WorldWideScience

Sample records for excellent local control

  1. Malignant melanoma and radiotherapy: Past myths, excellent local control in 146 studied lesions at Georgetown University, and improving future management

    Directory of Open Access Journals (Sweden)

    Pooya eJahanshahi

    2012-11-01

    Full Text Available Introduction: Once thought to be radioresistant, emerging cellular and clinical evidence now suggests melanoma can respond to large radiation doses per fraction.Materials and Methods: We conducted a retrospective study of all patients treated with stereotactic radiosurgery and stereotactic body radiotherapy at Georgetown University Hospital from May 2002 through November 2008 and studied the classic Extrapolated Total Dose Corrected for Volume (ETDvol model for predicting melanoma tumor response. Region-specific tumor outcomes were categorized by RECIST criteria and local control curves were estimated and analyzed when stratified by ETDvol thresholds by use of the Kaplan-Meier method.Results: Follow-up information was available for 78 lesions (49 intracranial, 8 spinal, and 21 body with mean follow-up period of 9.2 (range, 2-36 months. 1-year local control rates for intracranial, spinal, and body tumors were 84%, 100%, and 72% respectively. Treatments in general were well-tolerated. Increased ETDvol (p<0.001 among intracranial sites resulted from larger (p<0.001 doses per fraction combined with smaller (p<0.001 tumor diameters. Intracranial 6-, 12-, and 24-month local control rates when treated above ETDvol threshold of 230 Gy were all 90% vs. 89%, 80%, and 53% below this threshold. Body 6- and 12-month local control rates when treated above ETDvol threshold of 100 Gy were 100% and 80% vs. 74% and 59% below this threshold. Discussion: By tailoring to melanoma’s unique radiobiology with large radiation doses per fraction, favorable local control was safely achieved. The ETDvol model combines the important factor of dose per fraction in melanoma treatment with a volume correction factor to predict tumor response. Although limited sample size may have prevented reaching statistical significance for local control improvements using ETDvol thresholds, optimal thresholds may exist to improve future tumor responses and further research is required.

  2. An Excel Add-In for Statistical Process Control Charts

    Directory of Open Access Journals (Sweden)

    Samuel E. Buttrey

    2009-06-01

    Full Text Available t shifts in processes in, for example, manufacturing. Among these are control charts".Control charts and other SPC techniques have been in use since at least the 1950s, and,because they are comparatively unsophisticated, are often used by management or op-erations personnel without formal statistical training. These personnel will often haveexperience with the popular spreadsheet program Excel, but may have less training on amainstream statistical package. Base Excel does not provide the ability to draw controlcharts directly, although add-ins for that purpose are available for purchase.We present a free add-in for Excel that draws the most common sorts of control charts.It follows the development of the textbook of Montgomery (2005, so it may be well-suited for instructional purposes.

  3. An improved solution of local window parameters setting for local singularity analysis based on Excel VBA batch processing technology

    Science.gov (United States)

    Zhang, Daojun; Cheng, Qiuming; Agterberg, Frits; Chen, Zhijun

    2016-03-01

    In this paper Excel VBA is used for batch calculation in Local Singularity Analysis (LSA), which is for the information extracting from different kinds of geoscience data. Capabilities and advantages of a new module called Batch Tool for Local Singularity Index Mapping (BTLSIM) are: (1) batch production of series of local singularity maps with different settings of local window size, shape and orientation parameters; (2) local parameter optimization based on statistical tests; and (3) provision of extra output layers describing how spatial changes induced by parameter optimization are related to spatial structure of the original input layers.

  4. [Construction of abridged life table for health evaluation of local resident using Excel program].

    Science.gov (United States)

    Chen, Qingsha; Wang, Feng; Li, Xiaozhen; Yang, Jian; Yu, Shouyi; Hu, Jun

    2012-05-01

    To provide an easy computational tool for evaluating the health condition of local residents. An abridged life table was programmed by applying mathematical functions and formula in Excel program and tested with the real study data to evaluate the results computed. The Excel was capable of computing group death probability of age in the life table ((n)q(x)), number of survivors (l(x)), number of death ((n)d(x)), survival per person-year ((n)L(x)), survival total per person-year (T(x)) and life expectancy (e(x)). The calculated results were consistent with those by SAS. The abridged life table constructed using Microsoft Excel can conveniently and accurately calculate the relevant indices for evaluating the health condition of the residents.

  5. Aging in Sweden: local variation, local control.

    Science.gov (United States)

    Davey, Adam; Malmberg, Bo; Sundström, Gerdt

    2014-08-01

    Aging in Sweden has been uniquely shaped by its history-most notably the long tradition of locally controlled services for older adults. We considered how local variations and local control shape the experience of aging in Sweden and organized the paper into 3 sections. First, we examine aging in Sweden along demography, economy, and housing. Next, we trace the origins and development of the Swedish welfare state to consider formal supports (service provision) and informal supports (caregiving and receipt of care). Finally, we direct researchers to additional data resources for understanding aging in Sweden in greater depth. Sweden was one of the first countries to experience rapid population aging. Quality of life for a majority of older Swedes is high. Local control permits a flexible and adaptive set of services and programs, where emphasis is placed on improving the quality and targeting of services that have already reached a plateau as a function of population and expenditures. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. An Excel Add-In for Statistical Process Control Charts

    OpenAIRE

    Buttrey, Samuel E.

    2009-01-01

    Statistical process control (SPC) descibes a widely-used set of approaches used to de- tect shifts in processes in, for example, manufacturing. Among these are \\control charts". Control charts and other SPC techniques have been in use since at least the 1950s, and, because they are comparatively unsophisticated, are often used by management or op- erations personnel without formal statistical training. These personnel will often have experience with the popular spreadsheet prog...

  7. From Sustainability-as-usual to Sustainability Excellence in Local Bioenergy Business

    Directory of Open Access Journals (Sweden)

    Heli Kasurinen

    2017-06-01

    Full Text Available Bioenergy business operators can significantly contribute to the sustainability of bioenergy systems. While research has addressed the maturity of corporate responsibility for sustainability, the maturity levels of bioenergy business have not been determined. The objectives of this research were to characterise the maturity levels of bioenergy corporate responsibility for sustainability and outline an approach by which companies can operate at the most mature sustainability excellence level. Literature, three workshops attended by bioenergy experts and a case study on biobutanol production in Brazil were used to develop the maturity model and approach. The results characterise the profitability, acceptability, and sustainability orientation maturity levels through sustainability questions and methods, and list the components of a systemic, holistic approach. Although the shift of business mindset from sustainability-as-usual to sustainability excellence is challenging, a systemic approach is necessary to broadly identify sustainability questions and a multitude of methods by which they can be answered.

  8. Data acquisition and real-time control using spreadsheets: interfacing Excel with external hardware.

    Science.gov (United States)

    Aliane, Nourdine

    2010-07-01

    Spreadsheets have become a popular computational tool and a powerful platform for performing engineering calculations. Moreover, spreadsheets include a macro language, which permits the inclusion of standard computer code in worksheets, and thereby enable developers to greatly extend spreadsheets' capabilities by designing specific add-ins. This paper describes how to use Excel spreadsheets in conjunction to Visual Basic for Application programming language to perform data acquisition and real-time control. Afterwards, the paper presents two Excel applications with interactive user interfaces developed for laboratory demonstrations and experiments in an introductory course in control. 2010 ISA. Published by Elsevier Ltd. All rights reserved.

  9. The moderating role of leadership in the relationship between management control and business excellence

    NARCIS (Netherlands)

    Doeleman, H.J.; Have, S. ten; Ahaus, K.

    2012-01-01

    This study deals with the moderating role of leadership in the relationship between management control as part of total quality management (TQM) and business excellence in terms of purposive change. Data were collected via a survey filled out by managers working at 44 locations in the Correctional

  10. Quantum metamaterial without local control

    OpenAIRE

    Shvetsov, A.; Satanin, A. M.; Nori, Franco; Savel'ev, S.; Zagoskin, A. M.

    2013-01-01

    A quantum metamaterial can be implemented as a quantum coherent 1D array of qubits placed in a transmission line. The properties of quantum metamaterials are determined by the local quantum state of the system. Here we show that a spatially-periodic quantum state of such a system can be realized without direct control of the constituent qubits, by their interaction with the initializing ("priming") pulses sent through the system in opposite directions. The properties of the resulting quantum ...

  11. Quantum metamaterial without local control

    Science.gov (United States)

    Shvetsov, A.; Satanin, A. M.; Nori, Franco; Savel'ev, S.; Zagoskin, A. M.

    2013-06-01

    A quantum metamaterial can be implemented as a quantum coherent one-dimensional array of qubits placed in a transmission line. The properties of quantum metamaterials are determined by the local quantum state of the system. Here we show that a spatially periodic quantum state of such a system can be realized without direct control of the constituent qubits, by their interaction with the initializing (“priming”) pulses sent through the system in opposite directions. The properties of the resulting quantum photonic crystal are determined by the choice of the priming pulses. This proposal can be readily generalized to other implementations of quantum metamaterials.

  12. Sorsogon State College’s Performance and Management Excellence: Inputs to globally competitive yet locally responsive educational tourism

    Directory of Open Access Journals (Sweden)

    Vivien L. Chua

    2017-11-01

    Full Text Available Educational tourism clearly situates the new role of Sorsogon State College (SSC for world-class education while in support to the locally sustainable tourism development of the province and beyond. This paper was able to assess SSC’s capacities to manage globally competitive and locally responsive educational tourism. A mix method of research was used in examining the SSC’s educational tourism through an inventory of academic performance and quality management excellence for global competitiveness. Results revealed that to attract more educational tourists, SSC is expected to perform effectively and efficiently in a modern research world through the complementation of instruction-research and extension mandates that is contributory to the sustainable development goals. The over-all educational management of SSC is central to leadership including the key aspects of its governance system (personnel behaviour, fulfilment of the societal responsibilities and community support. Further enhancements on the organizational performance of SSC are needed on the following : operations, workforce and clientele support. The College has to strengthen its internationalization policies on the faculty and students inter-country mobility and productivity of its graduates that would address the future educational tourism demands. Further, it has to invest on modern learning resources and support services facilities and equipment to be utilized for instruction, research, extension and administrative workspaces. Thus, closes the gap on job-skills mismatch and the compelling resources requirements of SSC graduates to the local and international markets. With these, an academe-led innovation and transformation project anchored on the SSC’s educational tourism model integrating the Psychology of Tourism to management is introduced.

  13. Local and Integral Control of Workload

    NARCIS (Netherlands)

    M.B.M. de Koster (René); J. Wijngaard (Jacob)

    1989-01-01

    textabstractIn most of the literature on performance analysis of production systems, buffer are assumed to be controlled locally. In automated production systems buffers are not always the result of local physical space restrictions, but may also be software- controlled. Software-controlled buffers

  14. Local Control of Blood Flow

    Science.gov (United States)

    Clifford, Philip S.

    2011-01-01

    Organ blood flow is determined by perfusion pressure and vasomotor tone in the resistance vessels of the organ. Local factors that regulate vasomotor tone include myogenic and metabolic autoregulation, flow-mediated and conducted responses, and vasoactive substances released from red blood cells. The relative importance of each of these factors…

  15. Globalization and localization of Management Control Systems

    DEFF Research Database (Denmark)

    Toldbod, Thomas; Israelsen, Poul

    2014-01-01

    Through an empirical case study this article examines the operation of multiple management control systems as a package in a Danish manufacturing company. The analysis focuses on four different management control systems; cybernetic controls, planning controls, reward controls, and administrative...... controls, through the theoretical lens of globalization, localization, and glocalization. The analysis documents that these different management control systems are affected differently by the processes of globalization and localization, whereby some are universal throughout the organization and others...... have more particular characteristics. Specifically, this study finds that cybernetic controls and administrative controls are designed as global management control systems. Planning controls are glocal systems and reward & compensation controls assume local characteristics. The finding leads...

  16. A Javascript library that uses Windows Script Host (WSH) to analyze prostate motion data fragmented across a multitude of Excel files by the Calypso 4D Localization System.

    Science.gov (United States)

    Vali, Faisal S; Hsi, Alex; Cho, Paul; Parsai, Homayon; Garver, Elizabeth; Garza, Richard

    2008-11-06

    The Calypso 4D Localization System records prostate motion continuously during radiation treatment. It stores the data across thousands of Excel files. We developed Javascript (JScript) libraries for Windows Script Host (WSH) that use ActiveX Data Objects, OLE Automation and SQL to statistically analyze the data and display the results as a comprehensible Excel table. We then leveraged these libraries in other research to perform vector math on data spread across multiple access databases.

  17. A Path toward Safer Heritage Buildings through Excellent Fire Prevention and Control System in Malaysia

    Directory of Open Access Journals (Sweden)

    Md Azree Othuman Mydin

    2014-07-01

    Full Text Available Fire prevention & control system by Fire Rescue Department Malaysia states that protection in the aspects of fire prevention, control and extinguishment for a certain area based on the availability of risks in that area. It is a practice of mitigating the unwanted effects of fires. Besides that, a fire safety system also includes the study of the behaviour, compartmentalisation, suppression and investigation of fire and its related emergencies. In protecting and preserving the historic fabric of the heritage structure there are some major differences which is a challenge for the architect and fire protection engineer in the application of general fire protection principles. The challenge in protecting heritage structure is to maintain their historical fabric while providing a reasonable level of safety for their occupants and contents. In order to avoid harming the building’s historic character, the architect and engineer will need to have the sensitivity and ingenuity approaches to provide fire prevention and protection measures that do not damage the historic fabric of the building. This paper focuses on path toward safer heritage buildings through excellent fire prevention and control system in Malaysia.

  18. Local control approach to ultrafast electron transfer

    Energy Technology Data Exchange (ETDEWEB)

    Vindel-Zandbergen, Patricia [Departamento de Química Física, Universidad Complutense, 28040 Madrid (Spain); Meier, Christoph [Laboratoire Colisions, Agrégats et Reactivité, UMR 5589, IRSAMC, Université Paul Sabatier, 31062 Toulouse (France); Sola, Ignacio R., E-mail: isola@quim.ucm.es [Departamento de Química Física, Universidad Complutense, 28040 Madrid (Spain)

    2016-10-20

    We study ultrafast electron transfer between separated nuclei using local control theory. By imposing electron ionization and electron transport through the continuum, different local control formulations are used to increase the yield of retrapping the electron at the desired nuclei. The control mechanism is based on impulsive de-excitation. Both symmetric and asymmetric nuclear arrangements are analyzed, as well as the role of the nuclear motion.

  19. Radiotherapy and local control in rectal cancer.

    Science.gov (United States)

    Valentini, V; Rosetto, M E; Fares, C; Mantini, G; Salvi, G; Turriziani, A

    1998-01-01

    Recurrence is a stage in the natural history of rectal cancer. Preoperative radiotherapy or postoperative radiochemotherapy lower the rate of recurrence, improving local control. From 1980 to 1997, at the "Divisione di Radioterapia" of the "Università Cattolica del S. Cuore" of Rome 380 patients with rectal cancer of early clinical stage T2-3, candidates for surgery for cure, underwent radiation therapy. 119 patients underwent postoperative radiotherapy (45-50 Gy); 45 patients underwent "sandwich" radiotherapy (45 Gy:27 Gy before and 28 Gy after surgery), of whom 7 were treated with preoperative radiotherapy alone; 145 patients underwent preoperative concomitant radiochemotherapy according to 3 different protocols, radiotherapy (38 Gy) combined with mitomycin C and 5-FU; radiotherapy (50.4 Gy) combined with cisplatin and 5-FU; radiotherapy (45 Gy) combined with 5-FU and folinic acid. 71 patients were treated with preoperative radiotherapy (38 Gy) combined with IORT (10 Gy). Median follow-up was 6 years. Overall local control was 85% at 3 years, 83% at 5 years, 81% at 10 years. The rate of local control at 5 years was: 76% for postoperative radiotherapy, 83% for "sandwich" radiotherapy, 84% for preoperative radiochemotherapy and 93% for preoperative radiotherapy combined with IORT. Local control was shown to be significantly better with preoperative treatment as compared to postoperative treatment (p = 0.02). The incidence of metastases was 35% in the patients with local recurrence and 16% in those with local control. The difference in survival was highly significant in patients with local control as compared to those with local recurrence: at 5 years 87% and 32% respectively. Patients with local control showed a lower incidence of metastasis and a better survival.

  20. Quality Controlled Local Climatological Data (QCLCD) Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Quality Controlled Local Climatological Data (QCLCD) contains summaries from major airport weather stations that include a daily account of temperature extremes,...

  1. Excel simulations

    CERN Document Server

    Verschuuren, Gerard M

    2013-01-01

    Covering a variety of Excel simulations, from gambling to genetics, this introduction is for people interested in modeling future events, without the cost of an expensive textbook. The simulations covered offer a fun alternative to the usual Excel topics and include situations such as roulette, password cracking, sex determination, population growth, and traffic patterns, among many others.

  2. Controlled hydrothermal synthesis of CeO{sub 2} nanospheres and their excellent magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Niu, Xiaofei [Suzhou University, Anhui Key Laboratory of Spintronics and Nanomaterials Research, Suzhou, Anhui (China)

    2017-04-15

    Monodisperse spherical CeO{sub 2} nanostructures with irregular and rough surfaces have successfully been synthesized via a facile hydrothermal technology. XRD, SEM, XPS, Raman scattering, and M-H curves were employed to characterize the samples. The results showed that the spherical CeO{sub 2} nanostructures have a cubic fluorite structure and that there are Ce{sup 3+} ions and oxygen vacancies in the surface of the samples. The M-H curve of CeO{sub 2} nanospheres exhibits excellent room-temperature ferromagnetism (RT-FM), which is likely ascribed to the effects of the Ce{sup 3+} ions and oxygen vacancies. (orig.)

  3. Why Excel?

    Science.gov (United States)

    Barreto, Humberto

    2015-01-01

    This article is not the usual Excel pedagogy fare in that it does not provide an application or example taught via a spreadsheet. Instead, it briefly reviews the history of spreadsheets in the economics classroom and explores the current environment, with an emphasis on modern learning theory. The conclusion is not surprising: spreadsheets improve…

  4. A Path toward Safer Heritage Buildings through Excellent Fire Prevention and Control System in Malaysia

    OpenAIRE

    Md Azree Othuman Mydin; Khaw Yen Yen

    2014-01-01

    Fire prevention & control system by Fire Rescue Department Malaysia states that protection in the aspects of fire prevention, control and extinguishment for a certain area based on the availability of risks in that area. It is a practice of mitigating the unwanted effects of fires. Besides that, a fire safety system also includes the study of the behaviour, compartmentalisation, suppression and investigation of fire and its related emergencies. In protecting and preserving t...

  5. Local Energy Monitoring and Control Analysis

    Science.gov (United States)

    1980-08-28

    windows, walls, insulation) and function of conditions, i.e. temperature, humidity, ventilation , illumination, and electro- mechanical equipment. A...considerations requisite to installingI control devices local to a building’s mechanical system.It further discusses methods for measuring a project’s...Dual Duct High Velocity Systems 14 3.1.6 Variable Volume Air Systems 17 3.1.7 Induction Systems 19 3.1.8 Fan Coils - Unit Ventilators 21 3.1.9 Water

  6. Sourcing Excellence

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi

    2011-01-01

    the competitiveness of manufacturing companies (7). Over the last couple of years, supplier’s development is an evolution in supply chain management and there is a growing interest in generating approaches for meaningful development of suppliers and SDI. This would allow businesses to snatch long-term strategic......Sourcing Excellence is one of the key performance indicators (KPIs) in this world of ever changing sourcing strategies. Manufacturing companies need to access and diagnose the reliability and competencies of existing suppliers in order to coordinate and develop them. This would help in managing....... In essence, this would allow the deployment of both internal and external skills and competencies to determine the new approaches towards organizing, supporting and improving supplier driven innovations (SDI) and supplier relationship management (SRM). This is to achieve operational excellence...

  7. Local control of striatal dopamine release

    Directory of Open Access Journals (Sweden)

    Roger eCachope

    2014-05-01

    Full Text Available The mesolimbic and nigrostriatal dopamine (DA systems play a key role in the physiology of reward seeking, motivation and motor control. Importantly, they are also involved in the pathophysiology of Parkinson’s and Huntington’s disease, schizophrenia and addiction. Control of DA release in the striatum is tightly linked to firing of DA neurons in the ventral tegmental area (VTA and the substantia nigra (SN. However, local influences in the striatum affect release by exerting their action directly on axon terminals. For example, endogenous glutamatergic and cholinergic activity is sufficient to trigger striatal DA release independently of cell body firing. Recent developments involving genetic manipulation, pharmacological selectivity or selective stimulation have allowed for better characterization of these phenomena. Such termino-terminal forms of control of DA release transform considerably our understanding of the mesolimbic and nigrostriatal systems, and have strong implications as potential mechanisms to modify impaired control of DA release in the diseased brain. Here, we review these and related mechanisms and their implications in the physiology of ascending DA systems.

  8. Tracking local control of a parabolic trough collector; Control local de seguimiento cilindro parabolico ACE20

    Energy Technology Data Exchange (ETDEWEB)

    Ajona, J.I.; Alberdi, J.; Gamero, E.; Blanco, J.

    1992-07-01

    In the local control, the sun position related to the trough collector is measured by two photo-resistors. The provided electronic signal is then compared with reference levels in order to get a set of B logical signals which form a byte. This byte and the commands issued by a programmable controller are connected to the inputs of o P.R.O.M. memory which is programmed with the logical equations of the control system. The memory output lines give the control command of the parabolic trough collector motor. (Author)

  9. Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility.

    Science.gov (United States)

    Du, Yingying; Liu, Haoming; Shuang, Jiaqi; Wang, Jianglin; Ma, Jun; Zhang, Shengmin

    2015-11-01

    Fabrication of bulk biomaterials with controlled structures and excellent properties is increasingly important in tissue engineering, but remains a major challenge in the current stage. Herein we used selective laser sintering (SLS) to construct a series of three-dimensional (3D) bone scaffolds with uniform multi-scaled porosity, moderate mechanical properties as well as good biocompatibility. As starting architectural units for SLS, the pure microspheres of polycaprolactone (PCL) and the composite microspheres of PCL and hydroxyapatite (HA) were firstly synthesized via a modified solvent evaporation method, respectively. Our findings showed that the as-prepared microspheres exhibited the uniform size and monodispersity. Moreover, the microsphere-based 3D scaffolds generated by SLS technique showed a multi-scaled porous structure, and adequate mechanical features. Both in vitro and in vivo evaluations further demonstrated that the resultant SLS-derived scaffolds can not only manipulate multiple stem cell behaviors including promoting cell adhesion, supporting cell proliferation and inducing cell differentiation in vitro, but also showed an excellent histocompatibility and induced the vascularization of newly formed tissue in vivo. Consequently, our current study suggests a feasible and effective protocol for fabricating new biomimetic bone biomaterials via SLS technique, also paves a new way for other bulk biomaterials. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Passing excellence

    Science.gov (United States)

    Tsoupikova, Daria

    2007-02-01

    This paper describes the research and development of a virtual reality visualization project "Passing excellence" about the world famous architectural ensemble "Kizhi". The Kizhi Pogost is located on an island in Lake Onega in northern Karelia in Russia. It is an authentic museum of an ancient wood building tradition which presents a unique artistic achievement. This ensemble preserves a concentration of masterpieces of the Russian heritage and is included in the List of Most Endangered Sites of the World Monuments Watch protected by World Heritage List of UNESCO. The project strives to create a unique virtual observation of the dynamics of the architectural changes of the museum area beginning from the 15th Century up to the 21st Century. The visualization is being created to restore the original architecture of Kizhi island based on the detailed photographs, architectural and geometric measurements, textural data, video surveys and resources from the Kizhi State Open-Air Museum archives. The project is being developed using Electro, an application development environment for the tiled display high-resolution graphics visualization system and can be shown on the virtual reality systems such as the GeoWall TM and the C-Wall.

  11. GPS as local geological control and national geodetic control

    Science.gov (United States)

    Cross, P. A.; Sellers, P. C.

    In June 1987 GPS surveys were carried out around six Greek SLR sites. These sites are part of the WEGENER/MEDLAS network in the Eastern Mediterranean region. In a three week campaign six small fiducial networks, typically 5-10 km, were successfully surveyed. Results show that the local geological stability of a SLR site can easily be monitored at the (sub)centimetre level. Since the fiducial networks included Greek national triangulation pillars, GPS also proved to be an efficient tool for tying the zero-order SLR (baseline) network to the national control network.

  12. Towards structural controllability of local-world networks

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Shiwen, E-mail: sunsw80@126.com [Tianjin Key Laboratory of Intelligence Computing and Novel Software Technology, Tianjin University of Technology, Tianjin 300384 (China); Key Laboratory of Computer Vision and System (Tianjin University of Technology), Ministry of Education, Tianjin 300384 (China); Ma, Yilin; Wu, Yafang; Wang, Li; Xia, Chengyi [Tianjin Key Laboratory of Intelligence Computing and Novel Software Technology, Tianjin University of Technology, Tianjin 300384 (China); Key Laboratory of Computer Vision and System (Tianjin University of Technology), Ministry of Education, Tianjin 300384 (China)

    2016-05-20

    Controlling complex networks is of vital importance in science and engineering. Meanwhile, local-world effect is an important ingredient which should be taken into consideration in the complete description of real-world complex systems. In this letter, structural controllability of a class of local-world networks is investigated. Through extensive numerical simulations, firstly, effects of local world size M and network size N on structural controllability are examined. For local-world networks with sparse topological configuration, compared to network size, local-world size can induce stronger influence on controllability, however, for dense networks, controllability is greatly affected by network size and local-world effect can be neglected. Secondly, relationships between controllability and topological properties are analyzed. Lastly, the robustness of local-world networks under targeted attacks regarding structural controllability is discussed. These results can help to deepen the understanding of structural complexity and connectivity patterns of complex systems. - Highlights: • Structural controllability of a class of local-world networks is investigated. • For sparse local-world networks, compared to network size, local-world size can bring stronger influence on controllability. • For dense networks, controllability is greatly affected by network size and the effect of local-world size can be neglected. • Structural controllability against targeted node attacks is discussed.

  13. Searching for excellence

    Science.gov (United States)

    Yager, Robert E.

    Visits to six school districts which were identified by the National Science Teachers Association's Search for Excellence program were made during 1983 by teams of 17 researchers. The reports were analyzed in search for common characteristics that can explain the requirements necessary for excellent science programs. The results indicate that creative ideas, administrative and community involvement, local ownership and pride, and well-developed in-service programs and implementation strategies are vital. Exceptional teachers with boundless energies also seem to exist where exemplary science programs are found.

  14. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle

    Energy Technology Data Exchange (ETDEWEB)

    Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

    2009-10-15

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  15. Pelvis Ewing sarcoma: Local control and survival in the modern era.

    Science.gov (United States)

    Ahmed, Safia K; Robinson, Steven I; Arndt, Carola A S; Petersen, Ivy A; Haddock, Michael G; Rose, Peter S; Issa Laack, Nadia N

    2017-09-01

    Local control for Ewing sarcoma (ES) has improved in modern studies. However, it is unclear if these gains have also been achieved for pelvis tumors. The purpose of this study is to evaluate local control and survival in pelvis ES patients treated in the modern era. All pelvis ES patients diagnosed from 1990 to 2012 and seen at Mayo Clinic were identified. Factors relevant to survival and local control were analyzed. The cohort consisted of 48 patients. Fifty-two percent had metastatic disease at diagnosis. The 5-year overall survival and event-free survival was 73% and 65%, respectively, for localized disease. The 5-year cumulative incidence of local recurrence was 19%, with a 26% incidence for radiation, 13% for surgery, and 0% for surgery + radiation (P = 0.54). All local failures occurred in-field. Sacral involvement by tumor trended toward a higher incidence of local recurrence (hazard ratio 3.06, P = 0.09). Patients treated with definitive radiation doses ≥5,600 cGy had a lower incidence of local recurrence (17% vs. 28%, P = 0.61). Our study demonstrates excellent survival for localized tumors in the modern era. Anatomical localization within the pelvis likely correlates with outcomes. Local control remains problematic, especially for patients treated with definitive radiation. Though statistically not significant, surgery + radiation and definitive radiation dose ≥5,600 cGy were associated with the lowest incidence of local failure, suggesting treatment intensification may improve local control for pelvis ES. © 2017 Wiley Periodicals, Inc.

  16. [Consideration about chemistry, manufacture and control (CMC) key problems in simplified registration of classical traditional Chinese medicine excellent prescriptions].

    Science.gov (United States)

    Wang, Zhi-Min; Liu, Ju-Yan; Liu, Xiao-Qian; Wang, De-Qin; Yan, Li-Hua; Zhu, Jin-Jin; Gao, Hui-Min; Li, Chun; Wang, Jin-Yu; Li, Chu-Yuan; Ni, Qing-Chun; Huang, Ji-Sheng; Lin, Juan

    2017-05-01

    As an outstanding representative of traditional Chinese medicine(TCM) prescriptions accumulated from famous TCM doctors' clinical experiences in past dynasties, classical TCM excellent prescriptions (cTCMeP) are the most valuable part of TCM system. To support the research and development of cTCMeP, a series of regulations and measures were issued to encourage its simplified registration. There is still a long-way to go because many key problems and puzzles about technology, registration and administration in cTCMeP R&D process are not resolved. Based on the analysis of registration and management regulations of botanical drug products in FDA of USA and Japan, and EMA of Europe, the possible key problems and countermeasures in chemistry, manufacture and control (CMC) of simplified registration of cTCMeP were analyzed on the consideration of its actual situation. The method of "reference decoction extract by traditional prescription" (RDETP) was firstly proposed as standard to evaluate the quality and preparation uniformity between the new developing product under simplified registration and traditional original usages of cTCMeP, instead of Standard Decoction method in Japan. "Totality of the evidence" approach, mass balance and bioassay/biological assay of cTCMeP were emphatically suggested to introduce to the quality uniformity evaluation system in the raw drug material, drug substance and final product between the modern product and traditional decoction. Copyright© by the Chinese Pharmaceutical Association.

  17. Coping with Excellence.

    Science.gov (United States)

    Culler, Jonathan

    2002-01-01

    Suggests that when the university devotes itself to "excellence," it substitutes, for a vision of what should be taught, a contentless measure, a bureaucratic concept that extends the range of managerial control without presuming to make judgments about content. Suggests that English departments should try to design sequences of courses that are…

  18. Towards probabilistic synchronisation of local controllers

    Czech Academy of Sciences Publication Activity Database

    Herzallah, R.; Kárný, Miroslav

    2017-01-01

    Roč. 48, č. 3 (2017), s. 604-615 ISSN 0020-7721 R&D Projects: GA ČR GA13-13502S Institutional support: RVO:67985556 Keywords : cooperative control * optimal control * complex systems * stochastic systems * fully probabilistic desing Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 2.285, year: 2016

  19. Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI

    Directory of Open Access Journals (Sweden)

    Marta D. Switlyk

    2014-03-01

    Conclusion: RT provided excellent local tumor control in patients with SM. Most patients benefit from RT even in cases of progressive vertebral fracture. Pain response was not associated with imaging findings and MRI cannot be used to select patients at risk of not responding to RT.

  20. Globalization and Localization of the Management Control System package

    DEFF Research Database (Denmark)

    Toldbod, Thomas; Israelsen, Poul

    2015-01-01

    Through an empirical case study, this article examines the operation of multiple management control systems as a package in a Danish manufacturing company. The analysis focuses on four different management control systems – cybernetic controls, planning controls, reward controls, and administrative...... controls – through the theoretical lens of globalization, localization, and glocalization. Based on a single-case study, the analysis documents that these different management control systems are affected differently by the processes of globalization and localization, some of which are universal throughout...... the organization and others have more particular characteristics. Specifically, this study finds that cybernetic controls and administrative controls are designed as global management control systems. Planning controls and reward and compensation controls are glocal systems. The finding leads to the conclusion...

  1. High-Stakes Examination Preparation that Controls Teaching: Chinese Prospective Teachers' Conceptions of Excellent Teaching and Assessment

    Science.gov (United States)

    Chen, Junjun; Brown, Gavin T. L.

    2013-01-01

    How prospective teachers conceive of teaching excellence and assessment purposes probably influences how teaching and assessment practices are implemented in the future. This study evaluated, in four "normal universities" in the People's Republic of China, 765 prospective teachers' responses to two self-report instruments regarding the…

  2. Local labor unions' positions on worksite tobacco control.

    Science.gov (United States)

    Sorensen, G; Stoddard, A M; Youngstrom, R; Emmons, K; Barbeau, E; Khorasanizadeh, F; Levenstein, C

    2000-01-01

    OBJECTIVES: This report describes local unions' positions on tobacco control initiatives and factors related to these positions. METHODS: A national random sample of local union leaders was surveyed by telephone. RESULTS: Forty-eight percent of local unions supported worksite smoking bans or restrictions, and only 8% opposed both a ban and a restriction. CONCLUSIONS: Support for tobacco control initiatives among local unions was higher than might be expected on the basis of previous evidence. Engaging unions in smoking policy formation is likely to contribute to the larger public health goal of reducing smoking and exposure to second-hand smoke among workers. PMID:10754979

  3. Cancer of the anal canal and local control.

    Science.gov (United States)

    Valentini, V; Mantello, G; Luzi, S; Macchia, G; Manfrida, S; Smaniotto, D

    1998-01-01

    Concomitant radiochemotherapy is the standard treatment of squamous cell carcinoma of the anal canal. It can afford a high local control rate though the same impact has not been observed on survival. A few reports have concerned the impact of local control on distant metastases and survival. From 1988 to 1998 at the "Divisione di Radioterapia" of the "Università Cattolica del S. Cuore" of Rome 30 patients with squamous cell carcinoma of the anal canal were treated for cure. Treatment consisted of two cycles of radiotherapy (23.4 Gy) with a 4-5 week split in each cycle. 5FU (100 mg/sqm/24 h) was administered in continuous infusion for the first 4 days of therapy; mitomycin C (10 mg/sqm bolus) was administered on day 1, 4-6 weeks after the end of cycle 2 of concomitant radiochemotherapy, patients received a boost of interstitial brachytherapy. Local control on T of all patients was 84% at 5 years. Six patients showed locoregional recurrence: 3 recurrences on T and 4 disease progressions in locoregional lymph nodes. 3 of 6 patients underwent salvage surgery. The initial extent of the disease, the patient's age and brachytherapy boost did not have a statistically significant influence on local control. Two of the 30 patients showed liver metastases, and at their appearance, one patient was free of local disease while the other showed locoregional progression after Miles' operation for salvage. The metastasis-free interval was not significantly influenced by local control, although at 5 years, 96% of patients with local control of T were free of metastases vs 75% of those with recurrence on T (p = 0.22). Overall actuarial survival at 5 years was 75%. The behavior of survival in our experience seemed to be significantly influenced by local control: in the group with local control, 5-year survival was 85% vs 40% of patients with local recurrence (p = 0.01).

  4. Excelling with Excel: Advanced Excel Functions for Collection Analysis

    OpenAIRE

    Pan, Denise; Wiersma, Gabrielle

    2014-01-01

    Microsoft Excel offers useful features and formulas that potentially allow acquisitions and collection development librarians to work smarter, not harder. Using journal cancellations as a workplace scenario, the presenters will provide attendees with ideas on how to organize data and complete basic calculations with Excel. The presenters provide examples on how to use several advanced Excel functions including PivotTables, VLOOKUP, and select formulas. They describe the steps for importing an...

  5. Fine Control of Local Whitespace in Placement

    Directory of Open Access Journals (Sweden)

    Jarrod A. Roy

    2008-01-01

    Full Text Available In modern design methodologies, a large fraction of chip area during placement is left unused by standard cells and allocated as “whitespace.” This is done for a variety of reasons including the need for subsequent buffer insertion, as a means to ensure routability, signal integrity, and low coupling capacitance between wires, and to improve yield through DFM optimizations. To this end, layout constraints often require a certain minimum fraction of whitespace in each region of the chip. Our work introduces several techniques for allocation of whitespace in global, detail, and incremental placement. Our experiments show how to efficiently improve wirelength by reallocating whitespace in legal placements at the large scale. Additionally, for the first time in the literature, we empirically demonstrate high-precision control of whitespace in designs with macros and obstacles. Our techniques consistently improve the quality of whitespace allocation of top-down as well as analytical placement methods and achieve low penalties on designs from the ISPD 2006 placement contest with minimal interconnect increase.

  6. QUESTION OF IMPROVEMENT OF BUDGET CONTROL AT THE LOCAL LEVEL

    Directory of Open Access Journals (Sweden)

    Oleg Vatslavskyi

    2016-11-01

    Full Text Available The aim is to analyse the current practice of budgetary control to develop its areas of improvement at the local level. The subject of the research is theoretical and methodological principles of functioning of budgetary control at the local level. The methodological basis of the study comprises research approaches, general theoretical principles of scientific knowledge, system of methods and techniques. The paper clarifies the nature of budgetary control at the local level. The main bodies that implement budget control, namely the State Audit Office, the Accounting Chamber, the State Treasury, the State Fiscal Service, financial and management departments are singled out. It is found that the leading part among all of the special budgetary control bodies in the rational and efficient use of local financial resources is performed by the State Audit Office. Analysis of the State Audit Office in three regions of Ukraine for the period 2013-2015 has been carried out. We distinguish two main types of violations that the State Audit Service reveals during its work at the local level: 1 shortfall in the financial resources of public enterprises, institutions and organizations; 2 violations that lead to illegal, non-target costs and shortages. It is proved that the efficiency of budgetary control is low. The paper states basic problems of budget control at the local level, namely, low income funds and reimbursements from violations revealed by regulatory agencies; insufficient work with the public to explain the problems of budget control and eliminate violations in the public sector; lack of a consolidated legal act, which would have regulated all the major components of budgetary control; insufficient use of controlling and auditing methods aimed at determining the effectiveness of budget funds; low preventive function on the part of budget control bodies. We offer ways to improve budget control at the local level through: standardization system of

  7. A mobile console for local access to accelerator control systems.

    CERN Multimedia

    1981-01-01

    Microprocessors were installed as auxiliary crate controllers (ACCs) in the CAMAC interface of control systems for various accelerators. The same ACC was also at the hearth of a stand-alone system in the form of a mobile console. This was also used for local access to the control systems for tests and development work (Annual Report 1981, p. 80, Fig. 10).

  8. Writing Excel Macros with VBA

    CERN Document Server

    Roman, Steven

    2008-01-01

    To achieve the maximum control and flexibility from Microsoft® Excel often requires careful custom programming using the VBA (Visual Basic for Applications) language. Writing Excel Macros with VBA, 2nd Edition offers a solid introduction to writing VBA macros and programs, and will show you how to get more power at the programming level: focusing on programming languages, the Visual Basic Editor, handling code, and the Excel object model.

  9. Further progress in control of localized nonlinear waves

    Science.gov (United States)

    Porubov, A. V.; Antonov, I. D.; Fradkov, A. L.

    2017-12-01

    Previously found mechanical system is studied which consists of the nonlinearly elastic layer subjected to external loading. The last is assumed to be a distributive control which causes in particular, localization of longitudinal nonlinear strain waves. Various types of localized nonlinear waves are achieved due to a suitable choice of the external loading. Wave profiles arising at variations around this optimal choice of the control are studied.

  10. Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma.

    Science.gov (United States)

    Casey, Dana L; Kushner, Brian H; Cheung, Nai-Kong V; Modak, Shakeel; LaQuaglia, Michael P; Wolden, Suzanne L

    2016-10-01

    To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma. After receiving dose-intensive chemotherapy and gross total resection (GTR), 246 patients (aged 1.2-17.9 years, median 4.0 years) with high-risk neuroblastoma underwent RT to the primary site at Memorial Sloan Kettering from 2000 to 2014. Radiation therapy consisted of 21 Gy in twice-daily fractions of 1.5 Gy each. Local failure (LF) was correlated with biologic prognostic factors and clinical findings at the time of diagnosis and start of RT. Median follow-up of surviving patients was 6.4 years. Cumulative incidence of LF was 7.1% at 2 years after RT and 9.8% at 5 years after RT. The isolated LF rate was 3.0%. Eighty-six percent of all local failures were within the RT field. Local control was worse in patients who required more than 1 surgical resection to achieve GTR (22.4% vs 8.3%, P=.01). There was also a trend toward inferior local control with MYCN-amplified tumors or serum lactate dehydrogenase ≥1500 U/L (P=.09 and P=.06, respectively). After intensive chemotherapy and maximal surgical debulking, hyperfractionated RT with 21 Gy in high-risk neuroblastoma results in excellent local control. Given the young patient age, concern for late effects, and local control >90%, dose reduction may be appropriate for patients without MYCN amplification who achieve GTR. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Dana L. [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Kushner, Brian H.; Cheung, Nai-Kong V.; Modak, Shakeel [Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York (United States); LaQuaglia, Michael P. [Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne L., E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States)

    2016-10-01

    Purpose: To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma. Methods and Materials: After receiving dose-intensive chemotherapy and gross total resection (GTR), 246 patients (aged 1.2-17.9 years, median 4.0 years) with high-risk neuroblastoma underwent RT to the primary site at Memorial Sloan Kettering from 2000 to 2014. Radiation therapy consisted of 21 Gy in twice-daily fractions of 1.5 Gy each. Local failure (LF) was correlated with biologic prognostic factors and clinical findings at the time of diagnosis and start of RT. Results: Median follow-up of surviving patients was 6.4 years. Cumulative incidence of LF was 7.1% at 2 years after RT and 9.8% at 5 years after RT. The isolated LF rate was 3.0%. Eighty-six percent of all local failures were within the RT field. Local control was worse in patients who required more than 1 surgical resection to achieve GTR (22.4% vs 8.3%, P=.01). There was also a trend toward inferior local control with MYCN-amplified tumors or serum lactate dehydrogenase ≥1500 U/L (P=.09 and P=.06, respectively). Conclusion: After intensive chemotherapy and maximal surgical debulking, hyperfractionated RT with 21 Gy in high-risk neuroblastoma results in excellent local control. Given the young patient age, concern for late effects, and local control >90%, dose reduction may be appropriate for patients without MYCN amplification who achieve GTR.

  12. Excel Initiative: Excellence in Youth Programming

    Directory of Open Access Journals (Sweden)

    Lynne M. Borden

    2015-06-01

    Full Text Available The Excellence in Youth Programming (Excel Initiative strives to support youth programs in delivering high quality programs. The backbone of Excel is the Youth Development Observational Tool (YDOT which allows for the virtual assessment of program staff who work with children and youth ages 9-18 years. The YDOT also allows Excel to provide structured feedback to programs. Excel has several unique features, including a virtual platform and a focus on the relationships between adults and youth participating in after-school programs. Offering structured assessment and interaction online eliminates expenses, provides convenient access for programs around the globe, and allows for unobtrusive assessment of worker-youth interactions. Excel is also integrated into a broader network of resources, tools, and research for those working with children and youth ages 9-18.

  13. Building the evaluation capacity of California's local tobacco control programs.

    Science.gov (United States)

    Treiber, Jeanette; Cassady, Diana; Kipke, Robin; Kwon, Nicole; Satterlund, Travis

    2011-11-01

    Successful evaluation capacity building requires a dynamic balance between responding to local agency needs and ensuring that local staff have appropriate skills to conduct rigorous evaluations. In 2004, the California Tobacco Control Program established the Tobacco Control Evaluation Center (TCEC), based at a public research university, to provide evaluation technical assistance to approximately 100 local agencies implementing tobacco control programs. TCEC has been responsive to local needs, for instance, by answering 512 technical assistance requests in the first 5 years of operation and by tailoring training according to needs assessment results. About 50% of the technical assistance requests were for new data collection instruments (n = 255). TCEC has sought proactively to improve local evaluation skills, most recently in a data analysis and report writing skill building campaign that included a webinar, newsletter, and seven regional training meetings. Preliminary analysis suggests a 20% improvement in scores for the local final evaluation reports as a result of this campaign. It is concluded that evaluation technical assistance can be provided effectively by a university as long as the local context is kept in mind, and a balance of responsive and proactive technical assistance is provided.

  14. Progress in sub-femtosecond control of electron localization in ...

    Indian Academy of Sciences (India)

    2014-01-04

    Jan 4, 2014 ... Recent advances in controlled generation of intense, ultrashort laser pulses in the femtosecond and attosecond time-scales have pushed new avenues of research in the coherent control of ... We discuss the origin of the idea and various mechanisms to achieve electron localization in small molecules.

  15. Excel 2010 for dummies

    CERN Document Server

    Harvey, Greg

    2010-01-01

    The bestselling Excel book on the market, updated for Excel 2010 As the world's leading spreadsheet application, Excel has a huge user base. The release of Office 2010 brings major changes to Excel, so Excel For Dummies comes to the rescue once more! In the friendly and non-threatening For Dummies style, this popular guide shows beginners how to get up and running with Excel and helps more experienced users get comfortable with new features.Excel is the number one spreadsheet application worldwide, and Excel For Dummies is the number one guide to using i

  16. Controlled release for local delivery of drugs: barriers and models.

    Science.gov (United States)

    Weiser, Jennifer R; Saltzman, W Mark

    2014-09-28

    Controlled release systems are an effective means for local drug delivery. In local drug delivery, the major goal is to supply therapeutic levels of a drug agent at a physical site in the body for a prolonged period. A second goal is to reduce systemic toxicities, by avoiding the delivery of agents to non-target tissues remote from the site. Understanding the dynamics of drug transport in the vicinity of a local drug delivery device is helpful in achieving both of these goals. Here, we provide an overview of controlled release systems for local delivery and we review mathematical models of drug transport in tissue, which describe the local penetration of drugs into tissue and illustrate the factors - such as diffusion, convection, and elimination - that control drug dispersion and its ultimate fate. This review highlights the important role of controlled release science in development of reliable methods for local delivery, as well as the barriers to accomplishing effective delivery in the brain, blood vessels, mucosal epithelia, and the skin. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Excellent Teachers' Perspectives on Excellent Teaching

    Science.gov (United States)

    Keeley, Jared W.; Ismail, Emad; Buskist, William

    2016-01-01

    Studies of master teaching have investigated a set of qualities that define excellent teaching. However, few studies have investigated master teachers' perspectives on excellent teaching and how it may differ from other faculty or students. The current study investigated award-winning teachers' (N = 50) ratings of the 28 qualities on the teacher…

  18. Controlled delivery of zoledronate improved bone formation locally in vivo.

    Directory of Open Access Journals (Sweden)

    Wenlong Gou

    Full Text Available Bisphosphonates (BPs have been widely used in clinical treatment of bone diseases with increased bone resorption because of their strong affinity for bone and their inhibition of bone resorption. Recently, there has been growing interest in their improvement of bone formation. However, the effect of local controlled delivery of BPs is unclear. We used polylactide acid-glycolic acid copolymer (PLGA as a drug carrier to deliver various doses of the bisphosphonate zoledronate (Zol into the distal femur of 8-week-old Sprague-Dawley rats. After 6 weeks, samples were harvested and analyzed by micro-CT and histology. The average bone mineral density and mineralized bone volume fraction were higher with medium- and high-dose PLGA-Zol (30 and 300 µg Zol, respectively than control and low-dose Zol (3 µg PLGA-Zol; p<0.05. Local controlled delivery of Zol decreased the numbers of osteoclast and increased the numbers of osteoblast. Moreover, local controlled delivery of medium- and high-dose Zol accelerated the expression of bone-formation markers. PLGA used as a drug carrier for controlled delivery of Zol may promote local bone formation.

  19. Controllable fabrication of Bi2O3/TiO2 heterojunction with excellent visible-light responsive photocatalytic performance

    Science.gov (United States)

    Huang, Yunfang; Wei, Yuelin; Wang, Jing; Luo, Dan; Fan, Leqing; Wu, Jihuai

    2017-11-01

    Three-dimensional Bi2O3/TiO2 hierarchical composites have been successfully prepared by a two-step hydrothermal method and subsequent calcination. The samples were characterized using XRD, SEM, TEM, EDS, BET and DRS. The measurement results signified that heterojunctions of various morphologies β-Bi2O3 growing on the three-dimensional hierarchical anatase TiO2 nanorods arrays on FTO glass were apparently formed. The morphology of Bi2O3 changed from three-dimension flower-like microstructures to the sphere-like nanoparticles as the Li(OH) dosage increased. The photocatalytic results showed that all samples exhibited much higher photocatalytic activities than that of pure Bi2O3 and TiO2 (P25) in photocatalytic degradation of methyl blue (MB) under visible-light irradiation. Whereas BTL4 sample exhibited the highest photoactivity with increasing the dosage of Li(OH) to 2 mmol. Furthermore, the absorption edge of the Bi2O3/TiO2 series composites displayed a broad-spectrum photoabsorption from UV to visible-light compared with the individual component. The as-synthesized Bi2O3/TiO2 composites possessed excellent photocatalytic activity and outstanding recyclability. The enhanced photocatalytic efficiency was mainly attributed to the Bi2O3/TiO2p-n heterojunctions and hierarchical nanostructure. The recombination of photogenerated electron-hole pairs was efficiently suppressed by the Bi2O3/TiO2p-n heterojunctions.

  20. Robust controller for synchronous generator with local load via VSC

    Energy Technology Data Exchange (ETDEWEB)

    Cabrera-Vazquez, J. [Universidad de Guadalajara, Centro Universitario de Ciencias Exactas e Ingenierias, Departamento de Electronica, Av. Revolucion No. 1500, Modulo ' ' O' ' , Apdo. Postal 44840, Guadalajara Jalisco (Mexico); Loukianov, Alexander G.; Canedo, Jose M. [Centro de Investigacion y de Estudios Avanzados del IPN, Apdo. Postal 31-438, Plaza La Luna, C. P. 44550, Guadalajara, Jalisco (Mexico); Utkin, Vadim I. [Department of Electrical Engineering, The Ohio-State University, Columbus, OH 43210-1272 (United States)

    2007-05-15

    The objective of this paper is to design a nonlinear observer-based excitation controller for power system comprising a single synchronous generator connected to an infinite bus with local load. The controller proposed is based on the using first singular perturbation systems concepts and then Sliding Mode Control technique combining with Block Control Principle. To reduce ''chattering'' a nonlinear observer with estimation of the mechanical torque and rotor fluxes is designed. This combined approach enables to compensate the inherent nonlinearities of the generator and to reject external disturbances. (author)

  1. Dynamic subcellular localization of a respiratory complex controls bacterial respiration.

    Science.gov (United States)

    Alberge, François; Espinosa, Leon; Seduk, Farida; Sylvi, Léa; Toci, René; Walburger, Anne; Magalon, Axel

    2015-06-16

    Respiration, an essential process for most organisms, has to optimally respond to changes in the metabolic demand or the environmental conditions. The branched character of their respiratory chains allows bacteria to do so by providing a great metabolic and regulatory flexibility. Here, we show that the native localization of the nitrate reductase, a major respiratory complex under anaerobiosis in Escherichia coli, is submitted to tight spatiotemporal regulation in response to metabolic conditions via a mechanism using the transmembrane proton gradient as a cue for polar localization. These dynamics are critical for controlling the activity of nitrate reductase, as the formation of polar assemblies potentiates the electron flux through the complex. Thus, dynamic subcellular localization emerges as a critical factor in the control of respiration in bacteria.

  2. Progress in sub-femtosecond control of electron localization in ...

    Indian Academy of Sciences (India)

    2014-01-04

    Jan 4, 2014 ... Abstract. Recent advances in controlled generation of intense, ultrashort laser pulses in the ... We discuss the origin of the idea and various ..... generation. 2.3 Electron localization using a combination of many-cycle IR pulse and an attosecond pulse train. Unlike both the above techniques which required ...

  3. Direct Manufacture of Components with Local Control of Composition

    National Research Council Canada - National Science Library

    Sachs, Emanuel

    2005-01-01

    ...; gradient index lenses (GRIN) and metallic components with local composition control. These two classes of application are complimentary in that the GRIN lenses were made of glasses and were fabricated from extremely fine powders handled in a slurry form while the metallic components were fabricated from larger powders that can be dry processed.

  4. Analysis of pan-African Centres of excellence in health innovation highlights opportunities and challenges for local innovation and financing in the continent

    Directory of Open Access Journals (Sweden)

    Nwaka Solomon

    2012-07-01

    Full Text Available Abstract A pool of 38 pan-African Centres of Excellence (CoEs in health innovation has been selected and recognized by the African Network for Drugs and Diagnostics Innovation (ANDI, through a competitive criteria based process. The process identified a number of opportunities and challenges for health R&D and innovation in the continent: i it provides a direct evidence for the existence of innovation capability that can be leveraged to fill specific gaps in the continent; ii it revealed a research and financing pattern that is largely fragmented and uncoordinated, and iii it highlights the most frequent funders of health research in the continent. The CoEs are envisioned as an innovative network of public and private institutions with a critical mass of expertise and resources to support projects and a variety of activities for capacity building and scientific exchange, including hosting fellows, trainees, scientists on sabbaticals and exchange with other African and non-African institutions.

  5. Locally optimal symplectic control of multimode Gaussian states

    Science.gov (United States)

    Shackerley-Bennett, Uther; Carlini, Alberto; Giovannetti, Vittorio; Serafini, Alessio

    2017-12-01

    The relaxation of a system to a steady state is a central point of interest in many attempts to advance control over the quantum world. In this paper, we consider control through instantaneous Gaussian unitary operations on the ubiquitous lossy channel, and find locally optimal conditions for the cooling and heating of a multimode Gaussian state subject to losses and possibly thermal noise. This is done by isolating the parameters that encode entropy and temperature and by deriving an equation for their evolution. This equation is in such a form that it grants clear insight into how relaxation may be helped by instantaneous quantum control. It is thus shown that squeezing is a crucial element in optimising the rate of change of entropic properties under these channels. Exact relaxation times for heating and cooling are derived, up to an arbitrarily small distance from the fixed point of the lossy channel with locally optimal strategies.

  6. Individual pitch control of wind turbines using local inflow measurements

    DEFF Research Database (Denmark)

    Thomsen, Sven Creutz; Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2008-01-01

    This paper describes a model based control approach for individually adjusting the pitch of wind turbine blades and thereby attenuating the effect of asymmetric wind loads. It is assumed that measurements of local inflow along each blade are available. This effectively provides an estimate...... of the load distribution along the blades. The load estimates are used in a predictive setup where inflow measured by one blade is used as basis for calculating future loads for the other blades. Simulations with a full stochastic wind field illustrate the effectiveness of the individual pitch controller...... as compared to controlling the pitch collectively....

  7. Local, Controlled Delivery of Local Anesthetics In Vivo from Polymer - Xerogel Composites.

    Science.gov (United States)

    Qu, Haibo; Costache, Marius C; Inan, Saadet; Cowan, Alan; Devore, David; Ducheyne, Paul

    2016-03-01

    Polymer-xerogel composite materials have been introduced to better optimize local anesthetics release kinetics for the pain management. In a previous study, it was shown that by adjusting various compositional and nano-structural properties of both inorganic xerogels and polymers, zero-order release kinetics over 7 days can be achieved in vitro. In this study, in vitro release properties are confirmed in vivo using a model that tests for actual functionality of the released local anesthetics. Composite materials made with tyrosine-polyethylene glycol(PEG)-derived poly(ether carbonate) copolymers and silica-based sol-gel (xerogel) were synthesized. The in vivo release from the composite controlled release materials was demonstrated by local anesthetics delivery in a rat incisional pain model. The tactile allodynia resulting from incision was significantly attenuated in rats receiving drug-containing composites compared with the control and sham groups for the duration during which natural healing had not yet taken place. The concentration of drug (bupivacaine) in blood is dose dependent and maintained stable up to 120 h post-surgery, the longest time point measured. These in vivo studies show that polymer-xerogel composite materials with controlled release properties represent a promising class of controlled release materials for pain management.

  8. Uniform control of local times of spectrally positive stable processes

    OpenAIRE

    Forman, Noah; Pal, Soumik; Rizzolo, Douglas; Winkel, Matthias

    2016-01-01

    We establish two results about local times of spectrally positive stable processes. The first is a general approximation result, uniform in space and on compact time intervals, in a model where each jump of the stable process may be marked by a random path. The second gives moment control on the H\\"older constant of the local times, uniformly across a compact spatial interval and in certain random time intervals. For the latter, we introduce the notion of a L\\'evy process restricted to a comp...

  9. Ciudadania, el poder local e controle do Estado

    Directory of Open Access Journals (Sweden)

    Angela Moulin Simões Penalva Santos

    2004-01-01

    Full Text Available Brazilian society is experiencing a population expansion within the context of decentralisation of public policies, from the central government to local institutions. Following this line of thought, in this article we analyse the public expenses in the Brazilian Federation in the period 1996-1998 in order to identify the institutions that have assumed the financial right of the citizens, as well as to estimate if there has been a transfer of responsibilities among federal institutions. The success of this process is related to the integrated performance of the external control from the public administration. In that sense, we also study the control exercised by Parliaments, Administrative Courts, Public Prosecution Offices and the Judicial Power beyond social control, taking into consideration their improvement and highlighting the control of the Public Prosecution Office as well as the control exercised by the popular councils.

  10. Active vibroacoustic control with multiple local feedback loops.

    Science.gov (United States)

    Elliott, Stephen J; Gardonio, Paolo; Sors, Thomas C; Brennan, Michael J

    2002-02-01

    When multiple actuators and sensors are used to control the vibration of a panel, or its sound radiation, they are usually positioned so that they couple into specific modes and are all connected together with a centralized control system. This paper investigates the physical effects of having a regular array of actuator and sensor pairs that are connected only by local feedback loops. An array of 4 x 4 force actuators and velocity sensors is first simulated, for which such a decentralized controller can be shown to be unconditionally stable. Significant reductions in both the kinetic energy of the panel and in its radiated sound power can be obtained for an optimal value of feedback gain, although higher values of feedback gain can induce extra resonances in the system and degrade the performance. A more practical transducer pair, consisting of a piezoelectric actuator and velocity sensor, is also investigated and the simulations suggest that a decentralized controller with this arrangement is also stable over a wide range of feedback gains. The resulting reductions in kinetic energy and sound power are not as great as with the force actuators, due to the extra resonances being more prominent and at lower frequencies, but are still worthwhile. This suggests that an array of independent modular systems, each of which included an actuator, a sensor, and a local feedback control loop, could be a simple and robust method of controlling broadband sound transmission when integrated into a panel.

  11. Master VISUALLY Excel 2010

    CERN Document Server

    Marmel, Elaine

    2010-01-01

    The complete visual reference on Excel basics. Aimed at visual learners who are seeking an all-in-one reference that provides in-depth coveage of Excel from a visual viewpoint, this resource delves into all the newest features of Excel 2010. You'll explore Excel with helpful step-by-step instructions that show you, rather than tell you, how to navigate Excel, work with PivotTables and PivotCharts, use macros to streamline work, and collaborate with other users in one document.: This two-color guide features screen shots with specific, numbered instructions so you can learn the actions you need

  12. Excel Dashboards & Reports

    CERN Document Server

    Alexander, Michael

    2010-01-01

    The go to resource for how to use Excel dashboards and reports to better conceptualize data. Many Excel books do an adequate job of discussing the individual functions and tools that can be used to create an "Excel Report." What they don't offer is the most effective ways to present and report data. Offering a comprehensive review of a wide array of technical and analytical concepts, Excel Reports and Dashboards helps Excel users go from reporting data with simple tables full of dull numbers, to presenting key information through the use of high-impact, meaningful reports and dashboards that w

  13. Excel 2010 Made Simple

    CERN Document Server

    Katz, Abbott

    2011-01-01

    Get the most out of Excel 2010 with Excel 2010 Made Simple - learn the key features, understand what's new, and utilize dozens of time-saving tips and tricks to get your job done. Over 500 screen visuals and clear-cut instructions guide you through the features of Excel 2010, from formulas and charts to navigating around a worksheet and understanding Visual Basic for Applications (VBA) and macros. Excel 2010 Made Simple takes a practical and highly effective approach to using Excel 2010, showing you the best way to complete your most common spreadsheet tasks. You'll learn how to input, format,

  14. Excel 2013 formulas

    CERN Document Server

    Walkenbach, John

    2013-01-01

    Maximize the power of Excel 2013 formulas with this must-have Excel reference John Walkenbach, known as ""Mr. Spreadsheet,"" is a master at deciphering complex technical topics and Excel formulas are no exception. This fully updated book delivers more than 800 pages of Excel 2013 tips, tricks, and techniques for creating formulas that calculate, developing custom worksheet functions with VBA, debugging formulas, and much more. Demonstrates how to use all the latest features in Excel 2013 Shows how to create financial formulas and tap into the power of array formulas

  15. Excel 2013 simplified

    CERN Document Server

    McFedries, Paul

    2013-01-01

    A friendly, visual approach to learning the basics of Excel 2013 As the world's leading spreadsheet program, Excel is a spreadsheet and data analysis tool that is part of the Microsoft Office suite. The new Excel 2013 includes new features and functionalities that require users of older versions to re-learn the application. However, whether you're switching from an earlier version or learning Excel for the first time, this easy-to-follow visual guide gets you going with Excel 2013 quickly and easily. Numbered steps as well as full-color screen shots, concise information, and helpfu

  16. Bandgap control with local and interconnected LC piezoelectric shunts

    Science.gov (United States)

    Flores Parra, Edgar A.; Bergamini, Andrea; Lossouarn, Boris; Van Damme, Bart; Cenedese, Mattia; Ermanni, Paolo

    2017-09-01

    This paper reports on the control of longitudinal wave propagation, in the kHz frequency range, using local and interconnected LC (inductance-capacitance) shunts distributed periodically along a rod. The LC shunts are connected to piezoelectric inserts and tuned to engender narrow or broad-band pass-bands in the forbidden band frequency range. The Bragg-scattering bandgaps are the result of the periodic mechanical mismatch between PMMA (polymethyl-methacrylate) of the rod and PZT (lead-zirconate-titanate). The narrow pass-bands correspond to the local configuration, where an equivalence between the mechanical impedance of the PMMA and PZT occurs around the shunt resonance frequency. Conversely, the interconnected shunts give a way to an electrical medium through which energy can propagate parallel to its mechanical counterpart, leading to broad pass-bands. This paper presents analytical models for calculating the dispersion and displacements of the 1D medium with interconnected LC shunts. An analytical formulation is also introduced to expediently identify the location of bandgaps and pass-bands in the medium comprised of local LC shunts. Moreover, analytical investigations are carried out to elucidate different physical phenomena giving rise to these pass-bands. The findings are experimentally validated using a finite periodic rod. The ability to tune the dispersion properties of the medium to control the width or depth of the bandgap, by utilizing local or interconnected shunts, offers a new and powerful application for piezoelectric shunts.

  17. Controlling Androgen receptor nuclear localization by dendrimer conjugates

    Science.gov (United States)

    Wang, Haoyu

    Androgen Receptor (AR) antagonists, such as bicalutamide and flutamide have been used widely in the treatment of prostate cancer. Although initial treatment is effective, prostate cancer cells often acquire antiandrogen resistance with prolonged treatment. AR over-expression and AR mutations contribute to the development of antiandrogen resistant cancer. Second generation antiandrogens such as enzalutamide are more effective and show reduced AR nuclear localization. In this study, derivatives of PAN52, a small molecule antiandrogen previously developed in our lab, were conjugated to the surface of generation 4 and generation 6 PAMAM dendrimers to obtain antiandrogen PAMAM dendrimer conjugates (APDC). APDCs readily enter cells and associate with AR in the cytoplasm. Due to their large size and positive charge, they can not enter the nucleus, thus retaining AR in the cytoplasm. In addition, APDCs are effective in decreasing AR mediated transcription and cell proliferation. APDC is the first AR antagonists that inhibit DHT-induced nuclear localization of AR. By inhibiting AR nuclear localization, APDC represents a new class of antiandrogens that offer an alternative approach to addressing antiandrogen-resistant prostate cancer. Lysine post-translational modification of AR Nuclear Localization Sequence (NLS) has great impact on AR cellular localization. It is of interest to understand which modifications modulate AR translocation into the nucleus. In this study, we prepared dendrimer-based acetyltransferase mimetic (DATM), DATM is able to catalytically acetylate AR in CWR22Rv1 cells, which will be a useful tool for studying AR modification effect on AR cellular localization. Derivatives of DATM, which transfer other chemical groups to AR, can be prepared similarly, and with more dendrimer based AR modification tools prepared in future, we will be able to understand and control AR cellular localization through AR modification.

  18. PRMT1-mediated arginine methylation controls ATXN2L localization

    Energy Technology Data Exchange (ETDEWEB)

    Kaehler, Christian; Guenther, Anika; Uhlich, Anja; Krobitsch, Sylvia, E-mail: krobitsc@molgen.mpg.de

    2015-05-15

    Arginine methylation is a posttranslational modification that is of importance in diverse cellular processes. Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2. Here, we investigated the methylation state of ATXN2L and its significance for ATXN2L localization. We first confirmed that ATXN2L is asymmetrically dimethylated in vivo, and observed that the nuclear localization of ATXN2L is altered under methylation inhibition. We further discovered that ATXN2L associates with the protein arginine-N-methyltransferase 1 (PRMT1). Finally, we showed that neither mutation of the arginine–glycine-rich motifs of ATXN2L nor methylation inhibition alters ATXN2L localization to stress granules, suggesting that methylation of ATXN2L is probably not mandatory. - Highlights: • ATXN2L is asymmetrically dimethylated in vivo. • ATXN2L interacts with PRMT1 under normal and stress conditions. • PRMT1-mediated dimethylation of ATXN2L controls its nuclear localization. • ATXN2L localization to stress granules appears independent of its methylation state.

  19. Clinical excellence in cardiology.

    Science.gov (United States)

    Ziegelstein, Roy C

    2011-08-15

    A recent study identified 7 domains of clinical excellence on the basis of interviews with "clinically excellent" physicians at academic institutions in the United States: (1) communication and interpersonal skills, (2) professionalism and humanism, (3) diagnostic acumen, (4) skillful negotiation of the health care system, (5) knowledge, (6) taking a scholarly approach to clinical practice, and (7) having passion for clinical medicine. What constitutes clinical excellence in cardiology has not previously been defined. The author discusses clinical excellence in cardiology using the framework of these 7 domains and also considers the additional domain of clinical experience. Specific aspects of the domains of clinical excellence that are of greatest relevance to cardiology are highlighted. In conclusion, this discussion characterizes what constitutes clinical excellence in cardiology and should stimulate additional discussion of the topic and an examination of how the domains of clinical excellence in cardiology are related to specific patient outcomes. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. French local agencies of energy control; Agences locales francaise de maitrise de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    In the framework of the SAVE program, the European Commission brings financial assistance to the creation of local or regional agencies of energy control in municipalities and regions. The main criteria are the impacts on the energy demand, the reinforcement of the economic and social cohesion, the environmental quality and the contribution to the economic development and the employment creation. In this document, realized by Energie-Cites, the Ademe objective is to present a state of the art of french local agencies. Ten agencies are presented as case study. Each case deals with the following topics: the main context of the action which details the energy and the environmental policy of the municipality, the creation and the description of the agency, the implemented actions and the perspectives. (A.L.B.)

  1. Excel 2010 bible

    CERN Document Server

    Walkenbach, John

    2010-01-01

    A comprehensive reference to the newest version of the world's most popular spreadsheet application: Excel 2010 John Walkenbach's name is synonymous with excellence in computer books that decipher complex technical topics. Known as ""Mr. Spreadsheet,"" Walkenbach shows you how to maximize the power of all the new features of Excel 2010. An authoritative reference, this perennial bestseller proves itself indispensable no matter your level of skill, from Excel beginners and intermediate users to power users and potential power users everywhere. Fully updated for the new release, this

  2. Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep.

    Science.gov (United States)

    Sapin, Emilie; Lapray, Damien; Bérod, Anne; Goutagny, Romain; Léger, Lucienne; Ravassard, Pascal; Clément, Olivier; Hanriot, Lucie; Fort, Patrice; Luppi, Pierre-Hervé

    2009-01-01

    Paradoxical sleep (PS) is a state characterized by cortical activation, rapid eye movements and muscle atonia. Fifty years after its discovery, the neuronal network responsible for the genesis of PS has been only partially identified. We recently proposed that GABAergic neurons would have a pivotal role in that network. To localize these GABAergic neurons, we combined immunohistochemical detection of Fos with non-radioactive in situ hybridization of GAD67 mRNA (GABA synthesis enzyme) in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here we show that GABAergic neurons gating PS (PS-off neurons) are principally located in the ventrolateral periaqueductal gray (vlPAG) and the dorsal part of the deep mesencephalic reticular nucleus immediately ventral to it (dDpMe). Furthermore, iontophoretic application of muscimol for 20 min in this area in head-restrained rats induced a strong and significant increase in PS quantities compared to saline. In addition, we found a large number of GABAergic PS-on neurons in the vlPAG/dDPMe region and the medullary reticular nuclei known to generate muscle atonia during PS. Finally, we showed that PS-on neurons triggering PS localized in the SLD are not GABAergic. Altogether, our results indicate that multiple populations of PS-on GABAergic neurons are distributed in the brainstem while only one population of PS-off GABAergic neurons localized in the vlPAG/dDpMe region exist. From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles.

  3. Localization of the brainstem GABAergic neurons controlling paradoxical (REM sleep.

    Directory of Open Access Journals (Sweden)

    Emilie Sapin

    Full Text Available Paradoxical sleep (PS is a state characterized by cortical activation, rapid eye movements and muscle atonia. Fifty years after its discovery, the neuronal network responsible for the genesis of PS has been only partially identified. We recently proposed that GABAergic neurons would have a pivotal role in that network. To localize these GABAergic neurons, we combined immunohistochemical detection of Fos with non-radioactive in situ hybridization of GAD67 mRNA (GABA synthesis enzyme in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here we show that GABAergic neurons gating PS (PS-off neurons are principally located in the ventrolateral periaqueductal gray (vlPAG and the dorsal part of the deep mesencephalic reticular nucleus immediately ventral to it (dDpMe. Furthermore, iontophoretic application of muscimol for 20 min in this area in head-restrained rats induced a strong and significant increase in PS quantities compared to saline. In addition, we found a large number of GABAergic PS-on neurons in the vlPAG/dDPMe region and the medullary reticular nuclei known to generate muscle atonia during PS. Finally, we showed that PS-on neurons triggering PS localized in the SLD are not GABAergic. Altogether, our results indicate that multiple populations of PS-on GABAergic neurons are distributed in the brainstem while only one population of PS-off GABAergic neurons localized in the vlPAG/dDpMe region exist. From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles.

  4. Enhanced Control for Local Helicity Injection on the Pegasus ST

    Science.gov (United States)

    Pierren, C.; Bongard, M. W.; Fonck, R. J.; Lewicki, B. T.; Perry, J. M.

    2017-10-01

    Local helicity injection (LHI) experiments on Pegasus rely upon programmable control of a 250 MVA modular power supply system that drives the electromagnets and helicity injection systems. Precise control of the central solenoid is critical to experimental campaigns that test the LHI Taylor relaxation limit and the coupling efficiency of LHI-produced plasmas to Ohmic current drive. Enhancement and expansion of the present control system is underway using field programmable gate array (FPGA) technology for digital logic and control, coupled to new 10 MHz optical-to-digital transceivers for semiconductor level device communication. The system accepts optical command signals from existing analog feedback controllers, transmits them to multiple devices in parallel H-bridges, and aggregates their status signals for fault detection. Present device-level multiplexing/de-multiplexing and protection logic is extended to include bridge-level protections with the FPGA. An input command filter protects against erroneous and/or spurious noise generated commands that could otherwise cause device failures. Fault registration and response times with the FPGA system are 25 ns. Initial system testing indicates an increased immunity to power supply induced noise, enabling plasma operations at higher working capacitor bank voltage. This can increase the applied helicity injection drive voltage, enable longer pulse lengths and improve Ohmic loop voltage control. Work supported by US DOE Grant DE-FG02-96ER54375.

  5. Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell Tumor

    Directory of Open Access Journals (Sweden)

    Dolly Aguilera

    2008-01-01

    Full Text Available Desmoplastic Small Round Cell Tumor (DSRCT has a very poor prognosis. This report illustrates novel chemotherapy and local control interventions in a 5-year old patient. The patient was treated in the outpatient setting, achieved remission, with excellent quality of life. The patient presented with massive ascites and >1000 abdominal tumors. Neoadjuvant chemotherapy included vincristine (1.5mg/m2, ifosfamide (3g/m2/day×3, dexrazoxane/doxorubicin (750/75mg/m2, and etoposide (150mg/m2. Continuous hyperthermic peritoneal perfusion (CHPP with cisplatin (100mg/m2 was given after extensive cytoreductive surgery. This was followed by irinotecan (10mg/m2/day×5×2weeks + temozolomide monthly × 2, then abdominal radiation 30 Gy with simultaneous temozolomide (100mg/m2/day×5. A total of 12 cycles of irinotecan and temozolamide were given. Except for initial chemotherapy, subsequent courses were in the outpatient setting. Focal retroperitoneal relapse at 18 months was treated with IMRT with bevacizumab (5 mg/kg and 2 perihepatic metastases with radio frequency ablation/cryoablation followed by chronic outpatient maintenance chemotherapy (valproic acid, cyclophosphamide, and rapamycin. Almost 2 years from diagnosis, the patient maintained an excellent quality of life. This is a novel approach to the treatment of children with massive abdomino-pelvic DSRCT.

  6. Dose-painted intensity modulated radiation therapy improves local control for locally advanced pancreas cancer.

    Science.gov (United States)

    Tunceroglu, Ahmet; Park, Joo Han; Balasubramanian, Sairam; Poppe, Matthew; Anker, Christopher J; Poplin, Elizabeth; Moss, Rebecca A; Yue, Ning J; Carpizo, Darren; Gannon, Christopher J; Haffty, Bruce G; Jabbour, Salma K

    2012-01-01

    Background. To evaluate the outcomes, adverse events, and therapeutic role of Dose-Painted Intensity-Modulated Radiation Therapy (DP-IMRT) for locally advanced pancreas cancer (LAPC). Methods. Patients with LAPC were treated with induction chemotherapy (n = 25) and those without metastasis (n = 20) received DP-IMRT consisting of 45 Gy to Planning Treatment Volume 1 (PTV1) including regional lymph nodes with a concomitant boost to the PTV2 (gross tumor volume + 0.5 cm) to either 50.4 Gy (n = 9) or 54 Gy (n = 11) in 25 fractions. DP-IMRT cases were compared to three-dimensional conformal radiation therapy (3D-CRT) plans to assess the potential relationship of radiation dose to adverse events. Kaplan-Meier and Cox regression analyses were used to calculate survival probabilities. The Fisher exact test and t-test were utilized to investigate potential prognostic factors of toxicity and survival. Results. Median overall and progression-free survivals were 11.6 and 5.9 months, respectively. Local control was 90%. Post-RT CA-19-9 levels following RT were predictive of survival (P = 0.02). Grade 2 and ≥grade 3 GI toxicity were 60% and 20%, respectively. In comparison to 3D-CRT, DP-IMRT plans demonstrated significantly lower V45 values of small bowel (P = 0.0002), stomach (P = 0.007), and mean liver doses (P = 0.001). Conclusions. Dose-escalated DP-IMRT offers improved local control in patients treated with induction chemotherapy for LAPC. Radiation-related morbidity appears reduced with DP-IMRT compared to 3D-CRT techniques, likely due to reduction in RT doses to organs at risk.

  7. MoS2-Based Mixed-Dimensional van der Waals Heterostructures: A New Platform for Excellent and Controllable Microwave-Absorption Performance.

    Science.gov (United States)

    Sun, Yuan; Zhong, Wei; Wang, Yuanqi; Xu, Xiaobing; Wang, Tingting; Wu, Liqian; Du, Youwei

    2017-10-04

    It is widely recognized that constructing multiple interface structures for enhanced interface polarization is beneficial to microwave absorption. Here, we report our work of achieving excellent microwave-absorption performance and controlling better-defined interfaces in vertically stacked two-dimensional (2D) MoS 2 with other dimensional building blocks. The optimal reflection loss and effective absorbing bandwidth (reflection loss van der Waals heterostructures are as follows: (i) for 2-0 type (2D MoS 2 /zero-dimensional Ni nanoparticles), -19.7 dB and 2.92 GHz; (ii) for 2-1 type (2D MoS 2 /one-dimensional carbon nanotubes), -47.9 dB and 5.60 GHz; and (iii) for 2-3 type (2D MoS 2 /three-dimensional carbon layers), -69.2 dB and 4.88 GHz. As a result, by selected synthesis of different types of microstructures, we can regulate and control microwave-absorption properties in MoS 2 mixed-dimensional van der Waals heterostructures. In addition, attributing to the better-defined interfaces generated in mixed-dimensional van der Waals heterostructures, we found an alternative strategy to improve microwave attenuation properties of 2-0, 2-1, and 2-3 samples by controlling interfacial contacts. The results indicate that mixed-dimensional van der Waals heterostructures provide a new stage for the next generation of microwave-absorbing materials.

  8. Flutter of wings involving a locally distributed flexible control surface

    Science.gov (United States)

    Mozaffari-Jovin, S.; Firouz-Abadi, R. D.; Roshanian, J.

    2015-11-01

    This paper undertakes to facilitate appraisal of aeroelastic interaction of a locally distributed, flap-type control surface with aircraft wings operating in a subsonic potential flow field. The extended Hamilton's principle serves as a framework to ascertain the Euler-Lagrange equations for coupled bending-torsional-flap vibration. An analytical solution to this boundary-value problem is then accomplished by assumed modes and the extended Galerkin's method. The developed aeroelastic model considers both the inherent flexibility of the control surface displaced on the wing and the inertial coupling between these two flexible bodies. The structural deformations also obey the Euler-Bernoulli beam theory, along with the Kelvin-Voigt viscoelastic constitutive law. Meanwhile, the unsteady thin-airfoil and strip theories are the tools of producing the three-dimensional airloads. The origin of aerodynamic instability undergoes analysis in light of the oscillatory loads as well as the loads owing to arbitrary motions. After successful verification of the model, a systematic flutter survey was conducted on the theoretical effects of various control surface parameters. The results obtained demonstrate that the flapping modes and parameters of the control surface can significantly impact the flutter characteristics of the wings, which leads to a series of pertinent conclusions.

  9. Excel dashboards and reports

    CERN Document Server

    Alexander, Michael

    2013-01-01

    Learn to use Excel dashboards and reports to better conceptualize data Updated for all the?latest features and capabilities of Excel 2013, this go-to resource provides you with in-depth coverage of the individual functions and tools that can be used to create?compelling Excel reports. Veteran author Michael Alexander walks you through the most effective ways to present and report data. Featuring a comprehensive review of a wide array of technical and analytical concepts, this essential guide helps you go from reporting data with simple tables full of dull numbers to presenting

  10. Excel for Cost Engineers

    Science.gov (United States)

    Butts, Glenn C.

    2007-01-01

    Excel is a powerful tool with a plethora of largely unused capabilities that can make the life of an engineer cognizant of them a great deal easier. This paper offers tips, tricks and techniques for better worksheets. Including the use of data validation, conditional formatting, subtotals, text formulas, custom functions and much more. It is assumed that the reader will have a cursory understanding of Excel so the basics will not be covered, if you get hung up try Excel's built in help menus, or a good book.

  11. Excel2003 Formulas

    CERN Document Server

    Walkenbach, John

    2011-01-01

    Everything you need to know about* Mastering operators, error values, naming techniques, and absolute versus relative references* Debugging formulas and using the auditing tools* Importing and exporting XML files and mapping the data to specific cells* Using Excel 2003's rights management feature* Working magic with array formulas* Developing custom formulas to produce the results you needHere's the formula for Excel excellenceFormulas are the lifeblood of spreadsheets, and no one can bring a spreadsheet to life like John Walkenbach. In this detailed reference guide, he delves deeply into unde

  12. Excel 2003 for dummies

    CERN Document Server

    Harvey, Greg

    2013-01-01

    Every time you turn around, you run into Excel. It's on yourPC at work. It's on your PC at home. You get Excel files fromyour boss. Wouldn't you like to understand this powerfulMicrosoft Office spreadsheet program, once and for all? Now, youcan crunch financial data, add sparkle to presentations, convertstatic lists of numbers into impressive charts, and discover whatall the shouting's about regarding databases, formulas, andcells. You may even decide that getting organized with a goodspreadsheet is downright useful and fun! Flip open Excel 2003 For Dummies, and you'llquickly start getting th

  13. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick

    2013-01-01

    Structured Abstract Purpose: Sustainable Enterprise Excellence (SEE) is defined and developed through integration and expansion of business excellence modeling and sustainability thought. The intent is to enable simple yet reliable enterprise assessment of triple bottom line (TBL) performance...... and produce actionable enterprise foresight that can enable next best practices and sources of sustainable competitive advantage through innovation. Methodology: Key elements of SEE are identified from various business excellence and sustainability reporting sources, including the Global Reporting Initiative...... assessment approach similar in structure to those behind established excellence awards are developed that enable enterprise assessment of progress toward SEE. The resulting assessment is delivered in a highly consumable, combined narrative and graphic format referred to as a SEE NEWS Report. Practical...

  14. Herramienta de Análisis y Diseño de Sistemas de Control Basada en Hojas de Cálculo Excel

    Directory of Open Access Journals (Sweden)

    Nourdine Aliane

    2009-10-01

    Full Text Available Resumen: Este artículo presenta una herramienta para el análisis y diseño de sistemas de control basada en hojas de cálculo Excel. Esta herramienta es un conjunto de subrutinas y funciones desarrolladas con el lenguaje VBA. En la actualidad, esta herramienta se limita al manejo de sistemas lineales representados mediante la función de transferencia. El usuario puede especificar modelos, obtener sus respuestas transitorias y en frecuencia, simular un sistema realimentado a través de un controlador, o ajustar los parámetros de un controlador de forma interactiva. Además, la herramienta permite al usuario mantener varias simulaciones en una misma hoja de cálculo, y su carácter interactivo hace posible observar el efecto de varios parámetros sobre el comportamiento de los sistemas de forma inmediata. Para ilustrar el alcance y algunas características de esta herramienta, se han incluido varios ejemplos. Palabras clave: Control, Sistemas lineales, Simulación, Hojas de Calculo

  15. Striving for Excellence

    DEFF Research Database (Denmark)

    Hattke, Fabian; Blaschke, Steffen

    2015-01-01

    no significant effects. Besides top management team composition, we find that a high number of faculties and a broad inclusion of internal status groups (students, tenured faculty, academic and administrative staff) and external stakeholders in decision making processes may enhance academic excellence......, the study contributes to the body of literature on strategic leadership in pluralistic organizations. It highlights the importance of heterogeneous governance structures and modular organization designs for achieving academic excellence. Practical implications: - The paper may inform practitioners...

  16. Numerical investigation of local defectiveness control of diblock copolymer patterns

    Directory of Open Access Journals (Sweden)

    D. Jeong

    2016-09-01

    Full Text Available We numerically investigate local defectiveness control of self-assembled diblock copolymer patterns through appropriate substrate design. We use a nonlocal Cahn-Hilliard (CH equation for the phase separation dynamics of diblock copolymers. We discretize the nonlocal CH equation by an unconditionally stable finite difference scheme on a tapered trench design and, in particular, we use Dirichlet, Neumann, and periodic boundary conditions. The value at the Dirichlet boundary comes from an energy-minimizing equilibrium lamellar profile. We solve the resulting discrete equations using a Gauss-Seidel iterative method. We perform various numerical experiments such as effects of channel width, channel length, and angle on the phase separation dynamics. The simulation results are consistent with the previous experimental observations.

  17. Benefits of the Restorative Exercise and Strength Training for Operational Resilience and Excellence Yoga Program for Chronic Low Back Pain in Service Members: A Pilot Randomized Controlled Trial.

    Science.gov (United States)

    Highland, Krista Beth; Schoomaker, Audrey; Rojas, Winifred; Suen, Josh; Ahmed, Ambareen; Zhang, Zhiwei; Carlin, Sarah Fink; Calilung, Christian E; Kent, Michael; McDonough, Christin; Buckenmaier, Chester C

    2018-01-01

    To examine the feasibility and preliminary effectiveness of an individualized yoga program. Pilot randomized controlled trial. Military medical center. Patients (N=68) with chronic low back pain. Restorative Exercise and Strength Training for Operational Resilience and Excellence (RESTORE) program (9-12 individual yoga sessions) or treatment as usual (control) for an 8-week period. The primary outcome was past 24-hour pain (Defense & Veterans Pain Rating Scale 2.0). Secondary outcomes included disability (Roland-Morris Disability Questionnaire) and physical functioning and symptom burden (Patient-Reported Outcomes Measurement Information System-29 subscales). Assessment occurred at baseline, week 4, week 8, 3-month follow-up, and 6-month follow-up. Exploratory outcomes included the proportion of participants in each group reporting clinically meaningful changes at 3- and 6-month follow-ups. Generalized linear mixed models with sequential Bonferroni-adjusted pairwise significance tests and chi-square analyses examined longitudinal outcomes. Secondary outcome significance tests were Bonferroni adjusted for multiple outcomes. The RESTORE group reported improved pain compared with the control group. Secondary outcomes did not retain significance after Bonferroni adjustments for multiple outcomes, although a higher proportion of RESTORE participants reported clinically meaningfully changes in all outcomes at 3-month follow-up and in symptom burden at 6-month follow-up. RESTORE may be a viable nonpharmacological treatment for low back pain with minimal side effects, and research efforts are needed to compare the effectiveness of RESTORE delivery formats (eg, group vs individual) with that of other treatment modalities. Copyright © 2017 American Congress of Rehabilitation Medicine. All rights reserved.

  18. Does sterilization after chemo-radiotherapy of locally advanced oesophagus cancers predict a better local control?; La sterilisation apres chimioradiotherapie des cancers oesophagiens localement evolues predit-elle un meilleur controle local?

    Energy Technology Data Exchange (ETDEWEB)

    Ruffier-Loubiere, A.; Chapet, S.; Garaud, P.; Lande de Calan, L. de la; Calais, G. [CHU Bretonneau, Tours (France)

    2011-10-15

    The authors report a retrospective study which aimed at determining whether 'sterilization of the operating piece' for 102 patients treated between 1999 and 2010 after concomitant chemo-radiotherapy for an oesophagus cancer is correlated by a better local control rate, acceptable morbidity and mortality rates. They also aimed at analyzing the impact of a tumour or ganglionary down-staging on the local-regional control and survival without disease. Short communication

  19. The renewal of excellence.

    Science.gov (United States)

    Halawi, Mohamad J

    2014-10-01

    Excellence in orthopaedic surgery has been a long time in the making. What we currently enjoy reflects over a century of innovation, leadership, and consummate professionalism. Today, our practice faces monumental challenges that have never been more demanding, and our commitment to the preservation and advancement of excellence has never been more pressing. Away from the scientific tone but without romanticizing our proud heritage, this article seeks to revitalize the values that have defined our practice, drawing on the wisdom and experiences of leaders in our field. Collectively, it aims to stimulate our enlightened understanding, to reignite our hopes, and to reaffirm our commitment to the highest standards of excellence. Copyright © 2014 by The Journal of Bone and Joint Surgery, Incorporated.

  20. Paternity analysis in Excel.

    Science.gov (United States)

    Rocheta, Margarida; Dionísio, F Miguel; Fonseca, Luís; Pires, Ana M

    2007-12-01

    Paternity analysis using microsatellite information is a well-studied subject. These markers are ideal for parentage studies and fingerprinting, due to their high-discrimination power. This type of data is used to assign paternity, to compute the average selfing and outcrossing rates and to estimate the biparental inbreeding. There are several public domain programs that compute all this information from data. Most of the time, it is necessary to export data to some sort of format, feed it to the program and import the output to an Excel book for further processing. In this article we briefly describe a program referred from now on as Paternity Analysis in Excel (PAE), developed at IST and IBET (see the acknowledgments) that computes paternity candidates from data, and other information, from within Excel. In practice this means that the end user provides the data in an Excel sheet and, by pressing an appropriate button, obtains the results in another Excel sheet. For convenience PAE is divided into two modules. The first one is a filtering module that selects data from the sequencer and reorganizes it in a format appropriate to process paternity analysis, assuming certain conventions for the names of parents and offspring from the sequencer. The second module carries out the paternity analysis assuming that one parent is known. Both modules are written in Excel-VBA and can be obtained at the address (www.math.ist.utl.pt/~fmd/pa/pa.zip). They are free for non-commercial purposes and have been tested with different data and against different software (Cervus, FaMoz, and MLTR).

  1. Programming Excel services

    CERN Document Server

    Bruney, Alvin J

    2007-01-01

    Learn how to use Excel Services to add spreadsheets and workbooks to your enterprise dashboards and portals. You get real-world examples and code samples to help you enable business intelligence on Microsoft Office SharePoint Server 2007 applications-and simplify information sharing and reuse. Discover how to: Configure Windows SharePoint Products and Technologies, and provision Excel ServicesBuild and debug Web Parts derived from Microsoft .NET Framework or SharePoint base classes Customize and embed objects into Web PartsExtract workbook contents and bind the results to user interface con

  2. Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Williams, Joseph; Eskildsen, Jacob Kjær

    Sustainable Enterprise Excellence balances complementary and competing interests of key stakeholder segments, including society and the natural environment and increases the likelihood of superior and sustainable competitive positioning and hence long-term enterprise success that is defined...... by continuously relevant and responsible governance, strategy, actions and performance consistent with high-level organizational resilience, robustness and resplendence (R3). This is accomplished through organizational design and function emphasizing innovation, enterprise intelligence & analytics, operational......, supply chain, customer-related, human capital, financial, marketplace, societal, and environmental performance. Sustainable Enterprise Excellence integrates ethical, efficient and effective (E3) enterprise governance with 3E (equity, ecology, economy) Triple Top Line strategy throughout enterprise...

  3. Microsoft Excel 2007 - Manual

    OpenAIRE

    Roque, Vítor

    2009-01-01

    O Microsoft Excel faz parte do "Office", um pacote de produtos que combinam vários tipos de software para criar documentos, folhas de cálculo, apresentações e para gerir correio electrónico. Nesta nova versão, o Microsoft Excel surge com uma nova interface, onde os tradicionais menus de opções desaparecem e dão lugar a um friso com diversos separadores onde podemos encontrar, mais facilmente, os comandos necessários à execução das tarefas que nos propomos realizar. O obje...

  4. Radiotherapy in desmoid tumors. Treatment response, local control, and analysis of local failures

    Energy Technology Data Exchange (ETDEWEB)

    Santti, Kirsi; Beule, Annette; Tuomikoski, Laura; Jaeaeskelaeinen, Anna-Stina; Saarilahti, Kauko; Tarkkanen, Maija; Blomqvist, Carl [Helsinki University Hospital and University of Helsinki, Comprehensive Cancer Center, Helsinki (Finland); Roenty, Mikko [HUSLAB and University of Helsinki, Department of Pathology, Helsinki (Finland); Ihalainen, Hanna [Helsinki University Hospital and University of Helsinki, Department of Plastic Surgery, Helsinki (Finland)

    2017-04-15

    Desmoid tumors (aggressive fibromatosis) are rare soft tissue tumors which frequently recur after surgery. Desmoid tumors arise from musculoaponeurotic tissue in the extremities, head and neck, abdominal wall, or intra-abdominally. Our aim was to examine the outcome of radiotherapy of desmoid tumors in a single institution series. We evaluated 41 patients with desmoid tumors treated with 49 radiotherapies between 1987 and 2012. Radiologic images for response evaluation were reassessed and responses to treatment registered according to RECIST criteria 1.1. For patients with local failures radiation dose distribution was determined in each local failure volume using image co-registration. Recurrences were classified as in-target, marginal, or out-of-target. Prognostic factors for radiotherapy treatment failure were evaluated. Radiotherapy doses varied from 20-63 Gy (median 50 Gy) with a median fraction size of 2 Gy. The objective response rate to definitive radiotherapy was 55% (12/22 patients). Median time to response was 14 months. A statistically significant dose-response relation for definitive and postoperative radiotherapy was observed both in univariate (p-value 0.002) and in multivariate analysis (p-value 0.02) adjusted for potential confounding factors. Surgery before radiotherapy or surgical margin had no significant effect on time to progression. Nine of 11 (82%) local failures were classified as marginal and two of 11 (18%) in-target. None of the recurrences occurred totally out-of-target. Radiotherapy is a valuable option for treating desmoid tumors. Radiotherapy dose appears to be significantly associated to local control. (orig.) [German] Desmoide (aggressive Fibromatosen) sind seltene Weichteiltumore der muskulaeren Membranen von Kopf, Hals, Extremitaeten und Bauchwand. Ziel war es, die Wirksamkeit der Strahlentherapie bei aggressiver Fibromatose an einer einzelnen Klinik zu untersuchen. Ausgewertet wurden 41 Patienten mit aggressiver Fibromatose, die

  5. Patient satisfaction: focusing on "excellent".

    Science.gov (United States)

    Otani, Koichiro; Waterman, Brian; Faulkner, Kelly M; Boslaugh, Sarah; Burroughs, Thomas E; Dunagan, W Claiborne

    2009-01-01

    In an emerging competitive market such as healthcare, managers should focus on achieving excellent ratings to distinguish their organization from others. When it comes to customer loyalty, "excellent" has a different meaning. Customers who are merely satisfied often do not come back. The purpose of this study was to find out what influences adult patients to rate their overall experience as "excellent." The study used patient satisfaction data collected from one major academic hospital and four community hospitals. After conducting a multiple logistic regression analysis, certain attributes were shown to be more likely than others to influence patients to rate their experiences as excellent. The study revealed that staff care is the most influential attribute, followed by nursing care. These two attributes are distinctively stronger drivers of overall satisfaction than are the other attributes studied (i.e., physician care, admission process, room, and food). Staff care and nursing care are under the control of healthcare managers. If improvements are needed, they can be accomplished through training programs such as total quality management or continuous quality improvement, through which staff employees and nurses learn to be sensitive to patients' needs. Satisfying patients' needs is the first step toward having loyal patients, so hospitals that strive to ensure their patients are completely satisfied are more likely to prosper.

  6. Statistische toetsen in Excel

    NARCIS (Netherlands)

    A.A.J. van Peet; H.A. Everaert

    2007-01-01

    In KG-18 hebben we verschillende grafieken laten zien. Een veel gebruikte grafische figuur in de statistiek is de zogenaamde boxplot. Weliswaar wordt deze niet vermeld bij de standaard keuzemogelijkheden onder de Wizard Grafieken, toch is het mogelijk om deze figuur met behulp van Excel te tekenen.

  7. Enlisting Excel--Again

    Science.gov (United States)

    Parramore, Keith

    2009-01-01

    In Volume 26, Number 2, we reported on a group case study run for level 3 mathematics students at the University of Brighton. At the core of the study was a quadratic assignment problem, and we reported on attempts by students to use Excel to solve the problem, and on the attendant difficulties. We provided an elegant solution. In this article, we…

  8. Local control stations: Human engineering issues and insights

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.S.; Higgins, J.C.; O`Hara, J.M. [Brookhaven National Lab., Upton, NY (United States)

    1994-09-01

    The objective of this research project was to evaluate current human engineering at local control stations (LCSs) in nuclear power plants, and to identify good human engineering practices relevant to the design of these operator interfaces. General literature and reports of operating experience were reviewed to determine the extent and type of human engineering deficiencies at LCSs in nuclear power plants. In-plant assessments were made of human engineering at single-function as well as multifunction LCSs. Besides confirming the existence of human engineering deficiencies at LCSs, the in-plant assessments provided information about the human engineering upgrades that have been made at nuclear power plants. Upgrades were typically the result of any of three influences regulatory activity, broad industry initiatives such as INPO, and specific in-plant programs (e.g. activities related to training). It is concluded that the quality of LCSs is quite variable and might be improved if there were greater awareness of good practices and existing human engineering guidance relevant to these operator interfaces, which is available from a variety of sources. To make such human engineering guidance more readily accessible, guidelines were compiled from such sources and included in the report as an appendix.

  9. Commitment to project management excellence

    Energy Technology Data Exchange (ETDEWEB)

    Bates, J. [Westinghouse Savannah River Company, Aiken, SC (United States)

    1994-12-31

    The paper discusses the commitment of the United States Department of Energy (DOE) to excellence in developing and implementing new project management and project control guidelines and in developing a training course. For the new Project Control Systems (PCS) Guidelines, DOE has consistently applied the precepts of Total Quality Management in the way problems were identified and resolved, in the use of techniques to develop the new guidance, and in the use of methods to create the new manager training. With the guidelines, DOE has responded to administration policy in developing a cost-effective, streamlined, and quantitative performance measurement. 3 refs.

  10. Malaria Prevalence and Local Beliefs in Transmission and Control ...

    African Journals Online (AJOL)

    , too much exposure to sunlight 25.3%, eating of oily foods 16.7%, cold weather 14.2% and witchcraft 1.2%. There was a statistical difference among the local beliefs on transmission. Local beliefs associated with malaria prevention in the ...

  11. Supervisor localization a top-down approach to distributed control of discrete-event systems

    CERN Document Server

    Cai, Kai

    2016-01-01

    This monograph presents a systematic top-down approach to distributed control synthesis of discrete-event systems (DES). The approach is called supervisor localization; its essence is the allocation of external supervisory control action to individual component agents as their internal control strategies. The procedure is: first synthesize a monolithic supervisor, to achieve globally optimal and nonblocking controlled behavior, then decompose the monolithic supervisor into local controllers, one for each agent. The collective behavior of the resulting local controllers is identical to that achieved by the monolithic supervisor. The basic localization theory is first presented in the Ramadge–Wonham language-based supervisory control framework, then demonstrated with distributed control examples of multi-robot formations, manufacturing systems, and distributed algorithms. An architectural approach is adopted to apply localization to large-scale DES; this yields a heterarchical localization procedure, which is...

  12. Optimal Local Dimming for LC Image Formation With Controllable Backlighting

    DEFF Research Database (Denmark)

    Shu, Xiao; Wu, Xiaolin; Forchhammer, Søren

    2013-01-01

    Light emitting diode (LED)-backlit liquid crystal displays (LCDs) hold the promise of improving image quality while reducing the energy consumption with signal-dependent local dimming. However, most existing local dimming algorithms are mostly motivated by simple implementation, and they often lack...... concern for visual quality. To fully realize the potential of LED-backlit LCDs and reduce the artifacts that often occur in current systems, we propose a novel local dimming technique that can achieve the theoretical highest fidelity of intensity reproduction in either $\\ell_{1}$ or $\\ell_{2}$ metrics...

  13. Localized field control at the nano-scale

    Science.gov (United States)

    Fujiwara, Hideki; Yasuda, Yuki; Orita, Hiroaki; Ishida, Shutaro; Sasaki, Keiji

    2017-04-01

    We investigate the wavelength dependence of localized plasmonic field distributions in a gold nanodimer structure under total internal reflection condition. Although a gold dimer structure is well known to induce strong localized mode at a nanogap, we find that the higher-order plasmonic modes are excited by the oblique light incidence and their interference effect enables us to observe the modification of localized filed distributions at the nano-scale even in a simple gold nanodimer structure depending on the detection wavelength. This change in the plasmonic field distribution would provide important knowledge for their potential applications such as plasmonic trapping, spectroscopy, and sensing.

  14. Formal Law and Local Water Control in the Andean Region: A Fiercely Contested Field

    NARCIS (Netherlands)

    Vos, de H.; Boelens, R.A.; Bustamente, R.R.

    2006-01-01

    Water access and control rights of peasant and indigenous communities in Andean countries are threatened. Vertical state law and intervention practices, as well as new privatization policies generally ignore, discriminate or undermine local normative frameworks. Recognition of diverse local rights

  15. A local control strategy for power systems in transient emergency state; Part 1: functional design

    Energy Technology Data Exchange (ETDEWEB)

    Aliyu, U.; El-Abiad, A.H.

    1982-11-01

    This paper is concerned with the investigation of a systematic corrective control approach for the transient emergency state problem of the power system. The proposed new control framework involves distributing the task of system transient stability margin improvement among several local facilities dedicated to the various subsystems comprising the power system. The functional design of the various local controllers to undertake local information processing and provide appropriate closed-loop stabilizing control action during severe transient disturbance is presented. An illustrative example is included to demonstrate the effectiveness of the proposed local control framework.

  16. Supervisor Localization: A Top-Down Approach to Distributed Control of Discrete-Event Systems

    Science.gov (United States)

    Cai, K.; Wonham, W. M.

    2009-03-01

    A purely distributed control paradigm is proposed for discrete-event systems (DES). In contrast to control by one or more external supervisors, distributed control aims to design built-in strategies for individual agents. First a distributed optimal nonblocking control problem is formulated. To solve it, a top-down localization procedure is developed which systematically decomposes an external supervisor into local controllers while preserving optimality and nonblockingness. An efficient localization algorithm is provided to carry out the computation, and an automated guided vehicles (AGV) example presented for illustration. Finally, the 'easiest' and 'hardest' boundary cases of localization are discussed.

  17. Excel 2007 Charts

    CERN Document Server

    Walkenbach, John

    2008-01-01

    Excel, the top number-crunching tool, now offers a vastly improved charting function to help you give those numbers dimension and relativity. John Walkenbach, a.k.a. Mr. Spreadsheet, clearly explains all these charting features and shows you how to choose the right chart for your needs. You'll learn to modify data within the chart, deal with missing data, format your chart, use trend lines, construct "impossible" charts, create charts from pivot tables, dress them up with graphics, and more. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

  18. Solving rational expectations models using Excel

    DEFF Research Database (Denmark)

    Strulik, Holger

    2004-01-01

    Problems of discrete time optimal control can be solved using backward iteration and Microsoft Excel. The author explains the method in general and shows how the basic models of neoclassical growth and real business cycles are solved...

  19. Precise Localization and Control of Catalytic Janus Micromotors using Weak Magnetic Fields

    NARCIS (Netherlands)

    Khalil, Islam S. M.; Magdanz, Veronika; Sanchez, Samuel; Schmidt, Oliver G.; Misra, Sarthak

    2015-01-01

    We experimentally demonstrate the precise localization of spherical Pt-Silica Janus micromotors (diameter 5 mu m) under the influence of controlled magnetic fields. First, we control the motion of the Janus micromotors in two-dimensional (2D) space. The control system achieves precise localization

  20. Controlling local order of athermal self-propelled particles

    Science.gov (United States)

    Dougan, Niamh; Crowther, Peter; Royall, C. Patrick; Turci, Francesco

    2016-12-01

    We consider a model of self-propelled dynamics for athermal active particles, where the non-equilibrium active forces are modelled by a Ornstein-Uhlenbeck process. In the limit of no-driving force, the model reduces to the passive, Brownian dynamics of an atomistic glass forming fluid, the Wahnström binary mixture. The Wahnström mixture is known to show strong correlations between the emergence of slow dynamics and the formation of locally favoured structures based on icosahedra. Here, we study how the non-equilibrium driving affects the local structure of the system, and find that it strongly promotes icosahedral order. The states rich in local icosahedral order correspond to configurations of very low potential energy, suggesting that the non-equilibrium dynamics in the self propelled model can be effectively exploited to explore the potential energy surface of the binary mixture and have access to states that are difficult to attain using passive dynamics.

  1. Excel 2010 Workbook for Dummies

    CERN Document Server

    Harvey, Greg

    2010-01-01

    Reinforce your understanding of Excel with these Workbook exercises. Boost your knowledge of important Excel tasks by putting your skills to work in real-world situations. The For Dummies Workbook format provides more than 100 exercises that help you create actual results with Excel so you can gain proficiency. Perfect for students, people learning Excel on their own, and financial professionals who must plan and execute complex projects in Excel, Excel 2010 Workbook For Dummies helps you discover all the ways this program can work for you.: Excel is the world's most popular number-crunching p

  2. Adjuvant Radiation Therapy Improves Local Control After Surgical Resection in Patients With Localized Adrenocortical Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Sabolch, Aaron [Department of Radiation Oncology, University of Michigan Hospital and Health Systems, Ann Arbor, Mchigan (United States); Else, Tobias [Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Hospital and Health Systems, Ann Arbor, Mchigan (United States); Griffith, Kent A. [Center for Cancer Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Mchigan (United States); Ben-Josef, Edgar [Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Williams, Andrew [University of Michigan Medical School, Ann Arbor, Mchigan (United States); Miller, Barbra S. [Division of Endocrine Surgery, Department of General Surgery, University of Michigan Hospital and Health Systems, Ann Arbor, Mchigan (United States); Worden, Francis [Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Hospital and Health Systems, Ann Arbor, Mchigan (United States); Hammer, Gary D. [Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Hospital and Health Systems, Ann Arbor, Mchigan (United States); Jolly, Shruti, E-mail: shrutij@med.umich.edu [Department of Radiation Oncology, University of Michigan Hospital and Health Systems, Ann Arbor, Mchigan (United States)

    2015-06-01

    Purpose: Adrenocortical carcinoma (ACC) is a rare malignancy known for high rates of local recurrence, though the benefit of postoperative radiation therapy (RT) has not been established. In this study of grossly resected ACC, we compare local control of patients treated with surgery followed by adjuvant RT to a matched cohort treated with surgery alone. Methods and Materials: We retrospectively identified patients with localized disease who underwent R0 or R1 resection followed by adjuvant RT. Only patients treated with RT at our institution were included. Matching to surgical controls was on the basis of stage, surgical margin status, tumor grade, and adjuvant mitotane. Results: From 1991 to 2011, 360 ACC patients were evaluated for ACC at the University of Michigan (Ann Arbor, MI). Twenty patients with localized disease received postoperative adjuvant RT. These were matched to 20 controls. There were no statistically significant differences between the groups with regard to stage, margins, grade, or mitotane. Median RT dose was 55 Gy (range, 45-60 Gy). Median follow-up was 34 months. Local recurrence occurred in 1 patient treated with RT, compared with 12 patients not treated with RT (P=.0005; hazard ratio [HR] 12.59; 95% confidence interval [CI] 1.62-97.88). However, recurrence-free survival was no different between the groups (P=.17; HR 1.52; 95% CI 0.67-3.45). Overall survival was also not significantly different (P=.13; HR 1.97; 95% CI 0.57-6.77), with 4 deaths in the RT group compared with 9 in the control group. Conclusions: Postoperative RT significantly improved local control compared with the use of surgery alone in this case-matched cohort analysis of grossly resected ACC patients. Although this retrospective series represents the largest study to date on adjuvant RT for ACC, its findings need to be prospectively confirmed.

  3. Feasibility analysis of field bus utilization for local control of electric systems; Analisis de factibilidad de utilizacion de fieldbuses para control local de sistemas electricos

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Fabiana; Feldgen, Maria; Clua, Osvaldo [Buenos Aires Univ., Buenos Aires (Argentina). Faculdad de Ingenieria

    2001-07-01

    For accomplish with local electric systems control is necessary to command and supervise separated equipment for various hundred meters. The traditional solution consists in communication between equipment with a control station central supervision, through a cabled network. Important advantages are obtained by changing to a solution where control are performed in a distributed way and using a local normalized network known as field bus. This paper resumes the main characteristics of these buses. Some conclusions are obtained related to the application of these type of protocols for the substation control and criteria are established for the selection among various available technologies.

  4. Local government in Ethiopia: still an apparatus of control? | Ayele ...

    African Journals Online (AJOL)

    Historically, local authorities in Ethiopia enjoyed wide political, administrative, judicial, and financial autonomy. However, from the 1850s a process of territorial expansion and centralisation was initiated in the country. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD ...

  5. Tumor control outcomes of patients treated with trimodality therapy for locally advanced prostate cancer.

    Science.gov (United States)

    Copp, Hillary; Bissonette, Eric A; Theodorescu, Dan

    2005-06-01

    To evaluate, in a pilot study, the tumor control outcomes of our approach and define the pretreatment characteristics that predict a response to therapy. Patients with advanced clinically localized prostate cancer have a high likelihood of prostate-specific antigen (PSA) failure 3 to 5 years after initial treatment. We adopted trimodality therapy (neoadjuvant and adjuvant androgen ablation, external beam radiotherapy [RT], and a brachytherapy boost) to augment biochemical disease-free survival in this patient population. From 1997 to 2000, 93 patients with clinical Stage T2b or greater, or PSA level greater than 10 ng/mL, or Gleason score 7 or greater were treated with external beam RT followed by palladium-103 brachytherapy. Two to three months before external beam RT, an 8 to 9-month regimen of leuprolide and an oral antiandrogen was initiated. Patients were followed up at 3 to 4-month intervals with PSA determination and digital rectal examination. Perineural invasion, the percentage of cancer in biopsy cores, pretreatment PSA level, clinical T stage, and Gleason score were analyzed as prognostic factors for biochemical failure defined by both the American Society for Therapeutic Radiology and Oncology (ASTRO) criteria and PSA level greater than 0.2 ng/mL. The median length of follow-up was 45 months. The overall probability of biochemical failure using a PSA level greater than 0.2 ng/mL at 4 years was 79% (95% confidence interval 69% to 89%). With the ASTRO criteria, the overall failure rate at the same point was 77% (95% confidence interval 68% to 87%). Gleason score (P = 0.07) showed a trend toward predicting biochemical failure using the PSA level greater than 0.2 ng/mL criterion. Trimodality RT offers excellent tumor control in patients with poor prognosis who often relapse early. Longer follow-up will be important to determine whether these results are durable over time.

  6. Streamlining Local Behaviour Through Communication, Incentives and Control: A Case Study of Local Environmental Policies in China

    Directory of Open Access Journals (Sweden)

    Thomas Heberer

    2011-01-01

    Full Text Available This article describes how China uses evaluation ratings and monitoring as incentives in order to foster the implementation of environmental policies at the local level. It is argued that decentralisation in China leaves room for actors at the local levels to manoeuver and bargain with those on higher levels for flexible adjustment of implementation policies according to local conditions. However, decentralisation is accompanied by significant institutional changes in the structure of intergovernmental communication, incentives and control. Accordingly, decentralisation in China exhibits a specific design which leaves space for divergent local environmental policies while also engendering “grass-roots mechanisms”. On the whole, this new institutional setting benefits the implementation of environmental policies.

  7. Mutual influence of locality and chaotic dynamics on quantum controllability

    Science.gov (United States)

    Kallush, S.; Kosloff, R.

    2012-07-01

    Quantum control tasks are classified either as classical-like or as quantum requiring interference of pathways. We study the generation of interference pathways and relate them to the fidelity of the control target at a fixed time for various tasks. The model drift Hamiltonian studied is the two-dimensional Henon-Heiles (HH) potential. This system shows regular classical dynamics for low energies and chaotic dynamics for higher energies. A control operator supported by the whole momentum space and therefore connecting the entire Hilbert phase space is a random spiky potential. The other extreme is a smooth control potential. Intermediate cases are obtained by filtering the random spiky potential in momentum space. The fidelity of achieving a control task was related to the connectivity in phase space of the control operators. Typical quantum tasks such as generating a superposition of generalized coherent states rely on interfering pathways. For these cases the nonlinearity in the drift or control Hamiltonian is a necessary requirement for creating interferences. Control over rapidly diverging components of the wave function is achieved by the use of highly nonlocal control operators. Quantum control under chaotic drift was found to give a better yield than control under regular dynamics for such cases. For classical tasks we study the transformation of an initial generalized coherent state to another one. The best fidelity is obtained for regular or harmonic regions of the potential and smooth control operators. The approach to the classical limit is checked by decreasing the effective value of ℏ. Control under both quantum and classical tasks suffered from the decrease of ℏ and the approach to classical proximity. Classical control tasks which rely heavily on maintaining a generalized coherent state throughout the evolution were found to be dysfunctional and lead to a completely uncontrolled situation once the classical chaos starts to appear.

  8. Local geology controlled the feasibility of vitrifying Iron Age buildings

    Science.gov (United States)

    Fabian B Wadsworth,; Michael J Heap,; Damby, David; Kai-Uwe Hess,; Jens Najorka,; Jérémie Vasseur,; Dominik Fahrner,; Donald B Dingwell,

    2017-01-01

    During European prehistory, hilltop enclosures made from polydisperse particle-and-block stone walling were exposed to temperatures sufficient to partially melt the constituent stonework, leading to the preservation of glassy walls called ‘vitrified forts’. During vitrification, the granular wall rocks partially melt, sinter viscously and densify, reducing inter-particle porosity. This process is strongly dependent on the solidus temperature, the particle sizes, the temperature-dependence of the viscosity of the evolving liquid phase, as well as the distribution and longevity of heat. Examination of the sintering behaviour of 45 European examples reveals that it is the raw building material that governs the vitrification efficiency. As Iron Age forts were commonly constructed from local stone, we conclude that local geology directly influenced the degree to which buildings were vitrified in the Iron Age. Additionally, we find that vitrification is accompanied by a bulk material strengthening of the aggregates of small sizes, and a partial weakening of larger blocks. We discuss these findings in the context of the debate surrounding the motive of the wall-builders. We conclude that if wall stability by bulk strengthening was the desired effect, then vitrification represents an Iron Age technology that failed to be effective in regions of refractory local geology.

  9. Local geology controlled the feasibility of vitrifying Iron Age buildings.

    Science.gov (United States)

    Wadsworth, Fabian B; Heap, Michael J; Damby, David E; Hess, Kai-Uwe; Najorka, Jens; Vasseur, Jérémie; Fahrner, Dominik; Dingwell, Donald B

    2017-01-12

    During European prehistory, hilltop enclosures made from polydisperse particle-and-block stone walling were exposed to temperatures sufficient to partially melt the constituent stonework, leading to the preservation of glassy walls called 'vitrified forts'. During vitrification, the granular wall rocks partially melt, sinter viscously and densify, reducing inter-particle porosity. This process is strongly dependent on the solidus temperature, the particle sizes, the temperature-dependence of the viscosity of the evolving liquid phase, as well as the distribution and longevity of heat. Examination of the sintering behaviour of 45 European examples reveals that it is the raw building material that governs the vitrification efficiency. As Iron Age forts were commonly constructed from local stone, we conclude that local geology directly influenced the degree to which buildings were vitrified in the Iron Age. Additionally, we find that vitrification is accompanied by a bulk material strengthening of the aggregates of small sizes, and a partial weakening of larger blocks. We discuss these findings in the context of the debate surrounding the motive of the wall-builders. We conclude that if wall stability by bulk strengthening was the desired effect, then vitrification represents an Iron Age technology that failed to be effective in regions of refractory local geology.

  10. Supply Chain Control Principles in Local Food Production: A Norwegian Case Study

    Directory of Open Access Journals (Sweden)

    Heidi C. Dreyer

    2014-08-01

    Full Text Available Based on an analysis of the supply chain of four producers of local specialty foods, we explore how planning and control principles can be applied to align supply chain capabilities and market requirements. It has been shown that local food struggles with market access, and that the supply chain is one of the obstacles preventing local food producers from gaining a solid market position. We identify a number of features of the local food chain, analyse the obstacles and develop generic designs and control principles for local food producers.

  11. Traditional methods of social control in Afikpo north local ...

    African Journals Online (AJOL)

    This paper examined the traditional social control mechanisms in Afikpo North LGA of Ebonyi state, south eastern Nigeria. The rising trend in extraneous crimes and vices like kidnapping, baby factories, drug peddling among others seem to be overwhelming for modern social control mechanisms. This has lent credence to ...

  12. Community Participation in Malaria Control in Olorunda Local ...

    African Journals Online (AJOL)

    Malaria is a major health burden in developing countries and needs multiple strategies for its control. Community participation as one of the strategies for malaria control promotes self-awareness and confidence, causes the people to examine the problems and to think positively about the solutions. The study was aimed at ...

  13. Accountability, Corruption and Local Government: Mapping the Control Steps

    National Research Council Canada - National Science Library

    Ana Luiza Melo Aranha

    2017-01-01

    The central purpose of this paper is to map out the Brazilian web of accountability institutions and observe how institutions establish links with each other in order to control corruption cases that reach...

  14. Local, distributed topology control for large-scale wireless ad-hoc networks

    NARCIS (Netherlands)

    Nieberg, T.; Hurink, Johann L.

    In this document, topology control of a large-scale, wireless network by a distributed algorithm that uses only locally available information is presented. Topology control algorithms adjust the transmission power of wireless nodes to create a desired topology. The algorithm, named local power

  15. Local Control, Democracy, and the Separation in the Public Opinion of School Finance Reform

    Science.gov (United States)

    Shelly, Bryan

    2007-01-01

    What role does a person's support for local educational control play in determining her attitude towards equity-minded school finance reform? This article reports estimations of binary and ordered probit models of two state public opinion polls and discusses newspaper coverage from the same two states to determine if and how local control has such…

  16. Scalable Harmonization of Complex Networks With Local Adaptive Controllers

    Czech Academy of Sciences Publication Activity Database

    Kárný, Miroslav; Herzallah, R.

    2017-01-01

    Roč. 47, č. 3 (2017), s. 394-404 ISSN 2168-2216 R&D Projects: GA ČR GA13-13502S Institutional support: RVO:67985556 Keywords : Adaptive control * Adaptive estimation * Bayes methods * Complex networks * Decentralized control * Feedback * Feedforward systems * Recursive estimation Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 2.350, year: 2016 http://library.utia.cas.cz/separaty/2016/AS/karny-0457337.pdf

  17. Wettability controls slow immiscible displacement through local interfacial instabilities

    Science.gov (United States)

    Jung, Michael; Brinkmann, Martin; Seemann, Ralf; Hiller, Thomas; Sanchez de La Lama, Marta; Herminghaus, Stephan

    2016-11-01

    Immiscible fluid displacement with average front velocities in the capillary-dominated regime is studied in a transparent Hele-Shaw cell with cylindrical posts. Employing various combinations of fluids and wall materials allows us to cover a range of advancing contact angles 46∘≤θa≤180∘ of the invading fluid in our experiments. In parallel, we study the displacement process in particle-based simulations that account for wall wettability. Considering the same arrangement of posts in experiments and simulation, we find a consistent crossover between stable interfacial displacement at θa≲80∘ and capillary fingering at high contact angles θa≳120∘ . The position of the crossover is quantified through the evolution of the interface length and the final saturation of the displaced fluid. A statistical analysis of the local displacement processes demonstrates that the shape evolution of the fluid front is governed by local instabilities as proposed by Cieplak and Robbins for a quasistatic interfacial displacement [Cieplak and Robbins, Phys. Rev. Lett. 60, 2042 (1988), 10.1103/PhysRevLett.60.2042]. The regime of stable front advances coincides with a corresponding region of contact angles where cooperative interfacial instabilities prevail. Capillary fingering, however, is observed only for large θa, where noncooperative instabilities dominate the invasion process.

  18. Decreased local control following radiation therapy alone in early-stage glottic carcinoma with anterior commissure extension

    Energy Technology Data Exchange (ETDEWEB)

    Zouhair, A.; Azria, D.; Coucke, P.; Matzinger, O.; Mirimanoff, R.O.; Ozsahin, M. [Dept. of Radiation Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne (Switzerland); Bron, L. [Dept. of Otorhinolaryngology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne (Switzerland); Moeckli, R.; Do, H.P. [Inst. of Applied Radiophysics (IRA), Lausanne (Switzerland)

    2004-02-01

    Purpose: to assess the patterns of failure in the treatment of early-stage squamous cell carcinoma of the glottic larynx. Patients and methods: between 1983-2000, 122 consecutive patients treated for early laryngeal cancer (UICC T1N0 and T2N0) by radical radiation therapy (RT) were retrospectively studied. Male-to-female ratio was 106: 16, and median age 62 years (35-92 years). There were 68 patients with T1a, 18 with T1b, and 36 with T2 tumors. Diagnosis was made by biopsy in 104 patients, and by laser vaporization or stripping in 18. Treatment planning consisted of three-dimensional (3-D) conformal RT in 49 (40%) patients including nine patients irradiated using arytenoid protection. A median dose of 70 Gy (60-74 Gy) was given (2 Gy/fraction) over a median period of 46 days (21-79 days). Median follow-up period was 85 months. Results: the 5-year overall, cancer-specific, and disease-free survival amounted to 80%, 94%, and 70%, respectively. 5-year local control was 83%. Median time to local recurrence in 19 patients was 13 months (5-58 months). Salvage treatment consisted of surgery in 17 patients (one patient refused salvage and one was inoperable; total laryngectomy in eleven, and partial laryngectomy or cordectomy in six patients). Six patients died because of laryngeal cancer. Univariate analyses revealed that prognostic factors negatively influencing local control were anterior commissure extension, arytenoid protection, and total RT dose < 66 Gy. Among the factors analyzed, multivariate analysis (cox model) demonstrated that anterior commissure extension, arytenoid protection, and male gender were the worst independent prognostic factors in terms of local control. Conclusion: for early-stage laryngeal cancer, outcome after RT is excellent. In case of anterior commissure extension, surgery or higher RT doses are warranted. Because of a high relapse risk, arytenoid protection should not be attempted. (orig.)

  19. Stable and metastable nanowires displaying locally controllable properties

    Science.gov (United States)

    Sutter, Eli Anguelova; Sutter, Peter Werner

    2014-11-18

    Vapor-liquid-solid growth of nanowires is tailored to achieve complex one-dimensional material geometries using phase diagrams determined for nanoscale materials. Segmented one-dimensional nanowires having constant composition display locally variable electronic band structures that are determined by the diameter of the nanowires. The unique electrical and optical properties of the segmented nanowires are exploited to form electronic and optoelectronic devices. Using gold-germanium as a model system, in situ transmission electron microscopy establishes, for nanometer-sized Au--Ge alloy drops at the tips of Ge nanowires (NWs), the parts of the phase diagram that determine their temperature-dependent equilibrium composition. The nanoscale phase diagram is then used to determine the exchange of material between the NW and the drop. The phase diagram for the nanoscale drop deviates significantly from that of the bulk alloy.

  20. Bearing-based localization for leader-follower formation control

    Science.gov (United States)

    Han, Qing; Ren, Shan; Lang, Hao; Zhang, Changliang

    2017-01-01

    The observability of the leader robot system and the leader-follower formation control are studied. First, the nonlinear observability is studied for when the leader robot observes landmarks. Second, the system is shown to be completely observable when the leader robot observes two different landmarks. When the leader robot system is observable, multi-robots can rapidly form and maintain a formation based on the bearing-only information that the follower robots observe from the leader robot. Finally, simulations confirm the effectiveness of the proposed formation control. PMID:28426706

  1. Controllable injector for local flux entry into superconducting films

    Energy Technology Data Exchange (ETDEWEB)

    Carmo, D.; Colauto, F.; de Andrade, A. M. H.; Oliveira, A. A. M.; Ortiz, W. A.; Johansen, T. H.

    2016-07-21

    A superconducting flux injector (SFI) has been designed to allow for controlled injections of magnetic flux into a superconducting film from a predefined location along the edge. The SFI is activated by an external current pulse, here chosen to be 200 ms long, and it is demonstrated on films of Nb that the amount of injected flux is controlled by the pulse height. Examples of injections at two different temperatures where the flux enters by stimulated flux-flow and by triggered thermomagnetic avalanches are presented. The boundary between the two types of injection is determined and discussed. The SFI opens up for active use of phenomena which up to now have been considered hazardous for a safe operation of superconducting devices.

  2. Local Gate Control of a Carbon Nanotube Double Quantum Dot

    Science.gov (United States)

    2016-04-04

    candidates for elu- cidating surface phenomena. Here, we used Car -Parrinello molecular dynamics (CPMD) (13, 14) to investigate the properties of the aqueous...This ability to control electron interactions in the quantum regime in a molecular conductor is important for applications such as quantum...fabricated in semiconductor heterostructures (21, 26). Such similarities suggest that more complex quantum devices formed from molecular conductors such as

  3. Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yun Seon; Park, Sung Kwang; Cho, Heung Lae; Ahn, Ki Jung [Dept. of Radiation Oncology, (Korea, Republic of); Lee, Yun Han [Dept. of Molecular Medicine, Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2016-06-15

    The association between metabolism and cancer has been recently emphasized. This study aimed to find the prognostic significance of obesity in advanced stage rectal cancer patients treated with surgery and radiotherapy (RT). We retrospectively reviewed the medical records of 111 patients who were treated with combined surgery and RT for clinical stage 2–3 (T3 or N+) rectal cancer between 2008 and 2014. The prognostic significance of obesity (body mass index [BMI] ≥25 kg/m{sup 2}) in local control was evaluated. The median follow-up was 31.2 months (range, 4.1 to 85.7 months). Twenty-five patients (22.5%) were classified as obese. Treatment failure occurred in 33 patients (29.7%), including local failures in 13 patients (11.7%), regional lymph node failures in 5, and distant metastases in 24. The 3-year local control, recurrence-free survival, and overall survival rates were 88.7%, 73.6%, and 87.7%, respectively. Obesity (n = 25) significantly reduced the local control rate (p = 0.045; 3-year local control, 76.2%), especially in women (n = 37, p = 0.021). Segregation of local control was best achieved by BMI of 25.6 kg/m{sup 2} as a cutoff value. Obese rectal cancer patients showed poor local control after combined surgery and RT. More effective local treatment strategies for obese patients are warranted.

  4. Controlling the local false discovery rate in the adaptive Lasso

    KAUST Repository

    Sampson, J. N.

    2013-04-09

    The Lasso shrinkage procedure achieved its popularity, in part, by its tendency to shrink estimated coefficients to zero, and its ability to serve as a variable selection procedure. Using data-adaptive weights, the adaptive Lasso modified the original procedure to increase the penalty terms for those variables estimated to be less important by ordinary least squares. Although this modified procedure attained the oracle properties, the resulting models tend to include a large number of "false positives" in practice. Here, we adapt the concept of local false discovery rates (lFDRs) so that it applies to the sequence, λn, of smoothing parameters for the adaptive Lasso. We define the lFDR for a given λn to be the probability that the variable added to the model by decreasing λn to λn-δ is not associated with the outcome, where δ is a small value. We derive the relationship between the lFDR and λn, show lFDR =1 for traditional smoothing parameters, and show how to select λn so as to achieve a desired lFDR. We compare the smoothing parameters chosen to achieve a specified lFDR and those chosen to achieve the oracle properties, as well as their resulting estimates for model coefficients, with both simulation and an example from a genetic study of prostate specific antigen.

  5. What controls the local time extent of flux transfer events?

    CERN Document Server

    Milan, S E; Carter, J A; Walach, M -T; Hubert, B

    2016-01-01

    Flux transfer events (FTEs) are the manifestation of bursty and/or patchy magnetic reconnection at the magnetopause. We compare two sequences of the ionospheric signatures of flux transfer events observed in global auroral imagery and coherent ionospheric radar measurements. Both sequences were observed during very similar seasonal and interplanetary magnetic field (IMF) conditions, though with differing solar wind speed. A key observation is that the signatures differed considerably in their local time extent. The two periods are 26 August 1998, when the IMF had components $\\mathit{B}_{\\mathit{z}}$ $\\approx$ -10 nT and $\\mathit{B}_{\\mathit{y}}$ $\\approx$ 9 nT and the solar wind speed was $\\mathit{V}_{\\mathit{x}}$ $\\approx$ 650 km $s^{-1}$, and 31 August 2005, IMF $\\mathit{B}_{\\mathit{z}}$ $\\approx$ -7 nT, $\\mathit{B}_{\\mathit{y}}$ $\\approx$ 17 nT, and $\\mathit{V}_{\\mathit{x}}$ $\\approx$ 380 km $s^{-1}$. In the first case, the reconnection rate was estimated to be near 160 kV, and the FTE signatures extended ...

  6. Leadership Can Create Excellence.

    Science.gov (United States)

    Terrey, John N.

    Current writers on the topic of educational leadership express essentially the same concerns: the absence of leadership and vision, the tendency to select survivalism over risk, and the control by managers rather than leaders. These writers highlight both the craving and the need for leadership. Several recent publications provide insights into…

  7. Precise Localization and Formation Control of Swarm Robots via Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Han Wu

    2014-01-01

    Full Text Available Precise localization and formation control are one of the key technologies to achieve coordination and control of swarm robots, which is also currently a bottleneck for practical applications of swarm robotic systems. Aiming at overcoming the limited individual perception and the difficulty of achieving precise localization and formation, a localization approach combining dead reckoning (DR with wireless sensor network- (WSN- based methods is proposed in this paper. Two kinds of WSN localization technologies are adopted in this paper, that is, ZigBee-based RSSI (received signal strength indication global localization and electronic tag floors for calibration of local positioning. First, the DR localization information is combined with the ZigBee-based RSSI position information using the Kalman filter method to achieve precise global localization and maintain the robot formation. Then the electronic tag floors provide the robots with their precise coordinates in some local areas and enable the robot swarm to calibrate its formation by reducing the accumulated position errors. Hence, the overall performance of localization and formation control of the swarm robotic system is improved. Both of the simulation results and the experimental results on a real schematic system are given to demonstrate the success of the proposed approach.

  8. Inducible control of subcellular RNA localization using a synthetic protein-RNA aptamer interaction.

    Directory of Open Access Journals (Sweden)

    Brian J Belmont

    Full Text Available Evidence is accumulating in support of the functional importance of subcellular RNA localization in diverse biological contexts. In different cell types, distinct RNA localization patterns are frequently observed, and the available data indicate that this is achieved through a series of highly coordinated events. Classically, cis-elements within the RNA to be localized are recognized by RNA-binding proteins (RBPs, which then direct specific localization of a target RNA. Until now, the precise control of the spatiotemporal parameters inherent to regulating RNA localization has not been experimentally possible. Here, we demonstrate the development and use of a chemically-inducible RNA-protein interaction to regulate subcellular RNA localization. Our system is composed primarily of two parts: (i the Tet Repressor protein (TetR genetically fused to proteins natively involved in localizing endogenous transcripts; and (ii a target transcript containing genetically encoded TetR-binding RNA aptamers. TetR-fusion protein binding to the target RNA and subsequent localization of the latter are directly regulated by doxycycline. Using this platform, we demonstrate that enhanced and controlled subcellular localization of engineered transcripts are achievable. We also analyze rules for forward engineering this RNA localization system in an effort to facilitate its straightforward application to studying RNA localization more generally.

  9. Controlled Release System for Localized and Sustained Drug Delivery Applications

    Science.gov (United States)

    Rodriguez, Lidia Betsabe

    Current controlled release formulations has many drawbacks such as excess of initial burst release, low drug efficiency, non-degradability of the system and low reproducibility. The present project aims to offer an alternative by developing a technique to prepare uniform, biodegradable particles ( ˜19 mum ) that can sustainably release a drug for a specific period of time. Chitosan is a natural polysaccharide that has many characteristics to be used for biomedical applications. In the last two decades, there have been a considerable number of studies affirming that chitosan could be used for pharmaceutical applications. However, chitosan suffers from inherent weaknesses such as low mechanical stability and dissolution of the system in acidic media. In the present study, chitosan microparticles were prepared by emulsification process. The model drug chosen was acetylsalicylic acid as it is a small and challenging molecule. The maximum loading capacity obtained for the microparticles was approximately 96%. The parameters for the preparation of uniform particles with a narrow size distribution were identified in a triangular phase diagram. Moreover, chitosan particles were successfully coated with thin layers of poly lactic-coglycolic acid (PLGA) and poly lactic acid (PLA). The performance of different layerswas tested for in vitro drug release and degradation studies. Additionally, the degradability of the system was evaluated by measuring the weight loss of the system when exposed to enzyme and without enzyme. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM) and inductively coupled plasma optical emission spectrometry (ICP-OES) were used to characterize the controlled release system. Additionally, the in vitro drug release was monitored by ultraviolet-visible spectrophotometry (UV-Vis) and liquid chromatography mass spectrometry (LC-MS). The results obtained from this project showed that it is

  10. Computer-controlled local anesthetic delivery for painless anesthesia: a literature review.

    Science.gov (United States)

    Kwak, Eun-Jung; Pang, Nan-Sim; Cho, Jin-Hyung; Jung, Bock-Young; Kim, Kee-Deog; Park, Wonse

    2016-06-01

    Local anesthesia is administered to reduce pain during dental treatments, but may itself cause pain and contribute to increased dental fear. Computer-controlled local anesthetic delivery (CCLAD) is one the method to reduce patient pain during local anesthesia; it is a device that slowly administers anesthetics by using a computerized device to control the injection speed. This literature review aims to provide an objective assessment of the usefulness of CCLAD for controlling pain by reviewing papers published to date that have used CCLAD.

  11. Computer-controlled local anesthetic delivery for painless anesthesia: a literature review

    Science.gov (United States)

    Kwak, Eun-Jung; Pang, Nan-Sim; Cho, Jin-Hyung; Jung, Bock-Young; Kim, Kee-Deog

    2016-01-01

    Local anesthesia is administered to reduce pain during dental treatments, but may itself cause pain and contribute to increased dental fear. Computer-controlled local anesthetic delivery (CCLAD) is one the method to reduce patient pain during local anesthesia; it is a device that slowly administers anesthetics by using a computerized device to control the injection speed. This literature review aims to provide an objective assessment of the usefulness of CCLAD for controlling pain by reviewing papers published to date that have used CCLAD. PMID:28879299

  12. Multi-region fuzzy logic controller with local PID controllers for U-tube steam generator in nuclear power plant

    Directory of Open Access Journals (Sweden)

    Puchalski Bartosz

    2015-12-01

    Full Text Available In the paper, analysis of multi-region fuzzy logic controller with local PID controllers for steam generator of pressurized water reactor (PWR working in wide range of thermal power changes is presented. The U-tube steam generator has a nonlinear dynamics depending on thermal power transferred from coolant of the primary loop of the PWR plant. Control of water level in the steam generator conducted by a traditional PID controller which is designed for nominal power level of the nuclear reactor operates insufficiently well in wide range of operational conditions, especially at the low thermal power level. Thus the steam generator is often controlled manually by operators. Incorrect water level in the steam generator may lead to accidental shutdown of the nuclear reactor and consequently financial losses. In the paper a comparison of proposed multi region fuzzy logic controller and traditional PID controllers designed only for nominal condition is presented. The gains of the local PID controllers have been derived by solving appropriate optimization tasks with the cost function in a form of integrated squared error (ISE criterion. In both cases, a model of steam generator which is readily available in literature was used for control algorithms synthesis purposes. The proposed multi-region fuzzy logic controller and traditional PID controller were subjected to broad-based simulation tests in rapid prototyping software - Matlab/Simulink. These tests proved the advantage of multi-region fuzzy logic controller with local PID controllers over its traditional counterpart.

  13. Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression

    NARCIS (Netherlands)

    Rades, Dirk; Fehlauer, Fabian; Schulte, Rainer; Veninga, Theo; Stalpers, Lukas J. A.; Basic, Hiba; Bajrovic, Amira; Hoskin, Peter J.; Tribius, Silke; Wildfang, Ingeborg; Rudat, Volker; Engenhart-Cabilic, Rita; Karstens, Johann H.; Alberti, Winfried; Dunst, Juergen; Schild, Steven E.

    2006-01-01

    To evaluate potential prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression (MSCC). The following potential prognostic factors were investigated retrospectively in 1,852 patients irradiated for MSCC: age, sex, performance status, primary tumor,

  14. Phase diagram for one-way traffic flow with local control

    Science.gov (United States)

    Lykov, A. A.; Malyshev, V. A.; Melikian, M. V.

    2017-11-01

    We consider one-way road deterministic traffic model with N particles. The simplest local control protocol, which reminds physical interaction is considered. We obtain complete phase diagram uniformly in N and study in detail its stable and unstable domains.

  15. MR imaging predictors of local control of glottic squamous cell carcinoma treated with radiation alone

    NARCIS (Netherlands)

    Ljumanovic, Redina; Langendijk, Johannes A.; van Wattingen, Menno; Schenk, Barry; Knol, Dirk L.; Leemans, C. Rene; Castelijns, Jonas A.

    Purpose: To retrospectively evaluate the prognostic significance of magnetic resonance ( MR) imaging - determined tumor parameters, especially the presence of cartilage invasion, regarding local control of glottic squamous cell carcinoma treated with radiation therapy ( RT) alone. Materials and

  16. The efficacy of control environment as fraud deterrence in local government

    National Research Council Canada - National Science Library

    Dian Anita Nuswantara; Ach Maulidi; Pujiono

    2017-01-01

    ... a contingency theory for the public sector. Within local government, contingency theory has emerged as a lens for exploring the links between public sector initiatives to improve risk mitigation and the structure of the control system...

  17. Local Measurement of Fuel Energy Deposition and Heat Transfer Environment During Fuel Lifetime Using Controlled Calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Don W. Miller; Andrew Kauffmann; Eric Kreidler; Dongxu Li; Hanying Liu; Daniel Mills; Thomas D. Radcliff; Joseph Talnagi

    2001-12-31

    A comprehensive description of the accomplishments of the DOE grant titled, ''Local Measurement of Fuel Energy Deposition and Heat Transfer Environment During Fuel Lifetime using Controlled Calorimetry''.

  18. Turbulence control with local pacing and its implication in cardiac defibrillation

    Science.gov (United States)

    Cao, Zhoujian; Li, Pengfei; Zhang, Hong; Xie, Fagen; Hu, Gang

    2007-03-01

    In this review article, we describe turbulence control in excitable systems by using a local periodic pacing method. The controllability conditions of turbulence suppression and the mechanisms underlying these conditions are analyzed. The local pacing method is applied to control Winfree turbulence (WT) and defect turbulence (DT) induced by spiral-wave breakup. It is shown that WT can always be suppressed by local pacing if the pacing amplitude and frequency are properly chosen. On the other hand, the pacing method can achieve suppression of DT induced by instabilities associated with the motions of spiral tips while failing to suppress DT induced by the instabilities of wave propagation far from tips. In the latter case, an auxiliary method of applying gradient field is suggested to improve the control effects. The implication of this local pacing method to realistic cardiac defibrillation is addressed.

  19. Excel VBA 24-hour trainer

    CERN Document Server

    Urtis, Tom

    2015-01-01

    Master VBA automation quickly and easily to get more out of Excel Excel VBA 24-Hour Trainer, 2nd Edition is the quick-start guide to getting more out of Excel, using Visual Basic for Applications. This unique book/video package has been updated with fifteen new advanced video lessons, providing a total of eleven hours of video training and 45 total lessons to teach you the basics and beyond. This self-paced tutorial explains Excel VBA from the ground up, demonstrating with each advancing lesson how you can increase your productivity. Clear, concise, step-by-step instructions are combined wit

  20. Excel data analysis for dummies

    CERN Document Server

    Nelson, Stephen L

    2014-01-01

    Harness the power of Excel to discover what your numbers are hiding Excel Data Analysis For Dummies, 2nd Edition is the ultimate guide to getting the most out of your data. Veteran Dummies author Stephen L. Nelson guides you through the basic and not-so-basic features of Excel to help you discover the gems hidden in your rough data. From input, to analysis, to visualization, the book walks you through the steps that lead to superior data analysis. Excel is the number-one spreadsheet application, with ever-expanding capabilities. If you're only using it to balance the books, you're missing out

  1. His Excellency Mr Farukh Amil

    CERN Multimedia

    hugho, Chemli

    2017-01-01

    His Excellency Mr Farukh Amil Ambassador Extraordinary and Plenipotentiary Permanent Representative of the Islamic Republic of Pakistan to the United Nations Office and other international organisations in Geneva

  2. Teaching physics using Microsoft Excel

    Science.gov (United States)

    Uddin, Zaheer; Ahsanuddin, Muhammad; Khan, Danish Ahmed

    2017-09-01

    Excel is both ubiquitous and easily understandable. Most people from every walk of life know how to use MS office and Excel spreadsheets. Students are also familiar with spreadsheets. Most students know how to use spreadsheets for data analysis. Besides basic use of Excel, some important aspects of spreadsheets are highlighted in this article. MS Excel can be used to visualize effects of various parameters in a physical system. It can be used as a simulating tool; simulation of wind data has been done through spreadsheets in this study. Examples of Lissajous figures and a damped harmonic oscillator are presented in this article.

  3. Learn Excel 2011 for Mac

    CERN Document Server

    Hart-Davis, Guy

    2011-01-01

    Microsoft Excel 2011 for Mac OS X is a powerful application, but many of its most impressive features can be difficult to find. Learn Excel 2011 for Mac by Guy Hart-Davis is a practical, hands-on approach to learning all of the details of Excel 2011 in order to get work done efficiently on Mac OS X. From using formulas and functions to creating databases, from analyzing data to automating tasks, you'll learn everything you need to know to put this powerful application to use for a variety of tasks. What you'll learn * The secrets of the Excel for Mac interface! * How to create effective workbo

  4. Olivocochlear Efferent Control in Sound Localization and Experience-Dependent Learning

    Science.gov (United States)

    Irving, Samuel; Moore, David R.; Liberman, M. Charles; Sumner, Christian J.

    2012-01-01

    Efferent auditory pathways have been implicated in sound localization and its plasticity. We examined the role of the olivocochlear system (OC) in horizontal sound localization by the ferret and in localization learning following unilateral earplugging. Under anesthesia, adult ferrets underwent olivocochlear bundle section at the floor of the fourth ventricle, either at the midline or laterally (left). Lesioned and control animals were trained to localize 1 s and 40ms amplitude-roved broadband noise stimuli from one of 12 loudspeakers. Neither type of lesion affected normal localization accuracy. All ferrets then received a left earplug and were tested and trained over 10 d. The plug profoundly disrupted localization. Ferrets in the control and lateral lesion groups improved significantly during subsequent training on the 1 s stimulus. No improvement (learning) occurred in the midline lesion group. Markedly poorer performance and failure to learn was observed with the 40 ms stimulus in all groups. Plug removal resulted in a rapid resumption of normal localization in all animals. Insertion of a subsequent plug in the right ear produced similar results to left earplugging. Learning in the lateral lesion group was independent of the side of the lesion relative to the earplug. Lesions in all reported cases were verified histologically. The results suggest the OC system is not needed for accurate localization, but that it is involved in relearning localization during unilateral conductive hearing loss. PMID:21325517

  5. Injection of sup 32 P colloid into squamous cell carcinoma of the esophagus for local disease control

    Energy Technology Data Exchange (ETDEWEB)

    Perakos, P.G.; Scheer, T.F. (Memorial Hospital of Laramie County and Wyoming College of Human Medicine, Wyoming (USA))

    1989-10-01

    Local treatment of squamous cell carcinoma of the esophagus is only modestly successful. To increase local control, we have developed a procedure to inject a boost dose of radiation into the tumor bed after completion of external beam radiotherapy. The boost dose is given with {sup 32}P, a readily available radiocolloid. {sup 32}P is a pure emitter and poses no significant radiation hazards. It can penetrate 10approx15 mm into the tumor mass and has a half-life of 14.3 days. After determination of the volume to be treated, the colloid is injected with endoscopic guidance using the same technique as used in injection scierotherapy of esophageal varices. We use the Pentax FG 34 JA operating gastroscope and a Bard disposable 0.5 cm 25 Ga retractable injection sclerotherapy needle. We deliver 150approx200 microCurie of {sup 32}P colloid diluted to 20 ml with normal saline at 10 to 20 injection sites. This boosts the radiotherapy dose of 5,500approx6,000 cGy to the range of 7,500approx8,000 cGy. We have treated five patients so far, with length of follow-up ranging from 8approx28 months. Local control and survival results have been excellent and no complications have been associated with the procedure. A combination of external beam radiotherapy and interstitial boost treatment with colloidal {sup 32}P appears to be a safe and effective method of managing squamous cell carcinoma of the esophagus. (author).

  6. Preliminary experience in treatment of papillary and macular retinoblastoma: evaluation of local control and local complications after treatment with linear accelerator-based stereotactic radiotherapy with micromultileaf collimator as second-line or salvage treatment after chemotherapy.

    Science.gov (United States)

    Pica, Alessia; Moeckli, Raphael; Balmer, Aubin; Beck-Popovic, Maja; Chollet-Rivier, Madeleine; Do, Huu-Phuoc; Weber, Damien C; Munier, Francis L

    2011-12-01

    To determine the local control and complication rates for children with papillary and/or macular retinoblastoma progressing after chemotherapy and undergoing stereotactic radiotherapy (SRT) with a micromultileaf collimator. Between 2004 and 2008, 11 children (15 eyes) with macular and/or papillary retinoblastoma were treated with SRT. The mean age was 19 months (range, 2-111). Of the 15 eyes, 7, 6, and 2 were classified as International Classification of Intraocular Retinoblastoma Group B, C, and E, respectively. The delivered dose of SRT was 50.4 Gy in 28 fractions using a dedicated micromultileaf collimator linear accelerator. The median follow-up was 20 months (range, 13-39). Local control was achieved in 13 eyes (87%). The actuarial 1- and 2-year local control rates were both 82%. SRT was well tolerated. Late adverse events were reported in 4 patients. Of the 4 patients, 2 had developed focal microangiopathy 20 months after SRT; 1 had developed a transient recurrence of retinal detachment; and 1 had developed bilateral cataracts. No optic neuropathy was observed. Linear accelerator-based SRT for papillary and/or macular retinoblastoma in children resulted in excellent tumor control rates with acceptable toxicity. Additional research regarding SRT and its intrinsic organ-at-risk sparing capability is justified in the framework of prospective trials. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Pica, Alessia, E-mail: Alessia.Pica@chuv.ch [Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland); Moeckli, Raphael [University Institute for Radiation Physics, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland); Balmer, Aubin [Department of Radiation Oncology, Jules Gonin Eye Hospital, Lausanne (Switzerland); Beck-Popovic, Maja [Unit of Pediatric Oncology, University of Lausanne, Lausanne (Switzerland); Chollet-Rivier, Madeleine [Department of Anesthesiology, University of Lausanne, Lausanne (Switzerland); Do, Huu-Phuoc [University Institute for Radiation Physics, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland); Weber, Damien C. [Department of Radiation Oncology, Geneva University Hospital, University of Geneva, Geneva (Switzerland); Munier, Francis L. [Department of Radiation Oncology, Jules Gonin Eye Hospital, Lausanne (Switzerland)

    2011-12-01

    Purpose: To determine the local control and complication rates for children with papillary and/or macular retinoblastoma progressing after chemotherapy and undergoing stereotactic radiotherapy (SRT) with a micromultileaf collimator. Methods and Materials: Between 2004 and 2008, 11 children (15 eyes) with macular and/or papillary retinoblastoma were treated with SRT. The mean age was 19 months (range, 2-111). Of the 15 eyes, 7, 6, and 2 were classified as International Classification of Intraocular Retinoblastoma Group B, C, and E, respectively. The delivered dose of SRT was 50.4 Gy in 28 fractions using a dedicated micromultileaf collimator linear accelerator. Results: The median follow-up was 20 months (range, 13-39). Local control was achieved in 13 eyes (87%). The actuarial 1- and 2-year local control rates were both 82%. SRT was well tolerated. Late adverse events were reported in 4 patients. Of the 4 patients, 2 had developed focal microangiopathy 20 months after SRT; 1 had developed a transient recurrence of retinal detachment; and 1 had developed bilateral cataracts. No optic neuropathy was observed. Conclusions: Linear accelerator-based SRT for papillary and/or macular retinoblastoma in children resulted in excellent tumor control rates with acceptable toxicity. Additional research regarding SRT and its intrinsic organ-at-risk sparing capability is justified in the framework of prospective trials.

  8. Excellent adherence and no contamination by physiotherapists involved in a randomized controlled trial on reactivation of COPD patients: a qualitative process evaluation study

    NARCIS (Netherlands)

    Effing, T.W.; Krabbenbos, M.; Pieterse, Marcel E.; van der Valk, P.; Zielhuis, G.A.; Kerstjens, H.A.M.; van der Palen, J.; van der Palen, J.

    2012-01-01

    Objective: To assess the adherence of physiotherapists to the study protocol and the occurrence of contamination bias during the course of a randomized controlled trial with a recruitment period of 2 years and a 1-year follow-up (COPE-II study). Study design and setting: In the COPE-II study,

  9. Excellent adherence and no contamination by physiotherapists involved in a randomized controlled trial on reactivation of COPD patients : a qualitative process evaluation study

    NARCIS (Netherlands)

    Effing, Tanja W.; Krabbenbos, Manon; Pieterse, Marcel E.; van der Valk, Paul D. L. P. M.; Zielhuis, Gerhard A.; Kerstjens, Huib A. M.; van der Palen, Job

    2012-01-01

    Objective: To assess the adherence of physiotherapists to the study protocol and the occurrence of contamination bias during the course of a randomized controlled trial with a recruitment period of 2 years and a 1-year follow-up (COPE-II study). Study design and setting: In the COPE-II study,

  10. ARS-Media for Excel

    Science.gov (United States)

    ARS-Media for Excel is an ion solution calculator that uses Microsoft Excel to generate recipes of salts for complex ion mixtures specified by the user. Generating salt combinations (recipes) that result in pre-specified target ion values is a linear programming problem. Thus, the recipes are genera...

  11. Excellent adherence and no contamination by physiotherapists involved in a randomized controlled trial on reactivation of COPD patients: a qualitative process evaluation study

    Directory of Open Access Journals (Sweden)

    Effing TW

    2012-05-01

    Full Text Available Tanja W Effing,1,2 Manon Krabbenbos,3 Marcel E Pieterse,4 Paul DLPM van der Valk,3 Gerhard A Zielhuis,5 Huib AM Kerstjens,6 Job van der Palen,371Repatriation General Hospital, Department of Respiratory Medicine, Daw Park, 2Flinders University, School of Medicine, Adelaide, South Australia, Australia; 3Medisch Spectrum Twente, Department of Pulmonology, Enschede, 4Department of Psychology, Health and Technology, Enschede, 5Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen, Nijmegen, 6Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, 7Department of Research Methodology, Measurement and Data Analysis, University of Twente, The Netherlands Objective: To assess the adherence of physiotherapists to the study protocol and the occurrence of contamination bias during the course of a randomized controlled trial with a recruitment period of 2 years and a 1-year follow-up (COPE-II study.Study design and setting: In the COPE-II study, intervention patients received a standardized physiotherapeutic reactivation intervention (COPE-active and control patients received usual care. The latter could include regular physiotherapy treatment. Information about the adherence of physiotherapists with the study protocol was collected by performing a single interview with both intervention and control patients. Patients were only interviewed when they were currently receiving physiotherapy. Interviews were performed during two separate time periods, 10 months apart. Nine characteristics of the COPE-active intervention were scored. Scores were converted into percentages (0%, no aspects of COPE-active; 100%, full implementation of COPE-active.Results: Fifty-one patients were interviewed (first period: intervention n = 14 and control n = 10; second period: intervention n = 18 and control n = 9. Adherence with the COPE-active protocol was high (median scores: period 1, 96.8%; period 2, 92.1%, and

  12. Negative impact of pretreatment anemia on local control after neoadjuvant chemoradiotherapy and surgery for rectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hye Bin; Park, Hee Chul; Park, Won [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); and others

    2012-09-15

    Although anemia is considered to be a contributor to intra-tumoral hypoxia and tumor resistance to ionizing radiation in cancer patients, the impact of pretreatment anemia on local control after neoadjuvant concurrent chemoradiotherapy (NACRT) and surgery for rectal cancer remains unclear. We reviewed the records of 247 patients with locally advanced rectal cancer who were treated with NACRT followed by curative-intent surgery. The patients with anemia before NACRT (36.0%, 89/247) achieved less pathologic complete response (pCR) than those without anemia (p = 0.012). The patients with pretreatment anemia had worse 3-year local control than those without pretreatment anemia (86.0% vs. 95.7%, p = 0.005). Multivariate analysis showed that pretreatment anemia (p = 0.035), pathologic tumor and nodal stage (p = 0.020 and 0.032, respectively) were independently significant factors for local control. Pretreatment anemia had negative impacts on pCR and local control among patients who underwent NACRT and surgery for rectal cancer. Strategies maintaining hemoglobin level within normal range could potentially be used to improve local control in rectal cancer patients.

  13. A Local Controller for Discrete-Time Large-Scale System by Using Integral Variable Structure Control

    Directory of Open Access Journals (Sweden)

    C. H. Chai

    2015-01-01

    Full Text Available A new local controller for discrete-time integral variable structure control of a large-scale system with matched and unmatched uncertainty is presented. The local controller is able to bring the large-scale system into stability by using only the states feedback from individual subsystem itself. A new theorem is established and proved that the controller is able to handle the effect of interconnection for the large-scale system with matched and unmatched uncertainty, and the system stability is ensured. The controller is able to control the system to achieve the quasi-sliding surface and remains on it. The results showed a fast convergence to the desired value and the attenuation of disturbance is achieved.

  14. Brewer, Maine Wastewater Treatment Plant Recognized for Excellence

    Science.gov (United States)

    The Brewer Water Pollution Control Facility was recently honored with a 2015 Regional Wastewater Treatment Plant Excellence Award by the US Environmental Protection Agency's New England regional office.

  15. The influence of diabetic peripheral neuropathy on local postural muscle and central sensory feedback balance control.

    Science.gov (United States)

    Toosizadeh, Nima; Mohler, Jane; Armstrong, David G; Talal, Talal K; Najafi, Bijan

    2015-01-01

    Poor balance control and increased fall risk have been reported in people with diabetic peripheral neuropathy (DPN). Traditional body sway measures are unable to describe underlying postural control mechanism. In the current study, we used stabilogram diffusion analysis to examine the mechanism under which balance is altered in DPN patients under local-control (postural muscle control) and central-control (postural control using sensory cueing). DPN patients and healthy age-matched adults over 55 years performed two 15-second Romberg balance trials. Center of gravity sway was measured using a motion tracker system based on wearable inertial sensors, and used to derive body sway and local/central control balance parameters. Eighteen DPN patients (age = 65.4±7.6 years; BMI = 29.3±5.3 kg/m2) and 18 age-matched healthy controls (age = 69.8±2.9; BMI = 27.0±4.1 kg/m2) with no major mobility disorder were recruited. The rate of sway within local-control was significantly higher in the DPN group by 49% (healthy local-controlslope = 1.23±1.06×10-2 cm2/sec, Pcontrol balance behavior in DPN patients. Unlike local-control, the rate of sway within central-control was 60% smaller in the DPN group (healthy central-controlslope-Log = 0.39±0.23, Pcontrol rate of sway with neuropathy severity (rPearson = 0.65-085, Pdiabetes (rPearson = 0.58-071, Pcontrols. However, as soon as they perceived the magnitude of sway using sensory feedback, they chose a high rigid postural control strategy, probably due to high concerns for fall, which may increase the energy cost during extended period of standing; the adaptation mechanism using sensory feedback depends on the level of neuropathy and the history of diabetes.

  16. Local knowledge, science, and institutional change: the case of desertification control in Northern China.

    Science.gov (United States)

    Yang, Lihua

    2015-03-01

    This article studies the influence of local knowledge on the impact of science on institutional change in ecological and environmental management. Based on an empirical study on desertification control in 12 counties in north China, the study found the following major results: (1) although there was a cubic relationship between the extent and effect of local knowledge, local knowledge significantly influenced the impact of science on institutional change; (2) local knowledge took effect mainly through affecting formal laws and regulations, major actors, and methods of desertification control in institutional change but had no significant impact on the types of property rights; and (3) local knowledge enhanced the impact of science on the results of desertification control through affecting the impact of science on institutional change. These findings provide a reference for researchers, policy makers, and practitioners, both in China and in other regions of the world, to further explore the influence of local knowledge on the impact of science on institutional change and the roles of local knowledge or knowledge in institutional change and governance.

  17. Local distributed estimation. [for flexible spacecraft vibration mode optimal feedback control

    Science.gov (United States)

    Schaechter, D. B.

    1980-01-01

    Based on partial differential equations of motion the closed form solution for the optimal estimation of a spatially continuous state vector is derived, using a continuously distributed sensor. Local control is shown to be the feedback that minimizes a quadratic performance index of sensor and process disturbances. A detailed example of the control of a string in tension is presented.

  18. Local Adaptive Control of Solar Photovoltaics and Electric Water Heaters for Real-time Grid Support

    DEFF Research Database (Denmark)

    Bhattarai, Bishnu Prasad; Mendaza, Iker Diaz de Cerio; Bak-Jensen, Birgitte

    2016-01-01

    , such as electric vehicles, electric water heaters (EWHs) etc. An adaptive control using only local measurements for the EWHs and PVs is proposed in this study to alleviate OV as well as UV issues. The adaptive control is designed such that it monitors the voltage at the point of connection and adjusts active...

  19. Organization of nosocomial infection control measures and local networks for infectious disease control in middle-scale hospitals in Japan.

    Science.gov (United States)

    Mori-Yoshikawa, Namiko; Ohmagari, Norio; Kirikae, Teruo

    2014-01-01

    The aims of this study were to assess nosocomial infection control measures at middle-scale hospitals throughout Japan. Of the 823 hospitals participating in this questionnaire-based survey, more than half of the middle-scale hospitals have implemented nosocomial infection control measures, including infection surveillance or infection control rounds, while acknowledging a shortage of infection control staff. These hospitals most frequently consulted public health centers to obtain information and advice. Improved nosocomial infection control in middle-scale hospitals requires sufficient staffing and a local network, with active participation by public health centers.

  20. Explaining variation in gun control policy advocacy tactics among local organizations.

    Science.gov (United States)

    Zakocs, Ronda C; Earp, Jo Anne L

    2003-06-01

    The goal of this study was to determine how well four organizational characteristics (structure, resources, motivation, or political capacity) explained local organizations' use of a variety of advocacy tactics aimed at promoting state gun control laws. In 1998, 679 local organizations were identified as potentially active on state gun control issues; a questionnaire was mailed to each group's leader. Seventy-nine percent (n = 538) responded to the survey, with 81% (n = 207) of eligible organizations completing questionnaires. The four organizational characteristics explained approximately half the variation in local groups' use of a wide range of advocacy tactics. Organizations with stronger motivation to address the gun control issue and greater political capacity engaged in more diverse gun control advocacy tactics; the authors found organizational structure and resources unlikely to be related. Leaders of advocacy organizations should consider ways to encourage members' motivations on the issue while fostering greater capacity for political action.

  1. Highly concentrated polycations-functionalized graphene nanosheets with excellent solubility and stability, and its fast, facile and controllable assembly of multiple nanoparticles

    Science.gov (United States)

    Lv, Zhaozi; Yang, Xuan; Wang, Erkang

    2012-12-01

    Here we report that branch poly(ethylenimine) (BPEI) could be used as both a stabilizer and a reducing agent in the preparation of long-term stable polycations-functionalized graphene nanosheets (GNs) suspension with concentration as high as 5 mg mL-1. UV-vis spectroscopy, Fourier transform infrared, X-ray photo-electron spectroscopy, atomic force microscopy, transmission electron microscopy, Raman spectroscopy and X-ray diffraction were used to characterize the reduction process, composition and structure of BPEI functionalized GNs (BGNs). Fourier transform infrared and X-ray photo-electron spectroscopy data revealed that the BPEI was attached to the surface of GNs through covalent bonds such as amide bond and -Ar-NH-C bond, and could prevent their aggregation through strong electrostatic repulsion. From the atomic force microscopy image and height profile of BGNs, the modality of functionalized surface of BGNs should be continuous and compact. The as-obtained BGNs could disperse well not only in water but also in other alkaline solution, salt solution and organic solvents. The as-obtained BGNs containing abundant amino groups were used as effective and controllable templates for fast and facile assembly with a series of negatively charged nanoparticles (NPs), which was probably caused by the strong electrostatic interaction between both components. This paper presents a fast, facile, controllable, efficient and green approach for preparing GNs and GNs/NPs composites of great value for applications in various fields.Here we report that branch poly(ethylenimine) (BPEI) could be used as both a stabilizer and a reducing agent in the preparation of long-term stable polycations-functionalized graphene nanosheets (GNs) suspension with concentration as high as 5 mg mL-1. UV-vis spectroscopy, Fourier transform infrared, X-ray photo-electron spectroscopy, atomic force microscopy, transmission electron microscopy, Raman spectroscopy and X-ray diffraction were used to

  2. Teach yourself visually complete Excel

    CERN Document Server

    McFedries, Paul

    2013-01-01

    Get the basics of Excel and then go beyond with this new instructional visual guide While many users need Excel just to create simple worksheets, many businesses and professionals rely on the advanced features of Excel to handle things like database creation and data analysis. Whatever project you have in mind, this visual guide takes you step by step through what each step should look like. Veteran author Paul McFedries first presents the basics and then gradually takes it further with his coverage of designing worksheets, collaborating between worksheets, working with visual data

  3. Use of Local Dynamic Electricity Prices for Indirect Control of DER Power Units

    DEFF Research Database (Denmark)

    Nørgård, Per Bromand; Isleifsson, Fridrik Rafn

    2013-01-01

    electricity prices for indirect control of active power. The local, dynamic electricity prices are realised as dynamic adjustments of the quasi-stationary global power price. The aims of the dynamic price adjustments are to prevent overloading of the grid, to reduce the grid power losses and to regulate...... the grid voltage. The algorithms generating the local prices are dynamically adjusted according to the actual realised responses to the dynamic prices. Results are presented from an adapted version of the control principle implemented and tested in DTUs experimental research power system, SYSLAB, including...... wind power, solar power, flexible load and electrical storage. The local power price generation is based on the actual Nord Pool DK2 Spot prices on hourly basis as the quasi-stationary global electricity price, and the local SYSLAB's power exchange with the national grid as basis for the dynamic price...

  4. High-Dose-Rate Brachytherapy Boost Effect on Local Tumor Control in Young Women With Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Guinot, Jose-Luis, E-mail: jguinot@fivo.org [Department of Radiation Oncology, Fundacion Instituto Valenciano de Oncologia, Valencia (Spain); Baixauli-Perez, Cristobal [Health Services Research Unit, Center for Public Health Research, Valencia (Spain); Soler, Pablo; Tortajada, Maria Isabel; Moreno, Araceli; Santos, Miguel Angel; Mut, Alejandro [Department of Radiation Oncology, Fundacion Instituto Valenciano de Oncologia, Valencia (Spain); Gozalbo, Francisco [Department of Pathology, Fundacion Instituto Valenciano de Oncologia, Valencia (Spain); Arribas, Leoncio [Department of Radiation Oncology, Fundacion Instituto Valenciano de Oncologia, Valencia (Spain)

    2015-01-01

    Purpose: To evaluate the local control rate and complications of a single fraction of high-dose-rate brachytherapy (HDR BT) boost in women aged 45 yeas and younger after breast-conserving therapy. Methods and Materials: Between 1999 and 2007, 167 patients between the ages of 26 and 45 years old (72 were 40 years old or younger), with stages T1 to T2 invasive breast cancer with disease-free margin status of at least 5 mm after breast-conserving surgery received 46 to 50 Gy whole-breast irradiation plus a 7-Gy HDR-BT boost (“fast boost”). An axillary dissection was performed in 72.5% of the patients and sentinel lymph node biopsy in 27.5%. A supraclavicular area was irradiated in 19% of the patients. Chemotherapy was used in 86% of the patients and hormone treatment in 77%. Clinical nodes were present in 18% and pathological nodes in 29%. The pathological stage was pT0: 5%, pTis: 3%, pT1: 69% and pT2: 23%. Intraductal component was present in 40% and 28% were G3. Results: At a median follow-up of 92 months, 9 patients relapsed on the margin of the implant, and 1 patient in another quadrant, resulting in a 10-year local relapse rate of 4.3% and a breast relapse rate of 4.9%, with breast preservation in 93.4%; no case of mastectomy due to poor cosmesis arose. Actuarial 5- and 10-year disease-free, cause-specific, and overall survival rates were 87.9% and 85.8%, and 92.1% and 88.4%, and 92.1% and 87.3%, respectively. In a univariate analysis, triple-negative cases and negative hormone receptors did worse, but in a multivariate analysis, only the last factor was significant for local and breast control. Asymptomatic fibrosis G2 was recorded in 3 cases, and there were no other late complications. Cosmetic results were good to excellent in 97% of cases. Conclusions: A single dose of 7 Gy using the fast-boost technique is well tolerated, with a low rate of late complications and improved local tumor control in women aged 45 and younger, compared to published data

  5. Tumor volume as a prognostic factor for local control and overall survival in advanced larynx cancer.

    Science.gov (United States)

    Timmermans, Adriana J; Lange, Charlotte A H; de Bois, Josien A; van Werkhoven, Erik; Hamming-Vrieze, Olga; Hilgers, Frans J M; van den Brekel, Michiel W M

    2016-02-01

    Tumor volume has been postulated to be an important prognostic factor for oncological outcome after radiotherapy or chemoradiotherapy. This postulate was retrospectively investigated in a consecutively treated cohort of T3-T4 larynx cancer patients. Retrospective cohort study. For 166 patients with T3-T4 larynx cancer (1999-2008), pretreatment computed tomography and magnetic resonance imaging scans were available for tumor volume delineation. Patients were treated with radiotherapy, chemoradiotherapy, or total laryngectomy with postoperative radiotherapy. Both a dedicated head and neck radiologist and the first author determined all tumor volumes. Statistical analysis was by Kaplan-Meier plots and Cox proportional hazard models. Patients with T3 larynx cancer had significantly smaller tumor volumes than patients with T4 larynx cancer (median = 8.1 cm(3) and 15.8 cm(3), respectively; P < .0001). In the group treated with total laryngectomy and postoperative radiotherapy, no association was found between tumor volume and local or locoregional control or overall survival. In the group treated with radiotherapy, a nonsignificant trend was observed between local control and tumor volume. In the chemoradiotherapy group, however, a significant impact of tumor volume was found on local control (hazard ratio = 1.07; 95% confidence interval = 1.01-1.13; P = .028). Tumor volume was not significantly associated with local control, locoregional control, or overall survival in the surgically treated group. In the group treated with radiotherapy, there was no statistically significant association, but a trend was observed between local control and tumor volume. Only in patients treated with concurrent chemoradiotherapy was a significant impact of tumor volume on local control found. 4. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

  6. Distributed model predictive control for constrained nonlinear systems with decoupled local dynamics.

    Science.gov (United States)

    Zhao, Meng; Ding, Baocang

    2015-03-01

    This paper considers the distributed model predictive control (MPC) of nonlinear large-scale systems with dynamically decoupled subsystems. According to the coupled state in the overall cost function of centralized MPC, the neighbors are confirmed and fixed for each subsystem, and the overall objective function is disassembled into each local optimization. In order to guarantee the closed-loop stability of distributed MPC algorithm, the overall compatibility constraint for centralized MPC algorithm is decomposed into each local controller. The communication between each subsystem and its neighbors is relatively low, only the current states before optimization and the optimized input variables after optimization are being transferred. For each local controller, the quasi-infinite horizon MPC algorithm is adopted, and the global closed-loop system is proven to be exponentially stable. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  7. ARS-Media for excel instruction manual

    Science.gov (United States)

    ARS-Media for Excel Instruction Manual is the instruction manual that explains how to use the Excel spreadsheet ARS-Media for Excel application. ARS-Media for Excel Instruction Manual is provided as a pdf file....

  8. A new strategy for transient stability using augmented generator control and local dynamic braking

    Energy Technology Data Exchange (ETDEWEB)

    Dorsey, J.; Jiang, H.; Habetler, T. [Georgia Inst. of Tech., Atlanta, GA (United States); Qu, Z. [University of Central Florida, Orlando, FL (United States)

    1994-12-31

    A decentralized automatic control strategy for significantly improving the transient stability of a large power system is introduced. The strategy combines local dynamic braking and a straightforward augmentation of the existing turbine / governor control system that uses only local feedback. The brake resistor, which employs thick film, metal oxide technology, has no inductance and is of very low resistance, allowing its use during fault to show a generator`s acceleration. Simulation results using the 39 Bus New England system show that the strategy dramatically increases the global stability of a power system. (author) 15 refs., 7 figs., 1 tab.

  9. Favorable Local Control From Consolidative Radiation Therapy in High-Risk Neuroblastoma Despite Gross Residual Disease, Positive Margins, or Nodal Involvement

    Energy Technology Data Exchange (ETDEWEB)

    Ferris, Matthew J., E-mail: mjferri@emory.edu [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Danish, Hasan [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Switchenko, Jeffrey M. [Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia (United States); Deng, Claudia [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); George, Bradley A.; Goldsmith, Kelly C.; Wasilewski, Karen J.; Cash, W. Thomas [Aflac Cancer and Blood Disorders Center, Children' s Healthcare of Atlanta, Atlanta, Georgia (United States); Khan, Mohammad K.; Eaton, Bree R.; Esiashvili, Natia [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)

    2017-03-15

    Purpose: To report the influence of radiation therapy (RT) dose and surgical pathology variables on disease control and overall survival (OS) in patients treated for high-risk neuroblastoma at a single institution. Methods and Materials: We conducted a retrospective study of 67 high-risk neuroblastoma patients who received RT as part of definitive management from January 2003 until May 2014. Results: At a median follow-up of 4.5 years, 26 patients (38.8%) failed distantly; 4 of these patients also failed locally. One patient progressed locally without distant failure. Local control was 92.5%, and total disease control was 59.5%. No benefit was demonstrated for RT doses over 21.6 Gy with respect to local relapse–free survival (P=.55), disease-free survival (P=.22), or OS (P=.72). With respect to local relapse–free survival, disease-free survival, and OS, no disadvantage was seen for positive lymph nodes on surgical pathology, positive surgical margins, or gross residual disease. Of the patients with gross residual disease, 75% (6 of 8) went on to have no evidence of disease at time of last follow-up, and the 2 patients who failed did so distantly. Conclusions: Patients with high-risk neuroblastoma in this series maintained excellent local control, with no benefit demonstrated for radiation doses over 21.6 Gy, and no disadvantage demonstrated for gross residual disease after surgery, positive surgical margins, or pathologic lymph node positivity. Though the limitations of a retrospective review for an uncommon disease must be kept in mind, with small numbers in some of the subgroups, it seems that dose escalation should be considered only in exceptional circumstances.

  10. Favorable Local Control From Consolidative Radiation Therapy in High-Risk Neuroblastoma Despite Gross Residual Disease, Positive Margins, or Nodal Involvement.

    Science.gov (United States)

    Ferris, Matthew J; Danish, Hasan; Switchenko, Jeffrey M; Deng, Claudia; George, Bradley A; Goldsmith, Kelly C; Wasilewski, Karen J; Cash, W Thomas; Khan, Mohammad K; Eaton, Bree R; Esiashvili, Natia

    2017-03-15

    To report the influence of radiation therapy (RT) dose and surgical pathology variables on disease control and overall survival (OS) in patients treated for high-risk neuroblastoma at a single institution. We conducted a retrospective study of 67 high-risk neuroblastoma patients who received RT as part of definitive management from January 2003 until May 2014. At a median follow-up of 4.5 years, 26 patients (38.8%) failed distantly; 4 of these patients also failed locally. One patient progressed locally without distant failure. Local control was 92.5%, and total disease control was 59.5%. No benefit was demonstrated for RT doses over 21.6 Gy with respect to local relapse-free survival (P=.55), disease-free survival (P=.22), or OS (P=.72). With respect to local relapse-free survival, disease-free survival, and OS, no disadvantage was seen for positive lymph nodes on surgical pathology, positive surgical margins, or gross residual disease. Of the patients with gross residual disease, 75% (6 of 8) went on to have no evidence of disease at time of last follow-up, and the 2 patients who failed did so distantly. Patients with high-risk neuroblastoma in this series maintained excellent local control, with no benefit demonstrated for radiation doses over 21.6 Gy, and no disadvantage demonstrated for gross residual disease after surgery, positive surgical margins, or pathologic lymph node positivity. Though the limitations of a retrospective review for an uncommon disease must be kept in mind, with small numbers in some of the subgroups, it seems that dose escalation should be considered only in exceptional circumstances. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Precise Localization and Control of Catalytic Janus Micromotors Using Weak Magnetic Fields

    Directory of Open Access Journals (Sweden)

    Islam S. M. Khalil

    2015-01-01

    Full Text Available We experimentally demonstrate the precise localization of spherical Pt-Silica Janus micromotors (diameter 5 μm under the influence of controlled magnetic fields. First, we control the motion of the Janus micromotors in two-dimensional (2D space. The control system achieves precise localization within an average region-of-convergence of 7 μm. Second, we show that these micromotors provide sufficient propulsion force, allowing them to overcome drag and gravitational forces and move both downwards and upwards. This propulsion is studied by moving the micromotors in three-dimensional (3D space. The micromotors move downwards and upwards at average speeds of 19.1 μm/s and 9.8 μm/s, respectively. Moreover, our closed-loop control system achieves localization in 3D space within an average region-of-convergence of 6.3 μm in diameter. The precise motion control and localization of the Janus micromotors in 2D and 3D spaces provides broad possibilities for nanotechnology applications.

  12. Autonomous Micro-Air-Vehicle Control Based on Visual Sensing for Odor Source Localization

    Directory of Open Access Journals (Sweden)

    Kenzo Kurotsuchi

    2017-07-01

    Full Text Available In this paper, we propose a novel control method for autonomous-odor-source localization using visual and odor sensing by micro air vehicles (MAVs. Our method is based on biomimetics, which enable highly autonomous localization. Our method does not need any instruction signals, including even global positioning system (GPS signals. An experimenter simply blows a whistle, and the MAV will then start to hover, to seek an odor source, and to keep hovering near the source. The GPS-signal-free control based on visual sense enables indoor/underground use. Moreover, the MAV is light-weight (85 grams and does not cause harm to others even if it accidentally falls. Experiments conducted in the real world were successful in enabling odor source localization using the MAV with a bio-inspired searching method. The distance error of the localization was 63 cm, more accurate than the target distance of 120 cm for individual identification. Our odor source localization is the first step to a proof of concept for a danger warning system. These localization experiments were the first step to a proof of concept for a danger warning system to enable a safer and more secure society.

  13. Indirect control of DSRs for regulating power provision and solving local congestions

    DEFF Research Database (Denmark)

    Sossan, Fabrizio; Marinelli, Mattia; Costanzo, Giuseppe Tommaso

    2013-01-01

    shows how using indirect control (or control by price) without any precautions, might easily lead to congestions in nearly saturated distribution grids. An auto tuning local controller which acts on the price signal at distribution level is proposed for solving the congestion. Simulations are performed...... with the CIGRE’ MV reference network with 346 electrically heated buildings as Demand Side Resources, DSRs. The dynamic hourly price of the regulating power provided by Nord Pool Spot market has been used as indirect control signal for the flexible demand....

  14. Localized and Energy-Efficient Topology Control in Wireless Sensor Networks Using Fuzzy-Logic Control Approaches

    Directory of Open Access Journals (Sweden)

    Yuanjiang Huang

    2014-01-01

    Full Text Available The sensor nodes in the Wireless Sensor Networks (WSNs are prone to failures due to many reasons, for example, running out of battery or harsh environment deployment; therefore, the WSNs are expected to be able to maintain network connectivity and tolerate certain amount of node failures. By applying fuzzy-logic approach to control the network topology, this paper aims at improving the network connectivity and fault-tolerant capability in response to node failures, while taking into account that the control approach has to be localized and energy efficient. Two fuzzy controllers are proposed in this paper: one is Learning-based Fuzzy-logic Topology Control (LFTC, of which the fuzzy controller is learnt from a training data set; another one is Rules-based Fuzzy-logic Topology Control (RFTC, of which the fuzzy controller is obtained through designing if-then rules and membership functions. Both LFTC and RFTC do not rely on location information, and they are localized. Comparing them with other three representative algorithms (LTRT, List-based, and NONE through extensive simulations, our two proposed fuzzy controllers have been proved to be very energy efficient to achieve desired node degree and improve the network connectivity when sensor nodes run out of battery or are subject to random attacks.

  15. Evaluation of secure capability-based access control in the M2M local cloud platform

    DEFF Research Database (Denmark)

    Anggorojati, Bayu; Prasad, Neeli R.; Prasad, Ramjee

    2016-01-01

    delegation. Recently, the capability based access control has been considered as method to manage access in the Internet of Things (IoT) or M2M domain. In this paper, the implementation and evaluation of a proposed secure capability based access control in the M2M local cloud platform is presented......Managing access to and protecting resources is one of the important aspect in managing security, especially in a distributed computing system such as Machine-to-Machine (M2M). One such platform known as the M2M local cloud platform, referring to BETaaS architecture [1], which conceptually consists...... of multiple distributed M2M gateways, creating new challenges in the access control. Some existing access control systems lack in scalability and flexibility to manage access from users or entity that belong to different authorization domains, or fails to provide fine grained and flexible access right...

  16. Transforming local government by project portfolio management: Identifying and overcoming control problems

    DEFF Research Database (Denmark)

    Hansen, Lars Kristian

    2013-01-01

    Purpose – As public organizations strive for higher e-government maturity, information technology (IT) Project Portfolio Management (IT PPM) has become a high priority issue. Assuming control is central in IT PPM, the purpose of this paper is to investigate how a Danish local government conducts...... workshop, and analyses of documents. Findings – It is found that the local government relies vastly on informal control mechanisms and five control problems are identified: weak accountability processes between the political and administrative level; weak accountability between the director level...... and the IT executives; IT projects established on the basis of incomplete information about internal resources; lack of operational goals to hold IT projects accountable; and no account of actual IT project costs. The authors propose a model for highlighting how more formal control can be implemented and address...

  17. Quantification of local and global benefits from air pollution control in Mexico City.

    Science.gov (United States)

    Mckinley, Galen; Zuk, Miriam; Höjer, Morten; Avalos, Montserrat; González, Isabel; Iniestra, Rodolfo; Laguna, Israel; Martínez, Miguel A; Osnaya, Patricia; Reynales, Luz M; Valdés, Raydel; Martínez, Julia

    2005-04-01

    Complex sociopolitical, economic, and geographical realities cause the 20 million residents of Mexico City to suffer from some of the worst air pollution conditions in the world. Greenhouse gas emissions from the city are also substantial, and opportunities for joint local-global air pollution control are being sought. Although a plethora of measures to improve local air quality and reduce greenhouse gas emissions have been proposed for Mexico City, resources are not available for implementation of all proposed controls and thus prioritization must occur. Yet policy makers often do not conduct comprehensive quantitative analyses to inform these decisions. We reanalyze a subset of currently proposed control measures, and derive cost and health benefit estimates that are directly comparable. This study illustrates that improved quantitative analysis can change implementation prioritization for air pollution and greenhouse gas control measures in Mexico City.

  18. Forest management in India. Local versus state control of forest resources

    Energy Technology Data Exchange (ETDEWEB)

    Wilk, J.

    1997-12-31

    Degradation and substantial losses to India`s forests have prompted a change in existing forestry management strategy. The new approach includes recognition of local participation in forestry management schemes but state control over most decisions is still dominant. Seen in terms of a common property resource system, India`s forests lack many of the factors usually considered inherent to successful management programs. Though India`s latest Forest Act affords more local involvement in forestry management, there continues to be an apparent lack of rights for local management groups over decision-making and the resource itself. Can this system enable the required balance between state and local management of India`s forests? 24 refs, 1 tab

  19. Prevention of brittle fracture of steel structures by controlling the local stress and strain fields

    Directory of Open Access Journals (Sweden)

    Moyseychik Evgeniy Alekseevich

    Full Text Available In the article the author offers a classification of the methods to increase the cold resistance of steel structural shapes with a focus on the regulation of local fields of internal stresses and strains to prevent brittle fracture of steel structures. The need of a computer thermography is highlighted not only for visualization of temperature fields on the surface, but also to control the fields of residual stresses and strains in a controlled element.

  20. The reasons for changes in the control of Dutch local government

    NARCIS (Netherlands)

    ter Bogt, H.J.; Haldma, T.

    2005-01-01

    The last fifteen years have seen a succession of changes in the management control of organizations in the Dutch local government sector, i.e. municipalities and provinces. These changes relate to, for example, organizational structures, financial management and human resources management, and also

  1. Controlling Lean Manufacturing in Multidivisional Organisations : Highlighting Local Interests and Contraints

    NARCIS (Netherlands)

    van der Steen, Martijn; Tillema, Sandra

    2018-01-01

    Purpose: This paper addresses the impact of a multidivisional structure on the implementation of lean manufacturing. It investigates how the controls employed by the corporate level impact the local implementation of lean manufacturing. Design/methodology/approach: The paper reports on case studies

  2. Local Control in the Era of Accountability: A Case Study of Wisconsin PreK

    Science.gov (United States)

    Graue, M. Elizabeth; Wilinski, Bethany; Nocera, Amato

    2016-01-01

    The opposing principles of local control and increased standardization are a prominent tension in the United States' education system. Since at least the early 1990s, this tension has taken shape around the accountability movement, defined by educational reforms that hold schools, teachers, and students accountable for performance on new…

  3. Controlling Lean Manufacturing in Multidivisional Organisations : Highlighting Local Interests and Contraints

    NARCIS (Netherlands)

    van der Steen, Martijn; Tillema, Sandra

    2017-01-01

    Purpose: This paper addresses the impact of a multidivisional structure on the implementation of lean manufacturing. It investigates how the controls employed by the corporate level impact the local implementation of lean manufacturing. Design/methodology/approach: The paper reports on case studies

  4. A neo-strategic planning approach to enhance local tobacco control programs.

    Science.gov (United States)

    Douglas, Malinda R; Carter, Sara Sally R; Wilson, Andrew P; Chan, Andie

    2015-01-01

    Research in tobacco control demonstrating best practices is widely disseminated; however, application at the local level is often difficult. Translating research into practice requires a concerted effort to develop an understanding of the evidence and how it can be applied within diverse contexts. A strategic planning infrastructure was developed to support the translation of evidence-based interventions into community practice. This paper highlights the strategic process of turning "know-what" into "know-how" to facilitate the strategic planning and implementation of tobacco control best practices at the local level. The purpose, people, process, and product strategies of knowledge management and translation provided a framework for the strategic planning infrastructure. The knowledge translation concepts of audience, motivations, and mechanisms were synergized in the neo-strategic planning component design. The participants were 20 community coalitions funded to implement local tobacco control programs. From 2004 to 2011, the strategic planners facilitated a cyclical process to translate research into practice using a trio of integrated tools, skill-building workshops on strategic planning, and grantee-driven technical assistance and consultation. In the short term, the usefulness of the strategic planning components to the programs was measured. The intermediate outcome was the successful movement of the community programs from the planning stage to the implementation stage. The achievement of community-level changes in planned tobacco control efforts was the overall outcome measure for the success of the local coalitions. Seventeen of 20 communities that began the planning process implemented strategic plans. All 17 of the programs implemented evidence-based practices, resulting in numerous tobacco-free policies, increased cessation, and increased support from the media and community. Bridging the gap between research and practice can enhance the practicality

  5. Prêmio Excel Rio Preto: a viabilidade de uma iniciativa municipal de incentivo a boas práticas ambientais e sociais na construção civil local

    OpenAIRE

    Thiago Zaldini Hernandes

    2015-01-01

    A indústria da construção civil tem significativo impacto ambiental, social e econômico no mundo. A mesma importância proporcional se observa no âmbito local, inclusive em cidades de médio porte, tomando-se como exemplo a cidade de São José do Rio Preto SP. Nesta cidade, foi observado que construtoras já desenvolvem ações isoladas de valorização de boas práticas nos âmbitos ambiental e social, mas demonstram pouca dinâmica de mobilização no sentido de sistematizar, aprofundar e disseminar ta...

  6. Strategies Implemented by 20 Local Tobacco Control Agencies to Promote Smoke-Free Recreation Areas, California, 2004-2007

    OpenAIRE

    Satterlund, Travis D.; Cassady, Diana; Treiber, Jeanette; Lemp, Cathy

    2011-01-01

    Introduction Since 2000, local jurisdictions in California have enacted hundreds of policies and ordinances in an effort to protect their citizens from the harmful effects of secondhand smoke. We evaluated strategies used by state-funded local tobacco control programs to enact local smoke-free policies involving outdoor recreational spaces. Methods The Tobacco Control Evaluation Center analyzed 23 final evaluation reports that discussed adopting local smoke-free policies in outdoor recreation...

  7. The effect of local violence on children's attention and impulse control.

    Science.gov (United States)

    Sharkey, Patrick T; Tirado-Strayer, Nicole; Papachristos, Andrew V; Raver, C Cybele

    2012-12-01

    We examined whether the burden of violence in a child's community environment alters the child's behavior and functioning in the classroom setting. To identify the effects of local violence, we exploited variation in the timing of local homicides, based on data from the Chicago Police Department, relative to the timing of interview assessments conducted as part of a randomized controlled trial conducted with preschoolers in Head Start programs from 2004-2006, the Chicago School Readiness Project. We compared children's scores when exposed to recent local violence with scores when no recent violence had occurred to identify causal effects. When children were assessed within a week of a homicide that occurred near their home, they exhibited lower levels of attention and impulse control and lower preacademic skills. The analysis showed strong positive effects of local violence on parental distress, providing suggestive evidence that parental responses may be a likely pathway by which local violence affects young children. Exposure to homicide generates acute psychological distress among caregivers and impairs children's self-regulatory behavior and cognitive functioning.

  8. Designing Transformations: Schools of excellence

    Science.gov (United States)

    Marie Fairburn, Susan

    2011-12-01

    For over 50 years, including some form of Space education in school curriculum has become an established approach for inspiring young minds to study the sciences and pursue science-based careers. Space camps and schools are active all around the globe and typically attract the 'best and the brightest' young minds. But the context of Space is broad and all young minds need the confidence and ability to make choices that will best serve them in the world of learning, life and work. Designing Transformations: can the context of 'Space' serve as an inclusive educational engagement model and career skills tool to achieve "Schools of Excellence" (SoE)? This paper presents a case study for democratising space education within Scotland; through a new Schools of Excellence Model, which uses design methodology to convey an educational experience. It further demonstrates how the SoE model proposes the context of Space to dovetail with Scotland's Curriculum for Excellence (CfE) , with particular relevance to skills for learning, life and work to build skills and foster career agility to equip individuals for the new and changing demands of the future workplace. Curriculum for Excellence (CfE) is a new approach to the curriculum, with its emphasis on outcomes rather than inputs.

  9. Leadership, excellence, creativity and innovation

    OpenAIRE

    Coulson-Thomas, Colin

    2016-01-01

    Raises questions about the meaning, purpose and practice of contemporary leadership in relation to excellence, creativity and innovation, covering leadership qualities, the context and requirements of leadership, leadership at different stages of development, creativity and innovation, CEOs and top down leadership, entrepreneurship and shared leadership, leading the network organisation, shared and collective leadership, the role and contribution of boards, key questions for boards, leadershi...

  10. Customer satisfaction and business excellence

    DEFF Research Database (Denmark)

    Kristensen, Kai; Martensen, Anne; Grønholdt, Lars

    The topic for this paper is the link between customer satisfaction and business performance, which makes it possible to use customer satisfaction measures as basis for creating business excellence. First, the paper presents microeconomic models for the relationship between customer satisfaction...

  11. Quality Management and Business Excellence

    Directory of Open Access Journals (Sweden)

    Vasile Dinu

    2017-02-01

    Full Text Available An excellent organization involves much more than the implementation and the certification of one or more models of management systems. It means developing techniques and tools of busin excellence which lead the organization to outstanding performance on quality, costs and deadlines in order to meet the expectations of all their stakeholders. Such an approach is needed especially in the context of an economy marked by globalization, extremely complex and dynamic that causes spectacular changes in the business environment by integrating quality management principles on purpose to develop sustainable excellence. Not coincidentally, the new edition of the European excellence model EFQM integrates for the first time the principle "managing with agility“ with the principles: “developing organizational capability”, “harnessing creativity & innovation”, “adding value to the customer”, “sustaining outstanding results” for the organization and “creating a sustainable future”. Also, the new model for quality management system defined by the edition from 2015 of ISO 9000 standards , promotes the process-based approach, incorporating the cycle "Plan - Do − Check − Act" (PDCA and the risk-based thinking, focusing on organizational change and innovation, in order to ensure a sustainable performance in business. Noteworthy is the endeavor for the development of a high-level structure for all international standards for management systems, aiming to harmonize these standards to facilitate the implementation of integrated management systems (quality − environment − security − social responsibility.

  12. Individually controlled localized chilled beam in conjunction with chilled ceiling: Part 2 – Human response

    DEFF Research Database (Denmark)

    Arghand, Taha; Pastuszka, Zuzanna; Bolashikov, Zhecho Dimitrov

    2016-01-01

    and 28°C. The supply airflow rate from the LCBCC was controlled by the subjects within the range of 10 to 13 L/s. In the case of CCMV subjects did not have control over the flow rate. The results showed that occupants’ overall and local thermal sensation acceptability improved at the workstation by using...... the LCBCC system compared to CCMV. The subjects felt less warm with the LCBCC and their thermal sensation was close to neutral. Most of the subjects achieved acceptable air movement at the workstation by the provided individual control of the flow rate from the LCBCC. Need for air movement was reported...

  13. Characterization of RanBPM Molecular Determinants that Control Its Subcellular Localization

    Science.gov (United States)

    Salemi, Louisa M.; Loureiro, Sandra O.; Schild-Poulter, Caroline

    2015-01-01

    RanBPM/RanBP9 is a ubiquitous, nucleocytoplasmic protein that is part of an evolutionary conserved E3 ubiquitin ligase complex whose function and targets in mammals are still unknown. RanBPM itself has been implicated in various cellular processes that involve both nuclear and cytoplasmic functions. However, to date, little is known about how RanBPM subcellular localization is regulated. We have conducted a systematic analysis of RanBPM regions that control its subcellular localization using RanBPM shRNA cells to examine ectopic RanBPM mutant subcellular localization without interference from the endogenously expressed protein. We show that several domains and motifs regulate RanBPM nuclear and cytoplasmic localization. In particular, RanBPM comprises two motifs that can confer nuclear localization, one proline/glutamine-rich motif in the extreme N-terminus which has a dominant effect on RanBPM localization, and a second motif in the C-terminus which minimally contributes to RanBPM nuclear targeting. We also identified a nuclear export signal (NES) which mutation prevented RanBPM accumulation in the cytoplasm. Likewise, deletion of the central RanBPM conserved domains (SPRY and LisH/CTLH) resulted in the relocalization of RanBPM to the nucleus, suggesting that RanBPM cytoplasmic localization is also conferred by protein-protein interactions that promote its cytoplasmic retention. Indeed we found that in the cytoplasm, RanBPM partially colocalizes with microtubules and associates with α-tubulin. Finally, in the nucleus, a significant fraction of RanBPM is associated with chromatin. Altogether, these analyses reveal that RanBPM subcellular localization results from the combined effects of several elements that either confer direct transport through the nucleocytoplasmic transport machinery or regulate it indirectly, likely through interactions with other proteins and by intramolecular folding. PMID:25659156

  14. TB control policies in European countries: international standards and local practice of their implementation

    Directory of Open Access Journals (Sweden)

    Semigina, Tetyana

    2012-07-01

    Full Text Available BACKGROUND: Ukraine belongs to countries with high level of tuberculosis (TB incidence. Despite measures implemented by the state and non-governmental organizations (NGOs, the situation with the spread of TB stays alarming.MATERIAL AND METHODS: Analysis of legal acts, international standards, national reports and other official documents related to TB control was carried out for such countries as the UK, the Netherlands, Moldova, Romania, and Ukraine.RESULTS: All the European countries under consideration are running the DOTS approach (DOTS - Directly Observed Treatment Short-Course, recommended by the WHO. The Netherlands and the UK have been using this approach for a long time (since 1970; and in the Netherlands resources are mobilized by the government and NGOs working both on the national and international levels. In Romania, Moldova, and Ukraine DOTS approach is not widely used and is implemented mostly in an adapted form.All the selected countries have national plans for TB control with clearly defined goals and ways to achieve them. However, while implementing TB control policy local features are taken into account: in the UK national policy is adjusted for implementation at the local level, in Moldova there are some local programs of TB control. The UK has introduce case managers for each patient with TB, Romania has the special managers to implement the national TB control program.Ukraine is characterized with fragmentary funding of TB control, lack of coordination mechanisms for the NGOs using international funds, which endangers the overall achievement of the policy goal. Ukraine's legislation contains provisions that interfere with implementation of current strategies to strengthen the health system in general and to improve TB control in particular. Currently, such local features as population mobility, poor coordination of TB control, inadequate attention to spread of TB among HIV-infected, drug resistance inhibit the

  15. Control of local ion transport to create unique functional nanodevices based on ionic conductors

    Directory of Open Access Journals (Sweden)

    Kazuya Terabe, Tsuyoshi Hasegawa, Changhao Liang and Masakazu Aono

    2007-01-01

    Full Text Available The development of nanometer-scale devices operating under a new principle that could overcome the limitations of current semiconductor devices has attracted interest in recent years. We propose that nanoionic devices that operate by controlling the local transport of ions are promising in this regard. It is possible to control the local transport of ions using the solid electrochemical properties of ionic and electronic mixed conductors. As an example of this concept, here, we report a method of controlling the transport of silver ions of the mixed-conductor silver sulfide (Ag2S crystal and basic research on nanoionic devices based on this mixed conductor. These devices show unique functions such as atom deposition, resistance switching, and quantum point contact switching. The switches operate through the formation and dissolution of an atomic bridge between the electrodes, and the behavior is realized by control of the local solid-state electrochemical reaction. Potential nanoionic devices utilizing the unique functions and characters that do not exist in conventional semiconductor devices are discussed.

  16. Spine Cryoablation: Pain Palliation and Local Tumor Control for Vertebral Metastases.

    Science.gov (United States)

    Tomasian, A; Wallace, A; Northrup, B; Hillen, T J; Jennings, J W

    2016-01-01

    Percutaneous cryoablation has emerged as a minimally invasive technique for the management of osseous metastases. The purpose of this study was to assess the safety and effectiveness of percutaneous imaging-guided spine cryoablation for pain palliation and local tumor control for vertebral metastases. Imaging-guided spine cryoablation was performed in 14 patients (31 tumors) with vertebral metastases refractory to conventional chemoradiation therapy or analgesics, to achieve pain palliation and local tumor control in this retrospective study. Spinal nerve and soft-tissue thermal protection techniques were implemented in all ablations. Patient response was evaluated by a pain numeric rating scale administered before the procedure and 1 week, 1 month, and 3 months after the procedure. Pre- and postprocedural analgesic requirements (expressed as morphine-equivalent dosages) were also analyzed at the same time points. Pre- and postprocedural cross-sectional imaging was evaluated in all patients to assess local control (no radiographic evidence of disease at the treated sites). Complications were monitored. Analysis of the primary end points was undertaken via paired-comparison procedures by using the Wilcoxon signed rank test. Thirty-one tumors were ablated in 14 patients (9 women and 5 men; 20-73 years of age; mean age, 53 years). The most common tumor location was in the lumbar spine (n = 14, 45%), followed by the thoracic spine (n = 8, 26%), sacrum (n = 6, 19%), coccyx (n = 2, 6%), and cervical spine (n = 1, 3%). There were statistically significant decreases in the median numeric rating scale score and analgesic usage at 1-week, 1-month, and 3-month time points (P tumor control was achieved in 96.7% (30/31) of tumors (median follow-up, 10 months). Two patients had transient postprocedural unilateral lower extremity radiculopathy and weakness. Percutaneous imaging-guided spine cryoablation is a safe and effective treatment for pain palliation and local tumor control

  17. Role of the Radiotherapy Boost on Local Control in Ductal Carcinoma In Situ

    Directory of Open Access Journals (Sweden)

    Olivier Riou

    2012-01-01

    Full Text Available Ductal carcinoma in situ of the breast is associated with low mortality rates, but local relapse is a matter of concern in this disease. Risk factors for local relapse include young age, close or positive margins, and tumor necrosis. Whole breast irradiation following breast-conserving surgery for ductal carcinoma in situ significantly reduces the risk of local relapse as compared to breast-conserving surgery alone. Studies point to similar outcomes between breast-conserving surgery plus radiotherapy and mastectomy, in the absence of extensive disease. A complementary boost to the surgical bed improves outcomes for patients with invasive breast cancer. However, the effect of this strategy has never been prospectively reported for ductal carcinoma in situ. Two randomized controlled trials assessing this issue are ongoing. This paper represents an update on available literature about radiotherapy for DCIS with a special focus on the role of a radiotherapy boost to the tumor bed.

  18. ¿ES NECESARIO UN NUEVO MODELO DE CONTROLES SOBRE LOS ENTES LOCALES?

    Directory of Open Access Journals (Sweden)

    Marcos Almeida Cerreda

    2008-04-01

    Full Text Available The aim of this article is to examine the Spanish system of administrative controlupon the local authorities, as well as to evaluate other possible systems.Firstly, the article analyses two previous questions: the conceptual and taxonomicaldelimitation of the administrative control upon the local authorities, and the historical evolution of the Spanish system of administrativecontrol and its tension with the principle of local autonomy. Secondly, thearticle seeks to define which should ideally be the structure of the system ofcontrol that Spanish legislation should contemplate. In order to do so, thearticle explores whether such an ideal system should be pre-eminently judicialor administrative, and to which institution should correspond the establishmentof such a system and its implementation.

  19. Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer.

    Science.gov (United States)

    Tanderup, Kari; Fokdal, Lars Ulrik; Sturdza, Alina; Haie-Meder, Christine; Mazeron, Renaud; van Limbergen, Erik; Jürgenliemk-Schulz, Ina; Petric, Primoz; Hoskin, Peter; Dörr, Wolfgang; Bentzen, Søren M; Kirisits, Christian; Lindegaard, Jacob Christian; Pötter, Richard

    2016-09-01

    Currently, there is no consensus on dose prescription in image guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer. The purpose of this study was to provide evidence based recommendations for tumor dose prescription based on results from a multi-center patient series (retroEMBRACE). This study analyzed 488 locally advanced cervical cancer patients treated with external beam radiotherapy±chemotherapy combined with IGABT. Brachytherapy contouring and reporting was according to ICRU/GEC-ESTRO recommendations. The Cox Proportional Hazards model was applied to analyze the effect on local control of dose-volume metrics as well as overall treatment time (OTT), dose rate, chemotherapy, and tumor histology. With a median follow up of 46months, 43 local failures were observed. Dose (D90) to the High Risk Clinical Target Volume (CTV HR ) (p=0.022, HR=0.967 per Gy) was significant for local control, whereas increasing CTV HR volume (p=0.004, HR=1.017 per cm 3 ), and longer OTT (p=0.004, HR=1.023 per day) were associated with worse local control. Histology (p=0.084), chemotherapy (p=0.49) and dose rate (p=1.00) did not have significant impact on local control. Separate analyses according to stage of disease showed that dose to CTV HR , residual gross tumor volume (GTV res ), and Intermediate Risk CTV (CTV IR ) has significant impact on local control. CTV HR dose of ⩾85Gy (D90) delivered in 7weeks provides 3-year local control rates of >94% in limited size CTV HR (20cm 3 ), >93% in intermediate size (30cm 3 ) and >86% in large size (70cm 3 ) CTV HR . CTV IR and GTV res dose of ⩾60Gy and ⩾95Gy (D98) leads to similar local control. A dose of 5Gy (CTV HR ) is required to compensate an increase of OTT by one week. Increased CTV HR volume by 10cm 3 requires additional 5Gy for equivalent local control. Copyright © 2016. Published by Elsevier Ireland Ltd.

  20. Excel Spreadsheets for Algebra: Improving Mental Modeling for Problem Solving

    Science.gov (United States)

    Engerman, Jason; Rusek, Matthew; Clariana, Roy

    2014-01-01

    This experiment investigates the effectiveness of Excel spreadsheets in a high school algebra class. Students in the experiment group convincingly outperformed the control group on a post lesson assessment. The student responses, teacher observations involving Excel spreadsheet revealed that it operated as a mindtool, which formed the users'…

  1. Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.

    Science.gov (United States)

    Sills, Erin O; Herrera, Diego; Kirkpatrick, A Justin; Brandão, Amintas; Dickson, Rebecca; Hall, Simon; Pattanayak, Subhrendu; Shoch, David; Vedoveto, Mariana; Young, Luisa; Pfaff, Alexander

    2015-01-01

    Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM) offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual) scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012). This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and permutations on policies

  2. Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.

    Directory of Open Access Journals (Sweden)

    Erin O Sills

    Full Text Available Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012. This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and

  3. Local Voltage Control in Distribution Networks: A Game-Theoretic Perspective: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Xinyang; Tian, Jie; Chen, Lijun; Dall' Anese, Emiliano

    2016-09-01

    Inverter-based voltage regulation is gaining importance to alleviate emerging reliability and power-quality concerns related to distribution systems with high penetration of photovoltaic (PV) systems. This paper seeks contribution in the domain of reactive power compensation by establishing stability of local Volt/VAr controllers. In lieu of the approximate linear surrogate used in the existing work, the paper establishes existence and uniqueness of an equilibrium point using nonlinear AC power flow model. Key to this end is to consider a nonlinear dynamical system with non-incremental local Volt/VAr control, cast the Volt/VAr dynamics as a game, and leverage the fixed-point theorem as well as pertinent contraction mapping argument. Numerical examples are provided to complement the analytical results.

  4. Prototyping the E-ELT M1 local control system communication infrastructure

    Science.gov (United States)

    Argomedo, J.; Kornweibel, N.; Grudzien, T.; Dimmler, M.; Andolfato, L.; Barriga, P.

    2016-08-01

    The primary mirror of the E-ELT is composed of 798 hexagonal segments of about 1.45 meters across. Each segment can be moved in piston and tip-tilt using three position actuators. Inductive edge sensors are used to provide feedback for global reconstruction of the mirror shape. The E-ELT M1 Local Control System will provide a deterministic infrastructure for collecting edge sensor and actuators readings and distribute the new position actuators references while at the same time providing failure detection, isolation and notification, synchronization, monitoring and configuration management. The present paper describes the prototyping activities carried out to verify the feasibility of the E-ELT M1 local control system communication architecture design and assess its performance and potential limitations.

  5. Autonomous tracked robots in planar off-road conditions modelling, localization, and motion control

    CERN Document Server

    González, Ramón; Guzmán, José Luis

    2014-01-01

    This monograph is framed within the context of off-road mobile robotics. In particular, it discusses issues related to modelling, localization, and motion control of tracked mobile robots working in planar slippery conditions. Tracked locomotion constitutes a well-known solution for mobile platforms operating over diverse challenging terrains, for that reason, tracked robotics constitutes an important research field with many applications (e.g. agriculture, mining, search and rescue operations, military activities). The specific topics of this monograph are: historical perspective of tracked vehicles and tracked robots; trajectory-tracking model taking into account slip effect; visual-odometry-based localization strategies; and advanced slip-compensation motion controllers ensuring efficient real-time execution. Physical experiments with a real tracked robot are presented showing the better performance of the suggested novel approaches to known techniques.   Keywords: longitudinal slip, visual odometry, slip...

  6. Perpendicular local magnetization under voltage control in Ni films on ferroelectric BaTiO₃ substrates.

    Science.gov (United States)

    Ghidini, Massimo; Maccherozzi, Francesco; Moya, Xavier; Phillips, Lee C; Yan, Wenjing; Soussi, Jordane; Métallier, Nicolas; Vickers, Mary E; Steinke, Nina-J; Mansell, Rhodri; Barnes, Crispin H W; Dhesi, Sarnjeet S; Mathur, Neil D

    2015-02-25

    High-resolution magnetoelectric imaging is used to demonstrate electrical control of the perpendicular local magnetization associated with 125 nm-wide magnetic stripe domains in 100-nm-thick Ni films. This magnetoelectric coupling is achieved in zero magnetic field using strain from ferroelectric BaTiO3 substrates to control perpendicular anisotropy imposed by the growth stress. These findings may be exploited for perpendicular recording in nanopatterned hybrid media. © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. The Local Control Funding Formula: An Opportunity for Early Childhood & Children in Foster Care. Increasing Resources for Early Childhood through the Local Control Funding Formula: A Guide for Early Childhood Advocates

    Science.gov (United States)

    Children Now, 2016

    2016-01-01

    According to the new Local Control Funding Formula (LCFF) law, most school districts in California are responsible for using LCFF funds to improve outcomes for children in the foster care system. Each district has created a Local Control Accountability Plan (LCAP), the expenditure plan for LCFF. The LCAP is reviewed and revised annually by each…

  8. Distributed embedded controller development with petri nets application to globally-asynchronous locally-synchronous systems

    CERN Document Server

    Moutinho, Filipe de Carvalho

    2016-01-01

    This book describes a model-based development approach for globally-asynchronous locally-synchronous distributed embedded controllers.  This approach uses Petri nets as modeling formalism to create platform and network independent models supporting the use of design automation tools.  To support this development approach, the Petri nets class in use is extended with time-domains and asynchronous-channels. The authors’ approach uses models not only providing a better understanding of the distributed controller and improving the communication among the stakeholders, but also to be ready to support the entire lifecycle, including the simulation, the verification (using model-checking tools), the implementation (relying on automatic code generators), and the deployment of the distributed controller into specific platforms. Uses a graphical and intuitive modeling formalism supported by design automation tools; Enables verification, ensuring that the distributed controller was correctly specified; Provides flex...

  9. Electric-field control of magnetic domain wall motion and local magnetization reversal.

    Science.gov (United States)

    Lahtinen, Tuomas H E; Franke, Kévin J A; van Dijken, Sebastiaan

    2012-01-01

    Spintronic devices currently rely on magnetic switching or controlled motion of domain walls by an external magnetic field or spin-polarized current. Achieving the same degree of magnetic controllability using an electric field has potential advantages including enhanced functionality and low power consumption. Here we report on an approach to electrically control local magnetic properties, including the writing and erasure of regular ferromagnetic domain patterns and the motion of magnetic domain walls, in CoFe-BaTiO(3) heterostructures. Our method is based on recurrent strain transfer from ferroelastic domains in ferroelectric media to continuous magnetostrictive films with negligible magnetocrystalline anisotropy. Optical polarization microscopy of both ferromagnetic and ferroelectric domain structures reveals that domain correlations and strong inter-ferroic domain wall pinning persist in an applied electric field. This leads to an unprecedented electric controllability over the ferromagnetic microstructure, an accomplishment that produces giant magnetoelectric coupling effects and opens the way to electric-field driven spintronics.

  10. Response control for the externally excited van der Pol oscillator with non-local feedback

    Science.gov (United States)

    Maccari, Attilio

    2012-02-01

    A non-local control force is introduced in such a way to obtain a third-order nonlinear differential equation (jerk dynamics) and to control nonlinear vibrations in an externally excited van der Pol oscillator. Two first-order nonlinear ordinary differential equations governing the modulation of the amplitude and the phase of solutions are derived and subsequently the performance of the control strategy is investigated. Excitation amplitude-response and frequency-response curves are shown. In certain cases when the excitation amplitude is very low an approximate analytic solution corresponding to a modulated two-period quasi-periodic motion can be obtained for the uncontrolled system. Uncontrolled and controlled systems are compared and the appropriate choices for the feedback gains are found in order to reduce the amplitude peak of the response and to exclude the possibility of quasi-periodic motion. Numerical simulation confirms the validity of the new method.

  11. Local control unit for ITER-India gyrotron test facility (IIGTF)

    Energy Technology Data Exchange (ETDEWEB)

    Rathod, Vipal, E-mail: vipal.rathod@iter-india.org; Shah, Ronak; Mandge, Deepak; Parmar, Rajvi; Rao, S.L.

    2016-11-15

    Highlights: • A dedicated full scale ITER prototype Local Control Unit for ITER-India Gyrotron test facility. • National Instruments® make PXIe system for real time control & data acquisition and Siemens® PLC for sequence control function. • Hardwired FPGA based fast protection interlock system. • High speed analog fiber optical transmission link using V/F and F/V technique. • Software framework based on LabVIEW™ platform and ITER CODAC Core System. - Abstract: Electron Cyclotron system on ITER, is one of the important RF ancillary systems based on high power Gyrotron RF sources, that is used for plasma heating and current drive applications. To operate a Gyrotron source, various auxiliary systems and services such as Super Conducting Magnet set, High Voltage Power Supplies, Auxiliary Power Supplies, Waveguide components, Cooling water system and a Local Control Unit (LCU) are required. The LCU plays a very crucial role for the safe and reliable operation of Gyrotron system. A dedicated full scale ITER prototype LCU is being developed for testing and commissioning of an ITER like Test Gyrotron at ITER-India Gyrotron Test facility (IIGTF). The main functions of LCU include Sequence Control, Local Interlock Protection and Real Time Data Acquisition. PLC based slow controller is used for implementing the Sequence Control & Slow Interlock functions. Critical Protection Interlocks are required to have a response time of <10 μs and are implemented using custom built hardware and PXIe based fast controller. Also PXIe system is used for implementing Real Time Data Acquisition function that is required to have slow and fast acquisition with online visualization and off line analysis facility. A Signal Conditioning Unit (SCU) is used to interface and faithfully transmit the field signals to the remote control systems. Necessary controller hardware is procured and several pre-prototype developments have been taken up to establish the critical subsystems such as

  12. Local control and complications after radiation therapy for primary orbital lymphoma: A case for low-dose treatment

    Energy Technology Data Exchange (ETDEWEB)

    Minehan, K.J.; Martenson, J.A. Jr.; Garrity, J.A.; Kurtin, P.J.; Banks, P.M.; Chen, M.G.; Earle, J.D. (Mayo Clinic, Rochester, MN (USA))

    1991-04-01

    Orbital involvement at the time of initial presentation is unusual in non-Hodgkin's lymphoma. In an effort to identify potential ways of improving the radiotherapeutic management of this disease, the records of 22 patients were reviewed retrospectively. All had biopsy-proven orbital non-Hodgkin's lymphoma, and the minimal, median, and maximal durations of follow-up in surviving patients were 4.8 years, 7.0 years, and 17.4 years, respectively. Permanent local control was achieved in 21 of the 22 patients (96%). Complications were scored according to a grading scheme in which grade 1 was the least significant complication and grade 4 was blindness as a result of radiation therapy. Of the 12 patients who received a radiation dose less than 35 Gy, 6 developed a grade 1 or grade 2 complication. Of the 10 patients treated with greater than or equal to 35 Gy, 6 experienced a complication, 1 of whom had a grade 4 complication resulting in blindness and another who developed a severe keratitis, which was scored as a grade 3 complication resulting in decreased visual acuity. At last follow-up, 10 patients were alive at 4.8 to 17.4 years after completion of radiation therapy, 4 had died of intercurrent disease at 3 months to 10.6 years, and 8 had died of disease at 3 months to 15.8 years. Actuarial survival for the entire group was 75% at 5 years and 48% at 10 years. Survival in patients with Stage I AE disease (lymphoma confined to orbit) at presentation was 87% at 5 years and 50% at 10 years, and survival in patients with Stage II A through Stage IV disease was 36% at 5 years and at 10 years. Primary orbital lymphoma is an indolent disease characterized by prolonged survival after radiation therapy. Excellent local control can be achieved with radiation doses of 20 Gy to 35 Gy. Higher doses may result in an increased risk of complications.

  13. Does Local School Control Raise Student Outcomes?: Theory and Evidence on the Roles of School Autonomy and Community Participation

    OpenAIRE

    Gunnarsson, Victoria; Orazem, Peter; Sanchez, Mario A.; Verdisco, Aimee

    2004-01-01

    School autonomy and parental participation have been frequently proposed as ways of making schools more productive. Less clear is how governments can foster decentralized decision-making by local schools. This paper shows that across eight Latin-American countries, most of the variation in local control over school decisions exists within and not between countries. That implies that the exercise of local authority to manage schools is largely a local choice only modestly influenced by constit...

  14. Does Local School Control Raise Student Outcomes?: Evidence on the Roles of School Autonomy and Parental Participation

    OpenAIRE

    Gunnarsson, Victoria; Orazem, Peter; Sanchez, Mario A.; Verdisco, Aimee

    2009-01-01

    School autonomy and parental participation have been frequently proposed as ways of making schools more productive. Less clear is how governments can foster decentralized decision-making by local schools. This paper shows that across eight Latin-American countries, most of the variation in local control over school decisions exists within and not between countries. That implies that the exercise of local authority to manage schools is largely a local choice only modestly influenced by constit...

  15. Energy performance control of local collectivities. Good practices of european towns; Mesure des performances energetiques des collectivites locales. Bonnes pratiques de villes europeennes

    Energy Technology Data Exchange (ETDEWEB)

    Lacassagne, S.; Schilken, P.

    2003-01-01

    Some european towns developed a specific energy and environmental policy, function of many factors. Policies are implemented to favorite the energy consumption and the pollutant emission control. The actions of local collectivities in the domain have been analyzed following three axis: the measure of the energy performance of local collectivities, the territorial energy management tools, the energy integration in sectoral policies. This report takes stock on the first axis analysis. (A.L.B.)

  16. The Quest for Educational Excellence

    Directory of Open Access Journals (Sweden)

    Kathleen A. Tobin

    2015-04-01

    Full Text Available A review of the book “The Global Fourth Way: The Quest for Educational Excellence.” By Andy Hargreaves and Dennis Shirley. Thousand Oaks, CA: Corwin, 2012. ISBN: 978-1412987868 Individual chapters in The Global Fourth Way center on examples of high performance in Finland, Singapore, Alberta (Canada, Ontario (Canada, England, and California (US. Each captures the essence of educational models, practices, and issues in the region at large, before focusing on specific cases that support key values in their proposal.

  17. Excel-Based Business Analysis

    CERN Document Server

    Anari, Ali

    2012-01-01

    ai"The trend is your friend"is a practical principle often used by business managers, who seek to forecast future sales, expenditures, and profitability in order to make production and other operational decisions. The problem is how best to identify and discover business trends and utilize trend information for attaining objectives of firms.This book contains an Excel-based solution to this problem, applying principles of the authors' "profit system model" of the firm that enables forecasts of trends in sales, expenditures, profits and other business variables. The program,

  18. Conducting polymer nanowires for control of local protein concentration in solution

    Science.gov (United States)

    Morris, Joshua D.; Thourson, Scott B.; Panta, Krishna R.; Flanders, Bret N.; Payne, Christine K.

    2017-05-01

    Interfacing devices with cells and tissues requires new nanoscale tools that are both flexible and electrically active. We demonstrate the use of PEDOT:PSS conducting polymer nanowires for the local control of protein concentration in water and biological media. We use fluorescence microscopy to compare the localization of serum albumin in response to electric fields generated by narrow (760 nm) and wide (1.5 µm) nanowires. We show that proteins in deionized water can be manipulated over a surprisingly large micron length scale and that this distance is a function of nanowire diameter. In addition, white noise can be introduced during the electrochemical synthesis of the nanowire to induce branches into the nanowire allowing a single device to control multiple nanowires. An analysis of growth speed and current density suggests that branching is due to the Mullins-Sekerka instability, ultimately controlled by the roughness of the nanowire surface. These small, flexible, conductive, and biologically compatible PEDOT:PSS nanowires provide a new tool for the electrical control of biological systems.

  19. Local Control of Audio Environment: A Review of Methods and Applications

    Directory of Open Access Journals (Sweden)

    Jussi Kuutti

    2014-02-01

    Full Text Available The concept of a local audio environment is to have sound playback locally restricted such that, ideally, adjacent regions of an indoor or outdoor space could exhibit their own individual audio content without interfering with each other. This would enable people to listen to their content of choice without disturbing others next to them, yet, without any headphones to block conversation. In practice, perfect sound containment in free air cannot be attained, but a local audio environment can still be satisfactorily approximated using directional speakers. Directional speakers may be based on regular audible frequencies or they may employ modulated ultrasound. Planar, parabolic, and array form factors are commonly used. The directivity of a speaker improves as its surface area and sound frequency increases, making these the main design factors for directional audio systems. Even directional speakers radiate some sound outside the main beam, and sound can also reflect from objects. Therefore, directional speaker systems perform best when there is enough ambient noise to mask the leaking sound. Possible areas of application for local audio include information and advertisement audio feed in commercial facilities, guiding and narration in museums and exhibitions, office space personalization, control room messaging, rehabilitation environments, and entertainment audio systems.

  20. Regional and local controls on evaporation from a small reservoir in northern Ghana

    Science.gov (United States)

    Liebe, J. R.; van de Giesen, N.; Andreini, M.; Walter, M. T.; Steenhuis, T. S.

    2009-12-01

    In many semi-arid regions of the world, small reservoirs are an important form of water supply for the rural population. Among practitioners and scientists it is often a common perception that water storage in small reservoirs is particularly inefficient in semi-arid environments due to large evaporation losses. Even though evaporation losses from reservoirs have been studied extensively in the 1960’s and thereafter, the availability of modern micro-meteorological weather stations gives us insight into regional and local controls on reservoir evaporation. The presented research studied regional and local controls on evaporation from a small reservoir in northern Ghana. Regional evaporation controls were analyzed in terms of characteristics of prevailing atmospheric circulation patterns (wind direction, relative humidity/saturation deficit, and wind speed). The local controls were analyzed with a set of micro-meteorological weather stations set up around a reservoir and in its center, which allows to measure moisture pickup over the reservoir under different pre-conditions of air saturation. In the study area, prevailing wind directions and the associated meteorological characteristics have significant impact on reservoir evaporation. While under the frequent, moist SW winds there is little evaporation from the reservoir, dry SE winds lead to pronounced evaporation losses. The moisture pickup is therein not uniform over the water body, but clearly concentrated on the upwind edge of the reservoir. In addition, reservoir evaporation was determined with the reservoirs energy budget and Penman ET. Compared to land based Penman ET, excessive evaporation loss from the water body was not apparent.

  1. Excel2Genie: A Microsoft Excel application to improve the flexibility of the Genie-2000 Spectroscopic software.

    Science.gov (United States)

    Forgács, Attila; Balkay, László; Trón, Lajos; Raics, Péter

    2014-12-01

    Excel2Genie, a simple and user-friendly Microsoft Excel interface, has been developed to the Genie-2000 Spectroscopic Software of Canberra Industries. This Excel application can directly control Canberra Multichannel Analyzer (MCA), process the acquired data and visualize them. Combination of Genie-2000 with Excel2Genie results in remarkably increased flexibility and a possibility to carry out repetitive data acquisitions even with changing parameters and more sophisticated analysis. The developed software package comprises three worksheets: display parameters and results of data acquisition, data analysis and mathematical operations carried out on the measured gamma spectra. At the same time it also allows control of these processes. Excel2Genie is freely available to assist gamma spectrum measurements and data evaluation by the interested Canberra users. With access to the Visual Basic Application (VBA) source code of this application users are enabled to modify the developed interface according to their intentions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Localized Control of Curie Temperature in Perovskite Oxide Film by Capping-Layer-Induced Octahedral Distortion

    Science.gov (United States)

    Thomas, S.; Kuiper, B.; Hu, J.; Smit, J.; Liao, Z.; Zhong, Z.; Rijnders, G.; Vailionis, A.; Wu, R.; Koster, G.; Xia, J.

    2017-10-01

    With reduced dimensionality, it is often easier to modify the properties of ultrathin films than their bulk counterparts. Strain engineering, usually achieved by choosing appropriate substrates, has been proven effective in controlling the properties of perovskite oxide films. An emerging alternative route for developing new multifunctional perovskite is by modification of the oxygen octahedral structure. Here we report the control of structural oxygen octahedral rotation in ultrathin perovskite SrRuO3 films by the deposition of a SrTiO3 capping layer, which can be lithographically patterned to achieve local control. Using a scanning Sagnac magnetic microscope, we show an increase in the Curie temperature of SrRuO3 due to the suppression octahedral rotations revealed by the synchrotron x-ray diffraction. This capping-layer-based technique may open new possibilities for developing functional oxide materials.

  3. Control and local measurement of the spin chemical potential in a magnetic insulator.

    Science.gov (United States)

    Du, Chunhui; van der Sar, Toeno; Zhou, Tony X; Upadhyaya, Pramey; Casola, Francesco; Zhang, Huiliang; Onbasli, Mehmet C; Ross, Caroline A; Walsworth, Ronald L; Tserkovnyak, Yaroslav; Yacoby, Amir

    2017-07-14

    The spin chemical potential characterizes the tendency of spins to diffuse. Probing this quantity could provide insight into materials such as magnetic insulators and spin liquids and aid optimization of spintronic devices. Here we introduce single-spin magnetometry as a generic platform for nonperturbative, nanoscale characterization of spin chemical potentials. We experimentally realize this platform using diamond nitrogen-vacancy centers and use it to investigate magnons in a magnetic insulator, finding that the magnon chemical potential can be controlled by driving the system's ferromagnetic resonance. We introduce a symmetry-based two-fluid theory describing the underlying magnon processes, measure the local thermomagnonic torque, and illustrate the detection sensitivity using electrically controlled spin injection. Our results pave the way for nanoscale control and imaging of spin transport in mesoscopic systems. Copyright © 2017, American Association for the Advancement of Science.

  4. Local control of traffic flows in networks: Self-organisation of phase synchronised dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Laemmer, Stefan; Donner, Reik [TU Dresden, Andreas-Schubert-Str. 23, 01062 Dresden (Germany); Helbing, Dirk [ETH Zuerich, Universitaetstr. 41, 8092 Zuerich (Switzerland)

    2008-07-01

    The effective control of flows in urban traffic networks is a subject of broad economic interest. During the last years, efforts have been made to develop decentralised control strategies that take only the actual state of present traffic conditions into account. In this contribution, we introduce a permeability model for the local control of conflicting material flows on networks, which incorporates a self-organisation of the flows. The dynamics of our model is studied under different situations, with a special emphasis on the development of a phase synchronised switching behaviour at the nodes of the traffic network. In order to improve the potential applicability of our concept, we discuss how a proper demand anticipation and the definition of a priority function can be used to further optimise the performance of the presented strategy.

  5. Control and local measurement of the spin chemical potential in a magnetic insulator

    Science.gov (United States)

    Du, Chunhui; van der Sar, Toeno; Zhou, Tony X.; Upadhyaya, Pramey; Casola, Francesco; Zhang, Huiliang; Onbasli, Mehmet C.; Ross, Caroline A.; Walsworth, Ronald L.; Tserkovnyak, Yaroslav; Yacoby, Amir

    2017-07-01

    The spin chemical potential characterizes the tendency of spins to diffuse. Probing this quantity could provide insight into materials such as magnetic insulators and spin liquids and aid optimization of spintronic devices. Here we introduce single-spin magnetometry as a generic platform for nonperturbative, nanoscale characterization of spin chemical potentials. We experimentally realize this platform using diamond nitrogen-vacancy centers and use it to investigate magnons in a magnetic insulator, finding that the magnon chemical potential can be controlled by driving the system’s ferromagnetic resonance. We introduce a symmetry-based two-fluid theory describing the underlying magnon processes, measure the local thermomagnonic torque, and illustrate the detection sensitivity using electrically controlled spin injection. Our results pave the way for nanoscale control and imaging of spin transport in mesoscopic systems.

  6. 75 FR 48662 - Equity and Excellence Commission

    Science.gov (United States)

    2010-08-11

    ... Equity and Excellence Commission AGENCY: Office for Civil Rights, U.S. Department of Education. ACTION: Request for Nominations to Serve on the Equity and Excellence Commission. SUMMARY: The Secretary of... Equity and Excellence Commission. SUPPLEMENTARY INFORMATION: The Equity and Excellence Commission (Equity...

  7. Evaluation of Public Service Advertising Messages with Local and Non-Local Source Attribution: A Controlled Laboratory Experiment.

    Science.gov (United States)

    Lynn, Jerry R.; Gagnard, Alice

    A study was conducted to examine message evaluations of selected public service advertisements (PSAs) by a young adult population and to test whether local and nonlocal source attribution would influence those evaluations. In addition, the study investigated the extent to which audience characteristics such as fatalism (the degree to which a…

  8. Control and Monitoring of a Stepper Motor through a Local Area Network

    Directory of Open Access Journals (Sweden)

    POPOVICI, D.

    2007-11-01

    Full Text Available In these days due to the information technology there are many ways to control a remote servomotor. In the paper it is shown a simple and reliable way to handle the control and monitoring of a remote stepper motor using a Local Area Network (LAN. The hardware uses a common PIC microcontroller and a stand-alone Ethernet controller. The main program located in the flash program memory solves the following tasks: read packs through SPI (Serial Peripheral Interface from the Ethernet controller's buffer and decode them, encapsulate data to be sent with the Ethernet controller, control the on-off state of the transistors from the static converter and receive feedback directly from the optical sensor to monitor the actual position of the shaft. The microcontroller supervises also the Ethernet controller. The Ethernet controller's job is to receive data from the main application remote program that runs on a computer, via UTP cable. Then it stores the data for a short time in a buffer from which the microcontroller can read it. The microcontroller stores data on this Ethernet controller too and can command it to send data to the main application program running remotely. The main remote program is written in Visual C++ and has a friendly interface allowing to the operator to send commands to the stepper motor drive and monitor in a dedicated window position, speed or the control sequences for the power transistor drivers of the stepper motor. The operator can send specific commands to the drive such as Start, Stop, Accelerate, Decelerate, Spin Clockwise/Counter clockwise and the number of steps. The microcontroller stepper motor drive system shows good performance and reliability.

  9. Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear

    Science.gov (United States)

    Yu, Zhan; Yu, Min; Zhang, Zhibao; Hong, Ge; Xiong, Qingqing

    2014-07-01

    Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an average diameter of 492 nm. The heat-denatured nanoparticles had good cytocompatibility. The nanoparticles could adhere on and penetrate through the round window membrane of guinea pigs. The nanoparticles were analyzed as drug carriers to investigate the loading capacity and release behaviors. Rhodamine B was used as a model drug in this paper. Rhodamine B-loaded nanoparticles showed a controlled release profile and could be deposited on the osseous spiral lamina. We considered that the bovine serum albumin nanoparticles may have potential applications in the field of local drug delivery in the treatment of inner ear disorders.

  10. Repetitive transarterial chemoembolization (TACE) of liver metastases from gastric cancer: Local control and survival results

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, Thomas J., E-mail: T.Vogl@em.uni-frankfurt.de [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Gruber-Rouh, Tatjana; Eichler, Katrin [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Nour-Eldin, Nour-Eldin A. [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Department of Radiology, Faculty of Medicine, Cairo University, Cairo (Egypt); Trojan, Jörg [Department of Internal Medicine I, Johann Wolfgang Goethe-University Frankfurt (Germany); Zangos, Stephan [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Naguib, Nagy N.N. [Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe-University Frankfurt (Germany); Radiology Department, Faculty of Medicine, Alexandria University, Alexandria (Egypt)

    2013-02-15

    Objective: To evaluate the local tumor control and survival data after transarterial chemoembolization with different drug combinations in the palliative treatment of patients with liver metastases of gastric cancer. Materials and methods: The study was retrospectively performed. 56 patients (mean age, 52.4) with unresectable liver metastases of gastric cancer who did not respond to systemic chemotherapy were repeatedly treated with TACE in 4-week intervals. In total, 310 chemoembolization procedures were performed (mean, 5.5 sessions per patient). The local chemotherapy protocol consisted of mitomycin alone (30.4%), mitomycin and gemcitabine (33.9%), or mitomycin, gemcitabine and cisplatin (35.7%). Embolization was performed with lipiodol and starch microspheres. Local tumor response was evaluated by MRI according to RECIST. Survival data from first chemoembolization were calculated according to the Kaplan–Meier method. Results: The local tumor control was: complete response in 1.8% (n = 1), partial response in 1.8% (n = 1), stable disease in 51.8% (n = 29) and progressive disease in 44.6% (n = 25) of patients. The 1-, 2-, and 3-year survival rate from the start of chemoembolization were 58%, 38%, and 23% respectively. The median and mean survival times were 13 and 27.1 months. A Statistically significant difference between patients treated with different chemotherapy protocols was noted (ρ = 0.045) with the best survival time in the mitomycin, gemcitabine and cisplatin group. Conclusion: Transarterial chemoembolization is a minimally invasive therapy option for palliative treatment of liver metastases in patients with gastric cancer.

  11. Strategies implemented by 20 local tobacco control agencies to promote smoke-free recreation areas, California, 2004-2007.

    Science.gov (United States)

    Satterlund, Travis D; Cassady, Diana; Treiber, Jeanette; Lemp, Cathy

    2011-09-01

    Since 2000, local jurisdictions in California have enacted hundreds of policies and ordinances in an effort to protect their citizens from the harmful effects of secondhand smoke. We evaluated strategies used by state-funded local tobacco control programs to enact local smoke-free policies involving outdoor recreational spaces. The Tobacco Control Evaluation Center analyzed 23 final evaluation reports that discussed adopting local smoke-free policies in outdoor recreational facilities in California. These reports were submitted for the 2004 through 2007 funding period by local tobacco control organizations to the California Department of Public Health, Tobacco Control Program. We used a comparative technique whereby we coded passages and compared them by locale and case, focusing on strategies that led to the enactment of smoke-free policies. Our analysis found the following 6 strategies to be the most effective: 1) having a "champion" who helps to carry an objective forward, 2) tapping into a pool of potential youth volunteers, 3) collecting and using local data as a persuasive tool, 4) educating the community in smoke-free policy efforts, 5) working strategically in the local political climate, and 6) framing the policy appropriately. These strategies proved effective regardless of whether policies were voluntary, administrative, or legislative. Successful policy enactment required a strong foundation of agency funding and an experienced and committed staff. These results should be relevant to other tobacco control organizations that are attempting to secure local smoke-free policy.

  12. Virtual environment for local and remote control of a robot arm for support in engineering teaching

    Directory of Open Access Journals (Sweden)

    José T. Buitrago-Molina

    2014-01-01

    Full Text Available This paper presents the design and implementation of a virtual platform that allows simulation and local and remote command and control of the SCARA robot arm called UV-CERMA, which is installed at the Robotics Laboratory of the Escuela de Ingeniería Eléctrica y Electrónica, Facultad de Ingeniería, Universidad del Valle. The robot has been underutilized for some years due to the obsolete control system. The platform, focused on the engineering education methodology, consists of two applications which simulate the robot and permit its remote and local command and control. One of the applications was implemented on LabVIEW software of National Instruments and the other application was programmed on free software using the open source language Java. Both applications implement forward kinematics and inverse kinematics, have a module for trajectories planning and operation, a module for monitoring the values of the variables and a three dimensional model of the robot. To manipulate the robot, an interface with a joystick was developed, enhancing the versatility of the platform. The applications communicate with the real robot using the National Instruments data acquisition card NI USB-6211, and for the remote connection they have a client-server architecture using TCP/IP sockets.

  13. Initial results of local grid control using wind farms with grid support

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Poul; Hansen, Anca D.; Iov, F.; Blaabjerg, F.

    2005-09-01

    This report describes initial results with simulation of local grid control using wind farms with grid support. The focus is on simulation of the behaviour of the wind farms when they are isolated from the main grid and establish a local grid together with a few other grid components. The isolated subsystems used in the work presented in this report do not intend to simulate a specific subsystem, but they are extremely simplified single bus bar systems using only a few more components than the wind farm. This approach has been applied to make it easier to understand the dynamics of the subsystem. The main observation is that the fast dynamics of the wind turbines seem to be able to contribute significantly to the grid control, which can be useful where the wind farm is isolated with a subsystem from the main grid with surplus of generation. Thus, the fast down regulation of the wind farm using automatic frequency control can keep the subsystem in operation and thereby improve the reliability of the grid. (LN)

  14. Automatic boiling water reactor control rod pattern design using particle swarm optimization algorithm and local search

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Cheng-Der, E-mail: jdwang@iner.gov.tw [Nuclear Engineering Division, Institute of Nuclear Energy Research, No. 1000, Wenhua Rd., Jiaan Village, Longtan Township, Taoyuan County 32546, Taiwan, ROC (China); Lin, Chaung [National Tsing Hua University, Department of Engineering and System Science, 101, Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan (China)

    2013-02-15

    Highlights: ► The PSO algorithm was adopted to automatically design a BWR CRP. ► The local search procedure was added to improve the result of PSO algorithm. ► The results show that the obtained CRP is the same good as that in the previous work. -- Abstract: This study developed a method for the automatic design of a boiling water reactor (BWR) control rod pattern (CRP) using the particle swarm optimization (PSO) algorithm. The PSO algorithm is more random compared to the rank-based ant system (RAS) that was used to solve the same BWR CRP design problem in the previous work. In addition, the local search procedure was used to make improvements after PSO, by adding the single control rod (CR) effect. The design goal was to obtain the CRP so that the thermal limits and shutdown margin would satisfy the design requirement and the cycle length, which is implicitly controlled by the axial power distribution, would be acceptable. The results showed that the same acceptable CRP found in the previous work could be obtained.

  15. Optimisation of local heat networks by implementing modern control systems; Optimierung von Nahwaermenetzen mit moderner Regeltechnik

    Energy Technology Data Exchange (ETDEWEB)

    Siepmann, G. [Kieback und Peter GmbH und Co. KG, Berlin (Germany)

    2003-10-01

    In the community of Finnentrop, a local heat supply system balancing economic efficiency and environmental sustainability has been planned and implemented. The state-of-the-art control engineering connects and incorporates all installation components, ranging from heating through to substations optimizing all parts of the installation to ensure that only heat actually requested by the consumers is generated and transported. Flow temperature and revolutions of the pumps are controlled in accordance with the actual demand. The carrier of the installation itself performs the optimizations. The network data is also available to the malfunction management and accessible via interfaces for economical and statistical purposes. The installation in Finnentrop is a good example of how local heat networks and installations can be optimized by implementing modern control engineering. A further example is the technology 'Hast-Akku' which combines energy management and storage management intelligently. (orig.) [German] In Nahwaermeversorgungssystemen koennen durch den Einsatz moderner Regeltechnik erhebliche Energiesparpotenziale geschaffen werden. Gleichzeitig wird die Betriebssicherheit erhoeht, die Betriebsfuehrung optimiert und der Komfort fuer Waermekunden verbessert. Ein Beispiel dafuer ist das Nahwaerme-Projekt in der sauerlaendischen Gemeinde Finnentrop. (orig.)

  16. Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases.

    Science.gov (United States)

    Bardosh, Kevin

    2014-01-01

    Neglected Tropical Diseases (NTDs) are both drivers and manifestations of poverty and social inequality. Increased advocacy efforts since the mid-2000s have led to ambitious new control and elimination targets set for 2020 by the World Health Organisation. While these global aspirations represent significant policy momentum, there are multifaceted challenges in controlling infectious diseases in resource-poor local contexts that need to be acknowledged, understood and engaged. However a number of recent publications have emphasised the "neglected" status of applied social science research on NTDs. In light of the 2020 targets, this paper explores the social science/NTD literature and unpacks some of the ways in which social inquiry can help support effective and sustainable interventions. Five priority areas are discussed, including on policy processes, health systems capacity, compliance and resistance to interventions, education and behaviour change, and community participation. The paper shows that despite the multifaceted value of having anthropological and sociological perspectives integrated into NTD programmes, contemporary efforts underutilise this potential. This is reflective of the dominance of top-down information flows and technocratic approaches in global health. To counter this tendency, social research needs to be more than an afterthought; integrating social inquiry into the planning, monitoring and evaluating process will help ensure that flexibility and adaptability to local realities are built into interventions. More emphasis on social science perspectives can also help link NTD control to broader social determinants of health, especially important given the major social and economic inequalities that continue to underpin transmission in endemic countries.

  17. Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control.

    Science.gov (United States)

    Zips, Daniel; Böke, Simon; Kroeber, Theresa; Meinzer, Andreas; Brüchner, Kerstin; Thames, Howard D; Baumann, Michael; Yaromina, Ala

    2011-05-01

    Previous experiments showed that the fraction of radiobiologically hypoxic tumor cells (rHF) in un-treated tumors did not accurately predict local tumor control after fractionated irradiation. Thus, the prognostic value of rHF determined during fractionated irradiation was investigated. Six human squamous cell carcinoma lines were transplanted into nude mice and then irradiated with 15 fractions over 3 weeks. Thereafter, single dose irradiation under normal and clamped blood flow was given. Local tumor control rates were used to calculate the rHF and the TCD₅₀, i.e., the radiation dose necessary to control 50% of the tumors, after single dose irradiation. These values were compared with the in parallel determined TCD₅₀ after 30 fractions in 6 weeks. The rHF after 15 fractions varied between 28% and 100%. No correlation was found with the TCD₅₀ after 30 fractions in 6 weeks. Single dose top-up TCD₅₀ under ambient and clamp conditions after 15 fractions significantly correlated with TCD₅₀ after 30 fractions in 6 weeks. rHF after 15 fractions is not a prognostic parameter for the outcome after fractionated irradiation. In contrast, the radiobiological parameters number of tumor stem cells, intrinsic radiosensitivity, and number of radiobiologically hypoxic tumor cells appear promising to predict outcome after fractionated irradiation.

  18. Vision-Based Steering Control, Speed Assistance and Localization for Inner-City Vehicles

    Directory of Open Access Journals (Sweden)

    Miguel Angel Olivares-Mendez

    2016-03-01

    Full Text Available Autonomous route following with road vehicles has gained popularity in the last few decades. In order to provide highly automated driver assistance systems, different types and combinations of sensors have been presented in the literature. However, most of these approaches apply quite sophisticated and expensive sensors, and hence, the development of a cost-efficient solution still remains a challenging problem. This work proposes the use of a single monocular camera sensor for an automatic steering control, speed assistance for the driver and localization of the vehicle on a road. Herein, we assume that the vehicle is mainly traveling along a predefined path, such as in public transport. A computer vision approach is presented to detect a line painted on the road, which defines the path to follow. Visual markers with a special design painted on the road provide information to localize the vehicle and to assist in its speed control. Furthermore, a vision-based control system, which keeps the vehicle on the predefined path under inner-city speed constraints, is also presented. Real driving tests with a commercial car on a closed circuit finally prove the applicability of the derived approach. In these tests, the car reached a maximum speed of 48 km/h and successfully traveled a distance of 7 km without the intervention of a human driver and any interruption.

  19. Vision-Based Steering Control, Speed Assistance and Localization for Inner-City Vehicles

    Science.gov (United States)

    Olivares-Mendez, Miguel Angel; Sanchez-Lopez, Jose Luis; Jimenez, Felipe; Campoy, Pascual; Sajadi-Alamdari, Seyed Amin; Voos, Holger

    2016-01-01

    Autonomous route following with road vehicles has gained popularity in the last few decades. In order to provide highly automated driver assistance systems, different types and combinations of sensors have been presented in the literature. However, most of these approaches apply quite sophisticated and expensive sensors, and hence, the development of a cost-efficient solution still remains a challenging problem. This work proposes the use of a single monocular camera sensor for an automatic steering control, speed assistance for the driver and localization of the vehicle on a road. Herein, we assume that the vehicle is mainly traveling along a predefined path, such as in public transport. A computer vision approach is presented to detect a line painted on the road, which defines the path to follow. Visual markers with a special design painted on the road provide information to localize the vehicle and to assist in its speed control. Furthermore, a vision-based control system, which keeps the vehicle on the predefined path under inner-city speed constraints, is also presented. Real driving tests with a commercial car on a closed circuit finally prove the applicability of the derived approach. In these tests, the car reached a maximum speed of 48 km/h and successfully traveled a distance of 7 km without the intervention of a human driver and any interruption. PMID:26978365

  20. Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion

    Energy Technology Data Exchange (ETDEWEB)

    Curiel, Laura; Huang Yuexi; Hynynen, Kullervo [Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5 (Canada); Vykhodtseva, Natalia [Department of Radiology, Brigham and Women' s Hospital, EBRC 521, 221 Longwood Avenue, Boston, MA 02115 (United States)], E-mail: curiell@tbh.net

    2009-06-07

    The purpose of this study was to evaluate the feasibility of using localized harmonic motion (LHM) to monitor and control focused ultrasound surgery (FUS) in VX2 tumors in vivo. FUS exposures were performed on 13 VX2 tumors implanted in nine rabbits. The same transducer induced coagulation and generated a localized oscillatory motion by periodically varying the radiation force. A separate diagnostic ultrasound transducer tracked motion by cross-correlating echo signals at different instances. A threshold in motion amplitude was instituted to cease exposure. Coagulation was confirmed by T2-weighted MR images, thermal dose obtained through MR thermometry and histological examinations. For tumor locations achieving coagulation, the LHM amplitude was 9% (p = 0.04) to 57% (p < 0.0001) lower than that before exposure. Control was successful for 74 (69%) out of 108 cases, with 52 (48%) reaching the threshold and achieving coagulation and 22 (21%) never reaching threshold nor coagulating. For the 34 (31%) unsuccessful exposures, 16 (15%) never reached the threshold but coagulation occurred, and 18 (16%) reached threshold without coagulation confirmed. Noise or radio-frequency signal changes explained motion over- or underestimation in 24 (22%) cases; the remaining 10 (9%) had other causes of error. The control was generally successful, but sudden change or noise in the acquired echo signal caused failure. Coagulation after exposure could be validated by comparing amplitudes before and after exposure.

  1. Immunohistochemical localization of translationally controlled tumor protein in the mouse digestive system.

    Science.gov (United States)

    Sheverdin, Vadim; Jung, Jiwon; Lee, Kyunglim

    2013-09-01

    Translationally controlled tumor protein (TCTP) is a housekeeping protein, highly conserved among various species. It plays a major role in cell differentiation, growth, proliferation, apoptosis and carcinogenesis. Studies reported so far on TCTP expression in different digestive organs have not led to any understanding of the role of TCTP in digestion, so we localized TCTP in organs of the mouse digestive system employing immunohistochemical techniques. Translationally controlled tumor protein was found expressed in all organs studied: tongue, salivary glands, esophagus, stomach, small and large intestines, liver and pancreas. The expression of TCTP was found to be predominant in epithelia and neurons of myenteric nerve ganglia; high in serous glands (parotid, submandibular, gastric, intestinal crypts, pancreatic acini) and in neurons of myenteric nerve ganglia, and moderate to low in epithelia. In epithelia, expression of TCTP varied depending on its type and location. In enteric neurons, TCTP was predominantly expressed in the processes. Translationally controlled tumor protein expression in the liver followed porto-central gradient with higher expression in pericentral hepatocytes. In the pancreas, TCTP was expressed in both acini and islet cells. Our finding of nearly universal localization and expression of TCTP in mouse digestive organs points to the hitherto unrecognized functional importance of TCTP in the digestive system and suggests the need for further studies of the possible role of TCTP in the proliferation, secretion, absorption and neural regulation of the digestive process and its importance in the physiology and pathology of digestive process. © 2013 Anatomical Society.

  2. Edge localized modes control by resonant magnetic perturbations; Controle des instabilites de bord par perturbations magnetiques resonantes

    Energy Technology Data Exchange (ETDEWEB)

    Nardon, E

    2007-10-15

    The present work is dedicated to one of the most promising methods of control of the ELMs (Edge Localized Modes), based on a system of coils producing Resonant Magnetic Perturbations (RMPs). Our main objectives are, on the one hand, to improve the physical understanding of the mechanisms at play, and on the other hand to propose a concrete design of ELMs control coils for ITER. In order to calculate and analyze the magnetic perturbations produced by a given set of coils, we have developed the ERGOS code. The first ERGOS calculation was for the DIII-D ELMs control coils, the I-coils. It showed that they produce magnetic islands chains which overlap at the edge of the plasma, resulting in the ergodization of the magnetic field. We have then used ERGOS for the modelling of the experiments on ELMs control using the error field correction coils at JET and MAST. In the case of JET, we have shown the existence of a correlation between the mitigation of the ELMs and the ergodization of the magnetic field at the edge, in agreement with the DIII-D result. In order to design the ELMs control coils for ITER we have used ERGOS intensively, taking the case of the DIII-D I-coils as a reference. Three candidate designs came out, which we presented at the ITER Design Review, in 2007. Recently, the ITER management decided to provide a budget for building ELMs control coils, the design of which remains to be chosen between two of the three options that we proposed. Finally, in order to understand better the non-linear magnetohydrodynamics phenomena taking place in ELMs control by RMPs, we performed numerical simulations, in particular with the JOREK code for a DIII-D case. The simulations reveal the existence of convection cells induced at the edge by the magnetic perturbations, and the possible screening of the RMPs in presence of rotation.

  3. Simultaneous control of emission localization and two-photon absorption efficiency in dissymmetrical chromophores

    Energy Technology Data Exchange (ETDEWEB)

    Tretiak, Sergei [Los Alamos National Laboratory

    2009-01-01

    The aim of the present work is to demonstrate that combined spectral tuning of fluorescence and two-photon absorption (TPA) properties of multipolar chromophores can be achieved by introduction of slight electronic chemical dissymmetry. In that perspective, two novel series of structurally related chromophores have been designed and studied: a first series based on rod-like quadrupolar chromophores bearing different electron-donating (D) end groups and a second series based on three-branched octupolar chromophores built from a trigonal donating moiety and bearing various acceptor (A) peripheral groups. The influence of the electronic dissymmetry is investigated by combined experimental and theoretical studies of the linear and nonlinear optical properties of dissymmetric chromophores compared to their symmetrical counterparts. In both types of systems (i.e. quadrupoles and octupoles) experiments and theory reveal that excitation is essentially delocalized and that excitation involves synchronized charge redistribution between the different D and A moieties within the multipolar structure (i.e. concerted intramolecular charge transfer). In contrast, the emission stems only from a particular dipolar subunit bearing the strongest D or A moieties due to fast excitation localization after excitation prior to emission. Hence control of emission characteristics (polarization and emission spectrum) in addition to localization can be achieved by controlled introduction of electronic dissymmetry (i.e. replacement of one of the D or A end-groups by a slightly stronger D{prime} or A{prime} units). Interestingly dissymmetrical functionalization of both quadrupolar and octupolar compounds does not lead to significant loss in TPA responses and can even be beneficial due to the spectral broadening and peak position tuning that it allows. This study thus reveals an original molecular engineering route strategy allowing major TPA enhancement in multipolar structures due to concerted

  4. Hypofractionated Radiotherapy for Small-sized Hepatocellular Carcinoma as Salvage Therapy: Sustained Local Control and Safety

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Sun Hyun; Park, Hee Chul; Lim, Do Hoon; Lee, Jung Ae; Choi, Moon Seok; Lee, Joon Hyoek; Koh, Kwang Cheol; Paik, Seung Woon; Yoo, Byung Chul [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2010-11-15

    To evaluate the rate of tumor response, local control, and treatment-related complications after hypofractionated radiotherapy for recurrent hepatocelluar carcinoma (HCC) less than 5 cm in size. Among the HCC patients who were treated by radiotherapy (RT) between 2006 and 2007 after the failure of previous treatment, a total of 12 patients were treated with hypofractionated RT. The criteria for hypofractionated RT was as follows: 1) HCC less than 5 cm, 2) HCC not adjacent to a critical organ, 3) HCC without portal vein tumor thrombosis, and 4) less than 15% of normal liver volume that irradiated 50% of the prescribed dose. Hypofractionated RT was performed with 50 Gy delivered in 10 fractions, at a rate of 5 fractions per week. The evaluation of tumor response was determined by CT scans performed at 3 months after the cessation of RT, followed by the evaluation of toxicity by Common Terminology Criteria for Adverse Events version 3.0. The median follow-up period after radiotherapy was 18 months. A complete response (CR) was achieved in 5 of 12 lesions (41.7%) at CT performed at 3 months after the cessation, whereas the overall complete response was observed in 7 of 12 cases (58.3%). In-field local control rate was sustained in 83.3% of patients. All patients developed intra-hepatic metastases except for 2 patients. The overall survival rate was 90.0% at 1 year and 67.5% at 2 years, respectively. Three patients developed Grade 1 nausea during RT and 1 patient showed a progression of ascites after RT. There was no grade 3 or greater treatment-related toxicities. Hypofractionated RT for small-sized HCC as a salvage therapy showed a 58.3% CR rate and 83.3% of local control. Fifty Gy administered in 10 fractions of partial liver irradiation is considered as a tolerable dose that does not cause severe complications.

  5. Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation.

    Science.gov (United States)

    Yaromina, Ala; Thames, Howard; Zhou, Xuanjing; Hering, Sandra; Eicheler, Wolfgang; Dörfler, Annegret; Leichtner, Thomas; Zips, Daniel; Baumann, Michael

    2010-07-01

    To investigate the relationships between radiobiological hypoxic fraction (rHF), pimonidazole hypoxic fraction (pHF) as well as other histological parameters of the tumour microenvironment, and local tumour control after fractionated irradiation in human squamous cell carcinomas (hSCCs). Ten different hSCC cell lines were transplanted into nude mice and rHF was calculated from local tumour control rates after single dose irradiation under normal or clamped blood flow conditions. In parallel, tumours were irradiated with 30 fractions within 6 weeks. Radiation response was quantified as dose required to cure 50% of tumours (TCD(50)). Unirradiated tumours were excised for histological evaluation including relative hypoxic area (pHF), relative vascular area (RVA), and fraction of perfused vessels (PF). A weak but significant positive correlation between rHF (R(2)=0.6, p=0.014) and TCD(50) after fractionated irradiation was found. The pHF did not correlate with rHF but was significantly associated with the TCD(50) after single dose clamp (R(2)=0.8, p=0.003) and showed a trend for an association with TCD(50) after fractionated irradiation (R(2)=0.4, p=0.067). Relative vascular area and fraction of perfused vessels did not show an association with rHF or TCD(50) after fractionated irradiation. Our data suggest that radiobiological hypoxia contributes to the response after fractionated irradiation but that also other radiobiological mechanisms are involved. In the present study, pimonidazole labelling does not reflect rHF and has a limited value to predict local tumour control after fractionated irradiation. The association between pHF and TCD(50) after single dose clamp warrants further investigation. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  6. (Center of excellence: Microlaser microscope)

    Energy Technology Data Exchange (ETDEWEB)

    Webb, R.H.

    1992-01-01

    This Center-of-Excellence grant has two components: development of an imaging system based on microlaser arrays forms a central project among a group of laser diagnostic and therapeutic efforts primarily funded outside the grant. In these first 8 months we have set up the Microlaser Microscope using small microlaser arrays. We have emphasized the basics of microlaser handling and electronic addressing and the optics of the microscope. Details of electronics and optics given here will be used in the larger arrays which should be available soon. After a description of the central Microlaser Microscope project, we touch briefly on the other projects of the Center, which have been outstandingly fruitful this year. Publications are necessarily concerned with the smaller projects, since the Microlaser Microscope is in its early stages.

  7. Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer

    DEFF Research Database (Denmark)

    Tanderup, Kari; Fokdal, Lars Ulrik; Sturdza, Alina

    2016-01-01

    Background and purpose Currently, there is no consensus on dose prescription in image guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer. The purpose of this study was to provide evidence based recommendations for tumor dose prescription based on results from a multi...... Hazards model was applied to analyze the effect on local control of dose-volume metrics as well as overall treatment time (OTT), dose rate, chemotherapy, and tumor histology. Results With a median follow up of 46 months, 43 local failures were observed. Dose (D90) to the High Risk Clinical Target Volume...... (CTVHR) (p = 0.022, HR = 0.967 per Gy) was significant for local control, whereas increasing CTVHR volume (p = 0.004, HR = 1.017 per cm3), and longer OTT (p = 0.004, HR = 1.023 per day) were associated with worse local control. Histology (p = 0.084), chemotherapy (p = 0.49) and dose rate (p = 1.00) did...

  8. El control legal del gasto en el ámbito de las haciendas locales

    OpenAIRE

    Valiño Castro, Aurelia; Pablos Escobar, Laura de

    2000-01-01

    En las líneas que siguen, se efectúa un análisis de las características del control legal en las Haciendas Locales, centrándose el estudio especialmente en los Ayuntamientos. Para realizar el análisis del cumplimiento de las normas se han utilizado los datos de la Dirección General de Coordinación con las Haciendas Territoriales y los Informes del Tribunal de Cuentas. Este estudio permite poner de relieve no sólo el cumplimiento de normas que son preceptivas, sino también reflejar los princip...

  9. Performance Evaluation of Multichannel Adaptive Algorithms for Local Active Noise Control

    Science.gov (United States)

    DE DIEGO, M.; GONZALEZ, A.

    2001-07-01

    This paper deals with the development of a multichannel active noise control (ANC) system inside an enclosed space. The purpose is to design a real practical system which works well in local ANC applications. Moreover, the algorithm implemented in the adaptive controller should be robust, of low computational complexity and it should manage to generate a uniform useful-size zone of quite in order to allow the head motion of a person seated on a seat inside a car. Experiments were carried out under semi-anechoic and listening room conditions to verify the successful implementation of the multichannel system. The developed prototype consists of an array of up to four microphones used as error sensors mounted on the headrest of a seat place inside the enclosure. One loudspeaker was used as single primary source and two secondary sources were placed facing the seat. The aim of this multichannel system is to reduce the sound pressure levels in an area around the error sensors, following a local control strategy. When using this technique, the cancellation points are not only the error sensor positions but an area around them, which is measured by using a monitoring microphone. Different multichannel adaptive algorithms for ANC have been analyzed and their performance verified. Multiple error algorithms are used in order to cancel out different types of primary noise (engine noise and random noise) with several configurations (up to four channels system). As an alternative to the multiple error LMS algorithm (multichannel version of the filtered-X LMS algorithm, MELMS), the least maximum mean squares (LMMS) and the scanning error-LMS algorithm have been developed in this work in order to reduce computational complexity and achieve a more uniform residual field. The ANC algorithms were programmed on a digital signal processing board equipped with a TMS320C40 floating point DSP processor. Measurements concerning real-time experiments on local noise reduction in two

  10. A controlled trial of pain on skin infiltration with local anaesthetics.

    Science.gov (United States)

    Morris, R W; Whish, D K

    1984-05-01

    A double-blind, randomised controlled trial was performed to compare the pain experienced on intradermal and subcutaneous injection of lignocaine 1% with adrenaline 1:100,000, lignocaine 1%, procaine 1% and normal saline. A linear analogue pain scale was used to assess pain. Lignocaine with adrenaline caused the most pain and was more painful than lignocaine 1%, which in turn was more painful than procaine or normal saline. These differences were significant at p less than 0.05 or greater for all comparisons except procaine 1% and normal saline. In conclusion, procaine 1% appears to be the local anaesthetic of choice from among those tested for intradermal and subcutaneous injection.

  11. The Energy Box: Locally Automated Optimal Control of Residential Electricity Usage

    OpenAIRE

    Daniel Livengood; Richard Larson

    2009-01-01

    The Energy Box is proposed as a 24/7 background processor operating on a local computer or in a remote location, silently managing one's home or small business electrical energy usage hour-by-hour and even minute-by-minute. It operates best in an environment of demand-sensitive real-time pricing, now made feasible via `smart grid' technology. We assume that, in time, virtually every electrical device in a home or small business will be controllable from the Energy Box. There are multiple moti...

  12. Mesoporous silica/apatite nanocomposite: special synthesis route to control local drug delivery.

    Science.gov (United States)

    Sousa, A; Souza, K C; Sousa, E M B

    2008-05-01

    Synthetic hydroxyapatite is widely used in medicine and dentistry due its notable biocompatibility and bioactivity properties. The hydroxyapatite incorporation into silica has demonstrated excellent bioactivity or biodegradability, according to the content of calcium ions. Procedures to obtain ordered mesoporous silicates rely on the micelle-forming properties of a surfactant, whose chemical composition, size and concentration control the structural dimensions of the final material. This paper reports the synthesis of two types mesoporous materials: pure MCM-41 and a nanocomposite of apatite and mesoporous silica, MCM-41-HA. The samples were charged with atenolol as a model drug and in vitro release essays were carried out. The bioactivity behavior was investigated as a function of soaking time in simulated body fluid. The materials were characterized by X-ray diffraction, N2 adsorption, FTIR spectroscopy, scanning electron microscopy, dispersive energies spectroscopy, and transmission electron microscopy. The influence of the release rate of atenolol molecules from pure MCM-41 mesoporous and containing hydroxyapatite was demonstrated, since it results in a very slowly drug delivery from the nanocomposite system.

  13. Insecticide and community interventions to control Triatoma dimidiata in localities of the State of Veracruz, Mexico

    Directory of Open Access Journals (Sweden)

    Gloria Rojas Wastavino

    2004-06-01

    Full Text Available Three different interventions to control Triatoma dimidiata in the State of Veracruz were implemented: X-1 = whole dwelling spraying, X-2 = middle wall spraying, X-3 = household cleaning. Cyfluthrin was sprayed 3 times with 8 month intervals. After each spraying, insects were collected and sent to the laboratory to be recorded and to determine genus and species of the adult triatomine bugs, and nymphs were counted. Trypanosoma cruzi presence was determined. With X-1, the infestation, colonization, and natural infection indexes were reduced to 0% in the 3 localities, with respect to t0. With X-2, the infestation index was reduced to 10% at t3 in 3 localities; the colonization index was reduced to 0% in only 1 locality at t3, and the natural infection index was reduced to 0% at t3. With X-3 the 3 indexes were not effectively reduced but they decreased with respect to the baseline study. Insecticide application to the whole dwelling is a more efficient intervention than its application to only the lower half of the walls and to the cleaning of houses.

  14. Local optical control of ferromagnetism and chemical potential in a topological insulator.

    Science.gov (United States)

    Yeats, Andrew L; Mintun, Peter J; Pan, Yu; Richardella, Anthony; Buckley, Bob B; Samarth, Nitin; Awschalom, David D

    2017-09-26

    Many proposed experiments involving topological insulators (TIs) require spatial control over time-reversal symmetry and chemical potential. We demonstrate reconfigurable micron-scale optical control of both magnetization (which breaks time-reversal symmetry) and chemical potential in ferromagnetic thin films of Cr-(Bi,Sb)2Te3 grown on SrTiO3 By optically modulating the coercivity of the films, we write and erase arbitrary patterns in their remanent magnetization, which we then image with Kerr microscopy. Additionally, by optically manipulating a space charge layer in the underlying SrTiO3 substrates, we control the local chemical potential of the films. This optical gating effect allows us to write and erase p-n junctions in the films, which we study with photocurrent microscopy. Both effects are persistent and may be patterned and imaged independently on a few-micron scale. Dynamic optical control over both magnetization and chemical potential of a TI may be useful in efforts to understand and control the edge states predicted at magnetic domain walls in quantum anomalous Hall insulators.

  15. Improvement of Inventory Control Using Continuous Review Policy in A Local Hospital at Bandung City, Indonesia

    Directory of Open Access Journals (Sweden)

    Fina Hafnika

    2016-12-01

    Full Text Available Abstract. This research was aimed to analyze the excess inventories issue in pharmacy and medical equipment unit at a local hospital in Bandung which affected the service level of the hospital. As one of the busy hospital in Java, proven by the higher amount of the patient/year than in other average Java typical hospital, the hospital needs to concern about the pharmaceutical and medical equipment inventories in order to fulfill patients’ needs and in the same time keeping the inventory level under control. Therefore, an inventory control evaluation was conducted to determine the appropriate number of inventories and time of order to avoid the excessive goods in central warehouse of the hospital. By using probabilistic inventory model and continuous review policy, the pharmaceutical inventory in the hospital was calculated to compare the ideal and actual amount of the average inventory level (AIL. ABC (Always, Better, Control classification also classified in this research to identify the proper item which potentially can be reduced from the inventory. From the analysis, we have discovered that the hospital potentially able to reduce almost Rp 830 million or 57% from the overstock inventory level by using continuous review policy as the basis of inventory control calculation system. Keywords: Continuous review policy, inventory control, EOQ, ROP, AIL

  16. Postoperative intensity-modulated radiation therapy provides favorable local control and low toxicities in patients with soft tissue sarcomas in the extremities and trunk wall

    Directory of Open Access Journals (Sweden)

    Wang JY

    2015-10-01

    Full Text Available Jianyang Wang, Shulian Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Yexiong Li Department of Radiation Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Purpose: To investigate the efficacy and toxicity of postoperative intensity-modulated radiation therapy (IMRT for patients with soft tissue sarcomas (STSs in the extremities and trunk wall. Patients and methods: Eighty patients with localized STSs in the extremities and trunk wall treated with function-conserving surgery and postoperative IMRT were analyzed. The primary locations were in the extremities in 51 patients and in the trunk wall in 29 patients. The margins were positive in nine patients and negative in 71 patients. The median dose of IMRT was 64 Gy. Results: At a median follow-up time of 38 months, eight patients developed local recurrences. The 5-year local control (LC rate was 88.1%. The patients with negative margins exhibited much better LC than did those with positive margins (90% vs 64.8%, P=0.023. Multivariate analysis revealed that positive margin was an independent risk factor for LC. The 5-year distant metastasis-free survival, disease-free survival, and overall survival rates were 75.2%, 72.6%, and 83.6%, respectively. Large tumor size (>5 cm was significantly associated with poor overall survival. Edema and joint stiffness were observed in 17.6% and 9.8% of patients with extremity STSs, respectively. Conclusion: IMRT provides excellent LC and low toxicity for patients with STSs in the extremities and trunk wall. Keywords: soft tissue sarcoma, extremities and trunk wall, intensity-modulated radiation therapy, local control, toxicitiess

  17. Automatic process control for pipeline: an ally in the quest for excellence in quality; Controle automatizado do processo de revestimento de dutos: um aliado na busca da excelencia em qualidade

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Christian E.; Santos, Paulo T.; Nunes, Matheus; Sartori, Marcio [Soco Ril do Brasil S.A., Pindamonhangaba, SP (Brazil); Populin, German [Soco-Ril da Argentina S.A. (Argentina); Ferreira, Joaquim C. [Tenaris Confab, Pindamonhangaba, SP (Brazil)

    2004-07-01

    Process is any specific combination of machines, methods, tools and people which aim to obtain products or services with high quality. Any changing in one of these elements may result in another process. The concern in assuring its control totally owe to the necessity of having quickly answers related to the standards deviation. Herewith, it is possible to get as much uniformity as possible from that quality characteristic. Through a thickness automatic controlled system it may be possible to evaluate in real time the process itself, identifying tendencies of sequential or temporal performance. Therefore it is possible to act instantaneously adjusting the process, complying with client's specification. The present paper describes the applicability of a automatic controlled system and shows the advantages of its using. (author)

  18. Fabrication of micropatterned polymeric nanowire arrays for high-resolution reagent localization and topographical cellular control.

    Science.gov (United States)

    Fox, Cade B; Kim, Jean; Schlesinger, Erica B; Chirra, Hariharasudhan D; Desai, Tejal A

    2015-03-11

    Herein, we present a novel approach for the fabrication of micropatterned polymeric nanowire arrays that addresses the current need for scalable and customizable polymer nanofabrication. We describe two variations of this approach for the patterning of nanowire arrays on either flat polymeric films or discrete polymeric microstructures and go on to investigate biological applications for the resulting polymeric features. We demonstrate that the micropatterned arrays of densely packed nanowires facilitate rapid, low-waste drug and reagent localization with micron-scale resolution as a result of their high wettability. We also show that micropatterned nanowire arrays provide hierarchical cellular control by simultaneously directing cell shape on the micron scale and influencing focal adhesion formation on the nanoscale. This nanofabrication approach has potential applications in scaffold-based cellular control, biological assay miniaturization, and biomedical microdevice technology.

  19. Edge localized mode control experiments on MAST using resonant magnetic perturbations from in-vessel coils

    Science.gov (United States)

    Nardon, E.; Kirk, A.; Akers, R.; Bécoulet, M.; Cahyna, P.; De Temmerman, G.; Dudson, B.; Hnat, B.; Liu, Y. Q.; Martin, R.; Meyer, H.; Tamain, P.; Taylor, D.; Temple, D.; MAST Team

    2009-12-01

    Edge localized mode (ELM) control has been investigated on MAST with a set of in-vessel coils producing n = 3 perturbations. In spite of a broad enough region where the Chirikov parameter is above 1, according to the criterion employed for the design of the ITER ELM control coils, no effect was seen on type I ELMs. The behaviour on MAST is different from that in DIII-D in this respect. The coils do have an effect, however, on Ohmic L-mode plasmas and plasmas just above the L-H transition. In the former, they induce a density pump-out, modify the turbulence characteristics and edge radial electric field and produce a strike point splitting, while in the latter they can trigger ELMs in ELM-free plasmas.

  20. Edge localized mode control experiments on MAST using resonant magnetic perturbations from in-vessel coils

    Energy Technology Data Exchange (ETDEWEB)

    Nardon, E; Kirk, A; Akers, R; De Temmerman, G; Liu, Y Q; Martin, R; Meyer, H; Tamain, P; Taylor, D; Temple, D [EURATOM/UKAEA Fusion Association, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Becoulet, M [Association Euratom/CEA, CEA Cadarache, F-13108, St. Paul-lez-Durance (France); Cahyna, P [Institute of Plasma Physics AS CR v.v.i., Association EURATOM/IPP.CR, Prague (Czech Republic); Dudson, B [University of York, Heslington, York YO10 5DD (United Kingdom); Hnat, B, E-mail: eric.nardon@ukaea.org.u [Centre for Fusion, Space and Astrophysics, Warwick University, Coventry CV4 7AL (United Kingdom)

    2009-12-15

    Edge localized mode (ELM) control has been investigated on MAST with a set of in-vessel coils producing n = 3 perturbations. In spite of a broad enough region where the Chirikov parameter is above 1, according to the criterion employed for the design of the ITER ELM control coils, no effect was seen on type I ELMs. The behaviour on MAST is different from that in DIII-D in this respect. The coils do have an effect, however, on Ohmic L-mode plasmas and plasmas just above the L-H transition. In the former, they induce a density pump-out, modify the turbulence characteristics and edge radial electric field and produce a strike point splitting, while in the latter they can trigger ELMs in ELM-free plasmas.

  1. Dynamic contrast-enhanced MR imaging predicts local control in oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy.

    Directory of Open Access Journals (Sweden)

    Shu-Hang Ng

    Full Text Available The role of pretreatment dynamic contrast-enhanced perfusion MR imaging (DCE-PWI and diffusion-weighted MR imaging (DWI in predicting the treatment response of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC to chemoradiation remains unclear. We prospectively investigated the ability of pharmacokinetic parameters derived from pretreatment DCE-PWI and DWI to predict the local control of OHSCC patients treated with chemoradiation. Between August, 2010 and March, 2012, patients with untreated OHSCC scheduled for chemoradiation were eligible for this prospective study. DCE-PWI and DWI were performed in addition to conventional MRI. The relationship of local control with the following clinical and imaging variables was analyzed: the hemoglobin level, T-stage, tumor location, gross tumor volume, maximum standardized uptake value, metabolic tumor volume and total lesion glycolysis on FDG PET/CT, transfer constant (K (trans , volume of blood plasma and volume of extracellular extravascular space on DCE-PWI, and apparent diffusion coefficient on DWI of the primary tumor. The patients were also divided into a local control group and a local failure group, and their clinical and imaging parameters were compared. There were 58 patients (29 with oropharynx squamous cell carcinoma [SCC] and 29 with hypopharynx SCC with successful pretreatment DCE-PWI and DWI available for analysis. After a median follow-up of 18.2 months, 17 (29.3% participants had local failure, whereas the remaining 41 patients achieved local control. Univariate analysis revealed that only the K (trans value was significantly associated with local control (P = 0.03. When the local control and local failure groups were compared, significant differences were observed in K (trans and the tumor location (P = 0.01 and P = 0.04, respectively. In the multivariable analysis, only K (trans was statistically significant (P = 0.04. Our results suggest that pretreatment K (trans may help

  2. Acupuncture at local and distant points for tinnitus: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Shi Guang-Xia

    2012-11-01

    Full Text Available Abstract Background Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the theory of traditional Chinese medicine, acupoints located on both the adjacent and distal area of the disease can be needled to treat disease. Furthermore, the way of combining acupoints is for strengthening the curative effect. We aim to evaluate the efficacy of acupuncture at local points in combination with distal points in subjective tinnitus patients. Method This trial is a randomized, single-blind, controlled study. A total of 112 participants will be randomly assigned to one of four treatment groups receiving acupuncture treatment for 4 weeks. The primary outcome measure is subjective tinnitus loudness and annoyance perception, which is graded using the Visual Analogue Scale (VAS. The assessment is at baseline (before treatment initiation, 4 weeks after the first acupuncture session, and 8 weeks after the first acupuncture session. Discussion Completion of this trial will help to identify whether acupuncture at local acupoints in combination with distal acupoints may be more effective than needling points separately. Trial registration International Standard Randomized Controlled Trial Number Register: ISRCTN29230777

  3. Tectonic control of Triassic sedimentation in southern New Brunswick: Local and regional implications

    Science.gov (United States)

    Nadon, G. C.; Middleton, G. V.

    1984-10-01

    Both regional and local tectonics controlled the sediment distribution in the Fundy half-graben during the Triassic. Locally, alluvial fans built out into the basin from the western boundary fault along what is now the south shore of New Brunswick. The alluvial fan red beds of the Honeycomb Point Formation are covered by fluvial conglomerates of the Quaco Formation, which in turn are buried by a resurgence of alluvial fan deposition represented by the Echo Cove Formation. Pollen recovered from the upper part of the Echo Cove Formation indicates that, regionally, the system of Triassic-Jurassic grabens along the eastern seaboard is composed of two separate graben systems; one stretching from South Carolina to Connecticut, the other from the Gulf of Maine to the southern Grand Banks. Initial graben formation began at the southern end of each system, followed by successive grabens opening toward the north. The areal distribution of both graben systems appears to have been controlled by four large transform-fault systems from the Middle Triassic through the Jurassic. The age and overall distribution of sediments within the Fundy Basin confirm the existence of a hot spot along the Kelvin Seamount chain and refines determination of the position and timing of the initial rifting that led to the formation of the present Atlantic Ocean.

  4. Global frameworks, local strategies: Women's rights, health, and the tobacco control movement in Argentina.

    Science.gov (United States)

    Muñoz Martínez, Hepzibah; Pederson, Ann

    2018-02-23

    The article examines how civil society organisations in Argentina used the United Nations Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW) to frame the country's failure to enact strong national tobacco control legislation as a violation of women's rights in the late 2000s. We analyze this case study through the politics of scale, namely the social processes that produce, reproduce, and contest the boundaries of policies and socio-economic relations. This approach understands how multiple scales overlap and connect to obstruct or enhance the right to health in Latin America. In Argentina, the global organisation of tobacco companies, the reach of international financial institutions and the national dynamics of economic austerity and export-orientation promoted the local production and use of tobacco (leaf and cigarettes) and reproduced health inequalities in the country throughout the 1990s and the early 2000s. Yet, the visible legacy of local and national human rights struggles in the adoption of international human rights treaties into Argentina's national constitution allowed the tobacco control movement to link the scale of women's bodies to the right to health through the use of CEDAW to change national legislation, tackling the social determinants of the tobacco epidemic.

  5. Fractionated stereotactic radiotherapy of glomus jugulare tumors. Local control, toxicity, symptomatology, and quality of life

    Energy Technology Data Exchange (ETDEWEB)

    Henzel, M.; Gross, M.W.; Failing, T.; Strassmann, G.; Engenhart-Cabillic, R. [Marburg Univ. (Germany). Dept. of Radiation Oncology; Hamm, K.; Surber, G.; Kleinert, G. [HELIOS Klinikum Erfurt (Germany). Dept. of Stereotactic Neurosurgery and Radiosurgery; Sitter, H. [Marburg Univ. (Germany). Dept. of Theoretical Surgery

    2007-10-15

    Background and Purpose: For glomus jugulare tumors, the goal of treatment is microsurgical excision. To minimize postoperative neurologic deficits, stereotactic radiosurgery (SRS) was performed as an alternative treatment option. Stereotactic fractionated radiotherapy (SRT) could be a further alternative. This study aims at the assessment of local control, side effects, and quality of life (QoL). Patients and Methods: Between 1999-2005, 17 patients were treated with SRT. 11/17 underwent previous operations. 6/17 received primary SRT. Treatment was delivered by a linear accelerator with 6-MV photons. Median cumulative dose was 57.0 Gy. Local control, radiologic regression, toxicity, and symptomatology were evaluated half-yearly by clinical examination and MRI scans. QoL was assessed by Short Form-36 (SF-36). Results: Median follow-up was 40 months. Freedom from progression and overall survival for 5 years were 100% and 93.8%. Radiologic regression was seen in 5/16 cases, 11/16 patients were stable. Median tumor shrinkage was 17.9% (p = 0.14). Severe acute toxicity (grade 3-4) or any late toxicity was never seen. Main symptoms improved in 9/16 patients, 7/16 were stable. QoL was not affected in patients receiving primary SRT. Conclusion: SRT offers an additional treatment option of high efficacy with less side effects, especially in cases of large tumors, morbidity, or recurrences after incomplete resections. (orig.)

  6. Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.

    Science.gov (United States)

    Sinha, Rahul; Allemand, Eric; Zhang, Zuo; Karni, Rotem; Myers, Michael P; Krainer, Adrian R

    2010-06-01

    Alternative splicing and posttranslational modifications (PTMs) are major sources of protein diversity in eukaryotic proteomes. The SR protein SF2/ASF is an oncoprotein that functions in pre-mRNA splicing, with additional roles in other posttranscriptional and translational events. Functional studies of SR protein PTMs have focused exclusively on the reversible phosphorylation of Ser residues in the C-terminal RS domain. We confirmed that human SF2/ASF is methylated at residues R93, R97, and R109, which were identified in a global proteomic analysis of Arg methylation, and further investigated whether these methylated residues regulate the properties of SF2/ASF. We show that the three arginines additively control the subcellular localization of SF2/ASF and that both the positive charge and the methylation state are important. Mutations that block methylation and remove the positive charge result in the cytoplasmic accumulation of SF2/ASF. The consequent decrease in nuclear SF2/ASF levels prevents it from modulating the alternative splicing of target genes, results in higher translation stimulation, and abrogates the enhancement of nonsense-mediated mRNA decay. This study addresses the mechanisms by which Arg methylation and the associated positive charge regulate the activities of SF2/ASF and emphasizes the significance of localization control for an oncoprotein with multiple functions in different cellular compartments.

  7. Using the SaTScan method to detect local malaria clusters for guiding malaria control programmes

    Directory of Open Access Journals (Sweden)

    Kok Gerdalize

    2009-04-01

    Full Text Available Abstract Background Mpumalanga Province, South Africa is a low malaria transmission area that is subject to malaria epidemics. SaTScan methodology was used by the malaria control programme to detect local malaria clusters to assist disease control planning. The third season for case cluster identification overlapped with the first season of implementing an outbreak identification and response system in the area. Methods SaTScan™ software using the Kulldorf method of retrospective space-time permutation and the Bernoulli purely spatial model was used to identify malaria clusters using definitively confirmed individual cases in seven towns over three malaria seasons. Following passive case reporting at health facilities during the 2002 to 2005 seasons, active case detection was carried out in the communities, this assisted with determining the probable source of infection. The distribution and statistical significance of the clusters were explored by means of Monte Carlo replication of data sets under the null hypothesis with replications greater than 999 to ensure adequate power for defining clusters. Results and discussion SaTScan detected five space-clusters and two space-time clusters during the study period. There was strong concordance between recognized local clustering of cases and outbreak declaration in specific towns. Both Albertsnek and Thambokulu reported malaria outbreaks in the same season as space-time clusters. This synergy may allow mutual validation of the two systems in confirming outbreaks demanding additional resources and cluster identification at local level to better target resources. Conclusion Exploring the clustering of cases assisted with the planning of public health activities, including mobilizing health workers and resources. Where appropriate additional indoor residual spraying, focal larviciding and health promotion activities, were all also carried out.

  8. Control of Surface-Localized, Enzyme-Assisted Self-Assembly of Peptides through Catalyzed Oligomerization.

    Science.gov (United States)

    Vigier-Carrière, Cécile; Wagner, Déborah; Chaumont, Alain; Durr, Baptiste; Lupattelli, Paolo; Lambour, Christophe; Schmutz, Marc; Hemmerlé, Joseph; Senger, Bernard; Schaaf, Pierre; Boulmedais, Fouzia; Jierry, Loïc

    2017-08-22

    Localized self-assembly allowing both spatial and temporal control over the assembly process is essential in many biological systems. This can be achieved through localized enzyme-assisted self-assembly (LEASA), also called enzyme-instructed self-assembly, where enzymes present on a substrate catalyze a reaction that transforms noninteracting species into self-assembling ones. Very few LEASA systems have been reported so far, and the control of the self-assembly process through the surface properties represents one essential step toward their use, for example, in artificial cell mimicry. Here, we describe a new type of LEASA system based on α-chymotrypsin adsorbed on a surface, which catalyzes the production of (KL)nOEt oligopeptides from a KLOEt (K: lysine; L: leucine; OEt ethyl ester) solution. When a critical concentration of the formed oligopeptides is reached near the surface, they self-assemble into β-sheets resulting in a fibrillar network localized at the interface that can extend over several micrometers. One significant feature of this process is the existence of a lag time before the self-assembly process starts. We investigate, in particular, the effect of the α-chymotrypsin surface density and KLOEt concentration on the self-assembly kinetics. We find that the lag time can be finely tuned through the surface density in α-chymotrypsin and KLOEt concentration. For a given surface enzyme concentration, a critical KLOEt concentration exists below which no self-assembly takes place. This concentration increases when the surface density in enzyme decreases.

  9. Intraincisional vs intraperitoneal infiltration of local anaesthetic for controlling early post-laparoscopic cholecystectomy pain

    Directory of Open Access Journals (Sweden)

    Gouda M El-labban

    2011-01-01

    Full Text Available Background: The study was designed to compare the effect of intraincisional vs intraperitoneal infiltration of levobupivacaine 0.25% on post-operative pain in laparoscopic cholecystectomy. Materials and Methods: This randomised controlled study was carried out on 189 patients who underwent laparoscopic cholecystectomy. Group 1 was the control group and did not receive either intraperitoneal or intraincisional levobupivacaine. Group 2 was assigned to receive local infiltration (intraincisional of 20 ml solution of levobupivacaine 0.25%, while Group 3 received 20 ml solution of levobupivacaine 0.25% intraperitoneally. Post-operative pain was recorded for 24 hours post-operatively. Results: Post-operative abdominal pain was significantly lower with intraincisional infiltration of levobupivacaine 0.25% in group 2. This difference was reported from 30 minutes till 24 hours post-operatively. Right shoulder pain showed significantly lower incidence in group 2 and group 3 compared to control group. Although statistically insignificant, shoulder pain was less in group 3 than group 2. Conclusion: Intraincisional infiltration of levobupivacaine is more effective than intraperitoneal route in controlling post-operative abdominal pain. It decreases the need for rescue analgesia.

  10. Sooty blotch and flyspeck control with fungicide applications based on calendar, local IPM, and warning system

    Directory of Open Access Journals (Sweden)

    Piérri Spolti

    2011-07-01

    Full Text Available The objective of this work was to compare fungicide application timing for the control of sooty blotch and flyspeck (SBFS of 'Fuji' apples in Rio Grande do Sul state, Brazil. The following treatments were evaluated in two growing seasons: two warning system-based (modified version of the Brown-Sutton-Hartmann system spray of captan plus thiophanate methyl, with or without summer pruning; two calendar/rain-based spray of captan or a mixture of captan plus thiophanate methyl; fungicide spray timing based on a local integrated pest management (IPM for the control of summer diseases; and a check without spraying. Sooty blotch and flyspeck incidence over time and their severity at harvest were evaluated. The highest number of spray was required by calendar/rain-based treatments (eight and seven sprays in the sequential years. The warning system recommended five and three sprays, in the sequential years, which led to the highest SBFS control efficacy expressed by the reduced initial inoculum and disease progress rate. Summer pruning enhanced SBFS control efficacy, especially by suppressing SBFS signs which tended to be restrained to the peduncle region of the fruit. Sooty blotch and flyspeck can be managed both with calendar and the grower-based IPM practices in Brazil, but a reduced number of sprays is required when the warning system is used.

  11. ITMO Photonics: center of excellence

    Science.gov (United States)

    Voznesenskaya, Anna; Bougrov, Vladislav; Kozlov, Sergey; Vasilev, Vladimir

    2016-09-01

    ITMO University, the leading Russian center in photonics research and education, has the mission to train highlyqualified competitive professionals able to act in conditions of fast-changing world. This paradigm is implemented through creation of a strategic academic unit ITMO Photonics, the center of excellence concentrating organizational, scientific, educational, financial, laboratory and human resources. This Center has the following features: dissemination of breakthrough scientific results in photonics such as advanced photonic materials, ultrafast optical and quantum information, laser physics, engineering and technologies, into undergraduate and graduate educational programs through including special modules into the curricula and considerable student's research and internships; transformation of the educational process in accordance with the best international educational practices, presence in the global education market in the form of joint educational programs with leading universities, i.e. those being included in the network programs of international scientific cooperation, and international accreditation of educational programs; development of mechanisms for the commercialization of innovative products - results of scientific research; securing financial sustainability of research in the field of photonics of informationcommunication systems via funding increase and the diversification of funding sources. Along with focusing on the research promotion, the Center is involved in science popularization through such projects as career guidance for high school students; interaction between student's chapters of international optical societies; invited lectures of World-famous experts in photonics; short educational programs in optics, photonics and light engineering for international students; contests, Olympics and grants for talented young researchers; social events; interactive demonstrations.

  12. Local-field effects and nanostructuring for controlling optical properties and enabling novel optical phenomena

    Science.gov (United States)

    Dolgaleva, Ksenia

    My Ph. D. thesis is devoted to the investigation of the methods of controlling and improving the linear and nonlinear optical properties of materials. Within my studies, two approaches are considered: nanostructuring and invoking local-field effects. These broad topics involve various projects that I have undertaken during my Ph. D. research. The first project is on composite laser gain media. It involves both nanostructuring and using local-field effects to control the basic laser parameters, such as the radiative lifetime, small-signal gain and absorption, and the saturation intensity. While being involved in this project, I have performed both theoretical and experimental studies of laser characteristics of composite materials. In particular, I have developed simple theoretical models for calculating the effective linear susceptibilities of layered and Maxwell Garnett composite materials with a gain resonance in one of their components. The analysis of the results given by the models suggests that local-field effects provide considerable freedom in controlling the optical properties of composite laser gain media. I have also experimentally measured the radiative lifetime of Nd:YAG nanopowder suspended in different liquids to extract information regarding local-field effects. The second project is devoted to the investigation of a not-well-known phenomenon that local-field effects can induce, which is microscopic cascading in nonlinear optics. This project involves the theoretical prediction of local-field-induced microscopic cascading effect in the fifth-order nonlinear response and its first experimental observation. This effect has been mostly overlooked or underestimated, but could prove useful in quantum optics. I have shown that, under certain conditions, the microscopic cascaded contribution can be a dominant effect in high-order nonlinearities. The third project is about characterization of laser performance of a new dye, oligofluorene, embedded into

  13. Randomised controlled trial of local corticosteroid injections for de Quervain's tenosynovitis in general practice

    Directory of Open Access Journals (Sweden)

    Groenier Klaas H

    2009-10-01

    Full Text Available Abstract Background De Quervain's tenosynovitis is a stenosing tenosynovitis of the first dorsal compartment of the wrist and leads to wrist pain and to impaired function of the wrist and hand. It can be treated by splinting, local corticosteroid injection and operation. In this study effectiveness of local corticosteroid injections for de Quervain's tenosynovitis provided by general practitioners was assessed. Methods Participants with de Quervain's tenosynovitis were recruited by general practitioners. Short-term outcomes (one week after injections were assessed in a randomised, placebo-controlled trial. Long-term effectiveness was evaluated in an open prospective cohort-study of steroid responders during a follow-up period of 12 months. Participants were randomised to one or two local injections of 1 ml of triamcinolonacetonide (TCA or 1 ml of NaCl 0.9% (placebo. Non-responders to NaCl were treated with additional TCA injections. Main outcomes were immediate treatment response, severity of pain, improvement as perceived by participant and functional disability using sub items hand and finger function of the Dutch Arthritis Impact Measurement Scale (Dutch AIMS-2-HFF. Results 11 general practitioners included 21 wrists in 21 patients. The TCA-group had better results for short-term outcomes treatment response (78% vs. 25%; p = 0.015, perceived improvement (78% vs. 33%; p = 0.047 and severity of pain (4.27 vs. 1.33; p = 0.031 but not for the Dutch-AIMS-HFF (2.71 vs. 1.92; p = 0.112. Absolute risk reduction for the main outcome short-term treatment response was 0.55 (95% CI: 0.34, 0.76 with a number needed to treat of 2 (95% CI: 1, 3. In the cohort of steroid responders (n = 12 the beneficial effects of steroid injections were sustained during the follow-up of 12 months regarding severity of pain (p = 0.67 and scores of Dutch AIMS-2-HFF (p = 0.36, but not for patient perceived improvement (p = 0.02. No adverse events were observed during the 12

  14. Selection with inbreeding control in simulated young bull schemes for local dairy cattle breeds.

    Science.gov (United States)

    Gandini, G; Stella, A; Del Corvo, M; Jansen, G B

    2014-03-01

    Local breeds are rarely subject to modern selection techniques; however, selection programs will be required if local breeds are to remain a viable livelihood option for farmers. Selection in small populations needs to take into account accurate inbreeding control. Optimum contribution selection (OCS) is efficient in controlling inbreeding and maximizes genetic gain. The current paper investigates genetic progress in simulated dairy cattle populations from 500 to 6,000 cows undergoing young bull selection schemes with OCS compared with truncation selection (TS) at an annual inbreeding rate of 0.003. Selection is carried out for a dairy trait with a base heritability of 0.3. A young bull selection scheme was used because of its simplicity in implementation. With TS, annual genetic gain from 0.111 standard deviation units with 500 cows increases rapidly to 0.145 standard deviation units with 4,000 cows. Then, genetic gain increases more slowly up to 6,000 cows. At the same inbreeding rate, OCS produces higher genetic progress than TS. Differences in genetic gain between OCS and TS vary from to 2 to 6.3%. Genetic gain is also improved by increasing the number of years that males can be used as sires of sires. When comparing OCS versus TS at different heritabilities, we observe an advantage of OCS only at high heritability, up to 8% with heritability of 0.9. By increasing the constraint on inbreeding, the difference of genetic gain between the 2 selection methods increases in favor of OCS, and the advantage at the inbreeding rate of 0.001 per generation is 6 times more than at the inbreeding rate of 0.003. Opportunities exist for selection even in dairy cattle populations of a few hundred females. In any case, selection in local breeds will most often require specific investments in infrastructure and manpower, including systems for accurate data recording and selection skills and the presence of artificial insemination and breeders organizations. A cost

  15. Local population structure of Plasmodium: impact on malaria control and elimination

    Directory of Open Access Journals (Sweden)

    Chenet Stella M

    2012-12-01

    Full Text Available Abstract Background Regardless of the growing interest in detecting population structures in malarial parasites, there have been limited discussions on how to use this concept in control programmes. In such context, the effects of the parasite population structures will depend on interventions’ spatial or temporal scales. This investigation explores the problem of identifying genetic markers, in this case microsatellites, to unveil Plasmodium genetic structures that could affect decisions in the context of elimination. The study was performed in a low-transmission area, which offers a good proxy to better understand problems associated with surveillance at the final stages of malaria elimination. Methods Plasmodium vivax samples collected in Tumeremo, Venezuela, between March 2003 and November 2004 were analysed. Since Plasmodium falciparum also circulates in many low endemic areas, P. falciparum samples from the same locality and time period were included for comparison. Plasmodium vivax samples were assayed for an original set of 25 microsatellites and P. falciparum samples were assayed for 12 microsatellites. Results Not all microsatellite loci assayed offered reliable local data. A complex temporal-cluster dynamics is found in both P. vivax and P. falciparum. Such dynamics affect the numbers and the type of microsatellites required for identifying individual parasites or parasite clusters when performing cross-sectional studies. The minimum number of microsatellites required to differentiate circulating P. vivax clusters differs from the minimum number of hyper-variable microsatellites required to distinguish individuals within these clusters. Regardless the extended number of microsatellites used in P. vivax, it was not possible to separate all individual infections. Conclusions Molecular surveillance has great potential; however, it requires preliminary local studies in order to properly interpret the emerging patterns in the context of

  16. Realisatie van Excel Kwadraat in de praktijk

    NARCIS (Netherlands)

    Dijkstra, Elma

    2013-01-01

    Dijkstra, E. M. (2013, 2 July). Realisatie van Excel Kwadraat in de praktijk [Realization of Excellent Education in practice]. Presentation held at the OLK-meeting, ITS, Radboud University, Nijmegen, The Netherlands.

  17. Excel for chemists: a comprehensive guide

    National Research Council Canada - National Science Library

    Billo, E. Joseph

    2011-01-01

    ..., biological, and medicinal calculations. Including a CD-ROM for Windows, this new edition provides chemists and students with the a detailed guide to using the current versions of Excel (Excel 2007 and 2010...

  18. Tracking Control of Mobile Robots Localized via Chained Fusion of Discrete and Continuous Epipolar Geometry, IMU and Odometry.

    Science.gov (United States)

    Tick, David; Satici, Aykut C; Shen, Jinglin; Gans, Nicholas

    2013-08-01

    This paper presents a novel navigation and control system for autonomous mobile robots that includes path planning, localization, and control. A unique vision-based pose and velocity estimation scheme utilizing both the continuous and discrete forms of the Euclidean homography matrix is fused with inertial and optical encoder measurements to estimate the pose, orientation, and velocity of the robot and ensure accurate localization and control signals. A depth estimation system is integrated in order to overcome the loss of scale inherent in vision-based estimation. A path following control system is introduced that is capable of guiding the robot along a designated curve. Stability analysis is provided for the control system and experimental results are presented that prove the combined localization and control system performs with high accuracy.

  19. EMG data warehouse with excel-based visual analytics

    OpenAIRE

    Lampret , Luka

    2012-01-01

    The aim of the thesis was to demonstrate that a state-of-the-art solution for management and analytical visualization of data can be implemented based on Excel 2010. We used a large and complex database of measurements of electrical activity in uterine smooth muscles during pregnancy in an animal model (pregnant sheep). The thesis comprises two parts. The first part fully exploits the functionalities of the latest version of Excel – ranging from advanced formulas through controls and VBA code...

  20. 77 FR 2711 - Equity and Excellence Commission

    Science.gov (United States)

    2012-01-19

    ... Equity and Excellence Commission AGENCY: Office for Civil Rights, Education. ACTION: Notice of open... Equity and Excellence Commission. This notice amends the January 5, 2012 notice by providing notice of a... Official, Equity and Excellence Commission, U.S. Department of Education, 400 Maryland Avenue SW...

  1. 76 FR 6774 - Equity and Excellence Commission

    Science.gov (United States)

    2011-02-08

    ... Equity and Excellence Commission AGENCY: Office for Civil Rights, Department of Education. ACTION: Notice... meeting of the Equity and Excellence Commission (Commission). The notice also describes the functions of... Chen, Designated Federal Official, Equity and Excellence Commission, U.S. Department of Education, 400...

  2. 75 FR 48661 - Equity and Excellence Commission

    Science.gov (United States)

    2010-08-11

    ... Equity and Excellence Commission AGENCY: U.S. Department of Education, Office for Civil Rights. ACTION: Notice of Establishment of the Equity and Excellence Commission. SUMMARY: The U.S. Secretary of Education (Secretary) announces the establishment of the Equity and Excellence Commission (Equity Commission or...

  3. 77 FR 484 - Equity and Excellence Commission

    Science.gov (United States)

    2012-01-05

    ... Equity and Excellence Commission AGENCY: Office for Civil Rights, U.S. Department of Education. ACTION...-coming meeting of the Equity and Excellence Commission (Commission). The notice also describes the..., Equity and Excellence Commission, U.S. Department of Education, 400 Maryland Avenue SW, Washington, DC...

  4. Industry Speed Bumps on Local Tobacco Control in Japan? The Case of Hyogo.

    Science.gov (United States)

    Yamada, Keiko; Mori, Nagisa; Kashiwabara, Mina; Yasuda, Sakiko; Horie, Rumi; Yamato, Hiroshi; Garçon, Loic; Armada, Francisco

    2015-01-01

    Despite being a signatory since 2004, Japan has not yet fully implemented Article 8 of the World Health Organization's Framework Convention on Tobacco Control regarding 100% protection against exposure to second-hand smoke (SHS). The Japanese government still recognizes designated smoking rooms (DSRs) in public space as a valid control measure. Furthermore, subnational initiatives for tobacco control in Japan are of limited effectiveness. Through an analysis of the Hyogo initiative in 2012, we identified key barriers to the achievement of a smoke-free environment. Using a descriptive case-study approach, we analyzed the smoke-free policy development process. The information was obtained from meeting minutes and other gray literature, such as public records, well as key informant interviews. Hyogo Prefecture established a committee to propose measures against SHS, and most committee members agreed with establishing completely smoke-free environments. However, the hospitality sector representatives opposed regulation, and tobacco companies were allowed to make a presentation to the committee. Further, political power shifted against completely smoke-free environments in the context of upcoming local elections, which was an obvious barrier to effective regulation. Throughout the approving process, advocacy by civil society for stronger regulation was weak. Eventually, the ordinance approved by the Prefectural Assembly was even weaker than the committee proposal and included wide exemptions. The analysis of Hyogo's SHS control initiative shed light on three factors that present challenges to implementing tobacco control regulations in Japan, from which other countries can also draw lessons: incomplete national legislation, the weakness of advocacy by the civil society, and the interference of the tobacco industry.

  5. Industry Speed Bumps on Local Tobacco Control in Japan? The Case of Hyogo

    Science.gov (United States)

    Yamada, Keiko; Mori, Nagisa; Kashiwabara, Mina; Yasuda, Sakiko; Horie, Rumi; Yamato, Hiroshi; Garçon, Loic; Armada, Francisco

    2015-01-01

    Background Despite being a signatory since 2004, Japan has not yet fully implemented Article 8 of the World Health Organization’s Framework Convention on Tobacco Control regarding 100% protection against exposure to second-hand smoke (SHS). The Japanese government still recognizes designated smoking rooms (DSRs) in public space as a valid control measure. Furthermore, subnational initiatives for tobacco control in Japan are of limited effectiveness. Through an analysis of the Hyogo initiative in 2012, we identified key barriers to the achievement of a smoke-free environment. Methods Using a descriptive case-study approach, we analyzed the smoke-free policy development process. The information was obtained from meeting minutes and other gray literature, such as public records, well as key informant interviews. Results Hyogo Prefecture established a committee to propose measures against SHS, and most committee members agreed with establishing completely smoke-free environments. However, the hospitality sector representatives opposed regulation, and tobacco companies were allowed to make a presentation to the committee. Further, political power shifted against completely smoke-free environments in the context of upcoming local elections, which was an obvious barrier to effective regulation. Throughout the approving process, advocacy by civil society for stronger regulation was weak. Eventually, the ordinance approved by the Prefectural Assembly was even weaker than the committee proposal and included wide exemptions. Conclusions The analysis of Hyogo’s SHS control initiative shed light on three factors that present challenges to implementing tobacco control regulations in Japan, from which other countries can also draw lessons: incomplete national legislation, the weakness of advocacy by the civil society, and the interference of the tobacco industry. PMID:26155758

  6. LOCAL CASE-CONTROL SAMPLING: EFFICIENT SUBSAMPLING IN IMBALANCED DATA SETS.

    Science.gov (United States)

    Fithian, William; Hastie, Trevor

    2014-10-01

    For classification problems with significant class imbalance, subsampling can reduce computational costs at the price of inflated variance in estimating model parameters. We propose a method for subsampling efficiently for logistic regression by adjusting the class balance locally in feature space via an accept-reject scheme. Our method generalizes standard case-control sampling, using a pilot estimate to preferentially select examples whose responses are conditionally rare given their features. The biased subsampling is corrected by a post-hoc analytic adjustment to the parameters. The method is simple and requires one parallelizable scan over the full data set. Standard case-control sampling is inconsistent under model misspecification for the population risk-minimizing coefficients θ*. By contrast, our estimator is consistent for θ* provided that the pilot estimate is. Moreover, under correct specification and with a consistent, independent pilot estimate, our estimator has exactly twice the asymptotic variance of the full-sample MLE-even if the selected subsample comprises a miniscule fraction of the full data set, as happens when the original data are severely imbalanced. The factor of two improves to [Formula: see text] if we multiply the baseline acceptance probabilities by c > 1 (and weight points with acceptance probability greater than 1), taking roughly [Formula: see text] times as many data points into the subsample. Experiments on simulated and real data show that our method can substantially outperform standard case-control subsampling.

  7. Control of swimming in the hydrozoan jellyfish Aequorea victoria: subumbrellar organization and local inhibition.

    Science.gov (United States)

    Satterlie, Richard A

    2008-11-01

    The subumbrella of the hydrozoan jellyfish Aequorea victoria (previously classified as Aequorea aequorea) is divided by numerous radial canals and attached gonads, so the subumbrellar musculature is partitioned into subumbrellar segments. The ectoderm of each segment includes two types of muscle: smooth muscle with a radial orientation, used for local (feeding and righting) and widespread (protective) radial responses, and striated muscle with a circular orientation which produces swim contractions. Two subumbrellar nerve nets were found, one of which stained with a commercial antibody produced against the bioactive peptide FMRFamide. Circular muscle cells produce a single, long-duration action potential with each swim, triggered by a single junctional potential. In addition, the circular cells are electrically coupled so full contractions require both electrotonic depolarization from adjacent cells and synaptic input from a subumbrellar nerve net. The radial cells, which form a layer superficial to the circular cells, are also activated by a subumbrellar nerve net, and produce short-duration action potentials. The radial muscle cells are electrically coupled to one another. No coupling exists between the two muscle layers. Spread of excitation between adjacent segments is decremental, and nerve net-activated junctional potentials disappear during local inhibition of swimming (such as with a radial response). Variable swim contractions are controlled by a combination of synaptic input from the motor network of the inner nerve ring, synaptic input from a subumbrellar nerve net, and electrotonic depolarization from adjacent, active muscle cells.

  8. Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation

    Directory of Open Access Journals (Sweden)

    Charlotte Proudhon

    2016-06-01

    Full Text Available V(DJ recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR loci in a lineage- and stage-specific manner. Unexpectedly, we find that both active and inactive AgR enhancers cooperate to disseminate their effects in a localized and long-range manner. Here, we demonstrate the importance of short-range contacts between active enhancers that constitute an Igk super-enhancer in B cells. Deletion of one element reduces the interaction frequency between other enhancers in the hub, which compromises the transcriptional output of each component. Furthermore, we establish that, in T cells, long-range contact and cooperation between the inactive Igk enhancer MiEκ and the active Tcrb enhancer Eβ alters enrichment of CBFβ binding in a manner that impacts Tcrb recombination. These findings underline the complexities of enhancer regulation and point to a role for localized and long-range enhancer-sharing between active and inactive elements in lineage- and stage-specific control.

  9. High Accuracy Passive Magnetic Field-Based Localization for Feedback Control Using Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Shaohui Foong

    2016-08-01

    Full Text Available In this paper, a novel magnetic field-based sensing system employing statistically optimized concurrent multiple sensor outputs for precise field-position association and localization is presented. This method capitalizes on the independence between simultaneous spatial field measurements at multiple locations to induce unique correspondences between field and position. This single-source-multi-sensor configuration is able to achieve accurate and precise localization and tracking of translational motion without contact over large travel distances for feedback control. Principal component analysis (PCA is used as a pseudo-linear filter to optimally reduce the dimensions of the multi-sensor output space for computationally efficient field-position mapping with artificial neural networks (ANNs. Numerical simulations are employed to investigate the effects of geometric parameters and Gaussian noise corruption on PCA assisted ANN mapping performance. Using a 9-sensor network, the sensing accuracy and closed-loop tracking performance of the proposed optimal field-based sensing system is experimentally evaluated on a linear actuator with a significantly more expensive optical encoder as a comparison.

  10. High Accuracy Passive Magnetic Field-Based Localization for Feedback Control Using Principal Component Analysis.

    Science.gov (United States)

    Foong, Shaohui; Sun, Zhenglong

    2016-08-12

    In this paper, a novel magnetic field-based sensing system employing statistically optimized concurrent multiple sensor outputs for precise field-position association and localization is presented. This method capitalizes on the independence between simultaneous spatial field measurements at multiple locations to induce unique correspondences between field and position. This single-source-multi-sensor configuration is able to achieve accurate and precise localization and tracking of translational motion without contact over large travel distances for feedback control. Principal component analysis (PCA) is used as a pseudo-linear filter to optimally reduce the dimensions of the multi-sensor output space for computationally efficient field-position mapping with artificial neural networks (ANNs). Numerical simulations are employed to investigate the effects of geometric parameters and Gaussian noise corruption on PCA assisted ANN mapping performance. Using a 9-sensor network, the sensing accuracy and closed-loop tracking performance of the proposed optimal field-based sensing system is experimentally evaluated on a linear actuator with a significantly more expensive optical encoder as a comparison.

  11. Local control of the resistivity of graphene through mechanically induced switching of a ferroelectric superlattice

    Science.gov (United States)

    Humed Yusuf, Mohammed; Gura, Anna; Du, Xu; Dawber, Matthew

    2017-06-01

    We exploit nanoscale mechanically induced switching of an artificially layered ferroelectric material, used as an active substrate, to achieve the local manipulation of the electrical transport properties of graphene. In Graphene Ferroelectric Field Effect Transistors (GFeFETs), the graphene channel’s charge state is controlled by an underlying ferroelectric layer. The tip of an atomic force microscope (AFM) can be used to mechanically ‘write’ nanoscale regions of the graphene channel and ‘read’ off the modulation in the transport behavior. The written features associated with the switching of ferroelectric domains remain polarized until an electrical reset operation is carried out. Our result provides a method for flexible and reversible nano-scale manipulation of the transport properties of a broad class of 2D materials.

  12. DEVELOMPENT OF A VEHICLE SECURITY SYSTEM WITH LOCAL AND REMOTE CONTROL AND EVENT NOTIFICATIONS

    Directory of Open Access Journals (Sweden)

    Juan Manuel Sánchez

    2013-12-01

    Full Text Available This article describes the development of a security monitoring device for vehicles which gives instant reports to the user about any anomaly that occurs in his absence. This device also allows remote and local control actions, using GSM technology and Bluetooth, giving more functionality than common vehicle security systems. In this paper the different development stages are presented, starting with a short review about existing relevant devices in order to identify the necessary functional requirements and innovation opportunities. Later, a block diagram of the device is presented and the specific design parameter are detailed. The final experimentation showed that the developed equipment has a greater functionality than existing devices and lower production cost.

  13. Public Health, Law, and Local Control: Destruction of the US Chemical Weapons Stockpile

    Science.gov (United States)

    Greenberg, Michael R.

    2003-01-01

    Destruction of US chemical weapons has begun at one of the 8 sites in the continental United States, was completed on Johnston Island in the Pacific Ocean, and is scheduled to begin in at least 3 other locations during the upcoming year. About 25% of the stockpile and 38% of the munitions had been destroyed as of December 31, 2002. However, the program has become controversial with regard to choice of technology, emergency management, and cost. This controversy is in large part due to efforts by some state and local governments and activist groups to play a more central role in a decisionmaking process that was once fully controlled by the US Army. PMID:12893599

  14. Topographically controlled soil moisture is the primary driver of local vegetation patterns across a lowland region

    DEFF Research Database (Denmark)

    Moeslund, Jesper Erenskjold; Arge, Lars; Bøcher, Peder Klith

    2013-01-01

    Topography is recognized as an important factor in controlling plant distribution and diversity patterns, but its scale dependence and the underlying mechanisms by which it operates are not well understood. Here, we used novel high-resolution (2-m scale) topographic data from more than 30500...... vegetation plots to assess the importance of topography for local plant diversity and distribution patterns across Denmark, a 43000 km2 lowland region. The vegetation data came from 901 nature conservation sites (mean size = 0.16 km2) distributed throughout Denmark, each having an average of 34 plots (five......, potential solar radiation, wind exposure, wetness index) and 10 vegetation measures representing species composition, richness and functional composition (average plant preferences along key environmental niche axes). We also investigated how overall site-level environmental characteristics affect...

  15. Applying locally optimal criterion for classifying highly-reliable products with a control.

    Science.gov (United States)

    Chiao, C H; Tseng, S T

    1996-01-01

    At the research and development stage, decision-makers may wish to classify several competing designs with respect to a control (or standard) one. The classification problem may become very difficult when the products are highly reliable, since only a few (or even no) failures may be observed under normal use condition. The accelerated life test model resolves this difficulty by shortening the time of life testing and quickly provides life data of products. For highly-reliable products with a Weibull log-linear model, we propose a classification rule based on a locally optimal criterion. A suitable sampling plan based on this rule is also developed. The performance of this rule is compared with a pairwise comparison classification rule. It is shown that the sample sizes needed for the new rule are considerably lower than those needed for the pairwise comparison rule.

  16. External beam radiotherapy for basal cell carcinoma. Local control and cosmetic outcome; Strahlentherapie des Basalzellkarzinoms. Lokale Kontrolle und kosmetisches Ergebnis

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H.; Oberste-Beulmann, S.; Guntrum, F.; Olschewski, T. [Krankenhaus Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Lang, E.; Lang, B. [Praxis fuer Dermatologie, Essen (Germany)

    2001-05-01

    Background: The basal cell carcinoma which is often occurring in the elderly can be well treated by surgery. For large and recurrent lesions and in cosmetically difficult locations external beam radiotherapy provides an equally effective treatment alternative. Patients and Methods: From 1986 to 1999, 60 females and 39 males received primary radiotherapy for a total of 127 histologically verified basal cell carcinoma lesions. Tumors were mostly localized in the face at the temple, nose and forehead. Radiotherapy was applied with orthovoltage equipment and energies of up to 100 kV. Single doses ranged from 2 to 5 Gy related to the 80%-isodose depth. Weekly doses ranged from 8 to 25 Gy and total doses from 25 to 60 Gy. The mean follow-up period was 36{+-}21 months. The acute sequelae were scored according to CTC criteria. Radiogenic late effects as single events were related to the radiation portal. Results: 3 months after treatment all besides one patient (99%) experienced complete tumor remission (CR). In all cases, acute radiation reaction occurred within the radiation portal: CTC Grade 1 in 100%, CTC Grade 2 in 54% and CTC Grade 3 in 30% of the cases. All side effects regressed under simple local measures without further complications. Late sequelae were observed in three cases. Overall cosmetic outcome was good to excellent in almost all patients (98%). In two cases (2%) a local recurrence was observed 6 and 20 months after radiotherapy. Conclusion: External beam (orthovoltage) radiotherapy is very effective and yields high tumor control rates and good cosmetic results in long-term follow-up. Former dermatological treatment concepts should be replaced by an ICRU-based radiophysical dose prescription and should respect the newer radiobiological fractionation principles. (orig.) [German] Hintergrund: Das Basaliom oder Basalzellkarzinom ist ein im Alter haeufig vorkommender Hauttumor, der chirurgisch gut behandelbar ist. Bei grossen und rezidivierenden Tumoren und

  17. The European Foundation for Quality Management (EFQM Excellence Model in a Low Voltage Switchgear Compan

    Directory of Open Access Journals (Sweden)

    Özgür Özmen

    2017-11-01

    Full Text Available The Turkish low voltage switchgear sector is made up of several local and international companies. Generally, local companies operating in this sector try to get a competitive advantage by fabricating cheap products, in order to cope with the competition that focuses more on quality. What’s more, international corporations perform quality activities under the organization and control of their top-managements from abroad. Although VIKO is a local producer, it is a company willing to invest more in quality, as well as in research and development. VIKO company is the focus of this self-assessment study, since it lies at the conjunction of companies operating in this sector, it being a local company performing various quality enhancement activities. Simultaneously, the authors consider that this study shall prove useful to create an overview over the entire Turkish low voltage switchgear sector. The evaluation of the company and its core-activities was based upon nine criteria of the European Foundation for Quality Management (EFQM Excellence Model, in order to identify the strengths, the weaknesses and aspects that require improvements. This is the first study worldwide performed in the low voltage switchgear sector and it is aimed at motivating other Turkish companies that operate in this sector to implement The European Foundation for Quality Management (EFQM Excellence Model in their TQM activities (Total Quality Management.

  18. Effect of transarterial chemoembolization with miriplatin plus epirubicin on local control of hepatocellular carcinoma: a retrospective comparison with miriplatin monotherapy

    Directory of Open Access Journals (Sweden)

    Hashimoto N

    2013-08-01

    Full Text Available Naoko Hashimoto,1 Jin Iwazawa,1 Shoichi Ohue,2 Takashi Mitani11Department of Radiology, Nissay Hospital, Nishiku, Osaka, Japan; 2Department of Radiology, Komatsu Hospital, Neyagawa, JapanObjective: We aimed to evaluate local tumor control after transarterial chemoembolization (TACE for hepatocellular carcinoma using miriplatin and low-dose epirubicin combination therapy.Methods: We retrospectively analyzed the records of patients who underwent TACE using miriplatin plus low-dose epirubicin (30 patients, 61 nodules, August 2011–March 2012 and control patients who underwent TACE using miriplatin alone (36 patients, 70 nodules, June 2010–July 2011. The local control rate was compared between the two groups using the Kaplan–Meier estimator and the log-rank test. Factors affecting local tumor recurrence were analyzed using multivariate logistic regression analysis. Treatment-related toxicity was evaluated using the Common Terminology Criteria for Adverse Events.Results: The local control rates at 6 months and 1 year were 87% and 65% for the miriplatin plus low-dose epirubicin group, and 61% and 43% for the miriplatin group, respectively. Local tumor control rates were significantly better in the miriplatin plus low-dose epirubicin group than in the miriplatin group (P = 0.038. Multivariate analysis showed that the addition of epirubicin was an independent factor associated with better local tumor control (hazard ratio 0.2, P = 0.001. Overall incidence rates for adverse events were not significantly different between the two groups.Conclusion: Additional usage of low-dose epirubicin for TACE using miriplatin improved local tumor control of hepatocellular carcinoma with adverse effects comparable to those observed with TACE using miriplatin alone.Keywords: combination therapy, local recurrence, liver, embolization, comparative study

  19. MASS TRANSFER CONTROL OF A BACKWARD-FACING STEP FLOW BY LOCAL FORCING- EFFECT OF REYNOLDS NUMBER

    Directory of Open Access Journals (Sweden)

    Zouhaier MEHREZ

    2011-01-01

    Full Text Available The control of fluid mechanics and mass transfer in separated and reattaching flow over a backward-facing step by a local forcing, is studied using Large Eddy Simulation (LES.To control the flow, the local forcing is realized by a sinusoidal oscillating jet at the step edge. The Reynolds number is varied in the range 10000 ≤ Re≤ 50000 and the Schmidt number is fixed at 1.The found results show that the flow structure is modified and the local mass transfer is enhanced by the applied forcing. The observed changes depend on the Reynolds number and vary with the frequency and amplitude of the local forcing. For the all Reynolds numbers, the largest recirculation zone size reduction is obtained at the optimum forcing frequency St = 0.25. At this frequency the local mass transfer enhancement attains the maximum.

  20. An Excel macro for generating trilinear plots.

    Science.gov (United States)

    Shikaze, Steven G; Crowe, Allan S

    2007-01-01

    This computer note describes a method for creating trilinear plots in Microsoft Excel. Macros have been created in MS Excel's internal language: Visual Basic for Applications (VBA). A simple form has been set up to allow the user to input data from an Excel worksheet. The VBA macro is used to convert the triangular data (which consist of three columns of percentage data) into X-Y data. The macro then generates the axes, labels, and grid for the trilinear plot. The X-Y data are plotted as scatter data in Excel. By providing this macro in Excel, users can create trilinear plots in a quick, inexpensive manner.

  1. Synthesis of control algorithms on-board information and control systems of aircraft at the minimum criterion of accesses to local memory

    Directory of Open Access Journals (Sweden)

    2015-01-01

    Full Text Available The technique of formation of the structure of the local memory on-Board information and control systems. Formalized the problem of choosing a set of programs to implement many of the algorithms and optimizing the structure of the local memory that belong to the class of problems of discrete programming with pseudoboolean variables. Based on the application of graph theory algorithms improve the efficient use of cache memory on-Board information and control systems.

  2. A local control strategy for power systems in transient emergency state; Part II - implementation and test results by stimulation

    Energy Technology Data Exchange (ETDEWEB)

    Aliyu, U.; El-Abiad, A.H.

    1982-11-01

    The functional design of a local control strategy considered suitable for bulk power system disturbed into transient emergency state was set forth in the companion paper. It utilized a particular control procedure based on an adaptively specified angle velocity threshold limit criteria. In order to consolidate the validity of the strategy, this paper describes its algorithmic implementation and discusses two extensive test results. The design philosophy and implementation of the proposed control framework are based on the hierachical control approach.

  3. Salvage brachytherapy in prostate local recurrence after radiation therapy: predicting factors for control and toxicity

    Science.gov (United States)

    2014-01-01

    Purpose To evaluate efficacy and toxicity after salvage brachytherapy (BT) in prostate local recurrence after radiation therapy. Methods and materials Between 1993 and 2007, we retrospectively analyzed 56 consecutively patients (pts) undergoing salvage brachytherapy. After local biopsy-proven recurrence, pts received 145 Gy LDR-BT (37 pts, 66%) or HDR-BT (19 pts, 34%) in different dose levels according to biological equivalent doses (BED2 Gy). By the time of salvage BT, only 15 pts (27%) received ADT. Univariate and multivariate analyses were performed to identify predictors of biochemical control and toxicities. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicities were graded using Common Terminology Criteria for Adverse Events (CTCv3.0). Results Median follow-up after salvage BT was 48 months. The 5-year FFbF was 77%. HDR and LDR late grade 3 GU toxicities were observed in 21% and 24%. Late grade 3 GI toxicities were observed in 2% (HDR) and 2.7% (LDR). On univariate analysis, pre-salvage prostate-specific antigen (PSA) > 10 ng/ml (p = 0.004), interval to relapse after initial treatment < 24 months (p = 0.004) and salvage HDR-BT doses BED2 Gy level < 227 Gy (p = 0.012) were significant in predicting biochemical failure. On Cox multivariate analysis, pre-salvage PSA, and time to relapse were significant in predicting biochemical failure. HDR-BT BED2 Gy (α/β 1.5 Gy) levels ≥ 227 (p = 0.013), and ADT (p = 0.049) were significant in predicting grade ≥ 2 urinary toxicity. Conclusions Prostate BT is an effective salvage modality in some selected prostate local recurrence patients after radiation therapy. Even, we provide some potential predictors of biochemical control and toxicity for prostate salvage BT, further investigation is recommended. PMID:24885287

  4. Local endometrial injury in women with failed IVF undergoing a repeat cycle: A randomized controlled trial.

    Science.gov (United States)

    Tk, Aleyamma; Singhal, Himanshu; S Premkumar, Prasanna; Acharya, Mousumi; S Kamath, Mohan; George, Korula

    2017-07-01

    To evaluate the effectiveness of local endometrial injury in women undergoing in vitro fertilization (IVF) with at least one previous unsuccessful attempt. Randomized controlled trial. Recruited women were randomized into two groups. In group A (pipelle group), women underwent pipelle biopsy twice in the luteal phase in the cycle prior to IVF. In group B (control), women did not undergo any intervention prior to IVF. The primary outcome was clinical pregnancy rate. The secondary outcomes included live birth, miscarriage, multiple pregnancy and preterm delivery rates. One hundred and eleven women were included in the study with 55 in the pipelle group and 56 in the control arm. The baseline clinical characteristics were similar in both groups. The clinical pregnancy rates were not significantly different between pipelle and control group (34.09% vs. 27.65%; Odds ratio, OR 1.35, 95% confidence interval, CI 0.55-3.30). The live birth (31.81% vs. 25.53%; OR 1.36, 95% CI 0.55-3.39), multiple pregnancy (33.33% vs. 61.54%; OR 0.31, 95% CI 0.07-1.47), miscarriage (6.66% vs. 7.69%; OR 0.86, 95% CI 0.05-15.23) and preterm delivery rates (35.71% vs. 66.66%; OR 0.28, 95% CI 0.05-1.4) were also not significantly different between the two groups. Current study did not find any improvement in IVF success rates following endometrial injury in woman undergoing IVF after previous failed attempt. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Adductor canal block with local infiltrative analgesia compared with local infiltrate analgesia for pain control after total knee arthroplasty

    Science.gov (United States)

    Xing, Qiujuan; Dai, Weiwei; Zhao, Dongfeng; Wu, Ji; Huang, Chunshui; Zhao, Yun

    2017-01-01

    Abstract Background: This meta-analysis aimed to evaluate the efficiency and safety of the combined adductor canal block with peri-articular infiltration versus periarticular infiltration alone for pain control after total knee arthroplasty (TKA). Methods: PubMed, Medline, Embase, Web of Science, and the Cochrane Library were searched to identify articles comparing the combined adductor canal block with peri-articular infiltration and periarticular infiltration alone for pain control after TKA. Main outcomes were numeric rating scale (NRS) at postoperative day (POD) 0–2 and opioid consumption. Meta-analysis was performed using Stata 11.0 software. Results: Four randomized controlled trial (RCTs) including 297 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between the groups regarding NRS score at POD 0 (weighted mean difference [WMD] = −0.849, 95% confidence interval [CI]: −1.345 to −0.353, P = .001), POD 1 (WMD = −0.960, 95% CI: −1.474 to −0.446, P = .000), and POD 2 (WMD = −0.672, 95% CI: −1.163 to −0.181, P = .007) after TKA. Significant differences were found in terms of opioid consumption at POD 0 (WMD = −3.761, 95% CI: −6.192 to −1.329, P = .002), POD 1 (WMD = −4.795, 95% CI: −8.181 to −1.409, P = .006), and POD 2 (WMD = −2.867, 95% CI: −4.907 to −0.827, P = .006). Conclusion: Combined adductor canal block with peri-articular infiltration could significantly reduce NRS scores and opioid consumption in comparison with periarticular infiltration alone following TKA. Additionally, there is a lower incidence of nausea and vomiting in the combined groups. PMID:28930857

  6. Local control and intermediate-term cosmetic outcome following IMRT for nasal tumors. An update

    Energy Technology Data Exchange (ETDEWEB)

    Mukai, Yuki [University Hospital Zurich, Department of Radiation Oncology, Head Neck Cancer Center, Zurich (Switzerland); Yokohama City University Graduate School of Medicine, Department of Radiology, Yokohama (Japan); Janssen, Stefan [University Hospital Zurich, Department of Radiation Oncology, Head Neck Cancer Center, Zurich (Switzerland); Glanzmann, Christoph; Studer, Gabriela [University Hospital Zurich, Department of Radiation Oncology, Head Neck Cancer Center, Zurich (Switzerland); Cantonal Hospital Lucerne, Institute for Radiation Oncology, Lucerne (Switzerland); Holzmann, David [University Hospital Zurich, Department of Otorhinolaryngology, Head and Neck Surgery, Head Neck Cancer Center, Zurich (Switzerland)

    2017-04-15

    This study aims to evaluate local control and intermediate-term cosmetic outcome in patients with cancer of the nose treated with intensity-modulated radiotherapy (IMRT). From June 2008 to September 2015, 36 consecutive patients presenting with nasal cavity, ala of the nose, or nasal vestibule tumors were treated at the Department of Radiation Oncology, University Hospital Zurich either postoperatively (n = 14; 3/14 with nasal ablation) or with definitive IMRT (n = 22). Of these 36 patients, 8 presented with recurrent disease after surgery only and 1/36 with N1 disease. Concurrent systemic therapy was administered in 18/36 patients (50%). Nasal follow-up (FU) imaging documentation of 13 patients with preserved organ and >6 months FU offers a pre/post IMRT FU comparison. In addition, these patients' subjective evaluation of cosmesis was assessed. Mean/median FU was 41/33 months (range 5-92 months). Salvage ablation with curative intent was undergone by 3 patients with local relapse after definitive (n = 2) and postoperative (n = 1) IMRT. The 3-year local control, ultimate local control, and overall survival rates were 90, 97, and 90 %, respectively. Subjective and objective cosmetic outcome after IMRT is very satisfying so far. IMRT for nasal tumors was found to be effective and well tolerated. Intermediate-term cosmetic results are good. Radical surgical procedures may be saved for curative salvage treatment. (orig.) [German] Evaluation der Lokalkontrolle und des mittelfristigen kosmetischen Resultats nach intensitaetsmodulierter Radiotherapie (IMRT) von Patienten mit Nasentumoren. Von Juni 2008 bis September 2015 wurden an der Klinik fuer RadioOnkologie am UniversitaetsSpital Zuerich 36 konsekutive Patienten mit Tumoren der Nasenhoehle, der Nasenfluegel oder des Vestibulum nasi postoperativ (n = 14; 3/14 nach Nasenablation) oder definitiv IMRT-bestrahlt (n = 22). Von diesen 36 Patienten zeigten 8 ein Lokalrezidiv nach alleiniger vorangegangener Chirurgie und

  7. Autologous whole blood versus corticosteroid local injection in treatment of plantar fasciitis: A randomized, controlled multicenter clinical trial.

    Science.gov (United States)

    Karimzadeh, Afshin; Raeissadat, Seyed Ahmad; Erfani Fam, Saleh; Sedighipour, Leyla; Babaei-Ghazani, Arash

    2017-03-01

    Plantar fasciitis is the most common cause of heel pain. Local injection modalities are among treatment options in patients with resistant pain. The aim of the present study was to evaluate the effect of local autologous whole blood compared with corticosteroid local injection in treatment of plantar fasciitis. In this randomized controlled multicenter study, 36 patients with chronic plantar fasciitis were recruited. Patients were allocated randomly into three treatment groups: local autologous blood, local corticosteroid injection, and control groups receiving no injection. Patients were assessed with visual analog scale (VAS), pressure pain threshold (PPT), and plantar fasciitis pain/disability scale (PFPS) before treatment, as well as 4 and 12 weeks post therapy. Variables of pain and function improved significantly in both corticosteroid and autologous blood groups compared to control group. At 4 weeks following treatment, patients in corticosteroid group had significantly lower levels of pain than patients in autologous blood and control groups (higher PPT level, lower PFPS, and VAS). After 12 weeks of treatment, both corticosteroid and autologous blood groups had lower average levels of pain than control group. The corticosteroid group showed an early sharp and then more gradual improvement in pain scores, but autologous blood group had a steady gradual drop in pain. Autologous whole blood and corticosteroid local injection can both be considered as effective methods in the treatment of chronic plantar fasciitis. These treatments decrease pain and significantly improve function compared to no treatment.

  8. Surgical model-view-controller simulation software framework for local and collaborative applications.

    Science.gov (United States)

    Maciel, Anderson; Sankaranarayanan, Ganesh; Halic, Tansel; Arikatla, Venkata Sreekanth; Lu, Zhonghua; De, Suvranu

    2011-07-01

    Surgical simulations require haptic interactions and collaboration in a shared virtual environment. A software framework for decoupled surgical simulation based on a multi-controller and multi-viewer model-view-controller (MVC) pattern was developed and tested. A software framework for multimodal virtual environments was designed, supporting both visual interactions and haptic feedback while providing developers with an integration tool for heterogeneous architectures maintaining high performance, simplicity of implementation, and straightforward extension. The framework uses decoupled simulation with updates of over 1,000 Hz for haptics and accommodates networked simulation with delays of over 1,000 ms without performance penalty. The simulation software framework was implemented and was used to support the design of virtual reality-based surgery simulation systems. The framework supports the high level of complexity of such applications and the fast response required for interaction with haptics. The efficacy of the framework was tested by implementation of a minimally invasive surgery simulator. A decoupled simulation approach can be implemented as a framework to handle simultaneous processes of the system at the various frame rates each process requires. The framework was successfully used to develop collaborative virtual environments (VEs) involving geographically distributed users connected through a network, with the results comparable to VEs for local users.

  9. Extraction and localization of mesoscopic motor control signals for human ECoG neuroprosthetics.

    Science.gov (United States)

    Sanchez, Justin C; Gunduz, Aysegul; Carney, Paul R; Principe, Jose C

    2008-01-15

    Electrocorticogram (ECoG) recordings for neuroprosthetics provide a mesoscopic level of abstraction of brain function between microwire single neuron recordings and the electroencephalogram (EEG). Single-trial ECoG neural interfaces require appropriate feature extraction and signal processing methods to identify and model in real-time signatures of motor events in spontaneous brain activity. Here, we develop the clinical experimental paradigm and analysis tools to record broadband (1Hz to 6kHz) ECoG from patients participating in a reaching and pointing task. Motivated by the significant role of amplitude modulated rate coding in extracellular spike based brain-machine interfaces (BMIs), we develop methods to quantify spatio-temporal intermittent increased ECoG voltages to determine if they provide viable control inputs for ECoG neural interfaces. This study seeks to explore preprocessing modalities that emphasize amplitude modulation across frequencies and channels in the ECoG above the level of noisy background fluctuations in order to derive the commands for complex, continuous control tasks. Preliminary experiments show that it is possible to derive online predictive models and spatially localize the generation of commands in the cortex for motor tasks using amplitude modulated ECoG.

  10. Fowl Cholera and Its Control Prospect With Locally isolated Pasteurella multocida Bivalent Vaccines

    Directory of Open Access Journals (Sweden)

    Tati Ariyanti

    2008-03-01

    Full Text Available Pasteurellosis or fowl cholera disease which associated with Pasteurella multocida group A and D infections occurred sporadically in many parts of the world, including in Indonesia. The pathogenic activity of P. multocida in chickens were based on lipopolysacharide (LPS antigens associated with group A and D capsules, and the resistance factor of complement mediated bacteriolysis in animals. In order to reduce common bacterial infections, antibiotics were routinely used as feed additive or by drinking water, but fowl cholera cases still occur. Fowl cholera control by vaccinations have been used more than a hundred years ago by means of inactive vaccine, but imported inactive vaccine was reported not effective due to lack of cross protection against heterologous serotype. At present, many local P. multocida isolates from chicken and ducks from many areas in Indonesia were characterised for their antigenicity, immunogenicity and prepared as monovalent or bivalent vaccine. Only the monovalent vaccine prepared from BCC 2331 or DY2 demonstrated the presence of immunoprotection against homologous and heterologous challenged with live bacteria. The prototype bivalent vaccine consisting of BCC 2331 + DY2 demonstrated high degree of cross protection against challenged individual with or mixed of BCC 2331 + DY2 at average of 60 – 75% and 75 – 100%, respectively. Monovalent and bivalent vaccine prepared from other isolates including imported reference strains of P. multocida demonstrated no protection in experimentally vaccinated ducks and chicken against challenged with live bacteria of neither BCC 2331 nor with DY2. From these retrospective studies, it was concluded that the local isolates P. multocida designated as BCC 2331 and DY2 could be used as candidates of prototype vaccine or master seed vaccine but their effectiveness still need to be evaluated under field conditions.

  11. Local governments and civil society lead breakthrough for tobacco control: lessons from Chandigarh and Chennai.

    Science.gov (United States)

    Kashiwabara, Mina; Arul, Rathinum; Goswami, Hemant; Narain, Jai P; Armada, Francisco

    2011-01-01

    Smoke-free legislation is gaining popularity; however, it must accompany effective implementation to protect people from secondhand smoke (SHS) which causes 600,000 deaths annually. Increasing numbers of smoke-free cities in the world indicate that municipalities have an important role in promoting smoke-free environments. The objectives were to describe the local initiative to promote smoke-free environments and identify the key factors that contributed to the process. Observations were based on a case study on the municipal smoke-free initiatives in Chandigarh and Chennai, India. India adopted the Cigarette and Other Tobacco Products Act in 2003, the first national tobacco control law including smoke-free provisions. In an effort to enforce the Act at the local level, a civil society organization in Chandigarh initiated activities urging the city to support the implementation of the provisions of the Act which led to the initiation of city-wide law enforcement. After the smoke-free declaration of Chandigarh in 2007, Chennai also initiated a smoke-free intervention led by civil society in 2008, following the strategies used in Chandigarh. These experiences resonate with other cases in Asian cities, such as Jakarta, Davao, and Kanagawa as well as cities in other areas of the world including Mexico City, New York City, Mecca and Medina. The cases of Chandigarh and Chennai demonstrate that civil society can make a great contribution to the enforcement of smoke-free laws in cities, and that cities can learn from their peers to protect people from SHS.

  12. Regional and local networks of horizontal control, Cerro Prieto geothermal area

    Science.gov (United States)

    Massey, B.L.

    1979-01-01

    The Cerro Prieto geothermal area in the Mexicali Valley 30 km southeast of Mexicali, Baja California, is probably deforming due to (1) the extraction of large volumes of steam and hot water, and (2) active tectonism. Two networks of precise horizontal control were established in Mexicali Valley by the U.S. Geological Survey in 1977 - 1978 to measure both types of movement as they occur. These networks consisted of (1) a regional trilateration net brought into the mountain ranges west of the geothermal area from survey stations on an existing U.S. Geological Survey crustal-strain network north of the international border, and (2) a local net tied to stations in the regional net and encompassing the area of present and planned geothermal production. Survey lines in this net were selected to span areas of probable ground-surface movements in and around the geothermal area. Electronic distance measuring (EDM) instruments, operating with a modulated laser beam, were used to measure the distances between stations in both networks. The regional net was run using a highly precise long-range EDM instrument, helicopters for transportation of men and equipment to inaccessible stations on mountain peaks, and a fixed wing airplane flying along the line of sight. Precision of measurements with this complex long-range system approached 0-2 ppm of line length. The local net was measured with a medium-range EDM instrument requiring minimal ancillary equipment. Precision of measurements with this less complex system approached 3 ppm for the shorter line lengths. The detection and analysis of ground-surface movements resulting from tectonic strains or induced by geothermal fluid withdrawal is dependent on subsequent resurveys of these networks. ?? 1979.

  13. Ductal Carcinoma in Situ-The Influence of the Radiotherapy Boost on Local Control

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Philip [Division of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Lambert, Christine, E-mail: christine.lambert@muhc.mcgill.ca [Division of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Agnihotram, Ramanakumar V. [Division of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC (Canada); David, Marc; Duclos, Marie; Freeman, Carolyn R. [Division of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada)

    2012-02-01

    Purpose: Local recurrence (LR) of ductal carcinoma in situ (DCIS) is reduced by whole-breast irradiation after breast-conserving surgery (BCS). However, the benefit of adding a radiotherapy boost to the surgical cavity for DCIS is unclear. We sought to determine the impact of the boost on LR in patients with DCIS treated at the McGill University Health Centre. Methods and Materials: A total of 220 consecutive cases of DCIS treated with BCS and radiotherapy between January 2000 and December 2006 were reviewed. Of the patients, 36% received a radiotherapy boost to the surgical cavity. Median follow-up was 46 months for the boost and no-boost groups. Kaplan-Meier survival analyses and Cox regression analyses were performed. Results: Compared with the no-boost group, patients in the boost group more frequently had positive and <0.1-cm margins (48% vs. 8%) (p < 0.0001) and more frequently were in higher-risk categories as defined by the Van Nuys Prognostic (VNP) index (p = 0.006). Despite being at higher risk for LR, none (0/79) of the patients who received a boost experienced LR, whereas 8 of 141 patients who did not receive a boost experienced an in-breast LR (log-rank p = 0.03). Univariate analysis of prognostic factors (age, tumor size, margin status, histological grade, necrosis, and VNP risk category) revealed only the presence of necrosis to significantly correlate with LR (log-rank p = 0.003). The whole-breast irradiation dose and fractionation schedule did not affect LR rate. Conclusions: Our results suggest that the use of a radiotherapy boost improves local control in DCIS and may outweigh the poor prognostic effect of necrosis.

  14. Effect of local anesthesia on atypical odontalgia--a randomized controlled trial.

    Science.gov (United States)

    List, Thomas; Leijon, Göran; Helkimo, Martti; Oster, Anders; Svensson, Peter

    2006-06-01

    The aim of the study was to evaluate the analgesic effect of lidocaine in a double-blind, controlled multi-center study on patients with atypical odontalgia (AO)--a possible orofacial neuropathic pain condition. Thirty-five consecutive AO patients (range 31-81 years) with a mean pain duration of 7.2 years (range 1-30 years) were recruited from four different orofacial pain clinics in Sweden. In a randomized cross-over design, 1.5 ml local anesthesia (20mg/ml lidocaine and 12.5 microg/ml adrenaline) or 1.5 ml saline (9 mg/ml NaCl solution) (placebo) was injected to block the painful area. The VAS pain scores showed an overall effect of time (ANOVA: P<0.001) and treatment (ANOVA: P=0.018) with a significant interaction between the factors (ANOVA: P<0.001). Overall, VAS pain relief was significantly greater at 15-120 min following the lidocaine injections compared to the placebo injections (Tukey: P<0.05). All patients demonstrated significant disturbances in somatosensory function on the painful side compared to the non-painful side as revealed by quantitative sensory tests, however, only one significant inverse correlation was found between percentage pain relief and the magnitude of brush-evoked allodynia (Spearman: P<0.01). In conclusion, AO patients experienced significant, but not complete, pain relief from administration of local anesthetics compared with placebo. The findings indicate that the spontaneous pain in AO patients only to some extent is dependent on peripheral afferent inputs and that sensitization of higher order neurons may be involved in the pathophysiology of AO.

  15. Measuring research excellence in the EU

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Bloch, Carter Walter; Young, Mitchell

    In 2013, the European Union unveiled its new ‘Composite Indicator for Scientific and Technological Research Excellence’, marking a turning point in how excellence is understood and used in European policy. This is not an isolated occurrence; policy-based interest in excellence is growing all over...... the world. The heightened focus on excellence and in particular, attempts to define it through quantitative indicators can have important implications for research policy and for the conduct of research itself. This paper examines how the European Union’s understanding of excellence has evolved in recent...... years, from the presentation of the Lisbon strategy in 2000 to the current Europe 2020 strategy. We find a distinct shift in the understanding of excellence and how success in the knowledge-based economy should be achieved: in the early period, excellence is a fuzzy concept, intrinsically embedded...

  16. Local Nordic tobacco interests collaborated with multinational companies to maintain a united front and undermine tobacco control policies

    Science.gov (United States)

    Hiilamo, Heikki; Glantz, Stanton A

    2012-01-01

    Objective To analyse how local tobacco companies in the Nordic countries, individually and through National Manufacturers’ Associations, cooperated with British American Tobacco and Philip Morris in denying the health hazards of smoking and undermining tobacco control. Methods Analysis of tobacco control policies in the Nordic countries and tobacco industry documents. Results Nordic countries were early adopters of tobacco control policies. The multinational tobacco companies recognised this fact and mobilised to oppose these policies, in part because of fear that they would set unfavourable precedents. Since at least 1972, the Nordic tobacco companies were well informed about and willing to participate in the multinational companies activities to obscure the health dangers of smoking and secondhand smoke and to oppose tobacco control policies. Cooperation between multinational companies, Nordic national manufacturer associations and local companies ensured a united front on smoking and health issues in the Nordic area that was consistent with the positions that the multinational companies were taking. This cooperation delayed smoke-free laws and undermined other tobacco control measures. Conclusions Local tobacco companies worked with multinational companies to undermine tobacco control in distant and small Nordic markets because of concern that pioneering policies initiated in Nordic countries would spread to bigger market areas. Claims by the local Nordic companies that they were not actively involved with the multinationals are not supported by the facts. These results also demonstrate that the industry appreciates the global importance of both positive and negative public health precedents in tobacco control. PMID:22199013

  17. Local Nordic tobacco interests collaborated with multinational companies to maintain a united front and undermine tobacco control policies.

    Science.gov (United States)

    Hiilamo, Heikki; Glantz, Stanton A

    2013-03-01

    To analyse how local tobacco companies in the Nordic countries, individually and through National Manufacturers' Associations, cooperated with British American Tobacco and Philip Morris in denying the health hazards of smoking and undermining tobacco control. Analysis of tobacco control policies in the Nordic countries and tobacco industry documents. Nordic countries were early adopters of tobacco control policies. The multinational tobacco companies recognised this fact and mobilised to oppose these policies, in part because of fear that they would set unfavourable precedents. Since at least 1972, the Nordic tobacco companies were well informed about and willing to participate in the multinational companies activities to obscure the health dangers of smoking and secondhand smoke and to oppose tobacco control policies. Cooperation between multinational companies, Nordic national manufacturer associations and local companies ensured a united front on smoking and health issues in the Nordic area that was consistent with the positions that the multinational companies were taking. This cooperation delayed smoke-free laws and undermined other tobacco control measures. Local tobacco companies worked with multinational companies to undermine tobacco control in distant and small Nordic markets because of concern that pioneering policies initiated in Nordic countries would spread to bigger market areas. Claims by the local Nordic companies that they were not actively involved with the multinationals are not supported by the facts. These results also demonstrate that the industry appreciates the global importance of both positive and negative public health precedents in tobacco control.

  18. The Emergence and Impact of MNC Centres of Excellence

    DEFF Research Database (Denmark)

    Holm, Ulf; Pedersen, Torben

    other in a complicated pattern. One crucial aspect of this is that some subsidiaries become "Centres of Excellence" (COE) controlling resources on which other parts of the corporation depend for their operations. This work investigates the existence of COEs in different countries, examining why...... they emerge and analysing their impact on corporate strategy. In the development of the multinational corporation different subsidiaries have different roles, and some become "Centres of Excellence" (COE) controlling resources on which other parts of the corporation depend. This work investigates COEs...

  19. An adaptive PID like controller using mix locally recurrent neural network for robotic manipulator with variable payload.

    Science.gov (United States)

    Sharma, Richa; Kumar, Vikas; Gaur, Prerna; Mittal, A P

    2016-05-01

    Being complex, non-linear and coupled system, the robotic manipulator cannot be effectively controlled using classical proportional-integral-derivative (PID) controller. To enhance the effectiveness of the conventional PID controller for the nonlinear and uncertain systems, gains of the PID controller should be conservatively tuned and should adapt to the process parameter variations. In this work, a mix locally recurrent neural network (MLRNN) architecture is investigated to mimic a conventional PID controller which consists of at most three hidden nodes which act as proportional, integral and derivative node. The gains of the mix locally recurrent neural network based PID (MLRNNPID) controller scheme are initialized with a newly developed cuckoo search algorithm (CSA) based optimization method rather than assuming randomly. A sequential learning based least square algorithm is then investigated for the on-line adaptation of the gains of MLRNNPID controller. The performance of the proposed controller scheme is tested against the plant parameters uncertainties and external disturbances for both links of the two link robotic manipulator with variable payload (TL-RMWVP). The stability of the proposed controller is analyzed using Lyapunov stability criteria. A performance comparison is carried out among MLRNNPID controller, CSA optimized NNPID (OPTNNPID) controller and CSA optimized conventional PID (OPTPID) controller in order to establish the effectiveness of the MLRNNPID controller. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  20. What every engineer should know about excel

    CERN Document Server

    Holman, J P

    2006-01-01

    INTRODUCTIONGetting the Most from ExcelConventionsOutline of MISCELLANEOUS OPERATIONS IN EXCEL AND WORDIntroductionPrint Screen or Screen DumpCustom Keyboard Setup for Symbols in WordViewing or Printing Column and Row Headings and Gridlines in ExcelAssorted InstructionsMoving Objects in Small Increments (Nudging)Formatting Objects in Word, Including WrappingFormatting Objects in ExcelUse of Photo-Editing Software in Word, Including WrappingCopying Cell Formulas: Effect of Relative and Absolute AddressesCopying Formulas by Dragging the Fill HandleShortcut for Changing the Status of Cell Address

  1. Excel 2013 power programming with VBA

    CERN Document Server

    Walkenbach, John

    2013-01-01

    Maximize your Excel 2013 experience using VBA application development The new Excel 2013 boasts updated features, enhanced power, and new capabilities. Naturally, that means John Walkenbach returns with a new edition of his bestselling VBA Programming book and covers all the methods and tools you need to know in order to program with Excel. With this comprehensive guide, ""Mr. Spreadsheet"" shows you how to maximize your Excel experience using professional spreadsheet application development tips from his own personal bookshelf. Featuring a complete introduction to Visual Basic f

  2. Excel 2003 Power Programming with VBA

    CERN Document Server

    Walkenbach, John

    2008-01-01

    "Today, no accomplished Excel programmer can afford to be without John's book. The value of Excel 2003 Power Programming with VBA is double most other books-simultaneously the premier reference and best learning tool for Excel VBA."--Loren Abdulezer, Author of Excel Best Practices for BusinessEverything you need to know about:* Creating stellar UserForms and custom dialog box alternatives * Working with VBA subprocedures and function procedures * Incorporating event-handling and interactions with other applications * Building user-friendly toolbars, menus, and help systems * Manipulating files

  3. Technical Excellence: A Requirement for Good Engineering

    Science.gov (United States)

    Gill, Paul S.; Vaughan, William W.

    2008-01-01

    Technical excellence is a requirement for good engineering. Technical excellence has many different ways of expressing itself within engineering. NASA has initiatives that address the enhancement of the Agency's technical excellence and thrust to maintain the associated high level of performance by the Agency on current programs/projects and as it moves into the Constellation Program and the return to the Moon with plans to visit Mars. This paper addresses some of the key initiatives associated with NASA's technical excellence thrust. Examples are provided to illustrate some results being achieved and plans to enhance these initiatives.

  4. Performance management system as a tool for promoting effective waste control : the case of Emfuleni Local Municipality / Sipho J. Ngwenya

    OpenAIRE

    Ngwenya, Sipho Jeffrey

    2014-01-01

    This study aimed at evaluating the degree to which Performance Management System is being executed at Waste Management Unit within the Emfuleni Local Municipality hence the topic “Performance Management System as a tool for promoting effective waste control: The case of the Emfuleni Local Municipality.” The Performance Management System issues a structure for establishing development needs, determining suitable resources, and making the recommendations regarding suitable PMS of which managers...

  5. Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization.

    Science.gov (United States)

    Ji, Yingbiao; Tulin, Alexei V

    2012-03-27

    Within the short span of the cell cycle, poly(ADP-ribose) (pADPr) can be rapidly produced by poly(ADP-ribose) polymerases and degraded by poly(ADP-ribose) glycohydrolases. Here we show that changes in association between pADPr and heterogeneous nuclear ribonucleoproteins (hnRNPs) regulate germline stem cell (GSC) maintenance and egg chamber polarity during oogenesis in Drosophila. The association of pADPr and Hrp38, an orthologue of human hnRNPA1, disrupts the interaction of Hrp38 with the 5'-untranslated region of DE-cadherin messenger RNA, thereby diminishing DE-cadherin translation in progenitor cells. Following the reduction of DE-cadherin level, GSCs leave the stem cell niche and differentiate. Defects in either pADPr catabolism or Hrp38 function cause a decrease in DE-cadherin translation, leading to a loss of GSCs and mislocalization of oocytes in the ovary. Taken together, our findings suggest that Hrp38 and its association with pADPr control GSC self-renewal and oocyte localization by regulating DE-cadherin translation.

  6. Influence of number of CAG repeats on local control in the RTOG 86-10 protocol.

    Science.gov (United States)

    Abdel-Wahab, May; Berkey, Brian A; Krishan, Awtar; O'Brien, Tom; Hammond, Elizabeth; Roach, Mack; Lawton, Colleen; Pilepich, Milijenko; Markoe, Arnold; Pollack, Alan

    2006-02-01

    The number of CAG repeats on the androgen receptor (AR) gene is inversely proportional to transcriptional activity. The purpose of this study was to determine if short-term androgen deprivation therapy (RT + HT) can improve outcome in patients with tumors with short CAG repeats (LF), distant metastases (DM), prostate cancer survival (PSS), and overall survival (OS) was studied. Pretreatment characteristics and assigned treatment arm were not significantly different between the parent and test groups except for a significantly higher risk of death (P = 0.049) in the test group. The median CAG repeat was 19. There were no significant differences in stage, or Gleason score between high (19 or greater) and low CAG (LF, DM, PSS, and OS. However, when the CAG repeat outcome was studied in conjunction with androgen deprivation therapy, patients with CAG or =19 that received H + RT (P = 0.028). Patients with short CAG repeats show a local control benefit with short-term androgen deprivation therapy, but no improvement in survival.

  7. SLK-dependent activation of ERMs controls LGN–NuMA localization and spindle orientation

    Science.gov (United States)

    Machicoane, Mickael; de Frutos, Cristina A.; Fink, Jenny; Rocancourt, Murielle; Lombardi, Yannis; Garel, Sonia; Piel, Matthieu

    2014-01-01

    Mitotic spindle orientation relies on a complex dialog between the spindle microtubules and the cell cortex, in which F-actin has been recently implicated. Here, we report that the membrane–actin linkers ezrin/radixin/moesin (ERMs) are strongly and directly activated by the Ste20-like kinase at mitotic entry in mammalian cells. Using microfabricated adhesive substrates to control the axis of cell division, we found that the activation of ERMs plays a key role in guiding the orientation of the mitotic spindle. Accordingly, impairing ERM activation in apical progenitors of the mouse embryonic neocortex severely disturbed spindle orientation in vivo. At the molecular level, ERM activation promotes the polarized association at the mitotic cortex of leucine-glycine-asparagine repeat protein (LGN) and nuclear mitotic apparatus (NuMA) protein, two essential factors for spindle orientation. We propose that activated ERMs, together with Gαi, are critical for the correct localization of LGN–NuMA force generator complexes and hence for proper spindle orientation. PMID:24958772

  8. The Rate-Controlled Constrained-Equilibrium Approach to Far-From-Local-Equilibrium Thermodynamics

    Directory of Open Access Journals (Sweden)

    Hameed Metghalchi

    2012-01-01

    Full Text Available The Rate-Controlled Constrained-Equilibrium (RCCE method for the description of the time-dependent behavior of dynamical systems in non-equilibrium states is a general, effective, physically based method for model order reduction that was originally developed in the framework of thermodynamics and chemical kinetics. A generalized mathematical formulation is presented here that allows including nonlinear constraints in non-local equilibrium systems characterized by the existence of a non-increasing Lyapunov functional under the system’s internal dynamics. The generalized formulation of RCCE enables to clarify the essentials of the method and the built-in general feature of thermodynamic consistency in the chemical kinetics context. In this paper, we work out the details of the method in a generalized mathematical-physics framework, but for definiteness we detail its well-known implementation in the traditional chemical kinetics framework. We detail proofs and spell out explicit functional dependences so as to bring out and clarify each underlying assumption of the method. In the standard context of chemical kinetics of ideal gas mixtures, we discuss the relations between the validity of the detailed balance condition off-equilibrium and the thermodynamic consistency of the method. We also discuss two examples of RCCE gas-phase combustion calculations to emphasize the constraint-dependent performance of the RCCE method.

  9. Treatment of localized gingival recessions using gingival unit grafts: a randomized controlled clinical trial.

    Science.gov (United States)

    Kuru, Bahar; Yıldırım, Selin

    2013-01-01

    One of the success factors in periodontal plastic surgery is the synergistic relationship between involved tissues and vascular supply. Gingiva as a functional unit is unique with a specific vascular configuration and contains the supracrestal portion naturally created to survive over avascular root surfaces. The aim of this randomized controlled trial is to clinically evaluate the treatment of localized gingival recessions by using gingival unit grafts (palatal tissue involving marginal gingiva and papillae) compared with conventional palatal grafts. Seventeen patients with Class I to II recession defects on mandibular anterior teeth were included and randomly divided into two groups. Recessions were treated with gingival unit grafts in group 1 (n = 8) and with palatal grafts in group 2 (n = 9). Clinical parameters including vertical recession (VR), probing depth, keratinized tissue (KT), and attachment level were recorded at baseline and 8 months after surgery. Both treatments produced significant clinical improvements within the groups. Intergroup comparison revealed significantly higher VR reduction, attachment, and KT gain in group 1 than in group 2; mean percentages of the defect coverage were 91.62% ± 9.74% and 68.97% ± 13.67%, respectively (P <0.05). Healing of the gingival unit donor site was uneventful. Within its limits, this study demonstrates the possibility of treating buccal recessions with gingival unit grafts as an alternative technique using gingival donor graft of site-specific vascular configuration, with better defect coverage, clinical, and esthetic improvements compared with palatal grafts.

  10. Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.

    Science.gov (United States)

    Harris, Thurl E; Huffman, Todd A; Chi, An; Shabanowitz, Jeffrey; Hunt, Donald F; Kumar, Anil; Lawrence, John C

    2007-01-05

    Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy (fld/fld) mice, which do not express lipin 1 (lipin), contained much less Mg(2+)-dependent phosphatidic acid phosphatase (PAP) activity than tissues from wild type mice. Lipin harboring the fld(2j) (Gly(84) --> Arg) mutation exhibited relatively little PAP activity. These results indicate that lipin is a major PAP in vivo and that the loss of PAP activity contributes to the fld phenotype. PAP activity was readily detected in immune complexes of lipin from 3T3-L1 adipocytes, where the protein was found both as a microsomal form and a soluble, more highly phosphorylated, form. Fifteen phosphorylation sites were identified by mass spectrometric analyses. Insulin increased the phosphorylation of multiple sites and promoted a gel shift that was due in part to phosphorylation of Ser(106). In contrast, epinephrine and oleic acid promoted dephosphorylation of lipin. The PAP-specific activity of lipin was not affected by the hormones or by dephosphorylation of lipin with protein phosphatase 1. However, the ratio of soluble to microsomal lipin was markedly increased in response to insulin and decreased in response to epinephrine and oleic acid. The results suggest that insulin and epinephrine control lipin primarily by changing localization rather than intrinsic PAP activity.

  11. Local correlations for flap gap oscillatory blowing active flow control technology

    Directory of Open Access Journals (Sweden)

    Cătălin NAE

    2010-09-01

    Full Text Available Active technology for oscillatory blowing in the flap gap has been tested at INCAS subsonic wind tunnel in order to evaluate this technology for usage in high lift systems with active flow control. The main goal for this investigation was to validate TRL level 4 for this technology and to extend towards flight testing. CFD analysis was performed in order to identify local correlations with experimental data and to better formulate a design criteria so that a maximum increase in lift is possible under given geometrical constraints. Reference to a proposed metric for noise evaluation is also given. This includes basic 2D flow cases and also 2.5D configurations. In 2.5D test cases this work has been extended so that the proposed system may be selected as a mature technology in the JTI Clean Sky, Smart Fixed Wing Aircraft ITD. Complex post-processing of the experimental and CFD data was mainly oriented towards system efficiency and TRL evaluation for this active technology.

  12. Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study.

    Science.gov (United States)

    Sturdza, Alina; Pötter, Richard; Fokdal, Lars Ulrik; Haie-Meder, Christine; Tan, Li Tee; Mazeron, Renaud; Petric, Primoz; Šegedin, Barbara; Jurgenliemk-Schulz, Ina Maria; Nomden, Christel; Gillham, Charles; McArdle, Orla; Van Limbergen, Erik; Janssen, Hilde; Hoskin, Peter; Lowe, Gerry; Tharavichitkul, Ekkasit; Villafranca, Elena; Mahantshetty, Umesh; Georg, Petra; Kirchheiner, Kathrin; Kirisits, Christian; Tanderup, Kari; Lindegaard, Jacob Christian

    2016-09-01

    Image guided brachytherapy (IGBT) for locally advanced cervical cancer allows dose escalation to the high-risk clinical target volume (HRCTV) while sparing organs at risk (OAR). This is the first comprehensive report on clinical outcome in a large multi-institutional cohort. From twelve centres 731 patients, treated with definitive EBRT±concurrent chemotherapy followed by IGBT, were analysed. Kaplan-Meier estimates at 3/5years were calculated for local control (LC, primary endpoint), pelvic control (PC), overall survival (OS), cancer specific survival (CSS). In 610 patients, G3-4 late toxicity (CTCAEv3.0) was reported. Median follow up was 43months, percent of patients per FIGO stage IA/IB/IIA 22.8%, IIB 50.4%, IIIA-IVB 26.8%. 84.8% had squamous cell carcinomas; 40.5% lymph node involvement. Mean EBRT dose was 46±2.5Gy; 77.4% received concurrent chemotherapy. Mean D90 HRCTV was 87±15Gy (EQD2 10 ), mean D2cc was: bladder 81±22Gy, rectum 64±9Gy, sigmoid 66±10Gy and bowel 64±9Gy (all EQD2 3 ). The 3/5-year actuarial LC, PC, CSS, OS were 91%/89%, 87%/84%, 79%/73%, 74%/65%. Actuarial LC at 3/5years for IB, IIB, IIIB was 98%/98%, 93%/91%, 79%/75%. Actuarial PC at 3/5years for IB, IIB, IIIB was 96%/96%, 89%/87%, 73%/67%. Actuarial 5-year G3-G5 morbidity was 5%, 7%, 5% for bladder, gastrointestinal tract, vagina. IGBT combined with radio-chemotherapy leads to excellent LC (91%), PC (87%), OS (74%), CSS (79%) with limited severe morbidity. Copyright © 2016. Published by Elsevier Ireland Ltd.

  13. Smart Control of Air Climatization System in Function on the Values of Mean Local Radiant Temperature

    Directory of Open Access Journals (Sweden)

    Giuseppe Cannistraro

    2015-08-01

    Full Text Available The hygrothermal comfort indoor conditions are defined as: those environmental conditions in which an individual exposed, expresses a state of satisfaction. These conditions cannot always be achieved anywhere in an optimal way and economically; in some cases they can be obtained only in work environments specific areas. This could be explained because of air conditioning systems designing is generally performed both on the basis of the fundamental parameters’ average values, such as temperature, velocity and relative humidity (Ta, va e φa and derived parameters such as operating temperature and mean radiant one (Top eTmr. However, in some specific cases - large open-spaces or in case of radiating surfaces - the descriptors defining indoor comfort conditions, based on average values, do not provide the optimum values required during the air conditioning systems design phase. This is largely due to the variability of real environmental parameters values compared to the average ones taken as input in the calculation. The results obtained in previous scientific papers on the thermal comfort have been the driving element of this work. It offers a simple, original and clever way of thinking about the new domotic systems for air conditioning, based on the “local mean radiant temperature.” This is a very important parameter when one wants to analyze comfort in environments characterized by the presence of radiating surfaces, as will be seen hereinafter. In order to take into account the effects of radiative exchanges in the open-space workplace, where any occupant may find themselves in different temperature and humidity conditions, this paper proposes an action on the domotic climate control, with ducts and vents air distribution placed in different zones. Comparisons were performed between the parameters values representing the punctual thermal comfort, with the Predicted Mean Vote PMV, in an environment marked by radiating surfaces (i

  14. The effect of intrathecal Neostigmine on control of local back pain after lumbar disc surgery

    Directory of Open Access Journals (Sweden)

    "Fakhr Tabatabaei SA

    2002-08-01

    Full Text Available Introduction: As spinal cholinergic receptors exhibit an action against somatic pain, this effect could be potentiated by intrathecal injection of cholinesterase inhibitor-neostigmine. This study was designed to evaluate the role of interathecal neostigmine on local back pain relief after single level lumbar disc surgery. Methods and Materials: In an interventional-expremental study (Imam Khomeini Hospital, Jun. 2000 to sep. 2001, sixty-six patient with unilateral herniated lumbr disc at one lumber space were randomely allocated into two groups including, control (C group and Neostigmine (N group. Both groups underwent fenestration employing same anesthetic techniques. At the end of surgery 2 ml normal saline in groups C and 100 micrograms neostigmine methylsulfate (0.2 ml combined with 1.8 ml normal saline in group N were injected intrathecally postoperative local back pain was measured with 10 cm chart method using Visual Analogue Scale (VAS at 1, 4, 8 and 12 hours. Total dosage of morphine, as an analgesic rescue, used during the first 24 hours following surgery and observed complications were recorded. Results: Mean VAS score postoperatively at 1st and 4th hours were 2.24 (Standard Error Mean, SEM=0.36 and 1.82 (SEM=0.28 in group N and 5.36 (SEM=0.39 and 5.61 (SEM=0.37 in group C respectively. Mean morphine used in the first 24 hours was 0.9 (SEM=0.4 in group N and 4.7 (SEM=0.65 mg in group C. All result were found to be statistically different in the two group (P<0.05. There was no neurologic deficit or CSF leakage in both groups postoperatively. Regarding nausea and vomiting, the difference between two groups C (15 percent and N (24.2 percent were not significant statistically. Conclusion: In this study, we have found that injection of 100 micrograms hyperbaric neostigmine intrathecally is a safe and effective method with minimal complications or side effect for pain relief and curtails postoperative opiate demand.

  15. Analysis of Local Control in Patients Receiving IMRT for Resected Pancreatic Cancers

    Energy Technology Data Exchange (ETDEWEB)

    Yovino, Susannah; Maidment, Bert W. [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States); Herman, Joseph M. [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Pandya, Naimish; Goloubeva, Olga [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States); Wolfgang, Chris; Schulick, Richard; Laheru, Daniel [Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD (United States); Hanna, Nader; Alexander, Richard [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States); Regine, William F., E-mail: wregine@umm.edu [Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD (United States)

    2012-07-01

    Purpose: Intensity-modulated radiotherapy (IMRT) is increasingly incorporated into therapy for pancreatic cancer. A concern regarding this technique is the potential for geographic miss and decreased local control. We analyzed patterns of first failure among patients treated with IMRT for resected pancreatic cancer. Methods and Materials: Seventy-one patients who underwent resection and adjuvant chemoradiation for pancreas cancer are included in this report. IMRT was used for all to a median dose of 50.4 Gy. Concurrent chemotherapy was 5-FU-based in 72% of patients and gemcitabine-based in 28%. Results: At median follow-up of 24 months, 49/71 patients (69%) had failed. The predominant failure pattern was distant metastases in 35/71 patients (49%). The most common site of metastases was the liver. Fourteen patients (19%) developed locoregional failure in the tumor bed alone in 5 patients, regional nodes in 4 patients, and concurrently with metastases in 5 patients. Median overall survival (OS) was 25 months. On univariate analysis, nodal status, margin status, postoperative CA 19-9 level, and weight loss during treatment were predictive for OS. On multivariate analysis, higher postoperative CA19-9 levels predicted for worse OS on a continuous basis (p < 0.01). A trend to worse OS was seen among patients with more weight loss during therapy (p = 0.06). Patients with positive nodes and positive margins also had significantly worse OS (HR for death 2.8, 95% CI 1.1-7.5; HR for death 2.6, 95% CI 1.1-6.2, respectively). Grade 3-4 nausea and vomiting was seen in 8% of patients. Late complication of small bowel obstruction occurred in 4 (6%) patients. Conclusions: This is the first comprehensive report of patterns of failure among patients treated with adjuvant IMRT for pancreas cancer. IMRT was not associated with an increase in local recurrences in our cohort. These data support the use of IMRT in the recently activated EORTC/US Intergroup/RTOG 0848 adjuvant pancreas

  16. Optimizing operation costs of the heating system of a household using model predictive control considering a local PV installation

    DEFF Research Database (Denmark)

    Koch-Ciobotaru, Cosmin; Isleifsson, Fridrik Rafn; Gehrke, Oliver

    2012-01-01

    This paper presents a model predictive controller developed in order to minimize the cost of grid energy consumption and maximize the amount of energy consumed from a local photovoltaic (PV) installation. The usage of as much locally produced renewable energy sources (RES) as possible, diminishes...... the effects of their large penetration in the distribution grid and reduces overloading the grid capacity, which is an increasing problem for the power system. The controller uses 24 hour prediction data for the ambient temperature, the solar irradiance, and for the PV output power. Simulation results...

  17. Using Microsoft Excel to Generate Usage Statistics

    Science.gov (United States)

    Spellman, Rosemary

    2011-01-01

    At the Libraries Service Center, statistics are generated on a monthly, quarterly, and yearly basis by using four Microsoft Excel workbooks. These statistics provide information about what materials are being requested and by whom. They also give details about why certain requests may not have been filled. Utilizing Excel allows for a shallower…

  18. Getting the Best out of Excel

    Science.gov (United States)

    Heys, Chris

    2008-01-01

    Excel, Microsoft's spreadsheet program, offers several tools which have proven useful in solving some optimization problems that arise in operations research. We will look at two such tools, the Excel modules called Solver and Goal Seek--this after deriving an equation, called the "cash accumulation equation", to be used in conjunction with them.

  19. Production management using the EFQM Excellence Model

    Directory of Open Access Journals (Sweden)

    Janja Škedel

    2016-09-01

    Full Text Available Research Question (RQ: Comparison of production management using the EFQM Excellence Model. Purpose: The aim of the research is based on a comparison of production management using the EFQM Excellence Model, to establish identity and difference. The aim is to improve the management of production and by using the model closer to excellence. Method: An identification method of benchmarking. Results: The results show tolerance, which represent an opportunity to improve production management with excellence. Organization: If we take into account the results of the organization, this would be an asset to the organization. Society: Method comparisons can also be used in the wider environment. Originality: The survey is unique and the first of its kind in the manufacturing organization. Limitations/Future Research: With this research we will gain improvements in production management through design excellence.

  20. Development of prepainted steel sheets having excellent formability, stain resistance, and hardness by control of orientation behavior of melamine-formaldehyde resin in the paint film; Kakosei, taiosensei, kodo tokusei ni sugureru precoat koban no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Kanai, H.; Oka, J.; Tsutsumi, M. [Nippon Steel Corp., Tokyo (Japan)

    1994-08-01

    In the present research, the prepainted steel sheet was developed which was coated with melamine-formaldehyde resin (Rm) excelling in stain resistance and hardness. Study was made under various Res/Rm blending conditions by selecting, as a test sample, three types of polyester resin (Res), four types of Rm and two types of catalyst. The superficial structure of coated layer was analyzed by X-ray photoelectron spectroscopy. An Rm-enriched layer could be formed by combining Res of a low hydroxyl value and a strongly acidic catalyst blocked with amine. In such a formation mechanism, catalytic activity directly below the coated surface and self-condensation of Rm were observed during the backing. There exists a positive correlativity between the stain resistance and superficial Rm concentration of blended Res/Rm system. The stain resistance is judged dependent upon the self-condensation. The precoated steel sheet which excels in formability even at a room temperature of 20{degree}C was commercialized and is being sold. As compared with the conventional high-grade products, the present steel sheet is lustrous even through a 24h submergence in 5% NaOH and H2SO4. A stain resistance test in magic ink also gave a good result. 5 refs., 8 figs., 4 tabs.

  1. Randomised controlled trial of local corticosteroid injections for de Quervain's tenosynovitis in general practice

    NARCIS (Netherlands)

    Peters-Veluthamaningal, Cyriac; Winters, Jan C.; Groenier, Klaas H.; Meyboom-deJong, Betty

    2009-01-01

    Background: De Quervain's tenosynovitis is a stenosing tenosynovitis of the first dorsal compartment of the wrist and leads to wrist pain and to impaired function of the wrist and hand. It can be treated by splinting, local corticosteroid injection and operation. In this study effectiveness of local

  2. Method of preliminary localization of the iris in biometric access control systems

    Science.gov (United States)

    Minacova, N.; Petrov, I.

    2015-10-01

    This paper presents a method of preliminary localization of the iris, based on the stable brightness features of the iris in images of the eye. In tests on images of eyes from publicly available databases method showed good accuracy and speed compared to existing methods preliminary localization.

  3. Strong altitudinal control on the response of local glaciers to Holocene climate change in southwest Greenland

    Science.gov (United States)

    Larsen, Nicolaj K.; Strunk, Astrid; Levy, Laura B.; Olsen, Jesper; Bjørk, Anders; Lauridsen, Torben L.; Jeppesen, Erik; Davidson, Thomas A.

    2017-07-01

    Accelerating ice loss during recent years has made the Greenland Ice Sheet one of the largest single contributors to global sea level rise, accounting for 0.5 of the total 3.2 mm yr-1. This loss is predicted to continue and will most likely increase in the future as a consequence of global warming. However, the sensitivity of glaciers and ice caps (GICs) in Greenland to prolonged warm periods is less well constrained and geological records documenting the long-term glacial history are needed to put recent observations into a broader perspective. Here we report the results from three proglacial lakes where fluctuations in local glaciers located at different altitudes in Kobbefjord, southwest Greenland have been recorded. Our results show that the lakes received meltwater from the initial deglaciation of the area ∼9.2 cal. ka BP until ∼8.7-7.9 cal. ka BP when the meltwater input ceased as the glaciers most likely disappeared. Regrowth of glaciers began again at ∼5.5 cal. ka BP at ∼1370 m a.s.l., ∼3.6 cal. ka at ∼1170 m a.s.l., and ∼1.6 cal. ka BP at ∼1000 m a.s.l., clearly reflecting strong altitudinal control of the GIC response to Neoglacial cooling. Our results highlight that GICs in Kobbefjord, southwest Greenland are primarily influenced by changes in summer air temperatures and winter precipitation and that they are facing a rapid decay that most likely will result in their disappearance within the next centuries as a consequence of global warming. If current 21st Century retreat rates continue, the GICs in the study area will be completely gone in ∼30-90 years, with the smallest GICs disappearing first.

  4. Fostering Innovation: How User-Centered Design Can Help Us Get the Local Control Funding Formula Right. Policy and Practice Brief

    Science.gov (United States)

    Knudson, Joel; Ramanathan, Arun; Carter, Allison; O'Day, Jennifer

    2017-01-01

    The Local Control Funding Formula (LCFF) has introduced positive and much-needed change to California's approach to K-12 education funding by allocating resources according to student need and freeing districts to make decisions that address local priorities. For all of LCFF's advantages, however, the Local Control Accountability Plans (LCAPs) in…

  5. Adductor canal block with local infiltrative analgesia compared with local infiltrate analgesia for pain control after total knee arthroplasty: A meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Xing, Qiujuan; Dai, Weiwei; Zhao, Dongfeng; Wu, Ji; Huang, Chunshui; Zhao, Yun

    2017-09-01

    This meta-analysis aimed to evaluate the efficiency and safety of the combined adductor canal block with peri-articular infiltration versus periarticular infiltration alone for pain control after total knee arthroplasty (TKA). PubMed, Medline, Embase, Web of Science, and the Cochrane Library were searched to identify articles comparing the combined adductor canal block with peri-articular infiltration and periarticular infiltration alone for pain control after TKA. Main outcomes were numeric rating scale (NRS) at postoperative day (POD) 0-2 and opioid consumption. Meta-analysis was performed using Stata 11.0 software. Four randomized controlled trial (RCTs) including 297 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between the groups regarding NRS score at POD 0 (weighted mean difference [WMD] = -0.849, 95% confidence interval [CI]: -1.345 to -0.353, P = .001), POD 1 (WMD = -0.960, 95% CI: -1.474 to -0.446, P = .000), and POD 2 (WMD = -0.672, 95% CI: -1.163 to -0.181, P = .007) after TKA. Significant differences were found in terms of opioid consumption at POD 0 (WMD = -3.761, 95% CI: -6.192 to -1.329, P = .002), POD 1 (WMD = -4.795, 95% CI: -8.181 to -1.409, P = .006), and POD 2 (WMD = -2.867, 95% CI: -4.907 to -0.827, P = .006). Combined adductor canal block with peri-articular infiltration could significantly reduce NRS scores and opioid consumption in comparison with periarticular infiltration alone following TKA. Additionally, there is a lower incidence of nausea and vomiting in the combined groups.

  6. People management as indicator of business excellence

    DEFF Research Database (Denmark)

    Haffer, Rafal; Kristensen, Kai

    2010-01-01

    Purpose – This paper aims to show the importance of people management as a key indicator of business excellence based on four research projects, conducted on the samples of Polish (in the years 2004-2005 and 2006-2007) and Danish companies (in 1999 and 2005). Design/methodology/approach – EFQM...... it possible to compare developing Polish and developed Danish companies in their initiatives aiming at business excellence. Findings – The results indicate significant negligence in the management of human resources as one of the initiatives towards business excellence of Polish enterprises before Poland...

  7. Lineær programmering med Excel

    DEFF Research Database (Denmark)

    Lynggaard, Peter

    Publikationen giver en introduktion til faget "Lineær programmering". Formulering og løsning bygger på, at modellerne opstilles og løses i et Excel-regneark. Fremgangsmåden er forklaret trin for trin, således at hæftet kan bruges som selvstudiemateriale. Indholdsfortegnelse Generelt om styring og...... planlægning Lineær programmering Excel solveren Fortolkning af udskrifter Degeneration Excel tips Opgaver med løsninger...

  8. Statistical analysis with Excel for dummies

    CERN Document Server

    Schmuller, Joseph

    2013-01-01

    Take the mystery out of statistical terms and put Excel to work! If you need to create and interpret statistics in business or classroom settings, this easy-to-use guide is just what you need. It shows you how to use Excel's powerful tools for statistical analysis, even if you've never taken a course in statistics. Learn the meaning of terms like mean and median, margin of error, standard deviation, and permutations, and discover how to interpret the statistics of everyday life. You'll learn to use Excel formulas, charts, PivotTables, and other tools to make sense of everything fro

  9. 101 Ready-To-Use Excel Macros

    CERN Document Server

    Alexander, Michael

    2012-01-01

    Save time and be more productive with this helpful guide to Excel macros! While most books about Excel macros offer only minor examples, usually aimed at illustrating a particular topic, this invaluable resource provides you with the tools needed to efficiently and effectively program Excel macros immediately. Step-by-step instructions show you how to create VBA macros and explain how to customize your applications to look and work exactly as you want them to. By the end of the book, you will understand how each featured macro works, be able to reuse the macros included in the book and online,

  10. Microsoft Office Excel 2003 Inside Out

    CERN Document Server

    Stinson, Craig

    2003-01-01

    Hey, you know your way around a spreadsheet-so now dig into Excel 2003 and really put your data to work! This supremely organized reference packs hundreds of timesaving solutions, troubleshooting tips, and handy workarounds in concise, fast-answer format. It's all muscle and no fluff. Discover the best and fastest ways to perform everyday tasks, and challenge yourself to new levels of Excel mastery! Build on what you already know about Excel and quickly dive into what's newLearn how the experts design more powerful spreadsheetsSharpen your core to advanced document editing and formatting skil

  11. Advanced Excel for scientific data analysis

    CERN Document Server

    De Levie, Robert

    2004-01-01

    Excel is by far the most widely distributed data analysis software but few users are aware of its full powers. Advanced Excel For Scientific Data Analysis takes off from where most books dealing with scientific applications of Excel end. It focuses on three areas-least squares, Fourier transformation, and digital simulation-and illustrates these with extensive examples, often taken from the literature. It also includes and describes a number of sample macros and functions to facilitate common data analysis tasks. These macros and functions are provided in uncompiled, computer-readable, easily

  12. What Makes an Excellent Lecturer? Academics' Perspectives on the Discourse of "Teaching Excellence" in Higher Education

    Science.gov (United States)

    Wood, Margaret; Su, Feng

    2017-01-01

    In the context of the Teaching Excellence Framework (TEF), we examine academics' perspectives on the discourse of "teaching excellence" based on an empirical study with 16 participants from five post-1992 universities. The article reports the findings on academics' views of the term and concept of "teaching excellence",…

  13. Excellence in the Knowledge-Based Economy: From Scientific to Research Excellence

    Science.gov (United States)

    Sørensen, Mads P.; Bloch, Carter; Young, Mitchell

    2016-01-01

    In 2013, the European Union (EU) unveiled its new "Composite Indicator for Scientific and Technological Research Excellence." This is not an isolated occurrence; policy-based interest in excellence is growing all over the world. The heightened focus on excellence and, in particular, attempts to define it through quantitative indicators…

  14. Dynamics of Spontaneous Emission Controlled by Local Density of States in Photonic Crystals

    DEFF Research Database (Denmark)

    Lodahl, Peter; Nikolaev, Ivan S.; van Driel, A. Floris

    2006-01-01

    We have measured time-resolved spontaneous emission from quantum dots in 3D photonic crystals. Due to the spatially dependent local density of states, the distribution of decay rates varies strongly with the photonic crystal lattice parameter.......We have measured time-resolved spontaneous emission from quantum dots in 3D photonic crystals. Due to the spatially dependent local density of states, the distribution of decay rates varies strongly with the photonic crystal lattice parameter....

  15. Persistence, Localization, and External Control of Transgene Expression After Single Injection of Adeno-Associated Virus into Injured Joints

    Science.gov (United States)

    Lee, Hannah H.; O'Malley, Michael J.; Friel, Nicole A.; Payne, Karin A.; Qiao, Chunping; Xiao, Xiao

    2013-01-01

    Abstract A single intra-articular injection of adeno-associated virus (AAV) results in stable and controllable transgene expression in normal rat knees. Because undamaged joints are unlikely to require treatment, the study of AAV delivery in joint injury models is crucial to potential therapeutic applications. This study tests the hypotheses that persistent and controllable AAV-transgene expression are (1) highly localized to the cartilage when AAV is injected postinjury and (2) localized to the intra-articular soft tissues when AAV is injected preinjury. Two AAV injection time points, postinjury and preinjury, were investigated in osteochondral defect and anterior cruciate ligament transection models of joint injury. Rats injected with AAV tetracycline response element (TRE)–luciferase received oral doxycycline for 7 days. Luciferase expression was evaluated longitudinally for 6 months. Transgene expression was persistent and controllable with oral doxycycline for 6 months in all groups. However, the location of transgene expression was different: postinjury AAV-injected knees had luciferase expression highly localized to the cartilage, while preinjury AAV-injected knees had more widespread signal from intra-articular soft tissues. The differential transgene localization between preinjury and postinjury injection can be used to optimize treatment strategies. Highly localized postinjury injection appears advantageous for treatments targeting repair cells. The more generalized and controllable reservoir of transgene expression following AAV injection before anterior cruciate ligament transection (ACLT) suggests an intriguing concept for prophylactic delivery of joint protective factors to individuals at high risk for early osteoarthritis (OA). Successful external control of intra-articular transgene expression provides an added margin of safety for these potential clinical applications. PMID:23496155

  16. Five-year Local Control in a Phase II Study of Hypofractionated Intensity Modulated Radiation Therapy With an Incorporated Boost for Early Stage Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Freedman, Gary M., E-mail: Gary.Freedman@uphs.upenn.edu [Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Anderson, Penny R. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Bleicher, Richard J. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Litwin, Samuel; Li Tianyu [Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Swaby, Ramona F. [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Ma, Chang-Ming Charlie; Li Jinsheng [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Sigurdson, Elin R. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States); Watkins-Bruner, Deborah [School of Nursing, Emory University, Atlanta, Georgia (United States); Morrow, Monica [Department of Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Goldstein, Lori J. [Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (United States)

    2012-11-15

    Purpose: Conventional radiation fractionation of 1.8-2 Gy per day for early stage breast cancer requires daily treatment for 6-7 weeks. We report the 5-year results of a phase II study of intensity modulated radiation therapy (IMRT), hypofractionation, and incorporated boost that shortened treatment time to 4 weeks. Methods and Materials: The study design was phase II with a planned accrual of 75 patients. Eligibility included patients aged {>=}18 years, Tis-T2, stage 0-II, and breast conservation. Photon IMRT and an incorporated boost was used, and the whole breast received 2.25 Gy per fraction for a total of 45 Gy, and the tumor bed received 2.8 Gy per fraction for a total of 56 Gy in 20 treatments over 4 weeks. Patients were followed every 6 months for 5 years. Results: Seventy-five patients were treated from December 2003 to November 2005. The median follow-up was 69 months. Median age was 52 years (range, 31-81). Median tumor size was 1.4 cm (range, 0.1-3.5). Eighty percent of tumors were node negative; 93% of patients had negative margins, and 7% of patients had close (>0 and <2 mm) margins; 76% of cancers were invasive ductal type: 15% were ductal carcinoma in situ, 5% were lobular, and 4% were other histology types. Twenty-nine percent of patients 29% had grade 3 carcinoma, and 20% of patients had extensive in situ carcinoma; 11% of patients received chemotherapy, 36% received endocrine therapy, 33% received both, and 20% received neither. There were 3 instances of local recurrence for a 5-year actuarial rate of 2.7%. Conclusions: This 4-week course of hypofractionated radiation with incorporated boost was associated with excellent local control, comparable to historical results of 6-7 weeks of conventional whole-breast fractionation with sequential boost.

  17. Supporting breastfeeding In Local Communities (SILC): protocol for a cluster randomised controlled trial.

    Science.gov (United States)

    McLachlan, Helen L; Forster, Della A; Amir, Lisa H; Small, Rhonda; Cullinane, Meabh; Watson, Lyndsey F; Shafiei, Touran

    2014-10-03

    Breastfeeding is associated with significant positive health outcomes for mothers and infants. However, despite recommendations from the World Health Organization, exclusive breastfeeding for six months is uncommon. Increased breastfeeding support early in the postpartum period may be effective in improving breastfeeding maintenance. This trial will evaluate two community-based interventions to increase breastfeeding duration in Local Government Areas (LGAs) in Victoria, Australia. A three-arm cluster randomised controlled trial design will be used. Victorian LGAs with a lower than average rate of any breastfeeding at discharge from hospital and more than 450 births per year that agree to participate will be randomly allocated to one of three trial arms: 1) standard care; 2) home-based breastfeeding support; or 3) home-based breastfeeding support plus access to a community-based breastfeeding drop-in centre. The services provided in LGAs allocated to 'standard care' are those routinely available to postpartum women. LGAs allocated to the home-based visiting intervention will provide home-visits to women who are identified as at risk of breastfeeding cessation in the early postnatal period. These visits will be provided by Maternal and Child Health Nurses who have received training to provide the intervention (SILC-MCHNs). In areas allocated to receive the second intervention, in addition to home-based breastfeeding support, community breastfeeding drop-in centres will be made available, staffed by a SILC-MCHN. The interventions will run in LGAs for a nine to twelve month period depending on birth numbers. The primary outcome is the proportion of infants receiving any breast milk at four months of age. Breastfeeding outcomes will be obtained from routinely collected Maternal and Child Health centre data and from a new data item collecting infant feeding 'in the last 24 hours'. Information will also be obtained directly from women via a postal survey. A comprehensive

  18. Introduction to statistics using Microsoft Excel

    CERN Document Server

    Remenyi, Dan; English, Joseph

    2011-01-01

    This book explains the statistical concepts and then uses Microsoft Excel functions to illustrate how to get results using the appropriate techniques which will help researchers directly with their research.

  19. Predictors of excellent response to lithium

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hellmund, Gunnar; Andersen, Per Kragh

    2011-01-01

    The aim of this study was to identify sociodemographic and clinical predictors of excellent response, that is, 'cure' of future affective episodes, to lithium in monotherapy. We used nationwide registers to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings...... who were prescribed lithium from 1995 to 2006 in Denmark (N=3762). Excellent lithium responders were defined as patients who after a stabilization lithium start-up period of 6 months, continued lithium in monotherapy without getting hospitalized. The rate of excellent response to lithium...... with somatic comorbidity had increased rates of non-response to lithium compared with patients without somatic comorbidity (HR=1.23, 95% CI: 1.00-1.52).It is concluded that the prevalence of excellent response to lithium monotherapy is low and such patients are characterized by few earlier psychiatric...

  20. Faculty Evaluation Stimulates Expectations of Excellence.

    Science.gov (United States)

    Andrews, Hans A.; Marzano, William A.

    1984-01-01

    Considers important elements of comprehensive faculty evaluation systems (e.g., provision of formative feedback for instructors performing unsatisfactorily and of incentives for excellence). Details the development and results of the evaluation system at Illinois Valley Community College. (LAL)

  1. Editorial: South African Guidelines Excellence (SAGE): Efficient ...

    African Journals Online (AJOL)

    Editorial: South African Guidelines Excellence (SAGE): Efficient, effective and unbiased clinical practice guideline teams. Karen Grimmer, Janine Margarita Dizon, Quinette Louw, Tamara Kredo, Taryn Young, Shingai Machingaidze ...

  2. Contribution of Lean Management to Excellence

    Directory of Open Access Journals (Sweden)

    López-Fresno Palmira

    2014-11-01

    Full Text Available To continuously and systematically improve efficiency and efficacy of processes, organizations need the implication of all employees in continuous improvement and innovation through suitable Quality Management Programs (QMPs. Effectiveness of these programs is directly linked to the requirement employees understand the methodologies and tools used for QM and the benefits that will derivate from their implementation, individually and collectively, so they can commit and implicate. Lean Management is a friendly methodology to continuously and systematically achieve process improvement, so helping the organization seeking operational excellence that contributes to overall excellence. This paper identifies Critical Success Factors (CSFs for an effective implementation of QMPs, suggests Lean Management as an easy-to-understand, powerful and friendly methodology for operational excellence and overall excellence, and presents a case experience of implementation of Lean Management in a health care organization that applies the EFQM model, and the lessons learnt.

  3. Investigation on a new local control technology with near-infrared spectroscopy for laser induced interstitial thermotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Hua Guoran; Zhang Hua; Qian Aiping; Qian Zhiyu, E-mail: nuaazhh@126.com, E-mail: ntuzhh@ntu.edu.cn [School of Mechanical Engineering, Nantong University, Nantong, Jiangsu 226019 (China)

    2011-02-01

    In order to control the treatment of laser-induced interstitial thermotherapy, a new local control technique is put forward, which use a functional near infrared spectroscopy (fNIRS) system. The temperature of biological tissue is regarded as the most important indicator for treatment of LITT. So, based on the experiments of LITT being performed on a liver cancer, the temperature and reducing scattering coefficient have been obtained in real time, respectively, with probe-type thermometer and fNIRS system. The results of the two factors have the same trend with different power of laser. It is confirmed that the fNIRS can be a useful local control technology for LITT.

  4. The Business Excellence Model for CSR Implementation?

    DEFF Research Database (Denmark)

    Neergaard, Peter; Gjerdrum Pedersen, Esben Rahbek

    2012-01-01

    Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating...... European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus....

  5. Idea of Quality Versus Idea of Excellence

    Directory of Open Access Journals (Sweden)

    Marko Kiauta

    2012-12-01

    Full Text Available This study investigates professionals on the field of quality, are responsible to give to customer honest clarification of fundamental ideas. Quality movement is losing credibility with suggesting that the idea of quality is replacing with the idea of excellence. Findings are based on more than 25 years of practice in professional promotion of quality: in consulting on private and public sector, from 1990 lead auditor at SIQ (Slovenian Institute of Quality, from 1998 lead assessor – commission for Slovenian Excellence Quality Award. Theory is developed based on: Noriaki Kano theory of Attractive quality, Tito Conti ideas on TQM and applications problems of Excellence model, Practical case of General Hospital Novo Mesto (in 1998 first attempt of using EM, than forced to build QMS based on ISO 9001 and then returned to practice EM. Findings: We really need to amplify and to understand the concept of quality in a much wider way. To treat excellence related activities separated from all others quality management activities is not god solution. The name of EFQM Excellence Model should be replaced with Quality Management Model. Research limitations/implications: This paper present findings mainly based on practice in Slovenia and especially in public sector where practicing of CAF is not giving expected benefits. Practical implications: The three styles of quality management (improvements to reach demands, improvements to reach expectations, improvements to react on new conditions and needs should be connected with personal development. Theory is developed based on: Noriaki Kano theory of Attractive quality, Tito Conti ideas on TQM and applications problems of Excellence model. We need integration moments. Integration is other word for creativity and health. It leads to integrity. Excellence is only one of three states of quality. If we ask: How? The answer is bad, good or excellent. All three are possible states of the same parameter.

  6. Acupuncture at local and distal points for chronic shoulder pain: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Fu, Qing-Nan; Shi, Guang-Xia; Li, Qian-Qian; He, Tian; Liu, Bao-Zhen; Sun, San-Feng; Wang, Jun; Tan, Cheng; Yang, Bo-Feng; Liu, Cun-Zhi

    2014-04-17

    Chronic shoulder pain (CSP) is the third most common type of musculoskeletal pain. It has a major impact on health-related quality of life. In Chinese medicine, CSP is considered one of the conditions most amenable to treatment with acupuncture. The purpose of this study is to evaluate the efficacy of local acupoints in combination with distal acupoints in pain relief and shoulder function improvement in CSP patients. This is a multicenter, single blind, factorial randomized controlled clinical trial. A total of 164 participants will be randomly allocated to four different groups: Group A will receive acupuncture at local acupoints in combination with distal acupoint. Group B will receive acupuncture at local acupoints in combination with distal non-acupoint. Group C will receive acupuncture at local non-acupoints in combination with distal acupoint. Group D will receive acupuncture at local non-acupoints in combination with distal non-acupoint. Each group will receive 12 treatments of acupuncture one to three times per week for six weeks in total. The primary outcome is shoulder pain intensity, which is graded using a 100 -mm Visual Analogue Scale. The assessment is at baseline (before treatment initiation), 6 weeks after the first acupuncture, 10 weeks after the first acupuncture and 18 weeks after the first acupuncture. This trial will be helpful in identifying whether acupuncture at local acupoints in combination with distal acupoints may be more effective than needling points separately. International Standard Randomized Controlled Trial Number Register: ISRCTN61861069 (http://www.controlled-trials.com).

  7. Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research.

    Science.gov (United States)

    Tanavalee, Chotetawan; Luksanapruksa, Panya; Singhatanadgige, Weerasak

    2016-06-01

    Microsoft Excel (MS Excel) is a commonly used program for data collection and statistical analysis in biomedical research. However, this program has many limitations, including fewer functions that can be used for analysis and a limited number of total cells compared with dedicated statistical programs. MS Excel cannot complete analyses with blank cells, and cells must be selected manually for analysis. In addition, it requires multiple steps of data transformation and formulas to plot survival analysis graphs, among others. The Megastat add-on program, which will be supported by MS Excel 2016 soon, would eliminate some limitations of using statistic formulas within MS Excel.

  8. Deciphering the Neuronal Circuitry Controlling Local Blood Flow in the Cerebral Cortex with Optogenetics in PV::Cre Transgenic Mice

    Science.gov (United States)

    Urban, Alan; Rancillac, Armelle; Martinez, Lucie; Rossier, Jean

    2012-01-01

    Although it is know since more than a century that neuronal activity is coupled to blood supply regulation, the underlying pathways remains to be identified. In the brain, neuronal activation triggers a local increase of cerebral blood flow (CBF) that is controlled by the neurogliovascular unit composed of terminals of neurons, astrocytes, and blood vessel muscles. It is generally accepted that the regulation of the neurogliovascular unit is adjusted to local metabolic demand by local circuits. Today experimental data led us to realize that the regulatory mechanisms are more complex and that a neuronal system within the brain is devoted to the control of local brain-blood flow. Recent optogenetic experiments combined with functional magnetic resonance imaging have revealed that light stimulation of neurons expressing the calcium binding protein parvalbumin (PV) is associated with positive blood oxygen level-dependent (BOLD) signal in the corresponding barrel field but also with negative BOLD in the surrounding deeper area. Here, we demonstrate that in acute brain slices, channelrhodopsin-2 (ChR2) based photostimulation of PV containing neurons gives rise to an effective contraction of penetrating arterioles. These results support the neurogenic hypothesis of a complex distributed nervous system controlling the CBF. PMID:22715327

  9. 101 ready-to-use Excel formulas

    CERN Document Server

    Alexander, Michael

    2014-01-01

    Mr. Spreadsheet has done it again with 101 easy-to-apply Excel formulas 101 Ready-to-Use Excel Formulas is filled with the most commonly-used, real-world Excel formulas that can be repurposed and put into action, saving you time and increasing your productivity. Each segment of this book outlines a common business or analysis problem that needs to be solved and provides the actual Excel formulas to solve the problem-along with detailed explanation of how the formulas work. Written in a user-friendly style that relies on a tips and tricks approach, the book details how to perform everyday Excel tasks with confidence. 101 Ready-to-Use Excel Formulas is sure to become your well-thumbed reference to solve your workplace problems. The recipes in the book are structured to first present the problem, then provide the formula solution, and finally show how it works so that it can be customized to fit your needs. The companion website to the book allows readers to easily test the formulas and provides visual confirmat...

  10. A Question of Control: Licensing Local Ritual Specialists in Jiangnan, 1850-1950

    OpenAIRE

    Goossaert, Vincent

    2013-01-01

    This paper considers various types of vernacular specialists, such as at-home Daoist masters (huoju daoshi 火居道士), lay Buddhist monks, Confucian priests 禮生, diviners (yinyang sheng 陰陽生), actors and musicians, storytellers, and spirit-mediums, with the primary focus on the first of these types. My primary geographical focus is on Jiangnan as a local system, but I also draw examples and comparisons from other areas. I will first consider late Qing practices as seen in newspaper reports, local ar...

  11. Local Scrape-Off Layer Control Using Biased electrodes in NSTX

    Energy Technology Data Exchange (ETDEWEB)

    Zweben, S J; Maqueda, R J; Roquemore, A L; Bush, C E; Kaita, R; Marsala, R J; Raitses, Y; Cohen, R H; Ryutov, D D

    2009-06-23

    An experiment was designed to test the theory that biased electrodes can affect the local scrape-off layer (SOL) width by creating a strong radial ExB drift [Cohen, R.H. and Ryutov, D.D, Nucl. Fusion 37, 621 (1997)]. These electrodes were located near the outer midplane in the SOL of the National Spherical Torus Experiment (NSTX). The electrodes were biased at up to {+-} 100 Volts, and the radial profile of the plasma between them was measured by an array of Langmuir probes. The biasing caused large changes in the local SOL profiles at least qualitatively consistent with this theory.

  12. Local scrape-off layer control using biased electrodes in NSTX

    Energy Technology Data Exchange (ETDEWEB)

    Zweben, S. J. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Maqueda, R. J. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Roquemore, A. L. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Bush, C. E. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Kaita, R. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Marsala, R. J. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Raitses, Y. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Cohen, R. H. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Ryutov, D. D. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States)

    2009-04-01

    An experiment was designed to test the theory that biased electrodes can affect the local scrape-off layer (SOL) width by creating a strong radial ExB drift [Cohen, R.H. and Ryutov, D.D, Nucl. Fusion 37, 621 (1997)]. These electrodes were located near the outer midplane in the SOL of the National Spherical Torus Experiment (NSTX). The electrodes were biased at up to 100 Volts, and the radial profile of the plasma between them was measured by an array of Langmuir probes. The biasing caused large changes in the local SOL profiles at least qualitatively consistent with this theory.

  13. Initial results of local grid control using wind farms with grid support

    DEFF Research Database (Denmark)

    Sørensen, Poul Ejnar; Hansen, Anca Daniela; Iov, F.

    2005-01-01

    This report describes initial results with simulation of power system control using wind farms with grid support.......This report describes initial results with simulation of power system control using wind farms with grid support....

  14. Compressing Sensing Based Source Localization for Controlled Acoustic Signals Using Distributed Microphone Arrays

    Directory of Open Access Journals (Sweden)

    Wei Ke

    2017-01-01

    Full Text Available In order to enhance the accuracy of sound source localization in noisy and reverberant environments, this paper proposes an adaptive sound source localization method based on distributed microphone arrays. Since sound sources lie at a few points in the discrete spatial domain, our method can exploit this inherent sparsity to convert the localization problem into a sparse recovery problem based on the compressive sensing (CS theory. In this method, a two-step discrete cosine transform- (DCT- based feature extraction approach is utilized to cover both short-time and long-time properties of acoustic signals and reduce the dimensions of the sparse model. In addition, an online dictionary learning (DL method is used to adjust the dictionary for matching the changes of audio signals, and then the sparse solution could better represent location estimations. Moreover, we propose an improved block-sparse reconstruction algorithm using approximate l0 norm minimization to enhance reconstruction performance for sparse signals in low signal-noise ratio (SNR conditions. The effectiveness of the proposed scheme is demonstrated by simulation results and experimental results where substantial improvement for localization performance can be obtained in the noisy and reverberant conditions.

  15. Supporting breastfeeding In Local Communities (SILC): protocol for a cluster randomised controlled trial

    OpenAIRE

    McLachlan, Helen L; Forster, Della A; Amir, Lisa H; Small, Rhonda; Cullinane, Meabh; Watson, Lyndsey F; Shafiei, Touran

    2014-01-01

    Background Breastfeeding is associated with significant positive health outcomes for mothers and infants. However, despite recommendations from the World Health Organization, exclusive breastfeeding for six months is uncommon. Increased breastfeeding support early in the postpartum period may be effective in improving breastfeeding maintenance. This trial will evaluate two community-based interventions to increase breastfeeding duration in Local Government Areas (LGAs) in Victoria, Australia....

  16. Village Alcohol Control and the Local Option Law. A Report to the Alaska State Legislature.

    Science.gov (United States)

    Lonner, Thomas D.; Duff, J. Kenneth

    This is a report on Alaska's "local option law" which allows villages to choose one of the following four options on alcohol availability in their communities: (1) the sale of alcoholic beverages is prohibited unless sold under a community liquor license; (2) the sale of alcoholic beverages is limited to one of several types of retail…

  17. Liminal Surveillance. An ethnographic control room study during a local event

    NARCIS (Netherlands)

    Boersma, F.K.

    2013-01-01

    This article is about the targeted, temporarily intensified use of an already existing, permanently installed surveillance system for the safety and security management during a local event at the campus of the University of Illinois, USA. In particular it is the CCTV system that is analyzed after

  18. On the Impact of Localization and Density Control Algorithms in Target Tracking Applications forWireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Joel J. P. C. Rodrigues

    2012-05-01

    Full Text Available Target tracking is an important application of wireless sensor networks. The networks’ ability to locate and track an object is directed linked to the nodes’ ability to locate themselves. Consequently, localization systems are essential for target tracking applications. In addition, sensor networks are often deployed in remote or hostile environments. Therefore, density control algorithms are used to increase network lifetime while maintaining its sensing capabilities. In this work, we analyze the impact of localization algorithms (RPE and DPE and density control algorithms (GAF, A3 and OGDC on target tracking applications. We adapt the density control algorithms to address the k-coverage problem. In addition, we analyze the impact of network density, residual integration with density control, and k-coverage on both target tracking accuracy and network lifetime. Our results show that DPE is a better choice for target tracking applications than RPE. Moreover, among the evaluated density control algorithms, OGDC is the best option among the three. Although the choice of the density control algorithm has little impact on the tracking precision, OGDC outperforms GAF and A3 in terms of tracking time.

  19. Long-Term Glycemic Control in Adult Patients Undergoing Remote vs. Local Total Pancreatectomy With Islet Autotransplantation.

    Science.gov (United States)

    Kesseli, Samuel J; Wagar, Matthew; Jung, Min K; Smith, Kerrington D; Lin, Yu Kuei; Walsh, R Matthew; Hatipoglu, Betul; Freeman, Martin L; Pruett, Timothy L; Beilman, Gregory J; Sutherland, David E R; Dunn, Ty B; Axelrod, David A; Chaidarun, Sushela S; Stevens, Tyler K; Bellin, Melena; Gardner, Timothy B

    2017-04-01

    Total pancreatectomy with islet autotransplantation (TPIAT) is increasingly performed with remote islet cell processing and preparation, i.e., with islet cell isolation performed remotely from the primary surgical site at an appropriately equipped islet isolation facility. We aimed to determine whether TPIAT using remote islet isolation results in comparable long-term glycemic outcomes compared with TPIAT performed with standard local isolation. We performed a retrospective cohort study of adult patients who underwent TPIAT at three tertiary care centers from 2010 to 2013. Two centers performed remote isolation and one performed local isolation. Explanted pancreata in the remote cohort were transported ∼130 miles to and from islet isolation facilities. The primary outcome was insulin independence 1 year following transplant. Baseline characteristics were similar between groups except the remote cohort had higher preoperative hemoglobin A1c (HbA1c; 5.43 vs. 5.25, P=0.02) and there were more females in the local cohort (58% vs. 76%, P=0.049). At 1 year, 27% of remote and 32% of local patients were insulin independent (P=0.48). Remote patients experienced a greater drop in fasting c-peptide (-1.66 vs. -0.64, P=0.006) and a greater rise in HbA1c (1.65 vs. 0.99, P=0.014) at 1-year follow-up. A preoperative c-peptide >2.7 (odds ratio (OR) 4.4, 95% confidence interval (CI) 1.6-14.3) and >3,000 islet equivalents/kg (OR 11.0, 95% CI 3.2-37.3) were associated with one-year insulin independence in the local group. At 1 year after TPIAT, patients undergoing remote surgery have equivalent rates of long-term insulin independence compared with patients undergoing TPIAT locally, but metabolic control is superior with local isolation.

  20. Creating cultures of excellence: Strategies and outcomes

    Directory of Open Access Journals (Sweden)

    Michael Mintrom

    2014-12-01

    Full Text Available Research findings on effective support for learning, the development of expertise, and the psychology of success suggest that the pursuit of excellence is teachable. Within the emerging field of research and practice termed “the scholarship of teaching and learning,” considerable effort has been made to document the practices of teachers who, by various measures, have been deemed excellent. In contrast, no effort has been made to codify how students can be trained to self-consciously build behaviors that generate excellent outcomes. This article reports on a multi-year effort to create cultures of excellence among cohorts of graduate students. A statistical analysis of subsequent student performance on a significant, related task indicates that explicitly promoting a culture of excellence among course participants can have a positive and sustained impact on their individual practices. Comments from subsequent student reflections further support this claim. The teaching strategies reported here could be refined, replicated, and reinvented to good effect across higher education. They are also of special relevance to those delivering professional development training to early- and mid-career professionals.

  1. Well controlled multiple resistive switching states in the Al local doped HfO2 resistive random access memory device

    Science.gov (United States)

    Chen, Y. S.; Chen, B.; Gao, B.; Liu, L. F.; Liu, X. Y.; Kang, J. F.

    2013-04-01

    The resistive switching behaviors in the sandwiched Ti/HfO2/Pt devices with different doping condition were systematically investigated. We show that, comparing with the undoped and the Al layer doped HfO2 devices, significant improvement of switching characteristics is achieved in the Al local doped HfO2 device, including uniformity, reliability, and operation current. As a result, well controlled multiple switching states are obtained in the local doping device by modulating the set current compliance or the maximal reset voltage, respectively. Our results suggest that the switching characteristics of HfO2 device are very closely related to the inducement and controlling of conductive filaments' growth in the dielectric layer, which can be considered in the optimization of resistive random access memory device design.

  2. Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells.

    Science.gov (United States)

    Niopek, Dominik; Benzinger, Dirk; Roensch, Julia; Draebing, Thomas; Wehler, Pierre; Eils, Roland; Di Ventura, Barbara

    2014-07-14

    The function of many eukaryotic proteins is regulated by highly dynamic changes in their nucleocytoplasmic distribution. The ability to precisely and reversibly control nuclear translocation would, therefore, allow dissecting and engineering cellular networks. Here we develop a genetically encoded, light-inducible nuclear localization signal (LINuS) based on the LOV2 domain of Avena sativa phototropin 1. LINuS is a small, versatile tag, customizable for different proteins and cell types. LINuS-mediated nuclear import is fast and reversible, and can be tuned at different levels, for instance, by introducing mutations that alter AsLOV2 domain photo-caging properties or by selecting nuclear localization signals (NLSs) of various strengths. We demonstrate the utility of LINuS in mammalian cells by controlling gene expression and entry into mitosis with blue light.

  3. A Multicentered, Randomized, Controlled Trial Comparing Radioguided Seed Localization to Standard Wire Localization for Nonpalpable, Invasive and in situ Breast Carcinomas

    National Research Council Canada - National Science Library

    Lovrics, Peter J; Goldsmith, Charlie H; Hodgson, Nicole; McCready, David; Gohla, Gabriela; Boylan, Colm; Cornacchi, Sylvie; Reedijk, Michael

    2011-01-01

    ...) undergoing localization and breast conserving surgery were enrolled. Outcomes measured include positive margin and reoperation rates, specimen weight, operative and localization times, and surgeon and radiologist ranking of procedural...

  4. Local Control for Intermediate-Risk Rhabdomyosarcoma: Results From D9803 According to Histology, Group, Site, and Size: A Report From the Children's Oncology Group

    Energy Technology Data Exchange (ETDEWEB)

    Wolden, Suzanne L., E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Lyden, Elizabeth R. [Department of Preventive and Societal Medicine, Nebraska Medical Center, Omaha, Nebraska (United States); Arndt, Carola A. [Department of Pediatric and Adolescent Medicine, Mayo Clinic and Foundation, Rochester, Minnesota (United States); Hawkins, Douglas S. [Division of Hematology/Oncology, Seattle Children' s Hospital, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington (United States); Anderson, James R. [Frontier Science and Technology Research Foundation, Madison, Wisconsin (United States); Rodeberg, David A. [Department of Surgery, East Carolina University, Greenville, North Carolina (United States); Morris, Carol D. [Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States)

    2015-12-01

    Purpose: To determine local control according to clinical variables for patients with intermediate-risk rhabdomyosarcoma (RMS) treated on Children's Oncology Group protocol D9803. Patients and Methods: Of 702 patients enrolled, we analyzed 423 patients with central pathology–confirmed group III embryonal (n=280) or alveolar (group III, n=102; group I-II, n=41) RMS. Median age was 5 years. Patients received 42 weeks of VAC (vincristine, dactinomycin, cyclophosphamide) or VAC alternating with VTC (T = topotecan). Local therapy with 50.4 Gy radiation therapy with or without delayed primary excision began at week 12 for group III patients. Patients with group I/II alveolar RMS received 36-41.4 Gy. Local failure (LF) was defined as local progression as a first event with or without concurrent regional or distant failure. Results: At a median follow-up of 6.6 years, patients with clinical group I/II alveolar RMS had a 5-year event-free survival rate of 69% and LF of 10%. Among patients with group III RMS, 5-year event-free survival and LF rates were 70% and 19%, respectively. Local failure rates did not differ by histology, nodal status, or primary site, though there was a trend for increased LF for retroperitoneal (RP) tumors (P=.12). Tumors ≥5 cm were more likely to fail locally than tumors <5 cm (25% vs 10%, P=.0004). Almost all (98%) RP tumors were ≥5 cm, with no difference in LF by site when the analysis was restricted to tumors ≥5 cm (P=.86). Conclusion: Local control was excellent for clinical group I/II alveolar RMS. Local failure constituted 63% of initial events in clinical group III patients and did not vary by histology or nodal status. The trend for higher LF in RP tumors was related to tumor size. There has been no clear change in local control over RMS studies, including IRS-III and IRS-IV. Novel approaches are warranted for larger tumors (≥5 cm).

  5. Excellence in the knowledge-based economy: from scientific to research excellence

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Bloch, Carter Walter; Young, Mitchell

    2016-01-01

    to define it through quantitative indicators can have important implications for research policy and for the conduct of research itself. This paper examines how the EU's understanding of excellence has evolved in recent years, from the presentation of the Lisbon strategy in 2000 to the current Europe 2020......In 2013, the European Union (EU) unveiled its new ‘Composite Indicator for Scientific and Technological Research Excellence’. This is not an isolated occurrence; policy-based interest in excellence is growing all over the world. The heightened focus on excellence and, in particular, attempts...... strategy. We find a distinct shift in the understanding of excellence and how success in the knowledge-based economy should be achieved: in the early period, excellence is a fuzzy concept, intrinsically embedded in research and researchers and revealed by peer review. In the later period, excellence...

  6. Ear acupuncture or local anaesthetics as pain relief during postpartum surgical repair: a randomised controlled trial

    DEFF Research Database (Denmark)

    Kindberg, S; Klünder, L; Strøm, J

    2009-01-01

    -hour hands-on training in the use of ear acupuncture. All midwives (n= 36) in the department had previous experience in using acupuncture for obstetric pain relief. Pain and wound healing were evaluated using validated scores. Data collection was performed by research assistants blinded towards...... treatment allocation. Randomisation was computer assisted. A total of 207 women were randomised to receive ear acupuncture (105) and local anaesthetics (102), respectively. Main outcome measures The primary outcome was pain during surgical repair. Secondary outcomes were wound healing at 24-48 hours and 14...... days postpartum, participant satisfaction, revision of wound or dyspareunia reported 6 months postpartum. Results Pain during surgical repair was more frequently reported by participants allocated to ear acupuncture compared with participants receiving local anaesthetics (89 versus 54%, P

  7. Auto Draw from Excel Input Files

    Science.gov (United States)

    Strauss, Karl F.; Goullioud, Renaud; Cox, Brian; Grimes, James M.

    2011-01-01

    The design process often involves the use of Excel files during project development. To facilitate communications of the information in the Excel files, drawings are often generated. During the design process, the Excel files are updated often to reflect new input. The problem is that the drawings often lag the updates, often leading to confusion of the current state of the design. The use of this program allows visualization of complex data in a format that is more easily understandable than pages of numbers. Because the graphical output can be updated automatically, the manual labor of diagram drawing can be eliminated. The more frequent update of system diagrams can reduce confusion and reduce errors and is likely to uncover symmetric problems earlier in the design cycle, thus reducing rework and redesign.

  8. Local Antibiotic Delivery Using Tailorable Chitosan Sponges: The Future of Infection Control?

    Science.gov (United States)

    2010-09-01

    sulfate pellets may develop sterile draining sinuses .3 Although they usually heal on pellet resorption, they can mimic an infected draining sinus as a...antibiotic therapy for severe open fractures: a review of 1085 consecutive cases. J Bone Joint Surg Br. 1995;77:93–97. 3. McKee MD, Wild LM, Schemitsch...Preliminary in vitro evaluation of an adjunctive therapy for extremity wound infection reduction: rapidly resorbing local antibiotic delivery. J Orthop Res

  9. Climate drives fire synchrony but local factors control fire regime change in northern Mexico

    Science.gov (United States)

    Larissa L. Yocom Kent; Peter Z. Fulé; Peter M. Brown; Julián Cerano-Paredes; Eladio Cornejo-Oviedo; Citlali Cortés Montaño; Stacy A. Drury; Donald A. Falk; Jed Meunier; Helen M. Poulos; Carl N. Skinner; Scott L. Stephens; José Villanueva-Díaz

    2017-01-01

    The occurrence of wildfire is influenced by a suite of factors ranging from “top-down” influences (e.g., climate) to “bottom-up” localized influences (e.g., ignitions, fuels, and land use). We carried out the first broad-scale assessment of wildland fire patterns in northern Mexico to assess the relative influence of top-down and bottom-up drivers of fire in a...

  10. Does Locally Produced Food Create Loyalty?: An Investigation on Locavore Attitude As Control Variable

    OpenAIRE

    EROĞLU PEKTAŞ, Güzide Öncü; DURMAZ, Ahmet; YÜKSEL, Mehmet

    2017-01-01

    After locavore was chosen as “thebest word of the year” in 2007, its popularity increased gradually. Today greatnumber of locavores consciously prefer locally produced food for the benefit ofthemselves and their community. Undoubtedly this conscious movement has itsconsequences in marketing discipline. Accordingly, this paper is purposed toexamine the how locavore perceptions affect loyalty towards retailers that selllocally produced food. In this context, a survey was applied to people resid...

  11. Analysis of local control in patients with non-Hodgkin's lymphoma according to the WHO classification

    Energy Technology Data Exchange (ETDEWEB)

    Sakata, K.; Someya, M.; Nagakura, H.; Oouchi, A.; Nakata, K.; Koito, K.; Hareyama, M. [Dept. of Radiology, Sapporo Medical Univ., School of Medicine, Sapporo (Japan); Satoh, M. [Dept. of Clinical Pathology, Sapporo Medical Univ., School of Medicine, Sapporo (Japan); Kogawa, K. [Dept. of Fourth Internal Medicine, Sapporo Medical Univ., School of Medicine, Sapporo (Japan); Himi, T. [Dept. of Otorhinolaryngology, Sapporo Medical Univ., School of Medicine, Sapporo (Japan)

    2005-06-01

    Purpose: to analyze the influence of radiotherapy doses, chemotherapy doses, and clinical parameters on in-field disease control to assess the optimal radiation doses for treatment of non-Hodgkin's lymphoma according to the newly proposed WHO classification. Patients and methods: subjects consisted of 35 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type, 75 diffuse large B-cell lymphomas (DLBCL), 14 follicular lymphomas, 17 extranodal natural killer (NK)/T-cell lymphomas, nasal type, eight unclassified peripheral T-cell lymphomas, four anaplastic large-cell lymphomas, T/null cell type, and five others. 59 patients received radiotherapy alone. 98 patients received CHOP, modified CHOP, or more intensive chemotherapy, and six patients were treated with other combination. Results: no patients with MALT lymphoma had in-field local recurrence. There were no recurrences in DLBCL patients who received chemotherapy in which the doses of adriamycin were > 200 mg/m{sup 2}, nor in DLBCL patients who were treated with > 45 Gy. Only nine of 15 patients with T-cell lymphoma treated with {<=} 50 Gy and three of five patients treated with > 50 Gy had local control. The dose of adriamycin had no influence on local control of T-cell lymphoma. Conclusion: T/NK-cell lymphomas were more radioresistant than B-cell lymphomas. The prognosis for peripheral T/NK-cell lymphomas is poor even when treated by irradiation combined with chemotherapy. (orig.)

  12. Magnetic resonance guided focused ultrasound surgery (MRgFUS) of bone metastases: From primary pain palliation to local tumor control

    Science.gov (United States)

    Napoli, A.; Leonardi, A.; Andrani, F.; Boni, F.; Anzidei, M.; Catalano, C.

    2017-03-01

    Purpose: To evaluate the clinical performance of MRgFUS in primary pain palliation of painful bone metastases and in local tumor control. Materials and Methods: We enrolled 26 consecutive patients (female/male 12/14; age: 64.7±7.5yrs) with painful bone metastases. Before and 3 months after MRgFUS treatment pain severity and pain interference scores were assessed according to Brief Pain Inventory-Quality of Life (BPI-QoL) criteria and patients underwent both CT and MRI. Local tumor control was evaluated according to lesion size, density and perfusion at CT, dynamic contrast enhancement at MRI (Discovery 750HD, GE; Gd-Bopta, Bracco) and metabolic activity at PET or scintigraphy. Patients were classified as responders or non-responders. Results: No treatment-related adverse events were recorded during the study. As statistically significant difference between baseline and follow-up values for both pain severity and pain interference scores was observed (pmean SUV=1.2). Conclusion: MRgFUS can be safely and effectively used as the primary treatment for pain palliation in patients with painful bone metastases; moreover our experience demonstrated also a potential role for the MRgFUS in local tumor control.

  13. Water Rights Arenas in the Andes: Upscaling Networks to Strengthen Local Water Control

    Directory of Open Access Journals (Sweden)

    Rutgerd Boelens

    2008-06-01

    Full Text Available The threats that Andean water user collectives face are ever-growing in a globalising society. Water is power and engenders social struggle. In the Andean region, water rights struggles involve not only disputes over the access to water, infrastructure and related resources, but also over the contents of water rules and rights, the recognition of legitimate authority, and the discourses that are mobilised to sustain water governance structures and rights orders. While open and large-scale water battles such as Bolivia’s 'Water Wars' or nationwide mobilisations in Ecuador get the most public attention, low-profile and more localised water rights encounters, ingrained in local territories, are far more widespread and have an enormous impact on the Andean waterscapes. This paper highlights both water arenas and the ways they operate between the legal and the extralegal. It shows how local collectives build on their own water rights foundations to manage internal water affairs but which simultaneously offer an important home-base for strategising wider water defence manoeuvres. Hand-in-hand with inwardly reinforcing their rights bases, water user groups aim for horizontal and vertical linkages thereby creating strategic alliances. Sheltering an internal school for rights and identity development, reflection and organisation, these local community foundations, through open and subsurface linkages and fluxes, provide the groundwork for upscaling their water rights defence networks to national and transnational arenas.

  14. Distinct factors control histone variant H3.3 localization at specific genomic regions

    Science.gov (United States)

    Goldberg, Aaron D.; Banaszynski, Laura A.; Noh, Kyung-Min; Lewis, Peter W.; Elsaesser, Simon J.; Stadler, Sonja; Dewell, Scott; Law, Martin; Guo, Xingyi; Li, Xuan; Wen, Duancheng; Chapgier, Ariane; DeKelver, Russell C.; Miller, Jeffrey C.; Lee, Ya-Li; Boydston, Elizabeth A.; Holmes, Michael C.; Gregory, Philip D.; Greally, John M.; Rafii, Shahin; Yang, Chingwen; Scambler, Peter J.; Garrick, David; Gibbons, Richard J.; Higgs, Douglas R.; Cristea, Ileana M.; Urnov, Fyodor D.; Zheng, Deyou; Allis, C. David

    2010-01-01

    Summary The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem (ES) cells and neuronal precursor cells. Genome-wide patterns of H3.3 are dependent on amino acid sequence, and change with cellular differentiation at developmentally regulated loci. The H3.3 chaperone Hira is required for H3.3 enrichment at active and repressed genes. Strikingly, Hira is not essential for localization of H3.3 at telomeres and many transcription factor binding sites. Immunoaffinity purification and mass spectrometry reveal that the proteins Atrx and Daxx associate with H3.3 in a Hira-independent manner. Atrx is required for Hira-independent localization of H3.3 at telomeres, and for the repression of telomeric RNA. Our data demonstrate that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells. PMID:20211137

  15. Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria.

    Directory of Open Access Journals (Sweden)

    Silvia Ardissone

    2016-12-01

    Full Text Available Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypomethylation at specific loci, how and when these patterns are established during the cell cycle remains poorly characterized. Taking advantage of the small genomes and the synchronizability of α-proteobacteria, we discovered that conserved determinants of the cell cycle transcriptional circuitry establish specific hypomethylation patterns in the cell cycle model system Caulobacter crescentus. We used genome-wide methyl-N6-adenine (m6A- analyses by restriction-enzyme-cleavage sequencing (REC-Seq and single-molecule real-time (SMRT sequencing to show that MucR, a transcriptional regulator that represses virulence and cell cycle genes in S-phase but no longer in G1-phase, occludes 5'-GANTC-3' sequence motifs that are methylated by the DNA adenine methyltransferase CcrM. Constitutive expression of CcrM or heterologous methylases in at least two different α-proteobacteria homogenizes m6A patterns even when MucR is present and affects promoter activity. Environmental stress (phosphate limitation can override and reconfigure local hypomethylation patterns imposed by the cell cycle circuitry that dictate when and where local hypomethylation is instated.

  16. Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria.

    Science.gov (United States)

    Ardissone, Silvia; Redder, Peter; Russo, Giancarlo; Frandi, Antonio; Fumeaux, Coralie; Patrignani, Andrea; Schlapbach, Ralph; Falquet, Laurent; Viollier, Patrick H

    2016-12-01

    Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are established during the cell cycle remains poorly characterized. Taking advantage of the small genomes and the synchronizability of α-proteobacteria, we discovered that conserved determinants of the cell cycle transcriptional circuitry establish specific hypomethylation patterns in the cell cycle model system Caulobacter crescentus. We used genome-wide methyl-N6-adenine (m6A-) analyses by restriction-enzyme-cleavage sequencing (REC-Seq) and single-molecule real-time (SMRT) sequencing to show that MucR, a transcriptional regulator that represses virulence and cell cycle genes in S-phase but no longer in G1-phase, occludes 5'-GANTC-3' sequence motifs that are methylated by the DNA adenine methyltransferase CcrM. Constitutive expression of CcrM or heterologous methylases in at least two different α-proteobacteria homogenizes m6A patterns even when MucR is present and affects promoter activity. Environmental stress (phosphate limitation) can override and reconfigure local hypomethylation patterns imposed by the cell cycle circuitry that dictate when and where local hypomethylation is instated.

  17. Does excellence matter? The influence of potential for excellence on students’ motivation for specific collaborative tasks

    OpenAIRE

    Pullen, Annedien G.; Griffioen, Didi M. E.; Schoonenboom, Judith; Koning, Björn; Beishuizen, Jos J.

    2017-01-01

    textabstractIt is often assumed that students with a higher potential for excellence are less motivated to collaborate. So far, the question remains whether this is actually the case. This survey study investigated the influence of business students’ (N = 389) potential for excellence on their motivation to collaborate on a business-related task. Different aspects of potential for excellence were taken into account, including intelligence, creativity, first-year grade point average (GPA), and...

  18. Excel formulas and functions for dummies

    CERN Document Server

    Bluttman, Ken

    2013-01-01

    Learn to use Excel for practical, day-to-day calculations Excel is a powerful program with more than 300 built-in functions that can be used to perform an almost infinite number of calculations. This friendly book shows you how to use the 150 most valuable ones in real-world situations: to compare the cost of buying vs. leasing a car, calculate classroom grades, or evaluate investment performance, for example. Another 85 specialized functions are also described. Detailed, step-by-step instructions help you understand how functions work within formulas and how you can use them t

  19. A single bout of meditation biases cognitive control but not attentional focusing: Evidence from the global-local task.

    Science.gov (United States)

    Colzato, Lorenza S; van der Wel, Pauline; Sellaro, Roberta; Hommel, Bernhard

    2016-01-01

    Recent studies show that a single bout of meditation can impact information processing. We were interested to see whether this impact extends to attentional focusing and the top-down control over irrelevant information. Healthy adults underwent brief single bouts of either focused attention meditation (FAM), which is assumed to increase top-down control, or open monitoring meditation (OMM), which is assumed to weaken top-down control, before performing a global-local task. While the size of the global-precedence effect (reflecting attentional focusing) was unaffected by type of meditation, the congruency effect (indicating the failure to suppress task-irrelevant information) was considerably larger after OMM than after FAM. Our findings suggest that engaging in particular kinds of meditation creates particular cognitive-control states that bias the individual processing style toward either goal-persistence or cognitive flexibility. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Optimal climate control of a storage facility using local weather forecasts

    NARCIS (Netherlands)

    Keesman, K.J.; Peters, D.; Lukasse, L.J.S.

    2003-01-01

    in this paper, the problem of optimal climate control of a potato storage facility exploiting favourable weather conditions is considered. A receding horizon optimal controller, allowing incorporation of real-time weather forecasts and input/state constraints and based on a reduced-order model, is

  1. Using routinely collected data to evaluate a leaflet campaign to increase the presentation of people with memory problems to general practice: a locality based controlled study

    Directory of Open Access Journals (Sweden)

    Tom Chan

    2010-09-01

    Conclusions During a leaflet campaign the recording and management ofmemory problems increased. However, there was greater improvement in the control locality. This study demonstrates the importance of including a control group and the strengths of routine primary care data.

  2. Center of Excellence for Laser Applications in Medicine, Microlaser Microscope

    Energy Technology Data Exchange (ETDEWEB)

    Webb, R. H.

    2003-01-17

    The Center of Excellence for Laser Applications in Medicine at the Schepens Eye Research Institute (SERI) is a Center for: A core group of researchers who support each other and their various projects for real-time medical imaging and diagnostics in contiguous space at SERI. Clinical collaborators who participate in the core research at SERI, MEEI, and local ophthalmology practices, and at associated sites around the world. Industrial partners who transfer our technology to commercial products that will reach clinical usage everywhere. Students, post-doctoral associates and medical fellows who work with us and learn how to practice real-time medical imaging and diagnostics.

  3. Perceived control among migrant live-in and local live-out home care workers in Israel.

    Science.gov (United States)

    Shinan-Altman, Shiri; Ayalon, Liat

    2017-11-20

    To examine perceived control among live-in and live-out home care workers and to identify factors that contribute to perceived control among both types of caregiving. 338 migrant live-in home care workers and 185 local live-out home care workers were asked to report their perceived control. Burnout, satisfaction with the relationship with the care recipient and the care recipient's family, and satisfaction with social relationship were also gathered. Both types of caregivers reported high levels of perceived control, although live-in home care workers expressed more perceived control. Higher age, higher levels of satisfaction with the relationship with the care recipient and the care recipient's family and lower levels of burnout, predicted perceived control. Satisfaction with social relationship was a stronger predictor of one's perceived control among live-in home care workers. Promoting social relationships outside the home care context by allowing migrant live-in home care workers to take part in social gatherings is recommended as this can strengthen their sense of perceived control.

  4. American Brachytherapy Society Task Group Report: Long-term control and toxicity with brachytherapy for localized breast cancer.

    Science.gov (United States)

    Shaitelman, Simona F; Amendola, Beatriz; Khan, Atif; Beriwal, Sushil; Rabinovitch, Rachel; Demanes, D Jeffrey; Kim, Leonard H; Cuttino, Laurie

    There has been significant controversy regarding the equivalency of accelerated partial breast irradiation to whole-breast irradiation. With the recent publication of a large, randomized trial comparing these two treatment modalities, an update on the current state of knowledge of brachytherapy-based accelerated partial breast irradiation, with respect to local control and toxicities, would be useful to practitioners and patients. A systematic literature review was conducted examining articles published between January 2000 and April 2016 on the topics "brachytherapy" and "breast." A total of 67 articles met inclusion criteria, providing outcomes on local tumor control and/or toxicity for breast brachytherapy. Reported 5-year local failure rates were 1.4-6.1% for multicatheter interstitial brachytherapy (MIB) and 0-5.7% for single-entry brachytherapy catheters when delivered to patients with standard selection criteria. Toxicity profiles are acceptable, with cosmetic outcomes comparable to whole-breast irradiation. The reported rates of infection were 0-12%. Symptomatic fat necrosis was found in 0-12% and 0-3.2% of patients treated with MIB and single-entry brachytherapy catheters, respectively. Late Grade ≥3 telangiectasias and fibrosis were reported in 0-8% and 0-9.1% of patients treated with MIB, respectively. These side effects were less common with single-entry brachytherapy catheters (0-2.0% and 0%, respectively). Breast brachytherapy is a treatment technique that provides acceptable rates of local control in select patients, as demonstrated by Level I evidence. The side effect profile of this treatment is well documented and should be shared with patients when considering this treatment modality. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  5. Suspended graphene devices with local gate control on an insulating substrate.

    Science.gov (United States)

    Ong, Florian R; Cui, Zheng; Yurtalan, Muhammet A; Vojvodin, Cameron; Papaj, Michał; Orgiazzi, Jean-Luc F X; Deng, Chunqing; Bal, Mustafa; Lupascu, Adrian

    2015-10-09

    We present a fabrication process for graphene-based devices where a graphene monolayer is suspended above a local metallic gate placed in a trench. As an example we detail the fabrication steps of a graphene field-effect transistor. The devices are built on a bare high-resistivity silicon substrate. At temperatures of 77 K and below, we observe the field-effect modulation of the graphene resistivity by a voltage applied to the gate. This fabrication approach enables new experiments involving graphene-based superconducting qubits and nano-electromechanical resonators. The method is applicable to other two-dimensional materials.

  6. School Leadership: Handbook for Excellence. Second Edition.

    Science.gov (United States)

    Smith, Stuart C., Ed.; Piele, Philip K., Ed.

    Recognizing the importance of good leadership to the achievement of educational excellence, the second edition of this handbook synthesizes a large body of school leadership literature and explores the subject from three perspectives: the person, the structure, and the skills. Part I examines characteristics of today's educational leaders;…

  7. Center of Excellence for Hypersonics Research

    Science.gov (United States)

    2012-01-25

    American astronauts on the moon . These observations motivated the need for a Center of Excellence in the area of hypersonic flows to advance the state of...as well as argon-xenon and argon- helium mixtures. The data produced by such first-principles MD simulations is then used to improve DSMC collision

  8. [Bodily excellence and education: ambiguities of performance].

    Science.gov (United States)

    Queval, Isabelle

    2011-01-01

    The notion of excellence contains an ambivalence: to aim at the "good" and/or to aim at the "best". This ambivalence exists particularly in the physical effort and in the history of bodily practices, shared between gymnastics, physical education and sports. In the second part of the XXth century, the notion of performance became "worship of performance", "infinite perfectibility". In this context, high level sports became the human improvement laboratory, thanks to the sophistication of its technical means and the its practices intensity. However this "high" questions: about physical and psychological consequences of intensive practices ; about doping and its medical and ethical perspectives; about the increasing precociousness and the potential exploitation of the baby champions. It questions about the nature of familial, social, economical norms transmitted by education: about articulation between constraint and self-government. This is the question about the "price" of excellence. In this sense it appears that the excellence of champion spreads out the margins of an ethics which would be meant to be regulating and universal, indeed this excellence is perhaps, in the same capacity as genius is and in spite of the attachment of sports to a "ethics of the rule", un-ethical.

  9. Using Excel in Teacher Education for Sustainability

    Science.gov (United States)

    Aydin, Serhat

    2016-01-01

    In this study, the feasibility of using Excel software in teaching whole Basic Statistics Course and its influence on the attitudes of pre-service science teachers towards statistics were investigated. One hundred and two pre-service science teachers in their second year participated in the study. The data were collected from the prospective…

  10. Introduction to 3D Graphics through Excel

    Science.gov (United States)

    Benacka, Jan

    2013-01-01

    The article presents a method of explaining the principles of 3D graphics through making a revolvable and sizable orthographic parallel projection of cuboid in Excel. No programming is used. The method was tried in fourteen 90 minute lessons with 181 participants, which were Informatics teachers, undergraduates of Applied Informatics and gymnasium…

  11. Textbooks for Responsible Data Analysis in Excel

    Science.gov (United States)

    Garrett, Nathan

    2015-01-01

    With 27 million users, Excel (Microsoft Corporation, Seattle, WA) is the most common business data analysis software. However, audits show that almost all complex spreadsheets have errors. The author examined textbooks to understand why responsible data analysis is taught. A purposeful sample of 10 textbooks was coded, and then compared against…

  12. Schistosomacidal activity of Maytenus senegalensis (Lam.) Excell ...

    African Journals Online (AJOL)

    A study was conducted to investigate the schistosomacidal effect of Maytenus senegalensis (Lam.) Excell. on Schistosoma mansoni in mice. Three different concentrations (6.0, 3.0 and 1.5) mg/ml of the aqueous and ethanolic extracts of the plant roots was given orally to different groups of infected mice. Praziquantel was ...

  13. Excellence: The Key to Educating Visual Artists.

    Science.gov (United States)

    Rush, Jean C.; Conant, Howard

    1979-01-01

    The 1964-66 art education conferences were the last serious attempt to involve professional artists and educators in arts policy planning. This is a call to the art education profession to end this communication gap through a conference to examine the nature of excellence in the education of visual artists. (Author/SJL)

  14. Tips for Using Microsoft Excel in Assessment.

    Science.gov (United States)

    Kahan, David

    Acknowledging the need for additional practical resources for integrating technology into physical education assessment, this paper provides strategies and step-by-step instructions for incorporating Microsoft Excel into physical educators' assessment tools. The first section briefly reviews the literature on assessment in physical education. The…

  15. GUNSHOT FRACTURES OF TIBIA AND FEMUR - EXCELLENT ...

    African Journals Online (AJOL)

    2011-10-10

    Oct 10, 2011 ... GUNSHOT FRACTURES OF TIBIA AND FEMUR - EXCELLENT RESULTS WITH REAMED BONE MARROW GRAFT. AND INTERLOCKING .... between injury and surgery as well as associated injuries were documented. ..... injection in the treatment. of delayed and non-union in long bones. Singapore Med ...

  16. Expanding Educational Excellence: The Power of Schools

    Science.gov (United States)

    Coleman, Mary Ruth; Winn, Donna-Marie; Harradine, Christine

    2012-01-01

    In this paper, the authors explore four major barriers to academic success that must be addressed, briefly describe two projects that have worked to address these barriers, and make recommendations for moving forward as they work to expand educational excellence for all students. They provide examples of the myriad ways in which schools have the…

  17. Designing Quality Service: The Service Excellence Model.

    Science.gov (United States)

    Ellicott, Michael A.; Conard, Rodney J.

    1997-01-01

    Recent experiences of manufacturing and commercial service industries provide insights to college facilities managers for combining downsizing with quality improvement. The Service Excellence Model emphasizes creation of shared responsibility, focus on core service processes, empowerment of cross-functional process-improvement teams, performance…

  18. Humour: An Excellent EFL Teaching Device.

    Science.gov (United States)

    Guindal, Albert Lopez

    Humor is an excellent teaching tool because, in addition to preventing classroom boredom and monotony, it introduces lateral aspects of language such as irony, sarcasm, mockery, elision, ellipsis, and euphemism. Humor in language can be approached interactively or structurally through a variety of activities. It can be used to expand vocabulary,…

  19. MAINTAINING EXCELLENCE IN TEACHING OF HUMAN ANATOMY ...

    African Journals Online (AJOL)

    Kevin Wangwe Ongeti

    2013-01-02

    Jan 2, 2013 ... have resulted in wide disparities in curriculum design teaching methods, number and composition of instructors. Inspite of the challenges, the Department of Human Anatomy of the University of Nairobi. (UON) maintained excellence of teaching for over 40yrs. This article describes the teaching of anatomy.

  20. Primary cryoablation for Gleason 8, 9, or 10 localized prostate cancer: Biochemical and local control outcomes from the Cryo OnLine database registry

    Directory of Open Access Journals (Sweden)

    J Stephen Jones

    2008-01-01

    Results: The average age at treatment was 69.6 ± 8.2 years. Pretreatment PSA was 16.2 ± 17.9 ng/ml and the average Gleason was 8.5 ± 0.6. Patients were followed for 39.0 ± 18.8 months (range: 24-120 months and 5-year follow-up was available for 12 patients. Eight-seven percent of the patients achieved a PSA nadir < 0.4 ng/ml. Five-year actuarial biochemical survivals was 64.4 ± 6.0% and 44.6 ± 8.0% for the ASTRO and Phoenix definitions, respectively. A total of 47 underwent posttreatment biopsy. Of these, 12 showed evidence of disease resulting in a positive biopsy rate for those who underwent biopsy of 25.5%. This yields a positive biopsy rate of the entire population of 15.6% (12/77. Conclusions: Cryoablation, as a primary treatment for high-grade Gleason prostate cancer practiced over a wide spectrum of users provides definable biochemical and local control for a hard to manage patient population with aggressive disease.

  1. A randomized controlled clinical trial to evaluate blood pressure changes in patients undergoing extraction under local anesthesia with vasopressor use.

    Science.gov (United States)

    Uzeda, Marcelo José; Moura, Brenda; Louro, Rafael Seabra; da Silva, Licínio Esmeraldo; Calasans-Maia, Mônica Diuana

    2014-05-01

    The control of hypertensive patients' blood pressure and heart rate using vasoconstrictors during surgical procedures under anesthesia is still a major concern in everyday surgical practice. This clinical trial aimed to evaluate the variation of blood pressure and heart rate in nonhypertensive and controlled hypertensive voluntary subjects undergoing oral surgery under local anesthesia with lidocaine hydrochloride and epinephrine at 1:100,000 (Alphacaine; DFL, Brazil), performed in the Oral Surgery Department, Dentistry School, Fluminense Federal University. In total, 25 voluntary subjects were divided into 2 groups: nonhypertensive (n = 15) and controlled hypertensives (n = 10). Blood pressure and heart rate were measured at 4 different times: T0, in the waiting room; T1, after placement of the surgical drapes; T2, 10 minutes after anesthesia injection; and T3, at the end of the surgical procedure. A statistically significant difference (P 0.05) between the amount administered to nonhypertensive and hypertensive subjects. It was concluded that the local anesthetics studied could safely be used in controlled hypertensive and nonhypertensive patients in compliance with the maximum recommended doses.

  2. Response of SO2 and Particulate Air Pollution to Local and Regional Emission Controls: A Case Study in Maryland

    Science.gov (United States)

    He, Hao; Vinnikov, Konstantin Y.; Li, Can; Krotkov, Nickolay Anatoly; Jongeward, Andrew R.; Li, Zhanqing; Stehr, Jeffrey W.; Hains, Jennifer; Dickerson, RUssell R.

    2016-01-01

    This paper addresses the questions of what effect local regulations can have on pollutants with different lifetimes and how surface observations and remotely sensed data can be used to determine the impacts. We investigated the decadal trends of tropospheric sulfur dioxide (SO2) and aerosol pollution over Maryland and its surrounding states, using surface, aircraft, and satellite measurements. Aircraft measurements indicated fewer isolated SO2 plumes observed in summers, a 40 decrease of column SO2, and a 20 decrease of atmospheric optical depth (AOD) over Maryland after the implementation of local regulations on sulfur emissions from power plants (90 reduction from 2010). Surface observations of SO2 and particulate matter (PM) concentrations in Maryland show similar trends. OMI SO2 and MODIS AOD observations were used to investigate the column contents of air pollutants over the eastern U.S.; these indicate decreasing trends in column SO2 (60 decrease) and AOD (20 decrease). The decrease of upwind SO2 emissions also reduced aerosol loadings over the downwind Atlantic Ocean near the coast by 20, while indiscernible changes of the SO2 column were observed. A step change of SO2 emissions in Maryland starting in 20092010 had an immediate and profound benefit in terms of local surface SO2 concentrations but a modest impact on aerosol pollution, indicating that short-lived pollutants are effectively controlled locally, while long-lived pollutants require regional measures.

  3. Local control on precipitation in a fully coupled climate-hydrology model.

    Science.gov (United States)

    Larsen, Morten A D; Christensen, Jens H; Drews, Martin; Butts, Michael B; Refsgaard, Jens C

    2016-03-10

    The ability to simulate regional precipitation realistically by climate models is essential to understand and adapt to climate change. Due to the complexity of associated processes, particularly at unresolved temporal and spatial scales this continues to be a major challenge. As a result, climate simulations of precipitation often exhibit substantial biases that affect the reliability of future projections. Here we demonstrate how a regional climate model (RCM) coupled to a distributed hydrological catchment model that fully integrates water and energy fluxes between the subsurface, land surface, plant cover and the atmosphere, enables a realistic representation of local precipitation. Substantial improvements in simulated precipitation dynamics on seasonal and longer time scales is seen for a simulation period of six years and can be attributed to a more complete treatment of hydrological sub-surface processes including groundwater and moisture feedback. A high degree of local influence on the atmosphere suggests that coupled climate-hydrology models have a potential for improving climate projections and the results further indicate a diminished need for bias correction in climate-hydrology impact studies.

  4. Local maternal control of seed size by KLUH/CYP78A5-dependent growth signaling.

    Science.gov (United States)

    Adamski, Nikolai M; Anastasiou, Elena; Eriksson, Sven; O'Neill, Carmel M; Lenhard, Michael

    2009-11-24

    Seed development in plants involves the coordinated growth of the embryo, endosperm, and maternal tissue. Several genes have been identified that influence seed size by acting maternally, such as AUXIN RESPONSE FACTOR2, APETALA2, and DA1. However, given the lack of gain-of-function effects of these genes on seed size, it is unclear whether their activity levels are limiting in WT plants and whether they could thus be used to regulate seed size in development or evolution. Also, whether the altered seed sizes reflect local gene activity or global physiological changes is unknown. Here, we demonstrate that the cytochrome P450 KLUH (KLU) regulates seed size. KLU acts locally in developing flowers to promote seed growth, and its activity level is limiting for seed growth in WT. KLU is expressed in the inner integument of developing ovules, where it non-cell autonomously stimulates cell proliferation, thus determining the growth potential of the seed coat and seed. A KLU-induced increase in seed size leads to larger seedlings and higher relative oil content of the seeds. Genetic analyses indicate that KLU acts independently of other tested maternal factors that influence integument cell proliferation. Thus, the level of KLU-dependent growth factor signaling determines size in ovules and seeds, suggesting this pathway as a target for crop improvement.

  5. Biomaterials for Local, Controlled Drug Delivery to the Injured Spinal Cord.

    Science.gov (United States)

    Ziemba, Alexis M; Gilbert, Ryan J

    2017-01-01

    Affecting approximately 17,000 new people each year, spinal cord injury (SCI) is a devastating injury that leads to permanent paraplegia or tetraplegia. Current pharmacological approaches are limited in their ability to ameliorate this injury pathophysiology, as many are not delivered locally, for a sustained duration, or at the correct injury time point. With this review, we aim to communicate the importance of combinatorial biomaterial and pharmacological approaches that target certain aspects of the dynamically changing pathophysiology of SCI. After reviewing the pathophysiology timeline, we present experimental biomaterial approaches to provide local sustained doses of drug. In this review, we present studies using a variety of biomaterials, including hydrogels, particles, and fibers/conduits for drug delivery. Subsequently, we discuss how each may be manipulated to optimize drug release during a specific time frame following SCI. Developing polymer biomaterials that can effectively release drug to target specific aspects of SCI pathophysiology will result in more efficacious approaches leading to better regeneration and recovery following SCI.

  6. Biomaterials for Local, Controlled Drug Delivery to the Injured Spinal Cord

    Directory of Open Access Journals (Sweden)

    Alexis M. Ziemba

    2017-05-01

    Full Text Available Affecting approximately 17,000 new people each year, spinal cord injury (SCI is a devastating injury that leads to permanent paraplegia or tetraplegia. Current pharmacological approaches are limited in their ability to ameliorate this injury pathophysiology, as many are not delivered locally, for a sustained duration, or at the correct injury time point. With this review, we aim to communicate the importance of combinatorial biomaterial and pharmacological approaches that target certain aspects of the dynamically changing pathophysiology of SCI. After reviewing the pathophysiology timeline, we present experimental biomaterial approaches to provide local sustained doses of drug. In this review, we present studies using a variety of biomaterials, including hydrogels, particles, and fibers/conduits for drug delivery. Subsequently, we discuss how each may be manipulated to optimize drug release during a specific time frame following SCI. Developing polymer biomaterials that can effectively release drug to target specific aspects of SCI pathophysiology will result in more efficacious approaches leading to better regeneration and recovery following SCI.

  7. Nanospectroscopy of single quantum dots with local strain control using a phase-change mask

    Science.gov (United States)

    Saiki, Toshiharu; Shintani, Toshimichi; Kuwahara, Masashi; Regreny, Philippe; Gendry, Michel

    2017-08-01

    Herein, we describe a new technique that allows high-sensitivity near-field imaging spectroscopic analysis of individual quantum constituents in semiconductors. This method employs an optical mask composed of a phase-change material (PCM) and operates at optical telecommunication wavelengths. Superior collection efficiency and spatial resolution are achieved by using an amorphous nanoaperture as a result of the extreme optical contrast between the PCM in amorphous and crystalline phases at visible wavelengths and the good near-infrared transparency of this material. Fine tuning of quantum dot (QD) emission levels via localized strain as a result of the increase in volume of the PCM upon amorphization has also been demonstrated. Both red and blue shifts of the energy levels were predicted to occur beneath the flat and edge regions of the amorphous mask, respectively, using finite element simulations. The viability of localized strain tuning as an approach to nanospectroscopy employing phase changes was confirmed by measurements of the photoluminescence of individual InAs/InP QDs. In addition, the emission levels of two neighboring QDs were matched based on modifying the shift magnitudes and directions via careful adjustment of the indenter size and position.

  8. A public policy approach to local models of HIV/AIDS control in Brazil.

    Science.gov (United States)

    Le Loup, Guillaume; de Assis, Andreia; Costa-Couto, Maria-Helena; Thoenig, Jean-Claude; Fleury, Sonia; de Camargo, Kenneth; Larouzé, Bernard

    2009-06-01

    We investigated involvement and cooperation patterns of local Brazilian AIDS program actors and the consequences of these patterns for program implementation and sustainability. We performed a public policy analysis (documentary analysis, direct observation, semistructured interviews of health service and nongovernmental organization [NGO] actors) in 5 towns in 2 states, São Paulo and Pará. Patterns suggested 3 models. In model 1, local government, NGOs, and primary health care services were involved in AIDS programs with satisfactory response to new epidemiological trends but a risk that HIV/AIDS would become low priority. In model 2, mainly because of NGO activism, HIV/AIDS remained an exceptional issue, with limited responses to new epidemiological trends and program sustainability undermined by political instability. In model 3, involvement of public agencies and NGOs was limited, with inadequate response to epidemiological trends and poor mobilization threatening program sustainability. Within a common national AIDS policy framework, the degree of involvement and cooperation between public and NGO actors deeply impacts population coverage and program sustainability. Specific processes are required to maintain actor mobilization without isolating AIDS programs.

  9. Model-guided control of hippocampal discharges by local direct current stimulation.

    Science.gov (United States)

    Mina, Faten; Modolo, Julien; Recher, Fanny; Dieuset, Gabriel; Biraben, Arnaud; Benquet, Pascal; Wendling, Fabrice

    2017-05-10

    Neurostimulation is an emerging treatment for drug-resistant epilepsies when surgery is contraindicated. Recent clinical results demonstrate significant seizure frequency reduction in epileptic patients, however the mechanisms underlying this therapeutic effect are largely unknown. This study aimed at gaining insights into local direct current stimulation (LDCS) effects on hyperexcitable tissue, by i) analyzing the impact of electrical currents locally applied on epileptogenic brain regions, and ii) characterizing currents achieving an "anti-epileptic" effect (excitability reduction). First, a neural mass model of hippocampal circuits was extended to accurately reproduce the features of hippocampal paroxysmal discharges (HPD) observed in a mouse model of epilepsy. Second, model predictions regarding current intensity and stimulation polarity were confronted to in vivo mice recordings during LDCS (n = 8). The neural mass model was able to generate realistic hippocampal discharges. Simulation of LDCS in the model pointed at a significant decrease of simulated HPD (in duration and occurrence rate, not in amplitude) for cathodal stimulation, which was successfully verified experimentally in epileptic mice. Despite the simplicity of our stimulation protocol, these results contribute to a better understanding of clinical benefits observed in epileptic patients with implanted neurostimulators. Our results also provide further support for model-guided design of neuromodulation therapy.

  10. Controlled Release of Dexamethasone from Organosilicone Constructs for Local Modulation of Inflammation in Islet Transplantation.

    Science.gov (United States)

    Weaver, Jessica D; Song, Yun; Yang, Ethan Y; Ricordi, Camillo; Pileggi, Antonello; Buchwald, Peter; Stabler, Cherie L

    2015-08-01

    Inflammation is a significant detriment to the engraftment of cells and tissues, particularly for islet transplantation, where a low tolerance for the inflammatory milieu results in significant graft loss. Local treatment with anti-inflammatories, such as glucocorticoids, provides the benefits of site-targeted delivery with minimization of the broad side effects associated with systemic delivery. Polydimethylsiloxane (PDMS) is a flexible platform that is capable of providing sustained delivery of hydrophobic drugs. Here, we evaluated the capacity of PDMS constructs loaded with the anti-inflammatory glucocorticoid dexamethasone (Dex) to locally mitigate inflammation in islet grafts. Dex-PDMS constructs, fabricated in rod or disk geometries, demonstrated prolonged and sustained release at therapeutically relevant levels. In vitro, Dex-PDMS constructs inhibited endotoxin-induced human monocyte and macrophage activation, but they did not impair islet viability or function. Dex-PDMS rods, co-transplanted with islet-seeded scaffolds in a murine model, demonstrated suppression of host inflammatory responses during early- and late-phase engraftment, without significantly altering islet graft potency. The facile nature of these glucocorticoid-doped PDMS constructs allows for the optimization of targeted dose delivery with wide applicability in cell and tissue transplantation.

  11. Propensity score matching for selection of local areas as controls for evaluation of effects of alcohol policies in case series and quasi case-control designs.

    Science.gov (United States)

    de Vocht, F; Campbell, R; Brennan, A; Mooney, J; Angus, C; Hickman, M

    2016-03-01

    Area-level public health interventions can be difficult to evaluate using natural experiments. We describe the use of propensity score matching (PSM) to select control local authority areas (LAU) to evaluate the public health impact of alcohol policies for (1) prospective evaluation of alcohol policies using area-level data, and (2) a novel two-stage quasi case-control design. Ecological. Alcohol-related indicator data (Local Alcohol Profiles for England, PHE Health Profiles and ONS data) were linked at LAU level. Six LAUs (Blackpool, Bradford, Bristol, Ipswich, Islington, and Newcastle-upon-Tyne) as sample intervention or case areas were matched to two control LAUs each using PSM. For the quasi case-control study a second stage was added aimed at obtaining maximum contrast in outcomes based on propensity scores. Matching was evaluated based on average standardized absolute mean differences (ASAM) and variable-specific P-values after matching. The six LAUs were matched to suitable control areas (with ASAM values >0.05 indicating good matching) for a prospective evaluation study that sought areas that were similar at baseline in order to assess whether a change in intervention exposure led to a change in the outcome (alcohol related harm). PSM also generated appropriate matches for a quasi case-control study--whereby the contrast in health outcomes between cases and control areas needed to be optimized in order to assess retrospectively whether differences in intervention exposure were associated with the outcome. The use of PSM for area-level alcohol policy evaluation, but also for other public health interventions, will improve the value of these evaluations by objective and quantitative selection of the most appropriate control areas. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Subject-specific modulation of local field potential spectral power during brain-machine interface control in primates

    Science.gov (United States)

    So, Kelvin; Dangi, Siddharth; Orsborn, Amy L.; Gastpar, Michael C.; Carmena, Jose M.

    2014-04-01

    Objective. Intracortical brain-machine interfaces (BMIs) have predominantly utilized spike activity as the control signal. However, an increasing number of studies have shown the utility of local field potentials (LFPs) for decoding motor related signals. Currently, it is unclear how well different LFP frequencies can serve as features for continuous, closed-loop BMI control. Approach. We demonstrate 2D continuous LFP-based BMI control using closed-loop decoder adaptation, which adapts decoder parameters to subject-specific LFP feature modulations during BMI control. We trained two macaque monkeys to control a 2D cursor in a center-out task by modulating LFP power in the 0-150 Hz range. Main results. While both monkeys attained control, they used different strategies involving different frequency bands. One monkey primarily utilized the low-frequency spectrum (0-80 Hz), which was highly correlated between channels, and obtained proficient performance even with a single channel. In contrast, the other monkey relied more on higher frequencies (80-150 Hz), which were less correlated between channels, and had greater difficulty with control as the number of channels decreased. We then restricted the monkeys to use only various sub-ranges (0-40, 40-80, and 80-150 Hz) of the 0-150 Hz band. Interestingly, although both monkeys performed better with some sub-ranges than others, they were able to achieve BMI control with all sub-ranges after decoder adaptation, demonstrating broad flexibility in the frequencies that could potentially be used for LFP-based BMI control. Significance. Overall, our results demonstrate proficient, continuous BMI control using LFPs and provide insight into the subject-specific spectral patterns of LFP activity modulated during control.

  13. Control of Microstructures and the Practical Properties of API X80 Grade Heavy-Wall High-Frequency Electric Resistance-Welded Pipe with Excellent Low-Temperature Toughness

    Science.gov (United States)

    Goto, Sota; Nakata, Hiroshi; Toyoda, Shunsuke; Okabe, Takatoshi; Inoue, Tomohiro

    2017-10-01

    This paper describes development of heavy-walled API X80 grade high-frequency electric resistance-welded (HFW) line pipes and conductor-casing pipes with wall thicknesses up to 20.6 mm. A fine bainitic-ferrite microstructure, which is preferable for low-temperature toughness, was obtained by optimizing the carbon content and applying the thermomechanical controlled hot-rolling process. As a result, the Charpy ductile-brittle transition temperature (DBTT) was well below 227 K (-46 °C) in the base metal of the HFW line pipe. When the controlled hot-rolling ratio (CR) was increased from 23 to 48 pct, the area average grain size decreased from 15 to 8 μm. The dependence of CTOD properties on CR was caused by the largest grain which is represented by the area average grain size. No texture development due to the increase of CR from 23 to 48 pct was observed. In addition, because controlled in-line heat treatment of the longitudinal weld seam also produced the fine bainitic-ferrite microstructure at the weld seam, DBTT was lower than 227 K (-46 °C) at the weld portion. The developed pipes showed good girth weldability without preheat treatment, and fracture in the tensile test initiated from the base metal in all cases.

  14. Proposal for a Venture Capital Grant: A Programmatic Approach to Excellence in Illinois Public Schools.

    Science.gov (United States)

    Hickrod, G. Alan; And Others

    A new formula proposed for categorically funding local education programs in Illinois can channel more money into programs for excellence than can general purpose grants. The formula, which would provide venture capital to stimulate local initiatives, would depend on district plans for using the money to improve instruction and on distribution of…

  15. Is remote stretching based on myofascial chains as effective as local exercise? A randomised-controlled trial.

    Science.gov (United States)

    Wilke, J; Vogt, L; Niederer, D; Banzer, W

    2017-10-01

    Lower limb stretching based on myofascial chains has been demonstrated to increase cervical range of motion (ROM) in the sagittal plane. It is, however, unknown whether such remote exercise is as effective as local stretching. To resolve this research deficit, 63 healthy participants (36 ± 13 years, ♂32) were randomly assigned to one of three groups: remote stretching of the lower limb (LLS), local stretching of the cervical spine (CSS) or inactive control (CON). Prior (M1), immediately post (M2) and 5 min following intervention (M3), maximal cervical ROM was assessed. Non-parametric data analysis (Kruskal-Wallis tests and adjusted post hoc Dunn tests) revealed significant differences between the disposed conditions. With one exception (cervical spine rotation after CSS at M2, P > .05), both LLS and CSS increased cervical ROM compared to the control group in all movement planes and at all measurements (P  .05). Lower limb stretching based on myofascial chains induces similar acute improvements in cervical ROM as local exercise. Therapists might consequently consider its use in programme design. However, as the attained effects do not seem to be direction-specific, further research is warranted in order to provide evidence-based recommendations.

  16. Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

    Directory of Open Access Journals (Sweden)

    Kim Ji-Young

    2010-06-01

    Full Text Available Abstract Background To investigate the efficacy and safety of accelerated partial breast irradiation (APBI via high-dose-rate (HDR multicatheter interstitial brachytherapy for early-stage breast cancer. Methods Between 2002 and 2006, 48 prospectively selected patients with early-stage breast cancer received APBI using multicatheter brachytherapy following breast-conserving surgery. Their median age was 52 years (range 36-78. A median of 34 Gy (range 30-34 in 10 fractions given twice daily within 5 days was delivered to the tumor bed plus a 1-2 cm margin. Most (92% patients received adjuvant systemic treatments. The median follow-up was 53 months (range 36-95. Actuarial local control rate was estimated from surgery using Kaplan-Meier method. Results Local recurrence occurred in two patients. Both were true recurrence/marginal miss and developed in patients with close ( Conclusions APBI using HDR multicatheter brachytherapy yielded local control, toxicity, and cosmesis comparable to those of conventional whole breast irradiation for select early-stage breast cancer. Patients with close resection margins may be ineligible for APBI.

  17. Does excellence matter? The influence of potential for excellence on students’ motivation for specific collaborative tasks

    NARCIS (Netherlands)

    A.G. Pullen (Annedien G.); D.M.E. Griffioen (Didi M. E.); J. Schoonenboom (Judith); B.B. de Koning (Björn); J.J. Beishuizen (Jos J.)

    2017-01-01

    textabstractIt is often assumed that students with a higher potential for excellence are less motivated to collaborate. So far, the question remains whether this is actually the case. This survey study investigated the influence of business students’ (N = 389) potential for excellence on their

  18. Statistical atmospheric inversion of local gas emissions by coupling the tracer release technique and local-scale transport modelling: a test case with controlled methane emissions

    Directory of Open Access Journals (Sweden)

    S. Ars

    2017-12-01

    Full Text Available This study presents a new concept for estimating the pollutant emission rates of a site and its main facilities using a series of atmospheric measurements across the pollutant plumes. This concept combines the tracer release method, local-scale atmospheric transport modelling and a statistical atmospheric inversion approach. The conversion between the controlled emission and the measured atmospheric concentrations of the released tracer across the plume places valuable constraints on the atmospheric transport. This is used to optimise the configuration of the transport model parameters and the model uncertainty statistics in the inversion system. The emission rates of all sources are then inverted to optimise the match between the concentrations simulated with the transport model and the pollutants' measured atmospheric concentrations, accounting for the transport model uncertainty. In principle, by using atmospheric transport modelling, this concept does not strongly rely on the good colocation between the tracer and pollutant sources and can be used to monitor multiple sources within a single site, unlike the classical tracer release technique. The statistical inversion framework and the use of the tracer data for the configuration of the transport and inversion modelling systems should ensure that the transport modelling errors are correctly handled in the source estimation. The potential of this new concept is evaluated with a relatively simple practical implementation based on a Gaussian plume model and a series of inversions of controlled methane point sources using acetylene as a tracer gas. The experimental conditions are chosen so that they are suitable for the use of a Gaussian plume model to simulate the atmospheric transport. In these experiments, different configurations of methane and acetylene point source locations are tested to assess the efficiency of the method in comparison to the classic tracer release technique in coping

  19. Final Results of Local-Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Beitler, Jonathan J., E-mail: jjbeitl@emory.edu [Winship Cancer Institute of Emory University School of Medicine, Atlanta, Georgia (United States); Zhang, Qiang [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States); Fu, Karen K. [University of California San Francisco, San Francisco, California (United States); Trotti, Andy [H. Lee Moffitt Cancer Center at the University of South Florida, Tampa, Florida (United States); Spencer, Sharon A. [University of Alabama at Birmingham Medical Center, Birmingham, Alabama (United States); Jones, Christopher U. [Radiological Associates of Sacramento, Sacramento, California (United States); Garden, Adam S. [MD Anderson Cancer Center, University of Texas, Houston, Texas (United States); Shenouda, George [McGill University, Montréal, Quebec (Canada); Harris, Jonathan [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States); Ang, Kian K. [MD Anderson Cancer Center, University of Texas, Houston, Texas (United States)

    2014-05-01

    Purpose: To test whether altered radiation fractionation schemes (hyperfractionation [HFX], accelerated fractionation, continuous [AFX-C], and accelerated fractionation with split [AFX-S]) improved local-regional control (LRC) rates for patients with squamous cell cancers (SCC) of the head and neck when compared with standard fractionation (SFX) of 70 Gy. Methods and Materials: Patients with stage III or IV (or stage II base of tongue) SCC (n=1076) were randomized to 4 treatment arms: (1) SFX, 70 Gy/35 daily fractions/7 weeks; (2) HFX, 81.6 Gy/68 twice-daily fractions/7 weeks; (3) AFX-S, 67.2 Gy/42 fractions/6 weeks with a 2-week rest after 38.4 Gy; and (4) AFX-C, 72 Gy/42 fractions/6 weeks. The 3 experimental arms were to be compared with SFX. Results: With patients censored for LRC at 5 years, only the comparison of HFX with SFX was significantly different: HFX, hazard ratio (HR) 0.79 (95% confidence interval 0.62-1.00), P=.05; AFX-C, 0.82 (95% confidence interval 0.65-1.05), P=.11. With patients censored at 5 years, HFX improved overall survival (HR 0.81, P=.05). Prevalence of any grade 3, 4, or 5 toxicity at 5 years; any feeding tube use after 180 days; or feeding tube use at 1 year did not differ significantly when the experimental arms were compared with SFX. When 7-week treatments were compared with 6-week treatments, accelerated fractionation appeared to increase grade 3, 4 or 5 toxicity at 5 years (P=.06). When the worst toxicity per patient was considered by treatment only, the AFX-C arm seemed to trend worse than the SFX arm when grade 0-2 was compared with grade 3-5 toxicity (P=.09). Conclusions: At 5 years, only HFX improved LRC and overall survival for patients with locally advanced SCC without increasing late toxicity.

  20. Local control on precipitation in a fully coupled climate-hydrology model

    DEFF Research Database (Denmark)

    Larsen, Morten A. D.; Christensen, Jens H.; Drews, Martin

    2016-01-01

    The ability to simulate regional precipitation realistically by climate models is essential to understand and adapt to climate change. Due to the complexity of associated processes, particularly at unresolved temporal and spatial scales this continues to be a major challenge. As a result, climate...... simulations of precipitation often exhibit substantial biases that affect the reliability of future projections. Here we demonstrate how a regional climate model (RCM) coupled to a distributed hydrological catchment model that fully integrates water and energy fluxes between the subsurface, land surface......, plant coverand the atmosphere, enables a realistic representation of local precipitation. Substantial improvements in simulated precipitation dynamics on seasonal and longer time scales is seen for a simulation period of six years and can be attributed to a more complete treatment of hydrological sub...

  1. Quality-of-service control in GRAMS for ATM local area network

    Science.gov (United States)

    Hui, Joseph Y.; Zhang, Junbiao; Li, Jun

    1995-05-01

    Gopher-style real-time ATM multimedia services (GRAMS) is a system designed for an ATM local area network, with the server providing multimedia services to multiple users in real-time, while the network bandwidth and the host capacity are fully exploited. Therefore, a server that can determine the service rates, and successfully multiplex media transmissions according to the quality-of-service (QoS) requirement of each request is a key component of this system. Proposed in this paper is a simple yet effective way to measure QoS in the GRAMS system. Experimental results are also presented, showing the feasibility of simultaneously providing tens of video and image transfer sessions using low-cost workstation technology.

  2. Nebulized versus Standard Local Application of Lidocaine during Flexible Bronchoscopy: A Randomized Controlled Trial.

    Science.gov (United States)

    Dreher, Michael; Cornelissen, Christian Gabriel; Reddemann, Manuel Armin; Müller, Annegret; Hübel, Christian; Müller, Tobias

    2016-01-01

    Endobronchial administration of local anesthetics such as lidocaine is often used for cough suppression during bronchoscopy. To achieve a better distribution of lidocaine in the tracheobronchial tree, spray catheters have been developed, allowing nebulization of the local anesthetic solution. However, there are little data on the efficacy and safety of this approach, or on the consumption of sedative drugs and lidocaine during nebulized administration. To investigate the tolerability of nebulized lidocaine compared to conventional lidocaine administration via syringe through the working channel of the bronchoscope in patients undergoing bronchoscopy. Consumption of sedative drugs and lidocaine was also compared between the two lidocaine administration approaches. Patients requiring bronchoscopy with endobronchial or transbronchial biopsy were randomly assigned to receive topical lidocaine either via syringe or via nebulizer. Endpoints were consumption of lidocaine and sedative drugs, as well as patient tolerance and safety. Thirty patients were included, 15 in each group. Patients in the nebulizer group required lower doses of endobronchial lidocaine (184.7 ± 67.98 vs. 250.7 ± 21.65 mg, p = 0.0045) and intravenous fentanyl (0.033 ± 0.041 vs. 0.067 ± 0.045 mg, p = 0.0236) than those in the syringe group; midazolam or propofol dosages did not differ between the two groups. In addition, there were no between-group differences in patient tolerance or safety (all p > 0.05). Endobronchial administration of lidocaine during bronchoscopy via nebulizer was found to be well tolerated and safe and was associated with reduced lidocaine and fentanyl dosages compared to administration via syringe. © 2016 S. Karger AG, Basel.

  3. Impact of radiation dose and standardized uptake value of (18)FDG PET on nodal control in locally advanced cervical cancer.

    Science.gov (United States)

    Ramlov, Anne; Kroon, Petra S; Jürgenliemk-Schulz, Ina M; De Leeuw, Astrid A C; Gormsen, Lars Christian; Fokdal, Lars Ulrik; Tanderup, Kari; Lindegaard, Jacob Christian

    2015-01-01

    Despite local control now exceeding 90% with image-guided adaptive brachytherapy (IGABT), regional and distant metastases continue to curb survival in locally advanced cervical cancer. As regional lymph nodes often represent first site of metastatic spread, improved nodal control could improve survival. The aim of this study was to examine optimal volume and dose of external beam radiotherapy (EBRT) to maximize regional control including dose contribution from IGABT. In total 139 patients from the EMBRACE study were analyzed. Individual nodal dose was determined by dose-maps from EBRT and IGABT. All PET/CT scans were re-evaluated and nodal maximal standard uptake value (SUVmax) was determined. Nodal failures were registered to planning scans and related to boosted nodes and treated volume. Relation between SUVmax and nodal control as well as the pattern of regional nodal failure were analyzed. Eighty-four patients were node positive. Nine patients had all metastatic nodes surgically removed. Seventy-five patients had 209 nodes boosted with EBRT. Median nodal boost dose was 62 Gy EQD2 (53-69 Gy EQD2). Median SUVmax was 6 (2-22). No patients had persistent nodal disease, but six patients recurred in a boosted node. SUVmax was significantly higher in nodes that recurred (p = 0.02). However, there was no correlation to nodal dose or volume. Twenty-one patients had a nodal failure including para-aortic nodal (PAN) metastases above the irradiated volume. Nine patients had a PAN-only failure. Patients receiving ≤ 4 cycles of weekly cisplatin had higher risk of nodal failure (p < 0.01). Current RT practice provides a high level of control in both boosted nodes and the elective irradiated regional target. However, a high nodal SUVmax is a negative prognostic predictor for nodal control. Attention should be raised to administration of a complete schedule of concurrent chemotherapy as well as treatment of para-aortic nodes.

  4. Localized Power Control for Multihop Large-Scale Internet of Things

    KAUST Repository

    Bader, Ahmed

    2015-08-04

    In this paper, we promote the use of multihop networking in the context of large-scale Internet of Things (IoT). Recognizing concerns related to the scalability of classical multihop routing and medium access techniques, we advocate the use of blind cooperation in conjunction with multihop communications. However, we show that blind cooperation is actually inefficient unless power control is applied. Inefficiency in this paper is projected in terms of the transport rate normalized to energy consumption. To that end, we propose an uncoordinated power control mechanism whereby each device in a blind cooperative cluster randomly adjusts its transmit power level. We derive an upper bound on the mean transmit power that must be observed at each device. We also devise a practical mechanism for each device to infer about the size of its neighborhood; a requirement necessary for the operation of the power control scheme. Finally, we assess the performance of the developed power control mechanism and demonstrate how it consistently outperforms the point-to-point case.

  5. Localized Power Control for Multihop Large-Scale Internet of Things

    KAUST Repository

    Bader, Ahmed

    2015-07-07

    In this paper, we promote the use of multihop networking in the context of large-scale Internet of Things (IoT). Recognizing concerns related to the scalability of classical multihop routing and medium access techniques, we advocate the use of blind cooperation in conjunction with multihop communications. However, we show that blind cooperation is actually inefficient unless power control is applied. Inefficiency in this paper is projected in terms of the transport rate normalized to energy consumption. To that end, we propose an uncoordinated power control mechanism whereby each device in a blind cooperative cluster randomly adjusts its transmit power level. We derive an upper bound on the mean transmit power that must be observed at each device. We also devise a practical mechanism for each device to infer about the size of its neighborhood; a requirement necessary for the operation of the power control scheme. Finally, we assess the performance of the developed power control mechanism and demonstrate how it consistently outperforms the point-to-point case.

  6. Fuzzy logic congestion control in IEEE 802.11 wireless local area networks: A performance evaluation

    CSIR Research Space (South Africa)

    Nyirenda, CN

    2007-09-01

    Full Text Available to the wireless network. Therefore, the implementation of a congestion control mechanism in Access Points promises to be a suitable solution. Recently, a particle swarm optimized Fuzzy Logic Congestion Detection (FLCD) was proposed for IP networks. This algorithm...

  7. Simulasi Virtual Local Area Network (VLAN Berbasis Software Defined Network (SDN Menggunakan POX Controller

    Directory of Open Access Journals (Sweden)

    Rohmat Tulloh

    2015-11-01

    Full Text Available VLAN (Virtual LAN merupakan sebuah teknologi yang dapat mengkonfigurasi jaringan logis independen dari struktur jaringan fisik. Hasil dari penelitian sebelumnya sudah diprediksi bahwa dibutuhkan Virtual Network yang akhirnya terciptalah VLAN. Namun paradigma jaringan saat ini tidak flexible, ketergantungan terhadap vendor sangat besar karena fungsi data plane dan control plane berada dalam satu paket device. SDN (Software defined network yang merupakan salahsatu evolusi teknologi jaringan sesuai dengan tuntutan yang berkembang dimana memisahkan fungsi data plane dan control plane pada suatu perangkat. POX Controller digunakan untuk men-simulasikan dan menguji Platform SDN (Software defined network. Pada penelitian ini menggunakan Openflow versi 1.0 untuk memasang header VLAN sehingga penelitian ini difokuskan untuk mengevaluasi performa forwarding VLAN yang memanfaatkan Openflow sebagai control plane dapat berfungsi dengan baik. Hasil penelitian ini mengusulkan penerapan karakteristik teknologi VLAN pada SDN karena telah berjalan dengan benar sesuai hasil pengujian konektifitas, verifikasi dan keamanan. Kemudian hasil pengujian lanjutan untuk melihat pengaruh SDN dengan skenario penambahan jumlah VLAN ID didapatkan bahwa set-up time akan bertambah seiring meningkatnya jumlah host dan dengan menggunakan protokol OpenFlow, latency yang terjadi di jaringan dapat dipantau dengan parameter round trip time (RTT yang stabil direntang 0,2 sampai 6 second walaupun jumlah vlan_id dan background traffic bertambah.

  8. Controlling and optimizing of energy streams in local buildings in a field test

    NARCIS (Netherlands)

    Bakker, Vincent; Molderink, Albert; Nykamp, Stefan; Hurink, Johann L.; Smit, Gerardus Johannes Maria; Reinelt, Jens

    2013-01-01

    Demand side management is one of the novel techniques enabled by introducing ICT in the distribution grid. Controllable assets and energy buffers make it possible to maintain a properly functioning grid, improve the efficiency of the grid and prolong the current grid infrastructure. This work

  9. Control local en el espacio de estados para un prototipo real de péndulo invertido traslacional

    Directory of Open Access Journals (Sweden)

    Lyda Vanessa Herrera Sepúlveda

    2014-07-01

    Full Text Available Este artículo aborda la readecuación de un prototipo de laboratorio para péndulo invertido traslacional, buscando recobrar su capacidad funcional y ejercer control local para mantener erguido el brazo del péndulo. En términos de control, el problema que se va a resolver será la viabilidad de una técnica de control por realimentación de estados en el prototipo experimental empleando un dispositivo de proceso de bajo costo. Se realizó por tanto, el diseño y la implementación de circuitos para el acondicionamiento de señales entre los dispositivos de medida, actuación y control. Se diseñó e implementó una estrategia de control por realimentación de estados en un microcontrolador Arduino Mega. Los resultados de simulación predicen la regulación del estado, que posteriormente fue corroborada de manera experimental con el prototipo de laboratorio. Actividades complementarias incluyen el análisis de técnicas avanzadas de control sobre el sistema, al igual que la inclusión de términos de no-linealidad en los modelos.

  10. Effect of Facilitation of Local Maternal-and-Newborn Stakeholder Groups on Neonatal Mortality: Cluster-Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Lars Åke Persson

    Full Text Available BACKGROUND: Facilitation of local women's groups may reportedly reduce neonatal mortality. It is not known whether facilitation of groups composed of local health care staff and politicians can improve perinatal outcomes. We hypothesised that facilitation of local stakeholder groups would reduce neonatal mortality (primary outcome and improve maternal, delivery, and newborn care indicators (secondary outcomes in Quang Ninh province, Vietnam. METHODS AND FINDINGS: In a cluster-randomized design 44 communes were allocated to intervention and 46 to control. Laywomen facilitated monthly meetings during 3 years in groups composed of health care staff and key persons in the communes. A problem-solving approach was employed. Births and neonatal deaths were monitored, and interviews were performed in households of neonatal deaths and of randomly selected surviving infants. A latent period before effect is expected in this type of intervention, but this timeframe was not pre-specified. Neonatal mortality rate (NMR from July 2008 to June 2011 was 16.5/1,000 (195 deaths per 11,818 live births in the intervention communes and 18.4/1,000 (194 per 10,559 live births in control communes (adjusted odds ratio [OR] 0.96 [95% CI 0.73-1.25]. There was a significant downward time trend of NMR in intervention communes (p = 0.003 but not in control communes (p = 0.184. No significant difference in NMR was observed during the first two years (July 2008 to June 2010 while the third year (July 2010 to June 2011 had significantly lower NMR in intervention arm: adjusted OR 0.51 (95% CI 0.30-0.89. Women in intervention communes more frequently attended antenatal care (adjusted OR 2.27 [95% CI 1.07-4.8]. CONCLUSIONS: A randomized facilitation intervention with local stakeholder groups composed of primary care staff and local politicians working for three years with a perinatal problem-solving approach resulted in increased attendance to antenatal care and reduced

  11. Continued benefits of a technical assistance web site to local tobacco control coalitions during a state budget shortfall.

    Science.gov (United States)

    Buller, David B; Young, Walter F; Bettinghaus, Erwin P; Borland, Ron; Walther, Joseph B; Helme, Donald; Andersen, Peter A; Cutter, Gary R; Maloy, Julie A

    2011-01-01

    A state budget shortfall defunded 10 local tobacco coalitions during a randomized trial but defunded coalitions continued to have access to 2 technical assistance Web sites. To test the ability of Web-based technology to provide technical assistance to local tobacco control coalitions. Randomized 2-group trial with local tobacco control coalitions as the unit of randomization. Local communities (ie, counties) within the State of Colorado. Leaders and members in 34 local tobacco control coalitions funded by the state health department in Colorado. Two technical assistance Web sites: A Basic Web site with text-based information and a multimedia Enhanced Web site containing learning modules, resources, and communication features. Use of the Web sites in minutes, pages, and session and evaluations of coalition functioning on coalition development, conflict resolution, leadership satisfaction, decision-making satisfaction, shared mission, personal involvement, and organization involvement in survey of leaders and members. Coalitions that were defunded but had access to the multimedia Enhanced Web site during the Fully Funded period and after defunding continued to use it (treatment group × funding status × period, F(3,714) = 3.18, P = .0234). Coalitions with access to the Basic Web site had low Web site use throughout and use by defunded coalitions was nearly zero when funding ceased. Members in defunded Basic Web site coalitions reported that their coalitions functioned worse than defunded Enhanced Web site coalitions (coalition development: group × status, F(1,360) = 4.81, P = .029; conflict resolution: group × status, F(1,306) = 5.69, P = .018; leadership satisfaction: group × status, F(1,342) = 5.69, P = .023). The Enhanced Web site may have had a protective effect on defunded coalitions. Defunded coalitions may have increased their capacity by using the Enhanced Web site when fully funded or by continuing to use the available online resources after defunding

  12. Sidewall electrode TiO x /TiO x N y resistive random access memory with excellent memory window control and reliability using plasma oxidation and a novel degradation-detecting writing algorithm

    Science.gov (United States)

    Lai, Erh-Kun; Lee, Dai-Ying; Wu, Jau-Yi; Lee, Ming-Hsiu; Khwa, Win-San; Lin, Yu-Hsuan; Chen, Wei-Chen; Chiang, Kuang-Hao; Horng, Sheng-Fu; Gong, Jeng; Lung, Hsiang-Lan; Hsieh, Kuang-Yeu; Lu, Chih-Yuan

    2017-04-01

    A TiO x /TiO x N y resistive random access memory (ReRAM) with a sidewall bottom electrode (BE) is demonstrated for the first time. Several interesting characteristics that are very desirable for high reliability memory applications are observed: (1) a stable RESET and SET resistance switching window even without write verification, (2) good 250 °C data retention, (3) ReRAM switching instability after cycling is monitored and corrected, resulting in good reliability, and (4) using only complementary metal oxide semiconductor (CMOS) familiar materials and processes, thus very manufacture-friendly. The thickness and quality of TiO x and TiO x N y are well controlled by plasma oxidation, and a large resistance switching window (>10×), a low operation voltage, and good reliability are realized.

  13. Efficacy of local neem extracts for sustainable malaria vector control in an African village

    Directory of Open Access Journals (Sweden)

    Duchemin Jean-Bernard

    2008-07-01

    Full Text Available Abstract Background Larval control of malaria vectors has been historically successful in reducing malaria transmission, but largely fell out of favour with the introduction of synthetic insecticides and bed nets. However, an integrated approach to malaria control, including larval control methods, continues to be the best chance for success, in view of insecticide resistance, the behavioural adaptation of the vectors to changing environments and the difficulties of reaching the poorest populations most at risk,. Laboratory studies investigating the effects of neem seed (Azadirachta indica extracts on Anopheles larvae have shown high rates of larval mortality and reductions in adult longevity, as well as low potential for resistance development. Methods This paper describes a method whereby seeds of the neem tree can be used to reduce adult Anopheles gambiae s.l. abundance in a way that is low cost and can be implemented by residents of rural villages in western Niger. The study was conducted in Banizoumbou village, western Niger. Neem seeds were collected from around the village. Dried seeds were ground into a coarse powder, which was then sprinkled onto known Anopheles larvae breeding habitats twice weekly during the rainy season 2007. Adult mosquitoes were captured on a weekly basis in the village and captures compared to those from 2005 and 2006 over the same period. Adult mosquitoes were also captured in a nearby village, Zindarou, as a control data set and compared to those from Banizoumbou. Results It was found that twice-weekly applications of the powder to known breeding habitats of Anopheles larvae in 2007 resulted in 49% fewer adult female Anopheles gambiae s.l. mosquitoes in Banizoumbou, compared with previous captures under similar environmental conditions and with similar habitat characteristics in 2005 and 2006. The productivity of the system in 2007 was found to be suppressed compared to the mean behaviour of 2005 and 2006 in

  14. Efficacy of local neem extracts for sustainable malaria vector control in an African village.

    Science.gov (United States)

    Gianotti, Rebecca L; Bomblies, Arne; Dafalla, Mustafa; Issa-Arzika, Ibrahim; Duchemin, Jean-Bernard; Eltahir, Elfatih Ab

    2008-07-23

    Larval control of malaria vectors has been historically successful in reducing malaria transmission, but largely fell out of favour with the introduction of synthetic insecticides and bed nets. However, an integrated approach to malaria control, including larval control methods, continues to be the best chance for success, in view of insecticide resistance, the behavioural adaptation of the vectors to changing environments and the difficulties of reaching the poorest populations most at risk. Laboratory studies investigating the effects of neem seed (Azadirachta indica) extracts on Anopheles larvae have shown high rates of larval mortality and reductions in adult longevity, as well as low potential for resistance development. This paper describes a method whereby seeds of the neem tree can be used to reduce adult Anopheles gambiae s.l. abundance in a way that is low cost and can be implemented by residents of rural villages in western Niger. The study was conducted in Banizoumbou village, western Niger. Neem seeds were collected from around the village. Dried seeds were ground into a coarse powder, which was then sprinkled onto known Anopheles larvae breeding habitats twice weekly during the rainy season 2007. Adult mosquitoes were captured on a weekly basis in the village and captures compared to those from 2005 and 2006 over the same period. Adult mosquitoes were also captured in a nearby village, Zindarou, as a control data set and compared to those from Banizoumbou. It was found that twice-weekly applications of the powder to known breeding habitats of Anopheles larvae in 2007 resulted in 49% fewer adult female Anopheles gambiae s.l. mosquitoes in Banizoumbou, compared with previous captures under similar environmental conditions and with similar habitat characteristics in 2005 and 2006. The productivity of the system in 2007 was found to be suppressed compared to the mean behaviour of 2005 and 2006 in Banizoumbou, whereas no change was found in Zindarou. With

  15. Samuel P. Massie Chair of Excellence Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, James H. [Howard Univ., Washington, DC (United States)

    2014-12-01

    Abstract In 1994 the Department of Energy established the DOE Chair of Excellence Professorship in Environmental Disciplines Program. In 2004, the Massie Chair of Excellence Professor at Howard University transitioned from Dr. Edward Martin to Dr. James H. Johnson, Jr. At the time of his appointment Dr. Johnson served as professor of civil engineering and Dean of the College of Engineering, Architecture and Computer Sciences. Program activities under Dr. Johnson were in the following areas: • Increase the institution’s capacity to conduct scientific research and technical investigations at the cutting-edge. • Promote interactions, collaborations and partnerships between the private sector, Federal agencies, majority research institutes and other HBCUs. • Assist other HBCUs in reaching parity in engineering and related fields. • Mentor young investigators and be a role model for students.

  16. The Business Excellence Model for CSR Implementation?

    Directory of Open Access Journals (Sweden)

    Neergaard Peter

    2014-11-01

    Full Text Available Most of the Fortune 500 companies address Corporate Social Responsibility (CSR on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating quality in organizations. CSR was first introduced in the model in 2002. From 2004 the European Foundation for Quality Management (EFQM has been eager to promote the model as an effective tool for implementing CSR.. The article discusses the potentials of the model for this end and illustrates how a 2006 European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus.

  17. Quantitative Evaluation of Local Control and Wound Healing Following Surgery and Stereotactic Spine Radiosurgery for Spine Tumors.

    Science.gov (United States)

    Harel, Ran; Emch, Todd; Chao, Samuel; Elson, Paul; Krishnaney, Ajit; Djemil, Toufik; Suh, John; Angelov, Lilyana

    2016-03-01

    The present study evaluated the optimal measuring criteria to assess spinal tumor response to surgery followed by stereotactic spine radiosurgery (SRS) and reports the local control and wound complication rates following combined multimodality treatment. Prospectively collected patient information was retrospectively reviewed to identify patients treated with spine surgery followed by SRS. Tumor sizes and volumetric assessment were formally measured. Local control status was defined according to World Health Organization (WHO, bidimensional), RECIST (unidimensional), or volumetric size change. Statistical comparative assessments of tumor measurements were performed. Twenty-two patients were eligible for evaluation after having undergone surgery followed by single-fraction SRS within a 2-month period. Seventeen had follow-up magnetic resonance imaging (MRI) with a mean patient follow-up of 12.59 months (range 3-36 months). None developed wound complication after radiation therapy (95% lower confidence bound 13%). Two patients had clinical recurrence while 15 of 17 achieved local control (88.3%). A test of marginal homogeneity for RECIST versus WHO was not statistically significant, P = 1.0 suggesting similar response classifications with both systems. Spearman correlations among 1) volumetric assessment, 2) bidimensional size, and 3) unidimensional size were significant for all groups (P spine tumor surgery delivers less radiation to the wound than conventional radiation and thus potentially reduces wound complications. Unidimensional, bidimensional, and volumetric tumor assessments demonstrate similar results. Hence the use of the simpler RECIST criteria is suitable and appropriate for evaluating the response to treatment after spine radiosurgery. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Graph Based Distributed Control for Adaptive Multi RobotPatrolling through Local Formation Transformation

    Science.gov (United States)

    2016-10-09

    In this paper, we present experiments with three real robots performing a cooperative patrolling task in multiple scenarios designed to represent...Transformation algorithm. Experiments with real robots are presented in Section IV. We draw conclusions in Section V. II. CONTROL METHODOLOGY A. Graph Theory and...achieve consensus. 1724 Fig. 4: Robots used in the experiments . The functions in Equation (11) satisfy the constraints discussed in Remark 1 and Remark 2

  19. An EXCEL macro for importing log ASCII standard (LAS) files into EXCEL worksheets

    Science.gov (United States)

    Özkaya, Sait Ismail

    1996-02-01

    An EXCEL 5.0 macro is presented for converting a LAS text file into an EXCEL worksheet. Although EXCEL has commands for importing text files and parsing text lines, LAS files must be decoded line-by-line because three different delimiters are used to separate fields of differing length. The macro is intended to eliminate manual decoding of LAS version 2.0. LAS is a floppy disk format for storage and transfer of log data as text files. LAS was proposed by the Canadian Well Logging Society. The present EXCEL macro decodes different sections of a LAS file, separates, and places the fields into different columns of an EXCEL worksheet. To import a LAS file into EXCEL without errors, the file must not contain any unrecognized symbols, and the data section must be the last section. The program does not check for the presence of mandatory sections or fields as required by LAS rules. Once a file is incorporated into EXCEL, mandatory sections and fields may be inspected visually.

  20. Basic statistics with Microsoft Excel: a review.

    Science.gov (United States)

    Divisi, Duilio; Di Leonardo, Gabriella; Zaccagna, Gino; Crisci, Roberto

    2017-06-01

    The scientific world is enriched daily with new knowledge, due to new technologies and continuous discoveries. The mathematical functions explain the statistical concepts particularly those of mean, median and mode along with those of frequency and frequency distribution associated to histograms and graphical representations, determining elaborative processes on the basis of the spreadsheet operations. The aim of the study is to highlight the mathematical basis of statistical models that regulate the operation of spreadsheets in Microsoft Excel.

  1. LICSS - a chemical spreadsheet in microsoft excel.

    Science.gov (United States)

    Lawson, Kevin R; Lawson, Jonty

    2012-02-02

    Representations of chemical datasets in spreadsheet format are important for ready data assimilation and manipulation. In addition to the normal spreadsheet facilities, chemical spreadsheets need to have visualisable chemical structures and data searchable by chemical as well as textual queries. Many such chemical spreadsheet tools are available, some operating in the familiar Microsoft Excel environment. However, within this group, the performance of Excel is often compromised, particularly in terms of the number of compounds which can usefully be stored on a sheet. LICSS is a lightweight chemical spreadsheet within Microsoft Excel for Windows. LICSS stores structures solely as Smiles strings. Chemical operations are carried out by calling Java code modules which use the CDK, JChemPaint and OPSIN libraries to provide cheminformatics functionality. Compounds in sheets or charts may be visualised (individually or en masse), and sheets may be searched by substructure or similarity. All the molecular descriptors available in CDK may be calculated for compounds (in batch or on-the-fly), and various cheminformatic operations such as fingerprint calculation, Sammon mapping, clustering and R group table creation may be carried out.We detail here the features of LICSS and how they are implemented. We also explain the design criteria, particularly in terms of potential corporate use, which led to this particular implementation. LICSS is an Excel-based chemical spreadsheet with a difference:• It can usefully be used on sheets containing hundreds of thousands of compounds; it doesn't compromise the normal performance of Microsoft Excel• It is designed to be installed and run in environments in which users do not have admin privileges; installation involves merely file copying, and sharing of LICSS sheets invokes automatic installation• It is free and extensibleLICSS is open source software and we hope sufficient detail is provided here to enable developers to add their

  2. Independent School Libraries Perspectives on excellence

    CERN Document Server

    HAND, DORCAS

    2010-01-01

    Independent School Libraries: Perspectives on Excellence offers readers insights into best practices in library services for school communities, using examples drawn from independent schools of various sizes, descriptions, and locations across the United States. Two overview essays introduce a statistical analysis of independent schools. Each of the remaining essays provides perspective on a different aspect of library practice, including staffing, advocacy, assessment, technology, collaboration, programs beyond the curriculum, intellectual freedom and privacy, budgeting, accreditation, disast

  3. Living excellence: life after Magnet designation.

    Science.gov (United States)

    Malloch, Kathy

    2009-01-01

    The achievement of Magnet recognition is the beginning of a new way of being as an organization. Strategies to support innovation leadership, value-based decision making, agility, sustainability of excellence, technology advancements, and lifelong learning are discussed within the framework of the Magnet organization. Behaviors and challenges of living the expectations of the Magnet organization are presented as opportunities to assist healthcare leaders in this important work.

  4. Forecasting with Excel: Suggestions for Managers

    Directory of Open Access Journals (Sweden)

    Scott Nadler

    2007-05-01

    Full Text Available This article provides readers and more especially business managers with an overview of moving average, exponential smoothing, trend analysis, and linear regression approaches to forecasting. The authors then provide specific examples for each approach and the Excel formulas necessary to develop effective forecasts. This is an important contribution to the literature because it demonstrates that businesses with limited resources can develop reliable and accurate forecasts in a timely and cost effective manner using readily available software.

  5. Inflammation mobilizes local resources to control hyperalgesia: the role of endogenous opioid peptides.

    Science.gov (United States)

    Alves, Daniela P; da Motta, Patrícia G; Lima, Patrícia P; Queiroz-Junior, Celso M; Caliari, Marcelo V; Pacheco, Daniela F; Pacheco, Cinthia F; Francischi, Janetti N; Duarte, Igor D G

    2012-01-01

    The aim of the present study was to investigate the mechanisms underlying the endogenous control of nociception at a peripheral level during inflammation. Using a pharmacological approach and the rat paw pressure test, we assessed the effect of an intraplantar injection of naloxone, an opioid receptor antagonist, and bestatin, an aminopeptidase inhibitor, on hyperalgesia induced by carrageenan, which mimics an inflammatory process, or prostaglandin E(2) (PGE(2)), which directly sensitizes nociceptors. Naloxone induced a significant and dose-dependent (25, 50 or 100 μg) increase in carrageenan-induced hyperalgesia, but not PGE(2)-induced hyperalgesia. Bestatin (400 μg/paw) significantly counteracted carrageenan-induced hyperalgesia, inducing an increase in the nociceptive threshold compared to control, but it did not modify hyperalgesia induced by PGE(2) injection into the rat paw. Positive β-endorphin immunoreactivity was increased in paw inflammation induced by carrageenan in comparison with the control group. However, PGE(2) did not significantly alter the immunostained area. These results provide evidence for activation of the endogenous opioidergic system during inflammation and indicate that this system regulates hyperalgesia through a negative feedback mechanism, modulating it at a peripheral level. Copyright © 2012 S. Karger AG, Basel.

  6. Stereotactic body radiation therapy for melanoma and renal cell carcinoma: impact of single fraction equivalent dose on local control

    Directory of Open Access Journals (Sweden)

    Robinson William

    2011-04-01

    Full Text Available Abstract Background Melanoma and renal cell carcinoma (RCC are traditionally considered less radioresponsive than other histologies. Whereas stereotactic body radiation therapy (SBRT involves radiation dose intensification via escalation, we hypothesize SBRT might result in similar high local control rates as previously published on metastases of varying histologies. Methods The records of patients with metastatic melanoma (n = 17 patients, 28 lesions or RCC (n = 13 patients, 25 lesions treated with SBRT were reviewed. Local control (LC was defined pathologically by negative biopsy or radiographically by lack of tumor enlargement on CT or stable/declining standardized uptake value (SUV on PET scan. The SBRT dose regimen was converted to the single fraction equivalent dose (SFED to characterize the dose-control relationship using a logistic tumor control probability (TCP model. Additionally, the kinetics of decline in maximum SUV (SUVmax were analyzed. Results The SBRT regimen was 40-50 Gy/5 fractions (n = 23 or 42-60 Gy/3 fractions (n = 30 delivered to lung (n = 39, liver (n = 11 and bone (n = 3 metastases. Median follow-up for patients alive at the time of analysis was 28.0 months (range, 4-68. The actuarial LC was 88% at 18 months. On univariate analysis, higher dose per fraction (p max was 7.9 and declined with an estimated half-life of 3.8 months to a post-treatment plateau of approximately 3. Conclusions An aggressive SBRT regimen with SFED ≥ 45 Gy is effective for controlling metastatic melanoma and RCC. The SFED metric appeared to be as robust as the BED in characterizing dose-response, though additional studies are needed. The LC rates achieved are comparable to those obtained with SBRT for other histologies, suggesting a dominant mechanism of in vivo tumor ablation that overrides intrinsic differences in cellular radiosensitivity between histologic subtypes.

  7. Effectiveness of Extracorporeal Shock Wave Therapy Without Local Anesthesia in Patients With Recalcitrant Plantar Fasciitis: A Meta-Analysis of Randomized Controlled Trials.

    Science.gov (United States)

    Lou, Jing; Wang, Shuai; Liu, Shuitao; Xing, Gengyan

    2017-08-01

    The objective of this meta-analysis was to investigate the efficacy of extracorporeal shock wave therapy in the treatment of recalcitrant plantar fasciitis without local anesthesia. The Cochrane Library, EMBASE, PubMed, and Web of Science databases were searched from inception to September 2015 for randomized controlled trials comparing ESWT without local anesthesia versus placebo for treatment of plantar fasciitis in adults. The primary outcome was the 12-week post-intervention success rate of reducing the visual analog scale score by 60% from baseline at the first step in the morning, reducing the VAS score by 60% from baseline during daily activities, reducing the Roles and Maudsley score, reducing overall heel pain, and reducing pain after applying a force meter. Nine studies were included in the meta-analysis. Compared with placebo, ESWT significantly improved the success rate of reducing overall heel pain, reducing the VAS score by 60% at the first step in the morning and during daily activities, improving the Roles and Maudsley score to excellent or good, and reducing heel pain after application of a pressure meter. ESWT seems to be particularly effective in relieving pain associated with RPF. ESWT should be considered when traditional treatments have failed. Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME OBJECTIVES: Upon completion of this article, the reader should be able to (1) understand the recovery rates for nonsurgical treatment of plantar fasciitis, (2) understand the role of extracorporeal shockwave therapy (ESWT) in the treatment of recalcitrant plantar fasciitis, and (3) understand the indications to incorporate ESWT in the treatment plan of recalcitrant plantar fasciitis. Advanced ACCREDITATION: The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.The Association of

  8. Ear Acupuncture versus  local anaestethic for pain relief during perineal repair - a randomised controlled trial

    DEFF Research Database (Denmark)

    Kindberg, Sara

    2007-01-01

    ACUPUNCTURE OR LOCAL ANAESTETICS FOR PAIN RELIEF DURING PERINEAL REPAIR AFTER VAGINAL DELIVERY: A RANDOMISED CONTROLLED TRIAL.   By:  Sara Kindberg. Midwife and PhD student, Sønderborg Hospital, Denmark. Objective: To evaluate acupuncture as a new method of pain relief for postpartum perineal...... as photos of the acupuncture points. Perspectives:  Basic midwifery services such as providing sufficient pain relief during perineal repair still need improvement. Clinical practice should be improved continuously and thus produce reliable evidence on different pain relief methods. Website:        http...

  9. Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization.

    Science.gov (United States)

    Kim, Jung; Bilder, David; Neufeld, Thomas P

    2018-01-15

    Insulin resistance, the failure to activate insulin signaling in the presence of ligand, leads to metabolic diseases, including type 2 diabetes. Physical activity and mechanical stress have been shown to protect against insulin resistance, but the molecular mechanisms remain unclear. Here, we address this relationship in the Drosophila larval fat body, an insulin-sensitive organ analogous to vertebrate adipose tissue and livers. We found that insulin signaling in Drosophila fat body cells is abolished in the absence of physical activity and mechanical stress even when excess insulin is present. Physical movement is required for insulin sensitivity in both intact larvae and fat bodies cultured ex vivo. Interestingly, the insulin receptor and other downstream components are recruited to the plasma membrane in response to mechanical stress, and this membrane localization is rapidly lost upon disruption of larval or tissue movement. Sensing of mechanical stimuli is mediated in part by integrins, whose activation is necessary and sufficient for mechanical stress-dependent insulin signaling. Insulin resistance develops naturally during the transition from the active larval stage to the immotile pupal stage, suggesting that regulation of insulin sensitivity by mechanical stress may help coordinate developmental programming with metabolism. © 2018 Kim et al.; Published by Cold Spring Harbor Laboratory Press.

  10. Using human extra-cortical local field potentials to control a switch

    Science.gov (United States)

    Kennedy, Philip; Andreasen, Dinal; Ehirim, Princewill; King, Brandon; Kirby, Todd; Mao, Hui; Moore, Melody

    2004-06-01

    Individuals with profound paralysis and mutism require a communication channel. Traditional assistive technology devices eventually fail, especially in the case of amyotrophic lateral sclerosis (ALS) subjects who gradually become totally locked-in. A direct brain-to-computer interface that provides switch functions can provide a direct communication channel to the external world. Electroencephalographic (EEG) signals recorded from scalp electrodes are significantly degraded due to skull and scalp attenuation and ambient noise. The present system using conductive skull screws allows more reliable access to cortical local field potentials (LFPs) without entering the brain itself. We describe an almost locked-in human subject with ALS who activated a switch using online time domain detection techniques. Frequency domain analysis of his LFP activity demonstrates this to be an alternative method of detecting switch activation intentions. With this brain communicator system it is reasonable to expect that locked-in, but cognitively intact, humans will always be able to communicate. Financial disclosure. Authors PK and DA may derive some financial gain from the sale of this device. A patent has been applied under US and international law: 10/675,703.

  11. Control of high-Z PFC erosion by local gas injection in DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Rudakov, D.L., E-mail: rudakov@fusion.gat.com [University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0417 (United States); Stangeby, P.C. [University of Toronto Institute for Aerospace Studies, Toronto M3H 5T6 (Canada); Wong, C.P.C. [General Atomics, P. O. Box 85608, San Diego, CA 92186-5608 (United States); McLean, A.G. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550 (United States); Wampler, W.R. [Sandia National Laboratory, P.O. Box 5800, Albuquerque, NM 87185 (United States); Watkins, J.G. [Sandia National Laboratory, P.O. Box 969, Livermore, CA 94551-0969 (United States); Boedo, J.A. [University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0417 (United States); Briesemeister, A. [Oak Ridge National Laboratory, Oak Ridge, TN 37830 (United States); Buchenauer, D.A. [Sandia National Laboratory, P.O. Box 969, Livermore, CA 94551-0969 (United States); Chrobak, C.P. [General Atomics, P. O. Box 85608, San Diego, CA 92186-5608 (United States); Elder, J.D. [University of Toronto Institute for Aerospace Studies, Toronto M3H 5T6 (Canada); Fenstermacher, M.E. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550 (United States); Guo, H.Y. [General Atomics, P. O. Box 85608, San Diego, CA 92186-5608 (United States); Lasnier, C.J. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550 (United States); Leonard, A.W. [General Atomics, P. O. Box 85608, San Diego, CA 92186-5608 (United States); Maingi, R. [Princeton Plasma Physics Laboratory, PO Box 451, Princeton, NJ 08543 (United States); Moyer, R.A. [University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0417 (United States)

    2015-08-15

    Reduced erosion of a high-Z PFC divertor surface was observed in DIII-D with local injection of methane and deuterium gases. Molybdenum-coated silicon samples were exposed in the lower divertor of DIII-D using DiMES under plasma conditions previously shown to cause significant net erosion of Mo. Three exposures with {sup 13}CH{sub 4} and one exposure with D{sub 2} gas injection about 12 cm upstream of the samples located within 1–2 cm of the attached strike point were performed. Reduction of Mo erosion was evidenced in-situ by the suppression of MoI line radiation at 386.4 nm once the gas injection started. Post-mortem ion beam analysis demonstrated that the net erosion of molybdenum near the center of the samples exposed with {sup 13}CH{sub 4} injection was below the measurement resolution of 0.5 nm, corresponding to a rate of ⩽0.04 nm/s. Compared to the previously measured erosion rates, this constitutes a reduction by a factor of >10.

  12. Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics.

    Science.gov (United States)

    Chandrawati, Rona; Olesen, Morten T J; Marini, Thatiane C C; Bisra, Gurpal; Guex, Anne Géraldine; de Oliveira, Marcelo G; Zelikin, Alexander N; Stevens, Molly M

    2017-09-01

    Enzyme prodrug therapy (EPT) enables localized conversion of inert prodrugs to active drugs by enzymes. Performance of EPT necessitates that the enzyme remains active throughout the time frame of the envisioned therapeutic application. β-glucuronidase is an enzyme with historically validated performance in EPT, however it retains its activity in biomaterials for an insufficiently long period of time, typically not exceeding 7 d. Herein, the encapsulation of β-glucuronidase in liposomal subcompartments within poly(vinyl alcohol) electrospun fibers is reported, leading to the assembly of biocatalytically active materials with activity of the enzyme sustained over at least seven weeks. It is further shown that liposomes provide the highly beneficial stabilization of the enzyme when incubated in cell culture media. The assembled biocatalytic materials successfully produce antiproliferative drugs (SN-38) using externally administered prodrugs (SN-38-glucuronide) and effectively suppress cell proliferation, with envisioned utility in the design of cardiovascular grafts. © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Synthesis and structure of a ferric complex of 2,6-di(1H-pyrazol-3-yl)pyridine and its excellent performance in the redox-controlled living ring-opening polymerization of ε-caprolactone.

    Science.gov (United States)

    Fang, Yang-Yang; Gong, Wei-Jie; Shang, Xiu-Juan; Li, Hong-Xi; Gao, Jun; Lang, Jian-Ping

    2014-06-14

    The reaction of FeCl3 with a pincer ligand, 2,6-di(1H-pyrazol-3-yl)pyridine (bppyH2), produced a mononuclear Fe(III) complex [Fe(bppyH2)Cl3] (1), which could be reduced to the corresponding Fe(II) dichloride complex [Fe(bppyH2)Cl2] (2) by suitable reducing agents such as Cp2Co or Fe powder. 1 and 2 exhibited a reversible transformation from each other with appropriate redox reagents. 1 could be utilized as a pre-catalyst to initiate the ring-opening polymerization of ε-caprolactone in the presence of alcohol but did not work. The 1/alcohol system displayed characteristics of a well-controlled polymerization with the resulting poly(ε-caprolactone) having low molecular weight distributions, a linear tendency of molecular weight evolution with conversion, and polymer growth observed for the sequential additions of ε-caprolactone monomer to the polymerization reaction. The polymerization was completely turned off by the in situ reduction of the catalytic Fe center via Cp2Co and then turned back upon the addition of [Cp2Fe]PF6. The rate of polymerization was modified by switching in situ between the Fe(III) and Fe(II) species.

  14. Control of biaxial strain in single-layer Molybdenite using local thermal expansion of the substrate

    OpenAIRE

    Plechinger, G.; Castellanos-Gomez, A.; Buscema, M.; van der Zant, H. S. J.; Steele, G. A.; Kuc, A.; Heine, T; Schüller, C.; Korn, T.

    2015-01-01

    Single-layer MoS2 is a direct-gap semiconductor whose electronic band structure strongly depends on the strain applied to its crystal lattice. While uniaxial strain can be easily applied in a controlled way, e.g., by bending of a flexible substrate with the atomically thin MoS2 layer on top, experimental realization of biaxial strain is more challenging. Here, we exploit the large mismatch between the thermal expansion coefficients of MoS2 and a silicone-based substrate to apply a controllabl...

  15. Addressing Climate Change at the State and Local Level: Using Land Use Controls to Reduce Automobile Emissions

    Directory of Open Access Journals (Sweden)

    Rachel Medina

    2010-06-01

    Full Text Available Automobiles are a major source of CO2 emissions. Because there is no immediate technological fix to reduce these emissions, the most promising current strategy is to promote less automobile use. In the United States, this is difficult because federal programs such as the interstate highway system and local land use planning and regulation have encouraged suburban sprawl. In 2006, the state of California passed legislation to roll back greenhouse emissions to 1990 levels by 2020. This legislation did not link the roll back target with land use policies. However, NGOs and the state Attorney General used the state’s pre-existing environmental impact assessment act to sue a large county east of Los Angeles alleging that its revised land use plan was inconsistent with the 2006 legislation. The state and the county settled the suit after the county agreed to new greenhouse gas mitigation duties, and in 2008 California passed additional legislation to implement its 2006 statute. Communities are strongly encouraged to adopt compact, transit-oriented development strategies to limit automobile use. The new legislation gives the attorney general and NGOs additional legal authority to challenge local land use plans and regulatory decisions which fail to adopt these strategies. California’s important experiment has lessons for all urban areas struggling to reduce automobile CO2 emissions. It suggests that local land use controls can be added to the list of workable greenhouse gas mitigation strategies.

  16. Fatigue strength of Al7075 notched plates based on the local SED averaged over a control volume

    Science.gov (United States)

    Berto, Filippo; Lazzarin, Paolo

    2014-01-01

    When pointed V-notches weaken structural components, local stresses are singular and their intensities are expressed in terms of the notch stress intensity factors (NSIFs). These parameters have been widely used for fatigue assessments of welded structures under high cycle fatigue and sharp notches in plates made of brittle materials subjected to static loading. Fine meshes are required to capture the asymptotic stress distributions ahead of the notch tip and evaluate the relevant NSIFs. On the other hand, when the aim is to determine the local Strain Energy Density (SED) averaged in a control volume embracing the point of stress singularity, refined meshes are, not at all, necessary. The SED can be evaluated from nodal displacements and regular coarse meshes provide accurate values for the averaged local SED. In the present contribution, the link between the SED and the NSIFs is discussed by considering some typical welded joints and sharp V-notches. The procedure based on the SED has been also proofed to be useful for determining theoretical stress concentration factors of blunt notches and holes. In the second part of this work an application of the strain energy density to the fatigue assessment of Al7075 notched plates is presented. The experimental data are taken from the recent literature and refer to notched specimens subjected to different shot peening treatments aimed to increase the notch fatigue strength with respect to the parent material.

  17. A controlled and sustained local gentamicin delivery system for inner ear applications.

    Science.gov (United States)

    Xu, Lei; Heldrich, Jonna; Wang, Haibo; Yamashita, Taku; Miyamoto, Shunsuke; Li, Andrew; Uboh, Cornelius E; You, Youwen; Bigelow, Douglas; Ruckenstein, Michael; O'Malley, Bert; Li, Daqing

    2010-09-01

    Intratympanic gentamicin injection (ITGI) has gained acceptance worldwide for the treatment of Ménière's disease. Reports assessing the efficacy of ITGI suffer from high variability between patients. This variability may be due to ITGI, which does not permit a sustained diffusion of gentamicin across the round window membrane. The present study investigates the effectiveness of a sustained local hydrogel system on the delivery of gentamicin into the inner ear for the treatment of Ménière's disease. A matrix of hydrogel loaded with/without gentamicin was explored in vivo. Gentamicin was applied to the ear of mice either through ITGI or in the hydrogel system. Pharmacokinetics, hearing, and balance function were examined to study how the hydrogel system affected the gentamicin delivery and inner ear functions. The 2 gentamicin delivery methods yielded different kinetics curves. The hydrogel system achieved sustained release during a 7-day period, with a flat plateau phase from Day 1 to Day 3 and slow descent in the subsequent days. The ITGI curve dramatically declined after the peak concentration at Day 1 and was almost eliminated by Day 3. The hydrogel system yielded noticeable balance dysfunction with no significant hearing changes. In contrast, ITGI exhibited no significant influences on the inner ear functions after applying the same dose of 40 kg of gentamicin. The hydrogel system established in this research allows for more sustained and consistent and efficient drug release than traditional ITGI for the transport of gentamicin into the inner ear, offering a new and exciting treatment of Ménière's disease.

  18. Control of biaxial strain in single-layer molybdenite using local thermal expansion of the substrate

    Science.gov (United States)

    Plechinger, Gerd; Castellanos-Gomez, Andres; Buscema, Michele; van der Zant, Herre S. J.; Steele, Gary A.; Kuc, Agnieszka; Heine, Thomas; Schüller, Christian; Korn, Tobias

    2015-03-01

    Single-layer MoS2 is a direct-gap semiconductor whose electronic band structure strongly depends on the strain applied to its crystal lattice. While uniaxial strain can be easily applied in a controlled way, e.g., by bending of a flexible substrate with the atomically thin MoS2 layer on top, experimental realization of biaxial strain is more challenging. Here, we exploit the large mismatch between the thermal expansion coefficients of MoS2 and a silicone-based substrate to apply a controllable biaxial tensile strain by heating the substrate with a focused laser. The effect of this biaxial strain is directly observable in optical spectroscopy as a redshift of the MoS2 photoluminescence. We also demonstrate the potential of this method to engineer more complex strain patterns by employing highly absorptive features on the substrate to achieve non-uniform heat profiles. By comparison of the observed redshift to strain-dependent band structure calculations, we estimate the biaxial strain applied by the silicone-based substrate to be up to 0.2%, corresponding to a band gap modulation of 105 meV per percentage of biaxial tensile strain.

  19. Depressive rumination and the emotional control circuit: An EEG localization and effective connectivity study.

    Science.gov (United States)

    Ferdek, Magdalena A; van Rijn, Clementina M; Wyczesany, Miroslaw

    2016-12-01

    Ruminations are repetitive thoughts associated with symptoms, causes, and consequences of one's negative feelings. The objective of this study was to explore the neuronal basis of depressive rumination in a non-clinical population within the context of emotional control. Participants scoring high or low on the tendency to ruminate scale took part in the EEG experiment. Their EEG data were collected during a state of induced depressive ruminations and compared with positive and neutral conditions. We hypothesized that both groups would differ according to the level of activation and effective connectivity among the structures involved in the emotional control circuit. Clustering of independent components, together with effective connectivity (Directed Transfer Function), was performed using the EEG signal. The main findings involved decreased activation of the left dorsolateral prefrontal cortex (DLPFC) and increased activation of the left temporal lobe structures in the highly ruminating group. The latter result was most pronounced during the ruminative condition. Decreased information from the left DLPFC to the left temporal lobe structures was also found, leading to the conclusion that hypoactivation of the left DLPFC and its inability to modulate the activation of the left temporal lobe structures is crucial for the ruminative tendencies.

  20. Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor

    Science.gov (United States)

    Hebert-Chatelain, Etienne; Reguero, Leire; Puente, Nagore; Lutz, Beat; Chaouloff, Francis; Rossignol, Rodrigue; Piazza, Pier-Vincenzo; Benard, Giovanni; Grandes, Pedro; Marsicano, Giovanni

    2014-01-01

    Brain mitochondrial activity is centrally involved in the central control of energy balance. When studying mitochondrial functions in the brain, however, discrepant results might be obtained, depending on the experimental approaches. For instance, immunostaining experiments and biochemical isolation of organelles expose investigators to risks of false positive and/or false negative results. As an example, the functional presence of cannabinoid type 1 (CB1) receptors on brain mitochondrial membranes (mtCB1) was recently reported and rapidly challenged, claiming that the original observation was likely due to artifact results. Here, we addressed this issue by directly comparing the procedures used in the two studies. Our results show that the use of appropriate controls and quantifications allows detecting mtCB1 receptor with CB1 receptor antibodies, and that, if mitochondrial fractions are enriched and purified, CB1 receptor agonists reliably decrease respiration in brain mitochondria. These data further underline the importance of adapted experimental procedures to study brain mitochondrial functions. PMID:24944910