WorldWideScience

Sample records for experimental analysis links

  1. Link Analysis

    Science.gov (United States)

    Donoho, Steve

    Link analysis is a collection of techniques that operate on data that can be represented as nodes and links. This chapter surveys a variety of techniques including subgraph matching, finding cliques and K-plexes, maximizing spread of influence, visualization, finding hubs and authorities, and combining with traditional techniques (classification, clustering, etc). It also surveys applications including social network analysis, viral marketing, Internet search, fraud detection, and crime prevention.

  2. Analytical and experimental analysis of a free link in contact with a granular medium.

    Science.gov (United States)

    Marghitu, Dan B; Lee, Seung

    2013-01-01

    In this study, the experimental and the simulation results for a planar free link impacting a granular medium are analyzed. The resistance force of the granular medium on the body from the moment of the impact until the body stops is very important. Horizontal and vertical static resistance forces developed by theoretical and empirical approaches are considered. The penetrating depth of the impacting end of the free link increases with the increase of the initial impacting velocity. We define the stopping time as the time interval from the moment of impact until the vertical velocity of the link end is zero. The stopping time of the end decreases as the initial velocity increases. The faster the end of the link impacts the surface of the granular medium, the sooner it will come to a stop. This phenomenon involves how rapidly a free link strikes the granular medium and how it slows down upon contact.

  3. Analytical and Experimental Analysis of a Free Link in Contact with a Granular Medium

    Directory of Open Access Journals (Sweden)

    Dan B. Marghitu

    2013-01-01

    Full Text Available In this study, the experimental and the simulation results for a planar free link impacting a granular medium are analyzed. The resistance force of the granular medium on the body from the moment of the impact until the body stops is very important. Horizontal and vertical static resistance forces developed by theoretical and empirical approaches are considered. The penetrating depth of the impacting end of the free link increases with the increase of the initial impacting velocity. We define the stopping time as the time interval from the moment of impact until the vertical velocity of the link end is zero. The stopping time of the end decreases as the initial velocity increases. The faster the end of the link impacts the surface of the granular medium, the sooner it will come to a stop. This phenomenon involves how rapidly a free link strikes the granular medium and how it slows down upon contact.

  4. Proteomic Profiling Analysis Reveals a Link between Experimental Autoimmune Uveitis and Complement Activation in Rats.

    Science.gov (United States)

    Guo, D D; Hu, B; Tang, H Y; Sun, Y Y; Liu, B; Tian, Q M; Bi, H S

    2017-05-01

    Uveitis is an autoimmune disease that usually damages the vision function, leading to poor visual quality in patients. As an autoimmune ocular inflammatory disease, the pathogenesis of uveitis is associated with abnormal expression of some proteins and aberrant regulation of multiple signalling pathways. Nevertheless, the detailed mechanism remains unclear. In this study, we induced an experimental autoimmune uveitis (EAU) model in rats. We determined the levels of C3a and membrane attack complex C5b-9 (soluble C5b-9, sC5b-9) in both plasma and aqueous humour, identified the differentially expressed proteins in plasma by liquid chromatography-tandem mass spectrometry and employed bioinformatics algorithms to analyse differentially expressed proteins in EAU rat plasma. The results demonstrate that there were 168 differentially expressed plasma proteins in EAU rats versus control subjects. The levels of sC5b-9 and C3a were elevated in the plasmas and aqueous humours of EAU rats. Gene ontology enrichment analysis showed that the differentially expressed proteins in EAU rat plasma were mainly involved in metabolic and immune processes. Kyoto encyclopedia of genes and genomes (KEGG) pathway annotation, database for annotation, visualization and integrated discovery (DAVID) and protein-protein interaction analyses revealed that the differentially expressed proteins in EAU rat plasmas were closely associated with complement and coagulation cascades, metabolic pathways, NF-kappa B, PI3K-Akt, Toll-like receptors and autophagy. Overall, the differentially expressed proteins in EAU rat plasmas are mainly involved in the complement and coagulation cascades. The pathogenesis of uveitis closely correlates with complement activation. © 2017 The Foundation for the Scandinavian Journal of Immunology.

  5. Experimental and Simulation Analysis for the Impact of a Two-Link Chain with Granular Matter

    Directory of Open Access Journals (Sweden)

    Eliza A. Banu

    2015-01-01

    Full Text Available The resistance force of the granular matter is modeled as a linear superposition of a static (quadratic depth-dependent resistance force and a dynamic (quadratic velocity-dependent frictional force. The impact is defined from the moment the end point of the system comes in contact with the granular matter surface until the vertical linear velocity of the end point is zero. The variables of interest are the final depth at the end of the penetration phase and the stopping time. The results for a two-link kinematic chain with two points of contact were compared to the results obtained by applying the resistance force formulation developed to corresponding CAD simulation models. The results revealed that the final displacement increases with initial velocity, while the stopping time decreases. The sensitivity to the initial velocity was studied and an improvement to the resistance force formulated as a result. A series of expressions are proposed for the resistance force coefficients.

  6. EXPERIMENTAL PERFORMANCE ANALYSIS OF WIRELESS ...

    African Journals Online (AJOL)

    EXPERIMENTAL PERFORMANCE ANALYSIS OF WIRELESS LINKS .... less reliable predictors of link quality. They recognised that the accuracy of the results of their work was, however, affected by delay im- posed by measurement window and the period of the ... a digital computer and analysing the results. Although.

  7. Experimental modal analysis

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Liingaard, Morten

    This technical report concerns the basic theory and principles for experimental modal analysis. The sections within the report are: Output-only modal analysis software (section 1.1), general digital analysis (section 1.2), basics of structural dynamics and modal analysis (section 1.3) and system...

  8. EUROSENTIMENT: Linked Data Sentiment Analysis

    OpenAIRE

    Sánchez Rada, Juan Fernando; Vulcu, Gabriela; Iglesias Fernandez, Carlos Angel; Buitelaar, Paul

    2014-01-01

    Sentiment and Emotion Analysis strongly depend on quality language resources, especially sentiment dictionaries. These resources are usually scattered, heterogeneous and limited to specific domains of appli- cation by simple algorithms. The EUROSENTIMENT project addresses these issues by 1) developing a common language resource representation model for sentiment analysis, and APIs for sentiment analysis services based on established Linked Data formats (lemon, Marl, NIF and ONYX) 2) by creati...

  9. Signed Link Analysis in Social Media Networks

    OpenAIRE

    Beigi, Ghazaleh; Tang, Jiliang; Liu, Huan

    2016-01-01

    Numerous real-world relations can be represented by signed networks with positive links (e.g., trust) and negative links (e.g., distrust). Link analysis plays a crucial role in understanding the link formation and can advance various tasks in social network analysis such as link prediction. The majority of existing works on link analysis have focused on unsigned social networks. The existence of negative links determines that properties and principles of signed networks are substantially dist...

  10. An Experimental Study of FSO Link Performance in Desert Environment

    KAUST Repository

    Esmail, Maged

    2016-06-29

    Free space optical (FSO) communication systems are affected by dust particles suspended in the atmosphere in arid and semi-arid regions. The presence of these particles in the air severely affects the optical link, reduces its availability and causes service outage. In the literature, the effect of dust on the microwave signals has been widely investigated. However, for FSO communication systems that exploit shorter wavelengths, information and research is still very limited yet almost inexistent. Therefore, in this paper, we investigate the performance of FSO links under dust storms. We designed a chamber to emulate this specific environment and carry out measurements. From the experimental investigations, we derive and propose an empirical model for the signal attenuation as a function of the visibility range. The results show acceptable performance for FSO links, under moderate and light dust, with potential reach distance of hundreds of meters to few kilometers. Furthermore, a comparison analysis shows that the dust induces 7 times higher attenuation than fog.

  11. Link Analysis for Space Communication Links Using ARQ Protocol

    Science.gov (United States)

    Cheung, Kar-Ming; Lau, Chi-Wung; Lee, Charles

    2014-01-01

    In space communications, standard link analysis assumes that messages are sent once. For a communication link that uses an error-correction coding scheme, bit-error-rate (BER) or frame-error-rate (FER), and link margins are common metrics that characterize the quality of a link, and they are used to determine the supportable data rate. With the advent of Automatic Repeat-reQuest (ARQ) protocols, when messages are corrupted during transmission, they can be resent multiple times automatically until they are correctly received and acknowledged. The concept of BER, FER, and link margin cannot be directly applied, and the link analysis approach for ARQ links needs to be re-examined.

  12. Socialization instances linked to cannabis experimentation among French teenagers.

    Science.gov (United States)

    Jovic, Sonia; Genolini, Christophe; Delpierre, Cyrille; Spilka, Stanislas; Ehlinger, Virginie; Ross, Jim; Arnaud, Catherine; Godeau, Emmanuelle

    2014-11-01

    France presents one of the highest prevalence of teenagers aged 15-year-olds who report they already have experienced cannabis in Europe. Data from the French 2010 Health Behavior in School-aged Children (HSBC) survey and environmental parameters typifying schools' neighborhoods were used to study cannabis experimentation. We conducted a two-level logistic regression (clusters being schools) on 4,175 French 8th-10th graders from 156 schools. Several individual parameters were linked to cannabis experimentation. Living in a non-intact family, feeling insufficiently monitored, having poor communication with mother and being from a family with a high socio-economic status (SES) were all associated with increased risk of cannabis experimentation. At environmental level, only being in a priority education area was linked to this behavior, without explaining differences among schools.

  13. Web Applications of Bibliometrics and Link Analysis

    Directory of Open Access Journals (Sweden)

    Faribourz Droudi

    2010-04-01

    Full Text Available The present study aims to introduce and analyze bibliometric application within Web and also to expounds on the status of link analysis in order to point out its application with respect to the existing web-based information sources. Findings indicate that bibliometrics could have required application in the area of digital resources available through Net. Link analysis is a process by which one could make statistical analysis of correlation between hyperlinks and therefore understand the accuracy, veracity and efficacy of citations within a digital document. Link analysis, in effect, is counted as a part of information ranking algorithm within the web environment. The number, linkage and quality of given links to a website are of utmost importance for ranking/status in the Web. The tools applied in this topic include, page ranking strategy, link analysis algorithm, latent semantic indexing and the classical input-output model. The present study analyzes Big Web and Small Web link analysis and explains the means for utilizing web charts in order to better understand the link analysis process.

  14. Experimental verification of Landauer's principle linking information and thermodynamics.

    Science.gov (United States)

    Bérut, Antoine; Arakelyan, Artak; Petrosyan, Artyom; Ciliberto, Sergio; Dillenschneider, Raoul; Lutz, Eric

    2012-03-07

    In 1961, Rolf Landauer argued that the erasure of information is a dissipative process. A minimal quantity of heat, proportional to the thermal energy and called the Landauer bound, is necessarily produced when a classical bit of information is deleted. A direct consequence of this logically irreversible transformation is that the entropy of the environment increases by a finite amount. Despite its fundamental importance for information theory and computer science, the erasure principle has not been verified experimentally so far, the main obstacle being the difficulty of doing single-particle experiments in the low-dissipation regime. Here we experimentally show the existence of the Landauer bound in a generic model of a one-bit memory. Using a system of a single colloidal particle trapped in a modulated double-well potential, we establish that the mean dissipated heat saturates at the Landauer bound in the limit of long erasure cycles. This result demonstrates the intimate link between information theory and thermodynamics. It further highlights the ultimate physical limit of irreversible computation.

  15. Link Analysis in the Mission Planning Lab

    Science.gov (United States)

    McCarthy, Jessica A.; Cervantes, Benjamin W.; Daugherty, Sarah C.; Arroyo, Felipe; Mago, Divyang

    2011-01-01

    The legacy communications link analysis software currently used at Wallops Flight Facility involves processes that are different for command destruct, radar, and telemetry. There is a clear advantage to developing an easy-to-use tool that combines all the processes in one application. Link Analysis in the Mission Planning Lab (MPL) uses custom software and algorithms integrated with Analytical Graphics Inc. Satellite Toolkit (AGI STK). The MPL link analysis tool uses pre/post-mission data to conduct a dynamic link analysis between ground assets and the launch vehicle. Just as the legacy methods do, the MPL link analysis tool calculates signal strength and signal- to-noise according to the accepted processes for command destruct, radar, and telemetry assets. Graphs and other custom data are generated rapidly in formats for reports and presentations. STK is used for analysis as well as to depict plume angles and antenna gain patterns in 3D. The MPL has developed two interfaces with the STK software (see figure). The first interface is an HTML utility, which was developed in Visual Basic to enhance analysis for plume modeling and to offer a more user friendly, flexible tool. A graphical user interface (GUI) written in MATLAB (see figure upper right-hand corner) is also used to quickly depict link budget information for multiple ground assets. This new method yields a dramatic decrease in the time it takes to provide launch managers with the required link budgets to make critical pre-mission decisions. The software code used for these two custom utilities is a product of NASA's MPL.

  16. linkedISA: semantic representation of ISA-Tab experimental metadata.

    Science.gov (United States)

    González-Beltrán, Alejandra; Maguire, Eamonn; Sansone, Susanna-Assunta; Rocca-Serra, Philippe

    2014-01-01

    Reporting and sharing experimental metadata- such as the experimental design, characteristics of the samples, and procedures applied, along with the analysis results, in a standardised manner ensures that datasets are comprehensible and, in principle, reproducible, comparable and reusable. Furthermore, sharing datasets in formats designed for consumption by humans and machines will also maximize their use. The Investigation/Study/Assay (ISA) open source metadata tracking framework facilitates standards-compliant collection, curation, visualization, storage and sharing of datasets, leveraging on other platforms to enable analysis and publication. The ISA software suite includes several components used in increasingly diverse set of life science and biomedical domains; it is underpinned by a general-purpose format, ISA-Tab, and conversions exist into formats required by public repositories. While ISA-Tab works well mainly as a human readable format, we have also implemented a linked data approach to semantically define the ISA-Tab syntax. We present a semantic web representation of the ISA-Tab syntax that complements ISA-Tab's syntactic interoperability with semantic interoperability. We introduce the linkedISA conversion tool from ISA-Tab to the Resource Description Framework (RDF), supporting mappings from the ISA syntax to multiple community-defined, open ontologies and capitalising on user-provided ontology annotations in the experimental metadata. We describe insights of the implementation and how annotations can be expanded driven by the metadata. We applied the conversion tool as part of Bio-GraphIIn, a web-based application supporting integration of the semantically-rich experimental descriptions. Designed in a user-friendly manner, the Bio-GraphIIn interface hides most of the complexities to the users, exposing a familiar tabular view of the experimental description to allow seamless interaction with the RDF representation, and visualising descriptors to

  17. Linking the Grain Scale to Experimental Measurements and Other Scales

    Science.gov (United States)

    Vogler, Tracy

    2017-06-01

    A number of physical processes occur at the scale of grains that can have a profound influence on the behavior of materials under shock loading. Examples include inelastic deformation, pore collapse, fracture, friction, and internal wave reflections. In some cases such as the initiation of energetics and brittle fracture, these processes can have first order effects on the behavior of materials: the emergent behavior from the grain scale is the dominant one. In other cases, many aspects of the bulk behavior can be described by a continuum description, but some details of the behavior are missed by continuum descriptions. The multi-scale model paradigm envisions flow of information from smaller scales (atomic, dislocation, etc.) to the grain or mesoscale and the up to the continuum scale. A significant challenge in this approach is the need to validate each step. For the grain scale, diagnosing behavior is challenging because of the small spatial and temporal scales involved. Spatially resolved diagnostics have begun to shed light on these processes, and, more recently, advanced light sources have started to be used to probe behavior at the grain scale. In this talk, I will discuss some interesting phenomena that occur at the grain scale in shock loading, experimental approaches to probe the grain scale, and efforts to link the grain scale to smaller and larger scales. Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE.

  18. Linking anthropological analysis and epidemiological evidence ...

    African Journals Online (AJOL)

    of Pierre Bourdieu is “violence which is exercised upon a social agent with his or her complicity”. (Bourdieu & Wacquant 2004, p. 272). Bourdieu. Journal of Social Aspects of HIV/AIDS. VOL. 4 NO. 2 AUGUST 2007. 594. ORIGINAL ARTICLE. Linking anthropological analysis and epidemiological evidence: Formulating a ...

  19. Software for an Experimental Air-Ground Data Link : Volume 2. System Operation Manual

    Science.gov (United States)

    1975-10-01

    This report documents the complete software system developed for the Experimental Data Link System which was implemented for flight test during the Air-Ground Data Link Development Program (FAA-TSC- Project Number FA-13). The software development is ...

  20. Linking Experimental Characterization and Computational Modeling in Microstructural Evolution

    Energy Technology Data Exchange (ETDEWEB)

    Demirel, Melik Cumhar [Univ. of Pittsburgh, PA (United States)

    2002-06-01

    It is known that by controlling microstructural development, desirable properties of materials can be achieved. The main objective of our research is to understand and control interface dominated material properties, and finally, to verify experimental results with computer simulations. In order to accomplish this objective, we studied the grain growth in detail with experimental techniques and computational simulations. We obtained 5170-grain data from an Aluminum-film (120μm thick) with a columnar grain structure from the Electron Backscattered Diffraction (EBSD) measurements. Experimentally obtained starting microstructure and grain boundary properties are input for the three-dimensional grain growth simulation. In the computational model, minimization of the interface energy is the driving force for the grain boundary motion. The computed evolved microstructure is compared with the final experimental microstructure, after annealing at 550 ºC. Two different measures were introduced as methods of comparing experimental and computed microstructures. Modeling with anisotropic mobility explains a significant amount of mismatch between experiment and isotropic modeling. We have shown that isotropic modeling has very little predictive value. Microstructural evolution in columnar Aluminum foils can be correctly modeled with anisotropic parameters. We observed a strong similarity between grain growth experiments and anisotropic three-dimensional simulations.

  1. Linking Experimental Characterization and Computational Modeling in Microstructural Evolution

    Energy Technology Data Exchange (ETDEWEB)

    Demirel, Melik Cumhur [Univ. of California, Berkeley, CA (United States)

    2002-06-01

    It is known that by controlling microstructural development, desirable properties of materials can be achieved. The main objective of our research is to understand and control interface dominated material properties, and finally, to verify experimental results with computer simulations. In order to accomplish this objective, we studied the grain growth in detail with experimental techniques and computational simulations. We obtained 5170-grain data from an Aluminum-film (120μm thick) with a columnar grain structure from the Electron Backscattered Diffraction (EBSD) measurements. Experimentally obtained starting microstructure and grain boundary properties are input for the three-dimensional grain growth simulation. In the computational model, minimization of the interface energy is the driving force for the grain boundary motion. The computed evolved microstructure is compared with the final experimental microstructure, after annealing at 550 ºC. Two different measures were introduced as methods of comparing experimental and computed microstructures. Modeling with anisotropic mobility explains a significant amount of mismatch between experiment and isotropic modeling. We have shown that isotropic modeling has very little predictive value. Microstructural evolution in columnar Aluminum foils can be correctly modeled with anisotropic parameters. We observed a strong similarity

  2. Historical Links between Latin American Psychology and Pedagogy in Experimentation

    Science.gov (United States)

    Arias, Walter L.

    2014-01-01

    This work sets out historical information about the development of Latin American psychology over the base of education. It reviews the contribution from education to Latin American psychology, and especially, the creation of experimental psychology laboratories in schools and educational and psychopedagogical institutions, where experimental…

  3. linkedISA: semantic representation of ISA-Tab experimental metadata

    National Research Council Canada - National Science Library

    González-Beltrán, Alejandra; Maguire, Eamonn; Sansone, Susanna-Assunta; Rocca-Serra, Philippe

    2014-01-01

    Reporting and sharing experimental metadata- such as the experimental design, characteristics of the samples, and procedures applied, along with the analysis results, in a standardised manner ensures...

  4. Deep Space Optical Link ARQ Performance Analysis

    Science.gov (United States)

    Clare, Loren; Miles, Gregory

    2016-01-01

    Substantial advancements have been made toward the use of optical communications for deep space exploration missions, promising a much higher volume of data to be communicated in comparison with present -day Radio Frequency (RF) based systems. One or more ground-based optical terminals are assumed to communicate with the spacecraft. Both short-term and long-term link outages will arise due to weather at the ground station(s), space platform pointing stability, and other effects. To mitigate these outages, an Automatic Repeat Query (ARQ) retransmission method is assumed, together with a reliable back channel for acknowledgement traffic. Specifically, the Licklider Transmission Protocol (LTP) is used, which is a component of the Disruption-Tolerant Networking (DTN) protocol suite that is well suited for high bandwidth-delay product links subject to disruptions. We provide an analysis of envisioned deep space mission scenarios and quantify buffering, latency and throughput performance, using a simulation in which long-term weather effects are modeled with a Gilbert -Elliot Markov chain, short-term outages occur as a Bernoulli process, and scheduled outages arising from geometric visibility or operational constraints are represented. We find that both short- and long-term effects impact throughput, but long-term weather effects dominate buffer sizing and overflow losses as well as latency performance.

  5. Inter-satellite laser link simulation analysis

    Science.gov (United States)

    Tong, Lanjuan; Guan, Hui; Wang, Zhilin

    2015-11-01

    The characteristic of satellite communication link was firstly described and four application modes were put forward. By comparison, it is suggested that microwave link is used in satellite-to-ground communication and laser link is used in inter-satellite communication. Secondly the condition and composition of laser link establishment was analyzed and laser link model was set up, and the principle and composition of APT system was described. Finally, based on STK and MATLAB platform, the process of inter-satellite laser link establishment was designed, and setting the scene of TDRS capturing and tracking user's satellite as an example, simulation was realized and demonstrated.

  6. Linking advanced fracture models to structural analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chiesa, Matteo

    2001-07-01

    Shell structures with defects occur in many situations. The defects are usually introduced during the welding process necessary for joining different parts of the structure. Higher utilization of structural materials leads to a need for accurate numerical tools for reliable prediction of structural response. The direct discretization of the cracked shell structure with solid finite elements in order to perform an integrity assessment of the structure in question leads to large size problems, and makes such analysis infeasible in structural application. In this study a link between local material models and structural analysis is outlined. An ''ad hoc'' element formulation is used in order to connect complex material models to the finite element framework used for structural analysis. An improved elasto-plastic line spring finite element formulation, used in order to take cracks into account, is linked to shell elements which are further linked to beam elements. In this way one obtain a global model of the shell structure that also accounts for local flexibilities and fractures due to defects. An important advantage with such an approach is a direct fracture mechanics assessment e.g. via computed J-integral or CTOD. A recent development in this approach is the notion of two-parameter fracture assessment. This means that the crack tip stress tri-axiality (constraint) is employed in determining the corresponding fracture toughness, giving a much more realistic capacity of cracked structures. The present thesis is organized in six research articles and an introductory chapter that reviews important background literature related to this work. Paper I and II address the performance of shell and line spring finite elements as a cost effective tool for performing the numerical calculation needed to perform a fracture assessment. In Paper II a failure assessment, based on the testing of a constraint-corrected fracture mechanics specimen under tension, is

  7. Simulation of turbulences and fog effects on the free space optical link inside of experimental box

    Science.gov (United States)

    Latal, Jan; Vitasek, Jan; Hajek, Lukas; Vanderka, Ales; Koudelka, Petr; Kepak, Stanislav; Vasinek, Vladimir

    2016-12-01

    This paper deals with problematic of Free Space Optical (FSO) Links. The theoretical part describes the effects of atmospheric transmission environment on these FSO connections. The practical part is focused on the creation of an appropriate experimental workplace for turbulences simulation (mechanical and thermal turbulences), fog effects and subsequent measurement of these effects. For definition how big impact these effects on the FSO system have is used the statistical analysis and simulation software Optiwave. Overall there were tested three optical light sources operating at wavelengths of 632.8 nm, 850 nm and 1550 nm respectively. Influences of simulated atmospheric effects on the signal attenuation were observed. Within the frame of simulation in Optiwave software there were studied influences of attenuation on given wavelengths in form of FSO link transmission parameters degradation. Also for the purposes of real measurements it was necessary to fabricate an experimental box. This box was constructed with sizes of 2.5 and 5 meters and was used for simulation of atmospheric environment.

  8. Linking water age and solute dynamics in streamflow at the Hubbard Brook Experimental Forest, NH, USA

    Science.gov (United States)

    Paolo Benettin; Scott W. Bailey; John L. Campbell; Mark B. Green; Andrea Rinaldo; Gene E. Likens; Kevin J. McGuire; Gianluca Botter

    2015-01-01

    We combine experimental and modeling results from a headwater catchment at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA, to explore the link between stream solute dynamics and water age. A theoretical framework based on water age dynamics, which represents a general basis for characterizing solute transport at the catchment scale, is here applied to...

  9. CULTURAL LINK ANALYSIS OF JAPANESE AMERICANS

    National Research Council Canada - National Science Library

    Yamaoka, Kazue; Hayashi, Chikio

    2003-01-01

    Using survey results of Japanese Americans (JA) living on the West Coast of the USA in 1998, and JA and non-JA living in Hawaii in 1999-2000, we examined cultural links between native Japanese, JAs, and Americans...

  10. Experimental analysis of armouring process

    Science.gov (United States)

    Lamberti, Alberto; Paris, Ennio

    Preliminary results from an experimental investigation on armouring processes are presented. Particularly, the process of development and formation of the armour layer under different steady flow conditions has been analyzed in terms of grain size variations and sediment transport rate associated to each size fraction.

  11. Left-handedness is statistically linked to lifetime experimentation with illicit drugs.

    Science.gov (United States)

    Preti, Antonio; Usai, Ileana; Pintus, Elisa; Sardu, Cinzia; Petretto, Donatella Rita; Masala, Carmelo

    2012-01-01

    Handedness has been linked to an enhanced risk of alcohol abuse, while less is known about other drugs. A convenience sample of 1004 male and female Italian participants (females=58%) from the general community (18 to 65 years old: average age = 30; standard deviation = 10, median = 25) was asked about: handedness (preference in writing); lifetime use of alcohol, tobacco, and illicit drugs; levels of psychological distress, as measured by the General Health Questionnaire (GHQ); and levels of delusion proneness, as measured by the Peters et al. Delusions Inventory (PDI). Overall, 92 individuals (9.2%) were classified as left-handed, with no significant difference reported among genders. Lifetime use of illicit drugs, primarily cannabis, was reported by 20% of the sample. In a multiple logistic regression analysis, after taking into account sex, age, and caseness on GHQ and PDI, left-handed people in the sample were statistically more likely to report lifetime experimentation with heroin, ecstasy/amphetamine, and, marginally, hallucinogens, but not alcohol or tobacco. Different mechanisms might contribute to an explanation of greater lifetime experimentation with some illicit drugs among left-handed people as compared to right-handed people. However, replications with clinical samples are necessary before any definitive statements can be made.

  12. Experimental Evaluation of TCP-Based DTN for Cislunar Communications in Presence of Long Link Disruption

    Directory of Open Access Journals (Sweden)

    Zhang Zhensheng

    2011-01-01

    Full Text Available Delay/disruption tolerant networking (DTN technology is considered a new solution to highly stressed communications in space environments. To date, little work has been done in evaluating the effectiveness and performance of the available DTN protocols when they are applied to an interplanetary Internet, especially in presence of a long link disruption. In this paper, we present an experimental investigation of the DTN architecture with a Bundle Protocol (BP running over TCP-based convergence layer (TCPCL protocol in a simulated cislunar communication environment characterized by a long link disruption. The intent of this work is to investigate the effectiveness of the TCPCL-based DTN protocol in coping with long link disruptions, through realistic file transfer experiments using a PC-based test-bed. The experiment results show that the DTN protocol is effective in handling a long link disruption experienced in data transmission accompanied by a cislunar link delay and a high BER. The performance of the DTN is most adversely affected by link disruption time in comparison to the effect of link delay and BER. For the transmissions with a very long link disruption of hours, the variations in goodput are nominal with respect to the change in cislunar link delay.

  13. Problem Formulation and Analysis of the 1-Hop ARQ Links

    Science.gov (United States)

    Cheung, K.-M.

    2013-08-01

    In space communications, standard link analysis assumes that messages are sent once. For a communication link that uses an error-correction coding scheme, bit-error rate (BER) or frame-error rate (FER), and link margins are common metrics that characterize the quality of a link, and they are used to determine the supportable data rate. With the advent of Automatic Repeat-reQuest (ARQ) protocols, when messages are corrupted during transmission, they can be resent multiple times automatically until they are correctly received and acknowledged. The concept of BER, FER, and link margin cannot be directly applied, and the link analysis approach for ARQ links needs to be reexamined. In this article, we provide the problem formulation and extend the standard link analysis approach to a 1-hop ARQ link (no routing), under the assumption that code-block errors occur independently as in the case of space communications. We develop analytical models that describe the statistical behavior of standard 1-hop ARQ links. By integrating these analytical ARQ protocol models into the standard link analysis, we bypass the need to simulate or emulate the ARQ protocol operations, and generate relevant statistics on effective data rate, effective throughput, latency, and FER.

  14. Wallops Low Elevation Link Analysis for the Constellation Launch/Ascent Links

    Science.gov (United States)

    Cheung, Keith; Ho, C.; Kantak, A.; Lee, C.; Tye, R.; Richards, E.; Sham, C.; Schlesinger, A.; Barritt, B.

    2011-01-01

    To execute the President's Vision for Space Exploration, the Constellation Program (CxP) was formed to build the next generation spacecraft Orion and launch vehicles Ares, to transport human and cargo to International Space Station (ISS), moon, and Mars. This paper focuses on the detailed link analysis for Orion/Ares s launch and ascent links with Wallops 11.3m antenna (1) Orion's Dissimilar Voice link: 10.24 Kbps, 2-way (2) Ares Developmental Flight Instrument link, 20 Mbps, downlink. Three launch trajectories are considered: TD7-E, F (Feb), and G (Aug). In certain launch scenarios, the critical events of main engine cutoff (MECO) and Separation occur during the low elevation regime of WFF s downrange -- less than 5 degree elevation angle. The goal of the study is to access if there is enough link margins for WFF to track the DV and DFI links.

  15. End-point controller design for an experimental two-link flexible manipulator using convex optimization

    Science.gov (United States)

    Oakley, Celia M.; Barratt, Craig H.

    1990-01-01

    Recent results in linear controller design are used to design an end-point controller for an experimental two-link flexible manipulator. A nominal 14-state linear-quadratic-Gaussian (LQG) controller was augmented with a 528-tap finite-impulse-response (FIR) filter designed using convex optimization techniques. The resulting 278-state controller produced improved end-point trajectory tracking and disturbance rejection in simulation and experimentally in real time.

  16. Kojak: efficient analysis of chemically cross-linked protein complexes.

    Science.gov (United States)

    Hoopmann, Michael R; Zelter, Alex; Johnson, Richard S; Riffle, Michael; MacCoss, Michael J; Davis, Trisha N; Moritz, Robert L

    2015-05-01

    Protein chemical cross-linking and mass spectrometry enable the analysis of protein-protein interactions and protein topologies; however, complicated cross-linked peptide spectra require specialized algorithms to identify interacting sites. The Kojak cross-linking software application is a new, efficient approach to identify cross-linked peptides, enabling large-scale analysis of protein-protein interactions by chemical cross-linking techniques. The algorithm integrates spectral processing and scoring schemes adopted from traditional database search algorithms and can identify cross-linked peptides using many different chemical cross-linkers with or without heavy isotope labels. Kojak was used to analyze both novel and existing data sets and was compared to existing cross-linking algorithms. The algorithm provided increased cross-link identifications over existing algorithms and, equally importantly, the results in a fraction of computational time. The Kojak algorithm is open-source, cross-platform, and freely available. This software provides both existing and new cross-linking researchers alike an effective way to derive additional cross-link identifications from new or existing data sets. For new users, it provides a simple analytical resource resulting in more cross-link identifications than other methods.

  17. Stress analysis of a link for slat chain conveyor

    Directory of Open Access Journals (Sweden)

    Tsonev Veselin

    2017-01-01

    Full Text Available This paper analyzes stresses in a link of a slat chain conveyor loaded with rock mass. Tensometric data and results from numerical simulation with Finite Element Method (FEM are used. The tensometric measurements are performed in real life conditions. For numerical simulation an adequate model with FEM has been created. The adequacy of the model is confirmed by the comparison of the experimental and numerical results. The factor of safety used in the design of the conveyor links is determined.

  18. Data Analysis in Experimental Biomedical Research

    DEFF Research Database (Denmark)

    Markovich, Dmitriy

    This thesis covers two non-related topics in experimental biomedical research: data analysis in thrombin generation experiments (collaboration with Novo Nordisk A/S), and analysis of images and physiological signals in the context of neurovascular signalling and blood flow regulation in the brain...... (collaboration with University of Copenhagen). The ongoing progress in experimental methods of thrombin generation allowed to introduce ready-to-use commercial assays for thrombin measurement. On the other hand, commercial assays use “black box” data analysis which makes it nearly impossible for researches...... to critically assess and compare obtained results. We reverse engineered the data analysis performed by CAT, a de facto standard assay in the field. This revealed a number of possibilities to improve its methods of data analysis. We found that experimental calibration data is described well with textbook...

  19. Linking Safety Analysis to Safety Requirements

    DEFF Research Database (Denmark)

    Hansen, Kirsten Mark

    Software for safety critical systems must deal with the hazards identified by safety analysistechniques: Fault trees, event trees,and cause consequence diagrams can be interpreted as safety requirements and used in the design activity. We propose that the safety analysis and the system design use...... the same system model and that this model is formalized in a real-time, interval logic, based on a conventional dynamic systems model with a state over time. The three safety analysis techniques are interpreted in this model and it is shown how to derive safety requirements for components of a system....

  20. R dump converter without DC link capacitor for an 8/6 SRM: experimental investigation.

    Science.gov (United States)

    Kavitha, Pasumalaithevan; Umamaheswari, Bhaskaran

    2015-01-01

    The objective of this paper is to investigate the performance of 8/6 switched reluctance motor (SRM) when excited with sinusoidal voltage. The conventional R dump converter provides DC excitation with the help of capacitor. In this paper the converter used is the modified R dump converter without DC link capacitor providing AC or sinusoidal excitation. Torque ripple and speed ripple are investigated based on hysteresis current control. Constant and sinusoidal current references are considered for comparison in both DC and AC excitation. Extensive theoretical and experimental investigations are made to bring out the merits and demerits of AC versus DC excitation. It is shown that the constructionally simple SRM can be favorably controlled with simple R dump converter with direct AC excitation without need for DC link capacitor. A 4-phase 8/6 0.5 kW SRM is used for experimentation.

  1. R Dump Converter without DC Link Capacitor for an 8/6 SRM: Experimental Investigation

    Directory of Open Access Journals (Sweden)

    Pasumalaithevan Kavitha

    2015-01-01

    Full Text Available The objective of this paper is to investigate the performance of 8/6 switched reluctance motor (SRM when excited with sinusoidal voltage. The conventional R dump converter provides DC excitation with the help of capacitor. In this paper the converter used is the modified R dump converter without DC link capacitor providing AC or sinusoidal excitation. Torque ripple and speed ripple are investigated based on hysteresis current control. Constant and sinusoidal current references are considered for comparison in both DC and AC excitation. Extensive theoretical and experimental investigations are made to bring out the merits and demerits of AC versus DC excitation. It is shown that the constructionally simple SRM can be favorably controlled with simple R dump converter with direct AC excitation without need for DC link capacitor. A 4-phase 8/6 0.5 kW SRM is used for experimentation.

  2. R Dump Converter without DC Link Capacitor for an 8/6 SRM: Experimental Investigation

    Science.gov (United States)

    Kavitha, Pasumalaithevan; Umamaheswari, Bhaskaran

    2015-01-01

    The objective of this paper is to investigate the performance of 8/6 switched reluctance motor (SRM) when excited with sinusoidal voltage. The conventional R dump converter provides DC excitation with the help of capacitor. In this paper the converter used is the modified R dump converter without DC link capacitor providing AC or sinusoidal excitation. Torque ripple and speed ripple are investigated based on hysteresis current control. Constant and sinusoidal current references are considered for comparison in both DC and AC excitation. Extensive theoretical and experimental investigations are made to bring out the merits and demerits of AC versus DC excitation. It is shown that the constructionally simple SRM can be favorably controlled with simple R dump converter with direct AC excitation without need for DC link capacitor. A 4-phase 8/6 0.5 kW SRM is used for experimentation. PMID:25642452

  3. Experimental evaluation of LED-based solar blind NLOS communication links.

    Science.gov (United States)

    Chen, Gang; Abou-Galala, Feras; Xu, Zhengyuan; Sadler, Brian M

    2008-09-15

    Experimental results are reported demonstrating non-line of sight short-range ultraviolet communication link losses, and performance of photon counting detectors, operating in the solar blind spectrum regime. We employ light emitting diodes with divergent beams, a solar blind filter, and a wide field-of-view detector. Signal and noise statistics are characterized, and receiver performance is demonstrated. The effects of transmitter and receiver elevation angles, separation distance, and path loss are included.

  4. Experimental research on English vowel errors analysis

    OpenAIRE

    Huang Qiuhua

    2016-01-01

    Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software. Then we summarized phonetic pronunciation errors of college students through the analysis of English pronunciation of vowels, we found that college students’ English pronunciation are easy occur tongue position and lip shape errors during pronounce vow...

  5. Etude théorique et expérimentale de la liaison de deux puits par fracturation hydraulique Theoretical and Experimental Analysis of the Linking of Two Wells by Hydraulic Fracturing

    Directory of Open Access Journals (Sweden)

    Bouteca M.

    2006-11-01

    Full Text Available La nécessité de réaliser, dans une couche mince et située à plus de 1000 m de profondeur, une communication hydraulique ou pneumatique entre deux sondages verticaux, a conduit à l'étude d'une méthode basée sur la fracturation hydraulique des puits à relier. Une telle approche suppose que l'on connaisse ou que l'on contrôle la direction des fractures développées. Les techniques actuelles ne permettant pas d'apprécier la direction de fracture avec une précision suffisante, la méthode proposée vise à influencer favorablement cette direction. Elle est basée sur une modification des contraintes effectives en place par une injection préalable de fluide dans les puits à relier. Les résultats obtenus au moyen de calculs analytiques et numériques à deux dimensions sont présentés, ainsi que les expériences réalisées sur un modèle physique en laboratoire. In a thin layer and at a depth of more than 1000 meters, the need to create a hydraulic or pneumatic communication between two vertical boreholes led to research on a method based on hydraulic fracturing in the wells to be linked. Such an approach supposes that the direction of the fractures thus created must be known or controlled. Current techniques cannot be used to assess fracture direction with sufficient accuracy. The method proposed here aims to have a favorable influence on this direction. It is based on making a change in the effective stresses in situ by the prior injection of fluid into the wells to be linked. The results obtained by two-dimensional analytical and digital computing are described together with the experiments performed on a physical model in the laboratory.

  6. Experimental scleral cross-linking increases glaucoma damage in a mouse model.

    Science.gov (United States)

    Kimball, Elizabeth C; Nguyen, Cathy; Steinhart, Matthew R; Nguyen, Thao D; Pease, Mary E; Oglesby, Ericka N; Oveson, Brian C; Quigley, Harry A

    2014-11-01

    The purpose of this study was to assess the effect of a scleral cross-linking agent on susceptibility to glaucoma damage in a mouse model.CD1 mice underwent 3 subconjunctival injections of 0.5 M glyceraldehyde (GA) in 1 week, then had elevated intraocular pressure (IOP) induced by bead injection. Degree of cross-linking was measured by enzyme-linked immunosorbent assay (ELISA), scleral permeability was measured by fluorescence recovery after photobleaching (FRAP), and the mechanical effects of GA exposure were measured by inflation testing. Control mice had buffer injection or no injection in 2 separate glaucoma experiments. IOP was monitored by Tonolab and retinal ganglion cell (RGC) loss was measured by histological axon counting. To rule out undesirable effects of GA, we performed electroretinography and detailed histology of the retina. GA exposure had no detectable effects on RGC number, retinal structure or function either histologically or electrophysiologically. GA increased cross-linking of sclera by 37% in an ELISA assay, decreased scleral permeability (FRAP, p = 0.001), and produced a steeper pressure-strain behavior by in vitro inflation testing. In two experimental glaucoma experiments, GA-treated eyes had greater RGC axon loss from elevated IOP than either buffer-injected or control eyes, controlling for level of IOP exposure over time (p = 0.01, and 0.049, multivariable regression analyses). This is the first report that experimental alteration of the sclera, by cross-linking, increases susceptibility to RGC damage in mice. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Linking Ayurveda and Western medicine by integrative analysis

    Directory of Open Access Journals (Sweden)

    Fazlin Mohd Fauzi

    2013-01-01

    Full Text Available In this article, we discuss our recent work in elucidating the mode-of-action of compounds used in traditional medicine including Ayurvedic medicine. Using computational (′in silico′ approach, we predict potential targets for Ayurvedic anti-cancer compounds, obtained from the Indian Plant Anticancer Database given its chemical structure. In our analysis, we observed that: (i the targets predicted can be connected to cancer pathogenesis i.e. steroid-5-alpha reductase 1 and 2 and estrogen receptor-β, and (ii predominantly hormone-dependent cancer targets were predicted for the anti-cancer compounds. Through the use of our in silico target prediction, we conclude that understanding how traditional medicine such as Ayurveda work through linking with the ′western′ understanding of chemistry and protein targets can be a fruitful avenue in addition to bridging the gap between the two different schools of thinking. Given that compounds used in Ayurveda have been tested and used for thousands of years (although not in the same approach as Western medicine, they can potentially be developed into potential new drugs. Hence, to further advance the case of Ayurvedic medicine, we put forward some suggestions namely: (a employing and integrating novel analytical methods given the advancements of ′omics′ and (b sharing experimental data and clinical results on studies done on Ayurvedic compounds in an easy and accessible way.

  8. Experimental research on English vowel errors analysis

    Directory of Open Access Journals (Sweden)

    Huang Qiuhua

    2016-01-01

    Full Text Available Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software. Then we summarized phonetic pronunciation errors of college students through the analysis of English pronunciation of vowels, we found that college students’ English pronunciation are easy occur tongue position and lip shape errors during pronounce vowels. Based on analysis of pronunciation errors, we put forward targeted voice training for college students’ English pronunciation, eventually increased the students learning interest, and improved the teaching of English phonetics.

  9. An experimental study on digital predistortion for radio-over-fiber links

    Science.gov (United States)

    Vieira, Luis C.; Gomes, Nathan J.; Nkansah, Anthony

    2010-12-01

    Radio-over-fiber (RoF) has been proposed as an enabling technology for broadband networks, such as WiMAX and WiFi. Besides the inherent high bandwidth and reliability of RoF systems, they also allow the reduction of installation and maintenance cost of the remote antenna units (RAUs) and improvement in the coverage area of the base station/access point. However, the nonlinear distortion of the optical link, which stems mainly from the laser diode, may impose serious limitations on the system performance, especially when high PAPR, wideband signals are used. Thus, distortion compensation is a key issue in order to facilitate the application of the RoF technology for broadband networks. In this work, digital predistortion for directly modulated RoF links is experimentally investigated. A memory-polynomial- based predistorter model is identified from measurements of the baseband OFDM input-output signals and through the use of an indirect learning architecture. Then, a predistorted signal is generated and fed to the RoF link for comparing its output with that of the non-predistorted one. As a result of this compensation technique, an improvement of the static link linearity and the output constellation diagram has been found, with an EVM reduction of 1.73 %.

  10. Development of OFDM based Secondary Link: Some Experimental Results on USRP N210 Platform

    Directory of Open Access Journals (Sweden)

    M. Janjić

    2014-06-01

    Full Text Available Some experimental results of the concept development and practical implementation of an Orthogonal Frequency Division Multiplexing (OFDM based secondary cognitive link are presented in this paper. The secondary link is realized using Universal Software Radio Peripheral (USRP N210 platforms. For communication with USRP, we use MATLAB toolbox. Several algorithms are used to overcome transmission problems. Time-synchronization is achieved using a method based on auto-correlation of two sliding windows. Frequency offset estimation is performed using a phase offset between samples in a signal header, comprised of a sinusoid. A channel is estimated using predefined symbols inserted at the beginning of every frame, which enables channel equalization. Also, the cognitive feature of spectrum sensing and changing transmission parameters is implemented. A least-mean-square adaptive filter is introduced to offer time-synchronization error estimation as well as an alternative option for channel equalization.

  11. Experimental and numerical analysis of convergent nozzlex

    Science.gov (United States)

    Srinivas, G.; Rakham, Bhupal

    2017-05-01

    In this paper the main focus was given to convergent nozzle where both the experimental and numerical calculations were carried out with the support of standardized literature. In the recent years the field of air breathing and non-air breathing engine developments significantly increase its performance. To enhance the performance of both the type of engines the nozzle is the one of the component which will play a vital role, especially selecting the type of nozzle depends upon the vehicle speed requirement and aerodynamic behavior at most important in the field of propulsion. The convergent nozzle flow experimental analysis done using scaled apparatus and the similar setup was arranged artificially in the ANSYS software for doing the flow analysis across the convergent nozzle. The consistent calculation analysis are done based on the public literature survey to validate the experimental and numerical simulation results of convergent nozzle. Using these two experimental and numerical simulation approaches the best fit results will bring up to meet the design requirements. However the comparison also made to meet the reliability of the work on design criteria of convergent nozzle which can entrench in the field of propulsion applications.

  12. Feasibility analysis of WDM links for radar applications

    Directory of Open Access Journals (Sweden)

    D. Meena

    2015-03-01

    Full Text Available Active phased array antennas enhances the performance of modern radars by using multiple low power transmit/receive modules in place of a high power transmitter in conventional radars. Fully distributed phased array radars demand the distribution of various signals in radio frequency (RF and digital domain for real time operation. This is normally achieved through complex and bulky coaxial distribution networks. In this work, we intend to tap the inherent advantages of fiber links with wavelength division multiplexed (WDM technology and a feasibility study to adapt these links for radar applications is carried out. This is done by analysing various parameters like amplitude, delay, frequency and phase variation response of various radar waveforms over WDM links. This also includes performance evaluation of non-linear frequency modulation (NLFM signals, known for better signal to noise ratio (SNR to specific side lobe levels. NLFM waveforms are further analysed using pulse compression (PC technique. Link evaluation is also carried out using a standard simulation environment and is then experimentally verified with other waveforms like RF continuous wave (CW, pulsed RF and digital signals. Synchronization signals are generated from this variable duty cycle digital signals during real time radar operation. During evaluation of digital signals, variable transient effects for different duty cycles are observed from an amplifier configuration. A suppression method is proposed to eliminate this transient effects. Further, the link delay response is investigated using different lengths of fiber spools. It can be inferred from the experimental results that WDM links are capable of handling various signals significant to radar applications.

  13. Experimental Evaluation of Impairments in Unrepeatered DP-16QAM Link with Distributed Raman Amplification

    Directory of Open Access Journals (Sweden)

    Xiaodan Pang

    2017-03-01

    Full Text Available The transmission impairments of a Raman amplified link using dual-polarization 16-quadrature amplitude modulation (DP-16QAM are experimentally characterized. The impact of amplitude and phase noise on the signal due to relative intensity noise (RIN transfer from the pump are compared for two pumping configurations: first-order backward pumping and bi-directional pumping. Experimental results indicate that with increased Raman backward pump power, though the optical signal-to-noise ratio (OSNR is increased, so is the pump-induced amplitude and phase noise. The transmission performance is firstly improved by the enhanced OSNR at a low pump power until an optimum point is reached, and then the impairments due to pump-induced noise start to dominate. However, the introduction of a low pump power in the forward direction can further improve the system’s performance.

  14. Experimental Performance Analysis of Wireless Links for Healthcare ...

    African Journals Online (AJOL)

    . ... Malawi Journal of Science and Technology ... The results show that the use of wireless networking in healthcare application will be limited by packet loss, delay and jitter when the number of hops involved in the transmission of information ...

  15. Experimental Performance Analysis of Wireless Links for Healthcare ...

    African Journals Online (AJOL)

    Malawi Journal of Science and Technology. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 9, No 1 (2009) >. Log in or Register to get access to full text downloads.

  16. Dynamic Analysis and Control of Lightweight Manipulators with Flexible Parallel Link Mechanisms. Ph.D. Thesis

    Science.gov (United States)

    Lee, Jeh Won

    1990-01-01

    The objective is the theoretical analysis and the experimental verification of dynamics and control of a two link flexible manipulator with a flexible parallel link mechanism. Nonlinear equations of motion of the lightweight manipulator are derived by the Lagrangian method in symbolic form to better understand the structure of the dynamic model. The resulting equation of motion have a structure which is useful to reduce the number of terms calculated, to check correctness, or to extend the model to higher order. A manipulator with a flexible parallel link mechanism is a constrained dynamic system whose equations are sensitive to numerical integration error. This constrained system is solved using singular value decomposition of the constraint Jacobian matrix. Elastic motion is expressed by the assumed mode method. Mode shape functions of each link are chosen using the load interfaced component mode synthesis. The discrepancies between the analytical model and the experiment are explained using a simplified and a detailed finite element model.

  17. The Aeronautical Data Link: Decision Framework for Architecture Analysis

    Science.gov (United States)

    Morris, A. Terry; Goode, Plesent W.

    2003-01-01

    A decision analytic approach that develops optimal data link architecture configuration and behavior to meet multiple conflicting objectives of concurrent and different airspace operations functions has previously been developed. The approach, premised on a formal taxonomic classification that correlates data link performance with operations requirements, information requirements, and implementing technologies, provides a coherent methodology for data link architectural analysis from top-down and bottom-up perspectives. This paper follows the previous research by providing more specific approaches for mapping and transitioning between the lower levels of the decision framework. The goal of the architectural analysis methodology is to assess the impact of specific architecture configurations and behaviors on the efficiency, capacity, and safety of operations. This necessarily involves understanding the various capabilities, system level performance issues and performance and interface concepts related to the conceptual purpose of the architecture and to the underlying data link technologies. Efficient and goal-directed data link architectural network configuration is conditioned on quantifying the risks and uncertainties associated with complex structural interface decisions. Deterministic and stochastic optimal design approaches will be discussed that maximize the effectiveness of architectural designs.

  18. Leader Positivity and Follower Creativity: An Experimental Analysis

    Science.gov (United States)

    Avey, James B.; Richmond, F. Lynn; Nixon, Don R.

    2012-01-01

    Using an experimental research design, 191 working adults were randomly assigned to two experimental conditions in order to test a theoretical model linking leader and follower positive psychological capital (PsyCap). Multiple methods were used to gather information from the participants. We found when leader PsyCap was manipulated experimentally,…

  19. A System Design and Analysis for Satellite Communication Link

    Directory of Open Access Journals (Sweden)

    Tae Jin Chung

    2000-12-01

    Full Text Available A satellite RF communication link is analyzed based on a simple fundamental equations by systematic approach in this paper. The number of variables related to a design and analysis of satellite RF link is often a dozen or more, thus it is a tedious and time-consuming task. With the given input data, the important parameters are calculated step by step and three communication characteristics such as communication channel capacity, carrier-to-noise ratio (CNR at the satellite and ground station are analyzed. It gives very useful information to the system engineers for designing and analyzing the overall satellite communication system in the conceptual design phase.

  20. Network worlds : from link analysis to virtual places.

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, C. (Cliff)

    2002-01-01

    Significant progress is being made in knowledge systems through recent advances in the science of very large networks. Attention is now turning in many quarters to the potential impact on counter-terrorism methods. After reviewing some of these advances, we will discuss the difference between such 'network analytic' approaches, which focus on large, homogeneous graph strucures, and what we are calling 'link analytic' approaches, which focus on somewhat smaller graphs with heterogeneous link types. We use this venue to begin the process of rigorously defining link analysis methods, especially the concept of chaining of views of multidimensional databases. We conclude with some speculation on potential connections to virtual world architectures.

  1. [Experimental realization of minimally invasive techniques of scleral collagen cross-linking].

    Science.gov (United States)

    Iomdina, Е N; Tarutta, Е P; Semchishen, V А; Korigodskiy, А R; Zakharov, I D; Khoroshilova-Maslova, I P; Ignat'eva, N Yu; Kiseleva, Т N; Sianosyan, А А; Milash, S V

    effect. The findings also include: a 1.8 times higher rate of scleral cross-linking, activation of cellular elements, neoformation of connective tissue on the scleral surface, and vascular growth, which together indicate a pronounced metabolic and strengthening effect of Sklerateks on the sclera. Experimental results on minimally invasive techniques of SXL allow to recommend them for further clinical investigation as a promising treatment of progressive myopia.

  2. Analytical and experimental analysis of magnetorheological elastomers

    Science.gov (United States)

    Trabia, Sarah

    Many engineering applications ranging from robotic joints to shock and vibration mitigation can benefit by incorporating components with variable stiffness. In addition, variable stiffness structures can provide haptic feedback (the sense of touch) to the user. In this work, it is proposed to study Magnetorheological Elastomers (MRE), where iron particles within the elastomer compound develop a dipole interaction energy, to be used in a device for haptic feedback. A novel feature of this MRE device is to introduce a field-induced variable shear modulus bias via a permanent magnet and using a current input to the electromagnetic control coil to change the modulus of the elastomer in both directions (softer or harder). In this preliminary work, both computational and experimental results of the proposed MRE design are presented. The design is created in COMSOL to verify that the magnetic field is in the desired direction. MRE was fabricated and characterized using a Bose Dynamic Mechanical Analyzer for the shear modulus. Using this information, it is possible to know how the MRE will react in magnetic fields within the haptic feedback device. Additionally, a model for an MRE is developed in a multi-physics COMSOL program that is linked to a MATLAB function that predicts the shear modulus and incorporates it into the material properties to best simulate the MRE's ability to change shear modulus.

  3. Experimental Characterization of LTE Wireless Links in High-Speed Trains

    Directory of Open Access Journals (Sweden)

    Tomás Domínguez-Bolaño

    2017-01-01

    Full Text Available Multimedia and data-based services experienced a nonstopping growth over the last few years. People are continuously on the move using devices to access multimedia contents or other data-based services. Due to this, railway companies are showing a great interest in deploying broadband mobile wireless networks in high-speed-trains with the aim of supporting both passenger services provisioning as well as automatic train control and signaling. Nowadays, the most widely used technology for communications between trains and the railway infrastructure is GSM for Railways (GSM-R; however, it has limited capabilities to support such advanced services. Due to its success in the mass market, Long Term Evolution (LTE seems to be the best candidate to substitute GSM-R. In this paper, we experimentally characterize the downlink between an LTE Evolved NodeB (eNodeB and a high-speed train in a commercial high-speed line. We consider two links: the one between the eNodeB and the antennas placed outdoors on the train roof, and the direct link between the eNodeB and a receiver inside the train. Such a characterization consists in assessing the path loss, the Signal to Noise Ratio, the K-Factor, the Power Delay Profile, the delay spread, and the Doppler Power Spectral Density.

  4. Unsupervised Action Classification Using Space-Time Link Analysis

    Directory of Open Access Journals (Sweden)

    Feris Rogerio

    2010-01-01

    Full Text Available We address the problem of unsupervised discovery of action classes in video data. Different from all existing methods thus far proposed for this task, we present a space-time link analysis approach which consistently matches or exceeds the performance of traditional unsupervised action categorization methods in various datasets. Our method is inspired by the recent success of link analysis techniques in the image domain. By applying these techniques in the space-time domain, we are able to naturally take into account the spatiotemporal relationships between the video features, while leveraging the power of graph matching for action classification. We present a comprehensive set of experiments demonstrating that our approach is capable of handling cluttered backgrounds, activities with subtle movements, and video data from moving cameras. State-of-the-art results are reported on standard datasets. We also demonstrate our method in a compelling surveillance application with the goal of avoiding fraud in retail stores.

  5. Unsupervised action classification using space-time link analysis

    DEFF Research Database (Denmark)

    Liu, Haowei; Feris, Rogerio; Krüger, Volker

    2010-01-01

    In this paper we address the problem of unsupervised discovery of action classes in video data. Different from all existing methods thus far proposed for this task, we present a space-time link analysis approach which matches the performance of traditional unsupervised action categorization methods...... in a standard dataset. Our method is inspired by the recent success of link analysis techniques in the image domain. By applying these techniques in the space-time domain, we are able to naturally take into account the spatio-temporal relationships between the video features, while leveraging the power of graph...... matching for action classification. We present an experiment to demonstrate that our approach is capable of handling cluttered backgrounds, activities with subtle movements, and video data from moving cameras....

  6. Protein functional links in Trypanosoma brucei, identified by gene fusion analysis

    Directory of Open Access Journals (Sweden)

    Trimpalis Philip

    2011-07-01

    Full Text Available Abstract Background Domain or gene fusion analysis is a bioinformatics method for detecting gene fusions in one organism by comparing its genome to that of other organisms. The occurrence of gene fusions suggests that the two original genes that participated in the fusion are functionally linked, i.e. their gene products interact either as part of a multi-subunit protein complex, or in a metabolic pathway. Gene fusion analysis has been used to identify protein functional links in prokaryotes as well as in eukaryotic model organisms, such as yeast and Drosophila. Results In this study we have extended this approach to include a number of recently sequenced protists, four of which are pathogenic, to identify fusion linked proteins in Trypanosoma brucei, the causative agent of African sleeping sickness. We have also examined the evolution of the gene fusion events identified, to determine whether they can be attributed to fusion or fission, by looking at the conservation of the fused genes and of the individual component genes across the major eukaryotic and prokaryotic lineages. We find relatively limited occurrence of gene fusions/fissions within the protist lineages examined. Our results point to two trypanosome-specific gene fissions, which have recently been experimentally confirmed, one fusion involving proteins involved in the same metabolic pathway, as well as two novel putative functional links between fusion-linked protein pairs. Conclusions This is the first study of protein functional links in T. brucei identified by gene fusion analysis. We have used strict thresholds and only discuss results which are highly likely to be genuine and which either have already been or can be experimentally verified. We discuss the possible impact of the identification of these novel putative protein-protein interactions, to the development of new trypanosome therapeutic drugs.

  7. Bibliometric analysis of scientific production about Linked Data

    Directory of Open Access Journals (Sweden)

    Leandro Dal Pizzol

    2015-09-01

    Full Text Available Introduction: Since Tim Berners-Lee coined the term Linked Data in 2006, many studies have emerged based on this initiative. Whether in the form of information access initiatives, whether in applications based on this data type, the interest in this new way to publish and consume information on the Web is increasingly in focus. Objective: In this paper, we present a bibliometric review with the aim of contributing to a better understanding and clarification of concepts and terms associated with the area of Linked Data. Methodology: We have used the Web of Science (WoS, Scopus, EBSCO and IEEE scientific databases, in order to find the existing studies about Linked Data until October 2012. Results: We have mapped 148 scientific papers that address the above issue, written by 409 authors from 160 institutions from 30 different countries. Through the analysis of the articles, it was found that researches about Linked Data are concentrated in a small authors group, suggesting future research opportunities. Conclusions: Synthesizing the information related to the scientific publications in a given area allows building a theoretical background that supports the development of future researches.

  8. Immunoinformatics Features Linked to Leishmania Vaccine Development: Data Integration of Experimental and In Silico Studies.

    Science.gov (United States)

    Brito, Rory C F; Guimarães, Frederico G; Velloso, João P L; Corrêa-Oliveira, Rodrigo; Ruiz, Jeronimo C; Reis, Alexandre B; Resende, Daniela M

    2017-02-10

    Leishmaniasis is a wide-spectrum disease caused by parasites from Leishmania genus. There is no human vaccine available and it is considered by many studies as apotential effective tool for disease control. To discover novel antigens, computational programs have been used in reverse vaccinology strategies. In this work, we developed a validation antigen approach that integrates prediction of B and T cell epitopes, analysis of Protein-Protein Interaction (PPI) networks and metabolic pathways. We selected twenty candidate proteins from Leishmania tested in murine model, with experimental outcome published in the literature. The predictions for CD4⁺ and CD8⁺ T cell epitopes were correlated with protection in experimental outcomes. We also mapped immunogenic proteins on PPI networks in order to find Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with them. Our results suggest that non-protective antigens have lowest frequency of predicted T CD4⁺ and T CD8⁺ epitopes, compared with protective ones. T CD4⁺ and T CD8⁺ cells are more related to leishmaniasis protection in experimental outcomes than B cell predicted epitopes. Considering KEGG analysis, the proteins considered protective are connected to nodes with few pathways, including those associated with ribosome biosynthesis and purine metabolism.

  9. Input Harmonic Analysis on the Slim DC-Link Drive Using Harmonic State Space Model

    DEFF Research Database (Denmark)

    Yang, Feng; Kwon, Jun Bum; Wang, Xiongfei

    2017-01-01

    variation according to the switching instant, the harmonics at the steady-state condition, as well as the coupling between the multiple harmonic impedances. By using this model, the impaction on the harmonics performance by the film capacitor and the grid inductance is derived. Simulation and experimental......The harmonic performance of the slim dc-link adjustable speed drives has shown good performance in some studies but poor in some others. The contradiction indicates that a feasible theoretical analysis is still lacking to characterize the harmonic distortion for the slim dc-link drive. Considering...... the shortcomings of the present harmonic analysis methods, such as the time-domain simulation, or the Fourier analysis, this paper proposes a Harmonic State Space model to study the harmonics performance for this type of drive. In this study, this model is utilized to describe the behavior of the harmonic...

  10. Second-generation method for analysis of chromatin binding with formaldehyde-cross-linking kinetics.

    Science.gov (United States)

    Zaidi, Hussain; Hoffman, Elizabeth A; Shetty, Savera J; Bekiranov, Stefan; Auble, David T

    2017-11-24

    Formaldehyde-cross-linking underpins many of the most commonly used experimental approaches in the chromatin field, especially in capturing site-specific protein-DNA interactions. Extending such assays to assess the stability and binding kinetics of protein-DNA interactions is more challenging, requiring absolute measurements with a relatively high degree of physical precision. We previously described an experimental framework called the cross-linking kinetics (CLK) assay, which uses time-dependent formaldehyde-cross-linking data to extract kinetic parameters of chromatin binding. Many aspects of formaldehyde behavior in cells are unknown or undocumented, however, and could potentially affect CLK data analyses. Here, we report biochemical results that better define the properties of formaldehyde-cross-linking in budding yeast cells. These results have the potential to inform interpretations of "standard" chromatin assays, including chromatin immunoprecipitation. Moreover, the chemical complexity we uncovered resulted in the development of an improved method for measuring binding kinetics with the CLK approach. Optimum conditions included an increased formaldehyde concentration and more robust glycine-quench conditions. Notably, we observed that formaldehyde-cross-linking rates can vary dramatically for different protein-DNA interactions in vivo Some interactions were cross-linked much faster than the in vivo macromolecular interactions, making them suitable for kinetic analysis. For other interactions, we found the cross-linking reaction occurred on the same time scale or slower than binding dynamics; for these interactions, it was sometimes possible to compute the in vivo equilibrium-binding constant but not binding on- and off-rates. This improved method yields more accurate in vivo binding kinetics estimates on the minute time scale. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs.

    Science.gov (United States)

    Venkova, Larisa; Aliper, Alexander; Suntsova, Maria; Kholodenko, Roman; Shepelin, Denis; Borisov, Nicolas; Malakhova, Galina; Vasilov, Raif; Roumiantsev, Sergey; Zhavoronkov, Alex; Buzdin, Anton

    2015-09-29

    Effective choice of anticancer drugs is important problem of modern medicine. We developed a method termed OncoFinder for the analysis of new type of biomarkers reflecting activation of intracellular signaling and metabolic molecular pathways. These biomarkers may be linked with the sensitivity to anticancer drugs. In this study, we compared the experimental data obtained in our laboratory and in the Genomics of Drug Sensitivity in Cancer (GDS) project for testing response to anticancer drugs and transcriptomes of various human cell lines. The microarray-based profiling of transcriptomes was performed for the cell lines before the addition of drugs to the medium, and experimental growth inhibition curves were built for each drug, featuring characteristic IC50 values. We assayed here four target drugs - Pazopanib, Sorafenib, Sunitinib and Temsirolimus, and 238 different cell lines, of which 11 were profiled in our laboratory and 227 - in GDS project. Using the OncoFinder-processed transcriptomic data on ~600 molecular pathways, we identified pathways showing significant correlation between pathway activation strength (PAS) and IC50 values for these drugs. Correlations reflect relationships between response to drug and pathway activation features. We intersected the results and found molecular pathways significantly correlated in both our assay and GDS project. For most of these pathways, we generated molecular models of their interaction with known molecular target(s) of the respective drugs. For the first time, our study uncovered mechanisms underlying cancer cell response to drugs at the high-throughput molecular interactomic level.

  12. Analysis of the interaction between experimental and applied behavior analysis.

    Science.gov (United States)

    Virues-Ortega, Javier; Hurtado-Parrado, Camilo; Cox, Alison D; Pear, Joseph J

    2014-01-01

    To study the influences between basic and applied research in behavior analysis, we analyzed the coauthorship interactions of authors who published in JABA and JEAB from 1980 to 2010. We paid particular attention to authors who published in both JABA and JEAB (dual authors) as potential agents of cross-field interactions. We present a comprehensive analysis of dual authors' coauthorship interactions using social networks methodology and key word analysis. The number of dual authors more than doubled (26 to 67) and their productivity tripled (7% to 26% of JABA and JEAB articles) between 1980 and 2010. Dual authors stood out in terms of number of collaborators, number of publications, and ability to interact with multiple groups within the field. The steady increase in JEAB and JABA interactions through coauthors and the increasing range of topics covered by dual authors provide a basis for optimism regarding the progressive integration of basic and applied behavior analysis. © Society for the Experimental Analysis of Behavior.

  13. Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells.

    Science.gov (United States)

    Aricha, Revital; Feferman, Tali; Berrih-Aknin, Sonia; Fuchs, Sara; Souroujon, Miriam C

    2012-12-01

    Aire (autoimmune regulator) has a key role in the establishment of tolerance to autoantigens. Aire(-/-) mice present decreased thymic expression of AChR, significantly lower frequencies of regulatory T (T(reg)) cells, and higher expression of Th17 markers, compared to controls. We therefore predicted that Aire(-/-) mice would be more susceptible to induction of experimental autoimmune myasthenia gravis (EAMG). However, when EAMG was induced in young mice, Aire(-/-) mice presented a milder disease that wild-type (WT) controls. In contrast, when EAMG was induced in older mice, Aire(-/-) mice were more severely affected than WT mice. The relative resistance to EAMG in young Aire(-/-) mice correlated with increased numbers of T(reg) cells in their spleens compared to young controls. A similar age-related susceptibility was also observed when EAE was induced in Aire(-/-) mice, suggesting an age-related link among Aire, disease susceptibility, and peripheral T(reg) cells that may be a general feature of autoimmunity. © 2012 New York Academy of Sciences.

  14. Analysis of Links Positions in Landing Gear Mechanism

    Science.gov (United States)

    Brewczyński, D.; Tora, G.

    2014-08-01

    This article contains a kinematic analysis of an aircraft chassis mechanism in a range of positions. The mechanism of the chassis is made up of several smaller subsystems with different functions. The first mechanism is used to eject the chassis before landing (touchdown) and fold it to hatchway after the lift off. The second mechanism is designed to perform rotation of the crossover with the wheel, in order to adjust the position of the wheel to fit it in the limited space in the hold. The third mechanism allows movement of the chassis resulting from the change in length of the damper. To determine the position of the following links of the mechanism calculus of vectors was applied in which unit vectors were used to represent the angular position of the links. The aim of the analysis is to determine the angle of convergence and the angle of heel wheels as a function of the variable length of hydraulic cylinder, length of the shock absorber, length of the regulations rods

  15. Genetic analysis of experimental allergic encephalomyelitis in mice

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.; Rosenwasser, O.A.; O`Neill, J.K.; Turk, J.L. [Royal College of Surgeons of England, London (United Kingdom)

    1995-10-15

    Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system that exhibits many pathologic similarities with multiple sclerosis. While products of the MHC are known to control the development of EAE, it is clear that non-MHC products also influence susceptibility. The chromosomal locations of these were investigated in selective crosses between MHC class II-compatible, EAE-susceptible Biozzi ABH, and low responder nonobese diabetic (NOD) mice. The disease was dominant and highly influenced by gender in the backcross one (BC{sub 1}) generation. Female mice were significantly more susceptible than male mice. Segregation of disease frequency of female animals in this cross suggested that EAE was controlled by a major locus. Although microsatellite-based exclusion mapping indicated that a number of regions on chromosomes 5, 6, 7, 8, 9, 10, 11, 12, 13, and 18 showed evidence of linkage (p<0.05) compared with expected random distributions of alleles, disease susceptibility was most strongly linked (p<0.05) to chromosome 7. However, by selectively analyzing animals that were either severely affected or almost normal, additional susceptibility loci were mapped on chromosomes 18 and 11 that were linked (p<0.001) to resistance and the development of severe disease, respectively. The data indicate a major locus on chromosome 7, affecting initiation and severity of EAE that is probably modified by several other unlinked loci. These localizations may provide candidate loci for the analysis of human autoimmune-demyelinating disease. 30 refs., 5 tabs.

  16. The Role of the Media in Body Image Concerns among Women: A Meta-Analysis of Experimental and Correlational Studies

    Science.gov (United States)

    Grabe, Shelly; Ward, L. Monique; Hyde, Janet Shibley

    2008-01-01

    Research suggests that exposure to mass media depicting the thin-ideal body may be linked to body image disturbance in women. This meta-analysis examined experimental and correlational studies testing the links between media exposure to women's body dissatisfaction, internalization of the thin ideal, and eating behaviors and beliefs with a sample…

  17. Microwave links for rainfall estimation in urban environment: insights from an experimental setup in Luxembourg city

    NARCIS (Netherlands)

    Fenicia, F.; Pfister, L.; Kavetski, D.; Matgen, P.; Iffly, J.F.; Hoffman, L.; Uijlenhoet, R.

    2012-01-01

    Although the theoretical aspects of rainfall monitoring through microwave links are quite well established, only few practical applications have evaluated this technique in an operational setting. Microwave links are of particular interest in urban areas, where high frequency measurements are needed

  18. Design and Analysis of Underwater Acoustic Networks with Reflected Links

    Science.gov (United States)

    Emokpae, Lloyd

    -of-sight (LOS) and NLOS links by utilizing directional antennas, which will boost the signal-to-noise ratio (SNR) at the receiver while promoting NLOS usage. In our model, we employ a directional underwater acoustic antenna composed of an array of hydrophones that can be summed up at various phases and amplitudes resulting in a beam-former. We have also adopted a practical multimodal directional transducer concept which generates both directional and omni-directional beam patterns by combining the fundamental vibration modes of a cylindrical acoustic radiator. This allows the transducer to be electrically controlled and steered by simply adjusting the electrical voltage weights. A prototype acoustic modem is then developed to utilize the multimodal directional transducer for both LOS and NLOS communication. The acoustic modem has also been used as a platform for empirically validating our SBR communication model in a tank and with empirical data. Networking protocols have been developed to exploit the SBR communication model. These protocols include node discovery and localization, directional medium access control (D-MAC) and geographical routing. In node discovery and localization, each node will utilize SBR-based range measurements to its neighbors to determine their relative position. The D-MAC protocol utilizes directional antennas to increase the network throughput due to the spatial efficiency of the antenna model. In the proposed reflection-enabled directional MAC protocol (RED-MAC), each source node will be able to determine if an obstacle is blocking the LOS link to the destination and switch to the best NLOS link by utilizing surface/bottom reflections. Finally, we have developed a geographical routing algorithm which aims to establish the best stable route from a source node to a destination node. The optimized route is selected to achieve maximum network throughput. Extensive analysis of the network throughput when utilizing directional antennas is also presented

  19. Linked independent component analysis for multimodal data fusion.

    Science.gov (United States)

    Groves, Adrian R; Beckmann, Christian F; Smith, Steve M; Woolrich, Mark W

    2011-02-01

    In recent years, neuroimaging studies have increasingly been acquiring multiple modalities of data and searching for task- or disease-related changes in each modality separately. A major challenge in analysis is to find systematic approaches for fusing these differing data types together to automatically find patterns of related changes across multiple modalities, when they exist. Independent Component Analysis (ICA) is a popular unsupervised learning method that can be used to find the modes of variation in neuroimaging data across a group of subjects. When multimodal data is acquired for the subjects, ICA is typically performed separately on each modality, leading to incompatible decompositions across modalities. Using a modular Bayesian framework, we develop a novel "Linked ICA" model for simultaneously modelling and discovering common features across multiple modalities, which can potentially have completely different units, signal- and contrast-to-noise ratios, voxel counts, spatial smoothnesses and intensity distributions. Furthermore, this general model can be configured to allow tensor ICA or spatially-concatenated ICA decompositions, or a combination of both at the same time. Linked ICA automatically determines the optimal weighting of each modality, and also can detect single-modality structured components when present. This is a fully probabilistic approach, implemented using Variational Bayes. We evaluate the method on simulated multimodal data sets, as well as on a real data set of Alzheimer's patients and age-matched controls that combines two very different types of structural MRI data: morphological data (grey matter density) and diffusion data (fractional anisotropy, mean diffusivity, and tensor mode). Copyright © 2010 Elsevier Inc. All rights reserved.

  20. General aviation data link survey analysis : National Business Aircraft Association

    Science.gov (United States)

    1996-05-01

    The Federal Aviation Administration (FAA) is interested in integrating Data Link communications technology into the General Aviation (GA) community. But, how much does the GA community know about the Data Link concept, the services that are possible,...

  1. Experimental measurements and noise analysis of a cryogenic radiometer

    Energy Technology Data Exchange (ETDEWEB)

    Carr, S. M.; Woods, S. I.; Jung, T. M.; Carter, A. C.; Datla, R. U. [National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, Maryland 20899 (United States)

    2014-07-15

    A cryogenic radiometer device, intended for use as part of an electrical-substitution radiometer, was measured at low temperature. The device consists of a receiver cavity mechanically and thermally connected to a temperature-controlled stage through a thin-walled polyimide tube which serves as a weak thermal link. With the temperature difference between the receiver and the stage measured in millikelvin and the electrical power measured in picowatts, the measured responsivity was 4700 K/mW and the measured thermal time constant was 14 s at a stage temperature of 1.885 K. Noise analysis in terms of Noise Equivalent Power (NEP) was used to quantify the various fundamental and technical noise contributions, including phonon noise and Johnson-Nyquist noise. The noise analysis clarifies the path toward a cryogenic radiometer with a noise floor limited by fundamental phonon noise, where the magnitude of the phonon NEP is 6.5 fW/√(Hz) for the measured experimental parameters.

  2. Hybrid Experimental-Numerical Stress Analysis.

    Science.gov (United States)

    1983-04-01

    A. 1. and Riley# W. F., Introduction to Pho hanics, Pren- tics -Hall, Englewood Cliffs# 1965P pp. 185-186. 8. Rao, G. V., "Experimental-numerical...Naw1 o a. CA *924 Loe Amnl*&. Ca 10024 Profesor T. V. Cosng Or. IF. Sm#Amv Or. M. P. gtesProfeesr Ulert pried University of Agree on"ser si pmlo

  3. Analysis of Azari Language based on Parsing using Link Gram

    Directory of Open Access Journals (Sweden)

    Maryam Arabzadeh

    2014-09-01

    Full Text Available There are different classes of theories for the natural lanuguage syntactic parsing problem and for creating the related grammars .This paper presents a syntactic grammar developed in the link grammar formalism for Turkish which is an agglutinative language. In the link grammar formalism, the words of a sentence are linked with each other depending on their syntactic roles. Turkish has complex derivational and inflectional morphology, and derivational and inflection morphemes play important syntactic roles in the sentences. In order to develop a link grammar for Turkish, the lexical parts in the morphological representations of Turkish words are removed, and the links are created depending on the part of speech tags and inflectional morphemes in words. Furthermore, a derived word is separated at the derivational boundaries in order to treat each derivation morpheme as a special distinct word, and allow it to be linked with the rest of the sentence. The derivational morphemes of a word are also linked with each other with special links to indicate that they are parts of the same word. Finally the adapted unique link grammar formalism for Turkish provides flexibility for the linkage construction, and similar methods can be used for other languages with complex morphology. Finally, using the Delphi programming language, the link grammar related to the Azeri language was developed and implemented and then by selecting 250 random sentences, this grammar is evaluated and then tested. For 84.31% of the sentences, the result set of the parser contains the correct parse.

  4. ALGORITHM OF PRIMARY STATISTICAL ANALYSIS OF ARRAYS OF EXPERIMENTAL DATA

    Directory of Open Access Journals (Sweden)

    LAUKHIN D. V.

    2017-02-01

    Full Text Available Annotation. Purpose. Construction of an algorithm for preliminary (primary estimation of arrays of experimental data for further obtaining a mathematical model of the process under study. Methodology. The use of the main regularities of the theory of processing arrays of experimental values in the initial analysis of data. Originality. An algorithm for performing a primary statistical analysis of the arrays of experimental data is given. Practical value. Development of methods for revealing statistically unreliable values in arrays of experimental data for the purpose of their subsequent detailed analysis and construction of a mathematical model of the studied processes.

  5. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence.

    Science.gov (United States)

    Enderling, Heiko; Alexander, Nelson R; Clark, Emily S; Branch, Kevin M; Estrada, Lourdes; Crooke, Cornelia; Jourquin, Jérôme; Lobdell, Nichole; Zaman, Muhammad H; Guelcher, Scott A; Anderson, Alexander R A; Weaver, Alissa M

    2008-09-01

    Invadopodia are subcellular organelles thought to be critical for extracellular matrix (ECM) degradation and the movement of cells through tissues. Here we examine invadopodia generation, turnover, and function in relation to two structural aspects of the ECM substrates they degrade: cross-linking and fiber density. We set up a cellular automaton computational model that simulates ECM penetration and degradation by invadopodia. Experiments with denatured collagen (gelatin) were used to calibrate the model and demonstrate the inhibitory effect of ECM cross-linking on invadopodia degradation and penetration. Incorporation of dynamic invadopodia behavior into the model amplified the effect of cross-linking on ECM degradation, and was used to model feedback from the ECM. When the model was parameterized with spatial fibrillar dimensions that closely matched the organization, in real life, of native ECM collagen into triple-helical monomers, microfibrils, and macrofibrils, little or no inhibition of invadopodia penetration was observed in simulations of sparse collagen gels, no matter how high the degree of cross-linking. Experimental validation, using live-cell imaging of invadopodia in cells plated on cross-linked gelatin, was consistent with simulations in which ECM cross-linking led to higher rates of both invadopodia retraction and formation. Analyses of invadopodia function from cells plated on cross-linked gelatin and collagen gels under standard concentrations were consistent with simulation results in which sparse collagen gels provided a weak barrier to invadopodia. These results suggest that the organization of collagen, as it may occur in stroma or in vitro collagen gels, forms gaps large enough so as to have little impact on invadopodia penetration/degradation. By contrast, dense ECM, such as gelatin or possibly basement membranes, is an effective obstacle to invadopodia penetration and degradation, particularly when cross-linked. These results provide a

  6. Experimental characterization of a 400 Gbit/s orbital angular momentum multiplexed free-space optical link over 120 m.

    Science.gov (United States)

    Ren, Yongxiong; Wang, Zhe; Liao, Peicheng; Li, Long; Xie, Guodong; Huang, Hao; Zhao, Zhe; Yan, Yan; Ahmed, Nisar; Willner, Asher; Lavery, Martin P J; Ashrafi, Nima; Ashrafi, Solyman; Bock, Robert; Tur, Moshe; Djordjevic, Ivan B; Neifeld, Mark A; Willner, Alan E

    2016-02-01

    We experimentally demonstrate and characterize the performance of a 400-Gbit/s orbital angular momentum (OAM) multiplexed free-space optical link over 120 m on the roof of a building. Four OAM beams, each carrying a 100-Gbit/s quadrature-phase-shift-keyed channel are multiplexed and transmitted. We investigate the influence of channel impairments on the received power, intermodal crosstalk among channels, and system power penalties. Without laser tracking and compensation systems, the measured received power and crosstalk among OAM channels fluctuate by 4.5 dB and 5 dB, respectively, over 180 s. For a beam displacement of 2 mm that corresponds to a pointing error less than 16.7 μrad, the link bit error rates are below the forward error correction threshold of 3.8×10(-3) for all channels. Both experimental and simulation results show that power penalties increase rapidly when the displacement increases.

  7. Fundamentals of statistical experimental design and analysis

    CERN Document Server

    Easterling, Robert G

    2015-01-01

    Professionals in all areas - business; government; the physical, life, and social sciences; engineering; medicine, etc. - benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and t...

  8. Experimental design matters for statistical analysis

    DEFF Research Database (Denmark)

    Jensen, Signe Marie; Schaarschmidt, Frank; Onofri, Andrea

    2018-01-01

    , the experimental design is often more or less neglected when analyzing data. Two data examples were analyzed using different modelling strategies: Firstly, in a randomized complete block design, mean heights of maize treated with a herbicide and one of several adjuvants were compared. Secondly, translocation......BACKGROUND: Nowadays, the evaluation of effects of pesticides often relies on experimental designs that involve multiple concentrations of the pesticide of interest or multiple pesticides at specific comparable concentrations and, possibly, secondary factors of interest. Unfortunately...... of an insecticide applied to maize as a seed treatment was evaluated using incomplete data from an unbalanced design with several layers of hierarchical sampling. Extensive simulations were carried out to further substantiate the effects of different modelling strategies. RESULTS: It was shown that results from sub...

  9. Two MIS Analysis Methods: An Experimental Comparison.

    Science.gov (United States)

    Wang, Shouhong

    1996-01-01

    In China, 24 undergraduate business students applied data flow diagrams (DFD) to a mini-case, and 20 used object-oriented analysis (OOA). DFD seemed easier to learn, but after training, those using the OOA method for systems analysis made fewer errors. (SK)

  10. Heterogeneity analysis in 40 X-linked retinitis pigmentosa families

    Energy Technology Data Exchange (ETDEWEB)

    Teague, P.W.; Aldred, M.A.; Dempster, M.; Harrison, C.; Carothers, A.D.; Hardwick, L.J.; Evans, H.J.; Wright, A.F.; Strain, L.; Brock, D.J.H. (Univ. of Edinburgh (United Kingdom)) (and others)

    1994-07-01

    Analysis of genetic heterogeneity in 40 kindreds with X-linked retinitis pigmentosa (XLRP), with 20 polymorphic markers, showed that significant heterogeneity is present (P=.001) and that 56% of kindreds are of RP3 type and that 26% are of RP2 type. The location of the RP3 locus was found to be 0.4 cM distal to OTC in the Xp21.1 region, and that of the RP2 locus was 6.5 cM proximal to DXS7 in Xp11.2-p11.3. Bayesian probabilities of linkage to RP2, RP3, or to neither locus were calculated. This showed that 20 of 40 kindreds could be assigned to one or the other locus, with a probability >.70 (14 kindreds with RP3 and 6 kindreds with RP2 disease). A further three kindreds were found to be unlinked to either locus, with a probability >.8. The remaining 17 kindreds could not be classified unambiguously. This highlights the difficulty of classifying families in the presence of genetic heterogeneity, where two loci are separated by an estimated 16 cM. 34 refs., 1 fig., 4 tabs.

  11. Human Factors Experimental Design and Analysis Reference

    Science.gov (United States)

    2007-07-01

    8.75 83.36 8 =where, tObserved YPD = 53.75 YSD = 62.00 3.6.5. Within-Subjects t-Test (Cont’d) (Click in this red rectangle to see SAS calculations...expands computer experience into 3 levels, High, Medium , and Low, as compared to the original example that used only 2 levels of computer experience...High and Low. In this example, each of the 80 subjects who used the experimental text editor rated their computer experience as high, medium , or

  12. Semantic analysis of links in the musical Wikipedia

    DEFF Research Database (Denmark)

    Mølgaard, Lasse Lohilahti; Hansen, Lars Kai; Larsen, Jan

    2008-01-01

    are generated automatically, and they may even maliciously be used to promote certain topics. Wikipedia has been analyzed recently using methods fromWeb and text mining, however, the fact the link structure is different from the Web’s makes this approach questionable. To better understand the link structure...

  13. Plant DB link - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...tabases were collected by web-search. Data analysis method - Number of data entri...e Site Policy | Contact Us Plant DB link - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  14. Experimental analysis of cut welding in aluminium

    DEFF Research Database (Denmark)

    Dorph, Pernille; De Chiffre, Leonardo; Bay, Niels

    1993-01-01

    Cut welding is a newly developed cold pressure welding process. In the present work, an experimental investigation was carried out analyzing the mechanisms involved in cut welding of a block to a strip. Experiments were carried out in technically pure aluminium. The investigation has involved...... tensile testing and metallographic investigations of the welds. The results show that this variant of cut welding is a very reproducible process giving a weld strength equal to 30-40% the strength of the parent material. The experiments have shown that the reason for this relatively low strength...... is an uneven pressure distribution along the weld due to a wave formed during sliding. Attempts to alter the material flow during sliding are presented....

  15. Experimental Analysis on Flow Expansion Over Fan

    Science.gov (United States)

    Sittoni, L.; Paola, C.

    2005-12-01

    We present experimental evidence on the occurrence of large angles of flow expansion with no flow separation over depositional fans. The evolution of a number of self-formed experimental fans was analyzed using overhead images and detailed topographic surveys. Angles of flow expansion up to 45 degrees were found in association with a characteristic bed curvature. Although precise measurements indicate that transverse curvature appeared to slightly decrease downstream over the fans, an approximately constant value of curvature of about 0.1 (r/W = 0.1, where r is the dimensional curvature and W is the maximum width of the fan) fits well all fan sections analyzed. In addition, we found that bed curvature shows a weak proportional dependence with fan expansion angles (alpha around 20 degrees, where alpha is the local plan angle). The curvature appears sufficient to explain the common occurrence of unchannelized, simple fans with opening angles, and hence rates of bedload divergence, much larger than would be predicted from jet theory. We have also analyzed fan development. In our experiments, an instability phenomenon causes a sudden increase in channel width, in association with the formation of a scour. A common development pattern was observed: the upstream-migrating scour initiates flow expansion, inducing in turn the formation of a transient concave heart-shaped fan shape that then slowly develops into a final, steady cone-shaped deposit. Most of the deposition appears to occur during the initial expansion phase. During final steady conditions, fans were also observed to reach values of L/0.5W (L is the final fan length and W is the fan width) approximately constant and in the range 2-4.

  16. An experimental analysis of canopy flows

    Science.gov (United States)

    Segalini, Antonio; Fransson, Jens H. M.; Alfredsson, P. Henrik

    2011-12-01

    An analysis of forest canopy flows with a wind tunnel model at high Reynolds number is presented and discussed. Measured mean velocity and Reynolds stress profiles agree with observations made in real canopies with no sensible Reynolds number dependence, adding confidence to the results obtained with the present setup. The analysis of power density spectra of the three velocity components and of the shear stress co-spectra is reported with new coordinate scalings able to improve the collapse of the spectra compared to standard normalizations. This scaling is mostly based on the respective integral time scale and a simple fit is proposed to estimate such a quantity in real canopies. From the analysis of joint probability density functions, three different regions have been localized where a change in the coherent structure behavior is supposed to take place, similarly to what happens in rough wall turbulent boundary layers.

  17. Performance Analysis of ARQ-Based RF-FSO Links

    KAUST Repository

    Makki, Behrooz

    2017-02-22

    We study the performance of hybrid radio-frequency (RF) and free-space optical (FSO) links using automatic repeat request (ARQ). We derive closed-form expressions for the throughput and outage probability with different channel models. We also evaluate the effect of adaptive power allocation between the ARQ retransmissions on the system performance. The results show that joint implementation of the RF and FSO links leads to substantial performance improvement, compared to the cases with only the RF or the FSO link.

  18. Assessment of capacity support and scattering in experimental high speed vehicle to vehicle MIMO links

    DEFF Research Database (Denmark)

    Eggers, Patrick Claus F.; Brown, Tim; Olesen, Kim

    2007-01-01

    Preliminary results on the use of the vehicle to vehicle MIMO channel in a rural highway environment are presented. This is looked at both in terms of the available spatial multiplexing through singular value decomposition and also angular distribution within the channel. Results indicate a strong...... predominant line of sight link in general while instances of scattering from other vehicles will cause changes in the Doppler spectrum as well as beamforming jitter....

  19. Analysis of the preliminary optical links between ARTEMIS and the Optical Ground Station

    Science.gov (United States)

    Reyes Garcia-Talavera, Marcos; Chueca, Sergio; Alonso, Angel; Viera, Teodora; Sodnik, Zoran

    2002-12-01

    In the frame of the SILEX project, the European Space Agency (ESA) has put into orbit two Laser Communication Terminals, to establish an experimental free space optical communication link between a GEO satellite (ARTEMIS) and a LEO satellite (SPOT IV), to relay earth observation data. In order to perform In Orbit Testing (IOT) of these, and other, optical communications systems, ESA and the Instituto de Astrofisica de Canarias (IAC) reached an agreement for building the Optical Ground Station (OGS), in the Teide Observatory of the IAC. With ARTEMIS placed in a circular parking orbit at about 31000 kilometres, its optical payload has been preliminary tested with the OGS. First results and analysis are presented on the space-to-ground bi-directional link, including pointing acquisition and tracking performance, Bit-Error Rate (BER) and transmitted beam divergence effects related with atmospheric models and predictions. Future plans include deeper optical bi-directional communication tests of OGS, not only with ARTEMIS but also with OSCAR-40 (downlink) and SMART-1 (up-link) satellites, in order to do a full characterisation of the performances of laser beam propagation through atmospheric turbulence and a comparison with theoretical predictions.

  20. “Zero-length” Cross-linking in Solid State as an Approach for Analysis of Protein -Protein Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Elshafey, Ahmed; Tolic, Nikola; Young, Malin M.; Sale, Kenneth L.; Smith, Richard D.; Kery, Vladimir

    2006-03-01

    Analyzing the architecture of protein complexes is a difficult task. Chemical cross-linking is often used in combination with mass spectrometric analysis to elucidate the interaction interfaces between proteins. We have developed a new approach for the analysis of interacting interfaces in protein complexes based on cross-linking in the solid state. Protein complexes are freeze-dried under vacuum and cross-links are introduced in the solid phase by dehydrating the protein in a non-water solvent, thus, creating peptide bonds between amino and carboxyl groups of the interacting peptides. Cross-linked proteins are digested into peptides with trypsin in both H216O and H218O and then readily distinguished in mass spectra by characteristic 8 atomic mass unit (amu) shifts reflecting incorporation of two 18O atoms into each C-terminus of proteolytic peptides. Computer analysis of mass spectrometry (MS) and MS/MS data is used to identify the cross-linked peptides.We demonstrated our method by cross-linking homooligomeric protein complexes alone or in a mixture of many other proteins. Cross-linking in the solid state was shown to be specific and reproducible. Glutathione-S-transferase (GST) from Schistosoma japonicum was studied in more detail. Twenty-seven unique intra-molecular and two inter-molecular cross-linked peptides were identified using tryptic mapping followed by LTQ-MS analysis. Identified cross-links were predominantly of amide origin, but six esters and thioesters were also found. Identified cross-linked peptides were validated by computational (visualization of cross-links in the three-dimensional [3D] structure of GST) and experimental (MS/MS) analyses. Most of the identified cross-links matched interacting peptides in the native 3D structure of GST indicating that the structure of GST and its oligomeric complex remained primarily intact after freeze drying. The pattern of oligomeric GST obtained in solid state was the same as that obtained in solution by Ru

  1. Experimental analysis of nature-nurture interactions.

    Science.gov (United States)

    Wyman, Robert J

    2005-06-01

    The presumed opposition of nature and nurture has been a major concern of western civilization since its beginnings. Christian theologians interpreted Adam and Eve's eating of the forbidden fruit as the origin of an inherited 'original sin'. Saint Augustine explicitly applied the concept to human mental development, arguing that, because of original sin, children are inclined toward evil and education requires physical punishment. For centuries, it was considered parents' moral and religious obligation, not to nurture their children, in our current sense of that word, but to beat the willfulness out of them. 16thC humanists fought back, arguing that "schools have become torture chambers" while it is adults "who corrupt young minds with evil". Locke's (1690) statement that children are born as a 'white paper' was crucial in rejecting the dogma of an inborn (and sinful) nature. The original sin vs. white paper argument merged with another ancient dichotomy: inborn instinct (which controls animal behavior) vs. the reason and free will which humans have. Darwin made the concept of inherited instinct, common to both man and animals, one cornerstone of his theory of evolution. The 20(th)C saw scientists recast the debate as instinct vs. learning, bitterly argued between behaviorists and ethologists. Laboratory experimentation and field observation showed that behavior could develop without learning but also that conditioning paradigms could powerfully mold behavior. The progress of genetics and neurobiology has led to the modern synthesis that neural development, and hence behavior, results from the interdependent action of both heredity and environment. Copyright 2005 Wiley-Liss, Inc.

  2. Experimental demonstration of multi-aperture digital coherent combining over a 3.2-km free-space link

    Science.gov (United States)

    Geisler, D. J.; Yarnall, T. M.; Schieler, C. M.; Stevens, M. L.; Robinson, B. S.; Hamilton, S. A.

    2017-02-01

    The next generation free-space optical communications infrastructure will need to support a wide variety of space-to-ground links. As a result of the limited size, weight, and power on space-borne assets, the ground terminals need to scale efficiently to large collection areas to support extremely long link distances or high data rates. Recent advances in integrated digital coherent receivers enable the coherent combining (i.e., full-field addition) of signals from several small apertures to synthesize an effective single large aperture. In this work, we experimentally demonstrate the coherent combining of signals received by four independent receive chains after propagation through a 3:2-km atmospheric channel. Measured results show the practicality of coherently combining the four received signals via digital signal processing after transmission through a turbulent atmosphere. In particular, near-lossless combining is demonstrated using the technique of maximal ratio combining.

  3. Experimental analysis of humanistic systems in decision making ...

    African Journals Online (AJOL)

    Experimental analysis of humanistic systems in decision making. ... Journal of Applied Science and Technology ... Computational techniques for generating intuitionistic fuzzy random numbers (IFRNs) for the formulation of test problems in the management of humanistic systems have been developed and implemented.

  4. 3-D Experimental Fracture Analysis at High Temperature

    Energy Technology Data Exchange (ETDEWEB)

    John H. Jackson; Albert S. Kobayashi

    2001-09-14

    T*e, which is an elastic-plastic fracture parameter based on incremental theory of plasticity, was determined numerically and experimentally. The T*e integral of a tunneling crack in 2024-T3 aluminum, three point bend specimen was obtained through a hybrid analysis of moire interferometry and 3-D elastic-plastic finite element analysis. The results were verified by the good agreement between the experimentally and numerically determined T*e on the specimen surface.

  5. A Tool for Beamforming and Real-Time Link Budget Analysis in Aeronautical Communications Using Kinematics

    Directory of Open Access Journals (Sweden)

    M. Cenk Erturk

    2016-01-01

    Full Text Available Aeronautical Communication (AC systems are likely to be a part of future tiered communication network structures. Therefore maintaining a robust AC link with a minimum power burden on the host platform has a critical importance. In this paper, we analyze the AC systems from a link budget analysis point of view and define the requirements for the parameters of link budget with an emphasize on antenna gains. First, we study the link budget analysis in an AC system. Then, we present a mathematical framework to provide an end-to-end link budget analysis utilizing the platform kinematics. Finally, we present the numerical results for typical AC scenarios and discuss that these results can be used for calculating the real-time link budget and electronic beamforming to provide a robust link.

  6. Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.

    Science.gov (United States)

    Witsch, Thilo J; Turowski, Pawel; Sakkas, Elpidoforos; Niess, Gero; Becker, Simone; Herold, Susanne; Mayer, Konstantin; Vadász, István; Roberts, Jesse D; Seeger, Werner; Morty, Rory E

    2014-02-01

    Bronchopulmonary dysplasia (BPD) is a common and serious complication of premature birth, characterized by a pronounced arrest of alveolar development. The underlying pathophysiological mechanisms are poorly understood although perturbations to the maturation and remodeling of the extracellular matrix (ECM) are emerging as candidate disease pathomechanisms. In this study, the expression and regulation of three members of the lysyl hydroxylase family of ECM remodeling enzymes (Plod1, Plod2, and Plod3) in clinical BPD, as well as in an experimental animal model of BPD, were addressed. All three enzymes were localized to the septal walls in developing mouse lungs, with Plod1 also expressed in the vessel walls of the developing lung and Plod3 expressed uniquely at the base of developing septa. The expression of plod1, plod2, and plod3 was upregulated in the lungs of mouse pups exposed to 85% O2, an experimental animal model of BPD. Transforming growth factor (TGF)-β increased plod2 mRNA levels and activated the plod2 promoter in vitro in lung epithelial cells and in lung fibroblasts. Using in vivo neutralization of TGF-β signaling in the experimental animal model of BPD, TGF-β was identified as the regulator of aberrant plod2 expression. PLOD2 mRNA expression was also elevated in human neonates who died with BPD or at risk for BPD, compared with neonates matched for gestational age at birth or chronological age at death. These data point to potential roles for lysyl hydroxylases in normal lung development, as well as in perturbed late lung development associated with BPD.

  7. Moving off the grid in an experimental, compressively sampled photonic link.

    Science.gov (United States)

    Nichols, J M; McLaughlin, C V; Bucholtz, F

    2015-07-13

    Perhaps the largest obstacle to practical compressive sampling is an inability to accurately, and sparsely describe the data one seeks to recover due to poor choice of signal model parameters. In such cases the recovery process will yield artifacts, or in many cases, fail completely. This work represents the first demonstration of a solution to this so-called "off-grid" problem in an experimental, compressively sampled system. Specifically, we show that an Alternating Convex Search algorithm is able to significantly reduce these data model errors in harmonic signal recovery.

  8. Genomewide association analysis for awn length linked to the seed ...

    Indian Academy of Sciences (India)

    We investigated the awn length of 529 rice cultivars and performed a Genomewide association studies (GWAS) in the indica andjaponica subpopulations, and the whole population. In total, we found 17 loci associated with awn length. Of these loci, seven were linked to previously reported quantitative trait loci, and one was ...

  9. Linking Design to Business Strategy Through Functional Analysis

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1997-01-01

    The paper discusses how designers, conducting design projects in specific organization's, can assure that the design of IT is appropriately linked to the organizations overall business strategy. A case study is presented in the form of a design project in a small public organization. Functional a...

  10. Microcredit–nutrition education link: A case study analysis of ...

    African Journals Online (AJOL)

    ... of their participation in the ENAM project. Successful women employed multiple strategies to overcome business challenges. Anecdotal evidence suggested that the microcredit-education link in this particular situation did positively impact women's lives with respect to their small businesses, their personal development, ...

  11. Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses

    Directory of Open Access Journals (Sweden)

    Van Dorsselaer Alain

    2009-02-01

    Full Text Available Abstract Background VPgs are viral proteins linked to the 5' end of some viral genomes. Interactions between several VPgs and eukaryotic translation initiation factors eIF4Es are critical for plant infection. However, VPgs are not restricted to phytoviruses, being also involved in genome replication and protein translation of several animal viruses. To date, structural data are still limited to small picornaviral VPgs. Recently three phytoviral VPgs were shown to be natively unfolded proteins. Results In this paper, we report the bacterial expression, purification and biochemical characterization of two phytoviral VPgs, namely the VPgs of Rice yellow mottle virus (RYMV, genus Sobemovirus and Lettuce mosaic virus (LMV, genus Potyvirus. Using far-UV circular dichroism and size exclusion chromatography, we show that RYMV and LMV VPgs are predominantly or partly unstructured in solution, respectively. Using several disorder predictors, we show that both proteins are predicted to possess disordered regions. We next extend theses results to 14 VPgs representative of the viral diversity. Disordered regions were predicted in all VPg sequences whatever the genus and the family. Conclusion Based on these results, we propose that intrinsic disorder is a common feature of VPgs. The functional role of intrinsic disorder is discussed in light of the biological roles of VPgs.

  12. Experimental Investigations of Microwave Signal Attenuation in Radio Link within Geophysical Information Transmission

    Science.gov (United States)

    Goponenko, A. S.; Stukach, O. V.; Kochumeev, V. A.; Mirmanov, A. B.

    2014-10-01

    The paper describes the basic results of the project "Borehole Microwave" as researchers design microwave pulse signal transfer through a drilling pipe as a new communication channel. Methods of the telemetry information transfer are investigated. The "measurements while drilling" (MWD) mock-up of system based on the new concept of creation of telemetry equipment is developed. The experimental bench for electro-physical researches of various media in the drilling pipes is carried out. Investigations of measurement of attenuation of microwave pulse in drilling pipes are presented. Results show a possibility of operation in perspective field of investigations. The data transfer through a new communication channel in microwave band will open new possibilities of improving of the measurement-while-drilling equipment.

  13. Habitat Selection and Behaviour of a Reintroduced Passerine: Linking Experimental Restoration, Behaviour and Habitat Ecology

    Science.gov (United States)

    Bennett, Victoria A.; Doerr, Veronica A. J.; Doerr, Erik D.; Manning, Adrian D.; Lindenmayer, David B.; Yoon, Hwan-Jin

    2013-01-01

    Habitat restoration can play an important role in recovering functioning ecosystems and improving biodiversity. Restoration may be particularly important in improving habitat prior to species reintroductions. We reintroduced seven brown treecreeper (Climacteris picumnus) social groups into two nature reserves in the Australian Capital Territory in south-eastern Australia. This study provided a unique opportunity to understand the interactions between restoration ecology, behavioural ecology and habitat ecology. We examined how experimental restoration treatments (addition of coarse woody debris, variations in ground vegetation cover and nest box installation) influenced the behaviour and microhabitat use of radio-tracked individuals to evaluate the success of restoration treatments. The addition of coarse woody debris benefited the brown treecreeper through increasing the probability of foraging on a log or on the ground. This demonstrated the value of using behaviour as a bio-indicator for restoration success. Based on previous research, we predicted that variations in levels of ground vegetation cover would influence behaviour and substrate use, particularly that brown treecreepers would choose sites with sparse ground cover because this allows better access to food and better vigilance for predators. However, there was little effect of this treatment, which was likely influenced by the limited overall use of the ground layer. There was also little effect of nest boxes on behaviour or substrate use. These results somewhat confound our understanding of the species based on research from extant populations. Our results also have a significant impact regarding using existing knowledge on a species to inform how it will respond to reintroduction and habitat restoration. This study also places great emphasis on the value of applying an experimental framework to ecological restoration, particularly when reintroductions produce unexpected outcomes. PMID:23349923

  14. Habitat selection and behaviour of a reintroduced passerine: linking experimental restoration, behaviour and habitat ecology.

    Directory of Open Access Journals (Sweden)

    Victoria A Bennett

    Full Text Available Habitat restoration can play an important role in recovering functioning ecosystems and improving biodiversity. Restoration may be particularly important in improving habitat prior to species reintroductions. We reintroduced seven brown treecreeper (Climacteris picumnus social groups into two nature reserves in the Australian Capital Territory in south-eastern Australia. This study provided a unique opportunity to understand the interactions between restoration ecology, behavioural ecology and habitat ecology. We examined how experimental restoration treatments (addition of coarse woody debris, variations in ground vegetation cover and nest box installation influenced the behaviour and microhabitat use of radio-tracked individuals to evaluate the success of restoration treatments. The addition of coarse woody debris benefited the brown treecreeper through increasing the probability of foraging on a log or on the ground. This demonstrated the value of using behaviour as a bio-indicator for restoration success. Based on previous research, we predicted that variations in levels of ground vegetation cover would influence behaviour and substrate use, particularly that brown treecreepers would choose sites with sparse ground cover because this allows better access to food and better vigilance for predators. However, there was little effect of this treatment, which was likely influenced by the limited overall use of the ground layer. There was also little effect of nest boxes on behaviour or substrate use. These results somewhat confound our understanding of the species based on research from extant populations. Our results also have a significant impact regarding using existing knowledge on a species to inform how it will respond to reintroduction and habitat restoration. This study also places great emphasis on the value of applying an experimental framework to ecological restoration, particularly when reintroductions produce unexpected outcomes.

  15. Cross-impact analysis experimentation using two techniques to ...

    African Journals Online (AJOL)

    Cross-impact analysis relies on decision makers to provide marginal probability estimates of interdependent events. Generally, these have to be revised in order to ensure overall system coherency. This paper describes cross-impact analysis experimentation in which a Monte Carlo based approach and a dierence equation ...

  16. Applications of Digital Image Analysis in Experimental Mechanics

    DEFF Research Database (Denmark)

    Lyngbye, J. : Ph.D.

    The present thesis "Application of Digital Image Analysis in Experimental Mechanics" has been prepared as a part of Janus Lyngbyes Ph.D. study during the period December 1988 to June 1992 at the Department of Building technology and Structural Engineering, University of Aalborg, Denmark....... In this thesis attention will be focused on optimal use and analysis of the information of digital images. This is realized during investigation and application of parametric methods in digital image analysis. The parametric methods will be implemented in applications representative for the area of experimental...

  17. Feasibility Study and Experimental Verification of Simplified Fiber-Supported 60-GHz Picocell Mobile Backhaul Links

    DEFF Research Database (Denmark)

    Lebedev, Alexander; Pang, Xiaodan; Vegas Olmos, Juan José

    2013-01-01

    analysis and comparison with an alternative E-band (60–90 GHz) technology. The 60-GHz fiber-wireless-fiber setup is then introduced: two spans of up to 20 km of optical fiber are deployed and bridged by up to 4 m of wireless distance. The 60-GHz radio-over-fiber technology is utilized in the first span...

  18. Analysis of sensory ratings data with cumulative link models

    DEFF Research Database (Denmark)

    Christensen, Rune Haubo Bojesen; Brockhoff, Per B.

    2013-01-01

    replications are often expected to be too liberal because of over-dispersion.We describe how this depends on whether the experimental design is fully randomized or blocked. For the latter situation we describe how naive tests can be stronger than over-dispersion adjusting approaches, and that mixed effects...

  19. Experimental and theoretical analysis of cracking in drying soils

    OpenAIRE

    Lakshmikantha, M.R.

    2009-01-01

    The thesis focuses on the experimental and theoretical aspects of the process of cracking in drying soils. The results and conclusions were drawn from an exhaustive experimental campaign characterised by innovative multidisciplinary aspects incorporating Fracture Mechanics and classical Soil mechanics, aided with image analysis techniques. A detailed study of the previous works on the topic showed the absence of large scale fully monitored laboratory tests, while the existing studies were per...

  20. Applications of Digital Image Analysis in Experimental Mechanics

    OpenAIRE

    Lyngbye, J. : Ph.D.

    1992-01-01

    The present thesis "Application of Digital Image Analysis in Experimental Mechanics" has been prepared as a part of Janus Lyngbyes Ph.D. study during the period December 1988 to June 1992 at the Department of Building technology and Structural Engineering, University of Aalborg, Denmark. In this thesis attention will be focused on optimal use and analysis of the information of digital images. This is realized during investigation and application of parametric methods in digital image analysis...

  1. Experimental studies of control concepts for a parallel manipulator with flexible links

    Energy Technology Data Exchange (ETDEWEB)

    Burkhardt, Markus; Eberhard, Peter [University of Stuttgart, Pfaffenwaldring (Germany); Seifried, Robert [Hamburg University of Technology, Hamburg (Germany)

    2015-07-15

    Control of flexible multibody systems, such as flexible manipulators, is a challenging task. This is especially true if end-effector trajectory tracking is aspired. On the one hand, these systems require a large number of generalized coordinates to describe their dynamical behavior accurately. On the other hand, only a small subset of these values can be measured or reconstructed on-the-fly. Hence, it is difficult, if not nearly impossible, to use a state controller. In addition, flexible systems are under actuated, i.e. they possess less control inputs than generalized coordinates. In case of a non-collocated output controller, which is the case for end-effector trajectory tracking, the closed loop of the system might lose passivity and is non-minimum phase. In order to achieve end-effector trajectory tracking, exact and approximate feed-forward controls can be applied. In this work, two different versions of such concepts are compared experimentally. These model-based concepts are computed off-line and they supply, next to the required input values, a C1 -continuous solution of the complete state vector which can be used for feedback control. If the system is non-minimum phase, a two-sided boundary value problem has to be solved and the solution includes a pre-actuation as well as a post-actuation phase. While the exact method incorporates all dynamical effects of the flexible multibody system, the approximate concepts neglect certain implications, for example the dynamical effects due to the flexibility. In addition to the presentation of the theoretical basics of the control approaches and the underlying models, this contribution addresses some of the crucial obstacles, which have to be overcome for the operation of the test bench, e.g., signal conditioning, state reconstruction and friction compensation. Since the installed sensors do not allow the direct measurement of the end effector position, image tracking is used to judge the quality of the different

  2. Floor Heating with Displacement Ventilation: An Experimental and Numerical Analysis

    DEFF Research Database (Denmark)

    Causone, Francesco; Olesen, Bjarne W.; Corgnati, S.P.

    2010-01-01

    The effect of floor heating combined with displacement ventilation (DV) on thermal indoor environments and indoor air quality (IAQ) was studied by means of CFD. The numerical model was validated with experimental data. A typical office room was simulated, and one of the occupants was considered...... to simulate different kinds of contaminant sources, under the same boundary conditions. It was found that DV does not guarantee a better IAQ than full mixing when contaminant sources are not linked to heat sources, even when floor heating is used. Contaminants produced by powerful heat sources require high...

  3. Linking soil chemistry, treeline shifts and climate change: scenario modeling using an experimental approach

    Science.gov (United States)

    Mavris, Christian; Furrer, Gerhard; Anderson, Susanne; Blum, Alex; Wells, Aaron; Dahms, Dennis; Egli, Markus

    2014-05-01

    Climate change and global warming have a strong influence on the landscape development. As cold areas become warmer, both flora and fauna must adapt to new conditions (a). It is widely accepted that climate changes deeply influence the treeline shifts. In addition to that, wildfires, plant diseases and insect infestation (i.e. mountain pine beetle) can promote a selective replacement of plants, inhibiting some and favoring others, thus modifying the ecosystem in diverse ways. There is little knowledge on the behavior of soil chemistry when such changes occur. Will elemental availability become a crucial factor as a function of climate changes? The Sinks Canyon and Stough Basin - SE flank of the Wind River Range, Wyoming, USA - offer an ideal case study. Conceptually, the areas were divided into three main subsets: tundra, forest and a subarid environment. All soils were developed on granitoid moraines (b, c). From each subset, a liquid topsoil extract was produced and mixed with the solid subsoil samples in batch reactors at 50 °C. The batch experiments were carried out over 1800 h, and the progress of the dissolution was regularly monitored by analyzing liquid aliquots using IC and ICP-OES. The nutrients were mostly released within the first hours of the experiment. Silicon and Al were continuously released into the solution, while some alkali elements - i.e. Na - showed a more complex trend. Organic acids (acetic, citric) and other ligands produced during biodegradation played an active role in mineral dissolution and nutrient release. The mineral colloids detected in the extract (X-ray diffraction) can significantly control surface reactions (adsorption/desorption) and contributed to specific cationic concentrations. The experimental set up was then compared to a computed dissolution model using SerialSTEADYQL software (d, e). Decoding the mechanisms driving mineral weathering is the key to understand the main geochemical aspects of adaptation during climate

  4. Enhanced Performance Analysis of Inter-aircraft Optical Wireless Communication Link Using Array of Photodetectors

    Science.gov (United States)

    Singh, Mehtab

    2017-12-01

    This paper investigates the impact of various parameters on the performance of inter-aircraft optical wireless communication (IaOWC) link. Also, an improved performance analysis of a 2.5 Gbps IaOWC link using an array of photodetectors at the receiver terminal has been reported. The results show an increase in the SNR and total power of the received signal at a link distance of 100 km by deploying a photodetector array at the receiver terminal.

  5. Linking learner corpus and experimental data in studying second language learners’ knowledge of verb-argument constructions

    Directory of Open Access Journals (Sweden)

    Römer Ute

    2014-04-01

    Full Text Available This paper combines data from learner corpora and psycholinguistic experiments in an attempt to find out what advanced learners of English (first language backgrounds German and Spanish know about a range of common verbargument constructions (VACs, such as the ‘V about n’ construction (e.g. she thinks about chocolate a lot. Learners’ dominant verb-VAC associations are examined based on evidence retrieved from the German and Spanish subcomponents of ICLE and LINDSEI and collected in lexical production tasks in which participants complete VAC frames (e.g. ‘he ___ about the...’ with verbs that may fill the blank (e.g. talked, thought, wondered. The paper compares findings from the different data sets and highlights the value of linking corpus and experimental evidence in studying linguistic phenomena

  6. Glucose-Triggered Insulin Release from Fe3+-Cross-linked Alginate Hydrogel: Experimental Study and Theoretical Modeling.

    Science.gov (United States)

    Scheja, Sabrina; Domanskyi, Sergii; Gamella, Maria; Wormwood, Kelly L; Darie, Costel C; Poghossian, Arshak; Schöning, Michael J; Melman, Artem; Privman, Vladimir; Katz, Evgeny

    2017-06-20

    We study the mechanisms involved in the release, triggered by the application of glucose, of insulin entrapped in Fe 3+ -cross-linked alginate hydrogel particles further stabilized with a polyelectrolyte. Platelet-shaped alginate particles are synthesized containing enzyme glucose oxidase conjugated with silica nanoparticles, which are also entrapped in the hydrogel. Glucose diffuses in from solution, and production of hydrogen peroxide is catalyzed by the enzyme within the hydrogel. We argue that, specifically for the Fe 3+ -cross-linked systems, the produced hydrogen peroxide is further converted to free radicals via a Fenton-type reaction catalyzed by the iron cations. The activity of free radicals, as well as the reduction of Fe 3+ by the enzyme, and other mechanisms contribute to the decrease in density of the hydrogel. As a result, while the particles remain intact, void sizes increase and release of insulin ensues and is followed experimentally. A theoretical description of the involved processes is proposed and utilized to fit the data. It is then used to study the long-time properties of the release process that offers a model for designing new drug-release systems. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Comments on cognitive science in the experimental analysis of behavior.

    Science.gov (United States)

    Morris, E K; Higgins, S T; Bickel, W K

    1982-01-01

    Arguments are increasingly being made for the inclusion of cognitive science in the experimental analysis of behavior (TEAB). These arguments are described, and a critical analysis of them is presented, especially in regards to the logic of objective inference and the renewed use of cognitive intervening variables. In addition, one particular defining feature of cognitive processes (i.e., the absence of an immediate controlling stimulus) is described, along with alternative points of view stressing molar-molecular levels of analysis and historical causation. Finally, comments are made on the use of cognitive concepts and language in the behavioral sciences. On all of these issues, counter-arguments are based on available material in behavior analysis metatheory, concepts, and experimental practices.

  8. Parametric and experimental analysis using a power flow approach

    Science.gov (United States)

    Cuschieri, J. M.

    1990-01-01

    A structural power flow approach for the analysis of structure-borne transmission of vibrations is used to analyze the influence of structural parameters on transmitted power. The parametric analysis is also performed using the Statistical Energy Analysis approach and the results are compared with those obtained using the power flow approach. The advantages of structural power flow analysis are demonstrated by comparing the type of results that are obtained by the two analytical methods. Also, to demonstrate that the power flow results represent a direct physical parameter that can be measured on a typical structure, an experimental study of structural power flow is presented. This experimental study presents results for an L shaped beam for which an available solution was already obtained. Various methods to measure vibrational power flow are compared to study their advantages and disadvantages.

  9. Experimental modal analysis of an electric locomotive body

    Directory of Open Access Journals (Sweden)

    Manea Ion

    2017-01-01

    Full Text Available The study of the structural dynamics is essential for understanding and assessing of any engineering product performance, knowledge of dynamic structural response being fundamental to ensuring a sustainable and safe product functioning. From all techniques for structural response assessment, the experimental modal analysis (EMA provides one of the most comprehensive tools for collecting the experimental data, relevant for structure investigation and assessing of the structural response under normal or imposed operating conditions. Once identified the structure in terms of modal model, it can begin to its optimization to face new challenges or functioning tasks. The article presents an experimental modal analysis application, performed on a LEMA 6000kW electric locomotive body on the production cycle of SC Softronic Craiova. The application was made to validate the dynamic finite elements model realised in order to certify the crashworthiness locomotive design and to evaluate the body interaction with bogie and track to avoid the locomotive structural resonance phenomena.

  10. Lexical Link Analysis for the Haiti Earthquake Relief Operation Using Open Data Sources

    Science.gov (United States)

    2011-06-01

    measure obtained using the traditional quadratic assignment procedure correlation ( QAP , Hubert & Schultz, 1976) used in social sciences and social...network analysis. However, synergy defined here is calculated from lexical links instead of social network links which are commonly used. QAP ...calculates Pearson’s correlation coefficient between corresponding cells of the two data matrices. QAP also tests if the association between two networks

  11. Experimental Modal Analysis on Vibrations in the Building Construction

    OpenAIRE

    成瀬, 治興; 佐野, 泰之; 北畠, 弘基

    1996-01-01

    This paper describes some results of vibration propagation characteristics of two rooms next door to each other in the actual building construction (including floor, walls, and upstairfloor) by experimental modal analysis. In addition, we investigate about vibration response of measuring points by forced response and sensitivity analysis. The results are summarized as follows. The vibration of lower modes gives larger effect to vibration propagation characteristics of building construction th...

  12. Mathematical Models and the Experimental Analysis of Behavior

    Science.gov (United States)

    Mazur, James E.

    2006-01-01

    The use of mathematical models in the experimental analysis of behavior has increased over the years, and they offer several advantages. Mathematical models require theorists to be precise and unambiguous, often allowing comparisons of competing theories that sound similar when stated in words. Sometimes different mathematical models may make…

  13. The "Journal of the Experimental Analysis of Behavior" at Fifty

    Science.gov (United States)

    Laties, Victor G.

    2008-01-01

    The "Journal of the Experimental Analysis of Behavior" was founded in 1958 by a group of male psychologists, mainly from the northeastern USA and connected with either Harvard or Columbia. Fifty years later about 20% of both editors and authors reside outside this country and almost the same proportion is women. Other changes in the…

  14. Application of covariance analysis to feed/ ration experimental data ...

    African Journals Online (AJOL)

    Correlation and Regression analyses were used to adjust for the covariate – initial weight of the experimental birds. The Fisher's F statistic for the straight forward Analysis of Variance (ANOVA) showed significant differences among the rations. With the ANOVA, the calculated F statistic was 4.025, with a probability of 0.0149.

  15. Experimental and mechanical analysis of cement–nanotube ...

    Indian Academy of Sciences (India)

    Carbon nanotubes; cement; nanocomposites; finite-element method; modal analysis. 1. Introduction Researchers have attempted to estimate the mechanical properties of multi- and single-walled nanotubes (MWNTs and SWNTs, respectively) in manyways, including experimental, molecular dynamics (MD) and elastic ...

  16. Experimental bifurcation analysis of an impact oscillator – Determining stability

    DEFF Research Database (Denmark)

    Bureau, Emil; Schilder, Frank; Elmegård, Michael

    2014-01-01

    We propose and investigate three different methods for assessing stability of dynamical equilibrium states during experimental bifurcation analysis, using a control-based continuation method. The idea is to modify or turn off the control at an equilibrium state and study the resulting behavior. A...

  17. An Application of Brief Experimental Analysis with Early Writing

    Science.gov (United States)

    Parker, David C.; Dickey, Bradley N.; Burns, Matthew K.; McMaster, Kristen L.

    2012-01-01

    Students' poor performance on national assessments of writing suggests that educators need effective approaches to assess and intervene with writing problems. Brief experimental analysis (BEA) has supporting evidence for identifying interventions in reading, but little research has investigated BEA with writing. Early writing is an especially…

  18. Knowledge Management for the Analysis of Complex Experimentation.

    Science.gov (United States)

    Maule, R.; Schacher, G.; Gallup, S.

    2002-01-01

    Describes a knowledge management system that was developed to help provide structure for dynamic and static data and to aid in the analysis of complex experimentation. Topics include quantitative and qualitative data; mining operations using artificial intelligence techniques; information architecture of the system; and transforming data into…

  19. Analyzing Math-to-Mastery through Brief Experimental Analysis

    Science.gov (United States)

    Everett, Gregory E.; Swift, Honora S.; McKenney, Elizabeth L. W.; Jewell, Jeremy D.

    2016-01-01

    The current study evaluated the effectiveness of individualized math-to-mastery (MTM) interventions, selected though brief experimental analysis (BEA), at increasing math fluency skills for three elementary-aged females. As MTM has only been investigated as a multicomponent intervention, the present study utilized BEA to identify those specific…

  20. Experimental Data and Geometric Analysis Repository-EDGAR

    NARCIS (Netherlands)

    Aras, K.; Good, W.; Tate, J.; Burton, B.; Brooks, D.; Coll-Font, J.; Doessel, O.; Schulze, W.; Potyagaylo, D.; Wang, L.; Dam, P.M. van; MacLeod, R.

    2015-01-01

    INTRODUCTION: The "Experimental Data and Geometric Analysis Repository", or EDGAR is an Internet-based archive of curated data that are freely distributed to the international research community for the application and validation of electrocardiographic imaging (ECGI) techniques. The EDGAR project

  1. Anxiety-linked attentional bias and its modification: Illustrating the importance of distinguishing processes and procedures in experimental psychopathology research.

    Science.gov (United States)

    MacLeod, Colin; Grafton, Ben

    2016-11-01

    In this review of research concerning anxiety-linked attentional bias, we seek to illustrate a general principle that we contend applies across the breadth of experimental psychopathology. Specifically, we highlight how maintenance of a clear distinction between process and procedure serves to enhance the advancement of knowledge and understanding, while failure to maintain this distinction can foster confusion and misconception. We show how such clear differentiation has permitted the continuous refinement of assessment procedures, in ways that have led to growing confidence in the existence of the putative attentional bias process of interest, and also increasing understanding of its nature. In contrast, we show how a failure to consistently differentiate between process and procedure has contributed to confusion concerning whether or not attentional bias modification reliably alters anxiety vulnerability and dysfunction. As we demonstrate, such confusion can be avoided by distinguishing the process of attentional bias modification from the procedures that have been employed with the intention of evoking this target process. Such an approach reveals that procedures adopted with the intention of eliciting the attentional bias modification process do not always do so, but that successful evocation of the attentional bias modification process quite reliably alters anxiety symptomatology. We consider some of the specific implications for future research concerning attentional bias modification, while also pointing to the broader implications for experimental psychopathology research in general. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Outage Probability Analysis of FSO Links over Foggy Channel

    KAUST Repository

    Esmail, Maged Abdullah

    2017-02-22

    Outdoor Free space optic (FSO) communication systems are sensitive to atmospheric impairments such as turbulence and fog, in addition to being subject to pointing errors. Fog is particularly severe because it induces an attenuation that may vary from few dBs up to few hundreds of dBs per kilometer. Pointing errors also distort the link alignment and cause signal fading. In this paper, we investigate and analyze the FSO systems performance under fog conditions and pointing errors in terms of outage probability. We then study the impact of several effective communication mitigation techniques that can improve the system performance including multi-hop, transmit laser selection (TLS) and hybrid RF/FSO transmission. Closed-form expressions for the outage probability are derived and practical and comprehensive numerical examples are suggested to assess the obtained results. We found that the FSO system has limited performance that prevents applying FSO in wireless microcells that have a 500 m minimum cell radius. The performance degrades more when pointing errors appear. Increasing the transmitted power can improve the performance under light to moderate fog. However, under thick and dense fog the improvement is negligible. Using mitigation techniques can play a major role in improving the range and outage probability.

  3. Hold-Up Time Analysis of a DC-Link Module With a Series Voltage Compensator

    DEFF Research Database (Denmark)

    Wang, Huai; Liu, Wenchao; Chung, Henry

    2012-01-01

    -link capacitance when a certain period of hold-up time is considered. Trade-off design conditions are presented and the hold-up time is compared with the solution without the series voltage compensator. The analysis is crucial to power converters connected to critical loads when hold-up time is required......A dc-link module composed of dc-link capacitors and a series voltage compensator has been proposed. It has been verified that the module can reduce the dc-link capacitance to 10–20% while achieving a very low voltage ripple across its output terminals. This paper investigates the required dc...

  4. Comparing solute and particulate transport in streams using Notre Dame Linked Experimental Ecosystem Facility (ND-LEEF)

    Science.gov (United States)

    Shogren, A.; Tank, J. L.; Aubeneau, A. F.; Bolster, D.

    2016-12-01

    in streams and rivers. These processes co-vary across systems and are thus difficult to isolate. Therefore, to improve our understanding of drivers of fine-scale transport and retention of particles and solutes in streams, we experimentally compared transport and retention dynamics of two different particles (brewers yeast, 7μm; corn pollen, 70μm), a non-reactive solute (RhodamineWT), and a biologically reactive solute, nitrate (NO3-). We conducted experiments in four semi-natural constructed streams at the Notre Dame Linked Ecosystem Experimental Facility (ND-LEEF) in South Bend, Indiana. Each of the four 50 m replicate stream was lined with a unique configuration of substrate: pea gravel (PG, D50 = 0.5cm) and cobble (COB, D50 = 5cm) and structural complexity: alternating 2m sections of PG and COB substrates (ALT) and a random 50/50 mix (MIX). We allowed the experimental streams to naturally colonize with biofilm and periphyton throughout the summer sampling season. For particles, we estimated transport distance (Sp) and deposition velocity (vdep) and for solutes, we estimated uptake lengths (Sw) and uptake velocity (vf) using a short-term pulse addition technique. Sp and vdep were variable for particles, and were most strongly predicted by biofilm colonization on substrata in each stream. Biofilm accumulation also increased uptake of the reactive solute, though in contrast to particles, there were no significant differences in Sw or vf among streams suggesting that substrate type was not the main driver of reactive solute retention. These results emphasize the dynamic relationship between the physical and biological drivers influencing particle and solute retention in streams. Differential uptake of particles and solutes highlights the non stationarity of controlling variables along spatial or temporal continua. Even in highly controlled systems like those at ND-LEEF, physical vs. biological drivers are difficult to isolate.

  5. Cross-linked survey analysis is an approach for separating cause and effect in survey research.

    Science.gov (United States)

    Redelmeier, Donald A; Thiruchelvam, Deva; Lustig, Andrew J

    2015-01-01

    We developed a new research approach, called cross-linked survey analysis, to explore how an acute exposure might lead to changes in survey responses. The goal was to identify associations between exposures and outcomes while reducing some ambiguities related to interpreting cause and effect in survey responses from a population-based community questionnaire. Cross-linked survey analysis differs from a cross-sectional, longitudinal, and panel survey analysis by individualizing the timeline to the unique history of each respondent. Cross-linked survey analysis, unlike a repeated-measures self-matching design, does not track changes in a repeated survey question given to the same respondent at multiple time points. Pilot data from three analyses (n = 1,177 respondents) illustrate how a cross-linked survey analysis can control for population shifts, temporal trends, and reverse causality. Accompanying graphs provide an intuitive display to readers, summarize results, and show differences in response distributions. Population-based individual-level linkages also reduce selection bias and increase statistical power compared with a single-center cross-sectional survey. Cross-linked survey analysis has limitations related to unmeasured confounding, pragmatics, survivor bias, statistical models, and the underlying artifacts in survey responses. We suggest that a cross-linked survey analysis may help in epidemiology science using survey data. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Data Link Test and Analysis System/ATCRBS Transponder Test System Technical Reference

    Science.gov (United States)

    1990-05-01

    This document references material for personnel using or making software changes : to the Data Link Test and Analysis System (DATAS) for Air Traffic Control Radar : Beacon System (ATCRBS) transponder testing and data collection. This is one of : a se...

  7. Principles of Experimental Design for Big Data Analysis.

    Science.gov (United States)

    Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

    2017-08-01

    Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis.

  8. Principles of Experimental Design for Big Data Analysis

    Science.gov (United States)

    Drovandi, Christopher C; Holmes, Christopher; McGree, James M; Mengersen, Kerrie; Richardson, Sylvia; Ryan, Elizabeth G

    2016-01-01

    Big Datasets are endemic, but are often notoriously difficult to analyse because of their size, heterogeneity and quality. The purpose of this paper is to open a discourse on the potential for modern decision theoretic optimal experimental design methods, which by their very nature have traditionally been applied prospectively, to improve the analysis of Big Data through retrospective designed sampling in order to answer particular questions of interest. By appealing to a range of examples, it is suggested that this perspective on Big Data modelling and analysis has the potential for wide generality and advantageous inferential and computational properties. We highlight current hurdles and open research questions surrounding efficient computational optimisation in using retrospective designs, and in part this paper is a call to the optimisation and experimental design communities to work together in the field of Big Data analysis. PMID:28883686

  9. An Experimental Metagenome Data Management and AnalysisSystem

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, Victor M.; Korzeniewski, Frank; Palaniappan, Krishna; Szeto, Ernest; Ivanova, Natalia N.; Kyrpides, Nikos C.; Hugenholtz, Philip

    2006-03-01

    The application of shotgun sequencing to environmental samples has revealed a new universe of microbial community genomes (metagenomes) involving previously uncultured organisms. Metagenome analysis, which is expected to provide a comprehensive picture of the gene functions and metabolic capacity of microbial community, needs to be conducted in the context of a comprehensive data management and analysis system. We present in this paper IMG/M, an experimental metagenome data management and analysis system that is based on the Integrated Microbial Genomes (IMG) system. IMG/M provides tools and viewers for analyzing both metagenomes and isolate genomes individually or in a comparative context.

  10. Stiffness analysis and experimental validation of robotic systems

    Science.gov (United States)

    Carbone, Giuseppe

    2011-06-01

    Stiffness can be considered of primary importance in order to guarantee the successful use of any robotic system for a given task. Therefore, this paper proposes procedures for carrying out both numerical and experimental estimations of stiffness performance for multibody robotic systems. The proposed numerical procedure is based on models with lumped parameters for deriving the Cartesian stiffness matrix. Stiffness performance indices are also proposed for comparing stiffness performance. Then, an experimental procedure for the evaluation stiffness performance is proposed as based on a new measuring system named as Milli-CATRASYS (Milli Cassino Tracking System) and on a trilateration technique. Cases of study are reported to show the soundness and engineering feasibility of both the proposed numerical formulation for stiffness analysis and experimental validation of stiffness performance.

  11. Evaluation of UVA Cytotoxicity for Human Endothelium in an Ex Vivo Corneal Cross-linking Experimental Setting.

    Science.gov (United States)

    Mooren, Pepijn; Gobin, Laure; Bostan, Nezahat; Wouters, Kristien; Zakaria, Nadia; Mathysen, Danny G P; Koppen, Carina

    2016-01-01

    To evaluate endothelial cytotoxicity after exposure of human corneas to ultraviolet-A (UVA) (λ = 365 nm; 5.4 J/cm(2)) in an experimental ex vivo corneal cross-linking setting. Sixteen pairs of human donor corneas were cut into two pieces. One piece of each cornea was treated with 0.025% riboflavin solution prior to UVA irradiation (5 minutes; 18 mW/cm(2)), whereas the other piece was not irradiated but treated with riboflavin (right eye) or preservation medium (left eye). By irradiating from the endothelial side, the UVA dosage applied to endothelial cells exceeded at least eight times the cytotoxic threshold established in animal models (0.65 J/cm(2)). Endothelial cell counts were performed by two independent investigators after storage (4 to 5 days at 31 °C) and staining (trypan blue, alizarin red). Normality (Q-Q plot; Shapiro-Wilk test) and equivalence (mixed-effects modeling with a 10% equivalence threshold) of the endothelial cell counts of the different groups were evaluated. Equivalence of mean endothelial cell density between both groups was observed: 2,237 ± 208 cells/mm(2) in UVA-irradiated pieces and 2,290 ± 281 cells/mm(2) in control pieces (mean difference of 53 ± 240 cells/mm(2) between both groups). Despite direct irradiation of human donor endothelium using the clinical dosage for cross-linking, equivalence in endothelial cell counts was observed between irradiated tissues and controls. Ex vivo human corneal endothelial cells seem to be far more resistant to riboflavin-enhanced UVA irradiation than previously estimated by animal experiments. Copyright 2016, SLACK Incorporated.

  12. The Nematoda Filarioidea: critical analysis linking molecular and traditional approaches

    Directory of Open Access Journals (Sweden)

    Bain O.

    2008-09-01

    Full Text Available The molecular analysis of the Filarioidea and the endobacteria Wolbachia is no more limited to the agents of human diseases and the diversified sampling permits a synthesis with the morphological and biological results. The validity of the genera with “uncoherent host range”, such as Mansonella, Litomosoides and Cercopithifilaria, is confirmed and, consequently, their evolution by host-switchings. Dirofilaria and Onchocerca, types of two subfamilies, appear more closely related than with other onchocercids. Waltonellinae from anurans and Oswaldofilariinae from reptiles have a basal position. These filariae, and some others also considered primitive, do not harbour Wolbachia. Evidence for transversal transmission of the bacteria and a second acquisition event is given with the supergroup F, identified in Mansonella, in one of the Cercopithifilaria species and in arthropods.

  13. Microbiologic, Pharmacokinetic, and Clinical Effects of Corneal Collagen Cross-Linking on Experimentally Induced Pseudomonas Keratitis in Rabbits.

    Science.gov (United States)

    Cosar, C Banu; Kucuk, Mutlu; Celik, Ekrem; Gonen, Tansu; Akyar, Isin; Serteser, Mustafa; Tokat, Fatma; Ince, Umit

    2015-10-01

    To determine the effects of corneal collagen cross-linking (CXL) on the penetration of topical 0.5% moxifloxacin, on the number of colony-forming units (CFUs) in the cornea, and on the clinical course in a rabbit eye model of experimentally induced Pseudomonas aeruginosa keratitis. In this prospective animal study, experimental Pseudomonas corneal ulcers were induced in 56 corneas of 28 albino New Zealand rabbits. The corneas were randomly divided into the following 4 groups: the control group (14 eyes), the MOX group (moxifloxacin) (14 eyes), the MOX + CXL group (14 eyes), and the CXL group (14 eyes). On day 4 of the experiment, the eyes in the control group were enucleated and CFU counting was performed. On day 10 of the experiment, all eyes were enucleated and CFU counting was performed. In the MOX and MOX + CXL groups, the moxifloxacin level in the cornea, aqueous humor, iris, plasma, and serum was measured by reverse-phase high-performance liquid chromatography. The difference in the corneal CFU count between the MOX group and the MOX + CXL group was not significant (P = 0.317). Clinical improvement was greatest in the MOX + CXL group (P < 0.001). The mean corneal moxifloxacin level was 0.391 ± 0.09 μg·mg in the MOX group versus 0.291 ± 0.09 μg·mg in the MOX + CXL group; as such, CXL did not have a significant effect on antibiotic penetrance (P = 0.386). Clinical improvement was greatest in the MOX + CXL group. The synergistic effect of CXL on corneal ulcer treatment is not through antibiotic penetrance.

  14. Investigation of ferrocement channels using experimental and finite element analysis

    Directory of Open Access Journals (Sweden)

    Hamid Eskandari

    2015-12-01

    Full Text Available It is necessary to design and calculate tensile reinforcement for ferrocement channels with various spans used in different structures such as rural houses and mosques. However, such analysis is challenging due to the application of different types of wire meshes, dissimilar tensile and compressive reinforcement, and mechanical properties of the mortar. The present study provided an experimental sample to assess deflection in a standard ferrocement channel (span: 4.5 m; width: 70 cm. The Abaqus Unified finite element analysis (FEA has been also used to model the ferrocement channel by various system supports and beam spans. The obtained results indicated the acceptable accuracy of FE simulations in the estimation of experimental values. Such models can thus be used as quick, simple, and inexpensive methods to calculate the optimal deflection of ferrocement channels for various spans and sizes of tensile reinforcement.

  15. SiSn diodes: Theoretical analysis and experimental verification

    KAUST Repository

    Hussain, Aftab M.

    2015-08-24

    We report a theoretical analysis and experimental verification of change in band gap of silicon lattice due to the incorporation of tin (Sn). We formed SiSn ultra-thin film on the top surface of a 4 in. silicon wafer using thermal diffusion of Sn. We report a reduction of 0.1 V in the average built-in potential, and a reduction of 0.2 V in the average reverse bias breakdown voltage, as measured across the substrate. These reductions indicate that the band gap of the silicon lattice has been reduced due to the incorporation of Sn, as expected from the theoretical analysis. We report the experimentally calculated band gap of SiSn to be 1.11 ± 0.09 eV. This low-cost, CMOS compatible, and scalable process offers a unique opportunity to tune the band gap of silicon for specific applications.

  16. EXPERIMENTAL ANALYSIS OF THE CHARACTERISTIC PERFORMANCE OF STANDALONE PHOTOVOLTAIC SYSTEM

    OpenAIRE

    Birendra Kishore; Anirban Nandy*; O. P. Pandey

    2016-01-01

    This paper demonstrates an insight solar PV Stand Alone system which is a practical model with a halogen light source. At different situations the performance of solar PV cells are analyzed. The system produces power with depending on the change in halogen light intensity & temperature. A theoretical & experimental analysis of the PV cell can be achieved. In this paper the I-V & P-V characteristic of the solar photovoltaic cells with changes in temperature and isolation have been ...

  17. A factorial analysis experimentation of inappropriate waste disposal

    OpenAIRE

    S. A. Oke, K. O. Awofeso

    2006-01-01

    This paper presents a statistical approach to estimating the effects of psychological factors on humans due to inappropriate waste disposal in the environment. Factorial experimental analysis is combined with the concepts of transition matrix and steady state conditions. An adequate understanding into the statistical quantification of the waste disposal concept would aid policy makers in effective decision making and the proper control of environment. The feasibility of developing statistical...

  18. An experimental analysis on OSPF-TE convergence time

    Science.gov (United States)

    Huang, S.; Kitayama, K.; Cugini, F.; Paolucci, F.; Giorgetti, A.; Valcarenghi, L.; Castoldi, P.

    2008-11-01

    Open shortest path first (OSPF) protocol is commonly used as an interior gateway protocol (IGP) in MPLS and generalized MPLS (GMPLS) networks to determine the topology over which label-switched paths (LSPs) can be established. Traffic-engineering extensions (network states such as link bandwidth information, available wavelengths, signal quality, etc) have been recently enabled in OSPF (henceforth, called OSPF-TE) to support shortest path first (SPF) tree calculation upon different purposes, thus possibly achieving optimal path computation and helping improve resource utilization efficiency. Adding these features into routing phase can exploit the OSPF robustness, and no additional network component is required to manage the traffic-engineering information. However, this traffic-engineering enhancement also complicates OSPF behavior. Since network states change frequently upon the dynamic trafficengineered LSP setup and release, the network is easily driven from a stable state to unstable operating regimes. In this paper, we focus on studying the OSPF-TE stability in terms of convergence time. Convergence time is referred to the time spent by the network to go back to steady states upon any network state change. An external observation method (based on black-box method) is employed to estimate the convergence time. Several experimental test-beds are developed to emulate dynamic LSP setup/release, re-routing upon single-link failure. The experimental results show that with OSPF-TE the network requires more time to converge compared to the conventional OSPF protocol without TE extension. Especially, in case of wavelength-routed optical network (WRON), introducing per wavelength availability and wavelength continuity constraint to OSPF-TE suffers severe convergence time and a large number of advertised link state advertisements (LSAs). Our study implies that long convergence time and large number of LSAs flooded in the network might cause scalability problems in OSPF

  19. Experimental demonstration of a digital maximum likelihood based feedforward carrier recovery scheme for phase-modulated radio-over-fibre links

    DEFF Research Database (Denmark)

    Guerrero Gonzalez, Neil; Zibar, Darko; Yu, Xianbin

    2008-01-01

    Maximum likelihood based feedforward RF carrier synchronization scheme is proposed for a coherently detected phase-modulated radio-over-fiber link. Error-free demodulation of 100 Mbit/s QPSK modulated signal is experimentally demonstrated after 25 km of fiber transmission.......Maximum likelihood based feedforward RF carrier synchronization scheme is proposed for a coherently detected phase-modulated radio-over-fiber link. Error-free demodulation of 100 Mbit/s QPSK modulated signal is experimentally demonstrated after 25 km of fiber transmission....

  20. SPINE: SParse eIgengene NEtwork linking gene expression clusters in Dehalococcoides mccartyi to perturbations in experimental conditions.

    Science.gov (United States)

    Mansfeldt, Cresten B; Logsdon, Benjamin A; Debs, Garrett E; Richardson, Ruth E

    2015-01-01

    We present a statistical model designed to identify the effect of experimental perturbations on the aggregate behavior of the transcriptome expressed by the bacterium Dehalococcoides mccartyi strain 195. Strains of Dehalococcoides are used in sub-surface bioremediation applications because they organohalorespire tetrachloroethene and trichloroethene (common chlorinated solvents that contaminate the environment) to non-toxic ethene. However, the biochemical mechanism of this process remains incompletely described. Additionally, the response of Dehalococcoides to stress-inducing conditions that may be encountered at field-sites is not well understood. The constructed statistical model captured the aggregate behavior of gene expression phenotypes by modeling the distinct eigengenes of 100 transcript clusters, determining stable relationships among these clusters of gene transcripts with a sparse network-inference algorithm, and directly modeling the effect of changes in experimental conditions by constructing networks conditioned on the experimental state. Based on the model predictions, we discovered new response mechanisms for DMC, notably when the bacterium is exposed to solvent toxicity. The network identified a cluster containing thirteen gene transcripts directly connected to the solvent toxicity condition. Transcripts in this cluster include an iron-dependent regulator (DET0096-97) and a methylglyoxal synthase (DET0137). To validate these predictions, additional experiments were performed. Continuously fed cultures were exposed to saturating levels of tetrachloethene, thereby causing solvent toxicity, and transcripts that were predicted to be linked to solvent toxicity were monitored by quantitative reverse-transcription polymerase chain reaction. Twelve hours after being shocked with saturating levels of tetrachloroethene, the control transcripts (encoding for a key hydrogenase and the 16S rRNA) did not significantly change. By contrast, transcripts for DET

  1. SPINE: SParse eIgengene NEtwork linking gene expression clusters in Dehalococcoides mccartyi to perturbations in experimental conditions.

    Directory of Open Access Journals (Sweden)

    Cresten B Mansfeldt

    Full Text Available We present a statistical model designed to identify the effect of experimental perturbations on the aggregate behavior of the transcriptome expressed by the bacterium Dehalococcoides mccartyi strain 195. Strains of Dehalococcoides are used in sub-surface bioremediation applications because they organohalorespire tetrachloroethene and trichloroethene (common chlorinated solvents that contaminate the environment to non-toxic ethene. However, the biochemical mechanism of this process remains incompletely described. Additionally, the response of Dehalococcoides to stress-inducing conditions that may be encountered at field-sites is not well understood. The constructed statistical model captured the aggregate behavior of gene expression phenotypes by modeling the distinct eigengenes of 100 transcript clusters, determining stable relationships among these clusters of gene transcripts with a sparse network-inference algorithm, and directly modeling the effect of changes in experimental conditions by constructing networks conditioned on the experimental state. Based on the model predictions, we discovered new response mechanisms for DMC, notably when the bacterium is exposed to solvent toxicity. The network identified a cluster containing thirteen gene transcripts directly connected to the solvent toxicity condition. Transcripts in this cluster include an iron-dependent regulator (DET0096-97 and a methylglyoxal synthase (DET0137. To validate these predictions, additional experiments were performed. Continuously fed cultures were exposed to saturating levels of tetrachloethene, thereby causing solvent toxicity, and transcripts that were predicted to be linked to solvent toxicity were monitored by quantitative reverse-transcription polymerase chain reaction. Twelve hours after being shocked with saturating levels of tetrachloroethene, the control transcripts (encoding for a key hydrogenase and the 16S rRNA did not significantly change. By contrast

  2. Analysis of voltage modulation based active damping techniques for small DC-link drive system

    DEFF Research Database (Denmark)

    Wang, Dong; Lu, Kaiyuan; Rasmussen, Peter Omand

    2015-01-01

    Small DC-link drive system, built with film capacitor in the DC link, may have the advantages of longer lifetime and the possibility to achieve a more compact design of capacitor bank at medium and high power rates. However, it exhibits instability problem, especially when it is fed by a soft grid...... without the requirements of the information of system parameters and operating conditions. Finally, active damping techniques with minimized current magnitude and total duty cycle are discussed, in order to fit various operating conditions. Simulation and experimental results are presented to verify...

  3. Regression Model Optimization for the Analysis of Experimental Data

    Science.gov (United States)

    Ulbrich, N.

    2009-01-01

    A candidate math model search algorithm was developed at Ames Research Center that determines a recommended math model for the multivariate regression analysis of experimental data. The search algorithm is applicable to classical regression analysis problems as well as wind tunnel strain gage balance calibration analysis applications. The algorithm compares the predictive capability of different regression models using the standard deviation of the PRESS residuals of the responses as a search metric. This search metric is minimized during the search. Singular value decomposition is used during the search to reject math models that lead to a singular solution of the regression analysis problem. Two threshold dependent constraints are also applied. The first constraint rejects math models with insignificant terms. The second constraint rejects math models with near-linear dependencies between terms. The math term hierarchy rule may also be applied as an optional constraint during or after the candidate math model search. The final term selection of the recommended math model depends on the regressor and response values of the data set, the user s function class combination choice, the user s constraint selections, and the result of the search metric minimization. A frequently used regression analysis example from the literature is used to illustrate the application of the search algorithm to experimental data.

  4. Link Prediction in Criminal Networks: A Tool for Criminal Intelligence Analysis

    OpenAIRE

    Giulia Berlusconi; Francesco Calderoni; Nicola Parolini; Marco Verani; Carlo Piccardi

    2017-01-01

    The problem of link prediction has recently received increasing attention from scholars in network science. In social network analysis, one of its aims is to recover missing links, namely connections among actors which are likely to exist but have not been reported because data are incomplete or subject to various types of uncertainty. In the field of criminal investigations, problems of incomplete information are encountered almost by definition, given the obvious anti-detection strategies s...

  5. Multipoint linkage analysis and homogeneity tests in 15 Dutch X-linked retinitis pigmentosa families

    NARCIS (Netherlands)

    Bergen, A. A.; van den Born, L. I.; Schuurman, E. J.; Pinckers, A. J.; van Ommen, G. J.; Bleekers-Wagemakers, E. M.; Sandkuijl, L. A.

    1995-01-01

    Linkage analysis and homogeneity tests were carried out in 15 Dutch families segregating X-linked retinitis pigmentosa (X L R P). The study included segregation data for eight polymorphic DNA markers from the short arm of the human X chromosome. The results of both multipoint linkage analysis in

  6. DMFC anode polarization: Experimental analysis and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, A.; Marchesi, R. [Dipartimento di Energetica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2008-01-03

    Anode two-phase flow has an important influence on DMFC performance and methanol crossover. In order to elucidate two-phase flow influence on anode performance, in this work, anode polarization is investigated combining experimental and modelling approach. A systematic experimental analysis of operating conditions influence on anode polarization is presented. Hysteresis due to operating condition is observed; experimental results suggest that it arises from methanol accumulation and has to be considered in evaluating DMFC performances and measurements reproducibility. A model of DMFC anode polarization is presented and utilised as tool to investigate anode two-phase flow. The proposed analysis permits one to produce a confident interpretation of the main involved phenomena. In particular, it confirms that methanol electro-oxidation kinetics is weakly dependent on methanol concentration and that methanol transport in gas phase produces an important contribution in anode feeding. Moreover, it emphasises the possibility to optimise anode flow rate in order to improve DMFC performance and reduce methanol crossover. (author)

  7. Fractal analysis of electrical trees in a cross-linked synthetic resin

    Science.gov (United States)

    Irurzun, I. M.; Vicente, J. L.; Cordero, M. C.; Mola, E. E.

    2001-01-01

    A statistical picture of dielectric breakdown in cross-linked polyester resins for a two-dimensional geometry is presented and discussed in this paper. A connection is established between the dielectric breakdown model (DBM) and the physical properties of the resin. Distribution propagation times of simulated trees obey a Weibull statistics, as was experimentally found. This adjustment is achieved by a redefinition of the unit of time, which is different from the one employed up to date. The experimental dependence of characteristic propagation times on the fractal dimension D can be reproduced in the range 1.2linking density, which implies a notion of universality that deserves to be explored.

  8. High Capacity Communications From Martian Distances. Part 1; Spacecraft Link Design Analysis

    Science.gov (United States)

    Vyas, Hemali N.; Schuchman, Leonard; Orr, Richard; Williams, Wallace Dan; Collins, Michael; Noreen, Gary

    2006-01-01

    High capacity space communications has been a desire for Human Exploration and Science missions. Current Mars missions operate at data rates of 120 kbps for telemetry downlink and it is desirable to study high rate communication links in the range of 100 Mbps to 1 Gbps data rates from Martian distances. This paper will present some assumed scenarios along with link design assumptions and link analysis for high capacity communications from Mars. The paper will focus on RF subsystems namely antenna and power for the downlink communication from a relay orbiter at Mars. The relay orbiter will communicate with the low orbit spacecrafts at Mars or any Martian surface elements such as robots, and relay the data back to the ground networks on Earth. The study will dive into the spacecraft downlink system design and communication link analysis between the relay orbiter and ground network on Earth for data rates ranging from 100 Mbps to 1 Gbps based on the assumed scenarios and link assumptions. With high rate links at larger distances, there will be a significant impact on the antenna and power requirements and the link design will make an attempt to minimize the mass of the RF subsystem on the spacecraft. The results of this study will be presented for three data rates 1 Gbps, 500 Mbps and 100 Mbps at maximum Mars to Earth distance of 2.67AU. The design will use a Ka-band downlink with 90% link availability, along with various ground network G/T assumptions and possible bandwidth efficient modulations. The paper will conclude with what types of high rate communication links are feasible from Martian distances and also identify a range of requirements for antenna and power technologies for these high capacity communications from Mars.

  9. Mass spectrometric analysis of a UV-cross-linked protein-DNA complex: tryptophans 54 and 88 of E. coli SSB cross-link to DNA

    DEFF Research Database (Denmark)

    Steen, Hanno; Petersen, Jørgen; Mann, Matthias

    2001-01-01

    . coli single-stranded DNA binding protein (SSB) that was UV-cross-linked to a 5-iodouracil containing DNA oligomer. Two methods were optimized to circumvent the need for standard liquid chromatography and gel electrophoresis, thereby dramatically increasing the overall sensitivity of the analysis......Protein-nucleic acid complexes are commonly studied by photochemical cross-linking. UV-induced cross-linking of protein to nucleic acid may be followed by structural analysis of the conjugated protein to localize the cross-linked amino acids and thereby identify the nucleic acid binding site. Mass...... spectrometry is becoming increasingly popular for characterization of purified peptide-nucleic acid heteroconjugates derived from UV cross-linked protein-nucleic acid complexes. The efficiency of mass spectrometry-based methods is, however, hampered by the contrasting physico-chemical properties of nucleic...

  10. Xlink Analyzer: software for analysis and visualization of cross-linking data in the context of three-dimensional structures.

    Science.gov (United States)

    Kosinski, Jan; von Appen, Alexander; Ori, Alessandro; Karius, Kai; Müller, Christoph W; Beck, Martin

    2015-03-01

    Structural characterization of large multi-subunit protein complexes often requires integrating various experimental techniques. Cross-linking mass spectrometry (XL-MS) identifies proximal protein residues and thus is increasingly used to map protein interactions and determine the relative orientation of subunits within the structure of protein complexes. To fully adapt XL-MS as a structure characterization technique, we developed Xlink Analyzer, a software tool for visualization and analysis of XL-MS data in the context of the three-dimensional structures. Xlink Analyzer enables automatic visualization of cross-links, identifies cross-links violating spatial restraints, calculates violation statistics, maps chemically modified surfaces, and allows interactive manipulations that facilitate analysis of XL-MS data and aid designing new experiments. We demonstrate these features by mapping interaction sites within RNA polymerase I and the Rvb1/2 complex. Xlink Analyzer is implemented as a plugin to UCSF Chimera, a standard structural biology software tool, and thus enables seamless integration of XL-MS data with, e.g. fitting of X-ray structures to EM maps. Xlink Analyzer is available for download at http://www.beck.embl.de/XlinkAnalyzer.html. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Digging in to Link Analysis Researches in Iran and all around the World: a Review Article

    Directory of Open Access Journals (Sweden)

    Fatemeh Nooshinfard

    2011-10-01

    Full Text Available Increasing websites quantity, specially scientific websites, there were many researches with concern of link analysis using webometrics by librarian and other scholars in different academic majors around the world. The purpose of this article was link analysis of all link analysis related papers from the beginning to February 19th 2009. The research based on Weiner, Amick, and Lee searching model in 2008, this study included 96 refereed papers extracted from international databases like Springer, Proquest, Sage, Emerald, IEEE, Science Direct and national databases such as Magiran and SID. These papers were studied focusing on their different parts like authors, affiliated organizations, purpose, methods, tools, keywords, date of publishing, publication, indexing databases and their suggestions. Moreover, analyzing those papers and studying any related models were the other purposes of the current article. The findings have been categorized and analyses in ten different sections.

  12. Determination of specific anti-leptospiral immunoglobulins M and G in sera of experimentally infected dogs by solid-phase enzyme-linked immunosorbent assay

    NARCIS (Netherlands)

    Frik, J.F.; Hartman, E.G.; Houten, M. van; Donk, J.A. van der

    1984-01-01

    The development and evaluation of an enzyme-linked immunosorbent assay (ELISA) to detect specific anti-leptospiral IgM and IgG in sera of dogs experimentally infected with Leptospira interrogans serotype canicola are reported. In all dogs specific anti-leptospiral IgM was detected from the second

  13. Analysis of the experimental positron lifetime spectra by neural networks

    Directory of Open Access Journals (Sweden)

    Avdić Senada

    2003-01-01

    Full Text Available This paper deals with the analysis of experimental positron lifetime spectra in polymer materials by using various algorithms of neural networks. A method based on the use of artificial neural networks for unfolding the mean lifetime and intensity of the spectral components of simulated positron lifetime spectra was previously suggested and tested on simulated data [Pžzsitetal, Applied Surface Science, 149 (1998, 97]. In this work, the applicability of the method to the analysis of experimental positron spectra has been verified in the case of spectra from polymer materials with three components. It has been demonstrated that the backpropagation neural network can determine the spectral parameters with a high accuracy and perform the decomposi-tion of lifetimes which differ by 10% or more. The backpropagation network has not been suitable for the identification of both the parameters and the number of spectral components. Therefore, a separate artificial neural network module has been designed to solve the classification problem. Module types based on self-organizing map and learning vector quantization algorithms have been tested. The learning vector quantization algorithm was found to have better performance and reliability. A complete artificial neural network analysis tool of positron lifetime spectra has been constructed to include a spectra classification module and parameter evaluation modules for spectra with a different number of components. In this way, both flexibility and high resolution can be achieved.

  14. Link Prediction in Criminal Networks: A Tool for Criminal Intelligence Analysis.

    Directory of Open Access Journals (Sweden)

    Giulia Berlusconi

    Full Text Available The problem of link prediction has recently received increasing attention from scholars in network science. In social network analysis, one of its aims is to recover missing links, namely connections among actors which are likely to exist but have not been reported because data are incomplete or subject to various types of uncertainty. In the field of criminal investigations, problems of incomplete information are encountered almost by definition, given the obvious anti-detection strategies set up by criminals and the limited investigative resources. In this paper, we work on a specific dataset obtained from a real investigation, and we propose a strategy to identify missing links in a criminal network on the basis of the topological analysis of the links classified as marginal, i.e. removed during the investigation procedure. The main assumption is that missing links should have opposite features with respect to marginal ones. Measures of node similarity turn out to provide the best characterization in this sense. The inspection of the judicial source documents confirms that the predicted links, in most instances, do relate actors with large likelihood of co-participation in illicit activities.

  15. Link Prediction in Criminal Networks: A Tool for Criminal Intelligence Analysis.

    Science.gov (United States)

    Berlusconi, Giulia; Calderoni, Francesco; Parolini, Nicola; Verani, Marco; Piccardi, Carlo

    2016-01-01

    The problem of link prediction has recently received increasing attention from scholars in network science. In social network analysis, one of its aims is to recover missing links, namely connections among actors which are likely to exist but have not been reported because data are incomplete or subject to various types of uncertainty. In the field of criminal investigations, problems of incomplete information are encountered almost by definition, given the obvious anti-detection strategies set up by criminals and the limited investigative resources. In this paper, we work on a specific dataset obtained from a real investigation, and we propose a strategy to identify missing links in a criminal network on the basis of the topological analysis of the links classified as marginal, i.e. removed during the investigation procedure. The main assumption is that missing links should have opposite features with respect to marginal ones. Measures of node similarity turn out to provide the best characterization in this sense. The inspection of the judicial source documents confirms that the predicted links, in most instances, do relate actors with large likelihood of co-participation in illicit activities.

  16. Experimental analysis for aerodynamic drag of the electric locomotives

    Directory of Open Access Journals (Sweden)

    Ioan SEBESAN

    2013-09-01

    Full Text Available The purpose of this paper is to make a comparative analysis on the influence of the aerodynamic drag, in case of the electric rail vehicles for a series of situations encountered in exploitation. The article presents experimental results obtained following a geometric modelling at scale 1: 12, on a modular model for the electric locomotives LE 060EA 5100kW and LE-MA 060 TransMontana 6000kW. Tests were made at INCAS (National Institute for Aerospace Research “ElieCarafoli” in the subsonic wind tunnel.

  17. Complex experimental analysis of rifle-shooter interaction

    Directory of Open Access Journals (Sweden)

    Michał Taraszewski, M.ScEng, PhD. candidate

    2017-10-01

    Full Text Available In this study, a complex analysis of a man-weapon interaction based on experimental effort is presented. The attention is focused on how a shooter can influence on a rifle, opposite to generally considered in literature rifle's impact on a shooter. It is shown, based on the kbk AKM weapon, that each support point of the rifle has an substantial impact on the system. It is said that identifying human reactions on weapon may let to describe gun movement and thus may be applied to weapon accuracy determination.

  18. A factorial analysis experimentation of inappropriate waste disposal

    Directory of Open Access Journals (Sweden)

    S. A. Oke, K. O. Awofeso

    2006-04-01

    Full Text Available This paper presents a statistical approach to estimating the effects of psychological factors on humans due to inappropriate waste disposal in the environment. Factorial experimental analysis is combined with the concepts of transition matrix and steady state conditions. An adequate understanding into the statistical quantification of the waste disposal concept would aid policy makers in effective decision making and the proper control of environment. The feasibility of developing statistical parameters for assessing the waste disposal concept is confirmed. The work shows the novelty of the approach.

  19. Analysis of a Combined Antenna Arrays and Reverse-Link Synchronous DS-CDMA System over Multipath Rician Fading Channels

    National Research Council Canada - National Science Library

    Kim Yong-Seok; Whang Keum-Chan

    2005-01-01

    We present the BER analysis of antenna array (AA) receiver in reverse-link asynchronous multipath Rician channels and analyze the performance of an improved AA system which applies a reverse-link synchronous transmission technique (RLSTT...

  20. Analysis of biogas transformation in experimental biogas plant

    Directory of Open Access Journals (Sweden)

    Eva Jelínková

    2011-01-01

    Full Text Available The topic of this paper is the analysis of anaerobic fermentation in an experimental biogas plant. Technological processes and operation parameters were monitored; these processes and parameters include, for example, the optimal structure of the input material and the consideration of the prolonging of the duration of the fermentation process. The goal of prolonging the fermentation process is to obtain higher biogas (and methane production and to decrease the fermentation residue effluvial emissions. Emphasis is also laid on the mutual co-fermentation of substrates with regard to further use of the results in solving technological problems in other biogas plants. This technological process was first monitored in 2009; that is, before the planned intensification and modernization of the experimental biogas plant. Thus, the evaluation of the process could become part of the planned intensification and modernization of the chosen biogas plant (extended by the addition of the second stage of methanogenesis. The results obtained from the experimental biogas plant, which is one of the pioneering biogas plants in the Czech Republic, may serve, to other biogas operators, as a base for the preparation of suitable input, and for improving the efficiency of anaerobic fermentation within their biogas plants. The goal of the improvement of the fermentation process is to fulfill the ecological aspects; that is, to cut down CO2 emissions and to reduce the negative impact of the fermentation process on the environment (reduction of effluvium and noise originating in biogas plants.

  1. Amplified energy harvester from footsteps: design, modeling, and experimental analysis

    Science.gov (United States)

    Wang, Ya; Chen, Wusi; Guzman, Plinio; Zuo, Lei

    2014-04-01

    This paper presents the design, modeling and experimental analysis of an amplified footstep energy harvester. With the unique design of amplified piezoelectric stack harvester the kinetic energy generated by footsteps can be effectively captured and converted into usable DC power that could potentially be used to power many electric devices, such as smart phones, sensors, monitoring cameras, etc. This doormat-like energy harvester can be used in crowded places such as train stations, malls, concerts, airport escalator/elevator/stairs entrances, or anywhere large group of people walk. The harvested energy provides an alternative renewable green power to replace power requirement from grids, which run on highly polluting and global-warming-inducing fossil fuels. In this paper, two modeling approaches are compared to calculate power output. The first method is derived from the single degree of freedom (SDOF) constitutive equations, and then a correction factor is applied onto the resulting electromechanically coupled equations of motion. The second approach is to derive the coupled equations of motion with Hamilton's principle and the constitutive equations, and then formulate it with the finite element method (FEM). Experimental testing results are presented to validate modeling approaches. Simulation results from both approaches agree very well with experimental results where percentage errors are 2.09% for FEM and 4.31% for SDOF.

  2. Statistics in experimental design, preprocessing, and analysis of proteomics data.

    Science.gov (United States)

    Jung, Klaus

    2011-01-01

    High-throughput experiments in proteomics, such as 2-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS), yield usually high-dimensional data sets of expression values for hundreds or thousands of proteins which are, however, observed on only a relatively small number of biological samples. Statistical methods for the planning and analysis of experiments are important to avoid false conclusions and to receive tenable results. In this chapter, the most frequent experimental designs for proteomics experiments are illustrated. In particular, focus is put on studies for the detection of differentially regulated proteins. Furthermore, issues of sample size planning, statistical analysis of expression levels as well as methods for data preprocessing are covered.

  3. Analysis of experimental biosensor/FIA lactose measurements

    Directory of Open Access Journals (Sweden)

    L.S. Ferreira

    2003-03-01

    Full Text Available Whey is an abundant effluent in the production of cheese and casein. The biotechnological utilization of this economically important and nutritive source is limited mainly because of the presence of high percentages of lactose. This disaccharide has poor solubility, which can cause crystallization and insufficient sweetness in dairy food; additionally, part of the adult population suffers from associated lactose intolerance diseases. There are several methods to determine lactose such as spectrophotometry, polarimetry, infrared spectroscopy, titrimetry and chromatography. However these methods are tedious and time-consuming due to long sample preparation. These disadvantages stimulated the development of an enzymatic lactose biosensor. It employs two immobilized enzymes, beta-galactosidase and glucose oxidase and the quantitative analysis of lactose is based on determination of oxygen consumption in the enzymatic reaction. The influence of temperature on the biosensor signal was experimentally studied. It was observed that a nonlinear relationship exists between the electric response of the biosensor - provided by CAFCA (Computer Assisted Flow Control & Analysis - ANASYSCON, Hannover - and lactose concentration. In this work, attempts were made to correlate these variables using a simple nonlinear model and multilayered neural networks, with the latter providing the best modeling of the experimental data.

  4. Experimental and failure analysis of the prosthetic finger joint implants

    Science.gov (United States)

    Naidu, Sanjiv H.

    Small joint replacement arthroplasty of the hand is a well accepted surgical procedure to restore function and cosmesis in an individual with a crippled hand. Silicone elastomers have been used as prosthetic material in various small hand joints for well over three decades. Although the clinical science aspects of silicone elastomer failure are well known, the physical science aspects of prosthetic failure are scant and vague. In the following thesis, using both an animal model, and actual retrieved specimens which have failed in human service, experimental and failure analysis of silicone finger joints are presented. Fractured surfaces of retrieved silicone trapezial implants, and silicone finger joint implants were studied with both FESEM and SEM; the mode of failure for silicone trapezium is by wear polishing, whereas the finger joint implants failed either by fatigue fracture or tearing of the elastomer, or a combination of both. Thermal analysis revealed that the retrieved elastomer implants maintained its viscoelastic properties throughout the service period. In order to provide for a more functional and physiologic arthroplasty a novel finger joint (Rolamite prosthesis) is proposed using more recently developed thermoplastic polymers. The following thesis also addresses the outcome of the experimental studies of the Rolamite prosthesis in a rabbit animal model, in addition to the failure analysis of the thermoplastic polymers while in service in an in vivo synovial environment. Results of retrieved Rolamite specimens suggest that the use for thermoplastic elastomers such as block copolymer based elastomers in a synovial environment such as a mammalian joint may very well be limited.

  5. Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins

    DEFF Research Database (Denmark)

    Jensen, Pernille Foged; Comamala Grau, Gerard; Trelle, Morten Beck

    2016-01-01

    -HDX) and the utility of this approach is demonstrated during analysis of the monoclonal antibody Trastuzumab for which it has been shown that the native conformational dynamics is dependent on the N-linked glycan. In summary, the HDX-MS workflow with integrated PNGase A deglycosylation enables analysis of the native...

  6. Identifying Effective Spelling Interventions Using a Brief Experimental Analysis and Extended Analysis

    Science.gov (United States)

    McCurdy, Merilee; Clure, Lynne F.; Bleck, Amanda A.; Schmitz, Stephanie L.

    2016-01-01

    Spelling is an important skill that is crucial to effective written communication. In this study, brief experimental analysis procedures were used to examine spelling instruction strategies (e.g., whole word correction; word study strategy; positive practice; and cover, copy, and compare) for four students. In addition, an extended analysis was…

  7. CLMSVault: A Software Suite for Protein Cross-Linking Mass-Spectrometry Data Analysis and Visualization.

    Science.gov (United States)

    Courcelles, Mathieu; Coulombe-Huntington, Jasmin; Cossette, Émilie; Gingras, Anne-Claude; Thibault, Pierre; Tyers, Mike

    2017-07-07

    Protein cross-linking mass spectrometry (CL-MS) enables the sensitive detection of protein interactions and the inference of protein complex topology. The detection of chemical cross-links between protein residues can identify intra- and interprotein contact sites or provide physical constraints for molecular modeling of protein structure. Recent innovations in cross-linker design, sample preparation, mass spectrometry, and software tools have significantly improved CL-MS approaches. Although a number of algorithms now exist for the identification of cross-linked peptides from mass spectral data, a dearth of user-friendly analysis tools represent a practical bottleneck to the broad adoption of the approach. To facilitate the analysis of CL-MS data, we developed CLMSVault, a software suite designed to leverage existing CL-MS algorithms and provide intuitive and flexible tools for cross-platform data interpretation. CLMSVault stores and combines complementary information obtained from different cross-linkers and search algorithms. CLMSVault provides filtering, comparison, and visualization tools to support CL-MS analyses and includes a workflow for label-free quantification of cross-linked peptides. An embedded 3D viewer enables the visualization of quantitative data and the mapping of cross-linked sites onto PDB structural models. We demonstrate the application of CLMSVault for the analysis of a noncovalent Cdc34-ubiquitin protein complex cross-linked under different conditions. CLMSVault is open-source software (available at https://gitlab.com/courcelm/clmsvault.git ), and a live demo is available at http://democlmsvault.tyerslab.com/ .

  8. Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads

    DEFF Research Database (Denmark)

    Mihet-Popa, Lucian; Groza, Voicu; Isleifsson, Fridrik Rafn

    2012-01-01

    Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads......Experimental Testing for Stability Analysis of Distributed Energy Resources Components with Storage Devices and Loads...

  9. Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults

    Directory of Open Access Journals (Sweden)

    Marco Corradi

    2015-11-01

    Full Text Available An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers. For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L’Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults.

  10. Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults

    Science.gov (United States)

    Corradi, Marco; Borri, Antonio; Castori, Giulio; Coventry, Kathryn

    2015-01-01

    An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers). For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L’Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults. PMID:28793697

  11. The Experimental Analysis Of An Innovative Yielding Metallic Damper

    Directory of Open Access Journals (Sweden)

    Venghiac Vasile-Mircea

    2015-05-01

    Full Text Available One of the most destructive natural phenomena is the earthquake. These events destroy lives, goods and disrupt human activities. For this reason the anti-seismic protection of buildings is a very important and of interest subject in Civil Engineering. In the case of structures with a low seismic energy dissipation capacity (for example steel frame structures with Slimdek composite floors, this problem becomes more complicated due to the requirement of dampers. In this paper an experimental study is presented regarding an innovative yielding metallic energy dissipation device, proposed by the author. An experiment is carried out on a shake table. By studying the results from the experiments and from the previous carried out numerical analysis we can conclude that this device provides a high anti-seismic protection for this type of structures.

  12. Creep and Shrinkage of High Strength Concretes: an Experimental Analysis

    Directory of Open Access Journals (Sweden)

    Berenice Martins Toralles carbonari

    2002-01-01

    Full Text Available The creep and shrinkage behaviour of high strength silica fume concretes is significantly different from that of conventional concretes. In order to represent the proper time-dependent response of the material in structural analysis and design, these aspects should be adequately quantified. This paper discusses an experimental setup that is able to determine the creep and shrinkage of concrete from the time of placing. It also compares different gages that can be used for measuring the strains. The method is applied to five different concretes in the laboratory under controlled environmental conditions. The phenomena that are quantified can be classified as basic shrinkage, drying shrinkage, basic creep and drying creep. The relative importance of these mechanisms in high strength concrete will also be presented.

  13. LIFT on Keck: analysis of performance and first experimental results

    Science.gov (United States)

    Plantet, C.; Wizinowich, P.; Fusco, T.; Neichel, B.; Ragland, S.; Femenia, B.; Rampy, R.

    2016-07-01

    Wavefront sensing in the near infrared has become an attractive option with the advent of new low-noise infrared detectors, such as the SAPHIRA (Selex) and RAPID (CEA/Sofradir) APD arrays. The performance improvements obtained with the H2RG-based Keck I near-infrared tip-tilt sensor is motivating the implementation of a near-infrared low-order sensor for Keck II. The recently proposed focal plane sensor algorithm LIFT could fulfill this role. We show here an analysis of performance, demonstrating that LIFT would provide a significant gain ( 1 magnitude) over the current tip/tilt sensor at low flux, as well as the first experimental validation of LIFT on Keck with a calibration source.

  14. Laser-Based Lighting: Experimental Analysis and Perspectives

    Directory of Open Access Journals (Sweden)

    Nicola Trivellin

    2017-10-01

    Full Text Available This paper presents an extensive analysis of the operating principles, theoretical background, advantages and limitations of laser-based lighting systems. In the first part of the paper we discuss the main advantages and issues of laser-based lighting, and present a comparison with conventional LED-lighting technology. In the second part of the paper, we present original experimental data on the stability and reliability of phosphor layers for laser lighting, based on high light-intensity and high-temperature degradation tests. In the third part of the paper (for the first time we present a detailed comparison between three different solutions for laser lighting, based on (i transmissive phosphor layers; (ii a reflective/angled phosphor layer; and (iii a parabolic reflector, by discussing the advantages and drawbacks of each approach. The results presented within this paper can be used as a guideline for the development of advanced lighting systems based on laser diodes.

  15. Final safety analysis report for the IFR Experimental Fuels Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Batte, G. L.; Wilkes, C. W.

    1986-05-01

    The Integral Fast Reactor (IFR) program requires irradiation of a number of U-Pu-Zr metallic alloy elements, to obtain experimental information prior to large scale production of this fuel. The IFR Experimental Fuels Laboratory (EFL) will be established for the fabrication of a limited number uranium-plutonium-zirconium (U-Pu-Zr) alloy fuel elements, as well as the development of process concepts and parameters needed to make the fuel. The EFL will be located in the Analytical Laboratory, which is a low-hazard facility as determined by its Safety Analysis Report (SAR). The U-Pu-Zr fuel will be prototypical of the fuel that will be used in the Integral Fast Reactor (IFR) Program. Approximately 150 U-Pu-Zr alloy pins will be fabricated within the facility. The pins will be processed, inspected, and finally placed into element jackets that have been preloaded with sodium in another facility. After settling, the elements will be transferred to the Fuels and Subassembly Storage Building (FASB) for closure welding and process completion. The purpose of this document is to evaluate the effects to the public and/or working personnel of any incident in the EFL, which would release radioactive contamination to the environment. Several types of probable incidents that could occur within the EFL will be addressed along with actions that will be taken to prevent their occurrence. The document will conclude with an analysis of the most probable design basis accident (DBA), its radiological impact, and also a short discussion of a proposed maximum hypothetical accident. (MHA).

  16. Harmonic Coupling Analysis of a Multi-Drive System with Slim DC-link Drive

    DEFF Research Database (Denmark)

    Yang, Feng; Kwon, Jun Bum; Blaabjerg, Frede

    2017-01-01

    One of the problems with slim dc-link adjustable speed drive is the difficulties to analyze the harmonic coupling when it is integrated into a multi-drive system. The traditional methods analyze this harmonic issue by neglecting the harmonic coupling, and base on the linear time-invariant methods....... Its disadvantages include the time consumption and large computer memory. This paper proposes to do harmonic analysis by using the harmonic state-space modeling method by using the linear time-periodic theory. By using the proposed model, the harmonic couplings, between dc-link and point of common...... coupling in different drives, are all analyzed in the multi-drive system. In the meantime, the effects of the small film dc-link capacitance and the nonlinear characteristic of the diode rectifier are considered. The detailed modeling procedure, the simulations and the lab experiment on a two-drive system...

  17. Comparative analysis of algorithms for compensation of nonlinear distortions in fibre-optic links

    Science.gov (United States)

    Burdin, V. A.; Bourdine, A. V.; Grigorov, I. V.

    2017-12-01

    We report the results of numerical modelling and comparative analysis of two algorithms for digital signal processing intended for signal demodulation in fibre-optic links (FOLs) operating in a nonlinear mode. The first algorithm is based on the use of nonlinear Schrödinger filters and the second one utilises the ‘reception in general with bit-by-bit decision making’ technique. It is found that the latter algorithm is more noiseproof, compared to the first one (with a SNR gain of about 0.5 dB), in single-channel fibre-optic links, and its operation does not require knowledge of the link parameters; therefore, the second algorithm can also be constructed for wavelength-division multiplexing systems.

  18. Functional analysis of the Helicobacter pullorum N-linked protein glycosylation system.

    Science.gov (United States)

    Jervis, Adrian J; Wood, Alison G; Cain, Joel A; Butler, Jonathan A; Frost, Helen; Lord, Elizabeth; Langdon, Rebecca; Cordwell, Stuart J; Wren, Brendan W; Linton, Dennis

    2018-01-11

    N-linked protein glycosylation systems operate in species from all three domains of life. The model bacterial N-linked glycosylation system from Campylobacter jejuni is encoded by pgl genes present at a single chromosomal locus. This gene cluster includes the pglB oligosaccharyltransferase responsible for transfer of glycan from lipid carrier to protein. Although all genomes from species of the Campylobacter genus contain a pgl locus, among the related Helicobacter genus only three evolutionarily related species (H. pullorum, H. canadensis and H. winghamensis) potentially encode N-linked protein glycosylation systems. Helicobacter putative pgl genes are scattered in five chromosomal loci and include two putative oligosaccharyltransferase-encoding pglB genes per genome. We have previously demonstrated the in vitro N-linked glycosylation activity of H. pullorum resulting in transfer of a pentasaccharide to a peptide at asparagine within the sequon (D/E)XNXS/T. In this study, we identified the first H. pullorum N-linked glycoprotein, termed HgpA. Production of histidine-tagged HgpA in the background of insertional knockout mutants of H. pullorum pgl/wbp genes followed by analysis of HgpA glycan structures demonstrated the role of individual gene products in the PglB1-dependent N-linked protein glycosylation pathway. Glycopeptide purification by zwitterionic-hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry identified six glycosites from five H. pullorum proteins, which was consistent with proteins reactive with a polyclonal antiserum generated against glycosylated HgpA. This study demonstrates functioning of a H. pullorum N-linked general protein glycosylation system. © The Author 2018. Published by Oxford University Press.

  19. Disclosure-Protected Inference with Linked Microdata Using a Remote Analysis Server

    Directory of Open Access Journals (Sweden)

    Chipperfield James O.

    2014-03-01

    Full Text Available Large amounts of microdata are collected by data custodians in the form of censuses and administrative records. Often, data custodians will collect different information on the same individual. Many important questions can be answered by linking microdata collected by different data custodians. For this reason, there is very strong demand from analysts, within government, business, and universities, for linked microdata. However, many data custodians are legally obliged to ensure the risk of disclosing information about a person or organisation is acceptably low. Different authors have considered the problem of how to facilitate reliable statistical inference from analysis of linked microdata while ensuring that the risk of disclosure is acceptably low. This article considers the problem from the perspective of an Integrating Authority that, by definition, is trusted to link the microdata and to facilitate analysts’ access to the linked microdata via a remote server, which allows analysts to fit models and view the statistical output without being able to observe the underlying linked microdata. One disclosure risk that must be managed by an Integrating Authority is that one data custodian may use the microdata it supplied to the Integrating Authority and statistical output released from the remote server to disclose information about a person or organisation that was supplied by the other data custodian. This article considers analysis of only binary variables. The utility and disclosure risk of the proposed method are investigated both in a simulation and using a real example. This article shows that some popular protections against disclosure (dropping records, rounding regression coefficients or imposing restrictions on model selection can be ineffective in the above setting.

  20. A guide to evaluating linkage quality for the analysis of linked data.

    Science.gov (United States)

    Harron, Katie L; Doidge, James C; Knight, Hannah E; Gilbert, Ruth E; Goldstein, Harvey; Cromwell, David A; van der Meulen, Jan H

    2017-10-01

    Linked datasets are an important resource for epidemiological and clinical studies, but linkage error can lead to biased results. For data security reasons, linkage of personal identifiers is often performed by a third party, making it difficult for researchers to assess the quality of the linked dataset in the context of specific research questions. This is compounded by a lack of guidance on how to determine the potential impact of linkage error. We describe how linkage quality can be evaluated and provide widely applicable guidance for both data providers and researchers. Using an illustrative example of a linked dataset of maternal and baby hospital records, we demonstrate three approaches for evaluating linkage quality: applying the linkage algorithm to a subset of gold standard data to quantify linkage error; comparing characteristics of linked and unlinked data to identify potential sources of bias; and evaluating the sensitivity of results to changes in the linkage procedure. These approaches can inform our understanding of the potential impact of linkage error and provide an opportunity to select the most appropriate linkage procedure for a specific analysis. Evaluating linkage quality in this way will improve the quality and transparency of epidemiological and clinical research using linked data. © The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association.

  1. Performance analysis of rain attenuation on earth-to-satellite microwave links design in Libya

    Science.gov (United States)

    Rafiqul Islam, Md; Hussein Budalal, Asma Ali; Habaebi, Mohamed H.; Badron, Khairayu; Fadzil Ismail, Ahmad

    2017-11-01

    Performances of earth-to-satellite microwave links operating in Ku, Ka, and V-bands are degraded by the environment and strongly attenuated by rain. Rain attenuation is the most significant consideration and challenge to design a reliable earth-to-satellite microwave links for these frequency bands. Hence, it is essential for satellite link designer to take into account rain fade margin accurately before system implementation. Rain rate is the main measured parameter to predict of rain attenuation. Rainfall statistical data measured and recorded in Libya for the period of 30 years are collected from 5 locations. The prediction methods require one minute integration time rain intensity. Therefore, collected data were analyzed and processed to convert into one–minute rain rate cumulative distribution in Libya. The model proposed by ITU-R is used to predict and investigate rain fade based on converted 1-minute rain rate data. Rain fade predicted at two locations are used for performance analysis in terms of link spectral efficiency and throughput. V-band downlink shows that 99.99% availability is possible in all the Southern part stations in Libya at 0.29 bps/Hz spectral efficiency and 20.74 Mbps throughput when 72 MHz transponder band width is used which is not feasible in Northern part. Results of this paper will be a very useful resource to design highly reliable earth-to-satellite communication links in Libya.

  2. Acoustic analysis in Mudejar-Gothic churches: Experimental results

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria. .

  3. Experimental Tritium Cleanup System availability analysis from 1984 to 1992

    Energy Technology Data Exchange (ETDEWEB)

    Cadwallader, L.C. [EG and G Idaho, Inc., Idaho Falls, ID (United States); Taylor, G.L. [Los Alamos National Lab., NM (United States)

    1993-05-01

    This report gives the availability percentage of the Experimental Tritium Cleanup System (ETC) at the Tritium Systems Test Assembly (TSTA), which is a fusion research and technology facility at the Los Alamos National Laboratory. The component failure reports, the numbers of components, and operating times or demands are all given in this report. Sample calculations of the failure rates obtained from these data are given in the appendices. While future fusion experiments might use different or more advanced means to detritiate room air, the analysis of this system gives a data point for an actual detritiation system. Such a data point can be extrapolated for comparison with fault tree results on system designs, or can be used in a Bayesian failure rate analysis for estimating reliability of a new type of system. The nine years of testing operations on TSTA`s ETC result in a reasonable average availability value of 92% for the maximal tritium release event. The failure rates for new systems are expected to be lower than for the TSTA ETC, since improvements will be made in the design of the room air detritiation system based on the TSTA system experiences. Nonetheless, these TSTA data should be useful for future fusion reactor design work and safety assessment tasks.

  4. Optical bandgap of semiconductor nanostructures: Methods for experimental data analysis

    Science.gov (United States)

    Raciti, R.; Bahariqushchi, R.; Summonte, C.; Aydinli, A.; Terrasi, A.; Mirabella, S.

    2017-06-01

    Determination of the optical bandgap (Eg) in semiconductor nanostructures is a key issue in understanding the extent of quantum confinement effects (QCE) on electronic properties and it usually involves some analytical approximation in experimental data reduction and modeling of the light absorption processes. Here, we compare some of the analytical procedures frequently used to evaluate the optical bandgap from reflectance (R) and transmittance (T) spectra. Ge quantum wells and quantum dots embedded in SiO2 were produced by plasma enhanced chemical vapor deposition, and light absorption was characterized by UV-Vis/NIR spectrophotometry. R&T elaboration to extract the absorption spectra was conducted by two approximated methods (single or double pass approximation, single pass analysis, and double pass analysis, respectively) followed by Eg evaluation through linear fit of Tauc or Cody plots. Direct fitting of R&T spectra through a Tauc-Lorentz oscillator model is used as comparison. Methods and data are discussed also in terms of the light absorption process in the presence of QCE. The reported data show that, despite the approximation, the DPA approach joined with Tauc plot gives reliable results, with clear advantages in terms of computational efforts and understanding of QCE.

  5. Acoustic analysis in Mudejar-Gothic churches: experimental results.

    Science.gov (United States)

    Galindo, Miguel; Zamarreño, Teófilo; Girón, Sara

    2005-05-01

    This paper describes the preliminary results of research work in acoustics, conducted in a set of 12 Mudejar-Gothic churches in the city of Seville in the south of Spain. Despite common architectural style, the churches feature individual characteristics and have volumes ranging from 3947 to 10 708 m3. Acoustic parameters were measured in unoccupied churches according to the ISO-3382 standard. An extensive experimental study was carried out using impulse response analysis through a maximum length sequence measurement system in each church. It covered aspects such as reverberation (reverberation times, early decay times), distribution of sound levels (sound strength); early to late sound energy parameters derived from the impulse responses (center time, clarity for speech, clarity, definition, lateral energy fraction), and speech intelligibility (rapid speech transmission index), which all take both spectral and spatial distribution into account. Background noise was also measured to obtain the NR indices. The study describes the acoustic field inside each temple and establishes a discussion for each one of the acoustic descriptors mentioned by using the theoretical models available and the principles of architectural acoustics. Analysis of the quality of the spaces for music and speech is carried out according to the most widespread criteria for auditoria.

  6. Non-Invasive Parameter Identification in Rotordynamics via Fluid Film Bearings: Linking Active Lubrication and Operational Modal Analysis

    DEFF Research Database (Denmark)

    Santos, Ilmar; Svendsen, Peter Kjær

    2017-01-01

    , enabling evaluation of the mechanical condition of the rotating machine. Using the lubricant fluid film as a non-invasive calibrated shaker is troublesome, once several transfer functions among mechanical, hydraulic and electronic components become necessary. In this framework the main original...... the rotor as a function of a suitable control signal. The servovalve input signal and the radial injection pressure are the two main parameters responsible for dynamically modifying the journal oil film pressure and generating active fluid film forces in controllable fluid film bearings. Such fluid film...... contribution of this paper is to show experimentally that the knowledge about the several transfer functions can be bypassed by using output-only identification techniques. The manuscript links controllable (active) lubrication techniques with operational modal analysis, allowing for in-situ parameter...

  7. solQTL: a tool for QTL analysis, visualization and linking to genomes at SGN database

    Directory of Open Access Journals (Sweden)

    van der Knaap Esther

    2010-10-01

    Full Text Available Abstract Background A common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL. Fine mapping QTLs requires several generations of backcrosses and analysis of large populations, which is time-consuming and costly effort. Furthermore, as entire genomes are being sequenced and an increasing amount of genetic and expression data are being generated, a challenge remains: linking phenotypic variation to the underlying genomic variation. To identify candidate genes and understand the molecular basis underlying the phenotypic variation of traits, bioinformatic approaches are needed to exploit information such as genetic map, expression and whole genome sequence data of organisms in biological databases. Description The Sol Genomics Network (SGN, http://solgenomics.net is a primary repository for phenotypic, genetic, genomic, expression and metabolic data for the Solanaceae family and other related Asterids species and houses a variety of bioinformatics tools. SGN has implemented a new approach to QTL data organization, storage, analysis, and cross-links with other relevant data in internal and external databases. The new QTL module, solQTL, http://solgenomics.net/qtl/, employs a user-friendly web interface for uploading raw phenotype and genotype data to the database, R/QTL mapping software for on-the-fly QTL analysis and algorithms for online visualization and cross-referencing of QTLs to relevant datasets and tools such as the SGN Comparative Map Viewer and Genome Browser. Here, we describe the development of the solQTL module and demonstrate its application. Conclusions solQTL allows Solanaceae researchers to upload raw genotype and phenotype data to SGN, perform QTL analysis and dynamically cross-link to relevant genetic, expression and genome annotations. Exploration and synthesis of the relevant data is expected to help facilitate identification of candidate genes

  8. Linking Integration and Housing Career: A Longitudinal Analysis of Immigrant Groups in Sweden

    OpenAIRE

    Turner, Lena Magnusson; Hedman, Lina

    2014-01-01

    ABSTRACT This study investigates the extent to which immigrant groups are integrated in the Stockholm region through an analysis of their housing careers. Housing conditions are linked to many important life course events, as well as to the resources and preferences of each individual family. Housing conditions influence integration, but factors related to integration can also be a cause of housing conditions. In the study, we take a truly longitudinal approach to housing careers by exploring...

  9. Experimental analysis of precursors to severe problem behavior.

    Science.gov (United States)

    Fritz, Jennifer N; Iwata, Brian A; Hammond, Jennifer L; Bloom, Sarah E

    2013-01-01

    Some individuals engage in both mild and severe forms of problem behavior. Research has shown that when mild behaviors precede severe behaviors (i.e., the mild behaviors serve as precursors), they can (a) be maintained by the same source of reinforcement as severe behavior and (b) reduce rates of severe behavior observed during assessment. In Study 1, we developed an objective checklist to identify precursors via videotaped trials for 16 subjects who engaged in problem behavior and identified at least 1 precursor for every subject. In Study 2, we conducted separate functional analyses of precursor and severe problem behaviors for 8 subjects, and obtained correspondence between outcomes in 7 cases. In Study 3, we evaluated noncontingent reinforcement schedule thinning plus differential reinforcement of alternative behavior to reduce precursors, increase appropriate behavior, and maintain low rates of severe behavior during 3 treatment analyses for 2 subjects. Results showed that this treatment strategy was effective for behaviors maintained by positive and negative reinforcement. © Society for the Experimental Analysis of Behavior.

  10. Experimental analysis of a new retarding field energy analyzer

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Yu-Xiang [Shanghai Institute of Mechanical and Electrical Engineering, No. 3888, Yuanjiang Road, Minhang District, Shanghai 201109 (China); Institute of Electronics, Chinese Academy of Sciences, No. 19, North 4th Ring Road West, Haidian District, Beijing 100190 (China); Liu, Shu-Qing; Li, Xian-Xia; Shen, Hong-Li; Huang, Ming-Guang [Institute of Electronics, Chinese Academy of Sciences, No. 19, North 4th Ring Road West, Haidian District, Beijing 100190 (China); Liu, Pu-Kun, E-mail: pkliu@pku.edu.cn [School of Electronics Engineering and Computer Science, Peking University, No. 5, Yiheyuan Road, Haidian District, Beijing 100871 (China)

    2015-06-11

    In this paper, a new compact retarding field energy analyzer (RFEA) is designed for diagnosing electron beams of a K-band space travelling-wave tube (TWT). This analyzer has an aperture plate to sample electron beams and a cylindrical electrode to overcome the defocusing effects. The front end of the analyzer constructed as a multistage depression collector (MDC) structure is intended to shape the field to prevent electrons from being accelerated to escape. The direct-current (DC) beams of the K-band space TWTs with the removing MDC can be investigated on the beam measurement system. The current density distribution of DC beams is determined by the analyzer, while the anode voltage and helix voltage of the TWTs are 7000 V and 6850 V, respectively. The current curve’s slope effect due to the reflection of secondary electrons on the copper collector of the analyzer is discussed. The experimental analysis shows this RFEA has a good energy resolution to satisfy the requirement of beam measurement. - Highlights: • A new retarding field energy analyzer (RFEA) is designed to diagnose the electron beam of a K-band space TWT. • The current density distribution of direct-current beam is determined. • The reflection effect of secondary electrons on the copper collector of the analyzer is discussed.

  11. Meta-analysis on brain representation of experimental dental pain.

    Science.gov (United States)

    Lin, C-S; Niddam, D M; Hsu, M-L

    2014-02-01

    Functional magnetic resonance imaging (fMRI) has been widely used for investigating the brain representation associated with dental pain evoked by pulpal electrical stimulation. However, because of the heterogeneity of experimental designs and the small sample size of individual studies, the common brain representation regarding dental pain has remained elusive. We used imaging meta-analysis to investigate six dental pain-related fMRI studies (n = 87) and tested 3 hypotheses: (1) Dental pain is associated with the 'core' pain-related network; (2) pain-related brain activation is somatotopically organized in the somatosensory cortex; and (3) dental pain is associated with the cognitive-affective network related to pain. Qualitative and quantitative meta-analyses revealed: (1) common activation of the core pain-related network, including the somatosensory cortex, the insula, and the cingulate cortex; (2) inconsistency in somatotopically organized activation of the primary somatosensory cortex; and (3) common activation in the dorsolateral prefrontal cortex, suggesting a role of re-appraisal and coping in the experience of dental pain. In conclusion, fMRI combined with pulpal stimulation can effectively evoke activity in the pain-related network. The dental pain-related brain representation disclosed the mechanisms of how sensory and cognitive-affective factors shape dental pain, which will help in the development of more effective customized methods for central pain control.

  12. Curved Track Analysis of FSO Link for Ground-to-Train Communications

    Directory of Open Access Journals (Sweden)

    R. Paudel

    2014-04-01

    Full Text Available In this work, a free space optical (FSO link for the ground-to-train (G2T-FSO communications is proposed. Analytical analysis is carried out for the curved rail tracks. We show that the transmitter divergence angle, the transmit power and the size of the concentration lens need to increase for the curved section of the rail track compared to the straight track. We derive the analytical expression for the received power level based on the link geometry for the case of the curved track In the worst case scenario when the curvature radius is 120 m, the transmit power at the optical base station (BS needs to increase by over 2 dB when the concentration lens radius is increased by 5 times. Analyses also show that the received power along the track increases with the curvature radius for the same transmit power and receiver optics illustrating the effect due to link geometry. Additionally, the signal-to-noise ratio (SNR and the bit error rate (BER performance of the system for the curved track with different curvature radii is analysed at data rates of 10 Mbps and 100 Mbps for an additive white Gaussian noise (AWGN channel showing a good agreement between the theoretical and the simulated BER. Finally, effect of scintillations on the G2T-FSO link performance is discussed.

  13. Dependence of Invadopodia Function on Collagen Fiber Spacing and Cross-Linking: Computational Modeling and Experimental Evidence

    OpenAIRE

    Enderling, Heiko; Alexander, Nelson R.; Clark, Emily S.; Branch, Kevin M.; Estrada, Lourdes; Crooke, Cornelia; Jourquin, Jérôme; Lobdell, Nichole; Zaman, Muhammad H.; Guelcher, Scott A.; Anderson, Alexander R. A.; Weaver, Alissa M.

    2008-01-01

    Invadopodia are subcellular organelles thought to be critical for extracellular matrix (ECM) degradation and the movement of cells through tissues. Here we examine invadopodia generation, turnover, and function in relation to two structural aspects of the ECM substrates they degrade: cross-linking and fiber density. We set up a cellular automaton computational model that simulates ECM penetration and degradation by invadopodia. Experiments with denatured collagen (gelatin) were used to calibr...

  14. Experimental stress analysis for materials and structures stress analysis models for developing design methodologies

    CERN Document Server

    Freddi, Alessandro; Cristofolini, Luca

    2015-01-01

    This book summarizes the main methods of experimental stress analysis and examines their application to various states of stress of major technical interest, highlighting aspects not always covered in the classic literature. It is explained how experimental stress analysis assists in the verification and completion of analytical and numerical models, the development of phenomenological theories, the measurement and control of system parameters under operating conditions, and identification of causes of failure or malfunction. Cases addressed include measurement of the state of stress in models, measurement of actual loads on structures, verification of stress states in circumstances of complex numerical modeling, assessment of stress-related material damage, and reliability analysis of artifacts (e.g. prostheses) that interact with biological systems. The book will serve graduate students and professionals as a valuable tool for finding solutions when analytical solutions do not exist.

  15. Experimental and numerical analysis for optimal design parameters ...

    Indian Academy of Sciences (India)

    Rajneesh Kaushal

    Finally, the relations established are confirmed experimentally to validate the models. The relations thus established are ... Additionally, the present study is among the first attempts to reveal the effect of humidity on the performance of falling film evaporator. .... and accuracies of instruments used. 2.2 Experimental procedure.

  16. Experimental and Numerical Analysis of Fracture Processes in Concrete

    NARCIS (Netherlands)

    Schlangen, H.E.J.G.

    1993-01-01

    A combined experimental and numerical approach is adopted to investigate fracture processes in concrete. The experimental programme focuses on the failure of concrete subjected to mixed mode I and II loading. The influence of shear load on the nucleation and propagation of cracks in concrete is

  17. Experimental Methods for the Analysis of Optimization Algorithms

    DEFF Research Database (Denmark)

    of solution quality, runtime and other measures; and the third part collects advanced methods from experimental design for configuring and tuning algorithms on a specific class of instances with the goal of using the least amount of experimentation. The contributor list includes leading scientists...

  18. Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates.

    Science.gov (United States)

    Kostrhunova, H; Brabec, V

    2000-10-17

    The requirement for novel platinum antitumor drugs led to the concept of synthesis of novel platinum drugs based on targeting cisplatin to various carrier molecules. We have shown [Loskotova, H., and Brabec, V. (1999) Eur. J. Biochem. 266, 392-402] that attachment of DNA minor-groove-binder distamycin to cisplatin changes several features of DNA-binding mode of the parent platinum drug. Major differences comprise different conformational changes in DNA and a considerably higher interstrand cross-linking efficiency. The studies of the present work have been directed to the analysis of oligodeoxyribonucleotide duplexes containing single, site-specific adducts of platinum-distamycin conjugates. These uniquely modified duplexes were analyzed by Maxam-Gilbert footprinting, phase-sensitive gel electrophoresis bending assay and chemical probes of DNA conformation. The results have indicated that the attachment of distamycin to cisplatin mainly affects the sites involved in the interstrand cross-links so that these adducts are preferentially formed between complementary guanine and cytosine residues. This interstrand cross-link bends the helix axis by approximately 35 degrees toward minor groove, unwinds DNA by approximately 95 degrees and distorts DNA symmetrically around the adduct. In addition, CD spectra of restriction fragments modified by the cisplatin-distamycin conjugates have demonstrated that distamycin moiety in the interstrand cross-links of these compounds interacts with DNA. This interaction facilitates the formation of these adducts. Hence, the structural impact of the specific interstrand cross-link detected in this study deserves attention when biological behavior of cisplatin derivatives targeted by oligopeptide DNA minor-groove-binders is evaluated.

  19. Link Winds: A visual data analysis system and its application to the atmospheric ozone depletion problem

    Science.gov (United States)

    Jacobson, Allan S.; Berkin, Andrew L.

    1995-01-01

    The Linked Windows Interactive Data System (LinkWinds) is a prototype visual data exploration system resulting from a NASA Jet Propulsion Laboratory (JPL) program of research into the application of graphical methods for rapidly accessing, displaying, and analyzing large multi variate multidisciplinary data sets. Running under UNIX it is an integrated multi-application executing environment using a data-linking paradigm to dynamically interconnect and control multiple windows containing a variety of displays and manipulators. This paradigm, resulting in a system similar to a graphical spreadsheet, is not only a powerful method for organizing large amounts of data for analysis, but leads to a highly intuitive, easy-to-learn user interface. It provides great flexibility in rapidly interacting with large masses of complex data to detect trends, correlations, and anomalies. The system, containing an expanding suite of non-domain-specific applications, provides for the ingestion of a variety of data base formats and hard -copy output of all displays. Remote networked workstations running LinkWinds may be interconnected, providing a multiuser science environment (MUSE) for collaborative data exploration by a distributed science team. The system is being developed in close collaboration with investigators in a variety of science disciplines using both archived and real-time data. It is currently being used to support the Microwave Limb Sounder (MLS) in orbit aboard the Upper Atmosphere Research Satellite (UARS). This paper describes the application of LinkWinds to this data to rapidly detect features, such as the ozone hole configuration, and to analyze correlations between chemical constituents of the atmosphere.

  20. Research Directions for Cyber Experimentation: Workshop Discussion Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    DeWaard, Elizabeth [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Deccio, Casey [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fritz, David Jakob [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Tarman, Thomas D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories hosted a workshop on August 11, 2017 entitled "Research Directions for Cyber Experimentation," which focused on identifying and addressing research gaps within the field of cyber experimentation , particularly emulation testbeds . This report mainly documents the discussion toward the end of the workshop, which included research gaps such as developing a sustainable research infrastructure, exp anding cyber experimentation, and making the field more accessible to subject matter experts who may not have a background in computer science . Other gaps include methodologies for rigorous experimentation, validation, and uncertainty quantification, which , if addressed, also have the potential to bridge the gap between cyber experimentation and cyber engineering. Workshop attendees presented various ways to overcome these research gaps, however the main conclusion for overcoming these gaps is better commun ication through increased workshops, conferences, email lists, and slack chann els, among other opportunities.

  1. Short Circuit Ratio analysis of multi-infeed HVDC system with a VSC-HVDC link

    DEFF Research Database (Denmark)

    Liu, Yan; Chen, Zhe

    2011-01-01

    -infeed HVDC system stability has been analyzed a lot but the study on ESCR of this kind of system is still insufficient. This paper presents a calculation method for ESCR of the hybrid multi infeed HVDC system based on a simple two-infeed HVDC system model. The equivalent circuit of this system under short......As an important indicator of system stability, Short Circuit Ratio (SCR) is commonly used in power system analysis. For systems include HVDC link connection, the Effective SCR (ESCR) is mostly applied to indicate the strength of HVDC infeed bus. The contribution of VSC-HVDC link to multi...... circuit situation is firstly obtained based on the model. Then its Thevenin equivalent circuit is derived and system ESCR can be calculated. At last, simulation study verified that the calculated ESCR value under different cases can indicate the change of system stability....

  2. Ergodic Capacity Analysis of Free-Space Optical Links with Nonzero Boresight Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique

    2015-04-01

    A unified capacity analysis of a free-space optical (FSO) link that accounts for nonzero boresight pointing errors and both types of detection techniques (i.e. intensity modulation/ direct detection as well as heterodyne detection) is addressed in this work. More specifically, an exact closed-form expression for the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system is presented in terms of well-known elementary functions. Capitalizing on these new moments expressions, we present approximate and simple closedform results for the ergodic capacity at high and low SNR regimes. All the presented results are verified via computer-based Monte-Carlo simulations.

  3. Performance Analysis of FSO Links over Unified Gamma-Gamma Turbulence Channels

    KAUST Repository

    Ansari, Imran Shafique

    2015-05-01

    In this work, we present a unified performance analysis of a free-space optical (FSO) link that accounts for pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection as well as heterodyne detection). We, then, present unified exact closed-form expressions for various statistical characteristics of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system. We capitalize on these unified results to offer unified exact closed-form expressions for various performance metrics. Additionally, we derive the asymptotic results for all the expressions derived earlier in the high SNR regime in terms of simple elementary functions. We also derive new asymptotic expressions for the ergodic capacity in the low as well as high SNR regimes in terms of simple elementary functions via utilizing moments. All the presented results are verified via computer-based Monte-Carlo simulations. © 2015 IEEE.

  4. Self-replenishing ability of cross-linked low surface energy polymer films investigated by a complementary experimental-simulation approach

    Energy Technology Data Exchange (ETDEWEB)

    Esteves, A. C. C., E-mail: a.c.c.esteves@tue.nl, E-mail: g.dewith@tue.nl; Lyakhova, K.; Riel, J. M. van; With, G. de, E-mail: a.c.c.esteves@tue.nl, E-mail: g.dewith@tue.nl [Laboratory of Materials and Interface Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven (Netherlands); Ven, L. G. J. van der [Laboratory of Materials and Interface Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven (Netherlands); AkzoNobel, Automotive and Aerospace Coatings, Sassenheim (Netherlands); Benthem, R. A. T. M. van [Laboratory of Materials and Interface Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Eindhoven (Netherlands); DSM Ahead, Geleen (Netherlands)

    2014-03-28

    Nowadays, many self-healing strategies are available for recovering mechanical damage of bulk polymeric materials. The recovery of surface-dependent functionalities on polymer films is, however, equally important and has been less investigated. In this work we study the ability of low surface energy cross-linked poly(ester urethane) networks containing perfluorinated dangling chains to self-replenish their surface, after being submitted to repeated surface damage. For this purpose we used a combined experimental-simulation approach. Experimentally, the cross-linked films were intentionally damaged by cryo-microtoming to remove top layers and create new surfaces which were characterized by water Contact Angle measurements and X-Ray Photoelectron Spectroscopy. The same systems were simultaneously represented by a Dissipative Particles Dynamics simulation method, where the damage was modeled by removing the top film layers in the simulation box and replacing it by new “air” beads. The influence of different experimental parameters, such as the concentration of the low surface energy component and the molecular mobility span of the dangling chains, on the surface recovery is discussed. The combined approach reveals important details of the self-replenishing ability of damaged polymer films such as the occurrence of multiple-healing events, the self-replenishing efficiency, and the minimum “healing agent” concentration for a maximum recovery.

  5. Towards experimental validation of an analysis framework for morphing radiators

    Science.gov (United States)

    Bertagne, Christopher L.; Erickson, Lisa R.; Sheth, Rubik B.; Whitcomb, John D.; Hartl, Darren J.

    2016-04-01

    Thermal control is an important aspect of spacecraft design, particularly in the case of crewed vehicles, which must maintain a precise internal temperature at all times in spite of sometimes drastic variations in the external thermal environment and internal heat loads. The successes of the Space Shuttle and International Space Station programs have shown that this can be accomplished in Low Earth Orbit (LEO), however, crewed spacecraft traveling beyond LEO are expected to encounter more challenging thermal conditions with significant variations in both the heat rejection requirements and environment temperature. Such missions will require radiator systems with high turndown ratios, defined as the ratio between the maximum and minimum heat rejection rates achievable by the radiator system. Current radiators are only able to achieve turndown ratios of 3:1, far less than the 12:1 turndown ratio which is expected to be required on future missions. An innovative radiator concept, known as a morphing radiator, uses the temperature-induced shape change of shape memory alloy (SMA) materials to achieve a turndown ratio of at least 12:1. Predicting the thermal and structural behavior of SMA-based morphing radiators is challenging due to the presence of two-way thermomechanical coupling that has not been widely considered in the literature. Previous work has demonstrated the application of a technique known as a partitioned analysis procedure which can be used to simulate the behavior of morphing radiators. This work describes ongoing efforts to evaluate the physical accuracy of this approach by conducting validation studies. A detailed finite element model of a morphing radiator is developed and executed using the framework. Preliminary results show close agreement between the experimental data and model predictions, giving additional confidence in the partitioned approach.

  6. [The Waste Package Project. Final report, July 1, 1995--February 27, 1996]: Volume 2, Experimental verification of structural response of a flexible three-link hydraulic steel robot

    Energy Technology Data Exchange (ETDEWEB)

    Channarayapatna, Shashidhar S. [Univ. of Nevada, Las Vegas, NV (United States)

    1996-01-01

    This report presents experimental techniques for determining the static and dynamic response, in three dimensional space, of a flexible three-link hydraulic steel robot. The flexible robot was originally built under a grant from the Army Research Office (ARO) and has been the subject of a six year research project involving 12 graduate students and four faculty members. The research was continued under grant from the U.S. Department of Energy which is considering the use of robot in remote handling, placement and retrievability of H.L.N.W. canisters in geological formations. A series of static and dynamic experiments was conducted under two different loads at various angular positions of the robot links.

  7. Experimental and mathematical model of the interactions in the mixed culture of links in the “producer-consumer” cycle

    Science.gov (United States)

    Pisman, T. I.

    2009-07-01

    The paper presents a experimental and mathematical model of interactions between invertebrates (the ciliates Paramecium caudatum and the rotifers Brachionus plicatilis) in the "producer-consumer" aquatic biotic cycle with spatially separated components. The model describes the dynamics of the mixed culture of ciliates and rotifers in the "consumer" component, feeding on the mixed algal culture of the "producer" component. It has been found that metabolites of the algae Scenedesmus produce an adverse effect on the reproduction of the ciliates P. caudatum. Taking into account this effect, the results of investigation of the mathematical model were in qualitative agreement with the experimental results. In the "producer-consumer" biotic cycle it was shown that coexistence is impossible in the mixed culture of invertebrates of the "consumer" component. The ciliates P. caudatum are driven out by the rotifers B. plicatilis.

  8. Experimental and mathematical model of the interactions in the mixed culture of links in the "producer-consumer" cycle

    Science.gov (United States)

    Pisman, T. I.; Galayda, Ya. V.

    The paper presents experimental and mathematical model of interactions between invertebrates the ciliates Paramecium caudatum and the rotifers Brachionus plicatilis and algae Chlorella vulgaris and Scenedesmus quadricauda in the producer -- consumer aquatic biotic cycle with spatially separated components The model describes the dynamics of the mixed culture of ciliates and rotifers in the consumer component feeding on the mixed algal culture of the producer component It has been found that metabolites of the algae Scenedesmus produce an adverse effect on the reproduction of the ciliates P caudatum Taking into account this effect the results of investigation of the mathematical model were in qualitative agreement with the experimental results In the producer -- consumer biotic cycle it was shown that coexistence is impossible in the mixed algal culture of the producer component and in the mixed culture of invertebrates of the consumer component The ciliates P caudatum are driven out by the rotifers Brachionus plicatilis

  9. The alliance relationship analysis of international terrorist organizations with link prediction

    Science.gov (United States)

    Fang, Ling; Fang, Haiyang; Tian, Yanfang; Yang, Tinghong; Zhao, Jing

    2017-09-01

    Terrorism is a huge public hazard of the international community. Alliances of terrorist organizations may cause more serious threat to national security and world peace. Understanding alliances between global terrorist organizations will facilitate more effective anti-terrorism collaboration between governments. Based on publicly available data, this study constructed a alliance network between terrorist organizations and analyzed the alliance relationships with link prediction. We proposed a novel index based on optimal weighted fusion of six similarity indices, in which the optimal weight is calculated by genetic algorithm. Our experimental results showed that this algorithm could achieve better results on the networks than other algorithms. Using this method, we successfully digged out 21 real terrorist organizations alliance from current data. Our experiment shows that this approach used for terrorist organizations alliance mining is effective and this study is expected to benefit the form of a more powerful anti-terrorism strategy.

  10. The Preliminary Result and Analysis for BD Orbit Determination with Inter-satellite Link Data

    Directory of Open Access Journals (Sweden)

    SONG Xiaoyong

    2017-05-01

    Full Text Available The experimental satellite of BD navigation system has assembled inter-satellite link (ISL payloads and has obtained the real ISL observation data. The paper presents the preprocessing method of ISL and the POD method and result for Ka only observation and the combination Ka observation with L-band. It's showed that:the radial orbit error is less than 0.5 m with Ka only observation; the radial orbit error is less than 0.3 m with the observation by combining the Ka ISL with L-band data which has improved the orbit accuracy remarkably in contrast to L-band only data; the accuracy of calibrating device delay is better than 0.1 m。

  11. The Profitability of the Strategy Linking Fundamental, Portfolio and Technical Analysis on the Polish Capital Market

    Directory of Open Access Journals (Sweden)

    Flotyński Marcin

    2016-12-01

    Full Text Available In the article, several methods of taking investment decisions are described: a fundamental, portfolio, and technical analysis. They constitute different approaches which are convenient for different types of investors with various expectations and time horizons of their investments. The simultaneous combination of these three analyses is not popular. The aim of this study is to test the effectiveness of simultaneous use of a fundamental analysis, portfolio analysis, and technical analysis for shares quoted on the Warsaw Stock Exchange (WSE in 2000–2007. The research hypothesis is advanced that the concurrent-linked application of a fundamental, portfolio, and technical analysis brings better results than the separate use of these analyses. Models of capital market, such as CAPM and APT, have been used, as well as P/E ratio, Return on Equity (RoE, Relative Strength Index (RSI, and Exponential Moving Average (EMA. The combination of a financial analysis, technical indicators, and models of the capital market in order to invest on the stock exchange is author’s own method. In general, the survey has been carried out on the grounds of quantitative methods (financial analysis, regression model, and multi regression model and a comparative analysis. The results of the research have been used to create diversified portfolios on the WSE. It occurs that the concurrent use of the three analyses brings the highest rate of return of a portfolio.

  12. Experimental characterization of a 400  Gbit/s orbital angular momentum multiplexed free-space optical link over 120 m

    OpenAIRE

    Ren, Yongxiong; Wang, Zhe; Liao, Peicheng; Li, Long; Xie, Guodong; Huang, Hao; Zhao, Zhe; Yan, Yan; Ahmed, Nisar; Willner, Asher; Lavery, Martin P. J.; Ashrafi, Nima; Ashrafi, Solyman; Bock, Robert; Tur, Moshe

    2016-01-01

    We experimentally demonstrate and characterize the\\ud performance of a 400-Gbit/s orbital angular momentum\\ud (OAM) multiplexed free-space optical link over 120-\\ud meters on the roof of a building. Four OAM beams, each\\ud carrying a 100-Gbit/s QPSK channel are multiplexed and\\ud transmitted. We investigate the influence of channel\\ud impairments on the received power, inter-modal\\ud crosstalk among channels, and system power penalties.\\ud Without laser tracking and compensation systems, the\\...

  13. Simulink models for performance analysis of high speed DQPSK modulated optical link

    Energy Technology Data Exchange (ETDEWEB)

    Sharan, Lucky, E-mail: luckysharan@pilani.bits-pilani.ac.in; Rupanshi,, E-mail: f2011222@pilani.bits-pilani.ac.in; Chaubey, V. K., E-mail: vkc@pilani.bits-pilani.ac.in [EEE Department, BITS-Pilani, Rajasthan, 333031 (India)

    2016-03-09

    This paper attempts to present the design approach for development of simulation models to study and analyze the transmission of 10 Gbps DQPSK signal over a single channel Peer to Peer link using Matlab Simulink. The simulation model considers the different optical components used in link design with their behavior represented initially by theoretical interpretation, including the transmitter topology, Mach Zehnder Modulator(MZM) module and, the propagation model for optical fibers etc. thus allowing scope for direct realization in experimental configurations. It provides the flexibility to incorporate the various photonic components as either user-defined or fixed and, can also be enhanced or removed from the model as per the design requirements. We describe the detailed operation and need of every component model and its representation in Simulink blocksets. Moreover the developed model can be extended in future to support Dense Wavelength Division Multiplexing (DWDM) system, thereby allowing high speed transmission with N × 40 Gbps systems. The various compensation techniques and their influence on system performance can be easily investigated by using such models.

  14. Simulink models for performance analysis of high speed DQPSK modulated optical link

    Science.gov (United States)

    Sharan, Lucky; Rupanshi, Chaubey, V. K.

    2016-03-01

    This paper attempts to present the design approach for development of simulation models to study and analyze the transmission of 10 Gbps DQPSK signal over a single channel Peer to Peer link using Matlab Simulink. The simulation model considers the different optical components used in link design with their behavior represented initially by theoretical interpretation, including the transmitter topology, Mach Zehnder Modulator(MZM) module and, the propagation model for optical fibers etc. thus allowing scope for direct realization in experimental configurations. It provides the flexibility to incorporate the various photonic components as either user-defined or fixed and, can also be enhanced or removed from the model as per the design requirements. We describe the detailed operation and need of every component model and its representation in Simulink blocksets. Moreover the developed model can be extended in future to support Dense Wavelength Division Multiplexing (DWDM) system, thereby allowing high speed transmission with N × 40 Gbps systems. The various compensation techniques and their influence on system performance can be easily investigated by using such models.

  15. Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, Oliver; Keranen, Soile V.E.; Biggin, Mark; Knowles, David W.; Weber, Gunther H.; Hagen, Hans; Hamann, Bernd; Bethel, E. Wes

    2011-03-30

    Three-dimensional gene expression PointCloud data generated by the Berkeley Drosophila Transcription Network Project (BDTNP) provides quantitative information about the spatial and temporal expression of genes in early Drosophila embryos at cellular resolution. The BDTNP team visualizes and analyzes Point-Cloud data using the software application PointCloudXplore (PCX). To maximize the impact of novel, complex data sets, such as PointClouds, the data needs to be accessible to biologists and comprehensible to developers of analysis functions. We address this challenge by linking PCX and Matlab via a dedicated interface, thereby providing biologists seamless access to advanced data analysis functions and giving bioinformatics researchers the opportunity to integrate their analysis directly into the visualization application. To demonstrate the usefulness of this approach, we computationally model parts of the expression pattern of the gene even skipped using a genetic algorithm implemented in Matlab and integrated into PCX via our Matlab interface.

  16. A didactical structural model – linking analysis of teaching and analysis of educational media

    DEFF Research Database (Denmark)

    Graf, Stefan Ting

    1. Gap between general didactics and textbook/media research There seems to be a gap between general didactics (theory of teaching) and research in textbooks or educational media in general at least in the Nordic and German speaking countries. General didactic and their models seem to underestimate...... related questions (e.g. readability) without establishing a link to what is useful for the teacher’s tasks both on the level of preparation, practice and reflection, i.e. without an explicit theory of teaching. 2. Media in general didactics I will discuss the status of media in some current models...... of reflection in general didactics (Hiim/Hippe, Meyer, Klafki) and present a reconstruction of a didactical model of structure (Strukturmodel), whose counterstones are ‘intentional content’, ‘media/expression’ and ‘teaching method/activity’. The inclusion of media/expression in the model resumes a seemingly...

  17. Modeling and Performance Analysis of 10 Gbps Inter-satellite Optical Wireless Communication Link

    Science.gov (United States)

    Singh, Mehtab

    2017-12-01

    Free-space optical (FSO) communication has the advantages of two of the most predominant data transmission technologies - optical fiber communication and wireless communication. Most of the technical aspects of FSO are similar to that of optical fiber communication, with major difference in the information signal propagation medium which is free space in case of FSO rather than silica glass in optical fiber communication. One of the most important applications of FSO is inter-satellite optical wireless communication (IsOWC) links which will be deployed in the future in space. The IsOWC links have many advantages over the previously existing microwave satellite communication technologies such as higher bandwidth, lower power consumption, low cost of implementation, light size, and weight. In this paper, modeling and performance analysis of a 10-Gbps inter-satellite communication link with two satellites separated at a distance of 1,200 km has been done using OPTISYSTEM simulation software. Performance has been analyzed on the basis of quality factor, signal to noise ratio (SNR), and total power of the received signal.

  18. FLUORESCENT ANALYSIS OF PHOTOSYNTHETIC MICROBES AND POLYCYCLIC AROMATIC HYDROCARBONS LINKED TO OPTICAL REMOTE SENSING

    OpenAIRE

    Zhang, D.; Muller, J.-P.; Lavender, S.; Walton, D.; Dartnell, L. R.

    2012-01-01

    Fluorescence analysis, being a non-invasive technique, has become one of the most powerful and widely used techniques for microbiologists and chemists to study various types of sample from photosynthetic microbes to hydrocarbons. The work reported here focuses on experimental results of fluorescent features of photosynthetic microbial species (cyanobacteria) and also five different crude oil samples. The cyanobacteria samples were collected from the Baltic Sea at the end of July 2011...

  19. Experimental and numerical analysis of cylindrical straw drying

    Directory of Open Access Journals (Sweden)

    Goryl Wojciech

    2017-01-01

    Full Text Available The paper presents experimental and numerical results of the heat and mass transfer in a cylindrical bale of straw. The experimental measurements were made in a specialized stand of straw driers. Flue gasses, comes from straw combustion in the biomass boiler, are used as a drying medium. There were made measurements of humidity and temperature inside the cylindrical straw bale during the drying process. The results were used to prepare the drying rate curve. Moreover, data were used to validate the numerical model of straw drying. The numerical model was performed to depict the heat and mass transfer inside the straw bale. Furthermore, the model was used to optimize the drying process. The paper presents result of experimental and numerical drying rates of cylindrical straw bale and heat and mass transfer in its interior. As a result of the work numerical model was obtained. It satisfactorily describes the mechanisms inside the drying straw bale.

  20. Experimental Methods for the Analysis of Optimization Algorithms

    DEFF Research Database (Denmark)

    of solution quality, runtime and other measures; and the third part collects advanced methods from experimental design for configuring and tuning algorithms on a specific class of instances with the goal of using the least amount of experimentation. The contributor list includes leading scientists......, computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on different...

  1. Translating the link between social identity and health behavior into effective health communication strategies: An experimental application using antismoking advertisements.

    Science.gov (United States)

    Moran, Meghan Bridgid; Sussman, Steve

    2014-01-01

    Social identity is a construct that has been linked to health behavior. Yet, limited research has attempted to translate this relationship into health communication strategies. The current study addresses this gap by examining the efficacy of social identity targeting (constructing ads so that they target a specific group with which an individual identifies) to increase anti-cigarette smoking beliefs among adolescents. Two hundred and fifty one adolescents aged 12-15, randomly selected from a nationally representative sample, completed an online survey. Participants indicated which of 11 peer groups (determined in pre-testing) they most identified with. Each participant was then randomly assigned to view an ad that either did or did not target that group. One week later participants reported level of agreement with two key antismoking beliefs presented in the ad. Multiple regression analyses indicated that if an individual identified with the group targeted by the ad, antismoking beliefs were more strongly endorsed. Based on these findings, we conclude that social identity targeting has the potential to increase the effectiveness of antismoking messages and should be considered when designing antismoking campaigns.

  2. Genetic analysis of a kindred with X-linked mental handicap and retinitis pigmentosa

    Energy Technology Data Exchange (ETDEWEB)

    Aldred, M.A.; Dry, K.L.; Hardwick, L.J.; Teague, P.W.; Lester, D.H.; Brown, J.; Spowart, G.; Carothers, A.D.; Wright, A.F. [Western General Hospital, Edinburgh, Scotland (United Kingdom); Knight-Jones, E.B. [Univ. of Nottingham (United Kingdom)] [and others

    1994-11-01

    A kindred is described in which X-linked nonspecific mental handicap segregates together with retinitis pigmentosa. Carrier females are mentally normal but may show signs of the X-linked retinitis pigmentosa carrier state and become symptomatic in their later years. Analysis of polymorphic DNA markers at nine loci on the short arm of the X chromosome shows that no crossing-over occurs between the disease and Xp11 markers DXS255, TIMP, DXS426, MAOA, and DXS228. The 90% confidence limits show that the locus is in the Xp21-q21 region. Haplotype analysis is consistent with the causal gene being located proximal to the Xp21 loci DXS538 and 5{prime}-dystrophin on the short arm of the X chromosome. The posterior probability of linkage to the RP2 region of the X chromosome short arm (Xp11.4-p11.23) is .727, suggesting the possibility of a contiguous-gene-deletion syndrome. No cytogenetic abnormality has been identified. 33 refs., 2 figs., 2 tabs.

  3. Feasibility Analysis Of Free Space Earth To Satellite Optical Link In Tropical Region

    Directory of Open Access Journals (Sweden)

    Norhanis Aida M. Nor

    2012-01-01

    Full Text Available Free Space Optics (FSO becomes a great attention because of the chances in transmitting data up to 2.5Gbps. There are a lot of advantages offered by FSO such as easily deployment with saving time and cost and no electromagnetic interference. In spite of the advantages, FSO has an uncontrolled drawback which is highly sensitive to atmospheric phenomena because uses air as tranmission medium. Current studies and researches are only focusing on FSO terrestrial link with short path length and based on data from temperate region. Therefore, this paper is aiming to provide feasibility analysis of FSO link from earth to satellite especially Low Earth Orbit (LEO based on atmospheric data in tropical region. The analysis will include the losses from geometrical attenuation, absorption, scintillation, haze attenuation, and rain attenuation. ABSTRAK: Ruang Bebas Optik (Free Space Optics (FSO mendapat perhatian kerana kebolehannya memancarkan data pada kelajuan tinggi. Di sebalik kelebihannya, FSO amat sensitif terhadap fenomena atmosfera kerana ia menggunakan udara sebagai perantara transmisi. Penyelidikan dan kajian terkini hanya memfokus kepada jalinan darat FSO dengan kepanjangan jarak pendek dan bergantung kepada kawasan tenang.  Oleh itu, kertas ini menyasarkan untuk memberikan analisis kebolehlaksanaan  jalinan FSO dari bumi ke satelit terutamanya Orbit Rendah Bumi (Low Earth Orbit (LEO bergantung kepada data atmosfera di kawasan tropika. Analisa termasuklah kehilangannya akibat pengecilan geometri, penyerapan, kelipan, pelemahan jerebu dan pelemahan hujan.KEYWORDS:  feasibility; Free Space Optics; availability; atmospheric attenuation; beam divergence angle; elevation angle

  4. Linking trading ratio with TMDL (total maximum daily load) allocation matrix and uncertainty analysis.

    Science.gov (United States)

    Zhang, H X

    2008-01-01

    An innovative approach for total maximum daily load (TMDL) allocation and implementation is the watershed-based pollutant trading. Given the inherent scientific uncertainty for the tradeoffs between point and nonpoint sources, setting of trading ratios can be a contentious issue and was already listed as an obstacle by several pollutant trading programs. One of the fundamental reasons that a trading ratio is often set higher (e.g. greater than 2) is to allow for uncertainty in the level of control needed to attain water quality standards, and to provide a buffer in case traded reductions are less effective than expected. However, most of the available studies did not provide an approach to explicitly address the determination of trading ratio. Uncertainty analysis has rarely been linked to determination of trading ratio.This paper presents a practical methodology in estimating "equivalent trading ratio (ETR)" and links uncertainty analysis with trading ratio determination from TMDL allocation process. Determination of ETR can provide a preliminary evaluation of "tradeoffs" between various combination of point and nonpoint source control strategies on ambient water quality improvement. A greater portion of NPS load reduction in overall TMDL load reduction generally correlates with greater uncertainty and thus requires greater trading ratio. The rigorous quantification of trading ratio will enhance the scientific basis and thus public perception for more informed decision in overall watershed-based pollutant trading program. (c) IWA Publishing 2008.

  5. Network analysis of physics discussion forums and links to course success

    Science.gov (United States)

    Traxler, Adrienne; Gavrin, Andrew; Lindell, Rebecca

    2017-01-01

    Large introductory science courses tend to isolate students, with negative consequences for long-term retention in college. Many active learning courses build collaboration and community among students as an explicit goal, and social network analysis has been used to track the development and beneficial effects of these collaborations. Here we supplement such work by conducting network analysis of online course discussion forums in two semesters of an introductory physics class. Online forums provide a tool for engaging students with each other outside of class, and offer new opportunities to commuter or non-traditional students with limited on-campus time. We look for correlations between position in the forum network (centrality) and final course grades. Preliminary investigation has shown weak correlations in the very dense full-semester network, so we will consider reduced ''backbone'' networks that highlight the most consistent links between students. Future work and implications for instruction will also be discussed.

  6. Analysis of experimental data sets for local scour depth around ...

    African Journals Online (AJOL)

    The performance of soft computing techniques to analyse and interpret the experimental data of local scour depth around bridge abutment, measured at different laboratory conditions and environment, is presented. The scour around bridge piers and abutments is, in the majority of cases, the main reason for bridge failures.

  7. Experimental and theoretical resonator analysis of linear femtosecond dye lasers

    NARCIS (Netherlands)

    Castner, Edward; Korpershoek, J.J.; Wiersma, Douwe

    1990-01-01

    Experimental and theoretical results for a linear cavity, hybrid modelocked femtosecond dye laser are presented. This laser has improved insensitivity to angular misalignment of the cavity mirrors. Two novel linear resonator configurations are designed that allow for yet further improvements of

  8. Experimental Analysis and Model Validation of an Opaque Ventilated Facade

    DEFF Research Database (Denmark)

    López, F. Peci; Jensen, Rasmus Lund; Heiselberg, Per

    2012-01-01

    Natural ventilation is a convenient way of reducing energy consumption in buildings. In this study an experimental module of an opaque ventilated façade (OVF) was built and tested for assessing its potential of supplying free ventilation and air preheating for the building. A numerical model was ...

  9. Analytical and Experimental Vibration Analysis of a Faulty Gear System

    Science.gov (United States)

    Choy, F. K.; Braun, M. J.; Polyshchuk, V.; Zakrajsek, J. J.; Townsend, D. P.; Handschuh, R. F.

    1994-01-01

    A comprehensive analytical procedure was developed for predicting faults in gear transmission systems under normal operating conditions. A gear tooth fault model is developed to simulate the effects of pitting and wear on the vibration signal under normal operating conditions. The model uses changes in the gear mesh stiffness to simulate the effects of gear tooth faults. The overall dynamics of the gear transmission system is evaluated by coupling the dynamics of each individual gear-rotor system through gear mesh forces generated between each gear-rotor system and the bearing forces generated between the rotor and the gearbox structure. The predicted results were compared with experimental results obtained from a spiral bevel gear fatigue test rig at NASA Lewis Research Center. The Wigner-Ville distribution (WVD) was used to give a comprehensive comparison of the predicted and experimental results. The WVD method applied to the experimental results were also compared to other fault detection techniques to verify the WVD's ability to detect the pitting damage, and to determine its relative performance. Overall results show good correlation between the experimental vibration data of the damaged test gear and the predicted vibration from the model with simulated gear tooth pitting damage. Results also verified that the WVD method can successfully detect and locate gear tooth wear and pitting damage.

  10. Experimental Bifurcation Analysis By Control-based Continuation - Determining Stability’

    DEFF Research Database (Denmark)

    Bureau, Emil; Santos, Ilmar; Thomsen, Jon Juel

    2012-01-01

    stable and unstable equilibrium states. We present the ongoing work of developing and applying the control-based continuation method to an experimental mechanical test-rig, consisting of a harmonically forced nonlinear impact oscillator controlled by electromagnetic actuators. Furthermore we propose...

  11. Analysis of experimental data sets for local scour depth around ...

    African Journals Online (AJOL)

    2010-08-17

    Aug 17, 2010 ... This study sought to answer the following questions: Firstly, can data collected .... At the first stage of this study, 7 experimental data sets ...... di Milano, Piazza Leonardo da. Vinci 32, 20133, Milano, Italy. BALLIO F and ORSI E (2000) Time evaluation of scour around bridge abutments. Water Eng. Res.

  12. Experimental Analysis of Voicing Contrast in Igbo Linda Chinelo ...

    African Journals Online (AJOL)

    Ike Odimegwu

    Abstract. This study presents experimental evidence to support the two- way voicing contrast of Igbo stops and fricatives. It also focuses on the phonetic details of Igbo stops and fricatives. Digital recordings of the stops and fricatives were made at a sample rate of 44,100Hz and subsequently analysed in Praat. The study ...

  13. Experimental Analysis of Voicing Contrasts in Igbo | Nkamigbo ...

    African Journals Online (AJOL)

    This study presents experimental evidence to support the twoway voicing contrast of Igbo stops and fricatives. It also focuses on the phonetic details of Igbo stops and fricatives. Digital recordings of the stops and fricatives were made at a sample rate of 44,100Hz and subsequently analysed in Praat. The study looked into ...

  14. Experimental and numerical analysis for optimal design parameters ...

    Indian Academy of Sciences (India)

    Later, the response surface curves are studied using ANOVA. Finally, the relations established are confirmed experimentally to validate the models. The relations thus established are beneficent in furtherance of designing evaporators. Additionally, the presentstudy is among the first attempts to reveal the effect of humidity ...

  15. Constructing parapsychology : a discourse analysis of the accounts of experimental parapsychologists

    OpenAIRE

    Coelho, Claudia Carvalho De Matos Teixeira

    2005-01-01

    This thesis is concerned with parapsychology as a field of experimental science. It is based on the discourse analysis of interviews with experimental parapsychologists, in which they provide accounts of their field, their own research practices and experimental outcomes. Drawing on literature from the fields of parapsychology and social studies of science, experimental parapsychologists are characterised as having an asymmetrical standing within science. Whilst they share with ot...

  16. Analysis of a Combined Antenna Arrays and Reverse-Link Synchronous DS-CDMA System over Multipath Rician Fading Channels

    OpenAIRE

    Kim Yong-Seok; Whang Keum-Chan

    2005-01-01

    We present the BER analysis of antenna array (AA) receiver in reverse-link asynchronous multipath Rician channels and analyze the performance of an improved AA system which applies a reverse-link synchronous transmission technique (RLSTT) in order to effectively make a better estimation of covariance matrices at a beamformer-RAKE receiver. In this work, we provide a comprehensive analysis of user capacity which reflects several important factors such as the ratio of the specular component pow...

  17. application of covariance analysis to feed/ ration experimental data

    African Journals Online (AJOL)

    Prince Acheampong

    and εij - is a random error component (Smith, 1957). Regression and Correlation Analysis. A regression analysis was used in deriving an equation of the line which describes the shape of the relationship between initial weight and the weight gain. A correlation analysis was used to measure the closeness of the relationship ...

  18. An Experimental Test of a Causal Link between Problem-Solving Performance and Reproductive Success in Wild Great Tits

    Directory of Open Access Journals (Sweden)

    Laure Cauchard

    2017-09-01

    Full Text Available Recent studies have uncovered relationships between measures of various cognitive performances and proxies of fitness such as reproductive success in non-human animals. However, to better understand the evolution of cognition in the wild, we still have to determine the causality of these relationships and the underlying mechanisms. The cognitive ability of an individual may directly influence its ability to raise many and/or high quality young through for example its provisioning ability. Conversely, large and/or high quality broods may lead to high parental motivation to solve problems related to their care. To answer this question, we manipulated reproductive success through brood size and measured subsequent problem-solving performance in wild great tit parents. Our results show that brood size manipulation did not affect the probability to solve the task. Moreover, solver pairs fledged more young than non-solver pairs independently of brood size treatment in one of the two experimental years and they showed higher nestling provisioning rate in both years. Overall, it shows that problem-solving performance was not driven by motivation and suggest that problem-solvers may achieve higher fledging success through higher provisioning rates. Our study constitutes a first key step toward a mechanistic understanding of the consequences of innovation ability for individual fitness in the wild.

  19. Experimental analysis of chaos in under actuated electromechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Hernandez, H. G. [Universidad la Salle, Mexico, D.F. (Mexico); Alvarez Gallegos, Jaime [Instituto Politecnico Nacional (Mexico); Alvarez Gallegos Joaquin [Centro de Investigacion Cientifica y de Educacion Superior de Ensenada, Ensenada, Baja California (Mexico)

    2001-10-01

    An under actuated system is a kind of non-autonomous robotic system in which there are more links than actuators. The complexity of the dynamical behavior of these systems allows a wide variety of steady-state responses. The reconstruction of attractors based on time series obtained from measurements of one of the variables of a two-link, planar, under actuated robot called Pendubot, is developed. Time-delay coordinates, average mutual information, and percentage of false nearest neighbors' methods are used to reconstruct the invariant sets. It is shown that, under the action of a periodic torque, the Pendubot can display a variety of steady-state dynamics, including strange attractors. [Spanish] Un sistema electromecanico subactuado es un tipo de sistema robotico no autonomo que cuenta con mas eslabones que actuadores. La complejidad del comportamiento dinamico de estos sistemas permite una gran variedad de respuestas en estado estacionario. En este trabajo se desarrolla la reconstruccion de atractores basada en series de tiempo obtenidas a partir de mediciones de una de las variables de un robot planar de dos grados de libertad subactuado llamado Pendubot. A fin de reconstruir los conjuntos invariantes, se utilizan tecnica como retraso de coordenadas, promedio de informacion mutua y porcentaje de falsos vecinos cercanos. Se muestra que bajo la accion de un torque periodico, el Pendubot puede desplegar una variedad de comportamientos dinamicos en estado estacionario incluyendo atractores extranos.

  20. Spectroscopic Analysis of Neurotransmitters: A Theoretical and Experimental Raman Study

    Science.gov (United States)

    Alonzo, Matthew

    Surface-enhanced Raman spectroscopy (SERS) was applied to investigate the feasibility in the detection and monitoring of the dopamine (DA) neurotransmitter adsorbed onto silver nanoparticles (Ag NPs) at 10-11 molar, a concentration far below physiological levels. In addition, density functional theory (DFT) calculations were obtained with the Gaussian-09 analytical suite software to generate the theoretical molecular configuration of DA in its neutral, cationic, anionic, and dopaminequinone states for the conversion of computer-simulated Raman spectra. Comparison of theoretical and experimental results show good agreement and imply the presence of dopamine in all of its molecular forms in the experimental setting. The dominant dopamine Raman bands at 750 cm-1 and 795 cm-1 suggest the adsorption of dopaminequinone onto the silver nanoparticle surface. The results of this experiment give good insight into the applicability of using Raman spectroscopy for the biodetection of neurotransmitters.

  1. CFD analysis and experimental comparison of novel roof tile shapes

    Directory of Open Access Journals (Sweden)

    Michele Bottarelli

    2017-06-01

    Using an experimental rig, the air pressure difference and the volumetric flow rate between tiles have been measured for an existing Portoghese tile design over a range of pressures. Then, in order to understand the air flows under different conditions, a three-dimensional computational fluid dynamics (CFD model has been implemented to recreate the full geometry of the rig. The model was calibrated against the aforementioned experimental results, and run with boundary conditions simulating different wind directions. Even in the low velocities typical of average local wind patterns, the fluid dynamic problem remains complex because of the geometry of the gaps between the tiles. However, it has been possible to assess the coefficient of local head loss and then apply it in an analytical relationship between pressure drop and flow rate, taking into account the open area. The results have shown how the wind direction affects the air permeability and, therefore, important insights have been gathered for the design of novel tiles.

  2. Experimental and Mathematical Analysis of Multilayer Insulation below 80 K

    CERN Document Server

    Chorowski, M; Parente, C; Riddone, G

    2000-01-01

    The Large Hadron Collider [1], presently under construction at CERN, will make an extensive use of multilayer insulation system (MLI). The total surface to be insulated will be of about 80000 m2. A mathematical model has been developed to describe the heat flux through MLI from 80 K to 4.2 K. The total heat flux between the layers is the result of three distinct heat transfer modes: radiation, residual gas conduction and solid conduction. The mathematical model enables prediction of MLI behavior with regard to different MLI parameters, such as gas insulation pressure, number of layers and boundary temperatures. The calculated values have been compared to the experimental measurements carried out at CERN. Theoretical and experimental results revealed to be in good agreement, especially for insulation vacuum between 10-5 Pa and 10-3 Pa.

  3. Birefringence of cellotape: Jones representation and experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Belendez, Augusto; Frances, Jorge; Neipp, Cristian [Departamento de Fisica, Ingenieria de Sistemas y Teoria de la Senal, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain); Fernandez, Elena [Departamento de Optica, FarmacologIa y Anatomia, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain)], E-mail: a.belendez@ua.es

    2010-05-15

    In this paper, we analyse a simple experiment to study the effects of polarized light. A simple optical system composed of a polarizer, a retarder (cellotape) and an analyser is used to study the effect on the polarization state of the light which impinges on the setup. The optical system is characterized by means of a Jones matrix, and a simple procedure based on Jones vectors is used to obtain an expression for the intensity after the light passes through the optical system. The light intensity is measured by a photodetector and the expression obtained theoretically is experimentally validated. By fitting the experimental intensity data, the value of the retardation introduced by the retarder can also be obtained.

  4. An Experimental and Numerical Analysis of Puff Hydrodynamics

    Directory of Open Access Journals (Sweden)

    Saidi MS

    2014-12-01

    Full Text Available The permeability of a tobacco rod in a cigarette increases as it converts into char and ash in the coal. The hot coal introduces a significant resistance to the air flow when air passes through. Through a series of experiments, the cigarette burn line and burn rate, the centerline temperature, and the pressure drop were measured for continuous puffing conditions. The gas viscosity was calculated from the temperature distribution inside the cigarette and applying Sutherland's law. Then, the experimental setup was mathematically modeled from a commercially available CFD (Computational Fluid Dynamics code and, by matching the numerical and experimental results, the changes in coal and filter permeability during puffing were estimated. The numerical simulation successfully reproduced the results of experiments on the air flow through the coal, ventilation holes and paper wrapper.

  5. Experimental analysis of blast mitigation associated with water sheets

    Science.gov (United States)

    Zakrajsek, Andrew J.; Miklaszewski, Eric J.; Guildenbecher, Daniel R.; Son, Steven F.

    2012-03-01

    An explosion yielding a blast wave can cause catastrophic damage to a building and its personnel. This threat defines an immediate importance for understanding blast mitigation techniques via readily available materials. An unconfined mass of water in the form of a free flowing sheet has been experimentally tested and analyzed as a readily available mitigant. A single water sheet, with an approximate sheet thickness of 3 mm, was experimentally tested with an explosively driven shock tube at three different standoff distances. At the strongest shock strength considered, the water sheet decreased the peak overpressure of the blast wave by 80% and the impulse by 60%. Additionally, the peak overpressure transmitted through the water sheet was roughly constant regardless of standoff distance and explosive strength.

  6. Experimental and Quasi-Experimental Studies of Inquiry-Based Science Teaching: A Meta-Analysis

    Science.gov (United States)

    Furtak, Erin Marie; Seidel, Tina; Iverson, Heidi; Briggs, Derek C.

    2012-01-01

    Although previous meta-analyses have indicated a connection between inquiry-based teaching and improved student learning, the type of instruction characterized as inquiry based has varied greatly, and few have focused on the extent to which activities are led by the teacher or student. This meta-analysis introduces a framework for inquiry-based…

  7. The "Journal of the Experimental Analysis of Behavior" at Zero, Fifty, and One Hundred

    Science.gov (United States)

    Catania, A. Charles

    2008-01-01

    The experimental content areas represented in "JEAB" in its first volume (1958) and fifty 50 years later in Volume 87 are in many ways similar with regard to research on schedules of reinforcement, research with human subjects, and several other topics. Experimental analysis has not been displaced by quantitative analysis. Much less research on…

  8. Finite Element and Experimental Analysis of Function of Plastic Clips

    OpenAIRE

    Honarpardaz, Mohammad Mahdi

    2011-01-01

    The aim of this work is to investigate the function of plastic clips which are used to join different parts, during mounting and dismounting processes. The clips are made of POM and will be mounted on steel plates. The study is undertaken using experimental and numerical methods. In experiments, the mounting and dismounting forces are measured with respect to vertical displacement of the clips related to the plate. The numerical method is performed using structural implicit non-linear quasi-s...

  9. Experimental methods for the analysis of optimization algorithms

    CERN Document Server

    Bartz-Beielstein, Thomas; Paquete, Luis; Preuss, Mike

    2010-01-01

    In operations research and computer science it is common practice to evaluate the performance of optimization algorithms on the basis of computational results, and the experimental approach should follow accepted principles that guarantee the reliability and reproducibility of results. However, computational experiments differ from those in other sciences, and the last decade has seen considerable methodological research devoted to understanding the particular features of such experiments and assessing the related statistical methods. This book consists of methodological contributions on diffe

  10. Experimental analysis of injection characteristics using biodiesel fuel

    OpenAIRE

    Kegl, Breda; Hribernik, Aleš

    2012-01-01

    This paper deals with injection characteristics using different fuels at different fuel temperatures. The fuels under consideration are neat biodiesel from rapeseed oil and some blends with diesel as well as neat mineral diesel D2. The fuel and fuel temperature influences are investigated experimentally in the mechanically controlled diesel fuel injection M system. At first, attention is focused on the injection characteristics, especially on fuelling, mean injection rate, mean injection pres...

  11. [Experimental analysis of finishing lines in ceramometal restorations].

    Science.gov (United States)

    Gascón, F; Gil, J A; Fons, A; Badal, R

    1990-11-01

    The preparation is the first step of any tooth reconstruction. The biological integration of the protesis is depending on the marginal adaptation (finish line of the preparation), occlusal adaptation (occlusal reduction), longevity of the restoration (retention and luting) and esthetics. The effect the two finish line of the preparation is studied using experimental design. In porcelain-fused-to-metal the finish line of the preparation in chanfer is superior at the beveled shoulder, because proportioning better marginal adaptation.

  12. The Role of Emotions on Risk Preferences : An Experimental Analysis

    OpenAIRE

    Conte, Anna; Levati, M. Vittoria; Nardi, Chiara

    2013-01-01

    In the last decades, there has been a large volume of research showing that emotions do have relevant effects on decision-making. We contribute to this literature by experimentally investigating the impact of four specific emotional states - joviality, sadness, fear, and anger - on risk attitudes. In order to do so, we fit two models of behaviour under risk: the Expected Utility model (EU) and the Rank Dependent Expected Utility model (RDEU), assuming several functional forms of the weighting...

  13. Experimental facility for analysis of biomass combustion characteristics

    Directory of Open Access Journals (Sweden)

    Miljković Biljana M.

    2015-01-01

    Full Text Available The objective of the present article is to present an experimental facility which was designed and built at the Faculty of Technical Sciences in order to study the combustion of different sorts of biomass and municipal solid waste. Despite its apparent simplicity, direct combustion is a complex process from a technological point of view. Conventional combustion equipment is not designed for burning agricultural residues. Devices for agricultural waste combustion are still in the development phase, which means that adequate design solution is presently not available at the world market. In order to construct a boiler and achieve optimal combustion conditions, it is necessary to develop a mathematical model for biomass combustion. Experimental facility can be used for the collection of data necessary for detailed modelling of real grate combustor of solid biomass fuels. Due to the complexity of the grate combustion process, its mathematical models and simulation software tools must be developed and verified using experimental data. This work highlights the properties required for the laboratory facility designed for the examination of biomass combustion and discusses design and operational issues.

  14. Sensible Heat Transfer during Droplet Cooling: Experimental and Numerical Analysis

    Directory of Open Access Journals (Sweden)

    Emanuele Teodori

    2017-06-01

    Full Text Available This study presents the numerical reproduction of the entire surface temperature field resulting from a water droplet spreading on a heated surface, which is compared with experimental data. High-speed infrared thermography of the back side of the surface and high-speed images of the side view of the impinging droplet were used to infer on the solid surface temperature field and on droplet dynamics. Numerical reproduction of the phenomena was performed using OpenFOAM CFD toolbox. An enhanced volume of fluid (VOF model was further modified for this purpose. The proposed modifications include the coupling of temperature fields between the fluid and the solid regions, to account for transient heat conduction within the solid. The results evidence an extremely good agreement between the temporal evolution of the measured and simulated spreading factors of the considered droplet impacts. The numerical and experimental dimensionless surface temperature profiles within the solid surface and along the droplet radius, were also in good agreement. Most of the differences were within the experimental measurements uncertainty. The numerical results allowed relating the solid surface temperature profiles with the fluid flow. During spreading, liquid recirculation within the rim, leads to the appearance of different regions of heat transfer that can be correlated with the vorticity field within the droplet.

  15. Performance Analysis of Free-Space Optical Links Over Malaga (M) Turbulence Channels with Pointing Errors

    KAUST Repository

    Ansari, Imran Shafique

    2015-08-12

    In this work, we present a unified performance analysis of a free-space optical (FSO) link that accounts for pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection (IM/DD) as well as heterodyne detection). More specifically, we present unified exact closedform expressions for the cumulative distribution function, the probability density function, the moment generating function, and the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system, all in terms of the Meijer’s G function except for the moments that is in terms of simple elementary functions. We then capitalize on these unified results to offer unified exact closed-form expressions for various performance metrics of FSO link transmission systems, such as, the outage probability, the scintillation index (SI), the average error rate for binary and M-ary modulation schemes, and the ergodic capacity (except for IM/DD technique, where we present closed-form lower bound results), all in terms of Meijer’s G functions except for the SI that is in terms of simple elementary functions. Additionally, we derive the asymptotic results for all the expressions derived earlier in terms of Meijer’s G function in the high SNR regime in terms of simple elementary functions via an asymptotic expansion of the Meijer’s G function. We also derive new asymptotic expressions for the ergodic capacity in the low as well as high SNR regimes in terms of simple elementary functions via utilizing moments. All the presented results are verified via computer-based Monte-Carlo simulations.

  16. Linked linear mixed models: A joint analysis of fixation locations and fixation durations in natural reading.

    Science.gov (United States)

    Hohenstein, Sven; Matuschek, Hannes; Kliegl, Reinhold

    2017-06-01

    The complexity of eye-movement control during reading allows measurement of many dependent variables, the most prominent ones being fixation durations and their locations in words. In current practice, either variable may serve as dependent variable or covariate for the other in linear mixed models (LMMs) featuring also psycholinguistic covariates of word recognition and sentence comprehension. Rather than analyzing fixation location and duration with separate LMMs, we propose linking the two according to their sequential dependency. Specifically, we include predicted fixation location (estimated in the first LMM from psycholinguistic covariates) and its associated residual fixation location as covariates in the second, fixation-duration LMM. This linked LMM affords a distinction between direct and indirect effects (mediated through fixation location) of psycholinguistic covariates on fixation durations. Results confirm the robustness of distributed processing in the perceptual span. They also offer a resolution of the paradox of the inverted optimal viewing position (IOVP) effect (i.e., longer fixation durations in the center than at the beginning and end of words) although the opposite (i.e., an OVP effect) is predicted from default assumptions of psycholinguistic processing efficiency: The IOVP effect in fixation durations is due to the residual fixation-location covariate, presumably driven primarily by saccadic error, and the OVP effect (at least the left part of it) is uncovered with the predicted fixation-location covariate, capturing the indirect effects of psycholinguistic covariates. We expect that linked LMMs will be useful for the analysis of other dynamically related multiple outcomes, a conundrum of most psychonomic research.

  17. Analysis of mutations in Menkes and X-linked cutis laxa patients

    Energy Technology Data Exchange (ETDEWEB)

    Das, S.; Levinson, B.; Gitschier, J. [Univ. of California, San Francisco, CA (United States)] [and others

    1994-09-01

    Menkes disease is an X-linked disorder of copper metabolism. The complex clinical phenotype is attribute to a deficiency of copper-containing enzymes resulting from a defect in copper transport. X-linked cutis laxa (XLCL), a mild, connective tissues disease may also be an allele of Menkes disease. A gene for the Menkes disease locus (MNK) has been isolated and found to code for a copper-transportion ATPase. Deletions in this gene have been observed in only 15-20% of patients by Southern blot analysis. We have analysed the MNK gene for mutations by RT-PCR and chemical cleavage mismatch detection in a group of 12 patients with severe Menkes phenotype and who were normal by Southern analysis. Mutations were observed in ten patients, and in each case, a different, debilitating mutation was present. Mutations that resulted in splicing abnormalities, detected by RT-PCR alone, were observed in six patients and included two splice site changes, a nonsense mutation, a missense mutation, a small duplication and a small deletion. Chemical cleavage analysis of the remaining six patients revealed the presence of one nonsense mutation, two adjacent 5 bp deletions and one missense mutation. A valine/leucine polymorphism was also observed. These findings, combined with the prior observation of large deletions in {approx}15% of patients, suggest that Southern blot hybridization and RT-PCR will identify mutations in the majority of patients. To date, no mutations have been found in 4 XLCL patients in the MNK coding region by chemical cleavage. However in 2 patients Southern blot changes have been detected with a 5{prime} UTR probe, suggesting mutations affecting regulatory elements.

  18. Power-Aware Routing and Network Design with Bundled Links: Solutions and Analysis

    Directory of Open Access Journals (Sweden)

    Rosario G. Garroppo

    2013-01-01

    Full Text Available The paper deeply analyzes a novel network-wide power management problem, called Power-Aware Routing and Network Design with Bundled Links (PARND-BL, which is able to take into account both the relationship between the power consumption and the traffic throughput of the nodes and to power off both the chassis and even the single Physical Interface Card (PIC composing each link. The solutions of the PARND-BL model have been analyzed by taking into account different aspects associated with the actual applicability in real network scenarios: (i the time for obtaining the solution, (ii the deployed network topology and the resulting topology provided by the solution, (iii the power behavior of the network elements, (iv the traffic load, (v the QoS requirement, and (vi the number of paths to route each traffic demand. Among the most interesting and novel results, our analysis shows that the strategy of minimizing the number of powered-on network elements through the traffic consolidation does not always produce power savings, and the solution of this kind of problems, in some cases, can lead to spliting a single traffic demand into a high number of paths.

  19. Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation: An experimental investigation.

    Science.gov (United States)

    Kumar, Ashish; Alakarjula, Maija; Vanhoorne, Valérie; Toiviainen, Maunu; De Leersnyder, Fien; Vercruysse, Jurgen; Juuti, Mikko; Ketolainen, Jarkko; Vervaet, Chris; Remon, Jean Paul; Gernaey, Krist V; De Beer, Thomas; Nopens, Ingmar

    2016-07-30

    of kneading discs was found to be critical for achieving a uniform distribution of the granulation liquid, the granulation performance was hampered due to insufficient solid-liquid mixing capacity of the current kneading discs which is essential for wet granulation. Thus, a balance between material throughput and screw speed should be strived for in order to achieve a specific granulation time and solid-liquid mixing for high granulation yield. Additionally, more efforts are needed both in modification of the screw configuration as well as the geometry of the mixing elements to improve the mixing capacity of the twin-screw granulator. The results from the current experimental study improved the understanding regarding the interplay between granulation time and the axial and solid-liquid mixing responsible for the granulation performance in twin-screw wet granulation. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Experimental and finite element analysis of fracture criterion in ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    z o. (a) θ r. (b). Figure 5. (a) Creation of crack tip elements (3-D, 20-noded structural solid). (b) Determination of stress value at the node having maximum displacement. 6.4 Nonlinear analysis. Elastic-plastic finite element analysis can be considered as an extension of elastic by incorporating extra conditions pertaining to ...

  1. Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.

    Science.gov (United States)

    Mollah, Md Bazlur R; Ishikawa, Akira

    2011-06-01

    A previous genome-wide QTL study revealed many QTLs affecting postnatal body weight and growth in an intersubspecific backcross mouse population between the C57BL/6J (B6) strain and wild Mus musculus castaneus mice captured in the Philippines. Subsequently, several closely linked QTLs for body composition traits were revealed in an F(2) intercross population between B6 and B6.Cg-Pbwg1, a congenic strain on the B6 genetic background carrying the growth QTL Pbwg1 on proximal chromosome 2. However, no QTL affecting body weight has been duplicated in the F(2) population, except for mapping an overdominant QTL that causes heterosis of body weight. In this study, we developed 17 intersubspecific subcongenic strains with overlapping and nonoverlapping castaneus regions from the B6.Cg-Pbwg1 congenic strain in order to search for and genetically dissect QTLs affecting body weight into distinct closely linked loci. Phenotypic comparisons of several developed subcongenic strains with the B6 strain revealed that two closely linked but distinct QTLs that regulate body weight, named Pbwg1.11 and Pbwg1.12, are located on an 8.9-Mb region between D2Mit270 and D2Mit472 and on the next 3.6-Mb region between D2Mit205 and D2Mit182, respectively. Further analyses using F(2) segregating populations obtained from intercrosses between B6 and each of the two selected subcongenic strains confirmed the presence of these two body weight QTLs. Pbwg1.11 had an additive effect on body weight at 6, 10, and 13 weeks of age, and its castaneus allele decreased it. In contrast, the castaneus allele at Pbwg1.12 acted in a dominant fashion and surprisingly increased body weight at 6, 10, and 13 weeks of age despite the body weight of wild castaneus mice being 60% of that of B6 mice. These findings illustrate the complex genetic nature of body weight regulation and support the importance of subcongenic mouse analysis to dissect closely linked loci.

  2. A didactical structural model – linking analysis of teaching and analysis of educational media

    DEFF Research Database (Denmark)

    Graf, Stefan Ting

    2009-01-01

    1. Gap between general didactics and textbook/media research There seems to be a gap between general didactics (theory of teaching) and research in textbooks or educational media in general at least in the Nordic and German speaking countries. General didactic and their models seem to underestimate...... for teaching if the research or the analysis does not have an integrated concept of teaching? Concrete concepts of teaching could be very challenging for research serving both teacher education and media production. As a radical example for such a challenge I will present and discuss the concept of “Lehrkunst......” (Berg/Schulze) with the principles of exemplary content, genetic learning and dramaturgical teaching....

  3. Experimental Analysis of Reduced-Sized Coplanar Waveguide Transmission Lines

    Science.gov (United States)

    Ponchak, George E.

    2002-01-01

    An experimental investigation of the use of capacitive loading of coplanar waveguides to reduce their line length and, thus the size, of monolithic microwave integrated circuits is presented. The reduced sized coplanar waveguides are compared to unloaded transmission lines and to lumped element transmission line segments. The phase bandwidth, defined by 2 percent error in S(sub 21), and the return loss bandwidth, defined by a return loss greater than 15 dB, of coplanar waveguides reduced from 0 to 90 percent are compared, and the insertion loss as a function of the size reduction is presented.

  4. Experimental Analysis of Bisbenzocyclobutene Bonded Capacitive Micromachined Ultrasonic Transducers

    OpenAIRE

    Manwar, Rayyan; Chowdhury, Sazzadur

    2016-01-01

    Experimental measurement results of a 1.75 mm ? 1.75 mm footprint area Capacitive Micromachined Ultrasonic Transducer (CMUT) planar array fabricated using a bisbenzocyclobutene (BCB)-based adhesive wafer bonding technique has been presented. The array consists of 40 ? 40 square diaphragm CMUT cells with a cavity thickness of 900 nm and supported by 10 ?m wide dielectric spacers patterned on a thin layer of BCB. A 150 ?m wide one ?m thick gold strip has been used as the contact pad for gold wi...

  5. Economic analysis of the link between diet quality and health: Evidence from Kosovo.

    Science.gov (United States)

    Braha, Kushtrim; Cupák, Andrej; Pokrivčák, Ján; Qineti, Artan; Rizov, Marian

    2017-11-01

    We analyse the link between diet diversity, (which is a proxy of diet quality) and health outcomes measured by body-mass index (BMI) in a representative sample of Kosovar adults using household expenditure micro-data. Building on a household model of health production we devise a two-stage empirical strategy to estimate the determinants of diet diversity and its effect on BMI. Economic factors and demographic characteristics play an important role in the choice of balanced diets. Results from the BMI analysis support the hypothesis that diet diversity is associated with optimal BMI. One standard deviation increase in diet diversity leads to 2.3% increase in BMI of the underweight individuals and to 1.5% reduction in BMI of the obese individuals. The findings have important implications for food security policies aiming at enhancing the public health in Kosovo. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Performance analysis of stationary Hadamard matrix diffusers in free-space optical communication links

    Science.gov (United States)

    Burrell, Derek J.; Middlebrook, Christopher T.

    2017-08-01

    Wireless communication systems that employ free-space optical links in place of radio/microwave technologies carry substantial benefits in terms of data throughput, network security and design efficiency. Along with these advantages comes the challenge of counteracting signal degradation caused by atmospheric turbulence in free-space environments. A fully coherent laser source experiences random phase delays along its traversing path in turbulent conditions forming a speckle pattern and lowering the received signal-to-noise ratio upon detection. Preliminary research has shown that receiver-side speckle contrast may be significantly reduced and signal-to-noise ratio increased accordingly through the use of a partially coherent light source. While dynamic diffusers and adaptive optics solutions have been proven effective, they also add expense and complexity to a system that relies on accessibility and robustness for successful implementation. A custom Hadamard diffractive matrix design is used to statically induce partial coherence in a transmitted beam to increase signal-to-noise ratio for experimental turbulence scenarios. Atmospheric phase screens are generated using an open-source software package and subsequently loaded into a spatial light modulator using nematic liquid crystals to modulate the phase.

  7. CLIPZ: a database and analysis environment for experimentally determined binding sites of RNA-binding proteins.

    Science.gov (United States)

    Khorshid, Mohsen; Rodak, Christoph; Zavolan, Mihaela

    2011-01-01

    The stability, localization and translation rate of mRNAs are regulated by a multitude of RNA-binding proteins (RBPs) that find their targets directly or with the help of guide RNAs. Among the experimental methods for mapping RBP binding sites, cross-linking and immunoprecipitation (CLIP) coupled with deep sequencing provides transcriptome-wide coverage as well as high resolution. However, partly due to their vast volume, the data that were so far generated in CLIP experiments have not been put in a form that enables fast and interactive exploration of binding sites. To address this need, we have developed the CLIPZ database and analysis environment. Binding site data for RBPs such as Argonaute 1-4, Insulin-like growth factor II mRNA-binding protein 1-3, TNRC6 proteins A-C, Pumilio 2, Quaking and Polypyrimidine tract binding protein can be visualized at the level of the genome and of individual transcripts. Individual users can upload their own sequence data sets while being able to limit the access to these data to specific users, and analyses of the public and private data sets can be performed interactively. CLIPZ, available at http://www.clipz.unibas.ch, aims to provide an open access repository of information for post-transcriptional regulatory elements.

  8. Magnetic field profile analysis for gyrotron experimental investigation

    Science.gov (United States)

    Pagonakis, Ioannis Gr.; Avramidis, Konstantinos A.; Gantenbein, Gerd; Rzesnicki, Tomasz; Samartsev, Andrey; Jelonnek, John

    2017-03-01

    The external applied magnetic field plays a main role on the gyrotron operation. Even if the gyrotron design is optimized for the nominal magnetic profile, it is possible the performance to be better for an alternative one. This unexpected result can happen for several reasons, such as the manufacturing imperfections, the misalignment issues, and several unknown factors in gyrotron theory and design. The systematic experimental investigation of the gyrotron in different magnetic profiles is very important for the optimization of the gyrotron operation and for the better understanding of the gyrotron behavior. In this sense, an analytical approach for the definition of the appropriate magnetic profiles based on the beam characteristics instead of the coil currents definition is proposed for a systematic experimental study. Using this technique, operational maps in the space of the important magnetic profile parameters are developed, which are very useful for the characterization of the gyrotron performance. For the demonstration of this idea, the operational maps of the short-pulse prototype of the 170 GHz, 1 MW European ITER gyrotron project are presented.

  9. Experimental Investigation and Analysis of an Annular Pogo Accumulator

    Science.gov (United States)

    Peugeot, John; Schwarz, Jordan; Yang, H. Q.; Zoladz, Tom

    2011-01-01

    An experimental investigation was conducted on a scaled annular pogo accumulator for the Ares I Upper Stage. The test article was representative of the LO2 feedline and preliminary accumulator design, and included multiple designs of a perforated ring connecting the accumulator to the core feedline flow. The system was pulse tested in water over a range of pulse frequency and flow rates. Time dependent measurements of pressure at various locations in the test article were used to extract system compliance, inertance, and resistance. Preliminary results indicated a significant deviation from standard orifice flow theory and suggest a strong dependence on feedline average velocity. In addition, several CFD analyses were conducted to investigate the details of the time variant flow field. Both two-dimensional and three-dimensional simulations were performed with time varying boundary conditions used to represent system pulsing. The CFD results compared well with the sub-scale results and demonstrated the influence of feedline average velocity on the flow into and out of the accumulator. This paper presents updated results of the investigation including a parametric design space for determining resistance characteristics. Using the updated experimental results a new scaling relationship has been defined for shear flow over a cavity. A comparison of sub-scale and full scale CFD simulations provided early verification of the scaling of the fluid flowfield and resistance characteristics.

  10. The schism between experimental and applied behavior analysis: Is it real and who cares?

    Science.gov (United States)

    Poling, A; Picker, M; Grossett, D; Hall-Johnson, E; Holbrook, M

    1981-01-01

    This paper addresses the relationship between the experimental analysis of behavior and applied behavior analysis. Citation data indicate that across time the Journal of the Experimental Analysis of Behavior, and other experimental sources, have been referenced increasingly infrequently in the Journal of Applied Behavior Analysis, Behavior Therapy, and Behavior Research and Therapy. Such sources are now rarely cited in these journals, and never have been regularly referenced in Behavior Modification. Although their proper interpretation is far from certain, these data partially support recent suggestions that the experimental analysis of behavior and applied behavior analysis are largely separate, insular fields. A questionnaire, mailed to the editorial staffs of the Journal of the Experimental Analysis of Behavior and the Journal of Applied Behavior Analysis, was intended to gather further information about the alleged schism between the fields. Few respondents regularly read both journals, publish in both journals, or find both journals useful in their current research efforts. The majority of editors of both journals indicated that the fields were growing apart, although there was no consensus that this is harmful for behavior analysis. Most editors of the Journal of Applied Behavior Analysis reported that research published in the Journal of the Experimental Analysis of Behavior has decreased in value to applied researchers across time; most editors of the Journal of the Experimental Analysis of Behavior indicated that research published there has not changed in applied value. Several respondents commented at length concerning the relationship of experimental and applied behavior analysis. These comments, many of which appear in the article, reveal a marked plurality of views.

  11. The schism between experimental and applied behavior analysis: Is it real and who cares? 1

    Science.gov (United States)

    Poling, Alan; Picker, Mitchell; Grossett, Deborah; Hall-Johnson, Earl; Holbrook, Maurice

    1981-01-01

    This paper addresses the relationship between the experimental analysis of behavior and applied behavior analysis. Citation data indicate that across time the Journal of the Experimental Analysis of Behavior, and other experimental sources, have been referenced increasingly infrequently in the Journal of Applied Behavior Analysis, Behavior Therapy, and Behavior Research and Therapy. Such sources are now rarely cited in these journals, and never have been regularly referenced in Behavior Modification. Although their proper interpretation is far from certain, these data partially support recent suggestions that the experimental analysis of behavior and applied behavior analysis are largely separate, insular fields. A questionnaire, mailed to the editorial staffs of the Journal of the Experimental Analysis of Behavior and the Journal of Applied Behavior Analysis, was intended to gather further information about the alleged schism between the fields. Few respondents regularly read both journals, publish in both journals, or find both journals useful in their current research efforts. The majority of editors of both journals indicated that the fields were growing apart, although there was no consensus that this is harmful for behavior analysis. Most editors of the Journal of Applied Behavior Analysis reported that research published in the Journal of the Experimental Analysis of Behavior has decreased in value to applied researchers across time; most editors of the Journal of the Experimental Analysis of Behavior indicated that research published there has not changed in applied value. Several respondents commented at length concerning the relationship of experimental and applied behavior analysis. These comments, many of which appear in the article, reveal a marked plurality of views. PMID:22478543

  12. Molecular Infectious Disease Epidemiology: Survival Analysis and Algorithms Linking Phylogenies to Transmission Trees.

    Science.gov (United States)

    Kenah, Eben; Britton, Tom; Halloran, M Elizabeth; Longini, Ira M

    2016-04-01

    Recent work has attempted to use whole-genome sequence data from pathogens to reconstruct the transmission trees linking infectors and infectees in outbreaks. However, transmission trees from one outbreak do not generalize to future outbreaks. Reconstruction of transmission trees is most useful to public health if it leads to generalizable scientific insights about disease transmission. In a survival analysis framework, estimation of transmission parameters is based on sums or averages over the possible transmission trees. A phylogeny can increase the precision of these estimates by providing partial information about who infected whom. The leaves of the phylogeny represent sampled pathogens, which have known hosts. The interior nodes represent common ancestors of sampled pathogens, which have unknown hosts. Starting from assumptions about disease biology and epidemiologic study design, we prove that there is a one-to-one correspondence between the possible assignments of interior node hosts and the transmission trees simultaneously consistent with the phylogeny and the epidemiologic data on person, place, and time. We develop algorithms to enumerate these transmission trees and show these can be used to calculate likelihoods that incorporate both epidemiologic data and a phylogeny. A simulation study confirms that this leads to more efficient estimates of hazard ratios for infectiousness and baseline hazards of infectious contact, and we use these methods to analyze data from a foot-and-mouth disease virus outbreak in the United Kingdom in 2001. These results demonstrate the importance of data on individuals who escape infection, which is often overlooked. The combination of survival analysis and algorithms linking phylogenies to transmission trees is a rigorous but flexible statistical foundation for molecular infectious disease epidemiology.

  13. Molecular Infectious Disease Epidemiology: Survival Analysis and Algorithms Linking Phylogenies to Transmission Trees

    Science.gov (United States)

    Kenah, Eben; Britton, Tom; Halloran, M. Elizabeth; Longini, Ira M.

    2016-01-01

    Recent work has attempted to use whole-genome sequence data from pathogens to reconstruct the transmission trees linking infectors and infectees in outbreaks. However, transmission trees from one outbreak do not generalize to future outbreaks. Reconstruction of transmission trees is most useful to public health if it leads to generalizable scientific insights about disease transmission. In a survival analysis framework, estimation of transmission parameters is based on sums or averages over the possible transmission trees. A phylogeny can increase the precision of these estimates by providing partial information about who infected whom. The leaves of the phylogeny represent sampled pathogens, which have known hosts. The interior nodes represent common ancestors of sampled pathogens, which have unknown hosts. Starting from assumptions about disease biology and epidemiologic study design, we prove that there is a one-to-one correspondence between the possible assignments of interior node hosts and the transmission trees simultaneously consistent with the phylogeny and the epidemiologic data on person, place, and time. We develop algorithms to enumerate these transmission trees and show these can be used to calculate likelihoods that incorporate both epidemiologic data and a phylogeny. A simulation study confirms that this leads to more efficient estimates of hazard ratios for infectiousness and baseline hazards of infectious contact, and we use these methods to analyze data from a foot-and-mouth disease virus outbreak in the United Kingdom in 2001. These results demonstrate the importance of data on individuals who escape infection, which is often overlooked. The combination of survival analysis and algorithms linking phylogenies to transmission trees is a rigorous but flexible statistical foundation for molecular infectious disease epidemiology. PMID:27070316

  14. Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes.

    Science.gov (United States)

    Kozobolis, Vassilios; Gkika, Maria; Sideroudi, Haris; Tsaragli, Efthymia; Lydataki, Stylliani; Naoumidi, Irini; Giatromanolaki, Alexandra; Mikropoulos, Dimitrios; Teus, Miguel; Labiris, Georgios

    The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.

  15. Viscoelasticity of Axisymmetric Composite Structures: Analysis and Experimental Validation

    Science.gov (United States)

    2013-02-01

    analysis can be applied to composite pressure vessels, gun barrels, and flywheels . 15. SUBJECT TERMS viscoelasticity, creep, composite, gun barrel... flywheel 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 28 19a. NAME OF RESPONSIBLE PERSON Jerome T...method to study the viscoelastic behavior of thick-walled composite cylinders. The analysis can be applied to the design of flywheel machinery and

  16. Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP heterotrimeric complex.

    Directory of Open Access Journals (Sweden)

    Amy L Stiegler

    Full Text Available The heterotrimeric protein complex containing the integrin linked kinase (ILK, parvin, and PINCH proteins, termed the IPP complex, is an essential component of focal adhesions, where it interacts with many proteins to mediate signaling from integrin adhesion receptors. Here we conduct a biochemical and structural analysis of the minimal IPP complex, comprising full-length human ILK, the LIM1 domain of PINCH1, and the CH2 domain of α-parvin. We provide a detailed purification protocol for IPP and show that the purified IPP complex is stable and monodisperse in solution. Using small-angle X-ray scattering (SAXS, we also conduct the first structural characterization of IPP, which reveals an elongated shape with dimensions 120×60×40 Å. Flexibility analysis using the ensemble optimization method (EOM is consistent with an IPP complex structure with limited flexibility, raising the possibility that inter-domain interactions exist. However, our studies suggest that the inter-domain linker in ILK is accessible and we detect no inter-domain contacts by gel filtration analysis. This study provides a structural foundation to understand the conformational restraints that govern the IPP complex.

  17. InfoLink: analysis of Dutch broadcast news and cross-media browsing

    NARCIS (Netherlands)

    Morang, Jeroen; de Jong, Franciska M.G.; Ordelman, Roeland J.F.; van Hessen, Adrianus J.

    2005-01-01

    In this paper, a cross-media browsing demonstrator named InfoLink is described. InfoLink automatically links the content of Dutch broadcast news videos to related information sources in parallel collections containing text and/or video. Automatic segmentation, speech recognition and available

  18. Stability analysis and dynamic response of a DC-link module with a series voltage compensator

    DEFF Research Database (Denmark)

    Wang, Huai; Liu, Wenchao; Chung, Henry

    2013-01-01

    A DC-link module composed of a reduced value of DC-link capacitor and a series voltage compensator has been proposed. The voltage compensator processes the ripple voltage on the DC link and reactive power only, which can be implemented by low-voltage devices. The overall energy storage of the DC...

  19. Mental representation and mental practice: experimental investigation on the functional links between motor memory and motor imagery.

    Science.gov (United States)

    Frank, Cornelia; Land, William M; Popp, Carmen; Schack, Thomas

    2014-01-01

    Recent research on mental representation of complex action has revealed distinct differences in the structure of representational frameworks between experts and novices. More recently, research on the development of mental representation structure has elicited functional changes in novices' representations as a result of practice. However, research investigating if and how mental practice adds to this adaptation process is lacking. In the present study, we examined the influence of mental practice (i.e., motor imagery rehearsal) on both putting performance and the development of one's representation of the golf putt during early skill acquisition. Novice golfers (N = 52) practiced the task of golf putting under one of four different practice conditions: mental, physical, mental-physical combined, and no practice. Participants were tested prior to and after a practice phase, as well as after a three day retention interval. Mental representation structures of the putt were measured, using the structural dimensional analysis of mental representation. This method provides psychometric data on the distances and groupings of basic action concepts in long-term memory. Additionally, putting accuracy and putting consistency were measured using two-dimensional error scores of each putt. Findings revealed significant performance improvements over the course of practice together with functional adaptations in mental representation structure. Interestingly, after three days of practice, the mental representations of participants who incorporated mental practice into their practice regime displayed representation structures that were more similar to a functional structure than did participants who did not incorporate mental practice. The findings of the present study suggest that mental practice promotes the cognitive adaptation process during motor learning, leading to more elaborate representations than physical practice only.

  20. Mental representation and mental practice: experimental investigation on the functional links between motor memory and motor imagery.

    Directory of Open Access Journals (Sweden)

    Cornelia Frank

    Full Text Available Recent research on mental representation of complex action has revealed distinct differences in the structure of representational frameworks between experts and novices. More recently, research on the development of mental representation structure has elicited functional changes in novices' representations as a result of practice. However, research investigating if and how mental practice adds to this adaptation process is lacking. In the present study, we examined the influence of mental practice (i.e., motor imagery rehearsal on both putting performance and the development of one's representation of the golf putt during early skill acquisition. Novice golfers (N = 52 practiced the task of golf putting under one of four different practice conditions: mental, physical, mental-physical combined, and no practice. Participants were tested prior to and after a practice phase, as well as after a three day retention interval. Mental representation structures of the putt were measured, using the structural dimensional analysis of mental representation. This method provides psychometric data on the distances and groupings of basic action concepts in long-term memory. Additionally, putting accuracy and putting consistency were measured using two-dimensional error scores of each putt. Findings revealed significant performance improvements over the course of practice together with functional adaptations in mental representation structure. Interestingly, after three days of practice, the mental representations of participants who incorporated mental practice into their practice regime displayed representation structures that were more similar to a functional structure than did participants who did not incorporate mental practice. The findings of the present study suggest that mental practice promotes the cognitive adaptation process during motor learning, leading to more elaborate representations than physical practice only.

  1. Experimental demonstration of bidirectional up to 40 Gbit/s QPSK coherent free-space optical communication link over ∼1 km

    Science.gov (United States)

    Feng, Xianglian; Wu, Zhihang; Wang, Tianshu; Zhang, Peng; Li, Xiaoyan; Jiang, Huilin; Su, Yuwei; He, Hongwei; Wang, Xiaoyan; Gao, Shiming

    2018-03-01

    Advanced multi-level modulation formats have shown their great potential in high-speed and high-spectral-efficiency optical communications. Using quadrature phase-shift keying (QPSK) modulation format for free-space optical (FSO) communication, a bidirectional high-speed FSO transmission link with the bit rates of up to 40 Gbit/s over ∼1 km, between two buildings in the campus of Changchun University of Science and Technology, Changchun, China, is experimentally demonstrated cooperating by capture and tracking systems. The eye-diagrams and constellation diagrams of the transmitted QPSK signals are clearly observed. By comparing the bit error rate (BER) curves before and after transmission, one can find that the receiving powers are both less than -16.5 dBm for the forward and backward transmissions of the bidirectional 20, 30, and 40 Gbit/s FSO links, and their power penalties due to the phase fluctuation of the atmospheric channel are both less than 2.6 dB, at the BER of 3.8 ×10-3.

  2. Experimental And FE Analysis Of Eccentric Loaded Symmetrical And Unsymmetrical Bolted Joint With Bolt Pretension

    OpenAIRE

    Pranav R. Pimpalkar; Prof. S. D. Khamankar

    2014-01-01

    This paper presents experimental and FE analysis of eccentric loaded bolted joint under symmetric and unsymmetrical bolt system with consider bolt pretension. A cad model of a bolted joint has been developed using modeling software PROE5.0 and FE analysis was carried out by using ANSYSWORKBENCH12.0.stress analysis has been carried out by varying bolt pattern of bolted joint for predict maximum heavily loaded bolt. Experimental work was conducted to measure maximum shear strengt...

  3. Theoretical and experimental performance analysis for cold trap design

    Energy Technology Data Exchange (ETDEWEB)

    Hemanath, M.G., E-mail: hemanath@igcar.gov.i [Fast Reactor Technology Group, Indira Gandhi Center for Atomic Research, Kalpakkam (India); Meikandamurthy, C.; Kumar, A. Ashok; Chandramouli, S.; Rajan, K.K.; Rajan, M.; Vaidyanathan, G.; Padmakumar, G.; Kalyanasundaram, P.; Raj, Baldev [Fast Reactor Technology Group, Indira Gandhi Center for Atomic Research, Kalpakkam (India)

    2010-10-15

    Cold trap is a purification unit used in sodium system of FBR's for maintaining the oxygen/hydrogen level in sodium within acceptable limits. It works on the principle of crystallization and precipitation of oxides/hydrides of sodium in a wire mesh, when the temperature of sodium is reduced below the saturation temperature. The cold traps presently used have lower effectiveness and get plugged prematurely. The plugged cold traps are cleaned and then put back into service. Frequent cleaning of cold trap results in the long down time of the sodium system. New design of cold trap has been conceived to overcome the above problems. The mathematical modeling for the new design was carried out and validated with experimentally tested results for its effectiveness. This paper shares the experience gained on the new design of cold trap for FBR's.

  4. Two-channel analysis of QUELL experimental results

    CERN Document Server

    Bottura, L; Rosso, C

    2000-01-01

    We have improved the model presently used in the thermo-hydraulic code Gandalf, adapting it to cable-in-conduit conductors with central cooling channel such as those developed for the model coils of ITER. In particular the helium flow in an arbitrary number of parallel channels have now independent velocity and thermodynamic state (pressure and temperature). We demonstrate the capability of the new model by means of comparison to measurements taken during the QUELL experiment in SULTAN. We compare in particular data on heat slug at zero current and field in a broad range of energy inputs, as well as data on quench propagation, to simulation results obtained with the single channel approximation and the newly implemented two-channel model. The latter achieves significantly better agreement with experimental data, in particular in the case of slow heating transients such as in heat slug propagation tests. (10 refs).

  5. Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

    Science.gov (United States)

    Tjalsma, Harold; Laarakkers, Coby M M; van Swelm, Rachel P L; Theurl, Milan; Theurl, Igor; Kemna, Erwin H; van der Burgt, Yuri E M; Venselaar, Hanka; Dutilh, Bas E; Russel, Frans G M; Weiss, Günter; Masereeuw, Rosalinde; Fleming, Robert E; Swinkels, Dorine W

    2011-03-08

    The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1) and its paralogue Hepcidin-2 (Hep-2) at the peptide level. To this purpose, Fourier transform ion cyclotron resonance (FTICR) and tandem-MS was used for hepcidin identification, after which a time-of-flight (TOF) MS-based methodology was exploited to routinely determine Hep-1 and -2 levels in mouse serum and urine. This method was biologically validated by hepcidin assessment in: i) 3 mouse strains (C57Bl/6; DBA/2 and BABL/c) upon stimulation with intravenous iron and LPS, ii) homozygous Hfe knock out, homozygous transferrin receptor 2 (Y245X) mutated mice and double affected mice, and iii) mice treated with a sublethal hepatotoxic dose of paracetamol. The results showed that detection of Hep-1 was restricted to serum, whereas Hep-2 and its presumed isoforms were predominantly present in urine. Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains. Serum Hep-1 was decreased in all three hemochromatosis models, being lowest in the double affected mice. Serum Hep-1 levels correlated with liver hepcidin-1 gene expression, while acute liver damage by paracetamol depleted Hep-1 from serum. Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation. In conclusion, Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators, and their measurement can now be implemented in experimental mouse models to provide novel insights in post-transcriptional regulation, hepcidin function, and kinetics.

  6. Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

    Directory of Open Access Journals (Sweden)

    Harold Tjalsma

    Full Text Available The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1 and its paralogue Hepcidin-2 (Hep-2 at the peptide level. To this purpose, Fourier transform ion cyclotron resonance (FTICR and tandem-MS was used for hepcidin identification, after which a time-of-flight (TOF MS-based methodology was exploited to routinely determine Hep-1 and -2 levels in mouse serum and urine. This method was biologically validated by hepcidin assessment in: i 3 mouse strains (C57Bl/6; DBA/2 and BABL/c upon stimulation with intravenous iron and LPS, ii homozygous Hfe knock out, homozygous transferrin receptor 2 (Y245X mutated mice and double affected mice, and iii mice treated with a sublethal hepatotoxic dose of paracetamol. The results showed that detection of Hep-1 was restricted to serum, whereas Hep-2 and its presumed isoforms were predominantly present in urine. Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains. Serum Hep-1 was decreased in all three hemochromatosis models, being lowest in the double affected mice. Serum Hep-1 levels correlated with liver hepcidin-1 gene expression, while acute liver damage by paracetamol depleted Hep-1 from serum. Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation. In conclusion, Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators, and their measurement can now be implemented in experimental mouse models to provide novel insights in post-transcriptional regulation, hepcidin function, and kinetics.

  7. Mass Spectrometry Analysis of Hepcidin Peptides in Experimental Mouse Models

    Science.gov (United States)

    van Swelm, Rachel P. L.; Theurl, Milan; Theurl, Igor; Kemna, Erwin H.; van der Burgt, Yuri E. M.; Venselaar, Hanka; Dutilh, Bas E.; Russel, Frans G. M.; Weiss, Günter; Masereeuw, Rosalinde; Fleming, Robert E.; Swinkels, Dorine W.

    2011-01-01

    The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1) and its paralogue Hepcidin-2 (Hep-2) at the peptide level. To this purpose, fourier transform ion cyclotron resonance (FTICR) and tandem-MS was used for hepcidin identification, after which a time-of-flight (TOF) MS-based methodology was exploited to routinely determine Hep-1 and -2 levels in mouse serum and urine. This method was biologically validated by hepcidin assessment in: i) 3 mouse strains (C57Bl/6; DBA/2 and BABL/c) upon stimulation with intravenous iron and LPS, ii) homozygous Hfe knock out, homozygous transferrin receptor 2 (Y245X) mutated mice and double affected mice, and iii) mice treated with a sublethal hepatotoxic dose of paracetamol. The results showed that detection of Hep-1 was restricted to serum, whereas Hep-2 and its presumed isoforms were predominantly present in urine. Elevations in serum Hep-1 and urine Hep-2 upon intravenous iron or LPS were only moderate and varied considerably between mouse strains. Serum Hep-1 was decreased in all three hemochromatosis models, being lowest in the double affected mice. Serum Hep-1 levels correlated with liver hepcidin-1 gene expression, while acute liver damage by paracetamol depleted Hep-1 from serum. Furthermore, serum Hep-1 appeared to be an excellent indicator of splenic iron accumulation. In conclusion, Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators, and their measurement can now be implemented in experimental mouse models to provide novel insights in post-transcriptional regulation, hepcidin function, and kinetics. PMID:21408141

  8. Experimental burn plot trial in the Kruger National Park: history, experimental design and suggestions for data analysis

    Directory of Open Access Journals (Sweden)

    R. Biggs

    2003-12-01

    Full Text Available The experimental burn plot (EBP trial initiated in 1954 is one of few ongoing long-termfire ecology research projects in Africa. The trial aims to assess the impacts of differentfire regimes in the Kruger National Park. Recent studies on the EBPs have raised questions as to the experimental design of the trial, and the appropriate model specificationwhen analysing data. Archival documentation reveals that the original design was modified on several occasions, related to changes in the park's fire policy. These modifications include the addition of extra plots, subdivision of plots and changes in treatmentsover time, and have resulted in a design which is only partially randomised. The representativity of the trial plots has been questioned on account of their relatively small size,the concentration of herbivores on especially the frequently burnt plots, and soil variation between plots. It is suggested that these factors be included as covariates inexplanatory models or that certain plots be excluded from data analysis based on resultsof independent studies of these factors. Suggestions are provided for the specificationof the experimental design when analysing data using Analysis of Variance. It is concluded that there is no practical alternative to treating the trial as a fully randomisedcomplete block design.

  9. Quantitative software analysis of ultrasonographic textures in experimental testicular torsion.

    Science.gov (United States)

    Aslan, Mustafa; Kucukaslan, Ibrahim; Mulazimoglu, Serkan; Soyer, Tutku; Şenyücel, Mine; Çakmak, Murat; Scholbach, Jakob; Aslan, Selim

    2013-04-01

    Ultrasonography (US) has high diagnostic value in testicular torsion but is vulnerable to several potential errors, especially in the early period. Echotexture (ETX) analysis software provides a numerical expression of B-mode images and allows quantitative evaluation of blood flow due to ischemic damage using power Doppler US (PDUS) analysis. Our aim in this study was to determine the diagnostic value and effective parameters of EXT analysis software in the early period of torsion using B-mode and PDUS images. In this study, eight rats were used. Following anesthesia, the right testis was rotated to a 1080-degree counterclockwise position whereas the left testis was left in place to have a control group. B-mode and PDUS images of both sides were recorded with a portable US device immediately (0 hour) and 1 and 2 hours after torsion. The B-mode images were analyzed in terms of gradient, homogeneity, and contrast using the BS200pro software (BAB Digital Imaging System 2007, Ankara, Turkey). Intensity (I)-red and area (A)-red values were measured on PDUS images with the Pixelflux (Version 1.0, Chameleon-Software, Leipzig, Germany). The data were evaluated by the Mann-Whitney U and Wilcoxon tests. Data from B-mode US image EXT analysis showed no significant difference between the right and left testicles in 0 to 2 hours (p > 0.05). The values obtained from PDUS analysis (I-red and A-red) significantly decreased at the testicular torsion side at the end of the second hour (p 0.05) whereas the flow was significantly lower at 2 hours (p analysis. Georg Thieme Verlag KG Stuttgart · New York.

  10. Design and analysis of eccentrically braced steel frames with vertical links using shape memory alloys

    Science.gov (United States)

    Massah, Saeed Reza; Dorvar, Hosein

    2014-10-01

    In recent years, the philosophy behind traditional methods by which structures were designed to withstand natural disasters has gone through major changes. Shape memory alloys (SMAs) are characterized by their superelastic behavior, which enables them to recover their original shape after experiencing large deformations. This characteristic provides an ideal reversibility capacity that can be used in the passive control of buildings exposed to earthquakes. This article has attempted to identify the effects of changing the hysteretic characteristics of SMA materials when they are used as passive control systems in eccentric bracing frames. By evaluating the numerical analysis results obtained from the modeling of an experimental sample and the modeling of the proposed EBF system, the accuracy of the above-stated notion was confirmed. Moreover, the results that pertain to the nonlinear pushover analysis, time-history dynamic analysis and seismic damage analysis of eccentric steel bracing frames of 4-, 9- and 14-story structures indicate that the use of SMA superelastic materials, in addition to effectively improving their ductility, stiffness and lateral strength, provides an excellent reversibility capacity, which considerably reduces both the maximum relative displacement and the residual deformation in the structure.

  11. Translational Contributions of the Experimental Analysis of Behavior

    Science.gov (United States)

    Critchfield, Thomas S.

    2011-01-01

    It has been argued that to increase societal impact behavioral researchers must do more to address problems of obvious practical importance. The basic science wing of behavior analysis has been described as especially detached from this goal, but is it really necessary that basic science demonstrate social relevance? If so, why hasn't this…

  12. Full scale experimental analysis of wind direction changes (EOD)

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose

    2007-01-01

    the magnitudes of a joint gust event defined by a simultaneously wind speed- and direction change in order to obtain an indication of the validity of the magnitudes specified in the IEC code. The analysis relates to pre-specified recurrence periods and is based on full-scale wind field measurements. The wind...

  13. Nonlinear Analysis of Experimental Measurements 7.6. Theoretical Chemistry

    Science.gov (United States)

    2015-01-26

    statistics of single molecule reaction trajectories and single cell microarray data (c) analysis of cytoadhesion and binding kinetics experiments; and (d...These research projects are motivated by single molecule measurements of complex biophysical processes, including photosynthetic energy transfer...enzymatic turnover reactions, and adhesion of cells. Single molecule experiments probe stochastic fluctuations on a broad range of temporal and spatial

  14. ProXL (Protein Cross-Linking Database): A Platform for Analysis, Visualization, and Sharing of Protein Cross-Linking Mass Spectrometry Data.

    Science.gov (United States)

    Riffle, Michael; Jaschob, Daniel; Zelter, Alex; Davis, Trisha N

    2016-08-05

    ProXL is a Web application and accompanying database designed for sharing, visualizing, and analyzing bottom-up protein cross-linking mass spectrometry data with an emphasis on structural analysis and quality control. ProXL is designed to be independent of any particular software pipeline. The import process is simplified by the use of the ProXL XML data format, which shields developers of data importers from the relative complexity of the relational database schema. The database and Web interfaces function equally well for any software pipeline and allow data from disparate pipelines to be merged and contrasted. ProXL includes robust public and private data sharing capabilities, including a project-based interface designed to ensure security and facilitate collaboration among multiple researchers. ProXL provides multiple interactive and highly dynamic data visualizations that facilitate structural-based analysis of the observed cross-links as well as quality control. ProXL is open-source, well-documented, and freely available at https://github.com/yeastrc/proxl-web-app .

  15. Analysis of the factors linked to a diagnosis of attention deficit hyperactivity disorder in children.

    Science.gov (United States)

    Rivas-Juesas, C; de Dios, J G; Benac-Prefaci, M; Colomer-Revuelta, J

    2017-09-01

    Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder originating from multiple factors. The aim of this study is to determine the percentage of patients with ADHD out of all patients referred to our clinic for assessment, and to explore the epidemiological and clinical factors linked to this diagnosis. retrospective analytical study of a sample of patients under 15 years old sent to the paediatric neurology clinic for suspected ADHD. DSM-IV criteria were used for diagnosis. We completed a binary logistic regression analysis to determine which risk factors were associated with the diagnosis. Of the 280 selected patients, 224 were male (male/female ratio 4:1); mean age (SD) was 8.4 (3.08) years. Almost half (49%) of the patients were referred by their schools and 64.9% were born in the second half of the year, but this tendency was more marked in girls than in boys. Assessment according to DSM-IV criteria resulted in diagnosis of 139 subjects (49.7%). The risk factors linked to diagnosis were male sex, parents with ADHD, associated sleep disorders, tics, and absence of neurodevelopmental delay. Only half of the children referred for suspected ADHD were diagnosed with that condition, and most were among the youngest in their classes, which suggests that suspected ADHD is overestimated. An exhaustive clinical interview investigating the family's psychological disorders and the patient's sleep disorders and tics is needed to improve the diagnostic process. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Corneal Collagen Cross-Linking for Infectious Keratitis: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Papaioannou, Lamprini; Miligkos, Michael; Papathanassiou, Miltiadis

    2016-01-01

    To assess the efficacy of corneal collagen cross-linking (CXL) in the management of infectious keratitis. Comprehensive literature search was performed in MEDLINE/PubMed and Cochrane Central Register of Controlled Trials using combinations of the following search terms: "corneal collagen cross linking" or "photoactivated riboflavin" or "UVA light and riboflavin" and "infectious keratitis" or "corneal ulcer." Last search was on March 19, 2015. Extracted data from individual studies were summarized and summary proportions of eyes healed and complications for different subgroups were estimated. Twenty-five studies were included (2 randomized controlled trials, 13 case series, and 10 case reports) with a total of 210 eyes of 209 patients, of which 175 eyes underwent CXL. Causative microorganisms were bacteria, fungi, acanthamoeba, and Herpes simplex virus in 96, 32, 11, and 2 cases, respectively. Coinfections were present in 13 and cause was inconclusive in 21 cases. Sixteen of 175 eyes received no additional antibiotics, whereas 159 underwent CXL as an adjunct to antimicrobial treatment. Proportion of eyes healed with CXL was 87.2% (95% confidence interval (CI), 81.9%, 91.8%). For bacterial keratitis, the proportion of eyes healed was 85.7% (95% CI, 78.5%, 91.7%), whereas 10/11 and 25/32 eyes with acanthamoeba and fungal keratitis, respectively, were healed (available data not sufficient to provide a valid proportion analysis). Treatment resulted in corneal melting and tectonic keratoplasty in both Herpes simplex virus cases. CXL seems promising in the management of infectious keratitis, excluding viral infections. However, more randomized controlled trials are required to assess its efficacy.

  17. Experimental Analysis on Shrinkage and Swelling in Ordinary Concrete

    Directory of Open Access Journals (Sweden)

    Barbara Kucharczyková

    2017-01-01

    Full Text Available The paper deals with the experimental determination of shrinkage development during concrete ageing. Three concrete mixtures were made. They differed in the amount of cement in the fresh mixture, 300, 350, and 400 kg/m3. In order to determine the influence of plasticiser on the progress of volume changes, another three concrete mixtures were prepared with plasticiser in the amount of 0.25% by cement mass. Measurements were performed with the goal of observing the influence of cement and plasticiser content on the overall development of volume changes in the concrete. Changes in length and mass losses of the concrete during ageing were measured simultaneously. The continuous measurement of concrete mass losses caused by drying of the specimen’s surface proved useful during the interpretation of results obtained from the concrete shrinkage measurement. During the first 24 hours of ageing, all the concrete mixtures exhibited swelling. Its magnitude and progress were influenced by cement, water, and plasticiser content. However, a loss of mass caused by water evaporation from the surface of the specimens was also recorded in this stage. The measured progress of shrinkage corresponded well to the progress of mass loss.

  18. Progress in the analysis of experimental chaos through periodic orbits

    Energy Technology Data Exchange (ETDEWEB)

    Badii, R. (Paul Scherrer Institute, CH-5232 Villigen (Switzerland)); Brun, E. (Physics Institute, University of Zuerich, CH-8057 Zuerich (Switzerland)); Finardi, M. (Paul Scherrer Institute, CH-5232 Villigen (Switzerland)); Flepp, L.; Holzner, R.; Parisi, J.; Reyl, C.; Simonet, J. (Physics Institute, University of Zuerich, CH-8057 Zuerich (Switzerland))

    1994-10-01

    The understanding of chaotic systems can be considerably improved with the knowledge of their periodic-orbit structure. The identification of the low-order unstable periodic orbits embedded in a strange attractor induces a hierarchical organization of the dynamics which is invariant under smooth coordinate changes. The applicability of this technique is by no means limited to analytical or numerical calculations, but has been recently extended to experimental time series. As a specific example, the authors review some of the major results obtained on a nuclear-magnetic-resonance laser which have led to an extension of the conventional (Bloch-Kirchhoff) equations of motion, to the construction of approximate generating partitions, and to an efficient control of the chaotic system around various unstable periodic orbits. The determination of the symbolic dynamics, with the precision achieved by recording all unstable cycles up to order 9, improves the topological and metric characterization of a heteroclinic crisis. The periodic-orbit approach permits detailed study of chaotic motion, thereby leading to an improved classification scheme which subsumes the older ones, based on estimates of scalar quantities such as fractal dimensions and metric entropies.

  19. Impact of environmental traders on water markets: An experimental analysis

    Science.gov (United States)

    Tisdell, John G.

    2010-03-01

    This paper reports the results of a series of economic experiments in which an environmental agency with a stochastic demand function enters an existing water market to buy or sell water for instream use. Previous experimental studies have examined the use of tenders to reduce water extractions and social suasion to maintain aggregate flow levels and compared imposing minimum flow restrictions with subsidizing downstream water use and the allocation of tradeable minimum flow rights. The important contribution of this paper is that it explores the consequence of having an environmental agency enter an existing water market. In this paper we explore the consequences of (1) formally allocating tradeable water rights to the environmental agency, (2) allocating funding to purchase water as required, and (3) having the trading actions of the environmental agency a matter of public record. The research, while contextualized to water markets in this paper, addresses an important and timely issue that could have implication beyond water markets. In pollution permit markets, for example, there is the question of what the impact on the market would be if a government agency were to begin buying back permits, particularly if this represented a relatively large volume of trades and entered into such purchases on a needs basis.

  20. Experimental stability analysis of different water-based nanofluids

    Directory of Open Access Journals (Sweden)

    Barison Simona

    2011-01-01

    Full Text Available Abstract In the recent years, great interest has been devoted to the unique properties of nanofluids. The dispersion process and the nanoparticle suspension stability have been found to be critical points in the development of these new fluids. For this reason, an experimental study on the stability of water-based dispersions containing different nanoparticles, i.e. single wall carbon nanohorns (SWCNHs, titanium dioxide (TiO2 and copper oxide (CuO, has been developed in this study. The aim of this study is to provide stable nanofluids for selecting suitable fluids with enhanced thermal characteristics. Different dispersion techniques were considered in this study, including sonication, ball milling and high-pressure homogenization. Both the dispersion process and the use of some dispersants were investigated as a function of the nanoparticle concentration. The high-pressure homogenization was found to be the best method, and the addition of n-dodecyl sulphate and polyethylene glycol as dispersants, respectively in SWCNHs-water and TiO2-water nanofluids, improved the nanofluid stability.

  1. Experimental analysis of drilling process in cortical bone.

    Science.gov (United States)

    Wang, Wendong; Shi, Yikai; Yang, Ning; Yuan, Xiaoqing

    2014-02-01

    Bone drilling is an essential part in orthopaedics, traumatology and bone biopsy. Prediction and control of drilling forces and torque are critical to the success of operations involving bone drilling. This paper studied the drilling force, torque and drilling process with automatic and manual drill penetrating into bovine cortical bone. The tests were performed on a drilling system which is used to drill and measure forces and torque during drilling. The effects of drilling speed, feed rate and drill bit diameter on force and torque were discussed separately. The experimental results were proven to be in accordance with the mathematic expressions introduced in this paper. The automatic drilling saved drilling time by 30-60% in the tested range and created less vibration, compared to manual drilling. The deviation between maximum and average force of the automatic drilling was 5N but 25N for manual drilling. To conclude, using the automatic method has significant advantages in control drilling force, torque and drilling process in bone drilling. Copyright © 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

  2. Experimental Dynamic Analysis of a Breathing Cracked Rotor

    Science.gov (United States)

    Guo, Chao-Zhong; Yan, Ji-Hong; Bergman, Lawrence A.

    2017-09-01

    Crack fault diagnostics plays a critical role for rotating machinery in the traditional and Industry 4.0 factory. In this paper, an experiment is set up to study the dynamic response of a rotor with a breathing crack as it passes through its 1/2, 1/3, 1/4 and 1/5 subcritical speeds. A cracked shaft is made by applying fatigue loads through a three-point bending apparatus and then placed in a rotor testbed. The vibration signals of the testbed during the coasting-up process are collected. Whirl orbit evolution at these subcritical speed zones is analyzed. The Fourier spectra obtained by FFT are used to investigate the internal frequencies corresponding to the typical orbit characteristics. The results show that the appearance of the inner loops and orientation change of whirl orbits in the experiment are agreed well with the theoretical results obtained previously. The presence of higher frequencies 2X, 3X, 4X and 5X in Fourier spectra reveals the causes of subharmonic resonances at these subcritical speed zones. The experimental investigation is more systematic and thorough than previously reported in the literature. The unique dynamic behavior of the orbits and frequency spectra are feasible features for practical crack diagnosis. This paper provides a critical technology support for the self-aware health management of rotating machinery in the Industry 4.0 factory.

  3. Recency, repeatability, and reinforcer retrenchment: an experimental analysis of resurgence.

    Science.gov (United States)

    Lieving, Gregory A; Lattal, Kennon A

    2003-09-01

    Four experiments were conducted with pigeons to assess the experimental conditions necessary for the occurrence of resurgence. The general procedure consisted of the following conditions: Condition 1--reinforcement of key pecking; Condition 2--reinforcement of treadle pressing and concurrent extinction of key pecking; and Condition 3--the resurgence condition wherein resurgence was defined as the recovery of key pecking. In Experiments 1 and 2, the resurgence condition was conventional extinction. The effect of recency on resurgence magnitude was examined in Experiment 1 by manipulating the number of sessions of Condition 2, above. Resurgence was not a function of recency with the parameters used. Repeating the three conditions revealed resurgence to be a repeatable effect in Experiment 2. In Experiment 3, a variable-time schedule was in effect for the resurgence condition. Resurgence was not produced by response-independent food delivery. In Experiment 4, the resurgence condition was a variable-interval schedule for treadle pressing that arranged a lower reinforcement rate than in Condition 2 (92% reduction in reinforcers per minute). Resurgence was lower in magnitude relative to conventional extinction, although resurgence was obtained with 2 out of 3 pigeons. The results are discussed in terms of the variables controlling resurgence and the relations between behavioral history, resurgence, and other forms of response recovery.

  4. Histopathological analysis in experimental macular surgery with trypan blue.

    Science.gov (United States)

    Grisanti, S; Szurman, P; Tatar, O; Gelisken, F; Aisenbrey, S; Oficjalska-Mlynczak, J; Kaczmarek, R; Bartz-Schmidt, K U

    2004-09-01

    To analyse the effect of trypan blue on the retina in an experimental setting of macular surgery. Porcine eyes were used within 3 hours after death. The eyes were hemisected and the vitreous removed. Trypan blue (0.15%) was applied over the trephined posterior pole, whereas the rest of the eye cup was filled with a balanced salt solution (BSS). The dye and the BSS were removed after 1 minute and the complete eye cup irrigated and filled with fresh BSS. Both the treated and untreated retinas were illuminated with a standard surgical light pipe and source at maximum power for 10 minutes. Both the trypan blue exposed retina and the non-treated surrounding retina were processed for histology. Exposure of the retina to trypan blue for 1 minute, followed by illumination caused no histologically detectable damage compared to the controls. No microarchitectural disorganisation, cellular disruption, or affection of the vitreoretinal interface was detected. These findings indicate that a 1 minute exposure of trypan blue followed by illumination does not cause an acute morphologically detectable toxic effect on the porcine retina.

  5. Experimental analysis of dense multipath components in an industrial environment

    OpenAIRE

    Tanghe, Emmeric; Gaillot, Davy P.; Liénard, Martine; Martens, Luc; Joseph, Wout

    2014-01-01

    This work presents an analysis of dense multipath components (DMC) in an industrial workshop. Radio channel sounding was performed with a vector network analyzer and virtual antenna arrays. The specular and dense multipath components were estimated with the RiMAX algorithm. The DMC covariance structure of the RiMAX data model was validated. Two DMC parameters were studied: the distribution of radio channel power between specular and dense multipath, and the DMC reverberation time. The DMC pow...

  6. Experimental methods and data analysis for fluctuation microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Voyles, P. M.; Treacy, M. M. J.; Gibson, J. M.; Jin, H.-C.; Abelson, J. R.

    2000-02-16

    The authors have developed a new electron microscopy technique called fluctuation microscopy which is sensitive to medium-range order in disordered materials. The technique relies on quantitative statistical analysis of low-resolution dark-field electron micrographs. Extracting useful information from such micrographs involves correcting for the effects of the imaging system, incoherent image contrast caused by large scale structure in the sample, and the effects of the foil thickness.

  7. Is Pain Perception Altered in People With Depression? A Systematic Review and Meta-Analysis of Experimental Pain Research.

    Science.gov (United States)

    Thompson, Trevor; Correll, Christoph U; Gallop, Katy; Vancampfort, Davy; Stubbs, Brendon

    2016-12-01

    Although clinical studies suggest depressed patients may be more vulnerable to pain, experimental research is equivocal. This meta-analysis aimed to clarify whether depression is associated with altered pain perception in response to noxious stimulation and to identify factors that might influence this association. A search of major electronic databases was conducted to identify experimental studies investigating pain response in depressed participants versus healthy control participants using established pain outcome measures. Random effects meta-analysis of standardized mean differences was conducted on data from 32 studies (N = 1,317). For high-intensity noxious stimulation, overall pain tolerance was similar across depressed and control groups (Hedges g = .09, P = .71, studies = 10). For low-intensity stimulation, a small, but statistically significant higher mean sensory threshold (g = .35, P = .01, studies = 9) and pain threshold (g = .32, P = .02, studies = 25) was observed in depressed participants, suggesting diminished pain. However, considerable heterogeneity in the direction and magnitude of effects was observed, indicating a likely condition-specific effect of depression on pain. Subgroup analysis found that pain threshold/tolerance was increased in depression for exteroceptive (cutaneous) stimulation but decreased for interoceptive (ischemic) stimulation, but that substantial heterogeneity remained. Overall, results provide some support for altered pain processing in depression, but suggest this link is dependent upon modality and additional, unidentified factors. This meta-analysis of experimental studies suggests potential effects of depression on pain perception are variable and likely to depend upon multiple factors. The contrasting pattern for ischemic versus other noxious stimuli suggests that stimulus modality is a key factor, which could help explain discrepancies across clinical and experimental findings. Copyright

  8. Experimental Analysis of Bisbenzocyclobutene Bonded Capacitive Micromachined Ultrasonic Transducers.

    Science.gov (United States)

    Manwar, Rayyan; Chowdhury, Sazzadur

    2016-06-24

    Experimental measurement results of a 1.75 mm × 1.75 mm footprint area Capacitive Micromachined Ultrasonic Transducer (CMUT) planar array fabricated using a bisbenzocyclobutene (BCB)-based adhesive wafer bonding technique has been presented. The array consists of 40 × 40 square diaphragm CMUT cells with a cavity thickness of 900 nm and supported by 10 µm wide dielectric spacers patterned on a thin layer of BCB. A 150 µm wide one µm thick gold strip has been used as the contact pad for gold wire bonding. The measured resonant frequency of 19.3 MHz using a Polytec™ laser Doppler vibrometer (Polytec™ MSA-500) is in excellent agreement with the 3-D FEA simulation result using IntelliSuite™. An Agilent ENA5061B vector network analyzer (VNA) has been used for impedance measurement and the resonance and anti-resonance values from the imaginary impedance curve were used to determine the electromechanical coupling co-efficient. The measured coupling coefficient of 0.294 at 20 V DC bias exhibits 40% higher transduction efficiency as compared to a measured value published elsewhere for a silicon nitride based CMUT. A white light interferometry method was used to measure the diaphragm deflection profiles at different DC bias. The diaphragm center velocity was measured for different sub-resonant frequencies using a Polytec™ laser Doppler vibrometer that confirms vibration of the diaphragm at different excitation frequencies and bias voltages. Transmit and receive operations of CMUT cells were characterized using a pitch-catch method and a -6 dB fractional bandwidth of 23% was extracted from the received signal in frequency domain. From the measurement, it appears that BCB-based CMUTs offer superior transduction efficiency as compared to silicon nitride or silicon dioxide insulator-based CMUTs, and provide a very uniform deflection profile thus making them a suitable candidate to fabricate highly energy efficient CMUTs.

  9. Seizure states identification in experimental epilepsy using gabor atom analysis.

    Science.gov (United States)

    Sotelo, Arturo; Guijarro, Enrique D; Trujillo, Leonardo

    2015-02-15

    Epileptic seizures evolve through several states, and in the process the brain signals may change dramatically. Signals from different states share similar features, making it difficult to distinguish them from a time series; the goal of this work is to build a classifier capable of identifying seizure states based on time-frequency features taken from short signal segments. There are different amounts of frequency components within each Time-Frequency window for each seizure state, referred to as the Gabor atom density. Taking short signal segments from the different states and decomposing them into their atoms, the present paper suggests that is possible to identify each seizure state based on the Gabor atom density. The brain signals used in this work were taken form a database of intracranial recorded seizures from the Kindling model. The findings suggest that short signal segments have enough information to be used to derive a classifier able to identify the seizure states with reasonable confidence, particularly when used with seizures from the same subject. Achieving average sensitivity values between 0.82 and 0.97, and area under the curve values between 0.5 and 0.9. The experimental results suggest that seizure states can be revealed by the Gabor atom density; and combining this feature with the epoch's energy produces an improved classifier. These results are comparable with the recently published on state identification. In addition, considering that the order of seizure states is unlikely to change, these results are promising for automatic seizure state classification. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. 40 CFR 158.2171 - Experimental use permit microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Experimental use permit microbial pesticides product analysis data requirements table. 158.2171 Section 158.2171 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2171 Experimental use...

  11. Critical Discourse Analysis and Critical Thinking: An Experimental Study in an EFL Context

    Science.gov (United States)

    Hashemi, Mohammad Reza; Ghanizadeh, Afsaneh

    2012-01-01

    The present study investigated the impact of critical discourse analysis (CDA) on TEFL students' critical thinking (CT) ability in "Reading Journalistic Texts" classes. In so doing, the study utilized an experimental design with 24 participants in the control group and 29 participants in the experimental group. The results of a pretest indicated…

  12. Experimental analysis of Taylor vortex solid-liquid separation

    OpenAIRE

    河合, 秀樹; 岸川, 真吾; 木倉, 宏成; 有冨, 正憲; 高橋, 洋志

    2004-01-01

    It is known that rotating membrane filtration using a Taylor-Couette vortex flow (TCVF) system has an effect which reduces build-up of a cake layer on a surface of membrane filter. Although it is expected that the effect leads, for example to development of a new hemodialysis filter, fluid dynamic analysis is seldom performed. Here, TCVF is visualized by laser sheet device to study the fundamental vortex structure and then, by replacing the rigid inner cylinder with the filter, the particle-l...

  13. Segregation analysis in X-linked ichthyosis: paternal transmission of the affected X-chromosome.

    Science.gov (United States)

    Toral-Lopez, J; González-Huerta, L M; Cuevas-Covarrubias, S A

    2008-04-01

    Steroid sulphatase (STS) deficiency has been described in a diversity of ethnic populations. The phenotype of STS deficiency, X-linked ichthyosis (XLI), is a genodermatosis characterized by dark scaly skin. About 90% of patients with XLI have complete deletion of the entire STS gene and flanking sequences. The variable number tandem repeats, on either side of the STS gene, appear to play an important role in these interstitial deletions due to nonallelic homologous recombination (NAHR). It is difficult to establish if this NAHR occurs between two chromosomes, between sister chromatids or between the same chromatid. To identify the parental origin of the affected X-chromosome in seven unrelated sporadic cases of XLI. Amplification of the regions from DXS89 to DXS1134 (telomeric-centromeric) including the 5' and 3' ends of the STS gene was performed through polymerase chain reaction. GeneScan analysis was performed using the DXS987, DXS8051 and DXS1060 markers located on the short arm of the X-chromosome. Fluorescence in situ hybridization analysis was performed with a digoxigenin-labelled cDNA STS probe. STS gene deletion in patients with XLI involved the sequences DXS1139 and DXF22S1. In five families segregation analysis showed paternal transmission of the affected X-chromosome in the XLI carrier. It was not possible to determine the parental origin of the affected X-chromosome in two families. These data strongly suggest that STS gene deletion occurred in the male meiosis probably due to an intrachromosomal event, recombination between S232 sequences on the same DNA molecule, or during the process of DNA replication.

  14. Linking dynamic phenotyping with metabolite analysis to study natural variation in drought responses of Brachypodium distachyon

    Directory of Open Access Journals (Sweden)

    Lorraine H.C. Fisher

    2016-11-01

    Full Text Available Drought is an important environmental stress limiting the productivity of major crops worldwide. Understanding drought tolerance and possible mechanisms for improving drought resistance is therefore a prerequisite to develop drought-tolerant crops that produce significant yields with reduced amounts of water. Brachypodium distachyon (Brachypodium is a key model species for cereals, forage grasses and energy grasses. In this study, initial screening of a Brachypodium germplasm collection consisting of 138 different ecotypes exposed to progressive drought, highlighted the natural variation in morphology, biomass accumulation and responses to drought stress. A core set of ten ecotypes, classified as being either tolerant, susceptible or intermediate, in response to drought stress, were exposed to mild or severe (respectively 15% and 0% soil water content drought stress and phenomic parameters linked to growth and colour changes were assessed. When exposed to severe drought stress, phenotypic data and metabolite profiling combined with multivariate analysis revealed a remarkable consistency in separating the selected ecotypes into their different pre-defined drought tolerance groups. Increases in several metabolites, including for the phytohormones jasmonic acid and salicylic acid, and TCA-cycle intermediates, were positively correlated with biomass yield and with reduced yellow pixel counts; suggestive of delayed senescence, both key target traits for crop improvement to drought stress. While metabolite analysis also separated ecotypes into the distinct tolerance groupings after exposure to mild drought stress, similar analysis of the phenotypic data failed to do so, confirming the value of metabolomics to investigate early responses to drought stress. The results highlight the potential of combining the analyses of phenotypic and metabolic responses to identify key mechanisms and markers associated with drought tolerance in both the Brachypodium

  15. Experimental and Numerical analysis of Metallic Bellow for Acoustic Performance

    Science.gov (United States)

    Panchwadkar, Amit A.; Awasare, Pradeep J., Dr.; Ingle, Ravidra B., Dr.

    2017-08-01

    Noise will concern about the work environment of industry. Machinery environment has overall noise which interrupts communication between the workers. This problem of miscommunication and health hazard will make sense to go for noise attenuation. Modification in machine setup may affect the performance of it. Instead of that, Helmholtz resonator principle will be a better option for noise reduction along the transmission path. Resonator has design variables which gives resonating frequency will help us to confirm the frequency range. This paper deals with metallic bellow which behaves like inertial mass under incident sound wave. Sound wave energy is affected by hard boundary condition of resonator and bellow. Metallic bellow is used in combination with resonator to find out Transmission loss (TL). Microphone attachment with FFT analyzer will give the frequency range for numerical analysis. Numerical analysis of bellow and resonator is carried out to summarize the acoustic behavior of bellow. Bellow can be numerically analyzed to check noise attenuation for centrifugal blower. An impedance tube measurement technique is performed to validate the numerical results for assembly. Dimensional and shape modification can be done to get the acoustic performance of bellow.

  16. Optimization of Formaldehyde Cross-Linking for Protein Interaction Analysis of Non-Tagged Integrin β1

    Science.gov (United States)

    Klockenbusch, Cordula; Kast, Juergen

    2010-01-01

    Formaldehyde cross-linking of protein complexes combined with immunoprecipitation and mass spectrometry analysis is a promising technique for analysing protein-protein interactions, including those of transient nature. Here we used integrin β1 as a model to describe the application of formaldehyde cross-linking in detail, particularly focusing on the optimal parameters for cross-linking, the detection of formaldehyde cross-linked complexes, the utility of antibodies, and the identification of binding partners. Integrin β1 was found in a high molecular weight complex after formaldehyde cross-linking. Eight different anti-integrin β1 antibodies were used for pull-down experiments and no loss in precipitation efficiency after cross-linking was observed. However, two of the antibodies could not precipitate the complex, probably due to hidden epitopes. Formaldehyde cross-linked complexes, precipitated from Jurkat cells or human platelets and analyzed by mass spectrometry, were found to be composed of integrin β1, α4 and α6 or β1, α6, α2, and α5, respectively. PMID:20634879

  17. Numerical and experimental microscale analysis of the incremental forming process

    Science.gov (United States)

    Szyndler, Joanna; Delannay, Laurent; Muszka, Krzysztof; Madej, Lukasz

    2017-10-01

    Development of the 2D concurrent multiscale numerical model of novel incremental forming (IF) process is the main aim of the paper. The IF process is used to obtain light and durable integral parts, especially useful in aerospace or automotive industries. Particular attention in the present work is put on numerical investigation of material behavior at both, macro and micro scale levels. A Finite Element Method (FEM) supported by Digital Material Representation (DMR) concept is used during the investigation. Also, the Crystal Plasticity (CP) theory is applied to describe material flow at the grain level. Examples of obtained results both from the macro and micro scales are presented in the form of strain distributions, grain shapes and pole figures at different process stages. Moreover, Electron Backscatter Diffraction (EBSD) analysis is used to obtain detailed information regarding material morphology changes during the incremental forming for the comparison purposes.

  18. The Analysis of Experimental Results of Reinforcement Learning Systems

    Directory of Open Access Journals (Sweden)

    Jaroslav E. Poliscuk

    2002-07-01

    Full Text Available In this article a reinforcement learning method is analyzed, in which a subject of learning is defined. The essence of this method is the selection of activities by a try and fail process and awarding deferred rewards. If an environment is characterized by the Markov property, then step-by-step dynamics will enable forecasting of subsequent conditions and awarding subsequent rewards on the basis of the present known conditions and actions, relatively to the Markov decision making process. The relationship between the present conditions and values and the potential future conditions are defined by the Bellman equation. Also, the article discussed a method of temporal difference learning, mechanism of eligibility traces, as well as theirs algorithms TD(0 and TD(Lambda. Theoretical analysis were supplemented by the practical studies, with reference to implementation of the Sarsa(Lambda algorithm, with replacing eligibility traces and the Epsilon greedy policy.

  19. Wireless sensor networks concepts, applications, experimentation and analysis

    CERN Document Server

    Fahmy, Hossam Mahmoud Ahmad

    2016-01-01

    This book focuses on the principles of wireless sensor networks (WSNs), their applications, and their analysis tools, with meticulous attention paid to definitions and terminology. This book presents the adopted technologies and their manufacturers in detail, making WSNs tangible for the reader. In introductory computer networking books, chapter sequencing follows the bottom-up or top-down architecture of the 7-layer protocol. This book addresses subsequent steps in this process, both horizontally and vertically, thus fostering a clearer and deeper understanding through chapters that elaborate on WSN concepts and issues. With such depth, this book is intended for a wide audience; it is meant to be a helper and motivator for senior undergraduates, postgraduates, researchers, and practitioners. It lays out important concepts and WSN-relate applications; uses appropriate literature to back research and practical issues; and focuses on new trends. Senior undergraduate students can use it to familiarize themselves...

  20. Experimental and numerical analysis of Al6063 duralumin using Taylor impact test

    Directory of Open Access Journals (Sweden)

    Grązka M.

    2012-08-01

    Full Text Available The paper presents results of experimental and numerical analysis of dynamic behaviour Al6063 duralumin. Dynamical experiments were made using Taylor impact test. Experimental results at next step of study were used in numerical analyses of dynamic yield stress of tested material and model parameters of the Johnson–Cook constitutive equation. The main aim of this analysis is to find out dynamical properties of Al6063 duralumin tested in Taylor impact test.

  1. Experimental and numerical analysis of thermal striping in automotive brake discs

    OpenAIRE

    Augustins, L; Hild, Francois; Billardon, R; Boudevin, S

    2017-01-01

    International audience; In the present study, thermal striping development on friction bands of brake discs is investigated through an experimental and numerical analysis. A test consisting of a series of several hundred severe brakings was carried out on a specific bench at PSA Peugeot Citroën. The experimental observations of the crack network evolution and a numerical analysis of a brake disc with a single crack helped to propose a macroscopic criterion capable of predicting the criticalit...

  2. Pricing Strategies under Emissions Trading - an experimental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wraake, Markus; Myers, Erica; Mandell, Svante; Holt, Charles; Burtraw, Dallas

    2008-10-15

    An important feature in the design of an emissions trading program is how emission allowances are initially distributed into the market. The choice between an auction and free allocation should, according to economic theory, not have any influence on the firms' production choices nor on consumer prices. However, many observers are still incredulous that firms should be expected to raise product prices to include the value of emissions allowances they receive for free. Throughout much of Europe and the U.S., energy markets have been deregulated or are in the process of moving toward market liberalization. If market behavior does not conform to predictions of behavior in a competitive market, this may say a great deal about the nature of market liberalization in energy markets as well as about the behavior of environmental markets. If firms are able to voluntarily moderate commodity prices to be below competitive levels, it suggests an ability of these entities to exercise market power or collude - even if this is motivated by a desire to hold back and not pass through the value of emissions allowances in product prices. This paper reports on the use of experimental methods to investigate behavior with respect to how prices will be determined under a cap-and-trade program. We find participants in the experiments employ various approaches. Some participants initially recognize the opportunity cost of emission allowances and included them in their economic choices regardless of how the allowances have been obtained, and other subjects initially do not. However, given a simple economic setting in which payoffs depend on this behavior, we find that subjects learn to consider the value of allowances and overall behavior moves toward that predicted by economic theory. The observations from the experiments may help to understand the ongoing public debate over the interaction of the EU ETS and energy markets. Emission allowance markets are a new phenomenon to many

  3. Reducing experimental variability in variance-based sensitivity analysis of biochemical reaction systems.

    Science.gov (United States)

    Zhang, Hong-Xuan; Goutsias, John

    2011-03-21

    Sensitivity analysis is a valuable task for assessing the effects of biological variability on cellular behavior. Available techniques require knowledge of nominal parameter values, which cannot be determined accurately due to experimental uncertainty typical to problems of systems biology. As a consequence, the practical use of existing sensitivity analysis techniques may be seriously hampered by the effects of unpredictable experimental variability. To address this problem, we propose here a probabilistic approach to sensitivity analysis of biochemical reaction systems that explicitly models experimental variability and effectively reduces the impact of this type of uncertainty on the results. The proposed approach employs a recently introduced variance-based method to sensitivity analysis of biochemical reaction systems [Zhang et al., J. Chem. Phys. 134, 094101 (2009)] and leads to a technique that can be effectively used to accommodate appreciable levels of experimental variability. We discuss three numerical techniques for evaluating the sensitivity indices associated with the new method, which include Monte Carlo estimation, derivative approximation, and dimensionality reduction based on orthonormal Hermite approximation. By employing a computational model of the epidermal growth factor receptor signaling pathway, we demonstrate that the proposed technique can greatly reduce the effect of experimental variability on variance-based sensitivity analysis results. We expect that, in cases of appreciable experimental variability, the new method can lead to substantial improvements over existing sensitivity analysis techniques.

  4. Experimental performance analysis for mini-parabolic solar reflecting collectors

    Energy Technology Data Exchange (ETDEWEB)

    Barakos, G.; Kaplanis, S.; Spyrogiannoulas, A. [Technological Educational Inst. of Patras, Patra (Greece)

    2007-07-01

    This paper presented a detailed analysis of the thermal behaviour of a mini-parabolic solar reflecting collector installed on the roof of a building. A data logging system was used to monitor fluid inlet and outlet temperatures in the absorber; total solar radiation incident on the aperture surface; ambient temperatures; and fluid flow measurements. The aim of the study was to increase the reliability of the collector, maximize output, and optimize the geometrical and physical characteristics of the collector's components. Experiments were conducted over a 4-day period in October and November 2006 at a location in Greece. Data obtained during the experiments showed that as the mass flow rate increased, the outlet and inlet temperatures decreased. The system's efficiency increased as the mass flow rate increased. Losses were decreased when temperatures in the tube absorber remained low. The results of several subsequent experiments confirmed that higher mass flow rates increase the efficiency of the collectors.15 refs., 10 figs.

  5. Genetic mapping of X-linked ocular albinism: Linkage analysis in a large Newfoundland kindred

    Energy Technology Data Exchange (ETDEWEB)

    Charles, S.J.; Moore, A.T.; Barton, D.E.; Yates, J.R.W. (Addenbrooke' s Hospital, Cambridge (United Kingdom)); Green, J.S. (Memorial Univ. of Newfoundland, St. John' s (Canada))

    1993-04-01

    Genetic linkage studies in a large Newfoundland family affected by X-linked ocular albinism (OA1) showed linkage to markers from Xp22.3. One recombinant mapped the disease proximal to DXS143 (dic56) and two recombinants mapped the disease distal to DXS85 (782). Combining the data with that from 16 British families previously published confirmed close linkage between OA1 and DXS143 (dic56; Z[sub max] = 21.96 at [theta] = 0.01, confidence interval (CI) 0.0005--0.05) and linkage to DXS85 (782; Z[sub max] = 17.60 at [theta] = 0.07, CI = 0.03--0.13) and DXS237 (GMGX9; Z[sub max] = 15.20 at [theta] = 0.08, CI = 0.03--0.15). Multipoint analysis (LINKMAP) gave the most likely order as Xpter-XG-DXS237-DXS143-OA1-DXS85, with odds of 48:1 over the order Xpter-XG-DXS237-OA1-DXS143-DXS85, and odds exceeding 10[sup 10]:1 over other locations for the disease locus. 11 refs., 1 fig., 1 tab.

  6. A multi-platform linking code for fuel burnup and radiotoxicity analysis

    Science.gov (United States)

    Cunha, R.; Pereira, C.; Veloso, M. A. F.; Cardoso, F.; Costa, A. L.

    2014-02-01

    A linking code between ORIGEN2.1 and MCNP has been developed at the Departamento de Engenharia Nuclear/UFMG to calculate coupled neutronic/isotopic results for nuclear systems and to produce a large number of criticality, burnup and radiotoxicity results. In its previous version, it evaluated the isotopic composition evolution in a Heat Pipe Power System model as well as the radiotoxicity and radioactivity during lifetime cycles. In the new version, the code presents features such as multi-platform execution and automatic results analysis. Improvements made in the code allow it to perform simulations in a simpler and faster way without compromising accuracy. Initially, the code generates a new input for MCNP based on the decisions of the user. After that, MCNP is run and data, such as recoverable energy per prompt fission neutron, reaction rates and keff, are automatically extracted from the output and used to calculate neutron flux and cross sections. These data are then used to construct new ORIGEN inputs, one for each cell in the core. Each new input is run on ORIGEN and generates outputs that represent the complete isotopic composition of the core on that time step. The results show good agreement between GB (Coupled Neutronic/Isotopic code) and Monteburns (Automated, Multi-Step Monte Carlo Burnup Code System), developed by the Los Alamos National Laboratory.

  7. Cost-Benefit Analysis of High-Speed Rail Link between Hong Kong and Mainland China

    Directory of Open Access Journals (Sweden)

    R. Tao

    2011-07-01

    Full Text Available The Legislative Council in Hong Kong has approved a funding of USD$8.60 billion to build the high-speed rail (HSR line linking mainland China. HSR is a break-through technology that allows trains running at a speed over 250 km per hour. The most controversial part of the HSR investment is whether its cost could be compensated by the social benefits. In this study, a cost-benefit analysis of the Hong Kong to mainland HSR (HKM-HSR line is carried out. First, all the direct and indirect costs, and social benefits are defined; then, monetary equivalents are assigned to these elements; third, all the future values are discounted into present values and aggregated. The results show that the project has a positive net present value (NPV up to USD$2,068.49 million, which proves that the investment is worth. In addition, other transport alternatives, i.e. the existing roadway and conventional railway, are examined and compared with HKM-HSR, which unveils that HSR has the largest positive NPV among these three passenger transportation modes because of its excellent performance in ticket revenue, travel time savings and safety improvement.

  8. How Teachers Link Ideas in Mathematics Instruction Using Speech and Gesture: A Corpus Analysis

    Science.gov (United States)

    Alibali, Martha W.; Nathan, Mitchell J.; Wolfgram, Matthew S.; Church, R. Breckinridge; Jacobs, Steven A.; Johnson Martinez, Chelsea; Knuth, Eric J.

    2014-01-01

    This research investigated how teachers express links between ideas in speech, gestures, and other modalities in middle school mathematics instruction. We videotaped 18 lessons (3 from each of 6 teachers), and within each, we identified "linking episodes"--segments of discourse in which the teacher connected mathematical ideas. For each…

  9. Linking cases of illegal shootings of the endangered California condor using stable lead isotope analysis

    Energy Technology Data Exchange (ETDEWEB)

    Finkelstein, Myra E., E-mail: myraf@ucsc.edu [Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, CA 95064 (United States); Kuspa, Zeka E. [Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, CA 95064 (United States); Welch, Alacia [National Park Service, Pinnacles National Park, 5000 Highway 146, Paicines, CA 95043 (United States); Eng, Curtis; Clark, Michael [Los Angeles Zoo and Botanical Gardens, 5333 Zoo Drive, Los Angeles, CA 90027 (United States); Burnett, Joseph [Ventana Wildlife Society, 19045 Portola Dr. Ste. F-1, Salinas, CA 93908 (United States); Smith, Donald R. [Microbiology and Environmental Toxicology Department, University of California, Santa Cruz, CA 95064 (United States)

    2014-10-15

    Lead poisoning is preventing the recovery of the critically endangered California condor (Gymnogyps californianus) and lead isotope analyses have demonstrated that ingestion of spent lead ammunition is the principal source of lead poisoning in condors. Over an 8 month period in 2009, three lead-poisoned condors were independently presented with birdshot embedded in their tissues, evidencing they had been shot. No information connecting these illegal shooting events existed and the timing of the shooting(s) was unknown. Using lead concentration and stable lead isotope analyses of feathers, blood, and recovered birdshot, we observed that: i) lead isotope ratios of embedded shot from all three birds were measurably indistinguishable from each other, suggesting a common source; ii) lead exposure histories re-constructed from feather analysis suggested that the shooting(s) occurred within the same timeframe; and iii) two of the three condors were lead poisoned from a lead source isotopically indistinguishable from the embedded birdshot, implicating ingestion of this type of birdshot as the source of poisoning. One of the condors was subsequently lead poisoned the following year from ingestion of a lead buckshot (blood lead 556 µg/dL), illustrating that ingested shot possess a substantially greater lead poisoning risk compared to embedded shot retained in tissue (blood lead ∼20 µg/dL). To our knowledge, this is the first study to use lead isotopes as a tool to retrospectively link wildlife shooting events. - Highlights: • We conducted a case-based analysis of illegal shootings of California condors. • Blood and feather Pb isotopes were used to reconstruct the illegal shooting events. • Embedded birdshot from the three condors had the same Pb isotope ratios. • Feather and blood Pb isotopes indicated that the condors were shot in a common event. • Ingested shot causes substantially greater lead exposure compared to embedded shot.

  10. Sound transmission analysis of MR fluid based-circular sandwich panels: Experimental and finite element analysis

    Science.gov (United States)

    Hemmatian, Masoud; Sedaghati, Ramin

    2017-11-01

    Magnetorheological Fluids (MR) have been recently utilized in sandwich panels to provide variable stiffness and damping to effectively control vibrations. In this study, the sound transmission behavior of MR based-sandwich panels is investigated through development of an efficient finite element model. A clamped circular sandwich panel with elastic face sheets and MR Fluid as the core layer has been considered. A finite element model utilizing circular and annular elements has been developed to derive the governing equations of motion in the finite element form. The transverse velocity is then calculated and utilized to obtain the sound radiated from the panel and subsequently the sound transmission loss. In order to validate the simulated results, a test setup including two anechoic spaces and an electro-magnet has been designed and fabricated. The magnetic flux density generated inside the electromagnet is simulated using magneto-static finite element analysis and validated with the measured magnetic flux density using Gaussmeter. The results from magneto-static analysis is used to derive an approximate polynomial function to evaluate the magnetic flux density as a function of the plate's radius and applied current. The STL and first axisymmetric natural frequency of the MR sandwich panels with aluminum face sheets are simulated and compared with those obtained experimentally. Finally, a parametric study on the effect of applied magnetic field, the thickness of the core layer and the thickness of face sheets on the STL and natural frequency of the adaptive sandwich panel are presented.

  11. Download - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...t_db_link_en.zip (36.3 KB) - 6 Genome analysis methods pgdbj_dna_marker_linkage_map_genome_analysis_methods_... of This Database Site Policy | Contact Us Download - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  12. Establishing a Link Between Prescription Drug Abuse and Illicit Online Pharmacies: Analysis of Twitter Data.

    Science.gov (United States)

    Katsuki, Takeo; Mackey, Tim Ken; Cuomo, Raphael

    2015-12-16

    Youth and adolescent non-medical use of prescription medications (NUPM) has become a national epidemic. However, little is known about the association between promotion of NUPM behavior and access via the popular social media microblogging site, Twitter, which is currently used by a third of all teens. In order to better assess NUPM behavior online, this study conducts surveillance and analysis of Twitter data to characterize the frequency of NUPM-related tweets and also identifies illegal access to drugs of abuse via online pharmacies. Tweets were collected over a 2-week period from April 1-14, 2015, by applying NUPM keyword filters for both generic/chemical and street names associated with drugs of abuse using the Twitter public streaming application programming interface. Tweets were then analyzed for relevance to NUPM and whether they promoted illegal online access to prescription drugs using a protocol of content coding and supervised machine learning. A total of 2,417,662 tweets were collected and analyzed for this study. Tweets filtered for generic drugs names comprised 232,108 tweets, including 22,174 unique associated uniform resource locators (URLs), and 2,185,554 tweets (376,304 unique URLs) filtered for street names. Applying an iterative process of manual content coding and supervised machine learning, 81.72% of the generic and 12.28% of the street NUPM datasets were predicted as having content relevant to NUPM respectively. By examining hyperlinks associated with NUPM relevant content for the generic Twitter dataset, we discovered that 75.72% of the tweets with URLs included a hyperlink to an online marketing affiliate that directly linked to an illicit online pharmacy advertising the sale of Valium without a prescription. This study examined the association between Twitter content, NUPM behavior promotion, and online access to drugs using a broad set of prescription drug keywords. Initial results are concerning, as our study found over 45,000 tweets

  13. DMFC performance and methanol cross-over: Experimental analysis and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, A.; Marchesi, R. [Dipartimento di Energia, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2008-10-15

    A combined experimental and modelling approach is proposed to analyze methanol cross-over and its effect on DMFC performance. The experimental analysis is performed in order to allow an accurate investigation of methanol cross-over influence on DMFC performance, hence measurements were characterized in terms of uncertainty and reproducibility. The findings suggest that methanol cross-over is mainly determined by diffusion transport and affects cell performance partly via methanol electro-oxidation at the cathode. The modelling analysis is carried out to further investigate methanol cross-over phenomenon. A simple model evaluates the effectiveness of two proposed interpretations regarding methanol cross-over and its effects. The model is validated using the experimental data gathered. Both the experimental analysis and the proposed and validated model allow a substantial step forward in the understanding of the main phenomena associated with methanol cross-over. The findings confirm the possibility to reduce methanol cross-over by optimizing anode feeding. (author)

  14. X-ray crystallographic analysis and DFT calculations of three 'propylene linker' dimers linked by one polystep reaction

    Science.gov (United States)

    Shi, Yan; Tan, Xue-Jie; Xing, Dian-Xiang; Sui, Qi-Cheng; Liu, Bin; Feng, Wen-Quan; Liu, Yun

    2017-06-01

    In this manuscript, we report the synthesis, NMR and single-crystal structures of three propylene linking dimers related with the hydrolytic degradation of one 5,6-dehydronorcantharimide dimer. Special attention was paid to the conformation of propylene linkers in order to understand their changes in the reaction. Statistical analysis of CSD database revealed that a-a, g-a and g-g conformations may have similar stability in most cases and various complicated unpredictable non-covalent interactions may play important role in the formation of final rotamers. In order to reproduce all stable conformations and the energy barriers separating them, full range two-dimensional fully relaxed potential-energy surfaces (PES) scans of six 'propylene linker' dimers were calculated starting from the most stable crystal structures. The PES were scanned along both bridge Csbnd C single bond torsional angles (denoted as θ1 and θ2), while all other internal coordinates were optimized at the DFT/B3LYP/3-21G* level in gas phase. Then all energy minima were re-optimized again at the DFT/B3LYP/6-311 + G(d,p) level both in gas and ethanol solutions in order to evaluate the really stable rotamers. At last, 1D or 2D relaxed PES scans were performed between local stable rotamers to get reliable energy barriers. This method represents a less time-consuming and more reliable approach to the determination of conformational stability of propanediyl bridging chains. The combination of experimental, statistical and theoretical results shows that the observed conformation is jointly determined by the energy levels of the minima, energy barriers separating them, non-covalent interactions and somewhat randomness.

  15. The potential of on-line continuous leach ICP-MS analysis for linking trace elements to mineralogy

    Science.gov (United States)

    Roskam, Gerlinde; Verheul, Marc; Moraetis, Daniel; Giannakis, George; van Gaans, Pauline

    2014-05-01

    A set of five soil samples was subjected to an on-line continuous leach inductively coupled plasma mass spectrometry experiment, with progressively reactive solvents (0.01M CaCl2, 0.1 M HNO3, 1M HNO3, 4M HNO3) Each sample was packed in a quartz tube (Ø= 1 cm, length 2 cm) and diluted 1:1 with acid washed quartz to prevent clogging. The gas that was produced during the extraction was removed by leading the effluent into a small container, from where the sample was directly pumped into the ICP-MS. 115In was used as an internal standard. Continuous leach experiments have the advantage of real time (every 2 seconds) full elemental analysis. Mineral breakdown reactions can be monitored via the major elements. The trace elements associated with the minerals are monitored simultaneously, thus eliminating the uncertainties of host mineral-trace element combinations in traditional off-line sequential extractions. The continuous leach experimental data are correlated to XRD-results for mineralogy and total elemental concentrations. The soil samples used were collected from different sites in the Koiliaris River watershed, Crete, Greece 1). The selection of the sites was based on variability in bedrock (limestone, metamorphic and alluvial sediments) and current land use (grape farming, olive trees). Soils were sampled at two depths: at the surface and just above the bedrock. No large differences in the major elements between the two depths were measured. To provide background to the on-line sequential data, also total concentrations of the major elements were analysed by XRF and the mineralogy was analysed by XRD. The fraction Roskam et al., 2014: REE profiles in continuous leach ICP-MS (CL-ICP-MS) experiments in soil, linked to REE profiles in surface water in the Koiliaris River Critical Zone Observatory (CZO), Crete, Greece.

  16. Linking Ecological, Environmental and Biogeochemical Data with Multi'omics Analysis

    Science.gov (United States)

    Hasler-Sheetal, H.; Castorani, M. C.; Fragner, L.; Zeng, Y.; Holmer, M.; Glud, R. N.; Weckwerth, W.; Canfield, D. E.

    2016-02-01

    The integrated analysis of multi'omics and environmental data provides a holistic understanding of biological processes and has been proven to be challenging. Here we present our research concept for conducting multi-omics experiments and linking them to environmental data. Hypoxia, reduced light availability and species interaction - all amplified by global warming - cause a global decline of seagrasses. Metabolic mechanisms for coping with these global threats are largely unknown and multi'omics approaches can be an important approach for generating this insight. We applied GC, LC-qTOF-MS and bioinformatics to investigate the effects of environmental pressure on metabolites present in seagrasses. In a first experiment we assessed the metabolomics response of the seagrass Zostera marina towards anoxia and showed that photosynthetically derived oxygen could satisfy the oxygen demand in the leaves. But accumulation of fermentation products in the roots showed that the rhizosphere was under anoxic stress. In contrast nocturnal anoxia caused a biphasic shift in the metabolome of roots and leaves. This nocturnal reprogramming of the metabolome under anoxia indicates a mitigation mechanism to avoid the toxic effects. A pathway enrichment analysis proposes the alanine shunt, the GABA shunt and the 2-oxoglutarate shunt as such mitigation mechanisms that alleviate pyruvate levels and lead to carbon and nitrogen storage during anoxia. In a second experiment, varying light exposure and species interaction of Z. marina with the blue mussel Mytilus edulis - a co-occurring species in seagrass systems - resulted in treatment specific metabolic fingerprints in seagrass. Light modified the metabolic fingerprint expressed in Z. marina to the presence of mussels, indicating varying physiological responses to mussels in normal and low light regimes. Multivariate data-analysis indicated light exposure as main driver (45%) and mussel presence as minor driver (13%) for the metabolic

  17. Cross-linked Polyelectrolyte and Its Function in Adsorption of Fluid and Excess Nitrogen Waste Products: an Experimental Study on Dialysate Effluent Fluid.

    Science.gov (United States)

    Tayebi Khosroshahi, Hamid; Abedi, Behzad; Daneshvar, Sabalan; Alizadeh, Effat; Khalilzadeh, Mohammadreza; Abedi, Yaghoub

    2017-07-01

    One of the most important issues in patients with chronic kidney disease is fluid retention and volume overload accompanied by retention of nitrogenous waste products and some electrolytes. Bowel fluid contains high levels of urea, creatinine, uric acid, and electrolytes, which make it a potential candidate for intestinal excretion of nitrogen wastes and electrolytes. Cross-linked polyelectrolyte (CLP) is a polymer that, given orally, absorbs excess fluid, electrolyte, and nitrogenous waste products. In an experimental study on 30 hemodialysis patients, the effect of CLP on adsorption of fluid, urea, creatinine, uric acid, sodium, and potassium were evaluated. For this purpose, 500 mL of effluent fluid of each patient were collected at the 1st hour of dialysis. The concentrations of the abovementioned products were measured by standard methods. Then the dialysate effluent samples were treated with 6 g of CLP and incubated for 4 hours at 37°C. Up to 80% of effluent fluid water was adsorbed by CLP. There were significant reductions in urea, creatinine, uric acid, and sodium levels in the remaining effluent fluid (P substitute for conventional dialysis methods, especially hemodialysis.

  18. Procedure for statistical analysis of one-parameter discrepant experimental data.

    Science.gov (United States)

    Badikov, Sergey A; Chechev, Valery P

    2012-09-01

    A new, Mandel-Paule-type procedure for statistical processing of one-parameter discrepant experimental data is described. The procedure enables one to estimate a contribution of unrecognized experimental errors into the total experimental uncertainty as well as to include it in analysis. A definition of discrepant experimental data for an arbitrary number of measurements is introduced as an accompanying result. In the case of negligible unrecognized experimental errors, the procedure simply reduces to the calculation of the weighted average and its internal uncertainty. The procedure was applied to the statistical analysis of half-life experimental data; Mean half-lives for 20 actinides were calculated and results were compared to the ENSDF and DDEP evaluations. On the whole, the calculated half-lives are consistent with the ENSDF and DDEP evaluations. However, the uncertainties calculated in this work essentially exceed the ENSDF and DDEP evaluations for discrepant experimental data. This effect can be explained by adequately taking into account unrecognized experimental errors. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Comparative mapping of canine and human proximal Xq and genetic analysis of canine X-linked severe combined immunodeficiency

    Energy Technology Data Exchange (ETDEWEB)

    Deschenes, S.M.; Puck, J.M.; Dutra, A.S. [Univ. of Pennsylvania School of Medicine and Children`s Hospital of Philadelphia, PA (United States)] [and others

    1994-09-01

    Parallel genetic analysis of animal and human genetic diseases can facilitate the identification and characterization of the causative gene defects. For example, canine X-linked severe combined immunodeficiency (SCID) is characterized by clinical, pathological, and immunological manifestations similar to the most common form of human SCID. To derive a canine syntenic map including genes that in humans are located in proximal Xq, near human X-linked SCID, poly (TG) polymorphisms were identified at the canine phosphoglycerate kinase (PGK) and choroideremia (CHM) loci. These plus a polymorphic poly (CAG) sequence in exon 1 of the canine androgen receptor gene (AR) were used to genotype members of the colony informative for X-linked SCID. No recombinations among SCIDX1, AR, PGK, or CHM were observed. Fluorescence in situ hybridization localized PGK and CHM to proximal Xq in the dog, in the same chromosomal location occupied by the human genes. Somatic cell hybrid analysis and methylation differences at AR demonstrated that female dogs carrying X-linked SCID have the same lymphocyte-limited skewed X-chromosome inactivation patterns as human carriers. These genetic and phenotypic findings provide evidence that mutations in the same gene, now identified as the {gamma} chain of the IL-2 receptor, cause canine and human X-linked SCID. This approach is an efficient method for comparative gene mapping and disease identification. 35 refs., 4 figs., 1 tab.

  20. Developing a Multiplexed Quantitative Cross-Linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes.

    Science.gov (United States)

    Yu, Clinton; Huszagh, Alexander; Viner, Rosa; Novitsky, Eric J; Rychnovsky, Scott D; Huang, Lan

    2016-10-18

    Cross-linking mass spectrometry (XL-MS) represents a recently popularized hybrid methodology for defining protein-protein interactions (PPIs) and analyzing structures of large protein assemblies. In particular, XL-MS strategies have been demonstrated to be effective in elucidating molecular details of PPIs at the peptide resolution, providing a complementary set of structural data that can be utilized to refine existing complex structures or direct de novo modeling of unknown protein structures. To study structural and interaction dynamics of protein complexes, quantitative cross-linking mass spectrometry (QXL-MS) strategies based on isotope-labeled cross-linkers have been developed. Although successful, these approaches are mostly limited to pairwise comparisons. In order to establish a robust workflow enabling comparative analysis of multiple cross-linked samples simultaneously, we have developed a multiplexed QXL-MS strategy, namely, QMIX (Quantitation of Multiplexed, Isobaric-labeled cross (X)-linked peptides) by integrating MS-cleavable cross-linkers with isobaric labeling reagents. This study has established a new analytical platform for quantitative analysis of cross-linked peptides, which can be directly applied for multiplexed comparisons of the conformational dynamics of protein complexes and PPIs at the proteome scale in future studies.

  1. Fuzzy logic analysis optimizations for pattern recognition - Implementation and experimental results

    Science.gov (United States)

    Hires, Matej; Habiballa, Hashim

    2017-07-01

    The article presents an practical results of optimization of the fuzzy logic analysis method for pattern recognition. The theoretical background of the proposed theory is shown in the former article extending the original fuzzy logic analysis method. This article shows the implementation and experimental verification of the approach.

  2. Experimental analysis of the steady-state behaviour of beam systems with discontinuous support

    NARCIS (Netherlands)

    Vorst, E.L.B. van de; Campen, D.H. van; Kraker, A. de; Fey, R.H.B.

    1996-01-01

    This paper deals with the experimental analysis of the long-term behaviour of periodically excited linear beams supported by a one-sided spring or an elastic stop. Numerical analysis of the beams showed subharmonic, quasi-periodic and chaotic behaviour. Furthermore, in the beam system with the

  3. X-linked adrenoleukodystrophy: molecular and functional analysis of the ABCD1 gene in Argentinean patients.

    Directory of Open Access Journals (Sweden)

    Cyntia Anabel Amorosi

    Full Text Available X-linked adrenoleukodystrophy (X-ALD is an inherited metabolic disease associated with mutations in the ABCD1 gene that encodes an ATP-binding cassette transporter protein, ALDP. The disease is characterized by increased concentrations of very long-chain fatty acids (VLCFAs in plasma and in adrenal, testicular and nervous tissues, due to a defect in peroxisomal VLCFA β-oxidation. In the present study, we analyzed 10 male patients and 17 female carriers from 10 unrelated pedigrees with X-ALD from Argentina. By sequencing the ABCD1 we detected 9 different mutations, 8 of which were novel. These new mutations were verified by a combination of methods that included both functional (western blot and peroxisomal VLCFA β-oxidation and bioinformatics analysis. The spectrum of novel mutations consists of 3 frameshift (p.Ser284fs*16, p.Glu380Argfs*21 and p.Thr254Argfs*82; a deletion (p.Ser572_Asp575del; a splicing mutation (c.1081+5G>C and 3 missense mutations (p.Ala341Asp, p.His420Pro and p.Tyr547Cys. In one patient 2 changes were found: a known missense (p.His669Arg and an unpublished amino acid substitution (p.Ala19Ser. In vitro studies suggest that p.Ala19Ser is a polymorphism. Moreover, we identified two novel intronic polymorphisms and two amino acid polymorphisms. In conclusion, this study extends the spectrum of mutation in X-ALD and facilitates the identification of heterozygous females.

  4. X-Linked Adrenoleukodystrophy: Molecular and Functional Analysis of the ABCD1 Gene in Argentinean Patients

    Science.gov (United States)

    Amorosi, Cyntia Anabel; Myskóva, Helena; Monti, Mariela Roxana; Argaraña, Carlos Enrique; Morita, Masashi; Kemp, Stephan; de Kremer, Raquel Dodelson; Dvoráková, Lenka; de Ramírez, Ana María Oller

    2012-01-01

    X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disease associated with mutations in the ABCD1 gene that encodes an ATP-binding cassette transporter protein, ALDP. The disease is characterized by increased concentrations of very long-chain fatty acids (VLCFAs) in plasma and in adrenal, testicular and nervous tissues, due to a defect in peroxisomal VLCFA β-oxidation. In the present study, we analyzed 10 male patients and 17 female carriers from 10 unrelated pedigrees with X-ALD from Argentina. By sequencing the ABCD1 we detected 9 different mutations, 8 of which were novel. These new mutations were verified by a combination of methods that included both functional (western blot and peroxisomal VLCFA β-oxidation) and bioinformatics analysis. The spectrum of novel mutations consists of 3 frameshift (p.Ser284fs*16, p.Glu380Argfs*21 and p.Thr254Argfs*82); a deletion (p.Ser572_Asp575del); a splicing mutation (c.1081+5G>C) and 3 missense mutations (p.Ala341Asp, p.His420Pro and p.Tyr547Cys). In one patient 2 changes were found: a known missense (p.His669Arg) and an unpublished amino acid substitution (p.Ala19Ser). In vitro studies suggest that p.Ala19Ser is a polymorphism. Moreover, we identified two novel intronic polymorphisms and two amino acid polymorphisms. In conclusion, this study extends the spectrum of mutation in X-ALD and facilitates the identification of heterozygous females. PMID:23300730

  5. Frames as visual links between paintings and the museum environment: an analysis of statistical image properties

    Science.gov (United States)

    Redies, Christoph; Groß, Franziska

    2013-01-01

    Frames provide a visual link between artworks and their surround. We asked how image properties change as an observer zooms out from viewing a painting alone, to viewing the painting with its frame and, finally, the framed painting in its museum environment (museum scene). To address this question, we determined three higher-order image properties that are based on histograms of oriented luminance gradients. First, complexity was measured as the sum of the strengths of all gradients in the image. Second, we determined the self-similarity of histograms of the orientated gradients at different levels of spatial analysis. Third, we analyzed how much gradient strength varied across orientations (anisotropy). Results were obtained for three art museums that exhibited paintings from three major periods of Western art. In all three museums, the mean complexity of the frames was higher than that of the paintings or the museum scenes. Frames thus provide a barrier of complexity between the paintings and their exterior. By contrast, self-similarity and anisotropy values of images of framed paintings were intermediate between the images of the paintings and the museum scenes, i.e., the frames provided a transition between the paintings and their surround. We also observed differences between the three museums that may reflect modified frame usage in different art periods. For example, frames in the museum for 20th century art tended to be smaller and less complex than in the two other two museums that exhibit paintings from earlier art periods (13th–18th century and 19th century, respectively). Finally, we found that the three properties did not depend on the type of reproduction of the paintings (photographs in museums, scans from books or images from the Google Art Project). To the best of our knowledge, this study is the first to investigate the relation between frames and paintings by measuring physically defined, higher-order image properties. PMID:24265625

  6. Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease.

    Science.gov (United States)

    Douvris, Adrianna; Soubeyrand, Sébastien; Naing, Thet; Martinuk, Amy; Nikpay, Majid; Williams, Andrew; Buick, Julie; Yauk, Carole; McPherson, Ruth

    2014-06-03

    The TRIB1 locus has been linked to hepatic triglyceride metabolism in mice and to plasma triglycerides and coronary artery disease in humans. The lipid-associated single nucleotide polymorphisms (SNPs), identified by genome-wide association studies, are located ≈30 kb downstream from TRIB1, suggesting complex regulatory effects on genes or pathways relevant to hepatic triglyceride metabolism. The goal of this study was to investigate the functional relationship between common SNPs at the TRIB1 locus and plasma lipid traits. Characterization of the risk locus reveals that it encompasses a gene, TRIB1-associated locus (TRIBAL), composed of a well-conserved promoter region and an alternatively spliced transcript. Bioinformatic analysis and resequencing identified a single SNP, rs2001844, within the promoter region that associates with increased plasma triglycerides and reduced high-density lipoprotein cholesterol and coronary artery disease risk. Further, correction for triglycerides as a covariate indicated that the genome-wide association studies association is largely dependent on triglycerides. In addition, we show that rs2001844 is an expression trait locus (eQTL) for TRIB1 expression in blood and alters TRIBAL promoter activity in a reporter assay model. The TRIBAL transcript has features typical of long noncoding RNAs, including poor sequence conservation. Modulation of TRIBAL expression had limited impact on either TRIB1 or lipid regulatory genes mRNA levels in human hepatocyte models. In contrast, TRIB1 knockdown markedly increased TRIBAL expression in HepG2 cells and primary human hepatocytes. These studies demonstrate an interplay between a novel locus, TRIBAL, and TRIB1. TRIBAL is located in the genome-wide association studies identified risk locus, responds to altered expression of TRIB1, harbors a risk SNP that is an eQTL for TRIB1 expression, and associates with plasma triglyceride concentrations. © 2014 The Authors. Published on behalf of the

  7. Link Analysis of High Throughput Spacecraft Communication Systems for Future Science Missions

    Science.gov (United States)

    Simons, Rainee N.

    2015-01-01

    NASA's plan to launch several spacecrafts into low Earth Orbit (LEO) to support science missions in the next ten years and beyond requires down link throughput on the order of several terabits per day. The ability to handle such a large volume of data far exceeds the capabilities of current systems. This paper proposes two solutions, first, a high data rate link between the LEO spacecraft and ground via relay satellites in geostationary orbit (GEO). Second, a high data rate direct to ground link from LEO. Next, the paper presents results from computer simulations carried out for both types of links taking into consideration spacecraft transmitter frequency, EIRP, and waveform; elevation angle dependent path loss through Earths atmosphere, and ground station receiver GT.

  8. Analysis of protein-nucleic acid interactions by photochemical cross-linking and mass spectrometry

    DEFF Research Database (Denmark)

    Steen, Hanno; Jensen, Ole Nørregaard

    2002-01-01

    and for sequencing of peptide-nucleic acid heteroconjugates. The combination of photochemical cross-linking and MS provides a fast screening method to gain insights into the overall structure and formation of protein-oligonucleotide complexes. Because the analytical methods are continuously refined and protein...... structural data are rapidly accumulating in databases, we envision that many protein-nucleic acid assemblies will be initially characterized by combinations of cross-linking methods, MS, and computational molecular modeling....

  9. Beliefs and ideologies linked with approval of corporal punishment: a content analysis of online comments

    OpenAIRE

    Taylor, C. A.; Al-Hiyari, R.; Lee, S. J.; Priebe, A.; Guerrero, L. W.; Bales, A.

    2016-01-01

    This study employs a novel strategy for identifying points of resistance to education efforts aimed at reducing rates of child physical abuse and use of corporal punishment (CP). We analyzed online comments (n = 581) generated in response to media coverage of a study linking CP with increased child aggression. Most comments (71%) reflected approval of hitting children for disciplinary purposes. Reasons for this approval were rooted in beliefs linking the use of CP with positive or neutral out...

  10. Analysis of Proximity-1 Space Link Interleaved Time Synchronization (PITS) Protocol

    Science.gov (United States)

    Woo, Simon S.

    2011-01-01

    To synchronize clocks between spacecraft in proximity, the Proximity-1 Space Link Interleaved Time Synchronization (PITS) Protocol has been proposed. PITS is based on the NTP Interleaved On-Wire Protocol and is capable of being adapted and integrated into CCSDS Proximity-1 Space Link Protocol with minimal modifications. In this work, we will discuss the correctness and liveness of PITS. Further, we analyze and evaluate the performance of time synchronization latency with various channel error rates in different PITS operational modes.

  11. Link Performance Analysis of a Ship-to-Ship Laser Communication System

    Science.gov (United States)

    2012-03-01

    helium- neon (HeNe), carbon dioxide (CO2), and argon (Ar), to produce a coherent light. The dye laser is produced by directing a high-energy source of...molecules in the atmosphere that contribute to absorption are the oxygen (O2), nitrogen (N2), carbon 28 dioxide (CO2), argon (Ar), methane (CH4...error rate and explains the parameters of the link budget. The fifth chapter provides an example of a link budget calculation and discusses the

  12. Biophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemia.

    Directory of Open Access Journals (Sweden)

    Dimitra Georgiadou

    Full Text Available Apolipoprotein E (apoE is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and protection from atherosclerosis. ApoE is characterized by structural plasticity and thermodynamic instability and can undergo significant structural rearrangements as part of its biological function. Mutations in the 136-150 region of the N-terminal domain of apoE, reduce its low density lipoprotein (LDL receptor binding capacity and have been linked with lipoprotein disorders, such as type III hyperlipoproteinemia (HLP in humans. However, the LDL-receptor binding defects for these apoE variants do not correlate well with the severity of dyslipidemia, indicating that these variants may carry additional properties that contribute to their pathogenic potential.In this study we examined whether three type III HLP predisposing apoE3 variants, namely R136S, R145C and K146E affect the biophysical properties of the protein. Circular dichroism (CD spectroscopy revealed that these mutations do not significantly alter the secondary structure of the protein. Thermal and chemical unfolding analysis revealed small thermodynamic alterations in each variant compared to wild-type apoE3, as well as effects in the reversibility of the unfolding transition. All variants were able to remodel multillamelar 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC vesicles, but R136S and R145C had reduced kinetics. Dynamic light scattering analysis indicated that the variant R136S exists in a higher-order oligomerization state in solution. Finally, 1-anilinonaphthalene-8-sulfonic acid (ANS binding suggested that the variant R145C exposes a larger amount of hydrophobic surface to the solvent.Overall, our findings suggest that single amino acid changes in the functionally important region 136-150 of apoE3 can affect the molecule's stability and conformation in solution and may underlie functional consequences. However, the magnitude and the non

  13. Exoproteome analysis reveals higher abundance of proteins linked to alkaline stress in persistent Listeria monocytogenes strains.

    Science.gov (United States)

    Rychli, Kathrin; Grunert, Tom; Ciolacu, Luminita; Zaiser, Andreas; Razzazi-Fazeli, Ebrahim; Schmitz-Esser, Stephan; Ehling-Schulz, Monika; Wagner, Martin

    2016-02-02

    The foodborne pathogen Listeria monocytogenes, responsible for listeriosis a rare but severe infection disease, can survive in the food processing environment for month or even years. So-called persistent L. monocytogenes strains greatly increase the risk of (re)contamination of food products, and are therefore a great challenge for food safety. However, our understanding of the mechanism underlying persistence is still fragmented. In this study we compared the exoproteome of three persistent strains with the reference strain EGDe under mild stress conditions using 2D differential gel electrophoresis. Principal component analysis including all differentially abundant protein spots showed that the exoproteome of strain EGDe (sequence type (ST) 35) is distinct from that of the persistent strain R479a (ST8) and the two closely related ST121 strains 4423 and 6179. Phylogenetic analyses based on multilocus ST genes showed similar grouping of the strains. Comparing the exoproteome of strain EGDe and the three persistent strains resulted in identification of 22 differentially expressed protein spots corresponding to 16 proteins. Six proteins were significantly increased in the persistent L. monocytogenes exoproteomes, among them proteins involved in alkaline stress response (e.g. the membrane anchored lipoprotein Lmo2637 and the NADPH dehydrogenase NamA). In parallel the persistent strains showed increased survival under alkaline stress, which is often provided during cleaning and disinfection in the food processing environments. In addition, gene expression of the proteins linked to stress response (Lmo2637, NamA, Fhs and QoxA) was higher in the persistent strain not only at 37 °C but also at 10 °C. Invasion efficiency of EGDe was higher in intestinal epithelial Caco2 and macrophage-like THP1 cells compared to the persistent strains. Concurrently we found higher expression of proteins involved in virulence in EGDe e.g. the actin-assembly-inducing protein ActA and the

  14. Biomechanical property analysis after corneal collagen cross-linking in relation to ultraviolet A irradiation time.

    Science.gov (United States)

    Lanchares, Elena; del Buey, María Angeles; Cristóbal, José Angel; Lavilla, Laura; Calvo, Begoña

    2011-08-01

    To study the biomechanical effect of riboflavin-ultraviolet A irradiation (UVA)-induced collagen cross-linking (CXL) in porcine corneas using two different exposure times of 30 and 60 min. Seventeen enucleated porcine eyes were divided into three groups: group A, six eyes without any treatment, group B, six eyes treated by UVA CXL for 30 min, and group C, five eyes treated by UVA CXL for 60 min. Riboflavin (vitamin B2) was used as a photosensitizer in both groups of treatment. Then, the stress-strain behavior of all the specimens was measured to compare the corneal biomechanical properties among the three groups. The Young's modulus E of the mean curve of each group shows the stiffness of treated and untreated tissue. The stress data necessary for stretches of 6, 8, and 12% were used to perform the statistical analysis of the values. Group B (riboflavin-UVA-CXL, 30 min, E = 46 MPa) showed a stiffer behavior than group A (control, E = 29 MPa) . Group C (60 min CXL, E = 28 MPa) showed lower stiffness than group B and a similar mechanical behavior than group A. The statistical analysis of the stress-strain curves showed significant differences in the corneal response between group B and the control at the three values of stretch considered, 6, 8, and 12% (p = 0.025, p = 0.025 and p = 0.037, respectively) and between group B and group C (p = 0.028, p = 0.028, and p = 0.028). No statistically significant difference was found between group C and control (p = 0.855, p = 0.715, and p = 0.584). The application of 30-min UVA CXL treatment with riboflavin increased stiffness of the porcine corneal tissue. A 60-min UVA-radiated tissue presents lower stiffness than the 30-min treated tissue, showing a similar biomechanical behavior than the untreated corneas. A prolongation of the UVA irradiation time may cause structural weakening of the porcine corneas.

  15. COMPARATIVE ANALYSIS OF THE MAIN UNIT-LINKED INVESTMENT PROGRAMS PROPOSED BY THE ROMANIAN LIFE INSURANCE COMPANIES

    Directory of Open Access Journals (Sweden)

    CIUMAS Cristina

    2017-06-01

    Full Text Available An important component of the activity carried out by the insurance companies is the investment of the premiums paid by policyholders in various types of assets, in order to obtain higher yields than those guaranteed by the insurance contracts, while providing the necessary liquidity for the payment of insurance claims in case of occurrence of the assumed risks. This research contributes to the existing literature regarding the study of investment alternatives, with an exclusive focus on the investment in unit-linked life insurance. A special place in this study is the comparative analysis of the main unit-linked investment programs offered by Romanian insurance companies.

  16. Marker list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...isition method The information of markers was collected from other databases and/or papers. Data analysis me...Database Site Policy | Contact Us Marker list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  17. An Experimental and Numerical Analysis of Refrigerant Flow Inside the Suction Muffler of Hermetic Reciprocating Compressor

    OpenAIRE

    Sarioglu, Dr. Kemal; Ozdemir, Ahmet Refik; Oguz, Emre; KAYA, Atilla

    2012-01-01

    In this study, detailed temperature and pressure measurements were performed at the inlet, outlet and outer boundaries of the suction muffler of a hermetic reciprocating compressor. The measurements were conducted without effecting real phenomena. After experimental studies, detailed computational fluid dynamic analysis of the refrigerant flow (isobutane) in the suction muffler was performed. Experimental pressure and temperature values at the inlet, outlet and outer boundaries of the suction...

  18. Experimental extractions of particle position from inline holograms using single coefficient of Wigner-Ville analysis

    Science.gov (United States)

    Widjaja, Joewono; Dawprateep, Saowaros; Chuamchaitrakool, Porntip

    2017-07-01

    Extractions of particle positions from inline holograms using a single coefficient of Wigner-Ville distribution (WVD) are experimentally verified. WVD analysis of holograms gives local variation of fringe frequency. Regardless of an axial position of particles, one of the WVD coefficients has the unique characteristics of having the lowest amplitude and being located on a line with a slope inversely proportional to the particle position. Experimental results obtained using two image sensors with different resolutions verify the feasibility of the present method.

  19. Statistical Approaches in Analysis of Variance: from Random Arrangements to Latin Square Experimental Design

    OpenAIRE

    Radu E. SESTRAŞ; Lorentz JÄNTSCHI; Sorana D. BOLBOACĂ

    2009-01-01

    Background: The choices of experimental design as well as of statisticalanalysis are of huge importance in field experiments. These are necessary tobe correctly in order to obtain the best possible precision of the results. Therandom arrangements, randomized blocks and Latin square designs werereviewed and analyzed from the statistical perspective of error analysis.Material and Method: Random arrangements, randomized block and Latinsquares experimental designs were used as field experiments. ...

  20. Experimental spectra analysis in THM with the help of simulation based on Geant4 framework

    CERN Document Server

    Li, Chengbo; Zhou, Shuhua; Fu, Yuanyong; Zhou, Jing; Meng, Qiuying; Jiang, Zongjun; Wang, Xiaolian

    2014-01-01

    The Coulomb barrier and electron screening cause difficulties in directly measuring nuclear reaction cross sections of charged particles in astrophysical energies. The Trojan-horse method has been introduced to solve the difficulties as a powerful indirect tool. In order to understand experimental spectra better, Geant4 is employed to simulate the method for the first time. Validity and reliability of the simulation are examined by comparing the experimental data with simulated results. The Geant4 simulation can give useful information to understand the experimental spectra better in data analysis and is beneficial to the design for future related experiments.

  1. Pathway analysis supports association of nonsyndromic cryptorchidism with genetic loci linked to cytoskeleton-dependent functions.

    Science.gov (United States)

    Barthold, Julia Spencer; Wang, Yanping; Kolon, Thomas F; Kollin, Claude; Nordenskjöld, Agneta; Olivant Fisher, Alicia; Figueroa, T Ernesto; BaniHani, Ahmad H; Hagerty, Jennifer A; Gonzaléz, Ricardo; Noh, Paul H; Chiavacci, Rosetta M; Harden, Kisha R; Abrams, Debra J; Kim, Cecilia E; Li, Jin; Hakonarson, Hakon; Devoto, Marcella

    2015-10-01

    What are the genetic loci that increase susceptibility to nonsyndromic cryptorchidism, or undescended testis? A genome-wide association study (GWAS) suggests that susceptibility to cryptorchidism is heterogeneous, with a subset of suggestive signals linked to cytoskeleton-dependent functions and syndromic forms of the disease. Population studies suggest moderate genetic risk of cryptorchidism and possible maternal and environmental contributions to risk. Previous candidate gene analyses have failed to identify a major associated locus, although variants in insulin-like 3 (INSL3), relaxin/insulin-like family peptide receptor 2 (RXFP2) and other hormonal pathway genes may increase risk in a small percentage of patients. This is a case-control GWAS of 844 boys with nonsyndromic cryptorchidism and 2718 control subjects without syndromes or genital anomalies, all of European ancestry. All boys with cryptorchidism were diagnosed and treated by a pediatric specialist. In the discovery phase, DNA was extracted from tissue or blood samples and genotyping performed using the Illumina HumanHap550 and Human610-Quad (Group 1) or OmniExpress (Group 2) platform. We imputed genotypes genome-wide, and combined single marker association results in meta-analyses for all cases and for secondary subphenotype analyses based on testis position, laterality and age, and defined genome-wide significance as P = 7 × 10(-9) to correct for multiple testing. Selected markers were genotyped in an independent replication group of European cases (n = 298) and controls (n = 324). We used several bioinformatics tools to analyze top (P Cytoskeleton-dependent molecular and cellular functions were prevalent in pathway analysis of suggestive signals, and may implicate loci encoding cytoskeletal proteins that participate in androgen receptor signaling. Genes linked to human syndromic cryptorchidism, including hypogonadotropic hypogonadism, and to hormone-responsive and/or differentially expressed genes

  2. Advances in the indirect, descriptive, and experimental approaches to the functional analysis of problem behavior.

    Science.gov (United States)

    Wightman, Jade; Julio, Flávia; Virués-Ortega, Javier

    2014-05-01

    Experimental functional analysis is an assessment methodology to identify the environmental factors that maintain problem behavior in individuals with developmental disabilities and in other populations. Functional analysis provides the basis for the development of reinforcement-based approaches to treatment. This article reviews the procedures, validity, and clinical implementation of the methodological variations of functional analysis and function-based interventions. We present six variations of functional analysis methodology in addition to the typical functional analysis: brief functional analysis, single-function tests, latency-based functional analysis, functional analysis of precursors, and trial-based functional analysis. We also present the three general categories of function-based interventions: extinction, antecedent manipulation, and differential reinforcement. Functional analysis methodology is a valid and efficient approach to the assessment of problem behavior and the selection of treatment strategies.

  3. Experimental analysis of the influence of damping on the resonance behavior of a spherical pendulum

    Czech Academy of Sciences Publication Activity Database

    Pospíšil, Stanislav; Fischer, Cyril; Náprstek, Jiří

    2014-01-01

    Roč. 78, č. 1 (2014), s. 371-390 ISSN 0924-090X R&D Projects: GA ČR(CZ) GC13-34405J Grant - others:NSC(TW) 101WFD0400131 Institutional support: RVO:68378297 Keywords : auto-parametric system * experimental verification * spherical pendulum * stability of semi-trivial solution Subject RIV: JM - Building Engineering Impact factor: 2.849, year: 2014 http://link.springer.com/article/10.1007%2Fs11071-014-1446-6#page-1

  4. A Contrastive Analysis of the Links of Textuality in Abstracts Written by Persian and English Writers in Clinical Psychology Journals

    Directory of Open Access Journals (Sweden)

    Abbas Mehrabi Boshrabadi

    2014-07-01

    Full Text Available It is generally agreed today that lexical cohesion is one of the fundamental elements of the text texture achieved through lexical semantic relations dominating the arrangement of propositional units in a text. Accordingly, this study sought to compare and contrast the textual links or lexical cohesive devices enlisted in the psychological abstracts written by Persian and English writers. To this end, 40 abstracts from Persian and English articles, 20 in each language, published in clinical psychology journals were randomly selected. The framework serving as tertium comprationis for analyzing lexical cohesion markers was derived from Halliday and Hasan’s (1976 model [Halliday, M. A. K., & Hasan, R. (1976. Cohesion in English. London: Longman]. A frequency count analysis was employed to gauge the number of occurrences of cohesive links in the selected corpus. The results revealed that lexical links of synonymy and repetition were more frequent than other cohesive devices in both English and Persian abstracts.

  5. Analysis of a Combined Antenna Arrays and Reverse-Link Synchronous DS-CDMA System over Multipath Rician Fading Channels

    Directory of Open Access Journals (Sweden)

    Kim Yong-Seok

    2005-01-01

    Full Text Available We present the BER analysis of antenna array (AA receiver in reverse-link asynchronous multipath Rician channels and analyze the performance of an improved AA system which applies a reverse-link synchronous transmission technique (RLSTT in order to effectively make a better estimation of covariance matrices at a beamformer-RAKE receiver. In this work, we provide a comprehensive analysis of user capacity which reflects several important factors such as the ratio of the specular component power to the Rayleigh fading power, the shape of multipath intensity profile, and the number of antennas. Theoretical analysis demonstrates that for the case of a strong specular path's power or for a high decay factor, the employment of RLSTT along with AA has the potential of improving the achievable capacity by an order of magnitude.

  6. Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis

    Directory of Open Access Journals (Sweden)

    Hongmei Chen

    2009-01-01

    Full Text Available We have previously reported the preparation of the genipin cross-linked alginate-chitosan (GCAC microcapsules composed of an alginate core with a genipin cross-linked chitosan membrane. This paper is the further investigation on their structural and physical characteristics. Results showed that the GCAC microcapsules had a smooth and dense surface and a networked interior. Cross-linking by genipin substantially reduced swelling and physical disintegration of microcapsules induced by nongelling ions and calcium sequestrants. Strong resistance to mechanical shear forces and enzymatic degradation was observed. Furthermore, the GCAC membranes were permeable to bovine serum albumin and maintained a molecular weight cutoff at 70 KD, analogous to the widely studied alginate-chitosan, and alginate-poly-L-lysine-alginate microcapsules. The release features and the tolerance of the GCAC microcapsules in the stimulated gastrointestinal environment were also investigated. This GCAC microcapsule formulation offers significant potential as a delivery vehicle for many biomedical applications.

  7. Corrosion analysis in mooring chain links; Analise de corrosao em elos de amarras

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Silvia N.; Pereira, Marcos V. [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil). Dept. de Ciencia dos Materiais e Metalurgia; Costa, Luis C. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil). Centro de Pesquisas; Motta, Sergio H. [Brasilamarras - Companhia Brasileira de Amarras, Niteroi, RJ (Brazil)

    2004-07-01

    The purpose of this work was to characterize the localized corrosion phenomenon in the weld region of offshore mooring chain links type ORQ. In this sense, a number of chain links were selected after finishing their projected life time without corrosion signs (chains without corrosion) as well as chain links which showed a reduced life time caused by localized corrosion (chains with corrosion). In the sequence, electrochemistry tests evaluated the corrosion susceptibility of the different regions of the weld joint. The results showed that the heat affected zone concerning the chains with corrosion was the anodic region, with high corrosion rate, while the same region on the not corroded chains was the cathodic one, with low corrosion rate. (author)

  8. Analysis of fog effects on terrestrial Free Space optical communication links

    KAUST Repository

    Esmail, Maged Abdullah

    2016-07-26

    In this paper, we consider and examine fog measurement data, coming from several locations in Europe and USA, and attempt to derive a unified model for fog attenuation in free space optics (FSO) communication links. We evaluate and compare the performance of our proposed model to that of many well-known alternative models. We found that our proposed model, achieves an average RMSE that outperforms them by more than 9 dB. Furthermore, we have studied the performance of the FSO system using different performance metrics such as signal-to-noise (SNR) ratio, bit error rate (BER), and channel capacity. Our results show that FSO is a short range technology. Therefore, FSO is expected to find its place in future networks that will have small cell size, i.e., <1 km diameter. Moreover, our investigation shows that under dense fog, it is difficult to maintain a communications link because of the high signal attenuation, which requires switching the communications to RF backup. Our results show that increasing the transmitted power will improve the system performance under light fog. However, under heavy fog, the effect is minor. To enhance the system performance under low visibility range, multi-hop link is used which can enhance the power budget by using short segments links. Using 22 dBm transmitted power, we obtained BER=10-3 over 1 km link length with 600 m visibility range which corresponds to light fog. However, under lower visibility range equals 40 m that corresponds to dense fog, we obtained the same BER but over 200 m link length. © 2016 IEEE.

  9. Velo and REXAN - Integrated Data Management and High Speed Analysis for Experimental Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kleese van Dam, Kerstin; Carson, James P.; Corrigan, Abigail L.; Einstein, Daniel R.; Guillen, Zoe C.; Heath, Brandi S.; Kuprat, Andrew P.; Lanekoff, Ingela T.; Lansing, Carina S.; Laskin, Julia; Li, Dongsheng; Liu, Yan; Marshall, Matthew J.; Miller, Erin A.; Orr, Galya; Pinheiro da Silva, Paulo; Ryu, Seun; Szymanski, Craig J.; Thomas, Mathew

    2013-01-10

    The Chemical Imaging Initiative at the Pacific Northwest National Laboratory (PNNL) is creating a ‘Rapid Experimental Analysis’ (REXAN) Framework, based on the concept of reusable component libraries. REXAN allows developers to quickly compose and customize high throughput analysis pipelines for a range of experiments, as well as supporting the creation of multi-modal analysis pipelines. In addition, PNNL has coupled REXAN with its collaborative data management and analysis environment Velo to create an easy to use data management and analysis environments for experimental facilities. This paper will discuss the benefits of Velo and REXAN in the context of three examples: PNNL High Resolution Mass Spectrometry - reducing analysis times from hours to seconds, and enabling the analysis of much larger data samples (100KB to 40GB) at the same time · ALS X-Ray tomography - reducing analysis times of combined STXM and EM data collected at the ALS from weeks to minutes, decreasing manual work and increasing data volumes that can be analysed in a single step ·Multi-modal nano-scale analysis of STXM and TEM data - providing a semi automated process for particle detection The creation of REXAN has significantly shortened the development time for these analysis pipelines. The integration of Velo and REXAN has significantly increased the scientific productivity of the instruments and their users by creating easy to use data management and analysis environments with greatly reduced analysis times and improved analysis capabilities.

  10. Fluorescent Analysis of Photosynthetic Microbes and Polycyclic Aromatic Hydrocarbons Linked to Optical Remote Sensing

    Science.gov (United States)

    Zhang, D.; Muller, J.-P.; Lavender, S.; Walton, D.; Dartnell, L. R.

    2012-07-01

    Fluorescence analysis, being a non-invasive technique, has become one of the most powerful and widely used techniques for microbiologists and chemists to study various types of sample from photosynthetic microbes to hydrocarbons. The work reported here focuses on experimental results of fluorescent features of photosynthetic microbial species (cyanobacteria) and also five different crude oil samples. The cyanobacteria samples were collected from the Baltic Sea at the end of July 2011 and were associated with cyanobacterial bloom events, and the crude oil samples were from various oil spill events. The aim of the study was to find fluorescent biosignatures of cyanobacteria (initially a species specific to the Baltic Sea) and the fingerprints of crude oil; oil spills can be difficult to differentiate from biogenic films when using Synthetic Aperture Radar (SAR) or sunglint contaminated optical imagery. All samples were measured using a Perkin Elmer LS55 Luminescence spectrometer over a broad range of excitation and emission wavelength from ultraviolet (UV) to near infrared (NIR). The results are presented in Excitation Emission Matrices (EEMs) that exhibit the fluorescent features of each sample. In the EEM of the seawater sample containing cyanobacteria, there is an intense emission peak from tryptophan with fluorescent excitation and emission peaks at 285 and 345 nm respectively. In addition, fluorescent signatures of phycocyanin and chlorophyll-a are present with excitation and emission centre wavelengths at 555 nm, 645 nm and 390 nm, 685 nm, respectively. Additionally, the fluorescence signatures of Polycyclic Aromatic Hydrocarbons (PAHs) are present in the EEMs of crude oil samples with excitation and emission peaks at 285 nm and 425 nm. This study underpins further research on how to distinguish cyanobacteria species by their fluorescence signatures and the potential role that PAHs play in detection of cyanobacteria fluorescence features.

  11. 3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements.

    Science.gov (United States)

    Stadelmann, Vincent A; Hocke, Jean; Verhelle, Jensen; Forster, Vincent; Merlini, Francesco; Terrier, Alexandre; Pioletti, Dominique P

    2009-02-01

    A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed at the zone of highest mechanical stimulus to maximise the measured effects. Accordingly, it is proposed that quantification of bone remodelling should be performed at the tibial crest and at the distal diaphysis. The numerical model could also be used to furnish a more subtle analysis as a precise correlation between local strain and local biological response can be obtained with the experimentally validated numerical model.

  12. Registered plant list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...tabases and/or the genomic analysis information. Data file File name: pgdbj_dna_marker_linkage_map_plant_spe...ion method The information related to each organism was collected from databases, papers, and/or reveiews. Data analysis...the Plant DB link list in simple search page) Genome analysis methods Presence or absence of Genome analys...is methods information in this DB (link to the Genome analysis methods information

  13. An explorative analysis of the links between learning behavior and change orientation

    NARCIS (Netherlands)

    Sluis, van der E.C. (Lidewey); Caluwé, L.I.A.; Nistelrooij, van A.T.M.

    2005-01-01

    The article presents an explorative study on the links between learning behavior and change orientation of individuals. When reading literature on how to develop employees and organizations, it strikes one how less focus there is on learning and change needs of individuals. This paper deals with

  14. Bulked segregant analysis identifies molecular markers linked to Melampsora medusae resistance in Populus deltoides

    Science.gov (United States)

    G. M. Tabor; Thomas L. Kubisiak; N. B. Klopfenstein; R. B. Hall; Henry S. McNabb

    2000-01-01

    In the north central United States, leaf rust caused by Melampsora medusae is a major disease problem on Populus deltoides. In this study we identified molecular markers linked to a M. medusae resistance locus (Lrd1) that was segregating 1:1 within an intraspecific P. deltoides...

  15. Beliefs and Ideologies Linked with Approval of Corporal Punishment: A Content Analysis of Online Comments

    Science.gov (United States)

    Taylor, C. A.; Al-Hiyari, R.; Lee, S. J.; Priebe, A.; Guerrero, L. W.; Bales, A.

    2016-01-01

    This study employs a novel strategy for identifying points of resistance to education efforts aimed at reducing rates of child physical abuse and use of corporal punishment (CP). We analyzed online comments (n = 581) generated in response to media coverage of a study linking CP with increased child aggression. Most comments (71%) reflected…

  16. Revisiting the Gun Ownership and Violence Link; a multi- level analysis of victimisation survey data.

    NARCIS (Netherlands)

    van Kesteren, J.N.

    2014-01-01

    The link between gun ownership victimisation by violent crime remains one of the most contested issues in criminology. Some authors claim that high gun availability facilitates serious violence. Others claim that gun ownership prevents crime. This article revisits these issues using individual and

  17. Linking Adverbials in First-Year Korean University EFL Learners' Writing: A Corpus-Informed Analysis

    Science.gov (United States)

    Ha, Myung-Jeong

    2016-01-01

    This study examines the frequency and usage patterns of linking adverbials in Korean students' essay writing in comparison with native English writing. The learner corpus used in the present study is composed of 105 essays that were produced by first-year university students in Korea. The control corpus was taken from the American LOCNESS…

  18. Neuroticism, a central link between somatic and psychiatric morbidity : path analysis of prospective data

    NARCIS (Netherlands)

    Neeleman, J; Bijl, R; Ormel, J

    Background. Neuroticism and somatic complaints are linked, and the aim of this study is to disentangle which mechanisms may be responsible for this association. Method. In a stratified sample of 7076 adults (18-65 years), neuroticism, 22 self-reported chronic somatic conditions and five broad

  19. Link Budget Analysis and Modeling of Short-Range UWB Channels

    NARCIS (Netherlands)

    Irahhauten, Z.; Dacuna, J.; Janssen, G.J.M.; Nikookar, H.; Yarovoy, A.G.; Ligthart, L.P.

    2008-01-01

    Ultrawideband (UWB) technology is an attractive alternative for short-range applications, e.g., wireless personal area networks. In these applications, transmit and receive antennas are very close to each other and the far-field condition assumed in most of the link budget models may not be

  20. Linking Material Flow Analysis with Resilience Using Rice: A Case Study in Global, Visual MFA of a Key Food Product

    OpenAIRE

    Michal Monit; André Pina; Paulo Ferrão

    2016-01-01

    This article uses the rice price crisis of 2007–2008 to show how material flow analysis (MFA) can be combined with resilience research. After presentation of fundamental information and methods, resilience-related concepts are illustrated using graphical methods and MFA data. Herfindahl-Hirschman Index (HHI) and node-link diagrams are used to highlight potential vulnerability hotspots and show response to, recovery from disturbance and adaptation following a disruption of the global rice mark...

  1. Analysis and presentation of experimental results with examples, problems and programs

    CERN Document Server

    Christodoulides, Costas

    2017-01-01

    This book is intended as a guide to the analysis and presentation of experimental results. It develops various techniques for the numerical processing of experimental data, using basic statistical methods and the theory of errors. After presenting basic theoretical concepts, the book describes the methods by which the results can be presented, both numerically and graphically. The book is divided into three parts, of roughly equal length, addressing the theory, the analysis of data, and the presentation of results. Examples are given and problems are solved using the Excel, Origin, Python and R software packages. In addition, programs in all four languages are made available to readers, allowing them to use them in analyzing and presenting the results of their own experiments. Subjects are treated at a level appropriate for undergraduate students in the natural sciences, but this book should also appeal to anyone whose work involves dealing with experimental results.

  2. Theoretical analysis and experimental measurement for resonant vibration of piezoceramic circular plates.

    Science.gov (United States)

    Huang, Chi-Hung; Lin, Yu-Chih; Ma, Chien-Ching

    2004-01-01

    Based on the electroelastic theory for piezoelectric plates, the vibration characteristics of piezoceramic disks with free-boundary conditions are investigated in this work by theoretical analysis, numerical simulation, and experimental measurement. The resonance of thin piezoceramic disks is classified into three types of vibration modes: transverse, tangential, and radial extensional modes. All of these modes are investigated in detail. Two optical techniques, amplitude-fluctuation electronic speckle pattern interferometry (AF-ESPI) and laser Doppler vibrometer (LDV), are used to validate the theoretical analysis. Because the clear fringe patterns are shown only at resonant frequencies, both the resonant frequencies and the corresponding mode shapes are obtained experimentally at the same time by the proposed AF-ESPI method. Good quality of the interferometric fringe patterns for both the transverse and extensional vibration mode shapes are demonstrated. The resonant frequencies of the piezoceramic disk also are measured by the conventional impedance analysis. Both theoretical and experimental results indicate that the transverse and tangential vibration modes cannot be measured by the impedance analysis, and only the resonant frequencies of extensional vibration modes can be obtained. Numerical calculations based on the finite element method also are performed, and the results are compared with the theoretical analysis and experimental measurements. It is shown that the finite element method (FEM) calculations and the experimental results agree fairly well for the resonant frequencies and mode shapes. The resonant frequencies and mode shapes predicted by theoretical analysis and calculated by finite element method are in good agreement, and the difference of resonant frequencies for both results with the thickness-to-diameter (h/D) ratios, ranging from 0.01 to 0.1, are presented.

  3. Design of high-bit-rate coherent communication links

    Science.gov (United States)

    Konyshev, V. A.; Leonov, A. V.; Nanii, O. E.; Novikov, A. G.; Treshchikov, V. N.; Ubaydullaev, R. R.

    2016-12-01

    We report an analysis of the problems encountered in the design of modern high-bit-rate coherent communication links. A phenomenological communication link model is described, which is suitable for solving applied tasks of the network design with nonlinear effects taken into account. We propose an engineering approach to the design that is based on the use of fundamental nonlinearity coefficients calculated in advance for the experimental configurations of communication links. An experimental method is presented for calculating the nonlinearity coefficient of communication links. It is shown that the proposed approach allows one to successfully meet the challenges in designing communication networks.

  4. Testing for Questionable Research Practices in a Meta-Analysis: An Example from Experimental Parapsychology

    OpenAIRE

    Bierman, Dick J.; Spottiswoode, James P.; Aron Bijl

    2016-01-01

    We describe a method of quantifying the effect of Questionable Research Practices (QRPs) on the results of meta-analyses. As an example we simulated a meta-analysis of a controversial telepathy protocol to assess the extent to which these experimental results could be explained by QRPs. Our simulations used the same numbers of studies and trials as the original meta-analysis and the frequencies with which various QRPs were applied in the simulated experiments were based on surveys of experime...

  5. The Etymology of Basic Concepts in the Experimental Analysis of Behavior

    Science.gov (United States)

    Dinsmoor, James A.

    2004-01-01

    The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his…

  6. "Golden Oldies" in a Laboratory Course in the Experimental Analysis of Behavior

    Science.gov (United States)

    Zuriff, G. E.

    2005-01-01

    A common problem in teaching undergraduate courses in the experimental analysis of behavior (EAB) is that the contemporary research literature is largely not comprehensible to most undergraduates. A suggested solution is the use of research articles from the early days of EAB. These are not only easy to understand but provide additional…

  7. The Utility of a Brief Experimental Analysis for Problem Behavior Maintained by Escape from Demands

    Science.gov (United States)

    Schmidt, Jonathan D.; Shanholtzer, Alison; Mezhoudi, Nabil; Scherbak, Bailey; Kahng, SungWoo

    2014-01-01

    Brief experimental analysis (BEA) is a useful tool for quickly evaluating intervention strategies for individuals with academic deficits and minor behavior problems. However, there is a lack of research investigating BEA for intervention strategies with individuals who emit severe problem behavior to avoid academic demands. For the current study,…

  8. Comparing Brief Experimental Analysis and Teacher Judgment for Selecting Early Reading Interventions

    Science.gov (United States)

    Wagner, Dana L.; Coolong-Chaffin, Melissa; Deris, Aaron R.

    2017-01-01

    The purpose of this study was to examine the use of brief experimental analysis (BEA) to identify early reading interventions for students in the primary grades and to compare teachers' judgments about their students' early reading intervention needs to BEA results. In addition, the research was conducted to explore how teachers make decisions…

  9. An experimental set-up for carbon isotopic analysis of atmospheric ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 122; Issue 3. An experimental set-up for carbon isotopic analysis of atmospheric CO2 and an example of ecosystem response during solar eclipse 2010. Tania Guha Prosenjit Ghosh. Volume 122 Issue 3 June 2013 pp 623-638 ...

  10. Structurally stitched woven preforms: experimental characterisation, geometrical modelling, and FE analysis

    NARCIS (Netherlands)

    Koysin, V.; Kustermans, J.; Lomov, S.V.; Verpoest, I.; Nakai, H.; Kurashiki, T.; Hamada, K.; Momoji, Y.; Zako, M.

    2009-01-01

    In this study, experimental data, geometrical models, and finite element analysis are presented for typical structurally stitched multilayer preform composed of quasi-unidirectional carbon fibre woven fabric. The term ‘structural’ presumes here that the stitching yarn does not only consolidate the

  11. Unsteady experimental and numerical analysis of a two-phase closed thermosyphon at different filling ratios

    NARCIS (Netherlands)

    Jafari, Davoud; Filippeschi, Sauro; Franco, Alessandro; Di Marco, Paolo

    2017-01-01

    This paper deals with the experimental analysis and numerical simulation of a two-phase closed thermosyphon (TPCT) in the aim to predict its transient performances. A concern in the design and operation of the TPCT is evaluating working fluid loading charge to maximize performance while avoiding

  12. The Impact of Probe Variability on Brief Experimental Analysis of Reading Skills

    Science.gov (United States)

    Mercer, Sterett H.; Harpole, Lauren Lestremau; Mitchell, Rachel R.; McLemore, Chandler; Hardy, Christina

    2012-01-01

    The purpose of this study was to examine the impact of probe variability on the ability to replicate results in brief experimental analysis (BEA) of reading. In the first phase of the study, 41 first- and second- grade students completed 16 oral reading fluency probes. Calculations of probe difficulty were used to identify Low and High Variability…

  13. "No Excuses" Charter Schools: A Meta-Analysis of the Experimental Evidence on Student Achievement

    Science.gov (United States)

    Cheng, Albert; Hitt, Collin; Kisida, Brian; Mills, Jonathan N.

    2017-01-01

    Many most well-known charter schools in the United States use a "No Excuses" approach. We conduct the first meta-analysis of the achievement impacts of No Excuses charter schools, focusing on experimental, lottery-based studies. We estimate that No Excuses charter schools increase student math and literacy achievement by 0.25 and 0.17,…

  14. Experimental bifurcation analysis of an impact oscillator - Tuning a non-invasive control scheme

    DEFF Research Database (Denmark)

    Bureau, Emil; Schilder, Frank; Santos, Ilmar

    2013-01-01

    We investigate a non-invasive, locally stabilizing control scheme necessary for an experimental bifurcation analysis. Our test-rig comprises a harmonically forced impact oscillator with hardening spring nonlinearity controlled by electromagnetic actuators, and serves as a prototype for electromag...

  15. Experimental approach to validation of an analytical and numerical thermal analysis of a travelling wave tube

    Science.gov (United States)

    Wiejak, W.; Wymysłowski, A.

    2016-01-01

    Travelling Wave Tube (TWT) is an electronic vacuum microwave device, which is used as a high power microwave amplifier, mainly in telecommunication purposes, e.g. radar systems. TWT's is an alternative solution in comparison to semiconductor devices in case of high power and high frequency applications. Thermal behaviour of TWT is one of the key aspects influencing its reliability and working parameters. The main goal of the research was to perform analytical, experimental and numerical analysis of a temperature distribution of a low band TWT in case of a typical working condition. Because the theoretical analysis seems to be very complex thus it was decided to compare the experimental results with the numerical simulations as well as with the simplified analytical formulas. As a first step of the presented research, the analytical analysis and numerical modelling of the helix TWT was carried out. The objective of the thermal analysis was to assess the temperature distribution in different parts of the helix TWT assembly during the extreme standard and working conditions. As a second stage of the research the numerical results were validated by the experimental measurements, which were carried out using a specially designed TWT test samples and corresponding experimental measurement tools.

  16. Tableau tool for testing satisfiability in LTL: Implementation and experimental analysis

    DEFF Research Database (Denmark)

    Goranko, Valentin; Kyrilov, Angelo; Shkatov, Dmitry

    2010-01-01

    We report on the implementation and experimental analysis of an incremental multi-pass tableau-based procedure `a la Wolper for testing satisfiability in the linear time temporal logic LTL, based on a breadthfirst search strategy. We describe the implementation and discuss the performance...

  17. Brief Experimental Analysis of Written Letter Formation: Single-Case Demonstration

    Science.gov (United States)

    Burns, Matthew K.; Ganuza, Zoila M.; London, Rachel M.

    2009-01-01

    Many students experience difficulty in acquiring basic writing skills and educators need to efficiently address those deficits by implementing an intervention with a high likelihood for success. The current article demonstrates the utility of using a brief experimental analysis (BEA) to identify a letter-formation intervention for a second-grade…

  18. Optimization and small-amplitude analysis of Purcell's three-link microswimmer model

    CERN Document Server

    Wiezel, Oren

    2016-01-01

    This work studies the motion of Purcell's three-link microswimmer in viscous flow, by using perturbation expansion of its dynamics under small-amplitude strokes. Leading-order expressions and next-order correction terms for the displacement of the swimmer are obtained for the cases of a square or circular gait in the plane of joint angles. The correction terms demonstrate the reversal in movement direction for large stroke amplitudes, which has previously only been shown numerically. In addition, asymptotic expressions for Lighthill's energetic efficiency are obtained for both gaits. These approximations enable calculating optimal stroke amplitudes and swimmer's geometry (i.e. ratio of links' lengths) for maximizing either the displacement or Lighthill's efficiency.

  19. Determinants for swine mycoplasmal pneumonia reproduction under experimental conditions: A systematic review and recursive partitioning analysis.

    Directory of Open Access Journals (Sweden)

    Beatriz Garcia-Morante

    Full Text Available One of the main Mycoplasma hyopneumoniae (M. hyopneumoniae swine experimental model objectives is to reproduce mycoplasmal pneumonia (MP. Unfortunately, experimental validated protocols to maximize the chance to successfully achieve lung lesions induced by M. hyopneumoniae are not available at the moment. Thus, the objective of this work was to identify those factors that might have a major influence on the effective development of MP, measured as macroscopic lung lesions, under experimental conditions. Data from 85 studies describing M. hyopneumoniae inoculation experiments were compiled by means of a systematic review and analyzed thereafter. Several variables were considered in the analyses such as the number of pigs in the experiment, serological status against M. hyopneumoniae, source of the animals, age at inoculation, type of inoculum, strain of M. hyopneumoniae, route, dose and times of inoculation, study duration and co-infection with other swine pathogens. Descriptive statistics were used to depict M. hyopneumoniae experimental model main characteristics whereas a recursive partitioning approach, using regression trees, assessed the importance of the abovementioned experimental variables as MP triggering factors. A strong link between the time period between challenge and necropsies and lung lesion severity was observed. Results indicated that the most important factors to explain the observed lung lesion score variability were: (1 study duration, (2 M. hyopneumoniae strain, (3 age at inoculation, (4 co-infection with other swine pathogens and (5 animal source. All other studied variables were not relevant to explain the variability on M. hyopneumoniae lung lesions. The results provided in the present work may serve as a basis for debate in the search for a universally accepted M. hyopneumoniae challenge model.

  20. Determinants for swine mycoplasmal pneumonia reproduction under experimental conditions: A systematic review and recursive partitioning analysis.

    Science.gov (United States)

    Garcia-Morante, Beatriz; Segalés, Joaquim; Serrano, Emmanuel; Sibila, Marina

    2017-01-01

    One of the main Mycoplasma hyopneumoniae (M. hyopneumoniae) swine experimental model objectives is to reproduce mycoplasmal pneumonia (MP). Unfortunately, experimental validated protocols to maximize the chance to successfully achieve lung lesions induced by M. hyopneumoniae are not available at the moment. Thus, the objective of this work was to identify those factors that might have a major influence on the effective development of MP, measured as macroscopic lung lesions, under experimental conditions. Data from 85 studies describing M. hyopneumoniae inoculation experiments were compiled by means of a systematic review and analyzed thereafter. Several variables were considered in the analyses such as the number of pigs in the experiment, serological status against M. hyopneumoniae, source of the animals, age at inoculation, type of inoculum, strain of M. hyopneumoniae, route, dose and times of inoculation, study duration and co-infection with other swine pathogens. Descriptive statistics were used to depict M. hyopneumoniae experimental model main characteristics whereas a recursive partitioning approach, using regression trees, assessed the importance of the abovementioned experimental variables as MP triggering factors. A strong link between the time period between challenge and necropsies and lung lesion severity was observed. Results indicated that the most important factors to explain the observed lung lesion score variability were: (1) study duration, (2) M. hyopneumoniae strain, (3) age at inoculation, (4) co-infection with other swine pathogens and (5) animal source. All other studied variables were not relevant to explain the variability on M. hyopneumoniae lung lesions. The results provided in the present work may serve as a basis for debate in the search for a universally accepted M. hyopneumoniae challenge model.

  1. A COMPARATIVE ANALYSIS BETWEEN UNIT-LINKED LIFE INSURANCE AND OTHER ALTERNATIVE INVESTMENTS

    Directory of Open Access Journals (Sweden)

    CRISTINA CIUMAS

    2015-07-01

    Full Text Available The unit-linked life insurance has two important components: protection and investment. The protection component refers to the insured sum in case of the occurrence of insured risks and the investment component refers to the policyholder’s account that represents the present value of the units from the chosen investment funds.These financial products invest most of the premium paid by the insured person in the funds managed by the insurance company or an external administrator and the lower part of the premium is intended to cover the insured risk (death, disability, etc. An important component of the activity carried out by the insurance companies is the investment of the premiums paid by policyholders in various types of assets, in order to obtain higher yields than those guaranteed by the insurance contracts, while providing the necessary liquidity for the payment of insurance claims in case of occurrence of the assumed risks. This research contributes to the existing literature regarding the study of investment alternatives, with an exclusive focus on the investment in unit-linked life insurance. A special place in this study is the presentation of investments in unit-linked insurance versus other types of financial investments: deposits, treasury bills, shares (BET, currency (EURO and gold.

  2. [A Method for Protein Photo-cross-linking in Living Cells Facilitating Analysis of Physiological Interactions of Proteins].

    Science.gov (United States)

    Hino, Nobumasa

    2015-01-01

    In living cells, most proteins form complexes with other proteins to exert their functions. Since protein functions are regulated in response to changes in the cellular environment, the components of the complexes can vary; therefore, proteins often interact in a weak and transient manner. To capture such labile protein interactions, we have developed a method for photo-cross-linking of proteins directly interacting in mammalian cells; this method involves expansion of the genetic code and site-specific incorporation of photoreactive amino acids into proteins. Upon cross-linking, protein complexes are stabilized by a covalent bond and can be readily isolated from cell extracts without the problems usually associated with simple affinity purification methods such as co-immunoprecipitation. Photo-cross-linkers have another benefit: they react exclusively with molecules within a range defined by the linker length. This property becomes useful for determining the binding interface of two proteins because the linkers can be introduced in a site-directed manner with our method. In this review, we first describe the expansion of the genetic code of mammalian cells for the incorporation of non-natural amino acids into proteins. Then, we introduce our recent applications and developments of the cross-linking method: identification of intracellular binding partners of the signaling protein growth factor receptor binding protein 2; analysis of the binding between membrane proteins on the cell surface; and a novel photoreactive amino acid that enables wide-ranging photo-cross-linking.

  3. Advancements in mass spectrometry for biological samples: Protein chemical cross-linking and metabolite analysis of plant tissues

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Adam [Iowa State Univ., Ames, IA (United States)

    2015-01-01

    This thesis presents work on advancements and applications of methodology for the analysis of biological samples using mass spectrometry. Included in this work are improvements to chemical cross-linking mass spectrometry (CXMS) for the study of protein structures and mass spectrometry imaging and quantitative analysis to study plant metabolites. Applications include using matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to further explore metabolic heterogeneity in plant tissues and chemical interactions at the interface between plants and pests. Additional work was focused on developing liquid chromatography-mass spectrometry (LC-MS) methods to investigate metabolites associated with plant-pest interactions.

  4. Experimental measurement and numerical analysis on resonant characteristics of piezoelectric disks with partial electrode designs.

    Science.gov (United States)

    Lin, Yu-Chih; Ma, Chien-Ching

    2004-08-01

    Three experimental techniques are used in this study to access the influence of the electrode arrangement on the resonant characteristics of piezoceramic disks. These methods, including the amplitude-fluctuation electronic speckle pattern interferometry (AF-ESPI), laser Doppler vibrometer-dynamic signal analyzer (LDV-DSA), and impedance analysis, are based on the measurement of full-field displacement, pointwise displacement, and electric impedance, respectively. In this study, one full electrode design and three nonsymmetrical partial electrode designs of piezoelectric disks are investigated. Because the clear fringe patterns measured by the AF-ESPI method will be shown only at resonant frequencies, both the resonant frequencies and the corresponding vibration mode shapes are successfully obtained at the same time for out-of-plane and in-plane motions. The second experimental method is the impedance analysis, which is used to measure the resonant and antiresonant frequencies. In addition to these experimental methods, LDV-DSA is used to determine the resonant frequencies of the vibration mode with out-of-plane motion. From the experimental results, the dependence of electrode design on the vibration frequencies and mode shapes is addressed. Numerical computations based on the finite element method are presented, and the results are compared with the experimental measurements. The effect of different designs of electrode is more significant in the in-plane modes than that in the out-of-plane modes.

  5. Stereochemical analysis of menthol and menthylamine isomers using calculated and experimental optical rotation data

    Science.gov (United States)

    Reinscheid, F.; Reinscheid, U. M.

    2016-01-01

    The complete series of menthol isomers and their corresponding amino derivatives (base and protonated/HCl forms), were investigated using experimental and theoretical data. Our study focused on the conformational and configurational analysis, and revealed that experimental data should be used in combination with calculated data. Furthermore, even in the case of the highly studied member, menthol, discrepancies were found among previously published literature values. We show that the correct determination of the population mix is a must for the correct prediction of the absolute configuration (AC) of neoisomenthol. The neoiso forms are of special interest since a number of structural inconsistences can be found in the literature. We present a stringent proof of the AC of neoisomenthol based on literature information. To the best of our knowledge, the AC of neoisomenthylamine is for the first time shown using experimental and calculated optical rotation data. A correction of a series of publications containing an important error in the assignment of (+)-menthylamine (correct: (+)-neomenthylamine) is presented. With 26 data pairs (experimental versus calculated) of optical rotation values a regression is performed. The AC of all 12 compounds, even the most difficult neoiso forms, could be predicted correctly using experimental low-temperature NMR data. Furthermore, if only experimental data with an optical rotation outside the range of -10 +10 are used, all 12 compounds would have been correctly assigned without low-temperature NMR data as restraints.

  6. Experimental design and analysis for accelerated degradation tests with Li-ion cells.

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, Daniel Harvey; Thomas, Edward Victor; Jungst, Rudolph George; Roth, Emanuel Peter

    2003-08-01

    This document describes a general protocol (involving both experimental and data analytic aspects) that is designed to be a roadmap for rapidly obtaining a useful assessment of the average lifetime (at some specified use conditions) that might be expected from cells of a particular design. The proposed experimental protocol involves a series of accelerated degradation experiments. Through the acquisition of degradation data over time specified by the experimental protocol, an unambiguous assessment of the effects of accelerating factors (e.g., temperature and state of charge) on various measures of the health of a cell (e.g., power fade and capacity fade) will result. In order to assess cell lifetime, it is necessary to develop a model that accurately predicts degradation over a range of the experimental factors. In general, it is difficult to specify an appropriate model form without some preliminary analysis of the data. Nevertheless, assuming that the aging phenomenon relates to a chemical reaction with simple first-order rate kinetics, a data analysis protocol is also provided to construct a useful model that relates performance degradation to the levels of the accelerating factors. This model can then be used to make an accurate assessment of the average cell lifetime. The proposed experimental and data analysis protocols are illustrated with a case study involving the effects of accelerated aging on the power output from Gen-2 cells. For this case study, inadequacies of the simple first-order kinetics model were observed. However, a more complex model allowing for the effects of two concurrent mechanisms provided an accurate representation of the experimental data.

  7. Collagen cross-linking using riboflavin and ultraviolet-a for corneal thinning disorders: an evidence-based analysis.

    Science.gov (United States)

    Pron, G; Ieraci, L; Kaulback, K

    2011-01-01

    The main objectives for this evidence-based analysis were to determine the safety and effectiveness of photochemical corneal collagen cross-linking with riboflavin (vitamin B(2)) and ultraviolet-A radiation, referred to as CXL, for the management of corneal thinning disease conditions. The comparative safety and effectiveness of corneal cross-linking with other minimally invasive treatments such as intrastromal corneal rings was also reviewed. The Medical Advisory Secretariat (MAS) evidence-based analysis was performed to support public financing decisions. SUBJECT OF THE EVIDENCE-BASED ANALYSIS: The primary treatment objective for corneal cross-linking is to increase the strength of the corneal stroma, thereby stabilizing the underlying disease process. At the present time, it is the only procedure that treats the underlying disease condition. The proposed advantages for corneal cross-linking are that the procedure is minimally invasive, safe and effective, and it can potentially delay or defer the need for a corneal transplant. In addition, corneal cross-linking does not adversely affect subsequent surgical approaches, if they are necessary, or interfere with corneal transplants. The evidence for these claims for corneal cross-linking in the management of corneal thinning disorders such as keratoconus will be the focus of this review. The specific research questions for the evidence review were as follows: TECHNICAL: How technically demanding is corneal cross-linking and what are the operative risks? What is known about the broader safety profile of corneal cross-linking?Effectiveness - Corneal Surface Topographic Affects:What are the corneal surface remodeling effects of corneal cross-linking?Do these changes interfere with subsequent interventions, particularly corneal transplant known as penetrating keratoplasty (PKP)?Effectiveness -Visual Acuity:What impacts does the remodeling have on visual acuity?Are these impacts predictable, stable, adjustable and

  8. Experimental investigation and performance analysis of inertia properties measurement for heavy truck cab

    Directory of Open Access Journals (Sweden)

    Tianjun Zhu

    2015-11-01

    Full Text Available An experimental investigation and performance analysis of inertia properties measurement for heavy truck cab is presented. This method is specifically intended for measuring the inertia properties of irregular rigid bodies, and it has the potential to be applied to the measurement of the inertia properties of vehicle bodies, such as the cab, engine, and gearbox. This article, based on CATARC moment of inertia measurement system test rig, develops an accurate measuring method to identify inertia parameters of heavy truck cab. First, corresponding tests are carried out, and the lever principle and moments of inertia parallel theorem are employed to calculate and analyse the test results, which leads to the accurate value of inertia parameters. Second, the performance analysis of the proposed method is verified through the measurement error analysis. As a result, the proposed method shows high accuracy, which provides an experimental basis for accurate inertia parameter measurement of heavy truck cab.

  9. Development of a thermal-hydraulic code for reflood analysis in a PWR experimental loop

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Sabrina P.; Mesquita, Amir Z.; Rezende, Hugo C., E-mail: sabrinapral@gmail.com, E-mail: amir@cdtn.brm, E-mail: hcr@cdtn.br, E-mail: hcr@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Palma, Daniel A.P., E-mail: dapalma@cnen.gov.br [Comissão Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    A process of fundamental importance in the event of Loss of Coolant Accident (LOCA) in Pressurized Water nuclear Reactors (PWR) is the reflood of the core or rewetting of nuclear fuels. The Nuclear Technology Development Center (CDTN) has been developing since the 70’s programs to allow Brazil to become independent in the field of reactor safety analysis. To that end, in the 80’s was designed, assembled and commissioned one Rewetting Test Facility (ITR in Portuguese). This facility aims to investigate the phenomena involved in the thermal hydraulic reflood phase of a Loss of Coolant Accident in a PWR nuclear reactor. This work aim is the analysis of physical and mathematical models governing the rewetting phenomenon, and the development a thermo-hydraulic simulation code of a representative experimental circuit of the PWR reactors core cooling channels. It was possible to elaborate and develop a code called REWET. The results obtained with REWET were compared with the experimental results of the ITR, and with the results of the Hydroflut code, that was the old program previously used. An analysis was made of the evolution of the wall temperature of the test section as well as the evolution of the front for two typical tests using the two codes calculation, and experimental results. The result simulated by REWET code for the rewetting time also came closer to the experimental results more than those calculated by Hydroflut code. (author)

  10. Linear quadratic Gaussian control for adaptive optics and multiconjugate adaptive optics: experimental and numerical analysis.

    Science.gov (United States)

    Petit, Cyril; Conan, Jean-Marc; Kulcsár, Caroline; Raynaud, Henri-François

    2009-06-01

    We present a comprehensive analysis of the linear quadratic Gaussian control approach applied to adaptive optics (AO) and multiconjugated AO (MCAO) based on numerical and experimental validations. The structure of the control law is presented and its main properties discussed. We then propose an extended experimental validation of this control law in AO and a simplified MCAO configuration. Performance is compared with end-to-end numerical simulations. Sensitivity of the performance regarding tuning parameters is tested. Finally, extension to full MCAO and laser tomographic AO (LTAO) through numerical simulation is presented and analyzed.

  11. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    DEFF Research Database (Denmark)

    Luczak, Marcin; Manzato, Simone; Peeters, Bart

    2014-01-01

    is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations...... were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set...

  12. Theoretical analysis and experimental verification of parabolic trough solar collector with hot water generation system

    Directory of Open Access Journals (Sweden)

    Valan-Arasu Amirtham

    2007-01-01

    Full Text Available The modeling of a parabolic trough collector with hot water generation system with a well-mixed type storage tank using a computer simulation program is presented in this paper. This is followed by an experimental verification of the model and an analysis of the experimental results. The maximum difference between the predicted and the actual storage tank water temperature values is found as 9.59% only. This variation is due to the difference between the actual weather during the test period compared to hourly values and the convection losses from the collector receiver, which were not constant as accounted by the computer simulation program. .

  13. Hydrodynamics of back spatter by blunt bullet gunshot with a link to bloodstain pattern analysis

    Science.gov (United States)

    Comiskey, P. M.; Yarin, A. L.; Attinger, D.

    2017-07-01

    A theoretical model describing the blood spatter pattern resulting from a blunt bullet gunshot is proposed. The predictions are compared to experimental data acquired in the present work. This hydrodynamic problem belongs to the class of the impact hydrodynamics with the pressure impulse generating the blood flow. At the free surface, the latter is directed outwards and accelerated toward the surrounding air. As a result, the Rayleigh-Taylor instability of the flow of blood occurs, which is responsible for the formation of blood drops of different sizes and initial velocities. Thus, the initial diameter, velocity, and acceleration of the atomized blood drops can be determined. Then, the equations of motion are solved, describing drop trajectories in air accounting for gravity, and air drag. Also considered are the drop-drop interactions through air, which diminish air drag on the subsequent drops. Accordingly, deposition of two-phase (blood-drop and air) jets on a vertical cardstock sheet located between the shooter and the target (and perforated by the bullet) is predicted and compared with experimental data. The experimental data were acquired with a porous polyurethane foam sheet target impregnated with swine blood, and the blood drops were collected on a vertical cardstock sheet which was perforated by the blunt bullet. The highly porous target possesses a low hydraulic resistance and therefore resembles a pool of blood shot by a blunt bullet normally to its free surface. The back spatter pattern was predicted numerically and compared to the experimental data for the number of drops, their area, the total stain area, and the final impact angle as functions of radial location from the bullet hole in the cardstock sheet (the collection screen). Comparisons of the predicted results with the experimental data revealed satisfactory agreement. The predictions also allow one to find the impact Weber number on the collection screen, which is necessary to predict stain

  14. Crucial role of detailed function, task, timeline, link and human vulnerability analyses in HRA. [Human Reliability Analysis (HRA)

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, T.G.; Haney, L.N.; Ostrom, L.T.

    1992-01-01

    This paper addresses one major cause for large uncertainties in human reliability analysis (HRA) results, that is, an absence of detailed function, task, timeline, link and human vulnerability analyses. All too often this crucial step in the HRA process is done in a cursory fashion using word of mouth or written procedures which themselves may incompletely or inaccurately represent the human action sequences and human error vulnerabilities being analyzed. The paper examines the potential contributions these detailed analyses can make in achieving quantitative and qualitative HRA results which are: (1) creditable, that is, minimize uncertainty, (2) auditable, that is, systematically linking quantitative results and qualitative information from which the results are derived, (3) capable of supporting root cause analyses on human reliability factors determined to be major contributors to risk, and (4) capable of repeated measures and being combined with similar results from other analyses to examine HRA issues transcending individual systems and facilities. Based on experience analyzing test and commercial nuclear reactors, and medical applications of nuclear technology, an iterative process is suggested for doing detailed function, task, timeline, link and human vulnerability analyses using documentation reviews, open-ended and structured interviews, direct observations, and group techniques. Finally, the paper concludes that detailed analyses done in this manner by knowledgeable human factors practitioners, can contribute significantly to the credibility, auditability, causal factor analysis, and combining goals of the HRA.

  15. Analysis of Three-Phase Rectifier Systems with Controlled DC-Link Current Under Unbalanced Grids

    DEFF Research Database (Denmark)

    Kumar, Dinesh; Davari, Pooya; Zare, Firuz

    2017-01-01

    Voltage unbalance is the most common disturbance in distribution networks, which give undesirable effects on many grid connected power electronics systems including Adjustable Speed Drive (ASD). Severe voltage unbalance can force three-phase rectifiers into almost single-phase operation, which...... degrades the grid power quality and also imposes a significant negative impact on the ASD system. This major power quality issue affecting the conventional rectifiers can be attenuated by controlling the DC-link current based on an Electronic Inductor (EI) technique. The purpose of this digest...

  16. Single-molecule analysis of DNA cross-links using nanopore technology

    Science.gov (United States)

    Wolna, Anna H.

    The alpha-hemolysin (alpha-HL) protein ion channel is a potential next-generation sequencing platform that has been extensively used to study nucleic acids at a single-molecule level. After applying a potential across a lipid bilayer, the imbedded alpha-HL allows monitoring of the duration and current levels of DNA translocation and immobilization. Because this method does not require DNA amplification prior to sequencing, all the DNA damage present in the cell at any given time will be present during the sequencing experiment. The goal of this research is to determine if these damage sites give distinguishable current levels beyond those observed for the canonical nucleobases. Because DNA cross-links are one of the most prevalent types of DNA damage occurring in vivo, the blockage current levels were determined for thymine-dimers, guanine(C8)-thymine(N3) cross-links and platinum adducts. All of these cross-links give a different blockage current level compared to the undamaged strands when immobilized in the ion channel, and they all can easily translocate across the alpha-HL channel. Additionally, the alpha-HL nanopore technique presents a unique opportunity to study the effects of DNA cross-links, such as thymine-dimers, on the secondary structure of DNA G-quadruplexes folded from the human telomere sequence. Using this single-molecule nanopore technique we can detect subtle structural differences that cannot be easily addressed using conventional methods. The human telomere plays crucial roles in maintaining genome stability. In the presence of suitable cations, the repetitive 5'-TTAGGG human telomere sequence can fold into G-quadruplexes that adopt the hybrid fold in vivo. The telomere sequence is hypersensitive to UV-induced thymine-dimer (T=T) formation, and yet the presence of thymine dimers does not cause telomere shortening. The potential structural disruption and thermodynamic stability of the T=T-containing natural telomere sequences were studied to

  17. Experimental design for the formulation and optimization of novel cross-linked oilispheres developed for in vitro site-specific release of Mentha piperita oil.

    Science.gov (United States)

    Sibanda, Wilbert; Pillay, Viness; Danckwerts, Michael P; Viljoen, Alvaro M; van Vuuren, Sandy; Khan, Riaz A

    2004-03-12

    A Plackett-Burman design was employed to develop and optimize a novel crosslinked calcium-aluminum-alginate-pectinate oilisphere complex as a potential system for the in vitro site-specific release of Mentha piperita, an essential oil used for the treatment of irritable bowel syndrome. The physicochemical and textural properties (dependent variables) of this complex were found to be highly sensitive to changes in the concentration of the polymers (0%-1.5% wt/vol), crosslinkers (0%-4% wt/vol), and crosslinking reaction times (0.5-6 hours) (independent variables). Particle size analysis indicated both unimodal and bimodal populations with the highest frequency of 2 mm oilispheres. Oil encapsulation ranged from 6 to 35 mg/100 mg oilispheres. Gravimetric changes of the crosslinked matrix indicated significant ion sequestration and loss in an exponential manner, while matrix erosion followed Higuchi's cube root law. Among the various measured responses, the total fracture energy was the most suitable optimization objective (R2 = 0.88, Durbin-Watson Index = 1.21%, Coefficient of Variation (CV) = 33.21%). The Lagrangian technique produced no significant differences (P > .05) between the experimental and predicted total fracture energy values (0.0150 vs 0.0107 J). Artificial Neural Networks, as an alternative predictive tool of the total fracture energy, was highly accurate (final mean square error of optimal network epoch approximately 0.02). Fused-coated optimized oilispheres produced a 4-hour lag phase followed by zero-order kinetics (n > 0.99), whereby analysis of release data indicated that diffusion (Fickian constant k1 = 0.74 vs relaxation constant k2 = 0.02) was the predominant release mechanism.

  18. Modeling and Link Performance Analysis of Busbar Distribution Systems for Narrowband PLC

    Directory of Open Access Journals (Sweden)

    Z. Hasirci

    2017-06-01

    Full Text Available Busbar distribution system is used as a modular infrastructure to carry electrical energy in low voltage grid. Due to the widespread usage in industrial areas, the power line communication possibilities should be investigated in terms of smart grid concept. This paper addresses modeling of the busbar distribution system as a transmission line and gives some suggestions on the link performance for narrowband power line communication for the first time in literature. Firstly, S-parameters of different current level busbars were measured up to 500 kHz for all possible two-port signal paths. The utilization of the frequency-dependent model was proposed to extract transmission line characteristics to eliminate the unwanted measurement effects. Particle swarm algorithm was used to optimize the model parameters with a good agreement between measured and simulated S-parameters. Additionally, link performance of busbar distribution system as a power line communication channel at 3 kHz-148.5 kHz band was examined for frequency shift keying and phase shift keying modulations under different network configurations such as varying busbar type, the line length between transmitter and receiver, branch number, and terminating load impedance. Obtained results were presented as bit-error-rate vs. signal to noise ratio graphs.

  19. N-Linked Glycosylation in Archaea: a Structural, Functional, and Genetic Analysis

    Science.gov (United States)

    Ding, Yan; Meyer, Benjamin H.; Albers, Sonja-Verena; Kaminski, Lina; Eichler, Jerry

    2014-01-01

    SUMMARY N-glycosylation of proteins is one of the most prevalent posttranslational modifications in nature. Accordingly, a pathway with shared commonalities is found in all three domains of life. While excellent model systems have been developed for studying N-glycosylation in both Eukarya and Bacteria, an understanding of this process in Archaea was hampered until recently by a lack of effective molecular tools. However, within the last decade, impressive advances in the study of the archaeal version of this important pathway have been made for halophiles, methanogens, and thermoacidophiles, combining glycan structural information obtained by mass spectrometry with bioinformatic, genetic, biochemical, and enzymatic data. These studies reveal both features shared with the eukaryal and bacterial domains and novel archaeon-specific aspects. Unique features of N-glycosylation in Archaea include the presence of unusual dolichol lipid carriers, the use of a variety of linking sugars that connect the glycan to proteins, the presence of novel sugars as glycan constituents, the presence of two very different N-linked glycans attached to the same protein, and the ability to vary the N-glycan composition under different growth conditions. These advances are the focus of this review, with an emphasis on N-glycosylation pathways in Haloferax, Methanococcus, and Sulfolobus. PMID:24847024

  20. Analysis of ligand-receptor cross-linked fragments by mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Son, C.D. [University of Tennessee, Knoxville (UTK); Sargsyan, H. [City University of New York (CUNY); Hurst, Gregory {Greg} B [ORNL; Naider, F. [City University of New York (CUNY); Becker, J.M. [University of Tennessee, Knoxville (UTK)

    2005-01-01

    G-protein coupled receptors (GPCRs) are a class of integral membrane receptor proteins that are characterized by a signature seven-transmembrane (7-TM) configuration. The a-factor receptor (Ste2p) from Saccharomyces cerevisiae is a GPCR that, upon binding of a peptide ligand, transduces a signal to initiate a cascade of events leading to the mating of haploid yeast cells. This study summarizes the application of affinity purification and of matrix-assisted laser-desorption ionization time-of-flight (MALDI-TOF) experiments using biotinylated photoactivatable a-factor analogs. Affinity purification and enrichment of biotinylated peptides by monomeric avidin beads resulted in mass spectrometric detection of specific signals corresponding to crosslinked fragments of Ste2p. Data obtained from cyanogen bromide (CNBr) fragments of receptor cross-linked to an a-factor analog with the photoaffinity group p-benzoyl-L-phenylalanine on position 1 were in agreement with the previous results reported by our laboratory suggesting the cross-linking between position 1 of a-factor and a region of Ste2p covering residues 251 294.

  1. Removal of Cr(III ions from salt solution by nanofiltration: experimental and modelling analysis

    Directory of Open Access Journals (Sweden)

    Kowalik-Klimczak Anna

    2016-09-01

    Full Text Available The aim of this study was experimental and modelling analysis of the nanofiltration process used for the removal of chromium(III ions from salt solution characterized by low pH. The experimental results were interpreted with Donnan and Steric Partitioning Pore (DSP model based on the extended Nernst-Planck equation. In this model, one of the main parameters, describing retention of ions by the membrane, is pore dielectric constant. In this work, it was identified for various process pressures and feed compositions. The obtained results showed the satisfactory agreement between the experimental and modelling data. It means that the DSP model may be helpful for the monitoring of nanofiltration process applied for treatment of chromium tannery wastewater.

  2. Laser-assisted bending of Titanium Grade-2 sheets: Experimental analysis and numerical simulation

    Science.gov (United States)

    Gisario, Annamaria; Mehrpouya, Mehrshad; Venettacci, Simone; Barletta, Massimiliano

    2017-05-01

    External force laser-assisted bending of Titanium Grade-2 flat sheets to achieve sharp bending angles (>140°) with small fillet radii is herein investigated. In particular, the influence of the operational parameters, laser power, scan speed, number of passes, on bending angles and fillet radii of the metal substrates is analysed. The experimental results show that shaping of the substrates can be performed with great reliability, being springback largely minimised in broad operational ranges. Exploratory Data Analysis (EDA) allows the design of first approximation technological models and, in turn, the development of 3d processing maps. Based on the experimental findings, numerical modelling of the bending process by the Finite Element Method (FEM) through ABAQUS/Explicit software is also developed. The numerical model is found to match with great accuracy the experimental results, being it also extremely flexible and responsive to the change of the operational parameters.

  3. Analysis of HR consultants and French recruiters activity on LinkedIn. In between work resource and quest of identity development

    Directory of Open Access Journals (Sweden)

    Hélène HOBLINGRE

    2016-12-01

    Full Text Available This article investigates usage of LinkedIn by HR professionals. Based on twelve HR consultants and recruiters interviews, LinkedIn usage analysis highlights that this tool is used in a mix of private and professional practices. It sheds a light on the tension of using LinkedIn as a business tool versus LinkedIn as a tool to develop personal projects. Using LinkedIn in a professional context implies following norms and guidelines that impact user freedom. As a consequence, this prevents user from benefiting from all LinkedIn developmental capabilities. Eventually, our results stress the need for an individual to use LinkedIn as a reflective practitioner. This should be done in the light of building purpose to professional activities and accommodating functional usage with strategic practices.

  4. Compression algorithm for data analysis in a radio link (preparation of PACEM 2 experiment)

    Science.gov (United States)

    Leroux, G.; Sylvain, M.

    1982-11-01

    The Hadamard transformation for image compression is applied to a radio data transmission system. The programs used and the performance obtained are described. The algorithms use PASCAL and the listed programs are written in FORTRAN 77. The experimental results of 62 images of 64 lines, show a standard deviation of 1.5% with a compression rate of 18.5, which is in accordance with the proposed goals.

  5. An innovative experimental sequence on electromagnetic induction and eddy currents based on video analysis and cheap data acquisition

    Science.gov (United States)

    Bonanno, A.; Bozzo, G.; Sapia, P.

    2017-11-01

    In this work, we present a coherent sequence of experiments on electromagnetic (EM) induction and eddy currents, appropriate for university undergraduate students, based on a magnet falling through a drilled aluminum disk. The sequence, leveraging on the didactical interplay between the EM and mechanical aspects of the experiments, allows us to exploit the students’ awareness of mechanics to elicit their comprehension of EM phenomena. The proposed experiments feature two kinds of measurements: (i) kinematic measurements (performed by means of high-speed video analysis) give information on the system’s kinematics and, via appropriate numerical data processing, allow us to get dynamic information, in particular on energy dissipation; (ii) induced electromagnetic field (EMF) measurements (by using a homemade multi-coil sensor connected to a cheap data acquisition system) allow us to quantitatively determine the inductive effects of the moving magnet on its neighborhood. The comparison between experimental results and the predictions from an appropriate theoretical model (of the dissipative coupling between the moving magnet and the conducting disk) offers many educational hints on relevant topics related to EM induction, such as Maxwell’s displacement current, magnetic field flux variation, and the conceptual link between induced EMF and induced currents. Moreover, the didactical activity gives students the opportunity to be trained in video analysis, data acquisition and numerical data processing.

  6. The link in Linking

    Science.gov (United States)

    Caldwell, Jane C; Chiale, Pablo A; Gonzalez, Mario D; Baranchuk, Adrian

    2013-01-01

    We present 2 cases of the slow-fast form of AVNRT with initially narrow QRS complexes followed by sudden unexpected transition to persistently wide QRS complexes due to aberrant intraventricular conduction. Introduction of a properly timed extrastimulus in one case and critical oscillations in cycle length due to short-long coupling in the second case set the stage for the initial bundle branch block. However, persistence of the aberrancy pattern once the initial event abated was maintained by the "linking" phenomenon. Delayed, retrograde concealed activation from the contralateral bundle branch perpetuated the initial bundle branch block. PMID:23840106

  7. The emergence of modern statistics in agricultural science: analysis of variance, experimental design and the reshaping of research at Rothamsted Experimental Station, 1919-1933.

    Science.gov (United States)

    Parolini, Giuditta

    2015-01-01

    During the twentieth century statistical methods have transformed research in the experimental and social sciences. Qualitative evidence has largely been replaced by quantitative results and the tools of statistical inference have helped foster a new ideal of objectivity in scientific knowledge. The paper will investigate this transformation by considering the genesis of analysis of variance and experimental design, statistical methods nowadays taught in every elementary course of statistics for the experimental and social sciences. These methods were developed by the mathematician and geneticist R. A. Fisher during the 1920s, while he was working at Rothamsted Experimental Station, where agricultural research was in turn reshaped by Fisher's methods. Analysis of variance and experimental design required new practices and instruments in field and laboratory research, and imposed a redistribution of expertise among statisticians, experimental scientists and the farm staff. On the other hand the use of statistical methods in agricultural science called for a systematization of information management and made computing an activity integral to the experimental research done at Rothamsted, permanently integrating the statisticians' tools and expertise into the station research programme. Fisher's statistical methods did not remain confined within agricultural research and by the end of the 1950s they had come to stay in psychology, sociology, education, chemistry, medicine, engineering, economics, quality control, just to mention a few of the disciplines which adopted them.

  8. Experimental and Theoretical Analysis of Storage Friendly TCP Performance in Distributed Storage Area Network

    Directory of Open Access Journals (Sweden)

    Suresh Muknahallipatna

    2007-08-01

    Full Text Available Fibre channel storage area networks (SAN are widely implemented in production data center environments. Recently the storage industry has moved towards deployment of distributed SANs (DSAN, geographically dispersed across large physical distances. In a DSAN, specialized gateway devices interconnect the individual Fibre Channel (FC fabrics over IP networks using TCP/IP based protocols (iFCP or FCIP or over metro to long distance optical networks such as Dense Wavelength Division Multiplexing (DWDM based networks that utilize native FC ports supporting large numbers of link credits. When using TCP/IP based storage networking protocols to interconnect local FC fabrics in a DSAN, the sustained throughput achievable depends upon the link characteristics and TCP/IP stack implementation. Sustaining maximum possible storage traffic throughput across the wide area network enables practical DSAN deployments by maintaining the required site to site service level agreements.This study explores the effects of several TCP/IP modifications on sustained traffic throughput for a DSAN interconnected via iFCP gateways across an impaired network. The TCP/IP stack modifications, known as storage friendly, include changes to the window scaling, congestion avoidance, and fast recovery algorithms. The theoretical background and experimental results are presented to explain and illustrate these modifications.

  9. Analytical and experimental analysis of solute transport in heterogeneous porous media.

    Science.gov (United States)

    Wu, Lei; Gao, Bin; Tian, Yuan; Muñoz-Carpena, Rafael

    2014-01-01

    Knowledge of solute transport in heterogeneous porous media is crucial to monitor contaminant fate and transport in soil and groundwater systems. In this study, we present new findings from experimental and mathematical analysis to improve current understanding of solute transport in structured heterogeneous porous media. Three saturated columns packed with different sand combinations were used to examine the breakthrough behavior of bromide, a conservative tracer. Experimental results showed that bromide had different breakthrough responses in the three types of sand combinations, indicating that heterogeneity in hydraulic conductivity has a significant effect on the solute transport in structured heterogeneous porous media. Simulations from analytical solutions of a two-domain solute transport model matched experimental breakthrough data well for all the experimental conditions tested. Experimental and model results show that under saturated flow conditions, advection dominates solute transport in both fast-flow and slow-flow domains. The sand with larger hydraulic conductivity provided a preferential flow path for solute transport (fast-flow domain) that dominates the mass transfer in the heterogeneous porous media. Importantly, the transport in the slow-flow domain and mass exchange between the domains also contribute to the flow and solute transport processes and thus must be considered when investigating contaminant transport in heterogeneous porous media.

  10. Wound ballistics of the pig mandibular angle: a preliminary finite element analysis and experimental study.

    Science.gov (United States)

    Chen, Yubin; Miao, Yingyun; Xu, Chuan; Zhang, Gang; Lei, Tao; Tan, Yinghui

    2010-04-19

    To study wound ballistics of the mandibular angle, a combined hexahedral-tetrahedral finite element (FE) model of the pig mandible was developed to simulate ballistic impact. An experimental study was carried out by measuring impact load parameters from 14 fresh pig mandibles that were shot at the mandibular angle by a standard 7.62 mm M43 bullet. FE analysis was executed through the LS-DYNA code under impact loads similar to those obtained from the experimental study. The resulting residual velocity, the transferred energy from the bullet to the mandible, and the surface area of the entrance wound had no statistical differences between the FE simulation and the experimental study. However, the mean surface area of the exit wounds in the experimental study was significantly larger than that in the simulation. According to the FE analysis, the stress concentrated zones were mainly located at the region of impact, condylar neck, coronoid process and mandibular body. The simulation results also indicated that trabecular bone had less stress concentration and a lower speed of stress propagation compared with cortical bone. The FE model is appropriate and conforms to the basic principles of wound ballistics. This modeling system will be helpful for further investigations of the biomechanical mechanisms of wound ballistics. Copyright 2009 Elsevier Ltd. All rights reserved.

  11. Experimental and theoretical analysis of a hybrid solar thermoelectric generator with forced convection cooling

    Science.gov (United States)

    Sundarraj, Pradeepkumar; Taylor, Robert A.; Banerjee, Debosmita; Maity, Dipak; Sinha Roy, Susanta

    2017-01-01

    Hybrid solar thermoelectric generators (HSTEGs) have garnered significant research attention recently due to their potential ability to cogenerate heat and electricity. In this paper, theoretical and experimental investigations of the electrical and thermal performance of a HSTEG system are reported. In order to validate the theoretical model, a laboratory scale HSTEG system (based on forced convection cooling) is developed. The HSTEG consists of six thermoelectric generator modules, an electrical heater, and a stainless steel cooling block. Our experimental analysis shows that the HSTEG is capable of producing a maximum electrical power output of 4.7 W, an electrical efficiency of 1.2% and thermal efficiency of 61% for an average temperature difference of 92 °C across the TEG modules with a heater power input of 382 W. These experimental results of the HSTEG system are found to be in good agreement with the theoretical prediction. This experimental/theoretical analysis can also serve as a guide for evaluating the performance of the HSTEG system with forced convection cooling.

  12. Improvement or selection? A longitudinal analysis of students' views about experimental physics in their lab courses

    Science.gov (United States)

    Wilcox, Bethany R.; Lewandowski, H. J.

    2017-12-01

    Laboratory courses represent a unique and potentially important component of the undergraduate physics curriculum, which can be designed to allow students to authentically engage with the process of experimental physics. Among other possible benefits, participation in these courses throughout the undergraduate physics curriculum presents an opportunity to develop students' understanding of the nature and importance of experimental physics within the discipline as a whole. Here, we present and compare both a longitudinal and pseudolongitudinal analysis of students' responses to a research-based assessment targeting students' views about experimental physics—the Colorado Learning Attitudes about Science Survey for Experimental Physics (E-CLASS)—across multiple, required lab courses at a single institution. We find that, while pseudolongitudinal averages showed increases in students' E-CLASS scores in each consecutive course, analysis of longitudinal data indicates that this increase was not driven by a cumulative impact of laboratory instruction. Rather, the increase was driven by a selection effect in which students who persisted into higher-level lab courses already had more expertlike beliefs, attitudes, and expectations than their peers when they started the lower-level courses.

  13. Teleoperation of an experimental mobile vehicle via a free-space optical laser line-of-sight communication link for use in nuclear power plant environments

    Science.gov (United States)

    Girach, Khalid; Bouazza-Marouf, K.; Kerr, David; Hewit, Jim

    1994-11-01

    The paper describes the investigations carried out to implement a line of sight control and communication link for a mobile robot vehicle for use in structured nuclear semi-hazardous environments. Line of sight free space optical laser communication links for remote teleoperation have important applications in hazardous environments. They have certain advantages over radio/microwave links and umbilical control such as greater protection against generation of and susceptance to electro-magnetic fields. The cable-less environment provides increased integrity and mechanical freedom to the mobile robot. However, to maintain the communication link, continuous point and tracking is required between the base station and the mobile vehicle. This paper presents a novel two ended optical tracking system utilizing the communication laser beams and photodetectors. The mobile robot is a six wheel drive vehicle with a manipulator arm which can operate in a variety of terrain. The operator obtains visual feedback information from cameras placed on the vehicle. From this information, the speed and direction of the vehicle can be controlled from a joystick panel. We describe the investigations carried out for the communication of analogue video and digital data signals over the laser link for speed and direction control.

  14. QTL list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...Policy | Contact Us QTL list - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ... ...es and/or papers. Data analysis method - Number of data entries 1,767 entries Data item Description Scientif... Data acquisition method The information of QTLs was collected from other databas

  15. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, Oliver [Technical Univ. of Darmstadt (Germany)

    2009-11-20

    Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle

  16. Linking renewable energy CDM projects and TGC schemes: An analysis of different options

    Energy Technology Data Exchange (ETDEWEB)

    Del Rio, Pablo [Department of Economics and Business, Facultad de Ciencias Juridicas y Sociales, Universidad de Castilla-La Mancha, C/ Cobertizo de S. Pedro Martir s/n., Toledo-45071 (Spain)]. E-mail: pablo.rio@uclm.es

    2006-11-15

    Renewable energy CDM (RE-CDM) projects encourage cost-effective GHG mitigation and enhanced sustainable development opportunities for the host countries. CERs from CDM projects include the value of the former benefits (i.e., 'climate change benefits'), whereas the second can be given value through the issuing and trading of tradable green certificates (TGCs). Countries could agree to trade these TGCs, leading to additional revenues for the investors in renewable energy projects and, therefore, further encouraging the deployment of CDM projects, currently facing significant barriers. However, the design of a combination of CDM projects and TGC schemes raises several conflicting issues and leads to trade-offs. This paper analyses these issues, identifies the alternatives that may exist to link TGC schemes with RE-CDM projects and analyses the impacts of those options on different variables and actors.

  17. Identifying controlling variables for math computation fluency through experimental analysis: the interaction of stimulus control and reinforcing consequences.

    Science.gov (United States)

    Hofstadter-Duke, Kristi L; Daly, Edward J

    2015-03-01

    This study investigated a method for conducting experimental analyses of academic responding. In the experimental analyses, academic responding (math computation), rather than problem behavior, was reinforced across conditions. Two separate experimental analyses (one with fluent math computation problems and one with non-fluent math computation problems) were conducted with three elementary school children using identical contingencies while math computation rate was measured. Results indicate that the experimental analysis with non-fluent problems produced undifferentiated responding across participants; however, differentiated responding was achieved for all participants in the experimental analysis with fluent problems. A subsequent comparison of the single-most effective condition from the experimental analyses replicated the findings with novel computation problems. Results are discussed in terms of the critical role of stimulus control in identifying controlling consequences for academic deficits, and recommendations for future research refining and extending experimental analysis to academic responding are made. © The Author(s) 2014.

  18. A student's analysis of the Moi University-Linköping University exchange programme.

    Science.gov (United States)

    Mwenda, A S

    2012-11-01

    Introduction : Moi University College of Health Sciences was established in 1989. It is comprised of the schools of medicine, nursing, public health and dentistry. Since its inception, the college has been in collaboration with Linköping University in Sweden. This collaboration has taken the form of student and staff exchanges, as well as infrastructure and library improvements. This study was carried out to analyse the exchange programme and highlight some of the strengths that the exchange programme brings to the students' academic experience. Methods : A qualitative cross-sectional survey was conducted among the students who participated in the elective/exchange programme in the years 2009, 2010 and 2011. Self-administered questionnaires were completed by the participants. Additional data were obtained from the recommendations and conclusions from the reports that the students wrote after their participation in the exchange programme. Focus group discussions and key informant interviews were also carried out. Results : A total of 46 students participated in the exchange programme: 27 from Moi University and 19 from Linköping University. The disciplines of students reflected the undergraduate courses offered by these universities. The exchange programme's strengths were exposing students to new cultural settings, different healthcare system organisation and influencing future academic and personal lives, as well as making education global. The main challenge facing the exchange programme was language. Discussion : This study shows the exchange programme as a strong pillar of the medical education curriculum, enabling students to get a global perspective on their education, while exposing them to significant cultural and healthcare organisation diversity. There is a need to expand the collaboration so that more students have the opportunity to experience the overseas exchange programme.

  19. On the Performance Analysis of Free-Space Optical Links under Generalized Turbulence and Misalignment Models

    KAUST Repository

    AlQuwaiee, Hessa

    2016-11-01

    One of the potential solutions to the radio frequency (RF) spectrum scarcity problem is optical wireless communications (OWC), which utilizes the unlicensed optical spectrum. Long-range outdoor OWC are usually referred to in the literature as free-space optical (FSO) communications. Unlike RF systems, FSO is immune to interference and multi-path fading. Also, the deployment of FSO systems is flexible and much faster than optical fibers. These attractive features make FSO applicable for broadband wireless transmission such as optical fiber backup, metropolitan area network, and last mile access. Although FSO communication is a promising technology, it is negatively affected by two physical phenomenon, namely, scintillation due to atmospheric turbulence and pointing errors. These two critical issues have prompted intensive research in the last decade. To quantify the effect of these two factors on FSO system performance, we need effective mathematical models. In this work, we propose and study a generalized pointing error model based on the Beckmann distribution. Then, we aim to generalize the FSO channel model to span all turbulence conditions from weak to strong while taking pointing errors into consideration. Since scintillation in FSO is analogous to the fading phenomena in RF, diversity has been proposed too to overcome the effect of irradiance fluctuations. Thus, several combining techniques of not necessarily independent dual-branch free-space optical links were investigated over both weak and strong turbulence channels in the presence of pointing errors. On another front, improving the performance, enhancing the capacity and reducing the delay of the communication link has been the motivation of any newly developed schemes, especially for backhauling. Recently, there has been a growing interest in practical systems to integrate RF and FSO technologies to solve the last mile bottleneck. As such, we also study in this thesis asymmetric an RF-FSO dual-hop relay

  20. Temperature Regulation of Photovoltaic Module Using Phase Change Material: A Numerical Analysis and Experimental Investigation

    Directory of Open Access Journals (Sweden)

    Hasan Mahamudul

    2016-01-01

    Full Text Available This work represents an effective design of a temperature regulated PV module by integrating phase change materials for Malaysian weather condition. Through the numerical analysis and experimental investigation it has been shown that if a PCM layer of width 0.02 m of RT 35 is used as a cooling arrangement with a PV module, the surface temperature of the module is reduced by 10°C, which remains constant for a period of 4–6 hours. This reduction of temperature implies the increase in conversion efficiency of the module. Experiment as well as investigation has been carried out considering typical Malaysian weather. Obtained result has been validated by using experimental prototype and comparative analysis.

  1. Cooperative Experimental System Development - cooperative techniques beyound initial design and analysis

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1995-01-01

    , however, not limited to this development context, it may be applied for in-house or contract development as well. In system development, particularly in cooperative and experimental system development, we argue that it is necessary to analytically separate the abstract concerns, e.g. analysis, design......This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can...... be based solely on observation and detached reflection; prototyping methods often have a narrow focus on the technical construction of various kinds of prototypes; Participatory Design techniques—including the Scandinavian Cooperative Design (CD) approaches—seldom go beyond the early analysis/design...

  2. 2000 CKM-triangle analysis a critical review with updated experimental inputs and theoretical parameters

    Energy Technology Data Exchange (ETDEWEB)

    Roudeau, P.; Stocchi, A. [Laboratoire de l' Accelerateur Lineaire, 91 - Orsay (France); Ciuchini, M.; Lubicz, V. [Rome Univ., INFN (Italy); D' Agostini, G.; Franco, E.; Martinelli, G. [Rome Univ. La Sapienza and Sezione INFN, (Italy); Parodi, F. [Universita di Genova and INFN, Dipt. di Fisica (Italy)

    2000-12-01

    Within the Standard Model, a review of the current determination of the sides and angles of the CKM unitarity triangle is presented, using experimental constraints from the measurements of |{epsilon}{sub K}|, |V{sub ub}/V{sub cb}|, {delta}m{sub d} and from the limit on {delta}m{sub s}, available in September 2000. Results from the experimental search for B{sup 0}{sub s}-B-bar{sup 0}{sub s} oscillations are introduced in the present analysis using the likelihood. Special attention is devoted to the determination of the theoretical uncertainties. The purpose of the analysis is to infer regions where the parameters of interest lie with given probabilities. The BaBar '95% C.L. scanning' method is also commented. (authors)

  3. Links between Bloom's Taxonomy and Gardener's Multiple Intelligences: The Issue of Textbook Analysis

    Science.gov (United States)

    Tabari, Mahmoud Abdi; Tabari, Iman Abdi

    2015-01-01

    The major thrust of this research was to investigate the cognitive aspect of the high school textbooks and interchange series, due to their extensive use, through content analysis based on Bloom's taxonomy and Gardner's Multiple Intelligences (MI). This study embraced two perspectives in a grid in order to broaden and deepen the analysis by…

  4. Discourse, Subject, and Agency. Linking Discourse Analysis and Biographical Research with the Help of the Concept of Articulation

    Directory of Open Access Journals (Sweden)

    Tina Spies

    2009-04-01

    Full Text Available For a significant period of time biographical research did not focus on the influence of discourses on biographical narratives. In contrast, discourse analysis often disregarded the subject-constituting impact of discourses. This article deals with the theoretical question of how to work with both: discourse and subject. Therefore, I will introduce Stuart HALL's concept of articulation. Since the early 1990's HALL has been working on questions of (cultural identity. In this context he developed an understanding of subjects that enables them not only to be seen as effects of discourses, but also allows focusing on discourses in subject conceptions. Neither biographical research nor discourse analysis In German speaking countries have embraced the work of HALL. But his concept of articulation could link biographical research and discourse analysis, and could also be used for further empirical work. URN: urn:nbn:de:0114-fqs0902369

  5. {sup 15}N/{sup 14}N isotopic ratio and statistical analysis: an efficient way of linking seized Ecstasy tablets

    Energy Technology Data Exchange (ETDEWEB)

    Palhol, Fabien; Lamoureux, Catherine; Chabrillat, Martine; Naulet, Norbert

    2004-05-10

    In this study, the {sup 15}N/{sup 14}N isotopic ratios of 106 samples of 3,4-methylenedioxymethamphetamine (MDMA) extracted from Ecstasy tablets are presented. These ratios, measured using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS), show a large discrimination between samples with a range of {delta}{sup 15}N values between -17 and +19%o, depending on the precursors and the method used in clandestine laboratories. Thus, {delta}{sup 15}N values can be used in a statistical analysis carried out in order to link Ecstasy tablets prepared with the same precursors and synthetic pathway. The similarity index obtained after principal component analysis and hierarchical cluster analysis appears to be an efficient way to group tablets seized in different places.

  6. Mass spectrometric analysis of a UV-cross-linked protein-DNA complex: tryptophans 54 and 88 of E. coli SSB cross-link to DNA

    DEFF Research Database (Denmark)

    Steen, H; Petersen, J; Mann, M

    2001-01-01

    spectrometry is becoming increasingly popular for characterization of purified peptide-nucleic acid heteroconjugates derived from UV cross-linked protein-nucleic acid complexes. The efficiency of mass spectrometry-based methods is, however, hampered by the contrasting physico-chemical properties of nucleic...

  7. Improving oral reading fluency: a brief experimental analysis of combining an antecedent intervention with consequences.

    OpenAIRE

    Eckert, Tanya L.; Ardoin, Scott P.; Daly, Edward J; Martens, Brian K.

    2002-01-01

    A brief experimental analysis was used to evaluate the relative effectiveness of combining two consequences (contingent reinforcement or performance feedback) with an antecedent intervention (listening passage preview and repeated readings) on the oral reading fluency of 6 elementary students. The antecedent intervention increased the number of correctly read words per minute for all 6 students. For 4 of the students, pairing the antecedent intervention with either of the consequences resulte...

  8. Does early-life diet affect longevity? A meta-analysis across experimental studies

    OpenAIRE

    English, Sinead; Uller, Tobias

    2016-01-01

    Life-history theory predicts that nutrition influences lifespan owing to trade-offs between allocating resources to reproduction, growth and repair. Despite occasional reports that early diet has strong effects on lifespan, it is unclear whether this prediction is generally supported by empirical studies. We conducted a meta-analysis across experimental studies manipulating pre- or post-natal diet and measuring longevity. We found no overall effect of early diet on lifespan. We used meta-regr...

  9. The etymology of basic concepts in the experimental analysis of behavior.

    OpenAIRE

    Dinsmoor, James A.

    2004-01-01

    The origins of many of the basic concepts used in the experimental analysis of behavior can be traced to Pavlov's (1927/1960) discussion of unconditional and conditional reflexes in the dog, but often with substantial changes in meaning (e.g., stimulus, response, and reinforcement). Other terms were added by Skinner (1938/1991) to describe his data on the rate of lever pressing in the rat (e.g., operant conditioning, conditioned reinforcement, negative reinforcement, and response induction an...

  10. Experimental Demonstration and Theoretical Analysis of Slow Light in a Semiconductor Waveguide at GHz Frequencies

    DEFF Research Database (Denmark)

    Mørk, Jesper; Kjær, Rasmus; Poel, Mike van der

    2005-01-01

    Experimental demonstration and theoretical analysis of slow light in a semiconductor waveguide at GHz frequencies slow-down of light by a factor of two in a semiconductor waveguide at room temperature with a bandwidth of 16.7 GHz using the effect of coherent pulsations of the carrier density. The......-explained by a model accounting for the absorption saturation in the waveguide, when using a lifetime that depends on the reverse bias....

  11. Experimental analysis of the breakage of a liquid bridge under microgravity conditions

    Science.gov (United States)

    Martínez, I.; Perales, J. M.

    2011-08-01

    The experimental results obtained in experiment "STACO" made on board the Spacelab D-2 are re-visited, with image-analysis tools not then available. The configuration consisted of a liquid bridge between two solid supporting discs. An expected breakage occurred during the experiment. The recorded images are analysed and the measured behaviour compared with the results of a three dimensional model of the liquid dynamics, obtaining a much better fit than with linear models.

  12. Transcriptomic meta-analysis of multiple sclerosis and its experimental models.

    Directory of Open Access Journals (Sweden)

    Barbara B R Raddatz

    Full Text Available BACKGROUND: Multiple microarray analyses of multiple sclerosis (MS and its experimental models have been published in the last years. OBJECTIVE: Meta-analyses integrate the information from multiple studies and are suggested to be a powerful approach in detecting highly relevant and commonly affected pathways. DATA SOURCES: ArrayExpress, Gene Expression Omnibus and PubMed databases were screened for microarray gene expression profiling studies of MS and its experimental animal models. STUDY ELIGIBILITY CRITERIA: Studies comparing central nervous system (CNS samples of diseased versus healthy individuals with n >1 per group and publically available raw data were selected. MATERIAL AND METHODS: Included conditions for re-analysis of differentially expressed genes (DEGs were MS, myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE in rats, proteolipid protein-induced EAE in mice, Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD, and a transgenic tumor necrosis factor-overexpressing mouse model (TNFtg. Since solely a single MS raw data set fulfilled the inclusion criteria, a merged list containing the DEGs from two MS-studies was additionally included. Cross-study analysis was performed employing list comparisons of DEGs and alternatively Gene Set Enrichment Analysis (GSEA. RESULTS: The intersection of DEGs in MS, EAE, TMEV-IDD, and TNFtg contained 12 genes related to macrophage functions. The intersection of EAE, TMEV-IDD and TNFtg comprised 40 DEGs, functionally related to positive regulation of immune response. Over and above, GSEA identified substantially more differentially regulated pathways including coagulation and JAK/STAT-signaling. CONCLUSION: A meta-analysis based on a simple comparison of DEGs is over-conservative. In contrast, the more experimental GSEA approach identified both, a priori anticipated as well as promising new candidate pathways.

  13. Numerical analysis of temperature field during hardfacing process and comparison with experimental results

    Directory of Open Access Journals (Sweden)

    Lazić Vukić N.

    2014-01-01

    Full Text Available The three-dimensional transient nonlinear thermal analysis of the hard facing process is performed by using the finite element method. The simulations were executed on the open source Salome platform using the open source finite element solver Code_Aster. The Gaussian double ellipsoid was selected in order to enable greater possibilities for the calculation of the moving heat source. The numerical results were compared with available experimental results.

  14. An Experimental-Theoretical Analysis of Protein Adsorption on Peptidomimetic Polymer Brushes

    OpenAIRE

    Lau, K. H. Aaron; Ren, Chunlai; Park, Sung Hyun; Szleifer, Igal; Messersmith, Phillip B.

    2011-01-01

    Surface-grafted water soluble polymer brushes are being intensely investigated for preventing protein adsorption to improve biomedical device function, prevent marine fouling, and enable applications in biosensing and tissue engineering. In this contribution, we present an experimental-theoretical analysis of a peptidomimetic polymer brush system with regard to the critical brush density required for preventing protein adsorption at varying chain lengths. A mussel adhesive-inspired DOPA-Lys p...

  15. Chemometrics in analytical chemistry-part I: history, experimental design and data analysis tools.

    Science.gov (United States)

    Brereton, Richard G; Jansen, Jeroen; Lopes, João; Marini, Federico; Pomerantsev, Alexey; Rodionova, Oxana; Roger, Jean Michel; Walczak, Beata; Tauler, Romà

    2017-10-01

    Chemometrics has achieved major recognition and progress in the analytical chemistry field. In the first part of this tutorial, major achievements and contributions of chemometrics to some of the more important stages of the analytical process, like experimental design, sampling, and data analysis (including data pretreatment and fusion), are summarised. The tutorial is intended to give a general updated overview of the chemometrics field to further contribute to its dissemination and promotion in analytical chemistry.

  16. A multi-level analysis of the EU linking directive process: the controversial connection between EU and global climate policy

    Energy Technology Data Exchange (ETDEWEB)

    Flaam, Karoline Haegstad

    2007-10-15

    Despite initial scepticism in the EU towards the Kyoto Protocol's project mechanisms (the CDM and JI), the 'Linking Directive' was adopted in October 2004, connecting the EU emissions trading scheme with the project mechanisms. Not only was the Linking Directive settled remarkably quickly, the decision-making process also left a more liberal text, with fewer restrictions on the use of the project mechanisms, as compared to the initial directive proposal. This report examines possible explanations to this puzzle, evaluating whether Member State preferences, EU institutions or external influence from the climate regime best can contribute to understanding the process. On the basis of the analysis of written sources stemming from the decision-making process, as well as seven in-depth interviews, the report finds that Member State preferences were the main driver in the Linking Directive process. This gives support to the intergovernmentalist mantra, that Member States are the main decision-makers in the EU. It also challenges much recent research claiming that EU policy-making is increasingly being taken out of the hands of the nation-state and into supranational actors such as the Commission and the European Parliament. (author). 41 refs., figs., tabs

  17. Skin biopsy is a practical approach for the clinical diagnosis and molecular genetic analysis of X-linked Alport's syndrome.

    Science.gov (United States)

    Wang, Fang; Zhao, Dan; Ding, Jie; Zhang, Hongwen; Zhang, Yanqin; Yu, Lixia; Xiao, Huijie; Yao, Yong; Zhong, Xuhui; Wang, Suxia

    2012-11-01

    A total of 209 unrelated patients of predominantly Han Chinese ethnicity and with X-linked Alport's syndrome, a clinically heterogeneous hereditary nephritis, were enrolled in the present study to evaluate the ability to make a clinical diagnosis and perform molecular genetics analysis using skin biopsy. A negative or mosaic α5(IV) chain staining in the epidermal basement membrane was detected in 86.2% of male and 93.5% of female patients. COL4A5 mutations were identified in 85% of male patients with a negative α5(IV) chain staining pattern in the epidermal basement membrane. With use of skin biopsy and immunostaining, 16.4% of our patients were diagnosed before 3 years of age, and the youngest was diagnosed at 1 year of age. COL4A5 mutations were detected in 22 patients with normal epidermal basement membrane staining for the α5(IV) chain. Analysis of COL4A5 cDNA fragments from skin fibroblasts yielded a mutation detection rate of 83%, which was particularly valuable for identification of cryptic splicing mutations. Furthermore, 83% of COL4A5 mutations identified in the present study were novel. Thus, skin biopsy is a practical approach for the clinical diagnosis and molecular genetic analysis of X-linked Alport's syndrome. Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  18. Experimental 2.5 Gbit/s QPSK WDM coherent phase modulated radio-over-fibre link with digital demodulation by a K-means algorithm

    DEFF Research Database (Denmark)

    Guerrero Gonzalez, Neil; Caballero Jambrina, Antonio; Amaya Fernández, Ferney Orlando

    2009-01-01

    Highest reported bit rate of 2.5 Gbit/s for optically phase modulated radio-over-fibre link employing coherent detection is demonstrated. Demodulation of 3·2.5 Gbit/s QPSK modulated WDM channels, is achieved after 79km of transmission through deployed fiber.......Highest reported bit rate of 2.5 Gbit/s for optically phase modulated radio-over-fibre link employing coherent detection is demonstrated. Demodulation of 3·2.5 Gbit/s QPSK modulated WDM channels, is achieved after 79km of transmission through deployed fiber....

  19. Experimental and Numerical Analysis of Screw Fixation in Anterior Cruciate Ligament Reconstruction

    Science.gov (United States)

    Chizari, Mahmoud; Wang, Bin; Snow, Martyn; Barrett, Mel

    2008-09-01

    This paper reports the results of an experimental and finite element analysis of tibial screw fixation in anterior cruciate ligament (ACL) reconstruction. The mechanical properties of the bone and tendon graft are obtained from experiments using porcine bone and bovine tendon. The results of the numerical study are compared with those from mechanical testing. Analysis shows that the model may be used to establish the optimum placement of the tunnel in anterior cruciate ligament reconstruction by predicting mechanical parameters such as stress, strain and displacement at regions in the tunnel wall.

  20. Experimental research and finite element analysis of bridge piers failed in flexure-shear modes

    Science.gov (United States)

    Sun, Zhiguo; Si, Bingjun; Wang, Dongsheng; Guo, Xun

    2008-12-01

    In recent earthquakes, a large number of reinforced concrete (RC) bridges were severely damaged due to mixed flexure-shear failure modes of the bridge piers. An integrated experimental and finite element (FE) analysis study is described in this paper to study the seismic performance of the bridge piers that failed in flexure-shear modes. In the first part, a nonlinear cyclic loading test on six RC bridge piers with circular cross sections is carried out experimentally. The damage states, ductility and energy dissipation parameters, stiffness degradation and shear strength of the piers are studied and compared with each other. The experimental results suggest that all the piers exhibit stable flexural response at displacement ductilities up to four before exhibiting brittle shear failure. The ultimate performance of the piers is dominated by shear capacity due to significant shear cracking, and in some cases, rupturing of spiral bars. In the second part, modeling approaches describing the hysteretic behavior of the piers are investigated by using ANSYS software. A set of models with different parameters is selected and evaluated through comparison with experimental results. The influences of the shear retention coefficients between concrete cracks, the Bauschinger effect in longitudinal reinforcement, the bond-slip relationship between the longitudinal reinforcement and the concrete and the concrete failure surface on the simulated hysteretic curves are discussed. Then, a modified analysis model is presented and its accuracy is verified by comparing the simulated results with experimental ones. This research uses models available in commercial FE codes and is intended for researchers and engineers interested in using ANSYS software to predict the hysteretic behavior of reinforced concrete structures.

  1. Experimental and numerical analysis of fluid flow in pipe - like conduits

    Science.gov (United States)

    Mendo-Pérez, Gerardo M.; Arciniega-Ceballos, Alejandra; Guzmán-Vázquez, José E.; Sánchez-Sesma, Francisco J.

    2017-04-01

    Volcanic activity is complex and it is a good example of multiscale phenomenon due to the sundry processes that occur at different scales while fluids ascend from the magmatic reservoirs to volcanic vents. Several processes occur at their own time scale and within a wide range of strengths. Each process contributes with its particular elastic response to the overall stress-strain field of the conduit dynamics. In this work, we present experimental and numerical analysis of fluid flowing through pipe-like conduits in order to understand the dynamic of the volcanic eruptions and its effects on the seismic signals. We focused on the elastic response of cylindrical conduits due to the flow of viscous Newtonian fluids (0.001 and 1 Pa s) passing through them. We compared signals obtained experimentally with those calculated by numerical modeling. The experimental signals are recorded with high dynamic range piezoelectric sensors located along the conduit where the fluid flows due to a sudden pressure drop. The numerical counterparts are calculated through a scheme that involves the continuity and motion equations for fluids, where the fluid couples with the surrounding solid; the excitation function simulates a pressure drop, in the range of the experimental values. In both, the excitation is considered an instantaneous pressure drop from maximum 3 bar to ambient pressure. The analysis of these observations included video recording of the process with a high speed camera. The dynamic behavior of experimental and numerical simulations present high similarity with field volcanic signals associated with pressurization processes. Our studies contributes to the understanding volcanic phenomenon and its effects on field base seismograms.

  2. A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

    Energy Technology Data Exchange (ETDEWEB)

    Fawzi, Nicolas L. [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Fleissner, Mark R. [University of California, Jules Stein Eye Institute and Department of Chemistry and Biochemistry (United States); Anthis, Nicholas J. [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States); Kalai, Tamas; Hideg, Kalman [University of Pecs, Institute of Organic and Medicinal Chemistry (Hungary); Hubbell, Wayne L., E-mail: hubbellw@jsei.ucla.edu [University of California, Jules Stein Eye Institute and Department of Chemistry and Biochemistry (United States); Clore, G. Marius, E-mail: mariusc@mail.nih.gov [National Institutes of Health, Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases (United States)

    2011-09-15

    The measurement of {sup 1}H transverse paramagnetic relaxation enhancement (PRE) has been used in biomolecular systems to determine long-range distance restraints and to visualize sparsely-populated transient states. The intrinsic flexibility of most nitroxide and metal-chelating paramagnetic spin-labels, however, complicates the quantitative interpretation of PREs due to delocalization of the paramagnetic center. Here, we present a novel, disulfide-linked nitroxide spin label, R1p, as an alternative to these flexible labels for PRE studies. When introduced at solvent-exposed {alpha}-helical positions in two model proteins, calmodulin (CaM) and T4 lysozyme (T4L), EPR measurements show that the R1p side chain exhibits dramatically reduced internal motion compared to the commonly used R1 spin label (generated by reacting cysteine with the spin labeling compound often referred to as MTSL). Further, only a single nitroxide position is necessary to account for the PREs arising from CaM S17R1p, while an ensemble comprising multiple conformations is necessary for those observed for CaM S17R1. Together, these observations suggest that the nitroxide adopts a single, fixed position when R1p is placed at solvent-exposed {alpha}-helical positions, greatly simplifying the interpretation of PRE data by removing the need to account for the intrinsic flexibility of the spin label.

  3. Objective Endoscopic Analysis with Linked Color Imaging regarding Gastric Mucosal Atrophy: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Kazuhiro Mizukami

    2017-01-01

    Full Text Available Objectives. We aimed to determine whether linked color imaging (LCI, a new image-enhanced endoscopy that enhances subtle differences in mucosal colors, can distinguish the border of endoscopic mucosal atrophy. Methods. This study included 30 patients with atrophic gastritis. In endoscopy, we continuously took images in the same composition with both LCI and white light imaging (WLI. In each image, the color values of atrophic and nonatrophic mucosae were quantified using the International Commission on Illumination 1976 (L∗, a∗, b∗ color space. Color differences at the atrophic border, defined as Euclidean distances of color values between the atrophic and nonatrophic mucosae, were compared between WLI and LCI for the overall cohort and separately for patients with Helicobacter pylori infection status. Results. We found that the color difference became significantly higher with LCI than with WLI in the overall samples of 90 points in 30 patients. LCI was 14.79 ± 6.68, and WLI was 11.06 ± 5.44 (P<0.00001. LCI was also more effective in both of the Helicobacter pylori-infected group (P=0.00003 and the Helicobacter pylori-eradicated group (P=0.00002. Conclusions. LCI allows clear endoscopic visualization of the atrophic border under various conditions of gastritis, regardless of Helicobacter pylori infection status.

  4. Electrification pathways for Kenya-linking spatial electrification analysis and medium to long term energy planning

    Science.gov (United States)

    Moksnes, Nandi; Korkovelos, Alexandros; Mentis, Dimitrios; Howells, Mark

    2017-09-01

    In September 2015 UN announced 17 Sustainable Development goals (SDG) from which goal number 7 envisions universal access to modern energy services for all by 2030. In Kenya only about 46% of the population currently has access to electricity. This paper analyses hypothetical scenarios, and selected implications, investigating pathways that would allow the country to reach its electrification targets by 2030. Two modelling tools were used for the purposes of this study, namely OnSSET and OSeMOSYS. The tools were soft-linked in order to capture both the spatial and temporal dynamics of their nature. Two electricity demand scenarios were developed representing low and high end user consumption goals respectively. Indicatively, results show that geothermal, coal, hydro and natural gas would consist the optimal energy mix for the centralized national grid. However, in the case of the low demand scenario a high penetration of stand-alone systems is evident in the country, reaching out to approximately 47% of the electrified population. Increasing end user consumption leads to a shift in the optimal technology mix, with higher penetration of mini-grid technologies and grid extension.

  5. The link between alcohol use and aggression toward sexual minorities: an event-based analysis.

    Science.gov (United States)

    Parrott, Dominic J; Gallagher, Kathryn E; Vincent, Wilson; Bakeman, Roger

    2010-09-01

    The current study used an event-based assessment approach to examine the day-to-day relationship between heterosexual men's alcohol consumption and perpetration of aggression toward sexual minorities. Participants were 199 heterosexual drinking men between the ages of 18-30 who completed (1) separate timeline followback interviews to assess alcohol use and aggression toward sexual minorities during the past year, and (2) written self-report measures of risk factors for aggression toward sexual minorities. Results indicated that aggression toward sexual minorities was twice as likely on a day when drinking was reported than on nondrinking days, with over 80% of alcohol-related aggressive acts perpetrated within the group context. Patterns of alcohol use (i.e., number of drinking days, mean drinks per drinking day, number of heavy drinking days) were not associated with perpetration after controlling for demographic variables and pertinent risk factors. Results suggest that it is the acute effects of alcohol, and not men's patterns of alcohol consumption, that facilitate aggression toward sexual minorities. More importantly, these data are the first to support an event-based link between alcohol use and aggression toward sexual minorities (or any minority group), and provide the impetus for future research to examine risk factors and mechanisms for intoxicated aggression toward sexual minorities and other stigmatized groups.

  6. A new measure based on degree distribution that links information theory and network graph analysis.

    Science.gov (United States)

    Hadley, Michael W; McGranaghan, Matt F; Willey, Aaron; Liew, Chun Wai; Reynolds, Elaine R

    2012-06-24

    Detailed connection maps of human and nonhuman brains are being generated with new technologies, and graph metrics have been instrumental in understanding the general organizational features of these structures. Neural networks appear to have small world properties: they have clustered regions, while maintaining integrative features such as short average pathlengths. We captured the structural characteristics of clustered networks with short average pathlengths through our own variable, System Difference (SD), which is computationally simple and calculable for larger graph systems. SD is a Jaccardian measure generated by averaging all of the differences in the connection patterns between any two nodes of a system. We calculated SD over large random samples of matrices and found that high SD matrices have a low average pathlength and a larger number of clustered structures. SD is a measure of degree distribution with high SD matrices maximizing entropic properties. Phi (Φ), an information theory metric that assesses a system's capacity to integrate information, correlated well with SD - with SD explaining over 90% of the variance in systems above 11 nodes (tested for 4 to 13 nodes). However, newer versions of Φ do not correlate well with the SD metric. The new network measure, SD, provides a link between high entropic structures and degree distributions as related to small world properties.

  7. Physical-layer security analysis of PSK quantum-noise randomized cipher in optically amplified links

    Science.gov (United States)

    Jiao, Haisong; Pu, Tao; Xiang, Peng; Zheng, Jilin; Fang, Tao; Zhu, Huatao

    2017-08-01

    The quantitative security of quantum-noise randomized cipher (QNRC) in optically amplified links is analyzed from the perspective of physical-layer advantage. Establishing the wire-tap channel models for both key and data, we derive the general expressions of secrecy capacities for the key against ciphertext-only attack and known-plaintext attack, and that for the data, which serve as the basic performance metrics. Further, the maximal achievable secrecy rate of the system is proposed, under which secrecy of both the key and data is guaranteed. Based on the same framework, the secrecy capacities of various cases can be assessed and compared. The results indicate perfect secrecy is potentially achievable for data transmission, and an elementary principle of setting proper number of photons and bases is given to ensure the maximal data secrecy capacity. But the key security is asymptotically perfect, which tends to be the main constraint of systemic maximal secrecy rate. Moreover, by adopting cascaded optical amplification, QNRC can realize long-haul transmission with secure rate up to Gb/s, which is orders of magnitude higher than the perfect secrecy rates of other encryption systems.

  8. High Resolution ITRAX Analysis of Les Echets (France) Sedimentary Sequence: Linking Geochemical, Biological and Physical Proxies

    Science.gov (United States)

    Wohlfarth, B.; Kylander, M. E.; Ampel, L.; Veres, D.

    2008-12-01

    We present a 30 m long, high-resolution, independently-dated multi-proxy lake sediment record from Les Echets in south-central France which covers the later part of Marine Isotope Stage (MIS) 3 and MIS 2 (40 and 16 ka BP). The sediments in the lower part of the studied sequence are composed of alternating organic rich and minerogenic layers, while the upper part consists predominantly of silt and clay. Organic geochemical, geophysical and biological environmental indicators (grain size, mineral magnetic parameters, TOC, TN, LOI, stable carbon isotopes, rock eval, biogenic silica, and diatom assemblages) show alternating phases of higher and low lake organic productivity which are interpreted as a response to DO climate variability. XRF is a well-established analytical tool that has recently taken a new direction with the introduction of core scanning systems. The ITRAX XRF core scanning system is non-destructive, acquires continuous data for a broad range of elements in situ as well as generates radiographic images. The Les Echets sequence was analysed using the ITRAX at 1 mm resolution. The radiographic images show significant changes that were not revealed by lithostratigraphic descriptions. Distinct, dense layers are associated with changes in elemental intensities which would have been missed using traditional sub-sampling techniques. The high resolution elemental profiles show associations between certain elements (Rb, Si, Ti and K; Sr and Ca) which can be linked to lake productivity and catchment erosion and by extension, paleoclimatic changes.

  9. A new measure based on degree distribution that links information theory and network graph analysis

    Science.gov (United States)

    2012-01-01

    Background Detailed connection maps of human and nonhuman brains are being generated with new technologies, and graph metrics have been instrumental in understanding the general organizational features of these structures. Neural networks appear to have small world properties: they have clustered regions, while maintaining integrative features such as short average pathlengths. Results We captured the structural characteristics of clustered networks with short average pathlengths through our own variable, System Difference (SD), which is computationally simple and calculable for larger graph systems. SD is a Jaccardian measure generated by averaging all of the differences in the connection patterns between any two nodes of a system. We calculated SD over large random samples of matrices and found that high SD matrices have a low average pathlength and a larger number of clustered structures. SD is a measure of degree distribution with high SD matrices maximizing entropic properties. Phi (Φ), an information theory metric that assesses a system’s capacity to integrate information, correlated well with SD - with SD explaining over 90% of the variance in systems above 11 nodes (tested for 4 to 13 nodes). However, newer versions of Φ do not correlate well with the SD metric. Conclusions The new network measure, SD, provides a link between high entropic structures and degree distributions as related to small world properties. PMID:22726594

  10. Linked Partitions and Linked Cycles

    OpenAIRE

    Chen, William Y. C.; Wu, Susan Y. J.; Yan, Catherine H.

    2006-01-01

    The notion of noncrossing linked partition arose from the study of certain transforms in free probability theory. It is known that the number of noncrossing linked partitions of [n+1] is equal to the n-th large Schroder number $r_n$, which counts the number of Schroder paths. In this paper we give a bijective proof of this result. Then we introduce the structures of linked partitions and linked cycles. We present various combinatorial properties of noncrossing linked partitions, linked partit...

  11. Exploring the genetics underlying autoimmune diseases with network analysis and link prediction

    KAUST Repository

    Alanis Lobato, Gregorio

    2014-02-01

    Ever since the first Genome Wide Association Study (GWAS) was carried out we have seen an important number of discoveries of biological and clinical relevance. However, there are some scientists that consider that these research outcomes and their utility are far from what was expected from this experimental design. We instead believe that the thousands of genetic variants associated with complex disorders by means of GWASs are an extremely valuable source of information that needs to be mined in a different way. Based on this philosophy, we followed a holistic perspective to analyze GWAS data and explored the structural properties of the network representation of one of these datasets with the aim to advance our understanding of the genetic intricacies underlying autoimmune human diseases. The simplicity, computational efficiency and precision of the tools proposed in this paper represent a new means to address GWAS data and contribute to the better exploitation of these rich sources of information. © 2014 IEEE.

  12. Preserving and maintaining vital Ecosystem Services: the importance of linking knowledge from Geosciences and social-ecological System analysis

    Science.gov (United States)

    Finger, David; Petursdottir, Thorunn

    2013-04-01

    Human kind has always been curios and motivated to understand and quantify environmental processes in order to predict and anticipate the evolution of vital ecosystem services. Even the very first civilizations used empirical correlations to predict outcomes of rains and subsequent harvest efficiencies. Along with the insights into the functioning of ecosystems, humans also became aware that their anthropogenic activities can have positive and negative impact on ecosystem services. In recent years, geosciences have brought forward new sophisticated observations and modeling tools, with the aim to improve predictions of ecological developments. At the same time, the added value of linking ecological factors to the surrounding social structure has received a growing acceptance among scientists. A social-ecological system approach brings in a holistic understanding of how these systems are inevitably interlinked and how their sustainability can be better maintained. We claim that the biggest challenge for geoscience in the coming decades will be to link these two disciplines in order to establish adequate strategies to preserve natural ecosystems and their services, parallel to their utilization. We will present various case studies from more than a decade of research, ranging from water quality in mountain lakes, climate change impacts on water availability and declining fishing yields in freshwaters and discuss how the studies outcomes could be given added value by interpreting them via social-ecological system analysis. For instance, sophisticated field investigations revealed that deep water mixing in lake Issyk-Kul, Kirgizstan, is intensively distributing pollutants in the entire lake. Although fishery is an important sector in the region, the local awareness of the importance of water quality is low. In Switzerland, strict water protection laws led to ologotrophication of alpine lakes, reducing fishing yields. While local fishermen argued that local fishery is

  13. Usability analysis of the tele-nursing call management software at HealthLink BC.

    Science.gov (United States)

    Hall, Simon A S; Kushniruk, Andre W; Borycki, Elizabeth M

    2011-01-01

    Usability engineering methods have been shown to be effective in identifying software problems that may lead to user operating inefficiencies, user errors, data encoding errors or far more serious health threatening consequences. This research project applied two complementary usability engineering analysis methods to a mature tele-nursing clinical call management software platform (a knowledgebase and an EMR product). Findings from the study revealed 100 discrete usability errors or problems. This research also introduced an adaptation of cognitive task analysis, with the development of a 'cognitive task screen-turn' analysis, which provided useful information about operating differences among users performing identical tasks that was particularly useful in revealing four unnecessary steps within the system.

  14. Links between Bloom's Taxonomy and Gardener's Multiple Intelligences: The issue of Textbook Analysis

    Directory of Open Access Journals (Sweden)

    Mahmoud Abdi Tabari

    2015-02-01

    Full Text Available The major thrust of this research was to investigate the cognitive aspect of the high school textbooks and interchange series, due to their extensive use, through content analysis based on Bloom's taxonomy and Gardner's Multiple Intelligences (MI. This study embraced two perspectives in a grid in order to broaden and deepen the analysis by determining the numbers and the types of intelligences with respect to their learning objectives tapped in the textbooks and comparing them. Through codification of Bloom’s learning objectives and Gardner's MI, the results showed that there was a significant difference between the numbers of intelligences with respect to their learning objectives in the textbooks. However, the interchange series enjoyed a large number of the spatial and the interpersonal intelligences across eight levels of learning objectives, whereas they had the least number of the intrapersonal, the musical, and the bodily-kinesthetic intelligences across knowledge understanding and application levels. Keywords: learning objectives, multiple intelligences, textbook analysis

  15. Investigating the Link Between Climate and Leptospirosis in the Caribbean Using Wavelet Analysis.

    Science.gov (United States)

    Batchelor, T. W.; Amarakoon, D.; Taylor, M. A.; Stephenson, T.

    2009-05-01

    The Caribbean has shown changes in its climate (temperature and rainfall) as a result of urbanisation, population growth and industrialisation. The climatic changes have implications for the emergence and re- emergence of rodent-borne diseases such as leptospirosis. In this paper wavelet analysis is used to investigate the relationship between the incidence of leptospirosis in the Caribbean and climate variables such as temperature and precipitation. Wavelet analysis takes into account characteristics unique to climate and epidemiological data which other spectral techniques failed to do. The analysis reveals 2-3 year periodic signals in both the wavelet power spectrum and wavelet coherency. There is also a correlation between incidence of leptospirosis and late season Caribbean rainfall.

  16. Experimental design and instability analysis of coaxial electrospray process for microencapsulation of drugs and imaging agents.

    Science.gov (United States)

    Si, Ting; Zhang, Leilei; Li, Guangbin; Roberts, Cynthia J; Yin, Xiezhen; Xu, Ronald

    2013-07-01

    Recent developments in multimodal imaging and image-guided therapy requires multilayered microparticles that encapsulate several imaging and therapeutic agents in the same carrier. However, commonly used microencapsulation processes have multiple limitations such as low encapsulation efficiency and loss of bioactivity for the encapsulated biological cargos. To overcome these limitations, we have carried out both experimental and theoretical studies on coaxial electrospray of multilayered microparticles. On the experimental side, an improved coaxial electrospray setup has been developed. A customized coaxial needle assembly combined with two ring electrodes has been used to enhance the stability of the cone and widen the process parameter range of the stable cone-jet mode. With this assembly, we have obtained poly(lactide-co-glycolide) microparticles with fine morphology and uniform size distribution. On the theoretical side, an instability analysis of the coaxial electrified jet has been performed based on the experimental parameters. The effects of process parameters on the formation of different unstable modes have been studied. The reported experimental and theoretical research represents a significant step toward quantitative control and optimization of the coaxial electrospray process for microencapsulation of multiple drugs and imaging agents in multimodal imaging and image-guided therapy.

  17. Advanced Laboratory at Texas State University: Error Analysis, Experimental Design, and Research Experience for Undergraduates

    Science.gov (United States)

    Ventrice, Carl

    2009-04-01

    Physics is an experimental science. In other words, all physical laws are based on experimentally observable phenomena. Therefore, it is important that all physics students have an understanding of the limitations of certain experimental techniques and the associated errors associated with a particular measurement. The students in the Advanced Laboratory class at Texas State perform three detailed laboratory experiments during the semester and give an oral presentation at the end of the semester on a scientific topic of their choosing. The laboratory reports are written in the format of a ``Physical Review'' journal article. The experiments are chosen to give the students a detailed background in error analysis and experimental design. For instance, the first experiment performed in the spring 2009 semester is entitled Measurement of the local acceleration due to gravity in the RFM Technology and Physics Building. The goal of this experiment is to design and construct an instrument that is to be used to measure the local gravitational field in the Physics Building to an accuracy of ±0.005 m/s^2. In addition, at least one of the experiments chosen each semester involves the use of the research facilities within the physics department (e.g., microfabrication clean room, surface science lab, thin films lab, etc.), which gives the students experience working in a research environment.

  18. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    Directory of Open Access Journals (Sweden)

    Marcin Luczak

    2014-01-01

    Full Text Available This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement outcomes.

  19. Econometric analysis of the link between public transport accessibility and employment

    OpenAIRE

    Johnson, D.; Ercolani, M.; Mackie, P

    2017-01-01

    Modern transport policy analysis has ceased to be mainly about transport impacts and is now focussed on the effects of provision and policy upon the operation of the economy and society. For people on the edge of the labour market, many of whom do not have access to other forms of transport, public transport is a very important source of accessibility to jobs. This analysis addresses what we see as a key research gap in Britain - whether there is a systematic variation in the level of employm...

  20. Analysis of the link between a definition of sustainability and the life cycle methodologies

    DEFF Research Database (Denmark)

    Jørgensen, Andreas; Herrmann, Ivan Tengbjerg; Bjørn, Anders

    2013-01-01

    explicit analysis of the claim has been made. The purpose of this article is to analyse this claim.An interpretation of the goals of sustainability, as outlined in the report Our Common Future (WCED 1987), which is the basis for most literature on sustainability assessment in the LCA community......, is presented and detailed to a level enabling an analysis of the relation to the impact categories at midpoint level considered in life cycle (LC) methodologies.The interpretation of the definition of sustainability as outlined in Our Common Future (WCED 1987) suggests that the assessment of a product...