Sample records for exchanger slc4a8 mediates

  1. Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators.

    Directory of Open Access Journals (Sweden)

    Yumiko Kurokawa


    Full Text Available In the fission yeast Schizosaccharomyces pombe, genetic evidence suggests that two mediators, Rad22 (the S. pombe Rad52 homolog and the Swi5-Sfr1 complex, participate in a common pathway of Rhp51 (the S. pombe Rad51 homolog-mediated homologous recombination (HR and HR repair. Here, we have demonstrated an in vitro reconstitution of the central step of DNA strand exchange during HR. Our system consists entirely of homogeneously purified proteins, including Rhp51, the two mediators, and replication protein A (RPA, which reflects genetic requirements in vivo. Using this system, we present the first robust biochemical evidence that concerted action of the two mediators directs the loading of Rhp51 onto single-stranded DNA (ssDNA precoated with RPA. Dissection of the reaction reveals that Rad22 overcomes the inhibitory effect of RPA on Rhp51-Swi5-Sfr1-mediated strand exchange. In addition, Rad22 negates the requirement for a strict order of protein addition to the in vitro system. However, despite the presence of Rad22, Swi5-Sfr1 is still essential for strand exchange. Importantly, Rhp51, but neither Rad22 nor the Swi5-Sfr1 mediator, is the factor that displaces RPA from ssDNA. Swi5-Sfr1 stabilizes Rhp51-ssDNA filaments in an ATP-dependent manner, and this stabilization is correlated with activation of Rhp51 for the strand exchange reaction. Rad22 alone cannot activate the Rhp51 presynaptic filament. AMP-PNP, a nonhydrolyzable ATP analog, induces a similar stabilization of Rhp51, but this stabilization is independent of Swi5-Sfr1. However, hydrolysis of ATP is required for processive strand transfer, which results in the formation of a long heteroduplex. Our in vitro reconstitution system has revealed that the two mediators have indispensable, but distinct, roles for mediating Rhp51 loading onto RPA-precoated ssDNA.

  2. Perceived Organizational Support as a Mediator between Relational Exchange and Organizational Identification (United States)

    Sluss, David M.; Klimchak, Malayka; Holmes, Jeanne J.


    Using cross-level data from 364 supervisor-subordinate dyads, we examined how relational exchange quality, perceived organizational support (POS), and organizational identification interrelate. We found subordinate POS mediates the relationship between leader-member exchange (i.e., LMX) and organizational identification. We also found the…

  3. The mediating role of job satisfaction between leader-member exchange and turnover intentions. (United States)

    Han, Guohong Helen; Jekel, Marc


    The aim of the present study was to investigate whether job satisfaction mediates between leader-member exchange and nurse turnover intentions. Limited knowledge is available on the mediating role of job satisfaction between leader-member exchange and turnover intentions in the nursing field. This is a cross-sectional survey study. Data were collected in a US hospital. Higher leader-member exchange was associated with lower turnover intentions (β=-0.41, Pmember exchange was positively related to one's job satisfaction (β=0.50, Pmember exchange and job satisfaction were both controlled for, the link between leader-member exchange and turnover intentions was no longer significant (β=-0.12, P>0.05). Job satisfaction mediates the link between leader-member exchange and turnover intentions. The present study reinforces the significant role of managers. Nurse managers can try to cultivate a good relationship with the nurses. This can enhance nurses' job satisfaction and in turn lower their turnover intentions. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

  4. Frictional drag between quantum wells mediated by phonon exchange

    DEFF Research Database (Denmark)

    Bønsager, M.C.; Flensberg, Karsten; Hu, Ben Yu-Kuang


    lattice imperfections or electronic excitations is accounted for. In the case of GaAs quantum wells, we find that for a phonon mean free path l(ph) smaller than a critical value, imperfection scattering dominates and the drag rate varies as ln(l(ph)/d) over many orders of magnitude of the layer separation......We use the Kubo formalism to evaluate the contribution of acoustic-phonon exchange to the frictional drag between nearby two-dimensional electron systems. In the case of free phonons, we find a divergent drag rate (tau(D)(-l)). However, tau(D)(-l) becomes finite when phonon scattering from either...

  5. Justice, leader-member exchange, and job performance: are their relationships mediated by organizational culture? (United States)

    Tziner, Aharon; Shultz, Tamar; Fisher, Tom


    The hypothesis that organizational justice is linked to leader-member exchange, which in turn affects job performance, was examined. It was predicted that two dimensions of organizational culture, employee supportiveness and attention to detail, would affect both leader-member exchange and organizational justice. Results from a sample of 75 employees of a public service organization found solid support for the predicted model. Contrary to expectations, however, the two aspects of organizational culture were found to play a mediating role: they were affected by organizational justice and in turn affected leader-member exchange. The theoretical implications of the results are discussed.

  6. Leader-member exchange and safety citizenship behavior: The mediating role of coworker trust. (United States)

    Jiang, Li; Li, Feng; Li, YongJuan; Li, Rui


    To achieve high safety levels, mere compliance with safety regulations is not sufficient; employees must be proactive and demonstrate safety citizenship behaviors. Trust is considered as a mechanism for facilitating the effects of a leader on employee citizenship behaviors. Increasingly research has focused on the role of trust in a safety context; however, the role of coworker trust has been overlooked. The mediating role of coworker trust in the relationship between the leader-member exchange and safety citizenship behavior is the focus of this field study. Front-line employees from an air traffic control center and an airline maintenance department completed surveys measuring leader-member exchange, co-worker trust, and safety citizenship behavior. Structural Equation Modeling revealed affective and cognitive trust in coworkers is influenced by leader-member exchange. A trust-based mediation model where cognitive trust and affective trust mediate the relationship between the leader-member exchange and safety citizenship behavior emerged. Results of this study add to our understanding of the relationship between leader-member exchange and safety behavior. The effect of co-worker trust and the extent to which employees participate in workplace safety practice were identified as critical factors. The findings show that managers need to focus on developing cognitive and affective coworker trust to improve safety citizenship behaviors.

  7. The Role of Modular Robotics in Mediating Nonverbal Social Exchanges

    DEFF Research Database (Denmark)

    Marti, P; Giusti, L; Lund, Henrik Hautop


    This paper outlines the use of modular robotics to encourage and facilitate nonverbal communication during therapeutic intervention in dementia care. A set of new socially interactive modular robotic devices called rolling pins (RPs) has been designed and developed to assist the therapist...... is that they are able to communicate with each other or with other devices equipped with the same radio communication technology. The RPs are usually used in pairs, as the local feedback of an RP can be set depending not only on its own speed and orientation but also on the speed and the orientation of the peer RP....... The system is not used as a therapeutic tool per se but as a facilitator and a mediator of social dynamics during normal therapy to counteract social isolation that can result in dementia through the loss of social skills. An experiment is reported that shows that by using the RPs, the patients participated...

  8. Leader-member exchange, organizational identification and the mediating role of job involvement for nurses. (United States)

    Katrinli, Alev; Atabay, Gulem; Gunay, Gonca; Guneri, Burcu


    This paper is a report of a study to explore the relationship between leader-member exchange quality and organizational identification and the mediating role of job involvement in this relationship. As a result of the fast-changing structures and increasing competition, healthcare organizations increasingly demand highly qualified nurses who also have positive work attitudes towards the job and the organization. Among these positive work attitudes, organizational identification affects nurses' job performance and, in turn, the quality of care and patient satisfaction. The quality of the relationship between nurse supervisors and nurses, which is examined in the leader-member exchange context, can be an important determinant for organizational identification. This relationship is also affected by nurses' job involvement. The sample consisted of 148 nurses working in a private general hospital. Questionnaires, which included measures for organizational identification, level of leader-member exchange quality, job involvement and questions about the demographic characteristics of the sample, were distributed in 2007. The response rate was 87%. A statistically significant and positive relationship was found between leader-member exchange quality and organizational identification. The results also reveal that job involvement mediates the positive effects of leader-member exchange quality on organizational identification. If nurse supervisors increase their awareness of the effects of their behaviours towards their nurses, they can increase the nurses' performance and achieve desired results through increasing job involvement and organizational identification.

  9. The Relationship between Psychological Contract Breach and Organizational Commitment: Exchange Imbalance as a Moderator of the Mediating Role of Violation (United States)

    Cassar, Vincent; Briner, Rob B.


    This study tested the mediating role of violation in the relationship between breach and both affective and continuance commitment and the extent to which this mediating role is moderated by exchange imbalance amongst a sample of 103 sales personnel. Results suggest that violation mediated the relationship between breach and commitment. Also,…

  10. Role stressors and job attitudes: a mediated model of leader-member exchange. (United States)

    Zhang, Rui-Ping; Tsingan, Li; Zhang, Long-Ping


    Workers with high levels of role stressors have been known to report low job satisfaction and high turnover intention. However, how the role stressors-job attitudes relationship is influenced by leader-member exchange has hardly been studied. This study examined the effect of leader-member exchange (leader support) on the relationship between chronic role stressors (i.e., role ambiguity and role conflict) and job attitudes (i.e., job satisfaction and turnover intention). Employees (N = 162) who enrolled in weekend psychology courses were investigated. The results showed that leader-member exchange mediated the effects of role stressors on job satisfaction and turnover intention. Implications of these results are discussed and directions for future research are suggested.

  11. Supervisors' upward exchange relationships and subordinate outcomes: testing the multilevel mediation role of empowerment. (United States)

    Zhou, Le; Wang, Mo; Chen, Gilad; Shi, Junqi


    This study empirically examined the proposition that supervisors' exchange relationships with their own supervisors (i.e., leader-leader exchange, or LLX) are related to their subordinates' work-related outcomes through 3 mechanisms: (a) leaders modeling their LLX to develop and maintain their exchange relationships with their subordinates (i.e., leader-member exchange, or LMX), (b) motivating the team and its members, captured by team and individual empowerment, and (c) facilitating the relationships between LMX and individual outcomes. Analyses of multisource and lagged data from 104 team supervisors and 577 subordinates showed that LMX mediated the positive relationship of LLX on subordinates' individual empowerment. Furthermore, team empowerment and individual empowerment sequentially mediated the positive relationships between LLX and subordinates' job satisfaction and job performance. The authors also found that the indirect relationships of LMX with job satisfaction and job performance via individual empowerment were stronger when LLX was higher. Theoretical and practical implications of these findings are discussed. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  12. HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1. (United States)

    Narayan, Kedar; Su, Katherine W; Chou, Chih-Ling; Khoruzhenko, Stanislav; Sadegh-Nasseri, Scheherazade


    The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II molecules within antigen presenting cells by generating a "peptide-receptive" MHC class II conformation (MHC(receptive)) to which peptides readily bind and rapidly unbind. While recent work has uncovered the determinants of DM recognition and effector functions, the nature of MHC(receptive) and its interaction with DM remains unclear. Here, we show that DM induces but does not stabilize MHC(receptive) in the absence of peptides. We demonstrate that DM is out-competed by certain superantigens, and increasing solvent viscosity inhibits DM-induced peptide association. We suggest that DM mediates peptide exchange by interacting transiently and repeatedly with MHC class II molecules, continually generating MHC(receptive). The simultaneous presence of peptide and DM in the milieu is thus crucial for the efficient generation of specific peptide-MHC class II complexes over time.

  13. Stimulation of Dmc1-mediated DNA strand exchange by the human Rad54B protein (United States)

    Sarai, Naoyuki; Kagawa, Wataru; Kinebuchi, Takashi; Kagawa, Ako; Tanaka, Kozo; Miyagawa, Kiyoshi; Ikawa, Shukuko; Shibata, Takehiko; Kurumizaka, Hitoshi; Yokoyama, Shigeyuki


    The process of homologous recombination is indispensable for both meiotic and mitotic cell division, and is one of the major pathways for double-strand break (DSB) repair. The human Rad54B protein, which belongs to the SWI2/SNF2 protein family, plays a role in homologous recombination, and may function with the Dmc1 recombinase, a meiosis-specific Rad51 homolog. In the present study, we found that Rad54B enhanced the DNA strand-exchange activity of Dmc1 by stabilizing the Dmc1–single-stranded DNA (ssDNA) complex. Therefore, Rad54B may stimulate the Dmc1-mediated DNA strand exchange by stabilizing the nucleoprotein filament, which is formed on the ssDNA tails produced at DSB sites during homologous recombination. PMID:16945962

  14. Towards hot electron mediated charge exchange in hyperthermal energy ion-surface interactions

    DEFF Research Database (Denmark)

    Ray, M. P.; Lake, R. E.; Thomsen, Lasse Bjørchmar


    We have made Na + and He + ions incident on the surface of solid state tunnel junctions and measured the energy loss due to atomic displacement and electronic excitations. Each tunnel junction consists of an ultrathin film metal–oxide–semiconductor device which can be biased to create a band of hot...... shows that the primary energy loss mechanism is the atomic displacement of Au atoms in the thin film of the metal–oxide–semiconductor device. We propose that neutral particle detection of the scattered flux from a biased device could be a route to hot electron mediated charge exchange....

  15. Oceanic Uptake of Oxygen During Deep Convection Events Through Diffusive and Bubble-Mediated Gas Exchange (United States)

    Sun, Daoxun; Ito, Takamitsu; Bracco, Annalisa


    The concentration of dissolved oxygen (O2) plays fundamental roles in diverse chemical and biological processes throughout the oceans. The balance between the physical supply and the biological consumption controls the O2 level of the interior ocean, and the O2 supply to the deep waters can only occur through deep convection in the polar oceans. We develop a theoretical framework describing the oceanic O2 uptake during open-ocean deep convection events and test it against a suite of numerical sensitivity experiments. Our framework allows for two predictions, confirmed by the numerical simulations. First, both the duration and the intensity of the wintertime cooling contribute to the total O2 uptake for a given buoyancy loss. Stronger cooling leads to deeper convection and the oxygenation can reach down to deeper depths. Longer duration of the cooling period increases the total amount of O2 uptake over the convective season. Second, the bubble-mediated influx of O2 tends to weaken the diffusive influx by shifting the air-sea disequilibrium of O2 toward supersaturation. The degree of compensation between the diffusive and bubble-mediated gas exchange depends on the dimensionless number measuring the relative strength of oceanic vertical mixing and the gas transfer velocity. Strong convective mixing, which may occur under strong cooling, reduces the degree of compensation so that the two components of gas exchange together drive exceptionally strong oceanic O2 uptake.

  16. Nuclear overhauser enhancement mediated chemical exchange saturation transfer imaging at 7 Tesla in glioblastoma patients.

    Directory of Open Access Journals (Sweden)

    Daniel Paech

    Full Text Available BACKGROUND AND PURPOSE: Nuclear Overhauser Enhancement (NOE mediated chemical exchange saturation transfer (CEST is a novel magnetic resonance imaging (MRI technique on the basis of saturation transfer between exchanging protons of tissue proteins and bulk water. The purpose of this study was to evaluate and compare the information provided by three dimensional NOE mediated CEST at 7 Tesla (7T and standard MRI in glioblastoma patients. PATIENTS AND METHODS: Twelve patients with newly diagnosed histologically proven glioblastoma were enrolled in this prospective ethics committee-approved study. NOE mediated CEST contrast was acquired with a modified three-dimensional gradient-echo sequence and asymmetry analysis was conducted at 3.3 ppm (B1 = 0.7 µT to calculate the magnetization transfer ratio asymmetry (MTR(asym. Contrast enhanced T1 (CE-T1 and T2-weighted images were acquired at 3T and used for data co-registration and comparison. RESULTS: Mean NOE mediated CEST signal based on MTR(asym values over all patients was significantly increased (p<0.001 in CE-T1 tumor (-1.99 ± 1.22%, tumor necrosis (-1.36 ± 1.30% and peritumoral CEST hyperintensities (PTCH within T2 edema margins (-3.56 ± 1.24% compared to contralateral normal appearing white matter (-8.38 ± 1.19%. In CE-T1 tumor (p = 0.015 and tumor necrosis (p<0.001 mean MTR(asym values were significantly higher than in PTCH. Extent of the surrounding tumor hyperintensity was smaller in eight out of 12 patients on CEST than on T2-weighted images, while four displayed at equal size. In all patients, isolated high intensity regions (0.40 ± 2.21% displayed on CEST within the CE-T1 tumor that were not discernible on CE-T1 or T2-weighted images. CONCLUSION: NOE mediated CEST Imaging at 7 T provides additional information on the structure of peritumoral hyperintensities in glioblastoma and displays isolated high intensity regions within the CE-T1 tumor that cannot be acquired on CE-T1 or T2

  17. The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin

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    Fluharty Eric


    Full Text Available Abstract Background Phospholipase D (PLD is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF family of GTPases, but the mechanism of activation of PLD and ARF by extracellular signals has not been fully established. Here we tested the hypothesis that ARF-guanine nucleotide exchange factors (ARF-GEFs of the cytohesin/ARNO family mediate the activation of ARF and PLD by insulin. Results Wild type ARNO transiently transfected in HIRcB cells was translocated to the plasma membrane in an insulin-dependent manner and promoted the translocation of ARF to the membranes. ARNO mutants: ΔCC-ARNO and CC-ARNO were partially translocated to the membranes while ΔPH-ARNO and PH-ARNO could not be translocated to the membranes. Sec7 domain mutants of ARNO did not facilitate the ARF translocation. Overexpression of wild type ARNO significantly increased insulin-stimulated PLD activity, and mutations in the Sec7 and PH domains, or deletion of the PH or CC domains inhibited the effects of insulin. Conclusions Small ARF-GEFs of the cytohesin/ARNO family mediate the activation of ARF and PLD by the insulin receptor.

  18. The Relationship between Information Exchange Benefits and Performance: the Mediating Effect of Supply Chain Compliance in the Chinese Poultry Chain

    NARCIS (Netherlands)

    Peng, G.; Trienekens, J.H.; Omta, S.W.F.; Wang, W.


    This paper aims to examine the relationships between information exchange benefits and company performance, and the mediating effect of supply chain compliance on this relationship. A sample of 165 buying companies and of 96 suppliers were analyzed by partial least square (PLS) path modeling. Five

  19. Leader–member exchange fosters work engagement: The mediating role of job crafting

    Directory of Open Access Journals (Sweden)

    Mirjam Radstaak


    Full Text Available Orientation: The right balance between job demands and job resources are essential for employees to bring energy and enthusiasm to work. Employees who experience high-quality relationships with their supervisors may actively craft their job demands and job resources and feel more engaged.Research purpose: The current study examined the associations between leader–member exchange (LMX, job crafting and work engagement. Motivation: This study attempts to gain more insight in the associations between LMX, job crafting and work engagement. It was hypothesised that high-quality relationships with supervisors fosters work engagement because it stimulates employees to craft their jobs by increasing social and structural job resources and challenging job demands and by decreasing hindering job demands.Research approach, design and methodology: Participants (N = 402 working for a leading mail and parcels company in the Netherlands completed questionnaires measuring LMX, work engagement and job crafting. Structural equation modelling was used to examine the hypotheses.Main findings: Increasing social job resources (β = 0.01, SE = 0.00, p < 0.001 and increasing challenging job demands (β = 0.08, SE = 0.04, p < 0.05 were significant mediators in the association between LMX and work engagement. Increasing structural job resources (β = 0.00, SE = 0.00, p = 0.92 and decreasing hindering job demands (β = -0.00, SE 0.00, p = 0.09 were not significant mediators.Practical and managerial implications: Supervisors who are capable of building high-quality relationships with their employees based on trust, respect and loyalty will foster a positive, fulfilling work-related state of mind among employees because they are more willing to proactively craft a challenging and resourceful work environment.Contribution or value-add: The findings of this study showed the importance of high-quality relationships with supervisors and were unique in examining the

  20. Reduction of molecular gas diffusion through gaskets in leaf gas exchange cuvettes by leaf‐mediated pores

    DEFF Research Database (Denmark)

    Boesgaard, Kristine Stove; Mikkelsen, Teis Nørgaard; Ro‐Poulsen, Helge


    There is an ongoing debate on how to correct leaf gas exchange measurements for the unavoidable diffusion leakage that occurs when measurements are done in non‐ambient CO2 concentrations. In this study, we present a theory on how the CO2 diffusion gradient over the gasket is affected by leaf......‐mediated pores (LMP) and how LMP reduce diffusive exchange across the gaskets. Recent discussions have so far neglected the processes in the quasi‐laminar boundary layer around the gasket. Counter intuitively, LMP reduce the leakage through gaskets, which can be explained by assuming that the boundary layer...

  1. Mediated cross-cultural learning through exchange in higher agricultural education

    NARCIS (Netherlands)

    Wals, A.E.J.; Sriskandarajah, N.


    This article reports on the long-term impact of an intensive European Union-Australia student exchange programme that took place in 2004 and 2005. The programme, Learning through Exchange about Agriculture, Food Systems and Environment (LEAFSE), was designed to facilitate exchange of post-graduate

  2. Analisa Pengaruh Leader-member Exchange Terhadap Turnover Intention Dengan Kepuasan Kerja Sebagai Variable Mediator Di Restoran “X” Surabaya


    Valensia, Monica; Kusumo, Marcella; Kartika, Endo Wijaya; Nugroho, Agustinus


    Penelitian ini ditunjukan untuk menguji Analisa Pengaruh Leader-member Exchange Terhadap Turnover Intention Dengan Kepuasan Kerja Sebagai Variabel Mediator di Restoran “X” Surabaya.Uji hipotesis dilakukan dengan menguji dua model guna mengetahui apakah Leader-member Exchange berpengaruh positif signifikan terhadap kepuasan kerja, apakah kepuasan kerja berpengaruh negatif signifikan terhadap turnover intention, dan apakah Leader-member Exchange berpengaruh negatif signifikan terhadap turnover ...

  3. Abusive Supervision by Academic Supervisors and Postgraduate Research Students' Creativity: The Mediating Role of Leader-Member Exchange and Intrinsic Motivation (United States)

    Meng, Yi; Tan, Jing; Li, Jing


    Drawing upon the componential theory of creativity, cognitive evaluation theory and social exchange theory, the study reported in this paper tested a mediating model based on the hypothesis that abusive supervision negatively influences creativity sequentially through leader-member exchange (LMX) and intrinsic motivation. The study employed…

  4. Neutrinoless ββ decay mediated by the exchange of light and heavy neutrinos: the role of nuclear structure correlations (United States)

    Menéndez, J.


    Neutrinoless β β decay nuclear matrix elements calculated with the shell model and energy-density functional theory typically disagree by more than a factor of two in the standard scenario of light-neutrino exchange. In contrast, for a decay mediated by sterile heavy neutrinos the deviations are reduced to about 50%, an uncertainty similar to the one due to short-range effects. We compare matrix elements in the light- and heavy-neutrino-exchange channels, exploring the radial, momentum transfer and angular momentum-parity matrix element distributions, and considering transitions that involve correlated and uncorrelated nuclear states. We argue that the shorter-range heavy-neutrino exchange is less sensitive to collective nuclear correlations, and that discrepancies in matrix elements are mostly due to the treatment of long-range correlations in many-body calculations. Our analysis supports previous studies suggesting that isoscalar pairing correlations, which affect mostly the longer-range part of the neutrinoless β β decay operator, are partially responsible for the differences between nuclear matrix elements in the standard light-neutrino-exchange mechanism.

  5. Differences in Electronic Exchanges in Synchronous and Asynchronous Computer-Mediated Communication: The Effect of Culture as a Mediating Variable (United States)

    Angeli, Charoula; Schwartz, Neil H.


    Two hundred and eighty undergraduates from universities in two countries were asked to read didactic material, and then think and write about potential solutions to an ill-defined problem. The writing was conducted within a synchronous or asynchronous computer-mediated communication (CMC) environment. Asynchronous CMC took the form of email…

  6. Servant Leadership, Organisational Citizenship Behavior and Creativity: The Mediating Role of Team-Member Exchange

    Directory of Open Access Journals (Sweden)

    Winifrida Malingumu


    Full Text Available Using a multi-source field study design with 184 unique triads of employees-supervisor dyads, this paper examines whether servant leaders install a serving attitude among employees. That is, servant leaders aim to encourage employees to take responsibility, to cooperate and to create high quality interactions with each other (team-member exchange; TMX. We hypothesise that servant leadership will have an influence on Organisational Citizenship Behavior (OCB and creativity through team-member exchange. Two facets of OCB are distinguished: organisational citizenship behaviour towards individuals (OCBI, on the one hand, and taking up extra tasks that benefit the organisation (OCBO, on the other hand. The results show that servant leadership is positively related to team-member exchange, and that team-member exchange is positively related to OCBI, OCBO and creativity. The bootstrapping estimates indicated significant indirect effects of servant leadership on the three target variables through team-member exchange. The study’s findings add to the body of literature on servant leadership, OCB and creativity at the workplace, and underline the importance of creating favourable working conditions that foster positive and high quality team-member exchange. This study also broadens our understanding on the importance of co-workers on the relation between servant leadership and organizational citizenship behavior (OCB and creativity.

  7. Mediated effects of physical risk factors, leader-member exchange and empowerment in predicting perceived injury risk. (United States)

    Muldoon, Jeffery; Matthews, Russell A; Foley, Caroline


    In the context of conservation of resources theory, we examine the indirect (mediated) effects of physical risk factors, leader-member exchange (LMX) and empowerment on perceived injury risk in a heterogeneous sample (N = 226) of individuals employed in occupations related to production, construction and installation/maintenance. Positioning work role stressors and upward safety communications as two important mediating variables, as predicted, LMX and empowerment demonstrated significant indirect effects on perceived injury risk. Results from our model also provide preliminary evidence that an asymmetrical dualistic process exists in terms of the effect physical risk factors have on perceived injury risk via depletion of both psychological (i.e. role stressors) and physical resources (i.e. physical symptoms). Theoretical and practical implications based on the results of our model are also discussed. Copyright © 2011 John Wiley & Sons, Ltd.

  8. Idiosyncratic deals and employee outcomes: the mediating roles of social exchange and self-enhancement and the moderating role of individualism. (United States)

    Liu, Jun; Lee, Cynthia; Hui, Chun; Kwan, Ho Kwong; Wu, Long-Zeng


    The majority of studies on idiosyncratic employment arrangements ("i-deals") are based on social exchange theory. The authors suggest that self-enhancement theory, in addition to social exchange, can be used to explain the effects of i-deals. Using a multisource sample including 230 employees and 102 supervisors from 2 Chinese companies, the authors adopt a 3-wave lagged design to examine the mediating roles of social exchange and self-enhancement and the moderating role of individualism in the relationships between i-deals and employee outcomes, as indicated by proactive behaviors and affective commitment. The results of bootstrapping analyses confirm the mediating effects of social exchange and self-enhancement. In addition, employees with high levels of individualism are more receptive to self-enhancement effects; in contrast, employees with low levels of individualism are more receptive to social exchange effects. PsycINFO Database Record (c) 2013 APA, all rights reserved

  9. Reducing employees’ turnover intention through Hr-induced organizational citizenship behaviour: Leader-member exchange as the mediator

    Directory of Open Access Journals (Sweden)



    Full Text Available This study examines the possibility of inducing organizational citizenship behavior (OCB through human resource (HR philosophy and high involvement HR practices administered at the workplace. Leader-member exchange (LMX, a basis of relational infrastructure, is posited to be a potential mediator. Data was collected from hotel frontline employees, tested and analyzed through structural equation modeling. Findings show that HR philosophy drives the formulation of the bundles of high involvement human resource practices and such philosophy contribute to employees’ willingness in exhibiting organizational citizenship behavior (OCB directed at individuals (OCBI as well as organizations (OCBO as a whole. High involvement HR practices, however, do not elicit OCB but these practices are significantly related to LMX, a new theoretical insight which should invite future research. Although exchanges between supervisors and subordinates are shown to have influences on employees’ willingness in performing OCB, LMX does not, however, mediate the relationship between high involvement HR practices and OCB. Overall, hotel frontline employees participated in this study exhibit more OCBO, rather than OCBI; and such behavior reduce their intention to leave. Both theoretical and practical implications as well as avenues for future research are discussed.

  10. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles

    Energy Technology Data Exchange (ETDEWEB)

    Meier, P.J.; Knickelbein, R.; Moseley, R.H.; Dobbins, J.W.; Boyer, J.L.


    To determine whether anion exchangers might play a role in hepatic bile formation, the authors looked for the presence of Cl/sup -/:OH/sup -/ and Cl/sup -/:HCO3/sup -/ exchange in highly purified canalicular (c) and basolateral (bl) rat liver plasma membrane (LPM) vesicles. In cLPM vesicles, a pH gradient stimulated /sup 36/Cl- uptake twofold above values obtained during pH-equilibrated conditions. When 50 mM HCO3/sup -/ was also present inside the vesicles, the same pH gradient resulted in Cl/sup -/ uptake to levels fourfold above pH- and HCO3--equilibrated controls and two- to threefold above Cl- equilibrium. Initial rates of both pH and HCO3/sup -/ gradient-stimulated Cl/sup -/ uptake were completely inhibited by 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS). A valinomycin-induced K/sup +/ diffusion potential (inside positive) also stimulated Cl/sup -/ uptake in cLPM, but this conductive Cl- pathway was insensitive to DIDS. The DIDS-sensitive, pH and HCO3- gradient-stimulated Cl/sup -/ uptake demonstrated: saturation with Cl/sup -/; partial inhibition by bumetanide (26%), furosemide (33%), probenecid (37%), and 4-acetamido-4'-isothiocyano-2,2'-disulfonic acid stilbene (49%); cis-inhibition by chloride and nitrate but not by sulfate and various organic anions, and independence from the membrane potential. These data demonstrate the presence of an electroneutral Cl/sup -/:OH/sup -/ and Cl/sup -/:HCO3/sup -/ exchanger in rat liver canalicular membranes that favors Cl/sup -/:HCO3/sup -/ exchange. In contrast, no evidence was found for the presence of a Cl/sup -/:HCO3/sup -/ (OH/sup -/) exchange system in blLPM vesicles.

  11. Sensitivity Enhancement by Exchange Mediated MagnetizationTransfer of the Xenon Biosensor Signal

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, Sandra; Chavez, Lana; Lowery, Thomas J.; Han, Song-I.; Wemmer, David E.; Pines, Alexander


    Hyperpolarized xenon associated with ligand derivitized cryptophane-A cages has been developed as a NMR based biosensor. To optimize the detection sensitivity we describe use of xenon exchange between the caged and bulk dissolved xenon as an effective signal amplifier. This approach, somewhat analogous to 'remote detection' described recently, uses the chemical exchange to repeatedly transfer spectroscopic information from caged to bulk xenon, effectively integrating the caged signal. After an optimized integration period, the signal is read out by observation of the bulk magnetization. The spectrum of the caged xenon is reconstructed through use of a variable evolution period before transfer and Fourier analysis of the bulk signal as a function of the evolution time.

  12. Counterion-Mediated Ligand Exchange for PbS Colloidal Quantum Dot Superlattices. (United States)

    Balazs, Daniel M; Dirin, Dmitry N; Fang, Hong-Hua; Protesescu, Loredana; ten Brink, Gert H; Kooi, Bart J; Kovalenko, Maksym V; Loi, Maria Antonietta


    In the past years, halide capping became one of the most promising strategies to passivate the surface of colloidal quantum dots (CQDs) in thin films to be used for electronic and optoelectronic device fabrication. This is due to the convenient processing, strong n-type characteristics, and ambient stability of the devices. Here, we investigate the effect of three counterions (ammonium, methylammonium, and tetrabutylammonium) in iodide salts used for treating CQD thin films and shed light on the mechanism of the ligand exchange. We obtain two- and three-dimensional square-packed PbS CQD superlattices with epitaxial merging of nearest neighbor CQDs as a direct outcome of the ligand-exchange reaction and show that the order in the layer can be controlled by the nature of the counterion. Furthermore, we demonstrate that the acidity of the environment plays an important role in the substitution of the carboxylates by iodide ions at the surface of lead chalcogenide quantum dots. Tetrabutylammonium iodide shows lower reactivity compared to methylammonium and ammonium iodide due to the nonacidity of the cation, which eventually leads to higher order but also poorer carrier transport due to incomplete removal of the pristine ligands in the QD thin film. Finally, we show that single-step blade-coating and immersion in a ligand exchange solution such as the one containing methylammonium iodide can be used to fabricate well performing bottom-gate/bottom-contact PbS CQD field effect transistors with record subthreshold swing.

  13. Stimulation of Dmc1-mediated DNA strand exchange by the human Rad54B protein


    Sarai, Naoyuki; Kagawa, Wataru; Kinebuchi, Takashi; Kagawa, Ako; Tanaka, Kozo; Miyagawa, Kiyoshi; Ikawa, Shukuko; Shibata, Takehiko; Kurumizaka, Hitoshi; Yokoyama, Shigeyuki


    The process of homologous recombination is indispensable for both meiotic and mitotic cell division, and is one of the major pathways for double-strand break (DSB) repair. The human Rad54B protein, which belongs to the SWI2/SNF2 protein family, plays a role in homologous recombination, and may function with the Dmc1 recombinase, a meiosis-specific Rad51 homolog. In the present study, we found that Rad54B enhanced the DNA strand-exchange activity of Dmc1 by stabilizing the Dmc1–single-stranded...

  14. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. (United States)

    Tsumura, Maki; Sobhan, Ubaidus; Muramatsu, Takashi; Sato, Masaki; Ichikawa, Hideki; Sahara, Yoshinori; Tazaki, Masakazu; Shibukawa, Yoshiyuki


    Odontoblasts are involved in the transduction of stimuli applied to exposed dentin. Although expression of thermo/mechano/osmo-sensitive transient receptor potential (TRP) channels has been demonstrated, the properties of TRP vanilloid 1 (TRPV1)-mediated signaling remain to be clarified. We investigated physiological and pharmacological properties of TRPV1 and its functional coupling with cannabinoid (CB) receptors and Na(+)-Ca(2+) exchangers (NCXs) in odontoblasts. Anandamide (AEA), capsaicin (CAP), resiniferatoxin (RF) or low-pH evoked Ca(2+) influx. This influx was inhibited by capsazepine (CPZ). Delay in time-to-activation of TRPV1 channels was observed between application of AEA or CAP and increase in [Ca(2+)](i). In the absence of extracellular Ca(2+), however, an immediate increase in [Ca(2+)](i) was observed on administration of extracellular Ca(2+), followed by activation of TRPV1 channels. Intracellular application of CAP elicited inward current via opening of TRPV1 channels faster than extracellular application. With extracellular RF application, no time delay was observed in either increase in [Ca(2+)](i) or inward current, indicating that agonist binding sites are located on both extra- and intracellular domains. KB-R7943, an NCX inhibitor, yielded an increase in the decay time constant during TRPV1-mediated Ca(2+) entry. Increase in [Ca(2+)](i) by CB receptor agonist, 2-arachidonylglycerol, was inhibited by CB1 receptor antagonist or CPZ, as well as by adenylyl cyclase inhibitor. These results showed that TRPV1-mediated Ca(2+) entry functionally couples with CB1 receptor activation via cAMP signaling. Increased [Ca(2+)](i) by TRPV1 activation was extruded by NCXs. Taken together, this suggests that cAMP-mediated CB1-TRPV1 crosstalk and TRPV1-NCX coupling play an important role in driving cellular functions following transduction of external stimuli to odontoblasts. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. The RITHME inter-mediation platform for data exchanges between healthcare professionals. (United States)

    Beuscart, R; Beuscart-Zéphir, M C; Renard, J M; Delerue, D; Souf, A


    Data Exchanges between Healthcare Professionals are always limited to paper. For letters, reports, results, the physicians and hospitals are yet using the classical post-office mailing system. With the growing development of Medical Informatics within the Hospital Information Systems and the GPs offices, the way to exchange medical data will be more and more oriented towards the Telematics procedures. If Tele-consultation, video-conferencing applications appear as routine procedures, a safe, protected, and rapid transmission of medical data and records through electronic mailing systems is not yet really available. The Rithme Intermediation Platform is an experimental product, tested in the town of Armentières (in the City of Lille) in the North of France to allow a better, safer, more rapid electronic communication between all the professionals of a geographical sector. One of the mail component of this platform is the "Events Server" which collects and displays all the available information concerning a dedicated patient to the medical authorized correspondents. To realise this task the Rithme Platform takes charge of 4 main functions: formatting the messages, assuring the security, managing the directories, notifying emergencies. Currently experienced with success in the City of Lille, this Platform will be soon customised and commercialized.

  16. Surfactant-mediated ion exchange and charge reversal at ionic liquid interfaces. (United States)

    Chen, Lang G; Lerum, Ronald V; Aranda-Espinoza, Helim; Bermudez, Harry


    Room-temperature ionic liquids (ILs) exhibit a unique set of properties due to their charged character, presenting opportunities for numerous applications. Here, we show that the combination of charged surfactants with ILs leads to rich interfacial behavior due to the interplay between electrostatic and surface forces. Using traditional measures of surface activity and X-ray photoelectron spectroscopy (XPS), we find that sodium alkyl sulfates and alkyl trimethylammonium bromides are, indeed, surface-active at the air-IL interfaces of both [EMIM][EtSO(4)] and [BHEDMA][MeSO(3)]. XPS also reveals that surfactant counterions readily dissociate into the bulk, which when combined with the surfactant surface activity has striking consequences. We find that ion exchange occurs between surfactants and like-charged IL ions, with the greatest exchange for short surfactant alkyl chains. The initial negative surface charge of neat [EMIM][EtSO(4)] can be switched to positive by the addition of alkyl trimethylammonium bromides, with the effect most pronounced at short chain lengths. By contrast, the surface charge of [BHEDMA][MeSO(3)] is largely unaffected by the added surfactants, suggesting a key role for the strength of ion-pairing within the IL. The results here illustrate a simple but effective means of manipulating IL interfacial properties.

  17. Reduction of molecular gas diffusion through gaskets in leaf gas exchange cuvettes by leaf-mediated pores. (United States)

    Boesgaard, Kristine S; Mikkelsen, Teis N; Ro-Poulsen, Helge; Ibrom, Andreas


    There is an ongoing debate on how to correct leaf gas exchange measurements for the unavoidable diffusion leakage that occurs when measurements are done in non-ambient CO2 concentrations. In this study, we present a theory on how the CO2 diffusion gradient over the gasket is affected by leaf-mediated pores (LMP) and how LMP reduce diffusive exchange across the gaskets. Recent discussions have so far neglected the processes in the quasi-laminar boundary layer around the gasket. Counter intuitively, LMP reduce the leakage through gaskets, which can be explained by assuming that the boundary layer at the exterior of the cuvette is enriched with air from the inside of the cuvette. The effect can thus be reduced by reducing the boundary layer thickness. The theory clarifies conflicting results from earlier studies. We developed leaf adaptor frames that eliminate LMP during measurements on delicate plant material such as grass leaves with circular cross section, and the effectiveness is shown with respiration measurements on a harp of Deschampsia flexuosa leaves. We conclude that the best solution for measurements with portable photosynthesis systems is to avoid LMP rather than trying to correct for the effects. © 2013 John Wiley & Sons Ltd.

  18. Evidence for carrier-mediated Cl-SO/sub 4/ exchange in rabbit ileal basolateral membrane vesicles

    Energy Technology Data Exchange (ETDEWEB)

    Schron, C.M.; Knickelbein, R.G.; Aronson, P.S.; Dobbins, J.W.


    In rabbit ileal basolateral membrane (BLM) vesicles, an outwardly directed Cl gradient ((Cl) in/out = 60/6 mM) stimulated the initial velocity of /sup 35/SO/sub 4/ uptake compared with uptake in the absence of Cl. Under Cl gradient conditions, /sup 35/SO/sub 4/ was transiently accumulated at a concentration twice that found at equilibrium (overshoot). Chloride gradient-stimulated SO/sub 4/ uptake was markedly reduced by inhibitors of anion exchange and was saturable. SO/sub 4/ uptake by BLM vesicles was not stimulated by imposition of an inside-positive electrical potential, suggesting that the stimulation by a Cl gradient was not due to an induced electrical potential. Oxalate, nitrate, iodide, and bromide inhibited the initial velocity of Cl gradient-stimulated SO/sub 4/ uptake, whereas phosphate, ..beta..-hydroxybutyrate, lactate, and p-aminohippurate had not effect. When /sup 35/SO/sub 4/ uptake by BLM vesicles was compared with that of brush-border membrane vesicles, Cl gradient-stimulated SO/sub 4/ uptake was found predominantly in the BLM preparation. In conclusion, these findings provide evidence for a carrier on the ileal basolateral membrane that mediates Cl-SO/sub 4/ exchange.

  19. Piezostrain tuning exchange bias mediated by electric field in composite heterostructure (United States)

    Li, Pingping; Zhou, Cai; Wang, Wenqiang; Cao, Cuimei; Yao, Jinli; Jiang, Changjun


    The change of unidirectional anisotropy and uniaxial anisotropy field turned by piezostrain in an IrMn/Co/Ta/Pb(Mg1/3Nb2/3)O3–PbTiO3 heterostructure with an exchange bias was investigated by ferromagnetic resonance at room temperature. The curve of the magnetic resonance field versus the electric fields showed an asymmetric butterfly-like behavior, which was consistent with the result of strain versus electric field curves. This butterfly-like behavior can be attributed to the piezostrain effect. Specifically, the non-volatile uniaxial anisotropy field and unidirectional anisotropy field behavior under different electric fields induced by piezostrain effect were obtained. Our result is crucial for further application of future multiferroic devices.

  20. Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C{sub 60}) nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Trpkovic, Andreja; Todorovic-Markovic, Biljana; Kleut, Duska; Jovanovic, Svetlana; Dramicanin, Miroslav; Markovic, Zoran [Vinca Institute of Nuclear Sciences, POB 522, University of Belgrade, Belgrade 11000 (Serbia); Misirkic, Maja; Janjetovic, Kristina; Vucicevic, Ljubica [Institute for Biological Research ' Sinisa Stankovic' , University of Belgrade (Serbia); Pantovic, Aleksandar; Trajkovic, Vladimir, E-mail:, E-mail: [Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr Subotica 1, Belgrade 11000 (Serbia)


    The present study investigated the hemolytic properties of fullerene (C{sub 60}) nanoparticles prepared by solvent exchange using tetrahydrofuran (nC{sub 60}THF), or by mechanochemically assisted complexation with macrocyclic oligosaccharide gamma-cyclodextrin (nC{sub 60}CDX) or the copolymer ethylene vinyl acetate-ethylene vinyl versatate (nC{sub 60}EVA-EVV). The spectrophotometrical analysis of hemoglobin release revealed that only nC{sub 60}THF, but not nC{sub 60}CDX or nC{sub 60}EVA-EVV, was able to cause lysis of human erythrocytes in a dose- and time-dependent manner. Atomic force microscopy revealed that nC{sub 60}THF-mediated hemolysis was preceded by erythrocyte shrinkage and increase in cell surface roughness. A flow cytometric analysis confirmed a decrease in erythrocyte size and demonstrated a significant increase in reactive oxygen species production in red blood cells exposed to nC{sub 60}THF. The nC{sub 60}THF-triggered hemolytic activity was efficiently reduced by the antioxidants N-acetylcysteine and butylated hydroxyanisole, as well as by serum albumin, the most abundant protein in human blood plasma. These data indicate that nC{sub 60}THF can cause serum albumin-preventable hemolysis through oxidative stress-mediated damage of the erythrocyte membrane.

  1. Ionic exchange in p-sulfonatocalix[4]arene-mediated formation of metal-ligand complexes. (United States)

    Francisco, Vitor; Basílio, Nuno; García-Río, Luis


    The effect of alkali and transition metal cations in the formation of host-guest complexes with the water-soluble p-sulfonatocalix[4]arene (SC4) was studied using 2-chloropyridine and Na(+) and Cu(2+) as model guest and model cations, respectively. The results obtained from isothermal titration calorimetry and NMR experiments provide evidence for the formation of 1:1:1 ternary complexes for both cations with Cu(2+) showing positive cooperativity and Na(+) negative cooperativity. The formation of ternary complexes comprising transition metal cations has been scarcely explored but present high potential for devising catalytic systems/models or for enhancing the stability and selectivity of SC4 complexes. Because transition metal cations are usually present in solution together with other SC4 countercations (e.g., Na(+)), a general binding model that considers the dynamic formation of all possible complexes (including ionic exchange between ternary complexes) is presented. This model allows the optimization of the conditions required to selectively form target complexes.

  2. Picture Exchange Communication System and Pals: A Peer-Mediated Augmentative and Alternative Communication Intervention for Minimally Verbal Preschoolers with Autism (United States)

    Thiemann-Bourque, Kathy; Brady, Nancy; McGuff, Sara; Strump, Keenan; Naylor, Amy


    Purpose: This study was conducted to investigate the effectiveness of a social intervention that integrates peer-mediated approaches and the Picture Exchange Communication System (PECS). Method: Effects were evaluated using a series of A-B designs replicated across 4 children with severe autism and limited verbal skills. Seven peers without…

  3. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Huiying Shi


    Full Text Available Background/Aims: Dysfunctional autophagy has been reported to be associated with aberrant intestinal metabolism. Amino acids can regulate autophagic activity in intestinal epithelial cells (IECs. Na+/H+-exchanger 3 (NHE3 has been found to participate in the absorption of amino acids in the intestine, but whether NHE3 is involved in the regulation of autophagy in IECs is unclear. Methods: In the present study, an amino acid starvation-induced autophagic model was established. Then, the effects of alanine and proline with or without the NHE inhibitor 5-(N-ethyl-N-isopropyl amiloride (EIPA were evaluated. Autophagy was examined based on the microtubule-associated light chain 3 (LC3 levels, transmission electron microscopy (TEM, tandem GFP-mCherry-LC3 construct, sequestosome-1 (SQSTM1, P62 mRNA and protein levels, and autophagy-related gene (ATG 5, 7, and 12 expression levels. The autophagic flux was evaluated as the ratio of yellow (autophagosomes to red (autolysosomes LC3 puncta. Results: Following amino acid starvation, we found the LC3-II and ATG expression levels were enhanced in the IEC-18 cells. An increase in the number of autophagic vacuoles was concomitantly observed by TEM and confocal microscopy. Based on the results, supplementation with either alanine or proline depressed autophagy in the IEC-18 cells. Consistent with the elevated LC3-II levels, ATG expression increased upon NHE3 inhibition. Moreover, the mCherry-GFP-LC3 autophagic puncta representing both autophagosomes and autolysosomes per cell increased after EIPA treatment. Conclusions: These results demonstrate that NHE (most likely NHE3 may participate in the amino acid regulation of autophagy in IECs, which would aid in the design of better treatments for intestinal inflammation.

  4. Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

    Directory of Open Access Journals (Sweden)

    Laura Ordovás


    Full Text Available Tools for rapid and efficient transgenesis in “safe harbor” loci in an isogenic context remain important to exploit the possibilities of human pluripotent stem cells (hPSCs. We created hPSC master cell lines suitable for FLPe recombinase-mediated cassette exchange (RMCE in the AAVS1 locus that allow generation of transgenic lines within 15 days with 100% efficiency and without random integrations. Using RMCE, we successfully incorporated several transgenes useful for lineage identification, cell toxicity studies, and gene overexpression to study the hepatocyte lineage. However, we observed unexpected and variable transgene expression inhibition in vitro, due to DNA methylation and other unknown mechanisms, both in undifferentiated hESC and differentiating hepatocytes. Therefore, the AAVS1 locus cannot be considered a universally safe harbor locus for reliable transgene expression in vitro, and using it for transgenesis in hPSC will require careful assessment of the function of individual transgenes.

  5. The putative guanine nucleotide exchange factor RicA mediates upstream signaling for growth and development in Aspergillus. (United States)

    Kwon, Nak-Jung; Park, Hee-Soo; Jung, Seunho; Kim, Sun Chang; Yu, Jae-Hyuk


    Heterotrimeric G proteins (G proteins) govern growth, development, and secondary metabolism in various fungi. Here, we characterized ricA, which encodes a putative GDP/GTP exchange factor for G proteins in the model fungus Aspergillus nidulans and the opportunistic human pathogen Aspergillus fumigatus. In both species, ricA mRNA accumulates during vegetative growth and early developmental phases, but it is not present in spores. The deletion of ricA results in severely impaired colony growth and the total (for A. nidulans) or near (for A. fumigatus) absence of asexual sporulation (conidiation). The overexpression (OE) of the A. fumigatus ricA gene (AfricA) restores growth and conidiation in the ΔAnricA mutant to some extent, indicating partial conservation of RicA function in Aspergillus. A series of double mutant analyses revealed that the removal of RgsA (an RGS protein of the GanB Gα subunit), but not sfgA, flbA, rgsB, or rgsC, restored vegetative growth and conidiation in ΔAnricA. Furthermore, we found that RicA can physically interact with GanB in yeast and in vitro. Moreover, the presence of two copies or OE of pkaA suppresses the profound defects caused by ΔAnricA, indicating that RicA-mediated growth and developmental signaling is primarily through GanB and PkaA in A. nidulans. Despite the lack of conidiation, brlA and vosA mRNAs accumulated to normal levels in the ΔricA mutant. In addition, mutants overexpressing fluG or brlA (OEfluG or OEbrlA) failed to restore development in the ΔAnricA mutant. These findings suggest that the commencement of asexual development requires unknown RicA-mediated signaling input in A. nidulans.

  6. Generation of an allelic series of knock-in mice using recombinase-mediated cassette exchange (RMCE). (United States)

    Roebroek, Anton J M; Van Gool, Bart


    Molecular genetic strategies applying embryonic stem cell (ES cell) technologies to study the function of a gene in mice or to generate a mouse model for a human disease are continuously under development. Next to (conditional) inactivation of genes the application and importance of approaches to generate knock-in mutations are increasing. In this chapter the principle and application of recombinase-mediated cassette exchange (RMCE) are discussed as being a new emerging knock-in strategy, which enables easy generation of a series of different knock-in mutations within one gene. An RMCE protocol, which was used to generate a series of different knock-in mutations in the Lrp1 gene of ES cells, is described in detail as an example of how RMCE can be used to generate highly efficiently an allelic series of differently modified ES cell clones from a parental modified ES cell clone. Subsequently the differently modified ES cell clones can be used to generate an allelic series of mutant knock-in mice.

  7. Mediatization

    DEFF Research Database (Denmark)

    Hjarvard, Stig


    Mediatization research shares media effects studies' ambition of answering the difficult questions with regard to whether and how media matter and influence contemporary culture and society. The two approaches nevertheless differ fundamentally in that mediatization research seeks answers...... to these general questions by distinguishing between two concepts: mediation and mediatization. The media effects tradition generally considers the effects of the media to be a result of individuals being exposed to media content, i.e. effects are seen as an outcome of mediated communication. Mediatization....... From the perspective of mediatization research, the most important effect of the media stems from their embeddedness in culture and society....

  8. Estimation of bubble-mediated air-sea gas exchange from concurrent DMS and CO2 transfer velocities at intermediate-high wind speeds (United States)

    Bell, Thomas G.; Landwehr, Sebastian; Miller, Scott D.; de Bruyn, Warren J.; Callaghan, Adrian H.; Scanlon, Brian; Ward, Brian; Yang, Mingxi; Saltzman, Eric S.


    Simultaneous air-sea fluxes and concentration differences of dimethylsulfide (DMS) and carbon dioxide (CO2) were measured during a summertime North Atlantic cruise in 2011. This data set reveals significant differences between the gas transfer velocities of these two gases (Δkw) over a range of wind speeds up to 21 m s-1. These differences occur at and above the approximate wind speed threshold when waves begin breaking. Whitecap fraction (a proxy for bubbles) was also measured and has a positive relationship with Δkw, consistent with enhanced bubble-mediated transfer of the less soluble CO2 relative to that of the more soluble DMS. However, the correlation of Δkw with whitecap fraction is no stronger than with wind speed. Models used to estimate bubble-mediated transfer from in situ whitecap fraction underpredict the observations, particularly at intermediate wind speeds. Examining the differences between gas transfer velocities of gases with different solubilities is a useful way to detect the impact of bubble-mediated exchange. More simultaneous gas transfer measurements of different solubility gases across a wide range of oceanic conditions are needed to understand the factors controlling the magnitude and scaling of bubble-mediated gas exchange.

  9. Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. (United States)

    Thirup, Søren S; Van, Lan Bich; Nielsen, Tine K; Knudsen, Charlotte R


    Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches. All G-proteins require activation via exchange of GDP for GTP to carry out their respective tasks. Often, guanine-nucleotide exchange factors are essential to this process. During translation, EF-Tu:GTP transports aminoacylated tRNA to the ribosome. GTP is hydrolyzed during this process, and subsequent reactivation of EF-Tu is catalyzed by EF-Ts. The reaction path of guanine-nucleotide exchange is structurally poorly defined for EF-Tu and EF-Ts. We have determined the crystal structures of the following reaction intermediates: two structures of EF-Tu:GDP:EF-Ts (2.2 and 1.8Å resolution), EF-Tu:PO4:EF-Ts (1.9Å resolution), EF-Tu:GDPNP:EF-Ts (2.2Å resolution) and EF-Tu:GDPNP:pulvomycin:Mg(2+):EF-Ts (3.5Å resolution). These structures provide snapshots throughout the entire exchange reaction and suggest a mechanism for the release of EF-Tu in its GTP conformation. An inferred sequence of events during the exchange reaction is presented. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Leader-member exchange and work-family interactions: the mediating role of self-reported challenge- and hindrance-related stress. (United States)

    Culbertson, Satoris S; Huffman, Ann H; Alden-Anderson, Rachel


    The authors examined the relations among 4 components of the leader-member exchange (LMX) relationship (i.e., contribution, affect, loyalty, and professional respect) and the level of work-family conflict and work-family facilitation that an employee experiences. Further, the authors examined the mediating role of challenge- and hindrance-related self-reported stress on relations. In doing this, the authors linked positive and negative aspects of LMX, stressors, work-family conflict, and work-family facilitation. Data from a sample of full-time employed individuals support some hypothesized relations between components of LMX and work-family interactions. Also, results support the mediating role of hindrance-related stress in the relation between (a) the affect and loyalty components of LMX and (b) work-family conflict. The authors discuss the implications and limitations of their findings.

  11. Ethical Leadership, Leader-Member Exchange and Feedback Seeking: A Double-Moderated Mediation Model of Emotional Intelligence and Work-Unit Structure. (United States)

    Qian, Jing; Wang, Bin; Han, Zhuo; Song, Baihe


    This research elucidates the role of ethical leadership in employee feedback seeking by examining how and when ethical leadership may exert a positive influence on feedback seeking. Using matched reports from 64 supervisors and 265 of their immediate employees from a hotel group located in a major city in China, we proposed and tested a moderated mediation model that examines leader-member exchange (LMX) as the mediator and emotional intelligence as well as work-unit structure as double moderators in the relationships between ethical leadership and followers' feedback-seeking behavior from supervisors and coworkers. Our findings indicated that (1) LMX mediated the positive relationship between ethical leadership and feedback seeking from both ethical leaders and coworkers, and (2) emotional intelligence and work-unit structure served as joint moderators on the mediated positive relationship in such a way that the relationship was strongest when the emotional intelligence was high and work-unit structure was more of an organic structure rather than a mechanistic structure.

  12. Ethical Leadership, Leader-Member Exchange and Feedback Seeking: A Double-Moderated Mediation Model of Emotional Intelligence and Work-Unit Structure

    Directory of Open Access Journals (Sweden)

    Jing Qian


    Full Text Available This research elucidates the role of ethical leadership in employee feedback seeking by examining how and when ethical leadership may exert a positive influence on feedback seeking. Using matched reports from 64 supervisors and 265 of their immediate employees from a hotel group located in a major city in China, we proposed and tested a moderated mediation model that examines leader-member exchange (LMX as the mediator and emotional intelligence as well as work-unit structure as double moderators in the relationships between ethical leadership and followers’ feedback-seeking behavior from supervisors and coworkers. Our findings indicated that (1 LMX mediated the positive relationship between ethical leadership and feedback seeking from both ethical leaders and coworkers, and (2 emotional intelligence and work-unit structure served as joint moderators on the mediated positive relationship in such a way that the relationship was strongest when the emotional intelligence was high and work-unit structure was more of an organic structure rather than a mechanistic structure.

  13. Ethical Leadership, Leader-Member Exchange and Feedback Seeking: A Double-Moderated Mediation Model of Emotional Intelligence and Work-Unit Structure (United States)

    Qian, Jing; Wang, Bin; Han, Zhuo; Song, Baihe


    This research elucidates the role of ethical leadership in employee feedback seeking by examining how and when ethical leadership may exert a positive influence on feedback seeking. Using matched reports from 64 supervisors and 265 of their immediate employees from a hotel group located in a major city in China, we proposed and tested a moderated mediation model that examines leader-member exchange (LMX) as the mediator and emotional intelligence as well as work-unit structure as double moderators in the relationships between ethical leadership and followers’ feedback-seeking behavior from supervisors and coworkers. Our findings indicated that (1) LMX mediated the positive relationship between ethical leadership and feedback seeking from both ethical leaders and coworkers, and (2) emotional intelligence and work-unit structure served as joint moderators on the mediated positive relationship in such a way that the relationship was strongest when the emotional intelligence was high and work-unit structure was more of an organic structure rather than a mechanistic structure. PMID:28744251

  14. Electron microscopic visualization of the RecA protein-mediated pairing and branch migration phases of DNA strand exchange

    DEFF Research Database (Denmark)

    Register, JC; Christiansen, Gunna; Griffith, J


    The RecA protein of Escherichia coli will drive the pairing and exchange of strands between homologous DNA molecules in a reaction stimulated by single-stranded binding protein. Here, reactions utilizing three homologous DNA pairs which can undergo both paranemic and plectonemic joining were exam...

  15. Implementation of RxNorm as a Terminology Mediation Standard for Exchanging Pharmacy Medication between Federal Agencies (United States)

    Parrish, Fola; Do, Nhan; Bouhaddou, Omar; Warnekar, Pradnya


    The federal government is working toward its goal of achieving interoperability between health information systems through several multi-agency efforts. While some interoperability partnerships exist between federal agencies, only a few systems are involved and these projects have proven difficult to implement. This paper describes the process of implementing an interoperable standard for exchanging computable pharmacy data between the Department of Defense (DoD) and the Department of Veterans Affairs (VA). PMID:17238676

  16. A theoretical analysis of the extraction of heterocyclic organic compounds from an organic phase using chemically mediated electrochemically modulated complexation in ion exchange polymer beads

    Energy Technology Data Exchange (ETDEWEB)

    Ozekin, K.; Noble, R.D.; Koval, C.A.


    A cyclical electrochemical process for the removal of heterocyclic organic compounds (pollutants) from an organic solvent using an ion-exchange polymer is analyzed. In this analysis, there are three main steps: In the first step, the polymer beads containing the active form of the complexing agent are contacted with the contaminated (feed) hydrocarbon phase. The pollutant diffuses into the beads and binds with the complexing agent which is in the reduced state. It is a fast reversible reaction. For the second step, the beads which contain a pollutant are contacted with a waste (receiving) phase and a chemical mediator is then used to oxidize the complexing agent and to reduce its affinity towards the pollutant so that it can be released. The oxidation of the complexing agent is an irreversible reaction. This is a moving boundary problem with countercurrent diffusion. For each mole of mediator that goes into the bead, one mole of pollutant exits since each complexing agent binds one pollutant. In the third step, the waste hydrocarbon phase is removed and a second chemical mediator is then used to reduce the complexing agent. The reduction of the complexing agent is also an irreversible reaction. Partial differential equations are used to analyze this process. 26 refs., 9 figs.

  17. Digital technology use among disadvantaged Australians: implications for equitable consumer participation in digitally-mediated communication and information exchange with health services. (United States)

    Newman, Lareen; Biedrzycki, Kate; Baum, Fran


    To present research findings on access to, and use of, digital information and communication technologies (ICTs) by Australians from lower income and disadvantaged backgrounds to determine implications for equitable consumer access to digitally-mediated health services and information. Focus groups were held in 2008-09 with 80 residents from lower income and disadvantaged backgrounds in South Australia, predominantly of working- and family-formation age (25 to 55 years). Qualitative analysis was conducted on a-priori and emergent themes to describe dominant categories. Access to, and use of, computers, the Internet and mobile phones varied considerably in extent, frequency and quality within and across groups due to differences in abilities, resources and life experience. Barriers and facilitators included English literacy (including for native speakers), technological literacy, education, income, housing situation, social connection, health status, employment status, and trust. Many people gained ICT skills by trial and error or help from friends, and only a few from formal programs, resulting in varied skills. The considerable variation in ICT access and use within lower income and disadvantaged groups must be acknowledged and accommodated by health initiatives and services when delivering digitally-mediated consumer-provider interaction, online health information, or online self-management of health conditions. If services require consumers to participate in a digitally-mediated communication exchange, then we suggest they might support skills and technology acquisition, or provide non-ICT alternatives, in order to avoid exacerbating health inequities.

  18. Seeing through the Screen: Is Evaluative Feedback Communicated More Effectively in Face-to-Face or Computer-Mediated Exchanges? (United States)

    Hebert, Brenda G.; Vorauer, Jacquie D.


    Describes a study of college students that examined how the use of computer mediated communication affected the transmission of performance and interpersonal appraisal information. Examined whether interpersonal judgments obtained through face-to-face communication resulted in greater positivity, but compromised accuracy, relative to…

  19. The development of pedagogical content knowledge in science teachers: New opportunities through technology-mediated reflection and peer-exchange (United States)

    Madeira, M. Cheryl-Ann

    This design-based research study investigates the development of pedagogical content knowledge among nine teacher-participants (N = 9) in three design phases. PCK is a particular type of teacher knowledge that addresses not only the teacher's understanding of the content to be instructed, but also ways of how to teach that content effectively. This knowledge has been well documented over several decades, and is seen as central to teacher expertise. However, its actual development has been difficult for researchers to investigate. This study offers a detailed perspective on how teachers developed PCK with their engagement in lesson planning and enactment of a project-based technology-enhanced lesson. The study includes two specific interventions designed to enhance teachers' development of PCK: (1) scaffolded reflection that occurs throughout the practices; and (2) peer-exchange of lesson plans, enactment ideas, and completed reflections. The findings demonstrate that teachers improve their planning and enactment of project-based technology-enhanced lessons with scaffolded reflection and peer exchange. Positive correlations were seen between teachers' engagement in the reflections and the quality of their lesson planning. Teachers who participated more deeply in the scaffolded reflections were able to understand how their lesson plans and enactment patterns fostered student understanding of relevant science concepts. Positive correlations were also seen between community influence and teacher lesson plans and enactment. Additionally, positive correlations were confirmed between teachers' level of participation in the peer exchange activities and the quality of their lesson planning and enactments. Teachers who contributed more deeply within the online and face-to-face peer community meetings benefited from the different perspectives of their peers about student learning and the best ways to succeed with project-based instruction. This study allowed some insight into

  20. The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells. (United States)

    Kusama, Kazuya; Yoshie, Mikihiro; Tamura, Kazuhiro; Nakayama, Takahiro; Nishi, Hirotaka; Isaka, Keiichi; Tachikawa, Eiichi


    Decidualization of human endometrial stromal cells (ESCs) accompanied by the production of prolactin (PRL) and IGF-binding protein (IGFBP) 1 and rounded-cell morphology is indispensable for the establishment and maintenance of pregnancy. Protein kinase A (PKA)-mediated cAMP signaling is known to be crucial for decidualization. We previously reported that activation of a cAMP mediator, called Exchange protein directly activated by cAMP (EPAC) promotes cAMP analog- or ovarian steroid-induced decidualization in cultured human ESCs. In addition, small interfering RNA-mediated knock-down of the EPAC subtypes, EPAC1 or EPAC2, or knock-down of Rap1, a downstream factor of EPAC signaling, blocked functional and morphological decidualization of ESCs. However, factors downstream of EPAC2 other than Rap1 have not been determined. The present study was undertaken to identify additional downstream targets of EPAC2 associated with decidualization. Using proteomic analysis, we identified calreticulin (CRT) as a potential target of EPAC2. Knock-down of CRT expression in cultured ESCs significantly inhibited PKA-selective cAMP analog- or PKA-selective cAMP analog plus EPAC-selective cAMP analog-induced PRL and IGFBP1 expression. Furthermore, CRT knock-down suppressed the ovarian steroid-stimulated PRL and IGFBP1 expression and morphological differentiation, and silencing of EPAC2 or CRT significantly increased senescence-associated β-galactosidase activity with enhanced p21 expression and decreased p53 expression. These results suggest that EPAC2 and CRT are associated with cellular senescence in ESCs. In conclusion, we demonstrate here that EPAC2-mediated CRT expression is essential for the functional and morphological differentiation of ESCs into decidual cells. Furthermore, both EPAC2 and CRT might prevent ESCs from undergoing abnormal cellular senescence during decidualization.

  1. Co-metal-organic-frameworks with pure uniform crystal morphology prepared via Co2 + exchange-mediated transformation from Zn-metallogels for luminol catalysed chemiluminescence (United States)

    Tang, Xue Qian; Xiao, Bo Wen; Li, Chun Mei; Wang, Dong Mei; Huang, Cheng Zhi; Li, Yuan Fang


    Cation exchange-mediated transformation from Zn-metallogels (MOGs), which was a mild facile strategy relative to the demanding hydrothermal method, was employed to develop Co2 + metal-organic frameworks (Co-MOFs) at room temperature. The obtained Co-MOFs was of uniform octahedral morphology and possessed high activity to catalyze luminol chemiluminescence without extra oxidants. By adding cysteine, the CL emission of luminol-Co-MOFs system was further enhanced. Based on this phenomenon, Co-MOFs was utilized to build a practical sensing platform for cysteine determination. Under the optimized conditions, the relative CL intensity (ΔI) was proportional to the concentration of cysteine in the range of 2-10 μM, and the detection limit was 0.49 μM (3S/N). Moreover, the established method was applied to the determination of cysteine in commercially available pharmaceutical injections.

  2. Guan-Xi, Loyalty, Contribution and ‘Speak-Up Behavior: The Role of Leader-Member Exchange (LMX as Mediator and Political Skill as Moderator

    Directory of Open Access Journals (Sweden)

    Chin-Yi Shu


    Full Text Available This study investigates factors that encourage employee’s speaking-up behavior in the organization which is considered to be a risky behavior. Drawing on the principles of Uncertainty Management Theory (UMT, this research proposes that factors which embodies two key facets of certainty, confidence and control, encourages employees to speak-up to direct supervisors. This study proposes that leader-member exchange (LMX has a mediating effect on the relationship between Cheng’s categorization criteria (guan-xi, loyalty, contribution and speak-up behavior while political skill moderates the relationship between LMX and speak-up behavior. Data collected from 288 subordinates and 92 of their immediate supervisors support all hypotheses. This study reveals the effects of LMX and political skill, on ‘speak-up’ behavior and provides practical suggestions to aid employees and organizations maximize the potential of their workforce.

  3. Green Synthesis of ZnO Nanoparticles by an Alginate Mediated Ion-Exchange Process and a case study for Photocatalysis of Methylene Blue Dye (United States)

    Keong, Choo Cheng; Sunitha Vivek, Yamini; Salamatinia, Babak; Amini Horri, Bahman


    In this study, zinc oxide (ZnO) was prepared via extrusion-dripping method through an ion exchange mediated process using sodium alginate. The samples were synthesized at 500 °C and 600 °C to study the effect of calcination temperature. The morphology, microstructure and optical activity of the calcined ZnO nanoparticles were analyzed by TGA, FESEM and XRD. It was found that ZnO nanoparticles synthesized at 600 °C was of higher purity with high crystallinity. To enhance the photocatalytic efficiency of zinc oxide, ZnO/NCC films were synthesized at varying ZnO loading fractions of 10 wt%, 15 wt%, 20 wt% and 25 wt% and were evaluated by photodegradation of Methylene blue dye and the highest dye percentage removal is found to be 96% which is obtained at ZnO loadings of 25 wt%. The usage of ion-exchange process has shown promising results in producing ZnO of desirable characteristics.

  4. Preselection of recombinant gene integration sites enabling high transcription rates in CHO cells using alternate start codons and recombinase mediated cassette exchange. (United States)

    Baumann, Martina; Gludovacz, Elisabeth; Sealover, Natalie; Bahr, Scott; George, Henry; Lin, Nan; Kayser, Kevin; Borth, Nicole


    Site-specific recombinase mediated cassette exchange (RMCE) enables the transfer of the gene of interest (GOI) into pre-selected genomic locations with defined expression properties. For the generation of recombinant production cell lines, this has the advantage that screening for high transcription rates at the genome integration site would be required only once, with the possibility to reuse the selected site for new products. Here, we describe a strategy that aims at the selection of transcriptionally active genome integration sites in Chinese Hamster Ovary (CHO) cells by using alternate start codons in the surface reporter protein CD4, in combination with FACS sorting for high expressers. The alternate start codon reduces the translation initiation efficiency and allows sorting for CHO cells with the highest transcription rates, while RMCE enables the subsequent exchange of the CD4 against the GOI. We have shown that sorted cell pools with the CD4 reporter gene containing the alternate start codon CTG lead to higher GFP signals and higher antibody titers upon RMCE as compared to cell pools containing the ATG start codon of the CD4 reporter. Despite the absence of any subcloning step, the final cell pool contained the CD4 gene in a single genome integration site. © 2017 Wiley Periodicals, Inc.

  5. Ligand Exchange-Mediated Activation and Stabilization of a Re-Based Olefin Metathesis Catalyst by Chlorinated Alumina. (United States)

    Gallo, Alessandro; Fong, Anthony; Szeto, Kai C; Rieb, Julia; Delevoye, Laurent; Gauvin, Régis M; Taoufik, Mostafa; Peters, Baron; Scott, Susannah L


    Extensive chlorination of γ-Al2O3 results in the formation of highly Lewis acidic surface domains depleted in surface hydroxyl groups. Adsorption of methyltrioxorhenium (MTO) onto these chlorinated domains serves to activate it as a low temperature, heterogeneous olefin metathesis catalyst and confers both high activity and high stability. Characterization of the catalyst reveals that the immobilized MTO undergoes partial ligand exchange with the surface, whereby some Re sites acquire a chloride ligand from the modified alumina while donating an oxo ligand to the support. More specifically, Re LIII-edge EXAFS and DFT calculations support facile ligand exchange between MTO and Cl-Al2O3 to generate [CH3ReO2Cl(+)] fragments that interact with a bridging oxygen of the support via a Lewis acid-base interaction. According to IR and solid-state NMR, the methyl group remains intact, and does not evolve spontaneously to a stable methylene tautomer. Nevertheless, the chloride-promoted metathesis catalyst is far more active and productive than MTO/γ-Al2O3, easily achieving a TON of 100 000 for propene metathesis in a flow reactor at 10 °C (compared to TON < 5000 for the nonchlorinated catalyst). Increased activity is a consequence of both a larger fraction of active sites and a higher intrinsic activity for the new sites. Increased stability is tentatively attributed to a stronger interaction between MTO and chlorinated surface regions, as well as extensive depletion of the Brønsted acidic surface hydroxyl population. The reformulated catalyst represents a major advance for Re-based metathesis catalysts, whose widespread use has thus far been severely hampered by their instability.

  6. Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. (United States)

    Takenaka, Nobuyuki; Yasuda, Naoto; Nihata, Yuma; Hosooka, Tetsuya; Noguchi, Tetsuya; Aiba, Atsu; Satoh, Takaya


    The small GTPase Rac1 plays a key role in insulin-promoted glucose uptake mediated by the GLUT4 glucose transporter in skeletal muscle. Our recent studies have demonstrated that the serine/threonine protein kinase Akt2 is critically involved in insulin-dependent Rac1 activation. The purpose of this study is to clarify the role of the guanine nucleotide exchange factor FLJ00068 in Akt2-mediated Rac1 activation and GLUT4 translocation in mouse skeletal muscle and cultured myocytes. Constitutively activated FLJ00068 induced GLUT4 translocation in a Rac1-dependent and Akt2-independent manner in L6 myocytes. On the other hand, knockdown of FLJ00068 significantly reduced constitutively activated Akt2-triggered GLUT4 translocation. Furthermore, Rac1 activation and GLUT4 translocation induced by constitutively activated phosphoinositide 3-kinase were inhibited by knockdown of FLJ00068. In mouse gastrocnemius muscle, constitutively activated FLJ00068 actually induced GLUT4 translocation to the sarcolemma. GLUT4 translocation by constitutively activated FLJ00068 was totally abolished in rac1 knockout mouse gastrocnemius muscle. Additionally, we were successful in detecting the activation of Rac1 following the expression of constitutively activated FLJ00068 in gastrocnemius muscle by immunofluorescence microscopy using an activation-specific probe. Collectively, these results strongly support the notion that FLJ00068 regulates Rac1 downstream of Akt2, leading to the stimulation of glucose uptake in skeletal muscle. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle.

    Directory of Open Access Journals (Sweden)

    Nobuyuki Takenaka

    Full Text Available Insulin-stimulated glucose uptake in skeletal muscle is mediated by the glucose transporter GLUT4, which is translocated to the plasma membrane following insulin stimulation. Several lines of evidence suggested that the protein kinase Akt2 plays a key role in this insulin action. The small GTPase Rac1 has also been implicated as a regulator of insulin-stimulated GLUT4 translocation, acting downstream of Akt2. However, the mechanisms whereby Akt2 regulates Rac1 activity remain obscure. The guanine nucleotide exchange factor FLJ00068 has been identified as a direct regulator of Rac1 in Akt2-mediated signaling, but its characterization was performed mostly in cultured myoblasts. Here, we provide in vivo evidence that FLJ00068 indeed acts downstream of Akt2 as a Rac1 regulator by using mouse skeletal muscle. Small interfering RNA knockdown of FLJ00068 markedly diminished GLUT4 translocation to the sarcolemma following insulin administration or ectopic expression of a constitutively activated mutant of either phosphoinositide 3-kinase or Akt2. Additionally, insulin and these constitutively activated mutants caused the activation of Rac1 as shown by immunofluorescent microscopy using a polypeptide probe specific to activated Rac1 in isolated gastrocnemius muscle fibers and frozen sections of gastrocnemius muscle. This Rac1 activation was also abrogated by FLJ00068 knockdown. Furthermore, we observed translocation of FLJ00068 to the cell periphery following insulin stimulation in cultured myoblasts. Localization of FLJ00068 in the plasma membrane in insulin-stimulated, but not unstimulated, myoblasts and mouse gastrocnemius muscle was further affirmed by subcellular fractionation and subsequent immunoblotting. Collectively, these results strongly support a critical role of FLJ00068 in Akt2-mediated Rac1 activation in mouse skeletal muscle insulin signaling.

  8. Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs (United States)

    Waadt, Rainer; Schroeder, Julian I.


    The phytohormone abscisic acid (ABA) is critical to plant development and stress responses. Abiotic stress triggers an ABA signal transduction cascade, which is comprised of the core components PYL/RCAR ABA receptors, PP2C-type protein phosphatases, and protein kinases. Small GTPases of the ROP/RAC family act as negative regulators of ABA signal transduction. However, the mechanisms by which ABA controls the behavior of ROP/RACs have remained unclear. Here, we show that an Arabidopsis guanine nucleotide exchange factor protein RopGEF1 is rapidly sequestered to intracellular particles in response to ABA. GFP-RopGEF1 is sequestered via the endosome-prevacuolar compartment pathway and is degraded. RopGEF1 directly interacts with several clade A PP2C protein phosphatases, including ABI1. Interestingly, RopGEF1 undergoes constitutive degradation in pp2c quadruple abi1/abi2/hab1/pp2ca mutant plants, revealing that active PP2C protein phosphatases protect and stabilize RopGEF1 from ABA-mediated degradation. Interestingly, ABA-mediated degradation of RopGEF1 also plays an important role in ABA-mediated inhibition of lateral root growth. The presented findings point to a PP2C-RopGEF-ROP/RAC control loop model that is proposed to aid in shutting off ABA signal transduction, to counteract leaky ABA signal transduction caused by “monomeric” PYL/RCAR ABA receptors in the absence of stress, and facilitate signaling in response to ABA. PMID:27192441

  9. Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Francesca Finetti


    Full Text Available The cell’s ability to communicate with the extracellular environment, with other cells, and with itself is a crucial feature of eukaryotic organisms. In the immune system, T lymphocytes assemble a specialized structure upon contact with antigen-presenting cells bearing a peptide-major histocompatibility complex ligand, known as the immunological synapse (IS. The IS has been extensively characterized as a signaling platform essential for T-cell activation. Moreover, emerging evidence identifies the IS as a device for vesicular traffic-mediated cell-to-cell communication as well as an active release site of soluble molecules. Here, we will review recent advances in the role of vesicular trafficking in IS assembly and focused secretion of microvesicles at the synaptic area in naïve T cells and discuss the role of the IS in transcellular communication.

  10. Nuclear magnetic relaxation induced by exchange-mediated orientational randomization: Longitudinal relaxation dispersion for a dipole-coupled spin-1/2 pair (United States)

    Chang, Zhiwei; Halle, Bertil


    In complex biological or colloidal samples, magnetic relaxation dispersion (MRD) experiments using the field-cycling technique can characterize molecular motions on time scales ranging from nanoseconds to microseconds, provided that a rigorous theory of nuclear spin relaxation is available. In gels, cross-linked proteins, and biological tissues, where an immobilized macromolecular component coexists with a mobile solvent phase, nuclear spins residing in solvent (or cosolvent) species relax predominantly via exchange-mediated orientational randomization (EMOR) of anisotropic nuclear (electric quadrupole or magnetic dipole) couplings. The physical or chemical exchange processes that dominate the MRD typically occur on a time scale of microseconds or longer, where the conventional perturbation theory of spin relaxation breaks down. There is thus a need for a more general relaxation theory. Such a theory, based on the stochastic Liouville equation (SLE) for the EMOR mechanism, is available for a single quadrupolar spin I = 1. Here, we present the corresponding theory for a dipole-coupled spin-1/2 pair. To our knowledge, this is the first treatment of dipolar MRD outside the motional-narrowing regime. Based on an analytical solution of the spatial part of the SLE, we show how the integral longitudinal relaxation rate can be computed efficiently. Both like and unlike spins, with selective or non-selective excitation, are treated. For the experimentally important dilute regime, where only a small fraction of the spin pairs are immobilized, we obtain simple analytical expressions for the auto-relaxation and cross-relaxation rates which generalize the well-known Solomon equations. These generalized results will be useful in biophysical studies, e.g., of intermittent protein dynamics. In addition, they represent a first step towards a rigorous theory of water 1H relaxation in biological tissues, which is a prerequisite for unravelling the molecular basis of soft

  11. Sodium-calcium exchanger and R-type Ca(2+) channels mediate spontaneous [Ca(2+)]i oscillations in magnocellular neurones of the rat supraoptic nucleus. (United States)

    Kortus, Stepan; Srinivasan, Chinnapaiyan; Forostyak, Oksana; Zapotocky, Martin; Ueta, Yoichi; Sykova, Eva; Chvatal, Alexandr; Verkhratsky, Alexei; Dayanithi, Govindan


    Isolated supraoptic neurones generate spontaneous [Ca(2+)]i oscillations in isolated conditions. Here we report in depth analysis of the contribution of plasmalemmal ion channels (Ca(2+), Na(+)), Na(+)/Ca(2+) exchanger (NCX), intracellular Ca(2+) release channels (InsP3Rs and RyRs), Ca(2+) storage organelles, plasma membrane Ca(2+) pump and intracellular signal transduction cascades into spontaneous Ca(2+) activity. While removal of extracellular Ca(2+) or incubation with non-specific voltage-gated Ca(2+) channel (VGCC) blocker Cd(2+) suppressed the oscillations, neither Ni(2+) nor TTA-P2, the T-type VGCC blockers, had an effect. Inhibitors of VGCC nicardipine, ω-conotoxin GVIA, ω-conotoxin MVIIC, ω-agatoxin IVA (for L-, N-, P and P/Q-type channels, respectively) did not affect [Ca(2+)]i oscillations. In contrast, a specific R-type VGCC blocker SNX-482 attenuated [Ca(2+)]i oscillations. Incubation with TTX had no effect, whereas removal of the extracellular Na(+) or application of an inhibitor of the reverse operation mode of Na(+)/Ca(2+) exchanger KB-R7943 blocked the oscillations. The mitochondrial uncoupler CCCP irreversibly blocked spontaneous [Ca(2+)]i activity. Exposure of neurones to Ca(2+) mobilisers (thapsigargin, cyclopiazonic acid, caffeine and ryanodine); 4-aminopyridine (A-type K(+) current blocker); phospholipase C and adenylyl cyclase pathways blockers U-73122, Rp-cAMP, SQ-22536 and H-89 had no effect. Oscillations were blocked by GABA, but not by glutamate, apamin or dynorphin. In conclusion, spontaneous oscillations in magnocellular neurones are mediated by a concerted action of R-type Ca(2+) channels and the NCX fluctuating between forward and reverse modes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation

    Directory of Open Access Journals (Sweden)

    Fox Jane


    Full Text Available Abstract Background Agonist stimulation of airway smooth muscle (ASM results in IP3 mediated Ca2+ release from the sarcoplasmic reticulum followed by the activation of store operated and receptor operated non-selective cation channels. Activation of these non-selective channels also results in a Na+ influx. This localised increase in Na+ levels can potentially switch the Na+/Ca2+ exchanger into reverse mode and so result in a further influx of Ca2+. The aim of this study was to characterise the expression and physiological function of the Na+/Ca2+ exchanger in cultured human bronchial smooth muscle cells and determine its contribution to agonist induced Ca2+ influx into these cells. Methods The expression profile of NCX (which encodes the Na+/Ca2+ exchanger homologues in cultured human bronchial smooth muscle cells was determined by reverse transcriptase PCR. The functional activity of reverse mode NCX was investigated using a combination of whole cell patch clamp, intracellular Ca2+ measurements and porcine airway contractile analyses. KB-R7943 (an antagonist for reverse mode NCX and target specific siRNA were utilised as tools to inhibit NCX function. Results NCX1 protein was detected in cultured human bronchial smooth muscle cells (HBSMC cells and NCX1.3 was the only mRNA transcript variant detected. A combination of intracellular Na+ loading and addition of extracellular Ca2+ induced an outwardly rectifying current which was augmented following stimulation with histamine. This outwardly rectifying current was inhibited by 10 μM KB-R7943 (an antagonist of reverse mode NCX1 and was reduced in cells incubated with siRNA against NCX1. Interestingly, this outwardly rectifying current was also inhibited following knockdown of STIM1, suggesting for the first time a link between store operated cation entry and NCX1 activation. In addition, 10 μM KB-R7943 inhibited agonist induced changes in cytosolic Ca2+ and induced relaxation of porcine

  13. Residues 28 to 39 of the Extracellular Loop 1 of Chicken Na+/H+ Exchanger Type I Mediate Cell Binding and Entry of Subgroup J Avian Leukosis Virus. (United States)

    Guan, Xiaolu; Zhang, Yao; Yu, Mengmeng; Ren, Chaoqi; Gao, Yanni; Yun, Bingling; Liu, Yongzhen; Wang, Yongqiang; Qi, Xiaole; Liu, Changjun; Cui, Hongyu; Zhang, Yanping; Gao, Li; Li, Kai; Pan, Qing; Zhang, Baoshan; Wang, Xiaomei; Gao, Yulong


    Chicken Na+/H+ exchanger type I (chNHE1), a multispan transmembrane protein, is a cellular receptor of the subgroup J avian leukosis virus (ALV-J). To identify the functional determinants of chNHE1 responsible for the ALV-J receptor activity, a series of chimeric receptors was created by exchanging the extracellular loops (ECL) of human NHE1 (huNHE1) and chNHE1 and by ECL replacement with a hemagglutinin (HA) tag. These chimeric receptors then were used in binding and entry assays to map the minimal ALV-J gp85-binding domain of chNHE1. We show that ECL1 of chNHE1 (chECL1) is the critical functional ECL that interacts directly with ALV-J gp85; ECL3 is also involved in ALV-J gp85 binding. Amino acid residues 28 to 39 of the N-terminal membrane-proximal region of chECL1 constitute the minimal domain required for chNHE1 binding of ALV-J gp85. These residues are sufficient to mediate viral entry into ALV-J nonpermissive cells. Point mutation analysis revealed that A30, V33, W38, and E39 of chECL1 are the key residues mediating the binding between chNHE1 and ALV-J gp85. Further, the replacement of residues 28 to 39 of huNHE1 with the corresponding chNHE1 residues converted the nonfunctional ALV-J receptor huNHE1 to a functional one. Importantly, soluble chECL1 and huECL1 harboring chNHE1 residues 28 to 39 both could effectively block ALV-J infection. Collectively, our findings indicate that residues 28 to 39 of chNHE1 constitute a domain that is critical for receptor function and mediate ALV-J entry.IMPORTANCE chNHE1 is a cellular receptor of ALV-J, a retrovirus that causes infections in chickens and serious economic losses in the poultry industry. Until now, the domains determining the chNHE1 receptor function remained unknown. We demonstrate that chECL1 is critical for receptor function, with residues 28 to 39 constituting the minimal functional domain responsible for chNHE1 binding of ALV-J gp85 and efficiently mediating ALV-J cell entry. These residues are located in

  14. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.

    Directory of Open Access Journals (Sweden)

    Melissa C Srougi


    Full Text Available Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem. A member of the Rho family of small GTPases, RhoB has been shown to be integral in mediating cell death after ionizing radiation (IR or other DNA damaging agents in Ras-transformed cell lines. In addition, RhoB protein expression increases after genotoxic stress, and loss of RhoB expression causes radio- and chemotherapeutic resistance. However, the signaling pathways that govern RhoB-induced cell death after DNA damage remain enigmatic. Here, we show that RhoB activity increases in human breast and cervical cancer cell lines after treatment with DNA damaging agents. Furthermore, RhoB activity is necessary for DNA damage-induced cell death, as the stable loss of RhoB protein expression using shRNA partially protects cells and prevents the phosphorylation of c-Jun N-terminal kinases (JNKs and the induction of the pro-apoptotic protein Bim after IR. The increase in RhoB activity after genotoxic stress is associated with increased activity of the nuclear guanine nucleotide exchange factors (GEFs, Ect2 and Net1, but not the cytoplasmic GEFs p115 RhoGEF or Vav2. Importantly, loss of Ect2 and Net1 via siRNA-mediated protein knock-down inhibited IR-induced increases in RhoB activity, reduced apoptotic signaling events, and protected cells from IR-induced cell death. Collectively, these data suggest a mechanism involving the nuclear GEFs Ect2 and Net1 for activating RhoB after genotoxic stress, thereby facilitating cell death after treatment with DNA damaging agents.

  15. Increased sodium/calcium exchanger activity enhances beta-adrenergic-mediated increase in heart rate: Whole-heart study in a homozygous sodium/calcium exchanger overexpressor mouse model. (United States)

    Kaese, Sven; Bögeholz, Nils; Pauls, Paul; Dechering, Dirk; Olligs, Jan; Kölker, Katharina; Badawi, Sascha; Frommeyer, Gerrit; Pott, Christian; Eckardt, Lars


    The cardiac sodium/calcium (Na(+)/Ca(2+)) exchanger (NCX) contributes to diastolic depolarization in cardiac pacemaker cells. Increased NCX activity has been found in heart failure and atrial fibrillation. The influence of increased NCX activity on resting heart rate, beta-adrenergic-mediated increase in heart rate, and cardiac conduction properties is unknown. The purpose of this study was to investigate the influence of NCX overexpression in a homozygous transgenic whole-heart mouse model (NCX-OE) on sinus and AV nodal function. Langendorff-perfused, beating whole hearts of NCX-OE and the corresponding wild-type (WT) were studied ± isoproterenol (ISO; 0.2 μM). Epicardial ECG, AV nodal Wenckebach cycle length (AVN-WCL), and retrograde AVN-WCL were obtained. At baseline, basal heart rate was unaltered between NCX-OE and WT (WT: cycle length [CL] 177.6 ± 40.0 ms, no. of hearts [n] = 20; NCX-OE: CL 185.9 ± 30.5 ms, n = 18; P = .21). In the presence of ISO, NCX-OE exhibited a significantly higher heart rate compared to WT (WT: CL 133.4 ± 13.4 ms, n = 20; NCX-OE: CL 117.7 ± 14.2 ms, n = 18; P heart rate. Mechanistically, increased NCX inward mode activity may promote acceleration of diastolic depolarization in sinus nodal pacemaker cells, thus enhancing chronotropy in NCX-OE. These findings suggest a novel potential therapeutic target for heart rate control in the presence of increased NCX activity, such as heart failure. Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  16. Influence of ionic liquids as electrolyte additives on chiral separation of dansylated amino acids by using Zn(II) complex mediated chiral ligand exchange CE. (United States)

    Zhang, Haizhi; Qi, Li; Mu, Xiaoyu; Zhou, Xiaoping; Li, Dan; Mao, Lanqun


    In this work, investigation of the comparative influence of diverse ionic liquids (ILs) as electrolyte additives on the chiral separation of dansylated amino acids by using Zn(II)-L-arginine complex mediated chiral ligand exchange CE (CLE-CE) was conducted. It has been found that not only the varied substituted group number, but also the alkyl chain length of the substituted group on imidazole ring in the structure of ILs show different influence on chiral separation of the analytes in the CLE-CE system, which could be understood by their direct influence on EOF. Meanwhile, the variation of anion in the structure of ILs displayed remarkably changed performance and the ILs with Cl(-) showed the most obvious promoting effect on the chiral separation performance. Among the investigated seven ILs, 1-butyl-3-methylimidazolium chloride was validated to be the proper electrolyte additive in the CLE-CE system. Moreover, it has been observed that 1-butyl-3-methylimidazolium chloride also has obvious promotive effect on the labeling performance. The results have demonstrated that the ILs with different structures have important relation to their performance in CLE-CE and to their labeling efficiency in dansylation of the analytes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Barter exchanges

    DEFF Research Database (Denmark)

    Sudzina, Frantisek

    Although barter is often perceived as something that proceeded money, barter is still used. The focus of the paper is on barter exchanges. Barter exchanges are used both in developing countries as well as in developed countries (including the U.S.). They are used by both organizations...... and individuals. They usually allow to exchange good but some include also services. Some exchanges allow only for bi-directional barter, i.e. when only two parties are involved in the exchange. But probably most of the barter exchanges use barter money; this makes it easier to exchange goods and services...

  18. Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament.

    KAUST Repository

    Fornander, Louise H


    The Swi5-Sfr1 heterodimer protein stimulates the Rad51-promoted DNA strand exchange reaction, a crucial step in homologous recombination. To clarify how this accessory protein acts on the strand exchange reaction, we have analyzed how the structure of the primary reaction intermediate, the Rad51/single-stranded DNA (ssDNA) complex filament formed in the presence of ATP, is affected by Swi5-Sfr1. Using flow linear dichroism spectroscopy, we observe that the nucleobases of the ssDNA are more perpendicularly aligned to the filament axis in the presence of Swi5-Sfr1, whereas the bases are more randomly oriented in the absence of Swi5-Sfr1. When using a modified version of the natural protein where the N-terminal part of Sfr1 is deleted, which has no affinity for DNA but maintained ability to stimulate the strand exchange reaction, we still observe the improved perpendicular DNA base orientation. This indicates that Swi5-Sfr1 exerts its activating effect through interaction with the Rad51 filament mainly and not with the DNA. We propose that the role of a coplanar alignment of nucleobases induced by Swi5-Sfr1 in the presynaptic Rad51/ssDNA complex is to facilitate the critical matching with an invading double-stranded DNA, hence stimulating the strand exchange reaction.

  19. Transport of H2S and HS(-) across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl(-)/HS(-) exchange. (United States)

    Jennings, Michael L


    The rates of H2S and HS(-) transport across the human erythrocyte membrane were estimated by measuring rates of dissipation of pH gradients in media containing 250 μM H2S/HS(-). Net acid efflux is caused by H2S/HS(-) acting analogously to CO2/HCO3(-) in the Jacobs-Stewart cycle. The steps are as follows: 1) H2S efflux through the lipid bilayer and/or a gas channel, 2) extracellular H2S deprotonation, 3) HS(-) influx in exchange for Cl(-), catalyzed by the anion exchange protein AE1, and 4) intracellular HS(-) protonation. Net acid transport by the Cl(-)/HS(-)/H2S cycle is more efficient than by the Cl(-)/HCO3(-)/CO2 cycle because of the rapid H2S-HS(-) interconversion in cells and medium. The rates of acid transport were analyzed by solving the mass flow equations for the cycle to produce estimates of the HS(-) and H2S transport rates. The data indicate that HS(-) is a very good substrate for AE1; the Cl(-)/HS(-) exchange rate is about one-third as rapid as Cl(-)/HCO3(-) exchange. The H2S permeability coefficient must also be high (>10(-2) cm/s, half time <0.003 s) to account for the pH equilibration data. The results imply that H2S and HS(-) enter erythrocytes very rapidly in the microcirculation of H2S-producing tissues, thereby acting as a sink for H2S and lowering the local extracellular concentration, and the fact that HS(-) is a substrate for a Cl(-)/HCO3(-) exchanger indicates that some effects of exogenous H2S/HS(-) may not result from a regulatory role of H2S but, rather, from net acid flux by H2S and HS(-) transport in a Jacobs-Stewart cycle.

  20. Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis.

    Directory of Open Access Journals (Sweden)

    Daniel Laubitz

    Full Text Available Inflammatory bowel diseases (IBD are associated with functional inhibition of epithelial Na+/H+ exchange. In mice, a selective disruption of NHE3 (Slc9a3, a major apical Na+/H+ exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis. We hypothesized that disruption of Na+/H+ exchange is necessary for the development of dysbiosis, which promotes an exacerbated mucosal inflammatory response. Therefore, we performed a temporal analysis of gut microbiota composition, and mucosal immune response to adoptive T cell transfer was evaluated in Rag2-/- and NHE3-/-/Rag2-/- (DKO mice with and without broad-spectrum antibiotics. Microbiome (16S profiling, colonic histology, T cell and neutrophil infiltration, mucosal inflammatory tone, and epithelial permeability were analyzed. In adoptive T cell transfer colitis model, Slc9a3 status was the most significant determinant of gut microbial community. In DKO mice, NHE3-deficiency and dysbiosis were associated with dramatically accelerated and exacerbated disease, with rapid body weight loss, increased mucosal T cell and neutrophil influx, increased mucosal cytokine expression, increased permeability, and expansion of CD25-FoxP3+ Tregs; this enhanced susceptibility was alleviated by oral broad-spectrum antibiotics. Based on these results and our previous work, we postulate that epithelial electrolyte homeostasis is an important modulator in the progression of colitis, acting through remodeling of the gut microbial community.

  1. Dynamic equilibria in solvent-mediated anion, cation and ligand exchange in transition-metal coordination polymers: solid-state transfer or recrystallisation? (United States)

    Cui, Xianjin; Khlobystov, Andrei N; Chen, Xinyong; Marsh, Dan H; Blake, Alexander J; Lewis, William; Champness, Neil R; Roberts, Clive J; Schröder, Martin


    The solution properties of a series of transition-metal-ligand coordination polymers [ML(X)(n)](infinity) [M=Ag(I), Zn(II), Hg(II) and Cd(II); L=4,4'-bipyridine (4,4'-bipy), pyrazine (pyz), 3,4'-bipyridine (3,4'-bipy), 4-(10-(pyridin-4-yl)anthracen-9-yl)pyridine (anbp); X=NO(3) (-), CH(3)COO(-), CF(3)SO(3) (-), Cl(-), BF(4) (-); n=1 or 2] in the presence of competing anions, metal cations and ligands have been investigated systematically. Providing that the solubility of the starting complex is sufficiently high, all the components of the coordination polymer, namely the anion, the cation and the ligand, can be exchanged on contact with a solution phase of a competing component. The solubility of coordination polymers is a key factor in the analysis of their reactivity and this solubility depends strongly on the physical properties of the solvent and on its ability to bind metal cations constituting the backbone of the coordination polymer. The degree of reversibility of these solvent-induced anion-exchange transformations is determined by the ratio of the solubility product constants for the starting and resultant complexes, which in turn depend upon the choice of solvent and the temperature. The extent of anion exchange is controlled effectively by the ratio of the concentrations of incoming ions to outgoing ions in the liquid phase and the solvation of various constituent components comprising the coordination polymer. These observations can be rationalised in terms of a dynamic equilibrium of ion exchange reactions coupled with Ostwald ripening of crystalline products. The single-crystal X-ray structures of [Ag(pyz)ClO(4)](infinity) (1), {[Ag(4,4'-bipy)(CF(3)SO(3))]CH(3)CN}(infinity) (2), {[Ag(4,4'-bipy)(CH(3)CN)]ClO(4) 0.5 CH(3)CN}(infinity) (3), metal-free anbp (4), [Ag(anbp)NO(3)(H(2)O)](infinity) (5), {[Cd(4,4'-bipy)(2)(H(2)O)(2)](NO(3))(2)4 H(2)O}(infinity) (6) and {[Zn(4,4'-bipy)SO(4)(H(2)O)(3)] 2 H(2)O}(infinity) (7) are reported.

  2. Exchange Network (United States)

    The Environmental Information Exchange Network (EIEN) is an Internet-based system used by state, tribal and territorial partners to securely share environmental and health information with one another and EPA.

  3. Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells. (United States)

    Beltrán, Ana R; Carraro-Lacroix, Luciene R; Bezerra, Camila N A; Cornejo, Marcelo; Norambuena, Katrina; Toledo, Fernando; Araos, Joaquín; Pardo, Fabián; Leiva, Andrea; Sanhueza, Carlos; Malnic, Gerhard; Sobrevia, Luis; Ramírez, Marco A


    The enterotoxigenic Escherichia coli strains lead to diarrhoea in humans due to heat-labile and heat-stable (STa) enterotoxins. STa increases Cl-release in intestinal cells, including the human colonic carcinoma T84 cell line, involving increased cGMP and membrane alkalization due to reduced Na+/H+ exchangers (NHEs) activity. Since NHEs modulate intracellular pH (pHi), and NHE1, NHE2, and NHE4 are expressed in T84 cells, we characterized the STa role as modulator of these exchangers. pHi was assayed by the NH4Cl pulse technique and measured by fluorescence microscopy in BCECF-preloaded cells. pHi recovery rate (dpHi/dt) was determined in the absence or presence of 0.25 μmol/L STa (30 minutes), 25 μmol/L HOE-694 (concentration inhibiting NHE1 and NHE2), 500 μmol/L sodium nitroprusside (SNP, spontaneous nitric oxide donor), 100 μmol/L dibutyryl cyclic GMP (db-cGMP), 100 nmol/L H89 (protein kinase A inhibitor), or 10 μmol/L forskolin (adenylyl cyclase activator). cGMP and cAMP were measured in cell extracts by radioimmunoassay, and buffering capacity (ßi) and H+ efflux (JH+) was determined. NHE4 protein abundance was determined by western blotting. STa and HOE-694 caused comparable reduction in dpHi/dt and JH+ (~63%), without altering basal pHi (range 7.144-7.172). STa did not alter ßi value in a range of 1.6 pHi units. The dpHi/dt and JH+ was almost abolished (~94% inhibition) by STa + HOE-694. STa effect was unaltered by db-cGMP or SNP. However, STa and forskolin increased cAMP level. STa-decreased dpHi/dt and JH+ was mimicked by forskolin, and STa + HOE-694 effect was abolished by H89. Thus, incubation of T84 cells with STa results in reduced NHE4 activity leading to a lower capacity of pHi recovery requiring cAMP, but not cGMP. STa effect results in a causal phenomenon (STa/increased cAMP/increased PKA activity/reduced NHE4 activity) ending with intracellular acidification that could have consequences in the gastrointestinal cells function promoting human

  4. Hydrogen exchange

    DEFF Research Database (Denmark)

    Jensen, Pernille Foged; Rand, Kasper Dyrberg


    Hydrogen exchange (HX) monitored by mass spectrometry (MS) is a powerful analytical method for investigation of protein conformation and dynamics. HX-MS monitors isotopic exchange of hydrogen in protein backbone amides and thus serves as a sensitive method for probing protein conformation...... and dynamics along the entire protein backbone. This chapter describes the exchange of backbone amide hydrogen which is highly quenchable as it is strongly dependent on the pH and temperature. The HX rates of backbone amide hydrogen are sensitive and very useful probes of protein conformation......, as they are distributed along the polypeptide backbone and form the fundamental hydrogen-bonding networks of basic secondary structure. The effect of pressure on HX in unstructured polypeptides (poly-dl-lysine and oxidatively unfolded ribonuclease A) and native folded proteins (lysozyme and ribonuclease A) was evaluated...

  5. Exchange Options

    NARCIS (Netherlands)

    Jamshidian, F.


    The contract is described and market examples given. Essential theoretical developments are introduced and cited chronologically. The principles and techniques of hedging and unique pricing are illustrated for the two simplest nontrivial examples: the classical Black-Scholes/Merton/Margrabe exchange

  6. Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression. (United States)

    Farag, Maged Ibrahim; Yoshikawa, Yoko; Maeta, Kazuhiro; Kataoka, Tohru


    Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap1, characterized by possession of the Ras/Rap-associating domains and implicated in the etiology of schizophrenia. We previously found that dorsal telencephalon-specific Rapgef2 conditional knockout mice exhibits severe defects in formation of apical surface adherence junctions (AJs) and localization of radial glial cells (RGCs). In this study, we analyze the underlying molecular mechanism by using primary cultures of RGCs established from the developing cerebral cortex. The results show that Rapgef2-deficient RGCs exhibit a decreased ability of neurosphere formation, morphological changes represented by regression of radial glial (RG) fibers and reduced expression of AJ-constituent proteins such as N-cadherin, zonula occludens-1, E-cadherin and β-catenin. Moreover, siRNA-mediated knockdown of Rapgef2 or Rap1A inhibits the AJ protein expression and RG fiber formation while overexpression of Rapgef2, Rapgef6, Rap1AG12V or Rap1BG12V in Rapgef2-deficient RGCs restores them. Furthermore, Rapgef2-deficient RGCs exhibit a reduction in phosphorylation of extracellular signal-regulated kinase (ERK) leading to downregulation of the expression of c-jun, which is implicated in the AJ protein expression. These results indicate a crucial role of the Rapgef2-Rap1A-ERK-c-jun pathway in regulation of the AJ formation in RGCs. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Ion exchange equilibrium constants

    CERN Document Server

    Marcus, Y


    Ion Exchange Equilibrium Constants focuses on the test-compilation of equilibrium constants for ion exchange reactions. The book first underscores the scope of the compilation, equilibrium constants, symbols used, and arrangement of the table. The manuscript then presents the table of equilibrium constants, including polystyrene sulfonate cation exchanger, polyacrylate cation exchanger, polymethacrylate cation exchanger, polysterene phosphate cation exchanger, and zirconium phosphate cation exchanger. The text highlights zirconium oxide anion exchanger, zeolite type 13Y cation exchanger, and

  8. Segmented heat exchanger (United States)

    Baldwin, Darryl Dean; Willi, Martin Leo; Fiveland, Scott Byron; Timmons, Kristine Ann


    A segmented heat exchanger system for transferring heat energy from an exhaust fluid to a working fluid. The heat exchanger system may include a first heat exchanger for receiving incoming working fluid and the exhaust fluid. The working fluid and exhaust fluid may travel through at least a portion of the first heat exchanger in a parallel flow configuration. In addition, the heat exchanger system may include a second heat exchanger for receiving working fluid from the first heat exchanger and exhaust fluid from a third heat exchanger. The working fluid and exhaust fluid may travel through at least a portion of the second heat exchanger in a counter flow configuration. Furthermore, the heat exchanger system may include a third heat exchanger for receiving working fluid from the second heat exchanger and exhaust fluid from the first heat exchanger. The working fluid and exhaust fluid may travel through at least a portion of the third heat exchanger in a parallel flow configuration.

  9. Totalization Data Exchange (TDEX) (United States)

    Social Security Administration — The Totalization Data Exchange (TDEX) process is an exchange between SSA and its foreign country partners to identify deaths of beneficiaries residing abroad. The...

  10. Developing Sociolinguistic Competence through Intercultural Online Exchange (United States)

    Ritchie, Mathy


    The main goal of this study was to investigate whether computer-mediated communication (CMC) intercultural exchange offers the conditions necessary for the development of the sociolinguistic competence of second language learners. Non-native speakers (NNS) of French in British Columbia interacted through CMC with native speakers (NS) of French in…

  11. The labeling of unsaturated gamma-hydroxybutyric acid by heavy isotopes of hydrogen: iridium complex-mediated H/D exchange by C-H bond activation vs reduction by boro-deuterides/tritides

    Czech Academy of Sciences Publication Activity Database

    Marek, Aleš; Pedersen, M. H. F.; Vogensen, S. B.; Clausen, R. P.; Frolund, B.; Elbert, Tomáš


    Roč. 59, č. 12 (2016), s. 476-483 ISSN 0362-4803 Institutional support: RVO:61388963 Keywords : C-H activation * borotritides * hydrogen/deuterium exchange * iridium catalyst * tritium-labeled gamma-hydroxybutyric acid Subject RIV: CC - Organic Chemistry Impact factor: 1.745, year: 2016

  12. Hexanedioic acid mediated surface-ligand-exchange process for transferring NaYF4:Yb/Er (or Yb/Tm) up-converting nanoparticles from hydrophobic to hydrophilic

    NARCIS (Netherlands)

    Zhang, Q.; Song, K.; Zhao, J.; Kong, X.; Sun, Y.; Liu, X.; Zhang, Y.; Zeng, Q.; Zhang, H.


    Water-soluble and carboxyl-functionalized up-converting rare-earth nanoparticles (UCNPs) are obtained via an efficient surface-ligand-exchange procedure. Hexanedioic acid molecules are employed to replace the original hydrophobic ligands in diethylene glycol solvent at high temperature. Various

  13. VT Telephone Exchange Boundaries (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The UtilityTelecom_EXCHANGE represents Vermont Telephone Exchange boundaries as defined by the VT Public Service Board. The original data was...

  14. Ideal Heat Exchange System (United States)

    Tsirlin, A. M.


    The requirements with which a heat exchange system should comply in order that at certain values of the total contact surface and heat load the entropy production in it should be minimal have been determined. It has been shown that this system can serve as a standard for real systems of irreversible heat exchange. We have found the conditions for physical realizability of a heat exchange system in which heat exchange occurs by a law linear with respect to the temperature difference between contacting flows. Analogous conditions are given without deriving for the case of heat exchange by the Fourier law.

  15. Resolution exchange simulation. (United States)

    Lyman, Edward; Ytreberg, F Marty; Zuckerman, Daniel M


    We extend replica-exchange simulation in two ways and apply our approaches to biomolecules. The first generalization permits exchange simulation between models of differing resolution--i.e., between detailed and coarse-grained models. Such "resolution exchange" can be applied to molecular systems or spin systems. The second extension is to "pseudoexchange" simulations, which require little CPU usage for most levels of the exchange ladder and also substantially reduce the need for overlap between levels. Pseudoexchanges can be used in either replica or resolution exchange simulations. We perform efficient, converged simulations of a 50-atom peptide to illustrate the new approaches.

  16. Roles of perceived exchange quality and organisational identification in predicting turnover intention


    Kumar, Manish; Singh, Shailendra


    This paper explores whether the perceived quality of the leader–member exchange and the general environment of exchange could predict turnover intention. It further examines the role of organisational identification as an explanatory variable mediating between exchange relationships and turnover intention. The authors used three-step hierarchical linear regressions on a data set collected in two time waves. The results supported the mediating role of organisational identification for the lead...

  17. Adaptively Compressed Exchange Operator

    CERN Document Server

    Lin, Lin


    The Fock exchange operator plays a central role in modern quantum chemistry. The large computational cost associated with the Fock exchange operator hinders Hartree-Fock calculations and Kohn-Sham density functional theory calculations with hybrid exchange-correlation functionals, even for systems consisting of hundreds of atoms. We develop the adaptively compressed exchange operator (ACE) formulation, which greatly reduces the computational cost associated with the Fock exchange operator without loss of accuracy. The ACE formulation does not depend on the size of the band gap, and thus can be applied to insulating, semiconducting as well as metallic systems. In an iterative framework for solving Hartree-Fock-like systems, the ACE formulation only requires moderate modification of the code, and can be potentially beneficial for all electronic structure software packages involving exchange calculations. Numerical results indicate that the ACE formulation can become advantageous even for small systems with tens...

  18. Power decreases trust in social exchange. (United States)

    Schilke, Oliver; Reimann, Martin; Cook, Karen S


    How does lacking vs. possessing power in a social exchange affect people's trust in their exchange partner? An answer to this question has broad implications for a number of exchange settings in which dependence plays an important role. Here, we report on a series of experiments in which we manipulated participants' power position in terms of structural dependence and observed their trust perceptions and behaviors. Over a variety of different experimental paradigms and measures, we find that more powerful actors place less trust in others than less powerful actors do. Our results contradict predictions by rational actor models, which assume that low-power individuals are able to anticipate that a more powerful exchange partner will place little value on the relationship with them, thus tends to behave opportunistically, and consequently cannot be trusted. Conversely, our results support predictions by motivated cognition theory, which posits that low-power individuals want their exchange partner to be trustworthy and then act according to that desire. Mediation analyses show that, consistent with the motivated cognition account, having low power increases individuals' hope and, in turn, their perceptions of their exchange partners' benevolence, which ultimately leads them to trust.

  19. Laser Processed Heat Exchangers (United States)

    Hansen, Scott


    The Laser Processed Heat Exchanger project will investigate the use of laser processed surfaces to reduce mass and volume in liquid/liquid heat exchangers as well as the replacement of the harmful and problematic coatings of the Condensing Heat Exchangers (CHX). For this project, two scale unit test articles will be designed, manufactured, and tested. These two units are a high efficiency liquid/liquid HX and a high reliability CHX.

  20. Microsoft Exchange 2013 cookbook

    CERN Document Server

    Van Horenbeeck, Michael


    This book is a practical, hands-on guide that provides the reader with a number of clear, step-by-step exercises.""Microsoft Exchange 2013 Cookbook"" is targeted at network administrators who deal with the Exchange server in their day-to-day jobs. It assumes you have some practical experience with previous versions of Exchange (although this is not a requirement), without being a subject matter expert.

  1. Microtube strip heat exchanger (United States)

    Doty, F. D.


    During the last quarter, Doty Scientific, Inc. (DSI) continued to make progress on the microtube strip (MTS) heat exchanger. The DSI completed a heat exchanger stress analysis of the ten-module heat exchanger bank; and performed a shell-side flow inhomogeneity analysis of the three-module heat exchanger bank. The company produced 50 tubestrips using an in-house CNC milling machine and began pressing them onto tube arrays. The DSI revised some of the tooling required to encapsulate a tube array and press tubestrips into the array to improve some of the prototype tooling.

  2. Roles of perceived exchange quality and organisational identification in predicting turnover intention

    Directory of Open Access Journals (Sweden)

    Manish Kumar


    Full Text Available This paper explores whether the perceived quality of the leader–member exchange and the general environment of exchange could predict turnover intention. It further examines the role of organisational identification as an explanatory variable mediating between exchange relationships and turnover intention. The authors used three-step hierarchical linear regressions on a data set collected in two time waves. The results supported the mediating role of organisational identification for the leader–member exchange and turnover intention relationship as well as the general environment of exchange and turnover intention relationship. Moreover, as was expected, the general exchange quality had a greater impact on organisational identification compared to the leader–member exchange quality. However, the findings did not confirm the expected trend in the case of two exchange variables predicting turnover intention.


    Directory of Open Access Journals (Sweden)



    Full Text Available The mediation contract – a contract by which conflicting parties agree, in conjunction with a mediator, upon conflict resolve in an amiable manner through the agency of mediation, under due efforts on the mediator’s part, in exchange for payment of a fee by the parties – must contain a set of mandatory clauses in compliance with legal provisions, Article 45 of Law no. 192/2006. In the absence of one of said clauses, sanction by absolute annulment is imposed.

  4. GRUNDTVIG in transnational exchange

    DEFF Research Database (Denmark)

    Grundtvig in transnational exchange is the report from the seminar in december 2015 in cooperation with University of Cape Town and University of Hamburg.......Grundtvig in transnational exchange is the report from the seminar in december 2015 in cooperation with University of Cape Town and University of Hamburg....

  5. Optimization of Heat Exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Ivan Catton


    The objective of this research is to develop tools to design and optimize heat exchangers (HE) and compact heat exchangers (CHE) for intermediate loop heat transport systems found in the very high temperature reator (VHTR) and other Generation IV designs by addressing heat transfer surface augmentation and conjugate modeling. To optimize heat exchanger, a fast running model must be created that will allow for multiple designs to be compared quickly. To model a heat exchanger, volume averaging theory, VAT, is used. VAT allows for the conservation of mass, momentum and energy to be solved for point by point in a 3 dimensional computer model of a heat exchanger. The end product of this project is a computer code that can predict an optimal configuration for a heat exchanger given only a few constraints (input fluids, size, cost, etc.). As VAT computer code can be used to model characteristics )pumping power, temperatures, and cost) of heat exchangers more quickly than traditional CFD or experiment, optimization of every geometric parameter simultaneously can be made. Using design of experiment, DOE and genetric algorithms, GE, to optimize the results of the computer code will improve heat exchanger disign.

  6. Education and Industry Exchange (United States)

    Webb, Gerald A.


    Through an exchange plan a school representative worked at the personnel counter of a local company, and a supervisor from that company worked with counselors, faculty, administrators, and students from the local school. The exchange of ideas and insights were of benefit to the school and the company. (KP)

  7. Heat exchanger design handbook

    CERN Document Server

    Thulukkanam, Kuppan


    Completely revised and updated to reflect current advances in heat exchanger technology, Heat Exchanger Design Handbook, Second Edition includes enhanced figures and thermal effectiveness charts, tables, new chapter, and additional topics--all while keeping the qualities that made the first edition a centerpiece of information for practicing engineers, research, engineers, academicians, designers, and manufacturers involved in heat exchange between two or more fluids.See What's New in the Second Edition: Updated information on pressure vessel codes, manufacturer's association standards A new c

  8. Anion exchange membrane (United States)

    Verkade, John G; Wadhwa, Kuldeep; Kong, Xueqian; Schmidt-Rohr, Klaus


    An anion exchange membrane and fuel cell incorporating the anion exchange membrane are detailed in which proazaphosphatrane and azaphosphatrane cations are covalently bonded to a sulfonated fluoropolymer support along with anionic counterions. A positive charge is dispersed in the aforementioned cations which are buried in the support to reduce the cation-anion interactions and increase the mobility of hydroxide ions, for example, across the membrane. The anion exchange membrane has the ability to operate at high temperatures and in highly alkaline environments with high conductivity and low resistance.

  9. Data Exchange Inventory System (DEXI) (United States)

    Social Security Administration — Enterprise tool used to identify data exchanges occurring between SSA and our trading partners. DEXI contains information on both incoming and outgoing exchanges and...

  10. Microplate Heat Exchanger Project (United States)

    National Aeronautics and Space Administration — We propose a microplate heat exchanger for cryogenic cooling systems used for continuous flow distributed cooling systems, large focal plane arrays, multiple cooling...

  11. Exchange Risk Management Policy

    CERN Document Server


    At the Finance Committee of March 2005, following a comment by the CERN Audit Committee, the Chairman invited the Management to prepare a document on exchange risk management policy. The Finance Committee is invited to take note of this document.

  12. HUD Exchange Grantee Database (United States)

    Department of Housing and Urban Development — The About Grantees section of the HUD Exchange brings up contact information, reports, award, jurisdiction, and location data for organizations that receive HUD...

  13. NASA Earth Exchange (NEX) (United States)

    National Aeronautics and Space Administration — The NASA Earth Exchange (NEX) represents a new platform for the Earth science community that provides a mechanism for scientific collaboration and knowledge sharing....

  14. Anion exchange polymer electrolytes (United States)

    Kim, Yu Seung; Kim, Dae Sik


    Anion exchange polymer electrolytes that include guanidinium functionalized polymers may be used as membranes and binders for electrocatalysts in preparation of anodes for electrochemical cells such as solid alkaline fuel cells.

  15. Resonant indirect exchange in 1D semiconductor nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Rozhansky, I.V., E-mail: [Ioffe Institute, Russian Academy of Sciences, St.Petersburg 194021 (Russian Federation); Lappeenranta University of Technology, P.O. Box 20, FI-53851 Lappeenranta (Finland); St. Petersburg State Polytechnic University, St. Petersburg 195251 (Russian Federation); Krainov, I.V.; Averkiev, N.S. [Ioffe Institute, Russian Academy of Sciences, St.Petersburg 194021 (Russian Federation); Lähderanta, E. [Lappeenranta University of Technology, P.O. Box 20, FI-53851 Lappeenranta (Finland)


    We consider resonant indirect exchange interaction between magnetic centers in 1D nanostructures. The magnetic centers are assumed to be coupled to the 1D conducting channel by the quantum tunneling which can be of resonant character. The indirect exchange between the centers is mediated by the free carriers of the channel. The two cases of quadratic and linear energy dispersion of the 1D free carriers are considered. The former case is attributed to conventional semiconductor (InGaAs based to be concrete) nanowires or nanowhiskers, while the latter case is associated with carbon nanotubes with magnetic adatoms. We demonstrate that whenever the energy of a bound state at the magnetic center lies within the continuum energy spectra of the delocalized carriers in the channel the indirect exchange is strongly enhanced due to effective tunnel hybridization of the bound states with the continuum. - Highlights: • A resonant indirect exchange interaction between magnetic centers mediated by a 1D conducting channel is considered. • It is shown that the indirect exchange is strongly enhanced due to resonant tunnel coupling of a magnetic bound state with the delocalized states. • The two cases of quadratic and linear energy dispersion of the 1D free carriers are considered. • Pecularities of the indirect exchange mediated by a carbon nanotube has been investigated.

  16. Cryptographic Combinatorial Securities Exchanges (United States)

    Thorpe, Christopher; Parkes, David C.

    We present a useful new mechanism that facilitates the atomic exchange of many large baskets of securities in a combinatorial exchange. Cryptography prevents information about the securities in the baskets from being exploited, enhancing trust. Our exchange offers institutions who wish to trade large positions a new alternative to existing methods of block trading: they can reduce transaction costs by taking advantage of other institutions’ available liquidity, while third party liquidity providers guarantee execution—preserving their desired portfolio composition at all times. In our exchange, institutions submit encrypted orders which are crossed, leaving a “remainder”. The exchange proves facts about the portfolio risk of this remainder to third party liquidity providers without revealing the securities in the remainder, the knowledge of which could also be exploited. The third parties learn either (depending on the setting) the portfolio risk parameters of the remainder itself, or how their own portfolio risk would change if they were to incorporate the remainder into a portfolio they submit. In one setting, these third parties submit bids on the commission, and the winner supplies necessary liquidity for the entire exchange to clear. This guaranteed clearing, coupled with external price discovery from the primary markets for the securities, sidesteps difficult combinatorial optimization problems. This latter method of proving how taking on the remainder would change risk parameters of one’s own portfolio, without revealing the remainder’s contents or its own risk parameters, is a useful protocol of independent interest.


    National Research Council Canada - National Science Library

    Jie Zhang; Yun Fan; Xu Zhang


    .... Drawing on a relational perspective, we conceptualized a moderated mediation model in which power motivation enhanced individual creativity through improving the quality of leader-member exchange (LMX...

  18. Exchanging Description Logic Knowledge Bases

    NARCIS (Netherlands)

    Arenas, M.; Botoeva, E.; Calvanese, D.; Ryzhikov, V.; Sherkhonov, E.


    In this paper, we study the problem of exchanging knowledge between a source and a target knowledge base (KB), connected through mappings. Differently from the traditional database exchange setting, which considers only the exchange of data, we are interested in exchanging implicit knowledge. As

  19. Mediatized Humanitarianism

    DEFF Research Database (Denmark)

    Vestergaard, Anne


    The article investigates the implications of mediatization for the legitimation strategies of humanitarian organizations. Based on a (full population) corpus of ~400 pages of brochure material from 1970 to 2007, the micro-textual processes involved in humanitarian organizations' efforts to legiti......The article investigates the implications of mediatization for the legitimation strategies of humanitarian organizations. Based on a (full population) corpus of ~400 pages of brochure material from 1970 to 2007, the micro-textual processes involved in humanitarian organizations' efforts...... legitimation by accountancy, legitimation by institutionalization, and legitimation by compensation. The analysis relates these changes to a problem of trust associated with mediatization through processes of mediation....

  20. Microgravity condensing heat exchanger (United States)

    Thomas, Christopher M. (Inventor); Ma, Yonghui (Inventor); North, Andrew (Inventor); Weislogel, Mark M. (Inventor)


    A heat exchanger having a plurality of heat exchanging aluminum fins with hydrophilic condensing surfaces which are stacked and clamped between two cold plates. The cold plates are aligned radially along a plane extending through the axis of a cylindrical duct and hold the stacked and clamped portions of the heat exchanging fins along the axis of the cylindrical duct. The fins extend outwardly from the clamped portions along approximately radial planes. The spacing between fins is symmetric about the cold plates, and are somewhat more closely spaced as the angle they make with the cold plates approaches Passageways extend through the fins between vertex spaces which provide capillary storage and communicate with passageways formed in the stacked and clamped portions of the fins, which communicate with water drains connected to a pump externally to the duct. Water with no entrained air is drawn from the capillary spaces.

  1. Ion exchange phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Bourg, I.C.; Sposito, G.


    Ion exchange phenomena involve the population of readily exchangeable ions, the subset of adsorbed solutes that balance the intrinsic surface charge and can be readily replaced by major background electrolyte ions (Sposito, 2008). These phenomena have occupied a central place in soil chemistry research since Way (1850) first showed that potassium uptake by soils resulted in the release of an equal quantity of moles of charge of calcium and magnesium. Ion exchange phenomena are now routinely modeled in studies of soil formation (White et al., 2005), soil reclamation (Kopittke et al., 2006), soil fertilitization (Agbenin and Yakubu, 2006), colloidal dispersion/flocculation (Charlet and Tournassat, 2005), the mechanics of argillaceous media (Gajo and Loret, 2007), aquitard pore water chemistry (Tournassat et al., 2008), and groundwater (Timms and Hendry, 2007; McNab et al., 2009) and contaminant hydrology (Chatterjee et al., 2008; van Oploo et al., 2008; Serrano et al., 2009).

  2. Heat exchanger panel (United States)

    Warburton, Robert E. (Inventor); Cuva, William J. (Inventor)


    The present invention relates to a heat exchanger panel which has broad utility in high temperature environments. The heat exchanger panel has a first panel, a second panel, and at least one fluid containment device positioned intermediate the first and second panels. At least one of the first panel and the second panel have at least one feature on an interior surface to accommodate the at least one fluid containment device. In a preferred embodiment, each of the first and second panels is formed from a high conductivity, high temperature composite material. Also, in a preferred embodiment, the first and second panels are joined together by one or more composite fasteners.

  3. Microscale Regenerative Heat Exchanger (United States)

    Moran, Matthew E.; Stelter, Stephan; Stelter, Manfred


    The device described herein is designed primarily for use as a regenerative heat exchanger in a miniature Stirling engine or Stirling-cycle heat pump. A regenerative heat exchanger (sometimes called, simply, a "regenerator" in the Stirling-engine art) is basically a thermal capacitor: Its role in the Stirling cycle is to alternately accept heat from, then deliver heat to, an oscillating flow of a working fluid between compression and expansion volumes, without introducing an excessive pressure drop. These volumes are at different temperatures, and conduction of heat between these volumes is undesirable because it reduces the energy-conversion efficiency of the Stirling cycle.

  4. Complex Mediation

    DEFF Research Database (Denmark)

    Bødker, Susanne; Andersen, Peter Bøgh


    This article has its starting point in a large number of empirical findings regarding computer-mediated work. These empirical findings have challenged our understanding of the role of mediation in such work; on the one hand as an aspect of communication and cooperation at work and on the other hand...... as an aspect of human engagement with instruments of work. On the basis of previous work in activity-theoretical and semiotic human—computer interaction, we propose a model to encompass both of these aspects. In a dialogue with our empirical findings we move on to propose a number of types of mediation...... that have helped to enrich our understanding of mediated work and the design of computer mediation for such work....

  5. Social Exchange in Dutch Schools for Vocational Education and Training (United States)

    Thomsen, Maren; Karsten, Sjoerd; Oort, Frans J.


    In this study we examined the role of trust as a mediator in social exchange between teachers and their school, particularly between perceived procedural justice and perceived organizational support, on the one hand, and teachers' affective organizational commitment and organizational citizenship behaviour, on the other hand. A model was developed…

  6. Host plant quality mediates competition between arbuscular mycorrhizal fungi

    NARCIS (Netherlands)

    Knegt, B.; Jansa, J.; Franken, O.; Engelmoer, D.J.P.; Werner, G.D.A.; Bücking, H.; Kiers, E.T.


    Arbuscular mycorrhizal fungi exchange soil nutrients for carbon from plant hosts. Empirical works suggests that hosts may selectively provide resources to different fungal species, ultimately affecting fungal competition. However, fungal competition may also be mediated by colonization strategies of

  7. Nature's Heat Exchangers. (United States)

    Barnes, George


    Discusses the heat-transfer systems of different animals. Systems include heat conduction into the ground, heat transferred by convection, heat exchange in lizards, fish and polar animals, the carotid rete system, electromagnetic radiation from animals and people, and plant and animal fiber optics. (MDH)

  8. Basic Exchange Rate Theories

    NARCIS (Netherlands)

    J.G.M. van Marrewijk (Charles)


    textabstractThis four-chapter overview of basic exchange rate theories discusses (i) the elasticity and absorption approach, (ii) the (long-run) implications of the monetary approach, (iii) the short-run effects of monetary and fiscal policy under various economic conditions, and (iv) the transition

  9. Technology Performance Exchange

    Energy Technology Data Exchange (ETDEWEB)


    To address the need for accessible, high-quality data, the Department of Energy has developed the Technology Performance Exchange (TPEx). TPEx enables technology suppliers, third-party testing laboratories, and other entities to share product performance data. These data are automatically transformed into a format that technology evaluators can easily use in their energy modeling assessments to inform procurement decisions.

  10. Telephone Exchange Maintenance

    CERN Document Server


    Urgent maintenance work on CERN telephone exchanges will be performed on 24 March from 6 a.m. to 8 a.m. Telephone services may be disrupted or even interrupted during this time. For more details, please contact us by email at

  11. Baltic Exchange toodi Tallinna

    Index Scriptorium Estoniae


    Viimane osa merekonteineritesse kokkupakitud Londoni laevandus- ja merebörsi Baltic Exchange'i endise peakorteri detailidest jõudis 2007. a. juunis Tallinna. Hoone detailid ostnud ärimehed Heiti Hääl ja Eerik-Niiles Kross plaanivad leida hoonele koha Tallinna kesklinnas. E.-N. Krossi kommentaar

  12. Heat exchanger. Varmeveksler

    Energy Technology Data Exchange (ETDEWEB)

    Rosman, I.E.; Wagner, W.R.


    The invention concerns a manifold for a plate-type heat exchanger, and includes a side channel connected the inlet of the manifold. The plates can be designed as an integral assembly together with the integrated side- and external end-manifolds as well. 16 drawings.

  13. Chemical exchange program analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Waffelaert, Pascale


    As part of its EMS, Sandia performs an annual environmental aspects/impacts analysis. The purpose of this analysis is to identify the environmental aspects associated with Sandia's activities, products, and services and the potential environmental impacts associated with those aspects. Division and environmental programs established objectives and targets based on the environmental aspects associated with their operations. In 2007 the most significant aspect identified was Hazardous Materials (Use and Storage). The objective for Hazardous Materials (Use and Storage) was to improve chemical handling, storage, and on-site movement of hazardous materials. One of the targets supporting this objective was to develop an effective chemical exchange program, making a business case for it in FY07, and fully implementing a comprehensive chemical exchange program in FY08. A Chemical Exchange Program (CEP) team was formed to implement this target. The team consists of representatives from the Chemical Information System (CIS), Pollution Prevention (P2), the HWMF, Procurement and the Environmental Management System (EMS). The CEP Team performed benchmarking and conducted a life-cycle analysis of the current management of chemicals at SNL/NM and compared it to Chemical Exchange alternatives. Those alternatives are as follows: (1) Revive the 'Virtual' Chemical Exchange Program; (2) Re-implement a 'Physical' Chemical Exchange Program using a Chemical Information System; and (3) Transition to a Chemical Management Services System. The analysis and benchmarking study shows that the present management of chemicals at SNL/NM is significantly disjointed and a life-cycle or 'Cradle-to-Grave' approach to chemical management is needed. This approach must consider the purchasing and maintenance costs as well as the cost of ultimate disposal of the chemicals and materials. A chemical exchange is needed as a mechanism to re-apply chemicals on site. This

  14. Counterflow Regolith Heat Exchanger (United States)

    Zubrin, Robert; Jonscher, Peter


    A problem exists in reducing the total heating power required to extract oxygen from lunar regolith. All such processes require heating a great deal of soil, and the heat energy is wasted if it cannot be recycled from processed material back into new material. The counterflow regolith heat exchanger (CoRHE) is a device that transfers heat from hot regolith to cold regolith. The CoRHE is essentially a tube-in-tube heat exchanger with internal and external augers attached to the inner rotating tube to move the regolith. Hot regolith in the outer tube is moved in one direction by a right-hand - ed auger, and the cool regolith in the inner tube is moved in the opposite direction by a left-handed auger attached to the inside of the rotating tube. In this counterflow arrangement, a large fraction of the heat from the expended regolith is transferred to the new regolith. The spent regolith leaves the heat exchanger close to the temperature of the cold new regolith, and the new regolith is pre-heated close to the initial temperature of the spent regolith. Using the CoRHE can reduce the heating requirement of a lunar ISRU system by 80%, reducing the total power consumption by a factor of two. The unique feature of this system is that it allows for counterflow heat exchange to occur between solids, instead of liquids or gases, as is commonly done. In addition, in variants of this concept, the hydrogen reduction can be made to occur within the counterflow heat exchanger itself, enabling a simplified lunar ISRU (in situ resource utilization) system with excellent energy economy and continuous nonbatch mode operation.

  15. Analytical applications of ion exchangers

    CERN Document Server

    Inczédy, J


    Analytical Applications of Ion Exchangers presents the laboratory use of ion-exchange resins. This book discusses the development in the analytical application of ion exchangers. Organized into 10 chapters, this book begins with an overview of the history and significance of ion exchangers for technical purposes. This text then describes the properties of ion exchangers, which are large molecular water-insoluble polyelectrolytes having a cross-linked structure that contains ionic groups. Other chapters consider the theories concerning the operation of ion-exchange resins and investigate th

  16. Data Exchange Inventory (DEXI) System (United States)

    Social Security Administration — DEXI is an intranet application used by SSA users to track all incoming and outgoing data exchanges between SSA and our data exchange partners. Information such as...

  17. Dynamical Clustering of Exchange Rates


    Fenn, Daniel J.; Porter, Mason A.; Mucha, Peter J; Mark McDonald; Stacy Williams; Johnson, Neil F.; Jones, Nick S


    We use techniques from network science to study correlations in the foreign exchange (FX) market over the period 1991--2008. We consider an FX market network in which each node represents an exchange rate and each weighted edge represents a time-dependent correlation between the rates. To provide insights into the clustering of the exchange rate time series, we investigate dynamic communities in the network. We show that there is a relationship between an exchange rate's functional role withi...

  18. Serial tempering without exchange. (United States)

    Nymeyer, Hugh


    Serial tempering is a computational method that turns the temperature T (or more generally any independent λ parameter) into a dynamical variable. It is shown that, under conditions for which this variable is fast, serial tempering is equivalent to the umbrella sampling method with a single effective potential. This equivalence is demonstrated using both a small one-dimensional system and a small solvated peptide. The suggestion is then made to replace the serial tempering protocol with the equivalent umbrella sampling calculation. This approach, serial tempering without exchange (STeWiE), has the same performance as serial tempering in the limit that exchanges are frequent, is simpler to implement, and has fewer adjustable parameters than conventional serial tempering. The equivalence of serial tempering and STeWiE also provides a convenient route for estimating and optimizing the performance of serial tempering simulations and other generalized-ensemble methods.

  19. Lipid exchange by ultracentrifugation

    DEFF Research Database (Denmark)

    Drachmann, Nikolaj Düring; Olesen, Claus


    Lipids play an important role in maintaining P-type ATPase structure and function, and often they are crucial for ATPase activity. When the P-type ATPases are in the membrane, they are surrounded by a mix of different lipids species with varying aliphatic chain lengths and saturation......, and the complex interplay between the lipids and the P-type ATPases are still not well understood. We here describe a robust method to exchange the majority of the lipids surrounding the ATPase after solubilisation and/or purification with a target lipid of interest. The method is based on an ultracentrifugation...... step, where the protein sample is spun through a dense buffer containing large excess of the target lipid, which results in an approximately 80-85 % lipid exchange. The method is a very gently technique that maintains protein folding during the process, hence allowing further characterization...

  20. Exchange rate rebounds after foreign exchange market interventions (United States)

    Hoshikawa, Takeshi


    This study examined the rebounds in the exchange rate after foreign exchange intervention. When intervention is strongly effective, the exchange rate rebounds at next day. The effect of intervention is reduced slightly by the rebound after the intervention. The exchange rate might have been 67.12-77.47 yen to a US dollar without yen-selling/dollar-purchasing intervention of 74,691,100 million yen implemented by the Japanese government since 1991, in comparison to the actual exchange rate was 103.19 yen to the US dollar at the end of March 2014.

  1. O3 and NOx Exchange

    NARCIS (Netherlands)

    Loubet, B.; Castell, J.F.; Laville, P.; Personne, E.; Tuzet, A.; Ammann, C.; Emberson, L.; Ganzeveld, L.; Kowalski, A.S.; Merbold, L.; Stella, P.; Tuovinen, J.P.


    This discussion was based on the background document “Review on modelling atmosphere-biosphere exchange of Ozone and Nitrogen oxides”, which reviews the processes contributing to biosphere-atmosphere exchange of O3 and NOx, including stomatal and non-stomatal exchange of O3 and NO, NO2.

  2. The stability of exchange networks

    NARCIS (Netherlands)

    Doğan, G.; Assen, M. van; Rijt, A. van de; Buskens, V.W.


    Economic and sociological exchange theories predict divisions of exchange benefits given an assumed fixed network of exchange relations. Since network structure has been found to have a large impact on actors’ payoffs, actors have strong incentives for network change.Weanswer the question what

  3. Integrated foreign exchange risk management

    DEFF Research Database (Denmark)

    Aabo, Tom; Høg, Esben; Kuhn, Jochen


    Empirical research has focused on export as a proxy for exchange rate exposure and the use of foreign exchange derivatives as an instrument to deal with this exposure. This empirical study applies an integrated foreign exchange risk management approach with a particular focus on the role of impor...

  4. Integrated Foreign Exchange Risk Management

    DEFF Research Database (Denmark)

    Aabo, Tom; Høg, Esben; Kuhn, Jochen

    Empirical research has focused on export as a proxy for the exchange rate exposure and the use of foreign exchange derivatives as the instrument to deal with this exposure. This empirical study applies an integrated foreign exchange risk management approach with a particular focus on the role...

  5. Scraped surface heat exchangers. (United States)

    Rao, Chetan S; Hartel, Richard W


    Scraped surface heat exchangers (SSHEs) are commonly used in the food, chemical, and pharmaceutical industries for heat transfer, crystallization, and other continuous processes. They are ideally suited for products that are viscous, sticky, that contain particulate matter, or that need some degree of crystallization. Since these characteristics describe a vast majority of processed foods, SSHEs are especially suited for pumpable food products. During operation, the product is brought in contact with a heat transfer surface that is rapidly and continuously scraped, thereby exposing the surface to the passage of untreated product. In addition to maintaining high and uniform heat exchange, the scraper blades also provide simultaneous mixing and agitation. Heat exchange for sticky and viscous foods such as heavy salad dressings, margarine, chocolate, peanut butter, fondant, ice cream, and shortenings is possible only by using SSHEs. High heat transfer coefficients are achieved because the boundary layer is continuously replaced by fresh material. Moreover, the product is in contact with the heating surface for only a few seconds and high temperature gradients can be used without the danger of causing undesirable reactions. SSHEs are versatile in the use of heat transfer medium and the various unit operations that can be carried out simultaneously. This article critically reviews the current understanding of the operations and applications of SSHEs.

  6. Timing Foreign Exchange Markets

    Directory of Open Access Journals (Sweden)

    Samuel W. Malone


    Full Text Available To improve short-horizon exchange rate forecasts, we employ foreign exchange market risk factors as fundamentals, and Bayesian treed Gaussian process (BTGP models to handle non-linear, time-varying relationships between these fundamentals and exchange rates. Forecasts from the BTGP model conditional on the carry and dollar factors dominate random walk forecasts on accuracy and economic criteria in the Meese-Rogoff setting. Superior market timing ability for large moves, more than directional accuracy, drives the BTGP’s success. We explain how, through a model averaging Monte Carlo scheme, the BTGP is able to simultaneously exploit smoothness and rough breaks in between-variable dynamics. Either feature in isolation is unable to consistently outperform benchmarks throughout the full span of time in our forecasting exercises. Trading strategies based on ex ante BTGP forecasts deliver the highest out-of-sample risk-adjusted returns for the median currency, as well as for both predictable, traded risk factors.

  7. Paste heat exchange

    Energy Technology Data Exchange (ETDEWEB)


    The subject of coal paste heat exchangers is discussed in this letter report from Gelsenberg A.G. to I.G. Farbenindustrie A.G. Gelsenberg had given little consideration to the heating of coal paste by means of regeneration (heat exchange) because of the lack of experience in paste regeneration with bituminous coal, especially at 700 atmospheres. At the I.G. Farben plant at Poelitz, paste regeneration was carried out so that low concentration coal paste was heated in the regenerator together with the process gas, and the remaining coal was fed into the cold pass of the preheater in a thicker paste. Later tests proved this process viable. Gelsenberg heated normal coal paste and the gas in heat exchangers with the goal of relieving the preheater. Good results were achieved without change in design. The coal paste was heated with process gas in the regenerator at up to 315 degrees with constant pressure difference, so that after three months no decrease in K-values and no deposition or thickening was observed. Through the omission of paste gas, the pressure difference of the system became more constant and did not rise above the former level. The temperature also was more controllable, the chamber smoother running. Principal thermal data are given in a table. 1 table, 1 graph.

  8. The exchangeability of shape

    Directory of Open Access Journals (Sweden)

    Kaba Dramane


    Full Text Available Abstract Background Landmark based geometric morphometrics (GM allows the quantitative comparison of organismal shapes. When applied to systematics, it is able to score shape changes which often are undetectable by traditional morphological studies and even by classical morphometric approaches. It has thus become a fast and low cost candidate to identify cryptic species. Due to inherent mathematical properties, shape variables derived from one set of coordinates cannot be compared with shape variables derived from another set. Raw coordinates which produce these shape variables could be used for data exchange, however they contain measurement error. The latter may represent a significant obstacle when the objective is to distinguish very similar species. Results We show here that a single user derived dataset produces much less classification error than a multiple one. The question then becomes how to circumvent the lack of exchangeability of shape variables while preserving a single user dataset. A solution to this question could lead to the creation of a relatively fast and inexpensive systematic tool adapted for the recognition of cryptic species. Conclusions To preserve both exchangeability of shape and a single user derived dataset, our suggestion is to create a free access bank of reference images from which one can produce raw coordinates and use them for comparison with external specimens. Thus, we propose an alternative geometric descriptive system that separates 2-D data gathering and analyzes.

  9. Conceptual mediation: A new perspective on conceptual exchange (United States)

    Dawson, Chris; Lyndon, Harry


    For the last two decades science education researchers have had a major interest in identifying students’ intuitive understanding of a wide range of scientific topics and in reducing the difficulties involved when an attempt is made to replace these views by scientific understanding. Different approaches to this latter problem have been adopted by researchers, with strategies ranging from the pragmatic and atheoretical to those with a stronger theoretical foundation, usually based on some form of constructivism. In this paper we report on a novel theoretical perspective which takes as its foundation the psychological research of about three decades ago which investigated “forgetting,” and the important effects of previous knowledge in this process. In particular this new perspective demonstrates that, under normal teaching conditions, and through the process of proactive inhibition, the student’s prior knowledge can accelerate the forgetting of the newly taught scientific ideas. The paper first develops the theoretical position and then shows that a change in teaching approach can take advantage of the differences between the students’ prior understanding and the scientific view to ensure more efficient replacement. Following this an overview of the new methodology, as it is currently being used on a trial basis by science teachers in South Australia, is briefly introduced.

  10. Mediatized play

    DEFF Research Database (Denmark)

    Johansen, Stine Liv

    Children’s play must nowadays be understood as a mediatized field in society and culture. Media – understood in a very broad sense - holds severe explanatory power in describing and understanding the practice of play, since play happens both with, through and inspired by media of different sorts........ In this presentation the case of ‘playing soccer’ will be outlined through its different mediated manifestations, including soccer games and programs on TV, computer games, magazines, books, YouTube videos and soccer trading cards....

  11. Mediating Business

    DEFF Research Database (Denmark)

    and globally. The book explores the history of key innovations and innovators in the business press. It analyzes changes in the discourse of business journalism associated with the growth in business news and the development of new ways of framing business issues and events. Finally, it examines......"Mediating Business" is a study of the expansion of business journalism. Building on evidence from Denmark, Finland, Norway and Sweden, "Mediating Business" is a comparative and multidisciplinary study of one of the major transformations of the mass media and the realm of business - nationally...... the organizational implications of the increased media visibility of business and, in particular, the development of corporate governance and media relations....

  12. The Dynamics of Multilateral Exchange (United States)

    Hausken, Kjell; Moxnes, John F.

    The article formulates a dynamic mathematical model where arbitrarily many players produce, consume, exchange, loan, and deposit arbitrarily many goods over time to maximize utility. Consuming goods constitutes a benefit, and producing, exporting, and loaning away goods constitute a cost. Utilities are benefits minus costs, which depend on the exchange ratios and bargaining functions. Three-way exchange occurs when one player acquires, through exchange, one good from another player with the sole purpose of using this good to exchange against the desired good from a third player. Such a triple handshake is not merely a set of double handshakes since the player assigns no interest to the first good in his benefit function. Cognitive and organization costs increase dramatically for higher order exchanges. An exchange theory accounting for media of exchange follows from simple generalization of two-way exchange. The examples of r-way exchange are the triangle trade between Africa, the USA, and England in the 17th and 18th centuries, the hypothetical hypercycle involving RNAs as players and enzymes as goods, and reaction-diffusion processes. The emergence of exchange, and the role of trading agents are discussed. We simulate an example where two-way exchange gives zero production and zero utility, while three-way exchange causes considerable production and positive utility. Maximum utility for each player is reached when exchanges of the same order as the number of players in society are allowed. The article merges micro theory and macro theory within the social, natural, and physical sciences.

  13. Cryogenic regenerative heat exchangers

    CERN Document Server

    Ackermann, Robert A


    An in-depth survey of regenerative heat exchangers, this book chronicles the development and recent commercialization of regenerative devices for cryogenic applications. Chapters cover historical background, concepts, practical applications, design data, and numerical solutions, providing the latest information for engineers to develop advanced cryogenic machines. The discussions include insights into the operation of a regenerator; descriptions of the cyclic and fluid temperature distributions in a regenerator; data for various matrix geometries and materials, including coarse and fine bronze, stainless steel-woven wire mesh screens, and lead spheres; and unique operating features of cryocoolers that produce deviations from ideal regenerator theory.

  14. Developing bulk exchange spring magnets

    Energy Technology Data Exchange (ETDEWEB)

    Mccall, Scott K.; Kuntz, Joshua D.


    A method of making a bulk exchange spring magnet by providing a magnetically soft material, providing a hard magnetic material, and producing a composite of said magnetically soft material and said hard magnetic material to make the bulk exchange spring magnet. The step of producing a composite of magnetically soft material and hard magnetic material is accomplished by electrophoretic deposition of the magnetically soft material and the hard magnetic material to make the bulk exchange spring magnet.

  15. Characteristics of model heat exchanger (United States)

    Kolínský, Jan


    The aim of this paper is thermal analysis of model water to water heat exchanger at different mass flow rates. Experimental study deals with determination of total heat transfer - power of the heat exchanger. Furthermore the paper deals with analysis of heat exchanger charakcteristic using a definition of thermal efficiency. It is demonstrated that it is advisable to monitor the dependence of thermal efficiency and flow ratio.

  16. What Drives Stock Exchange Integration?

    National Research Council Canada - National Science Library

    Ekaterina Dorodnykh


    .... After a broad discussion of the existent literature, the investigation combines a large number of potentially relevant determinants for the explanation of whether stock exchanges are participating...

  17. Mastering Microsoft Exchange Server 2013

    CERN Document Server

    Elfassy, David


    The bestselling guide to Exchange Server, fully updated for the newest version Microsoft Exchange Server 2013 is touted as a solution for lowering the total cost of ownership, whether deployed on-premises or in the cloud. Like the earlier editions, this comprehensive guide covers every aspect of installing, configuring, and managing this multifaceted collaboration system. It offers Windows systems administrators and consultants a complete tutorial and reference, ideal for anyone installing Exchange Server for the first time or those migrating from an earlier Exchange Server version.Microsoft

  18. Hybrid Heat Exchangers (United States)

    Tu, Jianping Gene; Shih, Wei


    A hybrid light-weight heat exchanger concept has been developed that uses high-conductivity carbon-carbon (C-C) composites as the heat-transfer fins and uses conventional high-temperature metals, such as Inconel, nickel, and titanium as the parting sheets to meet leakage and structural requirements. In order to maximize thermal conductivity, the majority of carbon fiber is aligned in the fin direction resulting in 300 W/m.K or higher conductivity in the fin directions. As a result of this fiber orientation, the coefficient of thermal expansion (CTE) of the C-C composite in both non-fiber directions matches well with the CTE of various high-temperature metal alloys. This allows the joining of fins and parting sheets by using high-temperature braze alloys.

  19. The Radioecology Exchange

    Energy Technology Data Exchange (ETDEWEB)

    Barnett, Catherine L.; Beresford, Nicholas A.; Patel, Sabera; Wells, Claire; Howard, Brenda J. [NERC Centre for Ecology and Hydrology, CEH Lancaster, Lancaster Environment Centre, Library Av., Bailrigg, Lancaster, LA1 4AP (United Kingdom); Mora, Juan Carlos; Real, Almudena [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Avenida complutense 22, Madrid, 28040 (Spain); Beaugelin-Seiller, Karine; Gilbin, Rodolphe; Hinton, Thomas [IRSN-Institut de Radioprotection et de Surete Nucleaire, 31, Avenue de la Division Leclerc, 92260 Fontenay-Aux-Roses (France); Vesterbacka, Pia; Muikku, Maarit; Outola, Iisa [Radiation and Nuclear Safety Authority, P.O. Box 14, FI-00881 Helsinki (Finland); Skuterud, Lavrans; AlbumYtre-Eide, Martin [Norwegian Radiation Protection Authority, Grini Naeringspark 13, Oesteraas, 1332 (Norway); Bradshaw, Clare; Stark, Karolina; Jaeschke, Ben [Stockholms Universitet, Universitetsvaegen 10, Stockholm, 10691 (Sweden); Oughton, Deborah; Skipperud, Lindis [NMBU Norwegian University of Life Science P.O. Box 5003N-1432 Aas, Oslo (Norway); Vandenhove, Hildegarde; Vanhoudt, Nathalie [SCK.CEN, Studiecentrum voor Kernenergie/Centre d' Etude de l' Energie Nucleaire, Avenue Herrmann-Debroux 40, BE-1160 Brussels (Belgium); Willrodt, Christine; Steiner, Martin [Bundesamt fuer Strahlenschutz, Willy-Brandt-Strasse 5, 38226 Salzgitter (Germany)


    The Radioecology Exchange ( was created in 2011 under the EU FP7 STAR (Strategy for Allied Radioecology) network of excellence. The project aims to integrate the research efforts on radioecology of nine European organisations into a sustainable network. The web site (together with associated Twitter feeds and Facebook page) currently provides the gateway to project outputs and other on-line radiation protection and radioecological resources. In 2013, the EU FP7 COMET (Coordination and implementation of a pan-European instrument for radioecology) project commenced; it aims to strengthen research on the impact of radiation on man and the environment. COMET includes the STAR partners with the addition of one Japanese and two Ukrainian research institutes. As STAR and COMET interact closely together and with the European Radioecology Alliance (, the Radioecology Exchange will be modified to become an international 'hub' for information related to radioecology. Project specific information will be hosted on separate web sites and This paper will present an overview of the resources hosted on the Radioecology Exchange inviting other scientists to contribute. Highlighted aspects of the site include: Social media (News blog, Twitter, Facebook) - Items announcing project outputs, training courses, jobs, studentships etc. Virtual laboratory - Information which encourages integration through joint research and integrated use of data and sample materials. These pages will focus on three categories: (1) Methodological: descriptions and video clips of commonly used analytical methods and protocols and the procedures used in STAR and COMET; (2) Informative: databases made available by STAR/COMET partners together with details of sample archives held. Fact-sheets on radio-ecologically important radionuclides and 'topical descriptions' which show absorbed

  20. 78 FR 69910 - Joint Industry Plan; BATS Exchange, Inc., BATS-Y Exchange, Inc., BOX Options Exchange LLC, C2... (United States)


    ... COMMISSION Joint Industry Plan; BATS Exchange, Inc., BATS-Y Exchange, Inc., BOX Options Exchange LLC, C2... LLC, NYSE Arca, Inc. and Topaz Exchange, LLC; Notice of Filing of Proposed National Market System Plan... and Exchange Commission (``Commission'') the proposed National Market System (``NMS'') Plan Governing...

  1. Liquid/liquid heat exchanger (United States)

    Miller, C. G.


    Conceptual design for heat exchanger, utilizing two immiscible liquids with dissimilar specific gravities in direct contact, is more efficient mechanism of heat transfer than conventional heat exchangers with walls or membranes. Concept could be adapted for collection of heat from solar or geothermal sources.

  2. Educators Exchange: A Program Evaluation. (United States)

    Armstrong, William B.

    The Educators Exchange Program (EEP) was established under a training and educational exchange agreement reached by California's San Diego Community College District (SDCCD) and the republic of Mexico. In the program, the District provided a 4-week technological training program to faculty at Centros de Capacitacion Tecnologica Industrial…

  3. Risk Balance in Exchange Protocols

    NARCIS (Netherlands)

    M.T. Dashti (Mohammad); Y. Wang (Yanjing); I. Cervesato


    htmlabstractWe study the behaviour of rational agents in exchange protocols which rely on trustees. We allow malicious parties to compromise the trustee by paying a cost and, thereby, present a game analysis that advocates exchange protocols which induce balanced risks on the participants. We also

  4. Professional Exchange: Mapping the Future. (United States)

    Dingman, Robert L.


    New associate editor of Professional Exchange section of "Journal of Mental Health Counseling" discusses importance of section. Lists potential topics suggested in 1989, then adds several other topics to the list. Concludes with guidelines for submission to Professional Exchange section. (NB)

  5. Heat exchanger leakage problem location

    Directory of Open Access Journals (Sweden)

    Jícha Miroslav


    Full Text Available Recent compact heat exchangers are very often assembled from numerous parts joined together to separate heat transfer fluids and to form the required heat exchanger arrangement. Therefore, the leak tightness is very important property of the compact heat exchangers. Although, the compact heat exchangers have been produced for many years, there are still technological problems associated with manufacturing of the ideal connection between the individual parts, mainly encountered with special purpose heat exchangers, e.g. gas turbine recuperators. This paper describes a procedure used to identify the leakage location inside the prime surface gas turbine recuperator. For this purpose, an analytical model of the leaky gas turbine recuperator was created to assess its performance. The results obtained are compared with the experimental data which were acquired during the recuperator thermal performance analysis. The differences between these two data sets are used to indicate possible leakage areas.

  6. Transendothelial lipoprotein exchange and microalbuminuria

    DEFF Research Database (Denmark)

    Jensen, Jan Skov; Feldt-Rasmussen, Bo; Jensen, Kurt Svarre


    OBJECTIVE: Microalbuminuria associates with increased risk of atherosclerosis in individuals without diabetes. We hypothesized that transendothelial lipoprotein exchange is elevated among such individuals, possibly explaining increased intimal lipoprotein accumulation and thus atherosclerosis....... METHODS: Using an in vivo isotope technique, transendothelial exchange of low density lipoprotein (LDL) was measured in 77 non-diabetic individuals. Autologous 131-iodinated LDL was reinjected intravenously, and the 1-h fractional escape rate was calculated as index of transendothelial exchange. RESULTS......: There was no difference in transendothelial LDL exchange between subjects with microalbuminuria versus normoalbuminuria (mean (95% confidence interval) 3.8%/h (3.3-4.3%/h) versus 4.2%/h (3.7-4.7%/h); P=0.33). In contrast, there was a positive correlation between transendothelial LDL exchange and (logarithmically...

  7. Next Generation Microchannel Heat Exchangers

    CERN Document Server

    Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin


    In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

  8. High Temperature Heat Exchanger Project

    Energy Technology Data Exchange (ETDEWEB)

    Anthony E. Hechanova, Ph.D.


    The UNLV Research Foundation assembled a research consortium for high temperature heat exchanger design and materials compatibility and performance comprised of university and private industry partners under the auspices of the US DOE-NE Nuclear Hydrogen Initiative in October 2003. The objectives of the consortium were to conduct investigations of candidate materials for high temperature heat exchanger componets in hydrogen production processes and design and perform prototypical testing of heat exchangers. The initial research of the consortium focused on the intermediate heat exchanger (located between the nuclear reactor and hydrogen production plan) and the components for the hydrogen iodine decomposition process and sulfuric acid decomposition process. These heat exchanger components were deemed the most challenging from a materials performance and compatibility perspective

  9. Fault-Tolerant Heat Exchanger (United States)

    Izenson, Michael G.; Crowley, Christopher J.


    A compact, lightweight heat exchanger has been designed to be fault-tolerant in the sense that a single-point leak would not cause mixing of heat-transfer fluids. This particular heat exchanger is intended to be part of the temperature-regulation system for habitable modules of the International Space Station and to function with water and ammonia as the heat-transfer fluids. The basic fault-tolerant design is adaptable to other heat-transfer fluids and heat exchangers for applications in which mixing of heat-transfer fluids would pose toxic, explosive, or other hazards: Examples could include fuel/air heat exchangers for thermal management on aircraft, process heat exchangers in the cryogenic industry, and heat exchangers used in chemical processing. The reason this heat exchanger can tolerate a single-point leak is that the heat-transfer fluids are everywhere separated by a vented volume and at least two seals. The combination of fault tolerance, compactness, and light weight is implemented in a unique heat-exchanger core configuration: Each fluid passage is entirely surrounded by a vented region bridged by solid structures through which heat is conducted between the fluids. Precise, proprietary fabrication techniques make it possible to manufacture the vented regions and heat-conducting structures with very small dimensions to obtain a very large coefficient of heat transfer between the two fluids. A large heat-transfer coefficient favors compact design by making it possible to use a relatively small core for a given heat-transfer rate. Calculations and experiments have shown that in most respects, the fault-tolerant heat exchanger can be expected to equal or exceed the performance of the non-fault-tolerant heat exchanger that it is intended to supplant (see table). The only significant disadvantages are a slight weight penalty and a small decrease in the mass-specific heat transfer.

  10. Electrically switched ion exchange

    Energy Technology Data Exchange (ETDEWEB)

    Lilga, M.A. [Pacific Northwest National Lab., Richland, WA (United States); Schwartz, D.T.; Genders, D.


    A variety of waste types containing radioactive {sup 137}Cs are found throughout the DOE complex. These waste types include water in reactor cooling basins, radioactive high-level waste (HLW) in underground storage tanks, and groundwater. Safety and regulatory requirements and economics require the removal of radiocesium before these wastes can be permanently disposed of. Electrically Switched Ion Exchange (ESIX) is an approach for radioactive cesium separation that combines IX and electrochemistry to provide a selective, reversible, and economic separation method that also produces little or no secondary waste. In the ESIX process, an electroactive IX film is deposited electrochemically onto a high-surface area electrode, and ion uptake and elution are controlled directly by modulating the potential of the film. For cesium, the electroactive films under investigation are ferrocyanides, which are well known to have high selectivities for cesium in concentrated sodium solutions. When a cathode potential is applied to the film, Fe{sup +3} is reduced to the Fe{sup +2} state, and a cation must be intercalated into the film to maintain charge neutrality (i.e., Cs{sup +} is loaded). Conversely, if an anodic potential is applied, a cation must be released from the film (i.e., Cs{sup +} is unloaded). Therefore, to load the film with cesium, the film is simply reduced; to unload cesium, the film is oxidized.

  11. Effects and Implications for Adoption of Brokerage System in Korea's Foreign Exchange Market

    Directory of Open Access Journals (Sweden)

    Yunjong Wang


    Full Text Available Since January 1st 1999, the South Korean government has begun to establish the understructure of the foreign exchange market in order to achieve the liberalization of foreign exchange. As one of the plans, the trade of foreign exchange which was under the monopolized mediation of the capital medium of financial settlement center will be in the charge of several commercial brokers. In the developed countries, the foreign exchange & stock system and the liberalization of foreign exchange are both widely used in a flexible way. So it is predicted that the introduction of commercial foreign exchange & stock system will bring positive effect to the enhancement of the market efficiency and the function of price both in South Korean market and overseas market, the foster of competitive power of the domestic broker and the improvement of the understructure of domestic foreign exchange market. But more importantly is that the foreign exchange market must expand the scale of its participator, bring in various relevant foreign exchange products and develop the bond market which has a close relationship with the foreign exchange market for further development.

  12. Plasma exchange in progressive systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Mohammad Bagher Owlia


    Full Text Available Systemic sclerosis (SSc is an autoimmune systemic disease of unknown etiology. Present treatment modalities have limited impact on clinical/ laboratory outcomes. For the first time in our center, we used plasma exchange (PEx in a rather young woman with recent onset but progressive SSc. She is a 39-year-old woman with a recent history of skin stiffness, Raynaud’s phenomenon, nail fold capillary changes and newly diagnosis of SSc presented to us due to worsening her clinical symptoms even after initiation of routine remedies such as low dose oral prednisolone, Ca-channel blockers, azathioprine and pentoxyfylline. After obtaining written consent, interdisciplinary discussion with experts in this field and agreement we started a series of plasma exchange with FFP replacement for her. A dramatic clinical response was observed in respect to Raynaud’s phenomenon, skin stiffness, tendon rub after three sessions of PEx. Her modified Rodnan skin score (MRSS dropped from 36 (before commencement of therapy to 28 in day 4 and 18 in day 20 after 15 sessions of PEx. In conclusion PEx could significantly modify the course of SSc as observed in our case study. Elimination of culprit immune mediators/cytokines/autoantibodies could be the possible mechanism of action of PEx. 

  13. Mediation: The Technological Foundation of Modern Science

    Directory of Open Access Journals (Sweden)

    Costantino Thanos


    Full Text Available Modern science is increasingly data-intensive, multidisciplinary, and network-centric. There is an emerging consensus among the members of the academic research community that the practices of this new science paradigm should be congruent with “open science”. This entails that the bonanza of research data, the wide availability of algorithms, data tools, and data services produced by the members of the research community must be discoverable, understandable, and usable by overcoming all kinds of heterogeneity and logical inconsistencies. The main concept for coping with the many dimensions of heterogeneity and logical inconsistency is mediation. Mediation is achieved by mediators or brokers. These are software modules that exploit encoded knowledge about certain datasets, data services, and user needs in order to implement an intermediary service. A mediating environment is an environment that provides a core set of intermediary services. Mediation should be a distinct functionality of future research data infrastructures. This paper surveys the different levels of interoperability, i.e., exchangeability, compatibility, and usability, their properties and relationships, mediation concepts, functions, and intermediary services. The current interoperability landscape is also illustrated. Finally, the paper advocates the need for mediating environments to be supported by future research data infrastructures and envisions that one of the most important features of future research data infrastructures will be mediation software.

  14. Custom, contract, and kidney exchange. (United States)

    Healy, Kieran; Krawiec, Kimberly D


    In this Essay, we examine a case in which the organizational and logistical demands of a novel form of organ exchange (the nonsimultaneous, extended, altruistic donor (NEAD) chain) do not map cleanly onto standard cultural schemas for either market or gift exchange, resulting in sociological ambiguity and legal uncertainty. In some ways, a NEAD chain resembles a form of generalized exchange, an ancient and widespread instance of the norm of reciprocity that can be thought of simply as the obligation to “pay it forward” rather than the obligation to reciprocate directly with the original giver. At the same time, a NEAD chain resembles a string of promises and commitments to deliver something in exchange for some valuable consideration--that is, a series of contracts. Neither of these salient "social imaginaries" of exchange--gift giving or formal contract--perfectly meets the practical demands of the NEAD system. As a result, neither contract nor generalized exchange drives the practice of NEAD chains. Rather, the majority of actual exchanges still resemble a simpler form of exchange: direct, simultaneous exchange between parties with no time delay or opportunity to back out. If NEAD chains are to reach their full promise for large-scale, nonsimultaneous organ transfer, legal uncertainties and sociological ambiguities must be finessed, both in the practices of the coordinating agencies and in the minds of NEAD-chain participants. This might happen either through the further elaboration of gift-like language and practices, or through a creative use of the cultural form and motivational vocabulary, but not necessarily the legal and institutional machinery, of contract.

  15. Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle

    DEFF Research Database (Denmark)

    Grabon, Aby; Orłowski, Adam; Tripathi, Ashutosh


    . However, the details of the PITP-mediated lipid exchange cycle remain entirely obscure. Here, all-atom molecular dynamics simulations of the mammalian StART-like PtdIns/phosphatidylcholine (PtdCho) transfer protein PITPα, both on membrane bilayers and in solvated systems, informed downstream biochemical...... analyses that tested key aspects of the hypotheses generated by the molecular dynamics simulations. These studies provided five key insights into the PITPα lipid exchange cycle: (i) interaction of PITPα with the membrane is spontaneous and mediated by four specific protein substructures; (ii) the ability......Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cells. The defining feature of PITPs is their ability to exchange phosphatidylinositol (PtdIns) molecules between membranes, and this property is central to PITP-mediated regulation of lipid signaling...



    Podobeková, Veronika; Peráčková, Jana


    The article discusses utilization of heat from waste water in sewage. During the year, temperature of water in sewage ranges between 10 °C and 20 °C and the heat from sewage could be used for heating, cooling and hot water preparation in building. The heat is extracted through a transfer surface area of the heat exchanger into the heat pump, which is able to utilize the low–potential energy. Different design and types of the heat exchangers in sewage are dealt with: heat exchangers embedded i...

  17. Relational and XML Data Exchange

    CERN Document Server

    Arenas, Marcelo


    Data exchange is the problem of finding an instance of a target schema, given an instance of a source schema and a specification of the relationship between the source and the target. Such a target instance should correctly represent information from the source instance under the constraints imposed by the target schema, and it should allow one to evaluate queries on the target instance in a way that is semantically consistent with the source data. Data exchange is an old problem that re-emerged as an active research topic recently, due to the increased need for exchange of data in various for

  18. Heat exchanger using graphite foam (United States)

    Campagna, Michael Joseph; Callas, James John


    A heat exchanger is disclosed. The heat exchanger may have an inlet configured to receive a first fluid and an outlet configured to discharge the first fluid. The heat exchanger may further have at least one passageway configured to conduct the first fluid from the inlet to the outlet. The at least one passageway may be composed of a graphite foam and a layer of graphite material on the exterior of the graphite foam. The layer of graphite material may form at least a partial barrier between the first fluid and a second fluid external to the at least one passageway.

  19. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. (United States)

    Knauf, Felix; Mohebbi, Nilufar; Teichert, Carsten; Herold, Diana; Rogina, Blanka; Helfand, Stephen; Gollasch, Maik; Luft, Friedrich C; Aronson, Peter S


    A longevity gene called Indy (for 'I'm not dead yet'), with similarity to mammalian genes encoding sodium-dicarboxylate cotransporters, was identified in Drosophila melanogaster. Functional studies in Xenopus oocytes showed that INDY mediates the flux of dicarboxylates and citrate across the plasma membrane, but the specific transport mechanism mediated by INDY was not identified. To test whether INDY functions as an anion exchanger, we examined whether substrate efflux is stimulated by transportable substrates added to the external medium. Efflux of [14C]citrate from INDY-expressing oocytes was greatly accelerated by the addition of succinate to the external medium, indicating citrate-succinate exchange. The succinate-stimulated [14C]citrate efflux was sensitive to inhibition by DIDS (4,4'-di-isothiocyano-2,2'-disulphonic stilbene), as demonstrated previously for INDY-mediated succinate uptake. INDY-mediated efflux of [14C]citrate was also stimulated by external citrate and oxaloacetate, indicating citrate-citrate and citrate-oxaloacetate exchange. Similarly, efflux of [14C]succinate from INDY-expressing oocytes was stimulated by external citrate, alpha-oxoglutarate and fumarate, indicating succinate-citrate, succinate-alpha-oxoglutarate and succinate-fumarate exchange respectively. Conversely, when INDY-expressing Xenopus oocytes were loaded with succinate and citrate, [14C]succinate uptake was markedly stimulated, confirming succinate-succinate and succinate-citrate exchange. Exchange of internal anion for external citrate was markedly pH(o)-dependent, consistent with the concept that citrate is co-transported with a proton. Anion exchange was sodium-independent. We conclude that INDY functions as an exchanger of dicarboxylate and tricarboxylate Krebs-cycle intermediates. The effect of decreasing INDY activity, as in the long-lived Indy mutants, may be to alter energy metabolism in a manner that favours lifespan extension.

  20. Subjective trust, perceived risk and exchange performance in buyer-supplier relationships


    Emanuela Delbufalo


    This article offers some theoretical and empirical contributions to the literature on relational exchange by examining the nature of subjective trust and perceived risk in buyer-supplier relationships. The relational view represents the theoretical framework for the research. The study explores the theoretical proposition that subjective trust and perceived risk in buyer-supplier relationships impact on exchange performance through the mediating effects of four sources of relational rents: as...

  1. Pu Anion Exchange Process Intensification

    Energy Technology Data Exchange (ETDEWEB)

    Taylor-Pashow, K. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    This project seeks to improve the efficiency of the plutonium anion-exchange process for purifying Pu through the development of alternate ion-exchange media. The objective of the project in FY15 was to develop and test a porous foam monolith material that could serve as a replacement for the current anion-exchange resin, Reillex® HPQ, used at the Savannah River Site (SRS) for purifying Pu. The new material provides advantages in efficiency over the current resin by the elimination of diffusive mass transport through large granular resin beads. By replacing the large resin beads with a porous foam there is much more efficient contact between the Pu solution and the anion-exchange sites present on the material. Several samples of a polystyrene based foam grafted with poly(4-vinylpyridine) were prepared and the Pu sorption was tested in batch contact tests.

  2. Liquid droplet heat exchanger studies (United States)

    Bruckner, A. P.; Hedges, D. E.; Yungster, S.


    Recent analytical and experimental investigations of the liquid droplet heat exchanger (LDHX) concept for space power applications are described. The performance of the LDHX is compared to that of a conventional heat exchanger for heat rejection applications in a Brayton cycle, using the mass-specific heat exchanger effectiveness as a figure of merit. It is shown that the LDHX has an order of magnitude advantage over the conventional heat exchanger. Furthermore, significant improvement in cycle efficiency and power to mass ratio is possible. Two-phase flow experiments in a laboratory scale LDHX, using air and water as the two media, show very good agreement with the quasi-one-dimensional model used in the parametric studies.

  3. Estimating Foreign Exchange Reserve Adequacy

    Directory of Open Access Journals (Sweden)

    Abdul Hakim


    Full Text Available Accumulating foreign exchange reserves, despite their cost and their impacts on other macroeconomics variables, provides some benefits. This paper models such foreign exchange reserves. To measure the adequacy of foreign exchange reserves for import, it uses total reserves-to-import ratio (TRM. The chosen independent variables are gross domestic product growth, exchange rates, opportunity cost, and a dummy variable separating the pre and post 1997 Asian financial crisis. To estimate the risky TRM value, this paper uses conditional Value-at-Risk (VaR, with the help of Glosten-Jagannathan-Runkle (GJR model to estimate the conditional volatility. The results suggest that all independent variables significantly influence TRM. They also suggest that the short and long run volatilities are evident, with the additional evidence of asymmetric effects of negative and positive past shocks. The VaR, which are calculated assuming both normal and t distributions, provide similar results, namely violations in 2005 and 2008.

  4. VLER Health Exchange by Area (United States)

    Department of Veterans Affairs — “Connect Your Docs” through the Virtual Lifetime Electronic Record (VLER) Health Exchange program. This program gives VA and community health care providers secure...

  5. Counterflow Regolith Heat Exchanger Project (United States)

    National Aeronautics and Space Administration — The counterflow regolith heat exchanger (CoRHE) is a device that transfers heat from hot regolith to cold regolith. The CoRHE is essentially a tube-in-tube heat...

  6. International Prices and Exchange Rates


    Gopinath, Gita; Burstein, Ariel


    We survey the recent empirical and theoretical developments in the literature on the relation between prices and exchange rates. After updating some of the major findings in the empirical literature we present a simple framework to interpret this evidence. We review theoretical models that generate insensitivity of prices to exchange rate changes through variable markups, both under flexible prices and nominal rigidities, first in partial equilibrium and then in general equilibrium.

  7. Exchange rate determination in Vietnam


    Thai-Ha Le


    This study investigates the determinants of the exchange rate in Vietnam and suggests policy implications. Gregory-Hansen cointegration tests and generalised variance decomposition (VDC) analysis were applied to monthly data from July 2004 to December 2013. The model was built based on the three popular approaches to exchange rate determination, which are purchasing power parity (PPP) approach, balance of payment (BOP) approach, and monetary and portfolio approach. This study finds that the p...

  8. Shared Year Exchange in Nursing

    DEFF Research Database (Denmark)

    Vedsegaard, Helle Wendner; Wederkinck, Elisabeth


    Beskrivelse af Shared Year Exchange in Nursing, et udviklingsporjekt omhandlende udvikling, beskrivelse og implementering af et fælles studieår for sygeplejerskestuderende ved Metropol og La Trobe University Australien.......Beskrivelse af Shared Year Exchange in Nursing, et udviklingsporjekt omhandlende udvikling, beskrivelse og implementering af et fælles studieår for sygeplejerskestuderende ved Metropol og La Trobe University Australien....

  9. Are anxious workers less productive workers? It depends on the quality of social exchange. (United States)

    McCarthy, Julie M; Trougakos, John P; Cheng, Bonnie Hayden


    In this article, we draw from Conservation of Resources Theory to advance and test a framework which predicts that emotional exhaustion plays an explanatory role underlying the relation between workplace anxiety and job performance. Further, we draw from social exchange theories to predict that leader-member exchange and coworker exchange will mitigate the harmful effects of anxiety on job performance. Findings across a 3-wave study of police officers supported our model. Emotional exhaustion mediated the link between workplace anxiety and job performance, over and above the effect of cognitive interference. Further, coworker exchange mitigated the positive relation between anxiety and emotional exhaustion, while leader-member exchange mitigated the negative relation between emotional exhaustion and job performance. This study elucidates the effects of workplace anxiety on resource depletion via emotional exhaustion and highlights the value of drawing on social resources to offset the potentially harmful effects of workplace anxiety on job performance. (c) 2016 APA, all rights reserved).

  10. To trade or not to trade: The moderating role of vividness when exchanging gambles

    Directory of Open Access Journals (Sweden)

    Michal Maimaran


    Full Text Available Individuals are generally reluctant to trade goods---a phenomenon identified as the endowment effect. This paper focuses on consumers' puzzling reluctance to exchange gambles, and in particular lottery tickets with identical distribution (i.e., same odds of winning, and identifies the ticket's vividness as an important moderator. Three studies demonstrate that individuals are more willing to exchange less vivid lottery tickets (e.g., tickets concealed in envelopes, or tickets with an unknown number compared to more vivid tickets (e.g., tickets not concealed in envelopes, or tickets with a known number when offered an incentive to exchange. Moreover, this effect is mediated by anticipated regret, such that less regret is anticipated when exchanging less vivid tickets, thus increasing individuals' willingness to exchange tickets.

  11. Ethical leadership and followers' taking charge: trust in, and identification with, leader as mediators

    National Research Council Canada - National Science Library

    Lee, Kihyun


    .... Drawing on both social exchange theory and social identity theory, I examined the influence of ethical leadership on followers taking charge through the mediation of trust in leader and identification with leader...

  12. Continuum-mediated dark matter–baryon scattering

    CERN Document Server

    Katz, Andrey; Sajjad, Aqil


    Many models of dark matter scattering with baryons may be treated either as a simple contact interaction or as the exchange of a light mediator particle. We study an alternative, in which a continuum of light mediator states may be exchanged. This could arise, for instance, from coupling to a sector which is approximately conformal at the relevant momentum transfer scale. In the non-relativistic effective theory of dark matter-baryon scattering, which is useful for parametrizing direct detection signals, the effect of such continuum mediators is to multiply the amplitude by a function of the momentum transfer q, which in the simplest case is just a power law. We develop the basic framework and study two examples: the case where the mediator is a scalar operator coupling to the Higgs portal (which turns out to be highly constrained) and the case of an antisymmetric tensor operator ${\\cal O}_{\\mu \

  13. Hospital safety climate and safety behavior: A social exchange perspective. (United States)

    Ancarani, Alessandro; Di Mauro, Carmela; Giammanco, Maria D

    Safety climate is considered beneficial to the improvement of hospital safety outcomes. Nevertheless, the relations between two of its key constituents, namely those stemming from leader-subordinate relations and coworker support for safety, are still to be fully ascertained. This article uses the theoretical lens of Social Exchange Theory to study the joint impact of leader-member exchange in the safety sphere and coworker support for safety on safety-related behavior at the hospital ward level. Social exchange constructs are further related to the existence of a shame-/blame-free environment, seen as a potential antecedent of safety behavior. A cross-sectional study including 166 inpatients in hospital wards belonging to 10 public hospitals in Italy was undertaken to test the hypotheses developed. Hypothesized relations have been analyzed through a fully mediated multilevel structural equation model. This methodology allows studying behavior at the individual level, while keeping into account the heterogeneity among hospital specialties. Results suggest that the linkage between leader support for safety and individual safety behavior is mediated by coworker support on safety issues and by the creation of a shame-free environment. These findings call for the creation of a safety climate in which managerial efforts should be directed not only to the provision of new safety resources and the enforcement of safety rules but also to the encouragement of teamwork and freedom to report errors as ways to foster the capacity of the staff to communicate, share, and learn from each other.

  14. Fair Exchange in Strand Spaces

    Directory of Open Access Journals (Sweden)

    Joshua D. Guttman


    Full Text Available Many cryptographic protocols are intended to coordinate state changes among principals. Exchange protocols coordinate delivery of new values to the participants, e.g. additions to the set of values they possess. An exchange protocol is fair if it ensures that delivery of new values is balanced: If one participant obtains a new possession via the protocol, then all other participants will, too. Fair exchange requires progress assumptions, unlike some other protocol properties. The strand space model is a framework for design and verification of cryptographic protocols. A strand is a local behavior of a single principal in a single session of a protocol. A bundle is a partially ordered global execution built from protocol strands and adversary activities. The strand space model needs two additions for fair exchange protocols. First, we regard the state as a multiset of facts, and we allow strands to cause changes in this state via multiset rewriting. Second, progress assumptions stipulate that some channels are resilient-and guaranteed to deliver messages-and some principals are assumed not to stop at certain critical steps. This method leads to proofs of correctness that cleanly separate protocol properties, such as authentication and confidentiality, from invariants governing state evolution. G. Wang's recent fair exchange protocol illustrates the approach.

  15. Pu Anion Exchange Process Intensification

    Energy Technology Data Exchange (ETDEWEB)

    Taylor-Pashow, Kathryn M. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    This research is focused on improving the efficiency of the anion exchange process for purifying plutonium. While initially focused on plutonium, the technology could also be applied to other ion-exchange processes. Work in FY17 focused on the improvement and optimization of porous foam columns that were initially developed in FY16. These foam columns were surface functionalized with poly(4-vinylpyridine) (PVP) to provide the Pu specific anion-exchange sites. Two different polymerization methods were explored for maximizing the surface functionalization with the PVP. The open-celled polymeric foams have large open pores and large surface areas available for sorption. The fluid passes through the large open pores of this material, allowing convection to be the dominant mechanism by which mass transport takes place. These materials generally have very low densities, open-celled structures with high cell interconnectivity, small cell sizes, uniform cell size distributions, and high structural integrity. These porous foam columns provide advantages over the typical porous resin beads by eliminating the slow diffusion through resin beads, making the anion-exchange sites easily accessible on the foam surfaces. The best performing samples exceeded the Pu capacity of the commercially available resin, and also offered the advantage of sharper elution profiles, resulting in a more concentrated product, with less loss of material to the dilute heads and tails cuts. An alternate approach to improving the efficiency of this process was also explored through the development of a microchannel array system for performing the anion exchange.

  16. Electrically Switched Cesium Ion Exchange

    Energy Technology Data Exchange (ETDEWEB)

    JPH Sukamto; ML Lilga; RK Orth


    This report discusses the results of work to develop Electrically Switched Ion Exchange (ESIX) for separations of ions from waste streams relevant to DOE site clean-up. ESIX combines ion exchange and electrochemistry to provide a selective, reversible method for radionuclide separation that lowers costs and minimizes secondary waste generation typically associated with conventional ion exchange. In the ESIX process, an electroactive ion exchange film is deposited onto. a high surface area electrode, and ion uptake and elution are controlled directly by modulating the potential of the film. As a result, the production of secondary waste is minimized, since the large volumes of solution associated with elution, wash, and regeneration cycles typical of standard ion exchange are not needed for the ESIX process. The document is presented in two parts: Part I, the Summary Report, discusses the objectives of the project, describes the ESIX concept and the approach taken, and summarizes the major results; Part II, the Technology Description, provides a technical description of the experimental procedures and in-depth discussions on modeling, case studies, and cost comparisons between ESIX and currently used technologies.

  17. Pervaporation with ion exchange membranes

    Energy Technology Data Exchange (ETDEWEB)

    Boeddeker, K.W.; Wenzlaff, A.


    Sorption and pervaporation of aqueous-organic solvent systems (water-ethanol; water-carboxylic acids) with commercial ion exchange membranes are compared to obtain information on polymersolvent interaction vs. coupling. Close agreement between sorption selectivity and pervaporation selectivity indicates coupling. If pervaporation is less selective than sorption, polymer-solvent interaction overtakes coupling, the limit of de-coupling being phase separation within the sorbate as signaled by a sudden increase in permeability of the lesser interacting component. As long as sorption and pervaporation operate in parallel, favoring enrichment of the same component, coupling enhances the separation effect. If pervaporation counteracts sorption, coupling is detrimental to the separation effect. Potential applications include the dehydration of pre-concentrated water-ethanol using anion exchange membranes, and the enrichment of acetic acid from dilute aqueous solution by pervaporative removal of water through cation exchange membranes.

  18. Oscillating-Coolant Heat Exchanger (United States)

    Scotti, Stephen J.; Blosser, Max L.; Camarda, Charles J.


    Devices useful in situations in which heat pipes inadequate. Conceptual oscillating-coolant heat exchanger (OCHEX) transports heat from its hotter portions to cooler portions. Heat transported by oscillation of single-phase fluid, called primary coolant, in coolant passages. No time-averaged flow in tubes, so either heat removed from end reservoirs on every cycle or heat removed indirectly by cooling sides of channels with another coolant. Devices include leading-edge cooling devices in hypersonic aircraft and "frost-free" heat exchangers. Also used in any situation in which heat pipe used and in other situations in which heat pipes not usable.


    Directory of Open Access Journals (Sweden)



    Full Text Available The experience of recentyears showsthat it hasa fundamentalroleformation mechanismof the exchange rateinmacroeconomic stabilization. Global economiccrises, oil shockshave shownthe difficultyoffloatingsustainabilitybyparticipants in the system. EuropeanMonetary System, focused onconcertedfloatingcurrenciestoECU, was formedunder the conditionsin which somecountries have adoptedregional monetaryarrangements(EU countries, with suchbasescurrencyregimeshybridthat combinesspecific mechanismsto those offixedratefree floating. This paperaims to demonstratethe important role thatithasthe choice ofexchange rateregimeas abasic elementin thefoundationofmacroeconomic stabilizationinstruments. Consideredan expression of thestateof the domestic economyandinternationalcompetitiveness, the exchange rate is determined bya complex set ofexternal factorsorinternalstabilityisa prerequisite forthe crisis.

  20. Proton exchange membrane fuel cells

    CERN Document Server

    Qi, Zhigang


    Preface Proton Exchange Membrane Fuel CellsFuel CellsTypes of Fuel CellsAdvantages of Fuel CellsProton Exchange Membrane Fuel CellsMembraneCatalystCatalyst LayerGas Diffusion MediumMicroporous LayerMembrane Electrode AssemblyPlateSingle CellStackSystemCell Voltage Monitoring Module (CVM)Fuel Supply Module (FSM)Air Supply Module (ASM)Exhaust Management Module (EMM)Heat Management Module (HMM)Water Management Module (WMM)Internal Power Supply Module (IPM)Power Conditioning Module (PCM)Communications Module (COM)Controls Module (CM)SummaryThermodynamics and KineticsTheoretical EfficiencyVoltagePo

  1. [Histone variants and histone exchange]. (United States)

    Wu, Nan; Gui, Jian-Fang


    Histones, as the basic components of nucleosome, are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants' tails. These variants change the conformation and stability of nucleosome to facilitate transcriptional activation or deactivation, DNA repairing, heterochromatin formation, and others. During histone exchange, chromatin remodeling complex facilitates histone variant deposition into nucleosome, and different variants have diverse deposition pathways. Recently, research on histone variants is not only a new hotspot in epigenetics, but also a new annotation of "histone code". In addition, histone exchange reveals new changing mechanism of DNA-histone interaction.

  2. Lipid exchange between Borrelia burgdorferi and host cells.

    Directory of Open Access Journals (Sweden)

    Jameson T Crowley


    Full Text Available Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithelial cells. In addition, through fluorescent and confocal microscopy combined with biochemical approaches, we demonstrated that B. burgdorferi labeled with the fluorescent cholesterol analog BODIPY-cholesterol or (3H-labeled cholesterol transfer both cholesterol and cholesterol-glycolipids to HeLa cells. The transfer occurs through two different mechanisms, by direct contact between the bacteria and eukaryotic cell and/or through release of outer membrane vesicles. Thus, two-way lipid exchange between spirochetes and host cells can occur. This lipid exchange could be an important process that contributes to the pathogenesis of Lyme disease.

  3. Emotional Intelligence predicts individual differences in social exchange reasoning. (United States)

    Reis, Deidre L; Brackett, Marc A; Shamosh, Noah A; Kiehl, Kent A; Salovey, Peter; Gray, Jeremy R


    When assessed with performance measures, Emotional Intelligence (EI) correlates positively with the quality of social relationships. However, the bases of such correlations are not understood in terms of cognitive and neural information processing mechanisms. We investigated whether a performance measure of EI is related to reasoning about social situations (specifically social exchange reasoning) using versions of the Wason Card Selection Task. In an fMRI study (N=16), higher EI predicted hemodynamic responses during social reasoning in the left frontal polar and left anterior temporal brain regions, even when controlling for responses on a very closely matched task (precautionary reasoning). In a larger behavioral study (N=48), higher EI predicted faster social exchange reasoning, after controlling for precautionary reasoning. The results are the first to directly suggest that EI is mediated in part by mechanisms supporting social reasoning and validate a new approach to investigating EI in terms of more basic information processing mechanisms.

  4. Challenges, alternatives, and paths to sustainability for health information exchange efforts. (United States)

    Vest, Joshua R; Campion, Thomas R; Kaushal, Rainu


    Health information exchange (HIE) is a promising approach to improving the cost and quality of healthcare. We sought to identify the strengths and weaknesses of organizational models to achieve exchange, and what can be done to ensure the sustainability and effectiveness of exchange efforts. We interviewed state and national health informatics policy experts (n = 17). Data were collected as part of an evaluation of the Health Care Efficiency and Affordability Law for New Yorkers (HEAL NY) program and included respondents from both the private and public sectors. Data were analyzed using a general inductive and comparative approach with open coding of themes. Interviewees generally viewed HIE as a public or societal good to be valued. However, they identified challenges with the regional health information organization (RHIO) model of facilitating exchange including: economics, organizational issues, and geography. RHIOs were contrasted against alternative methods of exchange such as Direct, enterprise HIE, and vendor-mediated exchange. HIE is a difficult undertaking due to political and economic reasons. Alternatives to the RHIO model have features that may be more attractive to participants, but may be of less public benefit. Using states as intermediaries and mandating exchange under public health law may avoid the challenges facing exchange efforts. Moving forward, policies will have to address the shortcomings of each HIE model to ensure information is effectively shared between providers to maximize health benefits.


    National Research Council Canada - National Science Library

    Jing Jiang; Baiyin Yang


    .... Results revealed a positive relationship between critical thinking and employee creativity, and creative process engagement completely mediated this relationship. Further, leader-member exchange was found to weaken the relationship between critical thinking and creative process engagement. Implications of the study for practice are discussed.

  6. An Exchange Structure Analysis of the Development of Online Intercultural Activity (United States)

    Kitade, Keiko


    Internet-mediated intercultural discussions have been adopted for intercultural and second-language learning. However, the notion of community development in this context has received less attention. This study employs exchange structure (ES) analysis (Stubbs, M. (1983). "Discourse analysis." Oxford: Basil Blackwell) to investigate the…

  7. Exchange asymmetry in experimental settings (United States)

    Thomas C. Brown; Mark D. Morrison; Jacob A. Benfield; Gretchen Nurse Rainbolt; Paul A. Bell


    We review past trading experiments and present 11 new experiments designed to show how the trading rate responds to alterations of the experimental procedure. In agreement with earlier studies, results show that if the trade decision is converted to one resembling a choice between goods the exchange asymmetry disappears, but otherwise the asymmetry is...


    Directory of Open Access Journals (Sweden)



    Full Text Available Using spectral analysis is very common in technical areas but rather unusual in economics and finance, where ARIMA and GARCH modeling are much more in use. To show that spectral analysis can be useful in determining hidden periodic components for high-frequency finance data as well, we use the example of foreign exchange rates

  9. Our International Art Exchange Project. (United States)

    Cocciolone, Kathy R.


    Discusses an international art exchange project designed to teach fifth-grade students that the culture of a country is reflected in its art and that art is a universal language. Describes the contributions from Scotland, Mexico, Saudi Arabia, Egypt, Japan, and India. Points out ways to use materials in schools. (KO)

  10. Milk fouling in heat exchangers

    NARCIS (Netherlands)

    Jeurnink, T.J.M.


    The mechanisms of fouling of heat exchangers by milk were studied. Two major fouling mechanisms were indentified during the heat treatment of milk: (i) the formation and the subsequent deposition of activated serum protein molecules as a result of the heat denaturation; (ii) the

  11. Update of telephone exchange switches

    CERN Multimedia


    Within the scope of the CERN phone services improvement, a software update will be done on exchange switches on Wednesday 27 october from 7.00 pm to 12.00 pm. Disturbances or even interruptions of telephony services may occur during this intervention. We appology in advance for any inconveniences that may occur.

  12. Maintenance of CERN telephone exchanges

    CERN Multimedia


    A maintenance of CERN telephone exchanges will be performed on 21st, 22nd, 23rd, 24th of September from 7 p.m. to 9 p.m. Disturbances or even interruptions of telephony services may occur during this lapse of time. We apology in advance for any inconveniences that this may cause.

  13. The Commodity and its Exchange

    DEFF Research Database (Denmark)

    Høst, Jeppe Engset


    and the value of the quota are examined through the concrete exchange of fishing rights, and it is explained why quota trade can give rise to speculation and monopolies. In the final part of the chapter, it is argued that the value of transferable fishing quotas rely on a social relation between owners...... and nonowners of quota, as a form of monopoly rent....

  14. Baltic Exchange teper v Tallinne

    Index Scriptorium Estoniae


    Viimane osa merekonteineritesse kokkupakitud Londoni laevandus- ja merebörsi Baltic Exchange'i endise peakorteri detailidest jõudis 2007. a. juunis Tallinna. Hoone detailid ostnud ärimehed Heiti Hääl ja Eerik-Niiles Kross plaanivad leida hoonele koha Tallinna kesklinnas. E.-N. Krossi kommentaar

  15. Energy Exchange NASA Opening Plenary (United States)

    Marrs, Rick


    Rick Marrs, Deputy Assistant Administrator Office of Strategic Infrastructure NASA Headquarters will be speaking during the 2017 Energy Exchange opening plenary. His presentation showcases the NASA mission, sustainability at NASA, NASA's strategic Sustainability Performance Plan, Existing PV Partnerships, and NASA funded Solar Initiatives at KSC.

  16. Homans on Exchange: Hedonism Revived (United States)

    Abrahamsson, Bengt


    George C. Homan's theory on social exchange is critically examined and found to have serious shortcomings with regard to its deductive and inductive aspects. An expecially prominent shortcoming concerns the tautological character of his concept of reward," which makes his theory deductively unclear and empirically untestable. Homan's critique…

  17. Common knowledge in email exchanges

    NARCIS (Netherlands)

    Sietsma, F.; Apt, K.R.; van Eijck, D.J.N.; Verbrugge, R.


    We consider a framework in which a group of agents communicates by means of emails, with the possibility of replies, forwards and blind carbon copies (BCC). We study the epistemic consequences of such email exchanges by introducing an appropriate epistemic language and semantics. This allows us to

  18. Knowledge Exchange with Sistema Scotland (United States)

    Allan, Julie; Moran, Nikki; Duffy, Celia; Loening, Gica


    This paper reports on a knowledge exchange project, funded by the Scottish Funding Council and undertaken by a group of researchers from three higher education institutions in Scotland and the project partner, Sistema Scotland. This newly established charity is attempting to implement a major programme of social change, developed in Venezuela,…

  19. Inflationary trispectrum from graviton exchange

    DEFF Research Database (Denmark)

    Seery, David; Sloth, Martin Snoager; Vernizzi, Filippo


    We compute the connected four-point correlation function of the primordial curvature perturbation generated during inflation with standard kinetic terms, where the correlation is established via exchange of a graviton between two pairs of scalar fluctuations. Any such correlation yields a contrib...

  20. Exchange Rate Expectations and the Current Exchange Rate: A Test of the Monetarist Approach


    V S Somanath


    The monetarist model of the exchange rate includes expectations of the future exchange rate as a determinant of the current exchange rate. This paper investigates whether expectations are a significant determinant of the exchange rate. An expectations process that is consistent with a basic monetarist exchange rate model is considered. Alternative measures of expectations are generated using this process. In the empirical tests, while the standard forward exchange premium measure of expectati...

  1. Phase exposure-dependent exchange (United States)

    Ginn, T. R.; Schreyer, L. G.; Zamani, K.


    Solutes and suspended material often experience delays during exchange between phases one of which may be moving. Consequently transport often exhibits combined effects of advection/dispersion, and delays associated with exchange between phases. Such processes are ubiquitous and include transport in porous/fractured media, watersheds, rivers, forest canopies, urban infrastructure systems, and networks. Upscaling approaches often treat the transport and delay mechanisms together, yielding macroscopic "anomalous transport" models. When interaction with the immobile phase is responsible for the delays, it is not the transport that is anomalous, but the lack of it, due to delays. We model such exchanges with a simple generalization of first-order kinetics completely independent of transport. Specifically, we introduce a remobilization rate coefficient that depends on the time in immobile phase. Memory-function formulations of exchange (with or without transport) can be cast in this framework, and can represent practically all time-nonlocal mass balance models including multirate mass transfer and its equivalent counterparts in the continuous time random walk and time-fractional advection dispersion formalisms, as well as equilibrium exchange. Our model can address delayed single-/multievent remobilizations as in delay-differential equations and periodic remobilizations that may be useful in sediment transport modeling. It is also possible to link delay mechanisms with transport if so desired, or to superpose an additional source of nonlocality through the transport operator. This approach allows for mechanistic characterization of the mass transfer process with measurable parameters, and the full set of processes representable by these generalized kinetics is a new open question.

  2. Foreign Exchange Reserves: Bangladesh Perspective

    Directory of Open Access Journals (Sweden)

    Md Zahangir Alam


    Full Text Available This study is about foreign exchangereserves of Bangladesh. The mainpurpose of this study is to the influence of exchange rates on foreign exchangereserves to the Bangladesh context.  Both the primary and secondary data has been used inthis study. The primary data has been collected through a structuredquestionnaire from 50 respondents. The secondary data, namely Bangladeshforeign exchange reserves (FER, Bangladesh current account balance (CAB,Bangladesh capital andfinancial account balance (CFAB, and BDT/USD exchange rates (ER.  This study covers yearly data from July 01,1996 to June 30, 2005 and quarterly data from July 01, 2005 to June 30, 2012. Findingsof this study shows that out of the selected 16 factors affecting foreignexchange reserves, exchange rates occupy the first position, weighted averagescore (WAS being 4.56. Foreign exchange reserves (FER and current accountbalance (CAB have increased by 502.9087% and 1451.218%,whereas capital and financial account (CFAB has decreased by -649.024% on June30, 2012 compared to June 30, 1997. The influence of other factors heldconstant, as ER changes by 285.6894 units due to one unit change in FER, onaverage in the same direction which represents that ER has positive effect on theFER and this relationship is statistically significant.  62.1526 percentof the variation in FER is explained by ER. The outcomes of Breusch-Godfrey test (LM test, ARCHtest, and the Normality test are that there is a serial correlation among residuals, the variance of residuals is notconstant, and the residuals are not normally distributed.

  3. Compact Ceramic Microchannel Heat Exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Lewinsohn, Charles [Ceramatec, Inc., Salt Lake City, UT (United States)


    The objective of the proposed work was to demonstrate the feasibility of a step change in power plant efficiency at a commercially viable cost, by obtaining performance data for prototype, compact, ceramic microchannel heat exchangers. By performing the tasks described in the initial proposal, all of the milestones were met. The work performed will advance the technology from Technology Readiness Level 3 (TRL 3) to Technology Readiness Level 4 (TRL 4) and validate the potential of using these heat exchangers for enabling high efficiency solid oxide fuel cell (SOFC) or high-temperature turbine-based power plants. The attached report will describe how this objective was met. In collaboration with The Colorado School of Mines (CSM), specifications were developed for a high temperature heat exchanger for three commercial microturbines. Microturbines were selected because they are a more mature commercial technology than SOFC, they are a low-volume and high-value target for market entry of high-temperature heat exchangers, and they are essentially scaled-down versions of turbines used in utility-scale power plants. Using these specifications, microchannel dimensions were selected to meet the performance requirements. Ceramic plates were fabricated with microchannels of these dimensions. The plates were tested at room temperature and elevated temperature. Plates were joined together to make modular, heat exchanger stacks that were tested at a variety of temperatures and flow rates. Although gas flow rates equivalent to those in microturbines could not be achieved in the laboratory environment, the results showed expected efficiencies, robust operation under significant temperature gradients at high temperature, and the ability to cycle the stacks. Details of the methods and results are presented in this final report.

  4. Towards a moderated mediation model of innovative work behaviour enhancement

    NARCIS (Netherlands)

    Stoffers, Jol M.; van der Heijden, Beatrice; Notelaers, Guy L.A.


    Purpose – The purpose of this paper is to investigate a moderated mediation model of innovative work behaviour enhancement. Perceived firm (organizational and market) performance was assumed to moderate the relationships between leader-member exchange (LMX) and organizational citizenship behaviour

  5. An RDF-based mediator for health data interoperability. (United States)

    Kuo, Mu-Hsing; Kushniruk, Andre; Borycki, Elizabeth


    In this paper the authors propose and describe a Resource Description Framework (RDF)-based mediator designed to solve the health data interoperability problem that exists among heterogeneous health information systems (e.g., Electronic Health Records). The RDF-based mediator framework has three main components: (1) the Synonym Dictionary (SD) that can be used to map metadata semantics, (2) the CXTR module that can translate source XML-based health documents into RDF-XML format, and (3) the CRTX module that can translate an RDF-XML document into a target XML-based health document. The proposed mediator is expected to make health information exchange more efficient.

  6. Explaining the justice-performance relationship: trust as exchange deepener or trust as uncertainty reducer? (United States)

    Colquitt, Jason A; Lepine, Jeffery A; Piccolo, Ronald F; Zapata, Cindy P; Rich, Bruce L


    Past research has revealed significant relationships between organizational justice dimensions and job performance, and trust is thought to be one mediator of those relationships. However, trust has been positioned in justice theorizing in 2 different ways, either as an indicator of the depth of an exchange relationship or as a variable that reflects levels of work-related uncertainty. Moreover, trust scholars distinguish between multiple forms of trust, including affect- and cognition-based trust, and it remains unclear which form is most relevant to justice effects. To explore these issues, we built and tested a more comprehensive model of trust mediation in which procedural, interpersonal, and distributive justice predicted affect- and cognition-based trust, with those trust forms predicting both exchange- and uncertainty-based mechanisms. The results of a field study in a hospital system revealed that the trust variables did indeed mediate the relationships between the organizational justice dimensions and job performance, with affect-based trust driving exchange-based mediation and cognition-based trust driving uncertainty-based mediation.

  7. Modular Heat Exchanger With Integral Heat Pipe (United States)

    Schreiber, Jeffrey G.


    Modular heat exchanger with integral heat pipe transports heat from source to Stirling engine. Alternative to heat exchangers depending on integrities of thousands of brazed joints, contains only 40 brazed tubes.

  8. Flexible Exchange of Farming Device Data

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Pedersen, Torben Bach


    A new trend in the farming business is to replace conventional farming devices with computerized farming devices. Accordingly, numerous computer-based farming devices for logging, processing and exchanging data have recently been installed on moving farm machinery such as tractors. The exchange...... of data generally takes place between the devices and farming systems, mostly installed at the premises of farmers, contractors, advisory services etc. In most cases, data exchange is based on farming data exchange standards and is bi-directional. Bi-directional data exchange allows different devices...... and systems to exchange data based on a predefined set of rules. In consequence, many hand-coded data exchange solutions have been developed in the farming business. Although efforts regarding incorporating data exchange standards have been made, their actual usage so far has been limited, due to the fact...

  9. The Affect of Leader - Member Exchange on the Employee Performance on The Role of the Employees’ Perception of Organizational Justice

    Directory of Open Access Journals (Sweden)

    Hakan TURGUT


    Full Text Available The purpose of this study can be expressed in two different ways. The first one is two find out the effects of the leader - member exchange on employees organizational justice perception and performances. The second one is to investigate whether or not if organizational justice plays a mediation role on the relationship between leader-member exchange and employee performance. In order to reach our goal, a study has been conducted with the participation of 471 school teachers employed by 20 different schools that provide secondary educational level in Çorum. Results reveal that leader-member exchange has positive and significant effect on organizational justice dimensions (distributive, procedural, interpersonal and informational and employee performance, procedural, interpersonal and informational justice have positive and significant effect on employee performance, also shows that procedural, interpersonal and informational justice have full mediation role on the relationship that occur between leader-member exchange and employee performance.

  10. Rethinking exchange market models as optimization algorithms (United States)

    Luquini, Evandro; Omar, Nizam


    The exchange market model has mainly been used to study the inequality problem. Although the human society inequality problem is very important, the exchange market models dynamics until stationary state and its capability of ranking individuals is interesting in itself. This study considers the hypothesis that the exchange market model could be understood as an optimization procedure. We present herein the implications for algorithmic optimization and also the possibility of a new family of exchange market models

  11. Latin American foreign exchange intervention - Updated


    Da Silva, Sergio; Nunes, Mauricio


    We examine Latin American foreign exchange intervention in a framework where the exchange rate regime is endogenous and there exists an inefficient, equilibrium foreign exchange intervention bias. The model suggests that greater central bank independence is associated with lesser intervention in the foreign exchange market, and also with leaning-against-the-wind intervention. Both results are confirmed by data from 13 Latin American countries.

  12. How to stabilize the currency exchange rate


    BLINOV, Sergey


    In 2015, many countries had to deal with the weakening of their currencies. Issues regarding exchange rate management by the Central Banks have again become the focal point of heated debate. For example, the Russian Ruble exchange rate has been fluctuating hugely. The problem now is not so much the Ruble's weakness as instability of its exchange rate, volatility. The management of the Central Bank claims that stabilization of the Ruble exchange rate is not possible though it is the respons...

  13. Heat exchanger and related methods (United States)

    Turner, Terry D.; McKellar, Michael G.


    Heat exchangers include a housing having an inlet and an outlet and forming a portion of a transition chamber. A heating member may form another portion of the transition chamber. The heating member includes a first end having a first opening and a second end having a second opening larger than the first opening. Methods of conveying a fluid include supplying a first fluid into a transition chamber of a heat exchanger, supplying a second fluid into the transition chamber, and altering a state of a portion of the first fluid with the second fluid. Methods of sublimating solid particles include conveying a first fluid comprising a material in a solid state into a transition chamber, heating the material to a gaseous state by directing a second fluid through a heating member and mixing the first fluid and the second fluid.

  14. The picture exchange communication system. (United States)

    Bondy, A S; Frost, L A


    The Picture Exchange Communication System (PECS) was developed as a means to teach children with autism and related developmental disabilities a rapidly acquired, self-initiating, functional communication system. Its theoretical roots combine principles from applied behavior analysis and guidelines established within the field of alternative and augmentative communication. This approach has several potential advantages relative to imitation-based strategies (both vocal and gestural) and symbol selection strategies. The system begins with the exchange of simple icons but rapidly builds "sentence" structure. The system also emphasizes developing the request function prior to developing responding to simple questions and commenting. The development of requesting with a sentence structure also permits the rapid development of attributes more traditionally taught within a receptive mode. The relationship between the introduction of PECS and various other behavioral issues (i.e., social approach and behavior management) as well as its relationship to the codevelopment of speech are reviewed.

  15. Analysis of Leader Member Exchange

    Directory of Open Access Journals (Sweden)

    Adi Santoso


    Full Text Available This research aims to find out how the relationship of superiors and subordinates works or we call it, LEADER MEMBER EXCHANGE (LMX in another term. The object of this research is an Integrated Nursing Home for Impaired Speech and Hearing (INISPH, ''Meohai” Kendari, with 5 superiors and subordinates of this institution as the research informants. The method used in this research is descriptive qualitative analysis. The research found that the relationship of superiors and subordinates or Leader Member Exchange (LMX, has been well-intertwined, based on the affection, loyalty, enormous contribution, and respect one another toward the profession done in creating a close relationship to achieve the goal.DOI: 10.15408/etk.v15i2.3244

  16. Value Appropriation in Business Exchange

    DEFF Research Database (Denmark)

    Ellegaard, Chris; Medlin, Christopher J.; Geersbro, Jens


    master the difficult balance between value creation and appropriation. This review has provided an overview of the many managerial options for value appropriation and created knowledge on the effects of the various appropriation mechanisms enabling managers to secure company rents while not jeopardizing......Purpose – Value appropriation is a central, yet neglected aspect in business exchange research. The purpose of the paper is to generate an overview of research on active value appropriation in business exchange and provide the foundation for further research into value appropriation, as well...... as some initial guidance for managers. Design/methodology/approach – Literatures investigating value appropriation were identified by the means of a systematic review of the overall management literature. Findings – The authors provide an overview and comparison of the literatures and find that they apply...

  17. High Temperature Composite Heat Exchangers (United States)

    Eckel, Andrew J.; Jaskowiak, Martha H.


    High temperature composite heat exchangers are an enabling technology for a number of aeropropulsion applications. They offer the potential for mass reductions of greater than fifty percent over traditional metallics designs and enable vehicle and engine designs. Since they offer the ability to operate at significantly higher operating temperatures, they facilitate operation at reduced coolant flows and make possible temporary uncooled operation in temperature regimes, such as experienced during vehicle reentry, where traditional heat exchangers require coolant flow. This reduction in coolant requirements can translate into enhanced range or system payload. A brief review of the approaches and challengers to exploiting this important technology are presented, along with a status of recent government-funded projects.

  18. Groundwater–Surface Water Exchange

    DEFF Research Database (Denmark)

    Karan, Sachin

    The exchange of groundwater-surface water has been invetigated in the western part of Denmark. Holtum AA provides the framework for all the performed investigations. Several methods are used, primarily eld based measurements ombined with numerical models to achieve insight to the governing...... processes of interaction between groundwater and surface water. By using heat as a tracer it has been possible to use temperature directly as calibrationtargets in a groundwater and heat transport model. Thus, it is possible to use heat investigate the change in groundwater discharge in dynamic conditions...... by using simple temperature devices along a stream to delineate the areas of interest in regard to GW{SW exchange. Thus, at several locations in a stream a temperature data logger was placed in the water column and right at the streambed-water interface. By looking at the correlation of streambed...

  19. Electrically controlled cesium ion exchange

    Energy Technology Data Exchange (ETDEWEB)

    Lilga, M. [Pacific Northwest Lab., Richland, WA (United States)


    Several sites within the DOE complex (Savannah River, Idaho, Oak Ridge and Hanford) have underground storage tanks containing high-level waste resulting from nuclear engineering activities. To facilitate final disposal of the tank waste, it is advantageous to separate and concentrate the radionuclides for final immobilization in a vitrified glass matrix. This task proposes a new approach for radionuclide separation by combining ion exchange (IX) and electrochemistry to provide a selective and economic separation method.

  20. Value-Added Exchange Rates


    Rudolfs Bems; Robert C. Johnson


    This paper updates the conceptual foundations for measuring real effective exchange rates (REERs) to allow for vertical specialization in trade. We derive a value-added REER describing how demand for the value added that a country produces changes as the price of its value added changes relative to competitors. We then compute this index for 42 countries from 1970-2009 using trade measured in value added terms and GDP deflators. There are substantial differences between value-added and conven...

  1. Exchange, phenomenology and the Self


    Galonska, Deniece; Yener, Efe Can; Sørensen, Karen Mallya; Olesen, Tine Lautrup


    The research project aims to investigate the ‘Self’ concerning the experience of being an international exchange student. As the research approaches the three participants as unique individuals, phenomenology provided a foundation regarding the ontological stance and a method. The philosophy of phenomenology and its different interview methods will be discussed, in relation to perspectives by Edmund Husserl and Martin Heidegger, with attention aimed at the question whether or not objectiv...

  2. Review of Fractal Heat Exchangers


    Huang, Zhiwei; Hwang, Yunho; Aute, Vikrant; Radermacher, Reinhard


    Nature has inspired many scientists and engineers to solve problems through observation and mimicry. One such example is heat transfer enhancement. The enormous natural heat and mass transfer phenomena have led engineers to seek solutions to heat transfer enhancement problems from nature. Fractal geometries are found in respiratory and vascular systems of plants and animals, such as blood vessels, human lungs, leaves, coastlines, etc. Inspired by this, fractal heat exchangers have been develo...

  3. Prison needle exchange programs work. (United States)


    On 27 October 2004 the Canadian HIV/AIDS Legal Network and the Ontario Medical Association (OMA) released reports recommending that needle exchange programs (NEPs) be implemented in prisons, based on evidence that such programs promote and protect the health of both prisoners and prison staff. At the same time, the Scottish Prison Service announced that it was looking at providing such programs, and an Iranian physician reported on a pilot project in his country.

  4. Ion-exchange chromatographic protein refolding

    NARCIS (Netherlands)

    Freydell, E.; Wielen, van der L.; Eppink, M.H.M.; Ottens, M.


    The application of ion-exchange (IEX) chromatography to protein refolding (IExR) has been successfully proven, as supported by various studies using different model proteins, ion-exchange media and flow configurations. Ion-exchange refolding offers a relatively high degree of process

  5. Monetary and Exchange Rate Policy in Slovenia


    Gonzalo Caprirolo; Vladimir Lavrac


    The paper is divided in three sections presenting some stylized facts concerning monetary and exchange rate policy framework in Slovenia. Three periods are covered: Money-based Stabilization Policy (1991-1995), Price and Real Exchange Rate Stability Dual Targeting Policy (1996-2001), and Exchange Rate Based Stabilization Policy and Accession to ERM2 (2001-).

  6. 78 FR 38203 - Refunds and Exchanges (United States)


    ... Service through the manager, Payment Technology, USPS Headquarters. Subsequently, as part of this final... from the manager, Payment Technology (see 608.8.1 for address). * * * * * 9.0 Exchanges and Refunds... Not Exchangeable The following postage items cannot be exchanged: a. Adhesive stamps, unless mistakes...

  7. Cryogenic Heat Exchanger with Turbulent Flows (United States)

    Amrit, Jay; Douay, Christelle; Dubois, Francis; Defresne, Gerard


    An evaporator-type cryogenic heat exchanger is designed and built for introducing fluid-solid heat exchange phenomena to undergraduates in a practical and efficient way. The heat exchanger functions at liquid nitrogen temperature and enables cooling of N[subscript 2] and He gases from room temperatures. We present first the experimental results of…

  8. The magic of knowledge exchange

    CERN Multimedia

    CERN Bulletin


    “If you have an apple and I have an apple and we exchange these apples then you and I will still each have one apple. But if you have an idea and I have an idea and we exchange these ideas, then each of us will have two ideas”. (George Bernard Shaw). The CERN Global Network is a new, ideal place for past and present members of the CERN community to share ideas and create new links.   On 29 April, CERN’s Knowledge and Technology Transfer (KTT) Group launched the CERN Global Network, a tool whose aim is to facilitate knowledge exchanges inside and outside CERN. "Among the greatest ambassadors of knowledge are people who have been trained and educated at CERN and also at other institutes: here is where the Global Network comes into play", says Rolf Heuer, CERN Director General. “During the first phase, the Network will be open to current and former members of the CERN personnel, that is, staff, fellows, apprentices, associates, students a...


    Energy Technology Data Exchange (ETDEWEB)

    Bunge, A.L.; Klein, G.; Radke, C.J.


    Exchange of hardness ions is important in enhanced oil recovery with chemical additives. In both micellar-polymer and caustic flooding processes, multivalent ions released from rock surfaces can interact with anionic surfactants, rendering them preferentially oil soluble and/or insoluble in water. Because hardness cations are sparingly soluble and precipitate in alkaline solutions, such solutions may be more efficient as surfactant flood preflushes than are softened brines. Multivalent ion precipitation may also occur in alkaline waterflooding. To permit design of such processes, this paper presents a chromatographic theory for simultaneous ion exchange with precipitation of divalent ions. Theoretical effluent histories and concentration profiles are presented for the cases of finite pulses and continuous injection of hydroxide ions into linear cores. Complete capture of the insoluble salt particles is assumed. Results are given for the case of instantaneous equilibration of the solution with the precipitate, as well for the case of complete nonequilibrium, in which the solid precipitate does not redissolve. The efficiency of alklaine preflushing is shown to depend on the exchange isotherm, initial divalent loading of the rock, injected pH and salinity, the solubility product of the precipitated salt, and pulse size. The effect of slug size on complete equilibrium removal of hardness ions is reduced efficiency with increasing size until a critical volume approximating continuous injection is reached. Increasing injected pH and salinity provides a more favorable response. Experimental data for Berea sandstone and an argillaceous sand compare favorably with the proposed theory.


    Energy Technology Data Exchange (ETDEWEB)

    Boltz, J.C. (ed.)


    This report discusses the following topics on computer environments: Releasing computer software outside EG G Idaho; Ilford digital photo imager; mandatory upgrade of PC ORPS software; ORPS host computer upgrade; EROB computer users see network change; password expiration notice; big iron still has place in HPC market; handy scripts to copy and move files; more on workstation password expiration; training center course schedule for April 1993; Microsoft Word Version 5.1a- button bar; file attributes can provide you greater flexibility; constructing a personal WordPerfect dictionary; and Windows shortcuts.

  11. Direct Exchange Mechanism for Interlayer Ions in Non-Swelling Clays. (United States)

    Ruiz Pestana, Luis; Kolluri, Kedarnath; Head-Gordon, Teresa; Lammers, Laura Nielsen


    The mobility of radiocesium in the environment is largely mediated by cation exchange in micaceous clays, in particular Illite-a non-swelling clay mineral that naturally contains interlayer K + and has high affinity for Cs + . Although exchange of interlayer K + for Cs + is nearly thermodynamically nonselective, recent experiments show that direct, anhydrous Cs + -K + exchange is kinetically viable and leads to the formation of phase-separated interlayers through a mechanism that remains unclear. Here, using classical atomistic simulations and density functional theory calculations, we identify a molecular-scale positive feedback mechanism in which exchange of the larger Cs + for the smaller K + significantly lowers the migration barrier of neighboring K + , allowing exchange to propagate rapidly once initiated at the clay edge. Barrier lowering upon slight increase in layer spacing (∼0.7 Å) during Cs + exchange is an example of "chemical-mechanical coupling" that likely explains the observed sharp exchange fronts leading to interstratification. Interestingly, we find that these features are thermodynamically favored even in the absence of a heterogeneous layer charge distribution.

  12. mediation: R Package for Causal Mediation Analysis

    Directory of Open Access Journals (Sweden)

    Dustin Tingley


    Full Text Available In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding the process in which the treatment causally affects the outcome. Causal mediation analysis is frequently used to assess potential causal mechanisms. The mediation package implements a comprehensive suite of statistical tools for conducting such an analysis. The package is organized into two distinct approaches. Using the model-based approach, researchers can estimate causal mediation effects and conduct sensitivity analysis under the standard research design. Furthermore, the design-based approach provides several analysis tools that are applicable under different experimental designs. This approach requires weaker assumptions than the model-based approach. We also implement a statistical method for dealing with multiple (causally dependent mediators, which are often encountered in practice. Finally, the package also offers a methodology for assessing causal mediation in the presence of treatment noncompliance, a common problem in randomized trials.


    Directory of Open Access Journals (Sweden)

    Alexander Ponomarev


    Full Text Available This article focuses on the legal model of mediation agreements in Russian and international legislation. The authors consider the main provisions of the mediation agreements in civil matters, in particular, is defined by such features of the legal model as the requirements for this type of agreements. In addition, the article discusses the problematic issues of implementation of mediation agreements.

  14. The determinants of exchange rate in Croatia

    Directory of Open Access Journals (Sweden)

    Manuel BENAZIC


    Full Text Available The dilemma for every country with an independent monetary policy is which kind of exchange rate arrangement should be applied. Through the exchange rate policy, countries can influence their economies, i.e. price stability and export competiveness. Croatia is a new EU member state, it has its own monetary policy and currency but it is on the way to euro introduction. Regarding the experiences from the beginning of the 1990s when Croatia was faced with serious monetary instabilities and hyperinflation, the goal of Croatian National Bank (CNB is to ensure price stability and one way to do so is through exchange rate policy. Croatia, as a small and open economy, has applied a managed floating exchange rate regime. The exchange rate is determined primarily by the foreign exchange supply and demand on the foreign exchange market, with occasional market interventions by the CNB. Therefore, in order to maintain exchange rate stability, policymakers must be able to recognize how changes in these factors affect changes in the exchange rate. This research aims to find a relationship among the main sources of foreign currency inflow and outflow and the level of exchange rate in Croatia. The analysis is carried out by using the bounds testing (ARDL approach for co-integration. The results indicate the existence of a stable co-integration relationship between the observed variables, whereby an increase in the majority of variables leads to an exchange rate appreciation.

  15. A Review of Industrial Heat Exchange Optimization (United States)

    Yao, Junjie


    Heat exchanger is an energy exchange equipment, it transfers the heat from a working medium to another working medium, which has been wildly used in petrochemical industry, HVAC refrigeration, aerospace and so many other fields. The optimal design and efficient operation of the heat exchanger and heat transfer network are of great significance to the process industry to realize energy conservation, production cost reduction and energy consumption reduction. In this paper, the optimization of heat exchanger, optimal algorithm and heat exchanger optimization with different objective functions are discussed. Then, optimization of the heat exchanger and the heat exchanger network considering different conditions are compared and analysed. Finally, all the problems discussed are summarized and foresights are proposed.

  16. Heat exchanger with oscillating flow (United States)

    Scotti, Stephen J. (Inventor); Blosser, Max L. (Inventor); Camarda, Charles J. (Inventor)


    Various heat exchange apparatuses are described in which an oscillating flow of primary coolant is used to dissipate an incident heat flux. The oscillating flow may be imparted by a reciprocating piston, a double action twin reciprocating piston, fluidic oscillators or electromagnetic pumps. The oscillating fluid flows through at least one conduit in either an open loop or a closed loop. A secondary flow of coolant may be used to flow over the outer walls of at least one conduit to remove heat transferred from the primary coolant to the walls of the conduit.

  17. Information exchanges in cournot duopolies

    Directory of Open Access Journals (Sweden)

    Faíña Medín J. Andrés


    Full Text Available In this paper we analyze the profitability of information sharing among Cournot oligopolists receiving private information about random demand. We model the random demand as a linear demand having, 1 an unknown intercept, and 2 an unknown slope. In each of these two scenarios, firms observe private signals about the unknown parameter. We show that in the scenario-1, if the private signal observed by firms is accurate enough, information exchange is profitable and in the scenario-2, if there is a sufficiently large variation in the demand slope and private signals are accurate enough, firms earn strictly higher profits by sharing their information rather than keeping it private.



    V. L. Dobin; V. G. Demikhov; M. P. Zharikova


    The review analyzes the major foreign publications on the iron exchange in mycobacteria for the recent years. The issues of iron absorption by tuberculous mycobacteria, its preservation and regulation of their metabolism have been reviewed. Deeper and more detail description of the above process will provide new opportunities for therapeutic interventions into it and assist in development of new tuberculosis treatment techniques.


    Directory of Open Access Journals (Sweden)

    V. L. Dobin


    Full Text Available The review analyzes the major foreign publications on the iron exchange in mycobacteria for the recent years. The issues of iron absorption by tuberculous mycobacteria, its preservation and regulation of their metabolism have been reviewed. Deeper and more detail description of the above process will provide new opportunities for therapeutic interventions into it and assist in development of new tuberculosis treatment techniques.

  20. EPR of exchange coupled systems

    CERN Document Server

    Bencini, Alessandro


    From chemistry to solid state physics to biology, the applications of Electron Paramagnetic Resonance (EPR) are relevant to many areas. This unified treatment is based on the spin Hamiltonian approach and makes extensive use of irreducible tensor techniques to analyze systems in which two or more spins are magnetically coupled. This edition contains a new Introduction by coauthor Dante Gatteschi, a pioneer and scholar of molecular magnetism.The first two chapters review the foundations of exchange interactions, followed by examinations of the spectra of pairs and clusters, relaxation in oligon

  1. Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domain. (United States)

    Zhang, Xue-Qian; Wang, Jufang; Carl, Lois L; Song, Jianliang; Ahlers, Belinda A; Cheung, Joseph Y


    Phospholemman (PLM) belongs to the FXYD family of small ion transport regulators. When phosphorylated at Ser(68), PLM inhibits cardiac Na(+)/Ca(2+) exchanger (NCX1). We previously demonstrated that the cytoplasmic tail of PLM interacts with the proximal intracellular loop (residues 218-358), but not the transmembrane (residues 1-217 and 765-938) or Ca(2+)-binding (residues 371-508) domains, of NCX1. In this study, we used intact Na(+)/Ca(2+) exchanger with various deletions in the intracellular loop to map the interaction sites with PLM. We first demonstrated by Western blotting and confocal immunofluorescence microscopy that wild-type (WT) NCX1 and its deletion mutants were expressed in transfected HEK-293 cells. Cotransfection with PLM and NCX1 (or its deletion mutants) in HEK-293 cells did not decrease expression of NCX1 (or its deletion mutants). Coexpression of PLM with WT NCX1 inhibited NCX1 current (I(NaCa)). Deletion of residues 240-679, 265-373, 250-300, or 300-373 from WT NCX1 resulted in loss of inhibition of I(NaCa) by PLM. Inhibition of I(NaCa) by PLM was preserved when residues 229-237, 270-300, 328-330, or 330-373 were deleted from the intracellular loop of NCX1. These results suggest that PLM mediated inhibition of I(NaCa) by interacting with two distinct regions (residues 238-270 and 300-328) of NCX1. Indeed, I(NaCa) measured in mutants lacking residues 238-270, 300-328, or 238-270 + 300-328 was not affected by PLM. Glutathione S-transferase pull-down assays confirmed that PLM bound to fragments corresponding to residues 218-371, 218-320, 218-270, 238-371, and 300-373, but not to fragments encompassing residues 250-300 and 371-508 of NCX1, indicating that residues 218-270 and 300-373 physically associated with PLM. Finally, acute regulation of I(NaCa) by PLM phosphorylation observed with WT NCX1 was absent in 250-300 deletion mutant but preserved in 229-237 deletion mutant. We conclude that PLM mediates its inhibition of NCX1 by interacting with

  2. Ferromagnetism and interlayer exchange coupling in thin metallic films

    Energy Technology Data Exchange (ETDEWEB)

    Kienert, Jochen


    This thesis is concerned with the ferromagnetic Kondo lattice (s-d,s-f) model for film geometry. The spin-fermion interaction of this model refers to substances in which localized spins interact with mobile charge carriers like in (dilute) magnetic semiconductors, manganites, or rare-earth compounds. The carrier-mediated, indirect interaction between the localized spins comprises the long-range, oscillatory RKKY exchange interaction in the weak-coupling case and the short-range doubleexchange interaction for strong spin-fermion coupling. Both limits are recovered in this work by mapping the problem onto an effective Heisenberg model. The influence of reduced translational symmetry on the effective exchange interaction and on the magnetic properties of the ferromagnetic Kondo lattice model is investigated. Curie temperatures are obtained for different parameter constellations. The consequences of charge transfer and of lattice relaxation on the magnetic stability at the surface are considered. Since the effective exchange integrals are closely related to the electronic structure in terms of the density of states and of the kinetic energy, the discussion is based on the modifications of these quantities in the dimensionally-reduced case. The important role of spin waves for thin film and surface magnetism is demonstrated. Interlayer exchange coupling represents a particularly interesting and important manifestation of the indirect interaction among localized magnetic moments. The coupling between monatomic layers in thin films is studied in the framework of an RKKY approach. It is decisively determined by the type of in-plane and perpendicular dispersion of the charge carriers and is strongly suppressed above a critical value of the Fermi energy. Finally, the temperature-dependent magnetic stability of thin interlayer-coupled films is addressed and the conditions for a temperature-driven magnetic reorientation transition are discussed. (orig.)

  3. 31 CFR 515.325 - National securities exchange. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false National securities exchange. 515.325... Definitions § 515.325 National securities exchange. The term national securities exchange shall mean an exchange registered as a national securities exchange under section 6 of the Securities Exchange Act of...

  4. 31 CFR 500.325 - National securities exchange. (United States)


    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false National securities exchange. 500.325... Definitions § 500.325 National securities exchange. The term national securities exchange shall mean an exchange registered as a national securities exchange under section 6 of the Securities Exchange Act of...

  5. Inorganic ion exchangers for nuclear waste remediation

    Energy Technology Data Exchange (ETDEWEB)

    Clearfield, A.; Bortun, A.; Bortun, L.; Behrens, E. [Texas A& M Univ., College Station, TX (United States)


    The objective of this work is to provide a broad spectrum of inorganic ion exchangers that can be used for a range of applications and separations involving remediation of groundwater and tank wastes. The authors intend to scale-up the most promising exchangers, through partnership with AlliedSignal Inc., to provide samples for testing at various DOE sites. While much of the focus is on exchangers for removal of Cs{sup +} and Sr{sup 2+} from highly alkaline tank wastes, especially at Hanford, the authors have also synthesized exchangers for acid wastes, alkaline wastes, groundwater, and mercury, cobalt, and chromium removal. These exchangers are now available for use at DOE sites. Many of the ion exchangers described here are new, and others are improved versions of previously known exchangers. They are generally one of three types: (1) layered compounds, (2) framework or tunnel compounds, and (3) amorphous exchangers in which a gel exchanger is used to bind a fine powder into a bead for column use. Most of these exchangers can be regenerated and used again.

  6. How did China's foreign exchange reform affect the efficiency of foreign exchange market? (United States)

    Ning, Ye; Wang, Yiming; Su, Chi-wei


    This study compares the market efficiency of China's onshore and offshore foreign exchange markets before and after the foreign exchange reform on August 11, 2015. We use the multifractal detrended fluctuation analysis of the onshore and offshore RMB/USD spot exchange rate series as basis. We then find that the onshore foreign exchange market before the reform has the lowest market efficiency, which increased after the reform. The offshore foreign exchange market before the reform has the highest market efficiency, which dropped after the reform. This finding implies the increased efficiency of the onshore foreign exchange market and the loss of efficiency in the offshore foreign exchange market. We also find that the offshore foreign exchange market is more efficient than the onshore market and that the gap shrank after the reform. Changes in intervention of the People's Bank of China since the reform is a possible explanation for the changes in the efficiency of the foreign exchange market.

  7. Phase-exchange thermoacoustic engine (United States)

    Offner, Avshalom; Meir, Avishai; Ramon, Guy Z.; WET Lab Team


    Phase-exchange thermoacoustic engines are reliable machines holding great promise in converting heat from low grade heat sources to mechanical or electrical power. In these engines the working fluid is a gas mixture containing one condensable component, decreasing the temperature difference required for ignition and steady state operation. Our experimental setup consists of a vertical acoustic resonator containing a mixture of air-water vapor. Water evaporates near the heat source, condenses at the heat sink and is drawn back down by gravity and capillary forces where it re-evaporates, sustaining a steady state closed thermodynamic cycle. We investigated the stability limit, namely the critical point at which temperature difference in the engine enables onset of self-excited oscillations, and the steady state of the engine. A simple theoretical model was derived, describing mechanisms of irreversible entropy generation and production of acoustic power in such engines. This model captures the essence in the differences between regular and phase-exchange thermoacoustic engines, and shows good agreement with experimental results of stability limit. Steady state results reveal not only a dramatic decrease in temperature difference, but also an increase in engine performances. The authors acknowledge the support from the Nancy and Stephen Grand Technion Energy Program (GTEP).

  8. Dipole-induced exchange bias. (United States)

    Torres, Felipe; Morales, Rafael; Schuller, Ivan K; Kiwi, Miguel


    The discovery of dipole-induced exchange bias (EB), switching from negative to positive sign, is reported in systems where the antiferromagnet and the ferromagnet are separated by a paramagnetic spacer (AFM-PM-FM). The magnitude and sign of the EB is determined by the cooling field strength and the PM thickness. The same cooling field yields negative EB for thin spacers, and positive EB for thicker ones. The EB decay profile as a function of the spacer thickness, and the change of sign, are attributed to long-ranged dipole coupling. Our model, which accounts quantitatively for the experimental results, ignores the short range interfacial exchange interactions of the usual EB theories. Instead, it retains solely the long range dipole field that allows for the coupling of the FM and AFM across the PM spacer. The experiments allow for novel switching capabilities of long range EB systems, while the theory allows description of the structures where the FM and AFM are not in atomic contact. The results provide a new approach to design novel interacting heterostructures.

  9. Exchange of astronomy teaching experiences (United States)

    Ros, Rosa M.

    The Working Group of the European Association for Astronomy Education responsible for Teacher Training organises an annual Summer School for teachers under expert guidance. For a week the teachers participating can exchange experiences, increase their knowledge and discuss different ideas and perspectives. In general, the instructors are professional astronomers, professors and teachers from different countries. The papers presented offer very practical activities, paying special attention to didactic aspects, and take the form of general lectures to all 40 participants and workshops to reduced groups of 20 participants. There are also day and night observations, without expensive equipment or complicated procedures, that are easy to set up and based on topics that it is possible to use in the classroom. The Summer Schools promote a scientific astronomical education at all levels of astronomy teaching, reinforce the link between professional astronomers and teachers with experience of teaching astronomy, allow debates among the participants on their pedagogical activities already carried out in their own classroom and help them to organise activities outside it. Astronomy teachers need special training, access to specific research, to new educational materials and methods and the opportunity to exchange experiences. All these things are provided by the Summer School.

  10. DHE (downhole heat exchangers). [Downhole Heat Exchangers (DHE)

    Energy Technology Data Exchange (ETDEWEB)

    Culver, G.


    The use of downhole heat exchangers (DHE) for residential or commercial space and domestic water heating and other applications has several desirable features. Systems are nearly or completely passive -- that is, no or very little geothermal water or steam is produced from the well either reducing or completely eliminating surface environmental concerns and the need for disposal systems or injection wells. Initial cost of pumps and installation are eliminated or reduced along with pumping power costs and maintenance costs associated with pumping often corrosive geothermal fluids. Many residential and small commercial systems do not require circulating pumps because the density difference in the incoming and outgoing sides of the loop are sufficient to overcome circulating friction losses in the entire system. The major disadvantage of DHEs is their dependence on natural heat flow. In areas where geological conditions provide high permeability and a natural hydraulic gradient, DHEs can provide a substantial quantity of heat. A single 500-ft (152 m) well in Klamath Falls, Oregon, supplies over one megawatt thermal and output is apparently limited by the surface area of pipe that can be installed in the well bore. In contrast, DHEs used in conjunction with heat pumps may supply less than 8 KW from a well of similar depth. Here output is limited by conductive heat flow with perhaps a small contribution from convection near the well bore. The highest capacity DHE reported to date, in Turkey, supplies 6 MW thermal from an 820-ft (250 m) well. There were two main goals for this project. The first was to gather, disseminate and exchange internationally information on DHES. The second was to perform experiments that would provide insight into well bore/aquifer interaction and thereby provide more information on which to base DHE designs. 27 refs., 31 figs., 3 tabs.

  11. Investigating the effects of liquidity and exchange rate on Tehran Stock Exchange

    Directory of Open Access Journals (Sweden)

    Younos Vakil Alroaia


    Full Text Available This paper presents an empirical investigation to study the effects of two macroeconomic factors; namely exchange rate and liquidity on stock index. The proposed study was applied in Iran and on major index of Tehran Stock Exchange over the period 2001-2011. They reported that the currency exchange maintained negative impact on stock exchange for the period of investigation. This is due to the fact that when currency devalued, working capital decreases and firms did not enough money to purchase raw materials, pay wages, etc. In addition, liquidity marinated a direct and positive relationship with exchange index. However, the impact of liquidity seems to be bigger than currency exchange.

  12. Needs Assessment for Exchange Students in Taiwan

    Directory of Open Access Journals (Sweden)

    Kentei Takaya


    Full Text Available With the growing mobility of international students in Asia and the Pacific, Taiwan has become actively involved in promoting international academic exchange. This research investigates the experience of exchange students from the Philippines and mainland China and examines their needs while studying in Taiwan. Qualitative in-depth interviews were conducted with exchange students from the Philippines and mainland China. The findings suggest that while exchange students from the Philippines and mainland China both encountered difficulties during their study in Taiwan, exchange students from the Philippines were inclined to encounter more difficulties compared to those from mainland China due to language difficulties. Based on the findings of this study, suggested support services for future exchange students in Taiwan are outlined to match the needs of students from both Chinese and non-Chinese-speaking backgrounds.

  13. Listening to agent agendas in student exchanges

    DEFF Research Database (Denmark)

    Tarp, Gertrud


    The paper is based upon a research study of short-term student exchanges. The study took place from 1996-2000, and comprises seven classes of students from six Danish business schools. Short-term student exchanges in terms of EU funded exchanges and local school exchanges are means to develop...... the students’ understanding of their own cultural background and of foreign cultures. The research study is an attempt to look at internationalisation and student exchanges from a student perspective. Thus the structural aim and the structural framework are considered given elements. The study is based upon...... institutional scepticism and placed within the theoretical framework of symbolic interactionism. The methodology applied is qualitative, grounded theory, and the data originate from diaries, semi-structured interviews and semi-open questionnaires. The findings show that the students have their own exchange...

  14. Thermal diversities of two Na+/H+ exchanges in guinea pig red cells. (United States)

    Ji, H L


    To test the effect of hypothermia on Na+/H+ exchange, activated by shrinkage and cytoplasmic acidosis. Amiloride-sensitive Na+ influx in guinea pig red cells was traced with isotope 22Na and intracellular Na+ concentration was measured by emission flame photometry. Amiloride-sensitive Na+ influx decreased linearly as a function of temperatures (about 37 degrees C) in shrunken cells, but increased in acidified cells. The up-regulation of acid-induced Na+/H+ exchange by elevated temperature was enhanced by hypo-osmolarity. Less sensitivity of intracellular H+ site at 41 degrees C may be the mechanism for the inhibition of shrinkage-induced Na+/H+ exchange by elevated temperature. Heating-mediated explosive increase in the activity of acid-induced Na+/H+ exchange may be due to enhanced extracellular Na+ sensitivity and lower intracellular pH caused by acidic metabolites. Acid-induced Na+/H+ exchange contributes to cytoplasmic Na+ accumulation. These two modes of Na+/H+ exchange with different response to elevated temperature may play different roles in the cellular pathogenesis of heatstroke.

  15. The use of therapeutic plasma exchange to reduce serum bilirubin in a dog with kernicterus. (United States)

    Tovar, Tricia; Deitschel, Sarah; Guenther, Christine


    To describe the use of a manual method of therapeutic plasma exchange to reduce total serum bilirubin, manage kernicterus, and halt progression of neurological dysfunction in a dog with immune-mediated hemolytic anemia (IMHA). A 5-year-old male neutered Lhasa Apso diagnosed with IMHA developed acute onset neurologic signs consistent with kernicterus. Manual therapeutic plasma exchange was performed in an attempt to reduce total serum bilirubin. The initial exchange was performed at a lower plasma exchange volume due to the dog's critical status and the dog's clinical signs progressed. More aggressive plasma exchange was performed that resulted in a reduction in total serum bilirubin and no further progression of neurologic signs. The dog was euthanized due to suspicion of permanent neurologic changes and need for further blood transfusions. Histopathology postmortem confirmed a diagnosis of kernicterus. Kernicterus secondary to hyperbilirubinemia is well described in people, but has rarely been reported in dogs. Therapeutic plasma exchange has been used for decades in people to rapidly decrease serum bilirubin when hyperbilirubinemia progresses to neurologic signs, but to the authors' knowledge this has not been described in a dog. © Veterinary Emergency and Critical Care Society 2017.

  16. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.


    This study analyzes how a group of ‘mediators’ in a large, multinational company adapted a computer-mediated communication technology (a ‘virtual workspace’) to the organizational context (and vice versa) by modifying features of the technology, providing ongoing support for users, and promoting...... of technology-use mediation is more complex and indeterminate than earlier literature suggests. In particular, we want to draw attention to the fact that advanced computer-mediated communication technologies are equivocal and that technology-use mediation consequently requires ongoing sensemaking (Weick 1995)....... appropriate conventions of use. Our findings corroborate earlier research on technology-use mediation, which suggests that such mediators can exert considerable influence on how a particular technology will be established and used in an organization. However, this study also indicates that the process...

  17. Incentives and Information Exchange in International Taxation


    Keen, M.; Ligthart, J.E.


    The exchange of taxpayer-specific information between national tax authorities has recently emerged as a key and controversial topic in international tax policy discussions, most notably with the OECD s harmful tax practices project and the EU s savings tax initiative.This paper analyses the effects of information exchange and withholding taxes, recognizing that countries which agree to exchange information do not forfeit the ability to levy withholding taxes, and also focusing in particular ...

  18. Development of nursing students during international exchange


    Varusk, Inge


    The purpose of the study was to gather information about the experiences which nursing exchange students have had when they have been abroad. This aim of this literature review was to evaluates and presents the most current and relevant information of the topic as possible. The findings were divided into two themes – how nursing exchange students had evolved on a personal and on a professional level. Most of the findings were about how the nursing exchange students had evolved on a person...

  19. [Plasma exchange in nephrology: Indications and technique]. (United States)

    Ridel, Christophe; Kissling, Sébastien; Mesnard, Laurent; Hertig, Alexandre; Rondeau, Éric


    Plasma exchange is a non-selective apheresis technique that can be performed by filtration or centrifugation allowing rapid purification of high molecular weight pathogens. An immunosuppressive treatment is generally associated to reduce the rebound effect of the purified substance. Substitution solutes such as human albumin and macromolecules are needed to compensate for plasma extraction. Compensation by viro-attenuated plasma is reserved solely for the treatment of thrombotic microangiopathies or when there is a risk of bleeding, because this product is very allergenic and expensive. The treatment goal for a plasma exchange session should be between one and one and one-half times the patient's plasma volume estimated at 40 mL/kg body weight. The anticoagulation is best ensured by the citrate. Complications of plasma exchange are quite rare according to the French hemapheresis registry. The level of evidence of efficacy of plasma exchange in nephrology varies from one pathology to another. Main indications of plasma exchange in nephrology are Goodpasture syndrome, antineutrophil cytoplasmic antibody vasculitis when plasma creatinine is greater than 500 μmol/L, and thrombotic microangiopathies. During renal transplantation, plasma exchange may be proposed in the context of human leukocyte antigen (HLA) desensitization protocols or ABO-incompatible graft. After renal transplantation, plasma exchange is indicated as part of the treatment of acute humoral rejection or recurrent focal segmental glomerulosclerosis on the graft. Plasma exchanges are also proposed in the management of cryoglobulinemia or polyarteritis nodosa. Hemodialysis with membranes of very high permeability tends to replace plasma exchange for myeloma nephropathy. The benefit from plasma exchange has not been formally demonstrated for the treatment of severe lupus or antiphospholipid antibody syndrome. There is no indication of plasma exchange in the treatment of scleroderma or nephrogenic

  20. Electric control of exchange bias training. (United States)

    Echtenkamp, W; Binek, Ch


    Voltage-controlled exchange bias training and tunability are introduced. Isothermal voltage pulses are used to reverse the antiferromagnetic order parameter of magnetoelectric Cr(2)O(3), and thus continuously tune the exchange bias of an adjacent CoPd film. Voltage-controlled exchange bias training is initialized by tuning the antiferromagnetic interface into a nonequilibrium state incommensurate with the underlying bulk. Interpretation of these hitherto unreported effects contributes to new understanding in electrically controlled magnetism.

  1. China: Exchange Rate Policy and Asian Trade


    Alicia García-Herrero; Tuuli Koivu


    This paper shows empirically that China s trade balance is sensitive to fluctuations in the renminbi real effective exchange rate. However, the current size of the trade surplus is such that exchange rate policy, alone, will probably not be able to address the imbalance. The reduction in the trade surplus is limited mainly because Chinese imports do not react as expected to exchange rate appreciation. In fact, they tend to fall rather than increase. By estimating bilateral import equations fo...

  2. Fluid to fluid contact heat exchanger (United States)

    Clark, W. E.


    Heat transfer and pressure drop test results for a fluid to fluid contact heat exchanger are reported. The heat exchanger, fabricated and tested to demonstrate one method of transferring heat between structures in space, had a total contact area of 0.18 sq m. It utilized contact surfaces which were flexible and conformed to the mating contact surfaces upon pressurization of the fluid circulating within the heat exchanger. During proof-of-concept performance tests, the heat exchanger was operated in a typical earth environment. It demonstrated a contact conductance of 3.8 kW/sq m C at contact pressures in the 15 to 70 kPa range.

  3. Essential Specification Elements for Heat Exchanger Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Bower, L.


    Performance upgrade and equipment degradation are the primary impetuses for a nuclear power plant to engage in the large capital cost project of heat exchanger replacement. Along with attention to these issues, consideration of heat exchanger Codes and Standards, material improvements, thermal redesign, and configuration are essential for developing User’s Design Specifications for successful replacement projects. The User’s Design Specification is the central document in procuring ASME heat exchangers. Properly stated objectives for the heat exchanger replacement are essential for obtaining the materials, configurations and thermal designs best suited for the nuclear power plant. Additionally, the code of construction required and the applied manufacturing standard (TEMA or HEI) affects how the heat exchanger may be designed or configured to meet the replacement goals. Knowledge of how Codes and Standards affect design and configuration details will aid in writing the User’s Design Specification. Joseph Oat Corporation has designed and fabricated many replacement heat exchangers for the nuclear power industry. These heat exchangers have been constructed per ASME Section III to various Code-Years or ASME Section VIII-1 to the current Code-Year also in accordance with TEMA and HEI. These heat exchangers have been a range of like-for-like replacement to complete thermal, material and configuration redesigns. Several examples of these heat exchangers with their Code, Standard and specification implications are presented. (Author.

  4. Ion Exchange and Liquid Column Chromatography. (United States)

    Walton, Harold F.


    Emphasizes recent advances in principles and methodology in ion exchange and chromatography. Two tables list representative examples for inorganic ions and organic compounds. Cites 544 references. (CS)

  5. Entropy exchange for infinite-dimensional systems. (United States)

    Duan, Zhoubo; Hou, Jinchuan


    In this paper the entropy exchange for channels and states in infinite-dimensional systems are defined and studied. It is shown that, this entropy exchange depends only on the given channel and the state. An explicit expression of the entropy exchange in terms of the state and the channel is proposed. The generalized Klein's inequality, the subadditivity and the triangle inequality about the entropy including infinite entropy for the infinite-dimensional systems are established, and then, applied to compare the entropy exchange with the entropy change.

  6. Micro tube heat exchangers for Space Project (United States)

    National Aeronautics and Space Administration — Mezzo fabricates micro tube heat exchangers for a variety of applications, including aerospace, automotive racing, Department of Defense ground vehicles, economizers...

  7. Foreign Exchange Risk in International Transactions

    Directory of Open Access Journals (Sweden)

    Florentina-Olivia Balu


    In this article we will focus on forward and futures contracts for managing foreign exchange risk. A forward is a contract to buy or sell currency at an agreed upon exchange rate at a specific date in the future. Futures are similar to forwards except that they’re traded on exchanges which specify settlement dates. Also we make some recommendations related to the foreign exchange risk-management practices that are useful for companies involved in international trade and for financial institutions interested in providing hedging products to these companies.

  8. Data Exchange Management Information System (DEMIS) (United States)

    Social Security Administration — DEMIS combines a database (Operational Data Store - ODS) of data exchange-related Management Information (MI) with the agency's querying and reporting utility, the...

  9. Health and sexual behaviour among exchange students. (United States)

    Petersson, Carina; Peterson, Ulla; Swahnberg, Katarina; Oscarsson, Marie


    The objective was to describe the exchange students' health and sexual behaviour associated with their exchange studies, and examine the extent to which they had received preventive efforts against human immunodeficiency virus (HIV)/sexually transmitted infection (STI) and safer sex before departure. A cross-sectional study was conducted based on a web survey with questions about sexual behaviour, self-esteem and psychological well-being. Data were analysed using descriptive and analytical statistics. A total of 136 outgoing exchange students from a Swedish University participated. Most of the exchange students rated their health as good, had psychological well-being and rated their self-esteem as being high. Approximately half of the exchange students had sex with a new partner during the exchange semester, and 87% of them had sexually risky behaviour. More than half (61%) of the exchange students had received preventive efforts before departure. No statistically significant difference regarding preventive information was found between those who reported sexually risky behaviour and those who did not. The group that had sexually risky behaviour desired free condoms and access to clinics for sexual health. CONCLUSIONS EXCHANGE STUDENTS RATED THEIR HEALTH AS GOOD, AND THE MAJORITY OF THEM PARTICIPATED IN INFORMATION SESSIONS THAT ADDRESSED PREVENTIVE EFFORTS ON HIV/STI AND SAFER SEX BEFORE DEPARTURE SEXUALLY RISKY BEHAVIOUR DURING EXCHANGE STUDIES WAS REPORTED AND HIGHLIGHTS THE NEED FOR MORE EFFECTIVE PREVENTIVE MEASURES; FOR EXAMPLE, A RECOLLECTION OF READING STI INFORMATION. © Author(s) 2016.

  10. Exchange effects in a cold plasma

    CERN Document Server

    Ekman, Robin; Brodin, Gert


    We have studied the exchange corrections to linear electrostatic wave propagation in a plasma using a quantum kinetic formalism. Specifically we have considered the zero temperature limit. In order to simplify the calculations we have focused on the long wavelength limit, i.e. wavelengths much longer than the de Broglie wavelength. For the case of ion-acoustic waves we have calculated the exchange correction both to the damping rate and the real part of the frequency. For Langmuir waves the frequency shift due to exchange effects is found. Our results are compared with the frequency shifts deduced from commonly used exchange potentials which are computed from density functional theory.

  11. Algorithms for Lightweight Key Exchange. (United States)

    Alvarez, Rafael; Caballero-Gil, Cándido; Santonja, Juan; Zamora, Antonio


    Public-key cryptography is too slow for general purpose encryption, with most applications limiting its use as much as possible. Some secure protocols, especially those that enable forward secrecy, make a much heavier use of public-key cryptography, increasing the demand for lightweight cryptosystems that can be implemented in low powered or mobile devices. This performance requirements are even more significant in critical infrastructure and emergency scenarios where peer-to-peer networks are deployed for increased availability and resiliency. We benchmark several public-key key-exchange algorithms, determining those that are better for the requirements of critical infrastructure and emergency applications and propose a security framework based on these algorithms and study its application to decentralized node or sensor networks.

  12. Monetary Exchange with Multilateral Matching

    DEFF Research Database (Denmark)

    Julien, Benoît; Kennes, John; King, Ian

    This paper analyzes monetary exchange in a search model allowing for multilateral matches to be formed, according to a standard urn-ballprocess. We consider three physical environments: indivisible goods and money, divisible goods and indivisible money, and divisible goods and money. We compare....... In particular, surplus maximization can be achieved in this setting, in equilibrium, with a positive money supply. Moreover, with flexible prices and directed search, the first best allocation can be attained through price posting or through auctions with lotteries, but not through auctions without lotteries....... Finally, analysis of the case of divisible goods and money can be performed without the assumption of large families (as in Shi (1997)) or the day and night structure of Lagos and Wright (2005)....

  13. Educational Exchanges Across the Equator (United States)

    Norman, D. J.; Walker, C. E.; Smith, M.; Pompea, S. M.; Orellana, D.


    What is color? What is light? How can we use a spectrometer to help students understand the answers to these questions? Even half a world apart and between people of different languages and cultures, how to teach these ideas to students can be a lively subject for discussion. And it is! Aided by Internet 2-based videoconferencing, NOAO North and South have sponsored three teacher professional development videoconference workshops, dubbed ASTRO-Chile, linking teachers in Tucson, AZ, and La Serena, Chile. The teachers exchange methods and ideas about how to explain and demonstrate physical concepts, important to the study of astronomy, to students of various ages. The workshops are conducted in Spanish with four bilingual science teachers from the Tucson area discussing pedagogical approaches with their teaching counterparts in Chile. Demonstrations and project presentations, from both sites, are included as part of each workshop. This work is supported, in part, through funding from the NSF Astronomy and Astrophysics Postdoctoral Fellowship.

  14. Exchanger system for anhydrite pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Penet, A.


    This paper deals with the problem of roadway behaviour affecting airways, bottom roads and top roads in advancing faces in the HBNPC area. The support work in these zones used to be undertaken manually and involved a lot of man hours. These operations are now mechanized in the form of pneumatic stowing with anhydrite. The latter is delivered by pipeline using compressed air. The 'exchanger' is a sort of branching system in the pipeline enabling the flow to be switched from the top end of the face to the bottom end and vice versa (diagram). The associated operations can be undertaken with ease. The effect the system has on costs will soon be known. (In French)

  15. Exchange Rate Policy in Morocco and Persistence of Real Exchange Rate Misalignments

    National Research Council Canada - National Science Library

    Mohamed Bouzahzah; Radouane Bachar


    .... The objective of this article is to highlight the persistent nature of misalignments of the real exchange rate of the Dirham, especially since the adoption by Morocco of a policy exchange rate based...

  16. Employees' goal orientations, the quality of leader-member exchange, and the outcomes of job performance and job satisfaction

    NARCIS (Netherlands)

    Janssen, O.; Van Yperen, N.W.

    As hypothesized, data from 170 employees of a Dutch firm showed that the quality of leader-member exchange mediated positive relationships between a mastery orientation and leader-rated in-role job performance, leader-rated innovative job performance, and job satisfaction. In contrast, a performance

  17. 76 FR 25774 - Determination of Foreign Exchange Swaps and Foreign Exchange Forwards Under the Commodity... (United States)


    ... exchange derivatives, such as foreign exchange options, currency swaps, or non-deliverable forwards (``NDFs... markets for derivative instruments. In general, the payment obligations on currency swaps, interest rate... derivatives. Foreign exchange options, currency swaps, and NDFs may not be exempted from the CEA's definition...

  18. Interest Rate Rules, Exchange Market Pressure, and Successful Exchange Rate Management

    NARCIS (Netherlands)

    Klaassen, F.; Mavromatis, K.


    Central banks with an exchange rate objective set the interest rate in response to what they call ''pressure.'' Instead, existing interest rate rules rely on the exchange rate minus its target. To stay closer to actual policy, we introduce a rule that uses exchange market pressure (EMP), the

  19. Australian Universities' Strategic Goals of Student Exchange and Participation Rates in Outbound Exchange Programmes (United States)

    Daly, Amanda; Barker, Michelle


    International student exchange programmes are acknowledged as one aspect of a broader suite of internationalisation strategies aimed at enhancing students' intercultural understanding and competence. The decision to participate in an exchange programme is dependent on both individual and contextual factors such as student exchange policies and…

  20. Exchange Studies as Actor-Networks: Following Korean Exchange Students in Swedish Higher Education (United States)

    Ahn, Song-ee


    This article explores how Korean exchange students organized their studies during exchange programs in Swedish higher education. For most students, the programs became a disordered period in relation to their education. The value of exchange studies seems mainly to be extra-curricular. Drawing upon actor network theory, the article argues that the…

  1. 77 FR 24752 - Self-Regulatory Organizations; EDGA Exchange, Inc.; EDGX Exchange, Inc.; International Securities... (United States)


    ... COMMISSION [Release No. 34-66834; File Nos. SR-EDGA-2012-08; SR-EDGX-2012-07; SR- ISE-2012-21] Self... Exchange AG Will Transfer Its Interest in ISE Holdings, Inc. to a Newly Formed Swiss Corporation, Eurex... (``EDGA''), EDGX Exchange, Inc. (``EDGX''), International Securities Exchange, LLC (``ISE'' and, with EDGA...

  2. Making work safer: testing a model of social exchange and safety management. (United States)

    DeJoy, David M; Della, Lindsay J; Vandenberg, Robert J; Wilson, Mark G


    This study tests a conceptual model that focuses on social exchange in the context of safety management. The model hypothesizes that supportive safety policies and programs should impact both safety climate and organizational commitment. Further, perceived organizational support is predicted to partially mediate both of these relationships. Study outcomes included traditional outcomes for both organizational commitment (e.g., withdrawal behaviors) as well as safety climate (e.g., self-reported work accidents). Questionnaire responses were obtained from 1,723 employees of a large national retailer. Using structural equation modeling (SEM) techniques, all of the model's hypothesized relationships were statistically significant and in the expected directions. The results are discussed in terms of social exchange in organizations and research on safety climate. Maximizing safety is a social-technical enterprise. Expectations related to social exchange and reciprocity figure prominently in creating a positive climate for safety within the organization. Copyright 2010 Elsevier Ltd. All rights reserved.

  3. A social exchange-based model of the antecedents of workplace exclusion. (United States)

    Scott, Kristin L; Restubog, Simon Lloyd D; Zagenczyk, Thomas J


    We conducted 2 studies of coworker dyads to test a theoretical model exploring why and under what circumstances employees are the targets of workplace exclusion. Adopting a victim precipitation perspective, we integrate belongingness and social exchange theories to propose that employees who display workplace incivility are distrusted and therefore are targets of workplace exclusion. Highlighting the importance of the context of the perpetrator-target relationship, we also find support for the postulation that this mediated relationship is strengthened when the target employee is perceived to be a weak exchange partner and is attenuated when he or she is viewed as a valuable exchange partner. Theoretical and practical implications are discussed. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  4. Applied mediation analyses

    DEFF Research Database (Denmark)

    Lange, Theis; Hansen, Kim Wadt; Sørensen, Rikke


    In recent years, mediation analysis has emerged as a powerful tool to disentangle causal pathways from an exposure/treatment to clinically relevant outcomes. Mediation analysis has been applied in scientific fields as diverse as labour market relations and randomized clinical trials of heart...



    Mark Kunze; James Phillips


    This research investigated employees’ psychological dispositions of positive affect, negative affect, and cynicism as potential influences upon their perceptions of psychological contract fulfillment or violation. Leader-member exchange (LMX) was hypothesized to serve as a partial mediator of the relationship. Prior research has focused mainly on direct relationships between various personality variables and either LMX or psychological contract violation; none have yet examined LMX as a pot...

  6. A Rare case of Guillain-Barré syndrome in pregnancy treated with plasma exchange

    Directory of Open Access Journals (Sweden)

    Rahul Vasudev


    Full Text Available Guillain-Barre syndromé (GBS is an autoimmune disorder. It is rare in pregnancy as there is a decrease in cell-mediated immunity. A case of 28-year-old pregnant woman who presented with acute flaccid quadriplegia suffering from GBS is discussed in this study. She was treated with plasma exchange in her immediate post-partum period. The management of GBS in pregnancy has been discussed.

  7. Heat Exchanger Lab for Chemical Engineering Undergraduates (United States)

    Rajala, Jonathan W.; Evans, Edward A.; Chase, George G.


    Third year chemical engineering undergraduate students at The University of Akron designed and fabricated a heat exchanger for a stirred tank as part of a Chemical Engineering Laboratory course. The heat exchanger portion of this course was three weeks of the fifteen week long semester. Students applied concepts of scale-up and dimensional…

  8. Assessing heat exchanger performance data using temperature ...

    African Journals Online (AJOL)

    To ensure operation of heat exchangers, the goal is to verify that the exchanger is performing, or will perform, at its design. This is especially relevant to coolers that typically operate at heat loads reduced from their design basis. In addition, any calculated performance acceptance criteria must also consider uncertainty and ...

  9. Identifying the weights in exchange market pressure

    NARCIS (Netherlands)

    Klaassen, F.


    Exchange market pressure (EMP) measures the pressure on a currency to depreciate, and it is particularly relevant in crisis periods. EMP adds to the actual depreciation a weighted combination of policy instruments used to ward off depreciation, such as interest rates and foreign exchange

  10. The Story of Foreign Trade and Exchange. (United States)

    Fan, Cedric

    This comic-style booklet is one of a series of educational booklets published by the Federal Reserve Bank of New York. The booklet uses everyday language and lively illustrations to explain the benefits of international trade; the effects of tariffs and quotas; the significance of foreign exchange rates; how the foreign exchange market facilities…

  11. Timing matters in foreign exchange markets (United States)

    Hirata, Yoshito; Aihara, Kazuyuki


    We show using nonlinear time series analysis that the timing of trades in foreign exchange markets has significant information. We apply a set of methods for analyzing point process data developed in neuroscience and nonlinear science. Our results imply that foreign exchange markets might be chaotic and have short-term predictability.

  12. Individual Differences in Reactions to Inequitable Exchanges. (United States)

    Ellis, Barbara B.; Penner, Louis A.


    Investigates the role of sociopathic tendencies in reactions to inequitable exchanges in 273 males and females classified as high or low in sociopathy. Subjects read narratives of inequitable exchanges and assumed the role of the exploiter and the role of the victim in each. (Author/RH)

  13. Synthesis, characterization and ion exchange properties of ...

    Indian Academy of Sciences (India)

    The material has been characterized on the basis of chemical composition, pH titration, Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis. The effect on the exchange capacity of drying the exchanger at different temperatures has been studied. The analytical importance of the material has been ...

  14. 22 CFR 41.62 - Exchange visitors. (United States)


    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exchange visitors. 41.62 Section 41.62 Foreign Relations DEPARTMENT OF STATE VISAS VISAS: DOCUMENTATION OF NONIMMIGRANTS UNDER THE IMMIGRATION AND... intends to participate, in an exchange visitor program designated by the Bureau of Education and Cultural...

  15. Intersite Coulomb interaction and Heisenberg exchange

    NARCIS (Netherlands)

    Eder, R; van den Brink, J.; Sawatzky, G.A


    Based on exact diagonalization results for small clusters we discuss the effect of intersite Coulomb repulsion in Mott-Hubbard or charge transfers insulators. Whereas the exchange constant J for direct exchange is enhanced by intersite Coulomb interaction, that for superexchange is suppressed. The

  16. Exchange Rate Deregulation and Industrial Performance: An ...

    African Journals Online (AJOL)

    The study found that a long-run relationship exists between the industrial productivity growth rate, ration of industrial production to gross domestic product, exchange rate, interest rate and terms of trade, and that exchange rate deregulation has significant impact on industrial performance. In order to determine the short term ...

  17. Are Student Exchange Programs Worth It? (United States)

    Messer, Dolores; Wolter, Stefan C.


    The number of university students participating in exchange programs has risen sharply over the last decade. A survey of Swiss university graduates (classes of 1999 and 2001) shows that participation in student exchange programs depends significantly on the socio-economic background of students. We further analyze whether the participants benefit…

  18. 76 FR 33993 - Exchange Visitor Program (United States)


    ... due to this employment and accordingly, such students will be deemed to be in valid J-1 Exchange... Part 62 RIN 1400-ZA20 Exchange Visitor Program AGENCY: Department of State. ACTION: Notice of... Libyan students. This action is necessary to mitigate the adverse impact upon these students due to...

  19. Pan-American Teletandem Language Exchange Project (United States)

    Castillo-Scott, Aurora


    This paper describes a TeleTandem language exchange project between English speaking Spanish students at Georgia College, USA, and Spanish speaking English students at Universidad de Concepción, Chile. The aim of the project was to promote linguistic skills and intercultural competence through a TeleTandem exchange. Students used Skype and Google…

  20. Ion exchange in the nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Bibler, J.P.


    Ion exchange is used in nearly every part of the nuclear fuel cycle -- from the purification of uranium from its ore to the final recovery of uranium and transmutation products. Ion exchange also plays a valuable role in the management of nuclear wastes generated in the fuel cycle.

  1. Ion exchange in the nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Bibler, J.P.


    Ion exchange is used in nearly every part of the nuclear fuel cycle -- from the purification of uranium from its ore to the final recovery of uranium and transmutation products. Ion exchange also plays a valuable role in the management of nuclear wastes generated in the fuel cycle.

  2. Staff Exchange or Legal Alien Programs

    DEFF Research Database (Denmark)

    Jørgensen, Rune Nørgaard


    SRA would very much like to support the exchange of best practice between members throughout the year and the Membership Committee is presently looking into the opportunities for a Staff Exchange or Legal Alien Program. However the International Section has already had the chance to provide...

  3. Synthesis, characterization and ion exchange properties of ...

    Indian Academy of Sciences (India)

    zirconium(IV) oxychloride. Its ion exchange capacity for Na+ and K+ was found to be 2⋅20 and 2⋅35 meq g–1 dry exchanger, respectively. The material has been characterized on the basis of chemical composition, pH titration, Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis. The effect on the.

  4. Anion exchange membrane design for reverse electrodialysis

    NARCIS (Netherlands)

    Güler, E.


    Reverse electrodialysis (RED) is a clean, sustainable technology for the generation of energy from the mixing of solutions with different salinity. The ion exchange membranes are key elements in RED. Especially the study of anion exchange membranes is crucial since limited research has been done

  5. Microsoft Exchange Server PowerShell cookbook

    CERN Document Server

    Andersson, Jonas


    This book is for messaging professionals who want to build real-world scripts with Windows PowerShell 5 and the Exchange Management Shell. If you are a network or systems administrator responsible for managing and maintaining Exchange Server 2013, you will find this highly useful.

  6. Health information exchange among US hospitals. (United States)

    Adler-Milstein, Julia; DesRoches, Catherine M; Jha, Ashish K


    To determine the proportion of US hospitals engaged in health information exchange (HIE) with unaffiliated providers and to identify key hospital-level and market-level factors associated with participating in exchange. Using the 2009 American Hospital Association Information Technology survey, supplemented by Dartmouth Atlas, Area Resource File, and other national data, we examined which hospitals participated in regional efforts to electronically exchange clinical data. We used logistic regression models to determine hospital-level characteristics and market-level characteristics associated with hospitals' likelihood of participating in HIE. We found that 10.7% of US hospitals engaged in HIE with unaffiliated providers. In communities where exchange occurred, for-profit hospitals and those with a small market share were far less likely to engage in HIE than nonprofit hospitals or those with a larger market share. Hospitals in more concentrated markets were more likely to exchange and hospitals in markets with higher Medicare spending were less likely to exchange. At the start of implementation of the Health Information Technology for Economic and Clinical Health (HITECH) Act, only a small minority of US hospitals electronically exchange clinical data with unaffiliated providers. Health information exchange is a key part of reforming the healthcare system, and factors related to competitiveness may be holding some providers back.

  7. Music, radio and mediatization

    DEFF Research Database (Denmark)

    Michelsen, Morten; Krogh, Mads


    Mediatization has become a key concept for understanding the relations between media and other cultural and social fields. Contributing to the discussions related to the concept of mediatization, this article discusses how practices of radio and music(al life) influence each other. We follow Deacon......’s and Stanyer’s advice to supplement the concept of mediatization with ‘a series of additional concepts at lower levels of abstraction’ and suggest, in this respect, the notion of heterogeneous milieus of music–radio. Hereby, we turn away from the all-encompassing perspectives related to the concept...... of mediatization where media as such seem to be ascribed agency. Instead, we consider historical accounts of music–radio in order to address the complex nonlinearity of concrete processes of mediatization as they take place in the multiple meetings between a decentred notion of radio and musical life....

  8. Exchange fluctuation theorem for correlated quantum systems. (United States)

    Jevtic, Sania; Rudolph, Terry; Jennings, David; Hirono, Yuji; Nakayama, Shojun; Murao, Mio


    We extend the exchange fluctuation theorem for energy exchange between thermal quantum systems beyond the assumption of molecular chaos, and describe the nonequilibrium exchange dynamics of correlated quantum states. The relation quantifies how the tendency for systems to equilibrate is modified in high-correlation environments. In addition, a more abstract approach leads us to a "correlation fluctuation theorem". Our results elucidate the role of measurement disturbance for such scenarios. We show a simple application by finding a semiclassical maximum work theorem in the presence of correlations. We also present a toy example of qubit-qudit heat exchange, and find that non-classical behaviour such as deterministic energy transfer and anomalous heat flow are reflected in our exchange fluctuation theorem.

  9. Pseudo exchange bias due to rotational anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Ehrmann, A., E-mail: [Faculty of Engineering and Mathematics, Bielefeld University of Applied Sciences, 33619 Bielefeld (Germany); Komraus, S.; Blachowicz, T.; Domino, K. [Institute of Physics – Center for Science and Education, Silesian University of Technology, 44-100 Gliwice (Poland); Nees, M.K.; Jakobs, P.J.; Leiste, H. [Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany); Mathes, M.; Schaarschmidt, M. [ACCESS e. V., 57072 Aachen (Germany)


    Ferromagnetic nanostructure arrays with particle dimensions between 160 nm and 400 nm were created by electron-beam lithography. The permalloy structures consist of rectangular-shaped walls around a square open space. While measuring their magnetic properties using the Magneto-Optical Kerr Effect (MOKE), in some angular regions an exchange bias (EB) seemed to appear. This paper gives an overview of possible reasons for this “pseudo exchange bias” and shows experimentally and by means of micromagnetic simulations that this effect can be attributed to unintentionally measuring minor loops. - Highlights: • Pseudo exchange bias can be found in square Py nanorings of different dimensions. • Pseudo exchange bias stems from unintentionally measuring minor loops. • New approach in explaining “real” exchange bias effect in coupled FM/AFM systems. • Theoretical base to explain other measurements of a rotational anisotropy.

  10. Fertility as a process of social exchange

    Directory of Open Access Journals (Sweden)

    Patrick Heady


    Full Text Available By marrying and raising children, parents participate in a system of gift-exchange in which the gifts in question are human lives, and the parties to the exchange are the kinship groups recognised in the society concerned. Fertility reflects the attitudes of prospective parents to their place in the existing system of reproductive exchange, and the relationships of cooperation and authority which it implies - as well as their confidence in the system's continuing viability. It is shown that this view is compatible with earlier ideas about self-regulating population systems - and that changing economic circumstances are an important source of discrepancy between existing exchange systems and the attitudes and expectations of prospective parents. The discussion is developed with reference to data on European societies, including a case-study from the Alps, and concludes with an assessment of the relevance of the anthropological theory of gift exchange to contemporary fertility patterns in Europe and beyond.

  11. Can Leader–Member Exchange Contribute to Safety Performance in An Italian Warehouse? (United States)

    Mariani, Marco G.; Curcuruto, Matteo; Matic, Mirna; Sciacovelli, Paolo; Toderi, Stefano


    Introduction: The research considers safety climate in a warehouse and wants to analyze the Leader–Member Exchange (LMX) role in respect to safety performance. Griffin and Neal’s safety model was adopted and Leader-Member Exchange was inserted as moderator in the relationships between safety climate and proximal antecedents (motivation and knowledge) of safety performance constructs (compliance and participation). Materials and Methods: Survey data were collected from a sample of 133 full-time employees in an Italian warehouse. The statistical framework of Hayes (2013) was adopted for moderated mediation analysis. Results: Proximal antecedents partially mediated the relationship between Safety climate and safety participation, but not safety compliance. Moreover, the results from the moderation analysis showed that the Leader–Member Exchange moderated the influence of safety climate on proximal antecedents and the mediation exist only at the higher level of LMX. Conclusion: The study shows that the different aspects of leadership processes interact in explaining individual proficiency in safety practices. Practical Implications: Organizations as warehouses should improve the quality of the relationship between a leader and a subordinate based upon the dimensions of respect, trust, and obligation for high level of safety performance. PMID:28553244

  12. Can Leader–Member Exchange Contribute to Safety Performance in An Italian Warehouse?

    Directory of Open Access Journals (Sweden)

    Marco G. Mariani


    Full Text Available Introduction: The research considers safety climate in a warehouse and wants to analyze the Leader–Member Exchange (LMX role in respect to safety performance. Griffin and Neal’s safety model was adopted and Leader-Member Exchange was inserted as moderator in the relationships between safety climate and proximal antecedents (motivation and knowledge of safety performance constructs (compliance and participation.Materials and Methods: Survey data were collected from a sample of 133 full-time employees in an Italian warehouse. The statistical framework of Hayes (2013 was adopted for moderated mediation analysis.Results: Proximal antecedents partially mediated the relationship between Safety climate and safety participation, but not safety compliance. Moreover, the results from the moderation analysis showed that the Leader–Member Exchange moderated the influence of safety climate on proximal antecedents and the mediation exist only at the higher level of LMX.Conclusion: The study shows that the different aspects of leadership processes interact in explaining individual proficiency in safety practices.Practical Implications: Organizations as warehouses should improve the quality of the relationship between a leader and a subordinate based upon the dimensions of respect, trust, and obligation for high level of safety performance.

  13. Can Leader-Member Exchange Contribute to Safety Performance in An Italian Warehouse? (United States)

    Mariani, Marco G; Curcuruto, Matteo; Matic, Mirna; Sciacovelli, Paolo; Toderi, Stefano


    Introduction: The research considers safety climate in a warehouse and wants to analyze the Leader-Member Exchange (LMX) role in respect to safety performance. Griffin and Neal's safety model was adopted and Leader-Member Exchange was inserted as moderator in the relationships between safety climate and proximal antecedents (motivation and knowledge) of safety performance constructs (compliance and participation). Materials and Methods: Survey data were collected from a sample of 133 full-time employees in an Italian warehouse. The statistical framework of Hayes (2013) was adopted for moderated mediation analysis. Results: Proximal antecedents partially mediated the relationship between Safety climate and safety participation, but not safety compliance. Moreover, the results from the moderation analysis showed that the Leader-Member Exchange moderated the influence of safety climate on proximal antecedents and the mediation exist only at the higher level of LMX. Conclusion: The study shows that the different aspects of leadership processes interact in explaining individual proficiency in safety practices. Practical Implications: Organizations as warehouses should improve the quality of the relationship between a leader and a subordinate based upon the dimensions of respect, trust, and obligation for high level of safety performance.

  14. Nutrient Exchange and Regulation in Arbuscular Mycorrhizal Symbiosis. (United States)

    Wang, Wanxiao; Shi, Jincai; Xie, Qiujin; Jiang, Yina; Yu, Nan; Wang, Ertao


    Most land plants form symbiotic associations with arbuscular mycorrhizal (AM) fungi. These are the most common and widespread terrestrial plant symbioses, which have a global impact on plant mineral nutrition. The establishment of AM symbiosis involves recognition of the two partners and bidirectional transport of different mineral and carbon nutrients through the symbiotic interfaces within the host root cells. Intriguingly, recent discoveries have highlighted that lipids are transferred from the plant host to AM fungus as a major carbon source. In this review, we discuss the transporter-mediated transfer of carbon, nitrogen, phosphate, potassium and sulfate, and present hypotheses pertaining to the potential regulatory mechanisms of nutrient exchange in AM symbiosis. Current challenges and future perspectives on AM symbiosis research are also discussed. Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.

  15. 40 CFR 63.654 - Heat exchange systems. (United States)


    ... any one of the criteria in paragraphs (b)(1) through (2) of this section. (1) All heat exchangers that... any heat exchangers that are in organic HAP service as defined in this subpart). (c) The owner or... each heat exchanger exit line for each heat exchanger or group of heat exchangers in organic HAP...

  16. 40 CFR 63.1409 - Heat exchange system provisions. (United States)


    ... locations where the cooling water enters and exits each heat exchanger or any combination of heat exchangers.... (iii) For samples taken at the entrance and exit of each heat exchanger or any combination of heat exchangers, the entrance is the point at which the cooling water enters the individual heat exchanger or...

  17. 17 CFR 229.802 - Exchange Act industry guides. (United States)


    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Exchange Act industry guides. 229.802 Section 229.802 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD... AND CONSERVATION ACT OF 1975-REGULATION S-K List of Industry Guides § 229.802 Exchange Act industry...

  18. The European-American exchange. (United States)

    Guerra, F


    The European-American exchange of infectious diseases was responsible for the demographic havoc of the native population in the New World after 1492. Prior to this date medical writers describe the presence in Spain of viral diseases like influenza, parotitis, smallpox, measles, poliomyelitis, and rabies; there were also rickettsiasis, diphtheria, salmonellosis, plague, tubercolosis, leprosy, malaria, scabies and tinea. In America, before European arrivals, there were no records of human viral diseases, though there were records of rickettsiasis, treponematosis--pinta, yaws and syphilis--leihsmaniasis, amibiasis and perhaps leprosy. With the discovery of America in 1492, Columbus's sailors were contaminated by yaws and spread this disease into Europe. In 1493 influenza, as a zoonosis, was introduced into Santo Domingo and was responsible for the annihilation of the natives of the Antilles in less than a quarter of a century; in 1518 smallpox was also introduced in Santo Domingo and then to the American continent by negro slaves: by the same means measles were introduced in 1531. The previous existence or introduction of other infectious diseases in America is also discussed.

  19. Therapeutic plasma exchange in Casablanca. (United States)

    Tazi, I; Merimi, F; Majd, A; Benchemsi, N


    Therapeutic plasma exchange (TPE) is an extracorporeal blood purification method for the treatment of diseases in which pathological proteins have to be eliminated. In the aim to demonstrate our single center activity, we analyzed our data since 2 years. Between years 2002 and 2005, 104 TPE procedures were performed on 42 patients. Median age and male/female ratio were 32 (range, 17-56) and 24/18, respectively. Departments those referred the majority of the TPE were neurology (n=32), nephrology (n=5) and intensive care unit (n=5). The most common indications were: polyradiculoneuropathies (53%), myasthenia gravis (17%) and Guillain-Barré syndrome (12%). The median TPE procedure per patient was 2.3 (range, 1-10). In the majority of patients, vascular access was provided by puncture of two large, durable peripheral antecubital veins. The procedures were performed with the "Haemonetic Ultralight" discontinuous flow cell separator devices. Citrate solution was used as an anticoagulant in all cases. The substitution fluids most often used in our unit are Albumin 20% solution (92 times), Albumin 4% (10 times) and fresh frozen plasma (twice). Seventy five percent of the patients showed improvement, 7% remained the same and 18% worsened. Thirteen adverse reactions were recorded. The creation of a national registry by the local society is a vital move to improve TPE practice in our country.

  20. The interplanetary exchange of photosynthesis. (United States)

    Cockell, Charles S


    Panspermia, the transfer of organisms from one planet to another, either through interplanetary or interstellar space, remains speculation. However, its potential can be experimentally tested. Conceptually, it is island biogeography on an interplanetary or interstellar scale. Of special interest is the possibility of the transfer of oxygenic photosynthesis between one planet and another, as it can initiate large scale biospheric productivity. Photosynthetic organisms, which must live near the surface of rocks, can be shown experimentally to be subject to destruction during atmospheric transit. Many of them grow as vegetative cells, which are shown experimentally to be susceptible to destruction by shock during impact ejection, although the effectiveness of this dispersal filter can be shown to be mitigated by the characteristics of the cells and their local environment. Collectively these, and other, experiments reveal the particular barriers to the cross-inoculation of photosynthesis. If oxygen biosignatures are eventually found in the atmospheres of extrasolar planets, understanding the potential for the interplanetary exchange of photosynthesis will aid in their interpretation.

  1. Update of CERN exchange network

    CERN Multimedia


    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Date Change type Affected areas March 26 Update of the voice messaging system All CERN sites April...

  2. Update of CERN exchange network

    CERN Multimedia


    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to Date Change type Affected areas April 8 Update of switch in LHC 7 LHC 7 Point April 9 Update of...

  3. Update of CERN exchange network

    CERN Multimedia


    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). In addition, the voice messaging system will be shut down on March, 26th April from 18:00 to 00:00. Calls supposed to be routed to the voice messaging system will not be possible during the shutdown. CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to DateChange typeAffected areas March 26Update of the voice messaging systemAll CERN sites April 4Updat...

  4. Update of CERN exchange network

    CERN Multimedia


    An update of the CERN exchange network will be done next April. Disturbances or even interruptions of telephony services may occur from 4th to 24th April during evenings from 18:30 to 00:00 but will not exceed more than 4 consecutive hours (see tentative planning below). CERN divisions are invited to avoid any change requests (set-ups, move or removals) of telephones and fax machines from 4th to 25th April. Everything will be done to minimize potential inconveniences which may occur during this update. There will be no loss of telephone functionalities. CERN GSM portable phones won't be affected by this change. Should you need more details, please send us your questions by email to DateChange typeAffected areas April 11 Update of switch in LHC 4 LHC 4 Point April 14 Update of switch in LHC 5 LHC 5 Point April 15 Update of switches in LHC 3 and LHC 2 Points LHC 3 and LHC 2 April 22 Update of switch N4 Meyrin Ouest April 23 Update of switch  N6 Prévessin Site Ap...

  5. A GTP-exchange factor required for cell orientation. (United States)

    Nern, A; Arkowitz, R A


    The Rho-family of GTPases and their regulators are essential for cytoskeletal reorganization and transcriptional activation in response to extracellular signals. Little is known about what links these molecules to membrane receptors. In the budding yeast Saccharomyces cerevisiae, haploid cells respond to mating pheromone through a G-protein-coupled receptor and the betagamma subunit of the G protein, resulting in arrest of the cell cycle, transcriptional activation, and polarized growth towards a mating partner. The Rho-family GTPase Cdc42 and its exchange factor Cdc24 have been implicated in the mating process, but their specific role is unknown. Here we report the identification of cdc24 alleles that do not affect vegetative growth but drastically reduce the ability of yeast cells to mate. When exposed to mating pheromone, these mutants arrest growth, activate transcription, and undergo characteristic morphological and actin-cytoskeleton polarization. However, the mutants are unable to orient towards a pheromone gradient, and instead position their mating projection adjacent to their previous bud site. The mutants are specifically defective in the binding of Cdc24 to the G-protein betagamma subunit. Our results demonstrate that the association of an exchange factor and the betagamma subunit of a hetero-trimeric G protein links receptor-mediated activation to oriented cell growth.

  6. Polyarene mediators for mediated redox flow battery

    Energy Technology Data Exchange (ETDEWEB)

    Delnick, Frank M.; Ingersoll, David; Liang, Chengdu


    The fundamental charge storage mechanisms in a number of currently studied high energy redox couples are based on intercalation, conversion, or displacement reactions. With exception to certain metal-air chemistries, most often the active redox materials are stored physically in the electrochemical cell stack thereby lowering the practical gravimetric and volumetric energy density as a tradeoff to achieve reasonable power density. In a general embodiment, a mediated redox flow battery includes a series of secondary organic molecules that form highly reduced anionic radicals as reaction mediator pairs for the reduction and oxidation of primary high capacity redox species ex situ from the electrochemical cell stack. Arenes are reduced to stable anionic radicals that in turn reduce a primary anode to the charged state. The primary anode is then discharged using a second lower potential (more positive) arene. Compatible separators and solvents are also disclosed herein.

  7. 75 FR 55381 - Joint Industry Plan; Order Approving Amendment To Add EDGA Exchange, Inc. and EDGX Exchange, Inc... (United States)


    ... COMMISSION Joint Industry Plan; Order Approving Amendment To Add EDGA Exchange, Inc. and EDGX Exchange, Inc... participants to the Joint-SRO Plan are the American Stock Exchange LLC (n/k/a NYSE Amex, Inc.), BATS Exchange... exchange or national securities association may become a party to the Plan by: (i) Executing a copy of the...

  8. Optimization of parameters of heat exchangers vehicles

    Directory of Open Access Journals (Sweden)

    Andrei MELEKHIN


    Full Text Available The relevance of the topic due to the decision of problems of the economy of resources in heating systems of vehicles. To solve this problem we have developed an integrated method of research, which allows to solve tasks on optimization of parameters of heat exchangers vehicles. This method decides multicriteria optimization problem with the program nonlinear optimization on the basis of software with the introduction of an array of temperatures obtained using thermography. The authors have developed a mathematical model of process of heat exchange in heat exchange surfaces of apparatuses with the solution of multicriteria optimization problem and check its adequacy to the experimental stand in the visualization of thermal fields, an optimal range of managed parameters influencing the process of heat exchange with minimal metal consumption and the maximum heat output fin heat exchanger, the regularities of heat exchange process with getting generalizing dependencies distribution of temperature on the heat-release surface of the heat exchanger vehicles, defined convergence of the results of research in the calculation on the basis of theoretical dependencies and solving mathematical model.

  9. High heat flux single phase heat exchanger (United States)

    Valenzuela, Javier A.; Izenson, Michael G.


    This paper presents the results obtained to date in a program to develop a high heat flux, single-phase heat exchanger for spacecraft thermal management. The intended application is a net generation interface heat exchanger to couple the crew module water thermal bus to the two-phase ammonia main thermal bus in the Space Station Freedom. The large size of the interface heat exchanger is dictated by the relatively poor water-side heat transfer characteristics. The objective of this program is to develop a single-phase heat transfer approach which can achieve heat fluxes and heat transfer coefficients comparable to those of the evaporation ammonia side. A new heat exchanger concept has been developed to meet these objecties. The main feature of this heat exchanger is that it can achieve very high heat fluxes with a pressure drop one to two orders of magnitude lower than those of previous microchannel or jet impingement high heat flux heat exchangers. This paper describes proof-of-concept experiments performed in air and water and presents analytical model of the heat exchanger.

  10. Ion Exchange Formation via Sulfonated Bicomponent Nonwovens (United States)

    Stoughton, Hannah L.

    For many years ion exchange resins were used to: remove heavy metals from water, recover materials from wastewater, and eliminate harmful gases from the air. While use of these resin beads dominates the ion exchange industry, the beads have limitations that should be considered when decisions are made to employ them. For instance, officials must balance the inherent zero sum surface area and porosity of the materials. This series of studies investigates the use of bicomponent nonwovens as a base substrate for producing high surface area ion exchange materials for the removal of heavy metal ions. Functionalized materials were produced in a two-step process: (1) PET/PE spunbond bicomponent fibers were fractured completely, producing the high surface area nonwoven to be used as the base ion exchange material, and (2) the conditions for functionalizing the PET fibers of the nonwoven webs were investigated where an epoxy containing monomer was grafted to the surface followed by sulfonation of the monomer. The functionalization reactions of the PET fibers were monitored based on: weight gain, FTIR, TOF-SIMS, and SEM. Ion exchange properties were evaluated using titration and copper ion removal capacity from test solutions. The relationship between web structure and removal efficiency of the metal ions was defined through a comparison of the bicomponent and homocomponent nonwovens for copper ion removal efficiency. The investigation revealed that utilizing the high surface area, fractured bicomponent nonwoven ion exchange materials with capacities comparable to commercially available ion exchange resins could be produced.

  11. Searching for an Appropriate Exchange Rate Regime

    Directory of Open Access Journals (Sweden)

    Yunjong Wang


    Full Text Available This paper attempts to survey current debates on the choice of exchange rate regime in emerging market economies. The issue of choosing an appropriate exchange rate regime is being actively discussed since the recent Asian crisis. As a lesson from the recent crises, one widely shared conclusion is that soft peg exchange rate regimes are extremely vulnerable in a world of volatile capital movements. Consequently, new orthodoxy based on the impossible trinity hypothesis favours two corner solutions ― greater flexibility or credible institutional assurance, like a currency board system or dollarization. Nevertheless, questions whether such corner solutions are adequate for developing countries are rising of late. "Fear of floating" is still conspicuous in many developing countries having adopted nominally a free-floating exchange rate regime. Developing countries are sensitive to exchange rate fluctuations because the cost of exchange rate volatility is greater than the benefit when compared to developed countries. Monitoring bands is a compromise solution, but it still needs further enhancement of estimation techniques for fundamental equilibrium exchange rates in order to make those estimation results more workable in practice. Other alternatives include the creation of soft peg of the G-3 currencies. Despite counterarguments, the stability of G-3 currencies could prove to be beneficial to emerging market economies.

  12. Tear exchange and contact lenses: a review. (United States)

    Muntz, Alex; Subbaraman, Lakshman N; Sorbara, Luigina; Jones, Lyndon


    Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the ocular surface and the lens. This exchange is considerably lower during the wear of soft lenses compared with rigid lenses. As a result, the accumulation of tear film debris and metabolic by-products between the cornea and a soft contact lens increases, potentially leading to complications. Lens design innovations have been proposed, but no substantial improvement in soft lens tear exchange has been reported. Researchers have determined post-lens tear exchange using several methods, notably fluorophotometry. However, due to technological limitations, little remains known about tear hydrodynamics around the lens and, to-date, true tear exchange with contact lenses has not been shown. Further knowledge regarding tear exchange could be vital in aiding better contact lens design, with the prospect of alleviating certain adverse ocular responses. This article reviews the literature to-date on the significance, implications and measurement of tear exchange with contact lenses. Copyright © 2014 Spanish General Council of Optometry. Published by Elsevier Espana. All rights reserved.

  13. Research of Spined Heat-Exchanging Pipes

    Directory of Open Access Journals (Sweden)

    Akulov Kirill


    Full Text Available Work is devoted to a research of spined heat-exchanging pipes that are assumed to use in air-cooler exchangers (ACE. The proposed new geometry of finning allows intensifying heat exchange and improving the efficiency of air coolers. It is caused by the increased area of finned surface with a value of finning ratio (the ratio of the area of the smooth pipe to a finned one to 42.7, while in the commercially available ACE, the figure is 22. Besides, the geometrical arrangement of the pin fins turbulizes the airflow. It should be mentioned that an easier method of manufacturing of heat exchanging pipes is proposed to use, which will reduce their costs. The proposed heat exchange pipes are made by winding cut aluminum strip to the supporting pipe or stretching stamped blanks on it. To increase the efficiency of the heat exchange surface pin fins should be as thin and long as possible; however, their strength should be sufficient for deformation-free operation. Fins should be staggered to maximize the distance between them. Spined heat-exchange pipes are designed to operate in a commercially produced ACE and their service is carried out similarly to commercially produced transversely finned pipes.

  14. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. (United States)

    Painter, Corrie A; Negroni, Maria P; Kellersberger, Katherine A; Zavala-Ruiz, Zarixia; Evans, James E; Stern, Lawrence J


    HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM binding affinity, weakened MHC-peptide hydrogen bonding as measured by hydrogen-deuterium exchange mass spectrometry, and increased susceptibility to DM-mediated peptide exchange. Structural analysis revealed a set of concerted conformational alterations at the N-terminal end of the peptide-binding site. These results suggest that interaction with HLA-DM is driven by a conformational change of the MHC II protein in the region of the α-subunit 3(10) helix and adjacent extended strand region, and provide a model for the mechanism of DM-mediated peptide exchange.

  15. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange (United States)

    Painter, Corrie A.; Negroni, Maria P.; Kellersberger, Katherine A.; Zavala-Ruiz, Zarixia; Evans, James E.; Stern, Lawrence J.


    HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM binding affinity, weakened MHC-peptide hydrogen bonding as measured by hydrogen-deuterium exchange mass spectrometry, and increased susceptibility to DM-mediated peptide exchange. Structural analysis revealed a set of concerted conformational alterations at the N-terminal end of the peptide-binding site. These results suggest that interaction with HLA-DM is driven by a conformational change of the MHC II protein in the region of the α-subunit 310 helix and adjacent extended strand region, and provide a model for the mechanism of DM-mediated peptide exchange. PMID:22084083

  16. Refractive outcomes after multifocal intraocular lens exchange. (United States)

    Kim, Eric J; Sajjad, Ahmar; Montes de Oca, Ildamaris; Koch, Douglas D; Wang, Li; Weikert, Mitchell P; Al-Mohtaseb, Zaina N


    To evaluate the refractive outcomes after multifocal intraocular lens (IOL) exchange. Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. Retrospective case series. Patients had multifocal IOL explantation followed by IOL implantation. Outcome measures included type of IOL, surgical indication, corrected distance visual acuity (CDVA), and refractive prediction error. The study comprised 29 patients (35 eyes). The types of IOLs implanted after multifocal IOL explantation included in-the-bag IOLs (74%), iris-sutured IOLs (6%), sulcus-fixated IOLs with optic capture (9%), sulcus-fixated IOLs without optic capture (9%), and anterior chamber IOLs (3%). The surgical indication for exchange included blurred vision (60%), photic phenomena (57%), photophobia (9%), loss of contrast sensitivity (3%), and multiple complaints (29%). The CDVA was 20/40 or better in 94% of eyes before the exchange and 100% of eyes after the exchange (P = .12). The mean refractive prediction error significantly decreased from 0.22 ± 0.81 diopter (D) before the exchange to -0.09 ± 0.53 D after the exchange (P < .05). The median absolute refractive prediction error significantly decreased from 0.43 D before the exchange to 0.23 D after the exchange (P < .05). Multifocal IOL exchange can be performed safely with good visual outcomes using different types of IOLs. A lower refractive prediction error and a higher likelihood of 20/40 or better vision can be achieved with the implantation of the second IOL compared with the original multifocal IOL, regardless of the final IOL position. Copyright © 2017 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  17. The Emerging Role of Guanine Exchange Factors in ALS and other neurodegenerative diseases

    Directory of Open Access Journals (Sweden)

    Cristian eDroppelmann


    Full Text Available Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide exchange factors (GEFs, of which two classes: Dbl-related exchange factors and the more recently described Dock family exchange factors. Increasingly, deregulation of normal GEF activity or function has been associated with a broad range of disease states, including neurodegeneration and neurodevelopmental disorders. In this review, we examine this evidence with special emphasis on the novel role of Rho guanine nucleotide exchange factor (RGNEF/p190RhoGEF in the pathogenesis of amyotrophic lateral sclerosis (ALS. RGNEF is the first neurodegeneration-linked GEF that regulates not only RhoA GTPase activation but also functions as an RNA binding protein that directly acts with low molecular weight neurofilament (NEFL mRNA 3’UTR to regulate its stability. This dual role for RGNEF, coupled with the increasing understanding of the key role for GEFs in modulating the GTPase function in cell survival suggests a prominent role for GEFs in mediating a critical balance between cytotoxicity and neuroprotection which, when disturbed, contributes to neuronal loss.

  18. Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange (United States)

    van Schie, Karin A.; Ooijevaar-de Heer, Pleuni; Dijk, Lisanne; Kruithof, Simone; Wolbink, Gertjan; Rispens, Theo


    Tumor necrosis factor (TNF) is a homotrimeric cytokine that is a key mediator of inflammation. It is unstable at physiological concentrations and slowly converts into an inactive form. Here, we investigated the mechanism of this process by using a Förster resonance energy transfer (FRET) assay that allowed monitoring of monomeric subunit exchange in time. We observed continuous exchange of monomeric subunits even at concentrations of TNF high enough to maintain its bioactivity. The kinetics of this process closely corresponds with the appearance of monomeric subunits and disappearance of trimeric TNF in time at ng/ml concentrations as monitored by high-performance size-exclusion chromatography (HP-SEC). Furthermore, of the five therapeutic TNF inhibitors that are currently used in the clinic, three (adalimumab, infliximab, etanercept) were found to completely inhibit the monomer exchange reaction and stabilize TNF trimers, whereas golimumab and certolizumab could not prevent monomer exchange, but did slow down the exchange process. These differences were not correlated with the affinities of the TNF inhibitors, measured with both surface plasmon resonance (SPR) and in fluid phase using fluorescence-assisted HP-SEC. The stabilizing effect of these TNF inhibitors might result in prolonged residual TNF bioactivity under conditions of incomplete blocking, as observed in vitro for adalimumab. PMID:27605058

  19. History of respiratory gas exchange. (United States)

    West, John B


    As early as the 6th century B.C. the Greeks speculated on a substance pneuma that meant breath or soul, and they argued that this was essential for life. An important figure in the 2nd century A.D. was Galen whose school developed an elaborate cardiopulmonary system that influenced scientific thinking for 1400 years. A key concept was that blood was mixed with pneuma from the lung in the left ventricle thus forming vital spirit. It was also believed that blood flowed from the right to the left ventricle of the heart through pores in the interventricular septum but this view was challenged first by the Arab physician Ibn al-Nafis in the 13th century and later by Michael Servetus in the 16th century. The 17th century saw an enormous burgeoning of knowledge about the respiratory gases. First Torricelli explained the origin of atmospheric pressure, and then a group of physiologists in Oxford clarified the properties of inspired gas that were necessary for life. This culminated in the work of Lavoisier who first clearly elucidated the nature of the respiratory gases, oxygen, carbon dioxide and nitrogen. At that time it was thought that oxygen was consumed in the lung itself, and the fact that the actual metabolism took place in peripheral tissues proved to be a very elusive concept. It was not until the late 19th century that the issue was finally settled by Pflüger. In the early 20th century there was a colorful controversy about whether oxygen was secreted by the lung. During and shortly after World War II, momentous strides were made on the understanding of pulmonary gas exchange, particularly the role of ventilation-perfusion inequality. A critical development in the 1960s was the introduction of blood gas electrodes, and these have transformed the management of patients with severe lung disease. © 2011 American Physiological Society.

  20. 76 FR 10353 - Locational Exchanges of Wholesale Electric Power (United States)


    ... Energy Regulatory Commission Locational Exchanges of Wholesale Electric Power AGENCY: Federal Energy... locational exchanges of electric power should be permitted generically and circumstances under which the... seeks comment regarding circumstances in which locational exchanges of electric power should be...

  1. Efficiency Tests in Foreign Exchange Market

    Directory of Open Access Journals (Sweden)

    Yi Hsien Lee


    Full Text Available The main purpose of the paper is applying filter rules to examine the efficiency of foreign exchange. This paper uses three strategies of filter rules (buy long, sell short, buy long and sell short strategies to test the performance of the transaction for EUR, JPY, GBP. The findings show that people will obtain more return by taking buy long/ sell short strategies of filter rules without considering transaction cost. However, the transaction of these three foreign exchange rate (EUR, JPY, GBP will be more efficient by considering transaction cost. The results imply the foreign exchange market is efficient for the EUR, JPY and GBP.

  2. Scaling analysis on Indian foreign exchange market (United States)

    Sarkar, A.; Barat, P.


    In this paper, we investigate the scaling behavior of the average daily exchange rate returns of the Indian Rupee against four foreign currencies: namely, US Dollar, Euro, Great Britain Pound and Japanese Yen. The average daily exchange rate return of the Indian Rupee against US Dollar is found to exhibit a persistent scaling behavior and follow Levy stable distribution. On the contrary, the average daily exchange rate returns of the other three foreign currencies do not show persistency or antipersistency and follow Gaussian distribution.

  3. Europlanet-2020 NA1 Exchange Program (United States)

    Genzer, M.; Szego, K.; Haukka, H.; Harri, A.-M.


    The task of Exchange Program of NA1 is to support the activities of EPN2020 with experts and scientific exchange whenever it is needed. Short visits (up to 1 week) with the goal of improving infrastructure facilities and services offered to the scientific community are supported from this task. Since the start of the EPN2020 in September 2015 we have received and approved 14 applications for exchange program travel. More general and specifically targeted calls are planned for the future. The calls are announced on Europlanet-2020 NA1 web site.

  4. Exchange students' motivations and language learning success

    DEFF Research Database (Denmark)

    Caudery, Tim; Petersen, Margrethe; Shaw, Philip

    in the host country. To what extent is this true when students plan to study in English in a non-English speaking country? Do they hope and expect to improve their English skills, their knowledge of the local language, both, or neither? to what extent are these expectations fulfilled? Results form the project......One point investigated in our research project on the linguistic experiences of exchange students in Denmark and Sweden is the reasons students have for coming on exchange. Traditionally, an important goal of student exchange was to acquire improved language skills usually in the language spoken...

  5. Microsoft Exchange Server 2013 high availability

    CERN Document Server

    Mota, Nuno


    This book is a hands-on practical guide that provides the reader with a number of clear scenarios and examples, making it easier to understand and apply the new concepts. Each chapter can be used as a reference, or it can be read from beginning to end, allowing consultants/administrators to build a solid and highly available Exchange 2013 environment. If you are a messaging professional who wants to learn to design a highly available Exchange 2013 environment, this book is for you. Although not a definite requirement, practical experience with Exchange 2010 is expected, without being a subject

  6. Fashion, Mediations & Method Assemblages

    DEFF Research Database (Denmark)

    Sommerlund, Julie; Jespersen, Astrid Pernille

    , 1997). "Mediation" is an activity rather than an actor; a co-constructive relation that creates what it mediates - the producer and the consumer. Hennion argues "that something effectively `happens´ in this process, which transforms the ways things were before" (Hennion & Grenier 2000, p. 346). Hennion...... to STS literature by expanding one of its central debates to a new empirical setting; fashion specifically, and the aesthetic-cultural field on a more general level. In trying to make a theoretical connection between aesthetics and sociality of fashion, the paper suggests the term of "mediator" (Hennion......, it is an important ambition of this paper to go into a methodological discussion of how "that which effectively happens" can be approached. To this end, the paper will combine Hennion's term of the "mediator" with John Laws methodological term of "method assemblages". Method assemblages is a suggested as a way...

  7. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.


    Implementation of new computer-mediated communication (CMC) systems in organizations is a complex socio-technical endeavour, involving the mutual adaptation of technology and organization over time. Drawing on the analytic concept of sensemaking, this paper provides a theoretical perspective...... that deepens our understanding of how organizations appropriate new electronic communication media. The paper analyzes how a group of mediators in a large, multinational company adapted a new web-based CMC technology (a virtual workspace) to the local organizational context (and vice versa) by modifying...... features of the technology, providing ongoing support for users, and promoting appropriate conventions of use. We found that these mediators exerted considerable influence on how the technology was established and used in the organization. The mediators were not neutral facilitators of a well...

  8. Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.

    Directory of Open Access Journals (Sweden)

    Jennifer E Kerr

    Full Text Available Porphyromonas gingivalis is a gram-negative anaerobic bacterium, a member of the human oral microbiome, and a proposed "keystone" pathogen in the development of chronic periodontitis, an inflammatory disease of the gingiva. P. gingivalis is a genetically diverse species, and is able to exchange chromosomal DNA between strains by natural competence and conjugation. In this study, we investigate the role of horizontal DNA transfer as an adaptive process to modify behavior, using the major fimbriae as our model system, due to their critical role in mediating interactions with the host environment. We show that P. gingivalis is able to exchange fimbrial allele types I and IV into four distinct strain backgrounds via natural competence. In all recombinants, we detected a complete exchange of the entire fimA allele, and the rate of exchange varies between the different strain backgrounds. In addition, gene exchange within other regions of the fimbrial genetic locus was identified. To measure the biological implications of these allele swaps we compared three genotypes of fimA in an isogenic background, strain ATCC 33277. We demonstrate that exchange of fimbrial allele type results in profound phenotypic changes, including the quantity of fimbriae elaborated, membrane blebbing, auto-aggregation and other virulence-associated phenotypes. Replacement of the type I allele with either the type III or IV allele resulted in increased invasion of gingival fibroblast cells relative to the isogenic parent strain. While genetic variability is known to impact host-microbiome interactions, this is the first study to quantitatively assess the adaptive effect of exchanging genes within the pan genome cloud. This is significant as it presents a potential mechanism by which opportunistic pathogens may acquire the traits necessary to modify host-microbial interactions.

  9. Determining the sign of exchange coupling in a chromia based perpendicular exchange bias heterostructure (United States)

    Singh, Uday; Street, Mike; Echtenkamp, Will; Binek, Christian; Adenwalla, Shireen

    Exchange bias arises from the coupling at the AFM/FM interface and, has been observed and studied in a wide range of systems. A key property of exchange bias systems is the sign of the coupling between the ferromagnet spins and the interfacial antiferromagnet spins, which may be aligned either ferromagnetically (parallel) or antiferromagnetically (antiparallel). Antiferromagnetic exchange coupling is known to be the generic cause of positive exchange bias. Determining the sign of exchange coupling is straight forward in system where the coupling is weak and can be overcome by Zeeman energy on field -cooling. It is, however, a challenging task when the available magnetic field is low or the magnitude of the exchange coupling is high. Here, we present a technique to determine the sign of the exchange coupling using low fields. We measure the exchange bias field as a function of ferromagnet magnetization during field cooling and the resultant behavior of the exchange bias vs. the magnetization uniquely determines the sign of the coupling. We use this to measure the sign of the exchange coupling in a Cr2O3(300 nm)/Pd(0.5 nm)/[Co(0.3 nm)/Pd(1 nm)]3 heterostructure thin film system and verify our results with the conventional high field method. This work was supported by the National Science Foundation (NSF) through Grant No. DMR-1409622 and the Nebraska Materials Research Science and Engineering Center (MRSEC) (Grant No. DMR-1420645).

  10. Transfer Rate Edited experiment for the selective detection of Chemical Exchange via Saturation Transfer (TRE-CEST). (United States)

    Friedman, Joshua I; Xia, Ding; Regatte, Ravinder R; Jerschow, Alexej


    Chemical Exchange Saturation Transfer (CEST) magnetic resonance experiments have become valuable tools in magnetic resonance for the detection of low concentration solutes with far greater sensitivity than direct detection methods. Accurate measures of rates of chemical exchange provided by CEST are of particular interest to biomedical imaging communities where variations in chemical exchange can be related to subtle variations in biomarker concentration, temperature and pH within tissues using MRI. Despite their name, however, traditional CEST methods are not truly selective for chemical exchange and instead detect all forms of magnetization transfer including through-space NOE. This ambiguity crowds CEST spectra and greatly complicates subsequent data analysis. We have developed a Transfer Rate Edited CEST experiment (TRE-CEST) that uses two different types of solute labeling in order to selectively amplify signals of rapidly exchanging proton species while simultaneously suppressing 'slower' NOE-dominated magnetization transfer processes. This approach is demonstrated in the context of both NMR and MRI, where it is used to detect the labile amide protons of proteins undergoing chemical exchange (at rates⩾30s(-1)) while simultaneously eliminating signals originating from slower (∼5s(-1)) NOE-mediated magnetization transfer processes. TRE-CEST greatly expands the utility of CEST experiments in complex systems, and in-vivo, in particular, where it is expected to improve the quantification of chemical exchange and magnetization transfer rates while enabling new forms of imaging contrast. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. When Memories are Mediated

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Bjerregaard, Mette


    that are mediated through stories: told and retold as oral stories through generations, as myths or sagas, or remediated as contemporary documentary film accounts or more fictional film accounts. In these processes of retelling acts of violence, transformations of meanings across time, cultural, social...... makes meaning about past events. In the discussion, we consider how mediated memories affect audiences, and the potential of achieving development of present political and cultural understandings of past acts of violence....





    At a time of global economic crisis followed by resource crisis, a period in which the world seeks alternative resources through eco-investment, environmental conflicts are inevitable. Romania is among the few countries that do not pay enough attention to environmental conflicts and to the advantages to of solving them through mediation procedure. The present paper deals with areas in which conflicts can be applied in environmental mediation and its benefits.


    Directory of Open Access Journals (Sweden)



    Full Text Available At a time of global economic crisis followed by resource crisis, a period in which the world seeks alternative resources through eco-investment, environmental conflicts are inevitable. Romania is among the few countries that do not pay enough attention to environmental conflicts and to the advantages to of solving them through mediation procedure. The present paper deals with areas in which conflicts can be applied in environmental mediation and its benefits.



    Nitheesh Krishnan M C*, B Suresh Kumar


    Different types of heat exchangers are extensively used in various industries to transfer the heat between cold and hot fluids. The key role of the heat exchanger is to transfer heat at maximum rate .Shell and Tube heat exchangers are having special importance in boilers, oil coolers, condensers, pre-heaters. Shell and Tube heat exchanger is one such heat exchanger, provides more area for heat transfer between two fluids in comparison with other type of heat exchanger. To intensify heat trans...

  15. The Multitalented MEDIATOR25

    Directory of Open Access Journals (Sweden)

    Kemal Kazan


    Full Text Available The multi-subunit Mediator complex, which links DNA-bound transcription factors to RNA Pol II during transcription, is an essential regulator of gene expression in all eukaryotes. Individual subunits of the Mediator complex integrate numerous endogenous and exogenous signals. In this paper, diverse regulatory functions performed by MEDIATOR25 (MED25, one of the subunits of the plant Mediator complex are reviewed. MED25 was first identified as a regulator of flowering time and named PHYTOCHROME AND FLOWERING TIME1 (PFT1. Since then, MED25 has been implicated in a range of other plant functions that vary from hormone signaling (JA, ABA, ethylene, and IAA to biotic and abiotic stress tolerance and plant development. MED25 physically interacts with transcriptional activators (e.g., AP2/ERFs, MYCs, and ARFs, repressors (e.g., JAZs and Aux/IAAs, and other Mediator subunits (MED13 and MED16. In addition, various genetic and epigenetic interactions involving MED25 have been reported. These features make MED25 one of the most multifunctional Mediator subunits and provide new insights into the transcriptional control of gene expression in plants.

  16. The Multitalented MEDIATOR25. (United States)

    Kazan, Kemal


    The multi-subunit Mediator complex, which links DNA-bound transcription factors to RNA Pol II during transcription, is an essential regulator of gene expression in all eukaryotes. Individual subunits of the Mediator complex integrate numerous endogenous and exogenous signals. In this paper, diverse regulatory functions performed by MEDIATOR25 (MED25), one of the subunits of the plant Mediator complex are reviewed. MED25 was first identified as a regulator of flowering time and named PHYTOCHROME AND FLOWERING TIME1 (PFT1). Since then, MED25 has been implicated in a range of other plant functions that vary from hormone signaling (JA, ABA, ethylene, and IAA) to biotic and abiotic stress tolerance and plant development. MED25 physically interacts with transcriptional activators (e.g., AP2/ERFs, MYCs, and ARFs), repressors (e.g., JAZs and Aux/IAAs), and other Mediator subunits (MED13 and MED16). In addition, various genetic and epigenetic interactions involving MED25 have been reported. These features make MED25 one of the most multifunctional Mediator subunits and provide new insights into the transcriptional control of gene expression in plants.

  17. Multilevel conceptualization of leader-member exchange processes: a comprehensive review

    National Research Council Canada - National Science Library

    Paik, Yonjeong


    .... Theoretical implications are discussed. Keywords: leader-member exchange, leadership style, leader-member exchange differentiation, coworker exchange relationship, relative leader-member exchange.

  18. 75 FR 48555 - Exchange Visitor Program-Trainees and Interns (United States)


    ... philosophy and principles set forth in that Executive Order. Training and Internship exchange programs... Interns. (a) Introduction. These regulations govern Exchange Visitor Programs under which foreign...

  19. Offshore Energy Knowledge Exchange Workshop Report

    Energy Technology Data Exchange (ETDEWEB)



    A report detailing the presentations and topics discussed at the Offshore Energy Knowledge Exchange Workshop, an event designed to bring together offshore energy industry representatives to share information, best practices, and lessons learned.

  20. Information Exchange, Market Transparency and Dynamic Oligopoly

    DEFF Research Database (Denmark)

    Møllgaard, H. Peter; Overgaard, Per Baltzer

    Economic literature often offers conflicting views on the likely efficiency effects of information exchanges, communication between firms, and market transparency. On the one hand, it is argued that increased information dissemination improves firm planning to the benefit of society (including...

  1. Iowa DOT project management peer exchange. (United States)


    This project supported the planning and conduct of a two-day Iowa Department of Transportationhosted peer exchange for state : agencies that have implemented some or all of the suggested strategies outlined in the Second Strategic Highway Research...

  2. Development of the stock exchange information system

    Directory of Open Access Journals (Sweden)

    Miladinović Radojko


    Full Text Available The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software project management methodology for their realization must be clearly defined. In the development process of the Belgrade Stock Exchange (BSE information system a new software project management methodology for its realization has been defined, the application of which is illustrated through a series of different development stages of the Belgrade Stock Exchange information system. In order to make all the problems more comprehensive, only the continuous trading method is described, being the most frequently used trading method in the world.

  3. Lightweight Thermal Storage Heat Exchangers Project (United States)

    National Aeronautics and Space Administration — This SBIR proposal aims to develop thermal energy storage heat exchangers that are significantly lighter and higher conductance than the present art which involves...

  4. Market efficiency in foreign exchange markets (United States)

    Oh, Gabjin; Kim, Seunghwan; Eom, Cheoljun


    We investigate the relative market efficiency in financial market data, using the approximate entropy(ApEn) method for a quantification of randomness in time series. We used the global foreign exchange market indices for 17 countries during two periods from 1984 to 1998 and from 1999 to 2004 in order to study the efficiency of various foreign exchange markets around the market crisis. We found that on average, the ApEn values for European and North American foreign exchange markets are larger than those for African and Asian ones except Japan. We also found that the ApEn for Asian markets increased significantly after the Asian currency crisis. Our results suggest that the markets with a larger liquidity such as European and North American foreign exchange markets have a higher market efficiency than those with a smaller liquidity such as the African and Asian markets except Japan.

  5. Assessment, Cleanup and Redevelopment Exchange System (ACRES) (United States)

    U.S. Environmental Protection Agency — The Assessment, Cleanup and Redevelopment Exchange System (ACRES) is an online database for Brownfields Grantees to electronically submit data directly to EPA.

  6. Securities and Exchange Commission Semiannual Regulatory Agenda (United States)


    ... payments to the purchaser are dependent on the performance of a securities index. On July 12, 2010, a... Agency Contact: Martha Mahan Haines, Division of Trading and Markets, Securities and Exchange Commission...

  7. NASA Earth Exchange Global Daily Downscaled Projections (United States)

    National Aeronautics and Space Administration — The NASA Earth Exchange Global Daily Downscaled Projections (NEX-GDDP) dataset is comprised of downscaled climate scenarios for the globe that are derived from the...

  8. Heat exchange fluids and techniques. [US patents

    Energy Technology Data Exchange (ETDEWEB)

    Ranney, M.W.


    The detailed, descriptive information presented is based on US patents, issued since January 1975, that deal with heat exchange fluids and techniques, and their potential for energy saving. This book serves a double purpose in that it supplies detailed technical information and can be used as a guide to the US patent literature in this field. By indicating all the information that is significant, and eliminating legal jargon and juristic phraseology, an advanced, technically oriented review of heat exchange fluids and techniques is presented. Information is included on the design and construction of heat exchangers; heat transfer fluids; low temperature processes; heat storage; heat transfer control in buildings; solar and geothermal energy processes; and industrial, medical, and residential uses of heat exchangers. (LCL)

  9. Data Exchanges and Verifications Online (DEVO) (United States)

    Social Security Administration — DEVO is the back-end application for processing SSN verifications and data exchanges. DEVO uses modern technology for parameter driven processing of both batch and...


    Directory of Open Access Journals (Sweden)

    L. E. Rovin


    Full Text Available At calculation of slot heat exchangers it is necessary to take into account the additional stream of heat transferred by emission from internal wall to an external one and further distributed between heated air and environment.

  11. Intelligent transportation system (ITS) international research exchange. (United States)


    ITS applications address surface transportation challenges in safety, mobility, and : sustainability that are similar in cause and impact worldwide. International ITS : exchange allows cooperating nations to benefit from each others pre-competitiv...

  12. Scaling in the Bombay stock exchange index

    Indian Academy of Sciences (India)

    Abstract. In this paper we study Bombay stock exchange (BSE) index financial time series for fractal and multifractal behaviour. We show that BSE index time series is monofractal and can be represented by a fractional Brownian motion.

  13. Integrating hospital information systems in healthcare institutions: a mediation architecture. (United States)

    El Azami, Ikram; Cherkaoui Malki, Mohammed Ouçamah; Tahon, Christian


    Many studies have examined the integration of information systems into healthcare institutions, leading to several standards in the healthcare domain (CORBAmed: Common Object Request Broker Architecture in Medicine; HL7: Health Level Seven International; DICOM: Digital Imaging and Communications in Medicine; and IHE: Integrating the Healthcare Enterprise). Due to the existence of a wide diversity of heterogeneous systems, three essential factors are necessary to fully integrate a system: data, functions and workflow. However, most of the previous studies have dealt with only one or two of these factors and this makes the system integration unsatisfactory. In this paper, we propose a flexible, scalable architecture for Hospital Information Systems (HIS). Our main purpose is to provide a practical solution to insure HIS interoperability so that healthcare institutions can communicate without being obliged to change their local information systems and without altering the tasks of the healthcare professionals. Our architecture is a mediation architecture with 3 levels: 1) a database level, 2) a middleware level and 3) a user interface level. The mediation is based on two central components: the Mediator and the Adapter. Using the XML format allows us to establish a structured, secured exchange of healthcare data. The notion of medical ontology is introduced to solve semantic conflicts and to unify the language used for the exchange. Our mediation architecture provides an effective, promising model that promotes the integration of hospital information systems that are autonomous, heterogeneous, semantically interoperable and platform-independent.

  14. Designing Alkaline Exchange Membranes from Scratch (United States)


    perfluorinated backbones invite interesting comparisons with the analogous proton exchange membranes. Conference Name: 220th ECS Meeting Conference...based on perfluorinated backbones invite interesting comparisons with the analogous proton exchange membranes. doi: 10.1149/1.3635708 2011, Volume 41...Liberatore,a and Andrew M. Herring,a a Department of Chemical Engineering and bDepartment of Chemistry and Geochemistry, Colorado School of Mines

  15. Modelling and simulation of a heat exchanger (United States)

    Xia, Lei; Deabreu-Garcia, J. Alex; Hartley, Tom T.


    Two models for two different control systems are developed for a parallel heat exchanger. First by spatially lumping a heat exchanger model, a good approximate model which has a high system order is produced. Model reduction techniques are applied to these to obtain low order models that are suitable for dynamic analysis and control design. The simulation method is discussed to ensure a valid simulation result.

  16. Heat-Exchanger/Heat-Pipe Interface (United States)

    Snyder, H. J.; Van Hagan, T. H.


    Monolithic assembly reliable and light in weight. Heat exchanger and evaporator ends of heat pipes integrated in monolithic halves welded together. Interface assembly connects heat exchanger of furnace, reactor, or other power source with heat pipes carrying heat to radiator or power-consuming system. One of several concepts proposed for nuclear power supplies aboard spacecraft, interface useful on Earth in solar thermal power systems, heat engines, and lightweight cooling systems.

  17. Map Specifications and Exchange of Geographical Information

    DEFF Research Database (Denmark)

    Frederiksen, Poul


    Specifications for Technical Maps 1993 – 99 are described giving an overview of the specification structure including the object description of the latest version: TK99.The technical map specifications are related to the standards for topographical maps - especially the TOP10DK standard. Common o...... object definitions are essential for the standards. Technical as well as topographical map information is exchangeable through the Danish developed “Standard for Exchange of Digital Map Information”, known as the DSFL-format....

  18. Real effective exchange rate misalignment in Nigeria


    Nwachukwu, Ngozi E.; Adebayo, Racheal O.; Shettima, Abdullahi M.; Anigwe, John O.; Udechukwu-Peterclaver, Chidinma T.


    The study analyzed the relationship between relevant macroeconomic variables and the real effective exchange rate (REER) in Nigeria based on the Behavioural Equilibrium Exchange Rate (BEER) approach. An Autoregressive Distributed Lag (ARDL) model was estimated to obtain the equilibrium REER while the resultant levels of misalignment were computed for the period 1990 - 2014. Model results indicated that terms of trade and degree of trade openness are significant determinants of the REER, imply...


    Directory of Open Access Journals (Sweden)

    George Halsey Beall


    Full Text Available In the past few years ion-exchange in glasses has found a renewed interest with a lot of new development and research in industrial and academic labs and the commercialization of materials with outstanding mechanical properties. These glasses are now widely used in many electronic devices including hand-held displays and tablets. The exchange is generally conducted in a bath of molten salt below the transition temperature of the glass. The exchange at the surface of an alkali ion by a bigger one brings compressive stress at the surface. The mechanical properties are dependent on the stress level at the surface and the depth of penetration of the bigger ion. As compared to glasses, glass-ceramics have the interest to display a wide range of aspects (transparent to opaque and different mechanical properties (especially higher modulus and toughness. There has been little research on ion-exchange in glass-ceramics. In these materials the mechanisms are much more complex than in glasses because of their polyphasic nature: ion-exchange generally takes place mostly in one phase (crystalline phase or residual glass. The mechanism can be similar to what is observed in glasses with the replacement of an ion by another in the structure. But in some cases this ion-exchange leads to microstructural modifications (for example amorphisation or phase change.This article reviews these ion-exchange mechanisms using several transparent and opaque alumino-silicate glass-ceramics as examples. The effect of the ion exchange in the various glass-ceramics will be described, with particular emphasis on flexural strength.

  20. Ion Exchange in Glass-Ceramics (United States)

    Beall, George; Comte, Monique; Deneka, Matthew; Marques, Paulo; Pradeau, Philippe; Smith, Charlene


    In the past few years ion-exchange in glasses has found a renewed interest with a lot of new development and research in industrial and academic labs and the commercialization of materials with outstanding mechanical properties. These glasses are now widely used in many electronic devices including hand-held displays and tablets. The exchange is generally conducted in a bath of molten salt below the transition temperature of the glass. The exchange at the surface of an alkali ion by a bigger one brings compressive stress at the surface. The mechanical properties are dependent on the stress level at the surface and the depth of penetration of the bigger ion. As compared to glasses, glass-ceramics have the interest to display a wide range of aspects (transparent to opaque) and different mechanical properties (especially higher modulus and toughness). There has been little research on ion-exchange in glass-ceramics. In these materials the mechanisms are much more complex than in glasses because of their polyphasic nature: ion-exchange generally takes place mostly in one phase (crystalline phase or residual glass). The mechanism can be similar to what is observed in glasses with the replacement of an ion by another in the structure. But in some cases this ion-exchange leads to microstructural modifications (for example amorphisation or phase change). This article reviews these ion-exchange mechanisms using several transparent and opaque alumino-silicate glass-ceramics as examples. The effect of the ion exchange in the various glass-ceramics will be described, with particular emphasis on flexural strength.

  1. Two Photon Exchange for Exclusive Pion Electroproduction

    Energy Technology Data Exchange (ETDEWEB)

    Afanaciev, Andrei V. [George Washington U.; Aleksejevs, Aleksandrs G. [Memorial University of Newfoundland, Newfoundland, Canada; Barkanova, Svetlana G. [Acadia University, Nova Scotia, Canada


    We perform detailed calculations of two-photon-exchange QED corrections to the cross section of pion electroproduction. The results are obtained with and without the soft-photon approximation; analytic expressions for the radiative corrections are derived. The relative importance of the two-photon correction is analyzed for the kinematics of several experiments at Jefferson Lab. A significant, over 20%, effect due to two-photon exchange is predicted for the backward angles of electron scattering at large transferred momenta.

  2. Stirling Engine With Radial Flow Heat Exchangers (United States)

    Vitale, N.; Yarr, George


    Conflict between thermodynamical and structural requirements resolved. In Stirling engine of new cylindrical configuration, regenerator and acceptor and rejector heat exchangers channel flow of working gas in radial direction. Isotherms in regenerator ideally concentric cylinders, and gradient of temperature across regenerator radial rather than axial. Acceptor and rejector heat exchangers located radially inward and outward of regenerator, respectively. Enables substantial increase in power of engine without corresponding increase in diameter of pressure vessel.

  3. When Ligand Exchange Leads to Ion Exchange: Nanocrystal Facets Dictate the Outcome. (United States)

    Hewavitharana, Indika K; Brock, Stephanie L


    This study demonstrates that ligand exchange of nanocrystals (NCs) is not always an innocuous process, but can lead to facile (room temperature) ion exchange, depending on the surface crystal faceting. Rock salt PbTe NCs prepared as cubes with neutral facets undergo room-temperature ligand exchange with sulfide ions, whereas cuboctahedron-shaped particles with neutral {100} and polar {111} facets are transformed to PbS, driven by ion exchange along the ⟨111⟩ direction. Likewise, cation exchange (with Ag + ) occurs rapidly for cuboctahedra, whereas cubes remain inert. This dramatic difference is attributed to the relative surface area of {111} facets that promote rapid ion exchange and shows how facet engineering is a powerful knob for the control of reaction pathways in nanoparticles.

  4. Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle. (United States)

    Grabon, Aby; Orłowski, Adam; Tripathi, Ashutosh; Vuorio, Joni; Javanainen, Matti; Róg, Tomasz; Lönnfors, Max; McDermott, Mark I; Siebert, Garland; Somerharju, Pentti; Vattulainen, Ilpo; Bankaitis, Vytas A


    Phosphatidylinositol-transfer proteins (PITPs) regulate phosphoinositide signaling in eukaryotic cells. The defining feature of PITPs is their ability to exchange phosphatidylinositol (PtdIns) molecules between membranes, and this property is central to PITP-mediated regulation of lipid signaling. However, the details of the PITP-mediated lipid exchange cycle remain entirely obscure. Here, all-atom molecular dynamics simulations of the mammalian StART-like PtdIns/phosphatidylcholine (PtdCho) transfer protein PITPα, both on membrane bilayers and in solvated systems, informed downstream biochemical analyses that tested key aspects of the hypotheses generated by the molecular dynamics simulations. These studies provided five key insights into the PITPα lipid exchange cycle: (i) interaction of PITPα with the membrane is spontaneous and mediated by four specific protein substructures; (ii) the ability of PITPα to initiate closure around the PtdCho ligand is accompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix; (iii) the energy barrier of phospholipid extraction from the membrane is lowered by a network of hydrogen bonds between the lipid molecule and PITPα; (iv) the trajectory of PtdIns or PtdCho into and through the lipid-binding pocket is chaperoned by sets of PITPα residues conserved throughout the StART-like PITP family; and (v) conformational transitions in the C-terminal helix have specific functional involvements in PtdIns transfer activity. Taken together, these findings provide the first mechanistic description of key aspects of the PITPα PtdIns/PtdCho exchange cycle and offer a rationale for the high conservation of particular sets of residues across evolutionarily distant members of the metazoan StART-like PITP family. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  5. Seed exchange networks, ethnicity, and sorghum diversity. (United States)

    Labeyrie, Vanesse; Thomas, Mathieu; Muthamia, Zachary K; Leclerc, Christian


    Recent studies investigating the relationship between crop genetic diversity and human cultural diversity patterns showed that seed exchanges are embedded in farmers' social organization. However, our understanding of the social processes involved remains limited. We investigated how farmers' membership in three major social groups interacts in shaping sorghum seed exchange networks in a cultural contact zone on Mount Kenya. Farmers are members of residence groups at the local scale and of dialect groups clustered within larger ethnolinguistic units at a wider scale. The Chuka and Tharaka, who are allied in the same ethnolinguistic unit, coexist with the Mbeere dialect group in the study area. We assessed farmers' homophily, propensity to exchange seeds with members of the same group, using exponential random graph models. We showed that homophily is significant within both residence and ethnolinguistic groups. At these two levels, homophily is driven by the kinship system, particularly by the combination of patrilocal residence and ethnolinguistic endogamy, because most seeds are exchanged among relatives. Indeed, residential homophily in seed exchanges results from local interactions between women and their in-law family, whereas at a higher level, ethnolinguistic homophily is driven by marriage endogamy. Seed exchanges and marriage ties are interrelated, and both are limited between the Mbeere and the other groups, although frequent between the Chuka and Tharaka. The impact of these social homophily processes on crop diversity is discussed.

  6. Real-time Control Mediation in Agile Distributed Software Development

    DEFF Research Database (Denmark)

    Persson, John Stouby; Aaen, Ivan; Mathiassen, Lars


    Agile distributed environments pose particular challenges related to control of quality and collaboration in software development. Moreover, while face-to-face interaction is fundamental in agile development, distributed environments must rely extensively on mediated interactions. On this backdrop......-time mediated control exchanges; and, that the actors, despite distances in space and culture, developed a clan-like pattern mediated by technology to help control quality and collaboration in software development......., we report from an in-depth case study of an agile distributed software project. Applying Kirsch’s elements of control framework, we analyze how actors in this context used different elements of control. We offer a description of the general management context and provide a detailed analysis of how...

  7. Coworker exchange: relationships between coworkers, leader-member exchange, and work attitudes. (United States)

    Sherony, Kathryn M; Green, Stephen G


    The study of leadership exchanges is extended by studying both leader-member exchanges (LMXs) and coworker exchanges (CWXs). Data from 110 coworker dyads were used to examine relationships between LMXs and CWXs and between exchange relationships and work attitudes. As predicted, the interaction between 2 coworkers' LMX scores predicted CWX quality for the coworker dyad. Also, after controlling for LMX, greater diversity in a worker's CWX relationships was negatively related to his or her organizational commitment but not job satisfaction. The quality of a worker's CWX relationships, however, did not moderate the relationship between CWX diversity and work attitudes.

  8. Magnetic stability in exchange-spring and exchange bias systems after multiple switching cycles.

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, J. S.; Inomata, A.; You, C.-Y.; Pearson, J. E.; Bader, S. D.


    We have studied the magnetic stability in exchange bias and exchange spring systems prepared via epitaxial sputter deposition. The two interfacial exchange coupled systems, Fe/Cr(211) double superlattices consisting of a ferromagnetic and an antiferromagnetic Fe/Cr superlattice that are exchange coupled through a Cr spacer, and Sin-Co/Fe exchange-spring bilayer structures with ferromagnetically coupled hard Sin-Co layer and soft Fe layer, were epitaxially grown on suitably prepared Cr buffer layers to give rise to different microstructure and magnetic anisotropy. The magnetic stability was investigated using the magneto-optic Kerr effect during repeated reversal of the soft layer magnetization by field cycling up to 10{sup 7} times. For uniaxial Fe/Cr exchange biased double superlattices and exchange spring bilayers with uniaxial Sin-Co, small but rapid initial decay in the exchange bias field HE and in the remanent magnetization is observed. However, the exchange spring bilayers with biaxial and random in-plane anisotropy in the Sin-Co layer shows gradual decay in H{sub E} and without large reduction of the magnetization. The different decay behaviors are attributed to the different microstructure and spin configuration of the pinning layers.

  9. Justice at the millennium, a decade later: a meta-analytic test of social exchange and affect-based perspectives. (United States)

    Colquitt, Jason A; Scott, Brent A; Rodell, Jessica B; Long, David M; Zapata, Cindy P; Conlon, Donald E; Wesson, Michael J


    Although a flurry of meta-analyses summarized the justice literature at the turn of the millennium, interest in the topic has surged in the decade since. In particular, the past decade has witnessed the rise of social exchange theory as the dominant lens for examining reactions to justice, and the emergence of affect as a complementary lens for understanding such reactions. The purpose of this meta-analytic review was to test direct, mediating, and moderating hypotheses that were inspired by those 2 perspectives, to gauge their adequacy as theoretical guides for justice research. Drawing on a review of 493 independent samples, our findings revealed a number of insights that were not included in prior meta-analyses. With respect to social exchange theory, our results revealed that the significant relationships between justice and both task performance and citizenship behavior were mediated by indicators of social exchange quality (trust, organizational commitment, perceived organizational support, and leader-member exchange), though such mediation was not apparent for counterproductive behavior. The strength of those relationships did not vary according to whether the focus of the justice matched the target of the performance behavior, contrary to popular assumptions in the literature, or according to whether justice was referenced to a specific event or a more general entity. With respect to affect, our results showed that justice-performance relationships were mediated by positive and negative affect, with the relevant affect dimension varying across justice and performance variables. Our discussion of these findings focuses on the merit in integrating the social exchange and affect lenses in future research.

  10. Mediation: The Wise Advocacy

    Directory of Open Access Journals (Sweden)

    Towseef Ahmad


    Full Text Available AbstractAdversarial litigation is not the only means of resolving disputes and settling of claims. There are various options. Alternative means of dispute resolution can save money and time, and can help to anchor and resolve the dispute while exploring valuable good offices, amicable approaches and facilitation. Mediation, as used in law, is a process of managing negotiation by a neutral third party in the form of Alternative Dispute Resolution (ADR, as a convenient way of resolving disputes between two or more parties with speediation processes. On the sidelines typically, a neutral third party, the mediator assists the parties to negotiate a settlement. The term “mediation” broadly refers to any instance in which a neutral third party helps others to reach an amicable and mutually acceptable agreement. More specifically, mediation has a structure, timetable and dynamic approaches that “ordinary” negotiations usually lack. The process helps the parties to flourish the healthy ideas which are different and distinct from the legal rights in a Court of law. It is well known in International Law also and disputants can submit their disputes to mediation in a variety of matters such as commercial, legal, diplomatic, workplace, community and family matters, which assumes a great significance and it is bricolaged within the framework of this article.Keywords: Adversarial, Litigation, Mediation, Negotiation and Amicable.

  11. Immunologically mediated oral diseases

    Directory of Open Access Journals (Sweden)

    Sudha Jimson


    Full Text Available Immune mediated diseases of oral cavity are uncommon. The lesions may be self-limiting and undergo remission spontaneously. Among the immune mediated oral lesions the most important are lichen planus, pemphigus, erythema multiformi, epidermolysis bullosa, systemic lupus erythematosis. Cellular and humoral mediated immunity play a major role directed against epithelial and connective tissue in chronic and recurrent patterns. Confirmatory diagnosis can be made by biopsy, direct and indirect immunoflouresence, immune precipitation and immunoblotting. Therapeutic agents should be selected after thorough evaluation of immune status through a variety of tests and after determining any aggravating or provoking factors. Early and appropriate diagnosis is important for proper treatment planning contributing to better prognosis and better quality of life of patient.

  12. Extratropical Stratosphere-Troposphere Mass Exchange (United States)

    Schoeberl, Mark R.


    Understanding the exchange of gases between the stratosphere and the troposphere is important for determining how pollutants enter the stratosphere and how they leave. This study does a global analysis of that the exchange of mass between the stratosphere and the troposphere. While the exchange of mass is not the same as the exchange of constituents, you can t get the constituent exchange right if you have the mass exchange wrong. Thus this kind of calculation is an important test for models which also compute trace gas transport. In this study I computed the mass exchange for two assimilated data sets and a GCM. The models all agree that amount of mass descending from the stratosphere to the troposphere in the Northern Hemisphere extra tropics is approx. 10(exp 10) kg/s averaged over a year. The value for the Southern Hemisphere by about a factor of two. ( 10(exp 10) kg of air is the amount of air in 100 km x 100 km area with a depth of 100 m - roughly the size of the D.C. metro area to a depth of 300 feet.) Most people have the idea that most of the mass enters the stratosphere through the tropics. But this study shows that almost 5 times more mass enters the stratosphere through the extra-tropics. This mass, however, is quickly recycled out again. Thus the lower most stratosphere is a mixture of upper stratospheric air and tropospheric air. This is an important result for understanding the chemistry of the lower stratosphere.

  13. Ion Exchange Resins Transforming Drug Delivery Systems. (United States)

    Gupta, Shweta; Benien, Parul; Sahoo, P K


    Ion-exchange resins are light, porous, three-dimensional high molecular weight cross - linked matrix of hydrocarbon chains carrying positively or negatively charged sites that can attract an ion of opposite charge from the surrounding medium. There is stoichiometric exchange of mobile ions between the solid and the solution called as Ion-exchange which does not lead to any radical change in the properties and structure of the solid. Depending upon the type of Ionexchanged it can be either Cation-exchange or Anion-exchange. They are prepared in the form of granules, beads or sheets. As drug delivery systems they have received considerable attention after the 1950s due to their inertness, freedom from side effects, high drug loading capacity, ease of sterilization and the fact that their structure can be easily altered to achieve the desired drug release characteristics. Their use is revolutionizing all traditional delivery systems namely - oral, nasal, ophthalmic and parenteral. Ion- exchange resins have been used for the development of novel drug delivery systems (NDDSs), to modify the characteristics of the dosage form and various other biomedical applications. The present article deals with the varied applications of ion-exchange resins for taste making, as resinates (simple and microencapsulated or coated), Pennkinetic systems, in selective recovery of pharmaceuticals, in pH and ionic strength responsive systems, in gastro-retentive systems, in hollow fiber systems, as sigmoidal release systems, as site specific delivery systems and as inotophoretically assisted transdermal drug delivery systems. They also have an immense importance when used as disintegrants / superdisintegrants in formulation of orodispersible tablets, powder processing aids and in the dissolution and stabilization of drugs.

  14. Can positive social exchanges buffer the detrimental effects of negative social exchanges? Age and gender differences. (United States)

    Fiori, Katherine L; Windsor, Tim D; Pearson, Elissa L; Crisp, Dimity A


    Findings from existing research exploring whether positive social exchanges can help to offset (or 'buffer' against) the harmful effects of negative social exchanges on mental health have been inconsistent. This could be because the existing research is characterized by different approaches to studying various contexts of 'cross-domain' and 'within-domain' buffering, and/or because the nature of buffering effects varies according to sociodemographic characteristics that underlie different aspects of social network structure and function. The purpose of this study was to examine whether the buffering effects of global perceptions of positive exchanges on the link between global negative exchanges and mental health varied as a function of age and gender. We used a series of regressions in a sample of 556 Australian older adults (ages 55-94) to test for three-way interactions among gender, positive social exchanges, and negative social exchanges, as well as age and positive and negative social exchanges, in predicting mental health, controlling for years of education, partner status, and physical functioning. We found that positive exchanges buffered against negative exchanges for younger old adults, but not for older old adults, and for women, but not for men. Our findings are interpreted in light of research on individual differences in coping responses and interpersonal goals among late middle-aged and older adults. Our findings are in line with gerontological theories (e.g., socioemotional selectivity theory), and imply that an intervention aimed at using positive social exchanges as a means of coping with negative social exchanges might be more successful among particular populations (i.e., women, 'younger' old adults). Copyright © 2012 S. Karger AG, Basel.

  15. "Small Talk Is Not Cheap": Phatic Computer-Mediated Communication in Intercultural Classes (United States)

    Maíz-Arévalo, Carmen


    The present study aims to analyse the phatic exchanges performed by a class of nine intercultural Master's students during a collaborative assignment which demanded online discussion using English as a lingua franca (ELF). Prior studies on the use of phatic communication in computer-mediated communication have concentrated on social networking…

  16. Models as Mediators

    DEFF Research Database (Denmark)

    Sommerlund, Julie

    from laboratory studies, (Latour 1979; Lynch 1985; Sommerlund 2004 (2007); Sommerlund 2006) and is complemented by the attention paid to the "mediator" by Hennion (1989; 1997; 2005). The empirical focus will be on a central - but overlooked - actor of branding and advertising; the model. The model has...... solely been theorized within cultural studies (Craik 1994) as feminine spectacle, but has been neglected as mediator and actor. This paper will argue that models are co-producers of brands, and vice versa. Empirically, the paper will present interviews with models, model-scouts, agents, and advertisers...

  17. 14 CFR 29.1125 - Exhaust heat exchangers. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Exhaust heat exchangers. 29.1125 Section 29... exchangers. For reciprocating engine powered rotorcraft the following apply: (a) Each exhaust heat exchanger... is subject to contact with exhaust gases; and (4) No exhaust heat exchanger or muff may have stagnant...

  18. 14 CFR 25.1125 - Exhaust heat exchangers. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Exhaust heat exchangers. 25.1125 Section 25... exchangers. For reciprocating engine powered airplanes, the following apply: (a) Each exhaust heat exchanger... provisions wherever it is subject to contact with exhaust gases; and (4) No exhaust heat exchanger or muff...

  19. 40 CFR 63.104 - Heat exchange system requirements. (United States)


    ... heat exchange system or at locations where the cooling water enters and exits each heat exchanger or any combination of heat exchangers. (i) For samples taken at the entrance and exit of recirculating... manufacturing process units. (iii) For samples taken at the entrance and exit of each heat exchanger or any...

  20. 21 CFR 870.4240 - Cardiopulmonary bypass heat exchanger. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary bypass heat exchanger. 870.4240... bypass heat exchanger. (a) Identification. A cardiopulmonary bypass heat exchanger is a device, consisting of a heat exchange system used in extracorporeal circulation to warm or cool the blood or...

  1. [Comparison of the effects of exchange forms on social solidarity]. (United States)

    Inaba, Misato; Takahashi, Nobuyuki


    Although social solidarity is an essential component that helps maintaining social order, what produces solidarity and how does it work have not been fully investigated. We conducted an experiment to examine whether experiencing different forms of social exchange produces different levels of solidarity. We compared four forms of social exchange: reciprocal exchange (exchange resources without negotiation), negotiated exchange (with negotiation), pure-generalized exchange (giver can choose who to give) and chain-generalized exchange (giver cannot choose who to give). Two dimensions classify these exchanges: the number of players (two vs. more than two), and involvement of negotiation. Reciprocal and negotiated exchanges occur within dyads, while pure- and chain-generalized exchanges involve three or more players. Only the negotiated exchange involves negotiation process; the other exchanges are purely unilateral giving. Participants played a one-shot social dilemma game (SDG) before and after social exchange session. The more the players cooperated in SDG, the stronger the social solidarity. Results show that the cooperation rate in SDG increased more in the reciprocal, pure- and chain-generalized exchange conditions than that in the negotiated exchange condition, suggesting that social solidarity is facilitated by experiencing social exchange which does not involve negotiation.

  2. Social Network Analysis of the Farabi Exchange Program: Student Mobility (United States)

    Ugurlu, Zeynep


    Problem Statement: Exchange programs offer communication channels created through student and instructor exchanges; a flow of information takes place through these channels. The Farabi Exchange Program (FEP) is a student and instructor exchange program between institutions of higher education. Through the use of social network analysis and…

  3. real exchange rate misalignment and economic performance in ...

    African Journals Online (AJOL)

    KEYWORDS:Exchange rate misalignment,co-integration and economic growth. INTRODUCTION. Real exchange rate misalignment and economic performance has continued to gain currency in recent policy debates. This is because exchange rate misalignment may result in undesirable economic performance. Exchange.

  4. Real exchange rate misalignment and economic performance in ...

    African Journals Online (AJOL)

    This article investigates the behavior of equilibrium exchange rate and real exchange rate misalignment in Sudan over the period 1979– 2009. In addition, the impact of real exchange rate misalignment on economic performance is examined. The empirical results show that the equilibrium exchange rate is significantly ...

  5. Two on exchange : Transferring Goods or Splitting a Resource Pool

    NARCIS (Netherlands)

    Dijkstra, Jacob; Van Assen, Marcel A. L. M.

    We investigated the consequences for exchange outcomes of the violation of an assumption underlying most social psychological research on exchange. This assumption is that the negotiated direct exchange of commodities between two actors (pure exchange) can be validly represented as two actors

  6. Circuit QED with qutrits: Coupling three or more atoms via virtual-photon exchange (United States)

    Zhao, Peng; Tan, Xinsheng; Yu, Haifeng; Zhu, Shi-Liang; Yu, Yang


    We present a model to describe a generic circuit QED system which consists of multiple artificial three-level atoms, namely, qutrits, strongly coupled to a cavity mode. When the state transition of the atoms disobeys the selection rules the process that does not conserve the number of excitations can happen determinatively. Therefore, we can realize coherent exchange interaction among three or more atoms mediated by the exchange of virtual photons. In addition, we generalize the one-cavity-mode mediated interactions to the multicavity situation, providing a method to entangle atoms located in different cavities. Using experimentally feasible parameters, we investigate the dynamics of the model including three cyclic-transition three-level atoms, for which the two lowest energy levels can be treated as qubits. Hence, we have found that two qubits can jointly exchange excitation with one qubit in a coherent and reversible way. In the whole process, the population in the third level of atoms is negligible and the cavity photon number is far smaller than 1. Our model provides a feasible scheme to couple multiple distant atoms together, which may find applications in quantum information processing.



    V.NATARAJAN,; Dr. P. Senthil Kumar


    This paper focused on the investigational cram of the recital characteristics of tube-in-tube compact heat exchangers. Experiments are conducted in the compact heat exchangers with R-134a and liquefiedpetroleum gas. The effectiveness of the heat exchangers was calculated using the experiment data and it was found that the effectiveness of heat exchanger-1 is above 75 and heat exchanger-2 is above 84% for R-134a.The effectiveness of heat exchanger-1 is about 60% and heat exchanger-2 is about 8...

  8. Phase Change Material Heat Exchanger Life Test (United States)

    Lillibridge, Sean; Stephan, Ryan


    Low Lunar Orbit (LLO) poses unique thermal challenges for the orbiting space craft, particularly regarding the performance of the radiators. The IR environment of the space craft varies drastically from the light side to the dark side of the moon. The result is a situation where a radiator sized for the maximal heat load in the most adverse situation is subject to freezing on the dark side of the orbit. One solution to this problem is to implement Phase Change Material (PCM) Heat Exchangers. PCM Heat Exchangers act as a "thermal capacitor," storing thermal energy when there is too much being produced by the space craft to reject to space, and then feeding that energy back into the thermal loop when conditions are more favorable. Because they do not use an expendable resource, such as the feed water used by sublimators and evaporators, PCM Heat Exchangers are ideal for long duration LLO missions. In order to validate the performance of PCM Heat Exchangers, a life test is being conducted on four n-Pentadecane, carbon filament heat exchangers. Fluid loop performance, repeatability, and measurement of performance degradation over 2500 melt-freeze cycles will be performed.

  9. Plate-fin exchangers offshore - the details

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, M.


    Details are given of how plate-fin heat exchangers (PFHEs) have been evaluated for use in three North Sea oil fields: BP's Marnock, Shell's Gannet and Statoil's Sleipner. Comparison is made with conventional shell and tube (S and T) exchangers. The general conclusions reached from these and other studies are that overall it seems worthwhile to install aluminium PFHEs where possible offshore. Titanium PFHEs do not appear to compete with carbon steel shell and tube heat exchangers. PFHEs are smaller, lighter and usually cheaper than their S and T equivalents, and this is reinforced by significant knock-on savings in pipework and utilities. To take full advantage of the knock-on effect, however, it is essential to plan the use of PFHEs while the design is still flexible enough to make best use of them. PFHEs can also achieve tighter temperature approaches than S and T exchangers, and this can give further savings. Extending the potential of PFHEs to give full process integration has not shown enough benefits in offshore applications to overcome the drawbacks of complexity and lack of operability and flexibility. Utility circulation rates can be much reduced using counter-current PFHEs in place of S and T exchangers. Coolant and heating fluid circulation rates are limited only by minimum temperature approach and economic trade-off with the cost of the PFHE hardware, provided the circulating fluid is a properly formulated heat transfer fluid. (author).

  10. Enhanced skyrmion stability due to exchange frustration. (United States)

    von Malottki, S; Dupé, B; Bessarab, P F; Delin, A; Heinze, S


    Skyrmions are localized, topologically non-trivial spin structures which have raised high hopes for future spintronic applications. A key issue is skyrmion stability with respect to annihilation into the ferromagnetic state. Energy barriers for this collapse have been calculated taking only nearest neighbor exchange interactions into account. Here, we demonstrate that exchange frustration can greatly enhance skyrmion stability. We focus on the prototypical film system Pd/Fe/Ir(111) and use an atomistic spin model parametrized from first-principles calculations. We show that energy barriers and critical fields of skyrmion collapse as well as skyrmion lifetimes are drastically enhanced due to frustrated exchange and that antiskyrmions are metastable. In contrast an effective nearest-neighbor exchange model can only account for equilibrium properties of skyrmions such as their magnetic field dependent profile or the zero temperature phase diagram. Our work shows that frustration of long range exchange interactions - a typical feature in itinerant electron magnets - is a route towards enhanced skyrmion stability even in systems with a ferromagnetic ground state.

  11. Symmetry in social exchange and health (United States)

    Siegrist, Johannes


    Symmetry is a relevant concept in sociological theories of exchange. It is rooted in the evolutionary old norm of social reciprocity and is particularly important in social contracts. Symmetry breaking through violation of the norm of reciprocity generates strain in micro-social systems and, above all, in victims of non-symmetric exchange. In this contribution, adverse healthconsequences of symmetry breaking in contractual social exchange are analysed, with a main focus on the employment contract. Scientific evidence is derived from prospective epidemiological studies testing the model of effort-reward imbalance at work. Overall, a twofold elevated risk of incident disease is observed in employed men and women who are exposed to non-symmetric exchange. Health risks include coronary heart disease, depression and alcohol dependence, among others. Preliminary results suggest similar effects on health produced by symmetry breaking in other types of social relationships (e.g. partnership, parental roles). These findings underline the importance of symmetry in contractual social exchange for health and well-being.

  12. Solvent Extraction and Ion Exchange in Radiochemistry (United States)

    Skarnemark, G.

    In 1805, Bucholz extracted uranium from a nitric acid solution into ether and back-extracted it into pure water. This is probably the first reported solvent-extraction investigation. During the following decades, the distribution of neutral compounds between aqueous phases and pure solvents was studied, e.g., by Peligot, Berthelot and Jungfleisch, and Nernst. Selective extractants for analytical purposes became available during the first decades of the twentieth century. From about 1940, extractants such as organophosphorous esters and amines were developed for use in the nuclear fuel cycle. This connection between radiochemistry and solvent-extraction chemistry made radiochemists heavily involved in the development of new solvent extraction processes, and eventually solvent extraction became a major separation technique in radiochemistry. About 160 years ago, Thompson and Way observed that soil can remove potassium and ammonium ions from an aqueous solution and release calcium ions. This is probably the first scientific report on an ion-exchange separation. The first synthesis of the type of organic ion exchangers that are used today was performed by Adams and Holmes in 1935. Since then, ion-exchange techniques have been used extensively for separations of various radionuclides in trace as well as macro amounts. During the last 4 decades, inorganic ion exchangers have also found a variety of applications. Today, solvent extraction as well as ion exchange are used extensively in the nuclear industry and for nuclear, chemical, and medical research. Some of these applications are discussed in the chapter.

  13. Proton channels and exchangers in cancer. (United States)

    Spugnini, Enrico Pierluigi; Sonveaux, Pierre; Stock, Christian; Perez-Sayans, Mario; De Milito, Angelo; Avnet, Sofia; Garcìa, Abel Garcìa; Harguindey, Salvador; Fais, Stefano


    Although cancer is characterized by an intratumoral genetic heterogeneity, a totally deranged pH control is a common feature of most cancer histotypes. Major determinants of aberrant pH gradient in cancer are proton exchangers and transporters, including V-ATPase, Na+/H+ exchanger (NHE), monocarboxylate transporters (MCTs) and carbonic anhydrases (CAs). Thanks to the activity of these proton transporters and exchangers, cancer becomes isolated and/or protected not only from the body reaction against the growing tumor, but also from the vast majority of drugs that when protonated into the acidic tumor microenvironment do not enter into cancer cells. Proton transporters and exchangers represent a key feature tumor cells use to survive in the very hostile microenvironmental conditions that they create and maintain. Detoxifying mechanisms may thus represent both a key survival option and a selection outcome for cells that behave as unicellular microorganisms rather than belonging to an organ, compartment or body. It is, in fact, typical of malignant tumors that, after a clinically measurable yet transient initial response to a therapy, resistant tumor clones emerge and proliferate, thus bursting a more malignant behavior and rapid tumor progression. This review critically presents the background of a novel and efficient approach that aims to fight cancer through blocking or inhibiting well characterized proton exchangers and transporters active in human cancer cells. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. The non-Boussinesq lock exchange problem (United States)

    Linden, Paul; Lowe, Ryan; Rottman, James


    The results of an experimental study of the non-Boussinesq lock exchange problem are described. The experiments were performed in a rectangular channel using water and a Sodium Iodide solution as the two fluids, which gave a maximum density difference of about 60experiments is to resolve some recent controversy about how gravity currents evolve from a flow at rest to the well-known steady-state gravity current made famous by Benjamin (1968). It has been argued, based on two-dimensional shallow-water theory, that Benjamin’s steady-state energy-conserving gravity current cannot evolve from the lock-exchange (or any physically reasonable) initial conditions. The experiments show that this is not true. A theory for the non-Boussinesq problem is derived that is valid for the lock-exchange problem for large times after the flow is initiated. This theory requires the formulation of a two-layer theory for hydraulic jumps in non-Boussinesq fluids. The results of the model are compared with our lock-exchange experiments and with two previous non-Boussinesq sets of lock exchange experiments, both of which use a combination of exotic gases or gases and liquids as the working fluids, with good qualitative agreement.

  15. Chain exchange in triblock copolymer micelles (United States)

    Lu, Jie; Lodge, Timothy; Bates, Frank


    Block polymer micelles offer a host of technological applications including drug delivery, viscosity modification, toughening of plastics, and colloidal stabilization. Molecular exchange between micelles directly influences the stability, structure and access to an equilibrium state in such systems and this property recently has been shown to be extraordinarily sensitive to the core block molecular weight in diblock copolymers. The dependence of micelle chain exchange dynamics on molecular architecture has not been reported. The present work conclusively addresses this issue using time-resolved small-angle neutron scattering (TR-SANS) applied to complimentary S-EP-S and EP-S-EP triblock copolymers dissolved in squalane, a selective solvent for the EP blocks, where S and EP refer to poly(styrene) and poly(ethylenepropylene), respectively. Following the overall SANS intensity as a function of time from judiciously deuterium labelled polymer and solvent mixtures directly probes the rate of molecular exchange. Remarkably, the two triblocks display exchange rates that differ by approximately ten orders of magnitude, even though the solvophobic S blocks are of comparable size. This discovery is considered in the context of a model that successfully explains S-EP diblock exchange dynamics.

  16. 77 FR 69694 - Determination of Foreign Exchange Swaps and Foreign Exchange Forwards Under the Commodity... (United States)


    ... foreign exchange options, currency swaps, or non-deliverable forwards (``NDFs''). Among other measures... currency from that counterparty. The payment obligations on currency swaps, interest rate swaps, credit... derivatives. Foreign exchange options, currency swaps, and NDFs (as discussed below) may not be exempted from...

  17. 78 FR 46622 - Application of Topaz Exchange, LLC for Registration as a National Securities Exchange; Findings... (United States)


    ..., Opinion, and Order of the Commission July 26, 2013. I. Introduction On July 3, 2012, Topaz Exchange, LLC... Exchange is structured as a Delaware limited liability company ] (``LLC''), and is a wholly-owned... directors, including three Non-Industry Directors),\\45\\ a Finance and Audit Committee (consisting of between...

  18. Exchange-rate forecasts and asymmetric loss: empirical evidence for the yen/dollar exchange rate

    DEFF Research Database (Denmark)

    Stadtmann, Georg; Pierdzioch; Rülke


    We used the yen/dollar exchange-rate forecasts of the Wall Street Journal (WSJ) poll to analyse whether exchange-rate forecasters have an asymmetric loss function. To this end, we applied an approach recently developed by Elliott et al. (2005). We found that only few forecasters seem to form...

  19. Where Would the EUR/CHF Exchange Rate be Without the SNB's Minimum Exchange Rate Policy?

    DEFF Research Database (Denmark)

    Hanke, Michael; Poulsen, Rolf; Weissensteiner, Alex


    Since its announcement made on September 6, 2011, the Swiss National Bank (SNB) has been pursuing the goal of a minimum EUR/CHF exchange rate of 1.20, promising to intervene on currency markets to prevent the exchange rate from falling below this level.We use a compound option pricing approach...

  20. 75 FR 3281 - Regulation of Off-Exchange Retail Foreign Exchange Transactions and Intermediaries (United States)


    ... bill which would have maintained the status quo for institutional off-exchange forex trading, leaving jurisdiction over on-exchange trading in futures and options contracts on forex with the newly-created... only excluded spot or forward forex transactions from the Commission's jurisdiction, and that trading...

  1. 75 FR 55409 - Regulation of Off-Exchange Retail Foreign Exchange Transactions and Intermediaries (United States)


    ... forex trading. Unlike segregation of customer funds deposited for futures trading, under the relevant provisions of the Bankruptcy Code,\\31\\ such amounts held in connection with retail forex trading would not... Trading Commission 17 CFR Parts 1, 3, 4, et al. Regulation of Off-Exchange Retail Foreign Exchange...

  2. Cultural mediation in museums

    Directory of Open Access Journals (Sweden)

    Gherghina Boda


    Full Text Available If we perceive the museum not only as a place of storing and conserving the patrimony, but also of transmitting it, then we can also see it as a mediator through which cultures can become collective patrimony. Tightly connected to patrimonial appropriation, mediation appears from this perspective as a process and not an end, as it manifests itself in animation, communication and making knowledge popular in relation to a precise patrimony. That is why we can see cultural mediation as a transmission, as a transformation, as an action or social project which aims at creating social bonds, the museum thus being not only a place of meeting for the public with the objects exposed, but also as a place of meeting between different cultures. Thus, cultural mediation presents itself as the most efficient means for access to culture of all categories of the public, situated as the crossroads of culture, continuous education and entertainment and is inscribed in the field of informal education.

  3. Teachers as mediators

    DEFF Research Database (Denmark)

    Dorf, Hans; Kelly, Peter; Hohmann, Ulrike


    Within the context of lower secondary English teaching in South West England, this study identifies in broad terms the competing goals between which English teachers mediate and the explicit and hidden tensions that result. To understand the interactions of competing goals, teachers’ goal...

  4. Mediation and Automatization. (United States)

    Hutchins, Edwin

    This paper discusses the relationship between the mediation of task performance by some structure that is not inherent in the task domain itself and the phenomenon of automatization, in which skilled performance becomes effortless or phenomenologically "automatic" after extensive practice. The use of a common simple explicit mediating…

  5. Mediation in Violent Conflict


    Baumann, Jonas; Clayton, Govinda


    Mediation is a process in which a third party assists the disputants, with their consent, in preventing, managing, or resolving a conflict. It is a widely used conflict resolution tool. Nevertheless, to improve its effectiveness, concepts need to be clarified, its strengths and limits recognized, and the field professionalized.

  6. The Bensberg Mediation Model

    Directory of Open Access Journals (Sweden)

    Raluca - Marilena Mihalcioiu


    Full Text Available The basis of the conflict through the mediation represents the objectives and procedures ofmediation, mediation of a conflict. The conflict will not be disclosed to others, but the parties will be creditedthe authority to resolve the conflict, the conflict among themselves with the help of a mediator. The disputeshould be resolved by the parties with help of a third party. The parties in conflict (it may be several personsare jointly responsible for the solution. They seek together a way that leads to long-term settlement of theconflict. The assumption of responsibility in this process strengthens the confidence and the importance oftheir decision. Important is that losers usually have no peace, because they are out for revenge. Winners don’tneed peace. If both parties lose, remains disappointing, with the understanding of which the conflict isresolved, will understand each other better developed. Reconciliation is therefore a longer-term goal.Conflicts also help to clarify roles. The paper presents Bensberg Model of Mediation, because this isdeveloped as a win win solution and his possible implementation in Romanian schools.

  7. Was the stock exchange crisis of 2007 predictable?


    Popescu, Ion; STOICA, Victor; MERUTA, Alexandrina


    The aim is to try to solve the dilemma if could be predictable exchange crisis from 2007 in the conditions of market globalization, including stock exchange, under the risk of system. In such circumstances, the value judgments based on those three major developments (The Big Three) recorded in three representative locations: New York Stock Exchange (NYSE), London Stock Exchange (LSE) and Tokyo Stock Exchange (TSE). The analysis led to a technique conslusion, namely the level of support is a t...

  8. An Empirical Exploration of Exchange Rate Target-Zones


    Donald J Mathieson; Robert P Flood; Andrew K. Rose


    In the context of a flexible-price monetary exchange rate model and the assumption of uncovered interest parity, we obtain a measure of the fundamental determinant of exchange rates. Daily data for the European Monetary System are used to explore the importance of non-linearities in the relationship between the exchange rates and fundamentals. Many implications of existing "target-zone" exchange rate models are tested; little support is found for existing non-linear models of limited exchange...

  9. On the macroeconomic causes of exchange rates volatility


    Claudio Morana


    What are the causes of exchange rate volatility? When second moments implications of theories of exchange rates determination are considered, long-term fundamental linkages between macroeconomic and exchange rate volatility can be envisaged. Moreover, as the exchange rate is an important determinant of aggregate demand, bidirectional causality should be expected. The results of the paper support the above intuitions pointing to important linkages and trade-offs relating exchange rate and macr...

  10. A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing. (United States)

    Ferrante, Andrea; Gorski, Jack


    The mechanism of HLA-DM (DM) activity is still unclear. We have shown that DM-mediated peptide release from HLA-DR (DR) is dependent on the presence of exchange peptide. However, DM also promotes a small amount of peptide release in the absence of exchange peptide. Here we show that SDS-PAGE separates purified peptide/DR1 complexes (pDR1) into two conformers whose ratio is peptide K(d)-dependent. In the absence of exchange peptide, DM only releases peptide from the slower migrating conformer. Addition of exchange peptide converts the DM-resistant conformer to the slower migrating conformer, which is DM labile. Thus, exchange peptide generates a conformer of pDR1 which constitutes the intermediate for peptide exchange and the substrate for DM activity. The resolution of the intermediate favors the highest affinity peptide. However, once folded into the DM-resistant conformer, even low affinity peptides can be presented in the absence of free peptide, broadening the repertoire available for presentation.

  11. Analytical Aspects of Hydrogen Exchange Mass Spectrometry (United States)

    Engen, John R.; Wales, Thomas E.


    This article reviews the analytical aspects of measuring hydrogen exchange by mass spectrometry (HX MS). We describe the nature of analytical selectivity in hydrogen exchange, then review the analytical tools required to accomplish fragmentation, separation, and the mass spectrometry measurements under restrictive exchange quench conditions. In contrast to analytical quantitation that relies on measurements of peak intensity or area, quantitation in HX MS depends on measuring a mass change with respect to an undeuterated or deuterated control, resulting in a value between zero and the maximum amount of deuterium that can be incorporated. Reliable quantitation is a function of experimental fidelity and to achieve high measurement reproducibility, a large number of experimental variables must be controlled during sample preparation and analysis. The method also reports on important qualitative aspects of the sample, including conformational heterogeneity and population dynamics.

  12. Forging Colloidal Nanostructures via Cation Exchange Reactions (United States)


    Among the various postsynthesis treatments of colloidal nanocrystals that have been developed to date, transformations by cation exchange have recently emerged as an extremely versatile tool that has given access to a wide variety of materials and nanostructures. One notable example in this direction is represented by partial cation exchange, by which preformed nanocrystals can be either transformed to alloy nanocrystals or to various types of nanoheterostructures possessing core/shell, segmented, or striped architectures. In this review, we provide an up to date overview of the complex colloidal nanostructures that could be prepared so far by cation exchange. At the same time, the review gives an account of the fundamental thermodynamic and kinetic parameters governing these types of reactions, as they are currently understood, and outlines the main open issues and possible future developments in the field. PMID:26891471


    Directory of Open Access Journals (Sweden)

    Hisao Kumamoto


    Full Text Available This study investigates the impacts of the degree of currency substitution on nominal exchange rate volatility in seven countries (Indonesia, the Philippines, the Czech Republic, Hungary, Poland, Argentina, and Peru. We use the Threshold ARCH model to consider the ratchet effect of currency substitution and sample periods in the 2000s, during which time the economies of the sample countries stabilized, while the U.S. dollar and euro depreciated against other major currencies following the recent global financial crisis. The presented empirical analyses show that the degree of currency substitution has significant positive effects on the conditional variance of the depreciation rate of the nominal exchange rate in most sample countries. Moreover, a shock to the depreciation rate of the nominal exchange rate has asymmetric effects on the conditional variance, depending on the sign. One possible explanation for these differential effects is the existence of the ratchet effect of currency substitution.

  14. Firm-Specific Foreign Exchange Exposure Identification

    DEFF Research Database (Denmark)

    Aabo, Tom; Brodin, Danielle


    -financial firms and find limited consistency in the detected exchange rate exposures when altering methodology in terms of observation frequency and choice of market index. The results put a question mark to the validity of the stock market approach for exchange rate exposure identification at the firm......Previous studies have used the stock market approach to find the aggregate number of (firms with) foreign exchange exposures in a given country, region, or industry. Methodologies have differed in many aspects but two of the most basic differences relate to observation frequency and the choice...... of market index. Aggregate numbers have been shown to be (marginally) sensitive to the methodology employed. However, a corporate manager, an investor, or a stock analyst following a specific firm is not interested in the sensitivity on an aggregated level but on a firm-specific level. If the results...

  15. Brayton-cycle heat exchanger technology program (United States)

    Killackey, J. J.; Coombs, M. G.; Graves, R. F.; Morse, C. J.


    The following five tasks designed to advance this development of heat exchanger systems for close loop Brayton cycle power systems are presented: (1) heat transfer and pressure drop data for a finned tubular heat transfer matrix. The tubes are arranged in a triangular array with copper stainless steel laminate strips helically wound on the tubes to form a disk fin geometry; (2) the development of a modularized waste heat exchanger. Means to provide verified double containment are described; (3) the design, fabrication, and test of compact plate fin heat exchangers representative of full scale Brayton cycle recuperators; (4) the analysis and design of bellows suitable for operation at 1600 F and 200 psia for 1,000 cycles and 50,000 hours creep life; and (5) screening tests used to select a low cost braze alloy with the desirable attributes of a gold base alloy. A total of 22 different alloys were investigated; the final selection was Nicrobraz 30.

  16. Nanomodified polymer materials for regenerative heat exchangers (United States)

    Shchegolkov, Alexander; Shchegolkov, Alexey; Dyachkova, Tatyana


    The paper presents thermophysical properties of nanomodified paraffin mixed with polymers as polyethylene or fluoroplastic, which may be effectively used for the development of heat exchange elements of personal protective equipment. It has been experimentally shown that the heat exchangers based on the nanomodified polymer composites have twofold mass compared to the standard regenerative heat exchanger with comparable dimensions. The best result has been obtained on the basis of composite containing polyethylene and paraffin modified with CNTs, which thermal conductivity is 1.6 times higher than forconventional paraffin. The application of carbon nanostructures as the modifiers of heat storage materials improves cooling efficiency by 14.9-17.9 °C by creating more comfortable conditions for breathing via personal protective equipment.

  17. Extending exchange symmetry beyond bosons and fermions (United States)

    Tichy, Malte C.; Mølmer, Klaus


    We study quantum many-body states of particles subject to a more general exchange symmetry than the behavior under pairwise exchange obeyed by bosons and fermions. We refer to these hypothetical particles as immanons because the scalar product of states with the generalized exchange symmetry is the immanant of the matrix containing all mutual scalar products of the occupied single-particle states, a generalization of the determinant and permanent applied for fermions and bosons. Immanons are shown to obey a partial Pauli principle that forbids the occupation of single-particle states above certain threshold numbers. This has measurable consequences for their tendency to favor or oppose multiple occupation of single-particle modes, and it links conjectured mathematical properties of immanants to the expected outcome of a physical Gedanken experiment.

  18. A distributed framework for health information exchange using smartphone technologies. (United States)

    Abdulnabi, Mohamed; Al-Haiqi, Ahmed; Kiah, M L M; Zaidan, A A; Zaidan, B B; Hussain, Muzammil


    Nationwide health information exchange (NHIE) continues to be a persistent concern for government agencies, despite the many efforts and the conceived benefits of sharing patient data among healthcare providers. Difficulties in ensuring global connectivity, interoperability, and concerns on security have always hampered the government from successfully deploying NHIE. By looking at NHIE from a fresh perspective and bearing in mind the pervasiveness and power of modern mobile platforms, this paper proposes a new approach to NHIE that builds on the notion of consumer-mediated HIE, albeit without the focus on central health record banks. With the growing acceptance of smartphones as reliable, indispensable, and most personal devices, we suggest to leverage the concept of mobile personal health records (PHRs installed on smartphones) to the next level. We envision mPHRs that take the form of distributed storage units for health information, under the full control and direct possession of patients, who can have ready access to their personal data whenever needed. However, for the actual exchange of data with health information systems managed by healthcare providers, the latter have to be interoperable with patient-carried mPHRs. Computer industry has long ago solved a similar problem of interoperability between peripheral devices and operating systems. We borrow from that solution the idea of providing special interfaces between mPHRs and provider systems. This interface enables the two entities to communicate with no change to either end. The design and operation of the proposed approach is explained. Additional pointers on potential implementations are provided, and issues that pertain to any solution to implement NHIE are discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Foreign Exchange Risk in International Transactions

    Directory of Open Access Journals (Sweden)

    Florentina-Olivia Balu


    Full Text Available Every international business is affected by the ever-changing value of the currencies implied in contracts. While many of us consider this unpredictability a nuisance, the volatility of currencies around the world can mean the difference between success and failure for many exporters/importers. Exchange rates between one currency and another can change dramatically in a short period of time, leaving the unprepared business exposed to potentially crippling losses. The efficient management of this risk is essential for the survival of a company and any business that is exposed to such a risk should ensure that it is fully prepared to manage it. Old standbys and recent breakthroughs in the area of financial risk management can remove much of the risk from currency rate movements. The range of such products is huge, with increasingly sophisticated techniques constantly being added. Among the most modern methods for managing exchange risk there are four major classes of derivative products like: forwards, futures, options, and swaps. Beyond the four main types of risk management instruments, there are a number of other products including "swaptions" (options on swaps; avenging options; yield curve swaps; futures on spreads; and options on portfolios. Sophisticated mathematical tools and high-speed computers are needed to calculate the price of these instruments and to determine their overall effect on the company. In this article we will focus on forward and futures contracts for managing foreign exchange risk. A forward is a contract to buy or sell currency at an agreed upon exchange rate at a specific date in the future. Futures are similar to forwards except that they're traded on exchanges which specify settlement dates. Also we make some recommendations related to the foreign exchange risk-management practices that are useful for companies involved in international trade and for financial institutions interested in providing hedging products to

  20. Self-organized key management with trusted certificate exchange in MANET

    Directory of Open Access Journals (Sweden)

    Saju P John


    Full Text Available In MANET, security is more challenging due to problems related to key exchange. It is necessary to secure the exchanges in MANETs for assuring the development of services in the network. The self-organized MANET is visualized as a key communication technology enabler for application such as network centric warfare, disaster relief operations, emergency situations, and intelligent transportation systems. In this paper, we propose a self-organized key management technique coupled with trusted certificate exchange for mobile ad hoc networks. The proposed architecture consists of one coordinator node, servers and normal mobile nodes. The coordinator acts as a mediator for transmitting the message among the servers and mobile nodes. Each node generates its own public/private key pairs using server-signed public keying technique. Then multi-path certificate exchange technique is employed where public key of the nodes is certified by different nodes. Those nodes that issued the certificates are validated using the Eigen Vector Reputation Centrality. By simulation results, we show that the proposed approach improves security.

  1. Cell contact-dependent outer membrane exchange in myxobacteria: genetic determinants and mechanism.

    Directory of Open Access Journals (Sweden)

    Darshankumar T Pathak

    Full Text Available Biofilms are dense microbial communities. Although widely distributed and medically important, how biofilm cells interact with one another is poorly understood. Recently, we described a novel process whereby myxobacterial biofilm cells exchange their outer membrane (OM lipoproteins. For the first time we report here the identification of two host proteins, TraAB, required for transfer. These proteins are predicted to localize in the cell envelope; and TraA encodes a distant PA14 lectin-like domain, a cysteine-rich tandem repeat region, and a putative C-terminal protein sorting tag named MYXO-CTERM, while TraB encodes an OmpA-like domain. Importantly, TraAB are required in donors and recipients, suggesting bidirectional transfer. By use of a lipophilic fluorescent dye, we also discovered that OM lipids are exchanged. Similar to lipoproteins, dye transfer requires TraAB function, gliding motility and a structured biofilm. Importantly, OM exchange was found to regulate swarming and development behaviors, suggesting a new role in cell-cell communication. A working model proposes TraA is a cell surface receptor that mediates cell-cell adhesion for OM fusion, in which lipoproteins/lipids are transferred by lateral diffusion. We further hypothesize that cell contact-dependent exchange helps myxobacteria to coordinate their social behaviors.

  2. Application of Plasma Exchange in Patients with History of Unexplained Recurrent Abortion: A Case Series

    Directory of Open Access Journals (Sweden)

    Azadeh Ghaheri


    Full Text Available Background: Immune-mediated recurrent pregnancy loss (RPL has received more attentionthan any other single etiologic classification. Individuals with rare blood group P have an antipp1pkantibody in their serum, which causes recurrent abortion in the early stages.Materials and Methods: In this case series study, 11 patients with unexplained RPL whohad anti-P antibody in their serum were treated by plasma exchange during their nextpregnancies. To evaluate the efficacy of the treatment, we monitored fetal developmentusing ultrasonography and intensive prenatal care. All calculations were performed withthe SPSS version 16.Results: All patients who were treated by plasma exchange progressed to live birth. Themean gestational age at the time of termination was 37.5 ± 0.69 weeks. The mean weightof the newborns was 2729.09 ± 389.88 g. None of the newborns required exchange transfusion.Conclusion: P-incompatibility is one rare but important cause of unexplained RPL and also abasis for therapeutic intervention via early antibody removal by plasma exchange.

  3. 77 FR 18309 - Patient Protection and Affordable Care Act; Establishment of Exchanges and Qualified Health Plans... (United States)


    ... Protection and Affordable Care Act; Establishment of Exchanges and Qualified Health Plans; Exchange Standards... Qualified Health Plans; Exchange Standards for Employers AGENCY: Department of Health and Human Services..., 2011 rule titled Establishment of Exchanges and Qualified Health Plans (``Exchange establishment...

  4. Integration of Heat Exchangers with Thermoelectric Modules

    DEFF Research Database (Denmark)

    Rezaniakolaei, Alireza


    thermally interdependent in the system designs. This chapter studies the effect of the heat exchangers design on system performance, and discusses the challenges through accurate analyses techniques while introducing proper cooling technologies. Proper design of a TEG system involves design optimization...... processes wherein the critical system components such as the TEG module and the heat exchangers are thermally coupled. The optimization techniques of the TEG systems coupled with the heat transfer through the system using a maximum efficiency-power map for waste heat recovery applications offer maximum...

  5. Observer-based monitoring of heat exchangers. (United States)

    Astorga-Zaragoza, Carlos-Manuel; Alvarado-Martínez, Víctor-Manuel; Zavala-Río, Arturo; Méndez-Ocaña, Rafael-Maxim; Guerrero-Ramírez, Gerardo-Vicente


    The goal of this work is to provide a method for monitoring performance degradation in counter-flow double-pipe heat exchangers. The overall heat transfer coefficient is estimated by an adaptive observer and monitored in order to infer when the heat exchanger needs preventive or corrective maintenance. A simplified mathematical model is used to synthesize the adaptive observer and a more complex model is used for simulation. The reliability of the proposed method was demonstrated via numerical simulations and laboratory experiments with a bench-scale pilot plant.

  6. Word Exchange at the Gates of Europe

    DEFF Research Database (Denmark)

    Hyllested, Adam

    that took place. By the time of arrival in Europe, the Indo-European and Uralic populations had already broken up and constituted a patchwork of languages and cultures that continued to converge and exchange. Whether contacts were connected to war or trade or exchange of inventions is revealed...... to Medieval times. The Indo-European tribes, shortly after their migrations into Europe, came to form part of new cultural communities, influenced by Uralic populations from the North. This had a significant impact on specific parts of the vocabulary, notably terms for religion and warfare. Many terms...

  7. Spin-Exchange Pumped NMR Gyros

    CERN Document Server

    Walker, Thad G


    We present the basic theory governing spin-exchange pumped NMR gyros. We review the basic physics of spin-exchange collisions and relaxation as they pertain to precision NMR. We present a simple model of operation as an NMR oscillator and use it to analyze the dynamic response and noise properties of the oscillator. We discuss the primary systematic errors (differential alkali fields, quadrupole shifts, and offset drifts) that limit the bias stability, and discuss methods to minimize them. We give with a brief overview of a practical implementation and performance of an NMR gyro built by Northrop-Grumman Corporation, and conclude with some comments about future prospects.

  8. Gifts and exchanges problems, frustrations, and triumphs

    CERN Document Server

    Katz, Linda S; Denning, Catherine


    This important book explores the many questions challenging librarians who work with gifts and exchanges (G&E) as part of their daily responsibilities. Too often, because of shrinking library budgets, library gifts are considered burdensome and unprofitable drains on both financial and personnel resources. However, Gifts and Exchanges: Problems, Frustrations, . . . and Triumphs gives you solutions that will allow you to embrace your library's gifts as rewards. In this book, you will discover the latest ways of disposing unwanted materials, planning and holding book sales and auctions, and oper

  9. Hard Colour Singlet Exchange at the Tevatron

    CERN Document Server

    Cox, Brian; Lonnblad, Leif; Cox, Brian; Forshaw, Jeff; Lonnblad, Leif


    We have performed a detailed phenomenological investigation of the hard colour singlet exchange process which is observed at the Tevatron in events which have a large rapidity gap between outgoing jets. We include the effects of multiple interactions to obtain a prediction for the gap survival factor. Comparing the data on the fraction of gap events with the prediction from BFKL pomeron exchange we find agreement provided that a constant value of alpha_s is used in the BFKL calculation. Moreover, the value of alpha_s is in line with that extracted from measurements made at HERA.

  10. Oxygen exchange in silicone rubber capillaries. (United States)

    Heineken, F G; Predecki, P K; Filley, G F


    Capillaries of 7 and 12.5 mu diameter have been fabricated in silicone rubber. Whole blood treated with heparin has been perfused through these capillaries. Under flowing conditions, no clotting or other clumping effects have been observed and red cells appear to maintain a constant velocity. Oxygen transfer data to and from saline perfusing the 12.5 mu diameter capillaries have been obtained in order to determine how rapidly O2 will permeate the silicone rubber film. The data indicate that the capillaries simulate lung tissue oxygen exchange and will allow for the first time the experimental determination of oxygen exchange kinetics in flowing whole blood.

  11. Brazilian exchange rate complexity: Financial crisis effects (United States)

    Piqueira, José Roberto C.; Mortoza, Letícia Pelluci D.


    With the financial market globalization, foreign investments became vital for the economies, mainly in emerging countries. In the last decades, Brazilian exchange rates appeared as a good indicator to measure either investors' confidence or risk aversion. Here, some events of global or national financial crisis are analyzed, trying to understand how they influenced the "dollar-real" rate evolution. The theoretical tool to be used is the López-Mancini-Calbet (LMC) complexity measure that, applied to real exchange rate data, has shown good fitness between critical events and measured patterns.

  12. A simple asynchronous replica-exchange implementation

    CERN Document Server

    Bussi, Giovanni


    We discuss the possibility of implementing asynchronous replica-exchange (or parallel tempering) molecular dynamics. In our scheme, the exchange attempts are driven by asynchronous messages sent by one of the computing nodes, so that different replicas are allowed to perform a different number of time-steps between subsequent attempts. The implementation is simple and based on the message-passing interface (MPI). We illustrate the advantages of our scheme with respect to the standard synchronous algorithm and we benchmark it for a model Lennard-Jones liquid on an IBM-LS21 blade center cluster.

  13. Properties of Foreign Exchange Risk Premiums

    DEFF Research Database (Denmark)

    Sarno, Lucio; Schneider, Paul; Wagner, Christian


    We study the properties of foreign exchange risk premiums that can explain the forward bias puzzle, defined as the tendency of high-interest rate currencies to appreciate rather than depreciate. These risk premiums arise endogenously from the no-arbitrage condition relating the term structure...... of interest rates and exchange rates. Estimating affine (multi-currency) term structure models reveals a noticeable tradeoff between matching depreciation rates and accuracy in pricing bonds. Risk premiums implied by our global affine model generate unbiased predictions for currency excess returns...

  14. Hadron Spectroscopy in Double Pomeron Exchange Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Albrow, Michael [Fermilab


    Central exclusive production in hadron-hadron collisions at high energies, for example p + p -> p + X + p, where the "+" represents a large rapidity gap, is a valuable process for spectroscopy of mesonic states X. At collider energies the gaps can be large enough to be dominated by pomeron exchange, and then the quantum numbers of the state X are restricted. Isoscalar JPC = 0++ and 2++ mesons are selected, and our understanding of these spectra is incomplete. In particular, soft pomeron exchanges favor gluon-dominated states such as glueballs, which are expected in QCD but not yet well established. I will review some published data.

  15. Hadron spectroscopy in double pomeron exchange experiments (United States)

    Albrow, Michael G.


    Central exclusive production in hadron-hadron collisions at high energies, for example p + p → p + X + p, where the + represents a large rapidity gap, is a valuable process for spectroscopy of mesonic states X. At collider energies the gaps can be large enough to be dominated by pomeron exchange, and then the quantum numbers of the state X are restricted. Isoscalar JPC = 0++ and 2++ mesons are selected, and our understanding of these spectra is incomplete. In particular, soft pomeron exchanges favor gluon-dominated states such as glueballs, which are expected in QCD but not yet well established. I will review some published data.

  16. Exchange rate arrangements: From extreme to "normal"

    Directory of Open Access Journals (Sweden)

    Beker Emilija


    Full Text Available The paper studies theoretical and empirical location dispersion of exchange rate arrangements - rigid-intermediate-flexible regimes, in the context of extreme arrangements of a currency board, dollarization and monetary union moderate characteristics of intermediate arrangements (adjustable pegs crawling pegs and target zones and imperative-process "normalization" in the form of a managed or clean floating system. It is established that de iure and de facto classifications generate "fear of floating" and "fear of pegging". The "impossible trinity" under the conditions of capital liberalization and globalization creates a bipolar view or hypothesis of vanishing intermediate exchange rate regimes.

  17. Research of characteristics slot-hole heat exchanger with the developed surface of heat exchange

    Directory of Open Access Journals (Sweden)

    Malkin E. C.


    Full Text Available Thermal characteristics of multichannel slot-hole heat exchanger with the developed surface of heat exchange inside the opened-cycle water cooling system are experimentally investigated. Graphic dependences of average value of temperature of the simulator of a heat current and temperatures of the heat exchanger base are presented on tapped-off power. Dependences of tapped-off power and hydraulic losses on the of water consumption are given. It is shown, that use of developed slot-hole heat exchanger provides higher values of tapped-off power as compared to well-known two-channel slot-hole heat exchanger: at the temperature of heat-generating component simulator of +60°С the tapped-off power increases with 307 up to 750 W. Recommendations on increase of adaptability of slot-hole heat exchanger manufacturing are given. Heat exchanger is suitable for application in microprocessors and others heat-generating components and electronic equipment units cooling.

  18. Adolescent erythrocytes: influence of high density lipoproteins-cholesterol (HDL-c) plasmatic levels on Na+/Li+ exchange kinetics. (United States)

    Serrani, Raquel; Taborda, Diego; DeMaria, Ines; Corchs, Juan


    An inverse relationship between HDL-c plasmatic levels and Li+ flux (Na+-Li+ exchange mediated) has been reported in normotensive individuals with hypertensive ancestors as well as in essential hypertensive subjects. This lipoprotein reaction with plasmatic membrane components induces modifications in membrane transport mechanisms as well as in cellular enzymes. In this paper we present data on Li+ flux (Na+-Li+ exchange mediated) in red blood cells from normotensive individuals without hypertensive ancestors. Kinetic analysis of Li+ efflux as a function of Na+(extracell) concentration was carried out. Vmax and Km values were determined. HDL-c plasmatic levels were also determined. Vmax showed a significant inverse correlation with HDL-c levels. No significant correlation of Km values with HDL-c levels was observed. The data presented support previous data showing that variable Vmax is sensitive to cellular environmental factors. Otherwise the Km variable not influenced by these factors is sensitive to hereditary influences.

  19. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells

    NARCIS (Netherlands)

    Rondaij, Mariska G.; Bierings, Ruben; van Agtmaal, Ellen L.; Gijzen, Karina A.; Sellink, Erica; Kragt, Astrid; Ferguson, Stephen S. G.; Mertens, Koen; Hannah, Matthew J.; van Mourik, Jan A.; Fernandez-Borja, Mar; Voorberg, Jan


    The small GTP-binding protein Ral has been implicated in regulated exocytosis via its interaction with the mammalian exocyst complex. We have previously demonstrated that Ral is involved in exocytosis of Weibel-Palade bodies (WPBs). Little is known about intracellular signaling pathways that promote

  20. Counterion-Mediated Ligand Exchange for PbS Colloidal Quantum Dot Super lattices

    NARCIS (Netherlands)

    Balazs, Daniel M.; Dirin, Dmitry N.; Fang, Honghua; Protesescu, Loredana; ten Brink, Gert H.; Kooi, Bart J.; Kovalenko, Maksym V.; Loi, Maria Antonietta


    In the past years, halide capping became one of the most promising strategies to passivate the surface of colloidal quantum dots (CQDs) in thin films to be used for electronic and optoelectronic device fabrication. This is due to the convenient processing, strong n-type characteristics, and ambient

  1. Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms (United States)

    Widdows, Kate L.; Panitchob, Nuttanont; Crocker, Ian P.; Please, Colin P.; Hanson, Mark A.; Sibley, Colin P.; Johnstone, Edward D.; Sengers, Bram G.; Lewis, Rohan M.; Glazier, Jocelyn D.


    Uptake of system L amino acid substrates into isolated placental plasma membrane vesicles in the absence of opposing side amino acid (zero-trans uptake) is incompatible with the concept of obligatory exchange, where influx of amino acid is coupled to efflux. We therefore hypothesized that system L amino acid exchange transporters are not fully obligatory and/or that amino acids are initially present inside the vesicles. To address this, we combined computational modeling with vesicle transport assays and transporter localization studies to investigate the mechanisms mediating [14C]l-serine (a system L substrate) transport into human placental microvillous plasma membrane (MVM) vesicles. The carrier model provided a quantitative framework to test the 2 hypotheses that l-serine transport occurs by either obligate exchange or nonobligate exchange coupled with facilitated transport (mixed transport model). The computational model could only account for experimental [14C]l-serine uptake data when the transporter was not exclusively in exchange mode, best described by the mixed transport model. MVM vesicle isolates contained endogenous amino acids allowing for potential contribution to zero-trans uptake. Both L-type amino acid transporter (LAT)1 and LAT2 subtypes of system L were distributed to MVM, with l-serine transport attributed to LAT2. These findings suggest that exchange transporters do not function exclusively as obligate exchangers.—Widdows, K. L., Panitchob, N., Crocker, I. P., Please, C. P., Hanson, M. A., Sibley, C. P., Johnstone, E. D., Sengers, B. G., Lewis, R. M., Glazier, J. D. Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms. PMID:25761365

  2. Immune-Mediated Diseases II Congress: summary. (United States)

    Shurin, Michael R; Smolkin, Yury S


    The remarkable progress in basic immunological research during the past 50 years can account for the emerging of medical or clinical immunology as a novel discipline, which may be defined as the application of basic immunology rules to the diagnosis, treatment, and prophylactics of patients with diseases in which immunological pathways may play an important etiological and/or pathogenetic role. The immune system has a central role not only in fighting infections, but also in many other diseases and disorders including cancer, AIDS, and organ transplantation. In addition, the immune system imbalance is responsible for primary and secondary immunodeficiencies, hypersensitive illnesses, such as asthma, dermatitis, and other allergies, as well as systemic and organ-specific autoimmune disorders, such as multiple sclerosis, lupus, rheumatoid arthritis and diabetes. Immune-mediated diseases such as autoimmune diseases and allergic diseases are important health problems in many countries. For instance, autoimmune diseases afflict up to 8% of the United States population; allergic diseases represent the sixth leading cause of chronic illness and disability in the United States, and the leading cause among children. Thus, immune-mediated diseases represent an enormous medical, social, and economical problem and require serious and instant attention from clinicians, scientists, pharmacists, and biotech professionals. The goal of the Second International Immune-Mediated Diseases (IMD) Congress was to advance medical and biomedical immunological sciences and clinical practice via the organization of multiple sessions and training courses as well as providing an environment for stimulating scientific discussions, the exchange of ideas, and consideration of novel clinical diagnostic and therapeutic approaches. Selected contributions from the participants of this Congress who are eager to share some of the academic and clinical enthusiasm are presented in this issue (and the

  3. "I'm* Two Rabbits" / "J'ai un Rouge Pullover*". How Corrective Feedback Is Handled in Collaborative Exchange Programmes between Early Language Learners (United States)

    Choffat-Durr, Anne; Macaire, Dominique


    This article presents how, in the social dynamics of two classrooms involved in an exchange programme, young learners provide their peers with asynchronous feedback taking place in the digital medium. Within two Call Triangles that interact thanks to Computer Mediated Communication tools, teachers sharing the same methodological precept on…

  4. The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium

    DEFF Research Database (Denmark)

    Schneider, Linda; Stock, Christian-Martin; Dieterich, Peter


    We previously demonstrated that the primary cilium coordinates platelet-derived growth factor (PDGF) receptor (PDGFR) alpha-mediated migration in growth-arrested fibroblasts. In this study, we investigate the functional relationship between ciliary PDGFR-alpha and the Na(+)/H(+) exchanger NHE1 in...

  5. Antiferromagnetic exchange spring as the reason of exchange bias training effect (United States)

    Dobrynin, A. N.; Maccherozzi, F.; Dhesi, S. S.; Fan, R.; Bencok, P.; Steadman, P.


    We observe recovery of the exchange bias training effect in a Co/CoO bilayer after warming the sample up to the blocking temperature and cooling it back to a low measuring temperature in zero magnetic field. Variation of the magnitude of X-ray magnetic linear dichroism in the sample for the system in the high unidirectional anisotropy state (after field cooling) and in the low unidirectional anisotropy state (after training) suggests rearrangement of antiferromagnetic structure during the initial field cycling in exchange biased state. Our results suggest formation of an antiferromagnetic exchange spring at the frustrated ferromagnetic-antiferromagnetic interface being the reason of the training effect.

  6. An improved 2-agent kidney exchange mechanism

    DEFF Research Database (Denmark)

    Caragiannis, Ioannis; Filos-Ratsikas, Aris; Procaccia, Ariel D.


    We study a mechanism design version of matching computation in graphs that models the game played by hospitals participating in pairwise kidney exchange programs. We present a new randomized matching mechanism for two agents which is truthful in expectation and has an approximation ratio of 3...

  7. Analysis of a Flooded Heat Exchanger (United States)

    Fink, Aaron H.; Luyben, William L.


    Flooded heat exchangers are often used in industry to reduce the required heat-transfer area and the size of utility control valves. These units involve a condensing vapor on the hot side that accumulates as a liquid phase in the lower part of the vessel. The heat transfer occurs mostly in the vapor space, but the condensate becomes somewhat…

  8. Measurement of heat and moisture exchanger efficiency. (United States)

    Chandler, M


    Deciding between a passive heat and moisture exchanger or active humidification depends upon the level of humidification that either will deliver. Published international standards dictate that active humidifiers should deliver a minimum humidity of 33 mg.l(-1); however, no such requirement exists, for heat and moisture exchangers. Anaesthetists instead have to rely on information provided by manufacturers, which may not allow comparison of different devices and their clinical effectiveness. I suggest that measurement of humidification efficiency, being the percentage moisture returned and determined by measuring the temperature of the respired gases, should be mandated, and report a modification of the standard method that will allow this to be easily measured. In this study, different types of heat and moisture exchangers for adults, children and patients with a tracheostomy were tested. Adult and paediatric models lost between 6.5 mg.l(-1) and 8.5 mg.l(-1) moisture (corresponding to an efficiency of around 80%); however, the models designed for patients with a tracheostomy lost between 16 mg.l(-1) and 18 mg.l(-1) (60% efficiency). I propose that all heat and moisture exchangers should be tested in this manner and percentage efficiency reported to allow an informed choice between different types and models. © 2013 The Association of Anaesthetists of Great Britain and Ireland.

  9. Universal exchange-driven phonon splitting (United States)

    Deisenhofer, Joachim; Kant, Christian; Schmidt, Michael; Wang, Zhe; Mayr, Franz; Tsurkan, Vladimir; Loidl, Alois


    We report on a linear dependence of the phonon splitting on the non-dominant exchange coupling Jnd in the antiferromagnetic monoxides MnO, Fe0.92O, CoO and NiO, and in the highly frustrated antiferromagnetic spinels CdCr2O4, MgCr2O4 and ZnCr2O4. For the monoxides our results directly confirm the theoretical prediction of a predominantly exchange induced splitting of the zone-centre optical phonon [1,2]. We find the linear relation δφ= βJndS^2 with slope β = 3.7. This relation also holds for a very different class of systems, namely the highly frustrated chromium spinels. Our finding suggests a universal dependence of the exchange-induced phonon splitting at the antiferromagnetic transition on the non-dominant exchange coupling [3].[4pt] [1] S. Massidda et al., Phys. Rev. Lett. 82, 430 (1999).[0pt] [2] W. Luo et al., Solid State Commun. 142, 504 (2007).[0pt] [3] Ch. Kant et al., arxiv:1109.4809.

  10. 12 CFR 614.4900 - Foreign exchange. (United States)


    ... with relationship to the customer's financial capability to bear the financial risks assumed. The bank..., where such transactions or positions normally reduce risks in the conduct and management of..., liabilities, and foreign exchange contracts. (3) Outstanding contracts with individual customers and banks. (4...

  11. Markets, Distribution, and Exchange after Societal Cataclysm (United States)


    and Space in Egalitarian Sects: A Millenarian Cosmology ," in M. Douglas, Essays in the Sociology of Perception, Routledge and Kegan Paul, London, 1982...Strathern, Andrew, The Rope of Moka: Big-men and Ceremonial Exchange in Mount Hagen, Cambridge University Press, Cambridge, 1971. Susskind , Lawrence E

  12. Double Pomeron Exchange: the early years

    Energy Technology Data Exchange (ETDEWEB)

    Albrow, Michael G. [Fermilab


    I review the early experimental searches for double pomeron exchange, the first observations at the CERN Intersecting Storage Rings (ISR) and further studies at the SPS and Tevatron (fixed target). I only have space for a superficial coverage of some highlights, and will not cover later colliders with √s > GeV.

  13. Ligand Exchange Kinetics of Environmentally Relevant Metals

    Energy Technology Data Exchange (ETDEWEB)

    Panasci, Adele Frances [Univ. of California, Davis, CA (United States)


    The interactions of ground water with minerals and contaminants are of broad interest for geochemists but are not well understood. Experiments on the molecular scale can determine reaction parameters (i.e. rates of ligand exchange, activation entropy, activation entropy, and activation volume) that can be used in computations to gain insight into reactions that occur in natural groundwaters. Experiments to determine the rate of isotopic ligand exchange for three environmentally relevant metals, rhodium (Rh), iron (Fe), and neptunium (Np), are described. Many environmental transformations of metals (e.g. reduction) in soil occur at trivalent centers, Fe(III) in particular. Contaminant ions absorb to mineral surfaces via ligand exchange, and the reversal of this reaction can be dangerous, releasing contaminants into the environment. Ferric iron is difficult to study spectroscopically because most of its complexes are paramagnetic and are generally reactive toward ligand exchange; therefore, Rh(III), which is diamagnetic and less reactive, was used to study substitution reactions that are analogous to those that occur on mineral oxide surfaces. Studies on both Np(V) and Np(VI) are important in their own right, as 237Np is a radioactive transuranic element with a half-life of 2 million years.

  14. Algorithmic Trading at Bucharest Stock Exchange

    Directory of Open Access Journals (Sweden)

    Adrian Victor SĂNDIŢĂ


    Full Text Available Very conservative estimates indicate that over 40% of transactions on the stock exchanges in the United States are based on automatically generated orders. Such systems are designed to do algorithmic trading on the basis of a predefined set of rules that determine the composition of the portfolio and the moment in which the purchases and sales of securities are done. Applying highly diverse trading strategies, algorithmic trading systems ultimately aim to maximize profit and minimize risk taking. Algorithmic trading on the Bucharest Stock Exchange is still in its incipient phase. Now, automated trading systems are used only for participants who act as Market Makers for the actions of a few issuers. Estimates indicate a volume of algorithmic trading on the Bucharest Stock Exchange of under 1% of its total transactions. This paper aims to describe a general way that algorithmic trading systems can be connected to the Bucharest Stock Exchange and to present some of our results in the implementation of such a system.

  15. Water permeation through anion exchange membranes (United States)

    Luo, Xiaoyan; Wright, Andrew; Weissbach, Thomas; Holdcroft, Steven


    An understanding of water permeation through solid polymer electrolyte (SPE) membranes is crucial to offset the unbalanced water activity within SPE fuel cells. We examine water permeation through an emerging class of anion exchange membranes, hexamethyl-p-terphenyl poly (dimethylbenzimidazolium) (HMT-PMBI), and compare it against series of membrane thickness for a commercial anion exchange membrane (AEM), Fumapem® FAA-3, and a series of proton exchange membranes, Nafion®. The HMT-PMBI membrane is found to possess higher water permeabilities than Fumapem® FAA-3 and comparable permeability than Nafion (H+). By measuring water permeation through membranes of different thicknesses, we are able to decouple, for the first time, internal and interfacial water permeation resistances through anion exchange membranes. Permeation resistances on liquid/membrane interface is found to be negligible compared to that for vapor/membrane for both series of AEMs. Correspondingly, the resistance of liquid water permeation is found to be one order of magnitude smaller compared to that of vapor water permeation. HMT-PMBI possesses larger effective internal water permeation coefficient than both Fumapem® FAA-3 and Nafion® membranes (60 and 18% larger, respectively). In contrast, the effective interfacial permeation coefficient of HMT-PMBI is found to be similar to Fumapem® (±5%) but smaller than Nafion®(H+) (by 14%).


    African Journals Online (AJOL)

    For Nigeria at the inception of SAP, a major strategic importance in the nexus of the exchange rate policy was the reduction of the parallel market premium given the existence of the market side by side the official markets. The Hamdala, a group of Hausa `currency sellers' came into existence as a reaction to the need to act ...

  17. Exchange of Identical Particles in Two Dimensions

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 2. Exchange of Identical Particles in Two Dimensions. P Ramadevi. General Article Volume 6 Issue 2 February 2001 pp 23-28. Fulltext. Click here to view fulltext PDF. Permanent link: ...

  18. Developing Intercultural Communicative Competence through Online Exchanges (United States)

    Chun, Dorothy M.


    Based on Byram's (1997) definition of intercultural communicative competence (ICC) and on specific types of discourse analysis proposed by Kramsch and Thorne (2002) and Ware and Kramsch (2005), this article explores how online exchanges can play a role in second language learners' development of pragmatic competence and ICC. With data obtained…

  19. The Foreign Exchange Exposure of Japanese Multinational ...

    African Journals Online (AJOL)

    In this paper, we find that about 25 per cent of our sample of 171 Japanese multinationals stock returns experienced economically significant positive exposure effects for the period January 1979 to December 1993. The extent to which a firm is exposed to exchange rate fluctuations can be explained by the level of its export ...

  20. Exchange of Standardized Flight Dynamics Data (United States)

    Martin-Mur, Tomas J.; Berry, David; Flores-Amaya, Felipe; Folliard, J.; Kiehling, R.; Ogawa, M.; Pallaschke, S.


    Spacecraft operations require the knowledge of the vehicle trajectory and attitude and also that of other spacecraft or natural bodies. This knowledge is normally provided by the Flight Dynamics teams of the different space organizations and, as very often spacecraft operations involve more than one organization, this information needs to be exchanged between Agencies. This is why the Navigation Working Group within the CCSDS (Consultative Committee for Space Data Systems), has been instituted with the task of establishing standards for the exchange of Flight Dynamics data. This exchange encompasses trajectory data, attitude data, and tracking data. The Navigation Working Group includes regular members and observers representing the participating Space Agencies. Currently the group includes representatives from CNES, DLR, ESA, NASA and JAXA. This Working Group meets twice per year in order to devise standardized language, methods, and formats for the description and exchange of Navigation data. Early versions of some of these standards have been used to support mutual tracking of ESA and NASA interplanetary spacecraft, especially during the arrival of the 2003 missions to Mars. This paper provides a summary of the activities carried out by the group, briefly outlines the current and envisioned standards, describes the tests and operational activities that have been performed using the standards, and lists and discusses the lessons learned from these activities.