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Sample records for exemption ide process

  1. Lessons Learned From The Investigational Device Exemption (IDE) Review of Children's Oncology Group Trial AAML1031

    Science.gov (United States)

    Meshinchi, Soheil; Hunger, Stephen P.; Aplenc, Richard; Adamson, Peter C.; Jessup, J. Milburn

    2012-01-01

    The FDA is now exerting its regulatory authority over molecular diagnostics and their assays used for medical-decision making in clinical trials by performing pre-Investigational Device Exemption (IDE) reviews in all phases of clinical trials. This review assesses the analytical performance of the assay for the diagnostic and considers how that performance affects the diagnostic and the patient and their risks and benefits from treatment. This manuscript reviews the process of the first review that was performed on a new Children's Oncology Group (COG) Phase III trial in Acute Myelogenous Leukemia. The lessons learned and recommendations for how to prepare for and incorporate this new level of regulatory review into the protocol development process are presented. PMID:22422407

  2. Proteolytic processing of the streptococcal IgG endopeptidase IdeS modulates the functional properties of the enzyme and results in reduced immunorecognition.

    Science.gov (United States)

    Persson, Helena; Söderberg, Jenny Johansson; Vindebro, Reine; Johansson, Björn P; von Pawel-Rammingen, Ulrich

    2015-12-01

    The important human gram positive bacterial pathogen Streptococcus pyogenes employs various virulence factors to promote inflammation and to facilitate invasive disease progression. In this study we explored the relation of the secreted streptococcal cysteine proteases IdeS and SpeB, and neutrophil (PMN) proteases. We found that SpeB is resistant to proteolytic attack in an inflammatory environment, emphasizing the importance of SpeB for streptococcal pathogenicity, while PMN enzymes and SpeB itself process the IgG degrading endopeptidase IdeS. Processing occurs as NH2-terminal cleavage of IdeS resulting in reduced immunorecognition of the protease by specific antibodies. While the endopeptidase retains IgG cleaving activity, its ability to suppress the generation of reactive oxygen species is abolished. We suggest that the cleavage of NH2-terminal peptides by SpeB and/or neutrophil proteases is a mechanism evolved to prevent early inactivation of this important streptococcal virulence factor, albeit at the cost of impaired functionality. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. 29 CFR 780.806 - Exempt ginning limited to first processing.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Exempt ginning limited to first processing. 780.806 Section... Employment in Ginning of Cotton and Processing of Sugar Beets, Sugar-Beet Molasses, Sugarcane, or Maple Sap into Sugar or Syrup; Exemption From Overtime Pay Requirements Under Section 13(b)(15) Ginning of Cotton...

  4. Alongamento do processo estilóide (síndrome de Eagle: relato de dois casos Elongated styloid process (Eagle syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Domingues de Sá

    2004-10-01

    Full Text Available O alongamento do processo estilóide, ou síndrome de Eagle, representa uma afecção multifatorial com características inespecíficas na análise do quadro clínico e no estudo por imagem. A utilização dos métodos de imagem, em associação aos sinais e sintomas, é de grande utilidade na confirmação diagnóstica, mostrando a extensão do complexo estilóide, os músculos e ligamentos que o compõem e as estruturas adjacentes. O diagnóstico é firmado quando se tem a associação das informações clínicas com os exames de imagem. Os autores descrevem dois casos de alongamento do processo estilóide e seus aspectos de imagem, principalmente por meio da tomografia computadorizada.Elongated styloid process or Eagle's syndrome is a multifactorial disease with unspecific characteristics on clinical and imaging examinations. The use of imaging methods in combination with the signs and symptoms are valuable in the confirmation of the diagnosis since they show the extension of the styloid complex, the muscles and ligaments, and adjacent structures. The diagnosis can be established when there is an association of clinical information and imaging findings. The authors report two cases of elongated styloid process including the imaging findings, mainly obtained using computed tomography.

  5. Diagnostic reproducibility of the elongated styloid process Reprodutibilidade diagnóstica do alongamento do processo estilóide

    Directory of Open Access Journals (Sweden)

    Gulnara Scaf

    2003-06-01

    Full Text Available The aim of this study was to estimate the reproducibility related to the presence and to the measurements of elongated styloid process (ESP, based on panoramic radiographs and the prevalence of ESP. Experimental design: one hundred sixty six panoramic radiographs were used, from edentulous patients from the Radiology Clinic files, at Araraquara Dental School, Unesp, during a four-year period. One hundred and twenty one were female and 45 were male. Two calibrated observers evaluated the radiographs. A caliper was used to measure, in mm, the ESP from the base of the temporal bone to the tip of the structure. The ESP was considered present when the measurements were 30mm or more. Kappa statistics (k and intra-class correlation coefficient (r , were applied to estimate the reproducibility. The results showed that related to the presence of ESP, the interobserver agreement was k =0.85. Related to the measurements of ESP, the interobserver agreement was r =0.52. The prevalence of ESP was estimated in 12.6%. ESP distribution in females was similar to that for males. In conclusion, we found a greater level of agreement when observers evaluated the presence of ESP than when they did the measurement of ESP. The prevalence of ESP was 12.6%.O objetivo deste trabalho foi avaliar a reprodutibilidade relacionada à presença e às medidas do alongamento e a prevalência do processo estilóide (APE, utilizando radiografias panorâmicas. Foram utilizadas cento e sessenta e seis radiografias, do arquivo da Clínica de Radiologia, da Faculdade de Odontologia de Araraquara, Unesp, de pacientes desdentados, atendidos num período de quatro anos. Cento e vinte um pacientes eram do gênero feminino e quarenta e cinco do masculino. Dois examinadores calibrados avaliaram as radiografias. Foi utilizado um paquímetro para medir, em mm, o APE da base do osso temporal à extremidade da estrutura. O APE foi considerado presente quando as medidas ultrapassaram 30 mm. A

  6. IdeS: a bacterial proteolytic enzyme with therapeutic potential.

    Directory of Open Access Journals (Sweden)

    Björn P Johansson

    Full Text Available BACKGROUND: IdeS, a proteinase from Streptococcus pyogenes, cleaves immunoglobulin (IgG antibodies with a unique degree of specificity. Pathogenic IgG antibodies constitute an important clinical problem contributing to the pathogenesis of a number of autoimmune conditions and acute transplant rejection. To be able to effectively remove such antibodies is therefore an important clinical challenge. METHODOLOGY/PRINCIPAL FINDINGS: IdeS was found to specifically and efficiently cleave IgG in human blood in vitro (20 microg of IdeS caused a complete degradation of IgG in one ml of human whole blood in 15 minutes and to clear IgG from the blood stream of rabbits in vivo (no IgG was detected six hours following an intravenous injection of 5 mg of IdeS without any side effects. In a mouse model of immune thrombocytopenic purpura (ITP, polyclonal IgG antibodies against platelet surface antigens were used to induce a lethal disease. These profoundly thrombocytopenic animals were treated and cured by a single injection of IdeS. CONCLUSIONS/SIGNIFICANCE: Novel information is provided concerning the IgG-cleaving activity of IdeS in vitro and in vivo. The highly specific and rapid elimination of IgG in vivo, the dramatic effect in a mouse model of ITP, and the lack of side effects in the treated animals, indicate that IdeS could also be used to treat IgG-driven diseases in humans.

  7. Instant Geany IDE

    CERN Document Server

    Quan, Nguyen Hong

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This is a practical, hands-on guide that helps you code efficiently.Instant Geany IDE is for software developers, programmers, and coders who need to optimize their time and productivity while scripting. It assumes that the reader has experience with Linux commands.

  8. Redundant arrays of IDE drives

    Energy Technology Data Exchange (ETDEWEB)

    D.A. Sanders et al.

    2002-01-02

    The authors report tests of redundant arrays of IDE disk drives for use in offline high energy physics data analysis. Parts costs of total systems using commodity EIDE disks are now at the $4000 per Terabyte level. Disk storage prices have now decreased to the point where they equal the cost per Terabyte of Storage Technology tape silos. The disks, however, offer far better granularity; even small institutions can afford to deploy systems. The tests include reports on software RAID-5 systems running under Linux 2.4 using Promise Ultra 100{trademark} disk controllers. RAID-5 protects data in case of a single disk failure by providing parity bits. Tape backup is not required. Journaling file systems are used to allow rapid recovery from crashes. The data analysis strategy is to encapsulate data and CPU processing power. Analysis for a particular part of a data set takes place on the PC where the data resides. The network is only used to put results together. They explore three methods of moving data between sites; internet transfers, not pluggable IDE disks in FireWire cases, and DVD-R disks.

  9. Harvard Catalyst | The Clinical Translational Science Center IND/IDE Consult Service: Providing an IND/IDE Consult Service in a Decentralized Network of Academic Healthcare Centers

    Science.gov (United States)

    Winkler, Sabune J.; Bierer, Barbara E.; Wolf, Delia

    2014-01-01

    Abstract The Food and Drug Administration (FDA) regulations require sponsors of clinical investigations involving an investigational drug or device to submit an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application. Strict adherence to applicable regulations is vital to the success of clinical research. Unlike most major pharmaceutical sponsors, investigator sponsors often do not fully appreciate their regulatory obligations nor have resources to ensure compliance. As a result they can place themselves and their institutions at risk. Nevertheless, investigator‐initiated clinical trials are vital to the further development of innovative drugs, biologics, and medical devices. The IND/IDE Subcommittee under the Regulatory Knowledge and Support Program at Harvard Catalyst, The Harvard Clinical and Translational Science Center worked in collaboration with Harvard and Harvard affiliated institutions to create and launch an IND/IDE Consult Service in a decentralized network of collaborating Academic Healthcare Centers (AHC). The IND/IDE Consult Service offers expertise, resources, and shared experiences to assist sponsor‐investigators and IRBs in meeting regulatory requirements for conducting and reviewing investigator‐initiated IND/IDE studies. The scope of the services provided by the Harvard Catalyst IND/IDE Consult Service are described, including the specifics of the service, lessons learned, and challenges faced, in a scalable model that builds inter‐institutional capacity. PMID:24455986

  10. Redundant Arrays of IDE Drives

    CERN Document Server

    Sanders, D A; Eschenburg, V; Lawrence, C N; Riley, C P; Summers, D J; Petravick, D L

    2001-01-01

    We report tests of redundant arrays of IDE disk drives for use in offline high energy physics data analysis. Parts costs of total systems using commodity EIDE disks are now at the $4000 per Terabyte level. Disk storage prices have now decreased to the point where they equal the cost per Terabyte of Storage Technology tape silos. The disks, however, offer far better granularity; even small institutions can afford to deploy systems. Our tests include reports on software RAID-5 systems running under Linux 2.4 using Promise Ultra 100 TM disk controllers. RAID-5 protects data in case of a single disk failure by providing parity bits. Tape backup is not required. Journaling file systems are used to allow rapid recovery from crashes. Our data analysis strategy is to encapsulate data and CPU processing power. Analysis for a particular part of a data set takes place on the PC where the data resides. The network is only used to put results together. We explore three methods of moving data between sites; internet transf...

  11. Redundant arrays of IDE drives

    Science.gov (United States)

    Sanders, D. A.; Cremaldi, L. M.; Eschenburg, V.; Lawrence, C. N.; Riley, C.; Summers, D. J.; Petravick, D. L.

    2002-08-01

    The next generation of high-energy physics experiments is expected to gather prodigious amounts of data. New methods must be developed to handle this data and make analysis at universities possible. We examine some techniques that use recent developments in commodity hardware. We test redundant arrays of integrated drive electronics (IDE) disk drives for use in offline high-energy physics data analysis. IDE redundant array of inexpensive disks (RAID) arrays prices now equal the cost per terabyte of million dollar tape robots! The arrays can be scaled to sizes affordable to institutions without robots and used when fast random access at low cost is important. We also explore three methods of moving data between sites; internet transfers, hot pluggable IDE disks in FireWire cases, and writable digital video disks (DVD-R) disks.

  12. The Spoofax language workbench rules for declarative specification of languages and IDEs

    NARCIS (Netherlands)

    Kats, L.C.L.; Visser, E.

    2010-01-01

    Spoofax is a language workbench for efficient, agile development of textual domain-specific languages with state-of-the-art IDE support. Spoofax integrates language processing techniques for parser generation, meta-programming, and IDE development into a single environment. It uses concise,

  13. Resíduos do beneficiamento do camarão cultivado: obtenção de pigmentos carotenóides Waste from the processing of farmed shrimp: a source of carotenoid pigments

    Directory of Open Access Journals (Sweden)

    Masayoshi Ogawa

    2007-06-01

    Full Text Available A extração de pigmentos carotenóides constitui uma possível alternativa, de grande agregação de valor, para o aproveitamento da cabeça do camarão Litopenaeus vannamei. O objetivo do presente trabalho foi a identificação, a extração e a quantificação dos principais pigmentos desta matéria-prima, coletados a partir de uma planta de beneficiamento de camarão no Ceará - Brasil. Após cocção dos resíduos a 100 °C, na proporção 1:2 cabeça de camarão e água durante 15 minutos, obteve-se uma pasta de pigmentos brutos extraindo-se os carotenóides com acetona resfriada e, posteriormente, com hexano, obtendo a fase pigmento-hexano. Obteve-se também a fase DMSO, após o material ser particionado com dimetilsulfóxido, e uma fração acidificada. Estas frações sofreram evaporação e secagem, sendo os carotenóides identificados em coluna aberta, utilizando-se o parâmetro de eluição das frações, o espectro de absorção visível e o valor de Rf na camada delgada de sílica gel. Os espectros de absorção de cada fração foram obtidos a 350 a 550 nm e quantificados por cromatografia de camada delgada. Para o cálculo de carotenóides totais (37,62 µg.g-1 da pasta de pigmentos, utilizou-se o somatório das frações hexano, DMSO e acidificada, e coeficientes de extinção 2592, 2100 e 1690 referentes ao beta-caroteno, astaxantina e astaceno, respectivamente. A astaxantina foi o pigmento mais abundante (45,5%, seguido do beta-caroteno-5,6-epóxido (33,5% e do astaceno (21,0%.The extraction of carotenoid pigments from shrimp heads left over from the processing of Litopenaeus vannamei has been shown to constitute an economically feasible alternative for aggregating value to shrimp processing waste. The objective of the present study was to extract, identify and quantify the main pigments found in shrimp heads collected at a shrimp processing plant in Ceará (Brazil. Samples were cooked for 15 minutes at 100 °C in water at a

  14. Determining the scope of exemptions from data subjects’ rights to process tax data

    NARCIS (Netherlands)

    van Schendel, Sascha

    2016-01-01

    Case C‑201/14 Smaranda Bara and Others [2015] For a public institution to be exempted on the basis of Article 13 of Directive 95/46/EC from complying with data subjects’ rights under the Directive, a legislative measure is required. A non-public protocol is not sufficient to qualify a legislative

  15. Adinda : A knowledgeable, browser-based IDE

    NARCIS (Netherlands)

    Van Deursen, A.; Mesbah, A.; Cornelissen, B.; Zaidman, A.; Pinzger, M.; Guzzi, A.

    2010-01-01

    In practice, many people have to work together to develop and maintain a software system. However, the programmer’s key tool, the Integrated Development Environment (IDE), is a solo-tool, serving to help individual programmers understand and modify the system. Such an IDE does not leverage the

  16. Optimization of interdigitated electrode (IDE) arrays for impedance based evaluation of Hs 578T cancer cells

    Science.gov (United States)

    Alexander, Frank, Jr.; Price, Dorielle T.; Bhansali, Shekhar

    2010-04-01

    This paper examines the effect of electrode width and spacing of interdigitated electrodes (IDEs) for impedance-based cancer detection and characterization. IDEs are desired for bioimpedance measurements because their fabrication process is simple and inexpensive, and the geometry presents a potential for improved sensitivity over other microelectrode designs. Optimizing the geometry will eliminate this problem and increase the sensitivity of these devices for bioimpedance measurement applications. This paper evaluates the effect of IDE geometry on the sensitivity of breast cancer cell impedance measurements. Equivalent circuit data analysis was conducted to quantify and characterize the cells.

  17. Formal Reasoning Using an Iterative Approach with an Integrated Web IDE

    Directory of Open Access Journals (Sweden)

    Nabil M. Kabbani

    2015-08-01

    Full Text Available This paper summarizes our experience in communicating the elements of reasoning about correctness, and the central role of formal specifications in reasoning about modular, component-based software using a language and an integrated Web IDE designed for the purpose. Our experience in using such an IDE, supported by a 'push-button' verifying compiler in a classroom setting, reveals the highly iterative process learners use to arrive at suitably specified, automatically provable code. We explain how the IDE facilitates reasoning at each step of this process by providing human readable verification conditions (VCs and feedback from an integrated prover that clearly indicates unprovable VCs to help identify obstacles to completing proofs. The paper discusses the IDE's usage in verified software development using several examples drawn from actual classroom lectures and student assignments to illustrate principles of design-by-contract and the iterative process of creating and subsequently refining assertions, such as loop invariants in object-based code.

  18. Vasculite ou vasculopatia livedóide?

    Directory of Open Access Journals (Sweden)

    Zanini Maurício

    2003-01-01

    Full Text Available Vasculite livedóide ou atrofia branca não é uma vasculite verdadeira. Acredita-se ser um distúrbio primário na fibrinólise que estabelece uma vasculopatia oclusiva. Assim, não sendo uma vasculite, a expressão vasculopatia livedóide é preferível. Essa definição fisiopatológica reflete-se em novas perspectivas terapêuticas.

  19. Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy.

    Science.gov (United States)

    Järnum, Sofia; Runström, Anna; Bockermann, Robert; Winstedt, Lena; Crispin, Max; Kjellman, Christian

    2017-09-01

    Endogenous plasma IgG sets an immunologic threshold that dictates the activity of tumor-directed therapeutic antibodies. Saturation of cellular antibody receptors by endogenous antibody limits antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Here, we show how enzymatic cleavage of IgG using the bacterial enzyme IdeS can be utilized to empty both high and low affinity Fcγ-receptors and clear the entire endogenous antibody pool. Using in vitro models, tumor animal models as well as ex vivo analysis of sera collected during a previous clinical trial with IdeS, we show how clearing of competing plasma antibody levels with IdeS unblocks cellular antibody receptors. We show that therapeutic antibodies against breast cancer (trastuzumab), colon cancer (cetuximab), and lymphomas (rituximab and alemtuzumab) can be potentiated when endogenous IgG is removed. Overall, IdeS is shown to be a potent tool to reboot the human antibody repertoire and to generate a window to preferentially load therapeutic antibodies onto effector cells and thereby create an armada of dedicated tumor-seeking immune cells. Mol Cancer Ther; 16(9); 1887-97. ©2017 AACR . ©2017 American Association for Cancer Research.

  20. Mini table de radionucléides

    CERN Document Server

    2015-01-01

    Cette table est un outil pratique et quotidien pour tous les travailleurs opérant au contact de radionucléides. Elle concerne tous les secteurs scientifiques et techniques, comme la médecine, la recherche ou l'industrie. La Mini Table de radionucléides a été conçue comme un instrument permettant de repérer et valider rapidement les principales caractéristiques des radionucléides les plus utilisés (environ 300) que l'on rencontre en milieu médical, industriel, nucléaire, gestion des déchets, etc. Présentée en format de poche, elle permet pour chaque radionucléide d'indiquer ses caractéristiques fondamentales : La période radioactive ; Le ou les principaux modes de désintégration ; Les principales émissions en termes d'énergie et d'intensité. Pour des caractéristiques complètes, l'ouvrage renvoie aux Tables de Données de référence. Au sein du CEA, le Laboratoire National Henri Becquerel (LNHB) est mandaté par le Laboratoire National de Métrologie et d'Essais (LNE) comme laboratoir...

  1. Melanoma epitelióide de coróide em adolescente: relato de caso

    Directory of Open Access Journals (Sweden)

    Araújo Ângelo Augusto

    2004-01-01

    Full Text Available O melanoma maligno de úvea é uma doença muito rara antes dos 30 anos de idade. Este é um relato de um caso de melanoma epitelióide de coróide em adolescente de 12 anos cujo diagnóstico presuntivo foi realizado por exame clínico, ressonância e ultra-sonografia sendo confirmado por meio de exame anatomopatológico.

  2. Test Marketing Exemption (TME) for New Chemical Review under TSCA

    Science.gov (United States)

    Under section 5 of TSCA, EPA established an exemption for certain chemicals that are manufactured (including imported) for test marketing. You can learn more here about the requirements of this exemption, along with the review and submission process.

  3. 40 CFR 80.1441 - Small refinery exemption.

    Science.gov (United States)

    2010-07-01

    ... refinery meets the definition of a small refinery under § 80.1401 for calendar year 2006. (2) The exemption.... (4) This exemption shall only apply to refineries that process crude oil through refinery processing... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Small refinery exemption. 80.1441...

  4. Sexing the human skull through the mastoid process Determinação do sexo em crânios humanos através do processo mastóide

    Directory of Open Access Journals (Sweden)

    Luiz Airton Saavedra de Paiva

    2003-01-01

    Full Text Available OBJECTIVE: The purpose of this study was to evaluate the significance for sex determination of the measurement of the area formed by the xerographic projection of 3 craniometric points related to the mastoid process: the porion, asterion, and mastoidale points. METHOD: Sixty skulls, 30 male and 30 female, were analyzed. A xerographic copy of each side of the skull was obtained. On each xerographic copy, the craniometric points were marked to demarcate a triangle. The area (mm² of the demarcated triangle for each side of the skull (right (D and left (E sides was determined, and the total value of these measures (T was calculated. RESULTS: Concerning the right area of the male and female skulls, 60% of the values overlapped; for the left area, 51.67% overlapped, and for the total area, 36.67% overlapped. The analysis of the differences between the sexes in the areas studied was significant for the 3 areas. Regarding the total area, which is the preferred measurement because of the asymmetry between the sides of the skull, the value of the mean was 1505.32 mm² for male skulls, which was greater than the maximum value obtained in the female skulls. The value of the mean for female skulls was 1221.24 mm², less than the minimum value obtained for the male skulls. CONCLUSIONS: This study demonstrates a significant result in the 3 studied areas, (D, (E, and (T. The total area values show less overlapping of values between the sexes, and therefore can be used for sexing human skulls. For the population studied, values of the total area that were greater than or equal to 1447.40 mm² belonged to male crania (95% confidence. Values for this area that were less than or equal to 1260.36 mm² belonged to female crania (95% confidence.OBJETIVO: Avaliar a significância da medida da área formada pela projeção xerográfica de três pontos craniométricos relacionados ao processo mastóide, que são, o porion, o asterion e o mastoidale, na determinação do

  5. Pneumonia lipóide

    Directory of Open Access Journals (Sweden)

    Gunther Kissmann

    2008-07-01

    Full Text Available Resumo: Dentre as afecções pulmonares exógenas, a pneumonia lipóide (PL, causada pela broncoaspiração de lipídeos, é uma doença pouco diagnosticada. Ela resulta da reacção tipo corpo estranho que se segue à presença de material lipídico dentro do parênquima pulmonar. Em geral, o agente etiológico é o óleo mineral utilizado como agente laxativo. Doentes com histórico de constipação intestinal e uso crónico de óleo mineral, com tosse e dispneia, devem ser pesquisados quanto a esta doença. Apresentamos um caso de pneumonia lipóide associada ao uso de óleo mineral como agente laxativo, acentuamos as dificuldades relacionadas com a definição diagnóstica e revemos a literatura pertinente ao tema.Rev Port Pneumol 2008; XIV (4: 545-549 Abstract: Lipoid pneumonia (LP is a pneumonitis resulting from the aspiration of lipids, and is commonly associated with the use of mineral oil as a laxative. LP is relatively unfamiliar to clinicians and is probably underdiagnosed. Making a diagnosis of LP requires a high degree of clinical suspicion. The aim of this publication are to present a case of a patient with LP and to increase physician awareness of LP, its diagnosis and prevention.Rev Port Pneumol 2008; XIV (4: 545-549 Palavras-chave: Pneumonia lipóide, óleo mineral, doenças pulmonares intersticiais, idoso, Key-words: Lipid pneumonia, mineral oil, interstitial lung diseases, aged

  6. Tumores dermóides e epidermóides intra-espinhas

    Directory of Open Access Journals (Sweden)

    Oscar Fontenelle Filho

    1971-03-01

    Full Text Available São relatados dois casos de tumores epidermóides e um de tumor dermóide, todos intrarraquianos. Este último era de localização epidural ao nível da coluna torácica (caso 3; os dois tumores epidermóides situavam-se na coluna tóraco-lombar (caso 1 e lombar (caso 2, respectivamente, sendo o primeiro intramedular e o segundo intradural. Em dois casos (casos 2 e 3 os tumores associavam-se a fístula dérmica congênita. Um paciente (caso 3 foi operado aos dois meses de idade; a descoberta do tumor deveu-se à realização da raquimanometria que revelou bloqueio, apesar do paciente não apresentar qualquer sinal neurológico de compressão medular. Os autores são de opinião que, em presença de fístula dérmica congênita ao nível da coluna vertebral, principalmente quando localizada acima do segmento lombosacro, deve-se sempre suspeitar da possibilidade do tumor epidermóide ou dermóide intrarraquiano, mesmo na ausência de sinais neurológicos. A combinação de sintomas neurológicos de longa duração, a evidência radiológica de erosão e alargamento do canal raquiano e a história de fístula dérmica congênita proporcionaram o diagnóstico pré-operatório correto no caso 2.

  7. 48 CFR 2804.506 - Exemptions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Exemptions. 2804.506 Section 2804.506 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General ADMINISTRATIVE MATTERS Electronic Commerce in Contracting 2804.506 Exemptions. Pursuant to FAR 4.506(b), all determinations that FACNET processing is not cost-effective...

  8. 24 CFR 58.34 - Exempt activities.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Exempt activities. 58.34 Section 58... Process: Documentation, Range of Activities, Project Aggregation and Classification § 58.34 Exempt activities. (a) Except for the applicable requirements of § 58.6, the responsible entity does not have to...

  9. Evaluation of total carotenoids, alpha- and beta-carotene in carrots (Daucus carota L. during home processing Avaliação de carotenóides totais, alfa e beta-caroteno em cenoura (Daucus carota L. durante processamento a nível doméstico

    Directory of Open Access Journals (Sweden)

    Helena Maria PINHEIRO-SANT’ANA

    1998-04-01

    Full Text Available This study aims to analyze the influence of dehydration and different preparation methods during home processing related toalpha-carotene, beta-carotene and total carotenoids stability in carrots. Vitamin A values were evaluated after different treatments. Thus, carrots were submitted to steam cooking, water cooking with and without pressure, moist/dry cooking and conventional dehydration. Determination of alpha- and beta-carotenes was made by High-Performance Liquid Chromatography (HPLC (conditions were developed by us using spectrophotometric detection visible-UV at 470 nm; a RP-18 column and methanol: acetonitrile: ethyl acetate (80: 10: 10 as mobile phase. Total carotenoids quantification was made by 449 nm spectrophotometer. The retention of the analyzed carotenoids ranged from 60.13 to 85.64%. Water cooking without pressure promoted higher retention levels of alpha- and beta-carotene and vitamin A values, while water cooking with pressure promoted higher retention levels of total carotenoids. Dehydration promoted the highest carotenoid losses. The results showed that, among the routinely utilized methods under domestic condition, cooking without pressure, if performed under controlled time and temperature, is the best method as it reduces losses in the amount of alpha- and beta-carotene, the main carotenoids present in the carrots. Despite the significant carotenoid losses, carrots prepared through domestic methods, remain a rich source of provitamin A.O presente estudo teve como objetivo analisar a influência da desidratação e de diferentes métodos de preparo a nível doméstico sobre a estabilidade de alfa-caroteno, beta-caroteno e carotenóides totais em cenouras. Os valores de vitamina A foram avaliados após os diferentes tratamentos. Para tanto, amostras de cenoura foram submetidas à cocção a vapor, cocção em água com e sem pressão, cocção úmida/seca e à desidratação convencional. Para a determinação de alfa e beta

  10. Cisto dermóide cerebelar

    Directory of Open Access Journals (Sweden)

    Walter Pereira

    1964-06-01

    Full Text Available Os autores relatam um caso de cisto dermóide cerebelar, único encontrado entre 513 tumores intracranianos operados de janeiro de 1945 a março de 1963, confirmando sua raridade. Tratava-se de criança que apresentava síndrome de hipertensão intracraniana e quadro cerebelar instalados dois meses antes da internação. Os exames complementares levaram ao diagnóstico provável de meduloblastoma cerebelar. Foi feita a abertura da lâmina terminal para aliviar a hipertensão intracraniana e, ulteriormente, cobaltoterapia visando a fossa poterior. Com estas medidas houve apenas discreta melhora do quadro de hipertensão intracraniana, não se alterando o quadro cerebelar. Cogitava-se da intervenção direta na fossa craniana posterior quando ocorreu osteomielite do retalho da craniotomia frontal. O osso contaminado foi retirado, seguindo-se a esta intervenção hipertermia acentuada e convulsões generalizadas, vindo a paciente a falecer. A necropsia mostrou, além de meningite purulenta, a existência de cisto dermóide cerebelar direito, contendo grande quantidade de substância sebácea e alguns pêlos. O exame histopatológico confirmou o diagnóstico microscópico, mostrando tratar-se de tecidos derivados do ectoderma e do mesoderma.

  11. Integrated titanium dioxide (TiO{sub 2}) nanoparticles on interdigitated device electrodes (IDEs) for pH analysis

    Energy Technology Data Exchange (ETDEWEB)

    Azizah, N., E-mail: norazizahparmin84@gmail.com; Gopinath, Subash C. B.; Nadzirah, Sh.; Farehanim, M. A.; Fatin, M. F.; Ruslinda, A. R. [Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP) Kangar, Perlis (Malaysia); Hashim, U., E-mail: uda@unimap.edu.my; Arshad, M. K. Md.; Ayub, R. M. [Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP) Kangar, Perlis (Malaysia); School of Microelectronic Engineering Universiti Malaysia Perlis (UniMAP) Kangar, Perlis (Malaysia)

    2016-07-06

    Titanium dioxide (TiO{sub 2}) nanoparticles based Interdigitated Device Electrodes (IDEs) Nanobiosensor device was developed for intracellular biochemical detection. Fabrication and characterization of pH sensors using IDE nanocoated with TiO{sub 2} was studied in this paper. In this paper, a preliminary assessment of this intracellular sensor with electrical measurement under different pH levels. 3-aminopropyltriethoxysilane (APTES) was used to enhance the sensitivity of titanium dioxide layer as well as able to provide surface modification by undergoing protonation and deprotonation process. Different types of pH solution provide different resistivity and conductivity towards the surface. Base solution has the higher current compared to an acid solution. Amine and oxide functionalized TiO{sub 2} based IDE exhibit pH-dependent could be understood in terms of the change in surface charge during protonation and deprotonation. The simple fabrication process, high sensitivity, and fast response of the TiO{sub 2} based IDEs facilitate their applications in a wide range of areas. The small size of semiconductor TiO{sub 2} based IDE for sensitive, label-free, real time detection of a wide range of biological species could be explored in vivo diagnostics and array-based screening.

  12. Pneumonia lipóide Lipoid pneumonia

    OpenAIRE

    Gunther Kissmann; Mauro Zamboni; Andreia Salarini Monteiro; Aureliano M Cavalcanti de Sousa; Marilene Nascimento; Mauro Esteves; Paulo de Biasi; Deborah Cordeiro Lannes

    2008-01-01

    Dentre as afecções pulmonares exógenas, a pneumonia lipóide (PL), causada pela broncoaspiração de lipídeos, é uma doença pouco diagnosticada. Ela resulta da reacção tipo corpo estranho que se segue à presença de material lipídico dentro do parênquima pulmonar. Em geral, o agente etiológico é o óleo mineral utilizado como agente laxativo. Doentes com histórico de constipação intestinal e uso crónico de óleo mineral, com tosse e dispneia, devem ser pesquisados quanto a esta doença. Apresentamos...

  13. U.S. Department of Energy FreedomCar & Vehicle Technologies Program CARB Executive Order Exemption Process for a Hydrogen-fueled Internal Combustion engine Vehicle -- Status Report

    Energy Technology Data Exchange (ETDEWEB)

    2008-04-01

    The CARB Executive Order Exemption Process for a Hydrogen-fueled Internal Combustion Engine Vehicle was undertaken to define the requirements to achieve a California Air Resource Board Executive Order for a hydrogenfueled vehicle retrofit kit. A 2005 to 2006 General Motors Company Sierra/Chevrolet Silverado 1500HD pickup was assumed to be the build-from vehicle for the retrofit kit. The emissions demonstration was determined not to pose a significant hurdle due to the non-hydrocarbon-based fuel and lean-burn operation. However, significant work was determined to be necessary for Onboard Diagnostics Level II compliance. Therefore, it is recommended that an Experimental Permit be obtained from the California Air Resource Board to license and operate the vehicles for the durability of the demonstration in support of preparing a fully compliant and certifiable package that can be submitted.

  14. Tüdruku muutunud veregrupp andis teadlastele idee / Alo Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Alo

    2008-01-01

    Austraalia tüdruk on esimene teadaolev inimene, kelle organism on muutnud veregruppi ning võtnud üle siirdatud organi immuunsüsteemi. Teadlastele andis see idee äratõukereaktsioonide vältimiseks organisiirdamistel

  15. Carcinoma mucoepidermóide de tireóide: relato de caso e revisão da literatura

    OpenAIRE

    França,Sabrina R.; Caldas,Dayse; V. Junior,Alcebíades; Oliveira,Carlos A.B. de

    2006-01-01

    O carcinoma mucoepidermóide é um tipo de neoplasia encontrada geralmente nas glândulas salivares, mamas, pâncreas e trato digestivo. O acometimento primário da glândula tireóide é muito raro, apenas 33 casos na literatura. Embora a maioria dos casos de carcinoma mucoepidermóide de tireóide (CMET) tenha evolução favorável, o caso clínico relatado descreve uma paciente com tumor agressivo e, a partir deste relato, é apresentada revisão da literatura quanto aos aspectos clínico, histopatológico,...

  16. 40 CFR 180.1159 - Pelargonic acid; exemption from the requirement of tolerances.

    Science.gov (United States)

    2010-07-01

    ..., vats, fillers, evaporators, pasteurizers and aseptic equipment in restaurants, food service operations, dairies, breweries, wineries, beverage and food processing plants. ... (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Exemptions...

  17. High-throughput oxidation screen of antibody-drug conjugates by analytical protein A chromatography following IdeS digest.

    Science.gov (United States)

    Buecheler, Jakob W; Winzer, Matthias; Weber, Christian; Gieseler, Henning

    2018-01-30

    Oxidation of protein therapeutics is a major chemical degradation pathway which may impact bioactivity, serum half-life and stability. Therefore, oxidation is a relevant parameter which has to be monitored throughout formulation development. Methods such as HIC, RPLC and LC/MS achieve a separation of oxidized and non-oxidized species by differences in hydrophobicity. Antibody-drug conjugates (ADC) although are highly more complex due to the heterogeneity in linker, drug, drug-to-antibody ratio (DAR) and conjugation site. The analytical protein A chromatography can provide a simple and fast alternative to these common methods. A miniature analytical protein A chromatography method in combination with an IdeS digest was developed to analyse ADCs. The IdeS digest efficiency of an IgG1 was monitored using SEC-HPLC and non-reducing SDS-PAGE. An antibody-fluorescent dye conjugate was conjugated at different dye-to-antibody ratios as model construct to mimic an ADC. With IdeS, an almost complete digest of a model IgG1 can be achieved (digested protein amount >98%). This enables subsequent analytical protein A chromatography, which consequently eliminates any interference of payload with the stationary phase. A novel high-throughput method for an interchain cysteine-linked ADC oxidation screens during formulation development was developed. © 2018 Royal Pharmaceutical Society.

  18. Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats.

    Science.gov (United States)

    Ismail, Norsharina; Ismail, Maznah; Azmi, Nur Hanisah; Bakar, Muhammad Firdaus Abu; Yida, Zhang; Abdullah, Maizaton Atmadini; Basri, Hamidon

    2017-11-01

    Though the causes of Alzheimer's disease (AD) are yet to be understood, much evidence has suggested that excessive amyloid-β (Aβ) accumulation due to abnormal amyloid-β precursor protein (APP) processing and Aβ metabolism are crucial processes towards AD pathogenesis. Hence, approaches aiming at APP processing and Aβ metabolism are currently being actively pursued for the management of AD. Studies suggest that high cholesterol and a high fat diet have harmful effects on cognitive function and may instigate the commencement of AD pathogenesis. Despite the neuropharmacological attributes of black cumin seed (Nigella sativa) extracts and its main active compound, thymoquinone (TQ), limited records are available in relation to AD research. Nanoemulsion (NE) is exploited as drug delivery systems due to their capacity of solubilising non-polar active compounds and is widely examined for brain targeting. Herewith, the effects of thymoquinone-rich fraction nanoemulsion (TQRFNE), thymoquinone nanoemulsion (TQNE) and their counterparts' conventional emulsion in response to high fat/cholesterol diet (HFCD)-induced rats were investigated. Particularly, the Aβ generation; APP processing, β-secretase 1 (BACE1), γ-secretases of presenilin 1 (PSEN1) and presenilin 2 (PSEN2), Aβ degradation; insulin degrading enzyme (IDE), Aβ transportation; low density lipoprotein receptor-related protein 1 (LRP1) and receptor for advanced glycation end products (RAGE) were measured in brain tissues. TQRFNE reduced the brain Aβ fragment length 1-40 and 1-42 (Aβ40 and Aβ42) levels, which would attenuate the AD pathogenesis. This reduction could be due to the modulation of β- and γ-secretase enzyme activity, and the Aβ degradation and transportation in/out of the brain. The findings show the mechanistic actions of TQRFNE in response to high fat and high cholesterol diet associated to Aβ generation, degradation and transportation in the rat's brain tissue. Copyright © 2017 Elsevier

  19. 40 CFR 94.906 - Manufacturer-owned exemption, display exemption, and competition exemption.

    Science.gov (United States)

    2010-07-01

    ... corporate name and trademark of manufacturer; (C) Engine displacement, engine family identification, and... ENGINES Exclusion and Exemption Provisions § 94.906 Manufacturer-owned exemption, display exemption, and competition exemption. (a) Manufacturer-owned exemption. Any manufacturer-owned engine, as defined by § 94.2...

  20. Towards Enabling Overture as a Platform for Formal Notation IDEs

    Directory of Open Access Journals (Sweden)

    Luís Diogo Couto

    2015-08-01

    Full Text Available Formal Methods tools will never have as many users as tools for popular programming languages and so the effort spent on constructing Integrated Development Environments (IDEs will be orders of magnitudes lower than that of programming languages such as Java. This means newcomers to formal methods do not get the same user experience as with their favourite programming IDE. In order to improve this situation it is essential that efforts are combined so it is possible to reuse common features and thus not start from scratch every time. This paper presents the Overture platform where such a reuse philosophy is present. We give an overview of the platform itself as well as the extensibility principles that enable much of the reuse. The paper also contains several examples platform extensions, both in the form of new features and a new IDE supporting a new language.

  1. Concordant association of insulin degrading enzyme gene (IDE variants with IDE mRNA, Abeta, and Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Minerva M Carrasquillo

    2010-01-01

    Full Text Available The insulin-degrading enzyme gene (IDE is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD.We examined conserved regions of IDE and its 10 kb flanks in 269 AD cases and 252 controls thereby identifying 17 putative functional polymorphisms. These variants formed eleven haplotypes that were tagged with ten variants. Four of these showed significant association with IDE transcript levels in samples from 194 LOAD cerebella. The strongest, rs6583817, which has not previously been reported, showed unequivocal association (p = 1.5x10(-8, fold-increase = 2.12,; the eleven haplotypes were also significantly associated with transcript levels (global p = 0.003. Using an in vitro dual luciferase reporter assay, we found that rs6583817 increases reporter gene expression in Be(2-C (p = 0.006 and HepG2 (p = 0.02 cell lines. Furthermore, using data from a recent genome-wide association study of two Croatian isolated populations (n = 1,879, we identified a proxy for rs6583817 that associated significantly with decreased plasma Abeta40 levels (ss = -0.124, p = 0.011 and total measured plasma Abeta levels (b = -0.130, p = 0.009. Finally, rs6583817 was associated with decreased risk of LOAD in 3,891 AD cases and 3,605 controls. (OR = 0.87, p = 0.03, and the eleven IDE haplotypes (global p = 0.02 also showed significant association.Thus, a previously unreported variant unequivocally associated with increased IDE expression was also associated with reduced plasma Abeta40 and decreased LOAD susceptibility. Genetic association between LOAD and IDE has been difficult to replicate. Our findings suggest that targeted testing of expression SNPs (eSNPs strongly associated with altered transcript levels in autopsy brain samples may be a powerful way to identify genetic associations with LOAD that would otherwise be difficult to detect.

  2. Therapeutic use exemption

    Science.gov (United States)

    Dvorak, J; Kirkendall, D; Vouillamoz, M

    2006-01-01

    Football players who have either physical symptoms or disease after injury may need to be treated with specific medicines that are on the list of prohibited substances. Therapeutic use exemption may be granted to such players, in accordance with strictly defined criteria—these are presented in this article. Procedures of how to request for an abbreviated or a standard therapeutic use exemption are explained, and data on therapeutic use exemptions (UEFA and FIFA, 2004 and 2005) are also presented. PMID:16799102

  3. Riiklik venekeelne ajaleht: venelased laidavad ideed / Mirko Ojakivi, Hetlin Villak

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2009-01-01

    Narvskaja Gazeta peatoimetaja Sergei Stepanov ja Den za Dnjomi tegevtoimetaja Jevgenia Garanža suhtuvad skeptiliselt siseminister Marko Pomerantsi ideesse hakata Ida-Virumaal välja andma riiklikku venekeelset ajalehte. BNS-i juhatuse liikme Anvar Samosti, TÜ emeriitprofessori Marju Lauristini arvamusi ja hinnanguid idee kohta

  4. Structural characterization of expressed monoclonal antibodies by single sample mass spectral analysis after IdeS proteolysis.

    Science.gov (United States)

    Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B

    2016-08-26

    Simple and rapid methods for analysis of monoclonal antibody structure and post-translational modifications are increasingly needed due to the explosion of therapeutic monoclonal antibodies and monoclonal antibody applications. Mass spectral analysis is a powerful method for characterizing monoclonal antibodies. Recent discovery and commercialization of the Immunoglobulin G-degrading enzyme of Streptococcus pyogene (IdeS protease) has facilitated and improved the generation of antibody fragments of suitable size to allow characterization of the structure of the entire antibody molecule via analysis of just a few fragments. In this study, we coupled IdeS fragmentation and simultaneous reduction and alkylation of the resultant fragments using tributylphosphine and iodoacetamide to prepare samples in about 2 h. Following simple introduction of a single, unseparated mixture of alkylated fragments into a mass spectrometer, detailed structural information is obtained, covering the entire antibody molecule. The large majority of the glycoforms present on the single, conserved N-linked glycosylation site of the heavy chain is elucidated, although some of the very low abundance glycoforms are not determined by this protocol. The ease, simplicity, speed, and power of this method make it attractive for analysis of the developmental stages and production batches of therapeutic monoclonal antibodies. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. 7 CFR 1215.300 - Exemption procedures.

    Science.gov (United States)

    2010-01-01

    ... organic handling operation certificate provided by a USDA-accredited certifying agent as defined in..., on a form provided by the Board, for a certificate of exemption. Such processor shall certify that...) Persons that process solely 100 percent organic products and that do not process any conventional or...

  6. DETERMINING KEY COMPETENCIES AS A STARTING BASE OF THE COMPETENCE MODEL IN THE PROCESS OF SOCIAL ADAPTATION OF EXEMPTED MILITARIES FROM BULGARIAN ARMY

    Directory of Open Access Journals (Sweden)

    Venelin Terziev

    2014-09-01

    Full Text Available Scientific study in the paper is directed towards determining key competences of exempted militaries from Bulgarian army and substantiating of a mathematical competence model for making estimations of those competences, and creation of a theoretical and practical algorithm for the application of the model.

  7. SPEEDY: An Eclipse-based IDE for invariant inference

    Directory of Open Access Journals (Sweden)

    David R. Cok

    2014-04-01

    Full Text Available SPEEDY is an Eclipse-based IDE for exploring techniques that assist users in generating correct specifications, particularly including invariant inference algorithms and tools. It integrates with several back-end tools that propose invariants and will incorporate published algorithms for inferring object and loop invariants. Though the architecture is language-neutral, current SPEEDY targets C programs. Building and using SPEEDY has confirmed earlier experience demonstrating the importance of showing and editing specifications in the IDEs that developers customarily use, automating as much of the production and checking of specifications as possible, and showing counterexample information directly in the source code editing environment. As in previous work, automation of specification checking is provided by back-end SMT solvers. However, reducing the effort demanded of software developers using formal methods also requires a GUI design that guides users in writing, reviewing, and correcting specifications and automates specification inference.

  8. Tumor Filóides Borderline: Relato de caso

    Directory of Open Access Journals (Sweden)

    MARINA PIRASSOL TEPEDINO

    2016-12-01

    Full Text Available O presente artigo tem o objetivo de narrar o caso de uma jovem de 24 anos, que teve quadro de Tumor Filóides do tipo borderline, evidenciado durante cirurgia de excisão de fibroadenoma, e diagnosticado por exame histopatológico da lesão, sendo futuramente reabordado com nova cirurgia. O Tumor Filóides é uma neoplasia fibroepitelial incomum da mama, representando de 0,3 a 0,9% de todos os tumores primários daquele órgão. É comumente vista entre pacientes com 40-50 anos. Sendo mais raro ainda sua apresentação em jovens. Por fim este artigo apresenta breve revisão de literatura, mostrando que a conduta utilizada no caso foi correta.

  9. 77 FR 59245 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-09-26

    ... Application of Multiple Regression Analysis of a Poisson Process,'' Journal of American Statistical... applications, FMCSA exempts Michael J. Bechta (PA), Bryan G. Brockus (ID), Larry Clay NM), Michael D. DeKorte...

  10. Study of concentration of HPV DNA probe immobilization for cervical cancer detection based IDE biosensor

    Science.gov (United States)

    Roshila, M. L.; Hashim, U.; Azizah, N.

    2016-07-01

    This paper mainly illustrates regarding the detection process of Human Papillomavirus (HPV) DNA probe. HPV is the most common virus that infected to human by a sexually transmitted virus. The most common high-risk HPV are 16 and 18. Interdigitated electrode (IDE) device used as based of Titanium Dioxide (TiO2) acts as inorganic surface, where by using APTES as a linker between inorganic surface and organic surface. A strategy of rapid and sensitive for the HPV detection was proposed by integrating simple DNA extraction with a gene of DNA. The extraction of the gene of DNA will make an efficiency of the detection process. It will depend on the sequence of the capture probes and the way to support their attached. The fabrication, surface modification, immobilization and hybridization processes are characterized by current voltage (I-V) measurement by using KEITHLEY 6487. This strategy will perform a good sensitivity of HPV detection.

  11. 24 CFR 16.15 - Specific exemptions.

    Science.gov (United States)

    2010-04-01

    ... release of an accounting of disclosures to an individual who may be the subject of an investigation could..., who are the subjects of investigation, from frustrating the investigatory process, to ensure the.... Investigation Files in the Office of the Inspector General. (3) HUD/DEPT-25. Legal Action Files. (b) Exempt...

  12. 9 CFR 590.100 - Specific exemptions.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Specific exemptions. 590.100 Section 590.100 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG... employees; (f) (g) The processing in nonofficial plants, including but not limited to bakeries, restaurants...

  13. 7 CFR 57.100 - Specific exemptions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Specific exemptions. 57.100 Section 57.100 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... processing in nonofficial plants, including but not limited to bakeries, restaurants, and other food...

  14. Imaging X-ray detector front-end with high dynamic range: IDeF-X HD

    Science.gov (United States)

    Gevin, O.; Lemaire, O.; Lugiez, F.; Michalowska, A.; Baron, P.; Limousin, O.; Delagnes, E.

    2012-12-01

    Presented circuit, IDeF-X HD (Imaging Detector Front-end) is a member of the IDeF-X ASICs family for space applications. It has been optimized for a half millimeter pitch CdTe or CdZnTe pixelated detector arranged in 16×16 array. It is aimed to operate in the hard X-ray range from few keV up to 250 keV or more. The ASIC has been realized in AMS 0.35 μm CMOS process. The IDeF-X HD is a 32 channel analog front-end with self-triggering capability. The architecture of the analog channel includes a chain of charge sensitive amplifier with continuous reset system and non-stationary noise suppressor, adjustable gain stage, pole-zero cancellation stage, adjustable shaping time low pass filter, baseline holder and peak detector with discriminator. The power consumption of the IDeF-X HD is 800 μW per channel. With the in-channel variable gain stage the nominal 250 keV dynamic range of the ASIC can be extended up to 1 MeV anticipating future applications using thick sensors. Measuring the noise performance without a detector at the input with minimized leakage current (programmable) at the input, we achieved ENC of 33 electrons rms at 10.7 μs peak time. Measurements with CdTe detector show good energy resolution FWHM of 1.1 keV at 60 keV and 4.3 keV at 662 keV with detection threshold below 4 keV. In addition, an absolute temperature sensor has been integrated with resolution of 1.5 °C.

  15. Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity

    Science.gov (United States)

    Winstedt, Lena; Järnum, Sofia; Nordahl, Emma Andersson; Olsson, Andreas; Runström, Anna; Bockermann, Robert; Karlsson, Christofer; Malmström, Johan; Palmgren, Gabriella Samuelsson; Malmqvist, Ulf; Björck, Lars; Kjellman, Christian

    2015-01-01

    IdeS is a streptococcal protease that cleaves IgG antibodies into F(ab’)2 and Fc fragments with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG-driven autoimmune conditions and antibody mediated transplant rejection. Here we report the results from a first in man, double blinded and randomized study with single ascending doses of IdeS in healthy, male subjects. Twenty healthy subjects were given intravenous single ascending doses of IdeS. With impressive efficacy IdeS cleaved the entire plasma IgG-pool only minutes after dosing. IgG reached nadir 6-24 hours after dosing and then slowly recovered. The half-life of IdeS was 4.9 (±2.8) hours at 0.24 mg/kg with the main fraction eliminated during 24 hours. Already two hours after IdeS-dosing, the phagocytic capacity of IgG/IgG-fragments was reduced to background levels. Importantly, IdeS has the capacity to inactivate Fc-mediated effector function in vivo, was considered safe with no serious adverse events, and without dose limiting toxicity in this study. The complete, rapid, but temporary removal of IgG provides a new potent therapeutic opportunity in IgG-mediated pathogenic conditions. Trial Registration ClinicalTrials.gov NCT01802697 PMID:26177518

  16. Tratamento de leucemia linfóide aguda e crescimento

    OpenAIRE

    Monteiro I.M.U.; Bedone A.J.; Pinto C.L.B.; Brandalise S.R.

    1998-01-01

    OBJETIVO: Determinar alterações no crescimento após o tratamento de leucemia linfóide aguda em meninas. PACIENTES E MÉTODO: Realizou-se estudo retrospectivo com 59 meninas que apresentavam medidas de estatura antes e com no mínimo um ano do tratamento, subdivididas de acordo com a dose de radioterapia cranial utilizada [18 ou 24 Grays (Gy)] e com a idade no início do tratamento (antes e após os cinco anos de idade). RESULTADOS: Observou-se deficiência do crescimento com um, dois e mais de doi...

  17. Accelerating the creation of customized, language-specific IDEs in Eclipse

    NARCIS (Netherlands)

    P. Charles; R.M. Fuhrer; S.M. Sutton; E. Duesterwald; J.J. Vinju (Jurgen); G.T. Leavens

    2009-01-01

    textabstractFull-featured integrated development environments have become critical to the adoption of new programming languages. Key to the success of these IDEs is the provision of services tailored to the languages. However, modern IDEs are large and complex, and the cost of constructing one from

  18. IdeMatch – a digital tool for innovative, social and transdisciplinary learning designs

    DEFF Research Database (Denmark)

    Hansen, Gitte Riis

    This paper presents IdeMatch which is a digital tool implemented in University College Zealand (UCZ) in spring 2015. IdeMatch is based on educational policies and educational structural intentions and needs, and this paper examines and offers an outline for the learning perspective and the impact...

  19. Resignation from the VAT exemption of sales of residential premises by the developer

    Directory of Open Access Journals (Sweden)

    Joanna Koziollek

    2016-09-01

    Full Text Available Tax institutions should be construed in a rational manner, in order so as to not restrict economic turnover excessively. The regulations concerning the possibility to resign from the VAT exemption of sales of residential premises by the developer characterizes by the high level of formalism which affects in a negative manner the sales process performed by the developer. This paper is devoted to the fragment of the polish Act on the goods and services tax governing the issue of resignation from the VAT exemption of sales of residential premises, which implies in a certain extent to appeal to the regulation of exemptions stipulated in this Act. The subject matter of this analysis is to examine the correctness of transposition of the Directive 112 into polish legal system in the field of real estate exemptions from VAT, the conditions for exercising the optional exemption, as well as the benefit of the resignation from the VAT exemption by the taxpayer.

  20. Il dito di Galileo le dieci grandi idee della scienza

    CERN Document Server

    Atkins, Peter

    2004-01-01

    Domande e risposte per dieci idee che hanno plasmato il mondo di oggi. Possiamo rintracciare l'origine e il divenire del cosmo? Perché spazio e tempo formano una cosa sola? Che cosa significa l'evoluzione del vivente? Perché il DNA è così importante? Perché il mondo ha bisogno di energia? E com'è che l'aumento dell'entropia scandisce il cambiamento dell'intero universo? Cosa sono gli atomi e cosa c'è di più piccolo di essi? Perché la simmetria della natura e dell'arte cattura il nostro senso della bellezza? Cosa sono quegli elusivi quanti alla base della fisica contemporanea? Siamo sicuri che l'aritmetica non ci inganni? Peter Atkins offre una guida chiara e completa all'impresa scientifica, seguendo la via indicata dal dito di Galileo.

  1. Diagnostico laboratorial das leucemias mielóides agudas

    OpenAIRE

    Silva,Graziele C. da; Pilger, Diogo Andre; Castro,Simone Martins de; Wagner,Sandrine Comparsi

    2006-01-01

    As leucemias agudas caracterizam-se pela proliferação clonal e pelo bloqueio maturativo das células hematopoéticas, com substituição difusa da medula óssea por células neoplásicas. A leucemia mielóide aguda (LMA) é um grupo heterogêneo de doenças clonais do tecido hematopoético, que acomete predominantemente idosos acima de 60 anos de idade. A LMA apresenta oito subtipos distintos morfologicamente: LMA M0 a M7. Os métodos diagnósticos para identificação da LMA e classificação dos subtipos são...

  2. FoCaLiZe: Inside an F-IDE

    Directory of Open Access Journals (Sweden)

    François Pessaux

    2014-04-01

    Full Text Available For years, Integrated Development Environments have demonstrated their usefulness in order to ease the development of software. High-level security or safety systems require proofs of compliance to standards, based on analyses such as code review and, increasingly nowadays, formal proofs of conformance to specifications. This implies mixing computational and logical aspects all along the development, which naturally raises the need for a notion of Formal IDE. This paper examines the FoCaLiZe environment and explores the implementation issues raised by the decision to provide a single language to express specification properties, source code and machine-checked proofs while allowing incremental development and code reusability. Such features create strong dependencies between functions, properties and proofs, and impose an particular compilation scheme, which is described here. The compilation results are runnable OCaml code and a checkable Coq term. All these points are illustrated through a running example.

  3. Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease.

    Science.gov (United States)

    Haque, Rizwanul; Nazir, Aamir

    2016-11-01

    Insulin-degrading enzyme (IDE) is a zinc metalloprotease, known to degrade insulin peptide and amyloid-beta (Aβ); the key protein involved in Alzheimer's disease (AD). Considering the important role played by IDE in disease progression of AD and type 2 diabetes mellitus (T2DM), we endeavored to identify the Caenorhabditis elegans (C. elegans) IDE orthologous genes and test them for their role in AD related outcomes. We employed bioinformatics, reverse genetics and molecular biology approaches towards identification and functional characterization of putative IDE candidates in C. elegans. Using in-silico analysis we have identified seven C. elegans genes that possess HXXEH motif, an identifying marker of IDE. We further carried out functional analysis of the identified genes in Aβ expressing C. elegans strain CL4176 [myo-3/Aβ1-42 long 3'-UTR] via studying effect on Aβ induced toxicity, cholinergic neuroanatomy, content of acetylcholine/acetylcholine-esterase, extent of reactive oxygen species and expression of FOXO transcription factor DAF-16. Our findings reveal that amongst the identified putative IDE orthologs, a functionally uncharacterized gene C28F5.4 had a profound effect on the tested endpoints. Knocking down C28F5.4 modulated the AD associated conditions by decreasing Aβ induced toxicity, severely compromising cholinergic neuroanatomy, reducing expression of acetylcholine-transporter, decreasing acetylcholine content, elevating ROS, with no effect on DAF-16 stress-response protein. These studies provide crucial insight into the structural/functional orthology of IDEs across human and nematode species and further our understanding of the involvement of these proteins and insulin pathway in AD. Further studies could aid in identifying novel drug-targets and in understanding the common modulating factors between AD and T2DM. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Increasing Diversity in the Earth Sciences (IDES) - An Oregon Effort

    Science.gov (United States)

    de Silva, S. L.; Duncan, R. A.; Wright, D. J.; de Silva, L.; Guerrero, E. F.

    2011-12-01

    The IDES (Increasing Diversity in Earth Sciences) Program is the first partnership of its kind in the state of Oregon targeted at broadening participation in the Earth Science enterprise. Funded by the National Science Foundation Opportunities to Enhance Diversity in the Geosciences program (NSF-OEDG), this partnership involves community colleges, a research university with major strengths in Earth Science research and education and an institutionalized commitment to enhancing diversity, state and federal agencies, centers of informal education, and the Oregon Space Grant Consortium, IDES has two integrated goals: 1) to increase the number of students from under-represented groups who pursue careers in Earth Science research and education, and 2) to strengthen the understanding of Earth Sciences and their relevance to society among broad and diverse segments of the population. Built around the best practices of tiered mentoring, interactive student cohort, research and education internships, and financial support, this 4-year program recruits 10 to 12 students (mainly rising juniors) each year from science majors at Oregon State University and five Oregon community colleges. The program is reaching its goals by: a) training participants in the application of geospatial to Earth Science problems of personal relevance b) immersing participants in a two-year mentored research project that involves summer internships with academic units, state and federal agencies, and centers for informal education in Oregon. c) exposing, educating, and involving participants in the breadth of Earth Science careers through contact with Earth Science professionals through mentors, a professional internship, and a learning community that includes a speaker series. d) instilling an understanding of context and relevance of the Earth Science Enterprise to the participants, their families, their communities, and the general public. We report on the first two years of this program during

  5. Bases anatómicas da cirurgia da glândula tiróide

    OpenAIRE

    Melo, Catarina José Monteiro Campos de

    2011-01-01

    Trabalho final de mestrado integrado em Medicina área cientifica de Anatomia, apresentado á Faculdade de Medicina da Universidade de Coimbra Introdução: É indispensável ter um conhecimento profundo da Morfologia da glândula tiróide, para minimizar a incidência de complicações suscitadas pela tiroidectomia, nomeadamente a lesão das glândulas paratiróides e dos nervos laríngeos. Objectivos: Revisão teórica sobre a Anatomia normal da glândula tiróide e das estruturas com ela relacionadas d...

  6. 29 CFR 2570.37 - Duty to amend and supplement exemption applications.

    Science.gov (United States)

    2010-07-01

    ... party in interest who would participate in the exemption transaction becomes the subject of an....37 Section 2570.37 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY... Filing and Processing Prohibited Transaction Exemption Applications § 2570.37 Duty to amend and...

  7. 19 CFR 54.5 - Scope of exemptions; nondeposit of estimated duty.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Scope of exemptions; nondeposit of estimated duty...; DEPARTMENT OF THE TREASURY CERTAIN IMPORTATIONS TEMPORARILY FREE OF DUTY Metal Articles Imported to Be Used... Processing Which Renders Them Fit Only for the Recovery of the Metal Content § 54.5 Scope of exemptions...

  8. 29 CFR 780.405 - Exemption is direct and does not mean activities are agriculture.

    Science.gov (United States)

    2010-07-01

    ... agriculture. 780.405 Section 780.405 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... EXEMPTIONS APPLICABLE TO AGRICULTURE, PROCESSING OF AGRICULTURAL COMMODITIES, AND RELATED SUBJECTS UNDER THE FAIR LABOR STANDARDS ACT Employment in Agriculture or Irrigation That Is Exempted From the Overtime Pay...

  9. 18 CFR 420.43 - Exempt use.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Exempt use. 420.43... MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Charges; Exemptions § 420.43 Exempt use. The following uses shall be exempt from charge: (a) Non-consumptive uses of less than 1,000 gallons during any day, and...

  10. Tallinna idee / Andres Alver, Ott Alver, Marten Kaevats ; intervjueerinud Margit Mutso ; kommenteerinud Douglas Gordon

    Index Scriptorium Estoniae

    Alver, Andres, 1953-

    2011-01-01

    17. veebruaril esitleti raamatut "Tallinna idee", mis on koostatud Eesti Kunstiakadeemia 4. kursuse arhitektuuritudengite kursuseprojektide põhjal. Tallinna teemal vestlevad tudengid Ott Alver ja Marten Kaevats ning nende juhendaja professor Andres Alver

  11. Flavonóides: potencial terapêutico no estresse oxidativo

    Directory of Open Access Journals (Sweden)

    W. C. Dornas

    2009-01-01

    Full Text Available

    Flavonóides pertencem a uma classe de compostos polifenólicos produzidos por plantas a partir da via dos fenilpropanóides. Embora possuam atividades benéficas, suas aplicações como suplemento dietético é vista com precaução, já que, participam de vários processos no organismo. Nessa revisão foram avaliados os flavonóides, suas classes, seus efeitos em doenças crônico-degenerativas, uma vez que, o interesse por eles tem aumentado pelas suas propriedades em combater radicais livres. Palavras-chave: flavonóides; polifenóis; radical livre; estresse oxidativo.

  12. Study of surface functionalization on IDE by using 3-aminopropyl triethoxysilane (APTES) for cervical cancer detection

    Science.gov (United States)

    Raqeema, S.; Hashim, U.; Azizah, N.

    2016-07-01

    This paper presented the study of surface functionalization on IDE by using 3-Aminopropyl triethoxysilane (APTES). The DNA nanochip based interdigitated (IDE) has been proposed to optimized the sensitivity of the device due to the cervical cancer detection. The DNA nanochip will be more efficient using surface modification of TiO2 nanoparticles with 3-Aminopropyl triethoxysilane (APTES). Furthermore, APTES gain the better functionalization of the adsorption mechanism on IDE. The combination of the DNA probe and the HPV target will produce more sensitivity and speed of the DNA nanochip due to their properties. The IDE has been characterized using current-voltage (IV) measurement. This functionalization of the surface would be applicable, sensitive, selective and low cost for cervical cancer detection.

  13. PM/IDE - An Integrated Development Environment for Planning Models Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a planning model integrated development environment (PM/IDE) that will help people construct, review, understand, test, and debug high-quality...

  14. Erisipelóide de Baker-Rosenbach

    Directory of Open Access Journals (Sweden)

    Aureo Guimarães de Macedo

    1970-10-01

    Full Text Available O erisipelóide de Baker-Rosenbach, embora assinalado no Brasil há 23, anos, por Sebastião Sampaio, seguido de nove casos estudados em 1951 por Lacaz e Ancona Lopes, não tem sido motivo de publicações posteriores. O A. teve ocasião de estudar seis casos, senão que três foram motivo de trabalho anterior e foram observados em 1953. Os três restantes, um de 1965 e dois de 1967, são aqui relatados. Assinala o A. a ubiquidade do germe, o Erysipelotrix rhusiopathiae e a variedade de condições em que o homem pode infectar-se, especialmente no exercício de determinadas profissões, o que dá à doença, caráter típico de doença profissional. São os operários de fábricas de botões ou em geral os que lidam com ossos, especialmente de porco ou carneiro, os açougueiros, magarefes, salsicheiros etc. São particularmente vulneráveis os que tratam com produtos do mar, pescadores, mercadores de siris, camarões, crustáceos, peixes em geral, pela facilidade com que se podem ferir e adquirir a infecção por picada ocasional. A doença atinge numerosos animais domésticos ou não, com formas clínicas bem definidas no porco (erisipela dos porcos, no carneiro (poliartrite dos carneiros, em animais de corte e de tração, em aves domésticas ou de rapina, ratos e camundongos, além de outros numerosos roedores. Moscas hematófagas e outros insetos têm sido encontrados infectados. Nunca é demais frisar que os produtos do mar são grande fonte de infecção humana. No homem, tem a dcença em geral, caráter benigno e localizado (erisipelóide, podendo em certas circunstâncias assumir característica septicêmica como no porco, produzir endocardite, como no carneiro além de outras formas clínicas e complicações. São resumidos no texto os três casos anteriormente apresentados e bem descritos os três inéditos, que têm história clínica e evolução típicas de erisipelóide. Tratando-se de doença com características tipicamente

  15. Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer’s disease

    Science.gov (United States)

    Dorfman, Verónica Berta; Pasquini, Laura; Riudavets, Miguel; López-Costa, Juan José; Villegas, Andrés; Troncoso, Juan Carlos; Lopera, Francisco; Castaño, Eduardo Miguel; Morelli, Laura

    2011-01-01

    Alzheimer’s disease (AD) is characterized by amyloid β (Aβ) accumulation in the brain and is classified as familial early-onset (FAD) or sporadic late-onset (SAD). Evidences suggest that deficits in the brain expression of insulin degrading enzyme (IDE) and neprilysin (NEP), both proteases involved in amyloid degradation, may promote Aβ deposition in SAD. We studied by immunohistochemistry IDE and NEP cortical expression in SAD and FAD samples carrying the E280A presenilin-1 missense mutation. We showed that IDE, a soluble peptidase, is linked with aggregated Aβ40 isoform while NEP, a membrane-bound protease, negatively correlates with amyloid angiopathy and its expression in the senile plaques is independent of aggregated amyloid and restricted to SAD cases. NEP, but not IDE, is over-expressed in dystrophic neurites, both proteases are immunoreactive in activated astrocytes but not in microglia and IDE was the only one detected in astrocytes of white matter from FAD cases. Collectively, our results support the notion that gross conformational changes involved in the modification from “natively folded-active” to “aggregated-inactive” IDE and NEP may be a relevant pathogenic mechanism in SAD. PMID:19019493

  16. IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type

    Directory of Open Access Journals (Sweden)

    Noriko Sato

    2008-01-01

    Full Text Available Insulin degrading enzyme (IDE degrades amyloid (A, which may inhibit the accumulation of A in a brain affected with dementia of Alzheimer's type (DAT. A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD. IDE gene polymorphism is unlikely to play a substantial role in conferring susceptibility to DAT, but it may be involved in the development of affective disturbance through the course of mild DAT, regardless of the presence of an ApoE 4 allele. The present data could be the result of a small sample size. Further investigations using larger samples are thus required to clarify the correlation between IDE gene polymorphism, susceptibility to DAT, and emergence of BPSD.

  17. 40 CFR 790.80 - Submission of exemption applications.

    Science.gov (United States)

    2010-07-01

    ... SUBSTANCES CONTROL ACT (CONTINUED) PROCEDURES GOVERNING TESTING CONSENT AGREEMENTS AND TEST RULES Exemptions... circumstances: (i) If testing is being required to allow evaluation of risks associated with manufacturing and... the date manufacture or processing begins by any person not manufacturing or processing the subject...

  18. Estableciendo una plataforma de acción y difusión: Primeros pasos del Portal Observatorio IDE

    OpenAIRE

    Moya Honduvilla, Javier; Vivas White, Pedro; Bernabe Poveda, Miguel Angel

    2008-01-01

    Considerando de gran importancia la misión del Subgrupo de Trabajo Observatorio IDE (OBsIDE) con respecto a la divulgación y difusión del paradigma IDE, el Instituto Geográfico Nacional (IGN) y el Laboratorio de Tecnologías de la Información Geográfica (LatinGEO) de la Universidad Politécnica de Madrid (UPM) han establecido una serie de acuerdos encaminados a idear diferentes estrategias de formación y difusión de las Infraestructuras de Datos Espaciales (IDE). Los escenarios y grupos de inte...

  19. 78 FR 35937 - Food and Drug Administration Decisions for Investigational Device Exemption Clinical...

    Science.gov (United States)

    2013-06-14

    ... investigations to evaluate medical devices under FDA's IDE regulations. The guidance was also intended to provide... substitute for the Pre- Submission process (Refer to the draft guidance entitled ``Medical Devices: The Pre-Submission Program and Meetings with FDA Staff'' ( http://www.fda.gov/MedicalDevices/DeviceRegulationand...

  20. Curdlan: an important microbial hydrocolloid/ Goma curdlana: um importante hidrocolóide microbiano

    Directory of Open Access Journals (Sweden)

    Elaine Soares Amorim

    2003-05-01

    Full Text Available The use of gums in the food industry is mainly based in its functional properties, which are related to the capacity to prevent or delay a series of physicals phenomenon, having an important role in the stability of many industrialized food. The use of these in the several food productions is indispensable, because they contribute to thickening, gelling, stabilization, suspension, film formation and gums can act as auxiliary agents of processing. Therefore, our objective was evaluated the chemistries physical properties, as well as, the areas of application of the microbial hydrocolloid, curdlan.O uso das gomas na indústria de alimentos baseia-se principalmente no aproveitamento de suas propriedades funcionais, que estão relacionadas à capacidade de prevenir ou retardar uma série de fenômenos físicos, desempenhando papel importante na estabilidade de muitos alimentos industrializados. É indispensável o uso destas na produção de diversos produtos alimentícios, pois contribuem para o espessamento, gelificação, estabilização, suspensão, formação de filme e podem atuar como agentes auxiliares de processamento. Desta forma, o presente trabalho buscou avaliar as propriedades físico-químicas, bem como, as áreas de aplicação da goma curdlana que é um hidrocolóide de origem microbiana.

  1. 40 CFR 180.1225 - Decanoic acid; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ..., fillers, evaporators, pasteurizers and aseptic equipment in restaurants, food service operations, dairies, breweries, wineries, beverage and food processing plants. ... AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD...

  2. 40 CFR 180.1196 - Peroxyacetic acid; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... handling establishments including, but not limited to dairies, dairy barns, restaurants, food service operations, breweries, wineries, and beverage and food processing plants. ... AGENCY (CONTINUED) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD...

  3. 21 CFR 701.9 - Exemptions from labeling requirements.

    Science.gov (United States)

    2010-04-01

    ... or delivery of such cosmetic from such establishment, and shall make such copies available for... such cosmetic is to be processed, labeled, or repacked, to make available for inspection a copy of the... (CONTINUED) COSMETICS COSMETIC LABELING General Provisions § 701.9 Exemptions from labeling requirements. (a...

  4. 40 CFR 80.1141 - Small refinery exemption.

    Science.gov (United States)

    2010-07-01

    ... parties under this subpart if that refinery meets the definition of a small refinery under § 80.1101(g... crude oil, or feedstocks derived from crude oil, through refinery processing units. (b)(1) The small... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Small refinery exemption. 80.1141...

  5. Interdigitated electrode (IDE) for porcine detection based on titanium dioxide (TiO2) thin films

    Science.gov (United States)

    Nordin, N.; Hashim, U.; Azizah, N.

    2016-07-01

    Interdigited Electrode (IDE) porcine detection can be accomplished to authenticate the halal issue that has been a concern to Muslim not only in Malaysia but all around the world. The method used is photolithography that used the p-type photoresist on the spin coater with 2500 rpm. Bare IDEs device is deposited with Titanium Dioxide (TiO2) to improve the performance of the device. The result indicates that current-voltage (I-V) measurement of porcine probe line slightly above porcine target due to negative charges repelled each other. The IDE device can detect the porcine presence in food as lowest as 1.0 µM. Better performance of the device can be achieved with the replacement of gold deposited to trigger more sensitivity of the device.

  6. 21 CFR 1308.35 - Exemption of certain cannabis plant material, and products made therefrom, that contain...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Exemption of certain cannabis plant material, and... ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE SCHEDULES OF CONTROLLED SUBSTANCES Exempt Cannabis Plant... cannabis plant material, and products made therefrom, that contain tetrahydrocannabinols. (a) Any processed...

  7. 12 CFR 233.4 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... FUNDING OF UNLAWFUL INTERNET GAMBLING (REGULATION GG) § 233.4 Exemptions. (a) Automated clearing house... are exempt from this regulation's requirements for establishing written policies and procedures... from this regulation's requirements for establishing written policies and procedures reasonably...

  8. Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

    OpenAIRE

    Pasetto,Gabriela Soncini; Freitas,Henrique Pedroso de; Colossi,Carina Graziottin; Vilela,Manuel Augusto Pereira

    2013-01-01

    OBJETIVO: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. MÉTODOS: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. RESULTADOS: De um total de 18 olhos, 7 (38.9%) foram incluídos no estudo. ...

  9. Andocanabinóides: aplicações terapêuticas

    OpenAIRE

    Fernandes, Ana Luísa Nunes Vieira

    2014-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz As propriedades dos numerosos compostos da planta Canabis sativa L., comummente conhecida por canabis ou marijuana, têm sido ao longo das últimas décadas extensamente estudadas. A descoberta de receptores para os canabinóides e dos endocanabinóides, sendo os principais a anandamida e 2-araquidonil-glicerol, sugeriu que estas moléculas poderiam ser importantes na fisiologia humana. Verifi...

  10. Carcinoma bilateral do plexo coróide operado com sucesso

    Directory of Open Access Journals (Sweden)

    Gilberto M. de Almeida

    1970-06-01

    Full Text Available Os autores não encontraram na literatura caso de carcinoma bilateral do plexo coróide operado com sucesso. O trabalho consta da apresentação de uma criança de 11 anos com carcinoma dos plexos coróides nos dois ventrículos laterais. São feitas considerações a respeito das dificuldades no diagnóstico, da importância dó estudo angiográfico completo e do tratamento

  11. Angiopatia amilóide cerebral simulando tumor cerebral: relato de caso

    OpenAIRE

    Andrade Gustavo Cardoso de; Silveira Roberto Leal; Pinheiro Jr. Nilson; Rocha Eckstânio Marcos Melo; Pittella José Eymard Homem

    2006-01-01

    Descrevemos o raro caso de um paciente de 45 anos portador de lesão expansiva intracraniana por angiopatia amilóide cerebral com características clínicas e de imagem compatíveis com um glioma de baixo grau. A biópsia revelou angiopatia amilóide cerebral. Os achados clínicos, radiológicos e histopatológicos são discutidos e analisados juntamente à literatura disponível.We describe the unusual case of a 45-year-old male patient harboring an intracranial mass due to cerebral amyloid angiopathy w...

  12. Problembaseret læring som pædagogisk ide og strategi

    DEFF Research Database (Denmark)

    Riemenschneider, Anni Vester; Kobbelgaard, Lis; Kloppenborg, Kamma Møldrup

    2005-01-01

    Rapporten beskriver et udviklingsarbejde i relation til at tænke problembaseret læring (PBL) som pædagogisk ide og strategi i forbindelse med undervisning i sygeplejefagområdet "Sygeplejeprocessen" på 1. semester på Sygeplejeskolen i Silkeborg.......Rapporten beskriver et udviklingsarbejde i relation til at tænke problembaseret læring (PBL) som pædagogisk ide og strategi i forbindelse med undervisning i sygeplejefagområdet "Sygeplejeprocessen" på 1. semester på Sygeplejeskolen i Silkeborg....

  13. 32 CFR 806.15 - FOIA exemptions.

    Science.gov (United States)

    2010-07-01

    ... information. Review declassified and unclassified parts before release to see if they are exempt by other exemptions. Before releasing a reviewed and declassified document, draw a single black line through all the... addresses. This reporting requirement is exempt from licensing with a reports control symbol (RCS) in...

  14. 12 CFR 1403.12 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Exemptions. 1403.12 Section 1403.12 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION PRIVACY ACT REGULATIONS § 1403.12 Exemptions. Specific... following system of records is exempt from subsections (c)(3), (d), (e)(1), (e)(4) (G), (H), and (I), and (f...

  15. 20 CFR 401.85 - Exempt systems.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Exempt systems. 401.85 Section 401.85... INFORMATION The Privacy Act § 401.85 Exempt systems. (a) General policy. The Privacy Act permits certain types of specific systems of records to be exempt from some of its requirements. Our policy is to exercise...

  16. 17 CFR 250.3 - Exemption of certain banks.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain banks... Exemptions § 250.3 Exemption of certain banks. (a) General exemption. Subject to the provisions of § 250.6 and to the requirements contained in paragraph (c) of this section, any bank shall be exempt from any...

  17. Tegijad meenutavad "52 üllatust ja ideed" / Annika Maior, Ats Parve, Epp Kubu ...[jt.

    Index Scriptorium Estoniae

    2011-01-01

    Kultuuripealinna ootussarjas osalenud räägivad, kuidas idee teostamine kulges. Projektidest "Fantaasiaaed" (Annika Maior), "Camera obscura" (Ats Parve), "Tallinna bussijaam heliseb" (Epp, Kubu, Tõnis Hiiesalu), "Tänavamiimid" (Mihkel Ernits, Kaarel Väli), "Kunstijärjekord" (Flo Kasearu, Aet Ader, Grete Soosalu, Andra Aaloe)

  18. Accessibility Analysis of the Eclipse IDE for Users with Visual Impairment.

    Science.gov (United States)

    Petrausch, Vanessa; Loitsch, Claudia

    2017-01-01

    Integrated Development Environments support software developers during their daily work. However, complex graphical interfaces and various functions disable an accessible development environment. We present the results of an online questionnaire, which identifies accessibility issues regarding the Eclipse IDE, and an inclusive tutorial for Eclipse for people with visual impairment.

  19. Détermination des radionucléides dans le repas. Application aux ...

    African Journals Online (AJOL)

    40 sont des radionucléides naturels présents dans les riz, les tubercules, les bouillons et les friandises. Dans les quatre échantillons des repas du Riz analysés, les activités spécifiques en potassium-40 sont différentes. Cette différence est ...

  20. Efficient construction of approximate call graphs for JavaScript IDE services

    DEFF Research Database (Denmark)

    Feldthaus, Asger; Schäfer, Max; Sridharan, Manu

    2013-01-01

    The rapid rise of JavaScript as one of the most popular programming languages of the present day has led to a demand for sophisticated IDE support similar to what is available for Java or C#. However, advanced tooling is hampered by the dynamic nature of the language, which makes any form of stat...

  1. 21 ideed, millest võiks saada monument või skulptuur / Jüri Saar

    Index Scriptorium Estoniae

    Saar, Jüri, 1973-

    2008-01-01

    Tartu linnavalitsus kogus kokku 21 skulptuuride, monumentide ja mälestustahvlite ideed, et esile tõsta auväärseid kaaslinlasi ning ehitisi. Valmis dokument "Tartu linna monumentide ja skulptuuride rajamise kava aastateks 2008-2013". Kommenteerivad Tiit Kaunissaare ja Jüri Sasi

  2. IDES-EDU – new interdisciplinary education program for Sustainable Buildings

    DEFF Research Database (Denmark)

    Dvorakova, Pavla; Kabele, Karel; Brunsgaard, Camilla

    2013-01-01

    Buildings fulfilling all requirements related to energy, economy and environment are necessary to be designed by interdisciplinary teams with efficient transfer of information and good knowledge base. IDES EDU is a project co-funded by the Intelligent Energy Europe program in which 15 European...

  3. Ideed on isiksustest tähtsamad / Vilen Künnapu ; intervjueerinud Madli Maruste

    Index Scriptorium Estoniae

    Künnapu, Vilen, 1948-

    2010-01-01

    Rahvusvahelisel üritusel London Festival of Architecture esindas Eestit Vilen Künnapu oma kohaspetsiifilise objektiga "The River Bell" ehk jõekell. Installatsiooni idee sünnist ja teostamisest, arhitektuuri funktsioonist, kunsti rollist tänapäeval

  4. Immersiivne kunst : virtuaalne reaalsus, panoraam ja ruumilise maalikunsti ideed / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-

    2004-01-01

    Virtuaalne reaalsus, ruumilise maalikunsti ideed ja panoraam kui moodsa installatsiooni eelkäija. 19. sajandi panoraamidest. Anton von Werneri eestvõtmisel loodud Sedani lahingu (Prantsuse-Preisi sõjas 1. septembril 1870) panoraamist. Virtuaalse ruumi eelkäijad on Pompei freskod, Baldassaare Peruzzi maalitud Sala delle Prospettive ning Sacro Monte liikumine

  5. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation

    Directory of Open Access Journals (Sweden)

    Castaño Eduardo M

    2008-12-01

    Full Text Available Abstract Background Insulin degrading enzyme (IDE is implicated in the regulation of amyloid β (Aβ steady-state levels in the brain, and its deficient expression and/or activity may be a risk factor in sporadic Alzheimer's disease (AD. Although IDE sub-cellular localization has been well studied, the compartments relevant to Aβ degradation remain to be determined. Results Our results of live immunofluorescence, immuno gold electron-microscopy and gradient fractionation concurred to the demonstration that endogenous IDE from brain tissues and cell cultures is, in addition to its other localizations, a detergent-resistant membrane (DRM-associated metallopeptidase. Our pulse chase experiments were in accordance with the existence of two pools of IDE: the cytosolic one with a longer half-life and the membrane-IDE with a faster turn-over. DRMs-associated IDE co-localized with Aβ and its distribution (DRMs vs. non-DRMs and activity was sensitive to manipulation of lipid composition in vitro and in vivo. When IDE was mis-located from DRMs by treating cells with methyl-β-cyclodextrin (MβCD, endogenous Aβ accumulated in the extracellular space and exogenous Aβ proteolysis was impaired. We detected a reduced amount of IDE in DRMs of membranes isolated from mice brain with endogenous reduced levels of cholesterol (Chol due to targeted deletion of one seladin-1 allele. We confirmed that a moderate shift of IDE from DRMs induced a substantial decrement on IDE-mediated insulin and Aβ degradation in vitro. Conclusion Our results support the notion that optimal substrate degradation by IDE may require its association with organized-DRMs. Alternatively, DRMs but not other plasma membrane regions, may act as platforms where Aβ accumulates, due to its hydrophobic properties, reaching local concentration close to its Km for IDE facilitating its clearance. Structural integrity of DRMs may also be required to tightly retain insulin receptor and IDE for

  6. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis.

    Science.gov (United States)

    Wisedchaisri, Goragot; Chou, C James; Wu, Meiting; Roach, Claudia; Rice, Adrian E; Holmes, Randall K; Beeson, Craig; Hol, Wim G J

    2007-01-16

    The iron-dependent regulator IdeR is a key transcriptional regulator of iron uptake in Mycobacterium tuberculosis. In order to increase our insight into the role of the SH3-like third domain of this essential regulator, the metal-binding and DNA-binding properties of two-domain IdeR (2D-IdeR) whose SH3-like domain has been truncated were characterized. The equilibrium dissociation constants for Co2+ and Ni2+ activation of 2D-IdeR for binding to the fxbA operator and the DNA-binding affinities of 2D-IdeR in the presence of excess metal ions were estimated using fluorescence spectroscopy. 2D-IdeR binds to fxbA operator DNA with similar affinity as full-length IdeR in the presence of excess metal ion. However, the Ni2+ concentrations required to activate 2D-IdeR for DNA binding appear to be smaller than that for full-length IdeR while the concentration of Co2+ required for activation remains the same. We have determined the crystal structures of Ni2+-activated 2D-IdeR at 1.96 A resolution and its double dimer complex with the mbtA-mbtB operator DNA in two crystal forms at 2.4 A and 2.6 A, the highest resolutions for DNA complexes for any structures of iron-dependent regulator family members so far. The 2D-IdeR-DNA complex structures confirm the specificity of Ser37 and Pro39 for thymine bases and suggest preferential contacts of Gln43 to cytosine bases of the DNA. In addition, our 2D-IdeR structures reveal a remarkable property of the TEV cleavage sequence remaining after removal of the C-terminal His6. This C-terminal tail promotes crystal contacts by forming a beta-sheet with the corresponding tail of neighboring subunits in two unrelated structures of 2D-IdeR, one with and one without DNA. The contact-promoting properties of this C-terminal TEV cleavage sequence may be beneficial for crystallizing other proteins.

  7. Hemangioendotelioma epitelióide de pleura Epithelioid hemangioendothelioma of the pleura

    Directory of Open Access Journals (Sweden)

    Patrícia K. Vitório

    2004-02-01

    Full Text Available Relata-se o caso de um paciente exposto profissionalmente a asbesto por dez anos e portador de um tumor pleural muito raro, o hemangioendotelioma epitelióde. O paciente apresentava derrame pleural serohemorrágico, sem evidência de células neoplásicas e com predomínio de linfócitos. A biópsia pleural por agulha revelou processo inflamatório crônico inespecífico, com áreas de tecido mixóide. A videotoracoscopia mostrou nódulos difusos nas pleuras parietal e visceral. A biópsia revelou neoplasia mesenquimal e eram semelhantes às áreas focais observadas na primeira biópsia. O estudo imunohistoquímico demonstrou a presença dos marcadores vasculares CD31, CD34 e Fator VIII, caracterizando a origem vascular do tumor. O paciente foi tratado com cisplatina e ectoposide, tendo o óbito ocorrido três meses após o diagnóstico.Epithelioid hemangioendothelioma (EHE, a very uncommon pleural tumor, was diagnosed in a 61-year-old man with work-related exposure to asbestos. Serohemorrhagic pleural effusion was diagnosed in the work-up of this patient, whose complaints were chest pain and weight loss. A lymphocytic predominance was present in the effusion, but no malignant cells were seen; pleural needle biopsy disclosed only a non-specific inflammatory process. Video thoracoscopy revealed nodules in parietal and visceral pleurae. A biopsy revealed a mesenchymal neoplasm; vascular markers CD 31, CD 34 and VIII factor were present; therefore, diagnosis of HE was accepted. The tumor was not responsive to cisplatin or etoposide and the patient died 3 months after the diagnosis.

  8. 75 FR 14652 - Qualification of Drivers; Exemption Applications; Diabetes

    Science.gov (United States)

    2010-03-26

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemptions from the diabetes standard; request for comments. SUMMARY: FMCSA announces receipt of applications from 27 individuals for exemptions from the prohibition against persons with insulin- treated diabetes...

  9. 75 FR 13647 - Qualification of Drivers; Exemption Applications; Diabetes

    Science.gov (United States)

    2010-03-22

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemptions from the diabetes standard; request for comments. SUMMARY: FMCSA announces receipt of applications from 53 individuals for exemptions from the prohibition against persons with insulin- treated diabetes...

  10. 40 CFR 91.1006 - Manufacturer-owned exemption and precertification exemption.

    Science.gov (United States)

    2010-07-01

    ... displacement, engine family identification, and model year of engine; or person or office to be contacted for... (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Exclusion and Exemption of Marine SI Engines § 91.1006 Manufacturer-owned exemption and precertification exemption. (a...

  11. 40 CFR 89.906 - Manufacturer-owned exemption and precertification exemption.

    Science.gov (United States)

    2010-07-01

    ... displacement, engine family identification, and model year of engine; or person of office to be contacted for... ENGINES Exemption Provisions § 89.906 Manufacturer-owned exemption and precertification exemption. (a) Except as provided in paragraph (b) of this section, any manufacturer-owned nonroad engine, as defined by...

  12. Taxonomia de Coffea arabica L. VI: caracteres morfológicos dos haplóides

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1952-06-01

    Full Text Available No decorrer dos trabalhos de melhoramento do café em execução no Instituto Agronômico de Campinas, plantas haplóides foram encontradas nas variedades typica, bourbon, maragogipe, semperflorens, laurina, erecta, caturra e San Ramon, da espécie Coffea arabica. Todos os haplóides apresentam porte menor e fôlhas mais estreitas e mais finas do que as variedades que lhes deram origem. Apesar de as flores serem completas, nota-se esterilidade muito acentuada. Raramente se formam alguns frutos, e êstes são providos de uma única semente, motivo pelo qual as plantas haplóides são denominadas "monosperma". Os fatôres genéticos dominantes maragogipe (Mg, erecta (Er, caturra (Ct e San Ramon, bem como os gens recessivos semperflorens (sf, e laurina (lr, das variedades estudadas, manifestam-se nas plantas haplóides, de modo semelhante ao que ocorre nas plantas diplóides correspondentes. O fator para coloração bronze dos brotos novos tem dominância incompleta e, na condição heterozigota (Brbr, mostra intensidade intermediária de côr. Nas plantas haplóides contendo um só alelo Br, a côr dos brotos novos é bronze-clara. Uma única dose do fator Na, que também apresenta dominância incompleta, dando, na forma heterozigota (Nana e na presença de tt, o fenótipo conhecido por murta, manifesta-se, na forma haplóide, dando plantas semelhantes às homozigotas ttNaNa, apenas com fôlhas mais estreitas e mais finas. Chamou-se atenção para as linhas puras de café obtidas pela duplicação do número de cromosômios dos haplóides e sua aplicação nos ensaios de linhagens e na determinação das taxas de mutação. As observações realizadas na meiose da espécie C. arabica, bem como os dados das análises genéticas e as observações feitas nesses haplóides parecem indicar que, se essa espécie fôr alotetraplóide, tal origem deve ser bem antiga, comportando-se hoje a espécie C. arábica, como um diplóide normal. As plantas

  13. IDES-EDU: Comprehensive multidisciplinary education programme to accelerate the implementation of EPBD in Europe

    DEFF Research Database (Denmark)

    Wyckmans, Annemie; Almeida, Manuela; Brunsgaard, Camilla

    This paper presents a new education and training programme on integrated energy design developed by fifteen European universities collaborating within the IDES-EDU project (2010-2013), funded by Intelligent Energy Europe. IDES-EDU aims to accelerate the implementation of the Energy Performance...... educational programmes targetting integrated project design at the interface of architecture and engineering. Taking into account local variations in climate, construction and pedagogical approaches, the programme facilitates gradual implementation towards full integration of energy efficiency in building...... are expected learning outcomes, level of integration in existing curricula and alignment with theory and assessment methods. Measures for improvement as well as further dissemination to other European educational facilities are proposed. In this manner, the project will contribute to make the multiple...

  14. Penfigóide bolhoso no lactente Bullous pemphigoid in childhood

    Directory of Open Access Journals (Sweden)

    Ada Lobato Quattrino

    2007-02-01

    Full Text Available O penfigóide bolhoso é doença que comumente acomete pessoas idosas. Desde o primeiro caso na infância, confirmado por imunofluorescência em 1970, cerca de 50 casos foram relatados e poucos ocorreram em crianças com menos de um ano de idade. Apresentase caso de penfigóide bolhoso em lactente de quatro meses de idade e discutem-se as características clínicas e imunopatológicas dessa rara bulose da infância.Bullous pemphigoid typically affects the elderly. Since the first description of bullous pemphigoid in childhood in 1970, about 50 cases have been reported, but only 10 were reported in children under the first year of age. We report a case of bullous pemphigoid in a 4-month-old girl and discuss the clinical and immunopathological features of this rare bullous disease of infancy.

  15. 10 Détermination des radionucléides dans le repas. Application aux ...

    African Journals Online (AJOL)

    ASIMANANA

    ISSN 1813-548X, http://www.afriquescience.info. Frédéric ASIMANANA. Détermination des radionucléides dans le repas. Application aux arts culinaires de Madagascar. Frédéric ASIMANANA. Métrologie Nucléaire et Environnement, Institut National des Sciences et Techniques Nucléaires,. Faculté des Sciences, BP 201, ...

  16. Composição de carotenóides de maracujá-amarelo (Passiflora edulis flavicarpa in natura

    Directory of Open Access Journals (Sweden)

    Silva Sandra Regina da

    2002-01-01

    Full Text Available A composição de carotenóides de maracujá-amarelo in natura (Passiflora edulis comercializado em Campinas, Brasil, foi avaliada utilizando-se cromatografia líquida de alta eficiência. Em todas as amostras foram encontrados os seguintes carotenóides: beta-criptoxantina, prolicopeno, cis-zeta-caroteno, zeta-caroteno, beta-caroteno e 13-cis-beta-caroteno, além de neurosporeno e gama-caroteno em alguns lotes. Em geral, os teores de carotenóides nos diversos lotes foram significativamente diferentes. Em dois dos cinco lotes analisados, o z-caroteno foi o carotenóide principal, contribuindo com 41 e 62% do total de carotenóides, enquanto que em outros dois lotes, o beta-caroteno foi o majoritário, com 55 e 74% do total e em um dos lotes o cis-zeta-caroteno esteve presente em maior concentração, com 29%. Este tipo de inversão entre os carotenóides majoritários não é comumente encontrado em frutas e vegetais.

  17. Hyperparasitism by helminths: new records of cestodes and nematodes in proteocephalid cestodes from South American siluriform fishes Hiperparasitismo por helmintos: novas ocorrências de cestóides e nematóides em cestóides proteocefalídeos de peixes siluriformes da América do Sul

    Directory of Open Access Journals (Sweden)

    Amilcar Arandas Rego

    1989-09-01

    Full Text Available Proteocephalid cestode hyperparasite are reported from numerous proteocephalids occurring in pimelodid fishes in different regions of Brazil. In addition, three specimens of a nematode hyperparasite are reported from the proteocephalid cestode Choanoscolex abscissus from the pimelodid fish Pseudoplatystoma corruscans in Brazil. Previous records of cestode and nematode hyperparasite of cestode are listed, and the possible identities of the Brazilian records are discussed.Cestóides hiperparasitos são descritos de espécies de proteocefalídeos, que ocorrem em peixes pimelodídeos de diferentes regiões do Brasil. Referimos ainda, a ocorrência de nematóide hiperparasito em espécimes de Choanoscolex abscissus, do peixe pimelodídeo, Pseudoplatystoma carruscans. São citadas as referências anteriores de cestóides e nematóides hiperparasitos, e discutida a possível identificação dos mesmos.

  18. Síndrome carcinóide: relato de caso Carcinoid syndrome: case report

    Directory of Open Access Journals (Sweden)

    Ane Beatriz Mautari Niwa

    2008-12-01

    Full Text Available Os tumores carcinóides são raros, com incidência aproximada de um a dois casos por 100.000 habitantes. Estima-se que a síndrome carcinóide - que se caracteriza por flushing, diarréia, dor abdominal e, em menor freqüência, pelagra, broncoespasmo e doença valvar cardíaca - ocorra em menos de 10% dos doentes. Entretanto, nos casos avançados a incidência varia de 40 a 50%. Estudos retrospectivos e de série de casos mostram que as manifestações cutâneas são freqüentes nessa entidade, embora sejam raramente relatadas. Apresenta-se um caso de síndrome carcinóide diagnosticadoa partir das manifestações dermatológicas.Carcinoid tumors are rare neoplasms with an estimated incidence of 1 to 2 cases per 100,000 inhabitants. The malignant carcinoid syndrome, characterized by flushing, diarrhea, abdominal pain and, less frequently, pellagra, bronchospasm and valvular disease, occurs in less than 10% of patients. Nevertheless, in advanced stages of the disease, the incidence is about 40 to 50%. Retrospective studies and descriptive case series have shown that cutaneous involvement is relatively common but has rarely been reported. We present a case of carcinoid syndrome diagnosed with basis on skin findings on clinical examination.

  19. The study of concentration effects of target hybridization on cervical cancer detection using interdigitated electrodes (IDE)

    Science.gov (United States)

    Noriani, C.; Hashim, U.; Azizah, N.

    2016-07-01

    Human Papilloma Virus (HPV) is a virus from the Papilloma virus family that affects human skin and the moist membranes that line the body, such as the throat, mouth, feet, fingers, nails, anus and cervix [1]. There are over 100 types, of which 40 can affect the genital area. Most known HPV types cause no symptoms to humans. Some, however, can cause verrucae (warts), while a small number can increase the risk of developing several cancers, such as that of the cervix, penis, vagina, anus and oropharynx (oral part of the pharynx - throat cancer). HPV strand 16 and 18 are well known for causing the advanced of Cervical Cancer (CC). Currently, integrated electrodes (IDEs) are implemented in various sensing devices including surface acoustic wave (SAW) sensors, chemical sensors as well as current MEMS biosensors. IDEs have been optimized for a variety of sensing applications including biosensors sensors, acoustic sensors, and chemical sensors. However, optimization for cancer cell detection has yet to be reported. The output signal strength of IDEs is controlled through careful design of the active area, width, and spacing of the electrode fingers the efficiency of DNA nanochip depends mainly on the sequence of the capture probes and the way they are attached to the support [2]. This strategy presented a simple, rapid and sensitive platform for HPV detection and would become a powerful tool for pathogenic microorganisms screening in clinical diagnosis. The coupling procedure must be quick, covalent, and reproducible.

  20. Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

    Directory of Open Access Journals (Sweden)

    Gabriela Soncini Pasetto

    2013-08-01

    Full Text Available OBJETIVO: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. MÉTODOS: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. RESULTADOS: De um total de 18 olhos, 7 (38.9% foram incluídos no estudo. Cinco (71,4% pacientes foram tratados exclusivamente com termoterapia transpupilar, em 1 (14,2% olho a crioterapia foi simultânea, 1 (14,2% suplementou braquiterapia - placa episcleral. Três (42.8% sofreram recorrência, 2 (28.5% apresentaram metástases (um óbito, 2 foram enucleados. Complicações foram encontradas em 3 olhos: dobras maculares em 2, hemorragia vítrea em 1. Nos olhos enucleados, não havia extensão extraescleral, porém células interesclerais foram identificadas. CONCLUSÃO: Termoterapia transpupilar mostra um declínio em sua eficácia e conserva os riscos de metástases em períodos mais longos de acompanhamento, sendo necessária uma definição mais exata de seu papel nos melanomas de coróide.

  1. Nodulose reumatóide epibulbar bilateral: relato de caso Bilateral epibulbar rheumatoid nodulosis: case report

    Directory of Open Access Journals (Sweden)

    Namir Clementino Santos

    2006-06-01

    Full Text Available Apresentamos o caso de uma paciente de 64 anos, com diagnóstico de artrite reumatóide, apresentando nódulos episclerais bilaterais, sem inflamação articular ativa. A biópsia das lesões revelou presença de granulomas com células epitelióides e fibroblastos em orientação radial à zona central de degeneração necrobiótica do colágeno da episclera e esclera superficial e infiltrados de linfócitos e plasmócitos em todos os níveis da substância própria da conjuntiva. Na literatura reumatológica o desenvolvimento de nódulos reumatóides na ausência de doença articular ativa é chamado de "nodulosis rheumatoidis".A 64-year-old woman with a diagnosis of rheumatoid arthritis developed painless bilateral episcleral rheumatoid nodules without any flareup of her associated disease. Biopsy of the lesions disclosed a lymphocytic and plasmacytic infiltration within the conjunctiva, overlying palisading granulomas with multinucleated giant cells, and central necrobiotic degeneration of the collagen of the episclera and superficial sclera. The rheumatologic designation for the development of groups of nodules in inactive rheumatoid arthritis is rheumatoid nodulosis.

  2. Tumores de plexo coróide: estudo epidemiológico comparativo de 24 casos

    Directory of Open Access Journals (Sweden)

    Torres Luiz Fernando Bleggi

    2004-01-01

    Full Text Available Tumores derivados do plexo coróide são neoplasias raras do sistema nervoso central que acometem principalmente crianças. Este estudo apresenta uma série de 38 pacientes com tumores de origem neuroectodérmica, dentre os quais 24 possuem diagnóstico histológico e/ou imunoistoquímico de Carcinoma do Plexo Coróide (CPC. Destes, 16 eram do gênero masculino. O local predominantemente acometido foi o ventrículo lateral esquerdo. As manifestações clínicas mais freqüentes foram hidrocefalia, hipertensão intracraniana e crises convulsivas. Todos os pacientes foram submetidos a tratamento cirúrgico. Houve um óbito no per-operatório e outro no pós-operatório imediato. Nove pacientes tiveram recidiva, evoluindo a óbito em tempo médio de 12,3 meses. Sete estão vivos. Os demais casos não apresentavam dados disponíveis. Em Curitiba, o CPC tem uma alta prevalência em relação a outros tumores do plexo coróide, podendo estar relacionado a algum agente patogênico.

  3. Coqoon - An IDE for Interactive Proof Development in Coq

    DEFF Research Database (Denmark)

    2016-01-01

    these projects using the Eclipse common build system. Coqoon takes advantage of the latest features of Coq, including asynchronous and parallel processing of proofs, and—when used together with a third-party OCaml extension for Eclipse—can even be used to work on large developments containing Coq plugins....

  4. 21 CFR 1308.34 - Exempt anabolic steroid products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Exempt anabolic steroid products. 1308.34 Section... SUBSTANCES Exempt Anabolic Steroid Products § 1308.34 Exempt anabolic steroid products. The list of compounds, mixtures, or preparations that contain an anabolic steroid that have been exempted by the Administrator...

  5. 21 CFR 801.127 - Medical devices; expiration of exemptions.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Medical devices; expiration of exemptions. 801.127... (CONTINUED) MEDICAL DEVICES LABELING Exemptions From Adequate Directions for Use § 801.127 Medical devices; expiration of exemptions. (a) If a shipment or delivery, or any part thereof, of a device which is exempt...

  6. 75 FR 19676 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-04-15

    ... of Drivers; Exemption Renewals; Vision AGENCY: Federal Motor Carrier Safety Administration (FMCSA... the exemptions from the vision requirement in the Federal Motor Carrier Safety Regulations for 15 individuals. FMCSA has statutory authority to exempt individuals from the vision requirement if the exemptions...

  7. 75 FR 1453 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-01-11

    ...-2007-27897; FMCSA- 2007-28695; FMCSA-2007-29019] Qualification of Drivers; Exemption Renewals; Vision.... SUMMARY: FMCSA previously announced its decision to renew the exemptions from the vision requirement in... exempt individuals from the vision requirement if the exemptions granted will not compromise safety. The...

  8. 40 CFR 92.908 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false National security exemption. 92.908... Provisions § 92.908 National security exemption. A manufacturer or remanufacturer requesting a national security exemption must state the purpose for which the exemption is required and the request must be...

  9. 40 CFR 90.908 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false National security exemption. 90.908... Exemption of Nonroad Engines from Regulations § 90.908 National security exemption. (a)(1) Any nonroad... defense, will be considered exempt from this part for purposes of national security. No request for...

  10. 28 CFR 16.84 - Exemption of Immigration Appeals System.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of Immigration Appeals System... MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.84 Exemption of Immigration...) Decisions of the Board of Immigration Appeals (JUSTICE/BIA-001). This exemption applies only to the extent...

  11. 21 CFR 801.110 - Retail exemption for prescription devices.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Retail exemption for prescription devices. 801.110... (CONTINUED) MEDICAL DEVICES LABELING Exemptions From Adequate Directions for Use § 801.110 Retail exemption for prescription devices. A device subject to § 801.109 shall be exempt at the time of delivery to the...

  12. 7 CFR 301.80-2b - Exempted articles. 1

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Exempted articles. 1 301.80-2b Section 301.80-2b....80-2b Exempted articles. 1 1 The articles hereby exempted remain subject to applicable restrictions under other quarantines. (a) The following articles are exempt from the certification and permit and...

  13. 7 CFR 15a.15 - Exempt activities.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Exempt activities. 15a.15 Section 15a.15 Agriculture Office of the Secretary of Agriculture EDUCATION PROGRAMS OR ACTIVITIES RECEIVING OR BENEFITTING FROM FEDERAL FINANCIAL ASSISTANCE Coverage § 15a.15 Exempt activities. (a) These regulations shall not apply to...

  14. 22 CFR 215.14 - Specific exemptions.

    Science.gov (United States)

    2010-04-01

    ... Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REGULATIONS FOR IMPLEMENTATION OF PRIVACY ACT OF...: Provided, however, That if any individual is denied any right, privilege, or benefit to which he or she... exemptions, are set forth below: (1) Criminal Law Enforcement Records. If the 5 U.S.C. 552a(j)(2) exemption...

  15. 45 CFR 705.13 - Exemptions.

    Science.gov (United States)

    2010-10-01

    ... agency: (1) Exemption (k)(2) of the Act. Investigatory material compiled for law enforcement purposes... the Act. Investigatory material maintained solely for the purposes of determining an individual's...) Appeals, Grievances, and Complaints (staff)—Commission Project, CRC-001. Exempt partially under 5 U.S.C...

  16. 7 CFR 915.110 - Exemption certificates.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Exemption certificates. 915.110 Section 915.110 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... the Manager of the Avocado Administrative Committee on its behalf, of one or more exemption...

  17. 15 CFR 30.37 - Miscellaneous exemptions.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Miscellaneous exemptions. 30.37 Section 30.37 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Exemptions From the Requirements for the Filing...

  18. 7 CFR 985.58 - Exempt oil.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Exempt oil. 985.58 Section 985.58 Agriculture... HANDLING OF SPEARMINT OIL PRODUCED IN THE FAR WEST Order Regulating Handling Volume Limitations § 985.58 Exempt oil. Oil held by a producer or handler on the effective date of this subpart shall not be...

  19. 32 CFR 299.7 - Exempt records.

    Science.gov (United States)

    2010-07-01

    ... published in the Federal Register, made available in a reading room, or provided in response to requests... personnel rules and practices of an agency. (3) Records which concern matters that a statute specifically exempts from disclosure, so long as the statutory exemptions permit no discretion on what matters are...

  20. 46 CFR 32.53-3 - Exemptions.

    Science.gov (United States)

    2010-10-01

    ... System § 32.53-3 Exemptions. (a) The Assistant Commandant for Marine Safety and Environmental Protection grants exemptions for crude oil tankers of less than 40,000 deadweight tons not fitted with high capacity.... (c) Each request must be supported by documentation showing that: (1) The system would be detrimental...

  1. 46 CFR 115.920 - Exemptions.

    Science.gov (United States)

    2010-10-01

    ... written request from the owner or managing operator submitted to the Commandant via the cognizant OCMI. (d... Exemption Certificates are issued by the cognizant OCMI unless any changes to the vessel or its operations have occurred that change the information on the SOLAS Exemption or Passenger Ship Safety Certificates...

  2. 40 CFR 93.126 - Exempt projects.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Exempt projects. 93.126 Section 93.126... Implementation Plans of Transportation Plans, Programs, and Projects Developed, Funded or Approved Under Title 23 U.S.C. or the Federal Transit Laws § 93.126 Exempt projects. Notwithstanding the other requirements...

  3. 7 CFR 1209.252 - Exemption procedures.

    Science.gov (United States)

    2010-01-01

    ... or organic handling operation certificate provided by a USDA-accredited certifying agent as defined... year shall apply to the Council, on a form provided by the Council, for a Certificate of Exemption. The.... (2) To apply for an exemption for organic mushrooms: (i) An eligible mushroom producer shall submit a...

  4. 7 CFR 1221.117 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... or organic handling operation certificate provided by a USDA accredited certifying agent as defined... importer desiring an exemption shall apply to the Board, on a form provided by the Board, for a certificate... may be granted. The Board then will issue, if deemed appropriate, a certificate of exemption to each...

  5. 16 CFR 310.6 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Exemptions. 310.6 Section 310.6 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS TELEMARKETING SALES RULE § 310.6 Exemptions. (a) Solicitations to induce charitable contributions via outbound telephone calls...

  6. 29 CFR 780.329 - Exempt work.

    Science.gov (United States)

    2010-07-01

    ... and reproduce on range lands is necessary to see that the animals receive adequate care, water, salt... 29 Labor 3 2010-07-01 2010-07-01 false Exempt work. 780.329 Section 780.329 Labor Regulations... Provisions § 780.329 Exempt work. (a) The standard that must be used to determine whether the individual...

  7. 10 CFR 55.13 - General exemptions.

    Science.gov (United States)

    2010-01-01

    ... REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.13 General exemptions. The regulations... presence of a licensed operator or senior operator, manipulates the controls of— (1) A research or training reactor as part of the individual's training as a student, or (2) A facility as a part of the individual's...

  8. 40 CFR 91.1007 - Display exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Display exemption. 91.1007 Section 91....1007 Display exemption. An uncertified marine SI engine is a display engine when it is to be used solely for display purposes, will only be operated incident and necessary to the display purpose, and...

  9. 40 CFR 89.907 - Display exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Display exemption. 89.907 Section 89....907 Display exemption. Where an uncertified nonroad engine is a display engine to be used solely for display purposes, will only be operated incident and necessary to the display purpose, and will not be...

  10. 40 CFR 90.907 - Display exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Display exemption. 90.907 Section 90... of Nonroad Engines from Regulations § 90.907 Display exemption. Where an uncertified nonroad engine is a display engine to be used solely for display purposes, will only be operated incident and...

  11. 40 CFR 85.1707 - Display exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Display exemption. 85.1707 Section 85... Engines § 85.1707 Display exemption. Where an uncertified vehicle or engine is a display vehicle or engine to be used solely for display purposes, will not be operated on the public streets or highways except...

  12. Expressão citofotométrica da Caspase-3 no carcinoma papilífero da tireóide e no bócio colóide

    Directory of Open Access Journals (Sweden)

    Luciana Rodrigues Queiroz de Souza

    Full Text Available OBJETIVO: Descrever a expressão citofotométrica quantitativa do marcador caspase-3 no bócio colóide e no carcinoma papilífero da tireóide e comparar a imunoexpessão entre as doenças. MÉTODOS: Realizou-se estudo imunoistoquímico da proteína caspase-3 em 17 blocos de parafina de carcinoma papilífero da tiróide e 20 de bócio colóide, através do sistema SAMBA 4000 - (Sistema de análise microscópica de busca automática, objetivando-se analisar duas variáveis: índice de marcagem e densidade óptica. RESULTADOS: Houve diferença significativa quanto ao índice de marcagem da caspase-3, entre o bócio colóide e o carcinoma papilífero, sendo maior no carcinoma, e não foi encontrada diferença significativa quanto à densidade óptica. Para o bócio colóide, o coeficiente de correlação estimado entre o índice de marcagem e a densidade óptica foi igual a 0,72, indicando assim, a rejeição da hipótese nula (p <0,001, afirmando-se que existe associação positiva e significativa entre o índice de marcagem e a densidade óptica da caspase-3. Para o carcinoma papilífero da tiróide, o coeficiente de correlação estimado entre o índice de marcagem e a densidade óptica 3 foi de 0,34. O resultado do teste estatístico indicou que não se pode afirmar que existe associação entre esses parâmetros. CONCLUSÃO: Para o bócio colóide existe associação positiva e significativa entre as duas variáveis, índice de marcagem e a densidade óptica da caspase-3, enquanto que para o carcinoma papilífero não existe essa associação. O estudo comparativo entre a análise quantitativa da caspase-3, demonstrou que a apoptose é mais evidente no carcinoma papilífero do que no bócio colóide.

  13. The Anti-TNF-α Therapy in the Rheumatoid Arthritis A Terapia Anti-TNF-α na Artrite Reumatóide

    Directory of Open Access Journals (Sweden)

    Lilian Resende Faleiro

    2011-06-01

    Full Text Available Rheumatoid arthritis is a chronic, systemic autoimmune disease of unknown etiology that involves predominantly synovial articulations, which can lead to deformity and destruction. With the progression of the disease, patients with Rheumatoid Arthritis develop inability to perform activities of daily living both as a professional, generating a significant economic impact for the patient and to society. Although the exact cause of rheumatoid arthritis remains unknown, studies conducted over the past two decades has enabled greater understanding of the pathogenesis of this disease. This knowledge has allowed the development of new therapies used to treat severe forms of the disease. The main goal of treatment is to achieve remission, however, when this can not be expected to prevent joint damage and loss of function and even reduce pain. The latest strategies for the treatment of Rheumatoid Arthritis involve the early diagnosis and aggressive control of inflammation. The recognition of pro-inflammatory cytokines expressed more as tumor necrosis factor α (TNF-α and interleukin (IL 1 and IL6 enabled developing new therapies directed against these cytokines targets. TNF-α is a proinflammatory cytokine that plays a key role in immune response, defense against microorganisms and the inflammatory process. Biological agents that inhibit TNF-α are considered effective in reducing activity and in the retardation of structural joint damage in rheumatoid arthritis, especially in forms refractory to conventional treatments. Currently, they are available in Brazil, three anti-TNF-α: infliximab, etanercept and adalimumab. These drugs are relatively safe for Rheumatoid Arthritis, but may, however, present serious infectious complications such as reactivation of latent tuberculosis.The high cost of these drugs, their use in hospital and the risk to opportunistic infections remain the limiting factors for its widespread use in the treatment of Rheumatoid

  14. 4 CFR 81.6 - Records which may be exempt from disclosure.

    Science.gov (United States)

    2010-01-01

    ... limited to, business sales statistics, inventories, customer lists, scientific or manufacturing processes... documents which would be detrimental to an agency decision making. (k) Records in addition to those... are part of the deliberative process. For example, this exemption includes internal communications...

  15. 78 FR 46260 - Sorbitan Monooleate Ethylene Oxide Adduct; Exemption From the Requirement of a Tolerance

    Science.gov (United States)

    2013-07-31

    ... formulations for use on food-contact surfaces in public eating places, dairy-processing equipment, and food... Federal Food, Drug, and Cosmetic Act (FFDCA), requesting the establishment of an exemption from the... formulations applied to food-contact surfaces in public eating places, dairy-processing equipment, and food...

  16. TARANIS XGRE and IDEE detection capability of terrestrial gamma-ray flashes and associated electron beams

    Science.gov (United States)

    Sarria, David; Lebrun, Francois; Blelly, Pierre-Louis; Chipaux, Remi; Laurent, Philippe; Sauvaud, Jean-Andre; Prech, Lubomir; Devoto, Pierre; Pailot, Damien; Baronick, Jean-Pierre; Lindsey-Clark, Miles

    2017-07-01

    With a launch expected in 2018, the TARANIS microsatellite is dedicated to the study of transient phenomena observed in association with thunderstorms. On board the spacecraft, XGRE and IDEE are two instruments dedicated to studying terrestrial gamma-ray flashes (TGFs) and associated terrestrial electron beams (TEBs). XGRE can detect electrons (energy range: 1 to 10 MeV) and X- and gamma-rays (energy range: 20 keV to 10 MeV) with a very high counting capability (about 10 million counts per second) and the ability to discriminate one type of particle from another. The IDEE instrument is focused on electrons in the 80 keV to 4 MeV energy range, with the ability to estimate their pitch angles. Monte Carlo simulations of the TARANIS instruments, using a preliminary model of the spacecraft, allow sensitive area estimates for both instruments. This leads to an averaged effective area of 425 cm2 for XGRE, used to detect X- and gamma-rays from TGFs, and the combination of XGRE and IDEE gives an average effective area of 255 cm2 which can be used to detect electrons/positrons from TEBs. We then compare these performances to RHESSI, AGILE and Fermi GBM, using data extracted from literature for the TGF case and with the help of Monte Carlo simulations of their mass models for the TEB case. Combining this data with the help of the MC-PEPTITA Monte Carlo simulations of TGF propagation in the atmosphere, we build a self-consistent model of the TGF and TEB detection rates of RHESSI, AGILE and Fermi. It can then be used to estimate that TARANIS should detect about 200 TGFs yr-1 and 25 TEBs yr-1.

  17. Efeito de diferentes doses de flavonóides em ratos hiperlipidêmicos

    Directory of Open Access Journals (Sweden)

    OLIVEIRA Tania Toledo de

    2002-01-01

    Full Text Available O objetivo deste estudo foi avaliar o efeito de diferentes doses de baicaleína, morina, naringenina, naringina, quercetina e rutina no aumento dos níveis de colesterol-HDL e trigliceróis em ratos hiperlipidêmicos. Tais flavonóides foram administrados em 3 doses (5, 10, 15 mg/animal a ratos machos da raça Wistar, com 30 dias de vida, alimentados com dieta não purificada de fórmula da marca Labina®. A hiperlipidemia foi induzida pela administração de Triton, na dose de 300 mg/kg de peso vivo. Após 24 horas, os flavonóides foram administrados, sendo cada dose aplicada em grupos de 8 animais. Após 48 horas da aplicação do Triton, os animais foram anestesiados e, por punção cardíaca, amostras de sangue foram coletadas para realização das análises de colesterol, colesterol-HDL e triacilgliceróis no soro. Os melhores resultados para a redução do colesterol foram obtidos com os flavonóides quercetina e rutina, na dose de 5 mg, e naringenina, na dose de 10 mg. A baicaleína, nas doses de 5 e 10 mg, foi a que apresentou as menores reduções para colesterol-HDL. Já para as concentrações de triacilgliceróis, a baicaleína foi a que mais reduziu este parâmetro, independentemente da dose utilizada.

  18. Laringectomia supracricóide (chep para câncer glótico

    Directory of Open Access Journals (Sweden)

    Roberto R. M. Araújo Lima

    Full Text Available OBJETIVOS: Com a intenção de se avaliar os resultados funcionais e terapêuticos da laringectomia supracricóide com crico-hióide-epiglote-pexia (CHEP foram estudados 50 casos de pacientes com carcinoma epidermóide da glote classificados como T2/T3 submetidos a esta técnica em nossa instituição. MÉTODOS: Foi realizada uma análise retrospectiva entre 1996 e 1999. Classificamos 18 pacientes como T2N0M0 e 32 pacientes como T3N0M0. Quarenta e um pacientes foram submetidos a esvaziamento cervical seletivo lateral bilateralmente, quatro foram submetidos ao mesmo esvaziamento unilateralmente, e cinco não foram esvaziados. Analisamos as complicações e a sobrevida livre de doença pelo método de Kaplan-Meyer. RESULTADOS: Dez pacientes tiveram complicações pós-operatórias, dois foram tratados com complementação da laringectomia. Os 48 pacientes restantes mantiveram a via aérea normal, deglutição e a voz. Três pacientes no grupo submetido a esvaziamento cervical apresentaram linfonodo metastático. Quatro pacientes tiveram recidiva da doença, três com recidiva local, sendo dois tratados com laringectomia total e estão vivos e sem doença, o outro com doença avançada alcançou o óbito pela doença. O paciente que teve recidiva no pescoço foi tratado com esvaziamento cervical mais radioterapia e morreu com doença. Dois pacientes tiveram um segundo tumor primário em orofaringe, sendo um tratado com radioterapia paliativa e morreu com doença e o outro tratado com cirurgia está vivo e sem doença. A sobrevida livre de doença em três anos foi de 88% para pacientes T2 e 72% para pacientes T3. CONCLUSÕES: Esta técnica é útil no tratamento de casos selecionados de carcinoma epidermóide da glote T2/T3 sempre se considerando a extensão da doença. A incidência de complicações necessitando laringectomia total de resgate não compromete a funcionalidade desta técnica. A sobrevivência é comparável aos pacientes submetidos

  19. Interdigitated electrode (IDE) for porcine detection based on titanium dioxide (TiO{sub 2}) thin films

    Energy Technology Data Exchange (ETDEWEB)

    Nordin, N.; Azizah, N. [Institute of Electronic Engineering (INEE), Universiti Malaysia Perlis, 01000 Kangar Perlis (Malaysia); Hashim, U., E-mail: uda@unimap.edu.my [Institute of Electronic Engineering (INEE), Universiti Malaysia Perlis, 01000 Kangar Perlis (Malaysia); School of Microelctronic Engineering, Universiti Malaysia Perlis, 01000 Kangar Perlis (Malaysia)

    2016-07-06

    Interdigited Electrode (IDE) porcine detection can be accomplished to authenticate the halal issue that has been a concern to Muslim not only in Malaysia but all around the world. The method used is photolithography that used the p-type photoresist on the spin coater with 2500 rpm. Bare IDEs device is deposited with Titanium Dioxide (TiO{sub 2}) to improve the performance of the device. The result indicates that current-voltage (I-V) measurement of porcine probe line slightly above porcine target due to negative charges repelled each other. The IDE device can detect the porcine presence in food as lowest as 1.0 µM. Better performance of the device can be achieved with the replacement of gold deposited to trigger more sensitivity of the device.

  20. EFEITO DA ADIÇÃO DE HIDROCOLÓIDES EM SISTEMAS MODELO CARNE-ÁGUA

    Directory of Open Access Journals (Sweden)

    Crispin Humberto GARCIA-CRUZ

    2009-07-01

    Full Text Available

    RESUMO: Foram testados diferentes tipos de hidrocolóides comerciais num sistema carne-água na proporção 1:2. Utilizaram-se diferentes concentrações (1% a 6% dos hidrocolóides: carboximetilcelulose de sódio, gelatina, amido de mandioca, amido modificado por fosfatação, goma arábica, goma guar, goma tragacanta, goma xantana, goma locusta, carragena, alginato de sódio, pectina de alto e baixo teor de metoxilação e a mistura das gomas xantana-locusta. Dos resultados obtidos, selecionaram-se aqueles hidrocolóides que proporcionaram maior estabilidade ao sistema após o cozimento. Os hidrocolóides selecionados foram as gomas guar, xantana, locusta e a mistura xantana-locusta, sendo que, destes, a goma xantana, a goma guar e a goma locusta proporcionaram melhores resultados na estabilidade do sistema ao cozimento (99,0%, 90,5% e 91,0%, respectivamente e a menor sinerese (0,01; 0,08 e 0,10 ml/g de pasta na concentração de 1,0%. Determinou-se também a capacidade emulsificante dos hidrocolóides anteriormente selecionados. Os resultados obtidos mostraram que a goma xantana proporcionou a capacidade emulsificante mais elevada, quando comparada com a capacidade emulsificante obtida com as gomas guar, locusta e a mistura xantana-locusta. PALAVRAS-CHAVE: Hidrocolóides; sistema modelo; emulsão; gomas.

  1. HPV DNA target hybridization concentrations studies using interdigitated electrodes (IDE) for early detection of cervical cancer

    Science.gov (United States)

    Noriani, C.; Hashim, U.; Azizah, N.; Nadzirah, Sh.; Arshad, M. K. Md; Ruslinda, A. R.; Gopinath, Subash C. B.

    2017-03-01

    Human Papillomaviruses (HPV) is the major cause of cervical cancer. HPV 16 and HPV 18 are the two types of HPV are the most HPV-associated cancers and responsible as a high-risk HPV. Cervical cancer took about 70 percent of all cases due to HPV infections. Cervical cancer mostly growth on a woman's cervix and its was developed slowly as cancer. TiO2 particles give better performance and low cost of the biosensor. The used of 3-aminopropyl triethoxysilane (APTES) will be more efficient for DNA nanochip. APTES used as absorption reaction to immobilize organic biomolecules on the inorganic surface. Furthermore, APTES provide better functionalization of the adsorption mechanism on IDE. The surface functionalized for immobilizing the DNA, which is the combination of the DNA probe and the HPV target produces high sensitivity and speed detection of the IDE. The Current-Voltage (IV) characteristic proved the sensitivity of the DNA nanochip increase as the concentration varied from 0% concentration to 24% of APTES concentration.

  2. Parasitóides de Cerconota anonella (Sepp., 1830 (Lep.: Oecophoridae em gravioleira (Annona muricata L.

    Directory of Open Access Journals (Sweden)

    Broglio-Micheletti Sônia Maria Forti

    2000-01-01

    Full Text Available A quantificação de inimigos naturais presentes em uma cultura é importante, porque influi nas decisões a serem tomadas em relação ao Manejo Integrado de Pragas. Assim, este trabalho teve por objetivos identificar e quantificar gêneros de parasitóides de Cerconota anonella (Sepp. coletados na cultura de graviola entre março de 1997 e abril de 1998 em Maceió, AL (lat.9°S, long. 35°W. O parasitismo foi determinado pela relação entre o número de formas biológicas dos inimigos naturais e o de formas biológicas da praga e dos parasitóides. Os insetos, por ordem de incidência, foram: Apanteles sp. (Hymenoptera: Braconidae, Rhysipolis sp. (Hymenoptera: Braconidae e Xiphosomella sp. (Hymenoptera: Ichneumonidae. Apanteles sp. predominou durante o período. Os menores percentuais de parasitismo total foram observados no mês de outubro de 1997 (6,60% e os maiores em janeiro de 1998 ( 80,27%, resultando em um parasitismo médio anual de 38,1%.

  3. Observações citológicas em citrus: ll. variedades triplóides

    Directory of Open Access Journals (Sweden)

    C. A. Krug

    1944-01-01

    Full Text Available No presente trabalho apresenta-se um breve resumo dos conhecimentos atuais sôbre a citologia do gênero Citrus; descrevem-se, a seguir, duas variedades triplóides de interêsse econômico. Admite-se que uma delas se tenha derivado da outra por meio de um "seedling" nucelar. Os caracteres morfológicos e citológicos dêstes triplóides são apresentados em detalhes. Chama-se a atenção para a importância da triploidia nos trabalhos de melhoramento das plantas cítricas.A review is presented of citrus cytology and account is given of the author's investigations of this subject. Two triploid citrus varieties are described which are of economic importance. It appears probable that one of these is a nucellar seedling derived from the other. The morphological and cytological characteristics of these triploids are given in detail. Attention is called to the importance of triploidy in citrus breeding.

  4. MeTA studio: a cross platform, programmable IDE for computational chemist.

    Science.gov (United States)

    Ganesh, V

    2009-03-01

    The development of a cross-platform, programmable integrated development environment (IDE), MeTA Studio, specifically tailored but not restricted to computational chemists working in the area of quantum chemistry with an emphasis on handling large molecules is presented. The IDE consists of a number of modules which include a visualizer and a programming and collaborative framework. The inbuilt viewer assists in visualizing molecules, their scalar fields, manually fragmenting a molecule, and introduces some innovative but simple techniques for handling large molecules. These include a simple Find language and simultaneous multiple camera views of the molecule. Basic tools needed to handle collaborative computing effectively are also included opening up new vistas for sharing ideas and information among computational chemists working on similar problems. MeTA Studio is an integrated programming environment that provides a rich set of application programming interfaces (APIs) which can be used to easily extend its functionality or build new applications as needed by the users. (http://code.google.com/p/metastudio/).

  5. Carcinoma de plexo coróide: relato de quinze casos

    Directory of Open Access Journals (Sweden)

    BLEGGI-TORRES LUIZ F.

    2000-01-01

    Full Text Available O carcinoma de plexo coróide (CPC é um raro tumor do sistema nervoso central (SNC, derivado do epitélio de revestimento dos plexos coróides, que acomete pacientes abaixo dos 3 anos de idade. Apresentamos um estudo clínico, epidemiológico e histopatológico de 15 casos de CPC. Destes, 10 eram do gênero masculino. As idades variaram de 4 meses a 21 anos. Quanto a localização, acometeram predominante o ventrículo lateral (73,3%. Os sinais e sintomas predominantes foram hidrocefalia (62,5%, hipertensão intracrania (25% e crise convulsiva (12,5%. Os pacientes foram submetidos a tratamento cirúrgico com ressecção parcial em 75% dos casos e completa em 25%. Houve um óbito per-operatório. Em 85,7% dos pacientes houve recidiva tumoral, com evolução a óbito em média 13,6 meses após o diagnóstico. Apenas um paciente encontra-se vivo num seguimento de 5 anos. Esses dados suportam o prognóstico sombrio e a alta mortalidade do CPC.

  6. Endurance training inhibits insulin clearance and IDE expression in Swiss mice.

    Directory of Open Access Journals (Sweden)

    José M Costa-Júnior

    Full Text Available Endurance training improves peripheral insulin sensitivity in the liver and the skeletal muscle, but the mechanism for this effect is poorly understood. Recently, it was proposed that insulin clearance plays a major role in both glucose homeostasis and insulin sensitivity. Therefore, our goal was to determine the mechanism by which endurance training improves insulin sensitivity and how it regulates insulin clearance in mice.Mice were treadmill-trained for 4 weeks at 70-80% of maximal oxygen consumption (VO2 max for 60 min, 5 days a week. The glucose tolerance and the insulin resistance were determined using an IPGTT and an IPITT, respectively, and the insulin decay rate was calculated from the insulin clearance. Protein expression and phosphorylation in the liver and the skeletal muscle were ascertained by Western blot.Trained mice exhibited an increased VO2 max, time to exhaustion, glucose tolerance and insulin sensitivity. They had smaller fat pads and lower plasma concentrations of insulin and glucose. Endurance training inhibited insulin clearance and reduced expression of IDE in the liver, while also inhibiting insulin secretion by pancreatic islets. There was increased phosphorylation of both the canonical (IR-AKT and the non-canonical (CaMKII-AMPK-ACC insulin pathways in the liver of trained mice, whereas only the CaMKII-AMPK pathway was increased in the skeletal muscle.Endurance training improved glucose homeostasis not only by increasing peripheral insulin sensitivity but also by decreasing insulin clearance and reducing IDE expression in the liver.

  7. Lesões expansivas do plexo coróide Choroid plexus mass lesions

    Directory of Open Access Journals (Sweden)

    Ernesto Lima Araújo Melo

    2003-12-01

    Full Text Available As lesões expansivas do plexo coróide constituem um grupo bastante amplo e heterogêneo de doenças e seus simuladores. Tumores, infecções, anomalias congênitas, hemorragias, cistos e fenômenos degenerativos são alguns dos exemplos de causas de lesões expansivas do plexo coróide. No presente trabalho fizemos revisão da literatura pertinente, descrevendo os achados de imagem e ilustrando-os com alguns casos do nosso serviço. Apesar de não existir na literatura descrição de sinais patognomônicos, a avaliação criteriosa e sistemática das características das lesões pode sugerir determinada etiologia.Choroid plexus mass lesions encompass a broad and heterogeneous group of diseases and their simulators. Tumors, infections, congenital anomalies, hemorrhage, cysts and degenerative diseases are some examples of mass lesions affecting the choroid plexus. In this article we review the current literature, describing the imaging findings and illustrating choroid plexus mass lesions with some cases diagnosed at our facility. Despite the inexistence of pathognomonic signs, a careful and systematic evaluation of the imaging characteristics may suggest many etiologies.

  8. Tumor desmóide tratado com tamoxifeno: relato de caso

    Directory of Open Access Journals (Sweden)

    Bruno Juste Werneck Côrtes

    2006-03-01

    Full Text Available O tumor desmóide (TD é uma neoplasia benigna, que se origina de estruturas fasciais ou músculo-aponeuróticas, constituída por proliferação fibroblástica. Ocorre em 4 a 13% dos pacientes com polipose adenomatosa familiar (FAP. Apesar de histologicamente benignos, os TD têm comportamento maligno, sendo localmente invasivos e com elevada recorrência após ressecção. Os autores relatam um caso de tumor desmóide tratado cirurgicamente no Hospital Governador Israel Pinheiro - IPSEMG e fazem revisão da literatura sobre o tratamento.The desmoid tumors are benign tumors arising from fibroaponeurotic tissue. They occur in 4 to 13% patients who present familial adenomatous polyposis. Although a benign disease, desmoid tumors are focally invasive. They do not metastasize but can be lethal because of aggressive growth with pressure and erosion causing small bowel obstruction. Their tendency to recur (65% to 85% after removal has encouraged a conservative approach to management. The authors report the case of a patient who presented intra-abdominal desmoid tumor, treated surgically in the Hospital Governador Israel Pinheiro - Belo Horizonte (MG and discuss the therapeutic options in the literature.

  9. Meningioma com transformação rabdóide: relato de caso

    Directory of Open Access Journals (Sweden)

    Costa Jr Leodante Batista da

    2003-01-01

    Full Text Available Meningiomas correspondem a cerca de 20% dos tumores intracranianos, com incidência aproximada em 2,3 por 100000. Considerando-se os achados em autópsia, estes tumores representam 30% dos tumores intracranianos. A maioria destas lesões é benigna, sendo o prognóstico do paciente diretamente relacionado à facilidade de ressecção cirúrgica da lesão. A incidência de meningiomas malignos é baixa, cerca de 0,17 por 100000, representando cerca de 1 a 11% dos meningiomas . Tal variação na incidência entre as séries ocorre devido a diferenças nos critérios de definição de malignidade para estes tumores. Só recentemente têm sido relatados casos de meningiomas com morfologia rabdóide, descritos como tumores de comportamento extremamente agressivo. Relatamos o caso de um meningioma rabdóide, em mulher de 56 anos, tratado cirurgicamente em duas ocasiões num período de 6 meses, com êxito letal devido à recidiva local da lesão, apesar de radioterapia e quimioterapia.

  10. Influence of thermal conditions on successful ide (Leuciscus idus L. artificial reproduction during spawning season

    Directory of Open Access Journals (Sweden)

    Dariusz Kucharczyk

    2011-10-01

    Full Text Available Two forms of ide Leuciscus idus (L. spawners: wild-coloured and ornamental: yellow-coloured were kept at three various temperature regimes shortly before spawning at optimal temperature regimes (group 1, under natural temperature conditions (group 2 and in rapidly increasing temperature (group 3. The quality and quantity of collected semen, ovulation rate and survival rate of embryos to the eyed-egg-stage were recorded. The quality of semen from group 3 (where the temperature increased over the thermal spawning optimum was the worst (46 and 51% motility of spermatozoa for the wild-coloured and yellow form, respectively. The quantity of collected semen also was the lowest in the same groups (1.1 and 1.0 cm3 kg-1 for the wild-coloured and yellow form, respectively. Increasing the temperature to 16°C also caused a decreasing percentage of ovulated females (70% and 60% of ovulation for wild-coloured and yellow form, respectively and biological quality of eggs (48.9 and 47.8% embryo survival for wild-coloured and yellow form, respectively. Fluctuations of temperature at a level of 8-14°C (group 2 did not negatively affect spawning results, except for a longer latency time (over 44 hrs. The results suggest that the temperature regime shortly before controlled reproduction of ide plays an important role influencing reproductive success.

  11. El <i>De imaginibus caelestibus de Ibn al-Ḥātim

    Directory of Open Access Journals (Sweden)

    Oliveras, Marc

    2009-06-01

    Full Text Available K. Lippincott and D. Pingree published in 1987 a first Latin edition and English translation of the 15th bilingual Arabic-Latin <i>De imaginibus caelestibus, written originally by the Andalusian Ibn al-Ḥātim in the 10th century. The paper presented here aims to complete the preceding one with an Arabic edition, Spanish translation and some interpretations on the possible sources of talismanic imagery. In this brief astromagic treatise, Ibn al-Ḥātim focuses on twenty eight talismans, related to the lunar mansions, and their magical properties.

    En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV <i>De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥātim se dedica principalmente a describir veintiocho talismanes, relacionados con las mansiones lunares, y sus propiedades mágicas.

  12. Rising rates of vaccine exemptions: problems with current policy and more promising remedies.

    Science.gov (United States)

    Constable, Catherine; Blank, Nina R; Caplan, Arthur L

    2014-04-01

    Parents of school-age children are increasingly claiming nonmedical exemptions to refuse vaccinations required for school entry. The resultant unvaccinated pockets in many areas of the country have been linked with outbreaks of vaccine-preventable diseases. Many states are now focused on reducing rates of nonmedical exemptions by making exemption processes more restrictive or burdensome for the exemptor. These strategies, however, pose ethical problems and may ultimately be inadequate. A shift to strategies that raise the financial liabilities of exemptors may lead to better success and prove ethically more sound. Potential areas of reform include tax law, health insurance, and private school funding programs. We advocate an approach that combines this type of incentive with more effective vaccination education. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. 12 CFR 226.29 - State exemptions.

    Science.gov (United States)

    2010-01-01

    ... Federal law; and (2) There is adequate provision for enforcement. (b) Civil liability. (1) No exemptions granted under this section shall extend to the civil liability provisions of sections 130 and 131 of the...

  14. Tax-exempt yardstick: defining the measurements.

    Science.gov (United States)

    Kuchler, J A

    1992-02-01

    Congress, the Internal Revenue Service (IRS), and state and local governments still are trying to determine requirements a hospital must meet to warrant tax exemption. Revisions to a bill introduced by Rep. Brian Donnelly (D-Mass.) likely will focus Congressional debate on whether charity care or the broader concept of community benefits is the most appropriate measure for not-for-profit hospitals to meet; the IRS may develop intermediate sanctions it could impose on errant not-for-profit facilities in lieu of a total revocation of tax-exempt status; and perhaps the most stringent clamp-down on healthcare facilities' tax-exempt status will come from state and local governments that develop boundaries for tax-exempt hospitals to maintain. Not-for-profit facilities can respond to increased scrutiny by viewing government challenges as opportunities to "tell their stories" about charity care and community benefits.

  15. 40 CFR 87.7 - Exemptions.

    Science.gov (United States)

    2010-07-01

    ... in accordance with procedures established by the Secretary. (e) The Secretary shall publish in the... exemptions. (f) No state or political subdivision thereof may attempt to enforce a standard respecting...

  16. 10 CFR 1004.10 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... by other statutes; confidential, commercial, and financial information; and matters involving....) are covered by this exemption; (4) Trade secrets and commercial or financial information obtained from... lawful national security intelligence investigation, information furnished by a confidential source, (v...

  17. Implementation of pro-poor exemption policy in Tanzania: policy versus reality.

    Science.gov (United States)

    Idd, Aisha; Yohana, Odongo; Maluka, Stephen Oswald

    2013-01-01

    Like many other African countries, Tanzania has been implementing user fee policy in its health sector since the early 1990s. Accompanying user fee, mechanisms were designed that exempted the poor and vulnerable groups of the society from paying user charges. Although studies on the implementation of exemption policies in Tanzania exist, very few have documented the actual process of translating exemption policies into actions-the process of implementation. Drawing from policy analysis and implementation theories, this paper documents the implementation of the waiver (need-based exemptions) policy in Tanzania. The findings indicate that waiver systems, while potentially effective in principle, were ineffective in implementation. Lack of specification of criteria by which the poor could be identified made policy implementers at different levels to implement the policy in their own style. Low level of public awareness about the existence of waiver mechanisms hindered the poor to demand exemptions. Furthermore, fear of loss of revenue at the health facilities and ineffective enforcement mechanisms provided little incentives for local government leaders and health workers to communicate the policy to beneficiaries. It is concluded from this study that to better achieve the objectives of the pro-poor exemption policy, it is important to engage policy implementers more actively in the management and implementation of policies. Additionally, it is imperative to understand the behaviour and practices of policy implementers, especially district health managers, health workers and village and ward leaders, who may react negatively to new policies and implement the policies in ways contrary to what policy makers had intended. Copyright © 2013 John Wiley & Sons, Ltd.

  18. 76 FR 37766 - Specified Commodities Imported Into the United States, Exempt From Import Regulations; Request...

    Science.gov (United States)

    2011-06-28

    ... imported for such outlets as processing, charity, animal feed, seed, and distribution to relief agencies... copy four is retained by the importer. USDA utilizes this information to ensure that imported goods destined for exempt outlets are given no less favorable treatment that that afforded to domestic goods...

  19. 78 FR 59265 - FD&C Yellow No. 5; Exemption From the Requirement of a Tolerance

    Science.gov (United States)

    2013-09-26

    ... used as an inert ingredient (dye) in antimicrobial pesticide formulations applied to food-contact... Cosmetic Act (FFDCA), requesting establishment of an exemption from the requirement of a tolerance. These... antimicrobial pesticide formulations applied to food-contact surfaces in public eating places, dairy- processing...

  20. , paragraph 11 of Directive 2000/13/EC – for permanent exemption from labelling

    DEFF Research Database (Denmark)

    Tetens, Inge

    of wine as clarification processing aids pursuant to Article 6, paragraph 11 of Directive 2000/13/EC – for permanent exemption from labelling. In earlier assessments, the Panel concluded that wines fined with casein/caseinate/milk products may trigger adverse reactions in susceptible individuals under...

  1. 29 CFR 780.803 - Basic conditions of exemption; first part, ginning of cotton.

    Science.gov (United States)

    2010-07-01

    ... cotton. 780.803 Section 780.803 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... FAIR LABOR STANDARDS ACT Employment in Ginning of Cotton and Processing of Sugar Beets, Sugar-Beet... Section 13(b)(15) Introductory § 780.803 Basic conditions of exemption; first part, ginning of cotton...

  2. 40 CFR 90.906 - Manufacturer-owned exemption and precertification exemption.

    Science.gov (United States)

    2010-07-01

    ... Information;” (B) Full corporate name and trademark of manufacturer; (C) Engine displacement, engine family... (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NONROAD SPARK-IGNITION ENGINES AT OR BELOW 19 KILOWATTS Exclusion and Exemption of Nonroad Engines from Regulations § 90.906 Manufacturer-owned exemption...

  3. 40 CFR 92.906 - Manufacturer-owned, remanufacturer-owned exemption and display exemption.

    Science.gov (United States)

    2010-07-01

    ... remanufacturer; (C) Engine displacement, engine family identification, and model year of engine; or person of... LOCOMOTIVE ENGINES Exclusion and Exemption Provisions § 92.906 Manufacturer-owned, remanufacturer-owned... engine is exempt from § 92.1103, without application, if the manufacturer complies with the following...

  4. 7 CFR 1170.9 - Price reporting exemptions.

    Science.gov (United States)

    2010-01-01

    ... cheese per calendar year is exempt from reporting cheddar cheese sales as specified in § 1170.8(a). (b... markets less than 1 million pounds of dry whey per calendar year is exempt from reporting dry whey sales...

  5. 24 CFR 1710.6 - One hundred lot exemption.

    Science.gov (United States)

    2010-04-01

    ... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements § 1710.6 One hundred lot exemption. The sale of lots in a subdivision is exempt from the registration...

  6. 75 FR 1449 - Qualification of Drivers; Exemption Applications; Diabetes

    Science.gov (United States)

    2010-01-11

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... with insulin-treated diabetes mellitus (ITDM) from operating commercial motor vehicles (CMVs) in... . Background On October 29, 2009, FMCSA published a notice of receipt of Federal diabetes exemption...

  7. Research and Development Exemption for New Chemical Review under TSCA

    Science.gov (United States)

    Section 5(h)(3) of TSCA allows EPA to exempt manufacturers of chemical substances from the notice requirements if they manufacture it in small quantities for the purposed of research and development. This page gives an overview of this exemption.

  8. 75 FR 8256 - Nicosulfuron; Pesticide Tolerances for Emergency Exemptions

    Science.gov (United States)

    2010-02-24

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... Exemptions AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation..., hay. This action is in response to EPA granting crisis exemptions to the Texas Department of...

  9. 78 FR 24795 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-04-26

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... for exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces... insulin-treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce...

  10. 77 FR 74271 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-12-13

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the...

  11. 77 FR 63411 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-10-16

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the...

  12. 75 FR 4623 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-01-28

    ... the 27 exemption applications, FMCSA exempts Teddy S. Bioni, John K. Butler, James J. Coffield, Roy E.... Kool, Curtis M. Lawless, Michael E. Lindquist, Philip J.C. Locke, Travis J. Luce, Cameron S. McMillen...

  13. 75 FR 9482 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-03-02

    ... of the 33 exemption applications, FMCSA exempts, Bradley T. Alspach, William M. Arbogast, John E..., Frank L. Ortolani, Paul D. Prillaman, Scott A. Randol, Samuel E. Rees, Danny L. Rolfe, Miguel A. Sanchez...

  14. 41 CFR 109-39.107 - Limited exemptions.

    Science.gov (United States)

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.107 Limited exemptions. The Director, Office of... exemptions from the fleet management system. ...

  15. 78 FR 63285 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-23

    ... exemptions from the prohibition against persons with insulin- treated diabetes mellitus (ITDM) operating... must provide for individual assessment of drivers with diabetes mellitus, and be consistent with the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  16. 78 FR 63280 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-23

    ... exemptions from the prohibition against persons with insulin- treated diabetes mellitus (ITDM) operating... drivers with diabetes mellitus, and be consistent with the criteria described in section 4018 of the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  17. 78 FR 64267 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-28

    ... individuals for exemptions from the prohibition against persons with insulin- treated diabetes mellitus (ITDM... diabetes mellitus, and be consistent with the criteria described in section 4018 of the Transportation... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  18. 78 FR 50486 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-08-19

    ... for exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces... insulin-treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  19. 77 FR 48587 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-08-14

    ... for exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces... insulin-treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  20. 78 FR 79062 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-12-27

    ... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  1. 76 FR 21792 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-04-18

    ... for exemption from the diabetes mellitus standard; request for comments. SUMMARY: FMCSA announces... insulin-treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  2. 78 FR 26419 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-05-06

    ... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  3. 78 FR 65034 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-30

    ... exemptions from the prohibition against persons with insulin- treated diabetes mellitus (ITDM) operating... drivers with diabetes mellitus, and be consistent with the criteria described in section 4018 of the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  4. 78 FR 20381 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-04-04

    ... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  5. 78 FR 56988 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-09-16

    ... exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM) operating... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier Safety Administration (FMCSA). ACTION: Notice of applications for...

  6. 78 FR 1927 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-01-09

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the...

  7. 78 FR 1923 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-01-09

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the...

  8. 75 FR 63536 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2010-10-15

    ... exemption from the diabetes mellitus standard; request for comments. SUMMARY: FMCSA announces receipt of... diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce. If granted, the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  9. 78 FR 63295 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-23

    ... individuals for exemptions from the prohibition against persons with insulin- treated diabetes mellitus (ITDM... individual assessment of drivers with diabetes mellitus, and be consistent with the criteria described in... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  10. 76 FR 3165 - Proposed Exemptions From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2011-01-19

    ... Applicants note that the Transaction proceeded on a more expedited basis than is typical of most... Employee Benefits Security Administration Proposed Exemptions From Certain Prohibited Transaction... proposed exemptions from certain of the prohibited transaction restrictions of the Employee Retirement...

  11. Miopatia por corpos esferóides: relato de caso Spheroid body myopathy: case report

    Directory of Open Access Journals (Sweden)

    Rosana Hermínia Scola

    2005-06-01

    Full Text Available A miopatia por corpos esferóides é doença rara, classificada no grupo das miopatias congênitas relacionadas aos distúrbios da desmina; apresenta, em geral, origem autossômica dominante e com início dos sintomas na fase adulta. Relatamos o caso de menina de sete anos, com diparesia facial, hipotrofia e hipotonia muscular generalizadas, arreflexia profunda generalizada, força muscular proximal nos membros superiores e inferiores e distal dos membros superiores grau 3 e distal nos membros inferiores grau 1. A eletromiografia de agulha evidenciou recrutamento aumentado e potenciais de unidade motora de curta duração e baixa amplitude, caracterizando um padrão miopático. A biópsia muscular revelou padrão misto para miopatia e desinervação e presença de corpos esferóides intracitoplasmáticos compatíveis com a miopatia por corpos esferóides. No presente caso, a paciente apresentou precocemente o início dos sintomas e não há relatos de casos semelhantes na família.Spheroid body myopathy is a rare illness classified in the group of the congenital myopathies as a desmin-related neuromuscular disorder, presenting dominant autosomical origin with the beginning of the symptoms in the adult phase. We report on a seven years old girl with facial paresia, generalized muscular hypotrophy and hypotony, generalized deep areflexia, proximal upper and lower limbs muscular strengh and distal upper limbs grade 3 and distal lower limbs grade 1. Needle electromyography evidenced increased conscription and potentials of motor unit of short duration and low amplitude, characterizing a myopathic standard. The muscle biopsy disclosed mixed standard to myopathy, denervation and inclusion bodies that are consistent to spheroid body myopathy. In this case, the patient presented, in advance, early beginning of the symptoms and there are no similar cases in the family.

  12. Kultuuriajakirjad ja uued ideed / Marc-Olivier Padis, Märt Väljataga ; prantsuse tõlkinud Indrek Koff

    Index Scriptorium Estoniae

    Padis, Marc-Olivier

    2013-01-01

    M.-O. Padise ja M. Väljataga mõttevahetus kultuuriajakirjades avaldatud ideede kõlapinnast ja mõjust. Prantsuse Instituut Eestis poolt 28. septembril 2012. aastal Tallinna Ülikoolis avatud mõttevahetuste sarja "Uued ideed Euroopas" avaüritusel

  13. Phenolic compounds, carotenoids and antioxidant activity in plant products / Compostos fenólicos, carotenóides e atividade antioxidante em produtos vegetais

    Directory of Open Access Journals (Sweden)

    Maria Gabriela Bello Koblitz

    2010-09-01

    Full Text Available The respiratory process and several aerobic cells oxidative reactions lead to the formation of free radicals which contribute to the appearance of different diseases. The human cells depend on their antioxidant ability to provide protection against the prejudicial effects of free radical and reactive oxygen species that are inevitable consequences of aerobic life. Several epidemiologic studies indicate that high plant products ingestion is associated to a reduction in the hazard of a variety of cronical diseases such as arteriosclerosis and cancer. These effects have been specifically attributed to the plant compounds that have antioxidant activity: vitamin C and E, phenolic compounds, specially flavonoids, and carotenoids. Phenolic compounds act as antioxidants, not only for their ability to donate hydrogen atoms or electrons, but also because of their stable intermediary radicals, that prevent the oxidation of many food ingredients, especially lipids. Carotenoids are built by polyene chains in a long conjugated double bonds system, electron rich, which is responsible for the antioxidant activity of these compounds, by the absorption of singlet oxygen and free radicals, to interrupt the chain reaction they are involved in. This paper had as a goal to review the different qualitative and quantitative evaluation methods of the main non-nutrient antioxidants in plant originated foods: phenolic compounds and carotenoids.O processo respiratório e diversas reações oxidativas das células aeróbicas levam à formação de radicais livres, que contribuem para o aparecimento de diversas doenças. As células humanas dependem de sua capacidade antioxidante para fornecer proteção contra os efeitos prejudiciais de radicais livres e espécies reativas do oxigênio, que são conseqüências inevitáveis da vida aeróbica. Vários estudos epidemiológicos indicam que a alta ingestão de produtos vegetais está associada com uma redução no risco de uma

  14. Microangiopatia livedóide associada à síndrome do anticorpo antifosfolípide (SAF Livedoid microangiopathy associated to antiphospholipid antibody syndrome (APS

    Directory of Open Access Journals (Sweden)

    Carla Munhoz Sanches

    2005-12-01

    Full Text Available A microangiopatia livedóide é uma síndrome de hialinização segmentar crônica dos vasos da derme, de causa desconhecida, que afeta principalmente os membros inferiores. Histopatologicamente, tanto as lesões iniciais quanto as tardias são caracterizadas por infiltrado com escassas células inflamatórias, mas com importante angiogênese capilar e microtrombos, aglomerados nodulares de pequenos capilares misturados com hemácias e depósitos de hemossiderina na derme. A ausência de infiltrado perivascular suficiente ou leucocitoclasia argumenta contra vasculite, favorecendo mais um processo trombótico. A microangiopatia livedóide acomete principalmente mulheres jovens e de meia idade. Pode ser idiopática, ou estar associada a alterações na coagulação, incluindo mutação no fator V de Leiden, deficiência da proteína C, aumento na homocisteína plasmática, anormalidades na fibrinólise, ativação plaquetária e síndrome do anticorpo antifosfolípide (SAF. Nós apresentamos um caso de uma paciente com microangiopatia livedóide, associada à presença de SAF com múltiplas úlceras em membros inferiores, que só apresentou melhora clínica após a anticoagulação plena com warfarina e posterior associação com danazol. A microangiopatia livedóide pode representar uma manifestação clínica inicial de um grupo de doenças que causam vasculopatia oclusiva. Logo, todo paciente deve ser investigado para presença de anticorpo antifosfolípide ou de outra causa de trombofilia.Livedoid microangiopathy is a chronic segmental hyalinizing syndrome of dermal blood vessels, of unknown origin, that affects mainly the lower limbs. Histopathologically, both initial as well as late lesion are characterized by few inflammatory cells infiltrate, with prevalent capillary angiogenesis and microthrombi, agglomerate of small capillaries, and dermal deposits of hemosiderin. The absence of a substantial perivascular infiltrate or leukocytoclasia

  15. 78 FR 56842 - Arbitrage Restrictions on Tax-Exempt Bonds

    Science.gov (United States)

    2013-09-16

    ... Regulations for determining the issue price of tax-exempt bonds are no longer appropriate in light of market..., increasing transparency about pricing information in the municipal bond market (for example, publicly... aims to control the burden of unnecessary tax-exempt financings on the tax-exempt bond market by...

  16. 40 CFR 166.35 - Revocation or modification of exemptions.

    Science.gov (United States)

    2010-07-01

    ... of the pesticide under the exemption may cause unreasonable adverse effects on the environment; (3) The pesticide authorized under the exemption is not effective at controlling the pest or conditions...) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS...

  17. 75 FR 22178 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-04-27

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Renewals; Vision AGENCY...: FMCSA previously announced its decision to renew the exemptions from the vision requirement in the... individuals from the vision requirement if the exemptions granted will not compromise safety. The Agency has...

  18. 75 FR 39618 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-07-09

    ...-24015; FMCSA-2007-0071; FMCSA-2008-0021] Qualification of Drivers; Exemption Renewals; Vision AGENCY...: FMCSA previously announced its decision to renew the exemptions from the vision requirement in the... individuals from the vision requirement if the exemptions granted will not compromise safety. The Agency has...

  19. 75 FR 38603 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-07-02

    ...; Exemption Renewals; Vision AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice... the vision requirement in the Federal Motor Carrier Safety Regulations for 21 individuals. FMCSA has statutory authority to exempt individuals from the vision requirement if the exemptions granted will not...

  20. 75 FR 60862 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-10-01

    ...-0174] Qualification of Drivers; Exemption Renewals; Vision AGENCY: Federal Motor Carrier Safety... decision to renew the exemptions from the vision requirement in the Federal Motor Carrier Safety Regulations for 18 individuals. FMCSA has statutory authority to exempt individuals from the vision...

  1. 75 FR 22179 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-04-27

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Renewals; Vision AGENCY...: FMCSA previously announced its decision to renew the exemptions from the vision requirement in the... individuals from the vision requirement if the exemptions granted will not compromise safety. The Agency has...

  2. 75 FR 60861 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-10-01

    ...; Vision AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of final disposition. SUMMARY: FMCSA previously announced its decision to renew the exemptions from the vision... to exempt individuals from the vision requirement if the exemptions granted will not compromise...

  3. 75 FR 27620 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-05-17

    ... Renewals; Vision AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of final disposition. SUMMARY: FMCSA previously announced its decision to renew the exemptions from the vision... to exempt individuals from the vision requirement if the exemptions granted will not compromise...

  4. 24 CFR 1710.7 - Twelve lot exemption.

    Science.gov (United States)

    2010-04-01

    ... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements § 1710.7 Twelve lot exemption. (a) The sale of lots is exempt from the registration requirements of the... exempt from the registration requirements if no more than twelve lots were sold in each previous twelve...

  5. 49 CFR 1150.36 - Exempt construction of connecting track.

    Science.gov (United States)

    2010-10-01

    ... shippers from abuse of market power; and that the construction of connecting track would be of limited... 49 Transportation 8 2010-10-01 2010-10-01 false Exempt construction of connecting track. 1150.36... OPERATE RAILROAD LINES Exempt Transactions Under 49 U.S.C. 10901 § 1150.36 Exempt construction of...

  6. 40 CFR 91.1008 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false National security exemption. 91.1008... Engines § 91.1008 National security exemption. (a)(1) Any marine SI engine, otherwise subject to this part... for purposes of national security. No request for exemption is necessary. (2) Manufacturers may...

  7. 40 CFR 1042.635 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false National security exemption. 1042.635... Compliance Provisions § 1042.635 National security exemption. The standards and requirements of this part and... government responsible for national defense. (b) Manufacturers may request a national security exemption for...

  8. 40 CFR 94.908 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false National security exemption. 94.908... § 94.908 National security exemption. (a)(1) Any marine engine, otherwise subject to this part, that is... regulations in this subpart for reasons of national security. No request for this exemption is necessary. (2...

  9. 40 CFR 89.908 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false National security exemption. 89.908... Provisions § 89.908 National security exemption. (a)(1) Any nonroad engine, otherwise subject to this part... regulations for purposes of national security. No request for exemption is necessary. (2) Manufacturers may...

  10. 9 CFR 590.660 - Inspection of exempted plants.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Inspection of exempted plants. 590.660... Products Plants § 590.660 Inspection of exempted plants. Duly authorized representatives of the Administrator shall make such periodic inspections of exempted plants and records thereof as the Administrator...

  11. 40 CFR 720.38 - Exemptions for test marketing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Exemptions for test marketing. 720.38... CONTROL ACT PREMANUFACTURE NOTIFICATION Applicability § 720.38 Exemptions for test marketing. (a) Any person may apply for an exemption to manufacture or import a new chemical substance for test marketing...

  12. 40 CFR 85.1511 - Exemptions and exclusions.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and Motor Vehicle... exemptions or exclusions are permitted by this paragraph: (1) National security exemption. Vehicles may be imported under the national security exemption found at 40 CFR 85.1708. Only persons who are manufacturers...

  13. 40 CFR 85.1704 - Who may request an exemption.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Exclusion and Exemption of Motor Vehicles and Motor...) Any manufacturer may request a national security exemption under § 85.1708. (c) For manufacturers, vehicles or engines for export purposes are exempt without application, subject to the provisions of § 85...

  14. 48 CFR 252.229-7003 - Tax Exemptions (Italy).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Tax Exemptions (Italy... of Provisions And Clauses 252.229-7003 Tax Exemptions (Italy). As prescribed in 229.402-70(c), use the following clause: Tax Exemptions (Italy) (JAN 2002) (a) The Contractor represents that the...

  15. 40 CFR 166.45 - Duration of crisis exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Duration of crisis exemption. 166.45 Section 166.45 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Crisis Exemptions...

  16. 14 CFR 399.21 - Charter exemptions (except military).

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Charter exemptions (except military). 399.21 Section 399.21 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... Authority § 399.21 Charter exemptions (except military). In deciding applications for exemptions from...

  17. 22 CFR 505.13 - General exemptions (Subsection (j)).

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true General exemptions (Subsection (j)). 505.13... exemptions (Subsection (j)). (a) General exemptions are available for systems of records which are maintained by the Central Intelligence Agency (Subsection (j)(1)), or maintained by an agency which performs as...

  18. 41 CFR 101-39.106 - Unlimited exemptions.

    Science.gov (United States)

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.106 Unlimited exemptions. Unlimited exemptions from inclusion in the fleet... below. Unlimited exemptions do not preclude agencies from requesting fleet management services, if...

  19. 48 CFR 252.229-7005 - Tax exemptions (Spain).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Tax exemptions (Spain... of Provisions And Clauses 252.229-7005 Tax exemptions (Spain). As prescribed in 229.402-70(e), use the following clause: Tax Exemptions (Spain) (JUN 1997) (a) The Contractor represents that the...

  20. 22 CFR 505.14 - Specific exemptions (Subsection (k)).

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Specific exemptions (Subsection (k)). 505.14... exemptions (Subsection (k)). The specific exemptions focus more on the nature of the records in the system of...) Subsection (k)(1). Records which are specifically authorized under criteria established under an Executive...

  1. 7 CFR 301.85-2b - Exempted articles. 1

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Exempted articles. 1 301.85-2b Section 301.85-2b... § 301.85-2b Exempted articles. 1 1 The articles hereby exempted remain subject to applicable restrictions under other quarantines and other provisions of this subpart. (a) The following articles are...

  2. 29 CFR 784.121 - Exempt fisheries operations.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Exempt fisheries operations. 784.121 Section 784.121 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL... Aquatic Products General Character and Scope of the Section 13(a)(5) Exemption § 784.121 Exempt fisheries...

  3. Lupus eritematoso discóide na infância Discoid lupus erythematosus in childhood

    Directory of Open Access Journals (Sweden)

    Maria Carolina de A. Sampaio

    2007-06-01

    Full Text Available OBJETIVO: Realizar revisão da literatura sobre o lupus eritematoso discóide (LED na infância. FONTES DE DADOS: Livros-texto e artigos de revistas indexadas pelo Medline e SciELO nos últimos dez anos, usando as seguintes palavras-chave: "discoid lupus erythematosus", "chronic cutaneous lupus erythematosus", "lupus erythematosus in childhood", "lupus erythematosus in children", "discoid lupus erythematosus in childhood", "discoid lupus erythematosus in children". SÍNTESEDOS DADOS: A idade de início da doença ocorre predominantemente entre cinco e dez anos e a história familiar de lupus eritematoso está presente em 11 a 35% dos casos. A relação gênero feminino/masculino varia de 1/1 a 2,4/1. Por sua vez, 24 a 27% dos pacientes com LED desenvolvem lupus eritematoso sistêmico (LES. Lesões discóides localizadas (que acometem cabeça e pescoço são observadas em 56 a 75% dos pacientes. A face é o local mais acometido. O LED localizado e o generalizado apresentam evolução semelhante. Os achados histológicos são típicos, mostrando dermatite de interface. IgM e IgG são os depósitos mais freqüentes na zona da membrana basal da epiderme. Os tratamentos geralmente utilizados são: fotoproteção, corticosteróides tópicos e antimaláricos. Imunossupressores, talidomida, dapsona e retinóides podem ser usados nos casos refratários. CONCLUSÕES: O LED da infância parece ter pequeno predomínio no gênero feminino, alta prevalência de história familiar de lupus eritematoso e elevada proporção que evolui para a forma sistêmica da doença, comparada ao LED do adulto. O LED localizado e o generalizado apresentam prognósticos semelhante. Os achados histológicos não foram diferentes daqueles descritos no LED do adulto.OBJECTIVE: To review the literature about discoid lupus erythematosus (DLE in childhood. DATA SOURCES: Textbooks and journals indexed for Medline and SciELO in the last ten years. The following key-words were

  4. Diagnóstico laboratorial das leucemias mielóides agudas

    OpenAIRE

    Silva,Graziele C. da; Pilger,Diogo A.; Castro,Simone M. de; Wagner,Sandrine C.

    2006-01-01

    As leucemias agudas caracterizam-se pela proliferação clonal e pelo bloqueio maturativo das células hematopoéticas, com substituição difusa da medula óssea por células neoplásicas. A leucemia mielóide aguda (LMA) é um grupo heterogêneo de doenças clonais do tecido hematopoético, que acomete predominantemente idosos acima de 60 anos de idade. A LMA apresenta oito subtipos distintos morfologicamente: LMA M0 a M7. Os métodos diagnósticos para identificação da LMA e classificação dos subtipos são...

  5. Hemangioendotelioma epitelióide de pleura Epithelioid hemangioendothelioma of the pleura

    OpenAIRE

    Patrícia K. Vitório; Ester M. Coletta; Nelson Morrone; Carlos H. Lima; Guilherme J. Costa; Daniel Inoue; Fabiam B. Hernandes

    2004-01-01

    Relata-se o caso de um paciente exposto profissionalmente a asbesto por dez anos e portador de um tumor pleural muito raro, o hemangioendotelioma epitelióde. O paciente apresentava derrame pleural serohemorrágico, sem evidência de células neoplásicas e com predomínio de linfócitos. A biópsia pleural por agulha revelou processo inflamatório crônico inespecífico, com áreas de tecido mixóide. A videotoracoscopia mostrou nódulos difusos nas pleuras parietal e visceral. A biópsia revelou neoplasia...

  6. Estudo micro-mesoscópico das granulações aracnóides humanas

    OpenAIRE

    Marcílio Hubner de Miranda Neto; Walter Biazoto; Renato Paulo Chopard; Guilherme Araújo Lucas

    1990-01-01

    A anatomia funcional das granulacões aracnóides do seio sagital superior foi estudada por técnicas micro-mesoscópicas a fim de contribuir para esclarecimentos de vias de drenagem do liqüido cerebrospinal através de seus componentes fibrosos. A disposição dos elementos fibrosos foi analisada na base do pedículo, pedículo, centro e ápice da granulação. A análise dos cortes seriados mostra na base do pedículo, malhas de colágeno com morfologia predominantemente circular orientando-se longitudina...

  7. Paratireóides: estrutura, funções e patologia

    OpenAIRE

    Prospero,José Donato de; Baptista,Pedro Pericles Ribeiro; Amary,Maria Fernanda Carriel; Santos,Priscila Pizzo Crêm dos

    2009-01-01

    Os autores tecem considerações sobre a estrutura e funções normais das glândulas paratireóides como introdução à patologia e as repercussões clinico - patológicas tanto do excesso como da redução do paratormônio. Maior ênfase é dedicada ao hiperparatireoidismo primário quanto às causas, a fisiopatologia das alterações, os aspectos anatomopatológicos macro e microscópicos das lesões e sua patogenia, na "Osteite fibrocistica" ou "doença de von Recklinghausen dos ossos" com a correlação aos aspe...

  8. Plexo coróide hipertrofiado (demonstrado angiogràficamente e hidrocefalia

    Directory of Open Access Journals (Sweden)

    Gilberto Machado de Almeida

    1964-12-01

    Full Text Available É discutido e mesmo pôsto em dúvida por alguns autores, o papel desempenhado pelo aumento de produção do líquido cefalorraqueano (LCR, na patogênese da hidrocefalia. No caso apresentado foram encontrados os seguintes elementos que indicam ser o aumento de produção do LCR a causa da hipertensão intracraniana: 1 hipertrofia dos plexos coróides sugerida pelas angiografias e confirmada pelo ato cirúrgico e necropsia; 2 ausência de bloqueio ao trânsito do LCR; 3 grande aumento do espaço subaracnói-deo, mais evidente ao nível das cisternas, inclusive inter-hemisférica e silviana.

  9. Tratamento das fraturas do processo odontóide Treatment of odontoid fractures

    Directory of Open Access Journals (Sweden)

    Pedro Augusto Pontin

    2011-01-01

    Full Text Available OBJETIVO: Este artigo faz a avaliação retrospectiva clínica e radiológica das fraturas do odontóide de 20 pacientes atendidos no IOT-HCFMUSP, durante o período de 2004-2010. MÉTODOS: Foi realizado a estratificação destas fraturas segundo sua classificação (AO/Anderson e D'Alonzo, perfil epidemiológico, tipo de tratamento, tempo de consolidação e complicações. RESULTADOS: Observou-se maior número de casos da fratura do odontóide em pacientes do sexo masculino (4:1, com idade entre 3ª e 4ª década de vida (60%, vítimas de quedas de altura (60% e acidentes automobilísticos (25% como principais mecanismos de trauma, e 15% dos casos apresentaram-se com déficit neurológico. A fraturas do odontóide de maior prevalência foram as do tipo II (55%, seguidas pelas fraturas do tipo III (40%. Os tratamentos mais empregados nas fraturas do tipo II e III foram, respectivamente, o cirúrgico (73% e conservador (87,5%. A consolidação ocorreu em até 16 semanas para 87,5% dos casos de tratamento cirúrgico e para 54,5% dos tratados conservadoramente. Não houve casos de pseudoartrose. CONCLUSÃO: O tratamento cirúrgico das fraturas do odontóide do tipo II apresentou resultados satisfatórios em relação ao tempo consolidação e baixa incidência de complicações, bem como o tratamento conservador destinado às fraturas do tipo III.Nivel de Evidência IV, série de casos.OBJECTIVE: This article describes a clinical and radiologic retrospective analysis of odontoid fractures in20 patients accompanied byThe IOT-HCFMUSP,from 2004 to 2010. METHODS: These fractures were stratified according to their classification (AO/Anderson andD'Alonzo, epidemiologic profile, type of treatment, time to consolidation of the fracture, and complications. RESULTS: It was observed that there was a higher number of odontoid fractures in males (4:1, between the third and fourth decades of life (60%, and that the main causes of the trauma were falling from

  10. Papel do Fator de Crescimento Endotelial Vascular nos Carcinomas de Tireóide

    Directory of Open Access Journals (Sweden)

    Clarissa Capp

    2009-04-01

    Full Text Available O crescimento tumoral está diretamente relacionado com a neovascularização, a qual decorre do desequilíbrio entre os fatores pró-angiogênicos e antiangiogênicos, secretados pelas células neoplásicas O fator de crescimento endotelial vascular (VEGF desempenha papel chave na angiogênese tumoral, estimulando a proliferação, migração e sobrevivência das células endoteliais. Atua através da ligação a receptores tirosina quinase específicos: VEGFR-1/Flt-1, VEGFR-2/KDR e VEGFR-3. O aumento da expressão do VEGF e de seus receptores tem sido associado à progressão, metastatização e pior prognóstico em diversos tumores malignos. A compreensão das vias moleculares que envolvem o mecanismo de indução da angiogênese tumoral por fatores de crescimento como o VEGF aumentam as possibilidades de novas terapêuticas a serem utilizadas no tratamento de tumores malignos humanos. Evidências indicam um importante papel do VEGF nas neoplasias da tireóide e a utilização de inibidores do VEGF ou de seus receptores pode constituir um importante recurso terapêutico, já tendo sido utilizado em determinados tipos de tumores humanos. O presente artigo tem como objetivo fazer uma revisão da atuação do VEGF no crescimento tumoral com enfoque nas neoplasias malignas da tireóide.

  11. Artrite reumatóide: diagnóstico e tratamento

    Directory of Open Access Journals (Sweden)

    IMM Laurindo

    2004-12-01

    Full Text Available DESCRIÇÃO DO MÉTODO DE COLETA DE EVIDÊNCIAS: Reunião consensual e multidisciplinar com a participação de médicos reumatologistas, fisiatra e ortopedista para elaboração do texto final. O texto inicial tomou por base o documento do Colégio Americano de Reumatologia "Guidelines for the management of rheumatoid arthritis" e também o texto das "Diretrizes do Ministério da Saúde para o Diagnóstico e Tratamento da Artrite Reumatóide", acrescido da experiência de reumatologistas, e complementado por extensa revisão bibliográfica, com prioridade para meta-análises. Os participantes, divididos em três grupos, produziram o texto básico, cujas recomendações foram submetidas à revisão e à aprovação pelo conjunto dos participantes. Depois, disponibilizados na internet, foi objeto de novas sugestões por parte de outros especialistas, até alcançar a forma final. GRAU DE RECOMENDAÇÃO E FORÇA DE EVIDÊNCIA: A: Estudos experimentais e observacionais de melhor consistência. B: Estudos experimentais e observacionais de menor consistência. C: Relatos de casos (estudos não controlados. D: Opinião desprovida de avaliação crítica, baseada em consensos, estudos fisiológicos ou modelos animais. OBJETIVOS: Estabelecer diretrizes claras e sucintas para o diagnóstico e tratamento da artrite reumatóide. CONFLITO DE INTERESSE: Os autores Laurindo IMM, Ximenes AC, Lima FAC, Pinheiro GRC, Bertolo MB, Xavier RM, Ciconelli RM e Radominski SC declararam vínculo com a Indústria Farmacêutica.

  12. Growth of Coxiella burnetii in the Ixodes scapularis-derived IDE8 tick cell line.

    Science.gov (United States)

    Herrin, Brian; Mahapatra, Saugata; Blouin, Edmour F; Shaw, Edward I

    2011-07-01

    Q fever, a zoonotic disease, is caused by a gram-negative intracellular bacterium, Coxiella burnetii. Although normally transmitted during exposure to infectious aerosols, C. burnetii is also found in arthropod vectors. In the environment, ticks are thought to play a crucial role in bacterial maintenance and transmission by infecting various mammalian species. However, the nature of the pathogen-tick relationship is not well defined. To determine C. burnetii's interactions with a cultured tick cell line, we introduced purified C. burnetii NMII into Ixodes scapularis-derived IDE8 cells and assayed for bacterial presence, replication, gene expression, and subsequent infectivity for mammalian cells. Tick cells were harvested at 24 h, 72 h, 7 days, and 11 days postinfection (PI). C. burnetii uptake and subsequent replication was demonstrated by indirect immunofluorescence assay, electron microscopy, and real-time polymerase chain reaction (PCR). When a genome equivalent multiplicity of infection of 30 was used, 30%-40% of exposed cells were seen to have small, rounded, vacuoles at 72 h PI, whereas at 7 and 11 days PI, 60%-70% of cells contained enlarged vacuoles harboring large numbers of bacteria. Quantitative PCR analysis of total genomic DNA confirmed that C. burnetii genome numbers increased significantly from 24 h to 11 days PI. Expression of C. burnetii type four secretion system homologs at 7 days PI was demonstrated by reverse transcriptase PCR. Finally, indirect immunofluorescence assay demonstrated that C. burnetii propagated within IDE8 cells were infectious for mammalian cells. These studies demonstrate the utility of cultured tick cell lines as a model to investigate C. burnetii's molecular interactions with its arthropod vectors.

  13. Movimento quântico e semiclássico no campo de um magnético-solenóide

    OpenAIRE

    Damião Pedro Meira Filho

    2010-01-01

    Um novo procedimento para construir os estados coerentes (CS) e os estados semiclássicos (SS) no campo de um magnético-solenóide é proposto. A idéia principal é baseada sobre o fato de que o AB solenóide quebra a simetria translacional no plano-xy, isto apresenta um efeito topológico tal que surgem dois tipos de trajetórias, aquelas que circundam e aquelas que não circundam o solenóide. Devido a este fato, deve-se construir dois tipos diferentes dos CS/SS, os quais correspondem as referidas t...

  14. Tumor marrom em esterno: uma causa potencial de resultado falso-positivo na cintilografia das paratireóides com sestamibi-99mTc

    OpenAIRE

    Duarte, Paulo Schiavom; Domingues, Fernanda C.; Costa, Michele Santi; Brandão, Cynthia; Oliveira, Marco A.C. de; Vieira, José G.H.

    2007-01-01

    A cintilografia das paratireóides tem sido utilizada para detectar glândulas patológicas em pacientes com hiperparatireoidismo, tanto antes quanto após a cirurgia de paratireoidectomia. Apesar da elevada especificidade, a cintilografia das paratireóides pode apresentar resultados falso-positivos. Neste artigo, relatamos o caso de uma paciente transplantada renal, com múltiplas lesões osteolíticas na bacia, interpretadas como tumores marrons, que à cintilografia das paratireóides com sestamibi...

  15. 77 FR 70168 - Guidance for Industry and Food and Drug Administration Staff; The Content of Investigational...

    Science.gov (United States)

    2012-11-23

    ...; The Content of Investigational Device Exemption and Premarket Approval Applications for Artificial... Content of Investigational Device Exemption (IDE) and Premarket Approval (PMA) Applications for Artificial... single copies of the guidance document entitled ``The Content of Investigational Device Exemption (IDE...

  16. Carotenóides como alternativa contra a hipovitaminose A Carotenoids as an alternative against hypovitaminosis A

    Directory of Open Access Journals (Sweden)

    Carmem Lygia Burgos Ambrósio

    2006-04-01

    Full Text Available A hipovitaminose A acarreta xeroftalmia, cegueira e morte em milhares de crianças no mundo e constitui um dos principais problemas nutricionais de populações de países em desenvolvimento, incluído o Brasil. Embora haja grande disponibilidade de frutas e verduras, fontes de carotenóides no Brasil, a hipovitaminose A constitui um grave problema de saúde pública. A falta de informação da população, no que diz respeito às fontes alimentares e aos fatores que interferem na biodisponibilidade dos carotenóides, citados na literatura, com a "mnemônica" SLAMENGHI são possíveis causas associadas a esta contradição. Os atuais fatores de conversão de carotenóides em retinol são superiores aos antigos fatores, o que pressupõe uma efetividade ainda menor na conversão dos carotenóides na forma ativa da vitamina A e coloca em questão a utilização destes no combate à hipovitaminose A. Esta revisão tem como objetivo relatar o que vem sendo abordado acerca do tema biodisponibilidade e fontes de carotenóides, para possibilitar um melhor posicionamento na utilização dos carotenóides no combate à hipovitaminose A.Hypovitaminosis A causes xerophthalmia, blindness and death in thousands of children throughout the world and constitutes one of the main nutritional problems in the populations of developing countries, including Brazil. Although fruits and vegetables, sources of carotenoids, are widely available in Brazil, hypovitaminosis A constitutes a serious public health problem. The lack of information available to the population about the dietary sources of carotenoids and factors affecting their bioavailability, known in the literature as SLAMENGHI, are possible causes associated with this contradiction. Current carotenoid conversion factors to retinol are higher than earlier ones. This suggests a reduced effectiveness in the conversion of carotenoids into the active form of vitamin A, questioning the role of carotenoids in

  17. Termoterapia transpupilar em melanoma maligno da coróide Transpupillary thermotherapy for malignant choroidal melanoma

    Directory of Open Access Journals (Sweden)

    Martha M. Motomo Chojniak

    2001-04-01

    Full Text Available Objetivo: Vários métodos vem sendo utilizados para o tratamento dos melanomas da coróide. A proposta deste trabalho preliminar é avaliar a eficácia da termoterapia transpupilar (TTT como tratamento primário de melanomas da coróide pequenos. Métodos: Foi realizado um trabalho prospectivo e não-randomizado para avaliar os aspectos clínicos, resposta do tumor, complicações e resultados visuais de pacientes portadores de melanomas da coróide pequenos (até 4,0 mm de espessura e 12 mm de diâmetro basal tratados por termoterapia transpupilar utilizando-se sucessivas aplicações de laser diodo contínuo de 810 nm. Resultados: Foram tratados 11 pacientes portadores de melanomas da coróide pequenos. O tumor era único e pigmentado em 100% dos casos. Crescimento documentado esteve presente em 5 pacientes (45,45% previamente ao tratamento e fatores de risco para crescimento ou metástase estavam presentes em todos os pacientes. O tempo de seguimento destes pacientes a partir do tratamento foi em média de 5,72 meses (3 - 8 meses. Foram utilizadas 3 sessões de laser em 5 pacientes (45,45% e 4 sessões em 6 pacientes (64,64%. As lesões apresentavam, por ocasião do diagnóstico, uma espessura média de 2,65 mm (1,85-3,86 mm, com maior diâmetro basal médio de 7,98 mm (4,2-11,33 mm. Após o tratamento, a espessura média foi de 1,83 mm (0,98-2,93 mm e o maior diâmetro basal médio foi de 6,59 mm (3,81 mm -10,67 mm. Das lesões tratadas, 100% apresentaram diminuição da altura e do máximo diâmetro basal, tendo sido a diminuição média da espessura de 0,89 mm e do máximo diâmetro basal de 1,39 mm. A acuidade visual manteve-se inalterada em 5 casos (45,45% e piorou após o tratamento em 6 casos (54,54%. Ocorreram complicações em 9 casos, tendo sido considerada complicação grave 1 caso de descolamento parcial da retina (9,09%; as outras complicações foram consideradas leves: pequenas hemorragias intra-retinianas em 7 pacientes (63

  18. Nódulo reumatóide intermetatarsal com sintomas de neuroma de Morton: diagnóstico diferencial Intermetatarsal rheumatoid node with Morton's neuroma signs: differential diagnosis

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Flores dos Santos

    2004-12-01

    Full Text Available Paciente do sexo feminino, com 38 anos de idade, portadora de artrite reumatóide ( AR , com dor intermetarsal no 3º espaço, em ambos os pés, com parestesia dos 3º e 4º dedos. Operada para ressecção de massas hipoecóicas evidenciadas por ecografia. O exame anátomo-patológico definiu degeneração fibrinóide e mixóide ( nódulo reumatóide .A 38 years old female pacient, in treatment by rheumatoid arthritis (RA, with pain in the 3º intermetatarsal space and paresthesia in the 3º toe, bilateral. She was operated for resection of hipoechoicsmasses showed in echographic examination. The anatomopathologic diagnosis was fibrinoid and mixoid degeneration ( rheumatoid nodule.

  19. Adenoma de paratireóide e o hiperparatiroidismo primário

    Directory of Open Access Journals (Sweden)

    Mariana Fidelis Solla

    2015-10-01

    Full Text Available O Hiperparatiroidismo Primário (HPP é uma doença metabólica queresulta no excesso de secreção de paratormônio (PTH e é geralmente causadopela presença de um adenoma de paratireoide. Os níveis elevados de PTH são oachado laboratorial mais importante para o diagnóstico da doença. O HPP pode seapresentar de forma assintomática ou então na forma de doença óssea peloexcesso de PTH, que aumenta a reabsorção óssea; litíase renal pelahipofosfatemia e a hipercalciúria ou crise paratiroidea. Objetivos: Relatar o casodo paciente do Hospital Santa Lucinda que foi submetido à retirada cirúrgica deadenoma de paratireóide causador de HPP. Metodologia: As informações contidasnesse trabalho foram obtidas por meio de análise de prontuário e revisão deliteratura. Relato de caso: Paciente masculino, 28 anos, chegou ao CHS comfratura em fêmur direito e em úmeros direito e esquerdo após cair e apoiar-se paralevantar. Possui história pregressa de litíase renal há 9 anos, há 6 anos e há 1 anoe meio; há 11 meses fraturou um arco costal à direita após sua companheiraapoiar-se em seu tórax e há 3 meses fraturou o úmero esquerdo ao apoiar-se paralevantar. Aos exames laboratoriais apresentou: cálcio total = 14,6 mg/dL; cálcioiônico = 7,6 mg/dL; fosfatase alcalina = 494U/L; albumina = 4,1 g/dL; creatinina =1,9 mg/dL (depuração da creatinina endógena estimada em 72 mL/minuto;paratormônio intacto = 327 pg/mL. A ultrassonografia de glândula tireóide revelou apresença de nódulo sólido hipoecóico em lobo direito inferior da glândulaparatireoide. O paciente foi submetido a paratireoidectomia parcial e oanatomopatológico da peça cirúrgica evidenciou um quadro histológico compatívelcom adenoma de paratireóide. Conclusão: O diagnóstico de HPP depende dosníveis séricos de cálcio bem como a avaliação de outras apresentações atípicas,como a litíase renal. O tratamento é a retirara das glândulas , atrav

  20. Nódulos linfóides medulares Bone marrow lymphoid nodules

    Directory of Open Access Journals (Sweden)

    Silvia M. M. Magalhães

    2003-06-01

    Full Text Available A biópsia de medula óssea é parte integrante do estadiamento e seguimento de pacientes com doenças hematológicas. Nódulos linfóides são um achado comum, usualmente observados em associação com doenças inflamatórias crônicas, infecção, hemólise, síndromes mieloproliferativas e doenças auto-imunes. São, em geral, considerados reacionais. Sendo a medula óssea o sítio extranodal mais comumente envolvido nos linfomas foliculares, o diagnóstico diferencial mais importante é a infiltração medular por doença linfoproliferativa. Do ponto de vista prático, os infiltrados linfóides são, em geral, facilmente distinguíveis ao estudo histológico. Agregados reacionais são pequenos, têm bordas delimitadas, são compostos por uma população celular heterogênea e têm localização central. Nódulos malignos infiltram a medula óssea na região paratrabecular e são compostos por células clivadas. A análise imunofenotípica, utilizando um painel de anticorpos monoclonais, é capaz de definir a linhagem celular, subpopulação e estágio de diferenciação da população neoplásica, contribuindo para a confirmação do diagnóstico. Nos casos controversos, a análise molecular da proliferação linfóide pode ser útil. A monoclonalidade pode ser demonstrada pela restrição de cadeias leves ou através do rearranjo do DNA da cadeia pesada das imunoglobulinas. Idealmente, os resultados da análise molecular devem ser interpretados em conjunto com a análise morfológica e imunofenotípica. A morfologia continua sendo o padrão-ouro na avaliação da infiltração medular por linfoma folicular e as análises imunofenotípica e molecular devem ser consideradas complementares.Bone marrow trephine biopsies are an integral part of the diagnosis, staging and follow-up of patients with haematologic disorders. Lymphoid nodules are a common finding, usually reported in association with chronic inflammatory syndromes, infection

  1. 76 FR 51431 - Prohibited Transaction Exemptions and Grant of Individual Exemptions

    Science.gov (United States)

    2011-08-18

    ... Carpenters Pension Fund, 2011-15; L-11651 and L-11652, Verizon Communications, Inc. and Cellco Partnership... Carpenters Pension Fund (the Plan),'' replace the bracketed text ``[Prohibited Transaction Exemption 2011-11...

  2. Public service quality improvements: a case for exemption from IRB review of public administration research.

    Science.gov (United States)

    Jordan, Sara R

    2014-01-01

    Should the exemption from Institutional Review Board (IRB) evaluations currently in place for quality improvements research be extended to public administration research that addresses questions of improving the quality of public service delivery? As a means to both reduce the level of disdain held by a group of social science researchers for IRBs and to reduce the cost of review for minimal risk studies, I argue here that much of the current public administration research should also be exempted from normal processes of review by IRBs on the basis of their similarity to Quality Improvements (QI) research, a category of studies already granted exemption. This argument dovetails provisions currently in place for studies of public service and public benefit, but reframes these exemptions in the language of "quality improvements," which may be a more comfortable language for IRBs concerned to demonstrate compliance for review of all fields. To expedite this argument into the practices of IRBs, I included a checklist that researchers could use to self-identify their studies as QI, not research as such.

  3. THE INFLUENCE OF JOB SATISFACTION AND LEADERSHIP STYLE ON ORGANIZATIONAL CITIZENSHIP BEHAVIOR (STUDY AT PT IDE JAYA KREASINDO

    Directory of Open Access Journals (Sweden)

    Bagus Tri Pratikto

    2015-09-01

    Full Text Available The purpose of this study is : 1 To know the description of job satisfaction and the leadership style on Organizational Citizenship Behavior (Study at PT Ide Jaya Kreasindo 2 To know the effect of job satisfaction on Organizational Citizenship Behavior 3 To know the effect of the leadership style on Organizational Citizenship Behavior 4 To know the effect of job satisfaction and the leadership style on Organizational Citizenship Behavior simultaneously. Research methods using simple random sampling. Sampling technique using simple random sampling technique and of questionnaires of 77 observations from PT Ide Jaya Kreasindo’s employees using SPSS 16.0.The empirical result shows that job satisfaction and the leadership style has positive and significant effect on organizational citizenship behavior. Simultaneously test shows that job satisfaction and the leadership style effects organizational citizenship behavior.

  4. Influência dos abusos estudantis durante os festejos académicos nos espermatozóides

    OpenAIRE

    Almeida, Ana Karina Lopes

    2012-01-01

    Dissertação de mestrado em Biologia, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra A espermatogénese e a espermiogénese são processos complexos de divisão e diferenciação celular, respectivamente, cujo principal objectivo é gerar espermatozóides capazes de fecundar o gâmeta feminino, o ovócito. O número de espermatozóides produzidos diariamente é uma medida da eficácia da espermatogénese. Este processo envolve três fases fu...

  5. Osteoma osteóide de acrômio que simula dor acrômio-clavicular

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2014-01-01

    Full Text Available O osteoma osteóide é um tumor ósseo benigno que se apresenta geralmente em adultos jovens com dor noturna, aliviada por repouso e anti-inflamatórios. Pode acometer qualquer osso. Entretanto, sua ocorrência no acrômio é rara. Os autores descrevem um caso de osteoma osteóide localizado no acrômio, com sintomas que simulavam artrose acrômio-clavicular. O diagnóstico foi feito por meio de tomografia computadorizada e o tratamento proposto foi a exérese do nidus por meio de artroscopia. O diagnóstico definitivo foi confirmado por exame histopatológico. No segmento ambulatorial, a paciente permaneceu assintomática e com recuperação completa da função do membro acometido.

  6. Carcinoma adenóide cístico: relato de caso = Adenoid cystic carcinoma: case report

    Directory of Open Access Journals (Sweden)

    Palmeiro, Mariana Reuter

    2005-01-01

    Full Text Available O carcinoma adenóide cístico é uma neoplasia maligna rara de crescimento lento, caracterizado prognóstico reservado, devido a sua agressividade e grande potencial recidivante. A lesão é mais prevalente em pacientes na faixa etária entre 50 e 70 anos, sendo incomum em jovens. O artigo relata um caso de carcinoma adenóide cístico de glândulas salivares menores localizado no palato duro em pacientes com 26 ano, do sexo masculino que foi encaminhado para tratamento no Serviço de Cirurgia de Cabeça e Pescoço

  7. Polymer Exemption for New Chemicals under the Toxic Substances Control Act (TSCA)

    Science.gov (United States)

    EPA has established an exemption for certain polymers to encourage manufacturers to make safer polymers. To learn more about this exemption, eligibility, and it's requirements, read this overview of the exemption.

  8. Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars.

    Science.gov (United States)

    Holm, Regina; Weber, Benjamin; Heller, Philipp; Klinker, Kristina; Westmeier, Dana; Docter, Dominic; Stauber, Roland H; Barz, Matthias

    2017-06-01

    Star-like polymers are one of the smallest systems in the class of core crosslinked polymeric nanoparticles. This article reports on a versatile, straightforward synthesis of three-arm star-like polypept(o)ide (polysarcosine-block-polylysine) polymers, which are designed to be either stable or degradable at elevated levels of glutathione. Polypept(o)ides are a recently introduced class of polymers combining the stealth-like properties of the polypeptoid polysarcosine with the functionality of polypeptides, thus enabling the synthesis of materials completely based on endogenous amino acids. The star-like homo and block copolymers are synthesized by living nucleophilic ring opening polymerization of the corresponding N-carboxyanhydrides (NCAs) yielding polymeric stars with precise control over the degree of polymerization (Xn = 25, 50, 100), Poisson-like molecular weight distributions, and low dispersities (Đ = 1.06-1.15). Star-like polypept(o)ides display a hydrodynamic radius of 5 nm (μ2 star-like polysarcosines and polypept(o)ides based on disulfide containing initiators are stable in solution, degradation occurs at 100 × 10(-3) m glutathione concentration. The disulfide cleavage yields the respective polymeric arms, which possess Poisson-like molecular weight distributions and low dispersities (Đ = 1.05-1.12). Initial cellular uptake and toxicity studies reveal that PeptoStars are well tolerated by HeLa, HEK 293, and DC 2.4 cells. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Concomitância da tireoidite de Hashimoto e o carcinoma diferenciado da tireóide

    Directory of Open Access Journals (Sweden)

    Alexandre Roberti

    Full Text Available OBJETIVO: Avaliar a associação da tireoidite auto-imune e o carcinoma diferenciado da tireóide na Santa Casa de Misericórdia de Goiânia-Goiás. MÉTODO: De 1395 tireoidectomias realizadas de 1994 a 2003, foram selecionadas 120 carcinomas diferenciados (27 foliculares e 93 papilíferos. Foram avaliadas as variáveis clínicas (idade e sexo com apresentação de freqüências e de sumários de medidas-resumo na descrição estatística. Para aferir a associação de tireoidite auto-imune e carcinoma diferenciado da tireóide em função dos achados histopatológicos, utilizou-se tabelas de contingência e análise pelo teste não paramétrico do quiquadrado de Pearson. Em todos os testes estatísticos foi adotado um nível de significância de 5% (p<0,05. RESULTADOS: 11,1% dos carcinomas foliculares e 18,3% dos carcinomas papilíferos estão associados à tireoidite auto-imune. Existe uma relação de freqüências quatro vezes maior da tireoidite auto-imune com o carcinoma diferenciado da tireóide em comparação com outras doenças tireoideanas (16,7% X 3,6%. CONCLUSÕES: Tais resultados permitem inferir que a associação entre a tireoidite auto-imune e o carcinoma diferenciado da tireóide é mais que casual, exigindo uma observação clínico-laboratorial cuidadosa nos portadores da doença auto-imune.

  10. Nódulos reumatóides pulmonares precedendo o aparecimento de artrite Pulmonary rheumatoid nodules preceding arthritis development

    Directory of Open Access Journals (Sweden)

    José Eduardo Martinez

    2008-02-01

    Full Text Available A artrite reumatóide é uma doença sistêmica, de causa desconhecida e de natureza auto-imune. A característica clínica principal é a poliartrite crônica, em geral envolvendo pequenas e grandes articulações, com tendência a deformidades e incapacidades. A presença de nódulos subcutâneos pode ser parte da apresentação clínica e tem histopatologia típica. O comprometimento visceral pode incluir os pulmões, vasos, pericárdio etc. O envolvimento pulmonar pode se apresentar com derrame pleural, bronquiolite, vasculite pulmonar e mais raramente nódulos reumatóides. O desenvolvimento clássico é o dos envolvimentos viscerais após o aparecimento da artrite. Os nódulos reumatóides pulmonares têm baixa prevalência. Seu desenvolvimento precedendo a artrite acrescenta interesse ao assunto. Relata-se um caso de paciente do sexo feminino com nodulose reumatóide pulmonar que precedeu o envolvimento articular.Rheumatoid arthritis is a systemic disease of unknown cause and autoimune disease mechanisms. Its main clinical feature is a chronic polyarthritis involving large and small joints that may cause deformities and disabilities. Subcutaneous nodules can be part of the clinical presentation with a typical pathological appearance. Visceral involvement may include lungs, pericardium, and blood vessels. Pulmonary involvement is characterized by pleural effusions, vasculitis, bronchiolitis and pulmonary rheumatoid nodules. Usually, visceral manifestations appear after arthritis development. Pulmonary rheumatoid nodules are a rare feature. Its development preceding arthritis make this characteristic even more interesting. Our case report refers to a female patient with pulmonary rheumatoid nodules that has preceded the arthritis.

  11. Tratamento da febre tifóide pela as sociação de sulfametoxazol e trimetroprim

    Directory of Open Access Journals (Sweden)

    Guido Carlos Levi

    1970-06-01

    Full Text Available Usando associação de sulfametoxazol e trimetoprim, trataram os autores sete pacientes com febre tifóide. Os resultados obtidos foram considerados muito satisfatórios e comparáveis com os proporcionados pelo emprego do cloranfenicol. Julgaram os autores conveniente e oportuno realizar novas investigações sôbre o assunto, especialmente com a finalidade de estabelecer as posologias mais apropriadas.

  12. Epidermólise bolhosa albopapulóide (variante de Pasini Albopapuloid epidermolysis bullosa (Pasini's variant

    Directory of Open Access Journals (Sweden)

    Letícia Pereira Spinelli

    2003-08-01

    Full Text Available A epidermólise bolhosa albopapulóide é doença rara, de caráter autossômico dominante, também conhecida como epidermólise bolhosa distrófica albopapulóide de Pasini. Os autores relatam o caso de uma paciente de 37 anos de idade, com início do quadro aos sete anos, com lesões bolhosas e milia nas áreas de traumatismo, além de máculas hipocrômicas e atróficas (lesões albopapulóides no corpo. A paciente também apresenta pele apergaminhada, xerótica, e distrofia ungueal dos pés. A histopatologia da lesão bolhosa revelou clivagem subepidérmica, compatível com o diagnóstico clínico.Albopapuloid epidermolysis bullosa (Pasini's variant is a rare, autosomal dominant inherited disorder. The authors report the case of a 37-year-old female patient with blisters on trauma areas, atrophic macules (albopapuloid lesions and milia, with onset of disease at age seven. The histopathological exam of the blister reveals a subepidermal cleavage.

  13. Associação entre sintomas de insônia e artrite reumatóide em idosos

    Directory of Open Access Journals (Sweden)

    Denise Cuoghi de Carvalho Verissimo Freitas

    2013-08-01

    Full Text Available Esse estudo objetivou avaliar sintomas de insônia em idosos residentes na comunidade e sua associação com a artrite reumatóide. Estudo descritivo, de corte transversal, recorte do projeto multicêntrico Fragilidade em Idosos Brasileiros . Foram avaliados 689 idosos (68,9% mulheres, média de idade 72,2 anos utilizando-se questionário sociodemográfico e sobre condições clínicas, questões sobre sintomas de insônia (Perfil de Saúde de Nottingham e teste de rastreio para alterações cognitivas (Mini-exame do Estado Mental. Utilizou-se análise descritiva e análise de regressão logística múltipla, com nível de significância de 5%. A associação entre sintomas de insônia e artrite reumatóide manteve-se significativa na análise multivariada; outros fatores associados foram avaliação subjetiva da saúde muito ruim, não ser aposentado e apresentar depressão. Os profissionais da área da saúde devem investigar cuidadosamente a qualidade do sono noturno dos idosos acometidos por artrite reumatóide, dada sua elevada prevalência nessa população.

  14. ADMINISTRAÇÃO EPIDURAL DE OPIÓIDES EM CÃES EPIDURAL OPIOIDS ADMINISTRATION IN DOGS

    Directory of Open Access Journals (Sweden)

    Carlos Augusto Araújo Valadão

    2002-04-01

    Full Text Available Os opióides têm sido utilizados em Medicina Veterinária há vários anos como alternativa para o alívio da dor pós-operatória ou traumática. Atualmente, tem-se dado maior valor ao controle da dor nos animais, visando a oferecer melhores condições de recuperação ao paciente traumatizado ou recém-operado. A morfina foi o primeiro opióide usado em animais. Mais recentemente, a administração dessa substância, por via epidural, vem sendo empregada no controle da dor com resultados promissores. Assim, nesta revisão, abordam-se vários aspectos referentes aos efeitos e às indicações da administração epidural de opióides em cães.Opioids have been used for several years to relieve traumatic pain in Veterinary Medicine. The painful stimulus are implicated with delayed tissue recuperation of surgical wounds. Today, a great importance has been given to pre-emptive control of post operative pain in animals. Indeed, the use of epidural morphine, the first opioid substance used in animals, has provided excellent analgesia and good condition at the immediate post operative period. In addition, several aspects concerning the effects indications and forms of epidural opioids injections in dogs are considered in this review.

  15. Efeito de baixas doses de irradiação nos carotenóides majoritários em cenouras prontas para o consumo Effect of low doses of irradiation on the carotenoids in read-to-eat carrots

    Directory of Open Access Journals (Sweden)

    Keila S. Cople Lima

    2004-06-01

    Full Text Available O presente estudo teve como objetivo avaliar o efeito das baixas doses da radiação gama na concentração de carotenóides totais, alfa e beta-caroteno em cenouras minimamente processadas, durante a vida-útil. As cenouras são as principais fontes de carotenóides provitamínicos A (alfa e beta-caroteno de origem vegetal. De acordo com a Pesquisa de Orçamento Familiar (POF realizada na região Sudeste do Brasil, no grupo de raízes e tubérculos a cenoura é amplamente consumida. A estabilidade dos carotenóides varia grandemente durante o processamento e o armazenamento, dependendo de sua estrutura, temperatura, oxigênio, luz, umidade, atividade de água e presença de ácidos e metais antioxidantes e pró-oxidantes. As cenouras minimamente processadas neste experimento foram manualmente descascadas, lavadas, cortadas mecanicamente, acondicionadas em embalagens com atmosferas modificadas de 5% O2 / 10% CO2 e 21% O2 (ar sintético, tratadas com radiação ionizante gama, fonte de césio, nas doses de 0,25, 0,50, 0,75 e 1,00kGy, e armazenadas a 5°C durante 24 dias. Os carotenóides totais foram quantificados por espectrofotometria a 449nm. Para a determinação de alfa e beta-caroteno utilizou-se cromatografia líquida de alta eficiência (CLAE. Os diferentes tratamentos e o grupo controle foram, também, avaliados através das análises de cor e voláteis, por cromatografia gasosa/espectrometria de massas associada à microextração em fase sólida (CG-EM/MEFS, para estudar as perdas dos carotenóides durante o processamento.This study aims was to evaluate the effect of low doses of gamma radiation on the total carotenoids, alpha and beta-carotene content in minimally processed carrots, during the shelflife. Carrots are the mains vegetable source of carotenoids provitamin A (alpha and beta-carotene. According to the Family Budget Survey (FBS carried out in the Brazilian Southeast, within the roots and tubers group, carrots are widely

  16. Relações customizadas e o ideário de amor na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Ana Nascimento de Amorim

    2014-09-01

    Full Text Available A regra pós-moderna sugere ausência de discursos e práticas normatizadores, apontando ser possível a homens e mulheres não somente reproduzir modelos sociais, mas inventar formas de parcerias amorosas, o que chamamos de customizar as relações. Consideramos a diversidade das configurações conjugais coexistentes em nossa sociedade e a família moderna que permanece como modelo ideal para a maioria. A partir destas considerações, discutimos em que medida um casal homossexual feminino e um heterossexual das camadas médias de Belo Horizonte estariam repetindo valores mais próximos do modelo conjugal moderno e do ideário romântico, e/ou reinventando formas. Concluímos que a combinação dos ideais e valores assumidos pelos casais não só reflete a ideia de customização, pois cada casal assume um modo singular de se relacionar, como diz também de uma capacidade adaptativa aos nossos tempos.

  17. Condrossarcoma mixóide de átrio direito Right atrium myxoid chondrosarcoma

    Directory of Open Access Journals (Sweden)

    Cláudio Ribeiro da Cunha

    2008-03-01

    Full Text Available Relatamos o caso de uma paciente de 46 anos, cor branca, hipertensa há 20 anos, com suspeita de endocardite infecciosa. Foi realizado ecocardiograma transtorácico, o qual levou à hipótese de mixoma de átrio direito. A paciente foi submetida à cirurgia, observando-se massa tumoral de aspecto muco-gelatinoso friável. A massa foi submetida a congelação para exame anatomopatológico, com laudo sugestivo de tumor maligno mesenquimal. Foi realizado exame imunohistoquímico compatível com condrossarcoma mixóide. A paciente evoluiu com remissão espontânea do quadro após ressecção completa da neoplasia. Realizou acompanhamento ambulatorial por 14 meses, sem apresentar sinais de recidiva do tumor.We report a case of a 46 years-old woman, Caucasian, with hypertension and a primary dianosis of infectious endocarditis. A transthoracic echocardiogram was performed suggesting right atrium myxoma. The patient was submitted to surgery, which found a tumor mass with a jelly-like exterior. The mass was sent to anatomo-pathological analysis which diagnosed a myxoid chondrosarcoma tumor. After surgical resection, the patient achieved complete recovery with no signs of recidivation after 14 months.

  18. Fra ide til form – kreativitet som grundlag for ergoterapeutisk entreprenørskab

    DEFF Research Database (Denmark)

    Madsen, Jacob Østergaard

    2013-01-01

    I dette kapitel tages der udgangspunkt i, at kreativitet er en skabelse af noget nyt på baggrund af en erfaringsbaseret ide. For ergoterapeuter kan det for eksempel være et nyt hjælpemiddel, et nyt undersøgelsesredskab eller et nyt koncept, der privatiseres og markedsgøres – altså nye måder til...... at håndtere og udføre ergoterapeutiske ydelser i allerede kendte eller nye rammer. Endvidere anskues kreativitet i dette kapitel som frembragt med en vis mængde af intention og motivation for at løse et problem med efterfølgende omsætning af løsningen til koncepter eller produkter med potentiale...... for udbredelse til en større kreds af aftagere. Kreativitet skal i dette kapitel således ikke forstås som ubevidste, uovervejede og spontane handlinger, men nærmere som en velovervejet og begrundet spontanitet, der over tid har taget form i tankerne hos en eller flere ergoterapeuter. Kapitlet afsluttes med...

  19. 45 CFR 5b.11 - Exempt systems.

    Science.gov (United States)

    2010-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.11 Exempt systems... individual to be granted access to an accounting of disclosures of a record. (ii) 5 U.S.C. 552a(d) (1...; and, (D) The Maryland Psychiatric Case Register. (E) The Health Resources Utilization Statistics, DHHS...

  20. Allegheny County Clean Indoor Air Act Exemptions

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — List and location of all the businesses and social clubs who have received an exemption from the Pennsylvania Clean Indoor Air Act. “The Clean Indoor Air Act, Act...

  1. 21 CFR 710.9 - Exemptions.

    Science.gov (United States)

    2010-04-01

    ... REGISTRATION OF COSMETIC PRODUCT ESTABLISHMENTS § 710.9 Exemptions. The following classes of persons are not... organizations that compound cosmetic products at a single location and administer, dispense, or distribute them at retail from that location and who do not otherwise manufacture or package cosmetic products at...

  2. 24 CFR 1710.14 - Regulatory exemptions.

    Science.gov (United States)

    2010-04-01

    ... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements... the registration requirements of the Act unless the Secretary has terminated the exemption in... lessee to renew. (3) The sale of lots to a person who is engaged in a bona fide land sales business. (4...

  3. 7 CFR 984.67 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... walnuts in the area of production directly to consumers under the following types of exemptions. (i) At..., and volume regulations—(1) Sales by growers direct to consumers. Any walnut grower may handle walnuts... exceeding 10 pounds of inshell walnuts or 4 pounds of shelled walnuts to any one consumer in any one...

  4. 32 CFR 322.6 - Establishing exemptions.

    Science.gov (United States)

    2010-07-01

    ... deleted from the requested documents and the balance made available. The controlling principle behind this... the scope of Sec. 310.51(a). If an individual is denied any right, privilege or benefit that he or she... in personnel or administrative actions. (iii) (k)(3) exemption. Records maintained in connection with...

  5. 76 FR 69662 - Methacrylic Polymer; Tolerance Exemption

    Science.gov (United States)

    2011-11-09

    ... chemical formulation under 40 CFR 180.960. AkzoNobel Surface Chemistry LLC submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of...) filed by AkzoNobel Surface Chemistry LLC, 909 Mueller Ave., Chattanooga, TN 37406. The petition...

  6. 7 CFR 930.162 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Exemptions. 930.162 Section 930.162 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... shall include the manager (or a Board member acting in the Manager's stead), the public member and one...

  7. 46 CFR 176.920 - Exemptions.

    Science.gov (United States)

    2010-10-01

    ... CERTIFICATION International Convention for Safety of Life at Sea, 1974, as Amended (SOLAS) § 176.920 Exemptions. (a) In accordance with Chapter I (General Provisions) Regulation 4, of SOLAS, the Commandant may... regulations of SOLAS provided that the vessel complies with safety requirements that are adequate, in the...

  8. 32 CFR 316.8 - Exemptions.

    Science.gov (United States)

    2010-07-01

    ... some of the requirements of the act. This part reserves to the Director, DISA, as head of an agency... maintained by DISA shall be exempt from the requirements of 5 U.S.C. 552a (d) pursuant to 5 U.S.C. 552a(3)(k...

  9. 7 CFR 915.53 - Exemption certificates.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Exemption certificates. 915.53 Section 915.53 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA...

  10. 7 CFR 1219.8 - Exempt handler.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Exempt handler. 1219.8 Section 1219.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH...

  11. 7 CFR 930.62 - Exempt uses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Exempt uses. 930.62 Section 930.62 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements...) Export to designated destinations; (3) Experimental purposes; or (4) For any other use designated by the...

  12. Predicting Exemptions and Hardship in CISG Context

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    2016-01-01

    79 theory and practice, as well as the advent of a highly controversial conundrum: how to handle ‘hardship’ in the liability-exemptions context? By way of introduction to this particular CISG topic area, the author sketches the larger Sales Convention picture and its relationship to domestic law...

  13. 7 CFR 1205.519 - Organic exemption.

    Science.gov (United States)

    2010-01-01

    ... agent as defined in section 2103 of the Organic Foods Production Act of 1990 (7 U.S.C. 6502), a signed... for organic products, isolated use of antibiotics for humane purposes, chemical or pesticide use as... 7 Agriculture 10 2010-01-01 2010-01-01 false Organic exemption. 1205.519 Section 1205.519...

  14. 7 CFR 1260.302 - Organic exemption.

    Science.gov (United States)

    2010-01-01

    ... provided by a USDA-accredited certifying agent as defined in section 2103 of the Organic Foods Production.... Reasons for conventional sales include lack of demand for organic products, isolated use of antibiotics... 7 Agriculture 10 2010-01-01 2010-01-01 false Organic exemption. 1260.302 Section 1260.302...

  15. 7 CFR 1218.53 - Exemption procedures.

    Science.gov (United States)

    2010-01-01

    ... defined in section 2103 of the Organic Foods Production Act of 1990 (7 CFR part 205), a signed... for organic products, isolated use of antibiotics for humane purposes, chemical or pesticide use as... exemption is claimed. (c) A producer who operates under an approved National Organic Program (NOP) (7 CFR...

  16. Tax Exempt Status of Private Schools.

    Science.gov (United States)

    Manville, Phyllis

    1982-01-01

    Recounts actions of the Internal Revenue Service and the federal government from 1965 to 1982 involving tax exempt status and racially discriminatory schools. Traces federal court decisions on the issue since 1970, including "Green v. Connally" and current Supreme Court cases involving Bob Jones University (South Carolina) and Goldsboro…

  17. 16 CFR 423.8 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Exemptions. 423.8 Section 423.8 Commercial... the required care information for the product. However, the care information can be put on a hang tag... “wash or dry clean, any normal method” must appear on a hang tag, on the package, or in some other...

  18. 40 CFR 147.102 - Aquifer exemptions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Aquifer exemptions. 147.102 Section 147.102 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...) Granite Point. (ii) McArthur River Field. (iii) Middle Ground Shoal Field. (iv) Trading Bay Field. (3) The...

  19. 7 CFR 966.71 - Granting exemptions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Granting exemptions. 966.71 Section 966.71 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements.... Such certificate shall be transferred with such tomatoes at time of transportation or sale. ...

  20. 76 FR 70896 - Polyethylene Glycol; Tolerance Exemption

    Science.gov (United States)

    2011-11-16

    ... chemical formulation. Clariant Corporation submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation... pesticide inert ingredient in pesticide formulations as a solubilizer without limitations. That notice...

  1. 48 CFR 9904.402-62 - Exemption.

    Science.gov (United States)

    2010-10-01

    ... Section 9904.402-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.402-62 Exemption. None for this Standard. ...

  2. 48 CFR 9904.405-62 - Exemption.

    Science.gov (United States)

    2010-10-01

    ... Section 9904.405-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.405-62 Exemption. None for this Standard. ...

  3. 48 CFR 9904.401-62 - Exemption.

    Science.gov (United States)

    2010-10-01

    ... Section 9904.401-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.401-62 Exemption. None for this Standard. ...

  4. 48 CFR 9904.407-62 - Exemption.

    Science.gov (United States)

    2010-10-01

    ... Section 9904.407-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.407-62 Exemption. None for this Standard. ...

  5. 48 CFR 9904.406-62 - Exemption.

    Science.gov (United States)

    2010-10-01

    ... Section 9904.406-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.406-62 Exemption. None for this Standard. ...

  6. 48 CFR 9904.404-62 - Exemption.

    Science.gov (United States)

    2010-10-01

    ... Section 9904.404-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.404-62 Exemption. None for this Standard. ...

  7. 17 CFR 230.602 - Securities exempted.

    Science.gov (United States)

    2010-04-01

    ... just and equitable principles of trade; or (5) Is subject to a U.S. Post Office fraud order. (d) No... which is the subject of any proceeding or examination under section 8 of the Act, or is the subject of... Investment Company Act of 1940; or (7) Is subject to a U.S. Post Office fraud order. (c) No exemption under...

  8. 10 CFR 170.11 - Exemptions.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Exemptions. 170.11 Section 170.11 Energy NUCLEAR... licensing or safety issues, even though the NRC may realize some benefits from its review and approval of... educational institution for a production or utilization facility, other than a power reactor, or for the...

  9. 31 CFR 537.210 - Exempt transactions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Exempt transactions. 537.210 Section 537.210 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... personal and household effects set forth in §§ 537.511 and 537.514. ...

  10. 40 CFR 85.1705 - Testing exemption.

    Science.gov (United States)

    2010-07-01

    ...) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Exclusion and Exemption of Motor Vehicles and Motor Vehicle... the proposed test program exhibits a degree of control consonant with the purpose of the program and... vehicles or engines involved; and (e) With respect to control, the test program must incorporate procedures...

  11. 32 CFR 292.6 - FOIA exemptions.

    Science.gov (United States)

    2010-07-01

    ... INFORMATION ACT PROGRAM DEFENSE INTELLIGENCE AGENCY (DIA) FREEDOM OF INFORMATION ACT § 292.6 FOIA exemptions... footnote 1 to § 292.3(a)(3). 5 Forward requests to: Defense Intelligence Agency, ATTN: DSP-1A (FOIA... likely to cause substantial harm to the competitive position of the source providing the information...

  12. 32 CFR 518.13 - FOIA exemptions.

    Science.gov (United States)

    2010-07-01

    ..., 10 U.S.C. 128; (7) Protection of Intelligence Sources and Methods, 50 U.S.C. 403-3(c)(6); (8... is likely to cause substantial harm to the competitive position of the source providing the... to show competitive harm. If the information qualifies as exemption 4 information, there is no...

  13. 8 CFR 315.4 - Exemption treaties.

    Science.gov (United States)

    2010-01-01

    ... have effective treaties providing reciprocal exemption of aliens from military service: Argentina (Art. X, 10 Stat. 1005, 1009, effective 1853) Austria (Art. VI, 47 Stat. 1876, 1880, effective 1928) China (Art. XIV, 63 Stat. 1299, 1311, effective 1946) Costa Rica (Art. IX, 10 Stat. 916, 921, effective 1851...

  14. 44 CFR 6.86 - General exemptions.

    Science.gov (United States)

    2010-10-01

    ... Management Agency, to exercise the right to promulgate rules to exempt such systems in accordance with the... suspects or as subjects of a criminal investigation; this would compromise the ability of the Federal... criminal investigations and to detect or identify violators of laws administered by the Federal Emergency...

  15. 15 CFR 4.34 - Specific exemptions.

    Science.gov (United States)

    2010-01-01

    ...—COMMERCE/DEPT-14; and (ii) The foregoing are exempted from 5 U.S.C. 552a (c)(3), (d), (e)(1), (e)(4)(G), (H... Censuses—COMMERCE/ CENSUS-5; (E) Population Census Personal Service Records for 1900 and All Subsequent... Midshipman Personnel Files—COMMERCE/MA-18; (D) USMMA Non-Appropriated fund Employees—COMMERCE/MA-19; (E...

  16. 19 CFR 162.91 - Exemptions.

    Science.gov (United States)

    2010-04-01

    ... Border Protection or Immigration and Customs Enforcement officers except for those seizures of property... 19 Customs Duties 2 2010-04-01 2010-04-01 false Exemptions. 162.91 Section 162.91 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY...

  17. 40 CFR 69.11 - New exemptions.

    Science.gov (United States)

    2010-07-01

    ... of fuel oil with a sulfur content of 2.00 percent or less during offshore wind conditions. This fuel shall be fired in Cabras Power Plant Units Nos. 1 through 3 and in Piti Power Plant Units Nos. 4 and 5... Administrator of EPA conditionally exempts Guam Power Authority (“GPA”) from certain CAA requirements. (1) A...

  18. 50 CFR 679.6 - Exempted fisheries.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Exempted fisheries. 679.6 Section 679.6 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA General § 679.6...

  19. Divorce Rates and Bankruptcy Exemption Levels in the United States

    OpenAIRE

    Jeffrey Traczynski

    2011-01-01

    Although increasing bankruptcy exemption levels protects consumers from negative asset shocks, an unintended consequence of this policy that remains unexplored is the effect on divorce rates. This effect arises from reducing the benefits of marital risk sharing. I establish conditions under which increases in exemption levels lead to more divorce and investigate using data from Vital Statistics of the United States. I estimate that increases in exemption levels occurring between 1989 and 2005...

  20. Orbital myositis and rheumatoid arthritis: case report Miosite orbitária e artrite reumatóide: relato de caso

    Directory of Open Access Journals (Sweden)

    CLÁUDIA B. PANFILIO

    2000-03-01

    Full Text Available Orbital myositis implies orbital inflammation confined to one or more of the extraocular muscles. The acute form responds well to high doses of oral corticosteroids tapered gradually, but it may recur or become chronic. We describe a 38 years old female who has been suffering from rheumatoid arthritis for six years. She developed diplopia as a result of a paralysis of the right and left rectus medialis muscle. MRI showed inflammatory process and thickness of the referred muscles. The patient had a total recovery with oral use of 80 mg methylpredinisolone daily. Two months after the first episode she developed a bilateral ophthalmoplegy. The patient improved with oral use of steroids the second time, but a paresis of the left rectus lateralis muscle remained. From the 156 cases we reviewed only three have been related to rheumatic diseases and none has been previously related to rheumatoid arthritis.Miosite orbitaria é a inflamação de um ou mais músculos extraoculares. A forma aguda responde ao tratamento com doses altas de esteróides, porém pode-se tornar recorrente ou crônica. Relatamos uma paciente de 38 anos de idade, portadora de artrite reumatoide há 6 anos, que apresentou diplopia e cefaléia de um mês de evolução. A ressonância magnética (RM de órbitas mostrou processo inflamatório e espessamento dos músculos reto mediais. A paciente apresentou recuperação completa após o uso de 80 mg/dia de metilprednisolona. Dois meses depois, ela apresentou oftalmoplegia bilateral que acometia toda a musculatura ocular extrínseca. Desta vez, a RM foi normal. A paciente melhorou com nova série do esteroide, porém permaneceu com paresia do músculo reto lateral esquerdo como sequela. Revisamos 153 casos de miosite orbitaria publicados; apenas três estavam relacionados com doenças reumatológicas e nenhum deles com artrite reumatóide.

  1. 75 FR 24755 - DTE ENERGY; Enrico Fermi Atomic Power Plant Unit 1; Exemption From Certain Low-Level Waste...

    Science.gov (United States)

    2010-05-05

    ... COMMISSION DTE ENERGY; Enrico Fermi Atomic Power Plant Unit 1; Exemption From Certain Low-Level Waste Shipment Tracking Requirements In 10 CFR Part 20 Appendix G 1.0 Background DTE Energy (DTE) is the licensee.... DTE is in the process of decommissioning Fermi-1 and radioactive waste shipments from the site are...

  2. OPPORTUNITES FOR INCREASING EFFECTIVENESS OF SOCIAL ADAPTATION OF MILITARIES EXEMPTED OF MILITARY SERVICE

    Directory of Open Access Journals (Sweden)

    Venelin Terziev

    2014-09-01

    Full Text Available The monograph examines creation and verification of the theory of effective social adaptation of militaries exempted of military service and members of their families which to serve as a basis of the practical realization of a complex model of social adaptation in which models of social-psychological and social-pedagogical adaptation are adapted and a competence –based model is developed and substantiated aiming at increasing the efficiency of the adaptation process in the dynamic social environment.

  3. Isolamento de Arcanobacterium pyogenes de granuloma actinomicóide em bovino

    Directory of Open Access Journals (Sweden)

    Curcio Bruna da Rosa

    2002-01-01

    Full Text Available Foi observada em um bovino com suspeita de lechiguana, uma lesão arredondada de consistência dura na região sub-mandibular que media 12x11x7cm. Foram realizadas biópsias cirúrgicas para estudos bacteriológico e histológico, teste de tuberculinização intra-dérmico e coleta de sangue, a fim de realizar o teste de imunodifusão radial para o diagnóstico de lechiguana. Posteriormente, foi realizada eutanásia e necropsia do animal. No resultado das biópsias, não se obteve isolamento bacteriano e o estudo histológico não foi conclusivo. Os testes de tuberculinização e de imunodifusão apresentaram resultado negativo. Na necropsia, constatou-se que a lesão consistia de um nódulo, formado por uma cápsula de tecido conjuntivo envolvendo uma massa esbranquiçada com grânulos amarelados de até 3mm de diâmetro. Através de histologia, constataram-se piogranulomas multifocais, com um infiltrado de neutrófilos circundando rosetas formadas por colônias bacterianas no centro e corpúsculos de Splendore-Hoeppli na periferia; ao redor desse infiltrado purulento observaram-se células epitelióides e tecido fibroso infiltrado por linfócitos. Arcanobacterium pyogenes foi isolado em cultura pura do material obtido na necropsia. Conclui-se que A. pyogenes poderia ter participação na etiologia de granuloma com características clínicas e patológicas semelhantes à lechiguana, tuberculose e actinobacilose.

  4. Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts.

    Science.gov (United States)

    Lambiase, Pier D; Gold, Michael R; Hood, Margaret; Boersma, Lucas; Theuns, Dominic A M J; Burke, Martin C; Weiss, Raul; Russo, Andrea M; Kääb, Stefan; Knight, Bradley P

    2016-05-01

    The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a potential alternative to transvenous systems in hypertrophic cardiomyopathy (HCM) where lead complications are a significant issue. To compare the S-ICD efficacy of defibrillation threshold (DFT) testing, arrhythmia therapy, and complications in HCM versus non-HCM patients. Outcomes of patients with HCM implanted with S-ICD were compared to non-HCM S-ICD recipients using pooled data from a total of 872 subjects enrolled in the EFFORTLESS Registry and US IDE study. The cohort included 99 HCM (75% male) and 773 non-HCM (72% male) patients with a median follow-up of 637 days. The HCM cohort was younger and more likely to receive a primary-prevention S-ICD (88.5% vs 67.5%, P One year postoperative complication-free rates were similar: 92.7% in HCM (with no lead complications) versus 89.5% in non-HCM. There were 3 appropriate shocks for ventricular tachycardia in 3 HCM patients that were all converted by the first shock. Overall final shock conversion efficacy was 100% in HCM versus 98% in non-HCM (P = ns). Inappropriate shocks occurred in 12.5% of HCM patients and 10.3% of non-HCM patients (P = ns), being reduced by 47% using dual-zone programming. These initial data indicate the S-ICD is safe and effective in patients with HCM who are at high risk of ventricular arrhythmias and pass preimplantation electrocardiogram screening. Inappropriate shocks were mainly due to T-wave oversensing, but there were no lead complications requiring reintervention. Copyright © 2016. Published by Elsevier Inc.

  5. Isolation and attempted cultivation of an Anaplasma marginale strain from Brazilian brown brocket deer (Mazama gouazoubira, Fisher, 1814) in the tick cell line IDE8.

    Science.gov (United States)

    Silveira, Julia A G; Silvestre, Bruna T; Bastos, Camila V; Ribeiro, Múcio F B

    2016-10-01

    The aim of the study was to isolate and establish an Anaplasma marginale strain from Brazilian brown brocket deer, Mazama gouazoubira, in the Ixodes scapularis cell line IDE8. Blood from a free-living adult female M. gouazoubira naturally infected with A. marginale (MGI5) was inoculated intravenously into a splenectomized calf. When A. marginale rickettsemia was 2.5%, blood was collected and cryopreserved in liquid nitrogen with dimethylsulfoxide (DMSO). IDE8 cell cultures were infected with calf blood inoculated with the A. marginale (MG15) isolate. The cultures were monitored by examination of Giemsa-stained cytocentrifuge smears. Light microscopy of stained IDE8 samples revealed the first inclusions of A. marginale (MGI5) at 48days post-inoculation (d.p.i). The IDE8-infected cells contained parasitophorous vacuoles with amorphous material and a few cocci-like organisms. A sample from IDE8-infected cells from the 16th subculture (336 d.p.i.) was analyzed by nPCR, nucleotide sequencing, electron microscopy, and an indirect fluorescent antibody test (IFAT). The IFAT highlighted some IDE8-infected cells with intense fluorescence in the parasitophorous vacuole, while in other cells, fluorescence was observed only at the periphery. DNA from a culture of the MG15 isolate was amplified with A. marginale msp4 gene primers, and nucleotide sequencing of the PCR product and BLAST software analysis further confirmed 100% identity with the MGI5 blood isolate (GenBank no. JN022558.1). Electron microscopy revealed increased numbers of lysosomes in the cytoplasm of IDE8 cells. Several cells exhibited large vacuoles containing cellular debris and amorphous material. After the 29th subculture, it was not possible to detect compatible Anaplasma structures by light microscopy, and subculture samples tested negative in nPCR. Despite the failure of the attempt to establish A. marginale (MGI5) in IDE8 cells, the results demonstrated the isolate's ability to infect, survive and multiply

  6. Fenólicos e carotenóides totais em pitanga Total phenolics and carotenoids in surinam cherry

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Arroxelas Galvão de Lima

    2002-09-01

    Full Text Available Em decorrência de uma ampla diversidade genética, a pitanga (Eugenia uniflora L. apresenta cor que varia do alaranjado até o vermelho escuro quase negro. Em Pernambuco, no entanto, é comum encontrá-la com coloração laranja-avermelhada. Como muitos fitoquímicos presentes em frutos exibem propriedades antioxidantes, com destaque para carotenóides e compostos fenólicos, e frente a escassez de informações sobre seus teores em pitanga, objetivou-se quantificá-los nas seleções cujos frutos apresentam coloração vermelha e roxa. Assim, foram determinados espectrofotometricamente os teores de carotenóides e fenólicos totais nos frutos destas seleções nos estádios maduro e semi-maduro. Na pitanga roxa madura e em sua película também foram determinados os teores de antocianinas, flavonóis e carotenóides totais. Os compostos fenólicos e os carotenóides totais na pitanga roxa madura encontram-se em maiores teores do que na pitanga vermelha no mesmo estádio de maturação. A seleção roxa exibiu quantidade significante de antocianinas, cujo teor foi mais elevado no fruto maduro do que no semi-maduro. Os carotenóides, antocianinas e flavonóis encontram-se mais concentrados na película do que na polpa deste fruto maduro. A presença de antocianinas, flavonóis e carotenóides totais na pitanga roxa fazem deste fruto uma fonte promissora de compostos antioxidantes cujo cultivo deveria ser estimulado.Because of the genetic diversity, fruits of Surinam cherry (Eugenia uniflora L. show colours that range from orange to deep, almost dark red. However, in Pernambuco, Brazil, it is common to find this fruit with an orange-red colour. Many phytochemicals in fruits have antioxidant properties with emphasis on phenolic compounds and carotenoids. Since the information on these phytochemicals in surinam cherry is scarce, the aim of this research was to analyse them in fruits which show red and purple colours. Half-mature and mature fruits

  7. HAMBATAN SEMANTIK DAN BUDAYA DALAM PROSES TRANSFER IDE OLEH MAHASISWA JURUSAN NON BAHASA INGGRIS DALAM PENULISAN PARAGRAF

    Directory of Open Access Journals (Sweden)

    Doddy Rusmono

    2016-05-01

    Full Text Available Abstrak. Proses transfer ide dalam bentuk tulisan yang dilakukan oleh mahasiswa jurusan ilmu perpustakaan dan informasi sebagai mahasiswa jurusan non Bahasa Inggris (SNED yang mempelajari Bahasa Inggris sebagai bahasa asing (EFL perlu diinvestigasi. Ketidakmampuan untuk menjembatani kesenjangan antara ide dalam bahasa ibu (Bahasa Inggris dengan ide dalam bahasa pembaca (Bahasa Inggris menghambat pemahaman pembaca, khususnya pembaca yang merupakan penutur asli Bahasa Inggris. Paragraf yang ditulis oleh mahasiswa SNED sebagai pembelajar Bahasa Inggris tidak dapat dipahami karena hambatan linguistik dan budaya. Sejumlah kecil mahasiswa yang membuat tulisan Bahasa Inggris dalam ujian tengah semester memperlihatkan gambaran ketidaktepatan dalam hal menyusun kalimat sehingga Bahasa Inggris mereka pada tingkatan tertentu terdengar seperti Bahasa Indonesia. Dalam hal ini kemampuan mereka untuk menggunakan Bahasa Inggris seperti layaknya bahasa Indonesia terbukti sangat rendah sehingga seorang penutur asli Bahasa Inggris yang mencoba untuk memahami ide mereka bisa salah memahaminya. Seorang pembelajar Bahasa Inggris harus memiliki kosakata yang cukup banyak dan setidaknya mengetahui aturan gramatikal seperti formulasi 9BP+3CC (Cd,Cx,Cdx dan PoS misalnya, untuk melengkapi pemahaman sebelum benar-benar dapat mengekspresikan ide dalam tulisan Bahasa Inggris yang dapat dipahami. Selain itu, pengetahuan mahasiswa tentang budaya penutur Bahasa Inggris memainkan peranan yang sangat penting untuk menghasilkan tulisan yang bagus, sebagaimana yang diungkapkan oleh seorang ahli bahasa bahwa seringkali seorang pembelajar bahasa mengetahui aturan tata bahasa tetapi tidak memiliki pengetahuan yang cukup tentang budaya penutur asli. Mahasiswa mengalami kesulitan dalam mengkomunikasikan idenya dikarenakan ekspresi suatu ide terikat oleh budaya yang merupakan entitas independen. Budaya penutur asli mempengaruhi dan membentuk perasaan, sikap, dan respons terhadap

  8. Virulência de nematóides entomopatogênicos (Nematoda: Rhabditida a Sphenophorus levis (Coleoptera: Curculionidae

    Directory of Open Access Journals (Sweden)

    Fernando Henrique Carvalho Giometti

    2011-01-01

    Full Text Available O bicudo da cana-de-açúcar, Sphenophorus levis (Coleoptera: Curculionidae, é uma importante praga de solo dos canaviais no Estado de São Paulo, ocasionando prejuízos de até 30 t de cana/ha/ano. Visando ao controle biológico desta praga, esse estudo teve por objetivo avaliar a virulência de 17 isolados de nematóides entomopatogênicos do gênero Steinernema e Heterorhabditis contra adultos de S. levis, e o efeito dos quatro nematóides mais virulentos em três dosagens cada um. A pesquisa foi realizada em condições de laboratório, sendo realizados quatro ensaios para o estudo de virulência. Os nematóides selecionados como mais virulentos em cada teste foram S. brazilense IBCB n6, Heterorhabditis sp. IBCB n10, Heterorhabditis sp. IBCB n24 e Heterorhabditis sp. IBCB n44, sendo os únicos que diferenciaram significativamente das respectivas testemunhas com 45%, 40%, 20% e 31% de mortalidade do inseto na concentração de 240 juvenis infectivos (JI/inseto. No teste de dose, os isolados de Heterorhabditis identificados como IBCB n10, IBCB n24 e IBCB n44 destacaram-se quanto à virulência para os adultos do bicudo da cana-de-açúcar, diferindo significativamente da testemunha na maior dose avaliada (1200 JI/inseto com níveis de mortalidade do inseto de 60%, 65,7% e 74,3% respectivamente.

  9. Expressão antigênica em carcinomas do plexo coróide humano: relato de dois casos

    Directory of Open Access Journals (Sweden)

    M. C. Almeida

    1990-09-01

    Full Text Available Neoplasias provenientes do epitélio de revestimento do plexo coróide são inco-muns, tendo sido descritos 6 padrões morfológicos. O padrão anaplásico, também denominado carcinoma do plexo coróide, é o de menor freqüência e pode dar metastases fora do SNC. A distinção histológica desses tumores, particularmente da variedade anaplásica, com outras neoplasias primárias e metastáticas no SNC pode ser difícil. O uso de técnicas imunocitoquimicas em parafina tem-se mostrado útil no esclarecimento das linhagens tumorais. Os papilomas do plexo coróide têm, no entanto, sido objeto de controvérsia, por sua complexa expressão antigênica. Usando a técnica de imunoperoxidase (sistema avidina-biotina-peroxidase pesquisaram-se, em dois casos da variedade anaplásica, os seguintes marcadores: proteína glial fibrilar ácida (GFAP com anticorpo monoclonal e policlonal; ceratinas de 40-50kDa, ceratinas de 60-70kDa (callus ceratina, enolase neuronal específica (NSE e proteína S-100, com anticorpos monoclonais. Os dois tumores mostraram positividade para NSE, proteína S-100 e ceratina de 40-50kDa; uma das duas neoplasias mostrou diferenciação glial, revelando positividade para GFAP tanto com anticorpo monoclonal quanto policlonal.

  10. 19 CFR 148.55 - Exemption for articles bearing American trademark.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Exemption for articles bearing American trademark... § 148.55 Exemption for articles bearing American trademark. (a) Application of exemption. An exemption... 42 of the Act of July 5, 1946 (60 Stat. 440; 15 U.S.C. 1124), because the trademark has been...

  11. 40 CFR 180.1092 - Menthol; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Menthol; exemption from the... Exemptions From Tolerances § 180.1092 Menthol; exemption from the requirement of a tolerance. An exemption from the requirement of a tolerance is established for residues of the pesticidal chemical menthol in...

  12. 40 CFR 180.1177 - Potassium bicarbonate; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Potassium bicarbonate; exemption from... FOOD Exemptions From Tolerances § 180.1177 Potassium bicarbonate; exemption from the requirement of a tolerance. The biochemical pesticide potassium bicarbonate is exempted from the requirement of a tolerance...

  13. 40 CFR 180.1176 - Sodium bicarbonate; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Sodium bicarbonate; exemption from the... Exemptions From Tolerances § 180.1176 Sodium bicarbonate; exemption from the requirement of a tolerance. The biochemical pesticide sodium bicarbonate is exempted from the requirement of a tolerance in or on all raw...

  14. 29 CFR 2570.49 - Limits on the effect of exemptions.

    Science.gov (United States)

    2010-07-01

    ... Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF... Prohibited Transaction Exemption Applications § 2570.49 Limits on the effect of exemptions. (a) An exemption does not take effect or protect parties in interest from liability with respect to the exemption...

  15. 40 CFR 180.1040 - Ethylene glycol; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Ethylene glycol; exemption from the... Exemptions From Tolerances § 180.1040 Ethylene glycol; exemption from the requirement of a tolerance. Ethylene glycol as a component of pesticide formulations is exempt from the requirement of a tolerance when...

  16. 40 CFR 180.1224 - Bacillus pumilus GB34; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus pumilus GB34; exemption from... FOOD Exemptions From Tolerances § 180.1224 Bacillus pumilus GB34; exemption from the requirement of a... pesticide Bacillus pumilus GB34 when used as a seed treatment in or on all food commodities. An exemption is...

  17. 40 CFR 180.1269 - Bacillus mycoides Isolate J: exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus mycoides Isolate J: exemption... FOOD Exemptions From Tolerances § 180.1269 Bacillus mycoides Isolate J: exemption from the requirement of a tolerance. Bacillus mycoides isolate J is temporarily exempt from the requirement of a tolerance...

  18. 40 CFR 180.1157 - Cytokinins; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Cytokinins; exemption from the... Exemptions From Tolerances § 180.1157 Cytokinins; exemption from the requirement of a tolerance. An exemption from the requirement of a tolerance is established for residues of cytokinins (specifically: aqueous...

  19. 40 CFR 180.1187 - L-glutamic acid; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false L-glutamic acid; exemption from the... Exemptions From Tolerances § 180.1187 L-glutamic acid; exemption from the requirement of a tolerance. L-glutamic acid is exempt from the requirement of a tolerance on all food commodities when used in accordance...

  20. 40 CFR 180.1095 - Chlorine gas; exemptions from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Chlorine gas; exemptions from the... Exemptions From Tolerances § 180.1095 Chlorine gas; exemptions from the requirement of a tolerance. Chlorine gas is exempted from the requirement of a tolerance when used preharvest or postharvest in solution on...

  1. 40 CFR 180.1160 - Jojoba oil; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Jojoba oil; exemption from the... Exemptions From Tolerances § 180.1160 Jojoba oil; exemption from the requirement of a tolerance. The insecticide and spray tank adjuvant jojoba oil is exempted from the requirement of a tolerance in or on all...

  2. 77 FR 65937 - Pioneer Railcorp-Continuation in Control Exemption-Rail Switching Services, Inc.

    Science.gov (United States)

    2012-10-31

    ... TRANSPORTATION Surface Transportation Board Pioneer Railcorp--Continuation in Control Exemption--Rail Switching... exemption pursuant to 49 CFR 1180.2(d)(2) to continue in control of Rail Switching Services, Inc. (RSS... of exemption in Rail Switching Services, Inc.--Operation Exemption-- Pemiscot County Port Authority...

  3. 40 CFR 180.1111 - Bacillus subtilis GB03; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus subtilis GB03; exemption from... FOOD Exemptions From Tolerances § 180.1111 Bacillus subtilis GB03; exemption from the requirement of a tolerance. The biofungicide Bacillus subtilis GB03 is exempted from the requirement of a tolerance in or on...

  4. 29 CFR 2570.32 - Persons who may apply for exemptions.

    Science.gov (United States)

    2010-07-01

    ... Prohibited Transaction Exemption Applications § 2570.32 Persons who may apply for exemptions. (a) The Department may initiate exemption proceedings on its own motion. In addition, the Department will initiate exemption proceedings upon the application of: (1) Any party in interest to a plan who is or may be a party...

  5. 40 CFR 180.1188 - Gamma aminobutyric acid; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Gamma aminobutyric acid; exemption... FOOD Exemptions From Tolerances § 180.1188 Gamma aminobutyric acid; exemption from the requirement of a tolerance. Gamma aminobutyric acid is exempt from the requirement of a tolerance on all food commodities...

  6. A importância da tiróide nas perturbações da mente

    OpenAIRE

    Abreu, Glória Patrícia Pedrosa de

    2011-01-01

    Introdução: A tiróide é uma glândula que intervém em vários mecanismos fisiopatológicos. O défice ou o excesso das hormonas tiroideias foi relacionado com o aparecimento de várias perturbações psiquiátricas. Os indivíduos com hipertiroidismo são mais susceptíveis a desenvolver depressão, mania, psicose, ansiedade, demência, comportamento violento e, eventualmente, ideação suicida. Por outro lado, os que apresentam hipotiroidismo manifestam, frequentemente, depressão, apatia, ma...

  7. Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B.

    Science.gov (United States)

    Lai, Ching-Lung; Wong, Danny; Ip, Philip; Kopaniszen, Malgorzata; Seto, Wai-Kay; Fung, James; Huang, Fung-Yu; Lee, Brian; Cullaro, Giuseppe; Chong, Chun Kong; Wu, Ringo; Cheng, Charles; Yuen, John; Ngai, Vincent; Yuen, Man-Fung

    2017-02-01

    Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), a mini-chromosome essential for HBV replication, is supposed to be resistant to nucleos(t)ide analogue treatment. We investigated the effect of long-term nucleos(t)ide analogue treatment on cccDNA. Among 129 patients who had been enrolled in previous international nucleos(t)ide analogue clinical trials and had liver biopsies at baseline and one year after treatment, we recruited 43 patients on long-term continuous treatment for 72 to 145months for a third liver biopsy. Serum HBV DNA, hepatitis B surface antigen (HBsAg) levels, total intrahepatic HBV DNA (ihHBV DNA), cccDNA, HBV pregenomic RNA (pgRNA) as well as histologic changes were examined. At the time of the third biopsy, serum HBV DNA levels were undetectable in all but one patient. The median levels of HBsAg, ihHBV DNA, and cccDNA were 2.88logIU/ml, 0.03copies/cell, and 0.01copies/cell, respectively. Compared to baseline levels, there was reduction of HBsAg levels by 0.54log (71.46%), ihHBV DNA levels by 2.81log (99.84%), and cccDNA levels by 2.94log (99.89%), with 49% having cccDNA levels below the detection limit. One patient had undetectable HBsAg. The median pgRNA level, measured only in the third biopsy, was 0.021copies/cell, with 40% of patients having undetectable pgRNA. Long-term nucleos(t)ide analogue treatment induced marked depletion of cccDNA in the majority of patients while serum HBsAg levels, though reduced, were detectable in all but one patient. Whether cccDNA depletion is sustained and associated with better patient outcome requires further study. It is generally presumed that a form of hepatitis B virus DNA, called covalently closed circular DNA (cccDNA), which hides inside the nuclei of liver cells of patients with chronic hepatitis B, cannot be reduced by antiviral treatment. The present study showed that with prolonged treatment (median period 126months), cccDNA can be markedly reduced, with 49% of liver biopsies having

  8. Terpenóides e seu metabolismo em fungos: um estudo de Scleroderma sp. e Xylaria sp.

    OpenAIRE

    Diego Zulkiewicz Gomes

    2011-01-01

    No presente trabalho foram isolados os triterpenos lanostanos Lanosta-8,24-diene-3ß,23-diol e Lanosta-8,23-diene-3ß,25-diol do basidiomiceto Scleroderma sp., uma fonte rica em triterpenos e ainda não reportada como produtora destes metabólitos. As estruturas moleculares foram completamente determinadas por RMN 1D e 2D e análises de espectrometria de massas, tendo ainda as fragmentações propostas. Esses e outros substratos foram considerados para o estudo do metabolismo de terpenóides em Xylar...

  9. Nocardiose pulmonar em paciente usuário crônico de corticóides

    OpenAIRE

    Renata Maria Ferreira Brasileiro; André Carvalho Caribe de Araújo Pinho; Catarine Silva Medeiros; Francisco Ferri; Leonardo de Lucca Schiavon; Janaína Luz Narciso-Schiavon; Fernando Costa Buzzoleti

    2007-01-01

    Nocardiose pulmonar é uma infecção grave e incomum causada pela Nocardia ssp, microorganismos que podem se comportar tanto como oportunistas quanto patógenos primários e que pode se apresentar como desordem aguda ou crônica supurativa. Relata-se o caso de um paciente de 49 anos, portador de púrpura trombocitopênica idiopática em tratamento com corticóides que desenvolveu infecção pulmonar por Nocardia farcinica, isolada em hemocultura. Apesar de tratamento correto com sulfametoxazol-trimetopr...

  10. 77 FR 33554 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-06-06

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER INFORMATION CONTACT...

  11. 77 FR 27842 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-05-11

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM) operating...://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief...

  12. 29 CFR 541.203 - Administrative exemption examples.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Administrative exemption examples. 541.203 Section 541.203 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS... productivity improvements) generally meets the duties requirements for the administrative exemption, even if...

  13. 77 FR 52381 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-08-29

    ... prosthetic left eye due to a traumatic injury sustained in 2006. The best corrected visual acuity in his... meet the vision requirement in one eye for various reasons. The exemptions will enable these... vision requirement in one eye. If granted, the exemptions would enable these individuals to qualify as...

  14. 78 FR 19537 - SHINE Medical Technologies, Inc.; Exemption

    Science.gov (United States)

    2013-04-01

    ... under 10 CFR 2.101(a)(5), as proposed, an exemption to the regulations is required. Given the dependency... requested is not for an exemption to a 10 CFR part 50 regulation, given the dependency of docketing a... quality of the human environment as it is procedural in nature. Furthermore, the Commission has determined...

  15. 78 FR 12809 - Qualification of Drivers; Application for Exemptions; Hearing

    Science.gov (United States)

    2013-02-25

    ...-research/research-technology/publications/medreport_archives.htm . FMCSA Requests Comments on the Exemption... exemptions; request for comments. SUMMARY: FMCSA announces that 9 individuals have applied for a medical... . FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief Medical Programs, (202) 366-4001, fmcsamedical...

  16. 76 FR 49788 - Exemptions From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2011-08-11

    ... Brotherhood of Carpenters Pension Fund (the Plan), 2011-11; and L-11651 and L-11652, Verizon Communications... Department at (202) 693-8648. (This is not a toll-free number.) The United Brotherhood of Carpenters Pension Fund (the Plan), Located in Las Vegas, Nevada, [Prohibited Transaction Exemption 2011- 11; Exemption...

  17. 9 CFR 106.1 - Biological products; exemption.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS EXEMPTION FOR BIOLOGICAL PRODUCTS USED IN DEPARTMENT PROGRAMS OR UNDER DEPARTMENT CONTROL OR SUPERVISION § 106.1 Biological products... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Biological products; exemption. 106.1...

  18. 40 CFR 204.5-2 - National security exemptions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false National security exemptions. 204.5-2... PROGRAMS NOISE EMISSION STANDARDS FOR CONSTRUCTION EQUIPMENT General Provisions § 204.5-2 National security... for a national security exemption is required. (c) For purposes of section 11(d) of the Act, any...

  19. 40 CFR 211.110-2 - National security exemptions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false National security exemptions. 211.110... ABATEMENT PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.110-2 National security exemptions. (a) A new product which is produced to conform with specifications developed by national security agency...

  20. 40 CFR 205.5-2 - National security exemptions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false National security exemptions. 205.5-2... PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.5-2 National security... a national security exemption is required. (c) For purposes of section 11(d) of the Act, any...

  1. 40 CFR 85.1708 - National security exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false National security exemption. 85.1708... Vehicle Engines § 85.1708 National security exemption. A manufacturer requesting a national security... agency of the Federal Government charged with responsibility for national defense. ...

  2. 10 CFR 871.1 - National security exemption.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false National security exemption. 871.1 Section 871.1 Energy DEPARTMENT OF ENERGY AIR TRANSPORTATION OF PLUTONIUM § 871.1 National security exemption. (a) The following DOE air shipments of plutonium are considered as being made for the purposes of national security...

  3. 29 CFR 1612.4 - Exemptions to open meeting policy.

    Science.gov (United States)

    2010-07-01

    ... security intelligence investigation, confidential information furnished only by the confidential source, (5... 29 Labor 4 2010-07-01 2010-07-01 false Exemptions to open meeting policy. 1612.4 Section 1612.4... THE SUNSHINE ACT REGULATIONS § 1612.4 Exemptions to open meeting policy. Except in a case where the...

  4. 75 FR 70078 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-11-16

    ..., complete loss of vision, loss of an eye, macular scarring and prosthesis. In most cases, their eye... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision.... SUMMARY: FMCSA announces its decision to exempt 15 individuals from the vision requirement in the Federal...

  5. 77 FR 76770 - Proposed Exemptions From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2012-12-28

    ... modify Section III.X of the individual Prohibited Transaction Exemptions (PTEs) and final authorizations... real property or leasehold interests therein. Section II of the original Underwriter Exemptions (PTEs... Department amended PTEs 89-88, 89-89, and 89-90 at 55 FR 48939 to include Fitch Inc. as an acceptable credit...

  6. 78 FR 41090 - Exemption From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2013-07-09

    ... Transaction Exemptions (PTEs), as set forth below: PTE 89-88, 54 FR 42582 (October 17, 1989); PTE 89-89, 54 FR... Applicants) (PTEs 94-29 and 94-73, respectively); A. Section III.A. of this exemption is modified to read as...

  7. 36 CFR 1120.42 - Release of exempt documents.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Release of exempt documents. 1120.42 Section 1120.42 Parks, Forests, and Public Property ARCHITECTURAL AND TRANSPORTATION BARRIERS... exempt documents. (a) An A&TBCB office may, in its discretion, release requested records despite the...

  8. 40 CFR 72.8 - Retired units exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Retired units exemption. 72.8 Section...) PERMITS REGULATION Acid Rain Program General Provisions § 72.8 Retired units exemption. (a) This section applies to any affected unit (except for an opt-in source) that is permanently retired. (b)(1) Any...

  9. 49 CFR 385.815 - Exemption for AOBRD users.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Exemption for AOBRD users. 385.815 Section 385.815 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY... Remedial Directives § 385.815 Exemption for AOBRD users. (a) Upon written request by the motor carrier...

  10. 40 CFR 166.49 - Public notice of crisis exemptions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Public notice of crisis exemptions. 166.49 Section 166.49 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS EXEMPTION OF FEDERAL AND STATE AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Crisis...

  11. 78 FR 65754 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-11-01

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... persons with insulin-treated diabetes mellitus (ITDM) from operating commercial motor vehicles (CMVs) in... August 19, 2013, FMCSA published a notice of receipt of Federal diabetes exemption applications from 23...

  12. 48 CFR 252.229-7002 - Customs exemptions (Germany).

    Science.gov (United States)

    2010-10-01

    ... (Germany). 252.229-7002 Section 252.229-7002 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.229-7002 Customs exemptions (Germany). As prescribed in 229.402-70(b), use the following clause: Customs Exemptions (Germany) (JUN 1997) Imported products required for the...

  13. 7 CFR 1216.56 - Exemption for organic peanuts.

    Science.gov (United States)

    2010-01-01

    ... producer's name and address, a copy of the organic farm or organic handling operation certificate provided... 7 Agriculture 10 2010-01-01 2010-01-01 false Exemption for organic peanuts. 1216.56 Section 1216... Assessments § 1216.56 Exemption for organic peanuts. (a) A producer who operates under an approved National...

  14. 7 CFR 1219.202 - Exemption for organic Hass avocados.

    Science.gov (United States)

    2010-01-01

    ... organic farm or organic handling operation certificate provided by a USDA-accredited certifying agent as... 7 Agriculture 10 2010-01-01 2010-01-01 false Exemption for organic Hass avocados. 1219.202 Section... AVOCADO PROMOTION, RESEARCH, AND INFORMATION Rules and Regulations § 1219.202 Exemption for organic Hass...

  15. 7 CFR 1206.202 - Exemption for organic mangos.

    Science.gov (United States)

    2010-01-01

    ... certificate provided by a USDA-accredited certifying agent as defined in the Organic Act, a signed... 7 Agriculture 10 2010-01-01 2010-01-01 false Exemption for organic mangos. 1206.202 Section 1206... PROMOTION, RESEARCH, AND INFORMATION Rules and Regulations § 1206.202 Exemption for organic mangos. (a) A...

  16. 41 CFR 109-39.106 - Unlimited exemptions.

    Science.gov (United States)

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.106 Unlimited exemptions. The Director, Office of... determination that an unlimited exemption from inclusion of a motor vehicle in a fleet management system is...

  17. 46 CFR 535.312 - Vessel charter party-exemption.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Vessel charter party-exemption. 535.312 Section 535.312... Vessel charter party-exemption. (a) For purposes of this section, vessel charter party shall mean a... operational limitations, if any) under which the vessel will be employed. (b) Vessel charter parties, as...

  18. 29 CFR 793.20 - Exclusive engagement in exempt work.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Exclusive engagement in exempt work. 793.20 Section 793.20 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS EXEMPTION OF CERTAIN RADIO AND TELEVISION STATION EMPLOYEES FROM OVERTIME...

  19. 9 CFR 381.500 - Exemption from nutrition labeling.

    Science.gov (United States)

    2010-01-01

    ... purported to be specifically for infants and children less than 4 years of age shall bear nutrition labeling... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Exemption from nutrition labeling. 381... INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Nutrition Labeling § 381.500 Exemption...

  20. 9 CFR 317.400 - Exemption from nutrition labeling.

    Science.gov (United States)

    2010-01-01

    ... purported to be specifically for infants and children less than 4 years of age shall bear nutrition labeling... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Exemption from nutrition labeling. 317... INSPECTION AND CERTIFICATION LABELING, MARKING DEVICES, AND CONTAINERS Nutrition Labeling § 317.400 Exemption...

  1. 19 CFR 148.46 - Sale of exempted articles.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Sale of exempted articles. 148.46 Section 148.46... exempted articles. (a) Sale resulting in forfeiture. The following articles or their value (to be recovered... paragraph (b) of this section is followed: (1) Any jewelry or similar articles of personal adornment having...

  2. 19 CFR 12.104h - Exempt materials and articles.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Exempt materials and articles. 12.104h Section 12... THE TREASURY SPECIAL CLASSES OF MERCHANDISE Cultural Property § 12.104h Exempt materials and articles... material or any article of cultural property which is imported into the U.S. for temporary exhibition or...

  3. 27 CFR 24.76 - Tax exempt cider.

    Science.gov (United States)

    2010-04-01

    ... OF THE TREASURY LIQUORS WINE Administrative and Miscellaneous Provisions Tax Exempt Wine § 24.76 Tax exempt cider. Cider, when produced solely from the noneffervescent fermentation of apple juice without the use of any preservative method or material, and when produced at a place other than a bonded wine...

  4. Aplicação de formulação do fungo predador de nematóides Monacrosporium thaumasium (Drechsler, 1937 no controle de nematóides de bovinos

    Directory of Open Access Journals (Sweden)

    Alves P.H.

    2003-01-01

    Full Text Available A viabilidade de uma formulação do fungo Monacrosporium thaumasium (Drechsler, 1937 foi avaliada no controle biológico de nematóides parasitos gastrintestinais de bovinos. Dois grupos de sete bezerras cada, mestiças Holandês ´ Zebu, de quatro a seis meses de idade, foram colocados em pastagens de Cynodon dactilon. No grupo A, cada animal recebeu 20g de pellets (formulação granulada de M. thaumasium via oral, duas vezes por semana, durante quatro meses, com início na estação chuvosa (outubro, 2001. No grupo B (controle, as bezerras não receberam nenhum tratamento. As contagens de ovos por grama de fezes (OPG e das larvas infectantes encontradas na pastagem do grupo B foram significativamente maiores (P<0,05 do que as do grupo A e a diferença entre o OPG dos animais dos grupos A e B, no final do experimento, foi de 88,8%. O gênero Cooperia foi o mais prevalente em ambas as pastagens. Conclui-se que a aplicação de pellets de M. thaumasium na dosagem e periodicidade de aplicação usadas foi eficiente no controle de nematóides parasitos gastrintestinais de bovinos.

  5. Impacto de inseticidas sobre parasitóides da traça-das-crucíferas em repolho, no Distrito Federal

    Directory of Open Access Journals (Sweden)

    Castelo Branco Marina

    2001-01-01

    Full Text Available Este trabalho teve como objetivo identificar os parasitóides da Plutella xylostella(L. presentes em áreas de cultivo do Distrito Federal, tratadas ou não com inseticidas, onde larvas do inseto foram coletadas. Foram identificados quatro parasitóides: Apantelessp. (Braconidae, Oomyzus sokolowiskii (Kurdjumov (Eulophidae, Diadegmasp. (Ichneumonidae e Actiasp. (Tachinidae. Onível de parasitismo nas áreas não tratadas com inseticidas variou de 5% a 94%, enquanto em áreas tratadas variou de 11% a 87%. A maior parte das larvas de traça-das-crucíferas foram encontradas nas cabeças de repolho ou na parte inferior das folhas da saia das plantas. Esta distribuição de larvas sobre as plantas deve permitir que estas escapem do contato com o inseticida, e, conseqüentemente, os parasitóides podem sobreviver nas plantas tratadas.

  6. Comparação de dois tipos de colóides tecneciados na detecção de gânglio sentinela

    OpenAIRE

    L. Dias; Geão, A; Mota, A.; Santos, A.; Quaresma, P.; Colarinha, P

    2011-01-01

    Introdução: O gânglio sentinela define-se como o primeiro gânglio detectado numa via de drenagem linfática do tumor primário. O marcador ideal para pesquisa de gânglio sentinela deve apresentar: retenção persistente neste gânglio, reduzida acumulação de radiofármaco nos gânglios satélites e depuração rápida do local de injecção. Há dois tipos de colóides tecneciados que são frequentemente utilizados em linfocintigrafia – colóides de albumina humana e colóides de sulfureto d...

  7. O papel dos antagonistas periféricos dos opióides no tratamento da dor e nos cuidados perioperatórios

    OpenAIRE

    Tanaka,Pedro Paulo; Moss,Jonathan

    2008-01-01

    JUSTIFICATIVA E OBJETIVOS: Estudos clínicos e pré-clínicos sobre os antagonistas periféricos dos opióides aumentaram nosso conhecimento sobre os efeitos dos opióides exógenos e endógenos. CONTEÚDO: Este artigo faz uma revisão dos estudos clínicos e pré-clínicos sobre a disfunção intestinal secundária ao uso de opióides. CONCLUSÕES: Se forem aprovados, esses fármacos podem representar soluções importantes para os problemas encontrados na prática médica com relação ao tratamento da dor....

  8. O papel dos antagonistas periféricos dos opióides no tratamento da dor e nos cuidados perioperatórios

    OpenAIRE

    Tanaka, Pedro Paulo; Moss, Jonathan

    2008-01-01

    JUSTIFICATIVA E OBJETIVOS: Estudos clínicos e pré-clínicos sobre os antagonistas periféricos dos opióides aumentaram nosso conhecimento sobre os efeitos dos opióides exógenos e endógenos. CONTEÚDO: Este artigo faz uma revisão dos estudos clínicos e pré-clínicos sobre a disfunção intestinal secundária ao uso de opióides. CONCLUSÕES: Se forem aprovados, esses fármacos podem representar soluções importantes para os problemas encontrados na prática médica com relação ao tratamento da dor. BACK...

  9. Uveíte anterior na ausência de esclerite em paciente com artrite reumatóide: relato de caso

    OpenAIRE

    Daguano,Carolina Rottili; Bochnia,Claudia Regina; Gehlen,Marcelo

    2011-01-01

    A artrite reumatóide é a colagenose mais comum, afetando cerca de 0,6% da população brasileira e é uma grande causadora de deformidades articulares em mais variadas formas. A principal manifestação ocular da artrite reumatóide é a ceratoconjuntivite sicca (Sjögren secundária), seguida pela esclerite, úlcera periférica da córnea e uveíte. O objetivo deste trabalho é apresentar um caso de uveíte anterior em paciente com artrite reumatóide, uma apresentação rara em pacientes com esta patologia. ...

  10. Doenças auto-imunes da tiróide: associação com gastrite auto-imune

    OpenAIRE

    Marinho, Ana Sofia santos

    2013-01-01

    As patologias auto-imunes da tiróide, incluindo tiroidite linfocítica crónica e doença de Graves, são doenças auto-imunes específicas de órgão, caracterizadas por infiltração linfocítica da tiróide. Auto-anticorpos contra antigénios da tiróide (anticorpos anti-peroxidase tiroideia, anti-tiroglobulina e anti-receptor da tirotropina), são frequentemente encontrados no soro dos doentes. A gastrite atrófica é uma alteração que afecta a mucosa corporal e quando associada com anemia perniciosa é...

  11. Sexagem de espermatozóides bovinos por centrifugação em gradiente de densidade contínuo de Percoll e OptiPrep

    OpenAIRE

    RESENDE, Max Vitória

    2007-01-01

    Os objetivos deste trabalho foram de facilitar os procedimentos de formação de gradientes de- densidade de Percoll e OptiPrep para separação de espermatozóides X; avaliar a eficiência da sexagem de espermatozóides X, a viabilidade espermática e integridade do acrossoma e do DNA após a centrifugação nestes gradientes e avaliar taxa de clivagem e blastocisto durante a produção in vitro de embriões. Para isso, doses de sêmen de touros foram descongeladas e cerca de 40 milhões de espermatozóides ...

  12. Contribuição à anatomia arterial do cólon sigmóide aplicável a operações de abaixamento

    OpenAIRE

    Siqueira,Sávio Lana; Lázaro-da-Silva,Alcino

    2003-01-01

    RACIONAL: A vascularização do sigmóide apresenta variações que podem ser importantes no uso daquele segmento nas operações de intestino grosso. OBJETIVOS: Realizou-se investigação anatômica da vascularização arterial do colón sigmóide para se obter um parâmetro que possa ser aplicado a raciocínio tático nas operações de abaixamento do cólon sigmóide ao períneo, após a ressecção alargada do reto-ânus e seus esfíncteres na neoplasia maligna retoanal. MATERIAL E MÉTODOS: Analisou-se o mesocólon ...

  13. Esteróides anabolizantes no esporte Anabolic steroids in sports

    Directory of Open Access Journals (Sweden)

    Paulo Rodrigo Pedroso da Silva

    2002-12-01

    Full Text Available Os hormônios esteróides anabólicos androgênicos (EAA compreendem a testosterona e seus derivados. Eles são produzidos nos testículos e no córtex adrenal, e promovem as características sexuais secundárias associadas à masculinidade. Na medicina, os EAA são utilizados geralmente no tratamento de sarcopenias, do hipogonadismo, do câncer de mama e da osteoporose. Nos esportes, são utilizados para o aumento da força física e da massa muscular; entretanto, os efeitos sobre o desempenho atlético permanecem, ainda, controversos. Os EAA podem causar diversos efeitos colaterais, como psicopatologias, câncer de próstata, doença coronariana e esterilidade. Estudos epidemiológicos apontam a problemática acerca do uso de EAA, nos esportes; todavia, no Brasil não existem publicações substanciais sobre esse tema. Esta revisão analisa esse assunto, procurando despertar a curiosidade e o interesse dos leitores para a produção científica de novos trabalhos relacionados ao tema.Anabolic androgenic steroids (AAS are hormones that include or are derivatives of testosterone. They are produced in the testicles and in the adrenal cortex. AAS promote development of sexual characteristics associated with the male sex. They are applied as a general rule in the treatment of sarcopenia, hypogonadism, breast cancer, and osteoporosis. In relation to sports, they are used to increase strength and muscle mass. Their effects on athletics performance are still controversial. AAS can cause several side-effects, such as mental disease, prostate cancer, coronary disease, and sterility. There are no epidemiologic studies regarding the use of AAS in Brazil . This review intends to deal with this matter widely and aims at stimulating curiosity and interest in order to provide new publications about this issue.

  14. Uveíte anterior na ausência de esclerite em paciente com artrite reumatóide: relato de caso

    Directory of Open Access Journals (Sweden)

    Carolina Rottili Daguano

    2011-04-01

    Full Text Available A artrite reumatóide é a colagenose mais comum, afetando cerca de 0,6% da população brasileira e é uma grande causadora de deformidades articulares em mais variadas formas. A principal manifestação ocular da artrite reumatóide é a ceratoconjuntivite sicca (Sjögren secundária, seguida pela esclerite, úlcera periférica da córnea e uveíte. O objetivo deste trabalho é apresentar um caso de uveíte anterior em paciente com artrite reumatóide, uma apresentação rara em pacientes com esta patologia. Paciente feminina, 55 anos, portadora de artrite reumatóide, apresentando quadro de dor e piora súbita da acuidade visual no olho direito. O exame mostrava reação de câmara anterior com hipópio, úlcera corneana periférica e pressão intraocular de 32 mmHg. Foi realizado o diagnóstico de uveíte anterior hipertensiva e úlcera corneana periférica e realizado tratamento com corticóide oral e tópico, antibiótico tópico, colírio cicloplégico e hipotensores oculares tópicos e sistêmicos. Os casos de uveíte anterior são comuns em doenças reumatológicas, principalmente em artropatias soronegativas relacionadas ao HLA-B27, conferindo grande causa de morbidade a esses pacientes. Neste trabalho relatamos um caso de uveíte anterior em paciente com artrite reumatóide, uma apresentação rara encontrada na literatura médica atual.

  15. Desenvolvimento de populações duplo-haplóides de cevada cervejeira associadas à atividade das enzimas (1-3, 1-4-β-glucanases

    Directory of Open Access Journals (Sweden)

    Janaína Endres Georg-Kraemer

    2011-05-01

    Full Text Available Populações duplo-haplóides apresentam especial vantagem para análises genéticas, uma vez que a informação que elas oferecem pode ser maximizada, devido ao fato que todos os locos encontram-se em homozigose. O objetivo deste trabalho foi o desenvolvimento de duas populações duplo-haplóides (DHs de cevada (Hordeum vulgare ssp. vulgare L. segregantes para a atividade das enzimas (1-3, 1-4-β-glucanases, através da técnica de cultura de anteras. Foram realizados dois cruzamentos com cultivares contrastantes para esta característica. As cultivares parentais selecionadas foram 'MN 698' e 'CEV 97047', para o desenvolvimento da população "malte verde" (MV, e 'Embrapa 127' e 'CEV 96025' para o desenvolvimento da população "malte seco" (MS. Foram cultivadas 10.734 anteras da população MS e 4.139 anteras da população MV. A população MV produziu 50% mais plântulas verdes quando comparada à população MS, refletindo a importância do genótipo na resposta à cultura de anteras e na regeneração. A maioria das plantas adultas duplo-haplóides foi obtida através da duplicação espontânea in vitro do genoma haplóide, ocorrendo em 66% das plantas da população MS e 76% das plantas da população MV. Também foram observadas, em menor frequência, plantas haplóides, triplóides e tetraplóides. Através da técnica de cultura de anteras, foram desenvolvidas 204 linhagens duplo-haplóides, das quais 72 linhagens são da população "malte seco" e 132 linhagens são da população "malte verde". Este material constitui um importante germoplasma para o melhoramento genético da cevada.

  16. Análise toxicológica dos canabinóides sintéticos enquanto novas drogas psicoativas

    OpenAIRE

    Ribeiro, Maria Isabel; Silva, Carina; Pires, Carla; Fonseca, Rui; Araújo, André

    2016-01-01

    Os canabinóides são substâncias encontradas na planta cannabis, cujos efeitos psicoativos devem-se sobretudo ao composto Δ9-tetra-hidrocanabinol (Δ9-THC). Desde a sua descoberta novos compostos análogos foram sintetizados para uso farmacológico e, mais recentemente como drogas de abuso. Os seus efeitos fisiológicos e psicoativos são semelhantes ao Δ9-THC, mas com maior intensidade e toxicidade. Esta investigação teve como objetivos, descrever a farmacocinética dos canabinóides sintéticos (CS)...

  17. Study of different 3-aminopropyl triethoxysilane (APTES) concentration on TiO2 particles based IDE for cervical cancer detection

    Science.gov (United States)

    Raqeema, S.; Hashim, U.; Azizah, N.; Nadzirah, Sh.; Arshad, M. K. Md; Ruslinda, A. R.; Gopinath, Subash C. B.

    2017-03-01

    HPV that also called Human Papillomaviruses is the major cause of the cervical cancer. HPV 16 and HPV 18 are the two types of HPV are the most HPV-associated cancers and responsible as a high-risk HPV. Cervical cancer taken about 70 percent of all cases due HPV infections. Cervical malignancy for the most part development on a lady's cervix and its was developed slowly as cancer disease. TiO2 particles give better performance and low cost of the biosensor. The used of 3-aminopropyl triethoxysilane (APTES) will be more efficient for DNA nanochip. APTES used as absorption reaction to immobilize organic biomolecules on the inorganic surface. Besides, APTES give better functionalization of the adsorption mechanism on IDE. The surface functionalized for immobilizing the DNA, which is the combination of the DNA probe and the HPV target produce high sensitivity andfast detection of the IDE. The Current-Voltage (IV) characteristic proved the sensitivity of the DNA nanochip increase as the concentration varied from 0% concentration to 24% of APTES concentration.

  18. A inércia estrutural da base produtiva brasileira: o IDE e a transferência internacional de tecnologia

    Directory of Open Access Journals (Sweden)

    TULIO CHIARINI

    2016-06-01

    Full Text Available RESUMO O que pode explicar o fato de ter havido uma entrada maciça de IDE no Brasil e ter-se mantido uma inercial estrutural na base produtiva nacional? Existe uma série de fatos macroeconômicos que podem ajudar a explicar essa inércia, como a baixa taxa de investimento e a falta de ordenação dos preços-chave da economia (como taxas de juros e taxa de câmbio, mas a proposição aqui feita é que existe um problema microeconômico estrutural relevante: falta de aptidão tecnológica das empresas industriais brasileiras. Para analisar tal proposição parte-se da separação entre os tipos de IDE (greenfield, fusão e aquisição e 'em carteira' e os tipos de canais de transferência de tecnologia (horizontal e vertical. A partir de elementos empíricos e históricos constrói-se o argumento de que a falta de aptidão tecnológica é elemento-chave no entendimento da perda de dinamismo da indústria nacional.

  19. Plexos coróides: estudo histopatológico em diferentes faixas etárias

    Directory of Open Access Journals (Sweden)

    Deise Regina Maffazzoni

    1986-12-01

    Full Text Available Os autores estudaram 146 casos de plexos coróides provenientes de autópsias realizadas no Departamento de Patologia da FFFCMPA, no período de janeiro de 1983 a outubro de 1984, com a finalidade de analisar as alterações histo-patológicas nas diferentes fases da vida. As idades dos pacientes estudados oscilaram de 26 semanas de vida intra-uterina a 87 anos. O estudo abrange 6 fetos, 26 recém-nascidos, 34 casos até um ano de idade, 4 de um a dois anos, 14 de 2 a 10 anos, 3 de 10 a 20 anos, 7 entre 20 a 30 anos, 14 de 30 a 40 anos, 23 de 40 a 60 anos, 12 de 60 a 80 anos e, três acima de 80 anos. A análise dos casos demonstrou diferenças quanto ao aspecto histopatológico dos plexos coróides, que variaram de células epiteliais vacuolizadas, presença de material eosinofílico no interstício - nos primeiros anos de vida - a calcificações restritas ao glomus e psamomas ou calcificações grosseiras, cuja intensidade acentuou-se com o aumento da faixa etária.

  20. Carcinoma bilateral do plexo coróide operado com sucesso Bilateral carcinoma of the choroid plexus operated successfully

    Directory of Open Access Journals (Sweden)

    Gilberto M. de Almeida

    1970-06-01

    Full Text Available Os autores não encontraram na literatura caso de carcinoma bilateral do plexo coróide operado com sucesso. O trabalho consta da apresentação de uma criança de 11 anos com carcinoma dos plexos coróides nos dois ventrículos laterais. São feitas considerações a respeito das dificuldades no diagnóstico, da importância dó estudo angiográfico completo e do tratamentoA case of bilateral carcinoma of the choroid plexus is reported. Bilateral carcinoma of the choroid plexus are very rare and the authors did not find in the literature a similar case operated sucessfully. The difficulties for dignosis are discussed. The possibility exists that in other cases with bilateral tumors a complete diagnosis is impossible if angiography is performed only in one side. Therefore, it is necessary to perform a bilateral angiographic study when a tumor of the choroid plexus is suspected. The surgical treatment and the mortality rate are also discussed.

  1. Síndrome do nevus organóide: relato de caso Organoid nevus syndrome: case report

    Directory of Open Access Journals (Sweden)

    Priscilla Luppi Ballalai

    2001-08-01

    Full Text Available Os autores apresentam um caso de uma criança com síndrome do nevus organóide, que se caracteriza pela presença de uma lesão epibulbar em olho direito, associada a nevus sebáceo de Jadassohn em couro cabeludo e cisto de aracnóide na fossa temporal. O exame anatomopatológico da lesão ocular revelou a presença de tecidos de origem ectodérmica e mesodérmica, levando ao raro diagnóstico de coristoma epibulbar complexo. A síndrome é raramente descrita na literatura oftalmológica. São feitas considerações a respeito das alterações oftalmológicas e sistêmicas associadas a esta síndrome.The authors present a case of a child with organoid nevus syndrome, characterized by epibulbar choristoma in the right eye, Jadassohn's nevus sebaceous in the scalp and arachnoid cist. The pathology of the ocular lesion revealed a mixture of ectodermal and mesodermal elements, leding to the rare diagnosis of epibulbar complex choristoma.The syndrome is rarely described in the ophthalmologic literature. Some considerations are made regarding ophthalmologic and systemic associations.

  2. 75 FR 8117 - Prohibited Transaction Exemptions and Grant of Individual Exemptions involving: 2010-01; Deutsche...

    Science.gov (United States)

    2010-02-23

    ... its business as global custodian. (f) The decision to select Deutsche Bank or its affiliate as the... Employee Benefits Security Administration Prohibited Transaction Exemptions and Grant of Individual... Mellon), D-11571 AGENCY: Employee Benefits Security Administration, Labor. ACTION: Grant of Individual...

  3. 50 CFR 600.745 - Scientific research activity, exempted fishing, and exempted educational activity.

    Science.gov (United States)

    2010-10-01

    ... subpart E. An applicant may be required to waive the right to confidentiality of information gathered... required to waive the right to confidentiality of information gathered while conducting exempted... written application that includes, but is not limited to, the following information: (i) The date of the...

  4. In-Home Performance of Exempt Pellet Stoves in Medford, Oregon.

    Energy Technology Data Exchange (ETDEWEB)

    Barnett, Stockton G.; Fields, Paula G.

    1991-07-05

    Pellet stoves that are considered exempt'' operate at an air-to-fuel ratio in excess of 35:1. They therefore qualify for exemption from the emissions certification process. A primary goal of this project was to determine how a sample of such stoves, operated in homes, would perform compared to their certified cousins,'' which were evaluated the previous year. In-home performance data documenting emissions from exempt stoves and net delivered efficiencies was particularly desired. This project evaluated six pellet stoves representing three major brands in Medford, Oregon. There were three Breckwell model P24FS, one Horizon Eclipse, one Horizon Destiny, and one Earth Stove TP40. The stoves were monitored for four week-long intervals in January and February 1991, for a total of 24 tests. Evaluations were conducted for particulate, CO (carbon monoxide) and PAH (polycyclic aromatic hydrocarbon) emissions and net efficiency. Monitoring was conducted using the AWES (automated woodstove emissions sampler) sampling system. A new data logger, developed for this project, was used to control the AWES and record real time data. 22 refs., 17 figs., 6 tabs.

  5. Legislative Exclusions or Exemptions of Property from the Insolvent Estate

    Directory of Open Access Journals (Sweden)

    RG Evans

    2011-08-01

    Full Text Available The general policy in South African insolvency law is that assets must be recovered and included in the insolvent estate, and that this action must be to the advantage of the creditors of the insolvent estate. But there are several exceptions to this rule and an asset that is the subject of such an exception may be excluded from the insolvent estate. The Insolvency Act, however, does not expressly distinguish between excluded and exempt assets, thereby resulting in problem areas in the field of exemption law in insolvency in South Africa. It may be argued that the fundamental difference between excluded and exempt assets is that excluded assets should never form part of an insolvent estate and should be beyond the reach of the creditors of the insolvent estate, while exempt assets initially form part of the insolvent estate, but in certain circumstances may be exempted from the estate for the benefit of the insolvent debtor, thereby allowing the debtor to use such excluded or exempt assets to start afresh before or after rehabilitation. Modern society, sociopolitical developments and human rights requirements have necessitated a broadening of the classes of assets that should be excluded or exempted from insolvent estates. This article considers assets excluded from the insolvent estates of individual debtors by legislation other than the Insolvency Act. It must, however, be understood that these legislative provisions relate to insolvent estates and thus generally overlap in one way or another with some provisions of the Insolvency Act.

  6. Aids e estomatite aftóide recidivante AIDS and recurrent aphtous stomatitis

    Directory of Open Access Journals (Sweden)

    Ivan Dieb Miziara

    2005-08-01

    Full Text Available O estado de imunodeficiência em pacientes HIV positivos tem sido causa de episódios severos de Estomatite Aftóide Recidivante (EAR. OBJETIVO: Este estudo objetiva estabelecer evidências da relação entre o surgimento (ou agravamento de EAR com o estado de imunossupressão causado pelo vírus HIV, por meio da contagem de células CD4+, CD8+ e da carga viral infectante. FORMA DE ESTUDO: estudo de série. MATERIAL E MÉTODO: Noventa e quatro pacientes HIV (1-positivos (25 mulheres e 69 homens com EAR foram acompanhados no ambulatório de Aids da Divisão de Clínica ORL do Hospital das Clínicas da FMUSP no período de janeiro de 1998 a dezembro de 2003. A idade dos pacientes variou de 19 a 63 anos (média = 35,3 anos. RESULTADO: Os pacientes com Aids e soropositivos apresentaram, respectivamente, oito aftas e duas aftas por surto. Da mesma maneira, os pacientes portadores de úlceras do tipo major apresentaram menor contagem de células CD8+, CD4+ e relação CD4+/CD8+ e maior valor médio da carga viral do que os pacientes portadores de aftas herpetiformes e minor. Entre os portadores de aftas minor e herpetiforme não houve diferença estatística. CONCLUSÕES O aparecimento das lesões, principalmente as do tipo major, está diretamente relacionado ao estado imunitário do paciente soropositivo, acarretando déficits nutricionais e piora na qualidade de vida. Desta forma, o diagnóstico e tratamento da EAR é um desafio que não deve ser desprezado.The immunodeficiency state in HIV infected patients has been the cause of severe episodes of Recurrent Aphthous Stomatitis (RAS. AIM: Our study aims to establish correlation between the manifestations of RAS and the immunosuppression state caused by HIV infection, through counting of CD4+ cells, CD8+ cells, CD4+:CD8+ cells ratio and viral load. STUDY DESIGN: series study. MATERIAL AND METHOD: Ninety-four HIV infected patients (25 women and 69 men with RAS were evaluated in the ENT Department of

  7. Molecular basis of Acute Myelogenous Leukemia As bases moleculares da leucemia mielóide aguda

    Directory of Open Access Journals (Sweden)

    Eduardo M. Rego

    2002-01-01

    Full Text Available Acute Myelogenous Leukemia (AML is frequently associated with recurring chromosomal translocations, which lead to the fusion of two genes encoding transcription factors. As the moieties of these fusion proteins retain part of the functional domains of the wild-type proteins, they may interfere directly or indirectly with the transcriptional regulation of the leukemic cell, conferring survival advantage. The majority of the transcription factors commonly involved in recurring chromosomal translocations may be grouped in one of the following families: core binding factor (CBF, retinoic acid receptor alpha (RARalpha, homeobox (HOX family, and mixed lineage leukemia (MLL. In vivo analysis of the molecular basis of leukemogenesis through the generation of transgenic mouse models revealed that a common theme is the recruitment of transcriptional co-activators and co-repressors by these fusion proteins. However, the expression of the fusion protein is not sufficient to induce full blown leukemia, as evidenced in part by the long latencies required for disease development in the transgenic models of leukemia, and therefore, second mutagenic events may contribute to AML pathogenesis.A leucemia mielóide aguda (LMA está freqüentemente associada a translocações cromossômicas recorrentes. Em muitos casos, os genes presentes nos pontos de quebra cromossômica são conhecidos e, quase todos codificam para fatores de transcrição. O gene híbrido, resultante da justaposição de exons de genes distintos, codifica para proteínas de fusão. Como estas retêm a maior parte dos domínios funcionais das proteínas selvagens, elas interferem direta ou indiretamente com regulação da transcrição gênica, conferindo vantagem à sobrevivência das células leucêmicas. A maioria dos fatores de transcrição afetados pelas translocações cromossômicas associadas a LMA pode ser agrupada numa das seguintes famílias: dos core binding factors (CBF, do receptor

  8. Alterações vasculares na coróide de ratos diabéticos tratados e não tratados Choroidal vessels alterations in treated and untreated diabetic rats

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Lottelli Rodrigues

    2007-06-01

    Full Text Available OBJETIVO: Conhecer os efeitos do diabetes e o impacto de seu tratamento medicamentoso em curto e longo prazo sobre os vasos da coróide e membrana de Bruch. MÉTODOS: Foram estudados 30 ratos Wistar, divididos em 3 grupos experimentais: grupo controle (GC, grupo diabético (GD e grupo diabético tratado (GT, estudados 1 mês (momento M1 e 12 meses (momento M2 após o início do experimento. O diabetes foi induzido por aloxana endovenosa, na dose de 42 mg/kg. O GT foi tratado com hipoglicemiante oral (acarbose e insulina subcutânea. Após o sacrifício, os olhos foram preparados para exame ao microscópio eletrônico de transmissão, interessando a ultra-estrutura da membrana de Bruch e os vasos da coróide. RESULTADOS: O exame ultra-estrutural da coróide dos ratos diabéticos mostrou depósitos na membrana de Bruch, acúmulo de vesículas, glicogênio e corpos densos no citoplasma das células endoteliais. O grupo mais afetado foi de ratos diabéticos de 12 meses (GDM2. Os animais com menor intensidade de alterações foram os ratos tratados por 12 meses (GTM2. CONCLUSÃO: Os ratos diabéticos desenvolveram alterações degenerativas na membrana de Bruch e vasos da coróide. Estas alterações foram mais evidentes nos animais submetidos à doença crônica, mas também ocorreram agudamente. O tratamento a curto prazo não foi capaz de evitar os processos degenerativos. A longo prazo, o tratamento inibiu a progressão destes processos.PURPOSE: To evaluate the diabetic alterations and the impact of short and long-term medical treatment on them. METHODS: Thirty Wistar rats were divided into 3 groups: control (GC, diabetic (DG, and treated diabetic (TG and the observations were made 1 month (M1 and 12 months (M2 after diabetes induction. Diabetes was induced by intravenous alloxan (42 mg/kg. The treated group received acarbose orally and insulin by subcutaneous injection. Eyes were prepared for transmission electron microscopy, specifically for

  9. 36 CFR 1202.90 - What NARA systems of records are exempt from release under the National Security Exemption of the...

    Science.gov (United States)

    2010-07-01

    ... are exempt from release under the National Security Exemption of the Privacy Act? 1202.90 Section 1202... from release under the National Security Exemption of the Privacy Act? (a) The Investigative Case Files... interfere with ongoing investigations and law enforcement or national security activities and impose an...

  10. 26 CFR 31.3121(k)-4 - Constructive filing of waivers of exemption from social security taxes by certain tax-exempt...

    Science.gov (United States)

    2010-04-01

    ... from social security taxes by certain tax-exempt organizations. 31.3121(k)-4 Section 31.3121(k)-4... filing of waivers of exemption from social security taxes by certain tax-exempt organizations. (a... provision of prior law) for purposes of section 210(a)(8)(B) of the Social Security Act and section 3121(b...

  11. Diagnóstico laboratorial das leucemias mielóides agudas Laboratory diagnosis of acute myeloid leukemias

    Directory of Open Access Journals (Sweden)

    Graziele C. da Silva

    2006-04-01

    Full Text Available As leucemias agudas caracterizam-se pela proliferação clonal e pelo bloqueio maturativo das células hematopoéticas, com substituição difusa da medula óssea por células neoplásicas. A leucemia mielóide aguda (LMA é um grupo heterogêneo de doenças clonais do tecido hematopoético, que acomete predominantemente idosos acima de 60 anos de idade. A LMA apresenta oito subtipos distintos morfologicamente: LMA M0 a M7. Os métodos diagnósticos para identificação da LMA e classificação dos subtipos são baseados em critérios morfológicos, citoquímicos e de imunofenotipagem, acrescidos de análise genética. Além de ser importante para a diferenciação do tipo da linhagem da leucemia, se mielóide (LMA ou linfóide (LLA, o diagnóstico é também de grande importância para identificar a leucemia bifenotípica aguda (BAL. O objetivo deste trabalho foi realizar uma revisão bibliográfica sobre LMA, dando ênfase aos métodos laboratoriais utilizados para a sua identificação e diferenciação.The acute leukemias are characterized by the clonal proliferation and maturative blockage of hematopoietic cells, with diffuse substitution of the bone marrow by neoplasic cells. The acute myeloid leukemia (AML is a heterogeneous group of clonal disease in the hematopoietic tissue and predominantly affects people older than 60. The AML has eight morphologically different subtypes: AML M0 to M7. The diagnostic methods for identification of AML and subtypes classification are based on morphological, cytochemical and immunophenotyping patterns, besides genetic and molecular analyses. The diagnosis of leukemia is important to the lineage differentiation in AML or ALL and also for the identification of biphenotypic acute leukemia (BAL. The aim of this study was to perform a bibliographic review of AML, giving emphasis on laboratory methods useful for its identification and differentiation.

  12. Sinergismo potencial entre herbicidas inibidores do fotossistema II e da síntese de carotenóides

    Directory of Open Access Journals (Sweden)

    Kruse Nelson Diehl

    2001-01-01

    Full Text Available Herbicidas inibidores do transporte de elétrons na fotossíntese geram estresse oxidativo. Esse estresse normalmente é amenizado pela ação dos carotenóides que dissipam a energia acumulada na forma de calor. Assim, hipotetiza-se que misturas entre herbicidas inibidores do transporte de elétrons, em nível do fotossistema II, e inibidores da síntese de carotenóides possam resultar em sinergismo. O objetivo deste trabalho foi verificar a existência de sinergismo em misturas com herbicidas pertencentes aos dois mecanismos de ação acima mencionados. Para tanto, foram conduzidos dois experimentos: um, com a cultura do milho, nos EUA, em 1998; e outro com cultura da soja, no Brasil, em 1998/99. No experimento com milho, testou-se isoxaflutole nas doses de 0 e 52,5g ha-1 e atrazine nas doses de 0 e 840g ha-1, isolados e em mistura. No experimento com soja, testou-se metribuzin, nas doses de 0 e 280g ha-1, e clomazone, nas doses de 0 e 560g ha-1, isolados e em mistura, bem como tratamentos adicionais isolados de metribuzin 560g ha-1, clomazone 1.120g ha-1 e testemunha capinada. Na cultura do milho, foram avaliadas as densidades de Abutilon theophrasti (ABUTH, Ipomoea hederacea (IPOHE e Amaranthus retroflexus (AMARE aos 52 dias após a aplicação dos herbicidas (DAA e o rendimento de grãos de milho. Na cultura da soja, foram avaliadas aos 55 DAA, a porcentagem de cobertura e controle de Bidens pilosa (BIDPI, sua densidade aos 30 e 55 DAA, além de massa seca, área foliar e rendimento de grãos de soja. Os resultados indicaram a ocorrência de antagonismo entre os herbicidas, no controle de ABUTH e IPOHE, mas sinergismo entre os mesmos, quando se considera o rendimento de grãos de milho. Para BIDPI, verificou-se sinergismo entre os herbicidas nos percentuais de cobertura e controle, sem valores conclusivos nas demais variáveis. Conclui-se que, embora seja complexa a comprovação de sinergismo a campo, os resultados indicam, ao menos para

  13. Tratamento cirúrgico das fraturas do odontóide tipo II com parafuso anterior: análise de 15 casos

    Directory of Open Access Journals (Sweden)

    Dantas Fernando Luiz Rolemberg

    2002-01-01

    Full Text Available Apresentamos estudo retrospectivo dos resultados de 15 pacientes consecutivos, com fratura do odontóide tipo II P (fratura com traço oblíquo e deslocamento posterior e II N (fratura com traço horizontal na base do odontóide, segundo a classificação de Roy-Camille , que foram submetidos a fixação anterior direta do odontóide com parafuso. A série é composta por 13 homens e 2 mulheres, com idade variando entre 14 a 74 anos e período de acompanhamento de 6 a 36 meses (média 20 meses. Tivemos apenas uma complicação relacionada com a técnica cirúrgica: um parafuso mal posicionado necessitando de uma reoperação para ser reposicionado. Não houve óbito. Não houve saída nem quebra de parafuso. Obteve-se 94% de fusão óssea. Propomos que seja utilizada a classificação de Roy-Camille na seleção dos casos cirúrgicos de fraturas do odontóide, pois ela fornece uma abordagem cirúrgica específica para cada tipo de fratura.

  14. A análise do nível superficial da narrativa do filme "BLADE RUNNER: O CAÇADOR DE ANDRÓIDES de Ridley Scott"

    Directory of Open Access Journals (Sweden)

    Anna Maria Balogh

    1985-05-01

    Full Text Available No trabalho que apresentamos aqui, pretendemos testar a aplicabilidade do modelo de análise narrativa proposto pelo Groupe d'Entrevernes ("Analyse Semiotique des Textes" a um objeto fílmico específico: "BLADE RUNNER: 0 CAÇADOR DE ANDRÓIDES".

  15. La tradizione nella scienza il progresso scientifico come equilibrio dialettico tra idee innovatrici e tradizione in una raccolta di saggi inediti

    CERN Document Server

    Heisenberg, Werner

    1982-01-01

    In questa raccolta di saggi (inediti per l'Italia), da lui stesso selezionati poco prima della morte, Heisenberg analizza da varie angolazioni i rapporti tra progresso scientifico e tradizione : la storia della scienza è soprattutto una storia di idee, e da un giusto equilibrio dialettico tra i nuovi concetti e la tradizione, che costituisce la base ideale per discuterli, scaturisce il progress scientifico.

  16. Novos assinalamentos de nematóides de parte aérea (Aphelenchoides spp. em plantas de begônia no Brasil.

    Directory of Open Access Journals (Sweden)

    Claudio Marcelo G. Oliveira

    2006-06-01

    Full Text Available Os nematóides da parte aérea, Aphelenchoides besseyi e A. ritzemabosi, foram detectados causando lesões pardo-escuras em todo o limbo foliar de plantas de begônia (Begonia sp. no Brasil. rata-se da primeira ocorrência de A. besseyi parasitando essa planta ornamental.

  17. Uso de hidrocolóide e alginato de cálcio no tratamento de lesões cutâneas

    Directory of Open Access Journals (Sweden)

    Luciane da Silva Pinheiro

    Full Text Available Hidrocolóide e alginato de cálcio são utilizados no tratamento de lesões cutâneas e muitos profissionais da saúde desconhecem as evidências que sustentam sua indicação na cicatrização. Objetivou-se nesse estudo identificar evidências da ação da placa de hidrocolóide e alginato de cálcio no tratamento de lesão cutânea. Utilizou-se o método de revisão integrativa da literatura. Fizeram parte da amostra 12 estudos com nível de evidências I, II, III e IV, formados por pacientes com lesão cutânea tratada durante qualquer período de tempo com hidrocolóide placa ou alginato de cálcio. Os desfechos avaliados foram redução da área, cicatrização da lesão, taxa de cicatrização, tempo e infecção. Os resultados permitiram estabelecer três recomendações para o uso de hidrocolóide e nenhuma para uso de alginato de cálcio no tratamento de lesão crônica.

  18. Tagasipöördumine ja taktika : mängu idee 1960. aastate eesti kultuuris ja happening "Mannekeeni matmine" / Anu Allas

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2008-01-01

    Analüüsitakse ideed mängust kui loomingumeetodist ja sotsiaalse surutise leevendajast 1960. aastate eesti kultuuris, keskendudes korraldatud häppeningidele, mille loomisel on toetutud Tartu nn. teatriuuenduse meetoditele ja mille aluseks on Roger Caillois' kultuurilooline mänguteooria. Pikemalt Leonhard Lapini, Andres Toltsi ja Ando Keskküla korraldatud rituaalsest etteastest "Mannekeeni matmine" Kablis

  19. Vasculopatia livedóide: relato de caso com possível evidência de etiopatogenia neurovascular Livedoid vasculopathy: report of a case with evidence for a possible neurovascular etiopathogenesis

    Directory of Open Access Journals (Sweden)

    Neide Kalil-Gaspar

    2007-08-01

    Full Text Available A etiopatogênese da vasculopatia livedóide ainda hoje permanece indeterminada e, apesar de algumas etiologias aventadas, com freqüência elas não apresentam associação com a vasculopatia em seu curso. Os tratamentos descritos na literatura não apresentam resultados reproduzíveis. Relata-se caso de paciente de 42 anos, com vasculopatia livedóide e boa resposta ao tratamento pioneiro com a carbamazepina. A droga foi instituída diante das discretas evidências de inflamação, da inconstância dos achados relacionados às teorias sugeridas, da forte sintomatologia dolorosa e dos recentes relatos da participação neural na coagulação, que levaram os autores a considerar a possibilidade de associação vasculoneural na patogênese dessa vasculopatia.Etiopathogenesis of livedoid vasculopathy remains elusive, and this condition is still frequently designated as idiopathic or secondary to various disorders. While several etiologies have been proposed, neither are they always associated with the disease, nor do they necessarily include livedoid vasculopathy in their course. Moreover, treatments described in the literature do not present reproducible results. We present the case of a 42-year-old man with livedoid vasculopathy who presented a good response to treatment with carbamazepine, a previously unattempted approach. In view of the very scarce evidence for vascular inflammation, discrepancies in the proposed etiologies of this pathological state and the intense pain that is the hallmark symptom; and considering recent reports on the neural participation in coagulation processes, the authors here address the question of a potential association between the vascular and nervous systems in the etiology of this vasculopathy.

  20. Process

    Energy Technology Data Exchange (ETDEWEB)

    Geenen, P.V.; Bennis, J.

    1989-04-04

    A process is described for minimizing the cracking tendency and uncontrolled dimensional change, and improving the strength of a rammed plastic refractory reactor liner comprising phosphate-bonded silicon carbide or phosphate-bonded alumina. It consists of heating the reactor liner placed or mounted in a reactor, prior to its first use, from ambient temperature up to a temperature of from about 490/sup 0/C to about 510/sup 0/C, the heating being carried out by heating the liner at a rate to produce a temperature increase of the liner not greater than about 6/sup 0/C per hour.

  1. User fee exemptions and excessive household spending for normal delivery in Burkina Faso: the need for careful implementation

    Directory of Open Access Journals (Sweden)

    Ameur Amal

    2012-11-01

    Full Text Available Abstract Background In 2006, the Parliament of Burkina Faso passed a policy to reduce the direct costs of obstetric services and neonatal care in the country’s health centres, aiming to lower the country’s high national maternal mortality and morbidity rates. Implementation was via a “partial exemption” covering 80% of the costs. In 2008 the German NGO HELP launched a pilot project in two health districts to eliminate the remaining 20% of user fees. Regardless of any exemptions, women giving birth in Burkina Faso’s health centres face additional expenses that often represent an additional barrier to accessing health services. We compared the total cost of giving birth in health centres offering partial exemption versus those with full exemption to assess the impact on additional out-of-pocket fees. Methods A case–control study was performed to compare medical expenses. Case subjects were women who gave birth in 12 health centres located in the Dori and Sebba districts, where HELP provided full fee exemption for obstetric services and neonatal care. Controls were from six health centres in the neighbouring Djibo district where a partial fee exemption was in place. A random sample of approximately 50 women per health centre was selected for a total of 870 women. Results There was an implementation gap regarding the full exemption for obstetric services and neonatal care. Only 1.1% of the sample from Sebba but 17.5% of the group from Dori had excessive spending on birth related costs, indicating that women who delivered in Sebba were much less exposed to excessive medical expenses than women from Dori. Additional out-of-pocket fees in the full exemption health districts took into account household ability to pay, with poorer women generally paying less. Conclusions We found that the elimination of fees for facility-based births benefits especially the poorest households. The existence of excessive spending related to direct costs of

  2. O papel da imunofluorescência direta na fisiopatologia e no diagnóstico diferencial da estomatite aftóide recorrente The role of immunoflorescence in the physiopathology and differential diagnosis of recurrent aphthous stomatitis

    Directory of Open Access Journals (Sweden)

    Niels Salles Willo Wilhelmsen

    2008-06-01

    Full Text Available A estomatite aftóide recorrente é doença caracterizada por aparecimento periódico de aftas na mucosa oral, cuja etiologia e fisiopatologia não estão bem explicadas. Estudos recentes com imunofluorescência direta mostram resultados controversos. Alguns revelam que o distúrbio básico está relacionado à imunidade humoral, enquanto outros apontam alterações da imunidade celular. Formas atípicas de estomatite aftóide podem fazer diagnóstico diferencial com doenças vésico-bolhosas como pênfigo vulgar. OBJETIVO: Verificar a presença de imunecomplexos na mucosa de pacientes com estomatite aftóide e utilidade do método no diagnóstico diferencial com dermatopatias bolhosas. CASUÍSTICA E MÉTODO: 23 pacientes portadores de estomatite aftóide, de modo prospectivo, foram incluídos no estudo. Todos foram submetidos à biópsia de mucosa sob anestesia local para retirada de dois fragmentos. Um deles foi enviado para exame histológico e, outro, para ser realizada a imunofluorescência direta. RESULTADOS: As 23 amostras no exame histológico revelaram processo inflamatório inespecífico ulcerado. As amostras enviadas para imunofluorescência resultaram negativas e apenas uma revelou presença de complemento em membrana basal. CONCLUSÃO: Baseado em nossos resultados, concluímos que pacientes portadores de EAR não apresentam depósitos de imunecomplexos na mucosa da cavidade bucal e a imunofluorescência é útil no diagnóstico diferencial entre a doença e dermatopatias bolhosas.Recurrent aphthous stomatitis (RAS is a disease characterized by the periodic appearance of aphthous lesions on the oral mucosa, of which etiology and physiopathology are not well explained. Recent studies with direct immunofluorescence show controversial results. Some reveal that the basic disorder is associated with humoral immunity, while others point to changes in cellular immunity. Atypical forms of aphthous stomatitis may have its differential

  3. HPV in oral squamous cell carcinomas of a Brazilian population: amplification by PCR HPV em carcinoma epidermóide de boca em população brasileira: amplificação por PCR

    Directory of Open Access Journals (Sweden)

    Elena Riet Correa Rivero

    2006-03-01

    Full Text Available Human Papilomaviruses (HPV are a group of viruses associated with benign and malignant lesions of cutaneous and mucosal epithelia. Some "high risk" HPV types, especially HPV 16 and 18, are strongly correlated with cervical and anogenital cancers and are also related to the genesis of oral squamous cell carcinomas (OSCC. The aim of this work was to investigate the incidence of HPV infection in 40 paraffin-embedded or fresh specimens of OSCC, using PCR amplification of the viral DNA. Literature based primers (GP5+/GP6+ were used in order to amplify HPV DNA from the L1 gene, present in more than 22 types of HPV. A condyloma case with HPV 16 and 18 detected by in situ hybridization was used as a positive control. Amplification of HPV was observed only in the positive control. No squamous cell carcinoma cases showed DNA viral amplification. Absence of HPV DNA amplification by PCR in the analyzed specimens of OSCCs suggests that this virus not always plays a role in the carcinogenesis process. Discrepancy with some studies found in the literature may be related to methodology or population differences.O papilomavírus humano (HPV constitui um grupo de vírus associados com lesões benignas e malignas do epitélio da pele e das mucosas. Alguns tipos de HPV, ditos oncogênicos, especialmente os HPVs 16 e 18, estão fortemente correlacionados com os cânceres cervical e anogenital, e também têm sido implicados na gênese do carcinoma epidermóide de boca. O objetivo deste estudo foi investigar a incidência de infecção pelo HPV, em 40 casos de carcinoma epidermóide de boca emblocados ou não em parafina, utilizando-se para isso a amplificação do DNA viral por PCR. Foram utilizados os iniciadores GP5+/GP6+, que amplificam parte da região L1 do vírus, comum a mais de 22 tipos de HPVs. Como controle positivo para as reações, foi utilizado um caso de condiloma, o qual foi positivo para os HPVs 16 e 18 na hibridização in situ. A amplifica

  4. Cisto de aracnóide e pseudotumor cerebral: relato de caso Arachnoid cyst and pseudotumor cerebri: case report

    Directory of Open Access Journals (Sweden)

    Nilton Domingos Cabral

    1996-06-01

    Full Text Available Relato do caso de paciente de 12 anos de idade com cisto de aracnóide na fossa craniana posterior e pseudotumor cerebral dependente de derivação cisto-peritoneal previamente instalada. Esta constatação corrobora assertivas da literatura que sugerem um mecanismo fisiopatológico em comum para estas duas entidades e que estaria relacionado a defeito no fluxo do líquido cefalorraqueano.Report on a 12 years old patient with an arachnoid cyst of posterior cranial fossa and pseudotumor cerebri. This patient is a shunt dependent of his cyst-peritoneal shunt. This association and evolution of this pacient suggest a common and specifical pathogenic mechanism of these two pathologies based in a disturbance of the cerebral fluid circulation.

  5. Diagnóstico laboratorial das leucemias mielóides agudas Laboratory diagnosis of acute myeloid leukemias

    OpenAIRE

    Graziele C. da Silva; Diogo A. Pilger; Simone M. de Castro; Wagner,Sandrine C.

    2006-01-01

    As leucemias agudas caracterizam-se pela proliferação clonal e pelo bloqueio maturativo das células hematopoéticas, com substituição difusa da medula óssea por células neoplásicas. A leucemia mielóide aguda (LMA) é um grupo heterogêneo de doenças clonais do tecido hematopoético, que acomete predominantemente idosos acima de 60 anos de idade. A LMA apresenta oito subtipos distintos morfologicamente: LMA M0 a M7. Os métodos diagnósticos para identificação da LMA e classificação dos subtipos são...

  6. Efeito apoptótico do Celecoxib em linhagens celulares derivadas de carcinoma epidermóide de boca

    OpenAIRE

    Aluana Maria da Costa Dal Vechio

    2011-01-01

    O Celecoxib, antiinflamatório não esteroidal, inibidor seletivo da COX-2, tem se mostrado um importante agente anticarcinogênico, mas o seu papel no carcinoma epidermóide de boca (CEB) não é totalmente compreendido. Sabe-se que diversas alterações genéticas estão associadas à patogênese do CEB, a neoplasia maligna mais comum de cabeça e pescoço. Algumas dessas alterações comprometem proteínas pertencentes à via de sinalização do Akt, envolvida em diferentes fenômenos celulares. É sabido que A...

  7. L'evoluzione della fisica sviluppo delle idee dai concetti iniziali alla relatività e ai quanti

    CERN Document Server

    Einstein, Albert

    1965-01-01

    Pubblicato in inglese alla vigilia della Seconda guerra mondiale e subito proposto in traduzione, L’evoluzione della fisica dovette aspettare la fine del conflitto per vedere la sua pubblicazione in Italia. Da allora (1948) questo testo non ha più smesso di rappresentare un punto di riferimento obbligato per il concetto stesso di divulgazione scientifica e per la fisica in particolare. Scritto dai protagonisti assoluti della rivoluzione della fisica relativistica e quantistica, ma destinato a un pubblico di non specialisti, il libro che avete tra le mani è il testo fondativo della moderna divulgazione delle idee, la pietra di paragone di ogni altro libro di fisica, che permette di intuire la straordinaria importanza e il valore rivoluzionario della svolta della fisica del Novecento.

  8. Considerações sobre efeitos do uso de esteróides anabólicos androgênicos.

    OpenAIRE

    Amaral, Waleska Cláudia Dornas; Nagem, Tanus Jorge; Oliveira, Tânia Toledo de

    2006-01-01

    Esteróides Anabólicos Androgênicos (EAA) são um grupo de compostos naturais e sintéticos formados pela testosterona e seus derivados. Os efeitos androgênicos de qualquer hormônio são ligados às características sexuais associadas à masculinidade, enquanto que os efeitos anabólicos estão relacionados ao estado em que o nitrogênio é diferencialmente retido na massa corporal magra, através da estimulação da síntese protéica e/ou decréscimo do catabolismo protéico. Embora usados indiscriminadament...

  9. Metabolômica da resistência ao metotrexato na leucemia linfóide aguda

    OpenAIRE

    Rafael Renatino Canevarolo

    2012-01-01

    Resumo: O uso intensivo e combinado de diferentes quimioterápicos tem permitido a cura de 70-80% das leucemias linfóides agudas (LLA) da infância, sendo que a recaída da doença decorre em grande parte da resistência intrínseca das células leucêmicas à quimioterapia. Alguns dos quimioterápicos utilizados na LLA são inibidores metabólicos, como o metotrexato (MTX), antagonista do ácido fólico, que impede a divisão celular ao inibir a síntese de nucleotídeos. Em uma abordagem metabolômica, foi i...

  10. APLICAÇÃO DA FONOFORESE NO TRATAMENTO DO FIBRO EDEMA GELÓIDE NA REGIÃO ABDOMINAL

    Directory of Open Access Journals (Sweden)

    Ohanna Daher de Paula FELIPE

    2015-12-01

    Full Text Available O objetivo desta pesquisa foi analisar os efeitos do ultrassom terapêutico de 3MHz associado a fonoforese na redução do fibro edema gelóide na região abdominal. Para tal realizou-se uma pesquisa experimental do tipo estudo de caso. O estudo foi realizado com uma paciente do sexo feminino, de30anos, com quadro de FEG graus 1 e 2 na região abdominal. Foram utilizados uma ficha de avaliação específica para fibro edema gelóide e registro fotográfico. A paciente foi submetida a 20 sessões de tratamento, realizando 3 vezes por semana, com duração de 24 minutos de ultrassom. O protocolo do US utilizado neste estudo foi frequência de 3 MHz, com intensidade de 0,6 w/cm², modo contínuo, associado a fonoforese com uma substância de acoplamento, em forma de gel, composto por arnica, algas marinhas, centella asiática, castanha da índia, cavalhinha, hera, erva mate, laranja amarga, chá verde, gengibre e L-carnitina, fabricado pela Buonavita cosméticos. Ao final do tratamento foi possível observar melhora no quadro de FEG, melhora no aspecto da pele e satisfação da paciente com os resultados. Com isso, conclui-se que o ultrassom associado à fonoforese pode ser benéfico no tratamento do FEG, provando ser um recurso eficaz na diminuição do aspecto do mesmo.

  11. Dall’auctoritas all’autore e ritorno Fonti e circolazione dei saperi tra storia delle idee e della lettura

    Directory of Open Access Journals (Sweden)

    Riccardo Fedriga

    2012-06-01

    Full Text Available Che cosa si intende, oggi, per fonte? La domanda non mira alla ricostruzione e definizione di una presunta entità sovrastorica. Essa è da intendere piuttosto come spia, nel variare delle forme storiche, di una persistenza delle questioni legate alla circolazione e al controllo dei saperi, anche in un epoca segnata da profondi mutamenti nei media della comunicazione intellettuale. L'articolo ha inteso indagarne alcuni aspetti, quali l''accesso all'informazione sul web, le nuove forme online dell'enciclopedia del sapere e i nuovi oggetti culturali (ebook, nel quadro di una storia delle idee e della lettura che mostrasse, attraverso alcuni casi emblematici, le dinamiche di azione e reazione tra rivendicazioni di una libera circolazione delle idee e istanze di controllo. Il filo della riflessione si muove quindi alla ricerca di analogie che aiutino a decifrare alcuni fenomeni contemporanei e le questioni epistemologiche che ne derivano, dalle auctoritates dei secoli medievali al problema dell'autorevolezza delle fonti online. What can we mean, talking about sources today? The question doesn't aim at the definition of a presumed overhistorical object. We must rather think of it as a sign, in the changing of historical forms, of the persistence of questions connected to circulation and control of knowledge, in an age of deep changes concerning media. The paper would investigate some aspects of the question, like access to the web information, online versions of classical encyclopedia and new supports for reading (like ebook, in a history of ideas context able to show, using some historical examples, the dynamics of acting and reacting between claimings of free circulation of opinions and the attempt to put them down. Definitively, these pages try to find analogies to understand some issues of our age and some epistemological problems, driving the reader from the auctoritas concept in the Middle Ages to the authority of online sources.

  12. Diversidade de pulgões e de seus parasitóides e predadores na cultura da alfafa

    Directory of Open Access Journals (Sweden)

    MENDES SIMONE

    2000-01-01

    Full Text Available O objetivo deste trabalho foi verificar a diversidade de pulgões, seus predadores e parasitóides, e a influência de fatores climáticos nas suas populações. Foram realizadas coletas semanais no período de abril/1995 a março/1996, no campo de alfafa da Universidade Federal de Lavras (UFLA, em Lavras, MG. As espécies de pulgões coletadas foram Therioaphis trifolii (Monel f. maculata, Acyrthosiphon pisum (Harris, A. kondoi Shinji e Aphis craccivora Kock, presentes na cultura durante todo o período de estudo, com picos populacionais em novembro/1995, julho/1995, dezembro/1995 e abril/1996, respectivamente. Foram amostrados insetos predadores das famílias Coccinellidae, Syrphidae, Anthocoridae, Geocoridae e Chrysopidae, tendo as duas últimas ocorrência esporádica. Espécies da família Coccinellidae ocorreram durante todo o período amostral, apresentando o pico populacional no final de dezembro/1995, com precipitação de 20 mm e temperatura de 22,6ºC. A família Syrphidae alcançou maiores números em abril, à precipitação de 53 mm e temperatura de 21ºC. A família Anthocoridae não se manteve por todo o período amostral, porém um pico populacional ocorreu no final de dezembro nas mesmas condições que aquele apresentado pela família Coccinellidae. Os parasitóides da família Aphididae alcançaram pico em junho/1995, à temperatura de 16ºC.

  13. Acesso endoscópico transepto-interforniceal para cistos colóides: relato de caso

    Directory of Open Access Journals (Sweden)

    VIALOGO JOSUÉ GUIMARÃES GRANHA

    2000-01-01

    Full Text Available A abordagem endoscópica de cistos colóides ainda é matéria controversa. As opções de tratamento são variadas: observação com exames seriados, tratamento da hidrocefalia, aspiração por estereotaxia, microcirurgia e endoscopia. O autor relata o caso de um paciente com cisto colóide do terceiro ventrículo, localizado em posição retroforaminal, no teto diencefálico, dissecando os dois fornices projetando-se supero-posteriormente em direção ao assoalho do ventrículo lateral, por dentro do cavum do septo pelúcido. A lesão foi alcançada com neuroendoscópio rígido, através de um orifício de trépano pré-coronal situado a 2,5 cm da linha média (ponto de Kocher. Seguindo por via transventricular, a lâmina direita do septo pelúcido foi aberta, posterior à veia septal. A lesão, muito endurecida, situada entre os dois fórnices, foi parcialmente ressecada através da via endoscópica transventricular transepto-interforniceal. Realizamos também septostomia e terceiro ventriculostomia endoscópicas neste paciente. Os diferentes tipos de procedimentos cirúrgicos das patologias situadas no terceiro ventrículo são discutidos com ênfase no papel da endoscopia.

  14. Leucemia linfóide aguda: uma doença curável Acute lymphoblastic leukemia: a curable disease

    Directory of Open Access Journals (Sweden)

    Francisco Pedrosa

    2002-04-01

    Full Text Available RESUMO: Leucemia linfóide Aguda (LLA, é o tipo mais comum de câncer infantil, constituindo cerca de um terço de todas as neoplasias malignas da criança. A incidência de LLA em crianças nos Estados Unidos é aproximadamente de 3,4 casos por 100.000 crianças menores de 15 anos de idade. Até a metade do século passado, as leucemias eram consideras universalmene, uma doença fatal. O desenvolvimento de combinações terapêuticas, utilizando diversas drogas citotóxicas com ou sem transplante de medula óssea, tem aumentado o percentual de cura da criança portadora de Leucemia linfóide Aguda em mais de 80%. Anualmente cerca de 1.500 crianças com LLA, nos Estados Unidos, estão sendo curadas. Contudo, dos 75.000 novos casos de LLA, que são diagnosticados anualmente em todo o mundo, cerca de 60.000 (80% não têm acesso a essas modernas formas de tratamento e são, portanto excluídos desse processo de cura. O desafio de tornar a LLA uma doença curável começa a ser vencido com o relato de taxas de sobrevida maior que 50% para crianças tratadas em países com recursos limitados. Em El salvador, Bonilla, conseguiu aumentar a taxa de sobrevida de crianças com LLA de 5% para 50%. No Recife, Pernambuco, Brasil, Pedrosa evoluiu de uma taxa de 29% nos anos 80, para 75% na era atual.ABSTRACT: Acute lymphoblastic leukemia (ALL is the most common type of cancer in children, accoun-ting for one third of all malignant neoplasias affecting them. ALL incidences in children in the United States are of approximately 3,4 cases per 100.000 children under fifteen years old. Up to the middle of last century leukemia was universally considered a fatal di-sease. The development of therapeutic combinations through the use of various cytotoxic drugs with or without bone marrow transplantation has increased cure percentages of children with ALL in over 80%. Annually around 1.500 children with ALL in the Uni-ted States are being cured. Nevertheless, of the

  15. Mecanismos de ação dos corticosteróides na polipose rinossinusal Mechanism of action of glucocorticoids in nasal polyposis

    Directory of Open Access Journals (Sweden)

    Atílio Maximino Fernandes

    2008-04-01

    Full Text Available Os glicocorticóides (GC são drogas de escolha no tratamento clínico da polipose nasossinusal conforme recomendação da literatura. Entretanto, seus mecanismos de ação nas regressões dos sintomas clínicos e dos pólipos não são totalmente compreendidos. Sabe-se que a administração tópica e ou sistêmica dos glicocorticóides leva a variações na expressão de citocinas, quimiocinas e linfocinas, além das alterações celulares. Assim, os GC suprimem a expressão de citocinas pró-inflamatórias, de quimiocinas, de moléculas de adesão, além de estimular a transcrição de citocinas antiinflamatórias. Citocinas pró-fibróticas como a IL-11, fator básico de crescimento do fibroblasto (b-FGF e fator de crescimento endotelial vascular (VEGF, relacionados com o crescimento do pólipo, também são suprimidos pela ação do GC. Tal ação depende fundamentalmente da interação com os seus receptores (GR, pois alguns indivíduos apresentam algum grau de resistência celular ao seu efeito, que parece estar relacionada com a presença da isoforma b do GR. Genes envolvidos nas fases de produção de imunoglobulinas, apresentação e processamento do antígeno também sofrem ação dos GC de forma variada. OBJETIVOS: Fazer uma revisão da literatura sobre os mecanismos de ação do GC na PNS. CONCLUSÃO: A compreensão desses mecanismos implicará no desenvolvimento de drogas mais eficazes na sua terapêutica.Glucocorticoids (GC are the drugs of choice for the clinical treatment of nasal polyposis, according to the medical literature. Its mechanism of action in the regression of clinical symptoms and polyps, however, is not fully understood. The topical and/or systemic use of glucocorticoids lead to variable expression of cytokines, chemokines and lymphokines, as well as changes in cells. It is known that GC suppresses the expression of pro-inflammatory cytokines, chemokines and adhesion molecules such as ICAM-1 and E-selectin; GC also

  16. 77 FR 43382 - Millstone Power Station, Unit 2; Exemption

    Science.gov (United States)

    2012-07-24

    ...: (1) The exemptions are authorized by law, will not present an undue risk to public health or safety... (i.e., welding, cutting, grinding) is also administratively controlled by site FPP procedure CM-AA...

  17. 75 FR 28684 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2010-05-21

    ... established medical history or clinical diagnosis of diabetes mellitus currently requiring insulin for control... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... prohibiting persons with insulin-treated diabetes mellitus (ITDM) from operating commercial motor vehicles...

  18. 75 FR 8182 - Qualification of Drivers; Exemption Applications; Diabetes

    Science.gov (United States)

    2010-02-23

    ... person has no established medical history or clinical diagnosis of diabetes mellitus currently requiring... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes... with insulin-treated diabetes mellitus (ITDM) from operating commercial motor vehicles (CMVs) in...

  19. 77 FR 65763 - Petition for Exemption; Summary of Petition Received

    Science.gov (United States)

    2012-10-30

    ... notice is to improve the public's awareness of, and participation in, this aspect of the FAA's regulatory... of Relief Sought: Exemption from the requirements of fuel-tank structural lightning protection ] for...

  20. 40 CFR 92.910 - Granting of exemptions.

    Science.gov (United States)

    2010-07-01

    ...), other than in strict conformity with all terms and conditions of this exemption, renders the person to... requirements and will not become effective until approval has been given by the Office of Management and Budget. ...

  1. 21 CFR 1310.12 - Exempt chemical mixtures.

    Science.gov (United States)

    2010-04-01

    ... § 1310.13 affects the criminal liability for illegal possession, distribution, exportation, or importation of listed chemicals contained in the exempt chemical mixture or the civil liability for unlawful...

  2. 77 FR 19748 - Petition for Exemption; Summary of Petition Received

    Science.gov (United States)

    2012-04-02

    ... would allow The Wright Experience, Inc., to operate its replica of the 1911 Wright Brother's glider at a... Director, Office of Rulemaking. Petition for Exemption Docket No.: FAA-2012-0119. Petitioner: The Wright...

  3. 22 CFR 123.26 - Recordkeeping requirement for exemptions.

    Science.gov (United States)

    2010-04-01

    ... LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.26 Recordkeeping requirement for exemptions. When an... each such export. The business record should include the following information: A description of the...

  4. 77 FR 74734 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-12-17

    ... C. Schmude (WI) Dennis J. Smith (CO) David C. Stitt (KS) Kevin L. Truxell (FL) Bruce A. Walker (WI) Lee A. Wiltjer (IL) The exemptions are extended subject to the following conditions: (1) That each...

  5. 75 FR 79083 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-12-17

    ... Tyrone Earl M. Vaughan McKneely James L. Houser Dennis N. Bruce A. Walker McQuiston Richard G. Isenhart Garth R. Mero Lee A. Wiltjer The exemptions are extended subject to the following conditions: (1) That...

  6. 32 CFR Appendix H to Part 323 - DLA Exemption Rules

    Science.gov (United States)

    2010-07-01

    ... required by the Executive Order to be kept secret in the interest of national defense or foreign policy...: Incident Investigation/Police Inquiry Files. 2. Exemption: (i) Investigatory material compiled for law...

  7. 48 CFR 9904.403-62 - Exemption. [Reserved

    Science.gov (United States)

    2010-10-01

    ... Section 9904.403-62 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST ACCOUNTING STANDARDS COST ACCOUNTING STANDARDS 9904.403-62 Exemption. ...

  8. 78 FR 46407 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-07-31

    ...,'' Journal of American Statistical Association, June 1971). A 1964 California Driver Record Study prepared by... applications, FMCSA exempts Deneris G. Allen (LA), Terry L. Baker (KY), Rocky B. Bentz (WI), Ryan L. Brown (IL...

  9. 41 CFR 101-39.107 - Limited exemptions.

    Science.gov (United States)

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet... incorporated in the fleet management system, if the exemption has been mutually agreed upon by the... of the fleet management system. ...

  10. 76 FR 21796 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-04-18

    ... decided to extend each exemption for a renewable two-year period. They are: Rex A. Botsford Curtis F.... Dare Christopher A. Deadman Vincent C. Durazzo, Jr. Jerald O. Edwards Breck L. Falcon Kenneth Flack, Jr...

  11. 78 FR 78479 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-12-26

    ... prohibition against persons with insulin- treated diabetes mellitus (ITDM) operating commercial motor vehicles... individual assessment of drivers with diabetes mellitus, and be consistent with the criteria described in... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes...

  12. 77 FR 64181 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-10-18

    ...; Diabetes Mellitus AGENCY: Federal Motor Carrier Safety Administration (FMCSA). ACTION: Notice of applications for exemption from the diabetes mellitus requirement; request for comments. SUMMARY: FMCSA... with insulin-treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate...

  13. 75 FR 57105 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-09-17

    ... decided to extend each exemption for a renewable two-year period. They are: Robert L. Aurandt; Harry R. Brewer; Joseph H. Fowler; Kelly R. Konesky; Gregory T. Lingard; Hollis J. Martin; Kevin C. Palmer...

  14. 76 FR 55460 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-09-07

    ...; Diabetes Mellitus AGENCY: Federal Motor Carrier Safety Administration (FMCSA). ACTION: Notice of applications for exemption from the diabetes mellitus standard; request for comments. SUMMARY: FMCSA announces... insulin-treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate commerce...

  15. 18 CFR 420.23 - Exempt uses under the Compact.

    Science.gov (United States)

    2010-04-01

    ... ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Water Supply Policy § 420.23 Exempt uses under the... surface water annually per acre irrigated. (d) Notwithstanding the provisions of paragraphs (a), (b) and... surface water of the basin. ...

  16. Effect on HBs antigen clearance of addition of pegylated interferon alfa-2a to nucleos(t)ide analogue therapy versus nucleos(t)ide analogue therapy alone in patients with HBe antigen-negative chronic hepatitis B and sustained undetectable plasma hepatitis B virus DNA: a randomised, controlled, open-label trial.

    Science.gov (United States)

    Bourlière, Marc; Rabiega, Pascaline; Ganne-Carrie, Nathalie; Serfaty, Lawrence; Marcellin, Patrick; Barthe, Yoann; Thabut, Dominique; Guyader, Dominique; Hezode, Christophe; Picon, Magali; Causse, Xavier; Leroy, Vincent; Bronowicki, Jean Pierre; Carrieri, Patrizia; Riachi, Ghassan; Rosa, Isabelle; Attali, Pierre; Molina, Jean Michel; Bacq, Yannick; Tran, Albert; Grangé, Jean Didier; Zoulim, Fabien; Fontaine, Hélène; Alric, Laurent; Bertucci, Inga; Bouvier-Alias, Magali; Carrat, Fabrice

    2017-03-01

    Findings from uncontrolled studies suggest that addition of pegylated interferon in patients with HBe antigen (HBeAg)-negative chronic hepatitis B receiving nucleos(t)ide analogues with undetectable plasma hepatitis B virus (HBV) DNA might increase HBs antigen (HBsAg) clearance. We aimed to assess this strategy. In this randomised, controlled, open-label trial, we enrolled patients aged 18-75 years with HBeAg-negative chronic hepatitis B and documented negative HBV DNA while on stable nucleos(t)ide analogue regimens for at least 1 year from 30 hepatology tertiary care wards in France. Patients had to have an alanine aminotransferase concentration of less than or equal to five times the upper normal range, no hepatocellular carcinoma, and a serum α fetoprotein concentration of less than 50 ng/mL, normal dilated fundus oculi examination, and a negative pregnancy test in women. Patients with contraindications to pegylated interferon were not eligible. A centralised randomisation used computer-generated lists of random permuted blocks of four with stratification by HBsAg titres (interferon alfa-2a in addition to the nucleos(t)ide analogue regimen or to continue to receive nucleos(t)ide analogues only. The primary endpoint was HBsAg loss at week 96 by intention-to-treat analysis. This trial is closed and registered with ClinicalTrials.gov, number NCT01172392. Between Jan 20, 2011, and July 18, 2012, we randomly allocated 185 patients (92 [50%] to pegylated interferon and nucleos(t)ide analogues and 93 [50%] to nucleos(t)ide analogues alone). We excluded two patients from the pegylated interferon plus nucleos(t)ide analogues group from analyses because of withdrawal of consent (one patient) or violation of inclusion criteria (one patient). At week 96, loss of HBsAg was reported in seven (7·8%) of 90 patients in the pegylated interferon plus nucleos(t)ide analogues group versus three (3·2%) of 93 in the nucleos(t)ide analogues-alone group (difference 4·6% [95% CI -2

  17. 78 FR 66769 - Proposed Exemptions From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2013-11-06

    ... Prohibited Transaction Exemptions (PTEs) 93-33 and 97- 11. PTE 93-33 \\3\\ permits an individual for whose... investments, provided the conditions of the exemption are met. 4. PTEs 93-33 and 97-11 provide relief from the... industry since PTEs 93-33 and 97-11 were issued. In this regard, the Applicant notes that PTEs 93-33 and 97...

  18. Estudo comparativo de testes diagnósticos para olho seco entre crianças saudáveis e portadoras de artrite reumatóide juvenil

    OpenAIRE

    Paula,Jayter Silva de; Bonini-Filho,Marco Antônio; Schirmbeck,Tarciso; Ferriani,Virginia Paes Leme; Rodrigues,Maria de Lourdes Veronese; Romão,Erasmo

    2004-01-01

    OBJETIVO: Comparar achados diagnósticos de olho seco em crianças normais e com artrite reumatóide juvenil. MÉTODOS: Neste estudo transversal, 30 olhos de 15 pacientes com artrite reumatóide juvenil (grupo 1) e 22 olhos de 11 crianças-controle (grupo 2) foram examinados clinicamente e submetidos a testes para ceratoconjuntivite seca: Schirmer tipo 1, tempo de quebra do filme lacrimal e coloração com rosa bengala. RESULTADOS: Seis crianças com artrite reumatóide juvenil apresentaram um ou mais ...

  19. Religious hiring exemption upheld: anatomy of a Supreme Court ruling.

    Science.gov (United States)

    Chopko, M E

    1988-01-01

    In 1980 the Church of Jesus Christ of the Latter-day Saints (LDS Church) notified five employees that they could no longer continue in church employment because they would not or could not attend the temple as members in good standing. Together, the five filed suit in federal district court in Utah, alleging that the LDS Church discriminated against them on religious grounds in violation of Title VII of the federal Civil Rights Act of 1964, which generally prohibits discrimination in employment on the basis of religion. The plaintiffs said the statutory exemption for religious organizations in Section 702 operated as a religious preference and penalized their personal choices of religion in violation of the First Amendment. The case ended up in the Supreme Court, which upheld the provision exempting religious organizations from Title VII with respect to employing people of a particular religion for all not-for-profit activities. Evidence in the case included: Legislative history. As first enacted in 1964, Section 702 provided a limited exemption to religious corporations. In 1972 Congress enacted a broader exemption, effectively exempting from the sweep of Title VII employment decisions made by religious employers with respect to members of that religion in any work connected with the religious corporation. District court proceedings. The Utah court borrowed from several earlier cases, including one that avoided the constitutional issue by deciding that the function challenged was uniquely religious and, thus, exempted. Briefs amicus curiae. Four religious organizations filed briefs amicus curiae.

  20. 77 FR 23756 - Grant of Individual Exemption Involving Renaissance Technologies, LLC (Renaissance, or the...

    Science.gov (United States)

    2012-04-20

    ...- 11655] Grant of Individual Exemption Involving Renaissance Technologies, LLC (Renaissance, or the... transactions involve Renaissance and certain of Renaissance's privately offered collective investment vehicles managed by Renaissance, comprised almost exclusively of proprietary funds. The individual exemption...

  1. Cancer Treatment Measures – PPS-Exempt Cancer Hospital

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Prospective Payment System (PPS)-Exempt Cancer Hospital Quality Reporting (PCHQR) Program currently uses three cancer specific measures. The resulting PPS-Exempt...

  2. Oncology Care Measures – PPS-Exempt Cancer Hospital

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Prospective Payment System (PPS)-Exempt Cancer Hospital Quality Reporting (PCHQR) Program currently uses five oncology care measures. The resulting PPS-Exempt...

  3. 29 CFR 779.302 - Exemptions depend on character of establishment.

    Science.gov (United States)

    2010-07-01

    ... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service... include the “retail or service establishment” exemptions in sections 13(a) (2), (4), and (11) and the...

  4. 78 FR 3420 - Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations

    Science.gov (United States)

    2013-01-16

    ... September 30, 2012. Contact: Debra Rate. New Jersey Department of Environmental Protection Crisis Exemption... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Pesticide Emergency Exemptions; Agency Decisions and State and Federal Agency Crisis Declarations...

  5. 48 CFR 22.1003-4 - Administrative limitations, variations, tolerances, and exemptions.

    Science.gov (United States)

    2010-10-01

    ... exemptions cited in 22.1003-3 of this subsection, the Secretary of Labor has exempted the following types of..., purchase cards, smart cards, and similar card services). (iii) Hotel/motel services for conferences...

  6. Transcriptome sequencing and analysis of wild Amur Ide (Leuciscus waleckii inhabiting an extreme alkaline-saline lake reveals insights into stress adaptation.

    Directory of Open Access Journals (Sweden)

    Jian Xu

    Full Text Available BACKGROUND: Amur ide (Leuciscus waleckii is an economically and ecologically important species in Northern Asia. The Dali Nor population inhabiting Dali Nor Lake, a typical saline-alkaline lake in Inner Mongolia, is well-known for its adaptation to extremely high alkalinity. Genome information is needed for conservation and aquaculture purposes, as well as to gain further understanding into the genetics of stress tolerance. The objective of the study is to sequence the transcriptome and obtain a well-assembled transcriptome of Amur ide. RESULTS: The transcriptome of Amur ide was sequenced using the Illumina platform and assembled into 53,632 cDNA contigs, with an average length of 647 bp and a N50 length of 1,094 bp. A total of 19,338 unique proteins were identified, and gene ontology and KEGG (Kyoto Encyclopedia of Genes and Genomes analyses classified all contigs into functional categories. Open Reading Frames (ORFs were detected from 34,888 (65.1% of contigs with an average length of 577 bp, while 9,638 full-length cDNAs were identified. Comparative analyses revealed that 31,790 (59.3% contigs have a significant similarity to zebrafish proteins, and 27,096 (50.5%, 27,524 (51.3% and 27,996 (52.2% to teraodon, medaka and three-spined stickleback proteins, respectively. A total of 10,395 microsatellites and 34,299 SNPs were identified and classified. A dN/dS analysis on unigenes was performed, which identified that 61 of the genes were under strong positive selection. Most of the genes are associated with stress adaptation and immunity, suggesting that the extreme alkaline-saline environment resulted in fast evolution of certain genes. CONCLUSIONS: The transcriptome of Amur ide had been deeply sequenced, assembled and characterized, providing a valuable resource for a better understanding of the Amur ide genome. The transcriptome data will facilitate future functional studies on the Amur ide genome, as well as provide insight into potential

  7. 21 CFR 1308.33 - Exemption of certain anabolic steroid products; application.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Exemption of certain anabolic steroid products... SCHEDULES OF CONTROLLED SUBSTANCES Exempt Anabolic Steroid Products § 1308.33 Exemption of certain anabolic... compound, mixture, or preparation containing an anabolic steroid as defined in part 1300 of this chapter...

  8. 10 CFR 32.18 - Manufacture, distribution and transfer of exempt quantities of byproduct material: Requirements...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Manufacture, distribution and transfer of exempt... COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL Exempt Concentrations and Items § 32.18 Manufacture, distribution and transfer of exempt quantities of...

  9. 29 CFR 784.109 - Manufacture of supplies for named operations is not exempt.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Manufacture of supplies for named operations is not exempt... § 784.109 Manufacture of supplies for named operations is not exempt. Employment in the manufacture of..., the exemption is not applicable to the manufacture of boxes, barrels, or ice by a seafood processor...

  10. 26 CFR 48.4041-20 - Partially exempt methanol and ethanol fuel.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Partially exempt methanol and ethanol fuel. 48... Partially exempt methanol and ethanol fuel. (a) In general. Under section 4041(m), the sale or use of partially exempt methanol or ethanol fuel is taxed at the rate of 41/2 cents per gallon of fuel sold or used...

  11. 29 CFR 1904.2 - Partial exemption for establishments in certain industries.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Partial exemption for establishments in certain industries... Partial exemption for establishments in certain industries. (a) Basic requirement. (1) If your business... company is partially exempted because of size under § 1904.1. (b) Implementation—(1) Does the partial...

  12. 41 CFR 102-85.130 - How are exemptions from Rent granted?

    Science.gov (United States)

    2010-07-01

    ... Rent granted? 102-85.130 Section 102-85.130 Public Contracts and Property Management Federal Property... OCCUPANCY IN GSA SPACE Rent Charges § 102-85.130 How are exemptions from Rent granted? Exemptions from Rent are rare. However, the Administrator of General Services may exempt any GSA customer from Rent after a...

  13. 78 FR 7479 - Qualification of Drivers; Application for Exemptions; National Association of the Deaf

    Science.gov (United States)

    2013-02-01

    ... exemption. William B. Britt, Jr. Mr. Britt holds a class D driver's license from the state of Tennessee... driving CMVs in interstate commerce, if granted an exemption. Allen W. Estes Mr. Estes holds a class B CDL..., if granted an exemption. William Edward Haab Mr. Haab holds a class D driver's license from the state...

  14. 17 CFR 250.5 - Exemption of certain foreign holding companies.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain foreign... and General Exemptions § 250.5 Exemption of certain foreign holding companies. Any holding company not... of the issuer, except an issuer within any class specified in § 250.10(a). ...

  15. 40 CFR 180.1244 - Ammonium bicarbonate; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Ammonium bicarbonate; exemption from... FOOD Exemptions From Tolerances § 180.1244 Ammonium bicarbonate; exemption from the requirement of a... bicarbonate used in or on all food commodities when used in accordance with good agricultural practices. ...

  16. 40 CFR 180.1289 - Candida oleophila Strain O; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Candida oleophila Strain O; exemption... FOOD Exemptions From Tolerances § 180.1289 Candida oleophila Strain O; exemption from the requirement... the microbial pesticide, Candida oleophila Strain O, on apples and pears when applied/used as a post...

  17. 40 CFR 80.606 - What national security exemption applies to fuels covered under this subpart?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What national security exemption... national security exemption applies to fuels covered under this subpart? (a) The standards of all the fuels..., including locomotive and marine, having an EPA national security exemption from the motor vehicle emission...

  18. 28 CFR 16.99 - Exemption of the Immigration and Naturalization Service Systems-limited access.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of the Immigration and....99 Exemption of the Immigration and Naturalization Service Systems-limited access. (a) The following systems of records of the Immigration and Naturalization Service are exempt from 5 U.S.C. 552a (c) (3) and...

  19. 77 FR 66912 - Soo Line Railroad Company-Abandonment Exemption-in Cook County, IL

    Science.gov (United States)

    2012-11-07

    ... Surface Transportation Board Soo Line Railroad Company--Abandonment Exemption--in Cook County, IL Soo Line Railroad Company, d/b/a Canadian Pacific (Soo Line) has filed a verified notice of exemption under 49 CFR part 1152 subpart F- Exempt Abandonments to abandon a 2.88 mile line of railroad between milepost 2.38...

  20. 40 CFR 180.1016 - Ethylene; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Ethylene; exemption from the requirement of a tolerance. 180.1016 Section 180.1016 Protection of Environment ENVIRONMENTAL PROTECTION... Exemptions From Tolerances § 180.1016 Ethylene; exemption from the requirement of a tolerance. Ethylene is...

  1. 40 CFR 180.1258 - Acetic acid; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Acetic acid; exemption from the... Exemptions From Tolerances § 180.1258 Acetic acid; exemption from the requirement of a tolerance. An... acetic acid when used as a preservative on post-harvest agricultural commodities intended for animal feed...

  2. 75 FR 35515 - Commercial Driver's License (CDL) Standards: Granting of Exemption; Volvo Trucks North America

    Science.gov (United States)

    2010-06-22

    ... Exemption; Volvo Trucks North America AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT... decision to grant Volvo Trucks North America, Inc.'s (Volvo) application for exemption to enable one of its... license (CDL) issued by one of the States. Volvo asserts that the exemption is necessary to support a...

  3. 75 FR 40765 - Hours of Service; Limited Exemption for the Distribution of Anhydrous Ammonia in Agricultural...

    Science.gov (United States)

    2010-07-14

    ... Federal Motor Carrier Safety Administration 49 CFR Part 395 Hours of Service; Limited Exemption for the... its proposal to grant a 2-year, limited exemption from the Federal hours-of-service regulations for... takes place within a 100 air-mile radius of the retail or wholesale distribution point. This exemption...

  4. 40 CFR 180.1162 - Acrylate polymers and copolymers; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Acrylate polymers and copolymers... RESIDUES IN FOOD Exemptions From Tolerances § 180.1162 Acrylate polymers and copolymers; exemption from the requirement of a tolerance. (a) Acrylate polymers and copolymers are exempt from the requirement of a...

  5. 16 CFR 1500.81 - Exemptions for food, drugs, cosmetics, and fuels.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Exemptions for food, drugs, cosmetics, and... § 1500.81 Exemptions for food, drugs, cosmetics, and fuels. (a) Food, drugs, and cosmetics. Substances subject to the Federal Food, Drug, and Cosmetic Act are exempted by section 2(f)(2) of the act; but where...

  6. 40 CFR 180.1282 - Bacillus firmus I-1582; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus firmus I-1582; exemption from... FOOD Exemptions From Tolerances § 180.1282 Bacillus firmus I-1582; exemption from the requirement of a..., for residues of Bacillus firmus I-1582 when used as a soil application or seed treatment. ...

  7. 29 CFR 779.388 - Exemption provided for food or beverage service employees.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Exemption provided for food or beverage service employees... Service Establishments Restaurants and Establishments Providing Food and Beverage Service § 779.388 Exemption provided for food or beverage service employees. (a) A special exemption is provided in section 13...

  8. 29 CFR 1602.35 - Political jurisdiction's exemption from reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Political jurisdiction's exemption from reporting... Local Government Information Report § 1602.35 Political jurisdiction's exemption from reporting... political jurisdiction may apply to the Commission for an exemption from the requirements set forth in this...

  9. 26 CFR 53.4958-2 - Definition of applicable tax-exempt organization.

    Science.gov (United States)

    2010-04-01

    ... Taxes § 53.4958-2 Definition of applicable tax-exempt organization. (a) Organizations described in... (the lookback period). (2) Exceptions from definition of applicable tax-exempt organization—(i) Private... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Definition of applicable tax-exempt...

  10. 26 CFR 1.923-1T - Temporary regulations; exempt foreign trade income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Temporary regulations; exempt foreign trade... Temporary regulations; exempt foreign trade income. (a) Foreign trade income. Foreign trade income of a FSC... for illustrations of the computation of a FSC's foreign trade income, exempt foreign trade income and...

  11. 40 CFR 166.50 - Reporting and recordkeeping requirements for crisis exemption.

    Science.gov (United States)

    2010-07-01

    ... requirements for crisis exemption. 166.50 Section 166.50 Protection of Environment ENVIRONMENTAL PROTECTION... EMERGENCY CONDITIONS Crisis Exemptions § 166.50 Reporting and recordkeeping requirements for crisis... a crisis exemption must be immediately reported to the Agency. (b) Final reports. (1) A report...

  12. 40 CFR 180.1240 - Thymol; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Thymol; exemption from the requirement... From Tolerances § 180.1240 Thymol; exemption from the requirement of a tolerance. (a) Time-limited exemptions from the requirement of a tolerance are established for residues of thymol on honey and honeycomb...

  13. 75 FR 38147 - FirstEnergy Nuclear Operating Company; Davis-Besse Nuclear Power Station; Exemption

    Science.gov (United States)

    2010-07-01

    ... COMMISSION FirstEnergy Nuclear Operating Company; Davis-Besse Nuclear Power Station; Exemption 1.0 Background... No. NFP-3, which authorizes operation of the Davis-Besse Nuclear Power Station, Unit 1 (DBNPS). The... regulations. Therefore, the exemption is authorized by law. Davis-Besse Nuclear Power Station Exemption...

  14. 40 CFR 180.1022 - Iodine-detergent complex; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Iodine-detergent complex; exemption... FOOD Exemptions From Tolerances § 180.1022 Iodine-detergent complex; exemption from the requirement of a tolerance. The aqueous solution of hydriodic acid and elemental iodine, including one or both of...

  15. 49 CFR 525.11 - Termination of exemption; amendment of alternative average fuel economy standard.

    Science.gov (United States)

    2010-10-01

    ... average fuel economy standard. 525.11 Section 525.11 Transportation Other Regulations Relating to... EXEMPTIONS FROM AVERAGE FUEL ECONOMY STANDARDS § 525.11 Termination of exemption; amendment of alternative average fuel economy standard. (a) Any exemption granted under this part for an affected model year does...

  16. 40 CFR 180.1202 - Bacillus sphaericus; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus sphaericus; exemption from... FOOD Exemptions From Tolerances § 180.1202 Bacillus sphaericus; exemption from the requirement of a... pesticides, Bacillus sphaericus when used in or on all food crops. ...

  17. 40 CFR 180.1128 - Bacillus subtilis MBI 600; exemption from the requirement of a tolerance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Bacillus subtilis MBI 600; exemption... FOOD Exemptions From Tolerances § 180.1128 Bacillus subtilis MBI 600; exemption from the requirement of... biofungicide Bacillus subtilis MBI 600 in or on all food commodities, including residues resulting from post...

  18. 41 CFR 109-38.204-4 - Report of exempted motor vehicles.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Report of exempted motor..., TRANSPORTATION, AND MOTOR VEHICLES 38-MOTOR EQUIPMENT MANAGEMENT 38.2-Registration, Identification, and Exemptions § 109-38.204-4 Report of exempted motor vehicles. DOE offices shall provide upon request the...

  19. 77 FR 26550 - Notice of Need To File Updated Information for Some Closed Captioning Exemption Petitions

    Science.gov (United States)

    2012-05-04

    ... Portable Document Format (PDF) at: http://www.fcc.gov/encyclopedia/economically-burdensome-exemption-closed... interested in continuing to request a closed captioning exemption for its programming must include up-to-date... captioning on the specific programming for which an exemption is sought. Specifically, each petition should...

  20. 40 CFR 52.2237 - NOX RACT and NOX conformity exemption.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false NOX RACT and NOX conformity exemption... RACT and NOX conformity exemption. Approval. EPA is approving the section 182(f) oxides of nitrogen (NOX) reasonably available control technology (RACT) and NOX conformity exemption request submitted by...