can be achieved with a quality factor of 6.01 dB and BER (Bit error rate) of 1.07×10-9. Also, in this paper, the performance of an 8×7 Gbps WDM-IsOWC link has been reported. The results show that by using both EDFA pre-amplifier and booster amplifier stages, a link distance of 8,000 km for each channel is achievable with desired performance levels (Q≥6 and BER≤10-9). Also, the effect of channel spacing on the performance of WDM-IsOWC link is investigated. The results show that the received signal has acceptable performance levels when the channel spacing is 100 GHz but when the channel spacing is reduced to 80 GHz, the quality of the received signal degrades and link distance decreases.

  8. SiSn diodes: Theoretical analysis and experimental verification

    KAUST Repository

    Hussain, Aftab M.

    2015-08-24

    We report a theoretical analysis and experimental verification of change in band gap of silicon lattice due to the incorporation of tin (Sn). We formed SiSn ultra-thin film on the top surface of a 4 in. silicon wafer using thermal diffusion of Sn. We report a reduction of 0.1 V in the average built-in potential, and a reduction of 0.2 V in the average reverse bias breakdown voltage, as measured across the substrate. These reductions indicate that the band gap of the silicon lattice has been reduced due to the incorporation of Sn, as expected from the theoretical analysis. We report the experimentally calculated band gap of SiSn to be 1.11 ± 0.09 eV. This low-cost, CMOS compatible, and scalable process offers a unique opportunity to tune the band gap of silicon for specific applications.

  9. New experimental and analysis methods in I-DLTS

    International Nuclear Information System (INIS)

    Pandey, S.U.; Middelkamp, P.; Li, Z.; Eremin, V.

    1998-02-01

    A new experimental apparatus to perform I-DLTS measurements is presented. The method is shown to be faster and more sensitive than traditional double boxcar I-DLTS systems. A novel analysis technique utilizing multiple exponential fits to the I-DLTS signal from a highly neutron irradiated silicon sample is presented with a discussion of the results. It is shown that the new method has better resolution and can deconvolute overlapping peaks more accurately than previous methods

  10. EXPERIMENTAL ANALYSIS OF THE CHARACTERISTIC PERFORMANCE OF STANDALONE PHOTOVOLTAIC SYSTEM

    OpenAIRE

    Birendra Kishore; Anirban Nandy*; O.P. Pandey

    2016-01-01

    This paper demonstrates an insight solar PV Stand Alone system which is a practical model with a halogen light source. At different situations the performance of solar PV cells are analyzed. The system produces power with depending on the change in halogen light intensity & temperature. A theoretical & experimental analysis of the PV cell can be achieved. In this paper the I-V & P-V characteristic of the solar photovoltaic cells with changes in temperature and isolation have been showed. With...

  11. Analysis of Harmonics Suppression by Active Damping Control on Multi Slim DC-link Drives

    DEFF Research Database (Denmark)

    Yang, Feng; Máthé, Lászlo; Lu, Kaiyuan

    2016-01-01

    Compared with conventional dc-link drive, slim dc-link drive is expected to achieve lower cost and longer life time. However, harmonics distortion problem may occur in such drive systems. This paper proposes to use an active damping control method to suppress the harmonic distortion...... with the benefit of low cost and also low loss. A new analysis method, based on the frequency domain impedance model, is presented to explore the mechanism of harmonics suppression. Also, a general method is presented to build the impedance model of a PMSM drive system using Field Oriented Control (FOC) method....... Some design issues, including power levels, current control bandwidth and harmonic interaction, are discussed when the drive system is fed by a weak grid. Case studies on a two-drive system composed by two slim dc-link drive units are provided to verify the proposed analysis method....

  12. Analytical and experimental vibration analysis of BWR pressure vessel internals

    International Nuclear Information System (INIS)

    Krutzik, N.; Schad, O.

    1975-01-01

    This report attempts to evaluate the validity as well as quality of several analytical methods in the light of presently available experimental data for the internals of pressure vessels of boiling-water-reactor-types. The experimental checks were performed after the numerical analysis was completed and showed the accuracy of the numerical results. The analytical investigations were done by finite element programmes - 2-dimensional as well as 3-dimensional, where the effect of the mass distribution with parts of virtual masses on the dynamic response could be studied in depth. The experimental data were collected at various different plants and with different mass correlations. Besides evaluating the dynamic characteristics of the components, tests were also performed to evaluate the vibrations of the pressure vessel relative to the main structure. After analysing extensive recorded data much better understanding of the response under a variety of loading- and boundary conditions could be gained. The comparison of the results of analytical studies with the experimental results made a broad qualitative evaluation possible. (Auth.)

  13. Multipoint linkage analysis in X-linked ocular albinism of the Nettleship-Falls type

    NARCIS (Netherlands)

    Bergen, A. A.; Samanns, C.; Schuurman, E. J.; van Osch, L.; van Dorp, D. B.; Pinckers, A. J.; Bakker, E.; Gal, A.; van Ommen, G. J.; Bleeker-Wagemakers, E. M.

    1991-01-01

    An extensive linkage analysis was performed by studying ten Xp22 loci in ten families segregating for X-linked ocular albinism of the Nettleship-Falls type (XOA). Linkage was confirmed between the XOA locus (OA1) and both DXS16 (theta max = 0.10, zeta max = 4.09) and DXS237 (theta max = 0.12, zeta

  14. Preimplantation genetic diagnosis of X-linked diseases examined by indirect linkage analysis.

    Science.gov (United States)

    Borgulova, I; Putzova, M; Soldatova, I; Krautova, L; Pecnova, L; Mika, J; Kren, R; Potuznikova, P; Stejskal, D

    2015-01-01

    Many centers of assisted reproduction in the Czech Republic offer preimplantation genetic diagnosis with fluorescent in situ hybridization (FISH) to couples requiring preimplantation genetic diagnosis (PGD) of X-linked diseases. However, this process results in discarding all male embryos and is not able to distinguish a carrier or healthy female embryo in X-linked recessive disorders. The main aim of this study was to summarize a six-year period of PGD of X-linked monogenic diseases using indirect linkage analysis. We wanted to accentuate the advantage indirect analysis of PGD using multiple displacement amplification (MDA) followed by short tandem repeat (STR) analysis. We present forty-six PGD cycles, including pre-case haplotyping (PGH) panel, for fifteen X-linked diseases. Embryo transfer was made thirty-eight times and gravidity was confirmed in thirteen female probands with a success rate of pregnancy calculated at 42 %. PGD procedure using MDA amplification followed by STR analysis provides help in identifying genetic defects within embryos prior to implantation. The reliability of the method was also supported by high pregnancy rate compared to other publications, which commonly achieved a 30-35 % success rate (Tab. 2, Fig. 1, Ref. 33).

  15. DMFC anode polarization: Experimental analysis and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, A.; Marchesi, R. [Dipartimento di Energetica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2008-01-03

    Anode two-phase flow has an important influence on DMFC performance and methanol crossover. In order to elucidate two-phase flow influence on anode performance, in this work, anode polarization is investigated combining experimental and modelling approach. A systematic experimental analysis of operating conditions influence on anode polarization is presented. Hysteresis due to operating condition is observed; experimental results suggest that it arises from methanol accumulation and has to be considered in evaluating DMFC performances and measurements reproducibility. A model of DMFC anode polarization is presented and utilised as tool to investigate anode two-phase flow. The proposed analysis permits one to produce a confident interpretation of the main involved phenomena. In particular, it confirms that methanol electro-oxidation kinetics is weakly dependent on methanol concentration and that methanol transport in gas phase produces an important contribution in anode feeding. Moreover, it emphasises the possibility to optimise anode flow rate in order to improve DMFC performance and reduce methanol crossover. (author)

  16. Experimental analysis of an autothermal reformer for automotive purposes

    International Nuclear Information System (INIS)

    Caners, C.; Peppley, B.; Harrison, S.; Oosthuizen, P.

    2004-01-01

    This paper describes the experimental analysis, concomitant with modeling research, to determine improved operating parameters and design of an autothermal reformer. The reformer, utilizing both partial oxidation and steam reforming reactions, along with the water gas shift phenomena is well suited for the mobile application of transportation. This is due to the novel geometry of the autothermal reformer, which seeks to improve the heat transfer characteristics of the process, whereby the exothermic partial oxidation reaction provides the heat energy required to drive the steam reforming reaction, to the point of a thermally neutral system. The paper will present data from the experimental results of reforming iso-octane as a surrogate for gasoline in the form of reformate composition, iso-octane conversion percentages and efficiencies in terms of hydrogen realized per mol of fuel input. (author)

  17. Experimental Bifurcation Analysis Using Control-Based Continuation

    DEFF Research Database (Denmark)

    Bureau, Emil; Starke, Jens

    The focus of this thesis is developing and implementing techniques for performing experimental bifurcation analysis on nonlinear mechanical systems. The research centers around the newly developed control-based continuation method, which allows to systematically track branches of stable...... the resulting behavior, we propose and test three different methods for assessing stability of equilibrium states during experimental continuation. We show that it is possible to determine the stability without allowing unbounded divergence, and that it is under certain circumstances possible to quantify...... and unstable equilibria under variation of parameters. As a test case we demonstrate that it is possible to track the complete frequency response, including the unstable branches, for a harmonically forced impact oscillator with hardening spring nonlinearity, controlled by electromagnetic actuators. The method...

  18. CLMSVault: A Software Suite for Protein Cross-Linking Mass-Spectrometry Data Analysis and Visualization.

    Science.gov (United States)

    Courcelles, Mathieu; Coulombe-Huntington, Jasmin; Cossette, Émilie; Gingras, Anne-Claude; Thibault, Pierre; Tyers, Mike

    2017-07-07

    Protein cross-linking mass spectrometry (CL-MS) enables the sensitive detection of protein interactions and the inference of protein complex topology. The detection of chemical cross-links between protein residues can identify intra- and interprotein contact sites or provide physical constraints for molecular modeling of protein structure. Recent innovations in cross-linker design, sample preparation, mass spectrometry, and software tools have significantly improved CL-MS approaches. Although a number of algorithms now exist for the identification of cross-linked peptides from mass spectral data, a dearth of user-friendly analysis tools represent a practical bottleneck to the broad adoption of the approach. To facilitate the analysis of CL-MS data, we developed CLMSVault, a software suite designed to leverage existing CL-MS algorithms and provide intuitive and flexible tools for cross-platform data interpretation. CLMSVault stores and combines complementary information obtained from different cross-linkers and search algorithms. CLMSVault provides filtering, comparison, and visualization tools to support CL-MS analyses and includes a workflow for label-free quantification of cross-linked peptides. An embedded 3D viewer enables the visualization of quantitative data and the mapping of cross-linked sites onto PDB structural models. We demonstrate the application of CLMSVault for the analysis of a noncovalent Cdc34-ubiquitin protein complex cross-linked under different conditions. CLMSVault is open-source software (available at https://gitlab.com/courcelm/clmsvault.git ), and a live demo is available at http://democlmsvault.tyerslab.com/ .

  19. Can Link Analysis Be Applied to Identify Behavioral Patterns in Train Recorder Data?

    Science.gov (United States)

    Strathie, Ailsa; Walker, Guy H

    2016-03-01

    A proof-of-concept analysis was conducted to establish whether link analysis could be applied to data from on-train recorders to detect patterns of behavior that could act as leading indicators of potential safety issues. On-train data recorders capture data about driving behavior on thousands of routine journeys every day and offer a source of untapped data that could be used to offer insights into human behavior. Data from 17 journeys undertaken by six drivers on the same route over a 16-hr period were analyzed using link analysis, and four key metrics were examined: number of links, network density, diameter, and sociometric status. The results established that link analysis can be usefully applied to data captured from on-vehicle recorders. The four metrics revealed key differences in normal driver behavior. These differences have promising construct validity as leading indicators. Link analysis is one method that could be usefully applied to exploit data routinely gathered by on-vehicle data recorders. It facilitates a proactive approach to safety based on leading indicators, offers a clearer understanding of what constitutes normal driving behavior, and identifies trends at the interface of people and systems, which is currently a key area of strategic risk. These research findings have direct applications in the field of transport data monitoring. They offer a means of automatically detecting patterns in driver behavior that could act as leading indicators of problems during operation and that could be used in the proactive monitoring of driver competence, risk management, and even infrastructure design. © 2015, Human Factors and Ergonomics Society.

  20. Experimental modal analysis of components of the LHC experiments

    CERN Document Server

    Guinchard, M; Catinaccio, A; Kershaw, K; Onnela, A

    2007-01-01

    Experimental modal analysis of components of the LHC experiments is performed with the purpose of determining their fundamental frequencies, their damping and the mode shapes of light and fragile detector components. This process permits to confirm or replace Finite Element analysis in the case of complex structures (with cables and substructure coupling). It helps solving structural mechanical problems to improve the operational stability and determine the acceleration specifications for transport operations. This paper describes the hardware and software equipment used to perform a modal analysis on particular structures such as a particle detector and the method of curve fitting to extract the results of the measurements. This paper exposes also the main results obtained for the LHC Experiments.

  1. Analysis of dc-Link Voltage Switching Ripple in Three-Phase PWM Inverters

    Directory of Open Access Journals (Sweden)

    Marija Vujacic

    2018-02-01

    Full Text Available The three-phase voltage source inverter (VSI is de facto standard in power conversion systems. To realize high power density systems, one of the items to be correctly addressed is the design and selection of the dc-link capacitor in relation to the voltage switching ripple. In this paper, effective formulas for designing the dc-link capacitor as a function of the switching voltage ripple amplitude are obtained, considering the operating conditions such as the modulation index and the output current amplitude. The calculations are obtained considering the requirements and restrictions referring to the high (switching-frequency dc-link voltage ripple component. Analyses have been performed considering the dc source impedance (non-ideal dc voltage source at the switching frequency and a balanced load. Analytical expressions are derived for the dc-link voltage switching ripple amplitude and its maximum value over the fundamental period. Different values of modulation index and output phase angle have been considered and different diagrams are presented. Analytical results were validated both by simulations and comprehensive experimental tests.

  2. High Speed Rail commuting: Efficiency analysis of the Spanish HSR links

    Energy Technology Data Exchange (ETDEWEB)

    Moyano, A.

    2016-07-01

    This paper is centred on the analysis of the commuting High Speed Rail (HSR) links that are possible nowadays in the Spanish network. The large development of the network multiplies the possibilities of travelling for commuting. However, not only the feasibility but also the characteristics of the trip, in terms of ticket cost and time spent on the travel, become essential factors when considering HSR commuting links. This paper presents a person-based methodology focused on travellers’ needs and working schedules constraints, which allow differentiating among connections and identifying those intervals of time spent and costs that are affordable for commuting. (Author)

  3. Experimental investigation of thermal neutron analysis based landmine detection technology

    International Nuclear Information System (INIS)

    Zeng Jun; Chu Chengsheng; Ding Ge; Xiang Qingpei; Hao Fanhua; Luo Xiaobing

    2013-01-01

    Background: Recently, the prompt gamma-rays neutron activation analysis method is wildly used in coal analysis and explosive detection, however there were less application about landmine detection using neutron method especially in the domestic research. Purpose: In order to verify the feasibility of Thermal Neutron Analysis (TNA) method used in landmine detection, and explore the characteristic of this technology. Methods: An experimental system of TNA landmine detection was built based on LaBr 3 (Ce) fast scintillator detector and 252 Cf isotope neutron source. The system is comprised of the thermal neutron transition system, the shield system, and the detector system. Results: On the basis of the TNA, the wide energy area calibration method especially to the high energy area was investigated, and the least detection time for a typical mine was defined. In this study, the 72-type anti-tank mine, the 500 g TNT sample and several interferential objects are tested in loess, red soil, magnetic soil and sand respectively. Conclusions: The experimental results indicate that TNA is a reliable demining method, and it can be used to confirm the existence of Anti-Tank Mines (ATM) and large Anti-Personnel Mines (APM) in complicated condition. (authors)

  4. Analysis of the experimental positron lifetime spectra by neural networks

    International Nuclear Information System (INIS)

    Avdic, S.; Chakarova, R.; Pazsit, I.

    2003-01-01

    This paper deals with the analysis of experimental positron lifetime spectra in polymer materials by using various algorithms of neural networks. A method based on the use of artificial neural networks for unfolding the mean lifetime and intensity of the spectral components of simulated positron lifetime spectra was previously suggested and tested on simulated data [Pazsit et al., Applied Surface Science, 149 (1998), 97]. In this work, the applicability of the method to the analysis of experimental positron spectra has been verified in the case of spectra from polymer materials with three components. It has been demonstrated that the backpropagation neural network can determine the spectral parameters with a high accuracy and perform the decomposition of lifetimes which differ by 10% or more. The backpropagation network has not been suitable for the identification of both the parameters and the number of spectral components. Therefore, a separate artificial neural network module has been designed to solve the classification problem. Module types based on self-organizing map and learning vector quantization algorithms have been tested. The learning vector quantization algorithm was found to have better performance and reliability. A complete artificial neural network analysis tool of positron lifetime spectra has been constructed to include a spectra classification module and parameter evaluation modules for spectra with a different number of components. In this way, both flexibility and high resolution can be achieved. (author)

  5. Experimental and Numerical Analysis of Notched Composites Under Tension Loading

    Science.gov (United States)

    Aidi, Bilel; Case, Scott W.

    2015-12-01

    Experimental quasi-static tests were performed on center notched carbon fiber reinforced polymer (CFRP) composites having different stacking sequences made of G40-600/5245C prepreg. The three-dimensional Digital Image Correlation (DIC) technique was used during quasi-static tests conducted on quasi-isotropic notched samples to obtain the distribution of strains as a function of applied stress. A finite element model was built within Abaqus to predict the notched strength and the strain profiles for comparison with measured results. A user-material subroutine using the multi-continuum theory (MCT) as a failure initiation criterion and an energy-based damage evolution law as implemented by Autodesk Simulation Composite Analysis (ASCA) was used to conduct a quantitative comparison of strain components predicted by the analysis and obtained in the experiments. Good agreement between experimental data and numerical analyses results are observed. Modal analysis was carried out to investigate the effect of static damage on the dominant frequencies of the notched structure using the resulted degraded material elements. The first in-plane mode was found to be a good candidate for tracking the level of damage.

  6. Experimental software for modeling and interpreting educational data analysis processes

    Directory of Open Access Journals (Sweden)

    Natalya V. Zorina

    2017-12-01

    Full Text Available Problems, tasks and processes of educational data mining are considered in this article. The objective is to create a fundamentally new information system of the University using the results educational data analysis. One of the functions of such a system is knowledge extraction from accumulated in the operation process data. The creation of the national system of this type is an iterative and time-consuming process requiring the preliminary studies and incremental prototyping modules. The novelty of such systems is that there is a lack of those using this methodology of the development, for this purpose a number of experiments was carried out in order to collect data, choose appropriate methods for the study and to interpret them. As a result of the experiment, the authors were available sources available for analysis in the information environment of the home university. The data were taken from the semester performance, obtained from the information system of the training department of the Institute of IT MTU MIREA, the data obtained as a result of the independent work of students and data, using specially designed Google-forms. To automate the collection of information and analysis of educational data, an experimental software package was created. As a methodology for developing the experimental software complex, a decision was made using the methodologies of rational-empirical complexes (REX and single-experimentation program technologies (TPEI. The details of the program implementation of the complex are described in detail, conclusions are given about the availability of the data sources used, and conclusions are drawn about the prospects for further development.

  7. Harmonic Coupling Analysis of a Multi-Drive System with Slim DC-link Drive

    DEFF Research Database (Denmark)

    Yang, Feng; Kwon, Jun Bum; Blaabjerg, Frede

    2017-01-01

    One of the problems with slim dc-link adjustable speed drive is the difficulties to analyze the harmonic coupling when it is integrated into a multi-drive system. The traditional methods analyze this harmonic issue by neglecting the harmonic coupling, and base on the linear time-invariant methods....... Its disadvantages include the time consumption and large computer memory. This paper proposes to do harmonic analysis by using the harmonic state-space modeling method by using the linear time-periodic theory. By using the proposed model, the harmonic couplings, between dc-link and point of common...... coupling in different drives, are all analyzed in the multi-drive system. In the meantime, the effects of the small film dc-link capacitance and the nonlinear characteristic of the diode rectifier are considered. The detailed modeling procedure, the simulations and the lab experiment on a two-drive system...

  8. Complex experimental analysis of rifle-shooter interaction

    Directory of Open Access Journals (Sweden)

    Michał Taraszewski, M.ScEng, PhD. candidate

    2017-10-01

    Full Text Available In this study, a complex analysis of a man-weapon interaction based on experimental effort is presented. The attention is focused on how a shooter can influence on a rifle, opposite to generally considered in literature rifle's impact on a shooter. It is shown, based on the kbk AKM weapon, that each support point of the rifle has an substantial impact on the system. It is said that identifying human reactions on weapon may let to describe gun movement and thus may be applied to weapon accuracy determination.

  9. Analysis and discussion on the experimental data of electrolyte analyzer

    Science.gov (United States)

    Dong, XinYu; Jiang, JunJie; Liu, MengJun; Li, Weiwei

    2018-06-01

    In the subsequent verification of electrolyte analyzer, we found that the instrument can achieve good repeatability and stability in repeated measurements with a short period of time, in line with the requirements of verification regulation of linear error and cross contamination rate, but the phenomenon of large indication error is very common, the measurement results of different manufacturers have great difference, in order to find and solve this problem, help enterprises to improve quality of product, to obtain accurate and reliable measurement data, we conducted the experimental evaluation of electrolyte analyzer, and the data were analyzed by statistical analysis.

  10. Remote Experimental Site: A command and analysis center for ''Big Physics'' experimentation

    International Nuclear Information System (INIS)

    Casper, T.A.; Lennon, W.J.

    1991-09-01

    The next generation of tokamaks, ITER or BPX, will be characterized by an even greater emphasis on joint operation and experimentation. With anticipation of an increased number and diversity of collaborations, we are preparing for such shared facilities by developing a systematic approach to remote, joint physics operation involving experimental teams at several locations. The local area network of computers used for control and data acquisition on present and future experiments can be extended over a wide area network to provide a mechanism for remote operation of subsystems required for physics experiments. The technology required for high bandwidth (≥45Mbps) connections between multiple sites either exists or will be available over the next few years. With the rapid development of high performance workstations, network interfaces, distributed computing, and video conferencing, we can proceed with the development of a system of control and analysis sites to provide for consistent, efficient, and continuing collaborations. Early establishment of such sites could also enhance existing joint design and development efforts. 2 refs., 3 figs

  11. Disclosure-Protected Inference with Linked Microdata Using a Remote Analysis Server

    Directory of Open Access Journals (Sweden)

    Chipperfield James O.

    2014-03-01

    Full Text Available Large amounts of microdata are collected by data custodians in the form of censuses and administrative records. Often, data custodians will collect different information on the same individual. Many important questions can be answered by linking microdata collected by different data custodians. For this reason, there is very strong demand from analysts, within government, business, and universities, for linked microdata. However, many data custodians are legally obliged to ensure the risk of disclosing information about a person or organisation is acceptably low. Different authors have considered the problem of how to facilitate reliable statistical inference from analysis of linked microdata while ensuring that the risk of disclosure is acceptably low. This article considers the problem from the perspective of an Integrating Authority that, by definition, is trusted to link the microdata and to facilitate analysts’ access to the linked microdata via a remote server, which allows analysts to fit models and view the statistical output without being able to observe the underlying linked microdata. One disclosure risk that must be managed by an Integrating Authority is that one data custodian may use the microdata it supplied to the Integrating Authority and statistical output released from the remote server to disclose information about a person or organisation that was supplied by the other data custodian. This article considers analysis of only binary variables. The utility and disclosure risk of the proposed method are investigated both in a simulation and using a real example. This article shows that some popular protections against disclosure (dropping records, rounding regression coefficients or imposing restrictions on model selection can be ineffective in the above setting.

  12. A guide to evaluating linkage quality for the analysis of linked data.

    Science.gov (United States)

    Harron, Katie L; Doidge, James C; Knight, Hannah E; Gilbert, Ruth E; Goldstein, Harvey; Cromwell, David A; van der Meulen, Jan H

    2017-10-01

    Linked datasets are an important resource for epidemiological and clinical studies, but linkage error can lead to biased results. For data security reasons, linkage of personal identifiers is often performed by a third party, making it difficult for researchers to assess the quality of the linked dataset in the context of specific research questions. This is compounded by a lack of guidance on how to determine the potential impact of linkage error. We describe how linkage quality can be evaluated and provide widely applicable guidance for both data providers and researchers. Using an illustrative example of a linked dataset of maternal and baby hospital records, we demonstrate three approaches for evaluating linkage quality: applying the linkage algorithm to a subset of gold standard data to quantify linkage error; comparing characteristics of linked and unlinked data to identify potential sources of bias; and evaluating the sensitivity of results to changes in the linkage procedure. These approaches can inform our understanding of the potential impact of linkage error and provide an opportunity to select the most appropriate linkage procedure for a specific analysis. Evaluating linkage quality in this way will improve the quality and transparency of epidemiological and clinical research using linked data. © The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association.

  13. Thermoelectric Generation Of Current - Theoretical And Experimental Analysis

    Science.gov (United States)

    Ruciński, Adam; Rusowicz, Artur

    2017-12-01

    This paper provides some information about thermoelectric technology. Some new materials with improved figures of merit are presented. These materials in Peltier modules make it possible to generate electric current thanks to a temperature difference. The paper indicates possible applications of thermoelectric modules as interesting tools for using various waste heat sources. Some zero-dimensional equations describing the conditions of electric power generation are given. Also, operating parameters of Peltier modules, such as voltage and electric current, are analyzed. The paper shows chosen characteristics of power generation parameters. Then, an experimental stand for ongoing research and experimental measurements are described. The authors consider the resistance of a receiver placed in the electric circuit with thermoelectric elements. Finally, both the analysis of experimental results and conclusions drawn from theoretical findings are presented. Voltage generation of about 1.5 to 2.5 V for the temperature difference from 65 to 85 K was observed when a bismuth telluride thermoelectric couple (traditionally used in cooling technology) was used.

  14. Thermoelectric Generation Of Current – Theoretical And Experimental Analysis

    Directory of Open Access Journals (Sweden)

    Ruciński Adam

    2017-12-01

    Full Text Available This paper provides some information about thermoelectric technology. Some new materials with improved figures of merit are presented. These materials in Peltier modules make it possible to generate electric current thanks to a temperature difference. The paper indicates possible applications of thermoelectric modules as interesting tools for using various waste heat sources. Some zero-dimensional equations describing the conditions of electric power generation are given. Also, operating parameters of Peltier modules, such as voltage and electric current, are analyzed. The paper shows chosen characteristics of power generation parameters. Then, an experimental stand for ongoing research and experimental measurements are described. The authors consider the resistance of a receiver placed in the electric circuit with thermoelectric elements. Finally, both the analysis of experimental results and conclusions drawn from theoretical findings are presented. Voltage generation of about 1.5 to 2.5 V for the temperature difference from 65 to 85 K was observed when a bismuth telluride thermoelectric couple (traditionally used in cooling technology was used.

  15. Analysis of biogas transformation in experimental biogas plant

    Directory of Open Access Journals (Sweden)

    Eva Jelínková

    2011-01-01

    Full Text Available The topic of this paper is the analysis of anaerobic fermentation in an experimental biogas plant. Technological processes and operation parameters were monitored; these processes and parameters include, for example, the optimal structure of the input material and the consideration of the prolonging of the duration of the fermentation process. The goal of prolonging the fermentation process is to obtain higher biogas (and methane production and to decrease the fermentation residue effluvial emissions. Emphasis is also laid on the mutual co-fermentation of substrates with regard to further use of the results in solving technological problems in other biogas plants. This technological process was first monitored in 2009; that is, before the planned intensification and modernization of the experimental biogas plant. Thus, the evaluation of the process could become part of the planned intensification and modernization of the chosen biogas plant (extended by the addition of the second stage of methanogenesis. The results obtained from the experimental biogas plant, which is one of the pioneering biogas plants in the Czech Republic, may serve, to other biogas operators, as a base for the preparation of suitable input, and for improving the efficiency of anaerobic fermentation within their biogas plants. The goal of the improvement of the fermentation process is to fulfill the ecological aspects; that is, to cut down CO2 emissions and to reduce the negative impact of the fermentation process on the environment (reduction of effluvium and noise originating in biogas plants.

  16. Desiccant wheels for air humidification: An experimental and numerical analysis

    International Nuclear Information System (INIS)

    De Antonellis, Stefano; Intini, Manuel; Joppolo, Cesare Maria; Molinaroli, Luca; Romano, Francesco

    2015-01-01

    Highlights: • The use of desiccant wheel to humidify an air stream is investigated. • Air humidification is obtained by extracting water vapour from outdoor air. • Experimental tests in winter humidification conditions are performed. • The design of the proposed humidification system is numerically analyzed. • Effects of boundary conditions on humidification capacity are investigated. - Abstract: In this work the use of a desiccant wheel for air humidification is investigated through a numerical and experimental approach. In the proposed humidification system, water vapour is adsorbed from outdoor environment and it is released directly to the air stream supplied to the building. Such a system can be an interesting alternative to steam humidifiers in hospitals or, more generally, in applications where air contamination is a critical issue and therefore adiabatic humidifiers are not allowed. Performance of the proposed system is deeply investigated and optimal values of desiccant wheel configuration parameters are discussed. It is shown that in the investigated conditions, which are representative of Southern Europe winter climate, the system can properly match the latent load of the building. Finally, power consumption referred to the primary source of the proposed humidification system is compared to the one of steam humidifiers. The present analysis is carried out through experimental tests of a desiccant wheel in winter humidification conditions and through a phenomenological model of the device, based on heat and mass transfer equations.

  17. Statistics in experimental design, preprocessing, and analysis of proteomics data.

    Science.gov (United States)

    Jung, Klaus

    2011-01-01

    High-throughput experiments in proteomics, such as 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), yield usually high-dimensional data sets of expression values for hundreds or thousands of proteins which are, however, observed on only a relatively small number of biological samples. Statistical methods for the planning and analysis of experiments are important to avoid false conclusions and to receive tenable results. In this chapter, the most frequent experimental designs for proteomics experiments are illustrated. In particular, focus is put on studies for the detection of differentially regulated proteins. Furthermore, issues of sample size planning, statistical analysis of expression levels as well as methods for data preprocessing are covered.

  18. Link Performance Analysis and monitoring - A unified approach to divergent requirements

    Science.gov (United States)

    Thom, G. A.

    Link Performance Analysis and real-time monitoring are generally covered by a wide range of equipment. Bit Error Rate testers provide digital link performance measurements but are not useful during real-time data flows. Real-time performance monitors utilize the fixed overhead content but vary widely from format to format. Link quality information is also present from signal reconstruction equipment in the form of receiver AGC, bit synchronizer AGC, and bit synchronizer soft decision level outputs, but no general approach to utilizing this information exists. This paper presents an approach to link tests, real-time data quality monitoring, and results presentation that utilizes a set of general purpose modules in a flexible architectural environment. The system operates over a wide range of bit rates (up to 150 Mbs) and employs several measurement techniques, including P/N code errors or fixed PCM format errors, derived real-time BER from frame sync errors, and Data Quality Analysis derived by counting significant sync status changes. The architecture performs with a minimum of elements in place to permit a phased update of the user's unit in accordance with his needs.

  19. Analysis of experimental biosensor/FIA lactose measurements

    Directory of Open Access Journals (Sweden)

    Ferreira L.S.

    2003-01-01

    Full Text Available Whey is an abundant effluent in the production of cheese and casein. The biotechnological utilization of this economically important and nutritive source is limited mainly because of the presence of high percentages of lactose. This disaccharide has poor solubility, which can cause crystallization and insufficient sweetness in dairy food; additionally, part of the adult population suffers from associated lactose intolerance diseases. There are several methods to determine lactose such as spectrophotometry, polarimetry, infrared spectroscopy, titrimetry and chromatography. However these methods are tedious and time-consuming due to long sample preparation. These disadvantages stimulated the development of an enzymatic lactose biosensor. It employs two immobilized enzymes, beta-galactosidase and glucose oxidase and the quantitative analysis of lactose is based on determination of oxygen consumption in the enzymatic reaction. The influence of temperature on the biosensor signal was experimentally studied. It was observed that a nonlinear relationship exists between the electric response of the biosensor - provided by CAFCA (Computer Assisted Flow Control & Analysis - ANASYSCON, Hannover - and lactose concentration. In this work, attempts were made to correlate these variables using a simple nonlinear model and multilayered neural networks, with the latter providing the best modeling of the experimental data.

  20. Mutation Analysis in Classical Phenylketonuria Patients Followed by Detecting Haplotypes Linked to Some PAH Mutations.

    Science.gov (United States)

    Dehghanian, Fatemeh; Silawi, Mohammad; Tabei, Seyed M B

    2017-02-01

    Deficiency of phenylalanine hydroxylase (PAH) enzyme and elevation of phenylalanine in body fluids cause phenylketonuria (PKU). The gold standard for confirming PKU and PAH deficiency is detecting causal mutations by direct sequencing of the coding exons and splicing involved sequences of the PAH gene. Furthermore, haplotype analysis could be considered as an auxiliary approach for detecting PKU causative mutations before direct sequencing of the PAH gene by making comparisons between prior detected mutation linked-haplotypes and new PKU case haplotypes with undetermined mutations. In this study, 13 unrelated classical PKU patients took part in the study detecting causative mutations. Mutations were identified by polymerase chain reaction (PCR) and direct sequencing in all patients. After that, haplotype analysis was performed by studying VNTR and PAHSTR markers (linked genetic markers of the PAH gene) through application of PCR and capillary electrophoresis (CE). Mutation analysis was performed successfully and the detected mutations were as follows: c.782G>A, c.754C>T, c.842C>G, c.113-115delTCT, c.688G>A, and c.696A>G. Additionally, PAHSTR/VNTR haplotypes were detected to discover haplotypes linked to each mutation. Mutation detection is the best approach for confirming PAH enzyme deficiency in PKU patients. Due to the relatively large size of the PAH gene and high cost of the direct sequencing in developing countries, haplotype analysis could be used before DNA sequencing and mutation detection for a faster and cheaper way via identifying probable mutated exons.

  1. Analytic analysis of auxetic metamaterials through analogy with rigid link systems

    OpenAIRE

    Rayneau-Kirkhope, Daniel; Zhang, Chengzhao; Theran, Louis; Dias, Marcelo A.

    2017-01-01

    Recent progress in advanced additive manufacturing techniques has stimulated the growth of the field of mechanical metamaterials. One area particular interest in this subject is the creation of auxetic material properties through elastic instability. This paper focuses on a novel methodology in the analysis of auxetic metamaterials through analogy with rigid link lattice systems. Our analytic methodology gives extremely good agreement with finite element simulations for both the onset of elas...

  2. Inequality and adolescent cannabis use: A qualitative comparative analysis of the link at national level

    OpenAIRE

    Stevens, Alex

    2016-01-01

    Aim: This article explores the link between income inequality and adolescent cannabis use at the national level, in the context of other relevant social conditions, in developed countries. Methods and data: Fuzzy set qualitative comparative analysis is applied to two data sets that contain information on the national prevalence of past year cannabis use among 15 and 16 year olds, taken from the ESPAD and HBSC surveys, with supplementary data from the MtF and ASSAD surveys for the USA and Aust...

  3. Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis

    NARCIS (Netherlands)

    Ronday, H.K.; TeKoppele, J.M.; Greenwald, R.A.; Moak, S.A.; Roos, J.A.D.M. de; Dijkmans, B.A.C.; Breedveld, F.C.; Verheijen, J.H.

    1998-01-01

    The plasminogen activation system is one of the enzyme systems held responsible for bone and cartilage degradation in rheumatoid arthritis (RA). In this study, we evaluated the effect of tranexamic acid (TEA), an inhibitor of plasminogen activation, on urinary collagen cross-link excretion and

  4. Identifying Effective Spelling Interventions Using a Brief Experimental Analysis and Extended Analysis

    Science.gov (United States)

    McCurdy, Merilee; Clure, Lynne F.; Bleck, Amanda A.; Schmitz, Stephanie L.

    2016-01-01

    Spelling is an important skill that is crucial to effective written communication. In this study, brief experimental analysis procedures were used to examine spelling instruction strategies (e.g., whole word correction; word study strategy; positive practice; and cover, copy, and compare) for four students. In addition, an extended analysis was…

  5. Carbon auctions, energy markets and market power: An experimental analysis

    International Nuclear Information System (INIS)

    Dormady, Noah C.

    2014-01-01

    This paper provides an experimental analysis of a simultaneous energy-emissions market under conditions of market power. The experimental design employs real-world institutional features; including stochastic demand, permit banking, inter-temporal (multi-round) dynamics, a tightening cap, and resale. The results suggest that dominant firms can utilize energy-emissions market linkages to simultaneously inflate the price of energy and suppress the price of emissions allowances. Whereas under prior market designs, regulators were concerned with dominant firms exercising their market power over the emissions market to exclude rivals and manipulate the permit market by hoarding permits; the results of this paper suggest that this strategy is less profitable to dominant firms in contemporary auction-based markets than strategic capacity withholding in the energy market and associated demand reduction in the emissions market. - Highlights: • Laboratory simulation of joint energy-emissions market. • Evaluates market power under collusion and real-world institutional features. • Dominant firms can exercise market power to inflate energy prices. • Dominant firms can exercise market power to suppress emissions prices. • Supply withholding is an implicit demand reduction in the emissions market

  6. Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults

    Science.gov (United States)

    Corradi, Marco; Borri, Antonio; Castori, Giulio; Coventry, Kathryn

    2015-01-01

    An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers). For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L’Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults. PMID:28793697

  7. Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults.

    Science.gov (United States)

    Corradi, Marco; Borri, Antonio; Castori, Giulio; Coventry, Kathryn

    2015-11-27

    An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers). For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L'Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults.

  8. Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults

    Directory of Open Access Journals (Sweden)

    Marco Corradi

    2015-11-01

    Full Text Available An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers. For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L’Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults.

  9. Experimental analysis of natural convection within a thermosyphon

    International Nuclear Information System (INIS)

    Clarksean, R.

    1993-01-01

    The heat transfer characteristics of a thermosyphon designed to passively cool cylindrical heat sources are experimentally studied. The analysis is based on recognizing the physics of the flow within different regions of the thermosyphon to develop empirical heat transfer correlations. The basic system consists of three concentric cylinders, with an outer channel between the outer two cylinders, and an inner channel between the inner two cylinders. Tests were conducted. with two different process material container diameters, representing the inner cylinder, and several different power levels. The experimentally determined local and average Nu numbers for the inner channel are in good agreement with previous work for natural convection between vertical parallel plates, one uniformly heated and the other thermally insulated. The implication is that the heat transfer off of each surface is independent of the adjacent surface for sufficiently high Ra numbers. The heat transfer is independent because of limited interaction between the boundary layers at sufficiently high Ra numbers. As a result of the limited interaction, the maximum temperature within the system remained constant, or decreased slightly when the radii of the inner cylinders increased for the same amount of heat removal

  10. Analysis of Elektrogorsk 108 test facility experimental data

    International Nuclear Information System (INIS)

    Urbonas, R.

    2001-01-01

    In the paper an evaluation of experimental data obtained at Russian Elektrogorsk 108 (E-108) test facility is presented. E-108 facility is a scaled model of Russian RBMK design reactor. An attempt to validate state-of-the-art thermal hydraulic codes on the basis of E-108 test facility was made. Originally these codes were developed and validated for BWRs and PWRs. Since state-of-art thermal hydraulic codes are widely used for simulation of RBMK reactors further codes' implementation and validation is required. The facility was modelled by employing RELAP5 (INEEL, USA) thermal hydraulic system analysis best estimate code. The results show dependence from number of nodes used in the heated channels, frictional and form losses employed. The obtained oscillatory behaviour is resulted by density wave and critical heat flux. It is shown that codes are able to predict thermal hydraulic instability and sudden heat structure temperature excursion, when critical heat flux is approached, well. In addition, an uncertainty analysis of one of the experiments was performed by employing GRS developed System for Uncertainty and Sensitivity Analysis (SUSA). It was one of the first attempts to use this statistic-based methodology in Lithuania.(author)

  11. Experimental analysis of plastic materials containing radionuclides for decontamination viability

    International Nuclear Information System (INIS)

    Tazaki, Kazue; Nakano, Mikio; Takehara, Teruaki; Ishigaki, Yasuhito; Nakagawa, Hideaki

    2015-01-01

    After the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident on 11 March, 2011, the high radioactive dosage was found in polluted water for agriculture use at Baba, Haramachi, Minami-Soma, Fukushima Prefecture, Japan. Field experiment for decontamination of water had been studied by using commercial plastic materials. The agricultural water comes from Tetsuzan dam is full of radioactive-contaminated water. Experimental analysis showed that the plastic materials can take up radioactive elements for several months soaked in the polluted agricultural water. The quantitative analyses using X-ray fluorescence analysis, Ge semiconductor and scanning electron microscopy equipped with energy dispersive X-ray spectrometer (SEM-EDS), revealed the detection of the radionuclides on the plastic materials with diatom and clays. The results suggest the adsorption of radionuclides on the surface of plastic materials due to FDNPP accident. The plastic materials associated with clays and diatoms could be stronger carriers of radionuclides in the polluted water. Adherence of diatoms to the plastic fiber in the water for 7 months suggested that some plastic materials were taking up heavy metals (Zn, Ba, Pb, Sb) with radioactive elements (Cs etc.). Mechanisms by which radioactive pollutants and microorganisms are adsorbed onto and desorbed from clays at aqueous interface can be understood by combining chemical analysis with electron microscopy observation. (author)

  12. Creep and Shrinkage of High Strength Concretes: an Experimental Analysis

    Directory of Open Access Journals (Sweden)

    Berenice Martins Toralles carbonari

    2002-01-01

    Full Text Available The creep and shrinkage behaviour of high strength silica fume concretes is significantly different from that of conventional concretes. In order to represent the proper time-dependent response of the material in structural analysis and design, these aspects should be adequately quantified. This paper discusses an experimental setup that is able to determine the creep and shrinkage of concrete from the time of placing. It also compares different gages that can be used for measuring the strains. The method is applied to five different concretes in the laboratory under controlled environmental conditions. The phenomena that are quantified can be classified as basic shrinkage, drying shrinkage, basic creep and drying creep. The relative importance of these mechanisms in high strength concrete will also be presented.

  13. Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis.

    Science.gov (United States)

    Yano, Junko; Noverr, Mairi C; Fidel, Paul L

    2017-03-14

    Despite acute inflammation by polymorphonuclear neutrophils (PMNs) during vulvovaginal candidiasis (VVC), clearance of Candida fails to occur. The purpose of this study was to uncover the mechanism of vaginal PMN dysfunction. Designs included assessing PMN migration, proinflammatory mediators, and tissue damage (by analysis of the activity of lactate dehydrogenase [LDH]) in mice susceptible (C3H/HeN-C57BL/6) or resistant (CD-1) to chronic VVC (CVVC-S or CVVC-R) and testing morphology-specific Candida albicans strains under conditions of preinduced PMN migration (CVVC-S mice) or PMN depletion (CVVC-R mice). In vitro designs included evaluation of C. albicans killing by elicited vaginal or peritoneal PMNs in standard or vaginal conditioned medium (VCM). Results showed that despite significant migration of PMNs and high levels of vaginal beta interleukin-1 (IL-1β) and alarmin S100A8, CVVC-S mice failed to reduce vaginal fungal burden irrespective of morphology or whether PMNs were present pre- or postinoculation, and had high LDH levels. In contrast, CVVC-R mice had reduced fungal burden and low LDH levels following PMN recruitment and IL-1β/S100A8 production, but maintained colonization in the absence of PMNs. Elicited vaginal and peritoneal PMNs showed substantial killing activity in standard media or VCM from CVVC-R mice but not in VCM from CVVC-S mice. The inhibitory effect of VCM from CVVC-S mice was unaffected by endogenous or exogenous estrogen and was ablated following depletion/neutralization of Mac-1 ligands using Mac-1 +/+ PMNs or recombinant Mac-1. Heparan sulfate (HS) was identified as the putative inhibitor as evidenced by the rescue of PMN killing following heparanase treatment of VCM, as well as by inhibition of killing by purified HS. These results suggest that vaginal HS is linked to PMN dysfunction in CVVC-S mice as a competitive ligand for Mac-1. IMPORTANCE Vaginal candidiasis, caused by Candida albicans , affects a significant number of women

  14. Cumulative t-link threshold models for the genetic analysis of calving ease scores

    Directory of Open Access Journals (Sweden)

    Tempelman Robert J

    2003-09-01

    Full Text Available Abstract In this study, a hierarchical threshold mixed model based on a cumulative t-link specification for the analysis of ordinal data or more, specifically, calving ease scores, was developed. The validation of this model and the Markov chain Monte Carlo (MCMC algorithm was carried out on simulated data from normally and t4 (i.e. a t-distribution with four degrees of freedom distributed populations using the deviance information criterion (DIC and a pseudo Bayes factor (PBF measure to validate recently proposed model choice criteria. The simulation study indicated that although inference on the degrees of freedom parameter is possible, MCMC mixing was problematic. Nevertheless, the DIC and PBF were validated to be satisfactory measures of model fit to data. A sire and maternal grandsire cumulative t-link model was applied to a calving ease dataset from 8847 Italian Piemontese first parity dams. The cumulative t-link model was shown to lead to posterior means of direct and maternal heritabilities (0.40 ± 0.06, 0.11 ± 0.04 and a direct maternal genetic correlation (-0.58 ± 0.15 that were not different from the corresponding posterior means of the heritabilities (0.42 ± 0.07, 0.14 ± 0.04 and the genetic correlation (-0.55 ± 0.14 inferred under the conventional cumulative probit link threshold model. Furthermore, the correlation (> 0.99 between posterior means of sire progeny merit from the two models suggested no meaningful rerankings. Nevertheless, the cumulative t-link model was decisively chosen as the better fitting model for this calving ease data using DIC and PBF.

  15. Kinematic and dynamic analysis of a serial-link robot for inspection process in EAST vacuum vessel

    International Nuclear Information System (INIS)

    Peng Xuebing; Yuan Jianjun; Zhang Weijun; Yang Yang; Song Yuntao

    2012-01-01

    Highlights: ► A serial-link robot FIVIR is proposed for inspection of EAST PFCs between plasma shots. ► The FIVIR is a function modular design and has specially designed curvilinear mechanism for axes 4–6. ► The D-H coordinate systems, forward and inverse kinematic model can be easily established and solved for the FIVIR. ► The FIVIR can fulfill the required workspace and has a good dynamic performance in the inspection process. - Abstract: The present paper introduces a serial-link robot which is named flexible in-vessel inspection robot (FIVIR) and developed for Experimental Advanced Superconducting Tokamak (EAST). The task of the robot is to carry process tools, such as viewing camera and leakage detector, to inspect the components installed inside of EAST vacuum vessel. The FIVIR can help to understand the physical phenomena which could be happened in the vacuum vessel during plasma operation and could be one part of EAST remote handling system if needed. The FIVIR was designed with the consideration of having easy control and a good mechanics property which drives it resulted in function modular design. The workspace simulation and kinematic analysis are given in this paper. The dynamic behavior of the FIVIR is studied by multi-body system simulation using ADAMS software. The study result shows the FIVIR has ascendant kinematic and dynamic performance and can fulfill the design requirement for inspection process in EAST vacuum vessel.

  16. Kinematic and dynamic analysis of a serial-link robot for inspection process in EAST vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Peng Xuebing, E-mail: pengxb@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Shushanhu Road 350, Hefei, Anhui 230031 (China); Yuan Jianjun; Zhang Weijun [Research Institute of Robotics, Mechanical Engineering School, Shanghai Jiao Tong University, No.800, Dong Chuan Road, Min Hang District, Shanghai 200240 (China); Yang Yang; Song Yuntao [Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Shushanhu Road 350, Hefei, Anhui 230031 (China)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer A serial-link robot FIVIR is proposed for inspection of EAST PFCs between plasma shots. Black-Right-Pointing-Pointer The FIVIR is a function modular design and has specially designed curvilinear mechanism for axes 4-6. Black-Right-Pointing-Pointer The D-H coordinate systems, forward and inverse kinematic model can be easily established and solved for the FIVIR. Black-Right-Pointing-Pointer The FIVIR can fulfill the required workspace and has a good dynamic performance in the inspection process. - Abstract: The present paper introduces a serial-link robot which is named flexible in-vessel inspection robot (FIVIR) and developed for Experimental Advanced Superconducting Tokamak (EAST). The task of the robot is to carry process tools, such as viewing camera and leakage detector, to inspect the components installed inside of EAST vacuum vessel. The FIVIR can help to understand the physical phenomena which could be happened in the vacuum vessel during plasma operation and could be one part of EAST remote handling system if needed. The FIVIR was designed with the consideration of having easy control and a good mechanics property which drives it resulted in function modular design. The workspace simulation and kinematic analysis are given in this paper. The dynamic behavior of the FIVIR is studied by multi-body system simulation using ADAMS software. The study result shows the FIVIR has ascendant kinematic and dynamic performance and can fulfill the design requirement for inspection process in EAST vacuum vessel.

  17. Analytic analysis of auxetic metamaterials through analogy with rigid link systems

    Science.gov (United States)

    Rayneau-Kirkhope, Daniel; Zhang, Chengzhao; Theran, Louis; Dias, Marcelo A.

    2018-02-01

    In recent years, many structural motifs have been designed with the aim of creating auxetic metamaterials. One area of particular interest in this subject is the creation of auxetic material properties through elastic instability. Such metamaterials switch from conventional behaviour to an auxetic response for loads greater than some threshold value. This paper develops a novel methodology in the analysis of auxetic metamaterials which exhibit elastic instability through analogy with rigid link lattice systems. The results of our analytic approach are confirmed by finite-element simulations for both the onset of elastic instability and post-buckling behaviour including Poisson's ratio. The method gives insight into the relationships between mechanisms within lattices and their mechanical behaviour; as such, it has the potential to allow existing knowledge of rigid link lattices with auxetic paths to be used in the design of future buckling-induced auxetic metamaterials.

  18. Performance Analysis of FSO Links over Unified Gamma-Gamma Turbulence Channels

    KAUST Repository

    Ansari, Imran Shafique

    2015-05-01

    In this work, we present a unified performance analysis of a free-space optical (FSO) link that accounts for pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection as well as heterodyne detection). We, then, present unified exact closed-form expressions for various statistical characteristics of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system. We capitalize on these unified results to offer unified exact closed-form expressions for various performance metrics. Additionally, we derive the asymptotic results for all the expressions derived earlier in the high SNR regime in terms of simple elementary functions. We also derive new asymptotic expressions for the ergodic capacity in the low as well as high SNR regimes in terms of simple elementary functions via utilizing moments. All the presented results are verified via computer-based Monte-Carlo simulations. © 2015 IEEE.

  19. Ergodic Capacity Analysis of Free-Space Optical Links with Nonzero Boresight Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique

    2015-04-01

    A unified capacity analysis of a free-space optical (FSO) link that accounts for nonzero boresight pointing errors and both types of detection techniques (i.e. intensity modulation/ direct detection as well as heterodyne detection) is addressed in this work. More specifically, an exact closed-form expression for the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system is presented in terms of well-known elementary functions. Capitalizing on these new moments expressions, we present approximate and simple closedform results for the ergodic capacity at high and low SNR regimes. All the presented results are verified via computer-based Monte-Carlo simulations.

  20. Short Circuit Ratio analysis of multi-infeed HVDC system with a VSC-HVDC link

    DEFF Research Database (Denmark)

    Liu, Yan; Chen, Zhe

    2011-01-01

    As an important indicator of system stability, Short Circuit Ratio (SCR) is commonly used in power system analysis. For systems include HVDC link connection, the Effective SCR (ESCR) is mostly applied to indicate the strength of HVDC infeed bus. The contribution of VSC-HVDC link to multi......-infeed HVDC system stability has been analyzed a lot but the study on ESCR of this kind of system is still insufficient. This paper presents a calculation method for ESCR of the hybrid multi infeed HVDC system based on a simple two-infeed HVDC system model. The equivalent circuit of this system under short...... circuit situation is firstly obtained based on the model. Then its Thevenin equivalent circuit is derived and system ESCR can be calculated. At last, simulation study verified that the calculated ESCR value under different cases can indicate the change of system stability....

  1. Experimental Tritium Cleanup System availability analysis from 1984 to 1992

    International Nuclear Information System (INIS)

    Cadwallader, L.C.; Taylor, G.L.

    1993-05-01

    This report gives the availability percentage of the Experimental Tritium Cleanup System (ETC) at the Tritium Systems Test Assembly (TSTA), which is a fusion research and technology facility at the Los Alamos National Laboratory. The component failure reports, the numbers of components, and operating times or demands are all given in this report. Sample calculations of the failure rates obtained from these data are given in the appendices. While future fusion experiments might use different or more advanced means to detritiate room air, the analysis of this system gives a data point for an actual detritiation system. Such a data point can be extrapolated for comparison with fault tree results on system designs, or can be used in a Bayesian failure rate analysis for estimating reliability of a new type of system. The nine years of testing operations on TSTA's ETC result in a reasonable average availability value of 92% for the maximal tritium release event. The failure rates for new systems are expected to be lower than for the TSTA ETC, since improvements will be made in the design of the room air detritiation system based on the TSTA system experiences. Nonetheless, these TSTA data should be useful for future fusion reactor design work and safety assessment tasks

  2. Acoustic analysis in Mudejar-Gothic churches: experimental results.

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria.

  3. Acoustic analysis in Mudejar-Gothic churches: Experimental results

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria. .

  4. Optical bandgap of semiconductor nanostructures: Methods for experimental data analysis

    Science.gov (United States)

    Raciti, R.; Bahariqushchi, R.; Summonte, C.; Aydinli, A.; Terrasi, A.; Mirabella, S.

    2017-06-01

    Determination of the optical bandgap (Eg) in semiconductor nanostructures is a key issue in understanding the extent of quantum confinement effects (QCE) on electronic properties and it usually involves some analytical approximation in experimental data reduction and modeling of the light absorption processes. Here, we compare some of the analytical procedures frequently used to evaluate the optical bandgap from reflectance (R) and transmittance (T) spectra. Ge quantum wells and quantum dots embedded in SiO2 were produced by plasma enhanced chemical vapor deposition, and light absorption was characterized by UV-Vis/NIR spectrophotometry. R&T elaboration to extract the absorption spectra was conducted by two approximated methods (single or double pass approximation, single pass analysis, and double pass analysis, respectively) followed by Eg evaluation through linear fit of Tauc or Cody plots. Direct fitting of R&T spectra through a Tauc-Lorentz oscillator model is used as comparison. Methods and data are discussed also in terms of the light absorption process in the presence of QCE. The reported data show that, despite the approximation, the DPA approach joined with Tauc plot gives reliable results, with clear advantages in terms of computational efforts and understanding of QCE.

  5. Improving Our Ability to Assess Land Management and Disturbance by Linking Traditional Ecosystem Measurements with UAV Spectral Analysis

    Science.gov (United States)

    Sutter, L., Jr.; Barron-Gafford, G.; Smith, W. K.; Minor, R. L.; Raub, H.; Jimenez, J. R.; Wolsiffer, S. K.; Escobedo, E. B.; Smith, J.

    2017-12-01

    Drylands are dynamic landscapes of mixed plant functional types that vary in their response to abiotic and biotic drivers of change. Within these regions, woody plant-herbaceous relationships have generally been viewed as negative: woody plants within these ecosystems have been shown to negatively impact herbaceous growth by taking advantage of both deeper stored water and intercepting near surface moisture after precipitation events. There has been a long-invested effort to eliminate woody plants in many areas of the world, and analyzing and assessing land management decisions has historically required high monetary and time inputs. Unfortunately, both management practices and disturbances from fire can leave a very heterogeneous landscape, making assessment of their impacts difficult to assess. This study has attempted to address the effectiveness of two commonly used treatments within woody plant invaded areas, fire and herbicide application, by linking plant physiological measurements with the emerging technology of unmanned aerial vehicle (UAV) spectral analysis. Taking advantage of a USDA-ARS sponsored herbicide treatment in 2016 and the accidental Sawmill Fire of 2017, both within the Santa Rita Experimental Range (SRER) of Southern Arizona, USA, we linked spectral data collected via UAV with ground-based photosynthetic measurements. Given the high repeatability, and both spatial and spectral resolution of low-flying UAV measurements, we found that there are a variety of spectral indices that can be derived and accurately linked with traditional ecological measurements. Results and techniques from this study can be immediately applied to land management plans as well as be improved for other ecological parameters, such as those obtained from long-term study sites containing eddy covariance towers.

  6. Fatigue behavior of a bolted assembly - a comparison between numerical analysis and experimental analysis

    International Nuclear Information System (INIS)

    Bosser, M.; Vagner, J.

    1987-01-01

    The fatigue behavior of a bolted assembly can be analysed, either by fatigue tests, or by computing the stress variations and using a fatigue curve. This paper presents the fatigue analysis of a stud-bolt and stud-flange of a steam generator manway carried out with the two methods. The experimental analysis is performed for various levels of load, according to the recommandations of the ASME code section III appendix II. The numerical analysis of the stresses is based on the results of a finite element analysis performed with the program SYSTUS. The maximum stresses are obtained in the first bolt threads. In using these stresses, the allowable number of cycles for each level of loading analysed, is obtained from fatigue curves, as defined in appendix I section III of the ASME code. The analysis underlines that, for each level of load the purely numerical approach is highly conservative, compared to the experimental approach. (orig.)

  7. Linkage and candidate gene analysis of X-linked familial exudative vitreoretinopathy.

    Science.gov (United States)

    Shastry, B S; Hejtmancik, J F; Plager, D A; Hartzer, M K; Trese, M T

    1995-05-20

    Familial exudative vitreoretinopathy (FEVR) is a hereditary eye disorder characterized by avascularity of the peripheral retina, retinal exudates, tractional detachment, and retinal folds. The disorder is most commonly transmitted as an autosomal dominant trait, but X-linked transmission also occurs. To initiate the process of identifying the gene responsible for the X-linked disorder, linkage analysis has been performed with three previously unreported three- or four-generation families. Two-point analysis showed linkage to MAOA (Zmax = 2.1, theta max = 0) and DXS228 (Zmax = 0.5, theta max = 0.11), and this was further confirmed by multipoint analysis with these same markers (Zmax = 2.81 at MAOA), which both lie near the gene causing Norrie disease. Molecular genetic analysis further reveals a missense mutation (R121W) in the third exon of the Norrie's disease gene that perfectly cosegregates with the disease through three generations in one family. This mutation was not detected in the unaffected family members and six normal unrelated controls, suggesting that it is likely to be the pathogenic mutation. Additionally, a polymorphic missense mutation (H127R) was detected in a severely affected patient.

  8. Multivariate Analysis for Animal Selection in Experimental Research

    Directory of Open Access Journals (Sweden)

    Renan Mercuri Pinto

    2015-02-01

    Full Text Available Background: Several researchers seek methods for the selection of homogeneous groups of animals in experimental studies, a fact justified because homogeneity is an indispensable prerequisite for casualization of treatments. The lack of robust methods that comply with statistical and biological principles is the reason why researchers use empirical or subjective methods, influencing their results. Objective: To develop a multivariate statistical model for the selection of a homogeneous group of animals for experimental research and to elaborate a computational package to use it. Methods: The set of echocardiographic data of 115 male Wistar rats with supravalvular aortic stenosis (AoS was used as an example of model development. Initially, the data were standardized, and became dimensionless. Then, the variance matrix of the set was submitted to principal components analysis (PCA, aiming at reducing the parametric space and at retaining the relevant variability. That technique established a new Cartesian system into which the animals were allocated, and finally the confidence region (ellipsoid was built for the profile of the animals’ homogeneous responses. The animals located inside the ellipsoid were considered as belonging to the homogeneous batch; those outside the ellipsoid were considered spurious. Results: The PCA established eight descriptive axes that represented the accumulated variance of the data set in 88.71%. The allocation of the animals in the new system and the construction of the confidence region revealed six spurious animals as compared to the homogeneous batch of 109 animals. Conclusion: The biometric criterion presented proved to be effective, because it considers the animal as a whole, analyzing jointly all parameters measured, in addition to having a small discard rate.

  9. The alliance relationship analysis of international terrorist organizations with link prediction

    Science.gov (United States)

    Fang, Ling; Fang, Haiyang; Tian, Yanfang; Yang, Tinghong; Zhao, Jing

    2017-09-01

    Terrorism is a huge public hazard of the international community. Alliances of terrorist organizations may cause more serious threat to national security and world peace. Understanding alliances between global terrorist organizations will facilitate more effective anti-terrorism collaboration between governments. Based on publicly available data, this study constructed a alliance network between terrorist organizations and analyzed the alliance relationships with link prediction. We proposed a novel index based on optimal weighted fusion of six similarity indices, in which the optimal weight is calculated by genetic algorithm. Our experimental results showed that this algorithm could achieve better results on the networks than other algorithms. Using this method, we successfully digged out 21 real terrorist organizations alliance from current data. Our experiment shows that this approach used for terrorist organizations alliance mining is effective and this study is expected to benefit the form of a more powerful anti-terrorism strategy.

  10. The Profitability of the Strategy Linking Fundamental, Portfolio and Technical Analysis on the Polish Capital Market

    Directory of Open Access Journals (Sweden)

    Flotyński Marcin

    2016-12-01

    Full Text Available In the article, several methods of taking investment decisions are described: a fundamental, portfolio, and technical analysis. They constitute different approaches which are convenient for different types of investors with various expectations and time horizons of their investments. The simultaneous combination of these three analyses is not popular. The aim of this study is to test the effectiveness of simultaneous use of a fundamental analysis, portfolio analysis, and technical analysis for shares quoted on the Warsaw Stock Exchange (WSE in 2000–2007. The research hypothesis is advanced that the concurrent-linked application of a fundamental, portfolio, and technical analysis brings better results than the separate use of these analyses. Models of capital market, such as CAPM and APT, have been used, as well as P/E ratio, Return on Equity (RoE, Relative Strength Index (RSI, and Exponential Moving Average (EMA. The combination of a financial analysis, technical indicators, and models of the capital market in order to invest on the stock exchange is author’s own method. In general, the survey has been carried out on the grounds of quantitative methods (financial analysis, regression model, and multi regression model and a comparative analysis. The results of the research have been used to create diversified portfolios on the WSE. It occurs that the concurrent use of the three analyses brings the highest rate of return of a portfolio.

  11. Simulink models for performance analysis of high speed DQPSK modulated optical link

    International Nuclear Information System (INIS)

    Sharan, Lucky; Rupanshi,; Chaubey, V. K.

    2016-01-01

    This paper attempts to present the design approach for development of simulation models to study and analyze the transmission of 10 Gbps DQPSK signal over a single channel Peer to Peer link using Matlab Simulink. The simulation model considers the different optical components used in link design with their behavior represented initially by theoretical interpretation, including the transmitter topology, Mach Zehnder Modulator(MZM) module and, the propagation model for optical fibers etc. thus allowing scope for direct realization in experimental configurations. It provides the flexibility to incorporate the various photonic components as either user-defined or fixed and, can also be enhanced or removed from the model as per the design requirements. We describe the detailed operation and need of every component model and its representation in Simulink blocksets. Moreover the developed model can be extended in future to support Dense Wavelength Division Multiplexing (DWDM) system, thereby allowing high speed transmission with N × 40 Gbps systems. The various compensation techniques and their influence on system performance can be easily investigated by using such models.

  12. Simulink models for performance analysis of high speed DQPSK modulated optical link

    Energy Technology Data Exchange (ETDEWEB)

    Sharan, Lucky, E-mail: luckysharan@pilani.bits-pilani.ac.in; Rupanshi,, E-mail: f2011222@pilani.bits-pilani.ac.in; Chaubey, V. K., E-mail: vkc@pilani.bits-pilani.ac.in [EEE Department, BITS-Pilani, Rajasthan, 333031 (India)

    2016-03-09

    This paper attempts to present the design approach for development of simulation models to study and analyze the transmission of 10 Gbps DQPSK signal over a single channel Peer to Peer link using Matlab Simulink. The simulation model considers the different optical components used in link design with their behavior represented initially by theoretical interpretation, including the transmitter topology, Mach Zehnder Modulator(MZM) module and, the propagation model for optical fibers etc. thus allowing scope for direct realization in experimental configurations. It provides the flexibility to incorporate the various photonic components as either user-defined or fixed and, can also be enhanced or removed from the model as per the design requirements. We describe the detailed operation and need of every component model and its representation in Simulink blocksets. Moreover the developed model can be extended in future to support Dense Wavelength Division Multiplexing (DWDM) system, thereby allowing high speed transmission with N × 40 Gbps systems. The various compensation techniques and their influence on system performance can be easily investigated by using such models.

  13. Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, Oliver; Keranen, Soile V.E.; Biggin, Mark; Knowles, David W.; Weber, Gunther H.; Hagen, Hans; Hamann, Bernd; Bethel, E. Wes

    2011-03-30

    Three-dimensional gene expression PointCloud data generated by the Berkeley Drosophila Transcription Network Project (BDTNP) provides quantitative information about the spatial and temporal expression of genes in early Drosophila embryos at cellular resolution. The BDTNP team visualizes and analyzes Point-Cloud data using the software application PointCloudXplore (PCX). To maximize the impact of novel, complex data sets, such as PointClouds, the data needs to be accessible to biologists and comprehensible to developers of analysis functions. We address this challenge by linking PCX and Matlab via a dedicated interface, thereby providing biologists seamless access to advanced data analysis functions and giving bioinformatics researchers the opportunity to integrate their analysis directly into the visualization application. To demonstrate the usefulness of this approach, we computationally model parts of the expression pattern of the gene even skipped using a genetic algorithm implemented in Matlab and integrated into PCX via our Matlab interface.

  14. The Finance Growth Link: Comparative Analysis of Two Eastern African Countries

    Directory of Open Access Journals (Sweden)

    Fanta Ashenafi Beyene

    2016-09-01

    Full Text Available This paper examines the finance growth link of two low-income Sub-Saharan African economies – Ethiopia and Kenya – which have different financial systems but are located in the same region. Unlike previous studies, we account for the role of non-bank financial intermediaries and formally model the effect of structural breaks caused by policy and market-induced economic events. We used the Vector Autoregressive model (VAR, conducted impulse response analysis and examined variance decomposition. We find that neither the level of financial intermediary development nor the level of stock market development explains economic growth in Kenya. For Ethiopia, which has no stock market, intermediary development is found to be driven by economic growth. Three important inferences can be made from these findings. First, the often reported positive link between finance and growth might be caused by the aggregation of countries at different stages of economic growth and financial development. Second, country-specific economic situations and episodes are important in studying the relationship between financial development and economic growth. Third, there is the possibility that the econometric model employed to test the finance growth link plays a role in the empirical result, as we note that prior studies did not introduce control variables.

  15. Modeling and Performance Analysis of 10 Gbps Inter-satellite Optical Wireless Communication Link

    Science.gov (United States)

    Singh, Mehtab

    2017-12-01

    Free-space optical (FSO) communication has the advantages of two of the most predominant data transmission technologies - optical fiber communication and wireless communication. Most of the technical aspects of FSO are similar to that of optical fiber communication, with major difference in the information signal propagation medium which is free space in case of FSO rather than silica glass in optical fiber communication. One of the most important applications of FSO is inter-satellite optical wireless communication (IsOWC) links which will be deployed in the future in space. The IsOWC links have many advantages over the previously existing microwave satellite communication technologies such as higher bandwidth, lower power consumption, low cost of implementation, light size, and weight. In this paper, modeling and performance analysis of a 10-Gbps inter-satellite communication link with two satellites separated at a distance of 1,200 km has been done using OPTISYSTEM simulation software. Performance has been analyzed on the basis of quality factor, signal to noise ratio (SNR), and total power of the received signal.

  16. Identification of genetic markers linked to anthracnose resistance in sorghum using association analysis.

    Science.gov (United States)

    Upadhyaya, Hari D; Wang, Yi-Hong; Sharma, Rajan; Sharma, Shivali

    2013-06-01

    Anthracnose in sorghum caused by Colletotrichum sublineolum is one of the most destructive diseases affecting sorghum production under warm and humid conditions. Markers and genes linked to resistance to the disease are important for plant breeding. Using 14,739 SNP markers, we have mapped eight loci linked to resistance in sorghum through association analysis of a sorghum mini-core collection consisting of 242 diverse accessions evaluated for anthracnose resistance for 2 years in the field. The mini-core was representative of the International Crops Research Institute for the Semi-Arid Tropics' world-wide sorghum landrace collection. Eight marker loci were associated with anthracnose resistance in both years. Except locus 8, disease resistance-related genes were found in all loci based on their physical distance from linked SNP markers. These include two NB-ARC class of R genes on chromosome 10 that were partially homologous to the rice blast resistance gene Pib, two hypersensitive response-related genes: autophagy-related protein 3 on chromosome 1 and 4 harpin-induced 1 (Hin1) homologs on chromosome 8, a RAV transcription factor that is also part of R gene pathway, an oxysterol-binding protein that functions in the non-specific host resistance, and homologs of menthone:neomenthol reductase (MNR) that catalyzes a menthone reduction to produce the antimicrobial neomenthol. These genes and markers may be developed into molecular tools for genetic improvement of anthracnose resistance in sorghum.

  17. A multilayer network analysis of hashtags in twitter via co-occurrence and semantic links

    Science.gov (United States)

    Türker, Ilker; Sulak, Eyüb Ekmel

    2018-02-01

    Complex network studies, as an interdisciplinary framework, span a large variety of subjects including social media. In social networks, several mechanisms generate miscellaneous structures like friendship networks, mention networks, tag networks, etc. Focusing on tag networks (namely, hashtags in twitter), we made a two-layer analysis of tag networks from a massive dataset of Twitter entries. The first layer is constructed by converting the co-occurrences of these tags in a single entry (tweet) into links, while the second layer is constructed converting the semantic relations of the tags into links. We observed that the universal properties of the real networks like small-world property, clustering and power-law distributions in various network parameters are also evident in the multilayer network of hashtags. Moreover, we outlined that co-occurrences of hashtags in tweets are mostly coupled with semantic relations, whereas a small number of semantically unrelated, therefore random links reduce node separation and network diameter in the co-occurrence network layer. Together with the degree distributions, the power-law consistencies of degree difference, edge weight and cosine similarity distributions in both layers are also appealing forms of Zipf’s law evident in nature.

  18. Experimental and mathematical model of the interactions in the mixed culture of links in the “producer-consumer” cycle

    Science.gov (United States)

    Pisman, T. I.

    2009-07-01

    The paper presents a experimental and mathematical model of interactions between invertebrates (the ciliates Paramecium caudatum and the rotifers Brachionus plicatilis) in the "producer-consumer" aquatic biotic cycle with spatially separated components. The model describes the dynamics of the mixed culture of ciliates and rotifers in the "consumer" component, feeding on the mixed algal culture of the "producer" component. It has been found that metabolites of the algae Scenedesmus produce an adverse effect on the reproduction of the ciliates P. caudatum. Taking into account this effect, the results of investigation of the mathematical model were in qualitative agreement with the experimental results. In the "producer-consumer" biotic cycle it was shown that coexistence is impossible in the mixed culture of invertebrates of the "consumer" component. The ciliates P. caudatum are driven out by the rotifers B. plicatilis.

  19. Experimental and mathematical model of the interactions in the mixed culture of links in the "producer-consumer" cycle

    Science.gov (United States)

    Pisman, T. I.; Galayda, Ya. V.

    The paper presents experimental and mathematical model of interactions between invertebrates the ciliates Paramecium caudatum and the rotifers Brachionus plicatilis and algae Chlorella vulgaris and Scenedesmus quadricauda in the producer -- consumer aquatic biotic cycle with spatially separated components The model describes the dynamics of the mixed culture of ciliates and rotifers in the consumer component feeding on the mixed algal culture of the producer component It has been found that metabolites of the algae Scenedesmus produce an adverse effect on the reproduction of the ciliates P caudatum Taking into account this effect the results of investigation of the mathematical model were in qualitative agreement with the experimental results In the producer -- consumer biotic cycle it was shown that coexistence is impossible in the mixed algal culture of the producer component and in the mixed culture of invertebrates of the consumer component The ciliates P caudatum are driven out by the rotifers Brachionus plicatilis

  20. A didactical structural model – linking analysis of teaching and analysis of educational media

    DEFF Research Database (Denmark)

    Graf, Stefan Ting

    1. Gap between general didactics and textbook/media research There seems to be a gap between general didactics (theory of teaching) and research in textbooks or educational media in general at least in the Nordic and German speaking countries. General didactic and their models seem to underestimate...... related questions (e.g. readability) without establishing a link to what is useful for the teacher’s tasks both on the level of preparation, practice and reflection, i.e. without an explicit theory of teaching. 2. Media in general didactics I will discuss the status of media in some current models...... of reflection in general didactics (Hiim/Hippe, Meyer, Klafki) and present a reconstruction of a didactical model of structure (Strukturmodel), whose counterstones are ‘intentional content’, ‘media/expression’ and ‘teaching method/activity’. The inclusion of media/expression in the model resumes a seemingly...

  1. Characterization of Disulfide-Linked Peptides Using Tandem Mass Spectrometry Coupled with Automated Data Analysis Software

    Science.gov (United States)

    Liang, Zhidan; McGuinness, Kenneth N.; Crespo, Alejandro; Zhong, Wendy

    2018-05-01

    Disulfide bond formation is critical for maintaining structure stability and function of many peptides and proteins. Mass spectrometry has become an important tool for the elucidation of molecular connectivity. However, the interpretation of the tandem mass spectral data of disulfide-linked peptides has been a major challenge due to the lack of appropriate tools. Developing proper data analysis software is essential to quickly characterize disulfide-linked peptides. A thorough and in-depth understanding of how disulfide-linked peptides fragment in mass spectrometer is a key in developing software to interpret the tandem mass spectra of these peptides. Two model peptides with inter- and intra-chain disulfide linkages were used to study fragmentation behavior in both collisional-activated dissociation (CAD) and electron-based dissociation (ExD) experiments. Fragments generated from CAD and ExD can be categorized into three major types, which result from different S-S and C-S bond cleavage patterns. DiSulFinder is a computer algorithm that was newly developed based on the fragmentation observed in these peptides. The software is vendor neutral and capable of quickly and accurately identifying a variety of fragments generated from disulfide-linked peptides. DiSulFinder identifies peptide backbone fragments with S-S and C-S bond cleavages and, more importantly, can also identify fragments with the S-S bond still intact to aid disulfide linkage determination. With the assistance of this software, more comprehensive disulfide connectivity characterization can be achieved. [Figure not available: see fulltext.

  2. Characterization of Disulfide-Linked Peptides Using Tandem Mass Spectrometry Coupled with Automated Data Analysis Software.

    Science.gov (United States)

    Liang, Zhidan; McGuinness, Kenneth N; Crespo, Alejandro; Zhong, Wendy

    2018-01-25

    Disulfide bond formation is critical for maintaining structure stability and function of many peptides and proteins. Mass spectrometry has become an important tool for the elucidation of molecular connectivity. However, the interpretation of the tandem mass spectral data of disulfide-linked peptides has been a major challenge due to the lack of appropriate tools. Developing proper data analysis software is essential to quickly characterize disulfide-linked peptides. A thorough and in-depth understanding of how disulfide-linked peptides fragment in mass spectrometer is a key in developing software to interpret the tandem mass spectra of these peptides. Two model peptides with inter- and intra-chain disulfide linkages were used to study fragmentation behavior in both collisional-activated dissociation (CAD) and electron-based dissociation (ExD) experiments. Fragments generated from CAD and ExD can be categorized into three major types, which result from different S-S and C-S bond cleavage patterns. DiSulFinder is a computer algorithm that was newly developed based on the fragmentation observed in these peptides. The software is vendor neutral and capable of quickly and accurately identifying a variety of fragments generated from disulfide-linked peptides. DiSulFinder identifies peptide backbone fragments with S-S and C-S bond cleavages and, more importantly, can also identify fragments with the S-S bond still intact to aid disulfide linkage determination. With the assistance of this software, more comprehensive disulfide connectivity characterization can be achieved. Graphical Abstract ᅟ.

  3. Experimental characterization of a 400  Gbit/s orbital angular momentum multiplexed free-space optical link over 120 m

    OpenAIRE

    Ren, Yongxiong; Wang, Zhe; Liao, Peicheng; Li, Long; Xie, Guodong; Huang, Hao; Zhao, Zhe; Yan, Yan; Ahmed, Nisar; Willner, Asher; Lavery, Martin P.J.; Ashrafi, Nima; Ashrafi, Solyman; Bock, Robert; Tur, Moshe

    2016-01-01

    We experimentally demonstrate and characterize the\\ud performance of a 400-Gbit/s orbital angular momentum\\ud (OAM) multiplexed free-space optical link over 120-\\ud meters on the roof of a building. Four OAM beams, each\\ud carrying a 100-Gbit/s QPSK channel are multiplexed and\\ud transmitted. We investigate the influence of channel\\ud impairments on the received power, inter-modal\\ud crosstalk among channels, and system power penalties.\\ud Without laser tracking and compensation systems, the\\...

  4. Reactor noise analysis of experimental fast reactor 'JOYO'

    International Nuclear Information System (INIS)

    Ohtani, Hideji; Yamamoto, Hisashi

    1980-01-01

    As a part of dynamics tests in experimental fast reactor ''JOYO'', reactor noise tests were carried out. The reactor noise analysis techniques are effective for study of plant characteristics by determining fluctuations of process signals (neutron signal, reactor inlet temperature signals, etc.), which are able to be measured without disturbances for reactor operations. The aims of reactor noise tests were to confirm that no unstable phenomenon exists in ''JOYO'' and to gain initial data of the plant for reference of the future data. Data for the reactor noise tests treated in this paper were obtained at 50 MW power level. Fluctuations of process signals were amplified and recorded on analogue tapes. The analysis was performed using noise code (NOISA) of digital computer, with which statistical values of ASPD (auto power spectral density), CPSD (cross power spectral density), and CF (coherence function) were calculated. The primary points of the results are as follows. 1. RMS value of neutron signal at 50 MW power level is about 0.03 MW. This neutron fluctuation is not disturbing reactor operations. 2. The fluctuations of A loop reactor inlet temperatures (T sub(AI)) are larger than the fluctuations of B loop reactor inlet temperature (T sub(BI)). For this reason, the major driving force of neutron fluctuations seems to be the fluctuations of T sub(AI). 3. Core and blanket subassemblies can be divided into two halves (A and B region), with respect to the spacial motion of temperature in the reactor core. A or B region means the region in which sodium temperature fluctuations in subassembly are significantly affected by T sub(AI) or T sub(BI), respectively. This phenomenon seems to be due to the lack of mixing of A and B loop sodium in lower plenum of reactor vessel. (author)

  5. Station Blackout Analysis of HTGR-Type Experimental Power Reactor

    Science.gov (United States)

    Syarip; Zuhdi, Aliq; Falah, Sabilul

    2018-01-01

    The National Nuclear Energy Agency of Indonesia has decided to build an experimental power reactor of high-temperature gas-cooled reactor (HTGR) type located at Puspiptek Complex. The purpose of this project is to demonstrate a small modular nuclear power plant that can be operated safely. One of the reactor safety characteristics is the reliability of the reactor to the station blackout (SBO) event. The event was observed due to relatively high disturbance frequency of electricity network in Indonesia. The PCTRAN-HTR functional simulator code was used to observe fuel and coolant temperature, and coolant pressure during the SBO event. The reactor simulated at 10 MW for 7200 s then the SBO occurred for 1-3 minutes. The analysis result shows that the reactor power decreases automatically as the temperature increase during SBO accident without operator’s active action. The fuel temperature increased by 36.57 °C every minute during SBO and the power decreased by 0.069 MW every °C fuel temperature rise at the condition of anticipated transient without reactor scram. Whilst, the maximum coolant (helium) temperature and pressure are 1004 °C and 9.2 MPa respectively. The maximum fuel temperature is 1282 °C, this value still far below the fuel temperature limiting condition i.e. 1600 °C, its mean that the HTGR has a very good inherent safety system.

  6. Homologous Recombination—Experimental Systems, Analysis and Significance

    Science.gov (United States)

    Kuzminov, Andrei

    2014-01-01

    Homologous recombination is the most complex of all recombination events that shape genomes and produce material for evolution. Homologous recombination events are exchanges between DNA molecules in the lengthy regions of shared identity, catalyzed by a group of dedicated enzymes. There is a variety of experimental systems in E. coli and Salmonella to detect homologous recombination events of several different kinds. Genetic analysis of homologous recombination reveals three separate phases of this process: pre-synapsis (the early phase), synapsis (homologous strand exchange) and post-synapsis (the late phase). In E. coli, there are at least two independent pathway of the early phase and at least two independent pathways of the late phase. All this complexity is incongruent with the originally ascribed role of homologous recombination as accelerator of genome evolution: there is simply not enough duplication and repetition in enterobacterial genomes for homologous recombination to have a detectable evolutionary role, and therefore not enough selection to maintain such a complexity. At the same time, the mechanisms of homologous recombination are uniquely suited for repair of complex DNA lesions called chromosomal lesions. In fact, the two major classes of chromosomal lesions are recognized and processed by the two individual pathways at the early phase of homologous recombination. It follows, therefore, that homologous recombination events are occasional reflections of the continual recombinational repair, made possible in cases of natural or artificial genome redundancy. PMID:26442506

  7. Experimental programme and analysis, ZENITH II, Core 4

    Energy Technology Data Exchange (ETDEWEB)

    Ingram, G.; Sanders, J. E.; Sherwin, J.

    1974-10-15

    The Phase 3 program of reactor physics experiments on the HTR (or Mk 3 GCR) lattices continued during the first half of 1974 with a study of a series of critical builds in Zenith II aimed at testing predictions of shut-down margins in the local criticality-situations arising during power reactor refueling. The paper describes the experimental program and the subsequent theoretical analysis using methods developed in the United Kingdom for calculating low-enriched uranium HTR fuel systems. The importance of improving the accuracy of predictions of shut-down margins arises from the basic requirement that the core in its most reactive condition and with a specified number of absorbers removed from the array must remain sub-critical with a margin adequate to cover the total uncertainty of +/- 1 Nile (that is, 1 % delta-k). The major uncertainty is that in modelling the complex fuel/absorber configuration, and this is the aspect essentially covered in the Zenith II Core 4 studies.

  8. Experimental analysis of a new retarding field energy analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Yu-Xiang [Shanghai Institute of Mechanical and Electrical Engineering, No. 3888, Yuanjiang Road, Minhang District, Shanghai 201109 (China); Institute of Electronics, Chinese Academy of Sciences, No. 19, North 4th Ring Road West, Haidian District, Beijing 100190 (China); Liu, Shu-Qing; Li, Xian-Xia; Shen, Hong-Li; Huang, Ming-Guang [Institute of Electronics, Chinese Academy of Sciences, No. 19, North 4th Ring Road West, Haidian District, Beijing 100190 (China); Liu, Pu-Kun, E-mail: pkliu@pku.edu.cn [School of Electronics Engineering and Computer Science, Peking University, No. 5, Yiheyuan Road, Haidian District, Beijing 100871 (China)

    2015-06-11

    In this paper, a new compact retarding field energy analyzer (RFEA) is designed for diagnosing electron beams of a K-band space travelling-wave tube (TWT). This analyzer has an aperture plate to sample electron beams and a cylindrical electrode to overcome the defocusing effects. The front end of the analyzer constructed as a multistage depression collector (MDC) structure is intended to shape the field to prevent electrons from being accelerated to escape. The direct-current (DC) beams of the K-band space TWTs with the removing MDC can be investigated on the beam measurement system. The current density distribution of DC beams is determined by the analyzer, while the anode voltage and helix voltage of the TWTs are 7000 V and 6850 V, respectively. The current curve’s slope effect due to the reflection of secondary electrons on the copper collector of the analyzer is discussed. The experimental analysis shows this RFEA has a good energy resolution to satisfy the requirement of beam measurement. - Highlights: • A new retarding field energy analyzer (RFEA) is designed to diagnose the electron beam of a K-band space TWT. • The current density distribution of direct-current beam is determined. • The reflection effect of secondary electrons on the copper collector of the analyzer is discussed.

  9. Development of an experimental apparatus for nucleate boiling analysis

    International Nuclear Information System (INIS)

    Castro, A.J.A. de.

    1984-01-01

    An experimental apparatus is developed for the study of the parameters that affect nucleate boiling. The experimental set up is tested for nucleate boiling in an annular test section with subcooled water flow. The following parameters are analysed: pressure, fluid velocity and the fluid temperature at the test section entrance. The performance of the experimental apparatus is analysed by the results and by the problems raised by the operation of the setup. (Author) [pt

  10. The Glasgow 'Deep End' Links Worker Study Protocol: a quasi-experimental evaluation of a social prescribing intervention for patients with complex needs in areas of high socioeconomic deprivation.

    Science.gov (United States)

    Mercer, Stewart W; Fitzpatrick, Bridie; Grant, Lesley; Chng, Nai Rui; O'Donnell, Catherine A; Mackenzie, Mhairi; McConnachie, Alex; Bakhshi, Andisheh; Wyke, Sally

    2017-01-01

    'Social prescribing' can be used to link patients with complex needs to local (non-medical) community resources. The 'Deep End' Links Worker Programme is being tested in general practices serving deprived populations in Glasgow, Scotland. To assess the implementation and impact of the intervention at patient and practice levels. Study design : Quasi-experimental outcome evaluation with embedded theory-driven process evaluation in 15 practices randomized to receive the intervention or not. Complex intervention : Comprising a practice development fund, a practice-based community links practitioner (CLP), and management support. It aims to link patients to local community organizations and enhance practices' social prescribing capacity. Study population : For intervention practices, staff and adult patients involved in referral to a CLP, and a sample of community organization staff. For comparison practices, all staff and a random sample of adult patients. Sample size : 286 intervention and 484 comparator patients. Outcomes : Primary patient outcome is health-related quality of life (EQ-5D-5L). Secondary patient outcomes include capacity, depression/anxiety, self-esteem, and healthcare utilization. Practice outcome measures include team climate, job satisfaction, morale, and burnout. Outcomes measured at baseline and 9 months. Processes : Barriers and facilitators to implementation of the programme and possible mechanisms through which outcomes are achieved. Analysis plan : For outcome, intention-to-treat analysis with differences between groups tested using mixed-effects regression models. For process, case-study approach with thematic analysis. This evaluation will provide new evidence about the implementation and impact of social prescribing by general practices serving patients with complex needs living in areas of high deprivation.

  11. Analysis of Return and Forward Links from STARS' Flight Demonstration 1

    Science.gov (United States)

    Gering, James A.

    2003-01-01

    Space-based Telemetry And Range Safety (STARS) is a Kennedy Space Center (KSC) led proof-of-concept demonstration, which utilizes NASA's space network of Tracking and Data Relay Satellites (TDRS) as a pathway for launch and mission related information streams. Flight Demonstration 1 concluded on July 15,2003 with the seventh flight of a Low Power Transmitter (LPT) a Command and Data Handler (C&DH), a twelve channel GPS receiver and associated power supplies and amplifiers. The equipment flew on NASA's F-I5 aircraft at the Dryden Flight Research Center located at Edwards Air Force Base in California. During this NASA-ASEE Faculty Fellowship, the author participated in the collection and analysis of data from the seven flights comprising Flight Demonstration 1. Specifically, the author examined the forward and return links bit energy E(sub B) (in Watt-seconds) divided by the ambient radio frequency noise N(sub 0) (in Watts / Hertz). E(sub b)/N(sub 0) is commonly thought of as a signal-to-noise parameter, which characterizes a particular received radio frequency (RF) link. Outputs from the data analysis include the construction of time lines for all flights, production of graphs of range safety values for all seven flights, histograms of range safety E(sub b)/N(sub 0) values in five dB increments, calculation of associated averages and standard deviations, production of graphs of range user E(sub b)/N(sub 0) values for the all flights, production of graphs of AGC's and E(sub b)/N(sub 0) estimates for flight 1, recorded onboard, transmitted directly to the launch head and transmitted through TDRS. The data and graphs are being used to draw conclusions related to a lower than expected signal strength seen in the range safety return link.

  12. Evaluation of thermal ratchetting on axisymmetric thin shells at the free level of sodium: Experimental results and elastic analysis

    International Nuclear Information System (INIS)

    Cabrillat, M.T.; Gatt, J.M.; Schoulguine, P.; Skiara, A.

    1993-01-01

    Startup operations and load variations for a FBR reactor (Fast Breeder Reactor) cause sodium level variations in the vessels which exert stresses on the emergent shells in the free level area. The loading of these shells is mainly linked to the axial thermal gradient, primary stresses being generally low or negligible as are the radial thermal gradients. Under the effect of these variable axial thermal gradients, there is a risk of progressive deformation even in the absence of primary type stresses. The simplified methods of analysis (Bree diagram, efficiency diagram) proposed in the design codes (Code Case and RCCMR) are not applicable in this specific case where primary type stresses are negligible. In recent years, many studies and experimental programmes have been undertaken in order to propose more reliable methods of analysis for these structures. This paper describes the experimental program, called VINIL, developed at the CEA at Cadarache. After a brief description of the experimental facility and of the experimental results, this paper proposes an evaluation of the risk of progressive deformation on an elastic basis: various simplified methods of analysis were used and are compared with experimental results

  13. Registered plant list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...the Plant DB link list in simple search page) Genome analysis methods Presence or... absence of Genome analysis methods information in this DB (link to the Genome analysis methods information ...base Site Policy | Contact Us Registered plant list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  14. Research Directions for Cyber Experimentation: Workshop Discussion Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    DeWaard, Elizabeth [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Deccio, Casey [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fritz, David Jakob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tarman, Thomas D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories hosted a workshop on August 11, 2017 entitled "Research Directions for Cyber Experimentation," which focused on identifying and addressing research gaps within the field of cyber experimentation , particularly emulation testbeds . This report mainly documents the discussion toward the end of the workshop, which included research gaps such as developing a sustainable research infrastructure, exp anding cyber experimentation, and making the field more accessible to subject matter experts who may not have a background in computer science . Other gaps include methodologies for rigorous experimentation, validation, and uncertainty quantification, which , if addressed, also have the potential to bridge the gap between cyber experimentation and cyber engineering. Workshop attendees presented various ways to overcome these research gaps, however the main conclusion for overcoming these gaps is better commun ication through increased workshops, conferences, email lists, and slack chann els, among other opportunities.

  15. Natural vibration experimental analysis of Novovoronezhskaya NPP main building

    International Nuclear Information System (INIS)

    Zoubkov, D.; Isaikin, A.; Shablinsky, G.; Lopanchuk, A.; Nefedov, S.

    2005-01-01

    1. Natural vibration frequencies are main characteristics of buildings and structures which allow to give integral estimation of their in-service state. Even relatively small changes of these frequencies as compared to the initially registered values point to serious defects of building structures. In this paper we analyzed natural vibration frequencies and natural modes of the main building (MB) of Novovoronezhskaya NPP operating nuclear unit with WWER-440 type reactor. The MB consists of a reactor compartment (RC), a machine room (MR) and an electric device (ED) unit positioned in between. 2. Natural vibration frequencies and natural modes of the MB were determined experimentally by analyzing its microvibrations caused by operation of basic equipment (turbines, pumps, etc.). Microvibrations of the main building were measured at 12 points. At each point measurements were carried out along two or three mutually perpendicular vibration directions. Spectral analysis of vibration records has been conducted. Identification of natural vibration frequencies was carried out on the basis of the spectral peaks and plotted vibration modes (taking into account operating frequencies of the basic equipment of the power generating unit). On the basis of the measurement results three transverse modes and corresponding natural vibration frequencies of the MB, one longitudinal mode and corresponding natural vibration frequency of the MB and two natural frequencies of vertical vibrations of RC and MR floor trusses (1st and 2nd symmetric forms) were determined. Dynamic characteristics of the main building of NV NPP resulting from full scale researches are supposed to be used as one of building structure stability criteria. (authors)

  16. Linking process and structure in the friction stir scribe joining of dissimilar materials: A computational approach with experimental support

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Varun; Upadhyay, Piyush; Fifield, Leonard S.; Roosendaal, Timothy; Sun, Xin; Nelaturu, Phalgun; Carlson, Blair

    2018-04-01

    The friction stir welding (FSW) is a popular technique to join dissimilar materials in numerous applications. The solid state nature of the process enables joining materials with strikingly different physical properties. For the welds in lap configuration, an enhancement to this technology is made by introducing a short hard insert, referred to as cutting-scribe, at the bottom of the tool pin. The cutting-scribe induces deformation in the bottom plate which leads to the formation of mechanical interlocks or hook like structures at the interface of two materials. A thermo-mechanically coupled computational model employing coupled Eulerian-Lagrangian approach is developed to quantitatively capture the morphology of these interlocks during the FSW process. The simulations using developed model are validated by the experimental observations.The identified interface morphology coupled with the predicted temperature field from this process-structure model can then be used to estimate the post-weld microstructure and joint strength.

  17. Performance Analysis of Free-Space Optical Links Over Malaga (M) Turbulence Channels with Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique; Yilmaz, Ferkan; Alouini, Mohamed-Slim

    2015-01-01

    In this work, we present a unified performance analysis of a free-space optical (FSO) link that accounts for pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection (IM/DD) as well as heterodyne detection). More specifically, we present unified exact closedform expressions for the cumulative distribution function, the probability density function, the moment generating function, and the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system, all in terms of the Meijer’s G function except for the moments that is in terms of simple elementary functions. We then capitalize on these unified results to offer unified exact closed-form expressions for various performance metrics of FSO link transmission systems, such as, the outage probability, the scintillation index (SI), the average error rate for binary and M-ary modulation schemes, and the ergodic capacity (except for IM/DD technique, where we present closed-form lower bound results), all in terms of Meijer’s G functions except for the SI that is in terms of simple elementary functions. Additionally, we derive the asymptotic results for all the expressions derived earlier in terms of Meijer’s G function in the high SNR regime in terms of simple elementary functions via an asymptotic expansion of the Meijer’s G function. We also derive new asymptotic expressions for the ergodic capacity in the low as well as high SNR regimes in terms of simple elementary functions via utilizing moments. All the presented results are verified via computer-based Monte-Carlo simulations.

  18. Performance Analysis of Free-Space Optical Links Over Malaga (M) Turbulence Channels with Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique

    2015-08-12

    In this work, we present a unified performance analysis of a free-space optical (FSO) link that accounts for pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection (IM/DD) as well as heterodyne detection). More specifically, we present unified exact closedform expressions for the cumulative distribution function, the probability density function, the moment generating function, and the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system, all in terms of the Meijer’s G function except for the moments that is in terms of simple elementary functions. We then capitalize on these unified results to offer unified exact closed-form expressions for various performance metrics of FSO link transmission systems, such as, the outage probability, the scintillation index (SI), the average error rate for binary and M-ary modulation schemes, and the ergodic capacity (except for IM/DD technique, where we present closed-form lower bound results), all in terms of Meijer’s G functions except for the SI that is in terms of simple elementary functions. Additionally, we derive the asymptotic results for all the expressions derived earlier in terms of Meijer’s G function in the high SNR regime in terms of simple elementary functions via an asymptotic expansion of the Meijer’s G function. We also derive new asymptotic expressions for the ergodic capacity in the low as well as high SNR regimes in terms of simple elementary functions via utilizing moments. All the presented results are verified via computer-based Monte-Carlo simulations.

  19. Analysis of growth hormone and lactogenic binding sites cross-linked to iodinated human growth hormone

    International Nuclear Information System (INIS)

    Hughes, J.P.; Simpson, J.S.; Friesen, H.G.

    1983-01-01

    GH (GHR) and lactogenic receptors were analyzed after use of the cross-linking reagent ethylene glycol bis-(succinimidyl succinate) to attach covalently iodinated human GH (hGH) to binding proteins 1) on intact IM-9 lymphocytes, 2) in a partially purified GHR preparation from rabbit liver, and 3) in crude microsomal fractions from rabbit liver, rabbit mammary gland, and rat liver. The latter two microsomal preparations contain primarily lactogenic receptors, whereas in IM-9 lymphocytes and the rabbit liver preparations, GHR predominate. Cross-linked [125I]hGH-receptor complexes were solubilized, reduced, and separated on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Analysis of proteins cross-linked to [125I]hGH in the microsomal fraction from rabbit liver showed a specifically labeled complex with an estimated molecular weight (mol wt) of 75K. A slightly lower mol wt (71K) was determined for the complex labeled in the purified GHR preparation. In contrast to the relatively low mol wt complexes in rabbit liver, a complex that migrated with an apparent mol wt of 130K was identified in IM-9 lymphocytes. Labeled complexes were identified at 66K from rat liver and 61K from rabbit mammary gland. If it is assumed that hGH contributes 21K to the mol wt of the radiolabeled complexes, then the approximate mol wts of hGH-binding sites are 50-54K from rabbit liver, 109K from IM-9 lymphocytes, 45K from rat liver, and 40K from rabbit mammary gland

  20. Development of an experimental apparatus for boiling analysis

    International Nuclear Information System (INIS)

    Castro, A.J.A. de.

    1984-04-01

    The nucleate boiling is the most interesting boiling regime for practical appliccations, including nuclear reactor engineering. such regime is characterized by very high heat transfer rates with only small surface superheating. An experimental apparatus is developed for studying parameters which affect nucleate boiling. The following parameters are analysed: pressure, fluid velocity and the fluid temperature at the test section entrance. The performance of experimental apparatus is analysed by results and by problems raised by the oeration of setup. (Author) [pt

  1. Update History of This Database - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...B link & Genome analysis methods English archive site is opened. 2012/08/08 PGDBj... Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods is opened. About This...ate History of This Database - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  2. An Experimental Test of a Causal Link between Problem-Solving Performance and Reproductive Success in Wild Great Tits

    Directory of Open Access Journals (Sweden)

    Laure Cauchard

    2017-09-01

    Full Text Available Recent studies have uncovered relationships between measures of various cognitive performances and proxies of fitness such as reproductive success in non-human animals. However, to better understand the evolution of cognition in the wild, we still have to determine the causality of these relationships and the underlying mechanisms. The cognitive ability of an individual may directly influence its ability to raise many and/or high quality young through for example its provisioning ability. Conversely, large and/or high quality broods may lead to high parental motivation to solve problems related to their care. To answer this question, we manipulated reproductive success through brood size and measured subsequent problem-solving performance in wild great tit parents. Our results show that brood size manipulation did not affect the probability to solve the task. Moreover, solver pairs fledged more young than non-solver pairs independently of brood size treatment in one of the two experimental years and they showed higher nestling provisioning rate in both years. Overall, it shows that problem-solving performance was not driven by motivation and suggest that problem-solvers may achieve higher fledging success through higher provisioning rates. Our study constitutes a first key step toward a mechanistic understanding of the consequences of innovation ability for individual fitness in the wild.

  3. PVA-PEG physically cross-linked hydrogel film as a wound dressing: experimental design and optimization.

    Science.gov (United States)

    Ahmed, Afnan Sh; Mandal, Uttam Kumar; Taher, Muhammad; Susanti, Deny; Jaffri, Juliana Md

    2017-04-05

    The development of hydrogel films as wound healing dressings is of a great interest owing to their biological tissue-like nature. Polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogels loaded with asiaticoside, a standardized rich fraction of Centella asiatica, were successfully developed using the freeze-thaw method. Response surface methodology with Box-Behnken experimental design was employed to optimize the hydrogels. The hydrogels were characterized and optimized by gel fraction, swelling behavior, water vapor transmission rate and mechanical strength. The formulation with 8% PVA, 5% PEG 400 and five consecutive freeze-thaw cycles was selected as the optimized formulation and was further characterized by its drug release, rheological study, morphology, cytotoxicity and microbial studies. The optimized formulation showed more than 90% drug release at 12 hours. The rheological properties exhibited that the formulation has viscoelastic behavior and remains stable upon storage. Cell culture studies confirmed the biocompatible nature of the optimized hydrogel formulation. In the microbial limit tests, the optimized hydrogel showed no microbial growth. The developed optimized PVA/PEG hydrogel using freeze-thaw method was swellable, elastic, safe, and it can be considered as a promising new wound dressing formulation.

  4. Population distribution of flexible molecules from maximum entropy analysis using different priors as background information: application to the Φ, Ψ-conformational space of the α-(1-->2)-linked mannose disaccharide present in N- and O-linked glycoproteins.

    Science.gov (United States)

    Säwén, Elin; Massad, Tariq; Landersjö, Clas; Damberg, Peter; Widmalm, Göran

    2010-08-21

    The conformational space available to the flexible molecule α-D-Manp-(1-->2)-α-D-Manp-OMe, a model for the α-(1-->2)-linked mannose disaccharide in N- or O-linked glycoproteins, is determined using experimental data and molecular simulation combined with a maximum entropy approach that leads to a converged population distribution utilizing different input information. A database survey of the Protein Data Bank where structures having the constituent disaccharide were retrieved resulted in an ensemble with >200 structures. Subsequent filtering removed erroneous structures and gave the database (DB) ensemble having three classes of mannose-containing compounds, viz., N- and O-linked structures, and ligands to proteins. A molecular dynamics (MD) simulation of the disaccharide revealed a two-state equilibrium with a major and a minor conformational state, i.e., the MD ensemble. These two different conformation ensembles of the disaccharide were compared to measured experimental spectroscopic data for the molecule in water solution. However, neither of the two populations were compatible with experimental data from optical rotation, NMR (1)H,(1)H cross-relaxation rates as well as homo- and heteronuclear (3)J couplings. The conformational distributions were subsequently used as background information to generate priors that were used in a maximum entropy analysis. The resulting posteriors, i.e., the population distributions after the application of the maximum entropy analysis, still showed notable deviations that were not anticipated based on the prior information. Therefore, reparameterization of homo- and heteronuclear Karplus relationships for the glycosidic torsion angles Φ and Ψ were carried out in which the importance of electronegative substituents on the coupling pathway was deemed essential resulting in four derived equations, two (3)J(COCC) and two (3)J(COCH) being different for the Φ and Ψ torsions, respectively. These Karplus relationships are denoted

  5. Respiromics – An integrative analysis linking mitochondrial bioenergetics to molecular signatures

    Directory of Open Access Journals (Sweden)

    Ellen Walheim

    2018-03-01

    Full Text Available Objective: Energy metabolism is challenged upon nutrient stress, eventually leading to a variety of metabolic diseases that represent a major global health burden. Methods: Here, we combine quantitative mitochondrial respirometry (Seahorse technology and proteomics (LC-MS/MS-based total protein approach to understand how molecular changes translate to changes in mitochondrial energy transduction during diet-induced obesity (DIO in the liver. Results: The integrative analysis reveals that significantly increased palmitoyl-carnitine respiration is supported by an array of proteins enriching lipid metabolism pathways. Upstream of the respiratory chain, the increased capacity for ATP synthesis during DIO associates strongest to mitochondrial uptake of pyruvate, which is routed towards carboxylation. At the respiratory chain, robust increases of complex I are uncovered by cumulative analysis of single subunit concentrations. Specifically, nuclear-encoded accessory subunits, but not mitochondrial-encoded or core units, appear to be permissive for enhanced lipid oxidation. Conclusion: Our integrative analysis, that we dubbed “respiromics”, represents an effective tool to link molecular changes to functional mechanisms in liver energy metabolism, and, more generally, can be applied for mitochondrial analysis in a variety of metabolic and mitochondrial disease models. Keywords: Mitochondria, Respirometry, Proteomics, Mitochondrial pyruvate carrier, Liver disease, Bioenergetics, Obesity, Diabetes

  6. Theoretical and experimental analysis of the induction generators; Analise teorica e experimental do gerador de inducao

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Marcel; Martins Neto, Luciano; Calixto, Wesley Pacheco; Gontijo, Andre Luiz; Alves, Aylton Jose [Universidade Federal de Uberlandia (LMEE/FEELT/UFU), MG (Brazil). Fac. de Engenharia Eletrica. Lab. de Maquinas Eletricas Especiais], E-mails: marcel@mestrado.ufu.br, lmn@ufu.br, wpcalixto@ieee.org, aja@cefetgo.br

    2009-10-15

    Due to its lower costs, robustness, reduced maintenance and easy operation, the induction generator shows to be an economic alternative in small power generator systems. This work presents the initial phase of pertinent studies about the employment of the induction generator directly connected to the electrical power grid in a pilot project to be implemented at the Santa Luzia SHP. A project that aims to raise relevant operational aspects and to evidence some advantages about the employment of the induction generator in small power generator systems. This phase comprises the experimentation of an induction generator directly connected to the power grid in a laboratorial scale, plus a computational modeling which represents the same. This computational modeling takes into account loads variations which are being supplied by the generator, unbalance between phases and magnetic saturation effects, such as harmonic distortions in the generated currents. From the experimental model collected data, a theoretical-experimental confrontation of the computational modeling is made, where quantitative and qualitative analyses about the operational characteristics of the machine are made. The results of this work will head the operation and supervision of the SHP induction machine. (author)

  7. Power-Aware Routing and Network Design with Bundled Links: Solutions and Analysis

    Directory of Open Access Journals (Sweden)

    Rosario G. Garroppo

    2013-01-01

    Full Text Available The paper deeply analyzes a novel network-wide power management problem, called Power-Aware Routing and Network Design with Bundled Links (PARND-BL, which is able to take into account both the relationship between the power consumption and the traffic throughput of the nodes and to power off both the chassis and even the single Physical Interface Card (PIC composing each link. The solutions of the PARND-BL model have been analyzed by taking into account different aspects associated with the actual applicability in real network scenarios: (i the time for obtaining the solution, (ii the deployed network topology and the resulting topology provided by the solution, (iii the power behavior of the network elements, (iv the traffic load, (v the QoS requirement, and (vi the number of paths to route each traffic demand. Among the most interesting and novel results, our analysis shows that the strategy of minimizing the number of powered-on network elements through the traffic consolidation does not always produce power savings, and the solution of this kind of problems, in some cases, can lead to spliting a single traffic demand into a high number of paths.

  8. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia.

    Science.gov (United States)

    Goodwin, Alice F; Larson, Jacinda R; Jones, Kyle B; Liberton, Denise K; Landan, Maya; Wang, Zhifeng; Boekelheide, Anne; Langham, Margaret; Mushegyan, Vagan; Oberoi, Snehlata; Brao, Rosalie; Wen, Timothy; Johnson, Ramsey; Huttner, Kenneth; Grange, Dorothy K; Spritz, Richard A; Hallgrímsson, Benedikt; Jheon, Andrew H; Klein, Ophir D

    2014-09-01

    Hypohidrotic ectodermal dysplasia (HED) is the most prevalent type of ectodermal dysplasia (ED). ED is an umbrella term for a group of syndromes characterized by missing or malformed ectodermal structures, including skin, hair, sweat glands, and teeth. The X-linked recessive (XL), autosomal recessive (AR), and autosomal dominant (AD) types of HED are caused by mutations in the genes encoding ectodysplasin (EDA1), EDA receptor (EDAR), or EDAR-associated death domain (EDARADD). Patients with HED have a distinctive facial appearance, yet a quantitative analysis of the HED craniofacial phenotype using advanced three-dimensional (3D) technologies has not been reported. In this study, we characterized craniofacial morphology in subjects with X-linked hypohidrotic ectodermal dysplasia (XLHED) by use of 3D imaging and geometric morphometrics (GM), a technique that uses defined landmarks to quantify size and shape in complex craniofacial morphologies. We found that the XLHED craniofacial phenotype differed significantly from controls. Patients had a smaller and shorter face with a proportionally longer chin and midface, prominent midfacial hypoplasia, a more protrusive chin and mandible, a narrower and more pointed nose, shorter philtrum, a narrower mouth, and a fuller and more rounded lower lip. Our findings refine the phenotype of XLHED and may be useful both for clinical diagnosis of XLHED and to extend understanding of the role of EDA in craniofacial development.

  9. License - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...t list, Marker list, QTL list, Plant DB link & Genome analysis methods © Satoshi ... Policy | Contact Us License - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  10. ArrayExpress update--trends in database growth and links to data analysis tools.

    Science.gov (United States)

    Rustici, Gabriella; Kolesnikov, Nikolay; Brandizi, Marco; Burdett, Tony; Dylag, Miroslaw; Emam, Ibrahim; Farne, Anna; Hastings, Emma; Ison, Jon; Keays, Maria; Kurbatova, Natalja; Malone, James; Mani, Roby; Mupo, Annalisa; Pedro Pereira, Rui; Pilicheva, Ekaterina; Rung, Johan; Sharma, Anjan; Tang, Y Amy; Ternent, Tobias; Tikhonov, Andrew; Welter, Danielle; Williams, Eleanor; Brazma, Alvis; Parkinson, Helen; Sarkans, Ugis

    2013-01-01

    The ArrayExpress Archive of Functional Genomics Data (http://www.ebi.ac.uk/arrayexpress) is one of three international functional genomics public data repositories, alongside the Gene Expression Omnibus at NCBI and the DDBJ Omics Archive, supporting peer-reviewed publications. It accepts data generated by sequencing or array-based technologies and currently contains data from almost a million assays, from over 30 000 experiments. The proportion of sequencing-based submissions has grown significantly over the last 2 years and has reached, in 2012, 15% of all new data. All data are available from ArrayExpress in MAGE-TAB format, which allows robust linking to data analysis and visualization tools, including Bioconductor and GenomeSpace. Additionally, R objects, for microarray data, and binary alignment format files, for sequencing data, have been generated for a significant proportion of ArrayExpress data.

  11. Corporate social responsibility practice of Malaysian public listed government-linked companies: A dimensional analysis

    Directory of Open Access Journals (Sweden)

    Lim Boon Keong

    2018-06-01

    Full Text Available This paper examines the corporate social responsibility (CSR practices of the Malaysian public-listed government-linked companies (GLCs using a dimensional analysis. Four dimensions of CSR activities, namely community, employees, environment and governance, are investigated to study the latest CSR practice of GLCs in year 2016. Each dimension is divided into three subcategories to further examine the performance of GLCs on a particular CSR area. This is the first paper in Malaysia which uses CSR ratings (obtained from CSRHub database to proxy for CSR practice. None of the past literature has been found to adopt this approach. The findings show that Malay-sian public-listed GLCs performed better in community, employees and environment dimensions, whilst tend to underperform in governance dimension.

  12. Human factors assessment in PRA using Task Analysis Linked Evaluation Technique (TALENT)

    International Nuclear Information System (INIS)

    Wells, J.E.; Banks, W.W.

    1991-01-01

    Thirty years ago the US military and US aviation industry, and more recently, in response to the US Three Mile Island and USSR Chernobyl accidents, the US commercial nuclear power industry, acknowledged that human error, as an immediate precursor, and as a latent or indirect influence in the form of training, maintainability, inservice test, and surveillance programs, is a primary contributor to unreality and risk in complex high-reliability systems. A 1985 Nuclear Regulatory Commission (NRC) study of Licensee Event Reports (LERs) suggests that upwards of 65% of commercial nuclear system failures involve human error. Despite the magnitude and nature of human error cited in that study, there has been limited attention to personnel-centered issues, especially person-to-person issues involving group processes, management and organizational environment. The paper discusses NRC integration and applications research with respect to the Task Analysis Linked Evaluation Technique (TALENT) in risk assessment applications

  13. Mass spectrometric analysis of a UV-cross-linked protein-DNA complex: tryptophans 54 and 88 of E. coli SSB cross-link to DNA

    DEFF Research Database (Denmark)

    Steen, Hanno; Petersen, Jørgen; Mann, Matthias

    2001-01-01

    acid and peptide entities present in such heteroconjugates. Sample preparation of the peptide-nucleic acid heteroconjugates is, therefore, a crucial step in any mass spectrometry-based analytical procedure. This study demonstrates the performance of four different MS-based strategies to characterize E....... coli single-stranded DNA binding protein (SSB) that was UV-cross-linked to a 5-iodouracil containing DNA oligomer. Two methods were optimized to circumvent the need for standard liquid chromatography and gel electrophoresis, thereby dramatically increasing the overall sensitivity of the analysis...

  14. Molecular Infectious Disease Epidemiology: Survival Analysis and Algorithms Linking Phylogenies to Transmission Trees

    Science.gov (United States)

    Kenah, Eben; Britton, Tom; Halloran, M. Elizabeth; Longini, Ira M.

    2016-01-01

    Recent work has attempted to use whole-genome sequence data from pathogens to reconstruct the transmission trees linking infectors and infectees in outbreaks. However, transmission trees from one outbreak do not generalize to future outbreaks. Reconstruction of transmission trees is most useful to public health if it leads to generalizable scientific insights about disease transmission. In a survival analysis framework, estimation of transmission parameters is based on sums or averages over the possible transmission trees. A phylogeny can increase the precision of these estimates by providing partial information about who infected whom. The leaves of the phylogeny represent sampled pathogens, which have known hosts. The interior nodes represent common ancestors of sampled pathogens, which have unknown hosts. Starting from assumptions about disease biology and epidemiologic study design, we prove that there is a one-to-one correspondence between the possible assignments of interior node hosts and the transmission trees simultaneously consistent with the phylogeny and the epidemiologic data on person, place, and time. We develop algorithms to enumerate these transmission trees and show these can be used to calculate likelihoods that incorporate both epidemiologic data and a phylogeny. A simulation study confirms that this leads to more efficient estimates of hazard ratios for infectiousness and baseline hazards of infectious contact, and we use these methods to analyze data from a foot-and-mouth disease virus outbreak in the United Kingdom in 2001. These results demonstrate the importance of data on individuals who escape infection, which is often overlooked. The combination of survival analysis and algorithms linking phylogenies to transmission trees is a rigorous but flexible statistical foundation for molecular infectious disease epidemiology. PMID:27070316

  15. Performance analysis of stationary Hadamard matrix diffusers in free-space optical communication links

    Science.gov (United States)

    Burrell, Derek J.; Middlebrook, Christopher T.

    2017-08-01

    Wireless communication systems that employ free-space optical links in place of radio/microwave technologies carry substantial benefits in terms of data throughput, network security and design efficiency. Along with these advantages comes the challenge of counteracting signal degradation caused by atmospheric turbulence in free-space environments. A fully coherent laser source experiences random phase delays along its traversing path in turbulent conditions forming a speckle pattern and lowering the received signal-to-noise ratio upon detection. Preliminary research has shown that receiver-side speckle contrast may be significantly reduced and signal-to-noise ratio increased accordingly through the use of a partially coherent light source. While dynamic diffusers and adaptive optics solutions have been proven effective, they also add expense and complexity to a system that relies on accessibility and robustness for successful implementation. A custom Hadamard diffractive matrix design is used to statically induce partial coherence in a transmitted beam to increase signal-to-noise ratio for experimental turbulence scenarios. Atmospheric phase screens are generated using an open-source software package and subsequently loaded into a spatial light modulator using nematic liquid crystals to modulate the phase.

  16. Experimental Methods for the Analysis of Optimization Algorithms

    DEFF Research Database (Denmark)

    of solution quality, runtime and other measures; and the third part collects advanced methods from experimental design for configuring and tuning algorithms on a specific class of instances with the goal of using the least amount of experimentation. The contributor list includes leading scientists......, computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on different...

  17. Using Aoristic Analysis to Link Remote and Ground-Level Phenological Observations

    Science.gov (United States)

    Henebry, G. M.

    2013-12-01

    Phenology is about observing events in time and space. With the advent of publically accessible geospatial datastreams and easy to use mapping software, specifying where an event occurs is much less of a challenge than it was just two decades ago. In contrast, specifying when an event occurs remains a nontrivial function of a population of organismal responses, sampling interval, compositing period, and reporting precision. I explore how aoristic analysis can be used to analyzing spatiotemporal events for which the location is known to acceptable levels of precision but for which temporal coordinates are poorly specified or only partially bounded. Aoristic analysis was developed in the late 1990s in the field of quantitative criminology to leverage temporally imprecise geospatial data of crime reports. Here I demonstrate how aoristic analysis can be used to link remotely sensed observations of land surface phenology to ground-level observations of organismal phenophase transitions. Explicit representation of the windows of temporal uncertainty with aoristic weights enables cross-validation exercises and forecasting efforts to avoid false precision.

  18. Marketing Strategy Analysis Based On SWOT At PT. Muba Link Business Unit Of Wisma Ranggonang

    Directory of Open Access Journals (Sweden)

    Desi Ulpa Anggraini

    2017-09-01

    Full Text Available The purpose of this research was to know and analyze the marketing strategy based on SWOT analysis at PT. Muba Link Business unit Wisma Ranggonang Sekayu district Musi Banyuasin. The population of this research were the leadership and the employees of Wisma Ranggonang. This research was conducted by using descriptive research method with a quantitive approach in the form of quadrant position analysis by using SWOT Matrix analysis and after that it was proceed with the decision of making phase in the form of marketing strategy. The result showed that based on the external/internal Matrix get value of each strength factor for about 1, weakness is 1.25 opportunity worth 1,285 and threat is 1,217. Meanwhile, based on cartesius diagram, the quadrant position of Wisma Ranggonang Sekayu was in the third quadrant supporting the turnaraound strategy, i.e. the company faces a huge market opportunity, but on the other hand it faces some internal conctraints/weakness. The focus of this company’s strategy was to minimize the internal company problems, so as to seize the more market opportunities. So, the initial hypothesis that Wisma Ranggonang Sekayu supports the growth/aggressive strategy was not fulfilled.

  19. Experimental analysis of pressurised humidification tower for humid air gas turbine cycles. Part A: Experimental campaign

    International Nuclear Information System (INIS)

    Pedemonte, A.A.; Traverso, A.; Massardo, A.F.

    2008-01-01

    One of the most interesting methods of water introduction in a gas turbine circuit is represented by the humid air turbine cycle (HAT). In the HAT cycle, the humidification can be provided by a pressurised saturator (i.e. humidification tower or saturation tower), this solution being known to offer several attractive features. This part A is focused on an experimental study of a pressurised humidification tower, with structured packing inside. After a description of the test rig employed to carry out the measuring campaign, the results relating to the thermodynamic process are presented and discussed. The experimental campaign was carried out over 162 working points, covering a relatively wide range of possible operating conditions. Details about measured data are provided in the appendix. It is shown that the saturator's behaviour, in terms of air outlet humidity and temperature, is primarily driven by, in decreasing order of relevance, the inlet water temperature, the inlet water over inlet dry air mass flow ratio and the inlet air temperature. Finally, the exit relative humidity is shown to be consistently over 100%, which may be explained partially by measurement accuracy and droplet entrainment, and partially by the non-ideal behaviour of air-steam mixtures close to saturation

  20. Finite Element Analysis for Active-force Control on Vibration of a Flexible Single-link Manipulator

    Directory of Open Access Journals (Sweden)

    Abdul Kadir Muhammad

    2015-10-01

    Full Text Available The purposes of this research are to formulate the equations of motion of the system, to develop computational codes by a finite element analysis in order to perform dynamics simulation with vibration control, to propose an effective control scheme using active-force (AF control a flexible single-link manipulator. The system used in this paper consists of an aluminum beam as a flexible link, a clamp-part, a servo motor to rotate the link and a piezoelectric actuator to control vibration. Computational codes on time history responses, FFT (Fast Fourier Transform processing and eigenvalues-eigenvectors analysis were developed to calculate dynamic behavior of the link. Furthermore, the AF control was designed to drive the piezoelectric actuator. Calculated results have revealed that the vibration of the system can be suppressed effectively.

  1. Strategic loan defaults and coordination : An experimental analysis

    NARCIS (Netherlands)

    Trautmann, S.T.; Vlahu, R.

    2013-01-01

    This paper experimentally studies the impact of bank and borrower fundamentals on loan repayment. We find that solvent borrowers are more likely to default strategically when the bank’s expected strength is low, although loan repayment is a Pareto dominant Nash equilibrium. Borrowers are also less

  2. Experimental Analysis and Model Validation of an Opaque Ventilated Facade

    DEFF Research Database (Denmark)

    López, F. Peci; Jensen, Rasmus Lund; Heiselberg, Per

    2012-01-01

    Natural ventilation is a convenient way of reducing energy consumption in buildings. In this study an experimental module of an opaque ventilated façade (OVF) was built and tested for assessing its potential of supplying free ventilation and air preheating for the building. A numerical model was ...

  3. RABR Analysis - Rating Degrees of Openness in Experimental Repertory

    DEFF Research Database (Denmark)

    Bergstrøm-Nielsen, Carl

    2017-01-01

    "Openness" in experimental music is an imprecise notion. Works may be characterised according to Random Access and Broadness. The first describes whether, and how much, elements may be played independently of a fixed sequence. The second, how much latitude can exist in the interpretation...

  4. Analysis of experimental data sets for local scour depth around ...

    African Journals Online (AJOL)

    The performance of soft computing techniques to analyse and interpret the experimental data of local scour depth around bridge abutment, measured at different laboratory conditions and environment, is presented. The scour around bridge piers and abutments is, in the majority of cases, the main reason for bridge failures.

  5. Mental representation and mental practice: experimental investigation on the functional links between motor memory and motor imagery.

    Directory of Open Access Journals (Sweden)

    Cornelia Frank

    Full Text Available Recent research on mental representation of complex action has revealed distinct differences in the structure of representational frameworks between experts and novices. More recently, research on the development of mental representation structure has elicited functional changes in novices' representations as a result of practice. However, research investigating if and how mental practice adds to this adaptation process is lacking. In the present study, we examined the influence of mental practice (i.e., motor imagery rehearsal on both putting performance and the development of one's representation of the golf putt during early skill acquisition. Novice golfers (N = 52 practiced the task of golf putting under one of four different practice conditions: mental, physical, mental-physical combined, and no practice. Participants were tested prior to and after a practice phase, as well as after a three day retention interval. Mental representation structures of the putt were measured, using the structural dimensional analysis of mental representation. This method provides psychometric data on the distances and groupings of basic action concepts in long-term memory. Additionally, putting accuracy and putting consistency were measured using two-dimensional error scores of each putt. Findings revealed significant performance improvements over the course of practice together with functional adaptations in mental representation structure. Interestingly, after three days of practice, the mental representations of participants who incorporated mental practice into their practice regime displayed representation structures that were more similar to a functional structure than did participants who did not incorporate mental practice. The findings of the present study suggest that mental practice promotes the cognitive adaptation process during motor learning, leading to more elaborate representations than physical practice only.

  6. Experimental Design for Sensitivity Analysis of Simulation Models

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2001-01-01

    This introductory tutorial gives a survey on the use of statistical designs for what if-or sensitivity analysis in simulation.This analysis uses regression analysis to approximate the input/output transformation that is implied by the simulation model; the resulting regression model is also known as

  7. Experimental demonstration of bidirectional up to 40 Gbit/s QPSK coherent free-space optical communication link over ∼1 km

    Science.gov (United States)

    Feng, Xianglian; Wu, Zhihang; Wang, Tianshu; Zhang, Peng; Li, Xiaoyan; Jiang, Huilin; Su, Yuwei; He, Hongwei; Wang, Xiaoyan; Gao, Shiming

    2018-03-01

    Advanced multi-level modulation formats have shown their great potential in high-speed and high-spectral-efficiency optical communications. Using quadrature phase-shift keying (QPSK) modulation format for free-space optical (FSO) communication, a bidirectional high-speed FSO transmission link with the bit rates of up to 40 Gbit/s over ∼1 km, between two buildings in the campus of Changchun University of Science and Technology, Changchun, China, is experimentally demonstrated cooperating by capture and tracking systems. The eye-diagrams and constellation diagrams of the transmitted QPSK signals are clearly observed. By comparing the bit error rate (BER) curves before and after transmission, one can find that the receiving powers are both less than -16.5 dBm for the forward and backward transmissions of the bidirectional 20, 30, and 40 Gbit/s FSO links, and their power penalties due to the phase fluctuation of the atmospheric channel are both less than 2.6 dB, at the BER of 3.8 ×10-3.

  8. Experimental analysis of chaos in under actuated electromechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Hernandez, H. G. [Universidad la Salle, Mexico, D.F. (Mexico); Alvarez Gallegos, Jaime [Instituto Politecnico Nacional (Mexico); Alvarez Gallegos Joaquin [Centro de Investigacion Cientifica y de Educacion Superior de Ensenada, Ensenada, Baja California (Mexico)

    2001-10-01

    An under actuated system is a kind of non-autonomous robotic system in which there are more links than actuators. The complexity of the dynamical behavior of these systems allows a wide variety of steady-state responses. The reconstruction of attractors based on time series obtained from measurements of one of the variables of a two-link, planar, under actuated robot called Pendubot, is developed. Time-delay coordinates, average mutual information, and percentage of false nearest neighbors' methods are used to reconstruct the invariant sets. It is shown that, under the action of a periodic torque, the Pendubot can display a variety of steady-state dynamics, including strange attractors. [Spanish] Un sistema electromecanico subactuado es un tipo de sistema robotico no autonomo que cuenta con mas eslabones que actuadores. La complejidad del comportamiento dinamico de estos sistemas permite una gran variedad de respuestas en estado estacionario. En este trabajo se desarrolla la reconstruccion de atractores basada en series de tiempo obtenidas a partir de mediciones de una de las variables de un robot planar de dos grados de libertad subactuado llamado Pendubot. A fin de reconstruir los conjuntos invariantes, se utilizan tecnica como retraso de coordenadas, promedio de informacion mutua y porcentaje de falsos vecinos cercanos. Se muestra que bajo la accion de un torque periodico, el Pendubot puede desplegar una variedad de comportamientos dinamicos en estado estacionario incluyendo atractores extranos.

  9. A Model for the Detailed Analysis of Radio Links Involving Tree Canopies

    Directory of Open Access Journals (Sweden)

    F. Perez-Fontan

    2016-12-01

    Full Text Available Detailed analysis of tree canopy interaction with incident radiowaves has mainly been limited to remote sensing for the purpose of forest classification among many other applications. This represents a monostatic configuration, unlike the case of communication links, which are bistatic. In general, link analyses have been limited to the application of simple, empirical formulas based on the use of specific attenuation values in dB/m and the traversed vegetated mass as, e.g., the model in Recommendation ITU-R P.833-8 [1]. In remote sensing, two main techniques are used: Multiple Scattering Theory (MST [2][5] and Radiative Transfer Theory (RT, [5] and [6]. We have paid attention in the past to MST [7][10]. It was shown that a full application of MST leads to very long computation times which are unacceptable in the case where we have to analyze a scenario with several trees. Extensive work using MST has been also presented by others in [11][16] showing the interest in this technique. We have proposed a simplified model for scattering from tree canopies based on a hybridization of MST and a modified physical optics (PO approach [16]. We assume that propagation through a canopy is accounted for by using the complex valued propagation constant obtained by MST. Unlike the case when the full MST is applied, the proposed approach offers significant benefits including a direct software implementation and acceptable computation times even for high frequencies and electrically large canopies. The proposed model thus replaces the coherent component in MST, significant in the forward direction, but keeps the incoherent or diffuse scattering component present in all directions. The incoherent component can be calculated within reasonable times. Here, we present tests of the proposed model against MST using an artificial single-tree scenario at 2 GHz and 10 GHz.

  10. Analysis of the factors linked to a diagnosis of attention deficit hyperactivity disorder in children.

    Science.gov (United States)

    Rivas-Juesas, C; de Dios, J G; Benac-Prefaci, M; Colomer-Revuelta, J

    2017-09-01

    Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder originating from multiple factors. The aim of this study is to determine the percentage of patients with ADHD out of all patients referred to our clinic for assessment, and to explore the epidemiological and clinical factors linked to this diagnosis. retrospective analytical study of a sample of patients under 15 years old sent to the paediatric neurology clinic for suspected ADHD. DSM-IV criteria were used for diagnosis. We completed a binary logistic regression analysis to determine which risk factors were associated with the diagnosis. Of the 280 selected patients, 224 were male (male/female ratio 4:1); mean age (SD) was 8.4 (3.08) years. Almost half (49%) of the patients were referred by their schools and 64.9% were born in the second half of the year, but this tendency was more marked in girls than in boys. Assessment according to DSM-IV criteria resulted in diagnosis of 139 subjects (49.7%). The risk factors linked to diagnosis were male sex, parents with ADHD, associated sleep disorders, tics, and absence of neurodevelopmental delay. Only half of the children referred for suspected ADHD were diagnosed with that condition, and most were among the youngest in their classes, which suggests that suspected ADHD is overestimated. An exhaustive clinical interview investigating the family's psychological disorders and the patient's sleep disorders and tics is needed to improve the diagnostic process. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Birefringence of cellotape: Jones representation and experimental analysis

    International Nuclear Information System (INIS)

    Belendez, Augusto; Frances, Jorge; Neipp, Cristian; Fernandez, Elena

    2010-01-01

    In this paper, we analyse a simple experiment to study the effects of polarized light. A simple optical system composed of a polarizer, a retarder (cellotape) and an analyser is used to study the effect on the polarization state of the light which impinges on the setup. The optical system is characterized by means of a Jones matrix, and a simple procedure based on Jones vectors is used to obtain an expression for the intensity after the light passes through the optical system. The light intensity is measured by a photodetector and the expression obtained theoretically is experimentally validated. By fitting the experimental intensity data, the value of the retardation introduced by the retarder can also be obtained.

  12. Experimental and Mathematical Analysis of Multilayer Insulation below 80 K

    CERN Document Server

    Chorowski, M; Parente, C; Riddone, G

    2000-01-01

    The Large Hadron Collider [1], presently under construction at CERN, will make an extensive use of multilayer insulation system (MLI). The total surface to be insulated will be of about 80000 m2. A mathematical model has been developed to describe the heat flux through MLI from 80 K to 4.2 K. The total heat flux between the layers is the result of three distinct heat transfer modes: radiation, residual gas conduction and solid conduction. The mathematical model enables prediction of MLI behavior with regard to different MLI parameters, such as gas insulation pressure, number of layers and boundary temperatures. The calculated values have been compared to the experimental measurements carried out at CERN. Theoretical and experimental results revealed to be in good agreement, especially for insulation vacuum between 10-5 Pa and 10-3 Pa.

  13. CFD analysis and experimental comparison of novel roof tile shapes

    Directory of Open Access Journals (Sweden)

    Michele Bottarelli

    2017-06-01

    Using an experimental rig, the air pressure difference and the volumetric flow rate between tiles have been measured for an existing Portoghese tile design over a range of pressures. Then, in order to understand the air flows under different conditions, a three-dimensional computational fluid dynamics (CFD model has been implemented to recreate the full geometry of the rig. The model was calibrated against the aforementioned experimental results, and run with boundary conditions simulating different wind directions. Even in the low velocities typical of average local wind patterns, the fluid dynamic problem remains complex because of the geometry of the gaps between the tiles. However, it has been possible to assess the coefficient of local head loss and then apply it in an analytical relationship between pressure drop and flow rate, taking into account the open area. The results have shown how the wind direction affects the air permeability and, therefore, important insights have been gathered for the design of novel tiles.

  14. Spectroscopic Analysis of Neurotransmitters: A Theoretical and Experimental Raman Study

    Science.gov (United States)

    Alonzo, Matthew

    Surface-enhanced Raman spectroscopy (SERS) was applied to investigate the feasibility in the detection and monitoring of the dopamine (DA) neurotransmitter adsorbed onto silver nanoparticles (Ag NPs) at 10-11 molar, a concentration far below physiological levels. In addition, density functional theory (DFT) calculations were obtained with the Gaussian-09 analytical suite software to generate the theoretical molecular configuration of DA in its neutral, cationic, anionic, and dopaminequinone states for the conversion of computer-simulated Raman spectra. Comparison of theoretical and experimental results show good agreement and imply the presence of dopamine in all of its molecular forms in the experimental setting. The dominant dopamine Raman bands at 750 cm-1 and 795 cm-1 suggest the adsorption of dopaminequinone onto the silver nanoparticle surface. The results of this experiment give good insight into the applicability of using Raman spectroscopy for the biodetection of neurotransmitters.

  15. Experimental Methods for the Analysis of Optimization Algorithms

    DEFF Research Database (Denmark)

    , computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on different...... in algorithm design, statistical design, optimization and heuristics, and most chapters provide theoretical background and are enriched with case studies. This book is written for researchers and practitioners in operations research and computer science who wish to improve the experimental assessment......In operations research and computer science it is common practice to evaluate the performance of optimization algorithms on the basis of computational results, and the experimental approach should follow accepted principles that guarantee the reliability and reproducibility of results. However...

  16. Experimental and theoretical analysis of shear wall failure

    International Nuclear Information System (INIS)

    Gantenbein, F.; Queval, J.C.; Dalbera, J.

    1993-01-01

    Thirteen walls with and without openings have been tested under seismic loading up to collapse and the test results have already been reported. A global model has been developed for the description of the hysteretic behaviour; it is based on the use of secant stiffness up to the steel yielding and on a slip model after yielding. Applications of this model to the walls with and without openings will be shown and the calculated top displacement will be compared with the measured one. The input load level leading to the failure is calculated with this non-linear model and the results are compared with the experimental values. The safety margin, which is defined as the ratio of the experimental load level leading to the failure to that obtained by linear calculation, will be given as a function of the mean excitation frequency

  17. Performance analysis of small-scale experimental facility of TWDEC

    International Nuclear Information System (INIS)

    Kawana, Ryoh; Ishikawa, Motoo; Takeno, Hiromasa; Yamamoto, Takayoshi; Yasaka, Yasuyoshi

    2008-01-01

    The objective of the present paper is to analyze small-scale experimental facilities of TWDEC (Travelling Wave type Direct Energy Converter) and to propose a modification in regard to a measuring device of the facilities by means of numerical simulation with the axisymmetrical two-dimensional approximation (a PIC method). The numerical simulation has given the following results: (1) tendency of the numerical results agree with the experimental results on the measured deceleration efficiency, (2) the deceleration efficiency measured in the experiment will increase if the radius of Faraday cup installed in the experiment increases and (3) the wave of condensation and rarefaction of measured electric charge density, which is averaged in the r-direction below the radius of Faraday cup, is not formed enough with a small radius of Faraday cup because of the r component of electric field which is induced by the electrode geometry

  18. Human factors assessment in PRA using task analysis linked evaluation technique (TALENT)

    International Nuclear Information System (INIS)

    Wells, J.E.; Banks, W.W.

    1990-01-01

    Human error is a primary contributor to risk in complex high-reliability systems. A 1985 U.S. Nuclear Regulatory Commission (USNRC) study of licensee event reports (LERs) suggests that upwards of 65% of commercial nuclear system failures involve human error. Since then, the USNRC has initiated research to fully and properly integrate human errors into the probabilistic risk assessment (PRA) process. The resulting implementation procedure is known as the Task Analysis Linked Evaluation Technique (TALENT). As indicated, TALENT is a broad-based method for integrating human factors expertise into the PRA process. This process achieves results which: (1) provide more realistic estimates of the impact of human performance on nuclear power safety, (2) can be fully audited, (3) provide a firm technical base for equipment-centered and personnel-centered retrofit/redesign of plants enabling them to meet internally and externally imposed safety standards, and (4) yield human and hardware data capable of supporting inquiries into human performance issues that transcend the individual plant. The TALENT procedure is being field-tested to verify its effectiveness and utility. The objectives of the field-test are to examine (1) the operability of the process, (2) its acceptability to the users, and (3) its usefulness for achieving measurable improvements in the credibility of the analysis. The field-test will provide the information needed to enhance the TALENT process

  19. MARKAL-MACRO: A linked model for energy-economy analysis

    International Nuclear Information System (INIS)

    Manne, A.S.; Wene, C.O.

    1992-02-01

    MARKAL-MACRO is an experiment in model linkage for energy and economy analysis. This new tool is intended as an improvement over existing methods for energy strategy assessment. It is designed specifically for estimating the costs and analyzing the technologies proposed for reducing environmental risks such as global climate change or regional air pollution. The greenhouse gas debate illustrates the usefulness of linked energy-economy models. A central issue is the coupling between economic growth, the level of energy demands, and the development of an energy system to supply these demands. The debate is often connected with alternative modeling approaches. The competing philosophies may be labeled ''top-down macroeconomic'' and ''bottom-up engineering'' perspectives. MARKAL is a systems engineering (physical process) analysis built on the concept of a Reference Energy System (RES). MARKAL is solved by means of dynamic linear programming. In most applications, the end use demands are fixed, and an economically efficient solution is obtained by minimizing the present value of energy system's costs throughout the planning horizon. MACRO is a macroeconomic model with an aggregated view of long-term economic growth. The basis input factors of production are capital, labor and individual forms of energy. MACRO is solved by nonlinear optimization

  20. Numerical and experimental analysis of vertical spray control patternators

    Directory of Open Access Journals (Sweden)

    F. Sarghini

    2013-09-01

    Full Text Available The experimental vertical spray control walls have the purpose of picking up the liquid delivered by trained sprayer for providing the liquid distribution profile in height. Theoretically this should correspond to the ideal profile, which consists in a uniform distribution on the vegetation. If the profile is different from the ideal, a parameter setup is required on the sprayer. Nonetheless, some problems are hidden in the aforementioned statements: i no wall measures exactly the distribution profile (i.e. the flow through the sections in the vertical plane, parallel to the direction of advancement of the sprayer. Compared to real profile, sensitive errors are introduced: the evaporation of the drops, the deviation of the air flows caused by the sensors panel themselves; by the possibility that the drops bounce on the wall panels, also due to the current of air that can push the liquid veil laterally or upwards, Moreover, everything varies depending on the geometry of the sensors, air velocity, air humidity; ii no one knows what exactly is the optimal distribution profile. It is often considered as optimal a profile that reflects the amount of leaf area subtended by each section absorber: however, it is evident that the path of the droplets changes according to the sprayer typology (eg. radial-flow or horizontal flows. In this work a combined numerical-experimental approach is adopted, in order to assess some of the aforementioned issues: numerical data obtained by using computational fluid dynamics models are compared and validated with experimental data, in order to assess the reliability of numerical simulations in configurations which are difficult to analyze using an experimental setup.

  1. [Experimental analysis of finishing lines in ceramometal restorations].

    Science.gov (United States)

    Gascón, F; Gil, J A; Fons, A; Badal, R

    1990-11-01

    The preparation is the first step of any tooth reconstruction. The biological integration of the protesis is depending on the marginal adaptation (finish line of the preparation), occlusal adaptation (occlusal reduction), longevity of the restoration (retention and luting) and esthetics. The effect the two finish line of the preparation is studied using experimental design. In porcelain-fused-to-metal the finish line of the preparation in chanfer is superior at the beveled shoulder, because proportioning better marginal adaptation.

  2. Experimental methods for the analysis of optimization algorithms

    CERN Document Server

    Bartz-Beielstein, Thomas; Paquete, Luis; Preuss, Mike

    2010-01-01

    In operations research and computer science it is common practice to evaluate the performance of optimization algorithms on the basis of computational results, and the experimental approach should follow accepted principles that guarantee the reliability and reproducibility of results. However, computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on diffe

  3. Humidification tower for humid air gas turbine cycles: Experimental analysis

    International Nuclear Information System (INIS)

    Traverso, A.

    2010-01-01

    In the HAT (humid air turbine) cycle, the humidification of compressed air can be provided by a pressurised saturator (i.e. humidification tower or saturation tower), this solution being known to offer several attractive features. This work is focused on an experimental study of a pressurised humidification tower, with structured packing. After a description of the test rig employed to carry out the measuring campaign, the results relating to the thermodynamic process are presented and discussed. The experimental campaign was carried out over 162 working points, covering a relatively wide range of possible operating conditions. It is shown that the saturator behaviour, in terms of air outlet humidity and temperature, is primarily driven by, in decreasing order of relevance, the inlet water temperature, the inlet water over inlet dry air mass flow ratio and the inlet air temperature. The exit relative humidity is consistently over 100%, which may be explained partially by measurement accuracy and droplet entrainment, and partially by the non-ideal behaviour of air-steam mixtures close to saturation. Experimental results have been successfully correlated using a set of new non-dimensional groups: such a correlation is able to capture the air outlet temperature with a standard deviation σ = 2.8 K.

  4. Experimental analysis of humidification process by air passing through seawater

    International Nuclear Information System (INIS)

    El-Agouz, S.A.; Abugderah, M.

    2008-01-01

    An experimental investigation of humidification process by air passing through seawater is presented. The main objective of this work was to determine the humid air behaviour through single-stage of heating-humidifying processes. This experimental work studied the influence of the operating conditions such as the water temperature, the headwater difference, the air velocity and the inlet air temperature to evaporator chamber on the vapour content difference and humidification efficiency. Two cases of different inlet conditions of ambient and heated air cases are studied. The experimental results show that, the vapour content difference and the humidification efficiency of the system is strongly affected by the saline water temperature in the evaporator chamber, headwater difference and the air velocity. The inlet air temperature to evaporator chamber variation was found to have a small affect on the vapour content difference. The obtained maximum vapour content difference of the air was about 222 gr w /kg a at 75 deg. C for water and air. The obtained vapour content is high compared to that obtained in literature for single-stage and very similar for multi-stage

  5. Sensible Heat Transfer during Droplet Cooling: Experimental and Numerical Analysis

    Directory of Open Access Journals (Sweden)

    Emanuele Teodori

    2017-06-01

    Full Text Available This study presents the numerical reproduction of the entire surface temperature field resulting from a water droplet spreading on a heated surface, which is compared with experimental data. High-speed infrared thermography of the back side of the surface and high-speed images of the side view of the impinging droplet were used to infer on the solid surface temperature field and on droplet dynamics. Numerical reproduction of the phenomena was performed using OpenFOAM CFD toolbox. An enhanced volume of fluid (VOF model was further modified for this purpose. The proposed modifications include the coupling of temperature fields between the fluid and the solid regions, to account for transient heat conduction within the solid. The results evidence an extremely good agreement between the temporal evolution of the measured and simulated spreading factors of the considered droplet impacts. The numerical and experimental dimensionless surface temperature profiles within the solid surface and along the droplet radius, were also in good agreement. Most of the differences were within the experimental measurements uncertainty. The numerical results allowed relating the solid surface temperature profiles with the fluid flow. During spreading, liquid recirculation within the rim, leads to the appearance of different regions of heat transfer that can be correlated with the vorticity field within the droplet.

  6. Fission Product Experimental Program: Validation and Computational Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Leclaire, N.; Ivanova, T.; Letang, E. [Inst Radioprotect and Surete Nucl, F-92262 Fontenay Aux Roses (France); Girault, E. [CEA Valduc, Serv Rech Neutron and Critcite, 21 - Is-sur-Tille (France); Thro, J. F. [AREVA NC, F-78000 Versailles (France)

    2009-02-15

    From 1998 to 2004, a series of critical experiments referred to as the fission product (FP) experimental program was performed at the Commissariat a l'Energie Atomique Valduc research facility. The experiments were designed by Institut de Radioprotection et de Surete Nucleaire (IRSN) and funded by AREVA NC and IRSN within the French program supporting development of a technical basis for burnup credit validation. The experiments were performed with the following six key fission products encountered in solution either individually or as mixtures: {sup 103}Rh, {sup 133}Cs, {sup nat}Nd, {sup 149}Sm, {sup 152}Sm, and {sup 155}Gd. The program aimed at compensating for the lack of information on critical experiments involving FPs and at establishing a basis for FPs credit validation. One hundred forty-five critical experiments were performed, evaluated, and analyzed with the French CRISTAL criticality safety package and the American SCALE5. 1 code system employing different cross-section libraries. The aim of the paper is to show the experimental data potential to improve the ability to perform validation of full burnup credit calculation. The paper describes three Phases of the experimental program; the results of preliminary evaluation, the calculation, and the sensitivity/uncertainty study of the FP experiments used to validate the APOLLO2-MORET 4 route in the CRISTAL criticality package for burnup credit applications. (authors)

  7. Application of descriptive statistics in analysis of experimental data

    OpenAIRE

    Mirilović Milorad; Pejin Ivana

    2008-01-01

    Statistics today represent a group of scientific methods for the quantitative and qualitative investigation of variations in mass appearances. In fact, statistics present a group of methods that are used for the accumulation, analysis, presentation and interpretation of data necessary for reaching certain conclusions. Statistical analysis is divided into descriptive statistical analysis and inferential statistics. The values which represent the results of an experiment, and which are the subj...

  8. ANALYSIS OF EXCHANGE RATE LINKED SUBSIDIES FOR NON-PRICE EXPORT PROMOTION: THE CASE OF COTTON

    OpenAIRE

    Paudel, Laxmi; Adhikari, Murali; Houston, Jack E.; Kinnucan, Henry W.

    2002-01-01

    An equilibrium displacement framework was developed to evaluate the effect of exchange rate linked subsidies for non-price export promotion for US cotton. Study results show that an increase in promotion expenditure increased the dollar value and producer welfare of cotton growers. The gross gain to the domestic cotton producers from the exchange-rate linked subsidy scheme was positive. These evidences support exchange rate linked subsidies for US cotton export promotion.

  9. Linking dynamic phenotyping with metabolite analysis to study natural variation in drought responses of Brachypodium distachyon

    Directory of Open Access Journals (Sweden)

    Lorraine H.C. Fisher

    2016-11-01

    Full Text Available Drought is an important environmental stress limiting the productivity of major crops worldwide. Understanding drought tolerance and possible mechanisms for improving drought resistance is therefore a prerequisite to develop drought-tolerant crops that produce significant yields with reduced amounts of water. Brachypodium distachyon (Brachypodium is a key model species for cereals, forage grasses and energy grasses. In this study, initial screening of a Brachypodium germplasm collection consisting of 138 different ecotypes exposed to progressive drought, highlighted the natural variation in morphology, biomass accumulation and responses to drought stress. A core set of ten ecotypes, classified as being either tolerant, susceptible or intermediate, in response to drought stress, were exposed to mild or severe (respectively 15% and 0% soil water content drought stress and phenomic parameters linked to growth and colour changes were assessed. When exposed to severe drought stress, phenotypic data and metabolite profiling combined with multivariate analysis revealed a remarkable consistency in separating the selected ecotypes into their different pre-defined drought tolerance groups. Increases in several metabolites, including for the phytohormones jasmonic acid and salicylic acid, and TCA-cycle intermediates, were positively correlated with biomass yield and with reduced yellow pixel counts; suggestive of delayed senescence, both key target traits for crop improvement to drought stress. While metabolite analysis also separated ecotypes into the distinct tolerance groupings after exposure to mild drought stress, similar analysis of the phenotypic data failed to do so, confirming the value of metabolomics to investigate early responses to drought stress. The results highlight the potential of combining the analyses of phenotypic and metabolic responses to identify key mechanisms and markers associated with drought tolerance in both the Brachypodium

  10. Economic analysis of the daylight-linked lighting control system in office buildings

    Energy Technology Data Exchange (ETDEWEB)

    Yang, In-Ho; Nam, Eun-Ji [Department of Architectural Engineering, College of Engineering, Dongguk University, 26-3, Pil-dong, Chung-gu, Seoul 100-715 (Korea)

    2010-08-15

    The objective of this study is to perform an economic analysis of the daylight-linked automatic on/off lighting control system installed for the purpose of energy savings in office buildings. For this, a building was chosen as a typical example, and the energy cost was calculated by using the daylight and building energy analysis simulation. When the lighting control was utilized, an economic analysis was performed using a payback period that was calculated by comparing the initial cost of installing the lighting control system with the annual energy cost which was reduced thanks to the application of the lighting control. The results showed that the lighting energy consumption, when the lighting control was applied, was reduced by an average of 30.5% compared with the case that there was not lighting control applied. Also, the result for total energy consumption showed that, when lighting control was applied, this was reduced by 8.5% when the glazing ratio was 100%, 8.2% for 80%, and 7.6% for 60% when compared to non-application. The payback period was analyzed in terms of the number of floors in a building; 10 floors, 20 floors, 30 floors, and 40 floors. Hence, the building with 40 floors and glazing ratio 100% resulted in the shortest payback period of 8.8 years, the building with 10 floors and glazing ratio 60% resulted in the longest period of 12.7 years. In other words, the larger the glazing ratio and the number of building floors are, the shorter the payback period is. (author)

  11. CLIPZ: a database and analysis environment for experimentally determined binding sites of RNA-binding proteins.

    Science.gov (United States)

    Khorshid, Mohsen; Rodak, Christoph; Zavolan, Mihaela

    2011-01-01

    The stability, localization and translation rate of mRNAs are regulated by a multitude of RNA-binding proteins (RBPs) that find their targets directly or with the help of guide RNAs. Among the experimental methods for mapping RBP binding sites, cross-linking and immunoprecipitation (CLIP) coupled with deep sequencing provides transcriptome-wide coverage as well as high resolution. However, partly due to their vast volume, the data that were so far generated in CLIP experiments have not been put in a form that enables fast and interactive exploration of binding sites. To address this need, we have developed the CLIPZ database and analysis environment. Binding site data for RBPs such as Argonaute 1-4, Insulin-like growth factor II mRNA-binding protein 1-3, TNRC6 proteins A-C, Pumilio 2, Quaking and Polypyrimidine tract binding protein can be visualized at the level of the genome and of individual transcripts. Individual users can upload their own sequence data sets while being able to limit the access to these data to specific users, and analyses of the public and private data sets can be performed interactively. CLIPZ, available at http://www.clipz.unibas.ch, aims to provide an open access repository of information for post-transcriptional regulatory elements.

  12. Optimization of Formaldehyde Cross-Linking for Protein Interaction Analysis of Non-Tagged Integrin β1

    Directory of Open Access Journals (Sweden)

    Cordula Klockenbusch

    2010-01-01

    Full Text Available Formaldehyde cross-linking of protein complexes combined with immunoprecipitation and mass spectrometry analysis is a promising technique for analysing protein-protein interactions, including those of transient nature. Here we used integrin β1 as a model to describe the application of formaldehyde cross-linking in detail, particularly focusing on the optimal parameters for cross-linking, the detection of formaldehyde cross-linked complexes, the utility of antibodies, and the identification of binding partners. Integrin β1 was found in a high molecular weight complex after formaldehyde cross-linking. Eight different anti-integrin β1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed. However, two of the antibodies could not precipitate the complex, probably due to hidden epitopes. Formaldehyde cross-linked complexes, precipitated from Jurkat cells or human platelets and analyzed by mass spectrometry, were found to be composed of integrin β1, α4 and α6 or β1, α6, α2, and α5, respectively.

  13. Optimization of Formaldehyde Cross-Linking for Protein Interaction Analysis of Non-Tagged Integrin β1

    Science.gov (United States)

    Klockenbusch, Cordula; Kast, Juergen

    2010-01-01

    Formaldehyde cross-linking of protein complexes combined with immunoprecipitation and mass spectrometry analysis is a promising technique for analysing protein-protein interactions, including those of transient nature. Here we used integrin β1 as a model to describe the application of formaldehyde cross-linking in detail, particularly focusing on the optimal parameters for cross-linking, the detection of formaldehyde cross-linked complexes, the utility of antibodies, and the identification of binding partners. Integrin β1 was found in a high molecular weight complex after formaldehyde cross-linking. Eight different anti-integrin β1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed. However, two of the antibodies could not precipitate the complex, probably due to hidden epitopes. Formaldehyde cross-linked complexes, precipitated from Jurkat cells or human platelets and analyzed by mass spectrometry, were found to be composed of integrin β1, α4 and α6 or β1, α6, α2, and α5, respectively. PMID:20634879

  14. Experimental analysis of a paraffin-based cold storage tank

    OpenAIRE

    Barbara Torregrosa-Jaime; López-Navarro, Alejandro; Corberán, José M.; Esteban-Matías, J. C.; Klinkner, L.; Payá-Herrero, Jorge

    2013-01-01

    [EN] The aim of this study is to characterize a paraffin-based cold storage tank. Novel experimental results are presented for this system which combines a significant amount of paraffin (1450 kg) immersed around 18 spiral-shaped coils disposed in counter-current flow. The paraffin has a phase-change temperature in the range 4 8 °C as measured by a 3-layer calorimeter. Different tests have been carried out with a constant mass flow rate and supply temperature. Around 31% of the paraffin has h...

  15. Theoretical and experimental analysis of fast reactor fuel performance

    International Nuclear Information System (INIS)

    Kummerer, K.R.; Freund, D.; Steiner, H.

    1982-09-01

    In order to predict behavior, performance, and capability of prototypic fuel pins a standard operational scheme for the SNR-300 fast breeder reactor is established considering besides normal operation unscheduled power changes and shutdowns. The behavior during the whole lifetime is calculated using the updated SATURN codes and - for special conditions as power transients and skewed fuel rod power - the new TRANSIENT and TEXDIF codes. The results of these calculations are compared to experimental findings. It is demonstrated that the level of modeling and the knowledge of material properties under irradiation are sufficient for a quantitative description of the fuel pin performance under the above mentioned conditions. (orig.) [de

  16. Compensation schemes, liquidity provision, and asset prices: An experimental analysis

    OpenAIRE

    Baghestanian, Sascha; Gortner, Paul; Massenot, Baptiste

    2015-01-01

    In an experimental setting in which investors can entrust their money to traders, we investigate how compensation schemes affect liquidity provision and asset prices. Investors face a trade-off between risk and return. At the benefit of a potentially higher return, they can entrust their money to a trader. However this investment is risky, as the trader might not be trustworthy. Alternatively, they can opt for a safe but low return. We study how subjects solve this trade-off when traders are ...

  17. Experimental and numerical analysis of the drainage of aluminium foams

    International Nuclear Information System (INIS)

    Brunke, O; Hamann, A; Cox, S J; Odenbach, S

    2005-01-01

    Drainage is one of the driving forces for the temporal instability of molten metal foams. For usual aqueous foams this phenomenon is well examined and understood on both the experimental and the theoretical side. The situation is different for metallic foams. Due to their opaque nature, the observation of drainage is only possible by either measuring the density distribution of solidified samples ex situ or by x-ray or neutron radioscopy. Up to now there exists just one theoretical study describing the drainage behaviour of metallic foams incorporating the drainage equation, the temperature dependence of the viscosity and thermal transport. This paper will present results on the drainage behaviour of aluminium foams grown by a powder-metallurgical production route. For this purpose an experiment which allows the observation of drainage in cylindrical metal foam columns has been developed. Experimental density profiles after different drainage times are measured ex situ and compared to numerical results of the standard drainage equation for aqueous foams. This first comparison between the density redistribution of metallic aluminium foams and numerical solutions shows that the standard drainage equation can be used to explain the drainage behaviour of metallic foams

  18. Experimental Investigation and Analysis of an Annular Pogo Accumulator

    Science.gov (United States)

    Peugeot, John; Schwarz, Jordan; Yang, H. Q.; Zoladz, Tom

    2011-01-01

    An experimental investigation was conducted on a scaled annular pogo accumulator for the Ares I Upper Stage. The test article was representative of the LO2 feedline and preliminary accumulator design, and included multiple designs of a perforated ring connecting the accumulator to the core feedline flow. The system was pulse tested in water over a range of pulse frequency and flow rates. Time dependent measurements of pressure at various locations in the test article were used to extract system compliance, inertance, and resistance. Preliminary results indicated a significant deviation from standard orifice flow theory and suggest a strong dependence on feedline average velocity. In addition, several CFD analyses were conducted to investigate the details of the time variant flow field. Both two-dimensional and three-dimensional simulations were performed with time varying boundary conditions used to represent system pulsing. The CFD results compared well with the sub-scale results and demonstrated the influence of feedline average velocity on the flow into and out of the accumulator. This paper presents updated results of the investigation including a parametric design space for determining resistance characteristics. Using the updated experimental results a new scaling relationship has been defined for shear flow over a cavity. A comparison of sub-scale and full scale CFD simulations provided early verification of the scaling of the fluid flowfield and resistance characteristics.

  19. A Short Guide to Experimental Design and Analysis for Engineers

    Science.gov (United States)

    2014-04-01

    2011) Statistical Analysis: Microsoft Excel 2010. Indianapolis, Que Publishing Coakes, S. J. and Ong, C. (2011) SPSS : Analysis without Anguish ...of 0. UNCLASSIFIED DSTO-TN-1291 UNCLASSIFIED 24 Figure 6: Box and whisker plot of the batch data produced with SPSS . A closer look at Figure...Smirnov and Shapiro-Wilk statistics is used to confirm this requirement (Coakes and Ong, 2011). Employing SPSS produces significance values of 0.2

  20. Variables As Currency: Linking Meta-Analysis Research and Data Paths in Sciences

    Directory of Open Access Journals (Sweden)

    Hua Qin

    2014-11-01

    Full Text Available Meta-analyses are studies that bring together data or results from multiple independent studies to produce new and over-arching findings. Current data curation systems only partially support meta-analytic research. Some important meta-analytic tasks, such as the selection of relevant studies for review and the integration of research datasets or findings, are not well supported in current data curation systems. To design tools and services that more fully support meta-analyses, we need a better understanding of meta-analytic research. This includes an understanding of both the practices of researchers who perform the analyses and the characteristics of the individual studies that are brought together. In this study, we make an initial contribution to filling this gap by developing a conceptual framework linking meta-analyses with data paths represented in published articles selected for the analysis. The framework focuses on key variables that represent primary/secondary datasets or derived socio-ecological data, contexts of use, and the data transformations that are applied. We introduce the notion of using variables and their relevant information (e.g., metadata and variable relationships as a type of currency to facilitate synthesis of findings across individual studies and leverage larger bodies of relevant source data produced in small science research. Handling variables in this manner provides an equalizing factor between data from otherwise disparate data-producing communities. We conclude with implications for exploring data integration and synthesis issues as well as system development.

  1. Cost-Benefit Analysis of High-Speed Rail Link between Hong Kong and Mainland China

    Directory of Open Access Journals (Sweden)

    R. Tao

    2011-07-01

    Full Text Available The Legislative Council in Hong Kong has approved a funding of USD$8.60 billion to build the high-speed rail (HSR line linking mainland China. HSR is a break-through technology that allows trains running at a speed over 250 km per hour. The most controversial part of the HSR investment is whether its cost could be compensated by the social benefits. In this study, a cost-benefit analysis of the Hong Kong to mainland HSR (HKM-HSR line is carried out. First, all the direct and indirect costs, and social benefits are defined; then, monetary equivalents are assigned to these elements; third, all the future values are discounted into present values and aggregated. The results show that the project has a positive net present value (NPV up to USD$2,068.49 million, which proves that the investment is worth. In addition, other transport alternatives, i.e. the existing roadway and conventional railway, are examined and compared with HKM-HSR, which unveils that HSR has the largest positive NPV among these three passenger transportation modes because of its excellent performance in ticket revenue, travel time savings and safety improvement.

  2. Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites.

    Science.gov (United States)

    Sakamoto, Seiichi; Putalun, Waraporn; Vimolmangkang, Sornkanok; Phoolcharoen, Waranyoo; Shoyama, Yukihiro; Tanaka, Hiroyuki; Morimoto, Satoshi

    2018-01-01

    Immunoassays are antibody-based analytical methods for quantitative/qualitative analysis. Since the principle of immunoassays is based on specific antigen-antibody reaction, the assays have been utilized worldwide for diagnosis, pharmacokinetic studies by drug monitoring, and the quality control of commercially available products. Berson and Yalow were the first to develop an immunoassay, known as radioimmunoassay (RIA), for detecting endogenous plasma insulin [1], a development for which Yalow was awarded the Nobel Prize in Physiology or Medicine in 1977. Even today, after half a century, immunoassays are widely utilized with some modifications from the originally proposed system, e.g., radioisotopes have been replaced with enzymes because of safety concerns regarding the use of radioactivity, which is referred to as enzyme immunoassay/enzyme-linked immunosorbent assay (ELISA). In addition, progress has been made in ELISA with the recent advances in recombinant DNA technology, leading to increase in the range of antibodies, probes, and even systems. This review article describes ELISA and its applications for the detection of plant secondary metabolites.

  3. A Network Analysis Perspective to Implementation: The Example of Health Links to Promote Coordinated Care.

    Science.gov (United States)

    Yousefi Nooraie, Reza; Khan, Sobia; Gutberg, Jennifer; Baker, G Ross

    2018-01-01

    Although implementation models broadly recognize the importance of social relationships, our knowledge about applying social network analysis (SNA) to formative, process, and outcome evaluations of health system interventions is limited. We explored applications of adopting an SNA lens to inform implementation planning, engagement and execution, and evaluation. We used Health Links, a province-wide program in Canada aiming to improve care coordination among multiple providers of high-needs patients, as an example of a health system intervention. At the planning phase, an SNA can depict the structure, network influencers, and composition of clusters at various levels. It can inform the engagement and execution by identifying potential targets (e.g., opinion leaders) and by revealing structural gaps and clusters. It can also be used to assess the outcomes of the intervention, such as its success in increasing network connectivity; changing the position of certain actors; and bridging across specialties, organizations, and sectors. We provided an overview of how an SNA lens can shed light on the complexity of implementation along the entire implementation pathway, by revealing the relational barriers and facilitators, the application of network-informed and network-altering interventions, and testing hypotheses on network consequences of the implementation.

  4. Damage evolution analysis of coal samples under cyclic loading based on single-link cluster method

    Science.gov (United States)

    Zhang, Zhibo; Wang, Enyuan; Li, Nan; Li, Xuelong; Wang, Xiaoran; Li, Zhonghui

    2018-05-01

    In this paper, the acoustic emission (AE) response of coal samples under cyclic loading is measured. The results show that there is good positive relation between AE parameters and stress. The AE signal of coal samples under cyclic loading exhibits an obvious Kaiser Effect. The single-link cluster (SLC) method is applied to analyze the spatial evolution characteristics of AE events and the damage evolution process of coal samples. It is found that a subset scale of the SLC structure becomes smaller and smaller when the number of cyclic loading increases, and there is a negative linear relationship between the subset scale and the degree of damage. The spatial correlation length ξ of an SLC structure is calculated. The results show that ξ fluctuates around a certain value from the second cyclic loading process to the fifth cyclic loading process, but spatial correlation length ξ clearly increases in the sixth loading process. Based on the criterion of microcrack density, the coal sample failure process is the transformation from small-scale damage to large-scale damage, which is the reason for changes in the spatial correlation length. Through a systematic analysis, the SLC method is an effective method to research the damage evolution process of coal samples under cyclic loading, and will provide important reference values for studying coal bursts.

  5. Analysis of protein-nucleic acid interactions by photochemical cross-linking and mass spectrometry

    DEFF Research Database (Denmark)

    Steen, Hanno; Jensen, Ole Nørregaard

    2002-01-01

    . Mass spectrometry (MS) has emerged as a sensitive and efficient analytical technique for determination of such cross-linking sites in proteins. The present review of the field describes a number of MS-based approaches for the characterization of cross-linked protein-nucleic acid complexes...

  6. Analysis of voltage modulation based active damping techniques for small DC-link drive system

    DEFF Research Database (Denmark)

    Wang, Dong; Lu, Kaiyuan; Rasmussen, Peter Omand

    2015-01-01

    Small DC-link drive system, built with film capacitor in the DC link, may have the advantages of longer lifetime and the possibility to achieve a more compact design of capacitor bank at medium and high power rates. However, it exhibits instability problem, especially when it is fed by a soft grid...

  7. Autoradiographic analysis of iodoamphetamine redistribution in experimental brain ischemia

    International Nuclear Information System (INIS)

    Matsuda, H.; Tsuji, S.; Oba, H.; Shiba, K.; Terada, H.; Kinuya, K.; Mori, H.; Sumiya, H.; Hisada, K.

    1990-01-01

    The pathophysiologic significance of iodoamphetamine (IMP) redistribution was analyzed using a double radionuclide autoradiography technique in experimental brain ischemia in the rat. Within 4 hr after unilateral arterial occlusion, IMP almost completely redistributed at 150 min postinjection in the affected areas. At 2 min postinjection, both a remarkable decrease of IMP accumulation and histopathologic change of diminished staining were observed in these areas. The redistribution amplitude was higher in the affected hemisphere, especially in the regions surrounding the ischemic core than in the unaffected hemisphere. These findings were consistent with computer simulation studies of the time course of brain activity based on the standard diffusible tracer model. The results suggest that IMP redistribution in the ischemic area is due to differences of the temporal changes of the brain activity between the unaffected and affected areas and that it is a physical phenomenon (only flow related) rather than a biologic one

  8. Numerical and experimental analysis of a solid desiccant wheel

    Directory of Open Access Journals (Sweden)

    Koronaki Irene P.

    2016-01-01

    Full Text Available The rotary desiccant dehumidifier is an important component which can be used in air conditioning systems in order to reduce the electrical energy consumption and introduce renewable energy sources. In this study a one dimensional gas side resistance model is presented for predicting the performance of the desiccant wheel. Measurements from two real sorption wheels are used in order to validate the model. One wheel uses silica gel as desiccant material and the other lithium chloride. The simulation results are in good agreement with the experimental data. The model is used to compare the counter flow with the co-current wheel arrangements and to explain why the counter flow one is more efficient for air dehumidification.

  9. Experimental analysis of nonlinear oscillations in the undergraduate physics laboratory

    International Nuclear Information System (INIS)

    Moreno, R; Page, A; Riera, J; Hueso, J L

    2014-01-01

    In this paper, we present a simple experiment to introduce the nonlinear behaviour of oscillating systems in the undergraduate physics laboratory. The transverse oscillations of a spring allow reproduction of three totally different scenarios: linear oscillations, nonlinear oscillations reducible to linear for small displacements, and intrinsically nonlinear oscillations. The chosen approach consists of measuring the displacements using video photogrammetry and computing the velocities and the accelerations by means of a numerical differentiation algorithm. In this way, one can directly check the differential equation of the motion without having to integrate it, or perform an experimental study of the potential energy in each of the analysed scenarios. This experiment allows first year students to reflect on the consequences and the limits of the linearity assumption for small displacements that is so often made in technical studies. (paper)

  10. Experimental vibration level analysis of a Francis turbine

    International Nuclear Information System (INIS)

    Bucur, D M; Dunca, G; Calinoiu, C

    2012-01-01

    In this study the vibration level of a Francis turbine is investigated by experimental work in site. Measurements are carried out for different power output values, in order to highlight the influence of the operation regimes on the turbine behavior. The study focuses on the turbine shaft to identify the mechanical vibration sources and on the draft tube in order to identify the hydraulic vibration sources. Analyzing the vibration results, recommendations regarding the operation of the turbine, at partial load close to minimum values, in the middle of the operating domain or close to maximum values of electric power, can be made in order to keep relatively low levels of vibration. Finally, conclusions are drawn in order to present the real sources of the vibrations.

  11. Experimental analysis of green roof substrate detention characteristics.

    Science.gov (United States)

    Yio, Marcus H N; Stovin, Virginia; Werdin, Jörg; Vesuviano, Gianni

    2013-01-01

    Green roofs may make an important contribution to urban stormwater management. Rainfall-runoff models are required to evaluate green roof responses to specific rainfall inputs. The roof's hydrological response is a function of its configuration, with the substrate - or growing media - providing both retention and detention of rainfall. The objective of the research described here is to quantify the detention effects due to green roof substrates, and to propose a suitable hydrological modelling approach. Laboratory results from experimental detention tests on green roof substrates are presented. It is shown that detention increases with substrate depth and as a result of increasing substrate organic content. Model structures based on reservoir routing are evaluated, and it is found that a one-parameter reservoir routing model coupled with a parameter that describes the delay to start of runoff best fits the observed data. Preliminary findings support the hypothesis that the reservoir routing parameter values can be defined from the substrate's physical characteristics.

  12. A numerical analysis of the British Experimental Rotor Program blade

    Science.gov (United States)

    Duque, Earl P. N.

    1989-01-01

    Two Computational Fluid Dynamic codes which solve the compressible full-potential and the Reynolds-Averaged Thin-Layer Navier-Stokes equations were used to analyze the nonrotating aerodynamic characteristics of the British Experimental Rotor Program (BERP) helicopter blade at three flow regimes: low angle of attack, high angle of attack and transonic. Excellent agreement was found between the numerical results and experiment. In the low angle of attack regime, the BERP had less induced drag than a comparable aspect ratio rectangular planform wing. At high angle of attack, the blade attained high-lift by maintaining attached flow at the outermost spanwise locations. In the transonic regime, the BERP design reduces the shock strength at the outer spanwise locations which affects wave drag and shock-induced separation. Overall, the BERP blade exhibited many favorable aerodynamic characteristics in comparison to conventional helicopter rotor blades.

  13. Experimental damage analysis of steels after exploitation loading

    Directory of Open Access Journals (Sweden)

    B. Augustyniak

    2010-06-01

    Full Text Available Development of creep damage at elevated temperatures and structural degradation due to plastic deformation at room temperature were assessed using destructive and non-destructive methods in steels commonly applied in power plants (40HNMA, 13HMF and P91. As destructive methods the standard tension tests were carried out after every kind of prestraining. Subsequently, an evolution of the selected tension parameters was taken into account for damage identification. In order to assess a damage development during the creep and plastic deformation the tests for the steels were interrupted for a range of the selected strain magnitudes. The ultrasonic and magnetic techniques were used as the non-destructive methods for damage evaluation. The experimental programme also contained microscopic observations.

  14. An experimental approach to free vibration analysis of smart composite beam

    Science.gov (United States)

    Yashavantha Kumar, G. A.; Sathish Kumar, K. M.

    2018-02-01

    Experimental vibration analysis is a main concern of this study. In designing any structural component the important parameter that has to be considered is vibration. The present work involves the experimental investigation of free vibration analysis of a smart beam. Smart beam consists of glass/epoxy composite as a main substrate and two PZT patches. The PZT patches are glued above and below the main beam. By experimentation the natural frequencies and mode shapes are obtained for both with and without PZT patches of a beam. Finally through experimentation the response of the smart beam is recorded.

  15. Experimental transport analysis code system in JT-60

    International Nuclear Information System (INIS)

    Hirayama, Toshio; Shimizu, Katsuhiro; Tani, Keiji; Shirai, Hiroshi; Kikuchi, Mitsuru

    1988-03-01

    Transport analysis codes have been developed in order to study confinement properties related to particle and energy balance in ohmically and neutral beam heated plasmas of JT-60. The analysis procedure is divided into three steps as follows: 1) LOOK ; The shape of the plasma boundary is identified with a fast boundary identification code of FBI by using magnetic data, and flux surfaces are calculated with a MHD equilibrium code of SELENE. The diagnostic data are mapped to flux surfaces for neutral beam heating calculation and/or for radial transport analysis. 2) OFMC ; On the basis of transformed data, an orbit following Monte Carlo code of OFMC calculates both profiles of power deposition and particle source of neutral beam injected into a plasma. 3) SCOOP ; In the last stage, a one dimensional transport code of SCOOP solves particle and energy balance for electron and ion, in order to evaluate transport coefficients as well as global parameters such as energy confinement time and the stored energy. The analysis results are provided to a data bank of DARTS that is used to find an overview of important consideration on confinement with a regression analysis code of RAC. (author)

  16. Theoretical and Experimental Analysis of Fast Neutron Spectra

    Energy Technology Data Exchange (ETDEWEB)

    Van Dam, H.; Kleijn, H. R. [Reactor Instituut, Delft (Netherlands)

    1968-04-15

    The reactor physics division of the Inter-Academic Reactor Institute at Delft is concentrating its efforts in the field of fast reactor physics on problems of a more fundamental nature. The object of the programme is to determine experimentally a number of microscopic reactor physics parameters such as conversion potentials, fission ratios and Doppler coefficients for simple geometries and material compositions. Because of the extreme importance of knowledge of the neutron spectrum for the interpretation of the results, attention has initially been concentrated on both the measurement and the calculation of fast neutron spectra. The transport of neutrons in absorbing and non-absorbing heavy atom materials is studied by solving the Boltzmann equation. Both isotropic and anisotropic scattering are considered. Anisotropic scattering is treated by the P{sub n}-approximation, while flux-anisotropy is handled with the S{sub N}-method. In the code FAST-DELFT, scattering is treated up to the P{sub 4} component, a further extension of which is useless because of the lack of available cross-section data. By using this method, the effect of scattering anisotropy on the spectrum formation has been studied. In addition the influence of group cross-section inaccuracies was determined. The experimental work has been concentrated on methods to determine in-core spectra. Using home-made proportional counters with gamma-ray discrimination provisions fast neutron spectra have been measured in simple geometries. These experiments were complemented by foil measurements in the lower energy region. The results of this work are presented in this paper. (author)

  17. Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

    Directory of Open Access Journals (Sweden)

    Harold Tjalsma

    Full Text Available The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1 and its paralogue Hepcidin-2 (Hep-2 at the peptide level. To this purpose, Fourier transform ion cyclotron resonance (FTICR and tandem-MS was used for hepcidin identification, after which a time-of-flight (TOF MS-based methodology was exploited to routinely determine Hep-1 and -2 levels in mouse serum and urine. This method was biologically validated by hepcidin assessment in: i 3 mouse strains (C57Bl/6; DBA/2 and BABL/c upon stimulation with intravenous iron and LPS, ii homozygous Hfe knock out, homozygous transferrin receptor 2 (Y245X mutated mice and double affected mice, and iii mice treated with a sublethal hepatotoxic dose of paracetamol. The results showed that detection of Hep-1 was restricted to serum, whereas Hep-2 and its presumed isoforms were predominantly present in urine. Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains. Serum Hep-1 was decreased in all three hemochromatosis models, being lowest in the double affected mice. Serum Hep-1 levels correlated with liver hepcidin-1 gene expression, while acute liver damage by paracetamol depleted Hep-1 from serum. Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation. In conclusion, Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators, and their measurement can now be implemented in experimental mouse models to provide novel insights in post-transcriptional regulation, hepcidin function, and kinetics.

  18. Analytical analysis and experimental verification of interleaved parallelogram heat sink

    International Nuclear Information System (INIS)

    Chen, Hong-Long; Wang, Chi-Chuan

    2017-01-01

    Highlights: • A novel air-cooled heat sink profile (IPFM) is proposed to compete with the typical design. • It features two different perimeters with odd fin being rectangular and the rest being parallelogram. • A new modified dimensionless parameter characterized the flow length in triangular region is proposed. • The analytical predictions are in line with the experiments for both conventional and IPFM design. • IPFM design shows a much lower pressure drop and a superior performance especially for dense fins. - Abstract: In this study, a novel air-cooled heat sink profile is proposed to compete with the conventional design. The new design is termed as IPFM (Interleaved Parallelogram Fin Module) which features two different geometrical perimeter shapes of fins. This new design not only gains the advantage of lower pressure drop for power saving; but also gains a material saving for less fin surface area. An assessment of flow impedance and performance between the conventional and IPFM heat sink is analytically investigated and experimentally verified. A new modified dimensionless friction factor for triangular region is proposed. The analytical predictions agree with experimental measurements for both conventional and IPFM design. In electronic cooling design, especially for cloud server air-cooled heat sink design, the flow pattern is usually laminar with Reynolds number being operated less than 2000. In this regime, the IPFM design shows 8–12% less of surface than conventional design when the flow rate is less than 10 CFM; yet the thermal performance is slightly inferior to the conventional design when the flowrate is raised towards 25 CFM. Yet in the test range of 5–25 CFM, a 10–15% lower flow impedance is observed. The smaller fin spacing, the more conspicuous reduction of flow impedance is observed. The optimization of cutting angle is around 35° for 10 CFM, and it is reduced to 15° at a larger flowrate of 20 CFM.

  19. Analysis of spastic gait in cervical myelopathy: Linking compression ratio to spatiotemporal and pedobarographic parameters.

    Science.gov (United States)

    Nagai, Taro; Takahashi, Yasuhito; Endo, Kenji; Ikegami, Ryo; Ueno, Ryuichi; Yamamoto, Kengo

    2018-01-01

    Gait dysfunction associated with spasticity and hyperreflexia is a primary symptom in patients with compression of cervical spinal cord. The objective of this study was to link maximum compression ratio (CR) to spatiotemporal/pedobarographic parameters. Quantitative gait analysis was performed by using a pedobarograph in 75 elderly males with a wide range of cervical compression severity. CR values were characterized on T1-weighted magnetic resonance imaging (MRI). Statistical significances in gait analysis parameters (speed, cadence, stride length, step with, and toe-out angle) were evaluated among different CR groups by the non-parametric Kruskal-Wallis test followed by the Mann-Whitney U test using Bonferroni correction. The Spearman test was performed to verify correlations between CR and gait parameters. The Kruskal-Wallis test revealed significant decline in gait speed and stride length and significant increase in toe-out angle with progression of cervical compression myelopathy. The post-hoc Mann-Whitney U test showed significant differences in these parameters between the control group (0.45test revealed that CR was significantly correlated with speed, cadence, stride length, and toe-out angle. Gait speed, stride length, and toe-out angle can serve as useful indexes for evaluating progressive gait abnormality in cervical myelopathy. Our findings suggest that CR≤0.25 is associated with significantly poorer gait performance. Nevertheless, future prospective studies are needed to determine a potential benefit from decompressive surgery in such severe compression patients. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Automatic Decision Support for Clinical Diagnostic Literature Using Link Analysis in a Weighted Keyword Network.

    Science.gov (United States)

    Li, Shuqing; Sun, Ying; Soergel, Dagobert

    2017-12-23

    We present a novel approach to recommending articles from the medical literature that support clinical diagnostic decision-making, giving detailed descriptions of the associated ideas and principles. The specific goal is to retrieve biomedical articles that help answer questions of a specified type about a particular case. Based on the filtered keywords, MeSH(Medical Subject Headings) lexicon and the automatically extracted acronyms, the relationship between keywords and articles was built. The paper gives a detailed description of the process of by which keywords were measured and relevant articles identified based on link analysis in a weighted keywords network. Some important challenges identified in this study include the extraction of diagnosis-related keywords and a collection of valid sentences based on the keyword co-occurrence analysis and existing descriptions of symptoms. All data were taken from medical articles provided in the TREC (Text Retrieval Conference) clinical decision support track 2015. Ten standard topics and one demonstration topic were tested. In each case, a maximum of five articles with the highest relevance were returned. The total user satisfaction of 3.98 was 33% higher than average. The results also suggested that the smaller the number of results, the higher the average satisfaction. However, a few shortcomings were also revealed since medical literature recommendation for clinical diagnostic decision support is so complex a topic that it cannot be fully addressed through the semantic information carried solely by keywords in existing descriptions of symptoms. Nevertheless, the fact that these articles are actually relevant will no doubt inspire future research.

  1. Linking cases of illegal shootings of the endangered California condor using stable lead isotope analysis

    Energy Technology Data Exchange (ETDEWEB)

    Finkelstein, Myra E., E-mail: myraf@ucsc.edu [Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, CA 95064 (United States); Kuspa, Zeka E. [Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, CA 95064 (United States); Welch, Alacia [National Park Service, Pinnacles National Park, 5000 Highway 146, Paicines, CA 95043 (United States); Eng, Curtis; Clark, Michael [Los Angeles Zoo and Botanical Gardens, 5333 Zoo Drive, Los Angeles, CA 90027 (United States); Burnett, Joseph [Ventana Wildlife Society, 19045 Portola Dr. Ste. F-1, Salinas, CA 93908 (United States); Smith, Donald R. [Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, CA 95064 (United States)

    2014-10-15

    Lead poisoning is preventing the recovery of the critically endangered California condor (Gymnogyps californianus) and lead isotope analyses have demonstrated that ingestion of spent lead ammunition is the principal source of lead poisoning in condors. Over an 8 month period in 2009, three lead-poisoned condors were independently presented with birdshot embedded in their tissues, evidencing they had been shot. No information connecting these illegal shooting events existed and the timing of the shooting(s) was unknown. Using lead concentration and stable lead isotope analyses of feathers, blood, and recovered birdshot, we observed that: i) lead isotope ratios of embedded shot from all three birds were measurably indistinguishable from each other, suggesting a common source; ii) lead exposure histories re-constructed from feather analysis suggested that the shooting(s) occurred within the same timeframe; and iii) two of the three condors were lead poisoned from a lead source isotopically indistinguishable from the embedded birdshot, implicating ingestion of this type of birdshot as the source of poisoning. One of the condors was subsequently lead poisoned the following year from ingestion of a lead buckshot (blood lead 556 µg/dL), illustrating that ingested shot possess a substantially greater lead poisoning risk compared to embedded shot retained in tissue (blood lead ∼20 µg/dL). To our knowledge, this is the first study to use lead isotopes as a tool to retrospectively link wildlife shooting events. - Highlights: • We conducted a case-based analysis of illegal shootings of California condors. • Blood and feather Pb isotopes were used to reconstruct the illegal shooting events. • Embedded birdshot from the three condors had the same Pb isotope ratios. • Feather and blood Pb isotopes indicated that the condors were shot in a common event. • Ingested shot causes substantially greater lead exposure compared to embedded shot.

  2. Statistical Analysis of the Links between Blocking and Nor'easters

    Science.gov (United States)

    Booth, J. F.; Pfahl, S.

    2015-12-01

    Nor'easters can be loosely defined as extratropical cyclones that develop as they progress northward along the eastern coast of North America. The path makes it possible for these storms to generate storm surge along the coastline and/or heavy precipitation or snow inland. In the present analysis, the path of the storms is investigated relative to the behavior of upstream blocking events over the North Atlantic Ocean. For this analysis, two separate Lagrangian tracking methods are used to identify the extratropical cyclone paths and the blocking events. Using the cyclone paths, Nor'easters are identified and blocking statistics are calculated for the days prior to, during and following the occurrence of the Nor'easters. The path, strength and intensification rates of the cyclones are compared with the strength and location of the blocks. In the event that a Nor'easter occurs, the likelihood of the presence of block at the southeast tip of Greenland is statistically significantly increased, i.e., the presence of a block concurrent with a Nor'easter happens more often than by random coincidence. However no significant link between the strength of the storms and the strength of the block is identified. These results suggest that the presence of the block mainly affects the path of the Nor'easters. On the other hand, in the event of blocking at the southeast tip of Greenland, the likelihood of a Nor'easter, as opposed to a different type of storm is no greater than what one might expect from randomly sampling cyclone tracks. The results confirm a long held understanding in forecast meteorology that upstream blocking is a necessary but not sufficient condition for generating a Nor'easter.

  3. Download - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...t_db_link_en.zip (36.3 KB) - 6 Genome analysis methods pgdbj_dna_marker_linkage_map_genome_analysis_methods_... of This Database Site Policy | Contact Us Download - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  4. Experimental burn plot trial in the Kruger National Park: history, experimental design and suggestions for data analysis

    Directory of Open Access Journals (Sweden)

    R. Biggs

    2003-12-01

    Full Text Available The experimental burn plot (EBP trial initiated in 1954 is one of few ongoing long-termfire ecology research projects in Africa. The trial aims to assess the impacts of differentfire regimes in the Kruger National Park. Recent studies on the EBPs have raised questions as to the experimental design of the trial, and the appropriate model specificationwhen analysing data. Archival documentation reveals that the original design was modified on several occasions, related to changes in the park's fire policy. These modifications include the addition of extra plots, subdivision of plots and changes in treatmentsover time, and have resulted in a design which is only partially randomised. The representativity of the trial plots has been questioned on account of their relatively small size,the concentration of herbivores on especially the frequently burnt plots, and soil variation between plots. It is suggested that these factors be included as covariates inexplanatory models or that certain plots be excluded from data analysis based on resultsof independent studies of these factors. Suggestions are provided for the specificationof the experimental design when analysing data using Analysis of Variance. It is concluded that there is no practical alternative to treating the trial as a fully randomisedcomplete block design.

  5. Establishing a Link Between Prescription Drug Abuse and Illicit Online Pharmacies: Analysis of Twitter Data.

    Science.gov (United States)

    Katsuki, Takeo; Mackey, Tim Ken; Cuomo, Raphael

    2015-12-16

    Youth and adolescent non-medical use of prescription medications (NUPM) has become a national epidemic. However, little is known about the association between promotion of NUPM behavior and access via the popular social media microblogging site, Twitter, which is currently used by a third of all teens. In order to better assess NUPM behavior online, this study conducts surveillance and analysis of Twitter data to characterize the frequency of NUPM-related tweets and also identifies illegal access to drugs of abuse via online pharmacies. Tweets were collected over a 2-week period from April 1-14, 2015, by applying NUPM keyword filters for both generic/chemical and street names associated with drugs of abuse using the Twitter public streaming application programming interface. Tweets were then analyzed for relevance to NUPM and whether they promoted illegal online access to prescription drugs using a protocol of content coding and supervised machine learning. A total of 2,417,662 tweets were collected and analyzed for this study. Tweets filtered for generic drugs names comprised 232,108 tweets, including 22,174 unique associated uniform resource locators (URLs), and 2,185,554 tweets (376,304 unique URLs) filtered for street names. Applying an iterative process of manual content coding and supervised machine learning, 81.72% of the generic and 12.28% of the street NUPM datasets were predicted as having content relevant to NUPM respectively. By examining hyperlinks associated with NUPM relevant content for the generic Twitter dataset, we discovered that 75.72% of the tweets with URLs included a hyperlink to an online marketing affiliate that directly linked to an illicit online pharmacy advertising the sale of Valium without a prescription. This study examined the association between Twitter content, NUPM behavior promotion, and online access to drugs using a broad set of prescription drug keywords. Initial results are concerning, as our study found over 45,000 tweets

  6. Analysis of experimental positron-molecule binding energies

    International Nuclear Information System (INIS)

    Danielson, J R; Surko, C M; Young, J A

    2010-01-01

    Experiments show that positron annihilation on molecules frequently occurs via capture into vibrational Feshbach resonances. In these cases, the downshifts in the annihilation spectra from the vibrational mode spectra provide measures of the positron-molecule binding energies. An analysis of these binding energy data is presented in terms of the molecular dipole polarizability, the permanent dipole moment, and the number of π bonds in aromatic molecules. The results of this analysis are in reasonably good agreement with other information about positron-molecule bound states. Predictions for other targets and promising candidate molecules for further investigation are discussed.

  7. Linear and nonlinear stability analysis, associated to experimental fast reactors

    International Nuclear Information System (INIS)

    Amorim, E.S. do; Moura Neto, C. de; Rosa, M.A.P.

    1980-07-01

    Phenomena associated to the physics of fast neutrons were analysed by linear and nonlinear Kinetics with arbitrary feedback. The theoretical foundations of linear kinetics and transfer functions aiming at the analysis of fast reactors stability, are established. These stability conditions were analitically proposed and investigated by digital and analogic programs. (E.G.) [pt

  8. Procedure for statistical analysis of one-parameter discrepant experimental data

    International Nuclear Information System (INIS)

    Badikov, Sergey A.; Chechev, Valery P.

    2012-01-01

    A new, Mandel–Paule-type procedure for statistical processing of one-parameter discrepant experimental data is described. The procedure enables one to estimate a contribution of unrecognized experimental errors into the total experimental uncertainty as well as to include it in analysis. A definition of discrepant experimental data for an arbitrary number of measurements is introduced as an accompanying result. In the case of negligible unrecognized experimental errors, the procedure simply reduces to the calculation of the weighted average and its internal uncertainty. The procedure was applied to the statistical analysis of half-life experimental data; Mean half-lives for 20 actinides were calculated and results were compared to the ENSDF and DDEP evaluations. On the whole, the calculated half-lives are consistent with the ENSDF and DDEP evaluations. However, the uncertainties calculated in this work essentially exceed the ENSDF and DDEP evaluations for discrepant experimental data. This effect can be explained by adequately taking into account unrecognized experimental errors. - Highlights: ► A new statistical procedure for processing one-parametric discrepant experimental data has been presented. ► Procedure estimates a contribution of unrecognized errors in the total experimental uncertainty. ► Procedure was applied for processing half-life discrepant experimental data. ► Results of the calculations are compared to the ENSDF and DDEP evaluations.

  9. Experimental and numerical analysis of pollutant dispersion from a chimney

    Energy Technology Data Exchange (ETDEWEB)

    Said, N.M.; Mhiri, H. [Ecole Nationale d' Ingenieurs de Monastir, Tunisie (Tunisia). Laboratorie de Mecanique des Fluides et Thermique; Le Palec, G.; Bournot, P. [UNIMECA, Marseille (France). Institut de Mecanique de Marseille, Equipe IMFT

    2005-03-01

    Particle image velocimetry (PIV) is used to extract and characterize the underlying organized motions, i.e. coherent structures, within the near-wake region of a turbulent round jet discharged perpendicularly from a chimney into a crossflow. This flow has been found to be quite complex owing to its three-dimensional nature and the interactions between several flow regions. Analyses of the underlying coherent structures, which play an important role in the physics of the flow, are still rare and mostly based on flow-visualization techniques. Using a PIV technique, we examined the wake regions of the chimney and plume at levels near the top of the chimney. The complex geometry of these structures in the wake of the plume as well as their interaction with the plume as it bends over after emission is discussed. In this paper we describe the Kelvin-Helmholtz vortex structures, the downwash phenomena and the effect of the height of the chimney. Extensive wind tunnel experimental results are presented and compared with numerical simulation. A good level of agreement was found between the results of flow visualization and numerical simulation. (author)

  10. Experimental Dynamic Analysis of a Breathing Cracked Rotor

    Science.gov (United States)

    Guo, Chao-Zhong; Yan, Ji-Hong; Bergman, Lawrence A.

    2017-09-01

    Crack fault diagnostics plays a critical role for rotating machinery in the traditional and Industry 4.0 factory. In this paper, an experiment is set up to study the dynamic response of a rotor with a breathing crack as it passes through its 1/2, 1/3, 1/4 and 1/5 subcritical speeds. A cracked shaft is made by applying fatigue loads through a three-point bending apparatus and then placed in a rotor testbed. The vibration signals of the testbed during the coasting-up process are collected. Whirl orbit evolution at these subcritical speed zones is analyzed. The Fourier spectra obtained by FFT are used to investigate the internal frequencies corresponding to the typical orbit characteristics. The results show that the appearance of the inner loops and orientation change of whirl orbits in the experiment are agreed well with the theoretical results obtained previously. The presence of higher frequencies 2X, 3X, 4X and 5X in Fourier spectra reveals the causes of subharmonic resonances at these subcritical speed zones. The experimental investigation is more systematic and thorough than previously reported in the literature. The unique dynamic behavior of the orbits and frequency spectra are feasible features for practical crack diagnosis. This paper provides a critical technology support for the self-aware health management of rotating machinery in the Industry 4.0 factory.

  11. Experimental analysis of compaction of concrete and mortar

    Science.gov (United States)

    Burlion, Nicolas; Pijaudier-Cabot, Gilles; Dahan, Noël

    2001-12-01

    Compaction of concrete is physically a collapse of the material porous microstructure. It produces plastic strains in the material and, at the same time, an increase of its bulk modulus. This paper presents two experimental techniques aimed at obtaining the hydrostatic response of concrete and mortar. The first one is a uniaxial confined compression test which is quite simple to implement and allows to reach hydrostatic pressures of about 600 MPa. The specimen size is large enough so that concrete with aggregate sizes up to 16 mm can be tested. The second one is a true hydrostatic test performed on smaller (mortar) specimens. Test results show that the hydrostatic response of the material is elasto-plastic with a stiffening effect on both the tangent and unloading bulk moduli. The magnitude of the irreversible volumetric strains depends on the initial porosity of the material. This porosity can be related in a first approximation to the water/cement ratio. A comparison of the hydrostatic responses obtained from the two testing techniques on the same material show that the hydrostatic response of cementitious materials cannot be uncoupled from the deviatoric response, as opposed to the standard assumption in constitutive relations for metal alloys. This feature should be taken into account in the development of constitutive relations for concrete subjected to high confinement pressures which are needed in the modelling of impact problems.

  12. Experimental Analysis on Shrinkage and Swelling in Ordinary Concrete

    Directory of Open Access Journals (Sweden)

    Barbara Kucharczyková

    2017-01-01

    Full Text Available The paper deals with the experimental determination of shrinkage development during concrete ageing. Three concrete mixtures were made. They differed in the amount of cement in the fresh mixture, 300, 350, and 400 kg/m3. In order to determine the influence of plasticiser on the progress of volume changes, another three concrete mixtures were prepared with plasticiser in the amount of 0.25% by cement mass. Measurements were performed with the goal of observing the influence of cement and plasticiser content on the overall development of volume changes in the concrete. Changes in length and mass losses of the concrete during ageing were measured simultaneously. The continuous measurement of concrete mass losses caused by drying of the specimen’s surface proved useful during the interpretation of results obtained from the concrete shrinkage measurement. During the first 24 hours of ageing, all the concrete mixtures exhibited swelling. Its magnitude and progress were influenced by cement, water, and plasticiser content. However, a loss of mass caused by water evaporation from the surface of the specimens was also recorded in this stage. The measured progress of shrinkage corresponded well to the progress of mass loss.

  13. [Experimental analysis of some determinants of inductive reasoning].

    Science.gov (United States)

    Ono, K

    1989-02-01

    Three experiments were conducted from a behavioral perspective to investigate the determinants of inductive reasoning and to compare some methodological differences. The dependent variable used in these experiments was the threshold of confident response (TCR), which was defined as "the minimal sample size required to establish generalization from instances." Experiment 1 examined the effects of population size on inductive reasoning, and the results from 35 college students showed that the TCR varied in proportion to the logarithm of population size. In Experiment 2, 30 subjects showed distinct sensitivity to both prior probability and base-rate. The results from 70 subjects who participated in Experiment 3 showed that the TCR was affected by its consequences (risk condition), and especially, that humans were sensitive to a loss situation. These results demonstrate the sensitivity of humans to statistical variables in inductive reasoning. Furthermore, methodological comparison indicated that the experimentally observed values of TCR were close to, but not as precise as the optimal values predicted by Bayes' model. On the other hand, the subjective TCR estimated by subjects was highly discrepant from the observed TCR. These findings suggest that various aspects of inductive reasoning can be fruitfully investigated not only from subjective estimations such as probability likelihood but also from an objective behavioral perspective.

  14. Stress analysis of blanket vessel for JAERI experimental fusion reactor

    International Nuclear Information System (INIS)

    Sako, K.; Minato, A.

    1979-01-01

    A blanket structure of JAERI Experimental Fusion Reactor (JXFR) consists of about 2,300 blanket cells with round cornered rectangular cross sections (twelve slightly different shapes) and is placed in a vacuum vessel. Each blanket vessel is a double-walled thin-shell structure made of Type 316 stainless steel with a spherical domed surface at the plasma side. Ribs for coolant channel are provided between inner and outer walls. The blanket cell contains Li 2 O pebbles and blocks for tritium breeding and stainless steel blocks for neutron reflection. A coolant is helium gas at 10 kgf/cm 2 (0.98 MPa) and its inlet and outlet temperatures are 300 0 C and 500 0 C. The maxima of heat flux and nuclear heating rate at the first wall are 12 W/cm 2 and 2 W/cc. A design philosophy of the blanket structure is based on high tritium breeding ratio and more effective shielding performance. The thin-shell vessel with a rectangular cross section satisfies the design philosophy. We have designed the blanket structure so that the adjacent vessels are mutually supporting in order to decrease the large deformation and stress due to internal pressure in case of the thin-shell vessel. (orig.)

  15. Study of experimental validation for combustion analysis of GOTHIC code

    International Nuclear Information System (INIS)

    Lee, J. Y.; Yang, S. Y.; Park, K. C.; Jeong, S. H.

    2001-01-01

    In this study, present lumped and subdivided GOTHIC6 code analyses of the premixed hydrogen combustion experiment at the Seoul National University and comparison with the experiment results. The experimental facility has 16367 cc free volume and rectangular shape. And the test was performed with unit equivalence ratio of the hydrogen and air, and with various location of igniter position. Using the lumped and mechanistic combustion model in GOTHIC6 code, the experiments were simulated with the same conditions. In the comparison between experiment and calculated results, the GOTHIC6 prediction of the combustion response does not compare well with the experiment results. In the point of combustion time, the lumped combustion model of GOTHIC6 code does not simulate the physical phenomena of combustion appropriately. In the case of mechanistic combustion model, the combustion time is predicted well, but the induction time of calculation data is longer than the experiment data remarkably. Also, the laminar combustion model of GOTHIC6 has deficiency to simulate combustion phenomena unless control the user defined value appropriately. And the pressure is not a proper variable that characterize the three dimensional effect of combustion

  16. Experimental analysis of shock wave effects in copper

    International Nuclear Information System (INIS)

    Llorca, Fabrice; Buy, Francois; Farre, Jose

    2002-01-01

    This paper proposes the analysis of shock wave effects for a high purity copper. The method developed is based on the analysis of the mechanical behavior of as received and shocked materials. Shock effect is generated through plates impact tests performed in the range 9 GPa to 12 GPa on a single stage light gas gun. Therefore, as-received and impacted materials are characterized on quasi static and Split Hopkinson apparatus. The difference between measured stresses between as received and shocked materials allows to understand shock effects in the low pressure range of study. A specific modeling approach is engaged in order to give indications about the evolution of the microstructure of the materials

  17. Full scale experimental analysis of wind direction changes (EOD)

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose

    2007-01-01

    wind direction gust amplitudes associated with the investigated European sites are low compared to the recommended IEC- values. However, these values, as function of the mean wind speed, are difficult to validate thoroughly due to the limited number of fully correlated measurements....... the magnitudes of a joint gust event defined by a simultaneously wind speed- and direction change in order to obtain an indication of the validity of the magnitudes specified in the IEC code. The analysis relates to pre-specified recurrence periods and is based on full-scale wind field measurements. The wind......A coherent wind speed and wind direction change (ECD) load case is defined in the wind turbine standard. This load case is an essential extreme load case that e.g. may be design driving for flap defection of active stall controlled wind turbines. The present analysis identifies statistically...

  18. Linking Ecological, Environmental and Biogeochemical Data with Multi'omics Analysis

    Science.gov (United States)

    Hasler-Sheetal, H.; Castorani, M. C.; Fragner, L.; Zeng, Y.; Holmer, M.; Glud, R. N.; Weckwerth, W.; Canfield, D. E.

    2016-02-01

    The integrated analysis of multi'omics and environmental data provides a holistic understanding of biological processes and has been proven to be challenging. Here we present our research concept for conducting multi-omics experiments and linking them to environmental data. Hypoxia, reduced light availability and species interaction - all amplified by global warming - cause a global decline of seagrasses. Metabolic mechanisms for coping with these global threats are largely unknown and multi'omics approaches can be an important approach for generating this insight. We applied GC, LC-qTOF-MS and bioinformatics to investigate the effects of environmental pressure on metabolites present in seagrasses. In a first experiment we assessed the metabolomics response of the seagrass Zostera marina towards anoxia and showed that photosynthetically derived oxygen could satisfy the oxygen demand in the leaves. But accumulation of fermentation products in the roots showed that the rhizosphere was under anoxic stress. In contrast nocturnal anoxia caused a biphasic shift in the metabolome of roots and leaves. This nocturnal reprogramming of the metabolome under anoxia indicates a mitigation mechanism to avoid the toxic effects. A pathway enrichment analysis proposes the alanine shunt, the GABA shunt and the 2-oxoglutarate shunt as such mitigation mechanisms that alleviate pyruvate levels and lead to carbon and nitrogen storage during anoxia. In a second experiment, varying light exposure and species interaction of Z. marina with the blue mussel Mytilus edulis - a co-occurring species in seagrass systems - resulted in treatment specific metabolic fingerprints in seagrass. Light modified the metabolic fingerprint expressed in Z. marina to the presence of mussels, indicating varying physiological responses to mussels in normal and low light regimes. Multivariate data-analysis indicated light exposure as main driver (45%) and mussel presence as minor driver (13%) for the metabolic

  19. Theoretical analysis and experimental study of spray degassing method

    International Nuclear Information System (INIS)

    Wu Ruizhi; Shu Da; Sun Baode; Wang Jun; Li Fei; Chen Haiyan; Lu YanLing

    2005-01-01

    A new hydrogen-removal method of aluminum melt, spray degassing, is presented. The thermodynamic and kinetic analysis of the method are discussed. A comparison between the thermodynamics and kinetics of the spray degassing method and rotary impellor degassing method is made. The thermodynamic analysis shows that the relationship between the final hydrogen content of the aluminum melt and the ratio of purge gas flow rate to melt flow rate is linear. The result of thermodynamic calculation shows that, in spray degassing, when the ratio of G/q is larger than 2.2 x 10 -6 , the final hydrogen content will be less than 0.1 ml/100 g Al. From the kinetic analysis, the degassing effect is affected by both the size of melt droplets and the time that melt droplets move from sprayer to the bottom of the treatment tank. In numerical calculation, the hydrogen in aluminum melt can be degassed to 0.05 ml/100 g Al from 0.2 ml/100 g Al in 0.02 s with the spray degassing method. Finally, the water-model experiments are presented with the spray degassing method and rotary impellor degassing method. Melt experiments are also presented. Both the water-model experiments and the melt experiments show that the degassing effect of the spray degassing method is better than that of the rotary impeller method

  20. A Topical Trajectory on Survival: An Analysis of Link-Making in a Sequence of Lessons on Evolution

    Science.gov (United States)

    Rocksén, Miranda; Olander, Clas

    2017-01-01

    This study explores the concept of link-making in relation to communicative strategies applied in the teaching and studying of biological evolution. The analysis focused on video recordings of 11 lessons on biological evolution conducted in a Swedish 9th grade class of students aged 15 years. It reveals how the teacher and students connected…

  1. Theoretical analysis of experimental results on SG-1 FEL

    International Nuclear Information System (INIS)

    Yang Zhenhua; Wu Shangqing; Tian Shihong; Dong Zhiwei; Wu Yupu

    1994-01-01

    In order to study the SG-1 FEL and the beam transport thoroughly, and draw certain quantitative conclusions, we developed 3-D WAGFEL code to describe the FEL evolution and 3-D CEBQ code to describe the beam transport. The CEBQ code can simulate the 3-D transport of the electron beam in the modulation section with linear approximation of space charge. According to the first ASE experiments results, the LIA provided a 2 kA, 3.0 MeV beam with a normalized emittance of 0.6 πrad·cm, an energy spread (FWHM) of 4%, resulting in a beam brightness nearly 10 8 A/(πm·rad) 2 . The numerical simulation showed that the quality of the beam was good enough to abandon the 9-m long beam line and substitute it with a 2-m long drifting and focusing region. The second series of ASE and amplifier experiments began in October 1992. The beam transport section was modified. The ASE output power, the amplifier output power and detuning curve was measured. We analysed the experimental results using the WAGFEL and CEBQ codes with parameters equal to those of experiments. Firstly we followed 4096 electrons to simulate the transport process of the beam in the beam line under the condition of I = 2 kA, r b = 1 cm, γ = 6.8, Δγ/γ 4%, ε rms = 0.6 (πrad·cm). Through the simulation, we predicted that the beam current injected into the wiggler was about 611 A. Based on these beam parameters at the entrance of the wiggler, we simulated the FEL process with P in = 300 W. The results are also in Fig.7,8,9

  2. Nuclear analysis of the experimental VHTR fuel lattice

    International Nuclear Information System (INIS)

    Doi, Takeshi; Shindo, Ryuiti; Hirano, Mitsumasa; Takano, Makoto

    1984-11-01

    Nuclear properties of a fuel lattice in the experimental VHTR core were analyzed with DELIGHT-6 and SRAC codes. Analytical results by both codes were compared by using various calculational model. The nuclear parameters were analyzed, such as a multiplication factor of a fuel lattice and it's variation with burnup, a temperature effect on reactivity, an effect of double-heterogeniety in a resonance absorption calculation, a resonance integral of 238 U and a reactivity worth of burnable poison. From these analyses, following results were obtained. Firstly, on calculational models, 1) Effect of double-heterogeniety in the resonance absorption calculation for Mark-III fuel element, causing a decrease of about 5.5 barns in the resonance integral and an increase of about 2.6 %ΔK in the infinite multiplication factor, 2) The heterogeneous calculation with the collision probability method resulted in about 0.6 %ΔK higher the multiplication factor of fuel lattice than that with the point model, 3) The reactivity worth of burnable poison rod by a multi-region model is about 20 % less than that by a 2-region model at an initial state of burnup and it's variation with burnup are fairly different, Secondly, on comparison between the results by DELIGHT-6 and SRAC, 4) The nuclear parameters obtained with both codes agreed well, Lastly, on the improvement in DELIGHT-6, 5) Consideration of the neutron spectrum shielding effect in the resonance effective cross section calculation caused a decrease of about 2.4 %ΔK in the multiplication factor of fuel lattice, 6) The lattice multiplication factor increased about 0.5 %ΔK by introducing lambda-parameters for the non-resonant nuclie. (J.P.N.)

  3. Link Analysis of High Throughput Spacecraft Communication Systems for Future Science Missions

    Science.gov (United States)

    Simons, Rainee N.

    2015-01-01

    NASA's plan to launch several spacecrafts into low Earth Orbit (LEO) to support science missions in the next ten years and beyond requires down link throughput on the order of several terabits per day. The ability to handle such a large volume of data far exceeds the capabilities of current systems. This paper proposes two solutions, first, a high data rate link between the LEO spacecraft and ground via relay satellites in geostationary orbit (GEO). Second, a high data rate direct to ground link from LEO. Next, the paper presents results from computer simulations carried out for both types of links taking into consideration spacecraft transmitter frequency, EIRP, and waveform; elevation angle dependent path loss through Earths atmosphere, and ground station receiver GT.

  4. Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes.

    Directory of Open Access Journals (Sweden)

    Peter Hevezi

    Full Text Available Efforts to unravel the mechanisms underlying taste sensation (gustation have largely focused on rodents. Here we present the first comprehensive characterization of gene expression in primate taste buds. Our findings reveal unique new insights into the biology of taste buds. We generated a taste bud gene expression database using laser capture microdissection (LCM procured fungiform (FG and circumvallate (CV taste buds from primates. We also used LCM to collect the top and bottom portions of CV taste buds. Affymetrix genome wide arrays were used to analyze gene expression in all samples. Known taste receptors are preferentially expressed in the top portion of taste buds. Genes associated with the cell cycle and stem cells are preferentially expressed in the bottom portion of taste buds, suggesting that precursor cells are located there. Several chemokines including CXCL14 and CXCL8 are among the highest expressed genes in taste buds, indicating that immune system related processes are active in taste buds. Several genes expressed specifically in endocrine glands including growth hormone releasing hormone and its receptor are also strongly expressed in taste buds, suggesting a link between metabolism and taste. Cell type-specific expression of transcription factors and signaling molecules involved in cell fate, including KIT, reveals the taste bud as an active site of cell regeneration, differentiation, and development. IKBKAP, a gene mutated in familial dysautonomia, a disease that results in loss of taste buds, is expressed in taste cells that communicate with afferent nerve fibers via synaptic transmission. This database highlights the power of LCM coupled with transcriptional profiling to dissect the molecular composition of normal tissues, represents the most comprehensive molecular analysis of primate taste buds to date, and provides a foundation for further studies in diverse aspects of taste biology.

  5. Frames as visual links between paintings and the museum environment: An analysis of statistical image properties

    Directory of Open Access Journals (Sweden)

    Christoph eRedies

    2013-11-01

    Full Text Available Frames provide a visual link between artworks and their surround. We asked how image properties change as an observer zooms out from viewing a painting alone, to viewing the painting with its frame and, finally, the framed painting in its museum environment (museum scene. To address this question, we determined three higher-order image properties that are based on histograms of oriented luminance gradients. First, complexity was measured as the sum of the strengths of all gradients in the image. Second, we determined the self-similarity of histograms of the orientated gradients at different levels of spatial analysis. Third, we analyzed how much gradient strength varied across orientations (anisotropy. Results were obtained for three art museums that exhibited paintings from three major periods of Western art. In all three museums, the mean complexity of the frames was higher than that of the paintings or the museum scenes. Frames thus provide a barrier of complexity between the paintings and their exterior. By contrast, self-similarity and anisotropy values of images of framed paintings were intermediate between the images of the paintings and the museum scenes, i.e., the frames provided a transition between the paintings and their surround. We also observed differences between the three museums that may reflect modified frame usage in different art periods. For example, frames in the museum for 20th century art tended to be smaller and less complex than in the two other two museums that exhibit paintings from earlier art periods (13th-18th century and 19th century, respectively. Finally, we found that the three properties did not depend on the type of reproduction of the paintings (photographs in museums, scans from books or images from the Google Art Project. To the best of our knowledge, this study is the first to investigate the relation between frames and paintings by measuring physically defined, higher-order image properties.

  6. Using harmonical analysis for experimental verification of reactor dynamics

    International Nuclear Information System (INIS)

    Hrstka, V.

    1974-01-01

    The questions are discussed of the accuracy of the method of static programming when applied to digital harmonic analysis, with regard to the variation of the mean value of the analyzed signals, and to the use of symmetrical trapezoidal periodical signals. The evaluation is made of the suitability of the above-mentioned method in determining the frequency characteristic of the SR-OA reactor. The results obtained were applied to planning the start-up experiments of the KS-150 reactor at the A-1 nuclear power station. (author)

  7. Impact parameter determination in experimental analysis using neural network

    International Nuclear Information System (INIS)

    Haddad, F.; David, C.; Freslier, M.; Aichelin, J.; Haddad, F.; Hagel, K.; Li, J.; Mdeiwayeh, N.; Natowitz, J.B.; Wada, R.; Xiao, B.

    1997-01-01

    A neural network is used to determine the impact parameter in 40 Ca + 40 Ca reactions. The effect of the detection efficiency as well as the model dependence of the training procedure have been studied carefully. An overall improvement of the impact parameter determination of 25 % is obtained using this technique. The analysis of Amphora 40 Ca+ 40 Ca data at 35 MeV per nucleon using a neural network shows two well separated classes of events among the selected 'complete' events. (authors)

  8. Analysis of the harmonic and intermodulation distortion in a multimode fiber optic link.

    Science.gov (United States)

    Gasulla, I; Capmany, J

    2007-07-23

    We present an analytical evaluation of the harmonic and the intermodulation distortion effects produced in the transmission of an analog signal composed of various RF tones through a multimode fiber link. It is based on the electric field propagation model previously published by the authors. Results show the possibility of implementing subcarrier multiplexing techniques (SCM) with Composite Second Order (CSO) values below -50 dBc over short and middle reach multimode fiber links.

  9. Uncertainty Analysis of RBMK-Related Experimental Data

    International Nuclear Information System (INIS)

    Urbonas, Rolandas; Kaliatka, Algirdas; Liaukonis, Mindaugas

    2002-01-01

    An attempt to validate state-of-the-art thermal hydraulic code ATHLET (GRS, Germany) on the basis of E-108 test facility was made. Originally this code was developed and validated for different type reactors than RBMK. Since state-of-art thermal hydraulic codes are widely used for simulation of RBMK reactors, further codes' implementation and validation is required. The phenomena associated with channel type flow instabilities and CHF were found to be an important step in the frame of the overall effort of state-of-the-art validation and application for RBMK reactors. In the paper one-channel approach analysis is presented. Thus, the oscillatory behaviour of the system was not detected. The results show dependence on the nodalization used in the heated channels, initial and boundary conditions and code selected models. It is shown that the code is able to predict a sudden heat structure temperature excursion, when critical heat flux is approached. GRS developed uncertainty and sensitivity methodology was employed in the analysis. (authors)

  10. Experimental and Numerical analysis of Metallic Bellow for Acoustic Performance

    Science.gov (United States)

    Panchwadkar, Amit A.; Awasare, Pradeep J., Dr.; Ingle, Ravidra B., Dr.

    2017-08-01

    Noise will concern about the work environment of industry. Machinery environment has overall noise which interrupts communication between the workers. This problem of miscommunication and health hazard will make sense to go for noise attenuation. Modification in machine setup may affect the performance of it. Instead of that, Helmholtz resonator principle will be a better option for noise reduction along the transmission path. Resonator has design variables which gives resonating frequency will help us to confirm the frequency range. This paper deals with metallic bellow which behaves like inertial mass under incident sound wave. Sound wave energy is affected by hard boundary condition of resonator and bellow. Metallic bellow is used in combination with resonator to find out Transmission loss (TL). Microphone attachment with FFT analyzer will give the frequency range for numerical analysis. Numerical analysis of bellow and resonator is carried out to summarize the acoustic behavior of bellow. Bellow can be numerically analyzed to check noise attenuation for centrifugal blower. An impedance tube measurement technique is performed to validate the numerical results for assembly. Dimensional and shape modification can be done to get the acoustic performance of bellow.

  11. Molecular analysis of radiation-induced experimental tumors in mice

    International Nuclear Information System (INIS)

    Niwa, O.; Muto, M.; Suzuki, F.

    1992-01-01

    Molecular analysis was made on mouse tumors induced by radiation and chemicals. Expression of oncogenes was studied in 12 types of 178 mouse tumors. Southern blotting was done on tumors in which overexpression of oncogenes was noted. Amplification of the myc oncogene was found in chemically induced sarcomas, but not those induced by radiations. Radiogenic thymomas were studied in detail. These thymomas were induced in two different ways. The first was thymomas induced by direct irradiation of F1 mice between C57BL/6NxC3H/He. Southern analysis of DNA revealed deletion of specific minisatellite bands in these tumors. DNA from directly induced thymomas induced focus formation when transfected into normal Golden hamster cells. The mouse K-ras oncogene was detected in these transformants. The second type of thymomas was induced by X-irradiation of thymectomized B10.thy1.2 mice in which normal thymus from congenic B10,thy1.1. mice was grafted. Thymomas of the donor origin was analysed by transfection and the transformants by DNA from those indirectly induced thymomas did not contain activated ras oncogenes. (author)

  12. Bit-error-rate performance analysis of self-heterodyne detected radio-over-fiber links using phase and intensity modulation

    DEFF Research Database (Denmark)

    Yin, Xiaoli; Yu, Xianbin; Tafur Monroy, Idelfonso

    2010-01-01

    We theoretically and experimentally investigate the performance of two self-heterodyne detected radio-over-fiber (RoF) links employing phase modulation (PM) and quadrature biased intensity modulation (IM), in term of bit-error-rate (BER) and optical signal-to-noise-ratio (OSNR). In both links, self...

  13. Centre of Gravity (C.O.G)-Based Analysis on the Dynamics of the Extendable Double-Link Two-Wheeled Mobile Robot

    International Nuclear Information System (INIS)

    Rahman, M T Abdul; Ahmad, S; Akmeliawati, R; Altalmas, T; Aula, A

    2013-01-01

    This paper discusses about the analysis on the centre of gravity (C.O.G) in affecting the input reference of the motion control of the extendable double-link of two-wheeled mobile robot. The proposed system mimics double inverted pendulum, where the angular position of the first link (Link1) is to be varied depends on the value of the angular position of the second link (Link2) and the elongation of the extendable-link (Link3) that is attached to Link2 with different payload. The two-wheeled mobile robot together with the extendable link on Link2 makes that system become more flexible but yet, the system has become more unstable. The inclination of extendable link at any interest angle will affect the C.O.G of the system especially when the payload is having a significant weight. This two-wheeled mobile robot can be balanced on the condition that the system's center of gravity must be located on the centre of the wheels. Therefore the input reference of Link1 will be determined from the C.O.G analysis of the system with the payload. Preliminary results show that the angular position of Link1 can be set at suitable degree based on C.O.G analysis that is used for motion control

  14. Exoproteome analysis reveals higher abundance of proteins linked to alkaline stress in persistent Listeria monocytogenes strains.

    Science.gov (United States)

    Rychli, Kathrin; Grunert, Tom; Ciolacu, Luminita; Zaiser, Andreas; Razzazi-Fazeli, Ebrahim; Schmitz-Esser, Stephan; Ehling-Schulz, Monika; Wagner, Martin

    2016-02-02

    The foodborne pathogen Listeria monocytogenes, responsible for listeriosis a rare but severe infection disease, can survive in the food processing environment for month or even years. So-called persistent L. monocytogenes strains greatly increase the risk of (re)contamination of food products, and are therefore a great challenge for food safety. However, our understanding of the mechanism underlying persistence is still fragmented. In this study we compared the exoproteome of three persistent strains with the reference strain EGDe under mild stress conditions using 2D differential gel electrophoresis. Principal component analysis including all differentially abundant protein spots showed that the exoproteome of strain EGDe (sequence type (ST) 35) is distinct from that of the persistent strain R479a (ST8) and the two closely related ST121 strains 4423 and 6179. Phylogenetic analyses based on multilocus ST genes showed similar grouping of the strains. Comparing the exoproteome of strain EGDe and the three persistent strains resulted in identification of 22 differentially expressed protein spots corresponding to 16 proteins. Six proteins were significantly increased in the persistent L. monocytogenes exoproteomes, among them proteins involved in alkaline stress response (e.g. the membrane anchored lipoprotein Lmo2637 and the NADPH dehydrogenase NamA). In parallel the persistent strains showed increased survival under alkaline stress, which is often provided during cleaning and disinfection in the food processing environments. In addition, gene expression of the proteins linked to stress response (Lmo2637, NamA, Fhs and QoxA) was higher in the persistent strain not only at 37 °C but also at 10 °C. Invasion efficiency of EGDe was higher in intestinal epithelial Caco2 and macrophage-like THP1 cells compared to the persistent strains. Concurrently we found higher expression of proteins involved in virulence in EGDe e.g. the actin-assembly-inducing protein ActA and the

  15. Experimental impact testing and analysis of composite fan cases

    Science.gov (United States)

    Vander Klok, Andrew Joe

    For aircraft engine certification, one of the requirements is to demonstrate the ability of the engine to withstand a fan blade-out (FBO) event. A FBO event may be caused by fatigue failure of the fan blade itself or by impact damage of foreign objects such as bird strike. An un-contained blade can damage flight critical engine components or even the fuselage. The design of a containment structure is related to numerous parameters such as the blade tip speed; blade material, size and shape; hub/tip diameter; fan case material, configuration, rigidity, etc. To investigate all parameters by spin experiments with a full size rotor assembly can be prohibitively expensive. Gas gun experiments can generate useful data for the design of engine containment cases at much lower costs. To replicate the damage modes similar to that on a fan case in FBO testing, the gas gun experiment has to be carefully designed. To investigate the experimental procedure and data acquisition techniques for FBO test, a low cost, small spin rig was first constructed. FBO tests were carried out with the small rig. The observed blade-to-fan case interactions were similar to those reported using larger spin rigs. The small rig has the potential in a variety of applications from investigating FBO events, verifying concept designs of rotors, to developing spin testing techniques. This rig was used in the developments of the notched blade releasing mechanism, a wire trigger method for synchronized data acquisition, high speed video imaging and etc. A relationship between the notch depth and the release speed was developed and verified. Next, an original custom designed spin testing facility was constructed. Driven by a 40HP, 40,000rpm air turbine, the spin rig is housed in a vacuum chamber of phi72inx40in (1829mmx1016mm). The heavily armored chamber is furnished with 9 viewports. This facility enables unprecedented investigations of FBO events. In parallel, a 15.4ft (4.7m) long phi4.1inch (105mm

  16. 10 GHz microstrip spanar antennas: an experimental analysis

    International Nuclear Information System (INIS)

    Othman, Mohd Azlishah; Azman, Hazwani; Husain, Mohd Nor; Aziz, Mohamad Zoinol Abidin Abd; Rahim, Yahaya Abd; Pee, Ahmad Nairn Che; Motsidi, Mohamad Radzi; Othman, Mohd Fairuz Iskandar

    2014-01-01

    This paper presents Spanar Antenna designed using CST Microwave Studio Simulation 2011. The proposed antenna was designed to operate at 10 GHz, which suggested return loss, S 11 must be less than -10 dB and voltage standing wave ratio (VSWR) must be less than 2. The best performance of simulation of Spanar Antenna was obtained at a small size of 24.8 mm × 8.0 mm with dimension board of FR4 substrate 31.7 mm × 18.5 mm. The thickness (h) and dielectric constant (εr) of substrate were 1.6 mm and 4.7. An analysis between simulation result and measurement result has been compared in order to see the antenna performance.

  17. Wireless sensor networks concepts, applications, experimentation and analysis

    CERN Document Server

    Fahmy, Hossam Mahmoud Ahmad

    2016-01-01

    This book focuses on the principles of wireless sensor networks (WSNs), their applications, and their analysis tools, with meticulous attention paid to definitions and terminology. This book presents the adopted technologies and their manufacturers in detail, making WSNs tangible for the reader. In introductory computer networking books, chapter sequencing follows the bottom-up or top-down architecture of the 7-layer protocol. This book addresses subsequent steps in this process, both horizontally and vertically, thus fostering a clearer and deeper understanding through chapters that elaborate on WSN concepts and issues. With such depth, this book is intended for a wide audience; it is meant to be a helper and motivator for senior undergraduates, postgraduates, researchers, and practitioners. It lays out important concepts and WSN-relate applications; uses appropriate literature to back research and practical issues; and focuses on new trends. Senior undergraduate students can use it to familiarize themselves...

  18. STATISTICS, Program System for Statistical Analysis of Experimental Data

    International Nuclear Information System (INIS)

    Helmreich, F.

    1991-01-01

    1 - Description of problem or function: The package is composed of 83 routines, the most important of which are the following: BINDTR: Binomial distribution; HYPDTR: Hypergeometric distribution; POIDTR: Poisson distribution; GAMDTR: Gamma distribution; BETADTR: Beta-1 and Beta-2 distributions; NORDTR: Normal distribution; CHIDTR: Chi-square distribution; STUDTR : Distribution of 'Student's T'; FISDTR: Distribution of F; EXPDTR: Exponential distribution; WEIDTR: Weibull distribution; FRAKTIL: Calculation of the fractiles of the normal, chi-square, Student's, and F distributions; VARVGL: Test for equality of variance for several sample observations; ANPAST: Kolmogorov-Smirnov test and chi-square test of goodness of fit; MULIRE: Multiple linear regression analysis for a dependent variable and a set of independent variables; STPRG: Performs a stepwise multiple linear regression analysis for a dependent variable and a set of independent variables. At each step, the variable entered into the regression equation is the one which has the greatest amount of variance between it and the dependent variable. Any independent variable can be forced into or deleted from the regression equation, irrespective of its contribution to the equation. LTEST: Tests the hypotheses of linearity of the data. SPRANK: Calculates the Spearman rank correlation coefficient. 2 - Method of solution: VARVGL: The Bartlett's Test, the Cochran's Test and the Hartley's Test are performed in the program. MULIRE: The Gauss-Jordan method is used in the solution of the normal equations. STPRG: The abbreviated Doolittle method is used to (1) determine variables to enter into the regression, and (2) complete regression coefficient calculation. 3 - Restrictions on the complexity of the problem: VARVGL: The Hartley's Test is only performed if the sample observations are all of the same size

  19. Database Description - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ... QTL list, Plant DB link & Genome analysis methods Alternative name - DOI 10.18908/lsdba.nbdc01194-01-000 Cr...ers and QTLs are curated manually from the published literature. The marker information includes marker sequences, genotyping methods... Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  20. Influence of microstructure on the thermal creep behaviour of zirconium alloys: experimental analysis and implementation of homogenization approaches

    International Nuclear Information System (INIS)

    Brenner, R.

    2001-01-01

    Zirconium alloys widely used in the nuclear industry can present thermomechanical variability of their behavior (especially for thermal creep) as a function of their microstructure. To have a better control of the mechanical behavior of these alloys and also to take into account the possible evolution of their fabrication process (chemical composition, thermal treatments,... ), it is important to have a modeling tool which help us to describe the relationship between the microstructure and the macroscopic behavior. This study contributes to establish a predictive modelling, based on an experimental analysis coupled with a homogenization approach of the thermal creep behavior of Zr alloys. The experimental analysis of the crystallographic texture effect for Zircaloy-4 alloys shows how the strain rate and stress exponent of the different glide systems are anisotropic. Transmission Electronic Microscopy analysis have been undertaken in order to determine the link between the texture and the activated slip system considering various mechanical tests (Ioading paths). The experimental analysis for Zr-Nb-1%-O bring to evidence the solid solution effect of Nb on the hardening of this alloy and the weak effect of the precipitates distribution on thermal creep behavior. An elasto-viscoplastic micromechanical modelling has been developed taking into account the microstructure effects on the macroscopic behavior of Zr alloys. The 'quasi-elastic' approximate of the self consistent scheme based on the affine formulation is proposed and compared with others and earlier formulations. The accuracy of this formulation for our study is demonstrated, as well as the from the scale transition point of view and the simple numerical resolution. A good agreement is found for the description of thermal creep behavior of Zircaloy-4 and Zr-Nb-1%-O alloys. The analysis of the results at a local scale (especially slip system secondary activities) gives the current limit for the description of

  1. Analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices.

    Science.gov (United States)

    Perera, Handunge Kumudu Irani; Handuwalage, Charith Sandaruwan

    2015-06-09

    Protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. Glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method. Methanol extracts of thirteen plants including nine antidiabetic plants and three spices were used. Lysozyme and fructose were incubated at 37 °C in the presence or absence of different concentrations of plant extracts up to 31 days. Standard glycation inhibitor aminoguanidine and other appropriate controls were included. A recently established sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE) method was used to detect the products of protein cross-linking in the incubation mixtures. High molecular weight protein products representing the dimer, trimer and tetramer of lysozyme were detected in the presence of fructose. Among the nine antidiabetic plants, seven showed glycation induced protein cross-linking inhibitory effects namely Ficus racemosa (FR) stem bark, Gymnema sylvestre (GS) leaves, Musa paradisiaca (MP) yam, Phyllanthus debilis (PD) whole plant, Phyllanthus emblica (PE) fruit, Pterocarpus marsupium (PM) latex and Tinospora cordifolia (TC) leaves. Inhibition observed with Coccinia grandis (CG) leaves and Strychnos potatorum (SP) seeds were much low. Leaves of Gymnema lactiferum (GL), the plant without known antidiabetic effects showed the lowest inhibition. All three spices namely Coriandrum sativum (CS) seeds, Cinnamomum zeylanicum (CZ) bark and Syzygium aromaticum (SA) flower buds showed cross-link inhibitory effects with higher effects in CS and SA. PD, PE, PM, CS and SA showed almost complete inhibition on the formation of cross-linking with 25 μg/ml extracts. Methanol extracts of PD, PE, PM, CS and SA have shown promising inhibitory effects on glycation induced protein cross-linking.

  2. Communication and cooperation in networked environments: an experimental analysis.

    Science.gov (United States)

    Galimberti, C; Ignazi, S; Vercesi, P; Riva, G

    2001-02-01

    Interpersonal communication and cooperation do not happen exclusively face to face. In work contexts, as in private life, there are more and more situations of mediated communication and cooperation in which new online tools are used. However, understanding how to use the Internet to support collaborative interaction presents a substantial challenge for the designers and users of this emerging technology. First, collaborative Internet environments are designed to serve a purpose, so must be designed with intended users' tasks and goals explicitly considered. Second, in cooperative activities the key content of communication is the interpretation of the situations in which actors are involved. So, the most effective way of clarifying the meaning of messages is to connect them to a shared context of meaning. However, this is more difficult in the Internet than in other computer-based activities. This paper tries to understand the characteristics of cooperative activities in networked environments--shared 3D virtual worlds--through two different studies. The first used the analysis of conversations to explore the characteristics of the interaction during the cooperative task; the second analyzed whether and how the level of immersion in the networked environments influenced the performance and the interactional process. The results are analyzed to identify the psychosocial roots used to support cooperation in a digital interactive communication.

  3. Edge dislocations in dicalcium silicates: Experimental observations and atomistic analysis

    International Nuclear Information System (INIS)

    Shahsavari, Rouzbeh; Chen, Lu; Tao, Lei

    2016-01-01

    Understanding defects and influence of dislocations on dicalcium silicates (Ca 2 SiO 4 ) is a challenge in cement science. We report a high-resolution transmission electron microscopy image of edge dislocations in Ca 2 SiO 4 , followed by developing a deep atomic understanding of the edge dislocation-mediated properties of five Ca 2 SiO 4 polymorphs. By decoding the interplay between core dislocation energies, core structures, and nucleation rate of reactivity, we find that γ-C2S and α-C2S polymorphs are the most favorable polymorphs for dislocations in Ca 2 SiO 4 , mainly due to their large pore channels which take away majority of the distortions imposed by edge dislocations. Furthermore, in the context of edge dislocation, while α-C2S represents the most active polymorph for reactivity and crystal growth, β-C2S represents the most brittle polymorph suitable for grinding. This work is the first report on the atomistic-scale analysis of edge dislocation-mediated properties of Ca 2 SiO 4 and may open up new opportunities for tuning fracture and reactivity processes of Ca 2 SiO 4 and other cement components.

  4. A Contrastive Analysis of the Links of Textuality in Abstracts Written by Persian and English Writers in Clinical Psychology Journals

    Directory of Open Access Journals (Sweden)

    Abbas Mehrabi Boshrabadi

    2014-07-01

    Full Text Available It is generally agreed today that lexical cohesion is one of the fundamental elements of the text texture achieved through lexical semantic relations dominating the arrangement of propositional units in a text. Accordingly, this study sought to compare and contrast the textual links or lexical cohesive devices enlisted in the psychological abstracts written by Persian and English writers. To this end, 40 abstracts from Persian and English articles, 20 in each language, published in clinical psychology journals were randomly selected. The framework serving as tertium comprationis for analyzing lexical cohesion markers was derived from Halliday and Hasan’s (1976 model [Halliday, M. A. K., & Hasan, R. (1976. Cohesion in English. London: Longman]. A frequency count analysis was employed to gauge the number of occurrences of cohesive links in the selected corpus. The results revealed that lexical links of synonymy and repetition were more frequent than other cohesive devices in both English and Persian abstracts.

  5. Analysis of a Combined Antenna Arrays and Reverse-Link Synchronous DS-CDMA System over Multipath Rician Fading Channels

    Directory of Open Access Journals (Sweden)

    Kim Yong-Seok

    2005-01-01

    Full Text Available We present the BER analysis of antenna array (AA receiver in reverse-link asynchronous multipath Rician channels and analyze the performance of an improved AA system which applies a reverse-link synchronous transmission technique (RLSTT in order to effectively make a better estimation of covariance matrices at a beamformer-RAKE receiver. In this work, we provide a comprehensive analysis of user capacity which reflects several important factors such as the ratio of the specular component power to the Rayleigh fading power, the shape of multipath intensity profile, and the number of antennas. Theoretical analysis demonstrates that for the case of a strong specular path's power or for a high decay factor, the employment of RLSTT along with AA has the potential of improving the achievable capacity by an order of magnitude.

  6. One and a half million medical papers reveal a link between author gender and attention to gender and sex analysis

    DEFF Research Database (Denmark)

    Nielsen, Mathias Wullum; Andersen, Jens Peter; Schiebinger, Londa

    2017-01-01

    Gender and sex analysis is increasingly recognized as a key factor in creating better medical research and health care. Using a sample of more than 1.5 million medical research papers, our study examined the potential link between women’s participation in medical science and attention to gender......-related and sex-related factors in disease-specific research. Adjusting for variations across countries, disease topics and medical research areas, we compared the participation of women authors in studies that do and do not involve gender and sex analysis. Overall, our results show a robust positive correlation...... between women’s authorship and the likelihood of a study including gender and sex analysis. These findings corroborate discussions of how women’s participation in medical science links to research outcomes, and show the mutual benefits of promoting both the scientific advancement of women...

  7. Construction and analysis of experimental DNA vaccines against megalocytivirus.

    Science.gov (United States)

    Zhang, Min; Hu, Yong-Hua; Xiao, Zhi-Zhong; Sun, Yun; Sun, Li

    2012-11-01

    Iridoviruses are large double-stranded DNA viruses with icosahedral capsid. The Iridoviridae family contains five genera, one of which is Megalocytivirus. Megalocytivirus has emerged in recent years as an important pathogen to a wide range of marine and freshwater fish. In this study, we aimed at developing effective genetic vaccines against megalocytivirus affecting farmed fish in China. For this purpose, we constructed seven DNA vaccines based on seven genes of rock bream iridovirus isolate 1 from China (RBIV-C1), a megalocytivirus with a host range that includes Japanese flounder (Paralichthys olivaceus) and turbot (Scophthalmus maximus). The protective potentials of these vaccines were examined in a turbot model. The results showed that after vaccination via intramuscular injection, the vaccine plasmids were distributed in spleen, kidney, muscle, and liver, and transcription of the vaccine genes and production of the vaccine proteins were detected in these tissues. Following challenge with a lethal-dose of RBIV-C1, fish vaccinated with four of the seven DNA vaccines exhibited significantly higher levels of survival compared to control fish. Of these four protective DNA vaccines, pCN86, which is a plasmid that expresses an 86-residue viral protein, induced the highest protection. Immunological analysis showed that pCN86 was able to (i) stimulate the respiratory burst of head kidney macrophages at 14 d, 21 d, and 28 d post-vaccination, (ii) upregulate the expression of immune relevant genes involved in innate and adaptive immunity, and (iii) induce production of serum antibodies that, when incubated with RBIV-C1 before infection, significantly reduced viral loads in kidney and spleen following viral infection of turbot. Taken together, these results indicate that pCN86 is an effective DNA vaccine that may be used in the control of megalocytivirus-associated diseases in aquaculture. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Integrated Experimental and Model-based Analysis Reveals the Spatial Aspects of EGFR Activation Dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Shankaran, Harish; Zhang, Yi; Chrisler, William B.; Ewald, Jonathan A.; Wiley, H. S.; Resat, Haluk

    2012-10-02

    The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases, and controls a diverse set of cellular responses relevant to development and tumorigenesis. ErbB activation is a complex process involving receptor-ligand binding, receptor dimerization, phosphorylation, and trafficking (internalization, recycling and degradation), which together dictate the spatio-temporal distribution of active receptors within the cell. The ability to predict this distribution, and elucidation of the factors regulating it, would help to establish a mechanistic link between ErbB expression levels and the cellular response. Towards this end, we constructed mathematical models for deconvolving the contributions of receptor dimerization and phosphorylation to EGFR activation, and to examine the dependence of these processes on sub-cellular location. We collected experimental datasets for EGFR activation dynamics in human mammary epithelial cells, with the specific goal of model parameterization, and used the data to estimate parameters for several alternate models. Model-based analysis indicated that: 1) signal termination via receptor dephosphorylation in late endosomes, prior to degradation, is an important component of the response, 2) less than 40% of the receptors in the cell are phosphorylated at any given time, even at saturating ligand doses, and 3) receptor dephosphorylation rates at the cell surface and early endosomes are comparable. We validated the last finding by measuring EGFR dephosphorylation rates at various times following ligand addition both in whole cells, and in endosomes using ELISAs and fluorescent imaging. Overall, our results provide important information on how EGFR phosphorylation levels are regulated within cells. Further, the mathematical model described here can be extended to determine receptor dimer abundances in cells co-expressing various levels of ErbB receptors. This study demonstrates that an iterative cycle of

  9. Corrosion analysis in mooring chain links; Analise de corrosao em elos de amarras

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Silvia N.; Pereira, Marcos V. [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil). Dept. de Ciencia dos Materiais e Metalurgia; Costa, Luis C. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil). Centro de Pesquisas; Motta, Sergio H. [Brasilamarras - Companhia Brasileira de Amarras, Niteroi, RJ (Brazil)

    2004-07-01

    The purpose of this work was to characterize the localized corrosion phenomenon in the weld region of offshore mooring chain links type ORQ. In this sense, a number of chain links were selected after finishing their projected life time without corrosion signs (chains without corrosion) as well as chain links which showed a reduced life time caused by localized corrosion (chains with corrosion). In the sequence, electrochemistry tests evaluated the corrosion susceptibility of the different regions of the weld joint. The results showed that the heat affected zone concerning the chains with corrosion was the anodic region, with high corrosion rate, while the same region on the not corroded chains was the cathodic one, with low corrosion rate. (author)

  10. Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis

    Directory of Open Access Journals (Sweden)

    Hongmei Chen

    2009-01-01

    Full Text Available We have previously reported the preparation of the genipin cross-linked alginate-chitosan (GCAC microcapsules composed of an alginate core with a genipin cross-linked chitosan membrane. This paper is the further investigation on their structural and physical characteristics. Results showed that the GCAC microcapsules had a smooth and dense surface and a networked interior. Cross-linking by genipin substantially reduced swelling and physical disintegration of microcapsules induced by nongelling ions and calcium sequestrants. Strong resistance to mechanical shear forces and enzymatic degradation was observed. Furthermore, the GCAC membranes were permeable to bovine serum albumin and maintained a molecular weight cutoff at 70 KD, analogous to the widely studied alginate-chitosan, and alginate-poly-L-lysine-alginate microcapsules. The release features and the tolerance of the GCAC microcapsules in the stimulated gastrointestinal environment were also investigated. This GCAC microcapsule formulation offers significant potential as a delivery vehicle for many biomedical applications.

  11. Analysis of fog effects on terrestrial Free Space optical communication links

    KAUST Repository

    Esmail, Maged Abdullah

    2016-07-26

    In this paper, we consider and examine fog measurement data, coming from several locations in Europe and USA, and attempt to derive a unified model for fog attenuation in free space optics (FSO) communication links. We evaluate and compare the performance of our proposed model to that of many well-known alternative models. We found that our proposed model, achieves an average RMSE that outperforms them by more than 9 dB. Furthermore, we have studied the performance of the FSO system using different performance metrics such as signal-to-noise (SNR) ratio, bit error rate (BER), and channel capacity. Our results show that FSO is a short range technology. Therefore, FSO is expected to find its place in future networks that will have small cell size, i.e., <1 km diameter. Moreover, our investigation shows that under dense fog, it is difficult to maintain a communications link because of the high signal attenuation, which requires switching the communications to RF backup. Our results show that increasing the transmitted power will improve the system performance under light fog. However, under heavy fog, the effect is minor. To enhance the system performance under low visibility range, multi-hop link is used which can enhance the power budget by using short segments links. Using 22 dBm transmitted power, we obtained BER=10-3 over 1 km link length with 600 m visibility range which corresponds to light fog. However, under lower visibility range equals 40 m that corresponds to dense fog, we obtained the same BER but over 200 m link length. © 2016 IEEE.

  12. Genome analysis methods - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods Genome analysis... methods Data detail Data name Genome analysis methods DOI 10.18908/lsdba.nbdc01194-01-005 De...scription of data contents The current status and related information of the genomic analysis about each org...anism (March, 2014). In the case of organisms carried out genomic analysis, the d...e File name: pgdbj_dna_marker_linkage_map_genome_analysis_methods_en.zip File URL: ftp://ftp.biosciencedbc.j

  13. DMFC performance and methanol cross-over: Experimental analysis and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, A.; Marchesi, R. [Dipartimento di Energia, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2008-10-15

    A combined experimental and modelling approach is proposed to analyze methanol cross-over and its effect on DMFC performance. The experimental analysis is performed in order to allow an accurate investigation of methanol cross-over influence on DMFC performance, hence measurements were characterized in terms of uncertainty and reproducibility. The findings suggest that methanol cross-over is mainly determined by diffusion transport and affects cell performance partly via methanol electro-oxidation at the cathode. The modelling analysis is carried out to further investigate methanol cross-over phenomenon. A simple model evaluates the effectiveness of two proposed interpretations regarding methanol cross-over and its effects. The model is validated using the experimental data gathered. Both the experimental analysis and the proposed and validated model allow a substantial step forward in the understanding of the main phenomena associated with methanol cross-over. The findings confirm the possibility to reduce methanol cross-over by optimizing anode feeding. (author)

  14. Operation and management manual of JT-60 experimental data analysis system

    International Nuclear Information System (INIS)

    Hirayama, Takashi; Morishima, Soichi

    2014-03-01

    In the Japan Atomic Energy Agency Naka Fusion Institute, a lot of experiments have been conducted by using the large tokamak device JT-60 aiming to realize fusion power plant. In order to optimize the JT-60 experiment and to investigate complex characteristics of plasma, JT-60 experimental data analysis system was developed and used for collecting, referring and analyzing the JT-60 experimental data. Main components of the system are a data analysis server and a database server for the analyses and accumulation of the experimental data respectively. Other peripheral devices of the system are magnetic disk units, NAS (Network Attached Storage) device, and a backup tape drive. This is an operation and management manual the JT-60 experimental data analysis system. (author)

  15. Beliefs and Ideologies Linked with Approval of Corporal Punishment: A Content Analysis of Online Comments

    Science.gov (United States)

    Taylor, C. A.; Al-Hiyari, R.; Lee, S. J.; Priebe, A.; Guerrero, L. W.; Bales, A.

    2016-01-01

    This study employs a novel strategy for identifying points of resistance to education efforts aimed at reducing rates of child physical abuse and use of corporal punishment (CP). We analyzed online comments (n = 581) generated in response to media coverage of a study linking CP with increased child aggression. Most comments (71%) reflected…

  16. An explorative analysis of the links between learning behavior and change orientation

    NARCIS (Netherlands)

    Sluis, van der E.C. (Lidewey); Caluwé, L.I.A.; Nistelrooij, van A.T.M.

    2005-01-01

    The article presents an explorative study on the links between learning behavior and change orientation of individuals. When reading literature on how to develop employees and organizations, it strikes one how less focus there is on learning and change needs of individuals. This paper deals with

  17. Performance Analysis of FSO Links over Unified Gamma-Gamma Turbulence Channels

    KAUST Repository

    Ansari, Imran Shafique; Yilmaz, Ferkan; Alouini, Mohamed-Slim

    2015-01-01

    , then, present unified exact closed-form expressions for various statistical characteristics of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system. We capitalize on these unified results to offer unified exact closed

  18. Revisiting the Gun Ownership and Violence Link; a multi- level analysis of victimisation survey data.

    NARCIS (Netherlands)

    van Kesteren, J.N.

    2014-01-01

    The link between gun ownership victimisation by violent crime remains one of the most contested issues in criminology. Some authors claim that high gun availability facilitates serious violence. Others claim that gun ownership prevents crime. This article revisits these issues using individual and

  19. Analysis of fog effects on terrestrial Free Space optical communication links

    KAUST Repository

    Esmail, Maged Abdullah; Fathallah, Habib; Alouini, Mohamed-Slim

    2016-01-01

    the transmitted power will improve the system performance under light fog. However, under heavy fog, the effect is minor. To enhance the system performance under low visibility range, multi-hop link is used which can enhance the power budget by using short

  20. Integration and analysis of neighbor discovery and link quality estimation in wireless sensor networks.

    Science.gov (United States)

    Radi, Marjan; Dezfouli, Behnam; Abu Bakar, Kamalrulnizam; Abd Razak, Shukor

    2014-01-01

    Network connectivity and link quality information are the fundamental requirements of wireless sensor network protocols to perform their desired functionality. Most of the existing discovery protocols have only focused on the neighbor discovery problem, while a few number of them provide an integrated neighbor search and link estimation. As these protocols require a careful parameter adjustment before network deployment, they cannot provide scalable and accurate network initialization in large-scale dense wireless sensor networks with random topology. Furthermore, performance of these protocols has not entirely been evaluated yet. In this paper, we perform a comprehensive simulation study on the efficiency of employing adaptive protocols compared to the existing nonadaptive protocols for initializing sensor networks with random topology. In this regard, we propose adaptive network initialization protocols which integrate the initial neighbor discovery with link quality estimation process to initialize large-scale dense wireless sensor networks without requiring any parameter adjustment before network deployment. To the best of our knowledge, this work is the first attempt to provide a detailed simulation study on the performance of integrated neighbor discovery and link quality estimation protocols for initializing sensor networks. This study can help system designers to determine the most appropriate approach for different applications.

  1. Impedance-based Analysis of DC Link Control in Voltage Source Rectifiers

    DEFF Research Database (Denmark)

    Lu, Dapeng; Wang, Xiongfei; Blaabjerg, Frede

    2018-01-01

    This paper analyzes the dynamics influences of the outer dc link control in the voltage source rectifiers based on the impedance model. The ac-dc interactions are firstly presented by means of full order small signal model in dq frame, which shows the input voltage and load condition are the two...

  2. Integration and Analysis of Neighbor Discovery and Link Quality Estimation in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Marjan Radi

    2014-01-01

    Full Text Available Network connectivity and link quality information are the fundamental requirements of wireless sensor network protocols to perform their desired functionality. Most of the existing discovery protocols have only focused on the neighbor discovery problem, while a few number of them provide an integrated neighbor search and link estimation. As these protocols require a careful parameter adjustment before network deployment, they cannot provide scalable and accurate network initialization in large-scale dense wireless sensor networks with random topology. Furthermore, performance of these protocols has not entirely been evaluated yet. In this paper, we perform a comprehensive simulation study on the efficiency of employing adaptive protocols compared to the existing nonadaptive protocols for initializing sensor networks with random topology. In this regard, we propose adaptive network initialization protocols which integrate the initial neighbor discovery with link quality estimation process to initialize large-scale dense wireless sensor networks without requiring any parameter adjustment before network deployment. To the best of our knowledge, this work is the first attempt to provide a detailed simulation study on the performance of integrated neighbor discovery and link quality estimation protocols for initializing sensor networks. This study can help system designers to determine the most appropriate approach for different applications.

  3. ANALYSIS OF SOIL AND DUST SAMPLES FOR POLYCHLORINATED BIPHENYLS BY ENZYME LINKED IMMUNOSORBENT ASSAY (ELISA)

    Science.gov (United States)

    An inhibition enzyme-linked immunosorbent assay (ELISA) was used to determine polychlorinated biphenyls (PCBs) in house dust and soil. Soil and house dust samples were analyzed for PCB by both gas chromatography/electron capture detection (GC/ECD) and ELISA methods. A correlati...

  4. experimental analysis

    African Journals Online (AJOL)

    user

    which included measurements for the determination of the collector efficiency and ... (2012) studied the thermal performance of all-glass evacuated solar ... which features excellent solar radiation absorption and negligible reflection properties.

  5. Marker list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...Database Site Policy | Contact Us Marker list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  6. QTL list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...Policy | Contact Us QTL list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  7. Experimental analysis of the influence of damping on the resonance behavior of a spherical pendulum

    Czech Academy of Sciences Publication Activity Database

    Pospíšil, Stanislav; Fischer, Cyril; Náprstek, Jiří

    2014-01-01

    Roč. 78, č. 1 (2014), s. 371-390 ISSN 0924-090X R&D Projects: GA ČR(CZ) GC13-34405J Grant - others:NSC(TW) 101WFD0400131 Institutional support: RVO:68378297 Keywords : auto -parametric system * experimental verification * spherical pendulum * stability of semi-trivial solution Subject RIV: JM - Building Engineering Impact factor: 2.849, year: 2014 http://link.springer.com/article/10.1007%2Fs11071-014-1446-6#page-1

  8. Analysis by the reductive-cleavage method of linkage positions in a polysaccharide containing 4-linked D-glucopyranosyluronic residues.

    Science.gov (United States)

    Vodonik, S A; Gray, G R

    1988-04-01

    The fate of 4-linked D-glucopyranosyluronic residues under reductive-cleavage conditions was investigated by using the Klebsiella aerogenes type 54 strain A3 capsular polysaccharide. Treatment of the fully methylated polysaccharide with triethylsilane and trimethylsilyl trifluoromethanesulfonate in dichloromethane, followed by in situ acetylation, yielded 1,5-anhydro-2,3,4,6-tetra-O-methyl-D-glucitol, 3,4-di-O-acetyl-1,5-anhydro-2,6-di-O-methyl-D-glucitol, and 3-O-acetyl-1,5-anhydro-2,4-di-O-methyl-L-fucitol, as expected, but the expected product of reductive cleavage of the 4-linked D-glucopyranosyluronic residue, namely, methyl 3-O-acetyl-2,6-anhydro-4,5-di-O-methyl-L-gulonate, was not observed. Instead, methyl 2-O-acetyl-3,6-anhydro-4,5-di-O-methyl-L-gulonate (6) was identified as the sole product of reductive cleavage of the 4-linked D-glucopyranosyluronic residue. That compound 6 arose as a result of rearrangement during reductive cleavage rather than by reductive cleavage of a 5-linked D-glucofuranosyluronic residue, was established by reductive cleavage of the fully methylated polysaccharide following reduction of its ester groups with either lithium aluminum hydride or lithium aluminum deuteride. The products of the latter reductive cleavage were the same as before, except for the absence of 6 and the presence of 4,6-di-O-acetyl-1,5-anhydro-2,3-di-O-methyl-D-glucitol, or its 6,6-dideuterio isomer. Although the reductive-cleavage technique is suitable for the direct analysis of polysaccharides containing 4-linked D-glucopyranosyluronic residues, it does not establish whether the uronic residue is a 4-linked pyranoside or a 5-linked furanoside. The expected product is, however, derived from the 4-linked D-glucopyranosyluronic residue after sequential methylation, reduction of its ester group and reductive cleavage.

  9. Running accuracy analysis of a 3-RRR parallel kinematic machine considering the deformations of the links

    Science.gov (United States)

    Wang, Liping; Jiang, Yao; Li, Tiemin

    2014-09-01

    Parallel kinematic machines have drawn considerable attention and have been widely used in some special fields. However, high precision is still one of the challenges when they are used for advanced machine tools. One of the main reasons is that the kinematic chains of parallel kinematic machines are composed of elongated links that can easily suffer deformations, especially at high speeds and under heavy loads. A 3-RRR parallel kinematic machine is taken as a study object for investigating its accuracy with the consideration of the deformations of its links during the motion process. Based on the dynamic model constructed by the Newton-Euler method, all the inertia loads and constraint forces of the links are computed and their deformations are derived. Then the kinematic errors of the machine are derived with the consideration of the deformations of the links. Through further derivation, the accuracy of the machine is given in a simple explicit expression, which will be helpful to increase the calculating speed. The accuracy of this machine when following a selected circle path is simulated. The influences of magnitude of the maximum acceleration and external loads on the running accuracy of the machine are investigated. The results show that the external loads will deteriorate the accuracy of the machine tremendously when their direction coincides with the direction of the worst stiffness of the machine. The proposed method provides a solution for predicting the running accuracy of the parallel kinematic machines and can also be used in their design optimization as well as selection of suitable running parameters.

  10. Beliefs and ideologies linked with approval of corporal punishment: a content analysis of online comments

    Science.gov (United States)

    Taylor, C. A.; Al-Hiyari, R.; Lee, S. J.; Priebe, A.; Guerrero, L. W.; Bales, A.

    2016-01-01

    This study employs a novel strategy for identifying points of resistance to education efforts aimed at reducing rates of child physical abuse and use of corporal punishment (CP). We analyzed online comments (n = 581) generated in response to media coverage of a study linking CP with increased child aggression. Most comments (71%) reflected approval of hitting children for disciplinary purposes. Reasons for this approval were rooted in beliefs linking the use of CP with positive or neutral outcomes such as: ‘I was spanked and I am okay’, spanking improves child behavior, spanking is more effective than other forms of discipline and spanking is not abuse. However, also linked with approval were more macro-ideological beliefs about society such as: today’s generation is worse off than previous ones, outside interference with parenting is wrong, one cause leads to an outcome, justifications for hitting children rooted in religious doctrine, bad parents cannot control their children and children have too much power. Our results suggest a need to better translate and disseminate empirical findings regarding the negative effects of CP to the public in a way that is highly sensitive to parents’ needs to feel in control and effective when parenting. PMID:27312115

  11. Beliefs and ideologies linked with approval of corporal punishment: a content analysis of online comments.

    Science.gov (United States)

    Taylor, C A; Al-Hiyari, R; Lee, S J; Priebe, A; Guerrero, L W; Bales, A

    2016-08-01

    This study employs a novel strategy for identifying points of resistance to education efforts aimed at reducing rates of child physical abuse and use of corporal punishment (CP). We analyzed online comments (n = 581) generated in response to media coverage of a study linking CP with increased child aggression. Most comments (71%) reflected approval of hitting children for disciplinary purposes. Reasons for this approval were rooted in beliefs linking the use of CP with positive or neutral outcomes such as: 'I was spanked and I am okay', spanking improves child behavior, spanking is more effective than other forms of discipline and spanking is not abuse. However, also linked with approval were more macro-ideological beliefs about society such as: today's generation is worse off than previous ones, outside interference with parenting is wrong, one cause leads to an outcome, justifications for hitting children rooted in religious doctrine, bad parents cannot control their children and children have too much power. Our results suggest a need to better translate and disseminate empirical findings regarding the negative effects of CP to the public in a way that is highly sensitive to parents' needs to feel in control and effective when parenting. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  12. A COMPARATIVE ANALYSIS BETWEEN UNIT-LINKED LIFE INSURANCE AND OTHER ALTERNATIVE INVESTMENTS

    Directory of Open Access Journals (Sweden)

    CRISTINA CIUMAS

    2015-07-01

    Full Text Available The unit-linked life insurance has two important components: protection and investment. The protection component refers to the insured sum in case of the occurrence of insured risks and the investment component refers to the policyholder’s account that represents the present value of the units from the chosen investment funds.These financial products invest most of the premium paid by the insured person in the funds managed by the insurance company or an external administrator and the lower part of the premium is intended to cover the insured risk (death, disability, etc. An important component of the activity carried out by the insurance companies is the investment of the premiums paid by policyholders in various types of assets, in order to obtain higher yields than those guaranteed by the insurance contracts, while providing the necessary liquidity for the payment of insurance claims in case of occurrence of the assumed risks. This research contributes to the existing literature regarding the study of investment alternatives, with an exclusive focus on the investment in unit-linked life insurance. A special place in this study is the presentation of investments in unit-linked insurance versus other types of financial investments: deposits, treasury bills, shares (BET, currency (EURO and gold.

  13. Link Power Budget and Traffict QoS Performance Analysis of Gygabit Passive Optical Network

    Science.gov (United States)

    Ubaidillah, A.; Alfita, R.; Toyyibah

    2018-01-01

    Data service of telecommunication network is needed widely in the world; therefore extra wide bandwidth must be provided. For this case, PT. Telekomunikasi Tbk. applies GPON (Gigabit Passive Optical Network) as optical fibre based on telecommunication network system. GPON is a point to a multipoint technology of FTTx (Fiber to The x) that transmits information signals to the subscriber over optical fibre. In GPON trunking system, from OLT (Optical Line Terminal), the network is split to many ONT (Optical Network Terminal) of the subscribers, so it causes path loss and attenuation. In this research, the GPON performance is measured from the link power budget system and the Quality of Service (QoS) of the traffic. And the observation result shows that the link power budget system of this GPON is in good condition. The link power budget values from the mathematical calculation and direct measurement are satisfy the ITU-T G984 Class B standard, that the power level must be between -8 dBm to -27 dBm. While from the traffic performance, the observation result shows that the network resource utility of the subscribers of the observed area is not optimum. The mean of subscriber utility rate is 27.985 bps for upstream and 79.687 bps for downstream. While maximally, It should be 60.800 bps for upstream and 486.400 bps for downstream.

  14. Development of a system for a linked analysis of RELAP5 and MAAP4 and its application for an analysis of LB-LOCA case of APR1400

    International Nuclear Information System (INIS)

    Park, Chang Hwan; Lee, Un Chul; Park, Goon Cherl; Suh, Kune Yull

    2004-01-01

    The RELAP5 (1995) and MAAP4 (1994) linked-analysis system was designed and illustrative calculation was performed. A large-break loss-of-coolant accident (LBLOCA) was taken as the reference case for the APR1400 (Advanced Power Reactor 1400MWe). For the early phase of this case, the calculational results of two codes have some deviations in water level depletion and hot assembly temperature. Ordinarily, it is considered that RELAP5 has enough accuracy in calculation of the thermal hydraulic behavior of typical PWR during design basis accidents. If the data set for the thermal hydraulic state of RELAP5 can be well-transferred to MAAP4 as an initial condition, the overall transients given by the linked analysis can get more reliability. In this study, the linked analysis system of RELAP5 and MAAP4 doesn't mean the mechanically integrated code structure. The objective of this study is to formulate the linked analysis system of RELAP5 and MAAP4, which should precede construction of mechanically integrated analyzer. Thus, the main scope of this work covers development of the methodology for data linkage and decision of the transfer timing

  15. Advances in the indirect, descriptive, and experimental approaches to the functional analysis of problem behavior.

    Science.gov (United States)

    Wightman, Jade; Julio, Flávia; Virués-Ortega, Javier

    2014-05-01

    Experimental functional analysis is an assessment methodology to identify the environmental factors that maintain problem behavior in individuals with developmental disabilities and in other populations. Functional analysis provides the basis for the development of reinforcement-based approaches to treatment. This article reviews the procedures, validity, and clinical implementation of the methodological variations of functional analysis and function-based interventions. We present six variations of functional analysis methodology in addition to the typical functional analysis: brief functional analysis, single-function tests, latency-based functional analysis, functional analysis of precursors, and trial-based functional analysis. We also present the three general categories of function-based interventions: extinction, antecedent manipulation, and differential reinforcement. Functional analysis methodology is a valid and efficient approach to the assessment of problem behavior and the selection of treatment strategies.

  16. Comprehensive functional analysis of N-linked glycans on Ebola virus GP1.

    Science.gov (United States)

    Lennemann, Nicholas J; Rhein, Bethany A; Ndungo, Esther; Chandran, Kartik; Qiu, Xiangguo; Maury, Wendy

    2014-01-28

    Ebola virus (EBOV) entry requires the virion surface-associated glycoprotein (GP) that is composed of a trimer of heterodimers (GP1/GP2). The GP1 subunit contains two heavily glycosylated domains, the glycan cap and the mucin-like domain (MLD). The glycan cap contains only N-linked glycans, whereas the MLD contains both N- and O-linked glycans. Site-directed mutagenesis was performed on EBOV GP1 to systematically disrupt N-linked glycan sites to gain an understanding of their role in GP structure and function. All 15 N-glycosylation sites of EBOV GP1 could be removed without compromising the expression of GP. The loss of these 15 glycosylation sites significantly enhanced pseudovirion transduction in Vero cells, which correlated with an increase in protease sensitivity. Interestingly, exposing the receptor-binding domain (RBD) by removing the glycan shield did not allow interaction with the endosomal receptor, NPC1, indicating that the glycan cap/MLD domains mask RBD residues required for binding. The effects of the loss of GP1 N-linked glycans on Ca(2+)-dependent (C-type) lectin (CLEC)-dependent transduction were complex, and the effect was unique for each of the CLECs tested. Surprisingly, EBOV entry into murine peritoneal macrophages was independent of GP1 N-glycans, suggesting that CLEC-GP1 N-glycan interactions are not required for entry into this important primary cell. Finally, the removal of all GP1 N-glycans outside the MLD enhanced antiserum and antibody sensitivity. In total, our results provide evidence that the conserved N-linked glycans on the EBOV GP1 core protect GP from antibody neutralization despite the negative impact the glycans have on viral entry efficiency. Filovirus outbreaks occur sporadically throughout central Africa, causing high fatality rates among the general public and health care workers. These unpredictable hemorrhagic fever outbreaks are caused by multiple species of Ebola viruses, as well as Marburg virus. While filovirus

  17. Advancements in mass spectrometry for biological samples: Protein chemical cross-linking and metabolite analysis of plant tissues

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Adam [Iowa State Univ., Ames, IA (United States)

    2015-01-01

    This thesis presents work on advancements and applications of methodology for the analysis of biological samples using mass spectrometry. Included in this work are improvements to chemical cross-linking mass spectrometry (CXMS) for the study of protein structures and mass spectrometry imaging and quantitative analysis to study plant metabolites. Applications include using matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to further explore metabolic heterogeneity in plant tissues and chemical interactions at the interface between plants and pests. Additional work was focused on developing liquid chromatography-mass spectrometry (LC-MS) methods to investigate metabolites associated with plant-pest interactions.

  18. Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis

    Directory of Open Access Journals (Sweden)

    Renzhi Wang

    2016-09-01

    Full Text Available Adrenocorticotrophin (ACTH-secreting pituitary adenoma, also known as Cushing disease (CD, is rare and causes metabolic syndrome, cardiovascular disease and osteoporosis due to hypercortisolism. However, the molecular pathogenesis of CD is still unclear because of a lack of human cell lines and animal models. Here, we study 106 clinical characteristics and gene expression changes from 118 patients, the largest cohort of CD in a single-center. RNA deep sequencing is used to examine genotypic changes in nine paired female ACTH-secreting pituitary adenomas and adjacent nontumorous pituitary tissues (ANPT. We develop a novel analysis linking disease clinical characteristics and whole transcriptomic changes, using Pearson Correlation Coefficient to discover a molecular network mechanism. We report that osteoporosis is distinguished from the phenotype and genotype analysis. A cluster of genes involved in osteoporosis is identified using Pearson correlation coefficient analysis. Most of the genes are reported in the bone related literature, confirming the feasibility of phenotype-genotype association analysis, which could be used in the analysis of almost all diseases. Secreted phosphoprotein 1 (SPP1, collagen type I α 1 chain (COL1A1, 5′-nucleotidase ecto (NT5E, HtrA serine peptidase 1 (HTRA1 and angiopoietin 1 (ANGPT1 and their signalling pathways are shown to be involved in osteoporosis in CD patients. Our discoveries provide a molecular link for osteoporosis in CD patients, and may open new potential avenues for osteoporosis intervention and treatment.

  19. Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder.

    Science.gov (United States)

    Le Hellard, Stephanie; Lee, Andrew J; Underwood, Sarah; Thomson, Pippa A; Morris, Stewart W; Torrance, Helen S; Anderson, Susan M; Adams, Richard R; Navarro, Pau; Christoforou, Andrea; Houlihan, Lorna M; Detera-Wadleigh, Sevilla; Owen, Michael J; Asherson, Philip; Muir, Walter J; Blackwood, Douglas H R; Wray, Naomi R; Porteous, David J; Evans, Kathryn L

    2007-03-15

    Bipolar affective disorder (BPAD) and schizophrenia (SCZ) are common conditions. Their causes are unknown, but they include a substantial genetic component. Previously, we described significant linkage of BPAD to a chromosome 4p locus within a large pedigree (F22). Others subsequently have found evidence for linkage of BPAD and SCZ to this region. We constructed high-resolution haplotypes for four linked families, calculated logarithm of the odds (LOD) scores, and developed a novel method to assess the extent of allele sharing within genes between the families. We describe an increase in the F22 LOD score for this region. Definition and comparison of the linked haplotypes allowed us to prioritize two subregions of 3.8 and 4.4 Mb. Analysis of the extent of allele sharing within these subregions identified 200 kb that shows increased allele sharing between families. Linkage of BPAD to chromosome 4p has been strengthened. Haplotype analysis in the additional linked families refined the 20-Mb linkage region. Development of a novel allele-sharing method allowed us to bridge the gap between conventional linkage and association studies. Description of a 200-kb region of increased allele sharing prioritizes this region, which contains two functional candidate genes for BPAD, SLC2A9, and WDR1, for subsequent studies.

  20. Conformational analysis of a covalently cross-linked Watson-Crick base pair model.

    Science.gov (United States)

    Jensen, Erik A; Allen, Benjamin D; Kishi, Yoshito; O'Leary, Daniel J

    2008-11-15

    Low-temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Crick hydrogen bonding geometries have similar energies and can interconvert at low temperatures. This low-temperature process involves rotation about the crosslink CH(2)C(5') (psi) carbon-carbon bond, which is energetically preferred over the alternate CH(2)N(3) (phi) carbon-nitrogen bond rotation.

  1. Conformational Analysis of a Covalently Cross-Linked Watson-Crick Base Pair Model

    OpenAIRE

    Jensen, Erik A.; Allen, Benjamin D.; Kishi, Yoshito; O'Leary, Daniel J.

    2008-01-01

    Low temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Crick hydrogen bonding geometries have similar energies and can interconvert at low temperatures. This low-temperature process involves rotation about the crosslink CH2–C(5′) (ψ) carbon-carbon bond, which is energetically preferred over the alternate CH2–N(3) (ϕ) carbon-nitrogen ...

  2. Analysis of control alternatives for offshore wind farms connected through a VSC-HVDC link

    Energy Technology Data Exchange (ETDEWEB)

    Belenguer, Enrique; Vidal, Ricardo; Beltran, Hector [Jaume I Univ., Castellon de la Plana (Spain). Dept. of Industrial Engineering Systems; Blasco-Gimenez, Ramon [Univ. Politecnica de Valencia (Spain). Dept. of Systems Engineering and Control

    2012-07-01

    The use of VSC-HVDC transmission systems for the connection of offshore wind power plants increases the control capabilities of the whole system with respect to the use of standard LCC-HVDC systems. In this paper two different control strategies for an offshore wind farm connected through a VSC-HVDC link have been developed and analyzed through PSCAD simulations. Both, steady state and transient behavior have been simulated in order to find the best control strategy for such a system. (orig.)

  3. Hydrodynamics of back spatter by blunt bullet gunshot with a link to bloodstain pattern analysis

    Science.gov (United States)

    Comiskey, P. M.; Yarin, A. L.; Attinger, D.

    2017-07-01

    A theoretical model describing the blood spatter pattern resulting from a blunt bullet gunshot is proposed. The predictions are compared to experimental data acquired in the present work. This hydrodynamic problem belongs to the class of the impact hydrodynamics with the pressure impulse generating the blood flow. At the free surface, the latter is directed outwards and accelerated toward the surrounding air. As a result, the Rayleigh-Taylor instability of the flow of blood occurs, which is responsible for the formation of blood drops of different sizes and initial velocities. Thus, the initial diameter, velocity, and acceleration of the atomized blood drops can be determined. Then, the equations of motion are solved, describing drop trajectories in air accounting for gravity, and air drag. Also considered are the drop-drop interactions through air, which diminish air drag on the subsequent drops. Accordingly, deposition of two-phase (blood-drop and air) jets on a vertical cardstock sheet located between the shooter and the target (and perforated by the bullet) is predicted and compared with experimental data. The experimental data were acquired with a porous polyurethane foam sheet target impregnated with swine blood, and the blood drops were collected on a vertical cardstock sheet which was perforated by the blunt bullet. The highly porous target possesses a low hydraulic resistance and therefore resembles a pool of blood shot by a blunt bullet normally to its free surface. The back spatter pattern was predicted numerically and compared to the experimental data for the number of drops, their area, the total stain area, and the final impact angle as functions of radial location from the bullet hole in the cardstock sheet (the collection screen). Comparisons of the predicted results with the experimental data revealed satisfactory agreement. The predictions also allow one to find the impact Weber number on the collection screen, which is necessary to predict stain

  4. Experimental assessment of computer codes used for safety analysis of integral reactors

    Energy Technology Data Exchange (ETDEWEB)

    Falkov, A.A.; Kuul, V.S.; Samoilov, O.B. [OKB Mechanical Engineering, Nizhny Novgorod (Russian Federation)

    1995-09-01

    Peculiarities of integral reactor thermohydraulics in accidents are associated with presence of noncondensable gas in built-in pressurizer, absence of pumped ECCS, use of guard vessel for LOCAs localisation and passive RHRS through in-reactor HX`s. These features defined the main trends in experimental investigations and verification efforts for computer codes applied. The paper reviews briefly the performed experimental investigation of thermohydraulics of AST-500, VPBER600-type integral reactors. The characteristic of UROVEN/MB-3 code for LOCAs analysis in integral reactors and results of its verification are given. The assessment of RELAP5/mod3 applicability for accident analysis in integral reactor is presented.

  5. Finite Element Analysis for Active-force Control on Vibration of a Flexible Single-link Manipulator

    Directory of Open Access Journals (Sweden)

    Abdul Kadir Muhammad

    2017-03-01

    Full Text Available The purposes of this research are to formulate theequations of motion of the system, to develop computationalcodes by a finite element analysis in order to perform dynamicssimulation with vibration control, to propose an effective controlscheme using active-force (AF control a flexible single-linkmanipulator. The system used in this paper consists of analuminum beam as a flexible link, a clamp-part, a servo motor torotate the link and a piezoelectric actuator to control vibration.Computational codes on time history responses, FFT (FastFourier Transform processing and eigenvalues-eigenvectorsanalysis were developed to calculate dynamic behavior of thelink. Furthermore, the AF control was designed to drive thepiezoelectric actuator. Calculated results have revealed that thevibration of the system can be suppressed effectively

  6. Radiostereometric analysis comparison of wear of highly cross-linked polyethylene against 36- vs 28-mm femoral heads.

    Science.gov (United States)

    Bragdon, Charles R; Greene, Meridith E; Freiberg, Andrew A; Harris, William H; Malchau, Henrik

    2007-09-01

    This study used radiostereometric analysis (RSA) to compare the femoral head penetration of 28- vs 36-mm-diameter femoral heads into highly cross-linked polyethylene in 2 groups of total hip arthroplasty patients. Thirty patients were enrolled in this RSA study using highly cross-linked polyethylene (Longevity, Zimmer Inc, Warsaw, Idaho) against either 28- or 36-mm-diameter cobalt chrome femoral heads. At 3-year follow-up, there was no significant difference in the total average femoral head penetration, including both creep and wear, using 3 methods of RSA measurement between the 2 groups. Importantly, after bedding-in, there was no further significant increase in the amount of femoral head penetration (ie, wear) with either head size between years 1 and 3. There were no radiographic signs of lysis or radiolucencies at a minimum 3-year follow-up.

  7. Analysis of HR consultants and French recruiters activity on LinkedIn. In between work resource and quest of identity development

    Directory of Open Access Journals (Sweden)

    Hélène HOBLINGRE

    2016-12-01

    Full Text Available This article investigates usage of LinkedIn by HR professionals. Based on twelve HR consultants and recruiters interviews, LinkedIn usage analysis highlights that this tool is used in a mix of private and professional practices. It sheds a light on the tension of using LinkedIn as a business tool versus LinkedIn as a tool to develop personal projects. Using LinkedIn in a professional context implies following norms and guidelines that impact user freedom. As a consequence, this prevents user from benefiting from all LinkedIn developmental capabilities. Eventually, our results stress the need for an individual to use LinkedIn as a reflective practitioner. This should be done in the light of building purpose to professional activities and accommodating functional usage with strategic practices.

  8. The likelihood ratio as a random variable for linked markers in kinship analysis.

    Science.gov (United States)

    Egeland, Thore; Slooten, Klaas

    2016-11-01

    The likelihood ratio is the fundamental quantity that summarizes the evidence in forensic cases. Therefore, it is important to understand the theoretical properties of this statistic. This paper is the last in a series of three, and the first to study linked markers. We show that for all non-inbred pairwise kinship comparisons, the expected likelihood ratio in favor of a type of relatedness depends on the allele frequencies only via the number of alleles, also for linked markers, and also if the true relationship is another one than is tested for by the likelihood ratio. Exact expressions for the expectation and variance are derived for all these cases. Furthermore, we show that the expected likelihood ratio is a non-increasing function if the recombination rate increases between 0 and 0.5 when the actual relationship is the one investigated by the LR. Besides being of theoretical interest, exact expressions such as obtained here can be used for software validation as they allow to verify the correctness up to arbitrary precision. The paper also presents results and advice of practical importance. For example, we argue that the logarithm of the likelihood ratio behaves in a fundamentally different way than the likelihood ratio itself in terms of expectation and variance, in agreement with its interpretation as weight of evidence. Equipped with the results presented and freely available software, one may check calculations and software and also do power calculations.

  9. Linked analysis for definition of nurse advice line syndrome groups, and comparison to encounters.

    Science.gov (United States)

    Magruder, Steven F; Henry, J; Snyde, M

    2005-08-26

    Nurse advice call centers are a potentially important source of data for syndromic surveillance purposes. For this reason, researchers at Johns Hopkins University Applied Physics Laboratory and Kaiser Permanente of the Mid-Atlantic States (KPMAS) have been collaborating to develop methods to use this data within the ESSENCE II Syndromic Surveillance System in the National Capital Region. The objective of this report is to present a general method for finding syndrome groups in data sources that can be linked to physician encounters and to determine effective advice call syndrome groups for use with KPMAS advice data. Advice calls are linked to physician encounters and stratified by patient age. They are placed in groups according to a maximum positive predictive value criterion. The groups are evaluated by correlating the resulting syndrome time series against physician encounter data. Potentially useful advice syndrome groups are found for respiratory, lower gastrointestinal (GI), and total GI syndromes for each age stratum. The time series of the advice data for respiratory, lower GI, and upper GI syndromes accurately predict the physician encounter time series for the corresponding syndromes for each age stratum.

  10. An Introduction to Sensitivity Analysis for Unobserved Confounding in Non-Experimental Prevention Research

    Science.gov (United States)

    Kuramoto, S. Janet; Stuart, Elizabeth A.

    2013-01-01

    Despite that randomization is the gold standard for estimating causal relationships, many questions in prevention science are left to be answered through non-experimental studies often because randomization is either infeasible or unethical. While methods such as propensity score matching can adjust for observed confounding, unobserved confounding is the Achilles heel of most non-experimental studies. This paper describes and illustrates seven sensitivity analysis techniques that assess the sensitivity of study results to an unobserved confounder. These methods were categorized into two groups to reflect differences in their conceptualization of sensitivity analysis, as well as their targets of interest. As a motivating example we examine the sensitivity of the association between maternal suicide and offspring’s risk for suicide attempt hospitalization. While inferences differed slightly depending on the type of sensitivity analysis conducted, overall the association between maternal suicide and offspring’s hospitalization for suicide attempt was found to be relatively robust to an unobserved confounder. The ease of implementation and the insight these analyses provide underscores sensitivity analysis techniques as an important tool for non-experimental studies. The implementation of sensitivity analysis can help increase confidence in results from non-experimental studies and better inform prevention researchers and policymakers regarding potential intervention targets. PMID:23408282

  11. Analysis of experimental data on relativistic nuclear collisions in the Lobachevsky space

    International Nuclear Information System (INIS)

    Baldin, A.A.; Baldina, Eh.G.; Kladnitskaya, E.N.; Rogachevskij, O.V.

    2004-01-01

    Relativistic nuclear collisions are considered in terms of relative 4-velocity and rapidity space (the Lobachevsky space). The connection between geometric relations in the Lobachevsky space and measurable (experimentally determined) kinematic characteristics (transverse momentum, longitudinal rapidity, square relative 4-velocity b ik , etc.) is discussed. The experimental data obtained using the propane bubble chamber are analyzed on the basis of triangulation in the Lobachevsky space. General properties of relativistic invariants distributions characterizing the geometric position of particles in the Lobachevsky space are discussed. The transition energy region is considered on the basis of relativistic approach to experimental data on multiparticle processes. Possible applications of the obtained results for planning of experimental research and analysis of data on multiple particle production are discussed

  12. Linking renewable energy CDM projects and TGC schemes: An analysis of different options

    Energy Technology Data Exchange (ETDEWEB)

    Del Rio, Pablo [Department of Economics and Business, Facultad de Ciencias Juridicas y Sociales, Universidad de Castilla-La Mancha, C/ Cobertizo de S. Pedro Martir s/n., Toledo-45071 (Spain)]. E-mail: pablo.rio@uclm.es

    2006-11-15

    Renewable energy CDM (RE-CDM) projects encourage cost-effective GHG mitigation and enhanced sustainable development opportunities for the host countries. CERs from CDM projects include the value of the former benefits (i.e., 'climate change benefits'), whereas the second can be given value through the issuing and trading of tradable green certificates (TGCs). Countries could agree to trade these TGCs, leading to additional revenues for the investors in renewable energy projects and, therefore, further encouraging the deployment of CDM projects, currently facing significant barriers. However, the design of a combination of CDM projects and TGC schemes raises several conflicting issues and leads to trade-offs. This paper analyses these issues, identifies the alternatives that may exist to link TGC schemes with RE-CDM projects and analyses the impacts of those options on different variables and actors.

  13. Linking renewable energy CDM projects and TGC schemes: An analysis of different options

    International Nuclear Information System (INIS)

    Del Rio, Pablo

    2006-01-01

    Renewable energy CDM (RE-CDM) projects encourage cost-effective GHG mitigation and enhanced sustainable development opportunities for the host countries. CERs from CDM projects include the value of the former benefits (i.e., 'climate change benefits'), whereas the second can be given value through the issuing and trading of tradable green certificates (TGCs). Countries could agree to trade these TGCs, leading to additional revenues for the investors in renewable energy projects and, therefore, further encouraging the deployment of CDM projects, currently facing significant barriers. However, the design of a combination of CDM projects and TGC schemes raises several conflicting issues and leads to trade-offs. This paper analyses these issues, identifies the alternatives that may exist to link TGC schemes with RE-CDM projects and analyses the impacts of those options on different variables and actors

  14. Design and Analysis of Stepped DC Link Hybrid Converter for Solar PV Systems

    Directory of Open Access Journals (Sweden)

    R. Uthirasamy

    2017-09-01

    Full Text Available A structure of single phase DC Link Multilevel H-Bridge Inverter (DCLMLHBI is proposed for symmetrical Photo Voltaic (PV systems. Voltage stress across the inverter switches, Power Spectral Density (PSD, voltage and current harmonics are reduced in the proposed configuration. Compared with conventional 13-level Cascaded Multilevel Inverter (CMLI configuration, the proposed system configuration is structured with less number of series connected power switches and gate drive circuits. None of the passive components are utilized in the proposed inverter configuration, which highlight the significance of the proposed system. The performance parameters are investigated through Phase Opposition Pulse Width Modulation (POD-PWM switching scheme and its results are validated with computer simulation and prototype hardware models.

  15. Analysis and presentation of experimental results with examples, problems and programs

    CERN Document Server

    Christodoulides, Costas

    2017-01-01

    This book is intended as a guide to the analysis and presentation of experimental results. It develops various techniques for the numerical processing of experimental data, using basic statistical methods and the theory of errors. After presenting basic theoretical concepts, the book describes the methods by which the results can be presented, both numerically and graphically. The book is divided into three parts, of roughly equal length, addressing the theory, the analysis of data, and the presentation of results. Examples are given and problems are solved using the Excel, Origin, Python and R software packages. In addition, programs in all four languages are made available to readers, allowing them to use them in analyzing and presenting the results of their own experiments. Subjects are treated at a level appropriate for undergraduate students in the natural sciences, but this book should also appeal to anyone whose work involves dealing with experimental results.

  16. On the Performance Analysis of Free-Space Optical Links under Generalized Turbulence and Misalignment Models

    KAUST Repository

    AlQuwaiee, Hessa

    2016-11-01

    One of the potential solutions to the radio frequency (RF) spectrum scarcity problem is optical wireless communications (OWC), which utilizes the unlicensed optical spectrum. Long-range outdoor OWC are usually referred to in the literature as free-space optical (FSO) communications. Unlike RF systems, FSO is immune to interference and multi-path fading. Also, the deployment of FSO systems is flexible and much faster than optical fibers. These attractive features make FSO applicable for broadband wireless transmission such as optical fiber backup, metropolitan area network, and last mile access. Although FSO communication is a promising technology, it is negatively affected by two physical phenomenon, namely, scintillation due to atmospheric turbulence and pointing errors. These two critical issues have prompted intensive research in the last decade. To quantify the effect of these two factors on FSO system performance, we need effective mathematical models. In this work, we propose and study a generalized pointing error model based on the Beckmann distribution. Then, we aim to generalize the FSO channel model to span all turbulence conditions from weak to strong while taking pointing errors into consideration. Since scintillation in FSO is analogous to the fading phenomena in RF, diversity has been proposed too to overcome the effect of irradiance fluctuations. Thus, several combining techniques of not necessarily independent dual-branch free-space optical links were investigated over both weak and strong turbulence channels in the presence of pointing errors. On another front, improving the performance, enhancing the capacity and reducing the delay of the communication link has been the motivation of any newly developed schemes, especially for backhauling. Recently, there has been a growing interest in practical systems to integrate RF and FSO technologies to solve the last mile bottleneck. As such, we also study in this thesis asymmetric an RF-FSO dual-hop relay

  17. Systematic Comparison of Reverse Phase and Hydrophilic Interaction Liquid Chromatography Platforms for the Analysis of N-linked Glycans

    Science.gov (United States)

    Walker, S. Hunter; Carlisle, Brandon C.; Muddiman, David C.

    2013-01-01

    Due to the hydrophilic nature of glycans, reverse phase chromatography has not been widely used as a glycomic separation technique coupled to mass spectrometry. Other approaches such as hydrophilic interaction chromatography and porous graphitized carbon chromatography are often employed, though these strategies frequently suffer from decreased chromatographic resolution, long equilibration times, indefinite retention, and column bleed. Herein, it is shown that through an efficient hydrazone formation derivatization of N-linked glycans (∼4 hr of additional sample preparation time which is carried out in parallel), numerous experimental and practical advantages are gained when analyzing the glycans by online reverse phase chromatography. These benefits include an increased number of glycans detected, increased peak capacity of the separation, and the ability to analyze glycans on the identical liquid chromatography-mass spectrometry platform commonly used for proteomic analyses. The data presented show that separation of derivatized N-linked glycans by reverse phase chromatography significantly out-performs traditional separation of native or derivatized glycans by hydrophilic interaction chromatography. Furthermore, the movement to a more ubiquitous separation technique will afford numerous research groups the opportunity to analyze both proteomic and glycomic samples on the same platform with minimal time and physical change between experiments, increasing the efficiency of ‘multi-omic’ biological approaches. PMID:22954204

  18. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, Oliver [Technical Univ. of Darmstadt (Germany)

    2009-11-20

    Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle

  19. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    International Nuclear Information System (INIS)

    Ruebel, Oliver

    2009-01-01

    Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle

  20. Experimental display of Fourier analysis through the optical physics and its didatical utilization

    International Nuclear Information System (INIS)

    Oliveira, S.M.M. de.

    1983-01-01

    The properties of Fourier analysis through physical optics are displayed experimentally. Within physical optics topics that illustrate didactically Fourier analysis, a subject usually considered purely mathematical are selected. The most important properties of Fourier transform and their utilization in cleaning up images through spatial filtering are presented, in this way the properties of convolution to analyse image formation and characterize some diffraction patterns are also used. (Author) [pt

  1. Determinants for swine mycoplasmal pneumonia reproduction under experimental conditions: A systematic review and recursive partitioning analysis

    Science.gov (United States)

    Garcia-Morante, Beatriz; Segalés, Joaquim; Serrano, Emmanuel

    2017-01-01

    One of the main Mycoplasma hyopneumoniae (M. hyopneumoniae) swine experimental model objectives is to reproduce mycoplasmal pneumonia (MP). Unfortunately, experimental validated protocols to maximize the chance to successfully achieve lung lesions induced by M. hyopneumoniae are not available at the moment. Thus, the objective of this work was to identify those factors that might have a major influence on the effective development of MP, measured as macroscopic lung lesions, under experimental conditions. Data from 85 studies describing M. hyopneumoniae inoculation experiments were compiled by means of a systematic review and analyzed thereafter. Several variables were considered in the analyses such as the number of pigs in the experiment, serological status against M. hyopneumoniae, source of the animals, age at inoculation, type of inoculum, strain of M. hyopneumoniae, route, dose and times of inoculation, study duration and co-infection with other swine pathogens. Descriptive statistics were used to depict M. hyopneumoniae experimental model main characteristics whereas a recursive partitioning approach, using regression trees, assessed the importance of the abovementioned experimental variables as MP triggering factors. A strong link between the time period between challenge and necropsies and lung lesion severity was observed. Results indicated that the most important factors to explain the observed lung lesion score variability were: (1) study duration, (2) M. hyopneumoniae strain, (3) age at inoculation, (4) co-infection with other swine pathogens and (5) animal source. All other studied variables were not relevant to explain the variability on M. hyopneumoniae lung lesions. The results provided in the present work may serve as a basis for debate in the search for a universally accepted M. hyopneumoniae challenge model. PMID:28742802

  2. Determinants for swine mycoplasmal pneumonia reproduction under experimental conditions: A systematic review and recursive partitioning analysis.

    Directory of Open Access Journals (Sweden)

    Beatriz Garcia-Morante

    Full Text Available One of the main Mycoplasma hyopneumoniae (M. hyopneumoniae swine experimental model objectives is to reproduce mycoplasmal pneumonia (MP. Unfortunately, experimental validated protocols to maximize the chance to successfully achieve lung lesions induced by M. hyopneumoniae are not available at the moment. Thus, the objective of this work was to identify those factors that might have a major influence on the effective development of MP, measured as macroscopic lung lesions, under experimental conditions. Data from 85 studies describing M. hyopneumoniae inoculation experiments were compiled by means of a systematic review and analyzed thereafter. Several variables were considered in the analyses such as the number of pigs in the experiment, serological status against M. hyopneumoniae, source of the animals, age at inoculation, type of inoculum, strain of M. hyopneumoniae, route, dose and times of inoculation, study duration and co-infection with other swine pathogens. Descriptive statistics were used to depict M. hyopneumoniae experimental model main characteristics whereas a recursive partitioning approach, using regression trees, assessed the importance of the abovementioned experimental variables as MP triggering factors. A strong link between the time period between challenge and necropsies and lung lesion severity was observed. Results indicated that the most important factors to explain the observed lung lesion score variability were: (1 study duration, (2 M. hyopneumoniae strain, (3 age at inoculation, (4 co-infection with other swine pathogens and (5 animal source. All other studied variables were not relevant to explain the variability on M. hyopneumoniae lung lesions. The results provided in the present work may serve as a basis for debate in the search for a universally accepted M. hyopneumoniae challenge model.

  3. A task analysis-linked approach for integrating the human factor in reliability assessments of nuclear power plants

    International Nuclear Information System (INIS)

    Ryan, T.G.

    1988-01-01

    This paper describes an emerging Task Analysis-Linked Evaluation Technique (TALENT) for assessing the contributions of human error to nuclear power plant systems unreliability and risk. Techniques such as TALENT are emerging as a recognition that human error is a primary contributor to plant safety, however, it has been a peripheral consideration to data in plant reliability evaluations. TALENT also recognizes that involvement of persons with behavioral science expertise is required to support plant reliability and risk analyses. A number of state-of-knowledge human reliability analysis tools are also discussed which support the TALENT process. The core of TALENT is comprised of task, timeline and interface analysis data which provide the technology base for event and fault tree development, serve as criteria for selecting and evaluating performance shaping factors, and which provide a basis for auditing TALENT results. Finally, programs and case studies used to refine the TALENT process are described along with future research needs in the area. (author)

  4. 15N/14N isotopic ratio and statistical analysis: an efficient way of linking seized Ecstasy tablets

    International Nuclear Information System (INIS)

    Palhol, Fabien; Lamoureux, Catherine; Chabrillat, Martine; Naulet, Norbert

    2004-01-01

    In this study, the 15 N/ 14 N isotopic ratios of 106 samples of 3,4-methylenedioxymethamphetamine (MDMA) extracted from Ecstasy tablets are presented. These ratios, measured using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS), show a large discrimination between samples with a range of δ 15 N values between -17 and +19%o, depending on the precursors and the method used in clandestine laboratories. Thus, δ 15 N values can be used in a statistical analysis carried out in order to link Ecstasy tablets prepared with the same precursors and synthetic pathway. The similarity index obtained after principal component analysis and hierarchical cluster analysis appears to be an efficient way to group tablets seized in different places

  5. {sup 15}N/{sup 14}N isotopic ratio and statistical analysis: an efficient way of linking seized Ecstasy tablets

    Energy Technology Data Exchange (ETDEWEB)

    Palhol, Fabien; Lamoureux, Catherine; Chabrillat, Martine; Naulet, Norbert

    2004-05-10

    In this study, the {sup 15}N/{sup 14}N isotopic ratios of 106 samples of 3,4-methylenedioxymethamphetamine (MDMA) extracted from Ecstasy tablets are presented. These ratios, measured using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS), show a large discrimination between samples with a range of {delta}{sup 15}N values between -17 and +19%o, depending on the precursors and the method used in clandestine laboratories. Thus, {delta}{sup 15}N values can be used in a statistical analysis carried out in order to link Ecstasy tablets prepared with the same precursors and synthetic pathway. The similarity index obtained after principal component analysis and hierarchical cluster analysis appears to be an efficient way to group tablets seized in different places.

  6. Linkage analysis in a Dutch family with X-linked recessive congenital stationary night blindness (XL-CSNB).

    Science.gov (United States)

    Berger, W; van Duijnhoven, G; Pinckers, A; Smits, A; Ropers, H H; Cremers, F

    1995-01-01

    Linkage analysis has been performed in a large Dutch pedigree with X-linked recessive congenital stationary night blindness (CSNB) by utilizing 16 DNA markers from the proximal short arm of the human X chromosome (Xp21.1-11.2). Thirteen polymorphic markers are at least partially informative and have enabled pairwise and multipoint linkage analysis. For three loci, i.e. DXS228, the monoamine oxidase B gene and the Norrie disease gene (NDG), multipoint linkage studies have yielded maximum lod scores of > 3.0 at a recombination fraction of zero. Analysis of recombination events has enabled us to rule out the possibility that the underlying defect in this family is allelic to RP3; the gene defect could also be excluded from the proximal part of the region known to carry RP2. Linkage data are consistent with a possible involvement of the NDG but mutations in the open reading frame of this gene have not been found.

  7. Stratified spherical model for microwave imaging of the brain: Analysis and experimental validation of transmitted power

    DEFF Research Database (Denmark)

    Bjelogrlic, Mina; Volery, Maxime; Fuchs, Benjamin

    2018-01-01

    This work presents the analysis of power transmission of a radiating field inside the human head for microwave imaging applications. For this purpose, a spherical layered model composed of dispersive biological tissues is investigated in the range of (0.5–4) GHz and is confronted to experimental ...

  8. The Etymology of Basic Concepts in the Experimental Analysis of Behavior

    Science.gov (United States)

    Dinsmoor, James A.

    2004-01-01

    The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his…

  9. F.E. analysis of seismic isolators: comparison with experimental results

    International Nuclear Information System (INIS)

    Fuller, K.N.G.; Gough, J.; Ahmadi, H.R.

    1998-01-01

    Analysis of seismic isolators is performed by the ABAQUS code. The force deformation behaviour of a circular layer of rubber bonded to rigid surface was investigated. This model is chosen because of its simplicity and the relatively short processing time required. A 3-dimensional model was used for finite element calculations. Comparison of calculated values with experimental results is shown

  10. Tribology of skin : review and analysis of experimental results for the friction coefficient of human skin

    NARCIS (Netherlands)

    Derler, S.; Gerhardt, L.C.

    2012-01-01

    In this review, we discuss the current knowledge on the tribology of human skin and present an analysis of the available experimental results for skin-friction coefficients. Starting with an overview on the factors influencing the friction behaviour of skin, we discuss the up-to-date existing

  11. Experimental Demonstration and Theoretical Analysis of Slow Light in a Semiconductor Waveguide at GHz Frequencies

    DEFF Research Database (Denmark)

    Mørk, Jesper; Kjær, Rasmus; Poel, Mike van der

    2005-01-01

    Experimental demonstration and theoretical analysis of slow light in a semiconductor waveguide at GHz frequencies slow-down of light by a factor of two in a semiconductor waveguide at room temperature with a bandwidth of 16.7 GHz using the effect of coherent pulsations of the carrier density...

  12. Experimental determination of the fluid velocity by spectral analysis of temperature fluctuations

    International Nuclear Information System (INIS)

    Foucrier, M.J.; Faya, A.J.G.

    1988-12-01

    Local velocities of turbulent closed channel flow were measured applying the noise analysis technique to signals coming from two sensors separated by a know distance. Good agreement was found when comparing experimental data to more accurate measurements. Ranges of Reynolds number and thermocouple spacial separation are recommended. (author) [pt

  13. Numerical and on-site experimental dynamic analysis of the Italian PEC fast reactor building

    International Nuclear Information System (INIS)

    Castoldi, A.; Muzzi, F.; Orsi, R.; Panzeri, P.; Pezzoli, P.; Ruggeri, G.; Martelli, A.; Masoni, P.; Brancati, V.

    1988-01-01

    On-site dynamic tests and three-dimensional numerical analysis have been performed by ISMES on behalf of ENEA on the building of the Italian PEC fast reactor test facility. These studies aimed at evaluating the safety margins in the PEC reactor seismic analysis and at providing data for the optimization of the PEC seismic monitoring system. The paper describes the on-site dynamic tests carried out using various excitation methods (two eccentric back-rotating-mass mechanical vibrator, blasting in bore-hole and hydraulic actuators at the building foundations). It highlights the purposes of the four tests campaigns performed at various construction stages and reports the main experimental results. In connection with the experimental tests, a detailed 3D finite element model was set up for fixed base analysis; from the results of the 3D model a simplified equivalent model of the structure was then derived for soil-structure interaction analysis. The mathematical model was validated and calibrated by using the results of the experimental dynamic tests. The main numerical results and the comparisons with the experimental data are presented. (author)

  14. Reflections on the glass ceiling: women in the experimental analysis of behavior.

    Science.gov (United States)

    Odum, A L

    2000-01-01

    McSweeney and Swindell (1998) sought to determine whether men and women are treated equitably in the experimental analysis of behavior. They purported to show that women participate less in the Journal of the Experimental Analysis of Behavior than in similar journals and that the participation of women decreases with increases in selectivity. Their data were difficult to interpret, however, because they did not present the variability in the mean data drawn from different individuals over time. My analyses were not in accord with their conclusions. When the percentage of associate editors who are women was considered along with the mean percentages McSweeney and Swindell reported for other measures, participation did not systematically decrease with increases in selectivity in recent years. As quantified in terms of their number of publications in the Journal of the Experimental Analysis of Behavior, women who were editorial board members and associate editors were not more highly selected than their male counterparts. Finally, in the recent period from 1996 to 1998, although women submitted fewer manuscripts to the journal, rejection ratios did not differ for men and women. Efforts to increase the participation of women in the experimental analysis of behavior may best be directed toward recruitment and retention rather than some of the suggestions proposed by McSweeney and Swindell (1998), which could inadvertently create different standards for women's work.

  15. A multi-level analysis of the EU linking directive process: the controversial connection between EU and global climate policy

    Energy Technology Data Exchange (ETDEWEB)

    Flaam, Karoline Haegstad

    2007-10-15

    Despite initial scepticism in the EU towards the Kyoto Protocol's project mechanisms (the CDM and JI), the 'Linking Directive' was adopted in October 2004, connecting the EU emissions trading scheme with the project mechanisms. Not only was the Linking Directive settled remarkably quickly, the decision-making process also left a more liberal text, with fewer restrictions on the use of the project mechanisms, as compared to the initial directive proposal. This report examines possible explanations to this puzzle, evaluating whether Member State preferences, EU institutions or external influence from the climate regime best can contribute to understanding the process. On the basis of the analysis of written sources stemming from the decision-making process, as well as seven in-depth interviews, the report finds that Member State preferences were the main driver in the Linking Directive process. This gives support to the intergovernmentalist mantra, that Member States are the main decision-makers in the EU. It also challenges much recent research claiming that EU policy-making is increasingly being taken out of the hands of the nation-state and into supranational actors such as the Commission and the European Parliament. (author). 41 refs., figs., tabs

  16. A multi-level analysis of the EU linking directive process: the controversial connection between EU and global climate policy

    Energy Technology Data Exchange (ETDEWEB)

    Flaam, Karoline Haegstad

    2007-10-15

    Despite initial scepticism in the EU towards the Kyoto Protocol's project mechanisms (the CDM and JI), the 'Linking Directive' was adopted in October 2004, connecting the EU emissions trading scheme with the project mechanisms. Not only was the Linking Directive settled remarkably quickly, the decision-making process also left a more liberal text, with fewer restrictions on the use of the project mechanisms, as compared to the initial directive proposal. This report examines possible explanations to this puzzle, evaluating whether Member State preferences, EU institutions or external influence from the climate regime best can contribute to understanding the process. On the basis of the analysis of written sources stemming from the decision-making process, as well as seven in-depth interviews, the report finds that Member State preferences were the main driver in the Linking Directive process. This gives support to the intergovernmentalist mantra, that Member States are the main decision-makers in the EU. It also challenges much recent research claiming that EU policy-making is increasingly being taken out of the hands of the nation-state and into supranational actors such as the Commission and the European Parliament. (author). 41 refs., figs., tabs

  17. Photosensitized UVA-Induced Cross-Linking between Human DNA Repair and Replication Proteins and DNA Revealed by Proteomic Analysis

    Science.gov (United States)

    2016-01-01

    Long wavelength ultraviolet radiation (UVA, 320–400 nm) interacts with chromophores present in human cells to induce reactive oxygen species (ROS) that damage both DNA and proteins. ROS levels are amplified, and the damaging effects of UVA are exacerbated if the cells are irradiated in the presence of UVA photosensitizers such as 6-thioguanine (6-TG), a strong UVA chromophore that is extensively incorporated into the DNA of dividing cells, or the fluoroquinolone antibiotic ciprofloxacin. Both DNA-embedded 6-TG and ciprofloxacin combine synergistically with UVA to generate high levels of ROS. Importantly, the extensive protein damage induced by these photosensitizer+UVA combinations inhibits DNA repair. DNA is maintained in intimate contact with the proteins that effect its replication, transcription, and repair, and DNA–protein cross-links (DPCs) are a recognized reaction product of ROS. Cross-linking of DNA metabolizing proteins would compromise these processes by introducing physical blocks and by depleting active proteins. We describe a sensitive and statistically rigorous method to analyze DPCs in cultured human cells. Application of this proteomics-based analysis to cells treated with 6-TG+UVA and ciprofloxacin+UVA identified proteins involved in DNA repair, replication, and gene expression among those most vulnerable to cross-linking under oxidative conditions. PMID:27654267

  18. Linking Brief Functional Analysis to Intervention Design in General Education Settings

    Science.gov (United States)

    Ishuin, Tifanie

    2009-01-01

    This study focused on the utility and applicability of brief functional analysis in general education settings. The purpose of the study was to first identify the environmental variables maintaining noncompliance through a brief functional analysis, and then to design and implement a functionally equivalent intervention. The participant exhibited…

  19. Links between Bloom's Taxonomy and Gardener's Multiple Intelligences: The Issue of Textbook Analysis

    Science.gov (United States)

    Tabari, Mahmoud Abdi; Tabari, Iman Abdi

    2015-01-01

    The major thrust of this research was to investigate the cognitive aspect of the high school textbooks and interchange series, due to their extensive use, through content analysis based on Bloom's taxonomy and Gardner's Multiple Intelligences (MI). This study embraced two perspectives in a grid in order to broaden and deepen the analysis by…

  20. Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina

    DEFF Research Database (Denmark)

    Gallo, G.; Renzone, G.; Alduina, R.

    2010-01-01

    A differential proteomic analysis, based on 2-DE and MS procedures, was performed on Amycolatopsis balhimycina DSM5908, the actinomycete producing the vancomycin-like antibiotic balhimycin. A comparison of proteomic profiles before and during balhimycin production characterized differentially...... available over the World Wide Web as interactive web pages (http://www.unipa.it/ampuglia/Abal-proteome-maps). Functional clustering analysis revealed that differentially expressed proteins belong to functional groups involved in central carbon metabolism, amino acid metabolism and protein biosynthesis...... intermediates, were upregulated during antibiotic production. qRT-PCR analysis revealed that 8 out of 14 upregulated genes showed a positive correlation between changes at translational and transcriptional expression level. Furthermore, proteomic analysis of two nonproducing mutants, restricted to a sub...

  1. Financial analysis of experimental releases conducted at Glen Canyon Dam during water years 2006 through 2010.

    Energy Technology Data Exchange (ETDEWEB)

    Poch, L. A.; Veselka, T. D.; Palmer, C. S.; Loftin, S.; Osiek, B. (Decision and Information Sciences); (Western Area Power Administration, Colorado River Storage Project Management Center)

    2011-08-22

    Because of concerns about the impact that Glen Canyon Dam (GCD) operations were having on downstream ecosystems and endangered species, the Bureau of Reclamation (Reclamation) conducted an Environmental Impact Statement (EIS) on dam operations (DOE 1996). New operating rules and management goals for GCD that had been specified in the Record of Decision (ROD) (Reclamation 1996) were adopted in February 1997. In addition to issuing new operating criteria, the ROD mandated experimental releases for the purpose of conducting scientific studies. A report released in January 2011 examined the financial implications of the experimental flows that were conducted at the GCD from 1997 to 2005. This report continues the analysis and examines the financial implications of the experimental flows conducted at the GCD from 2006 to 2010. An experimental release may have either a positive or negative impact on the financial value of energy production. This study estimates the financial costs of experimental releases, identifies the main factors that contribute to these costs, and compares the interdependencies among these factors. An integrated set of tools was used to compute the financial impacts of the experimental releases by simulating the operation of the GCD under two scenarios, namely, (1) a baseline scenario that assumes both that operations comply with the ROD operating criteria and the experimental releases that actually took place during the study period, and (2) a 'without experiments' scenario that is identical to the baseline scenario of operations that comply with the GCD ROD, except it assumes that experimental releases did not occur. The Generation and Transmission Maximization (GTMax) model was the main simulation tool used to dispatch GCD and other hydropower plants that comprise the Salt Lake City Area Integrated Projects (SLCA/IP). Extensive data sets and historical information on SLCA/IP powerplant characteristics, hydrologic conditions, and Western

  2. Physical-layer security analysis of PSK quantum-noise randomized cipher in optically amplified links

    Science.gov (United States)

    Jiao, Haisong; Pu, Tao; Xiang, Peng; Zheng, Jilin; Fang, Tao; Zhu, Huatao

    2017-08-01

    The quantitative security of quantum-noise randomized cipher (QNRC) in optically amplified links is analyzed from the perspective of physical-layer advantage. Establishing the wire-tap channel models for both key and data, we derive the general expressions of secrecy capacities for the key against ciphertext-only attack and known-plaintext attack, and that for the data, which serve as the basic performance metrics. Further, the maximal achievable secrecy rate of the system is proposed, under which secrecy of both the key and data is guaranteed. Based on the same framework, the secrecy capacities of various cases can be assessed and compared. The results indicate perfect secrecy is potentially achievable for data transmission, and an elementary principle of setting proper number of photons and bases is given to ensure the maximal data secrecy capacity. But the key security is asymptotically perfect, which tends to be the main constraint of systemic maximal secrecy rate. Moreover, by adopting cascaded optical amplification, QNRC can realize long-haul transmission with secure rate up to Gb/s, which is orders of magnitude higher than the perfect secrecy rates of other encryption systems.

  3. Analysis of the solid waste management practices in Chinhoyi: bridging the missing link

    Directory of Open Access Journals (Sweden)

    Ishumael SANGO

    2010-12-01

    Full Text Available Over the years, there has been noticeable and steady mismatch between urban population growth and capacity for managing the corresponding increases in solid wastes. The local community is greatly concerned because it is aware of the clear link between poorly managed waste and the potential for the spread of diseases. This study was carried out to examine the solid waste management practices in Chinhoyi urban area and assess the impacts on the environment and human health. The study combined quantitative and qualitative data collected through fieldwork, questionnaires, interviews and document reviews. The population of Chinhoyi stands at about 60 000 generating more than 100 tons of waste per day. Results of the study include high percentage of uncollected waste, high levels of health and safety related problems such as lacerations, contusions, strain/sprains, and illness as well as noticeable deterioration of facilities and the environment. Issues affecting the effective management of waste are discussed. Recommendations based on the sustainable principle of integrated solid waste management are suggested. Sustainability requires the system to be environmentally effective, economically affordable, and socially acceptable.

  4. A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

    Energy Technology Data Exchange (ETDEWEB)

    Fawzi, Nicolas L. [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Fleissner, Mark R. [University of California, Jules Stein Eye Institute and Department of Chemistry and Biochemistry (United States); Anthis, Nicholas J. [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Kalai, Tamas; Hideg, Kalman [University of Pecs, Institute of Organic and Medicinal Chemistry (Hungary); Hubbell, Wayne L., E-mail: hubbellw@jsei.ucla.edu [University of California, Jules Stein Eye Institute and Department of Chemistry and Biochemistry (United States); Clore, G. Marius, E-mail: mariusc@mail.nih.gov [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States)

    2011-09-15

    The measurement of {sup 1}H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternative to these flexible labels for PRE studies. When introduced at solvent-exposed {alpha}-helical positions in two model proteins, calmodulin (CaM) and T4 lysozyme (T4L), EPR measurements show that the R1p side chain exhibits dramatically reduced internal motion compared to the commonly used R1 spin label (generated by reacting cysteine with the spin labeling compound often referred to as MTSL). Further, only a single nitroxide position is necessary to account for the PREs arising from CaM S17R1p, while an ensemble comprising multiple conformations is necessary for those observed for CaM S17R1. Together, these observations suggest that the nitroxide adopts a single, fixed position when R1p is placed at solvent-exposed {alpha}-helical positions, greatly simplifying the interpretation of PRE data by removing the need to account for the intrinsic flexibility of the spin label.

  5. A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

    International Nuclear Information System (INIS)

    Fawzi, Nicolas L.; Fleissner, Mark R.; Anthis, Nicholas J.; Kálai, Tamás; Hideg, Kálmán; Hubbell, Wayne L.; Clore, G. Marius

    2011-01-01

    The measurement of 1 H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternative to these flexible labels for PRE studies. When introduced at solvent-exposed α-helical positions in two model proteins, calmodulin (CaM) and T4 lysozyme (T4L), EPR measurements show that the R1p side chain exhibits dramatically reduced internal motion compared to the commonly used R1 spin label (generated by reacting cysteine with the spin labeling compound often referred to as MTSL). Further, only a single nitroxide position is necessary to account for the PREs arising from CaM S17R1p, while an ensemble comprising multiple conformations is necessary for those observed for CaM S17R1. Together, these observations suggest that the nitroxide adopts a single, fixed position when R1p is placed at solvent-exposed α-helical positions, greatly simplifying the interpretation of PRE data by removing the need to account for the intrinsic flexibility of the spin label.

  6. Electrification pathways for Kenya-linking spatial electrification analysis and medium to long term energy planning

    Science.gov (United States)

    Moksnes, Nandi; Korkovelos, Alexandros; Mentis, Dimitrios; Howells, Mark

    2017-09-01

    In September 2015 UN announced 17 Sustainable Development goals (SDG) from which goal number 7 envisions universal access to modern energy services for all by 2030. In Kenya only about 46% of the population currently has access to electricity. This paper analyses hypothetical scenarios, and selected implications, investigating pathways that would allow the country to reach its electrification targets by 2030. Two modelling tools were used for the purposes of this study, namely OnSSET and OSeMOSYS. The tools were soft-linked in order to capture both the spatial and temporal dynamics of their nature. Two electricity demand scenarios were developed representing low and high end user consumption goals respectively. Indicatively, results show that geothermal, coal, hydro and natural gas would consist the optimal energy mix for the centralized national grid. However, in the case of the low demand scenario a high penetration of stand-alone systems is evident in the country, reaching out to approximately 47% of the electrified population. Increasing end user consumption leads to a shift in the optimal technology mix, with higher penetration of mini-grid technologies and grid extension.

  7. Variable speed limit strategies analysis with link transmission model on urban expressway

    Science.gov (United States)

    Li, Shubin; Cao, Danni

    2018-02-01

    The variable speed limit (VSL) is a kind of active traffic management method. Most of the strategies are used in the expressway traffic flow control in order to ensure traffic safety. However, the urban expressway system is the main artery, carrying most traffic pressure. It has similar traffic characteristics with the expressways between cities. In this paper, the improved link transmission model (LTM) combined with VSL strategies is proposed, based on the urban expressway network. The model can simulate the movement of the vehicles and the shock wave, and well balance the relationship between the amount of calculation and accuracy. Furthermore, the optimal VSL strategy can be proposed based on the simulation method. It can provide management strategies for managers. Finally, a simple example is given to illustrate the model and method. The selected indexes are the average density, the average speed and the average flow on the traffic network in the simulation. The simulation results show that the proposed model and method are feasible. The VSL strategy can effectively alleviate traffic congestion in some cases, and greatly promote the efficiency of the transportation system.

  8. Implementation and analysis of trajectory schemes for informate: a serial link robot manipulator

    International Nuclear Information System (INIS)

    Rauf, A.; Ahmed, S.M.; Asif, M.; Ahmad, M.

    1997-01-01

    Trajectory planning schemes generally interpolate or approximate the desired path by a class of polynomial functions and generate a sequence of time based control set points for the control of the manipulator movement from certain initial configuration to final configuration. Schemes for trajectory generation can be implemented in Joint space and in Cartesian space. This paper describes Joint Space trajectory schemes and Cartesian Space trajectory schemes and their implementation for Infomate, a six degrees of freedom serial link robot manipulator. LSPBs and cubic Spline are chosen as interpolating functions of time for each type of schemes. Modules developed have been incorporated in an OLP system for Infomate. Trajectory planning Schemes discussed in this paper incorporate the constraints of velocities and accelerations of the actuators. comparison with respect to computation and motion time is presented for above mentioned trajectory schemes. Algorithms have been developed that enable the end effector to follow a straight line; other paths like circle, ellipse, etc. can be approximated by straight line segments. (author)

  9. Treating experimental data of inverse kinetic method by unitary linear regression analysis

    International Nuclear Information System (INIS)

    Zhao Yusen; Chen Xiaoliang

    2009-01-01

    The theory of treating experimental data of inverse kinetic method by unitary linear regression analysis was described. Not only the reactivity, but also the effective neutron source intensity could be calculated by this method. Computer code was compiled base on the inverse kinetic method and unitary linear regression analysis. The data of zero power facility BFS-1 in Russia were processed and the results were compared. The results show that the reactivity and the effective neutron source intensity can be obtained correctly by treating experimental data of inverse kinetic method using unitary linear regression analysis and the precision of reactivity measurement is improved. The central element efficiency can be calculated by using the reactivity. The result also shows that the effect to reactivity measurement caused by external neutron source should be considered when the reactor power is low and the intensity of external neutron source is strong. (authors)

  10. An experimental-numerical method for comparative analysis of joint prosthesis

    International Nuclear Information System (INIS)

    Claramunt, R.; Rincon, E.; Zubizarreta, V.; Ros, A.

    2001-01-01

    The difficulty that exists in the analysis of mechanical stresses in bones is high due to its complex mechanical and morphological characteristics. This complexity makes generalists modelling and conclusions derived from prototype tests very questionable. In this article a relatively simple comparative analysis systematic method that allow us to establish some behaviour differences in different kind of prosthesis is presented. The method, applicable in principle to any joint problem, is based on analysing perturbations produced in natural stress states of a bone after insertion of a joint prosthesis and combines numerical analysis using a 3-D finite element model and experimental studies based on photoelastic coating and electric extensometry. The experimental method is applied to compare two total hip prosthesis cement-free femoral stems of different philosophy. One anatomic of new generation, being of oblique setting over cancellous bone and the other madreporique of trochantero-diaphyseal support over cortical bone. (Author) 4 refs

  11. Preserving and maintaining vital Ecosystem Services: the importance of linking knowledge from Geosciences and social-ecological System analysis

    Science.gov (United States)

    Finger, David; Petursdottir, Thorunn

    2013-04-01

    Human kind has always been curios and motivated to understand and quantify environmental processes in order to predict and anticipate the evolution of vital ecosystem services. Even the very first civilizations used empirical correlations to predict outcomes of rains and subsequent harvest efficiencies. Along with the insights into the functioning of ecosystems, humans also became aware that their anthropogenic activities can have positive and negative impact on ecosystem services. In recent years, geosciences have brought forward new sophisticated observations and modeling tools, with the aim to improve predictions of ecological developments. At the same time, the added value of linking ecological factors to the surrounding social structure has received a growing acceptance among scientists. A social-ecological system approach brings in a holistic understanding of how these systems are inevitably interlinked and how their sustainability can be better maintained. We claim that the biggest challenge for geoscience in the coming decades will be to link these two disciplines in order to establish adequate strategies to preserve natural ecosystems and their services, parallel to their utilization. We will present various case studies from more than a decade of research, ranging from water quality in mountain lakes, climate change impacts on water availability and declining fishing yields in freshwaters and discuss how the studies outcomes could be given added value by interpreting them via social-ecological system analysis. For instance, sophisticated field investigations revealed that deep water mixing in lake Issyk-Kul, Kirgizstan, is intensively distributing pollutants in the entire lake. Although fishery is an important sector in the region, the local awareness of the importance of water quality is low. In Switzerland, strict water protection laws led to ologotrophication of alpine lakes, reducing fishing yields. While local fishermen argued that local fishery is

  12. Experimental design technique applied to the validation of an instrumental Neutron Activation Analysis procedure

    International Nuclear Information System (INIS)

    Santos, Uanda Paula de M. dos; Moreira, Edson Gonçalves

    2017-01-01

    In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2 k experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 2 3 and the 2 4 , depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN /CNEN-SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions. (author)

  13. Experimental design technique applied to the validation of an instrumental Neutron Activation Analysis procedure

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Uanda Paula de M. dos; Moreira, Edson Gonçalves, E-mail: uandapaula@gmail.com, E-mail: emoreira@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2{sup k} experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 2{sup 3} and the 2{sup 4}, depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN /CNEN-SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions. (author)

  14. Development of a thermal-hydraulic code for reflood analysis in a PWR experimental loop

    International Nuclear Information System (INIS)

    Alves, Sabrina P.; Mesquita, Amir Z.; Rezende, Hugo C.; Palma, Daniel A.P.

    2017-01-01

    A process of fundamental importance in the event of Loss of Coolant Accident (LOCA) in Pressurized Water nuclear Reactors (PWR) is the reflood of the core or rewetting of nuclear fuels. The Nuclear Technology Development Center (CDTN) has been developing since the 70’s programs to allow Brazil to become independent in the field of reactor safety analysis. To that end, in the 80’s was designed, assembled and commissioned one Rewetting Test Facility (ITR in Portuguese). This facility aims to investigate the phenomena involved in the thermal hydraulic reflood phase of a Loss of Coolant Accident in a PWR nuclear reactor. This work aim is the analysis of physical and mathematical models governing the rewetting phenomenon, and the development a thermo-hydraulic simulation code of a representative experimental circuit of the PWR reactors core cooling channels. It was possible to elaborate and develop a code called REWET. The results obtained with REWET were compared with the experimental results of the ITR, and with the results of the Hydroflut code, that was the old program previously used. An analysis was made of the evolution of the wall temperature of the test section as well as the evolution of the front for two typical tests using the two codes calculation, and experimental results. The result simulated by REWET code for the rewetting time also came closer to the experimental results more than those calculated by Hydroflut code. (author)

  15. Development of a thermal-hydraulic code for reflood analysis in a PWR experimental loop

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Sabrina P.; Mesquita, Amir Z.; Rezende, Hugo C., E-mail: sabrinapral@gmail.com, E-mail: amir@cdtn.brm, E-mail: hcr@cdtn.br, E-mail: hcr@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Palma, Daniel A.P., E-mail: dapalma@cnen.gov.br [Comissão Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    A process of fundamental importance in the event of Loss of Coolant Accident (LOCA) in Pressurized Water nuclear Reactors (PWR) is the reflood of the core or rewetting of nuclear fuels. The Nuclear Technology Development Center (CDTN) has been developing since the 70’s programs to allow Brazil to become independent in the field of reactor safety analysis. To that end, in the 80’s was designed, assembled and commissioned one Rewetting Test Facility (ITR in Portuguese). This facility aims to investigate the phenomena involved in the thermal hydraulic reflood phase of a Loss of Coolant Accident in a PWR nuclear reactor. This work aim is the analysis of physical and mathematical models governing the rewetting phenomenon, and the development a thermo-hydraulic simulation code of a representative experimental circuit of the PWR reactors core cooling channels. It was possible to elaborate and develop a code called REWET. The results obtained with REWET were compared with the experimental results of the ITR, and with the results of the Hydroflut code, that was the old program previously used. An analysis was made of the evolution of the wall temperature of the test section as well as the evolution of the front for two typical tests using the two codes calculation, and experimental results. The result simulated by REWET code for the rewetting time also came closer to the experimental results more than those calculated by Hydroflut code. (author)

  16. Experimental 2.5 Gbit/s QPSK WDM coherent phase modulated radio-over-fibre link with digital demodulation by a K-means algorithm

    DEFF Research Database (Denmark)

    Guerrero Gonzalez, Neil; Caballero Jambrina, Antonio; Amaya Fernández, Ferney Orlando

    2009-01-01

    Highest reported bit rate of 2.5 Gbit/s for optically phase modulated radio-over-fibre link employing coherent detection is demonstrated. Demodulation of 3·2.5 Gbit/s QPSK modulated WDM channels, is achieved after 79km of transmission through deployed fiber....

  17. Analysis of fourth-grade flat machines with movable close-cycle formed by the rods and two complex links

    Directory of Open Access Journals (Sweden)

    S.О. Koshel

    2016-09-01

    Full Text Available Complex multielement mechanisms are increasingly used in the technical equipment of consumer industry. The lack of a universal method of kinematic research of these mechanisms asserts the relevance of work on the kinematic analysis of multielement mechanisms. Aim: The aim of this research is to develop an algorithm kinetic research of velocities of the points that coincide with geometric centers kinematic pairs of structure group of the 4th class and 3rd order with movable close-cycle formed by connecting rod and two complex links. Materials and Methods: The graphic-analytical method of a kinematic research will be used to achieve the goals of research. Development of an algorithm is based on provisions of the theory of mechanisms and engines about property of high classes mechanisms to change its class depending on another possible initial mechanism chosen conditionally which comes to structure of the conducted structural groups of the mechanism links and provisions of theoretical mechanics relatively to instantaneous center of speeds. Results: Velocity vectors of points of Assur group links of the 4th class and 3rd order of the composite flat mechanism are determined by a graphic-analytical method, where the initial mechanism speeds that led to decrease of a class of the mechanism and allowed to investigate it. Unlike the known erroneous statements method which is applied to research the structural groups of the 3rd class, the offered algorithm of the kinematic analysis allows to investigate mechanisms of the 4th class without need to rebuild the plan which was constructed in a uncertain scale, with the subsequent calculation of the real scale parameter of provided plotting of a graph.

  18. Experimental and FE Analysis of Exterior Plastic Components of Cars under Static and Dynamic Loading Conditions

    OpenAIRE

    Faghihi, Hassan

    2011-01-01

    This thesis is composed by an experimental part and numerical part, aimed at contributing to a better knowledge of the behavior of plastic parts under different loading conditions. The study is intended to validate a FE model for simulating exterior plastic components of car especially the A-decor and plastic clips in the context of thermal and static load analysis. From the comparison of numerical and experimental results in the terms of thermal and static deformation of the A-decor, it is c...

  19. 1988 Progress report of the EDF department for the analysis of experimental data and measurements

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The 1988 activity report of the department for the analysis of experimental data and measurements (Department of Retour d'Experience Mesures-Essais, of EDF, France), is presented. The mission of the department is to collect and investigate data from the nuclear power plant operations. The investigations started before 1988, were carried on in 1988. The department main activities are: technology and information transfer from experimental activities, the construction of a standard data acquisition and processing system, the actions involving the N4 turbine, and the modelling and construction of new non-destructive methods of control. The most important facts and activities carried out in 1988 are presented [fr

  20. An experimental and theoretical analysis of void fraction dynamics in a boiling channel

    International Nuclear Information System (INIS)

    Romberg, T.M.

    1977-01-01

    This paper describes an experimental and theoretical investigation of the void fraction dynamics at the exit of a test boiling channel which is operated near the 'instability threshold power' (the power level at which coolant flow instabilities occur). Dynamic measurements of the perturbations in channel inlet flow-rate, power input and exit void fraction are analysed using multivariate spectral analysis. The resulting experimental cross-spectral density functions between flow-rate/exit void fraction and power input/exit void fraction agree favourably with those calculated by a linearised hydrodynamic model in the frequency domain. (Author)

  1. 6. GESA symposium on experimental stress analysis, May 6 and 7, 1982 Stuttgart

    Energy Technology Data Exchange (ETDEWEB)

    1982-04-01

    Under the scientific chairmanship of Dr. H. Wolf, KWU Muehlheim/Ruhr, the 6th Symposium of the Gemeinschaft Experimentelle Spannungsanalyse (GESA = Experimental Stress Analysis Association) takes place in the Schwabenlandhalle at Fellbach near Stuttgart. The meeting will be organized by VDI/VDE-Gesellschaft Mess- und Regelungstechnik (GMR = VDI/VDE Society for Instrumentation and Control Engineering) located at Duesseldorf. It will be associated with an exposition of firms working in the field of experimental mechanics and presenting among other things developments in the fields of measuring transmitters, data acquisition and processing.

  2. 6. GESA symposium on experimental stress analysis, May 6 and 7, 1982 Stuttgart

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    Under the scientific chairmanship of Dr. H. Wolf, KWU Muehlheim/Ruhr the 6th Symposium of the Gemeinschaft Experimentelle Spannungsanalyse (GESA = Experimental Stress Analysis Association) takes place in the Schwabenlandhalle at Fellbach near Stuttgart. The meeting will be organized by VDI/VDE-Gesellschaft Mess- und Regelungstechnik (GMR = VDI/VDE Society for Instrumentation and Control Engineering) located at Duesseldorf. It will be associated with an exposition of firms working in the field of experimental mechanics and presenting among other things developments in the fields of measuring transmitters, data acquisition and processing. (orig./RW) [de

  3. Density functional theoretical analysis with experimental, invitro bioactivity and molecular docking investigations on the pesticide Albendazole

    Science.gov (United States)

    Divya, P.; Bena Jothy, V.

    2018-03-01

    Optimized structural parameters of Albendazole and corresponding vibrational assignments have been studied using infrared and Raman spectroscopy combined with quantum-chemical calculations. Results of these spectroscopic studies have been successfully compared against obtained experimental data. Difference between experimental and calculated CH3 group wavenumbers was blue-shifted by 58 cm-1 and 43 cm-1, respectively due to electronic effects. In NBO analysis the increase in energies and the shortening of Csbnd N and Cdbnd O bonds gives clear evidence that the resonance of the benzimidazole ring is increased by the groups. Best binding score of Albendazole was obtained with protein 4NQ6 (-5.58 kcal/mol).

  4. Exploring the genetics underlying autoimmune diseases with network analysis and link prediction

    KAUST Repository

    Alanis Lobato, Gregorio; Cannistraci, Carlo; Ravasi, Timothy

    2014-01-01

    Ever since the first Genome Wide Association Study (GWAS) was carried out we have seen an important number of discoveries of biological and clinical relevance. However, there are some scientists that consider that these research outcomes and their utility are far from what was expected from this experimental design. We instead believe that the thousands of genetic variants associated with complex disorders by means of GWASs are an extremely valuable source of information that needs to be mined in a different way. Based on this philosophy, we followed a holistic perspective to analyze GWAS data and explored the structural properties of the network representation of one of these datasets with the aim to advance our understanding of the genetic intricacies underlying autoimmune human diseases. The simplicity, computational efficiency and precision of the tools proposed in this paper represent a new means to address GWAS data and contribute to the better exploitation of these rich sources of information. © 2014 IEEE.

  5. Exploring the genetics underlying autoimmune diseases with network analysis and link prediction

    KAUST Repository

    Alanis Lobato, Gregorio

    2014-02-01

    Ever since the first Genome Wide Association Study (GWAS) was carried out we have seen an important number of discoveries of biological and clinical relevance. However, there are some scientists that consider that these research outcomes and their utility are far from what was expected from this experimental design. We instead believe that the thousands of genetic variants associated with complex disorders by means of GWASs are an extremely valuable source of information that needs to be mined in a different way. Based on this philosophy, we followed a holistic perspective to analyze GWAS data and explored the structural properties of the network representation of one of these datasets with the aim to advance our understanding of the genetic intricacies underlying autoimmune human diseases. The simplicity, computational efficiency and precision of the tools proposed in this paper represent a new means to address GWAS data and contribute to the better exploitation of these rich sources of information. © 2014 IEEE.

  6. Exergo-Economic Analysis of an Experimental Aircraft Turboprop Engine Under Low Torque Condition

    Science.gov (United States)

    Atilgan, Ramazan; Turan, Onder; Aydin, Hakan

    Exergo-economic analysis is an unique combination of exergy analysis and cost analysis conducted at the component level. In exergo-economic analysis, cost of each exergy stream is determined. Inlet and outlet exergy streams of the each component are associated to a monetary cost. This is essential to detect cost-ineffective processes and identify technical options which could improve the cost effectiveness of the overall energy system. In this study, exergo-economic analysis is applied to an aircraft turboprop engine. Analysis is based on experimental values at low torque condition (240 N m). Main components of investigated turboprop engine are the compressor, the combustor, the gas generator turbine, the free power turbine and the exhaust. Cost balance equations have been formed for all components individually and exergo-economic parameters including cost rates and unit exergy costs have been calculated for each component.

  7. Experimental and numerical analysis of semi-destructive device for in situ assessment of wood properties in compression parallel to grain

    Czech Academy of Sciences Publication Activity Database

    Kloiber, Michal; Kunecký, Jiří; Drdácký, Miloš; Tippner, J.; Sebera, V.

    2017-01-01

    Roč. 51, č. 2 (2017), s. 345-356 ISSN 0043-7719 R&D Projects: GA MK(CZ) DG16P02M026; GA MŠk(CZ) LO1219 Keywords : finite element method * experimental and numerical analysis * historical construction * mechanical properties of wood Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Paper and wood Impact factor: 1.509, year: 2016 http://link.springer.com/article/10.1007%2Fs00226-016-0881-6

  8. Links between Bloom's Taxonomy and Gardener's Multiple Intelligences: The issue of Textbook Analysis

    Directory of Open Access Journals (Sweden)

    Mahmoud Abdi Tabari

    2015-02-01

    Full Text Available The major thrust of this research was to investigate the cognitive aspect of the high school textbooks and interchange series, due to their extensive use, through content analysis based on Bloom's taxonomy and Gardner's Multiple Intelligences (MI. This study embraced two perspectives in a grid in order to broaden and deepen the analysis by determining the numbers and the types of intelligences with respect to their learning objectives tapped in the textbooks and comparing them. Through codification of Bloom’s learning objectives and Gardner's MI, the results showed that there was a significant difference between the numbers of intelligences with respect to their learning objectives in the textbooks. However, the interchange series enjoyed a large number of the spatial and the interpersonal intelligences across eight levels of learning objectives, whereas they had the least number of the intrapersonal, the musical, and the bodily-kinesthetic intelligences across knowledge understanding and application levels. Keywords: learning objectives, multiple intelligences, textbook analysis

  9. Analysis of Anatomic and Functional Measures in X-Linked Retinoschisis

    Science.gov (United States)

    Cukras, Catherine A.; Huryn, Laryssa A.; Jeffrey, Brett P.; Turriff, Amy; Sieving, Paul A.

    2018-01-01

    Purpose To examine the symmetry of structural and functional parameters between eyes in patients with X-linked retinoschisis (XLRS), as well as changes in visual acuity and electrophysiology over time. Methods This is a single-center observational study of 120 males with XLRS who were evaluated at the National Eye Institute. Examinations included best-corrected visual acuity for all participants, as well as ERG recording and optical coherence tomography (OCT) on a subset of participants. Statistical analyses were performed using nonparametric Spearman correlations and linear regression. Results Our analyses demonstrated a statistically significant correlation of structural and functional measures between the two eyes of XLRS patients for all parameters. OCT central macular thickness (n = 78; Spearman r = 0.83, P < 0.0001) and ERG b/a ratio (n = 78; Spearman r = 0.82, P < 0.0001) were the most strongly correlated between a participant's eyes, whereas visual acuity was less strongly correlated (n = 120; Spearman r = 0.47, P < 0.0001). Stability of visual acuity was observed with an average change of less than one letter (n = 74; OD −0.66 and OS −0.70 letters) in a mean follow-up time of 6.8 years. There was no statistically significant change in the ERG b/a ratio within eyes over time. Conclusions Although a broad spectrum of clinical phenotypes is observed across individuals with XLRS, our study demonstrates a significant correlation of structural and functional findings between the two eyes and stability of measures of acuity and ERG parameters over time. These results highlight the utility of the fellow eye as a useful reference for monocular interventional trials.

  10. Identification of physicians providing comprehensive primary care in Ontario: a retrospective analysis using linked administrative data.

    Science.gov (United States)

    Schultz, Susan E; Glazier, Richard H

    2017-12-19

    Given the changing landscape of primary care, there may be fewer primary care physicians available to provide a broad range of services to patients of all age groups and health conditions. We sought to identify physicians with comprehensive primary care practices in Ontario using administrative data, investigating how many and what proportion of primary care physicians provided comprehensive primary care and how this changed over time. We identified the pool of active primary care physicians in linked population-based databases for Ontario from 1992/93 to 2014/15. After excluding those who saw patients fewer than 44 days per year, we identified physicians as providing comprehensive care if more than half of their services were for core primary care and if these services fell into at least 7 of 22 activity areas. Physicians with 50% or less of their services for core primary care but with more than 50% in a single location or type of service were identified as being in focused practice. In 2014/15, there were 12 891 physicians in the primary care pool: 1254 (9.7%) worked fewer than 44 days per year, 1619 (12.6%) were in focused practice, and 1009 (7.8%) could not be classified. The proportion in comprehensive practice ranged from 67.5% to 74.9% between 1992/93 and 2014/15, with a peak in 2002/03 and relative stability from 2009/10 to 2014/15. Over this period, there was an increase of 8.8% in population per comprehensive primary care physician. We found that just over two-thirds of primary care physicians provided comprehensive care in 2014/15, which indicates that traditional estimates of the primary care physician workforce may be too high. Although implementation will vary by setting and available data, this approach is likely applicable elsewhere. Copyright 2017, Joule Inc. or its licensors.

  11. A Simulation Study of Threats to Validity in Quasi-Experimental Designs: Interrelationship between Design, Measurement, and Analysis.

    Science.gov (United States)

    Holgado-Tello, Fco P; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana; Pérez-Gil, José A

    2016-01-01

    The Campbellian tradition provides a conceptual framework to assess threats to validity. On the other hand, different models of causal analysis have been developed to control estimation biases in different research designs. However, the link between design features, measurement issues, and concrete impact estimation analyses is weak. In order to provide an empirical solution to this problem, we use Structural Equation Modeling (SEM) as a first approximation to operationalize the analytical implications of threats to validity in quasi-experimental designs. Based on the analogies established between the Classical Test Theory (CTT) and causal analysis, we describe an empirical study based on SEM in which range restriction and statistical power have been simulated in two different models: (1) A multistate model in the control condition (pre-test); and (2) A single-trait-multistate model in the control condition (post-test), adding a new mediator latent exogenous (independent) variable that represents a threat to validity. Results show, empirically, how the differences between both the models could be partially or totally attributed to these threats. Therefore, SEM provides a useful tool to analyze the influence of potential threats to validity.

  12. An innovative experimental sequence on electromagnetic induction and eddy currents based on video analysis and cheap data acquisition

    International Nuclear Information System (INIS)

    Bonanno, A; Sapia, P; Bozzo, G

    2017-01-01

    In this work, we present a coherent sequence of experiments on electromagnetic (EM) induction and eddy currents, appropriate for university undergraduate students, based on a magnet falling through a drilled aluminum disk. The sequence, leveraging on the didactical interplay between the EM and mechanical aspects of the experiments, allows us to exploit the students’ awareness of mechanics to elicit their comprehension of EM phenomena. The proposed experiments feature two kinds of measurements: (i) kinematic measurements (performed by means of high-speed video analysis) give information on the system’s kinematics and, via appropriate numerical data processing, allow us to get dynamic information, in particular on energy dissipation; (ii) induced electromagnetic field (EMF) measurements (by using a homemade multi-coil sensor connected to a cheap data acquisition system) allow us to quantitatively determine the inductive effects of the moving magnet on its neighborhood. The comparison between experimental results and the predictions from an appropriate theoretical model (of the dissipative coupling between the moving magnet and the conducting disk) offers many educational hints on relevant topics related to EM induction, such as Maxwell’s displacement current, magnetic field flux variation, and the conceptual link between induced EMF and induced currents. Moreover, the didactical activity gives students the opportunity to be trained in video analysis, data acquisition and numerical data processing. (paper)

  13. Aujeszky's disease in red fox (Vulpes vulpes): phylogenetic analysis unravels an unexpected epidemiologic link.

    Science.gov (United States)

    Caruso, Claudio; Dondo, Alessandro; Cerutti, Francesco; Masoero, Loretta; Rosamilia, Alfonso; Zoppi, Simona; D'Errico, Valeria; Grattarola, Carla; Acutis, Pier Luigi; Peletto, Simone

    2014-07-01

    We describe Aujeszky's disease in a female of red fox (Vulpes vulpes). Although wild boar (Sus scrofa) would be the expected source of infection, phylogenetic analysis suggested a domestic rather than a wild source of virus, underscoring the importance of biosecurity measures in pig farms to prevent contact with wild animals.

  14. A Social Network Analysis of the Financial Links Backing Health and Fitness Apps.

    Science.gov (United States)

    Grundy, Quinn; Held, Fabian; Bero, Lisa

    2017-11-01

    To identify the major stakeholders in mobile health app development and to describe their financial relationships using social network analysis. We conducted a structured content analysis of a purposive sample of prominent health and fitness apps available in November 2015 in the United States, Canada, and Australia. We conducted a social network analysis of apps' developers, investors, other funding sources, and content advisors to describe the financial relationships underpinning health app development. Prominent health and fitness apps are largely developed by private companies based in North America, with an average of 4.7 (SD = 5.5) financial relations, including founders, external investors, acquiring companies, and commercial partnerships. Network analysis revealed a core of 41 sampled apps connected to 415 other entities by 466 financial relations. This core largely comprised apps published by major technology, pharmaceutical, and fashion corporations. About one third of apps named advisors, many of whom had commercial affiliations. Public health needs to extend its scrutiny and advocacy beyond the health messages contained within apps to understanding commercial influences on health and, when necessary, challenging them.

  15. Satellite tracking and stable isotope analysis link wintering and feeding grounds of North Atlantic baleen whales

    NARCIS (Netherlands)

    e Silva, Monica Almeida; Prieto, Rui; Gauffier, Pauline; Palsboll, Per; Bérubé, Martine; Colaco, Ana

    2017-01-01

    Knowledge of the distribution of baleen whales throughout their annual cycle is critical for understanding their ecology, life history and behavior, and for their effective conservation. We combined analysis of stable isotopes (δ15N and δ13C) and satellite tracking data of blue (Balaenoptera

  16. Supply Chain Visibility with Linked Open Data for Supply Chain Risk Analysis

    NARCIS (Netherlands)

    Hofman, W.J.

    2011-01-01

    Current customs applications are declaration based to support the various customs procedures based on (inter)national laws and regulations. To be able to perform a proper supply chain risk analysis, customs requires to have all data in supply chains. The current declaration procedures are not

  17. Constraint Network Analysis (CNA): a Python software package for efficiently linking biomacromolecular structure, flexibility, (thermo-)stability, and function.

    Science.gov (United States)

    Pfleger, Christopher; Rathi, Prakash Chandra; Klein, Doris L; Radestock, Sebastian; Gohlke, Holger

    2013-04-22

    For deriving maximal advantage from information on biomacromolecular flexibility and rigidity, results from rigidity analyses must be linked to biologically relevant characteristics of a structure. Here, we describe the Python-based software package Constraint Network Analysis (CNA) developed for this task. CNA functions as a front- and backend to the graph-based rigidity analysis software FIRST. CNA goes beyond the mere identification of flexible and rigid regions in a biomacromolecule in that it (I) provides a refined modeling of thermal unfolding simulations that also considers the temperature-dependence of hydrophobic tethers, (II) allows performing rigidity analyses on ensembles of network topologies, either generated from structural ensembles or by using the concept of fuzzy noncovalent constraints, and (III) computes a set of global and local indices for quantifying biomacromolecular stability. This leads to more robust results from rigidity analyses and extends the application domain of rigidity analyses in that phase transition points ("melting points") and unfolding nuclei ("structural weak spots") are determined automatically. Furthermore, CNA robustly handles small-molecule ligands in general. Such advancements are important for applying rigidity analysis to data-driven protein engineering and for estimating the influence of ligand molecules on biomacromolecular stability. CNA maintains the efficiency of FIRST such that the analysis of a single protein structure takes a few seconds for systems of several hundred residues on a single core. These features make CNA an interesting tool for linking biomacromolecular structure, flexibility, (thermo-)stability, and function. CNA is available from http://cpclab.uni-duesseldorf.de/software for nonprofit organizations.

  18. Removal of Cr(III ions from salt solution by nanofiltration: experimental and modelling analysis

    Directory of Open Access Journals (Sweden)

    Kowalik-Klimczak Anna

    2016-09-01

    Full Text Available The aim of this study was experimental and modelling analysis of the nanofiltration process used for the removal of chromium(III ions from salt solution characterized by low pH. The experimental results were interpreted with Donnan and Steric Partitioning Pore (DSP model based on the extended Nernst-Planck equation. In this model, one of the main parameters, describing retention of ions by the membrane, is pore dielectric constant. In this work, it was identified for various process pressures and feed compositions. The obtained results showed the satisfactory agreement between the experimental and modelling data. It means that the DSP model may be helpful for the monitoring of nanofiltration process applied for treatment of chromium tannery wastewater.

  19. Experimental and computational study on molecular structure and vibrational analysis of an antihyperglycemic biomolecule: Gliclazide

    Science.gov (United States)

    Karakaya, Mustafa; Kürekçi, Mehmet; Eskiyurt, Buse; Sert, Yusuf; Çırak, Çağrı

    2015-01-01

    In present study, the experimental and theoretical harmonic vibrational frequencies of gliclazide molecule have been investigated. The experimental FT-IR (400-4000 cm-1) and Laser-Raman spectra (100-4000 cm-1) of the molecule in the solid phase were recorded. Theoretical vibrational frequencies and geometric parameters (bond lengths and bond angles) have been calculated using ab initio Hartree Fock (HF), density functional theory (B3LYP hybrid function) methods with 6-311++G(d,p) and 6-31G(d,p) basis sets by Gaussian 09W program. The assignments of the vibrational frequencies were performed by potential energy distribution (PED) analysis by using VEDA 4 program. Theoretical optimized geometric parameters and vibrational frequencies have been compared with the corresponding experimental data, and they have been shown to be in a good agreement with each other. Also, the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energies have been found.

  20. Stability and spring constant investigation for micromachined inductive suspensions: theoretical analysis vs. experimental results

    International Nuclear Information System (INIS)

    Poletkin, K; Lu, Z; Wallrabe, U; Badilita, V; Den Hartogh, B

    2014-01-01

    We present a linear analytical model coupled with experimental analysis to discuss stability of a levitated proof mass (PM) in a micromachined inductive suspension (MIS), which has been previously introduced and characterized. The model is a function of the MIS geometry, describes the dynamics of a levitated disk-shaped PM near the equilibrium point, and predicts conditions for stable levitation. The experimental setup directly measures the lateral component of the Lorentz force, which has a stabilization role in the MIS structure, as well as the vertical levitation force. The experimental setup is further used to derive mechanical parameters such as stiffness values relative to lateral, vertical and angular displacements, proven to be in excellent agreement with the values predicted by the analytical model

  1. Analysis of polymer/oxide interfaces under ambient conditions - An experimental perspective

    Science.gov (United States)

    González-Orive, A.; Giner, I.; de los Arcos, T.; Keller, A.; Grundmeier, G.

    2018-06-01

    In many different hybrid materials and materials composites polymers adhere to bulk oxides or oxide covered metal. The formed polymer/oxide interfaces are of crucial importance for the functionality and durability of such complex materials. Especially, under humid and corrosive conditions such interfaces tend to degrade due to permeability of polymers for water, the high adsorption energy of water on oxide surfaces and even corrosion processes of the metal. Different experimental studies considered such interfaces ranging from spectroscopy to electrochemical analysis. However, it is still a challenge to understand the complex interaction especially under non-ideal ambient conditions. The perspective article presents an overview on the existing experimental approaches and considers most recent experimental developments with regard to their potential applications in the area of polymer/oxide interfaces in the future.

  2. Linking the Lusi mud eruption dynamics with regional and global seismic activity: a statistical analysis.

    Science.gov (United States)

    Collignon, Marine; Hammer, Øyvind; Fallahi, Mohammad J.; Lupi, Matteo; Schmid, Daniel W.; Alwi, Husein; Hadi, Soffian; Mazzini, Adriano

    2017-04-01

    The 29th May 2006, gas water and mud breccia started to erupt at several localities along the Watukosek fault system in the Sidoarjo Regency in East Java Indonesia. The most prominent eruption site, named Lusi, is still active and the emitted material now covers a surface of nearly 7 km2, resulting in the displacement of 60.000 people (up to date). Due to its social and economic impacts, as well as its spectacular dimensions, the Lusi eruption still attracts the attention of international media and scientists. In the framework of the Lusi Lab project (ERC grant n° 308126), many efforts were made to develop a quasi-constant monitoring of the site and the regional areas. Several studies attempted to predict the flow rate evolution or ground deformation, resulting in either overestimating or underestimating the longevity of the eruption. Models have failed because Lusi is not a mud volcano but a sedimentary hosted hydrothermal system that became apparent after the M6.3 Yogyakarta earthquake. Another reason is because such models usually assume that the flow will decrease pacing the overpressure reduction during the deflation of the chamber. These models typically consider a closed system with a unique chamber that is not being recharged. Overall the flow rate has decreased over the past ten years, although it has been largely fluctuating with monthly periods of higher mud breccia discharge. Monitoring of the eruption has revealed that numerous anomalous events are temporally linked to punctual events such as earthquakes or volcanic eruptions. Nevertheless, the quantification of these events has never been investigated in details. In this study, we present a compilation of anomalous events observed at the Lusi site during the last 10 years. Using Monte Carlo simulations, we then statistically compare the displacement, recorded at different seismic stations around Lusi, with the regional and global earthquakes catalogue to test the probability that an earthquake

  3. Socioeconomic status as an effect modifier of alcohol consumption and harm: analysis of linked cohort data.

    Science.gov (United States)

    Katikireddi, Srinivasa Vittal; Whitley, Elise; Lewsey, Jim; Gray, Linsay; Leyland, Alastair H

    2017-06-01

    Alcohol-related mortality and morbidity are high in socioeconomically disadvantaged populations compared with individuals from advantaged areas. It is unclear if this increased harm reflects differences in alcohol consumption between these socioeconomic groups, reverse causation (ie, downward social selection for high-risk drinkers), or a greater risk of harm in individuals of low socioeconomic status compared with those of higher status after similar consumption. We aimed to investigate whether the harmful effects of alcohol differ by socioeconomic status, accounting for alcohol consumption and other health-related factors. The Scottish Health Surveys are record-linked cross-sectional surveys representative of the adult population of Scotland. We obtained baseline demographics and data for alcohol consumption (units per week and binge drinking) from Scottish Health Surveys done in 1995, 1998, 2003, 2008, 2009, 2010, 2011, and 2012. We matched these data to records for deaths, admissions, and prescriptions. The primary outcome was alcohol-attributable admission or death. The relation between alcohol-attributable harm and socioeconomic status was investigated for four measures (education level, social class, household income, and area-based deprivation) using Cox proportional hazards models. The potential for alcohol consumption and other risk factors (including smoking and body-mass index [BMI]) mediating social patterning was explored in separate regression models. Reverse causation was tested by comparing change in area deprivation over time. 50 236 participants (21 777 men and 28 459 women) were included in the analytical sample, with 429 986 person-years of follow-up. Low socioeconomic status was associated consistently with strikingly raised alcohol-attributable harms, including after adjustment for weekly consumption, binge drinking, BMI, and smoking. Evidence was noted of effect modification; for example, relative to light drinkers living in

  4. Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells

    International Nuclear Information System (INIS)

    Jones, Meredith B.; Tomiya, Noboru; Betenbaugh, Michael J.; Krag, Sharon S.

    2010-01-01

    Glycosylation-deficient Chinese Hamster Ovary (CHO) cell lines can be used to expand our understanding of N-glycosylation pathways and to study Congenital Disorders of Glycosylation, diseases caused by defects in the synthesis of N-glycans. The mammalian N-glycosylation pathway involves the step-wise assembly of sugars onto a dolichol phosphate (P-Dol) carrier, forming a lipid-linked oligosaccharide (LLO), followed by the transfer of the completed oligosaccharide onto the protein of interest. In order to better understand how deficiencies in this pathway affect the availability of the completed LLO donor for use in N-glycosylation, we used a non-radioactive, HPLC-based assay to examine the intermediates in the LLO synthesis pathway for CHO-K1 cells and for three different glycosylation-deficient CHO cell lines. B4-2-1 cells, which have a mutation in the dolichol phosphate-mannose synthase (DPM2) gene, accumulated LLO with the structure Man 5 GlcNAc 2 -P-P-Dol, while MI8-5 cells, which lack glucosyltransferase I (ALG6) activity, accumulated Man 9 GlcNAc 2 -P-P-Dol. CHO-K1 and MI5-4 cells both produced primarily the complete LLO, Glc 3 Man 9 GlcNAc 2 -P-P-Dol, though the relative quantity was lower in MI5-4. MI5-4 cells have reduced hexokinase activity which could affect the availability of many of the substrates required for LLO synthesis and, consequently, impair production of the final LLO donor. Increasing hexokinase activity by overexpressing hexokinase II in MI5-4 caused a decrease in the relative quantities of the incomplete LLO intermediates from Man 5 GlcNAc 2 -PP-Dol through Glc 1 Man 9 GlcNAc 2 -PP-Dol, and an increase in the relative quantity of the final LLO donor, Glc 3 Man 9 GlcNAc 2 -P-P-Dol. This study suggests that metabolic engineering may be a useful strategy for improving LLO availability for use in N-glycosylation.

  5. Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Meredith B., E-mail: mbauman7@jhu.edu [Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Maryland Hall 221, Baltimore, MD 21218 (United States); Tomiya, Noboru, E-mail: ntomiya1@jhu.edu [Department of Biology, Johns Hopkins University, 3400 North Charles Street, Mudd Hall 104A, Baltimore, MD 21218 (United States); Betenbaugh, Michael J., E-mail: beten@jhu.edu [Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Maryland Hall 221, Baltimore, MD 21218 (United States); Krag, Sharon S., E-mail: skrag@jhsph.edu [Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205 (United States)

    2010-04-23

    Glycosylation-deficient Chinese Hamster Ovary (CHO) cell lines can be used to expand our understanding of N-glycosylation pathways and to study Congenital Disorders of Glycosylation, diseases caused by defects in the synthesis of N-glycans. The mammalian N-glycosylation pathway involves the step-wise assembly of sugars onto a dolichol phosphate (P-Dol) carrier, forming a lipid-linked oligosaccharide (LLO), followed by the transfer of the completed oligosaccharide onto the protein of interest. In order to better understand how deficiencies in this pathway affect the availability of the completed LLO donor for use in N-glycosylation, we used a non-radioactive, HPLC-based assay to examine the intermediates in the LLO synthesis pathway for CHO-K1 cells and for three different glycosylation-deficient CHO cell lines. B4-2-1 cells, which have a mutation in the dolichol phosphate-mannose synthase (DPM2) gene, accumulated LLO with the structure Man{sub 5}GlcNAc{sub 2}-P-P-Dol, while MI8-5 cells, which lack glucosyltransferase I (ALG6) activity, accumulated Man{sub 9}GlcNAc{sub 2}-P-P-Dol. CHO-K1 and MI5-4 cells both produced primarily the complete LLO, Glc{sub 3}Man{sub 9}GlcNAc{sub 2}-P-P-Dol, though the relative quantity was lower in MI5-4. MI5-4 cells have reduced hexokinase activity which could affect the availability of many of the substrates required for LLO synthesis and, consequently, impair production of the final LLO donor. Increasing hexokinase activity by overexpressing hexokinase II in MI5-4 caused a decrease in the relative quantities of the incomplete LLO intermediates from Man{sub 5}GlcNAc{sub 2}-PP-Dol through Glc{sub 1}Man{sub 9}GlcNAc{sub 2}-PP-Dol, and an increase in the relative quantity of the final LLO donor, Glc{sub 3}Man{sub 9}GlcNAc{sub 2}-P-P-Dol. This study suggests that metabolic engineering may be a useful strategy for improving LLO availability for use in N-glycosylation.

  6. Analysis of the link between a definition of sustainability and the life cycle methodologies

    DEFF Research Database (Denmark)

    Jørgensen, Andreas; Herrmann, Ivan Tengbjerg; Bjørn, Anders

    2013-01-01

    explicit analysis of the claim has been made. The purpose of this article is to analyse this claim.An interpretation of the goals of sustainability, as outlined in the report Our Common Future (WCED 1987), which is the basis for most literature on sustainability assessment in the LCA community......It has been claimed that in order to assess the sustainability of products, a combination of the results from a life cycle assessment (LCA), social life cycle assessment (SLCA) and life cycle costing (LCC) is needed. Despite the frequent reference to this claim in the literature, very little......, is presented and detailed to a level enabling an analysis of the relation to the impact categories at midpoint level considered in life cycle (LC) methodologies.The interpretation of the definition of sustainability as outlined in Our Common Future (WCED 1987) suggests that the assessment of a product...

  7. Accidental falls in hospitalized children: an analysis of the vulnerabilities linked to the presence of caregivers.

    Science.gov (United States)

    Bagnasco, A; Sobrero, M; Sperlinga, L; Tibaldi, L; Sasso, L

    2010-06-01

    This study stemmed from the data gathered by a research conducted by the coordinator of the Department of Healthcare Services and a group of nurses involved in a research on accidental falls in hospitalized children at the "G. Gaslini" Children's Hospital and Scientific Research Institute in Genoa, Italy. The first retrospective study evaluated the accidental falls in hospitalized children referred to the three-year period 2003-2006, while the second perspective study, referred to the trimester March-May 2007, found that the main cause of falls in children was parent's distraction. The method adopted in the first phase of our study was a proactive risk analysis (The Basics of Healthcare Failure Mode and Effect Analysis), identified in the first place by the VA National Centre for Patient Safety and applied to the "Child and parent hospital admission process". This proactive risk analysis has proven to be very effective in preventing the risk of accidental falls in hospitalized children through effective communication and educational interventions. The second phase of our study consisted of two Focus Groups for accidental traumatic events. The analysis of the results of the study showed how effective communication is instrumental, not only to have a better awareness of the children and their parents during their stay in hospital, but also to implement educational sessions on prevention to reduce the risk of accidental traumatic events. The present study contributes to improve safety and the quality of care by motivating nurses to keep their attention high on falls in hospitalized children, by monitoring and the development of new risk assessment tools.

  8. Multi-scale location analysis of vulnerabilities and their link to disturbances within digital ecosystems

    OpenAIRE

    Jackson, Jennifer

    2017-01-01

    As computer networks evolve, so too does the techniques used by attackers to exploit new vulnerabilities. Natural ecosystems already have resistant and resilient properties that help protect them from unwanted disturbances despite the existence of different vulnerabilities. Computer networks and their environments can be considered as digital ecosystems with different vulnerabilities, and security attacks can be considered as unwanted disturbances. Analysis of vulnerabilities and attacks from...

  9. Whole-Proteome Analysis of Twelve Species of Alphaproteobacteria Links Four Pathogens

    Directory of Open Access Journals (Sweden)

    Yunyun Zhou

    2013-11-01

    Full Text Available Thousands of whole-genome and whole-proteome sequences have been made available through advances in sequencing technology, and sequences of millions more organisms will become available in the coming years. This wealth of genetic information will provide numerous opportunities to enhance our understanding of these organisms including a greater understanding of relationships among species. Researchers have used 16S rRNA and other gene sequences to study the evolutionary origins of bacteria, but these strategies do not provide insight into the sharing of genes among bacteria via horizontal transfer. In this work we use an open source software program called pClust to cluster proteins from the complete proteomes of twelve species of Alphaproteobacteria and generate a dendrogram from the resulting orthologous protein clusters. We compare the results with dendrograms constructed using the 16S rRNA gene and multiple sequence alignment of seven housekeeping genes. Analysis of the whole proteomes of these pathogens grouped Rickettsia typhi with three other animal pathogens whereas conventional sequence analysis failed to group these pathogens together. We conclude that whole-proteome analysis can give insight into relationships among species beyond their phylogeny, perhaps reflecting the effects of horizontal gene transfer and potentially providing insight into the functions of shared genes by means of shared phenotypes.

  10. Numerical and Experimental Analysis of Aircraft Wing Subjected to Fatigue Loading

    Directory of Open Access Journals (Sweden)

    Hatem Rahim Wasmi

    2016-10-01

    Full Text Available This study deals with the aircraft wing analysis (numerical and experimental which subjected to fatigue loading in order to analyze the aircraft wing numerically by using ANSYS 15.0 software and experimentally by using loading programs which effect on fatigue test specimens at laboratory to estimate life of used metal (aluminum alloy 7075-T651 the wing metal and compare between numerical and experimental work, as well as to formulate an experimental mathematical model which may find safe estimate for metals and most common alloys that are used to build aircraft wing at certain conditions. In experimental work, a (34 specimen of (aluminum alloy 7075-T651 were tested using alternating bending fatigue machine rig. The test results are ; (18 Specimen to establish the (S-N curve and endurance limit and the other specimens used for variable amplitude tests were represented by loading programs which represents actual flight conditions. Also it has been obtained the safe fatigue curves which are described by mathematical formulas. ANSYS results show convergence with experimental results about cumulative fatigue damage (D, a mathematical model is proposed to estimate the life; this model gives good results in case of actual loading programs. Also, Miner and Marsh rules are applied to the specimens and compared with the proposal mathematical model in order to estimate the life of the wing material under actual flight loading conditions, comparing results show that it is possible to depend on present mathematical model than Miner and Marsh theories because the proposal mathematical model shows safe and good results compared with experimental work results.

  11. Microbial community stratification linked to utilization of carbohydrates and phosphorus limitation in a boreal peatland at Marcell Experimental Forest, Minnesota, USA.

    Science.gov (United States)

    Lin, Xueju; Tfaily, Malak M; Steinweg, J Megan; Chanton, Patrick; Esson, Kaitlin; Yang, Zamin K; Chanton, Jeffrey P; Cooper, William; Schadt, Christopher W; Kostka, Joel E

    2014-06-01

    This study investigated the abundance, distribution, and composition of microbial communities at the watershed scale in a boreal peatland within the Marcell Experimental Forest (MEF), Minnesota, USA. Through a close coupling of next-generation sequencing, biogeochemistry, and advanced analytical chemistry, a biogeochemical hot spot was revealed in the mesotelm (30- to 50-cm depth) as a pronounced shift in microbial community composition in parallel with elevated peat decomposition. The relative abundance of Acidobacteria and the Syntrophobacteraceae, including known hydrocarbon-utilizing genera, was positively correlated with carbohydrate and organic acid content, showing a maximum in the mesotelm. The abundance of Archaea (primarily crenarchaeal groups 1.1c and 1.3) increased with depth, reaching up to 60% of total small-subunit (SSU) rRNA gene sequences in the deep peat below the 75-cm depth. Stable isotope geochemistry and potential rates of methane production paralleled vertical changes in methanogen community composition to indicate a predominance of acetoclastic methanogenesis mediated by the Methanosarcinales in the mesotelm, while hydrogen-utilizing methanogens predominated in the deeper catotelm. RNA-derived pyrosequence libraries corroborated DNA sequence data to indicate that the above-mentioned microbial groups are metabolically active in the mid-depth zone. Fungi showed a maximum in rRNA gene abundance above the 30-cm depth, which comprised only an average of 0.1% of total bacterial and archaeal rRNA gene abundance, indicating prokaryotic dominance. Ratios of C to P enzyme activities approached 0.5 at the acrotelm and catotelm, indicating phosphorus limitation. In contrast, P limitation pressure appeared to be relieved in the mesotelm, likely due to P solubilization by microbial production of organic acids and C-P lyases. Based on path analysis and the modeling of community spatial turnover, we hypothesize that P limitation outweighs N limitation at

  12. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

  13. Experimental and theoretical analysis of a hybrid solar thermoelectric generator with forced convection cooling

    Science.gov (United States)

    Sundarraj, Pradeepkumar; Taylor, Robert A.; Banerjee, Debosmita; Maity, Dipak; Sinha Roy, Susanta

    2017-01-01

    Hybrid solar thermoelectric generators (HSTEGs) have garnered significant research attention recently due to their potential ability to cogenerate heat and electricity. In this paper, theoretical and experimental investigations of the electrical and thermal performance of a HSTEG system are reported. In order to validate the theoretical model, a laboratory scale HSTEG system (based on forced convection cooling) is developed. The HSTEG consists of six thermoelectric generator modules, an electrical heater, and a stainless steel cooling block. Our experimental analysis shows that the HSTEG is capable of producing a maximum electrical power output of 4.7 W, an electrical efficiency of 1.2% and thermal efficiency of 61% for an average temperature difference of 92 °C across the TEG modules with a heater power input of 382 W. These experimental results of the HSTEG system are found to be in good agreement with the theoretical prediction. This experimental/theoretical analysis can also serve as a guide for evaluating the performance of the HSTEG system with forced convection cooling.

  14. A Unified Performance Analysis of Free-Space Optical Links over Gamma-Gamma Turbulence Channels with Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique

    2013-11-13

    In this work, we present a unified performance analysis of a free-space optical (FSO) link that accounts for pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection as well as heterodyne detection). More specifically, we present unified exact closed-form expressions for the cumulative distribution function, the probability density function, the moment generating function, and the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system, all in terms of the Meijer\\'s G function except for the moments that is in terms of simple elementary functions. We then capitalize on these unified results to offer unified exact closed-form expressions for various performance metrics of FSO link transmission systems, such as, the outage probability, the higher-order amount of fading (AF), the average error rate for binary and M-ary modulation schemes, and the ergodic capacity, all in terms of Meijer\\'s G functions except for the higher-order AF that is in terms of simple elementary functions. Additionally, we derive the asymptotic results for all the expressions derived earlier in terms of Meijer\\'s G function in the high SNR regime in terms of simple elementary functions via an asymptotic expansion of the Meijer\\'s G function. We also derive new asymptotic expressions for the ergodic capacity in the low as well as high SNR regimes in terms of simple elementary functions via utilizing moments. All the presented results are verified via computer-based Monte-Carlo simulations.

  15. Temperature Regulation of Photovoltaic Module Using Phase Change Material: A Numerical Analysis and Experimental Investigation

    Directory of Open Access Journals (Sweden)

    Hasan Mahamudul

    2016-01-01

    Full Text Available This work represents an effective design of a temperature regulated PV module by integrating phase change materials for Malaysian weather condition. Through the numerical analysis and experimental investigation it has been shown that if a PCM layer of width 0.02 m of RT 35 is used as a cooling arrangement with a PV module, the surface temperature of the module is reduced by 10°C, which remains constant for a period of 4–6 hours. This reduction of temperature implies the increase in conversion efficiency of the module. Experiment as well as investigation has been carried out considering typical Malaysian weather. Obtained result has been validated by using experimental prototype and comparative analysis.

  16. 2000 CKM-triangle analysis a critical review with updated experimental inputs and theoretical parameters

    International Nuclear Information System (INIS)

    Roudeau, P.; Stocchi, A.; Ciuchini, M.; Lubicz, V.; D'Agostini, G.; Franco, E.; Martinelli, G.; Parodi, F.

    2000-12-01

    Within the Standard Model, a review of the current determination of the sides and angles of the CKM unitarity triangle is presented, using experimental constraints from the measurements of |ε K |, |V ub /V cb |, Δm d and from the limit on Δm s , available in September 2000. Results from the experimental search for B 0 s -B-bar 0 s oscillations are introduced in the present analysis using the likelihood. Special attention is devoted to the determination of the theoretical uncertainties. The purpose of the analysis is to infer regions where the parameters of interest lie with given probabilities. The BaBar '95% C.L. scanning' method is also commented. (authors)

  17. Experimental study on the operators' cognitive behavior analysis for the plant anomaly diagnosis

    International Nuclear Information System (INIS)

    Takahashi, Makoto; Kubo, Osamu; Yasuta, Akira

    1996-01-01

    In this paper, a method of human cognitive state estimation based on physiological measures has been applied to the analysis of cognitive behavior during anomaly diagnosis observed with nuclear power plant simulator. This method has also been combined with the conventional experimental protocol such as operational sequence and questionnaire results. The simulator experiments have been performed using plant experts and the results demonstrate that the cognitive state estimation method can be an effective way for understanding cognitive behavior during the anomaly diagnosis of the nuclear power plant. It has also been shown from the results that the combined use of the human cognitive state estimation and the conventional experimental protocol can provide effective information in decreasing the ambiguity of the analysis results. (author)

  18. A global analysis of recent experimental results: How well determined are the parton distribution functions?

    International Nuclear Information System (INIS)

    Morfin, J.G.

    1990-08-01

    Following is a brief summary of the results of an analysis of experimental data performed to extract the patron distribution functions. In contrast to other global analyses, this study investigated how the fit results depend on: Experimental Systematic Errors; Kinematic Cuts on the Analyzed Data and Choice of Initial Functional Forms, with a prime goal being a close look at the range of low-x behavior allowed by data. This is crucial for predictions for the SSC/LHC, HERA, and even at Tevatron Collider energies. Since all details can be found in the just released Fermilab preprint Parton Distributions from a Global QCD Analysis of Deep Inelastic Scattering and Lepton-Pair Production by J. G. M. and Wu-Ki Tung, this summary will be only a brief outline of major results. 11 refs., 13 figs

  19. Experimental analysis of influence of different lubricants types on the multi-phase ironing process

    Directory of Open Access Journals (Sweden)

    Milan Djordjević

    2013-05-01

    Full Text Available This paper is aimed at presenting results of an experimental analysis of the different types of lubricants influence on the multi-phase ironing process. Based on sliding of the metal strip between the two contact elements a special tribological model was adopted. The subject of experimental investigations was variations of the drawing force, contact pressure and the friction coefficient for each type of the applied lubricants. The ironing process was conducted in three-phases at the constant sliding velocity. The objective of this analysis was to compare all the applied lubricants in order to estimate their quality from the point of view of their applicability in the multi-phase ironing process.

  20. EXPERIMENTAL ANALYSIS OF INFLUENCE OF DIFFERENT LUBRICANTS TYPES ON THE MULTI-PHASE IRONING PROCESS

    Directory of Open Access Journals (Sweden)

    Milan Djordjević

    2013-09-01

    Full Text Available This paper is aimed at presenting results of an experimental analysis of the different types of lubricants influence on the multi-phase ironing process. Based on sliding of the metal strip between the two contact elements a special tribological model was adopted. The subject of experimental investigations was variations of the drawing force, contact pressure and the friction coefficient for each type of the applied lubricants. The ironing process was conducted in three-phases at the constant sliding velocity. The objective of this analysis was to compare all the applied lubricants in order to estimate their quality from the point of view of their applicability in the multi-phase ironing process.

  1. Linear elastic obstacles: analysis of experimental results in the case of stress dependent pre-exponentials

    International Nuclear Information System (INIS)

    Surek, T.; Kuon, L.G.; Luton, M.J.; Jones, J.J.

    1975-01-01

    For the case of linear elastic obstacles, the analysis of experimental plastic flow data is shown to have a particularly simple form when the pre-exponential factor is a single-valued function of the modulus-reduced stress. The analysis permits the separation of the stress and temperature dependence of the strain rate into those of the pre-exponential factor and the activation free energy. As a consequence, the true values of the activation enthalpy, volume and entropy also are obtained. The approach is applied to four sets of experimental data, including Zr, and the results for the pre-exponential term are examined for self-consistency in view of the assumed functional dependence

  2. [Dynamics of riboflavin level in aqueous humour of anterior chamber of experimental animals under standard stroma saturation by ultraviolet corneal cross-linking solutions].

    Science.gov (United States)

    Bikbov, M M; Shevchuk, N E; Khalimov, A R; Bikbova, G M

    To evaluate the dynamics of riboflavin changes in the aqueous humour of the anterior chamber (AHAC) of rabbits' eyes during standard ultraviolet (UV) cross-linking with account to the area of corneal debridement. Forty two rabbits were studied sequentially. The following solutions of riboflavin were used for cornea saturation: IR - 0.1% isosmotic riboflavin, D - Dextralink (0.1% riboflavin with 20% dextran), R - 0.1% riboflavin with 1.0% hydroxypropylmethylcellulose (HPMC). Each solution was evaluated in 3 groups that differed in the diameter of corneal debridement: group 1 - Epi-Off 3 mm (IR-3, D-3, P-3), group 2 - Epi-Off 6 mm (IR-6, D-6, R-6), and group 3 - Epi-Off 9 mm (IR-9, D-9, R-9). Aqueous humour sampling (252 samples in total) was performed in 10-minute intervals within a 60 minute period. Riboflavin levels were measured by enzyme-linked immunoassay (ID-Vit microbiological test system; Immundiagnostik, Germany). Stable growth rates of riboflavin level in the AHAC (with maximum values reached at 30-40 min) were observed for solutions D and R, regardless of the variant of corneal debridement. Moreover, throughout the whole follow-up period and regardless of the area of corneal debridement, the solution D provided a relatively lower concentration of riboflavin in the AHAC as compared to the two other solutions. At 30 minutes, when the cornea was considered ready for UV irradiation, the riboflavin level in the AHAC ranged from 385±26.1 μg/l (D-9) to 665±28 μg/l (R-9). In groups IR-9, IR-6, P-6, IR-3, and P-3 riboflavin levels were found to be in the same range starting at 20 minutes. However, even a sufficient concentration of riboflavin in the cornea or AHAC cannot guarantee safe and effective UV cross-linking, since the removed epithelium limits the area of the stroma that can be saturated with riboflavin, while the area of UV exposure is 8-10 mm. Safe and efficient standard UV cross-linking may be performed only under sufficient saturation of the

  3. Periodic analysis of solar activity and its link with the Arctic oscillation phenomenon

    Energy Technology Data Exchange (ETDEWEB)

    Qu, Weizheng; Li, Chun; Du, Ling; Huang, Fei [Ocean University of China, 14-1' -601, 2117 Jinshui Road, Qingdao 266100 (China); Li, Yanfang, E-mail: quweizhe@ouc.edu.cn [Yantai Institute of Coastal Zone Research Chinese Academy of Sciences (China)

    2014-12-01

    Based on spectrum analysis, we provide the arithmetic expressions of the quasi 11 yr cycle, 110 yr century cycle of relative sunspot numbers, and quasi 22 yr cycle of solar magnetic field polarity. Based on a comparative analysis of the monthly average geopotential height, geopotential height anomaly, and temperature anomaly of the northern hemisphere at locations with an air pressure of 500 HPa during the positive and negative phases of AO (Arctic Oscillation), one can see that the abnormal warming period in the Arctic region corresponds to the negative phase of AO, while the anomalous cold period corresponds to its positive phase. This shows that the abnormal change in the Arctic region is an important factor in determining the anomalies of AO. In accordance with the analysis performed using the successive filtering method, one can see that the AO phenomenon occurring in January shows a clear quasi 88 yr century cycle and quasi 22 yr decadal cycle, which are closely related to solar activities. The results of our comparative analysis show that there is a close inverse relationship between the solar activities (especially the solar magnetic field index changes) and the changes in the 22 yr cycle of the AO occurring in January, and that the two trends are basically opposite of each other. That is to say, in most cases after the solar magnetic index MI rises from the lowest value, the solar magnetic field turns from north to south, and the high-energy particle flow entering the Earth's magnetosphere increases to heat the polar atmosphere, thus causing the AO to drop from the highest value; after the solar magnetic index MI drops from the highest value, the solar magnetic field turns from south to north, and the solar high-energy particle flow passes through the top of the Earth's magnetosphere rather than entering it to heat the polar atmosphere. Thus the polar temperature drops, causing the AO to rise from the lowest value. In summary, the variance

  4. Bibliometric performance analysis of publications from Danish researchers linked to FP6 and FP7

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg; Ryan, Thomas Kjeldager

    2015-01-01

    This chapter presents an analysis29 of the impact of Danish scientific publications that were the result of FP6 or FP7 funding. The purpose is to gain an insight into the scientific impact researchers can achieve when participating in FP6 and FP7. In order to look at impact we have identified cit...... Foundation (DNRF) and the Danish Council for Independent Research (DFF). Finally the analyses also explore the impact at the level of programme themes under FP6 and FP7....

  5. THE LINK BETWEEN HUMAN DEVELOPMENT AND TAX COMPLIANCE: EVIDENCE FROM A MEDIATION ANALYSIS

    Directory of Open Access Journals (Sweden)

    BǍTRÂNCEA LARISSA

    2015-12-01

    Full Text Available By performing mediation analysis with the state-of-the-art bootstrapping technique (95% bias-corrected and accelerated confidence interval; 5000 bootstrap resamples on a worldwide sample pool of countries and territories, it is shown that human development level influences citizens’ decisions to comply with tax laws via trust in authorities. The higher the human development level, the more people tend to trust public authorities. As a result of the increase in public trust, citizens act in accordance with tax laws by honestly reporting taxable income and paying dues in time.

  6. Cover crops effect on farm benefits and nitrate leaching: linking economic and environmental analysis

    Science.gov (United States)

    Gabriel, José Luis; Vanclooster, Marnik; Garrido, Alberto; Quemada, Miguel

    2013-04-01

    Introducing cover crops interspersed with intensively fertilized crops in rotation has the potential to reduce nitrate leaching. However, despite the evident environmental services provided and the range of agronomic benefits documented in the literature, farmers' adoption of the technique is still limited because growing CC could lead to extra costs for the farm in three different forms: direct, indirect, and opportunity costs. Environmental studies are complex, and evaluating the indicators that are representative of the environmental impact of an agricultural system is a complicated task that is conducted by specialized groups and methodologies. Multidisciplinary studies may help to develop reliable approaches that would contribute to choosing the best agricultural strategies based on linking economic and environmental benefits. This study evaluates barley (Hordeum vulgare L., cv. Vanessa), vetch (Vicia villosa L., cv. Vereda) and rapeseed (Brassica napus L., cv. Licapo) as cover crops between maize, leaving the residue in the ground or selling it for animal feeding, and compares the economic and environmental results with respect to a typical maize-fallow rotation. Nitrate leaching for different weather conditions was calculated using the mechanistic-deterministic WAVE model, using the Richards equation parameterised with a conceptual model for the soil hydraulic properties for describing the water flow in the vadose zone, combined with field observed data. The economic impact was evaluated through stochastic (Monte-Carlo) simulation models of farms' profits using probability distribution functions of maize yield and cover crop biomass developed fitted with data collected from various field trials (during more than 5 years) and probability distribution functions of maize and different cover crop forage prices fitted from statistical sources. Stochastic dominance relationships are obtained to rank the most profitable strategies from a farm financial perspective

  7. Identifying controlling variables for math computation fluency through experimental analysis: the interaction of stimulus control and reinforcing consequences.

    Science.gov (United States)

    Hofstadter-Duke, Kristi L; Daly, Edward J

    2015-03-01

    This study investigated a method for conducting experimental analyses of academic responding. In the experimental analyses, academic responding (math computation), rather than problem behavior, was reinforced across conditions. Two separate experimental analyses (one with fluent math computation problems and one with non-fluent math computation problems) were conducted with three elementary school children using identical contingencies while math computation rate was measured. Results indicate that the experimental analysis with non-fluent problems produced undifferentiated responding across participants; however, differentiated responding was achieved for all participants in the experimental analysis with fluent problems. A subsequent comparison of the single-most effective condition from the experimental analyses replicated the findings with novel computation problems. Results are discussed in terms of the critical role of stimulus control in identifying controlling consequences for academic deficits, and recommendations for future research refining and extending experimental analysis to academic responding are made. © The Author(s) 2014.

  8. An experimental magnetic moment determination method based on spatial harmonic analysis of magnetic flux density signatures

    Directory of Open Access Journals (Sweden)

    A.V. Getman

    2013-12-01

    Full Text Available Theoretical aspects of an experimental determination method for residual and inductive magnetic moments of a technical object are considered. As input data, the technical object magnetic induction signatures obtained under its linear movement near a pair of three-component sensors are used. A magnetic signature integration technique based on spatial harmonic analysis of the magnetic field represented by twenty-four multipole coefficients is introduced.

  9. Characteristics of a micro-fin evaporator: Theoretical analysis and experimental verification

    OpenAIRE

    Zheng Hui-Fan; Fan Xiao-Wei; Wang Fang; Liang Yao-Hua

    2013-01-01

    A theoretical analysis and experimental verification on the characteristics of a micro-fin evaporator using R290 and R717 as refrigerants were carried out. The heat capacity and heat transfer coefficient of the micro-fin evaporator were investigated under different water mass flow rate, different refrigerant mass flow rate, and different inner tube diameter of micro-fin evaporator. The simulation results of the heat transfer coefficient are fairly in good a...

  10. Linear and nonlinear stability analysis, associated to experimental fast reactors. Part 2

    International Nuclear Information System (INIS)

    Amorim, E.S. do; Moura Neto, C. de; Rosa, M.A.P.

    1980-07-01

    The nonlinear effects in fast reactors kinetics and their stability are studied. The Lyapunov criteria and the Lurie-Letov functions for nonlinear systems were established and simulated. Small oscillations were studied by a Fourier analysis to clarify particular aspects of feedback and load functions in fast reactor at zero power, or/and in normal power level. The results were in agreement with the experimental data existing in the literature. (E.G.) [pt

  11. Numerical analysis of temperature field during hardfacing process and comparison with experimental results

    Directory of Open Access Journals (Sweden)

    Lazić Vukić N.

    2014-01-01

    Full Text Available The three-dimensional transient nonlinear thermal analysis of the hard facing process is performed by using the finite element method. The simulations were executed on the open source Salome platform using the open source finite element solver Code_Aster. The Gaussian double ellipsoid was selected in order to enable greater possibilities for the calculation of the moving heat source. The numerical results were compared with available experimental results.

  12. Ultrafast Gain Dynamics in Quantum Dot Amplifiers: Theoretical Analysis and Experimental Investigations

    DEFF Research Database (Denmark)

    Poel, Mike van der; Gehrig, Edeltraud; Hess, Ortwin

    2005-01-01

    Ultrafast gain dynamics in an optical amplifier with an active layer of self-organized quantum dots (QDs) emitting near 1.3$muhbox m$is characterized experimentally in a pump-probe experiment and modeled theoretically on the basis of QD Maxwell–Bloch equations. Experiment and theory are in good......$factor) is theoretically predicted and demonstrated in the experiments. The fundamental analysis reveals the underlying physical processes and indicates limitations to QD-based devices....

  13. Chemometrics in analytical chemistry-part I: history, experimental design and data analysis tools.

    Science.gov (United States)

    Brereton, Richard G; Jansen, Jeroen; Lopes, João; Marini, Federico; Pomerantsev, Alexey; Rodionova, Oxana; Roger, Jean Michel; Walczak, Beata; Tauler, Romà

    2017-10-01

    Chemometrics has achieved major recognition and progress in the analytical chemistry field. In the first part of this tutorial, major achievements and contributions of chemometrics to some of the more important stages of the analytical process, like experimental design, sampling, and data analysis (including data pretreatment and fusion), are summarised. The tutorial is intended to give a general updated overview of the chemometrics field to further contribute to its dissemination and promotion in analytical chemistry.

  14. Numerical and experimental analysis of the hydroelastic behavior of purse seine nets

    OpenAIRE

    Riziotis, V. A.; Katsaounis, G. M.; Papadakis, G.; Voutsinas, S. G.; Bergeles, G.; Tzabiras, G. D.

    2013-01-01

    The paper presents a general three dimensional hydro-elastic tool for the analysis of different types of fishing nets and aquaculture facilities. Flexible net strands are modeled by non-linear truss elements having two nodes. Hydrodynamic loads due to relative motion of the net with the surrounding fluid are computed using the Morison equation. The coupled hydrodynamic-elastodynamic equations are solved using finite element (FE) approximations. Furthermore, experimental data are presented for...

  15. Jones matrix formulation of a Porro prism laser resonator with waveplates: theoretical and experimental analysis

    Science.gov (United States)

    Agrawal, L.; Bhardwaj, A.; Pal, S.; Kumar, A.

    2007-11-01

    This article presents the results of a detailed theoretical and experimental analysis carried out on a folded Z-shaped polarization coupled, electro-optically Q-switched laser resonator with Porro prisms and waveplates. The advantages of adding waveplates in a Porro prism resonator have been explored for creating high loss condition prior to Q-switching and obtaining variable reflectivity with fixed orientation of Porro prism. Generalized expressions have been derived in terms of azimuth angles and phase shifts introduced by the polarizing elements. These expressions corroborate with known reported results under appropriate substitutions. A specific case of a crossed Porro prism diode-pumped Nd:YAG laser has been theoretically and experimentally investigated. In the feedback arm, a 0.57λ waveplate oriented at 135° completely compensates the phase shift of a fused silica Porro prism and provides better tolerances than a BK-7 prism/0.60λ waveplate combination to stop prelasing. The fused silica prism/0.57λ combination with waveplate at 112° acts like a 100% mirror and was utilized for optimization of free running performance. The effective reflectivity was determined for various orientations of the quarter waveplate in the gain arm to numerically estimate the Q-switched laser pulse parameters through rate equation analysis. Experimental results match well with the theoretical analysis.

  16. Analysis of the Spatial Variation of Network-Constrained Phenomena Represented by a Link Attribute Using a Hierarchical Bayesian Model

    Directory of Open Access Journals (Sweden)

    Zhensheng Wang

    2017-02-01

    Full Text Available The spatial variation of geographical phenomena is a classical problem in spatial data analysis and can provide insight into underlying processes. Traditional exploratory methods mostly depend on the planar distance assumption, but many spatial phenomena are constrained to a subset of Euclidean space. In this study, we apply a method based on a hierarchical Bayesian model to analyse the spatial variation of network-constrained phenomena represented by a link attribute in conjunction with two experiments based on a simplified hypothetical network and a complex road network in Shenzhen that includes 4212 urban facility points of interest (POIs for leisure activities. Then, the methods named local indicators of network-constrained clusters (LINCS are applied to explore local spatial patterns in the given network space. The proposed method is designed for phenomena that are represented by attribute values of network links and is capable of removing part of random variability resulting from small-sample estimation. The effects of spatial dependence and the base distribution are also considered in the proposed method, which could be applied in the fields of urban planning and safety research.

  17. Analysis and Optimization of Spiral Circular Inductive Coupling Link for Bio-Implanted Applications on Air and within Human Tissue

    Directory of Open Access Journals (Sweden)

    Saad Mutashar

    2014-06-01

    Full Text Available The use of wireless communication using inductive links to transfer data and power to implantable microsystems to stimulate and monitor nerves and muscles is increasing. This paper deals with the development of the theoretical analysis and optimization of an inductive link based on coupling and on spiral circular coil geometry. The coil dimensions offer 22 mm of mutual distance in air. However, at 6 mm of distance, the coils offer a power transmission efficiency of 80% in the optimum case and 73% in the worst case via low input impedance, whereas, transmission efficiency is 45% and 32%, respectively, via high input impedance. The simulations were performed in air and with two types of simulated human biological tissues such as dry and wet-skin using a depth of 6 mm. The performance results expound that the combined magnitude of the electric field components surrounding the external coil is approximately 98% of that in air, and for an internal coil, it is approximately 50%, respectively. It can be seen that the gain surrounding coils is almost constant and confirms the omnidirectional pattern associated with such loop antennas which reduces the effect of non-alignment between the two coils. The results also show that the specific absorption rate (SAR and power loss within the tissue are lower than that of the standard level. Thus, the tissue will not be damaged anymore.

  18. Nucleolar Proteome Analysis and Proteasomal Activity Assays Reveal a Link between Nucleolus and 26S Proteasome in A. thaliana

    Science.gov (United States)

    Montacié, Charlotte; Durut, Nathalie; Opsomer, Alison; Palm, Denise; Comella, Pascale; Picart, Claire; Carpentier, Marie-Christine; Pontvianne, Frederic; Carapito, Christine; Schleiff, Enrico; Sáez-Vásquez, Julio

    2017-01-01

    In all eukaryotic cells, the nucleolus is functionally and structurally linked to rRNA synthesis and ribosome biogenesis. This compartment contains as well factors involved in other cellular activities, but the functional interconnection between non-ribosomal activities and the nucleolus (structure and function) still remains an open question. Here, we report a novel mass spectrometry analysis of isolated nucleoli from Arabidopsis thaliana plants using the FANoS (Fluorescence Assisted Nucleolus Sorting) strategy. We identified many ribosome biogenesis factors (RBF) and proteins non-related with ribosome biogenesis, in agreement with the recognized multi-functionality of the nucleolus. Interestingly, we found that 26S proteasome subunits localize in the nucleolus and demonstrated that proteasome activity and nucleolus organization are intimately linked to each other. Proteasome subunits form discrete foci in the disorganized nucleolus of nuc1.2 plants. Nuc1.2 protein extracts display reduced proteasome activity in vitro compared to WT protein extracts. Remarkably, proteasome activity in nuc1.2 is similar to proteasome activity in WT plants treated with proteasome inhibitors (MG132 or ALLN). Finally, we show that MG132 treatment induces disruption of nucleolar structures in WT but not in nuc1.2 plants. Altogether, our data suggest a functional interconnection between nucleolus structure and proteasome activity. PMID:29104584

  19. Comprehensive experimental analysis of nonlinear dynamics in an optically-injected semiconductor laser

    Directory of Open Access Journals (Sweden)

    Kevin Schires

    2011-09-01

    Full Text Available We present the first comprehensive experimental study, to our knowledge, of the routes between nonlinear dynamics induced in a semiconductor laser under external optical injection based on an analysis of time-averaged measurements of the optical and RF spectra and phasors of real-time series of the laser output. The different means of analysis are compared for several types of routes and the benefits of each are discussed in terms of the identification and mapping of the nonlinear dynamics. Finally, the results are presented in a novel audio/video format that describes the evolution of the dynamics with the injection parameters.

  20. Experimental and Numerical Analysis of Screw Fixation in Anterior Cruciate Ligament Reconstruction

    Science.gov (United States)

    Chizari, Mahmoud; Wang, Bin; Snow, Martyn; Barrett, Mel

    2008-09-01

    This paper reports the results of an experimental and finite element analysis of tibial screw fixation in anterior cruciate ligament (ACL) reconstruction. The mechanical properties of the bone and tendon graft are obtained from experiments using porcine bone and bovine tendon. The results of the numerical study are compared with those from mechanical testing. Analysis shows that the model may be used to establish the optimum placement of the tunnel in anterior cruciate ligament reconstruction by predicting mechanical parameters such as stress, strain and displacement at regions in the tunnel wall.