eFORGE : A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

NARCIS (Netherlands)

Breeze, Charles E.; Paul, Dirk S.; van Dongen, Jenny; Butcher, Lee M.; Ambrose, John C.; Barrett, James E.; Lowe, Robert; Rakyan, Vardhman K.; Iotchkova, Valentina; Frontini, Mattia; Downes, Kate; Ouwehand, Willem H.; Laperle, Jonathan; Jacques, Pierre-ETienne; Bourque, Guillaume; Bergmann, Anke K.; Siebert, Reiner; Vellenga, Edo; Saeed, Sadia; Matarese, Filomena; Martens, Joost H. A.; Stunnenberg, Hendrik G.; Teschendorff, Andrew E.; Herrero, Javier; Birney, Ewan; Dunham, Ian; Beck, Stephan

2016-01-01

Epigenome-wide association studies (EWAS) provide an alternative approach for studying human disease through consideration of non-genetic variants such as altered DNA methylation. To advance the complex interpretation of EWAS, we developed eFORGE (http://eforge.cs.ucl.ac.uk/), a new stand-alone and

Poola videokunstnik piilub kunstihoones naiste sauna / Rainer Vilumaa

Index Scriptorium Estoniae

Vilumaa, Rainer

2005-01-01

Poola meediakunstniku Katarzyna Kozyra 1997. aastast pärit ruumiinstallatsioonist "Naiste saun". See on esimene videoteos seeriast, kus kunstnik kasutab varjatud kaamerat. Näidatakse Tallinna Kunstihoones näitusel "Homo grandis natu"

In-situ growth of AuNPs on WS2@U-bent optical fiber for evanescent wave absorption sensor

Science.gov (United States)

Zhang, Suzhen; Zhao, Yuefeng; Zhang, Chao; Jiang, Shouzhen; Yang, Cheng; Xiu, Xianwu; Li, Chonghui; Li, Zhen; Zhao, Xiaofei; Man, Baoyuan

2018-05-01

The sensitivity of the evanescent wave absorption sensor is always a hot topic which has been attracted researchers' discussion. It is still a challenge for developing the effective sensor to sensitively detect some biochemical molecules solution in a simple and low-cost way. In this paper, an evanescent wave absorption (EWA) sensor has been presented based on the U-bent multimode fiber coated with tungsten disulfide (WS2) film and in-situ growth of gold nanoparticles (AuNPs) for the detection of ethanol solution and sodium chloride (NaCl) solution. Benefitted from the effective light coupling produced between U-bent probe and AuNPs, we attained the optimal size of the AuNPs by changing the reaction time between WS2 and tetrachloroauric acid (HAuCl4). With the AuNPs/WS2@U-bent optical fiber, we discussed the behaviors of EWA sensor, such as sensitivity, reproducibility, fast response-recovery time and stability. The sensitivity (△A/△C) of the proposed AuNPs/WS2@U-bent optical fiber EWA sensor is 0.65 for the detection of the ethanol solution. Besides, the AuNPs/WS2@U-bent optical fiber EWA sensor exhibits high sensitivity in detection of the sodium chloride (NaCl), which can reach 1.5 when the proposed sensor was immersed into NaCl solution. Our work demonstrates that the U-bent optical fiber EWA sensor may have promising applications in testing the solution of concentration.

Trouble in NIFLHEIM Elements of a NATO Arctic Strategy

Science.gov (United States)

2015-06-01

comparison.35 According to Robert W. Baird Equity Research North American fracking /shale oil has a break-even production cost of $53 to $93 per...extractive technologies especially hydraulic fracturing, have increased U.S. hydrocarbon production, 94 Katarzyna

Gamma camera scatter suppression unit WAM

International Nuclear Information System (INIS)

Kishi, Haruo; Shibahara, Noriyuki; Hirose, Yoshiharu; Shimonishi, Yoshihiro; Oumura, Masahiro; Ikeda, Hozumi; Hamada, Kunio; Ochi, Hironobu; Itagane, Hiroshi.

1990-01-01

In gamma camera imaging, scattered radiation is one of big factors to decrease image contrast. Simply, scatter suppression makes signal to noise ratio larger, but it makes statistics error because of radionuclide injection limit to the human body. EWA is a new method that suppresses scattered radiation and improves image contrast. In this article, WAM which is commercialized EWA method by Siemens Gammasonics Inc. is presented. (author)

African Journal of Biotechnology - Vol 12, No 40 (2013)

African Journals Online (AJOL)

Water and energy saving bioprocess for bioethanol production from corn grain applying stillage liquid part recirculation · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Małgorzata Lasik, Małgorzata Gumienna, Katarzyna Szambelan, Zbigniew Czarnecki.

Swimming Against the Current: A Qualitative Review of the Work Experiences and Adaptations made by Employees with Arthritis.

Science.gov (United States)

Purc-Stephenson, R J; Dostie, Jessica; Smith, Hailey J

2018-01-30

To describe the experiences and strategies of employees with arthritis (EwA) to maintain employment and to use this information to build a conceptual model. We conducted a systematic review of qualitative studies that examined the work experiences of EwA. Published studies on arthritis and employment were searched from electronic databases (1980-2017) and bibliographical reviews of relevant studies. We used meta-ethnography to synthesize the findings. We reviewed 17 studies reporting on the experiences of 873 employees. We identified 11 main themes that highlight common issues experienced by EwA, and grouped these into four higher-order categories: nature of the disease (emotional issues, cognitive struggles, physical symptoms), intrapersonal issues (personal meaning of work, preserving a work identity), interpersonal issues (managing disclosure, gaining co-worker support, organizational culture issues), and work-sustainability strategies (making personal adjustments, using social support, using workplace accommodations). Using these themes, we developed the Job Sustainability Model to illustrate how disease, personal, and work-related factors interact to influence what type of coping behaviors are used and when. Initially, EwA rely on making personal adjustments, using social support, and medical intervention. However, when these coping behaviors fail to be effective, they draw upon workplace accommodations and resources. Arthritis disrupts an employee's work life by impairing his or her capacity to be a productive worker. Our results highlight how EwA make strategic adaptations to maintain a productive work life for as long as possible. The findings of this study have implications for work-related interventions aimed at preserving employment. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

"Su mõte on see, mida elad" : vanadus / Kaire Nurk

Index Scriptorium Estoniae

Nurk, Kaire, 1960-

2005-01-01

Reet Varblase kuraatoriprojektist "Homo grandis natu" Tallinna Kunstihoones kuni 15. V. Tallinna Kunstikooli õpilaste (õpetaja Katrin Tukmann), Katarzyna Kozyra, Eveli Variku, Marge Monko, Piia Ruberi & Doris Kareva ja Mare Mikofi töödest, Tallinna Ülikooli audiovisuaalkunsti osakonnas tehtud filmidest (Elen Lotman, Jaak Kilmi, Kalev Hiller)

A new automatic algorithm for quantification of myocardial infarction imaged by late gadolinium enhancement cardiovascular magnetic resonance: experimental validation and comparison to expert delineations in multi-center, multi-vendor patient data.

Science.gov (United States)

Engblom, Henrik; Tufvesson, Jane; Jablonowski, Robert; Carlsson, Marcus; Aletras, Anthony H; Hoffmann, Pavel; Jacquier, Alexis; Kober, Frank; Metzler, Bernhard; Erlinge, David; Atar, Dan; Arheden, Håkan; Heiberg, Einar

2016-05-04

Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) using magnitude inversion recovery (IR) or phase sensitive inversion recovery (PSIR) has become clinical standard for assessment of myocardial infarction (MI). However, there is no clinical standard for quantification of MI even though multiple methods have been proposed. Simple thresholds have yielded varying results and advanced algorithms have only been validated in single center studies. Therefore, the aim of this study was to develop an automatic algorithm for MI quantification in IR and PSIR LGE images and to validate the new algorithm experimentally and compare it to expert delineations in multi-center, multi-vendor patient data. The new automatic algorithm, EWA (Expectation Maximization, weighted intensity, a priori information), was implemented using an intensity threshold by Expectation Maximization (EM) and a weighted summation to account for partial volume effects. The EWA algorithm was validated in-vivo against triphenyltetrazolium-chloride (TTC) staining (n = 7 pigs with paired IR and PSIR images) and against ex-vivo high resolution T1-weighted images (n = 23 IR and n = 13 PSIR images). The EWA algorithm was also compared to expert delineation in 124 patients from multi-center, multi-vendor clinical trials 2-6 days following first time ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) (n = 124 IR and n = 49 PSIR images). Infarct size by the EWA algorithm in vivo in pigs showed a bias to ex-vivo TTC of -1 ± 4%LVM (R = 0.84) in IR and -2 ± 3%LVM (R = 0.92) in PSIR images and a bias to ex-vivo T1-weighted images of 0 ± 4%LVM (R = 0.94) in IR and 0 ± 5%LVM (R = 0.79) in PSIR images. In multi-center patient studies, infarct size by the EWA algorithm showed a bias to expert delineation of -2 ± 6 %LVM (R = 0.81) in IR images (n = 124) and 0 ± 5%LVM (R = 0.89) in

Therapy of psoriasis with narrowband ultraviolet-B light influences plasma concentrations of MMP-2 and TIMP-2 in patients

Directory of Open Access Journals (Sweden)

Głażewska EK

2016-10-01

Full Text Available Edyta Katarzyna Głażewska,1 Marek Niczyporuk,1 Sławomir Ławicki,2 Maciej Szmitkowski,2 Monika Zajkowska,2 Grażyna Ewa Będkowska,3 Andrzej Przylipiak1 1Department of Esthetic Medicine, 2Department of Biochemical Diagnostics, 3Department of Haematological Diagnostics, Medical University, Białystok, Poland Background: Matrix metalloproteinases (MMPs, which show a significant ability to cleave the components of extracellular matrix, and tissue inhibitors of metalloproteinases (TIMPs, which slow down the activity of those enzymes, may be implicated in the pathogenesis and spread of psoriatic disease. This study aims to analyze plasma levels of MMP-2 and TIMP-2 in plaque psoriasis patients before and after the course of narrowband ultraviolet-B (NBUVB therapy with respect to disease advancement. Patients and methods: A total of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were enrolled into the study. Plasma levels of MMP-2 and TIMP-2 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index (PASI was used to define the disease advancement. Results: The results showed increased plasma levels of MMP-2 and TIMP-2, but this change was significant only in case of MMP-2 in total psoriatic group compared to healthy subjects. Moreover, there was an increase in the concentrations of chosen factors with an increase in the severity of the disease. The NBUVB therapy causes a decline in the concentration of the analyzed enzyme and its inhibitor, although this change was statistically significant in the total psoriatic group only in case of MMP-2. There was also a positive correlation between MMP-2, TIMP-2, and PASI score value. Conclusion: Our study highlights a possible important role of MMP-2 in the activity of psoriasis and clearance of disease symptoms. Moreover, plasma MMP-2 seems to be a valuable psoriasis biomarker. Keywords: gelatinase A, matrix metalloproteinases, tissue inhibitor of

DNA Methylation Patterns in Cord Blood of Neonates Across Gestational Age: Association With Cell-Type Proportions.

Science.gov (United States)

Braid, Susan M; Okrah, Kwame; Shetty, Amol; Corrada Bravo, Hector

A statistical methodology is available to estimate the proportion of cell types (cellular heterogeneity) in adult whole blood specimens used in epigenome-wide association studies (EWAS). However, there is no methodology to estimate the proportion of cell types in umbilical cord blood (also a heterogeneous tissue) used in EWAS. The objectives of this study were to determine whether differences in DNA methylation (DNAm) patterns in umbilical cord blood are the result of blood cell type proportion changes that typically occur across gestational age and to demonstrate the effect of cell type proportion confounding by comparing preterm infants exposed and not exposed to antenatal steroids. We obtained DNAm profiles of cord blood using the Illumina HumanMethylation27k BeadChip array for 385 neonates from the Boston Birth Cohort. We estimated cell type proportions for six cell types using the deconvolution method developed by . The cell type proportion estimates segregated into two groups that were significantly different by gestational age, indicating that gestational age was associated with cell type proportion. Among infants exposed to antenatal steroids, the number of differentially methylated CpGs dropped from 127 to 1 after controlling for cell type proportion. EWAS utilizing cord blood are confounded by cell type proportion. Careful study design including correction for cell type proportion and interpretation of results of EWAS using cord blood are critical.

Ergonomic analysis in the manual transport of loads: a case study in a cement production company

Directory of Open Access Journals (Sweden)

Jarbas Rocha Martins

2017-03-01

Full Text Available This study aims to analyze the manual transport activity of 50kg bags in a cement production company by means of ergonomic work analysis (EWA, identifying environmental factors and loaders’ working conditions. In order for EWA to take place, photographic records, videos and interviews were performed. It covered aspects related to lifting, transportation and handling of cement bags, as well as observations of loaders’ posture while performing the activity. In this sense, both qualitative and quantitative aspects were taken into account, which were evidenced by the use of instruments for determining the concentration of agents in the environment. In addition, some management tools, such as the cause and effect diagram, and interviews conducted during the field research were used. It was found that the high rate of absenteeism in the activity is related to the strict control of productivity, the excessive lifting and manual transport of weights, and repetitive trunk flexion movements. The results shown by the EWA made it possible to propose preventive measures and some changes in the work environment.

Comparison of projection skills of deterministic ensemble methods using pseudo-simulation data generated from multivariate Gaussian distribution

Science.gov (United States)

Oh, Seok-Geun; Suh, Myoung-Seok

2017-07-01

The projection skills of five ensemble methods were analyzed according to simulation skills, training period, and ensemble members, using 198 sets of pseudo-simulation data (PSD) produced by random number generation assuming the simulated temperature of regional climate models. The PSD sets were classified into 18 categories according to the relative magnitude of bias, variance ratio, and correlation coefficient, where each category had 11 sets (including 1 truth set) with 50 samples. The ensemble methods used were as follows: equal weighted averaging without bias correction (EWA_NBC), EWA with bias correction (EWA_WBC), weighted ensemble averaging based on root mean square errors and correlation (WEA_RAC), WEA based on the Taylor score (WEA_Tay), and multivariate linear regression (Mul_Reg). The projection skills of the ensemble methods improved generally as compared with the best member for each category. However, their projection skills are significantly affected by the simulation skills of the ensemble member. The weighted ensemble methods showed better projection skills than non-weighted methods, in particular, for the PSD categories having systematic biases and various correlation coefficients. The EWA_NBC showed considerably lower projection skills than the other methods, in particular, for the PSD categories with systematic biases. Although Mul_Reg showed relatively good skills, it showed strong sensitivity to the PSD categories, training periods, and number of members. On the other hand, the WEA_Tay and WEA_RAC showed relatively superior skills in both the accuracy and reliability for all the sensitivity experiments. This indicates that WEA_Tay and WEA_RAC are applicable even for simulation data with systematic biases, a short training period, and a small number of ensemble members.

Kuldlõvid Louise Bourgeois'le, Bruce Naumanile ja Itaalia paviljonile / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

1999-01-01

Veneetsia 48. rahvusvahelise kunstibiennaali preemiasaajad, premeeritud tööd, korralduskomitee ja žürii koosseis. Kuldlõvid: Louise Bourgeois, Bruce Nauman, Itaalia paviljon (Monica Bonvicini, Bruna Esposito, Luisa Lambri, Paola Pivi, Grazia Toderi ühisprojekt); kolm rahvusvahelist preemiat: Doug Aitken, Cai Gou-Qiang, Shirin Neshat; žürii tõstis esile: Georges Abeagbo, Eija-Liisa Ahtila, Katarzyna Kozura ? (Kozyra), Lee Bul; UNESCO preemia: Ghada Amer

Adverse outcomes after percutaneous dilatational tracheostomy versus surgical tracheostomy in intensive care patients: case series and literature review

OpenAIRE

Jarosz, Konrad; Kubisa, Bartosz; Andrzejewska, Agata; Mr?wczy?ska, Katarzyna; Hamerlak, Zbigniew; Bartkowska-?niatkowska, Alicja

2017-01-01

Konrad Jarosz,1 Bartosz Kubisa,2 Agata Andrzejewska,3 Katarzyna Mrówczyńska,3 Zbigniew Hamerlak,4 Alicja Bartkowska-Śniatkowska5 1Department of Clinical Nursing, Pomeranian Medical University, 2Thoracic Surgery and Transplantation Department, Pomeranian Medical University, 3Anaesthesiology and Intensive Care Department, Pomeranian Medical University, 4Stomatology Department, Pomeranian Medical University, 5Anaesthesiology and Pediatric Intensive Care Department, Poznan Universit...

International Conference on Microtechnology and Thermal Problems in Electronics (MicroTherm'2015) and International Conference on Smart Engineering of New Materials (SENM'2015)

International Nuclear Information System (INIS)

2016-01-01

. The latter gave an opportunity for students and young researchers to present their first achievements in the field of science. Next Joint Event combining MicroTherm and SENM Conferences is going to be held in June 2017, traditionally in Lodz – beautiful, post-industrial city located in the centre of Poland. For further details, please see the Duoconference web site www.semtherm.eu. Please, feel invited. Ewa Raj and Katarzyna Znajdek Editors (paper)

Effect of Nordic Walking training on iron metabolism in elderly women

Directory of Open Access Journals (Sweden)

Kortas J

2015-11-01

Full Text Available Jakub Kortas,1 Katarzyna Prusik,2 Damian Flis,3 Krzysztof Prusik,1 Ewa Ziemann,4 Neil Leaver,5 Jedrzej Antosiewicz6 1Department of Recreation and Tourism, Gdansk University of Physical Education and Sport, Gdansk, Poland; 2Department of Biomedical Basis of Health, Gdansk University of Physical Education and Sport, Gdansk, Poland; 3Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Gdansk, Poland; 4Department of Physiology and Pharmacology, Gdansk University of Physical Education and Sport, Gdansk, Poland; 5The Immunosuppression monitoring service (IMS Laboratory, Royal Brompton & Harefield NHS Foundation Trust, Heart Science Centre, Harefield Hospital, Harefield, UK; 6Department of Biochemistry, Gdansk University of Physical Education and Sport, Gdansk, Poland Background: Despite several, well-documented pro-healthy effects of regular physical training, its influence on body iron stores in elderly people remains unknown. At the same time, body iron accumulation is associated with high risk of different morbidities.Purpose: We hypothesized that Nordic Walking training would result in pro-healthy changes in an elderly group of subjects by reducing body iron stores via shifts in iron metabolism-regulating proteins.Methods: Thirty-seven women aged 67.7±5.3 years participated in this study. They underwent 32 weeks of training, 1-hour sessions three times a week, between October 2012 and May 2013. Fitness level, blood morphology, CRP, vitamin D, ferritin, hepcidin, and soluble Hjv were assessed before and after the training.Results: The training program caused a significant decrease in ferritin, which serves as a good marker of body iron stores. Simultaneously, the physical cardiorespiratory fitness had improved. Furthermore, blood hepcidin was positively correlated with the ferritin concentration after the training. The concentration of blood CRP dropped, but the change was nonsignificant. The applied training

Poolakad näitavad etlemiskunsti / Gert Hatsukov ; interv. Johannes Saar

Index Scriptorium Estoniae

Hatsukov, Gert

2004-01-01

Ürituse korraldaja Gert Hatsukoviga poola etlemiskunstnikest Pawel Kwasniewskist, Wladislav Kazmierczakist, Ewa Rybskast, Artur Grabowskist ja Dariusz Fodczukist. Poola etlemiskunsti õhtupoolik "Transmission" toimub Vaal-galeriis

A Proxy Method for Estimation of EE-index using MAGDAS/CPMN Data

Science.gov (United States)

Ueno, T.; Yumoto, K.; Uozumi, T.; Numata, Y.; Group, M.

2008-12-01

EE-index (EDst, EU, and EL) is a new index proposed by Space Environment Research Center, Kyushu University (see Uozumi et al., 2008) to monitor temporal and long-term variations of the equatorial electrojet (EEJ). EU and EL mainly represent the range of EEJ and CEJ (equatorial counter electrojet) components, respectively. The baseline levels of EU and EL are obtained by averaging the H-component magnetic variations observed at the nightside (LT = 18-06) MAGDAS/CPMN stations along the magnetic equator. EDst, defined by Uozumi et al. (2008) fluctuates depending on the number of stations in the nightside sector (LT = 18-06). If the number is few, EDst may include some local fluctuations: the partial ring current component, substorm component and so on. Such local components cause some error in estimating the baseline level of EU or EL. Therefore, we need to use as many stations' data as possible in order to derive EU and EL properly. Pacific region is one of the most difficult areas to measure the magnetic field near the dip equator, because there are few islands. In the present paper, we developed a new method to use the data obtained from Ewa Beach (EWA; G. Lat. = 21.32N, G. Long. = 158.0W, Dip Lat. = 38.03), Hawaii, USA for estimation of EDst. EWA is not the equatorial station, but its nighttime H-component magnetic variations are found to be similar to those of Christmas Island (CXI; G. Lat. = 2.05N, G. Long. = 157.5W, Dip Lat. = 5.24), Kiribati. Data from EWA can be used as a proxy of that from CXI for monitoring temporal and long-term variations of the equatorial electrojet (EEJ) in real time. Acknowledgements: Authors appreciate Prof. Hisashi Utada of Earthquake Research Institute, University of Tokyo for supplying the magnetometer data from Christmas Island, Kiribati. Our deepest gratitude goes to all the members of the MAGDAS/CPMN project for their ceaseless support. Especially, we wish to thank the staffs of the observation stations: Dr. Baylie Damtie

Lumbar paravertebral blockade as intractable pain management method in palliative care

OpenAIRE

Zaporowska-Stachowiak I; Kotlinska-Lemieszek A; Kowalski G; Kosicka K; Hoffmann K; Główka F; Łuczak J

2013-01-01

Iwona Zaporowska-Stachowiak,1,2 Aleksandra Kotlinska-Lemieszek,3 Grzegorz Kowalski,3 Katarzyna Kosicka,4 Karolina Hoffmann,5 Franciszek Główka,4 Jacek Łuczak2 1Department of Pharmacology, 2Palliative Medicine In-patient Unit, University Hospital of Lord’s Transfiguration, 3Department of Palliative Care, 4Department of Physical Pharmacy and Pharmacokinetics, 5Department of Internal Medicine, Metabolic Disorders and Arterial Hypertension, Poznan University of Medical Scie...

Barbers Point Sewage Outfall Fish Census from Annual Surveys 1991-2010 (NODC Accession 0073346)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Honouliuli Wastewater Treatment Plant (WWTP) located in Ewa, Oahu, Hawaii, near Barbers Point (Kalaeloa) has been in operation since 1982. It releases...

Probabilistic stability and "tall" wind profiles: theory and method for use in wind resource assessment

DEFF Research Database (Denmark)

Kelly, Mark C.; Troen, Ib

2016-01-01

A model has been derived for calculating the aggregate effects of stability and the finite height of the planetary boundary layer upon the long-term mean wind profile. A practical implementation of this probabilistic extended similarity-theory model is made, including its incorporation within...... to the methodology. Results of the modeling are shown for a number of sites, with discussion of the models’ efficacy and the relative improvement shown by the new model, for situations where a user lacks local heat flux information, as well as performance of the new model using measured flux statistics. Further...... the European Wind Atlas (EWA) methodology for site-to-site application. Theoretical and practical implications of the EWA methodology are also derived and described, including unprecedented documentation of the theoretical framework encompassing vertical extrapolation, as well as some improvement...

Homme kell 14 algab Vaala galeriis järjekordse "INPORTi" raames...

Index Scriptorium Estoniae

2004-01-01

Poola kunstnike Dariusz Fodczuki (sünd. 1966), Wladislaw Kazmierczaki (sünd. 1951), Ewa Rybska (sünd. 1958), Artur Grabowski ja Pawel Kwasniewski (sünd. 1963) performance'ite esitlus. Korraldaja Gert Hatsukov

Bydgoszcz universities students' awareness about melanoma

OpenAIRE

Mirończuk, Katarzyna; Kałużna, Lucyna; Łakomski, Mateusz; Zukow, Walery

2017-01-01

Mirończuk Katarzyna, Kałużna Lucyna, Łakomski Mateusz, Zukow Walery. Bydgoszcz universities students' awareness about melanoma. Journal of Education, Health and Sport. 2017;7(8):566-575. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.887380 http://ojs.ukw.edu.pl/index.php/johs/article/view/4784 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Edu...

Etiologia i patomechanizm uszkodzenia ścięgna Achillesa = The etiology and patomechanizm damage to the Achilles tendon

OpenAIRE

Strojek, Katarzyna; Piekorz, Zuzanna; Kaźmierczak, Urszula; Strączyńska, Agnieszka; Zukow, Walery

2016-01-01

Strojek Katarzyna, Piekorz Zuzanna, Kaźmierczak Urszula, Strączyńska Agnieszka, Zukow Walery. Etiologia i patomechanizm uszkodzenia ścięgna Achillesa = The etiology and patomechanizm damage to the Achilles tendon. Journal of Education, Health and Sport. 2016;6(11):147-160. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.164687 http://ojs.ukw.edu.pl/index.php/johs/article/view/3976 https://pbn.nauka.gov.pl/sedno-webapp/works/755729 The journal has had 7 poin...

Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literatury = Sterile necrosis of bone, the characteristics of the illness and physical examination - a literature review

OpenAIRE

Radzimińska, Agnieszka; Zimmermann, Agnieszka Anna; Weber-Rajek, Magdalena; Strojek, Katarzyna; Bułatowicz, Irena; Goch, Aleksander; Zukow, Walery

2015-01-01

Radzimińska Agnieszka, Zimmermann Agnieszka Anna, Weber-Rajek Magdalena, Strojek Katarzyna, Bułatowicz Irena, Goch Aleksander, Zukow Walery. Jałowe martwice kości, charakterystyka choroby i postępowanie fizykalne – przegląd literatury = Sterile necrosis of bone, the characteristics of the illness and physical examination - a literature review. Journal of Education, Health and Sport. 2015;5(10):108-120. ISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.32518 http://ojs.ukw.edu.pl/index....

EWAS: Modeling Application for Early Detection of Terrorist Threats

Science.gov (United States)

Qureshi, Pir Abdul Rasool; Memon, Nasrullah; Wiil, Uffe Kock

This paper presents a model and system architecture for an early warning system to detect terrorist threats. The paper discusses the shortcomings of state-of-the-art systems and outlines the functional requirements that must to be met by an ideal system working in the counterterrorism domain. The concept of generation of early warnings to predict terrorist threats is presented. The model relies on data collection from open data sources, information retrieval, information extraction for preparing structured workable data sets from available unstructured data, and finally detailed investigation. The conducted investigation includes social network analysis, investigative data mining, and heuristic rules for the study of complex covert networks for terrorist threat indication. The presented model and system architecture can be used as a core framework for an early warning system.

Jllumina - A comprehensive Java-based API for statistical Illumina Infinium HumanMethylation450 and Infinium MethylationEPIC BeadChip data processing

Directory of Open Access Journals (Sweden)

Almeida Diogo

2016-10-01

Full Text Available Measuring differential methylation of the DNA is the nowadays most common approach to linking epigenetic modifications to diseases (called epigenome-wide association studies, EWAS. For its low cost, its efficiency and easy handling, the Illumina HumanMethylation450 BeadChip and its successor, the Infinium MethylationEPIC BeadChip, is the by far most popular techniques for conduction EWAS in large patient cohorts. Despite the popularity of this chip technology, raw data processing and statistical analysis of the array data remains far from trivial and still lacks dedicated software libraries enabling high quality and statistically sound downstream analyses. As of yet, only R-based solutions are freely available for low-level processing of the Illumina chip data. However, the lack of alternative libraries poses a hurdle for the development of new bioinformatic tools, in particular when it comes to web services or applications where run time and memory consumption matter, or EWAS data analysis is an integrative part of a bigger framework or data analysis pipeline. We have therefore developed and implemented Jllumina, an open-source Java library for raw data manipulation of Illumina Infinium HumanMethylation450 and Infinium MethylationEPIC BeadChip data, supporting the developer with Java functions covering reading and preprocessing the raw data, down to statistical assessment, permutation tests, and identification of differentially methylated loci. Jllumina is fully parallelizable and publicly available at http://dimmer.compbio.sdu.dk/download.html

Bezpieczne formy aktywności fizycznej dla kobiet w ciąży = Secure forms of physical activity for pregnant women

OpenAIRE

Urtnowska, Katarzyna; Bułatowicz, Irena; Ludwikowski, Grzegorz; Zukow, Walery

2016-01-01

Urtnowska Katarzyna, Bułatowicz Irena, Ludwikowski Grzegorz, Zukow Walery. Bezpieczne formy aktywności fizycznej dla kobiet w ciąży = Secure forms of physical activity for pregnant women. Journal of Education, Health and Sport. 2016;6(5):291-297. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.51894 http://ojs.ukw.edu.pl/index.php/johs/article/view/3526 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23...

Stosowanie zabiegów fizjoterapeutycznych u osób uprawiających balet po urazie sportowym oraz przeciążeniach narządu ruchu = The use of physical therapy in people practicing ballet trauma and sports overload the musculoskeletal system

OpenAIRE

Michalczak, Magdalena; Bojarczuk, Katarzyna; Smoleń, Agata

2016-01-01

Michalczak Magdalena, Bojarczuk Katarzyna, Smoleń Agata. Stosowanie zabiegów fizjoterapeutycznych u osób uprawiających balet po urazie sportowym oraz przeciążeniach narządu ruchu = The use of physical therapy in people practicing ballet trauma and sports overload the musculoskeletal system. Journal of Education, Health and Sport. 2016;6(7):640-651. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.60867 http://ojs.ukw.edu.pl/index.php/johs/article/view/3783 The j...

Biomarkers of exposure in environment-wide association studies - Opportunities to decode the exposome using human biomonitoring data.

Science.gov (United States)

Steckling, Nadine; Gotti, Alberto; Bose-O'Reilly, Stephan; Chapizanis, Dimitris; Costopoulou, Danae; De Vocht, Frank; Garí, Mercè; Grimalt, Joan O; Heath, Ester; Hiscock, Rosemary; Jagodic, Marta; Karakitsios, Spyros P; Kedikoglou, Kleopatra; Kosjek, Tina; Leondiadis, Leondios; Maggos, Thomas; Mazej, Darja; Polańska, Kinga; Povey, Andrew; Rovira, Joaquim; Schoierer, Julia; Schuhmacher, Marta; Špirić, Zdravko; Stajnko, Anja; Stierum, Rob; Tratnik, Janja Snoj; Vassiliadou, Irene; Annesi-Maesano, Isabella; Horvat, Milena; Sarigiannis, Dimosthenis A

2018-07-01

The European Union's 7th Framework Programme (EU's FP7) project HEALS - Health and Environment-wide Associations based on Large Population Surveys - aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited. The objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS). In a face-to-face group discussion, scope, content, and structure of the HEALS deliverable "Guidelines for appropriate BoE selection for EWAS studies" were determined. An expert-driven, distributed, narrative review process involving around 30 individuals of the HEALS consortium made it possible to include extensive information targeted towards the specific characteristics of various environmental stressors and exposure determinants. From the resulting 265 page report, targeted information about BoE, corresponding reference values (e.g., 95th percentile or measures of central tendency), exposure limit values (e.g., the German HBM I and II values) and biomonitoring equivalents (BEs) were summarized and updated. 64 individual biological, chemical, physical, psychological and social environmental stressors or exposure determinants were included to fulfil the requirements of EWAS. The list of available BoEs is extensive with a number of 135; however, 12 of the stressors and exposure determinants considered do not leave any measurable specific substance in accessible body specimens. Opportunities to estimate the internal exposure stressors not (yet) detectable in human specimens were discussed. Data about internal exposures are useful to decode

On the potential of models for location and scale for genome-wide DNA methylation data.

Science.gov (United States)

Wahl, Simone; Fenske, Nora; Zeilinger, Sonja; Suhre, Karsten; Gieger, Christian; Waldenberger, Melanie; Grallert, Harald; Schmid, Matthias

2014-07-03

With the help of epigenome-wide association studies (EWAS), increasing knowledge on the role of epigenetic mechanisms such as DNA methylation in disease processes is obtained. In addition, EWAS aid the understanding of behavioral and environmental effects on DNA methylation. In terms of statistical analysis, specific challenges arise from the characteristics of methylation data. First, methylation β-values represent proportions with skewed and heteroscedastic distributions. Thus, traditional modeling strategies assuming a normally distributed response might not be appropriate. Second, recent evidence suggests that not only mean differences but also variability in site-specific DNA methylation associates with diseases, including cancer. The purpose of this study was to compare different modeling strategies for methylation data in terms of model performance and performance of downstream hypothesis tests. Specifically, we used the generalized additive models for location, scale and shape (GAMLSS) framework to compare beta regression with Gaussian regression on raw, binary logit and arcsine square root transformed methylation data, with and without modeling a covariate effect on the scale parameter. Using simulated and real data from a large population-based study and an independent sample of cancer patients and healthy controls, we show that beta regression does not outperform competing strategies in terms of model performance. In addition, Gaussian models for location and scale showed an improved performance as compared to models for location only. The best performance was observed for the Gaussian model on binary logit transformed β-values, referred to as M-values. Our results further suggest that models for location and scale are specifically sensitive towards violations of the distribution assumption and towards outliers in the methylation data. Therefore, a resampling procedure is proposed as a mode of inference and shown to diminish type I error rate in

An epigenome-wide study of obesity in African American youth and young adults : novel findings, replication in neutrophils, and relationship with gene expression

NARCIS (Netherlands)

Wang, Xiaoling; Pan, Yue; Zhu, Haidong; Hao, Guang; Huang, Yisong; Barnes, Vernon; Shi, Huidong; Snieder, Harold; Pankow, James; North, Kari; Grove, Megan; Guan, Weihua; Demerath, Ellen; Dong, Yanbin; Su, Shaoyong

2018-01-01

Background: We conducted an epigenome-wide association study (EWAS) on obesity in healthy youth and young adults and further examined to what extent identified signals influenced gene expression and were independent of cell type composition and obesity-related cardio-metabolic risk factors.

Poolakad eesti kunsti omaruumis / Riin Kübarsepp

Index Scriptorium Estoniae

Kübarsepp, Riin, 1978-

2004-01-01

Vaal-galeriis 29. V toimunud poola tegevuskunsti pärastlõunast "Tramsmission" ja osalenud kunstnikest (Dariusz Fodczuki, Wladislaw Kazmierczak, Ewa Rybska, Pawel Kwasniewski). Tähenduslikuna mõjus galeriis väljas olnud Jüri Ojaveri ruumiinstallatsioon "...töökas ning leidlik"

Ergonomic work analysis: A case study of bus drivers in the private collective transportation sector.

Science.gov (United States)

Araújo, Adolfo Vicente; Arcanjo, Gemima Santos; Fernandes, Haroldo; Arcanjo, Georgia Santos

2018-05-03

The collective transportation system is essential to reduce the number of automobiles in the roads. Concerns exist related to quality, comfort and safety of bus driver's workstations. The objective of this study was to improve the driver's workstation in the private collective transportation sector by analyzing ergonomic practices using the Ergonomic Work Analysis (EWA). The EWA was chosen because it seeks to evaluate the labor condition as it relates to the psychophysiological conditions of workers, it complies with regulatory standard 17 (NR17). To identify driver concerns, interviews and questionnaires were administered. The workstation and worker routines were observed. The analysis revealed that the largest number of complaints related to noise, display light and location of the passenger identifier device. Drivers reported discomfort in the knees and lower back. Recommendations were made to improve the workstation and change the routine to minimize the discomfort and ergonomic risk factors.

Effect of Nuclear Reactions on the Properties of Al-Mg-Si Alloys after Long-Time Exploitation in Research Reactors

CERN Document Server

Hofmann, A; Szteke, W; Hajewska, E; Wagner, T; Semina, V K

2004-01-01

Effect of fast neutron ($E>$ 0.1~?eV) irradiation on the mechanical properties and fracture morphology of the Al-Mg-Si alloys (PAR-1 and ???-1) after 40 years of exploitation in research nuclear reactors has been studied. Tested specimens were cut from structural elements of reactor EWA ($\\acute{\\rm S}$wierk, Poland). Irradiation induces degradation in mechanical properties, namely yield strength and ultimate strength increase, but elongation reduces. The mechanical property changes are caused by ageing of Al--Mg--Si alloy. During irradiation Si is formed from Al by the Al($n, \\gamma $)Si reaction. The presence of Si might cause strengthening of the Al--Mg--Si alloys by increasing precipitation of Mg$_{2}$Si or pure Si in the Al matrix. Post-irradiation activity studies of EWA reactor structural elements show that the high-activity $^{60}$Co and $^{65}$Zn isotopes have been formed by the nuclear reactions.

Effect of nuclear reactions on the properties of Al-Mg-Si alloys after long-time exploitation in research reactors

International Nuclear Information System (INIS)

Hofman, A.; Didyk, A.Yu.; Semina, V.K.; Szteke, W.; Hajewska, E.; Wagner, T.

2004-01-01

Effect of fast neutron (E > 0.1 MeV) irradiation on the mechanical properties and fracture morphology of the Al-Mg-Si alloys (PAR-1 and CAB-1) after 40 years of exploitation in research nuclear reactors has been studied. Tested specimens were cut from structural elements of reactor EWA (Swierk, Poland). Irradiation induces degradation in mechanical properties, namely yield strength and ultimate strength increase, but elongation reduces. The mechanical property changes are caused by ageing of Al-Mg-Si alloys. During irradiation Si is formed from Al by the Al(n, γ)Si reaction. The presence of Si might cause strengthening of the Al-Mg-Si alloys by increasing precipitation of Mg 2 Si or pure Si in the Al matrix. Post-irradiation activity studies of EWA reactor structural elements show that the high-activity 60 Co and 65 Zn isotopes have been formed by the nuclear reactions

WYKSZTAŁCENIE ABSOLWENTÓW ELEMENTEM KSZTAŁTOWANIA POZYCJI RYNKOWEJ UCZELNI

OpenAIRE

Szczepańska-Woszczyna, Katarzyna

2004-01-01

Przyjmując jako fakt powstanie i istnienie w Polsce rynku usług edukacyjnych na poziomie wyższym (koncepcja rynku edukacyjnego) należy traktować wykształcenie jako produkt rynkowy. W artykule przedstawiono wykształcenie jako produkt powstały w wyniku świadczenia usługi edukacyjnej, którego jakość kształtuje wizerunek uczelni, która ten produkt "wytworzyła". Miarą sukcesu uczelni jest pozycja jej absolwentów na rynku pracy. Katarzyna Szczepańska

Postsotsialistlik Eesti filmikunst kui rahvusülene kino / Ewa Mazierska

Index Scriptorium Estoniae

Mazierska, Ewa

2011-01-01

Käsitletakse Nõukogude Liidu lagunemise järel valminud Eesti filme, võrreldes neid mujal ja teisel ajal loodud linateostega. Võrdluse tulemusena selgub, et Eesti film on pidevas dialoogis Euroopa ja maailma kinoga, ent suudab rääkida ka oma häälega, et ta on nii rahvuslik kui ka rahvusülene nähtus, suutes ka ise midagi teistele pakkuda

Tegn. Red.

African Journals Online (AJOL)

rbr

gawe uit meer as twee maal soveel lemmas sal bestaan. Selfs tien duisend lem- mas sal geensins 'n volledige versameling "etimologiseerbare" Afrikaanse lemmas verteenwoordig nie, en dit is goed dat EWA geensins makrostruktu- rele volledigheid op die agenda het nie. Nogtans, hoewel daar in hierdie stadium niks oor ...

West African Journal of Applied Ecology - Vol 9, No 1 (2006)

African Journals Online (AJOL)

Ecological effects of channelization on a tropical marine ecosystem: Impact on intertidal fish communities in the Cross River, Nigeria · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. IO Ewa-Oboho. http://dx.doi.org/10.4314/wajae.v9i1.45674 ...

Natsionalism: positiivne või negatiivne? / Eva Fotiadi, Martin Krenn, Katarzyna Ruchel-Stockmans, Reet Varblane ; intervjueerinud Rael Artel

Index Scriptorium Estoniae

Fotiadi, Eva

2009-01-01

27. märtsil toimus Kumu Kunstimuuseumis "Public Preparation'i" ("Avalik ettevalmistus") sarja rahvusvaheline seminar "Translocal Express. Golden Age" ("Translokaalne ekspress. Kuldaeg"), mille eesmärk oli koondada mitmete regioonide arusaamu selle kohta, millist rolli mängivad ajalookirjutus ja kollektiivne mälu praegu domineerivas natsionalistlikus diskursuses ja kuidas käsitlevad seda problemaatikat oma loomingus kunstnikud. Oma uusimaid teoseid tutvustasid kunstnikud Martin Krenn (Viin) ja Kristina Norman. Vestlusring seminarijärgsel päeval Sirbi toimetuses

What's Wrong with Copyright: Educator Strategies for Dealing with Analog Copyright Law in a Digital World

Science.gov (United States)

McGrail, J. Patrick; McGrail, Ewa

2009-01-01

Current copyright law was formulated before the digital technology became widely available and well before Web 2.0 changed the way that information is created and shared. J. Patrick McGrail and Ewa McGrail argue that copyright law has failed to keep up with the social and legal changes that have accompanied the technological developments of the…

Rodzina imigrancka z perspektywy historycznej: doświadczenia polskich pionierów w Winnipeg, 1896-1919

OpenAIRE

ALBAŃSKI, ŁUKASZ

2011-01-01

This paper focuses on an early Polish family life in Winnipeg. The family often served as a mechanism to reduce a sense of dislocation and to facilitate immigrants' adaptation. The family was also the primary economic unit. The family relations were affected by gender. Both immigrant men and women found themselves reconsidering traditional roles. Somehow immigration tested their family roles in newways. Ewa Jurczyk-Romanowska

Vanadust käsitlev projekt Tallinna Kunstihoones

Index Scriptorium Estoniae

2005-01-01

Tallinna Kunstihoones Reet Varblase kureeritud näitus "Homo grandis natu", mis käsitleb vanaduse ja vananemise tähendust ja rolli praeguses ühiskonnas. Osalejaid: Boaz Tal, Eveli Varik, Ly Lestberg, Mare Mikof, Aili Vahtrapuu, Jaan Paavle, Terje Ojaver, Marge Monko, Terje Tunis, Tatjana Antoshina, Valeri Vinogradov, Peeter Laurits, Toomas Kalve, Jüri Ojaver. 15. IV toimuva seminari "Eesti vananemispoliitika täna ja homme" ning 21., 28. IV, 5., 12. V toimuva loengusarja kava. 16. IV peab Boaz Tal loengu arhetüüpidest ja mälust, tutvustab oma töid. 21. IV avatakse Katarzyna Kozyra videoinstallatsioon "Naiste saun". 2. V performance'i-festival "Diverse universe", loetletud osalejaid

A control and recording system for a neutron diffractometer

International Nuclear Information System (INIS)

Czech, Z.; Turek, L.; Wierzewski, K.

1982-01-01

A digital system for automatic control and data recording being a part of a neutron diffractometer designed for measurement of the angular distribution of monochromatic neutrons is described. The system is built using digital TTL integrated circuits. Particular attention is drawn to the interesting design of the optimized cross-matrix which selects the elements subjected to recording. The system successfully works with the neutron diffractometer at the EWA reactor. (author)

Radiation waste management in Poland; Unieszkodliwianie odpadow promieniotworczych w Polsce

Energy Technology Data Exchange (ETDEWEB)

Tomczak, W. [Institute of Atomic Energy, Otwock-Swierk (Poland)

1995-12-31

Radioactive waste management especially related to storage of spent fuel from Ewa and Maria research nuclear reactors has been presented. The classification and balance of radioactive wastes coming from different branches of nuclear activities have been shown. The methods of their treatment in respect of physical state and radioactive have been performed as well as their storage in Central Polish Repository have been introduced. 2 figs, 4 tabs.

Radiation waste management in Poland

International Nuclear Information System (INIS)

Tomczak, W.

1995-01-01

Radioactive waste management especially related to storage of spent fuel from Ewa and Maria research nuclear reactors has been presented. The classification and balance of radioactive wastes coming from different branches of nuclear activities have been shown. The methods of their treatment in respect of physical state and radioactive have been performed as well as their storage in Central Polish Repository have been introduced. 2 figs, 4 tabs

Archaeological and Paleontological Salvage at Barbers Point, Oahu

Science.gov (United States)

1978-03-01

Ewa Plain, a former coral-algae calcareous reef that emerged following the post-Pleistocene sea-level subsidence. The topography that usually results...endangered floral species are present in this area, as well as several other rare and uncommon plants . No endangered species of fauna are recorded from...larger pits was used for cultivation and even today one comes upon bananas and Hawaiian sugarcane still growing in them [McAllister 1933:1091

“Polish” Rilke

Directory of Open Access Journals (Sweden)

Jerzy Kałążny

2012-01-01

Full Text Available The publication of Katarzyna Kuczyńska-Koschany’s book Rycerz i Śmierć. O Elegiach duinejskich Rainera Marii Rilkego fills the large gap in Polish research on Rilke as it is the first monographic study of the Duino elegies. The author of the book interprets individual elegies and Atical sensibility. Simultaneously, the author supports her analysis with the theoretical foundations created by acclaimed and reputed German researchers of Rilke’s literary output such as Käte Hamburger, Beda Allemann, Manfred Engel and Jacob Steiner, among others. In her considerations, the author also refers to Polish translation of the elegies, notably those made by Mieczysław Jastrun and Adam Pomorski, also providing their critical interpretation.

Wywiad z Ewą Gąsowską

Directory of Open Access Journals (Sweden)

Monika Stec

2014-06-01

Full Text Available An interview with Ewa Gąsowska In the interview, Ewa Gąsowska described her ten-year-long struggle with the Polish legal system. Gąsowska’s objective has been to reinstate the good name of her grandfather, Jan Rybak, who was murdered in 1945. According to Gąsowska, the reason for her grandfather’s death was his political activity in PPR (Polish Labourers’ Party and his post-war commitment to the reconstruction of People’s Poland (Polska Rzeczpospolita Ludowa. Gąsowska claims that he was murdered by members of Narodowe Siły Zbrojne (National Armed Forces. Almost 60 years after the death of Jan Rybak, a book was published which presents his activity and death in a different light. The book had been written by one of those regarded by Rybak’s family as his murderers. This “courtroom drama” is situated in the context of the relations between the Rybak family and the local community (the place where Jan Rybak, and most likely also his murderers, were born, as well as the socio-political transformations in the contemporary Poland.   Wywiad z Ewą Gąsowską Ewa Gąsowska opowiada historię swoich dziesięcioletnich zmagań z wymiarem sprawiedliwości. Jej celem jest rehabilitacja dobrego imienia dziadka, Jana Rybaka, który został zamordowany w 1945 roku. Zdaniem Ewy Gąsowskiej, powodem zabójstwa była partyjna aktywność jej dziadka (PPR i jego powojenne zaangażowanie w odbudowę Polski Ludowej, a jego mordercami byli członkowie Narodowych Sił Zbrojnych. Prawie 60 lat później ukazała się książka wspomnieniowa, która inaczej przedstawia działalność i okoliczności śmierci Jana Rybaka. Jej autorem jest osoba, którą rodzina uważa za mordercę. Ważny kontekst tego „serialu sądowego” stanowią relacje rodziny Rybaka z lokalną społecznością, z której się wywodzi on i – prawdopodobnie – jego zabójcy, jak też przemiany społeczno-polityczne we współczesnej Polsce.

Pracoholizm w kategoriach deprecjacji pracy pielęgniarki. Wybrane aspekty = Workaholism in categories of nurses’ work depreciation. Chosen aspects

OpenAIRE

Stychno, Ewa; Kulczycka, Kinga

2016-01-01

Stychno Ewa, Kulczycka Kinga. Pracoholizm w kategoriach deprecjacji pracy pielęgniarki. Wybrane aspekty = Workaholism in categories of nurses’ work depreciation. Chosen aspects. Journal of Education, Health and Sport. 2016;6(10):11-21. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.159507 http://ojs.ukw.edu.pl/index.php/johs/article/view/3920 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12....

Impacts of Freshwater Impoundment in the West Loch of Pearl Harbor

Science.gov (United States)

1993-05-01

absence of applicable non-point standards, the "Yellow Book" criteria for freshwater aquatic life or domestic water supply could be applied to evaluate the...Waimalu, Waipahu, Wahiawa, and Ewa water use districts and contains the largest groundwater body on Oahu, supplying more than 50 percent of the island’s...irrigation; desalt existing brackish water supplies, and; 3 create a freshwater impoundment in West Loch. 6I I I The Board of Water Supply (BWS) and

ESI-HI65 Ewa, Island of Oahu, Hawaii 2001 (Environmental Sensitivity Index Map)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

Physical and psychosocial indicators among office workers from public sector with and without musculoskeletal symptoms.

Science.gov (United States)

Barbieri, Dechristian França; Nogueira, Helen Cristina; Bergamin, Letícia Januário; Oliveira, Ana Beatriz

2012-01-01

Work-related musculoskeletal disorders (WRMD) are the result of the combination of different risk factors. They are very common among computer workers, mainly when neck and upper limbs are considered. Forty-two office workers from a public university participated in this study. They were divided into two groups: Symptomatic Subjects (SS, n=20) and Asymptomatic Subjects (AS, n=22), according to the Nordic Musculoskeletal Questionnaire (NMQ). Psychosocial indicators were assessed using the Job Content Questionnaire (JCQ) and Utrecht Work Engagement Scale (UWES). Workplaces were evaluated according to the Ergonomic Workplace Analysis (EWA), proposed by the Finnish Institute of Occupational Health. The NMQ showed higher weekly prevalence of complaints on neck, shoulders and wrist/hands (p=0.00) among SS. The annual prevalence of symptoms on wrist/hands was also higher among SS (p=0.02). The JCQ did not show any difference between groups (p>0.05). Higher proportion of servers with 'high level' of engagement, dedication and absorption, according to UWES, was identified among SS (p<0.01). EWA showed worse scores for 'Work Site', 'Job Content' and 'Repetitiveness of the Work' among SS (p<0.05). Servers are exposed to physical and psychosocial risk factors that can contribute to the development of WRMD. Work conditions need to be change in order to improve musculoskeletal health.

NEpiC: a network-assisted algorithm for epigenetic studies using mean and variance combined signals.

Science.gov (United States)

Ruan, Peifeng; Shen, Jing; Santella, Regina M; Zhou, Shuigeng; Wang, Shuang

2016-09-19

DNA methylation plays an important role in many biological processes. Existing epigenome-wide association studies (EWAS) have successfully identified aberrantly methylated genes in many diseases and disorders with most studies focusing on analysing methylation sites one at a time. Incorporating prior biological information such as biological networks has been proven to be powerful in identifying disease-associated genes in both gene expression studies and genome-wide association studies (GWAS) but has been under studied in EWAS. Although recent studies have noticed that there are differences in methylation variation in different groups, only a few existing methods consider variance signals in DNA methylation studies. Here, we present a network-assisted algorithm, NEpiC, that combines both mean and variance signals in searching for differentially methylated sub-networks using the protein-protein interaction (PPI) network. In simulation studies, we demonstrate the power gain from using both the prior biological information and variance signals compared to using either of the two or neither information. Applications to several DNA methylation datasets from the Cancer Genome Atlas (TCGA) project and DNA methylation data on hepatocellular carcinoma (HCC) from the Columbia University Medical Center (CUMC) suggest that the proposed NEpiC algorithm identifies more cancer-related genes and generates better replication results. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Pracoholizm w kategoriach deprecjacji pracy pielęgniarki. Wybrane aspekty = Workaholism in categories of nurses’ work depreciation. Chosen aspects

OpenAIRE

Ewa Stychno; Kinga Kulczycka

2016-01-01

Stychno Ewa, Kulczycka Kinga. Pracoholizm w kategoriach deprecjacji pracy pielęgniarki. Wybrane aspekty = Workaholism in categories of nurses’ work depreciation. Chosen aspects. Journal of Education, Health and Sport. 2016;6(10):11-21. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.159507 http://ojs.ukw.edu.pl/index.php/johs/article/view/3920       The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2...

Ergonomics and design in the Brazilian agricultural sector: a proposal to build matrix of contradictions.

Science.gov (United States)

Tosetto, Thaís; Camarotto, João Alberto

2012-01-01

The paper presents a correlation between the parameters of classical TRIZ and variables of analysis of the EWA to construct a matrix of contradictions in ergonomics, with the objective of assisting the designing processes in the Brazilian agricultural sector. Given the representativeness of the sector in the economy, the boundary conditions in which the activities are developed and their impact on the health of workers, this proposal should contribute to the development of adaptable solutions and the promotion of Decent Work.

School adolescents' knowledge concerning hepatitis C virus (HCV)

OpenAIRE

Sierpińska, Lidia; Jankowska, Ewa

2017-01-01

Sierpińska Lidia, Jankowska Ewa. School adolescents’ knowledge concerning hepatitis C virus (HCV). Journal of Education, Health and Sport. 2017;7(1):11-27. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.229140 http://ojs.ukw.edu.pl/index.php/johs/article/view/4133 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016). 754 Journal of Education, Health and Sport eISSN 2391-8306 7 © Th...

Epigenome-wide association study of DNA methylation in narcolepsy: an integrated genetic and epigenetic approach.

Science.gov (United States)

Shimada, Mihoko; Miyagawa, Taku; Toyoda, Hiromi; Tokunaga, Katsushi; Honda, Makoto

2018-04-01

Narcolepsy with cataplexy, which is a hypersomnia characterized by excessive daytime sleepiness and cataplexy, is a multifactorial disease caused by both genetic and environmental factors. Several genetic factors including HLA-DQB1*06:02 have been identified; however, the disease etiology is still unclear. Epigenetic modifications, such as DNA methylation, have been suggested to play an important role in the pathogenesis of complex diseases. Here, we examined DNA methylation profiles of blood samples from narcolepsy and healthy control individuals and performed an epigenome-wide association study (EWAS) to investigate methylation loci associated with narcolepsy. Moreover, data from the EWAS and a previously performed narcolepsy genome-wide association study were integrated to search for methylation loci with causal links to the disease. We found that (1) genes annotated to the top-ranked differentially methylated positions (DMPs) in narcolepsy were associated with pathways of hormone secretion and monocarboxylic acid metabolism. (2) Top-ranked narcolepsy-associated DMPs were significantly more abundant in non-CpG island regions and more than 95 per cent of such sites were hypomethylated in narcolepsy patients. (3) The integrative analysis identified the CCR3 region where both a single methylation site and multiple single-nucleotide polymorphisms were found to be associated with the disease as a candidate region responsible for narcolepsy. The findings of this study suggest the importance of future replication studies, using methylation technologies with wider genome coverage and/or larger number of samples, to confirm and expand on these results.

Costs and benefits of biological control of invasive alien plants in South Africa

CSIR Research Space (South Africa)

Van Wilgen, BW

2011-08-01

Full Text Available ba se d on w ate r pr od uc tio n, w ild flo we r ha rv es t, hik er vis ita tio n, ecotourism ,endemi cspecie san dgeneti cstorage . Valu ewa s US$ 3millio n (wit hn o managemen to falie n plants) ,an... is the most important), and on poverty alleviation (through the employment of disadvantaged people in rural areas). Currently, WfW has an annual operating budget of approxi- mately R500 million, and the way in which this budget is subdivided provides...

Przygotowanie pacjentów z cukrzycą typu 2 do profilaktyki zespołu stopy cukrzycowej = Preparing patients with type 2 diabetes to prophylaxis of diabetic foot

OpenAIRE

Kropornicka, Beata; Baczewska, Bożena; Dadej, Aleksandra; Krzyżanowska, Ewa; Łuczyk, Robert; Olszak, Cecylia; Nowicka, Elżbieta; Lorencowicz, Regina; Muraczyńska, Bożena

2016-01-01

Kropornicka Beata, Baczewska Bożena, Dadej Aleksandra, Krzyżanowska Ewa, Łuczyk Robert, Olszak Cecylia, Nowicka Elżbieta, Lorencowicz Regina, Muraczyńska Bożena. Przygotowanie pacjentów z cukrzycą typu 2 do profilaktyki zespołu stopy cukrzycowej = Preparing patients with type 2 diabetes to prophylaxis of diabetic foot. Journal of Education, Health and Sport. 2016;6(11):311-324. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.167141 http://ojs.ukw.edu.pl/index.php/johs/article/view/3...

Zaburzenia odżywiania – problem wciąż aktualny = Eating disorders – an ongoing problem

OpenAIRE

Rzońca, Ewa; Bień, Agnieszka; Iwanowicz-Palus, Grażyna

2016-01-01

Rzońca Ewa, Bień Agnieszka, Iwanowicz-Palus Grażyna. Zaburzenia odżywiania – problem wciąż aktualny = Eating disorders – an ongoing problem. Journal of Education, Health and Sport. 2016;6(12):267-273. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.198734 http://ojs.ukw.edu.pl/index.php/johs/article/view/4053 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Edu...

Zaburzenia odżywiania – problem wciąż aktualny = Eating disorders – an ongoing problem

OpenAIRE

Ewa Rzońca; Agnieszka Bień; Grażyna Iwanowicz-Palus

2016-01-01

Rzońca Ewa, Bień Agnieszka, Iwanowicz-Palus Grażyna. Zaburzenia odżywiania – problem wciąż aktualny = Eating disorders – an ongoing problem. Journal of Education, Health and Sport. 2016;6(12):267-273. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.198734 http://ojs.ukw.edu.pl/index.php/johs/article/view/4053         The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Educa...

Analysis of Field Activity Perspectives of Centralized Non-Appropriated Fund Accounting, Banking, and Payroll Procedures within the Department of the Navy.

Science.gov (United States)

1982-06-01

4 aN U N J G - @ N 4 0 49 "f*U’ aW ..- fta .0* IAU = 0 6~ U) x 3. -- a- - U N N j w .0 46FANU an4 U 4 ~ ~ ~ ~ ~ l UN 4 . E r- a , a- X a.I IL0.2.a’ a...Planning and Management 204 1I 3 374%A622 USEPIES OF THE FMD SOL==C SECTION OP E!WAS BAIA= M AID E Tota Number of Acti.ities for Wbhch Basponws Were ftn

SOCIAL PARTICIPATION IN THE ENVIRONMENTAL FLOW ASSESSMENT: THE SÃO FRANCISCO RIVER CASE STUDY

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Yvonilde Dantas Pinto Medeiros

2013-03-01

Full Text Available Traditionally, water resource management has been developed using an essentially technical approach. Currently, public opinion on water resource management is formed as a result of growing environmental concerns and social conflicts arising from poorly planned actions. Environmental problems are complex and have multiple dimensions, including social and economic. Therefore, the inclusion of a human dimension in integrated assessment methodologies is required for the introduction of new elements to the water management planning process. Environmental water allocation (EWA is understood as the quantity, quality and distribution of water required for the maintenance of the functions and processes of aquatic ecosystems on which people depend. Within the various holistic assessment methodologies, the Building Block Methodology (BBM was found to be the most suitable, in the Brazilian context, for maintaining and restoring essential elements of the natural flow regime. This article describes the process of social participation in the environmental flow assessment (EFA for the Sao Francisco River, and compares it with some of the lessons learned from EFA in other parts of the world. The process involved multiple stakeholders who have conflicting interests. BBM was used to guide the field interviews, to incorporate the empirical observations by the local population and to guide the methodological procedures of the multidisciplinary team. The results of the study indicate the effectiveness of this holistic approach in organizing the elements to be evaluated. It also facilitated important contributions to the establishment of a dialogue between the actors to achieve a better understanding of the multiple aspects involved in the decisions associated with the EWA.

General Aviation Activity and Avionics Survey 1982.

Science.gov (United States)

1983-12-01

is F- C- i I.. <Z< 04K 4 K 4 K mm <.1 -.5 9.JO M 5 I. .J0 - AI. C 1.-’ 01- 1 0 0 -. t- 0 t- a 00 o 0 o0 mo0 w 0 is owe ao Ewa wm wo iso - 24 .0 4%~ 4...0540 41531 PCKARDV1650 49001 FRNKLN4AC50 27002 LYC 0540 41532 PWA 6T02 dT12 FRNKLN4AC0 27003 LYC 0540 41533 PWA JT12 52042 FRNKLN4AC10 27004 LYC 0540

Response to “Oral health in the elderly patient and its impact on general well-being: a nonsystematic review” paper

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Muc-Wierzgoń M

2015-05-01

Full Text Available Malgorzata Muc-Wierzgoń, Teresa Kokot, Ewa Nowakowska-Zajdel, Adam Błażelonis, Edyta Fatyga Department of Internal Medicine, Silesian Medical University, Bytom, PolandDear editorGil-Montoya et al has recently published an interesting article in Clinical Interventions in Aging entitled: “Oral health in the elderly patient and its impact on general well-being: a nonsystematic review”.1 Authors presented a non-systematic review of the published data regarding the oral health status of the elderly and its main repercussions, including its impact on general health and nutrition.View original paper by Gil-Montoya and colleagues.

Adverse outcomes after percutaneous dilatational tracheostomy versus surgical tracheostomy in intensive care patients: case series and literature review

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Jarosz K

2017-08-01

Full Text Available Konrad Jarosz,1 Bartosz Kubisa,2 Agata Andrzejewska,3 Katarzyna Mrówczyńska,3 Zbigniew Hamerlak,4 Alicja Bartkowska-Śniatkowska5 1Department of Clinical Nursing, Pomeranian Medical University, 2Thoracic Surgery and Transplantation Department, Pomeranian Medical University, 3Anaesthesiology and Intensive Care Department, Pomeranian Medical University, 4Stomatology Department, Pomeranian Medical University, 5Anaesthesiology and Pediatric Intensive Care Department, Poznan University of Medical Sciences, Szczecin, Poland Abstract: Tracheostomy is a routinely done procedure in the setting of intensive care unit (ICU in patients requiring prolonged mechanical ventilation. There are two ways of making a tracheostomy: an open surgical tracheostomy and percutaneous dilatational tracheostomy. Percutaneous dilatational tracheostomy is associated with fewer complications than open tracheostomy. In this study, we would like to compare both techniques of performing a tracheostomy in ICU patients and to present possible complications, methods of diagnosing and treating and minimizing their risk. Keywords: tracheostomy, percutaneous tracheostomy, percutaneous dilatational tracheostomy, bronchoscopy, surgical tracheostomy, tracheoesophageal fistula, tracheostomy complications

S-adenosylmethionine blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo: therapeutic and diagnostic clinical applications

International Nuclear Information System (INIS)

Parashar, Surabhi; Cheishvili, David; Arakelian, Ani; Hussain, Zahid; Tanvir, Imrana; Khan, Haseeb Ahmed; Szyf, Moshe; Rabbani, Shafaat A

2015-01-01

Osteosarcoma (OS) is an aggressive and highly metastatic form of primary bone cancer affecting young children and adults. Previous studies have shown that hypomethylation of critical genes is driving metastasis. Here, we examine whether hypermethylation treatment can block OS growth and pulmonary metastasis. Human OS cells LM-7 and MG-63 were treated with the ubiquitous methyl donor S-adenosylmethionine (SAM) or its inactive analog S-adenosylhomocystine (SAH) as control. Treatment with SAM resulted in a dose-dependent inhibition of tumor cell proliferation, invasion, cell migration, and cell cycle characteristics. Inoculation of cells treated with 150 μmol/L SAM for 6 days into tibia or via intravenous route into Fox Chase severe combined immune deficient (SCID) mice resulted in the development of significantly smaller skeletal lesions and a marked reduction in pulmonary metastasis as compared to control groups. Epigenome wide association studies (EWAS) showed differential methylation of several genes involved in OS progression and prominent signaling pathways implicated in bone formation, wound healing, and tumor progression in SAM-treated LM-7 cells. Real-time polymerase chain reaction (qPCR) analysis confirmed that SAM treatment blocked the expression of several prometastatic genes and additional genes identified by EWAS analysis. Immunohistochemical analysis of normal human bone and tissue array from OS patients showed significantly high levels of expression of one of the identified gene platelet-derived growth factor alpha (PDGFA). These studies provide a possible mechanism for the role of DNA demethylation in the development and metastasis of OS to provide a rationale for the use of hypermethylation therapy for OS patients and identify new targets for monitoring OS development and progression

Activities in the field of nuclear reactor instrumentation and control in Poland - 1991 status

International Nuclear Information System (INIS)

Mikulski, A.T.

1992-01-01

The report gives a condensed overview of activity in the field of nuclear reactor instrumentation and control in Poland over the last few years. The work was performed parallel in two directions related to the construction of the first Nuclear Power Plant at Zarnowlec and to the changes made for two research reactors at Swierk. The first direction, according to government decision, was cancelled at the end of 1990 and the results obtained up to now are briefly summarized. The second one is in progress, some minor changes in I and C for the EWA reactor and significant improvements for the MARIA reactor are under way. The results of this activity are presented. (author). 6 refs

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis

DEFF Research Database (Denmark)

Svendsen, Anders J; Gervin, Kristina; Lyle, Robert

2016-01-01

: Smoking was significantly associated with hypomethylation of a DMR overlapping the promoter region of the RNF5 and the AGPAT1, which are implicated in inflammation and autoimmunity, whereas DMARD treatment induced hypermethylation of the same region. Additionally, the promotor region of both S100A6......OBJECTIVES: In an explorative epigenome-wide association study (EWAS) to search for gene independent, differentially methylated DNA positions and regions (DMRs) associated with rheumatoid arthritis (RA) by studying monozygotic (MZ) twin pairs discordant for RA. METHODS: Genomic DNA was isolated......: We identified several differentially methylated regions associated with RA, which may represent environmental effects or consequences of the disease and plausible biological pathways pertinent to the pathogenesis of RA....

A fruitful encounter between Cognitive Science and Science & Technology Studies

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Aleksandra Derra

2013-06-01

Full Text Available Scholars deriving from different schools of thought, especially if these grow out of different traditions, do not meet too frequently, and it is even more rare for these meeting to result in creating theories or research practices that would be cognitively surprising or rich in refreshing ideas. Therefore, the material we present in the current issue of Avant (1/2013 is exceptional. In the following part you can read articles by representatives of the so-called Toruń (postconstructivist school, “(Postconstructivism on the subject of techno-science” by Ewa Bińczyk and “A-socio-logy of a condition. A study of controversies surrounding etiology, diagnosis and therapy of ADHD” by Łukasz Afeltowicz and Michał Wróblewski.

The Spanish mysticism in paintings by artists from the Fine Arts Academy in Krakow at the turn of the 21st century

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Adam Organisty

2016-12-01

Full Text Available During the last two decades the works of teachers from the Painting Department of the Academy of Fine Arts in Krakow: Grzegorz Bednarski, Katarzyna Makieła-Organisty, Janusz Matuszewski, Mirosław Sikorski, Edyta Sobieraj, Zbigniew Sprycha or Wojciech Szybist reveal traces of inspiration by the Spanish Golden Age. In this respect, paintings by Krakow artists stand out against other works of contemporary art both in Poland and globally. Their art should be discussed in the context of early modern meditatio mortis and tenebristic „baroqueism”, to which the artists themselves readily admit. The point of departure (frequently referred to as homage are mystic visions, portraits by El Greco, Francisco de Zurbarán’s bodegóns or eschatological „death hieroglyphics” by Juan de Valdés Léal. References to works by the Iberian masters are accompanied by links to Carmelite writings or Jesuit mystics. Formal and ideological analysis also allows us to ask a question of the possibility of presenting the „mystic theology” described by St. Theresa of the Infant Jesus, St. John of the Cross or St. Ignatius of Loyola in contemporary religious paintings.

Jllumina

DEFF Research Database (Denmark)

Almeida, Diogo Marinho; Uhrenfeldt Skov, Ida; Lund, Jesper

2016-01-01

enabling high quality and statistically sound downstream analyses. As of yet, only R-based solutions are freely available for low-level processing of the Illumina chip data. However, the lack of alternative libraries poses a hurdle for the development of new bioinformatic tools, in particular when it comes...... to web services or applications where run time and memory consumption matter, or EWAS data analysis is an integrative part of a bigger framework or data analysis pipeline. We have therefore developed and implemented Jllumina, an open-source Java library for raw data manipulation of Illumina Infinium...... HumanMethylation450 and Infinium MethylationEPIC BeadChip data, supporting the developer with Java functions covering reading and preprocessing the raw data, down to statistical assessment, permutation tests, and identification of differentially methylated loci....

Epigenetics and cerebral organoids

DEFF Research Database (Denmark)

Forsberg, Sheena Louise; Ilieva, Mirolyuba; Maria Michel, Tanja

2018-01-01

also play a role. Some studies indicate a set of candidate genes with different DNA methylation profiles in ASD compared to healthy individuals. Thus epigenetic alterations could help bridging the gene-environment gap in deciphering the underlying neurobiology of autism. However, epigenome......-wide association studies (EWAS) have mainly included a very limited number of postmortem brain samples. Hence, cellular models mimicking brain development in vitro will be of great importance to study the critical epigenetic alterations and when they might happen. This review will give an overview of the state...... of the art concerning knowledge on epigenetic changes in autism and how new, cutting edge expertise based on three-dimensional (3D) stem cell technology models (brain organoids) can contribute in elucidating the multiple aspects of disease mechanisms....

Analysis of the workload of bank tellers of a Brazilian public institution.

Science.gov (United States)

Serikawa, Simoni S; Albieri, Ana Carolina S; Bonugli, Gustavo P; Greghi, Marina F

2012-01-01

During the last decades there have been many changes in the banking sector organization. It has been also observed the mutual growing of musculoskeletal and mental disorders. This study investigated the workload of bank tellers at a Brazilian public institution. It was performed the Ergonomic Work Analysis (EWA). Three employees participated in this study. During the analysis process, three research instruments were applied: Inventory of Work and Risk of Illness, Yoshitake Fatigue Questionnaire and Nordic Musculoskeletal Questionnaire, beyond the realization of footage recordings and the self-confrontation. The results indicated the existence of an excess of workload on the evaluated workstations, mainly in relation to mental order constraints, that overlaps the physical aspects. Thereby it was found that the employees tend to adopt strategies trying to reduce the impacts of the excess of workload, in order to regulate it.

Kolory poezji (Na przykładzie poezji lirycznej Konstantego Ildefonsa Gałczyńskiego

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Agnieszka Rydz

2016-06-01

Full Text Available The article presents the category of colour in modern Polish poetry, and based on an interpretation of Ewa Górecka’s book, Konstatnego Ildefonsa Gałczyńskiego gry barwą z wyobraźnią i kulturą [Colours as Konstanty Ildefons Gałczyński’s Play with Imagination and Culture]. The colour palette in Gałczyński’s poetry includes golden, silver, green, blue, red and black. Culture was an inspiration for the poet, but he didn’t avoid entering into dialogue with it, establishing the meanings of colours in his writing. The colours present in Gałczyński’s lyric poetry also indicate the changes in his poetic language. The way in which the poet uses them in his early works differs from their use in those created after 1945.

Efficient detection of differentially methylated regions using DiMmeR

DEFF Research Database (Denmark)

Almeida, Diogo Marinho; Uhrenfeldt Skov, Ida; Silva, Artur

2017-01-01

in the programming language R, have no user interface, and do not offer all necessary steps to guide users from raw data all the way down to statistically significant differentially methylated regions (DMRs) and the associated genes. RESULTS: Here, we present DiMmeR (Discovery of Multiple Differentially Methylated...... Regions), the first free standalone software that interactively guides with a user-friendly graphical user interface (GUI) scientists the whole way through EWAS data analysis. It offers parallelized statistical methods for efficiently identifying DMRs in both Illumina 450K and 850K EPIC chip data. Di......MmeR computes empirical p-values through randomization tests, even for big data sets of hundreds of patients and thousands of permutations within a few minutes on a standard desktop PC. It is independent of any third-party libraries, computes regression coefficients, p-values and empirical p...

Reading Muranów. Memory of a place / memory of an architect. Commentary on the postwar work of Bohdan Lachert

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Uchowicz, Katarzyna

2014-12-01

Full Text Available The text concentrates on the concept of South Muranów – a residential quarter / monument realised in the area of the Warsaw ghetto by the architect Bohdan Lachert. It attempts to show this work as an artistic myth created by the artist. An analysis of the architect's texts and a reconstruction of the circumstances in which the project was realised, as well as the details of Lachert's biography reveal new layers of this architectonic palimpsest. Clear references to the bold visions of Śródmieście (City Centre by Maciej Nowicki and an adaptation for the purposes of residential quarter / place of memory experiments at transforming rubble, popular in the 1940s, provoke questions about the originality of the concept of Muranów, whose unquestionable value is the spatial composition stemming from pioneering experiments by Katarzyna Kobro, organic architecture of Frank Lloyd Wright, and Nowicki'c new functionalism. The history of the quarter is at the same time a microcosm of the initial years of rebuilding Warsaw and of the socialist realist chaos after 1949, as well as a record of the search for artistic subjectivity of a Modernist architect in a new reality.

Recent developments on the role of epigenetics in obesity and metabolic disease.

Science.gov (United States)

van Dijk, Susan J; Tellam, Ross L; Morrison, Janna L; Muhlhausler, Beverly S; Molloy, Peter L

2015-01-01

The increased prevalence of obesity and related comorbidities is a major public health problem. While genetic factors undoubtedly play a role in determining individual susceptibility to weight gain and obesity, the identified genetic variants only explain part of the variation. This has led to growing interest in understanding the potential role of epigenetics as a mediator of gene-environment interactions underlying the development of obesity and its associated comorbidities. Initial evidence in support of a role of epigenetics in obesity and type 2 diabetes mellitus (T2DM) was mainly provided by animal studies, which reported epigenetic changes in key metabolically important tissues following high-fat feeding and epigenetic differences between lean and obese animals and by human studies which showed epigenetic changes in obesity and T2DM candidate genes in obese/diabetic individuals. More recently, advances in epigenetic methodologies and the reduced cost of epigenome-wide association studies (EWAS) have led to a rapid expansion of studies in human populations. These studies have also reported epigenetic differences between obese/T2DM adults and healthy controls and epigenetic changes in association with nutritional, weight loss, and exercise interventions. There is also increasing evidence from both human and animal studies that the relationship between perinatal nutritional exposures and later risk of obesity and T2DM may be mediated by epigenetic changes in the offspring. The aim of this review is to summarize the most recent developments in this rapidly moving field, with a particular focus on human EWAS and studies investigating the impact of nutritional and lifestyle factors (both pre- and postnatal) on the epigenome and their relationship to metabolic health outcomes. The difficulties in distinguishing consequence from causality in these studies and the critical role of animal models for testing causal relationships and providing insight into underlying

Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins

DEFF Research Database (Denmark)

Starnawska, Anna; Tan, Qihua; McGue, Matt

2017-01-01

As the world's population ages, the age-related cognitive decline presents a great challenge to world's healthcare systems. One of the molecular mechanisms implicated in cognitive ageing is DNA methylation, an epigenetic modification known to be a key player in memory formation, maintenance......, and synaptic plasticity. Using the twin design we performed an epigenome-wide association study (EWAS) in a population of 486 middle-aged monozygotic twins (mean age at follow-up 65.9, SD = 6.1) and correlated their blood DNA methylation to their level (cross-sectional analysis) and change in cognitive...... abilities over 10 years (longitudinal analysis). We identified several CpG sites where cross-sectional cognitive functioning was associated with DNA methylation levels. The top identified loci were located in ZBTB46 (p = 5.84 × 10-7), and TAF12 (p = 4.91 × 10-7). KEGG's enrichment analyses of the most...

Investigation of the neutron detection statistics in fast critical assembly BFS-24-1

International Nuclear Information System (INIS)

Avramov, A.M.; Tyutyunnikov, P.L.; Mikulski, A.T.; Rafalska, E.; Chwaszczewski, S.; Jablonski, K.

1974-01-01

The results of the neutron detection statistics investigation at the fast critical assembly BFS-24-1 are given. The Ross-α measurements were carried out using: digital flash-start unit and 256 channel time analyzer, 10 channel time analyzer, alphameter device. Parallely the measurements using the variable dead time method and zero probability method were performed. The prompt neutron decay constants, the effectiveness of neutron detector and the intensity of external neutron source are determined using the experimental data. The experimental values of prompt neutron decay constant are compared with the calculated ones. The codes used in the calculation are following: one dimensional, diffusion, 26-group code 26-M and EWA-1, one dimensional, multiregion, nonstationary diffusion 3-group code SPECTR, 26-group, diffusion code in buckling approximation, MIXSPECTR. In all codes the 26 group nuclear constants BNAB-26 and BNAB-70 are used. (author)

The most important psychological and psychosocial needs of Polish multiple sclerosis patients and their significant others

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Potemkowski A

2017-07-01

Full Text Available Andrzej Potemkowski,1 Waldemar Brola,2,3 Anna Ratajczak,4 Marcin Ratajczak,5 Mariusz Kowalewski,6 Małgorzata Lewita,6 Katarzyna Kapica-Topczewska,7 Joanna Tarasiuk,7 Adam Stępień,8 Katarzyna Gocyła-Dudar,8 Jacek Zaborski,9 Halina Bartosik-Psujek10 1Department of Clinical Psychology and Psychoprophylaxis, University of Szczecin, 2Department of Neurology, Specialist Hospital, Końskie, 3The Faculty of Medicine and Health Science, Institute of Physiotherapy, Jan Kochanowski University, Kielce, 4Pomeranian Medical University, Szczecin, 5Clinical Trial Center for MS-Patients, Szczecin, 6John Paul II Multiple Sclerosis Rehabilitation Center, Borne Sulinowo, 7Department of Neurology, Medical University of Białystok, Białystok, 8Department of Neurology, Military Institute of Medicine, Warsaw, 9Department of Neurology, Specialist Hospital in Międzylesie, Warsaw, 10Medical Faculty, University of Rzeszów, Rzeszów, Poland Background: People with multiple sclerosis (MS and their relatives often have multiple, complex needs which require support from a wide range of services. The aim of the study, the first of its kind in Poland, was to identify the most important needs of patients with MS and their significant others (SO. Methods: A questionnaire developed from focus groups consisting of 20 needs-related statements was administered in seven MS centers to 573 MS patients and 220 SO. The mean age of the patients was 42.61 years old; the mean MS duration was 9.43 years. The respondents were asked to rate the needs statements according to their importance on an 11-point scale. The questionnaire was similar for the MS patients and their SO. Results: The most important needs in the patient group were: to feel needed and efficient in life; to have easy access to professional rehabilitation; and to be sure that doctors are interested in my condition. The three most important needs in the SO group were: to know that relatives/friends feel needed and

Neutrino physics in the spotlight

CERN Multimedia

2009-01-01

Following on from the Council recommendation made in Lisbon in 2006 and responding to the needs of a large community of scientists, CERN will organize the European Strategy for Future Neutrino Physics workshop on 1-3 October. One of the main goals of the workshop is to start establishing a roadmap for the coherent participation of Europe in neutrino physics."The format of the workshop will consist of invited talks to present the current situation and future possibilities; unlike other workshops, 30% of the time will be reserved for discussion", explains Ewa Rondio from the organising committee. "Resources for future neutrino experiments will be difficult to acquire. A coordinated approach and the participation of a large community of interested scientists are undoubtedly crucial factors". The workshop will be the opportunity to highlight the areas where substantial research and development activities are required in order to design the facilities of the next decade. "The w...

New insights and updated guidelines for epigenome-wide association studies

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Lisa H. Chadwick

2015-01-01

Full Text Available Epigenetic dysregulation in disease is increasingly studied as a potential mediator of pathophysiology. The epigenetic events are believed to occur in somatic cells, but the limited changes of DNA methylation in studies to date indicate that only subsets of the cells tested undergo epigenetic dysregulation. The recognition of this subpopulation effect indicates the need for care in design and execution of epigenome-wide association studies (EWASs, paying particular attention to confounding sources of variability. To maximize the sensitivity of the EWASs, ideally, the cell type mediating the disease should be tested, which is not always practical or ethical in human subjects. The value of using accessible cells as surrogates for the target, disease-mediating cell type has not been rigorously tested to date. In this review, participants in a workshop convened by the National Institutes of Health update EWAS design and execution guidelines to reflect new insights in the field.

Natural gas in Eastern Europe

Energy Technology Data Exchange (ETDEWEB)

Grabarczyk, Ewa; McCallum, Robert; Wergeland, Tor H

1994-12-31

The paper is based on Ewa Grabarczyk`s thesis ``The European Gas Market and the Former East Block Countries`` in the Master of International Business Programme at the Norwegian School of Economics and Business Administration. The material of Grabarczyk`s work has been split into two parts; SNF Working Papers Nos. 97/93 and 98/93. Working Paper 97/93 ``The European Gas Markets`` contains an equilibrium model of the European Gas Market employed to investigate some scenarios to the consequences of an integration of the former Soviet Union. Working Paper 98/93 ``Natural Gas in Eastern Europe`` contains descriptions of the energy sectors of former Eastern European countries and an evaluation of the potential future demand for natural gas in these nations. The paper has chapters on each country and sections on reserves, production, exports and markets, transport possibilities and technology, demand and development as well as evaluation of the present situation. 11 figs., 37 tabs., 33 refs

Nobel prize-winner Heinrich Rohrer visits CERN

CERN Document Server

2008-01-01

The Nobel prize-winner Heinrich Rohrer met young scientists on a recent visit to the Laboratory. From left to right: Xavier Gréhant (CERN Openlab), Ewa Stanecka (ATLAS), Magda Kowalska (ISOLDE), Heinrich Rohrer, Stéphanie Beauceron (CMS) and Ana Gago Da Silva (UNOSAT).Heinrich Rohrer, who shared the 1986 Nobel prize for physics with Gerd Binnig for the design of the scanning tunnelling microscope, visited CERN on 25 June. Welcomed by the Director-General, Robert Aymar, he visited the ATLAS cavern and control room, the Computer Centre, the Unosat project, the Antimatter Decelerator and ISOLDE. At the end of his visit, he voiced his admiration for CERN and its personnel. As a renowned Nobel prize-winner Heinrich Rohrer has the opportunity to pass on his experience and enthusiasm to young scientists. During the evening meal, at which he met five young physicists and computer scientists, who were delighted with the chance to talk to him, he stressed the importance for re...

On reading the “Duino Elegies” by Rainer Maria Rilke

Directory of Open Access Journals (Sweden)

Barbara Surowska

2012-01-01

Full Text Available The article discusses the book Rycerz i śmierć written by Katarzyna Kuczyńska-Koschany. The book includes essays on Reiner Maria Rilke’s Duino Elegies published earlier that have been revised and updated. The poem cycle called the Duino Elegies is composed of ten separate poems written in 1912, 1913, 1915 and 1922, i.e. at the peak period of the poet’s imagination and mental activity. The reviewer provides a detailed analysis the first four chapters of the book in which three elegies written before the outbreak of the first war, and the fourth that originated when the war was raging on, are presented. The reviewer appreciates the author’s careful preparation for the book and the ambitious agenda of the author to describe in a synthetic form, for the first time in Poland, the whole cycle of Rilke’s elegies with their Polish translations along with their quality evaluation and comparison taken into consideration, as well as some presentations of German interpretations from prominent specialists in the life and the literary output of Rilke. However, the reviewer is not ready to buy all of the author’s claims and points at numerous, perhaps too numerous, errors, distortions in facts and erroneous reading of the original texts written in German, which, to a high degree, lowers the perceived quality of the discussed book.

Taking care of you and care for others: an analysis of the activity of the work of technical and nursing assistants of a psychiatric institution for children and adolescents.

Science.gov (United States)

Mendes, Davidson Passos; Moraes, Geraldo Fabiano de Souza; Mendes, Juliana Cristina de Lima

2012-01-01

Our objective in this study, the analysis of potential fields of risk management in nursing work in psychiatric care to adolescents and children, while settings that go from the relationship between technical and organizational determinants of work activity and the skills of operators. It was established focus on the work process of the Technical and Nursing Assistants to seek for response elements in an attempt to understand the health-disease process experienced by these workers. It was used for analysis and data collection, through the method of Ergonomic Work Analysis (EWA), fifteen workers of nursing staff - T&NA, between effectives and contractors, and the strategies of action and regulation of these workers in relation to the interface that they deal with. The results show that the workers are exposed to all charges in an intense and specific way, causing physical and mental wear, as it approaches the psychological distress, exposure to the psychic pressure, not only through contact with the object of work, but the complexity of these relationships that are involved in nursing staff.

Essay and Ekphrasis (Herbert - Bieńkowska - Bieńczyk

Directory of Open Access Journals (Sweden)

Roma Sendyka

2009-01-01

Full Text Available Michel Riffaterre in article L'lllusion d'ekphrasis put forward an idea of "critical ekphrasis" (1994 what may become an invitation to ask if other sub-genres/modes of ekphrasis may be described. The text Essay and Ekphrasis develops this question in the field of essayistic traditions. Evoking the tendency of writing on art in that genre (from Montaigne, Diderot, Ruskin, Pater to art historians, critics and artists the article analyses three examples of ekphrases (by Zbigniew Herbert, Ewa Bieńkowska and Marek Bieńczyk to voice a hypothesis that ekphrasis in an essay may be a useful proof for those who question (ostensive representational powers of that textual tool. Essayistic ekphrasis seems to have a foremost referential character, pointing towards an object of art only to use it in order to describe cognitive procedures of the subject who in such a way (performatively and not overtly pictures himself mirroring his inner self in dispersed fragments of cultural object, dismantling the temporal and spatial difference between the viewer and the object in an illusion of an immediate presence.

How do users design? The case of sugar cane harvester machines.

Science.gov (United States)

Narimoto, Lidiane Regina; Camarotto, João Alberto

2017-01-01

Design in use and inventiveness are key concepts in ergonomics. It is well-known that users design but is not explored in the literature how they manage to do that. This paper aims to contribute to the discussion of how users actually design, by showing a research conducted in sugar cane harvesting in Brazil and in Australia. Through the methodology of the Ergonomic Work Analysis (EWA), the design modifications made by the harvesting teams were identified as well as their elaboration process. Three categories of modifications in machines' design were identified: structural, functional and operational and they were more numerous in Brazilian situations. It is proposed that two theories underlying the theme are intertwined: the instrument-mediated activity approach and the design as bricolage. It is argued that users design through the articulation of: a) the operators' activity, b) the mechanical technicians' inventory to practice bricolage as a way of designing and c) the work organisation and the existence of social spaces of interaction between these two subjects.

The impact of pelvic floor muscle training on the quality of life of women with urinary incontinence: a systematic literature review

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Radzimińska A

2018-05-01

Full Text Available Agnieszka Radzimińska, Agnieszka Strączyńska, Magdalena Weber-Rajek, Hanna Styczyńska, Katarzyna Strojek, Zuzanna Piekorz Department of Physiotherapy, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland Purpose: The purpose of this review was to assess the effectiveness of pelvic floor muscle training (PFMT in the treatment of urinary incontinence (UI in women, with a particular focus on the impact of this form of therapy on the patients’ quality of life (QoL. Methods: The following electronic databases were searched: PubMed, Embase, and Cochrane Library (articles only in English, 1990–2017. Search terms were as follows: urinary incontinence, pelvic floor muscle training, pelvic floor exercises, quality of life. Systematic review methods were based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results: The assessment of the impact of PFMT on the QoL of women with UI was conducted among 2,394 women in 24 selected studies. After the end of treatment, the majority of patients in the experimental groups noted a statistically significant improvement in QoL. Conclusion: The results of this literature review demonstrate that PFMT is an effective treatment for UI in women. PFMT significantly improves the QoL of women with UI, which is an important determinant of their physical, mental, and social functioning. Keywords: urinary incontinence, pelvic floor muscle training, quality of life

Cortisol awakening response in drug-naïve panic disorder

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Jakuszkowiak-Wojten K

2016-06-01

Full Text Available Katarzyna Jakuszkowiak-Wojten, Jerzy Landowski, Mariusz S Wiglusz, Wiesław Jerzy Cubała Department of Psychiatry, Medical University of Gdansk, Gdansk, Poland Background: It is unclear whether hypothalamic–pituitary–adrenal axis is involved in the pathophysiology of panic disorder (PD. The findings remain inconsistent. Cortisol awakening response (CAR is a noninvasive biomarker of stress system activity. We designed the study to assess CAR in drug-naïve PD patients.   Materials and methods: We assessed CAR in 14 psychotropic drug-naïve outpatients with PD and 14 healthy controls. The severity of PD was assessed with Panic and Agoraphobia Scale. The severity of anxiety and depression was screened with Hospital Anxiety and Depression Scale.   Results: No significant difference in CAR between PD patients and control group was found. No correlations were observed between CAR and anxiety severity measures in PD patients and controls.   Limitations: The number of participating subjects was relatively small, and the study results apply to nonsuicidal drug-naïve PD patients without agoraphobia and with short-illness duration. There was a lack of control on subjects’ compliance with the sampling instructions.  Conclusion: The study provides no support for elevated CAR levels in drug-naïve PD patients without agoraphobia. Keywords: panic disorder, PD, CAR, cortisol awakening response, HPA axis, hypothalamic–pituitary–adrenal axis

Wstępna ocena ryzyka zawodowego fizjoterapeuty za pomocą metody SWP = Preliminary evaluation of occupational risk for physiotherapists using the SWP method

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Kinga Dorota Kulczycka

2016-09-01

  Wstępna ocena ryzyka zawodowego fizjoterapeuty za pomocą metody SWP Preliminary evaluation of occupational risk for physiotherapists using the SWP method   Kinga Kulczycka, Marcin Domagała, Ewa Stychno   Katedra i Zakład Zarządzania w  Pielęgniarstwie Wydział Nauk o  Zdrowiu Uniwersytet Medyczny w Lublinie Chair and Department of Management in Nursing Faculty Health Sciences Medical University of Lublin   Słowa kluczowe: Narażenie zawodowe, Fizjoterapeuci, Obciążenie pracą Key words: Occupational exposure, Physical therapists, Workload       Dr n. med. Kinga Kulczycka, mgr. Marcin Domagała, dr n.med. Ewa Stychno   Doctor of Medical Sciences Kinga Kulczycka, Holder of University Degree Marcin Domagała, Doctor of Medical Sciences Ewa Stychno     Streszczenie  Sposób wykonywania pracy, w warunkach znacznego obciążenia  ma wielkie znaczenie w profilaktyce zaburzeń układu mięśniowo-szkieletowego. Praca fizjoterapeutów często wiąże się z koniecznością przyjmowania niefizjologicznych  pozycji ciała, w trakcie których może dojść do urazów. Celem badania jest rozpoznanie pozycji ciała przyjmowanych przez fizjoterapeutów podczas pracy, które mogą stanowić  czynniki ryzyka związane ze  sposobem wykonywania pracy fizjoterapeuty. Materiał i metody  Badania przeprowadzono w 2014 r. z udziałem 100 fizjoterapeutów pracujących na oddziałach rehabilitacji, na terenie województwa Świętokrzyskiego. Wyniki Respondenci oceniali jako niewłaściwe przyjmowane  pozycje ciała, które zaobserwowali podczas wykonywania czynności zawodowych związane są z  pochylaniem podczas wykonywania czynności,  zgięcie odcinka lędźwiowego kręgosłupa i częste rotacje. Jako dodatkowe obciążenia w pracy uważali zginanie głowy do przodu lub skręcenie karku. Ruchy ramion stanowią znaczną uciążliwość dla fizjoterapeutów i występują podczas podnoszenia rąk do przodu i przesuwaniu ich w kierunku klatki piersiowej

Elevated risk of venous thromboembolic events in patients with inflammatory myopathies

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Nowak M

2016-06-01

Full Text Available Michał Nowak, Katarzyna Królak-Nowak, Aleksandra Sobolewska-Włodarczyk, Jakub Fichna, Marcin Włodarczyk Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland Abstract: Venous thromboembolism (VTE is a multifactorial disease manifesting as either deep vein thrombosis or pulmonary embolism. Its prevalence makes VTE a significant issue for both the individual – as a negative factor influencing the quality of life and prognosis – and the society due to economic burden. VTE is the third most common vascular disorder in Western countries, after myocardial infarction and stroke, making it a major cause of in-hospital mortality, responsible for 5%–10% of hospital deaths. Despite many studies conducted, only 50%–60% provoking factors have been identified, while the remaining 40%–50% have been classified as idiopathic or unprovoked. Chronic inflammatory disorders, with their underlying prothrombotic state, reveal an increased risk of VTE (six to eight times compared with the general population. Among the inflammatory disorders, we can identify inflammatory myopathies – a group of rare, chronic diseases featuring weakness and inflammation of muscles with periods of exacerbation and remission; their main classes are polymyositis and dermatomyositis. The objective of this review is to emphasize the need of VTE prophylaxis in individuals with inflammatory myopathies in order to reduce morbidity and mortality rates among those patients and improve their quality of life and prognosis. Keywords: deep vein thrombosis, pulmonary embolism, inflammation, polymyositis, dermatomyositis, prothrombotic state

PREFACE: MicroTherm' 2013 - Microtechnology and Thermal Problems in Electronics

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Lisik, Zbigniew; Raj, Ewa

2014-04-01

MicroTherm is an International Conference on Microtechnology and Thermal Problems in Electronics organised as a cyclic event since 1996. The success of the first seminar, which was devoted mainly to thermal management aspects, and the successive conferences have led us to the tenth edition. Since the first meeting, the scope of the conference has expanded, following the progress of electronics. Now, it covers subjects connected with extreme temperature, electronics, sensors and measurement techniques, modelling, simulation, wide band-gap materials, packaging and reliability, renewable energy sources and photonics with special emphasis on microelectronic technologies. MicroTherm' 2013 was held in Lodz, Poland, on 25-28 June 2013. The programme consistied of invited talks and nine regular sessions in the form of planar discussions and poster presentations, including a Students' Session. The Students' session gave an opportunity for students and young researchers to present their first achievements in the field of science. The next MicroTherm Conference is going to be held on 22-25 June 2015, in Lodz — a beautiful, post-industrial city located in the centre of Poland. Please, feel invited to MicroTherm' 2015 (www.microtherm.dsod.pl). Ewa Raj and Zbigniew Lisik Editors

Entropy-Weighted Instance Matching Between Different Sourcing Points of Interest

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Lin Li

2016-01-01

Full Text Available The crucial problem for integrating geospatial data is finding the corresponding objects (the counterpart from different sources. Most current studies focus on object matching with individual attributes such as spatial, name, or other attributes, which avoids the difficulty of integrating those attributes, but at the cost of an ineffective matching. In this study, we propose an approach for matching instances by integrating heterogeneous attributes with the allocation of suitable attribute weights via information entropy. First, a normalized similarity formula is developed, which can simplify the calculation of spatial attribute similarity. Second, sound-based and word segmentation-based methods are adopted to eliminate the semantic ambiguity when there is a lack of a normative coding standard in geospatial data to express the name attribute. Third, category mapping is established to address the heterogeneity among different classifications. Finally, to address the non-linear characteristic of attribute similarity, the weights of the attributes are calculated by the entropy of the attributes. Experiments demonstrate that the Entropy-Weighted Approach (EWA has good performance both in terms of precision and recall for instance matching from different data sets.

Heavy physical work under time pressure: the garbage collection service--a case study.

Science.gov (United States)

Camada, Ilza Mitsuko de Oliveira; Pataro, Silvana Maria Santos; Fernandes, Rita de Cássia Pereira

2012-01-01

The increased generation of garbage has become a problem in large cities, with greater demand for collection services. The collector is subjected to high workload. This study describes the work in garbage collection service, highlighting the requirements of time, resulting in physical and psychosocial demands to collectors. Ergonomic Work Analysis (EWA) - a method focused on the study of work in real situations was used. Initially, technical visits, global observations and unstructured interviews with different subjects of a garbage collection company were conducted. The following step of the systematic observations was accompanied by interviews conducted during the execution of tasks, inquiring about the actions taken, and also interviews about the actions, but conducted after the development of the tasks, photographic records and audiovisual recordings, of workers from two garbage collection teams. Contradictions between the prescribed work and activities (actual work) were identified, as well as the variability present in this process, and strategies adopted by these workers to regulate the workload. It was concluded that the insufficiency of means and the organizational structure of management ensue a situation where the collection process is maintained at the expense of hyper-requesting these workers, both physically and psychosocially.

Working aspects and musculoskeletal disorders of workers in a school’s lactary

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Maria do Carmo Baracho de Alencar

2017-03-01

Full Text Available Objective: To investigate the working conditions and the occurrence of musculoskeletal disorders in cooks from a Primary Public School. Method: This is an ergonomic study and a case study. General data about the school and the workplace were surveyed. A questionnaire was applied to cooks to collect information on personal and work aspects and musculoskeletal symptoms. Tasks and work processes, systematic observations and records of work activities were noted in paper, as based on the methodological approach of Ergonomic Work Analysis (EWA. Results: Two cooks participated in the study. They were 43 and 49 years old. They reported musculoskeletal symptoms in the region of wrist, hands, and low back in the last 12 months; and in the cervical and low back in the last seven days. Several inappropriate working conditions were found, including some related to the physical space and thermal environment, as well as aspects of work organization (undersized team, time for delivery of foods, etc.. Conclusion: Precarious working conditions tend to favor the emergence and/or worsening of musculoskeletal disorders in cooks of Primary Public Schools, and further research aimed at prevention and health promotion are necessary

ERGONOMIC WORK ANALYSIS APPLICATION IN A SMALL SHOE BUSINESS

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Aline Marian Callegaro

2013-11-01

Full Text Available This paper aims to presentthe results after conducting an Ergonomic Work Analysis (EWA in a smallbusiness located in Porto Alegre. The ergonomic intervention was performed basedon Guérin et al. (2001 and aimed to analyze the process organization and thelayout of the shoemaker workstations to provide improvements to these areas.The starting point was the account of the small shoe business owner’s need hadto hire one more shoemaker without increasing the company physical space. The EWAwas used focusing the work organization, how the flow of information ran fromthe entry of an order to the final stage of the product repairing. Thediagnosis showed the company main problems were related to the shop assistantsdependence on the shoemakers to provide budget information and delivery time tocustomers and the layout organization. Among the results, a temporal analysisof two company recurrent tasks was performed in order to ascertain possiblelosses related to the displacement and the search for material. A new layoutscheme was also proposed, aiming to organize the work stations, making easierthe stock, tools and equipment removal, providing a free space to make possiblethe hiring of the new shoemakers within the current company boundaries.

Fractionation of hairless canary seed (Phalaris canariensis) into starch, protein, and oil.

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Abdel-Aal, El-Sayed M; Hucl, Pierre; Patterson, Carol Ann; Gray, Danielle

2010-06-09

Canary seed is an important specialty crop in Canada. The current market for this true cereal (i.e., belonging to the family Poaceae as wheat) is limited to feed for caged birds. However, canary seed holds a promise for many food and industrial applications based on its composition. Three wet milling procedures based on ethanol (E), water (W), and alkaline (A) extractions used in different order were investigated to determine extraction efficiency and purity of starch, protein, oil, and fiber separated from hairless canary seed, a variety developed for human consumption. Highest extraction efficiencies were obtained when canary seed was defatted with ethanol and then extracted with alkali and water (EAW process). Using this process, approximately 92% pure starch, 75% pure protein, and oil were recovered from canary seed groats. The highest purity of protein, however, was obtained when canary seed was fractionated by the EWA process, that is, defatted and then extracted with water followed by alkali. Fiber component separated prior to alkaline extraction contained high amounts of nonfiber components as indicated by its yield. The EAW extraction process seems to be more promising in canary seed fractionation based on recovery and purity of components.

Ergonomic activity analysis of the musicians of the Symphony Orchestra of Paraná state: risk factors and workloads

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Jaqueline de Lima

2014-04-01

Full Text Available This study aimed to investigate the risk factors present in the work activity and their impact on the health of the musicians of the Symphony Orchestra of Parana state. It is a descriptive qualitative research based on the method of Ergonomic Workplace Analysis of Francophone strand, used as a tool by occupational therapists in the health-work interface. The following procedures were performed: bibliographical survey, documental analysis of productivity data, production and quality of the task, systematic observation of the rehearsals of the Symphony Orchestra of Parana, task and workplace analysis with the application of Ergonomic Workplace Analysis (EWA and, confrontation of the data analyzed with an instrumental musician. As a result, the study showed significant deviations with reference to the standards described in Brazilian Norm 17 (Ergonomics, especially regarding individual cognitive and physical demands as well as demands related to work organization, considering each item evaluated by this analytical instrument. The action of occupational therapy was grounded on the insertion in the health and illness process, health promotion, illness prevention, and training of musicians as workers and social actors, envisioning the transformation of work situations.

The Role of Field Classes in Education of Prospective Teachers in Biology

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E. Fleszar

2009-12-01

Full Text Available Field classes are indispensable in education of biology and environment protection students, as they allow a future teacher to carry out teaching material bringing together theory and practice through activity. In the framework of Biology Didactics classes the biology students of the Faculty of Natural Sciences at the University of Szczecin participate actively in the works on didactic nature trail in the Arkoñski Woods prepared by Dr. Ewa Fleszar. During the work on didactic natural path the students make themselves acquainted with: field class objectives; field class tasks; field class programmes, e.g. concerning phenology; flora and fauna species. Writing synopsis of field classes for selected lesson units at different teaching levels they acquire sound knowledge based on the ecological contents. Contacts with nature as well as gaining the experience during field classes allow them to obtain competences for working in the field and to understand the objectives of carrying out such classes. Field classes have an effect on developing interests of participants in the subject, and affect the improvement of teaching performance. Visit to the field forms ecological awareness, which leads to obtaining an ecological culture.

Cloud amount/frequency, NITRATE and other data from EWA, BORA and other platforms from 1928-08-16 to 1985-12-17 (NODC Accession 9300135)

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National Oceanic and Atmospheric Administration, Department of Commerce — The Ocean Serial data in this accession was collected by Poland as part of Global Ocean Data Archeaology and Rescue (GODAR) project using over 14 ships. The data was...

Ergonomics and risk management in high risk organizations: nuclear power plant operator decision making; A ergonomia e a gestao de risco em organizacoes que lidam com tecnologias perigosas: tomada de decisao de operadores de usinas nucleares

Energy Technology Data Exchange (ETDEWEB)

Carvalho, Paulo Victor Rodrigues de

2003-08-15

Nuclear power plants are high hazard environments where emergency situations can have devastating effects. The operator crew has the ultimate responsibility to control the energy production process with safety. The outcome of a crisis is consequently dependent on the crew's judgement, decision making and situation awareness. In such way we should know how operators make their decisions in order to develop safety strategies. The aim of this thesis is to examine the cognitive processes through which operators make decisions when dealing with micro incidents during their actual work, and to determine whether they use a naturalistic or normative decision making strategy. That is, do they try to recognize the micro incident as familiar and base decisions on condition-action rules (naturalistic), or do they need to concurrently compare and contrast options before selecting the best possible (normative). The method employed for data collection was the Cognitive Task Analysis (CTA) and Ergonomic Work Analysis (EWA). The main findings of this thesis were that decision making is primarily based on naturalistic strategies, such as condition-action rules and recognition. In new situations rules are created ad hoc. These rules appear derived from experience and training rather than from Standard Operating Procedures and contrast normative competence standards used by nuclear industry. (author)

Epigenetics and cerebral organoids: promising directions in autism spectrum disorders.

Science.gov (United States)

Forsberg, Sheena Louise; Ilieva, Mirolyuba; Maria Michel, Tanja

2018-01-10

Autism spectrum disorders (ASD) affect 1 in 68 children in the US according to the Centers for Disease Control and Prevention (CDC). It is characterized by impairments in social interactions and communication, restrictive and repetitive patterns of behaviors, and interests. Owing to disease complexity, only a limited number of treatment options are available mainly for children that alleviate but do not cure the debilitating symptoms. Studies confirm a genetic link, but environmental factors, such as medications, toxins, and maternal infection during pregnancy, as well as birth complications also play a role. Some studies indicate a set of candidate genes with different DNA methylation profiles in ASD compared to healthy individuals. Thus epigenetic alterations could help bridging the gene-environment gap in deciphering the underlying neurobiology of autism. However, epigenome-wide association studies (EWAS) have mainly included a very limited number of postmortem brain samples. Hence, cellular models mimicking brain development in vitro will be of great importance to study the critical epigenetic alterations and when they might happen. This review will give an overview of the state of the art concerning knowledge on epigenetic changes in autism and how new, cutting edge expertise based on three-dimensional (3D) stem cell technology models (brain organoids) can contribute in elucidating the multiple aspects of disease mechanisms.

Ergonomics and risk management in high risk organizations: nuclear power plant operator decision making

International Nuclear Information System (INIS)

Carvalho, Paulo Victor Rodrigues de

2003-08-01

Nuclear power plants are high hazard environments where emergency situations can have devastating effects. The operator crew has the ultimate responsibility to control the energy production process with safety. The outcome of a crisis is consequently dependent on the crew's judgement, decision making and situation awareness. In such way we should know how operators make their decisions in order to develop safety strategies. The aim of this thesis is to examine the cognitive processes through which operators make decisions when dealing with micro incidents during their actual work, and to determine whether they use a naturalistic or normative decision making strategy. That is, do they try to recognize the micro incident as familiar and base decisions on condition-action rules (naturalistic), or do they need to concurrently compare and contrast options before selecting the best possible (normative). The method employed for data collection was the Cognitive Task Analysis (CTA) and Ergonomic Work Analysis (EWA). The main findings of this thesis were that decision making is primarily based on naturalistic strategies, such as condition-action rules and recognition. In new situations rules are created ad hoc. These rules appear derived from experience and training rather than from Standard Operating Procedures and contrast normative competence standards used by nuclear industry. (author)

Determination of copper in biological materials by neutron activation analysis using short-lived 66Cu

International Nuclear Information System (INIS)

Dybczynski, R.; Danko, B.; Kaczorowski, J.

1989-01-01

A method for determination of copper traces in biological materials based on neutron activation employing 65 Cu(n, γ) 66 Cu reaction and preconcentration by extraction chromatography has been devised. The 200-500 mg samples after wet digestion and evaporation were dissolved in glycine solution and after pH adjusting to ca. 4.4 were passed through the column with Lix 64N on Bio Beads SM-1 for isolation of copper traces from the matrix elements. Other cations were selectively eluted with 0.1 mol x 1 -1 (glycine-HNO 3 ) buffer, 1 mol x 1 -1 in NH 4 NO 3 (pH = 3.6). The resin bed with quantitatively retained copper was sealed in the PE bag and irradiated together with Cu standards in EWA reactor using pneumatic tube facility. The activity of the short-lived 66 Cu was measured in samples and standard by gamma-ray spectrometry with Ge(Li) detector. Good accuracy of the method was confirmed by analysis of the following certified reference materials: NBS 1571 Orchad leaves, IAEA H-4 Animal muscle, IAEA V-8 Rye flour, IAEA A-11 milk powder. The detection limit amounted to 0.34 mg/kg, for the sample weight of 500 mg. (author)

Introducing RiskSOAP to communicate the distributed situation awareness of a system about safety issues: an application to a robotic system.

Science.gov (United States)

Chatzimichailidou, Maria Mikela; Dokas, Ioannis M

2016-03-01

This paper introduces the RiskSOAP ('RiskSOAP' is the abbreviation for Risk SituatiOn Awareness Provision.) indicator to measure the capability of a complex socio-technical system to provide its agents with situation awareness (SA) about the presence of its threats and vulnerabilities and enables analysts to assess distributed SA. The RiskSOAP methodology adopts a comparative approach between two design versions of a system differing in the elements and characteristics that can enhance or cause the degradation of the awareness provision capability. The methodology uniquely combines three methods: (1) the STPA hazard analysis, (2) the EWaSAP early warning sign identification approach, and (3) a dissimilarity measure for calculating the distance between binary sets. In this paper, the RiskSOAP methodology was applied to a robotic system and the findings show that the indicator is an objective measure for the system's capability to provide its agents with SA about its threats and vulnerabilities. Practitioner Summary: This paper suggests a novel methodology for assessing distributed situation awareness (DSA) regarding safety issues. Given that systems consist of specifications and components possible to be mapped, the risk SA provision capability (RiskSOAP) methodology demonstrates the feasibility of measuring to what extent systems' elements contribute to the emergence of DSA.

Ergophthalmology in accounting offices: the computer vision syndrome (CVS

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Arjuna Nudi Perin

Full Text Available Abstract Purpose: This study aimed to determine the presence of the symptoms of computer vision syndrome (CVS accounting office employees. Methods: The research tools used were a questionnaire based on the set of symptoms of CVS rated by Likert scale (1-5 and workplace observations based on Ergonomic Workplace Analysis (EWA. Results: The participants who worked with a viewing angle of less than 10º relative to the screen had more symptoms, particularly of pain in the back of the neck and back (p = 0.0460. The participants who used lighting other than 450 and 699 lux reported significant headache (p = 0.0045 and dry eye (p = 0.0329 symptoms. Younger workers had more headaches (p = 0.0182, and workers with fewer years of employment had more headaches and dry eyes symptoms (p = 0.0164 and p = 0.0479, respectively. A total of 37% of the participants reported a lack of guidance regarding prevention and painful symptoms in the back of the neck and back (p = 0.0936. Conclusion: Younger participants with fewer years of employment, who had not received information regarding proper computer use, who did not use lighting between 450 and 699 lux or who worked with viewing angles of less than 10º had more computer vision syndrome symptoms.

High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation.

Science.gov (United States)

Kesselmeier, Miriam; Pütter, Carolin; Volckmar, Anna-Lena; Baurecht, Hansjörg; Grallert, Harald; Illig, Thomas; Ismail, Khadeeja; Ollikainen, Miina; Silén, Yasmina; Keski-Rahkonen, Anna; Bulik, Cynthia M; Collier, David A; Zeggini, Eleftheria; Hebebrand, Johannes; Scherag, André; Hinney, Anke

2018-04-01

Patients with anorexia nervosa (AN) are ideally suited to identify differentially methylated genes in response to starvation. We examined high-throughput DNA methylation derived from whole blood of 47 females with AN, 47 lean females without AN and 100 population-based females to compare AN with both controls. To account for different cell type compositions, we applied two reference-free methods (FastLMM-EWASher, RefFreeEWAS) and searched for consensus CpG sites identified by both methods. We used a validation sample of five monozygotic AN-discordant twin pairs. Fifty-one consensus sites were identified in AN vs. lean and 81 in AN vs. population-based comparisons. These sites have not been reported in AN methylation analyses, but for the latter comparison 54/81 sites showed directionally consistent differential methylation effects in the AN-discordant twins. For a single nucleotide polymorphism rs923768 in CSGALNACT1 a nearby site was nominally associated with AN. At the gene level, we confirmed hypermethylated sites at TNXB. We found support for a locus at NR1H3 in the AN vs. lean control comparison, but the methylation direction was opposite to the one previously reported. We confirm genes like TNXB previously described to comprise differentially methylated sites, and highlight further sites that might be specifically involved in AN starvation processes.

Epigenome-Wide Association Study of Tic Disorders.

Science.gov (United States)

Zilhão, Nuno R; Padmanabhuni, Shanmukha S; Pagliaroli, Luca; Barta, Csaba; Smit, Dirk J A; Cath, Danielle; Nivard, Michel G; Baselmans, Bart M L; van Dongen, Jenny; Paschou, Peristera; Boomsma, Dorret I

2015-12-01

Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10-(15)) developmental process (GO:0032502, p = 2.96 × 10(-12)), and cellular developmental process (GO:0048869, p = 1.96 × 10(-12)). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

Personalized skincare: from molecular basis to clinical and commercial applications

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Markiewicz E

2018-04-01

Full Text Available Ewa Markiewicz, Olusola Clement Idowu Research & Development, Hexis Lab, Science Central, The Core, Bath Lane, Newcastle upon Tyne, UK Abstract: Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects. The unique characteristics of the individual skin function and, particularly, of the ethnic skin type are currently considered to shape the future of clinical and pharmacologic interventions as a basis for personalized skincare. Individual approaches to skincare render a novel and actively growing area with a range of biomedical and commercial applications within cosmetics industry. In this review, we summarize the aspects of the molecular and clinical manifestations of the environmental stress on human skin and proposed protective mechanisms that are linked to ethnic differences and pathophysiology of extrinsic skin aging. We subsequently discuss the possible applications and translation of this knowledge into personalized skincare. Keywords: pigmentation, gene polymorphism, photodamage, environmental stress, cosmetics

Materials from seminar session of the 3.general assembly of Polish Nuclear Society; 3.Walny Zjazd Polskiego Towarzystwa Nukleonicznego. Materialy sesji seminaryjnej

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-31

This publication edited as a scientific report of the Institute of Atomic Energy contains papers presented on the seminar session accompanying the 3rd General Assembly of Polish Nuclear Society. Five of these are dealing with the present situation in Poland in the framework of the following subjects: foreseeing electricity demand as a significant factor of development of electricity generation sector and nuclear option choice; present state and development trends of nuclear technique applications in industry, agriculture, health and environment protection; radioactive waste management especially related to the storage of spent fuel from EWA and MARIA research reactors; present educational problems in nuclear science and technology. The problems of nuclear power could not be excluded from the session, although it does not exist in Poland and no plans foresee it currently. The paper on nuclear power contains an extensive summary of nuclear power development worldwide, its safety problems, economic competitiveness and public acceptance. The so called ``Sellafield phenomenon`` considering the growth of leukaemia deaths of children living near that reprocessing plant in England has been commented in mass media criticizing nuclear energy application. The paper on this problem present the results of investigations and hypotheses on reasons having caused this phenomenon. The declaration of the International Council of Nuclear Societies on the role of nuclear science and technology in supporting the development is also included in the report.

Can stormwater be detected by algae in an urban reef in Hawai‘i?

International Nuclear Information System (INIS)

Erin Cox, T.; Smith, Celia M.; Popp, Brian N.; Foster, Michael S.; Abbott, Isabella A.

2013-01-01

Highlights: • Invasive and native algae are a part of a reef assemblage located in an urban area. • Algal nitrogen (N) composition tested if N was enriched from storm-drain outlets. • Elevated N values indicated a mixed, high nutrient environment. • Storm-drains as plausible nitrogenous source was not supported. • Temporal and spatial values indicate algae incorporated terrestrial derived N. -- Abstract: Nitrogen (N) enrichment of tropical reefs can result in the dominance of invasive algae. The invasive alga Acanthophora spicifera and the native alga Laurencia nidifica are part of a diverse reef assemblage in ‘Ewa Beach, O‘ahu. Their N contents and δ 15 N values were investigated to determine if N was enriched and to evaluate potential nitrogenous sources near and removed from storm-drain outlets. δ 15 N values of algae (3.8–17.7‰) were within and above the range for algae around the island (1.9–11.9‰). Elevated algae N isotope values (δ 15 N > +7‰, [N] > 1.6%) and seawater nitrate + nitrite levels (0.59–7.93 μM) indicated a mixed, high nutrient environment. The overlap in δ 15 N values with multiple nitrogenous sources precluded identification. However, spatial and temporal patterns did not support stormwater as the dominant, nitrogenous source. Patterns were congruent with algal incorporation of terrestrial derived N, subjected to a high degree of biogeochemical cycling

Toward a panoramic perspective of the association between environmental factors and cardiovascular disease: An environment-wide association study from National Health and Nutrition Examination Survey 1999-2014.

Science.gov (United States)

Zhuang, Xiaodong; Guo, Yue; Ni, Ao; Yang, Daya; Liao, Lizhen; Zhang, Shaozhao; Zhou, Huimin; Sun, Xiuting; Wang, Lichun; Wang, Xueqin; Liao, Xinxue

2018-06-04

An environment-wide association study (EWAS) may be useful to comprehensively test and validate associations between environmental factors and cardiovascular disease (CVD) in an unbiased manner. Data from National Health and Nutrition Examination Survey (1999-2014) were randomly 50:50 spilt into training set and testing set. CVD was ascertained by a self-reported diagnosis of myocardial infarction, coronary heart disease or stroke. We performed multiple linear regression analyses associating 203 environmental factors and 132 clinical phenotypes with CVD in training set (false discovery rate multicollinearity elimination and variable importance ranking. Discriminative power of factors for CVD was calculated by area under the receiver operating characteristic (AUROC). Overall, 43,568 participants with 4084 (9.4%) CVD were included. After adjusting for age, sex, race, body mass index, blood pressure and socio-economic level, we identified 5 environmental variables and 19 clinical phenotypes associated with CVD in training and testing dataset. Top five factors in RF importance ranking were: waist, glucose, uric acid, and red cell distribution width and glycated hemoglobin. AUROC of the RF model was 0.816 (top 5 factors) and 0.819 (full model). Sensitivity analyses reveal no specific moderators of the associations. Our systematic evaluation provides new knowledge on the complex array of environmental correlates of CVD. These identified correlates may serve as a complementary approach to CVD risk assessment. Our findings need to be probed in further observational and interventional studies. Copyright © 2018. Published by Elsevier Ltd.

Comparison of the effectiveness of complex decongestive therapy and compression bandaging as a method of treatment of lymphedema in the elderly

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Zasadzka E

2018-05-01

Full Text Available Ewa Zasadzka,1 Tomasz Trzmiel,1 Maria Kleczewska,2 Mariola Pawlaczyk1 1Department of Geriatric Medicine and Gerontology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland; 2Day Rehabilitation Center, Hospicjum Palium, Poznań, Poland Background: Lymphedema is a chronic condition which significantly lowers the quality of patient life, particularly among elderly populations, whose mobility and physical function are often reduced. Objectives: The aim of the study was to compare the effectiveness of multi-layer compression bandaging (MCB and complex decongestive therapy (CDT, and to show that MCB is a cheaper, more accessible and less labor intensive method of treating lymphedema in elderly patients. Patients and methods: The study included 103 patients (85 women and 18 men aged ≥60 years, with unilateral lower limb lymphedema. The subjects were divided into two groups: 50 treated with CDT and 53 with MCB. Pre- and post-treatment BMI, and average and maximum circumference of the edematous extremities were analyzed. Results: Reduction in swelling in both groups was achieved after 15 interventions. Both therapies demonstrated similar efficacy in reducing limb volume and circumference, but MCB showed greater efficacy in reducing the maximum circumference. Conclusion: Compression bandaging is a vital component of CDT. Maximum lymphedema reduction during therapy and maintaining its effect cannot be achieved without it. It also demonstrates its effectiveness as an independent method, which can reduce therapy cost and accessibility. Keywords: lymphedema, elderly, therapy, compression bandaging

Tobacco smoking leads to extensive genome-wide changes in DNA methylation.

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Sonja Zeilinger

Full Text Available Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases. We conducted an epigenome-wide association study (EWAs comparing current, former and never smokers from 1793 participants of the population-based KORA F4 panel, with replication in 479 participants from the KORA F3 panel, carried out by the 450K BeadChip with genomic DNA obtained from whole blood. We observed wide-spread differences in the degree of site-specific methylation (with p-values ranging from 9.31E-08 to 2.54E-182 as a function of tobacco smoking in each of the 22 autosomes, with the percent of variance explained by smoking ranging from 1.31 to 41.02. Depending on cessation time and pack-years, methylation levels in former smokers were found to be close to the ones seen in never smokers. In addition, methylation-specific protein binding patterns were observed for cg05575921 within AHRR, which had the highest level of detectable changes in DNA methylation associated with tobacco smoking (-24.40% methylation; p = 2.54E-182, suggesting a regulatory role for gene expression. The results of our study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers.

Tobacco smoking leads to extensive genome-wide changes in DNA methylation.

Science.gov (United States)

Zeilinger, Sonja; Kühnel, Brigitte; Klopp, Norman; Baurecht, Hansjörg; Kleinschmidt, Anja; Gieger, Christian; Weidinger, Stephan; Lattka, Eva; Adamski, Jerzy; Peters, Annette; Strauch, Konstantin; Waldenberger, Melanie; Illig, Thomas

2013-01-01

Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases. We conducted an epigenome-wide association study (EWAs) comparing current, former and never smokers from 1793 participants of the population-based KORA F4 panel, with replication in 479 participants from the KORA F3 panel, carried out by the 450K BeadChip with genomic DNA obtained from whole blood. We observed wide-spread differences in the degree of site-specific methylation (with p-values ranging from 9.31E-08 to 2.54E-182) as a function of tobacco smoking in each of the 22 autosomes, with the percent of variance explained by smoking ranging from 1.31 to 41.02. Depending on cessation time and pack-years, methylation levels in former smokers were found to be close to the ones seen in never smokers. In addition, methylation-specific protein binding patterns were observed for cg05575921 within AHRR, which had the highest level of detectable changes in DNA methylation associated with tobacco smoking (-24.40% methylation; p = 2.54E-182), suggesting a regulatory role for gene expression. The results of our study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers.

Generation, Transformation and Place in Inga Iwasiów’s Novels Bambino (2008 and Ku słońcu (2010

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Ursula PHILLIPS

2012-06-01

Full Text Available This chapter will discuss two novels by contemporary writer Inga Iwasiów (b. 1963, Bambino (2008 and Ku słońcu [Towards the Sun] (2010, in the context of geopolitical, ideological, social and psycho-cultural transformations as they specifically affect different generations of inhabitants of the Polish city of Szczecin (pre-1945 German Stettin from 1945 until the first decade of the 21st century. Bambino covers the years 1945–1981, but also contains flashbacksto pre-war memory of Stettin and to the suppressed experiences of the new post-war inhabitants, as well as ‘flash-forwards’ to post-1989, post-communist reality; Ku słońcu covers 1981 to the first decade of 2000s. It will show how the novels portray these transformations through the experience primarily of women (but not only — in Bambino, through the main protagonists: Ula (formerly Ulrike, Anna and Marysia, and through that of the hidden narrator Magda (Marysia’s daughter born in the same year as the author, Iwasiów, 1963; and in Ku słońcu, primarily through the experience of Magda herself, as well as through that of two generations of ‘feminist’ academics: Małgorzata and Sylwia (in which it is hard not to perceive the personal experience of the author, though she is at pains to emphasize elsewhere that her work is a collective biography of the city, not so much of herself. The analysis follows Katarzyna Chmielewska’s supposition that contemporary Polish fiction dealing with the past ‘constantly oscillates between memory and genealogy’, and that it raises raw issues not yet addressed by historians; it also derives inspiration from the new ‘postdependency’ studiesproposed by Hanna Gosk and Ryszard Nycz. It also attempts to capture the specific nature of Iwasiów’s use of language, her style of feminism, her method of portraying place, and the connections in her prose between place and memory.

Analgesic efficacy, adverse effects, and safety of oxycodone administered as continuous intravenous infusion in patients after total hip arthroplasty

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Olczak B

2017-05-01

Full Text Available Bogumił Olczak,1 Grzegorz Kowalski,1,2 Wojciech Leppert,2 Iwona Zaporowska-Stachowiak,3 Katarzyna Wieczorowska-Tobis2 1Department of Anesthesiology, Józef Struś Multiprofile Municipal Hospital, 2Department of Palliative Medicine, Poznan University of Medical Sciences, 3Department of Pharmacology, Poznan University of Medical Sciences, Poland Background: Total hip arthroplasty (THA causes extensive tissue damage and severe pain. This study aimed to assess the analgesic efficacy, adverse effects (AEs, and safety of continuous intravenous (iv oxycodone infusion with ketoprofen (injected into the iv line in patients after THA, and to assay serum oxycodone levels.Patients and methods: Fourteen patients, aged 59‒82 years with American Society of Anesthesiologists (ASA classification I or III, underwent THA with intrathecal analgesia and sedation induced by iv propofol. After the surgery, oxycodone (continuous iv infusion at a dose of 1 mg/h (five patients or 2 mg/h (nine patients with 100 mg ketoprofen (injected into the iv line was administered to each patient every 12 h. Pain was assessed using a numerical rating scale (NRS: 0 – no pain, 10 – the most severe pain at rest and during movement. AEs, including hemodynamic unsteadiness, nausea, vomiting, pruritus, cognitive impairment, and respiratory depression, were registered during the first 24 h after surgery.Results: Oxycodone (continuous iv infusion at a dose of 2 mg/h with ketoprofen (100 mg administered every 12 h provided satisfactory analgesia in all nine patients without the need of rescue analgesics within the first 24 h after THA. In three out of five patients, oxycodone at 1 mg/h was effective. Oxycodone did not induce drowsiness, vomiting, pruritus, respiratory depression, or changes in blood pressure. Bradycardia appeared in two patients, and nausea was observed in one patient.Conclusion: Oxycodone infusion with ketoprofen administered by iv is effective in patients after THA

Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study

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Olczak B

2017-09-01

Full Text Available Bogumił Olczak,1 Grzegorz Kowalski,1,2 Wojciech Leppert,2 Agnieszka Bienert,3 Artur Teżyk,4 Michał Adamski,1 Stanisław Rzymski,1 Katarzyna Wieczorowska-Tobis2 1Department of Anaesthesiology, Józef Struś Multiprofile Municipal Hospital, Poznań, 2Department of Palliative Medicine, 3Department of Clinical Pharmacy and Biopharmacy, 4Department of Forensic Medicine, Poznan University of Medical Sciences, Poznań, Poland Background and objectives: Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was to assess the efficacy and safety of oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA.Patients and methods: In 11 patients (American Society of Anesthesiologists physical status classification system II/III, age range: 59–82 years, THA was conducted with an epidural blockade using 15 mL 0.25% bupivacaine (37.5 mg with 5 mg oxycodone hydrochloride and sedation with propofol infusion at a dose of 3–5 mg/kg/h. After the surgery, patients received ketoprofen at a dose of 100 mg twice daily. In the first 24 hours postoperative period, pain was assessed by numerical rating scale at rest and on movement; adverse effects (AEs were recorded; and plasma concentrations of oxycodone, noroxycodone, and bupivacaine were measured.Results: The administration of epidural oxycodone at a dose of 5 mg in patients undergoing THA provided analgesia for a mean time of 10.3±4.89 h. In one patient, mild pruritus was observed. Oxycodone did not evoke other AEs. Plasma concentrations of oxycodone while preserving analgesia were >2.9 ng/mL. Noroxycodone concentrations in plasma did not guarantee analgesic effect.Conclusion: The administration of epidural oxycodone at a dose of 5 mg prolongs the analgesia period to ~10 hours in patients after THA. Oxycodone may evoke pruritus. A 5 mg dose of oxycodone hydrochloride used in an epidural blockade seems to be a safe drug in patients

Poronienie i ciąża obumarła w aspekcie prawa – udział położnej w opiece nad pacjentką w sytuacji utraty ciąży = Miscarriage and pregnancy degenerated in terms of law - part midwife in the care of the patient in case of pregnancy loss

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Sabina Katarzyna Stadnicka

2016-09-01

  Sabina Katarzyna Stadnicka, mgr położnictwa, doktorantka, Katedra i Zakład Pielęgniarstwa Pediatrycznego, Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie Agnieszka Bień, dr n. med., adiunkt, Zakład Podstaw Położnictwa, Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie Paulina Gdańska, mgr psychologii, I Katedra i Klinika Położnictwa i Ginekologii Warszawskiego Uniwersytetu Medycznego Joanna Piechowska, mgr położnictwa, doktorantka, Zakład Podstaw Położnictwa, Wydział Nauk o Zdrowiu Uniwersytetu Medycznego w Lublinie         Streszczenie Niekorzystne zakończenie ciąży ma charakter niezwykle złożony i delikatny. Utrata ciąży na skutek poronienia jest wydarzeniem biomedycznym wywierającym ogromny wpływ na funkcjonowanie psychiczne. Nowe Rozporządzenie Ministra Zdrowia z dnia 1 grudnia 2015r. wprowadza dokładnie określone standardy postępowań okołoporodowych w opiece nad pacjentkami w sytuacji niepowodzeń położniczych. Celem publikacji jest pokazanie istotności wprowadzenia standardów. Odpowiedni przekaz niepomyślnych wiadomości, poprawna komunikacja a także udzielenie wsparcia może załagodzić psychologiczne skutki niepomyślnej sytuacji. Słowa kluczowe: ciąża, poronienie, strata, przepisy prawa, zdrowie psychiczne     Abstract Unfavorable termination of pregnancy is a very complex and delicate. Pregnancy loss due to miscarriage is an event biomedical exerting a huge influence on the functioning of mental health. The new Minister of Health of 1 December 2015. introduces precisely defined standards proceedings perinatal care for female patients in an obstetric failures. The aim of the publication is to show the significance of the introduction of standards. The corresponding message bad news, the correct communication and assistance can alleviate the psychological effects of unfavorable situation. Key words: pregnancy, miscarriage, loss, law, mental health

A method to associate all possible combinations of genetic and environmental factors using GxE landscape plot.

Science.gov (United States)

Nagaie, Satoshi; Ogishima, Soichi; Nakaya, Jun; Tanaka, Hiroshi

2015-01-01

Genome-wide association studies (GWAS) and linkage analysis has identified many single nucleotide polymorphisms (SNPs) related to disease. There are many unknown SNPs whose minor allele frequencies (MAFs) as low as 0.005 having intermediate effects with odds ratio between 1.5~3.0. Low frequency variants having intermediate effects on disease pathogenesis are believed to have complex interactions with environmental factors called gene-environment interactions (GxE). Hence, we describe a model using 3D Manhattan plot called GxE landscape plot to visualize the association of p-values for gene-environment interactions (GxE). We used the Gene-Environment iNteraction Simulator 2 (GENS2) program to simulate interactions between two genetic loci and one environmental factor in this exercise. The dataset used for training contains disease status, gender, 20 environmental exposures and 100 genotypes for 170 subjects, and p-values were calculated by Cochran-Mantel-Haenszel chi-squared test on known data. Subsequently, we created a 3D GxE landscape plot of negative logarithm of the association of p-values for all the possible combinations of genetic and environmental factors with their hierarchical clustering. Thus, the GxE landscape plot is a valuable model to predict association of p-values for GxE and similarity among genotypes and environments in the context of disease pathogenesis. GxE - Gene-environment interactions, GWAS - Genome-wide association study, MAFs - Minor allele frequencies, SNPs - Single nucleotide polymorphisms, EWAS - Environment-wide association study, FDR - False discovery rate, JPT+CHB - HapMap population of Japanese in Tokyo, Japan - Han Chinese in Beijing.

Chemical exchange rotation transfer imaging of intermediate-exchanging amines at 2 ppm.

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Zu, Zhongliang; Louie, Elizabeth A; Lin, Eugene C; Jiang, Xiaoyu; Does, Mark D; Gore, John C; Gochberg, Daniel F

2017-10-01

Chemical exchange saturation transfer (CEST) imaging of amine protons exchanging at intermediate rates and whose chemical shift is around 2 ppm may provide a means of mapping creatine. However, the quantification of this effect may be compromised by the influence of overlapping CEST signals from fast-exchanging amines and hydroxyls. We aimed to investigate the exchange rate filtering effect of a variation of CEST, named chemical exchange rotation transfer (CERT), as a means of isolating creatine contributions at around 2 ppm from other overlapping signals. Simulations were performed to study the filtering effects of CERT for the selection of transfer effects from protons of specific exchange rates. Control samples containing the main metabolites in brain, bovine serum albumin (BSA) and egg white albumen (EWA) at their physiological concentrations and pH were used to study the ability of CERT to isolate molecules with amines at 2 ppm that exchange at intermediate rates, and corresponding methods were used for in vivo rat brain imaging. Simulations showed that exchange rate filtering can be combined with conventional filtering based on chemical shift. Studies on samples showed that signal contributions from creatine can be separated from those of other metabolites using this combined filter, but contributions from protein amines may still be significant. This exchange filtering can also be used for in vivo imaging. CERT provides more specific quantification of amines at 2 ppm that exchange at intermediate rates compared with conventional CEST imaging. Copyright © 2017 John Wiley & Sons, Ltd.

Education in wrist arthroscopy: past, present and future.

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Obdeijn, M C; Bavinck, N; Mathoulin, C; van der Horst, C M A M; Schijven, M P; Tuijthof, G J M

2015-05-01

Arthroscopy has assumed an important place in wrist surgery. It requires specific operative skills that are now mainly acquired in the operating room. In other fields of endoscopic surgery, e-learning and virtual reality (VR) have introduced new perspectives in teaching skills. This leads to the following research question: Could the current way of teaching wrist arthroscopy skills be supported using new educational media, such as e-learning and simulator training? The literature was searched for available methods of teaching endoscopic skills. Articles were assessed on the evidence of validity. In addition, a survey was sent to all members of the European Wrist Arthroscopy Society (EWAS) to find out whether hand surgeons express a need to embrace modern educational tools such as e-learning or simulators for training of wrist arthroscopy skills. This study shows that the current way of teaching wrist arthroscopy skills can be supported using new educational media, such as e-learning and simulator training. Literature indicates that e-learning can be a valuable tool for teaching basic knowledge of arthroscopy and supports the hypothesis that the use of virtual reality and simulators in training enhances operative skills in surgical trainees. This survey indicates that 55 out of 65 respondents feel that an e-learning program would be a valuable asset and 62 out of the 65 respondents are positive on the additional value of wrist arthroscopy simulator in training. Study results support the need and relevance to strengthen current training of wrist arthroscopy using e-learning and simulator training. V.

Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.

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Ulrike Esslinger

Full Text Available Dilated cardiomyopathy (DCM is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS to assess the contribution of missense variants to sporadic DCM.116,855 single nucleotide variants (SNVs were analyzed in 2796 DCM patients and 6877 control subjects from 6 populations of European ancestry. We confirmed two previously identified associations with SNVs in BAG3 and ZBTB17 and discovered six novel DCM-associated loci (Q-value<0.01. The lead-SNVs at novel loci are common and located in TTN, SLC39A8, MLIP, FLNC, ALPK3 and FHOD3. In silico fine mapping identified HSPB7 as the most likely candidate at the ZBTB17 locus. Rare variant analysis (MAF<0.01 demonstrated significant association for TTN variants only (P = 0.0085. All candidate genes but one (SLC39A8 exhibit preferential expression in striated muscle tissues and mutations in TTN, BAG3, FLNC and FHOD3 are known to cause familial cardiomyopathy. We also investigated a panel of 48 known cardiomyopathy genes. Collectively, rare (n = 228, P = 0.0033 or common (n = 36, P = 0.019 variants with elevated in silico severity scores were associated with DCM, indicating that the spectrum of genes contributing to sporadic DCM extends beyond those identified here.We identified eight loci independently associated with sporadic DCM. The functions of the best candidate genes at these loci suggest that proteostasis regulation might play a role in DCM pathophysiology.

Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following Porphyromonas gingivalis infection

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Meresta A

2017-01-01

Full Text Available Anna Meresta,1 Justyna Folkert,1 Timo Gaber,2 Korneliusz Miksch,1 Frank Buttgereit,2 Jacqueline Detert,2 Nicole Pischon,3,* Katarzyna Gurzawska3,4,* 1Environmental Biotechnology Department, Faculty of Power and Environmental, Silesian University of Technology, Gliwice, Poland; 2Department of Rheumatology and Clinical Immunology, 3Department of Periodontology, Charité University Medicine, Berlin, Germany; 4Oral Surgery Department, The School of Dentistry, University of Birmingham, Birmingham, UK *These authors contributed equally to this work Background: Bioengineered plant-derived Rhamnogalacturonan-Is (RG-Is from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following Porphyromonas gingivalis infection.Methods: Murine MC3T3-E1 osteoblasts and isolated primary calvarial osteoblasts from C57BL/6J (B6J osteoblasts mice were infected with P. gingivalis and incubated on tissue culture polystyrene plates with or without nanocoatings of unmodified RG-Is isolated from potato pulps (PU or dearabinanated RG-Is (PA. To investigate a behavior of infected osteoblasts cultured on RG-Is cell morphology, proliferation, metabolic activity, mineralization and osteogenic and pro-inflammatory gene expression were examined.Results: Following P. gingivalis infection, PA, but not PU, significantly promoted MC3T3-E1 and BJ6 osteoblasts proliferation, metabolic activity, and calcium deposition. Moreover, Il-1b, Il-6, TNF-α, and Rankl gene expressions were downregulated in cells cultured on PU and to a higher extent on PA as compared to the corresponding control, whereas Runx, Alpl, Col1a1, and Bglap gene expressions were upregulated vice

The evaluation of pharmaceutical pictograms among elderly patients in community pharmacy settings – a multicenter pilot study

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Merks P

2018-02-01

Full Text Available Piotr Merks,1,2,* Damian Świeczkowski,3,* Marcin Balcerzak,4 Ewelina Drelich,4 Katarzyna Białoszewska,5 Natalia Cwalina,3 Jerzy Krysinski,1 Miłosz Jaguszewski,3 Annie Pouliot,6 Regis Vaillancourt6 1Department of Pharmaceutical Technology, Collegium Medicum in Bydgoszcz, Nicolaus University in Torun, Bydgoszcz-Torun, Poland; 2Piktorex Sp. z.o.o., Warsaw, Poland; 3First Department of Cardiology, Medical University of Gdansk, Gdansk, Poland; 4Farenta Polska, Warsaw, Poland; 5Department of Medical Psychology, Medical University of Warsaw, Warsaw, Poland; 6Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada *These authors contributed equally to this work Introduction: The search for new ways to optimize the use of medications by patients has led the pharmaceutical community to promote the idea of introducing pictograms into routine practice. The main intention of pictograms is to ease patient adherence and to reduce potential risks or errors associated with the use of medications. Purpose: To evaluate a series of pharmaceutical pictograms for patient comprehension. Patients and methods: The study was conducted in community pharmacies within a European Union country that belongs to the professional research network. Structured interviews were used to evaluate the pictograms for patient comprehension. This consisted of an assessment of the following: the transparency and translucency of the pictograms, health literacy, and pictogram recall. Participants were also given the opportunity to provide feedback on how to improve the pictograms. The primary endpoint was pictogram comprehension. Secondary outcomes included recall of the pictograms and pictogram translucency. Results: The study included 68 patients with whom face-to-face interviews were performed. Low transparency results (≤25% and extensive patient feedback in initial interviews led to the withdrawal of certain pictograms (n=15 from the evaluation. Among the pictograms included in

Higher diversity in fungal species discriminates children with type 1 diabetes mellitus from healthy control

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Kowalewska B

2016-04-01

Full Text Available Beata Kowalewska,1 Katarzyna Zorena,2 Małgorzata Szmigiero-Kawko,3 Piotr Wąż,4 Małgorzata Myśliwiec3 1Department of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, 2Department of Immunology and Environmental Microbiology, 3Clinic of Paediatrics, Diabetology and Endocrinology, 4Department of Nuclear Medicine, Medical University of Gdańsk, Gdańsk, Poland Objective: To conduct qualitative and quantitative assessment of yeast-like fungi in the feces of children and adolescents with type 1 diabetes mellitus (T1DM with respect to their metabolic control and duration of the disease.Materials and methods: The studied materials included samples of fresh feces collected from 53 children and adolescents with T1DM. Control group included 30 age- and sex-matched healthy individuals. Medical history was taken and physical examination was conducted in the two study arms. Prevalence of the yeast-like fungi in the feces was determined as well as their amounts, species diversity, drug susceptibility, and enzymatic activity.Results: The yeast-like fungi were found in the samples of feces from 75.4% of T1DM patients and 70% controls. In the group of T1DM patients, no correlation was found between age (Rs=0.253, P=0.068, duration of diabetes (Rs=−0.038, P=0.787, or body mass index (Rs=0.150, P=0.432 and the amount of the yeast-like fungi isolated in the feces. Moreover, no correlation was seen between the amount of the yeast-like fungi and glycated hemoglobin (Rs=0.0324, P=0.823, systolic blood pressure (Rs=0.102, P=0.483, or diastolic blood pressure (Rs=0.271, P=0.345.Conclusion: Our research has shown that children and adolescents with T1DM show higher species diversity of the yeast-like fungi, with Candida albicans being significantly less prevalent versus control subjects. Moreover, fungal species in patients with T1DM turn out to be more resistant to antifungal treatment. Keywords: children, diabetes mellitus type 1

Lumbar paravertebral blockade as intractable pain management method in palliative care

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Zaporowska-Stachowiak I

2013-09-01

Full Text Available Iwona Zaporowska-Stachowiak,1,2 Aleksandra Kotlinska-Lemieszek,3 Grzegorz Kowalski,3 Katarzyna Kosicka,4 Karolina Hoffmann,5 Franciszek Główka,4 Jacek Łuczak2 1Department of Pharmacology, 2Palliative Medicine In-patient Unit, University Hospital of Lord’s Transfiguration, 3Department of Palliative Care, 4Department of Physical Pharmacy and Pharmacokinetics, 5Department of Internal Medicine, Metabolic Disorders and Arterial Hypertension, Poznan University of Medical Sciences, Poznan, Poland Abstract: Optimal symptoms control in advanced cancer disease, with refractory to conventional pain treatment, needs an interventional procedure. This paper presents coadministration of local anesthetic (LA via paravertebral blockade (PVB as the alternative to an unsuccessful subcutaneous fentanyl pain control in a 71-year old cancer patient with pathological fracture of femoral neck, bone metastases, and contraindications to morphine. Bupivacaine in continuous infusion (0.25%, 5 mL · hour-1 or in boluses (10 mL of 0.125%–0.5% solution, used for lumbar PVB, resulted in pain relief, decreased demand for opioids, and led to better social interactions. The factors contributing to an increased risk of systemic toxicity from LA in the patient were: renal impairment; heart failure; hypoalbuminemia; hypocalcemia; and a complex therapy with possible drug–drug interactions. These factors were taken into consideration during treatment. Bupivacaine’s side effects were absent. Coadministered drugs could mask LA’s toxicity. Elevated plasma α1-acid glycoprotein levels were a protective factor. To evaluate the benefit-risk ratio of the PVB treatment in boluses and in constant infusion, bupivacaine serum levels were determined and the drug plasma half-lives were calculated. Bupivacaine’s elimination was slower when administered in constant infusion than in boluses (t½ = 7.80 hours versus 2.64 hours. Total drug serum concentrations remained within the safe

Interaktywna edukacja filozoficzna: Na Targowisku Ujawnień [Interactive philosophy teaching: At the fair of disclosure

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Katarzyna Kuczyńska

2014-03-01

Full Text Available The text consists of the theoretical introduction Interactive philosophy teaching, written by Katarzyna Kuczyńska, followed by a presentation (with a commentary of the philosophical workshop script At the Fair of Disclosures, created by Sebastian Wachowiak. The theoretical part refers to the idea of philosophy as a form of human acti- vity that stays in a strict correlation with everyday life. Using the idea as a referential point, the author distinguishes the following issues: (a the process of philosophical thinking, (b the results of this process – philosophical knowledge, (c the know- ledge of philosophy, as well as intellectual competence, crucial for developing one’s philosophical culture. She also provides an interactive model of teaching philosophy at school as the one she considers the most favorable. According to the given point of view, interactive philosophy teaching: (a points out the correlation of philosophical questions with existential experience of the individuals; (b creates environment for active philosophising for the students (the didactic situation aims at initiating the knowledge manufacturing process rather than simply reproducing the knowledge. Sebastian Wachowiak’s script At the Fair of Disclosures is an example of creat- ing educational situation within the interactive model of philosophy teaching. The goal of the lesson is to deepen the students’ understanding of identity as a category described through its public and social as well as intimate and private dimension (to show the multidimensionality of human life in public and social space; to re- cognise the moral threats resulting from the identity exposure. During the first part of the lesson, while the students are participating in the designed didactic game, the issue selected in accordance to the above criteria becomes the object of students’ experience. The second part of the lesson is a discussion which aims at stimulating the students

Archaeological and Paleontological Investigation at Kalaeloa (Barber’s Point), Honouliuli, ’EWA, O’Ahu Island, Federal Study Areas 1a and 1b, and State of Hawaii Optional Area 1,

Science.gov (United States)

1981-07-01

gravel, slightly sticky, slightly plastic, massive structure. Granule size limestone decreases with depth. Color whitens with depth influenced by neutral...fish. Vertebrae from shark or ray are present in 2787 and 2745 and fragments of large toothed jaws, tentatively identified as crevally (ulua) are present...a white enameled 5-gallon liquid dispenser sits on top a wooden crate. The barracks is wired for lighting with a drop-cord light over the desks

Ewa Głażewska, Urszula Kusio, Komunikacja niewerbalna. Płeć i kultura. Wybrane zagadnienia, Lublin, Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej, 2012, 255 s., ISBN 978-83-7784-177-8

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Paulina Banaśkiewicz

2014-07-01

Full Text Available Autorka recenzji opisuje pokrótce zawartość dwóch części książki na temat komunikacji niewerbalnej celem skupienia się na trzech walorach publikacji: konstrukcji książki, prezentacji niezbyt dobrze znanych w Polsce koncepcji wybitnych antropologów i socjologów oraz liczebności eksplikacji, które służą zilustrowaniu rozważań teoretycznych.English abstractThe author briefly describes the contents of the two parts of the book about non-verbal communication to focus on three qualities: design of the book, not very well known in Poland concepts of eminent anthropologists and sociologists and the number of explications, which illustrate the theoretical considerations. 

Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model

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Kurantowicz N

2017-04-01

Full Text Available Natalia Kurantowicz,1 Ewa Sawosz,1 Gabriela Halik,1 Barbara Strojny,1 Anna Hotowy,1 Marta Grodzik,1 Radosław Piast,2 Wanvimol Pasanphan,3 André Chwalibog4 1Department of Animal Nutrition and Biotechnology, Warsaw University of Life Sciences, 2Faculty of Chemistry, Warsaw University, Warsaw, Poland; 3Department of Materials Science, Faculty of Science, Kasetsart University, Bangkok, Thailand; 4Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: In the present study, the toxicity of six different types of carbon nanoparticles (CNPs was investigated using a chicken-embryo model. Fertilized chicken eggs were divided into the following treatment groups: placebo, diamond NPs, graphite NPs, pristine graphene, small graphene oxide, large graphene oxide, and reduced graphene oxide. Experimental solutions at a concentration of 500 µg/mL were administrated into the egg albumin. Gross pathology and the rate of survival were examined after 5, 10, 15, and 20 days of incubation. After 20 days of incubation, blood samples were collected and the weight of the body and organs measured. The relative ratio of embryo survival decreased after treatment all treatments except diamond NPs. There was no correlation between the rate of survival and the ζ-potential or the surface charge of the CNPs in solution. Body and organ weight, red blood-cell morphology, blood serum biochemical parameters, and oxidative damage in the liver did not differ among the groups. These results indicate that CNPs can remain in blood circulation without any major side effects, suggesting their potential applicability as vehicles for drug delivery or active compounds per se. However, there is a need for further investigation of their properties, which vary depending on production methods and surface functionalization. Keywords: nanoparticles, diamond, graphite, graphene, toxicity, red blood cells, oxidative stress, surface charge

Apresentação do Dossiê

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Maria Cecília Coelho

2013-12-01

Full Text Available Este dossiê reúne textos apresentados, em sua maioria, durante o XIX Congresso da Sociedade Brasileira de Estudos Clássicos e no decorrer do I Simpósio Luso-Brasileiro de Estudos Clássicos – O Futuro do Passado, que aconteceu em julho de 2013, em Brasília/Distrito Federal. O dossiê contém quatro artigos e um ensaio, lido em uma palestra, ao qual segue anexo um comentário de seu moderador. Três dos artigos são frutos do painel proposto e organizado, durante o XIX Congresso, pelo Núcleo de Estudos Antigos e Medievais da Faculdade de Letras da Universidade Federal de Minas Gerais (NEAM/FALE/UFMG, do qual sou membro. No painel, intitulado “Recepção da cultura greco-romana no cinema, no teatro e na literatura”, foram apresentados textos de autoria de professores da área de língua e literatura gregas, que trabalham na Argentina, nos Estados Unidos e na Polônia: Claudia Fernández (Universidade de La Plata, Eric Dugdale (Gustavus Adolphus College e Ewa Skwara (Adam-Mickiewicz University, respectivamente. Quanto ao ensaio, trata-se do texto do cineasta português João Canijo, em cuja obra se destaca a adaptação de tragédias gregas para o cinema. O ensaio é seguido do comentário de Christian Werner (Universidade de São Paulo, tradutor e professor de língua e literatura gregas. O quarto artigo, de minha autoria, apesar de ter sido resultado, em parte, de uma palestra que apresentei em outro momento (no VI Colóquio Filosofia e Ficção – Phantasia e Phantasmas, foi, pela proximidade com o tema do painel que coordenei nesse XIX Congresso, inserido neste dossiê.

Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy.

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Morales, Eva; Vilahur, Nadia; Salas, Lucas A; Motta, Valeria; Fernandez, Mariana F; Murcia, Mario; Llop, Sabrina; Tardon, Adonina; Fernandez-Tardon, Guillermo; Santa-Marina, Loreto; Gallastegui, Mara; Bollati, Valentina; Estivill, Xavier; Olea, Nicolas; Sunyer, Jordi; Bustamante, Mariona

2016-10-01

We conducted an epigenome-wide association study (EWAS) of DNA methylation in placenta in relation to maternal tobacco smoking during pregnancy and examined whether smoking-induced changes lead to low birthweight. DNA methylation in placenta was measured using the Illumina HumanMethylation450 BeadChip in 179 participants from the INfancia y Medio Ambiente (INMA) birth cohort. Methylation levels across 431 311 CpGs were tested for differential methylation between smokers and non-smokers in pregnancy. We took forward three top-ranking loci for further validation and replication by bisulfite pyrosequencing using data of 248 additional participants of the INMA cohort. We examined the association of methylation at smoking-associated loci with birthweight by applying a mediation analysis and a two-sample Mendelian randomization approach. Fifty CpGs were differentially methylated in placenta between smokers and non-smokers during pregnancy [false discovery rate (FDR) < 0.05]. We validated and replicated differential methylation at three top-ranking loci: cg27402634 located between LINC00086 and LEKR1, a gene previously related to birthweight in genome-wide association studies; cg20340720 (WBP1L); and cg25585967 and cg12294026 (TRIO). Dose-response relationships with maternal urine cotinine concentration during pregnancy were confirmed. Differential methylation at cg27402634 explained up to 36% of the lower birthweight in the offspring of smokers (Sobel P-value < 0.05). A two-sample Mendelian randomization analysis provided evidence that decreases in methylation levels at cg27402634 lead to decreases in birthweight. We identified novel loci differentially methylated in placenta in relation to maternal smoking during pregnancy. Adverse effects of maternal smoking on birthweight of the offspring may be mediated by alterations in the placental methylome. © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International

A participação dos ergonomistas nos projetos organizacionais

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Marçal Jackson

1999-12-01

Full Text Available Neste texto, pretende-se apresentar, em resposta às condicionantes conceituais e metodológicas colocadas por Salerno, uma abordagem metodológica, a abordagem da atividade futura (AAF, que viabiliza a participação dos ergonomistas em projetos organizacionais. Nessa abordagem, que tem a Análise Ergonômica do Trabalho (AET como base, os ergonomistas não sustentam unicamente a posição clínica, característica da AET, mas assumem o papel de "atores do processo de projeto" a fim de cooperar com os diferentes atores da empresa: diretores, gerentes, engenheiros, trabalhadores. Todavia, a participação efetiva da Ergonomia depende de nova forma de conceber a organização, que deve ser abordada não somente através de sua dimensão estrutural, mas também através das "regulações sociais necessárias à manutenção e à construção da organização do trabalho".In response to Salerno's theoretical and methodological constraints to ergonomists participation in organisational design process, this paper proposes a new approach based in future work activity forecasting. Even if the Ergonomie Work Analysis (EWA is the underlying methodological tool, in this approach, ergonomists must assume a new role, as "actors of the design process", and co-operate with the others company actors: managers, engineers, foremen and workers. But to be more effective, ergonomie intervention needs a new framework of "organisation" issues. To be more effective, it will be argued that one must approach organisâtionnal design not only by its structural components but also by its inherent social interactions and adjustments.

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.

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Shiwa, Yuh; Hachiya, Tsuyoshi; Furukawa, Ryohei; Ohmomo, Hideki; Ono, Kanako; Kudo, Hisaaki; Hata, Jun; Hozawa, Atsushi; Iwasaki, Motoki; Matsuda, Koichi; Minegishi, Naoko; Satoh, Mamoru; Tanno, Kozo; Yamaji, Taiki; Wakai, Kenji; Hitomi, Jiro; Kiyohara, Yutaka; Kubo, Michiaki; Tanaka, Hideo; Tsugane, Shoichiro; Yamamoto, Masayuki; Sobue, Kenji; Shimizu, Atsushi

2016-01-01

Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. In Experiment 1, whole blood from 16 volunteers was collected to examine the effect of a 24 h storage period at 4°C on DNA methylation profiles as measured using the Infinium HumanMethylation450 BeadChip array. Our statistical analysis showed that the P-value distribution of more than 450,000 CpG sites was similar to the theoretical distribution (in quantile-quantile plot, λ = 1.03) when comparing two control replicates, which was remarkably deviated from the theoretical distribution (λ = 1.50) when comparing control and storage conditions. We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λ adjusted = 1.14) by taking into account a cell-type composition variable. As such, we compared four respective sample collection protocols used in large-scale Japanese biobanks or cohorts as well as two control replicates. Systematic biases in DNA methylation profiles were observed between control and three of four protocols without adjustment of cell-type composition (λ = 1.12-1.45) and no remarkable biases were seen after adjusting for cell-type composition in all four protocols (λ adjusted = 1.00-1.17). These results revealed important implications for comparing DNA methylation profiles between blood specimens from different sources and may lead to discovery of disease-associated DNA methylation markers and the development of DNA methylation profile-based predictive risk models.

U.S. Tsunami Information technology (TIM) Modernization:Developing a Maintainable and Extensible Open Source Earthquake and Tsunami Warning System

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Hellman, S. B.; Lisowski, S.; Baker, B.; Hagerty, M.; Lomax, A.; Leifer, J. M.; Thies, D. A.; Schnackenberg, A.; Barrows, J.

2015-12-01

Tsunami Information technology Modernization (TIM) is a National Oceanic and Atmospheric Administration (NOAA) project to update and standardize the earthquake and tsunami monitoring systems currently employed at the U.S. Tsunami Warning Centers in Ewa Beach, Hawaii (PTWC) and Palmer, Alaska (NTWC). While this project was funded by NOAA to solve a specific problem, the requirements that the delivered system be both open source and easily maintainable have resulted in the creation of a variety of open source (OS) software packages. The open source software is now complete and this is a presentation of the OS Software that has been funded by NOAA for benefit of the entire seismic community. The design architecture comprises three distinct components: (1) The user interface, (2) The real-time data acquisition and processing system and (3) The scientific algorithm library. The system follows a modular design with loose coupling between components. We now identify the major project constituents. The user interface, CAVE, is written in Java and is compatible with the existing National Weather Service (NWS) open source graphical system AWIPS. The selected real-time seismic acquisition and processing system is open source SeisComp3 (sc3). The seismic library (libseismic) contains numerous custom written and wrapped open source seismic algorithms (e.g., ML/mb/Ms/Mwp, mantle magnitude (Mm), w-phase moment tensor, bodywave moment tensor, finite-fault inversion, array processing). The seismic library is organized in a way (function naming and usage) that will be familiar to users of Matlab. The seismic library extends sc3 so that it can be called by the real-time system, but it can also be driven and tested outside of sc3, for example, by ObsPy or Earthworm. To unify the three principal components we have developed a flexible and lightweight communication layer called SeismoEdex.

Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastomamultiforme cells

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Hinzmann M

2014-05-01

Full Text Available Mateusz Hinzmann,1 Slawomir Jaworski,1 Marta Kutwin,1 Joanna Jagiello,2 Rafal Kozinski,2 Mateusz Wierzbicki,1 Marta Grodzik,1 Ludwika Lipinska,2 Ewa Sawosz,1 Andrè Chwalibog31Division of Nanobiotechnology, Warsaw University of Life Sciences, 2Institute of Electronic Materials Technology, Warsaw, Poland; 3Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkAbstract: The carbon-based nanomaterial family consists of nanoparticles containing allotropes of carbon, which may have a number of interactions with biological systems. The objective of this study was to evaluate the toxicity of nanoparticles comprised of pristine graphene, reduced graphene oxide, graphene oxide, graphite, and ultradispersed detonation diamond in a U87 cell line. The scope of the work consisted of structural analysis of the nanoparticles using transmission electron microscopy, evaluation of cell morphology, and assessment of cell viability by Trypan blue assay and level of DNA fragmentation of U87 cells after 24 hours of incubation with 50 µg/mL carbon nanoparticles. DNA fragmentation was studied using single-cell gel electrophoresis. Incubation with nanoparticles containing the allotropes of carbon did not alter the morphology of the U87 cancer cells. However, incubation with pristine graphene and reduced graphene oxide led to a significant decrease in cell viability, whereas incubation with graphene oxide, graphite, and ultradispersed detonation diamond led to a smaller decrease in cell viability. The results of a comet assay demonstrated that pristine graphene, reduced graphene oxide, graphite, and ultradispersed detonation diamond caused DNA damage and were therefore genotoxic in U87 cells, whereas graphene oxide was not.Keywords: nanostructures, graphene, graphite, diamond, glioblastoma multiforme, geno toxicity

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.

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Yuh Shiwa

Full Text Available Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. In Experiment 1, whole blood from 16 volunteers was collected to examine the effect of a 24 h storage period at 4°C on DNA methylation profiles as measured using the Infinium HumanMethylation450 BeadChip array. Our statistical analysis showed that the P-value distribution of more than 450,000 CpG sites was similar to the theoretical distribution (in quantile-quantile plot, λ = 1.03 when comparing two control replicates, which was remarkably deviated from the theoretical distribution (λ = 1.50 when comparing control and storage conditions. We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λ adjusted = 1.14 by taking into account a cell-type composition variable. As such, we compared four respective sample collection protocols used in large-scale Japanese biobanks or cohorts as well as two control replicates. Systematic biases in DNA methylation profiles were observed between control and three of four protocols without adjustment of cell-type composition (λ = 1.12-1.45 and no remarkable biases were seen after adjusting for cell-type composition in all four protocols (λ adjusted = 1.00-1.17. These results revealed important implications for comparing DNA methylation profiles between blood specimens from different sources and may lead to discovery of disease-associated DNA methylation markers and the development of DNA methylation profile-based predictive risk models.

Application of a Tsunami Warning Message Metric to refine NOAA NWS Tsunami Warning Messages

Science.gov (United States)

Gregg, C. E.; Johnston, D.; Sorensen, J.; Whitmore, P.

2013-12-01

In 2010, the U.S. National Weather Service (NWS) funded a three year project to integrate social science into their Tsunami Program. One of three primary requirements of the grant was to make improvements to tsunami warning messages of the NWS' two Tsunami Warning Centers- the West Coast/Alaska Tsunami Warning Center (WCATWC) in Palmer, Alaska and the Pacific Tsunami Warning Center (PTWC) in Ewa Beach, Hawaii. We conducted focus group meetings with a purposive sample of local, state and Federal stakeholders and emergency managers in six states (AK, WA, OR, CA, HI and NC) and two US Territories (US Virgin Islands and American Samoa) to qualitatively asses information needs in tsunami warning messages using WCATWC tsunami messages for the March 2011 Tohoku earthquake and tsunami event. We also reviewed research literature on behavioral response to warnings to develop a tsunami warning message metric that could be used to guide revisions to tsunami warning messages of both warning centers. The message metric is divided into categories of Message Content, Style, Order and Formatting and Receiver Characteristics. A message is evaluated by cross-referencing the message with the operational definitions of metric factors. Findings are then used to guide revisions of the message until the characteristics of each factor are met. Using findings from this project and findings from a parallel NWS Warning Tiger Team study led by T. Nicolini, the WCATWC implemented the first of two phases of revisions to their warning messages in November 2012. A second phase of additional changes, which will fully implement the redesign of messages based on the metric, is in progress. The resulting messages will reflect current state-of-the-art knowledge on warning message effectiveness. Here we present the message metric; evidence-based rational for message factors; and examples of previous, existing and proposed messages.

Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells

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Niska K

2015-02-01

Full Text Available Karolina Niska,1 Katarzyna Pyszka,1 Cecylia Tukaj,2 Michal Wozniak,1 Marek Witold Radomski,3–5 Iwona Inkielewicz-Stepniak1 1Department of Medical Chemistry, 2Department of Electron Microscopy, Medical University of Gdansk, Gdansk, Poland; 3School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, The University of Dublin Trinity College, Dublin, Ireland; 4Kardio-Med Silesia, 5Silesian Medical University, Zabrze, Poland Abstract: Titanium dioxide (TiO2 nanoparticles (NPs are manufactured worldwide for a variety of engineering and bioengineering applications. TiO2NPs are frequently used as a material for orthopedic implants. However, to the best of our knowledge, the biocompatibility of TiO2NPs and their effects on osteoblast cells, which are responsible for the growth and remodeling of the human skeleton, have not been thoroughly investigated. In the research reported here, we studied the effects of exposing hFOB 1.19 human osteoblast cells to TiO2NPs (5–15 nm for 24 and 48 hours. Cell viability, alkaline phosphatase (ALP activity, cellular uptake of NPs, cell morphology, superoxide anion (O2•- generation, superoxide dismutase (SOD activity and protein level, sirtuin 3 (SIR3 protein level, correlation between manganese (Mn SOD and SIR, total antioxidant capacity, and malondialdehyde were measured following exposure of hFOB 1.19 cells to TiO2NPs. Exposure of hFOB 1.19 cells to TiO2NPs resulted in: (1 cellular uptake of NPs; (2 increased cytotoxicity and cell death in a time- and concentration-dependent manner; (3 ultrastructure changes; (4 decreased SOD and ALP activity; (5 decreased protein levels of SOD1, SOD2, and SIR3; (6 decreased total antioxidant capacity; (7 increased O2•- generation; and (8 enhanced lipid peroxidation (malondialdehyde level. The linear relationship between the protein level of MnSOD and SIR3 and between O2•- content and SIR3 protein level was observed. Importantly, the cytotoxic

Effects of intravitreal ranibizumab on the untreated eye and systemic gene expression profile in age-related macular degeneration

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Michalska-Małecka K

2016-03-01

Full Text Available Katarzyna Michalska-Małecka,1,2 Adam Kabiesz,2 Malgorzata W Kimsa,3 Barbara Strzałka-Mrozik,3 Maria Formińska-Kapuścik,2,4 Malgorzata Nita,5 Urszula Mazurek31Clinical Department of Ophthalmology, Medical University of Silesia, Katowice, Poland; 2University Center for Ophthalmology and Oncology, Independent Public Clinical Hospital, Medical University of Silesia, Katowice, Poland; 3Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland; 4Clinical Department of Children Ophthalmology, Medical University of Silesia, Katowice, Poland; 5Domestic and Specialized Medicine Centre “Dilmed”, Katowice, PolandAbstract: The purpose of this study was to evaluate the systemic effects of intravitreal ranibizumab (Lucentis treatment in patients with neovascular age-related macular degeneration (AMD. The impact of intravitreal ranibizumab injections on central retinal thickness (CRT of treated and contralateral untreated eyes, and differences in gene expression patterns in the peripheral blood mononuclear cells were analyzed. The study included 29 patients aged 50 years old and over with diagnosed neovascular AMD. The treatment was defined as 0.5 mg of ranibizumab injected intravitreally in the form of one injection every month during the period of 3 months. CRT was measured by optical coherence tomography. The gene expression profile was assigned using oligonucleotide microarrays of Affymetrix HG-U133A. Studies have shown that there was a change of CRT between treated and untreated eyes, and there were differences in CRT at baseline and after 1, 2, and 3 months of ranibizumab treatment. Three months after intravitreal injection, mean CRT was reduced in the treated eyes from 331.97±123.62 to 254.31±58.75 µm, while mean CRT in the untreated fellow eyes reduced from 251.07±40.29 to 235.45±36.21 µm at the same time. Furthermore, the research has shown

Physical and mental health aspects of elderly in social care in Poland

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Dobrzyn-Matusiak D

2014-10-01

Full Text Available Dorota Dobrzyn-Matusiak,1 Czeslaw Marcisz,2 Ewelina Bąk,3 Halina Kulik,1 Ewa Marcisz4 1Department of Nursing Propaedeutics, 2Department of Gerontology and Geriatric Nursing, School of Health Care, Medical University of Silesia, Katowice, Poland; 3Faculty of Health Sciences, University of Bielsko-Biała, Bielsko-Biała, Poland; 4Department of Anxiety Disorders, Hospital of Ministry of Internal Affairs, Katowice, Poland Background: The objective of the study was to evaluate health aspects in elderly individuals in social, institutional, and home care in Poland.Methods: A total of 300 elderly individuals in care in Poland were included in the study. The subjects were divided into three groups: residents of long-term care institutions (group I, residents of adult day-care homes (group II, and community-dwelling subjects (group III. Each group consisted of 100 subjects. Questionnaires evaluating the following physical and mental dimensions of health were used: SF-36 Health Survey, basic activities of daily living, instrumental activities of daily living, Geriatric Depression Scale, and Mini–mental state examination.Results: It was found that the health aspects of the elderly varied depending on whether care was provided in an institutionalized or a home environment, and the lowest health status was found in the elderly receiving in-home care. Furthermore, home-based elderly indicated significant limitations in performing basic activities of daily living and instrumental activities of daily living, as well as a higher prevalence of depression and cognitive impairment.Conclusion: The elderly in long-term institutionalized care, both in a residential home and adult day-care homes, were characterized by a better physical and mental health status than those receiving in-home care. It seemed that worse health status, including the more frequent depression occurrence and cognitive function disorders in the elderly using the nursing care at their homes

Polish Literature of the Holocaust. The First Instalment: 1939-1968

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Katarzyna Kuczyńska-Koschany

2015-01-01

Full Text Available The text is a critical attempt discussing the compendium Literatura polska wobec Zagłady, (“Polish Literature in the Face of the Holocaust” edited and published by three prominent scholarly experts on the subject: Sławomir Buryła, Dorota Krawczyńska and Jacek Leociak. This is the first of the three volumes of the series Reprezentacje Zagłady w kulturze polskiej (“Representations of the Holocaust in Polish Culture” – an endeavour which is imposing already in its first instalment concerning the years 1939-1968. The time frame of the abovementioned volume is marked by the date of the beginning of World War II (1939, resulting in the Holocaust of the Jews of Europe, and a “dry pogrom”, that is was the anti-Semitic campaign in Poland in 1968 (the campaign itself and its writings shall be examined in the following volume. A comprehensive and very carefully prepared monograph has been divided into two fundamental parts: concerning the literature reacting to the Holocaust conducted by Nazi Germany during the war (1939-1945 and discussing the literary echoes of that genocide in the years 1945-1968. The study and invaluable interpretational effort have been focused on personal document literature (Marta Janczewska, Jacek Leociak, the prose (Sławomir Buryła, Dorota Krawczyńska, the poetry (Piotr Matywiecki and the press (Ewa Koźmińska-Frejlak. A separate chapter has been devoted to a the “global text”, i.e., Archiwum Ringelbluma (“Ringelblum’s Archives”. Highly appreciating the entire volume as well as its individual fragments, recalling fundamental considerations and the ones concerning details, finally, proposing small corrections and pointing to minor shortcomings, the author of the critical review suggests the use of the formula “Polish literature of the Holocaust” (analogous to the formula coined by Grzegorz Niziołek “Polish theatre of the Holocaust” as the one principally necessary to be contrasted with the

[Moral and religious issues in health care].

Science.gov (United States)

Necek, Robert

2012-01-01

The paper summarises the moral and spiritual factors important in care for sick people. Medical care is one of the ancient forms of our activity as humans, expounding care for other people's well-being. The moral aspect of medical care is deeply rooted in constant daily interaction between the patient and the doctor aiming at easing symptoms, support, help, prevention and defense. Such teleological orientation of medicine is, according to John Paul II, made possible not so much by technology but by physician's conscience, wisdom and unlimited honesty. This is where ethics is needed to regulate that particular relation. This ethics stems from Christian morality, which raises our role as humans to that of guardians of dignity of another human being. Man is indeed the measure of all things, and this becomes the context for all relations including man's relation to God, but also relation of God to man. Thus, human dignity assumes the status of unconditional natural rule, inherently forestalling all legal arrangements. The morality of health care requires holistic approach, including care for body, mind, social interaction and spiritual needs. Only then, as explained by dr Ewa Kucharska, is it possible to answer patient's all needs. The moral side of the therapeutic contract bounds the doctor and the patient, alike. From this point of view, it is immoral not to cooperate with physicians in their strife for the preservation of health and life itself. Self negligence or active self harm (drugs, alcohol abuse, HIV/AIDS) are the utmost examples of such dishonesty. Finally, the imperative to bring hope and faith to the suffering, vests special importance in hospital chaplains, who bring good word, but most importantly the sacrament to those in need. The prayer in turn may evoke strong hope for cure, capable of supporting both soul and body. The suffering of man cannot be understood on rational grounds. It requires acceptance, and, above all, it requires faith. And this

In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma

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Jaworski S

2015-02-01

Full Text Available Sławomir Jaworski,1 Ewa Sawosz,1 Marta Kutwin,1 Mateusz Wierzbicki,1 Mateusz Hinzmann,1 Marta Grodzik,1 Anna Winnicka,2 Ludwika Lipinska,3 Karolina Włodyga,1 Andrè Chwalibog41Warsaw University of Life Science, Faculty of Animal Science, Division of Biotechnology and Biochemistry of Nutrition, 2Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, 3Institute of Electronic Materials Technology, Warsaw, Poland; 4University of Copenhagen, Department of Veterinary Clinical and Animal Sciences, Copenhagen, DenmarkAbstract: Graphene and its related counterparts are considered the future of advanced nanomaterials owing to their exemplary properties. However, information about their toxicity and biocompatibility is limited. The objective of this study is to evaluate the toxicity of graphene oxide (GO and reduced graphene oxide (rGO platelets, using U87 and U118 glioma cell lines for an in vitro model and U87 tumors cultured on chicken embryo chorioallantoic membrane for an in vivo model. The in vitro investigation consisted of structural analysis of GO and rGO platelets using transmission elec­tron microscopy, evaluation of cell morphology and ultrastructure, assessment of cell viability by XTT assay, and investigation of cell proliferation by BrdU assay. Toxicity in U87 glioma tumors was evaluated by calculation of weight and volume of tumors and analyses of ultrastructure, histology, and protein expression. The in vitro results indicate that GO and rGO enter glioma cells and have different cytotoxicity. Both types of platelets reduced cell viability and proliferation with increasing doses, but rGO was more toxic than GO. The mass and volume of tumors were reduced in vivo after injection of GO and rGO. Moreover, the level of apoptotic markers increased in rGO-treated tumors. We show that rGO induces cell death mostly through apoptosis, indicating the potential applicability of

Eerder anders as elders: Gerrie Snyman se bydrae in die konteks van die Gereformeerde teologie

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Hans J.M. van Deventer

2010-03-01

Full Text Available Rather different than elsewhere: Gerrie Snyman�s contribution in the context of Reformed theology Prof Gerrie Snyman�s book Om die Bybel anders te lees: �n etiek van Bybellees (2007 attracted considerable attention in Afrikaans-speaking reformed circles in South Africa. In this article, some of the responses to and reviews of the book are studied in order to assess the publication�s impact. Moreover, the article aims to determine whether the book will contribute to future reflections and discussions on the use of the Bible in this context. It is concluded that the preferred method of interpretation in the Reformed Church in South Africa calls for a thorough revision. The so-called �grammatical-historical method� of interpretation can no longer be regarded as the most appropriate and sole �Reformed method� of interpretation.�--- Abstract translated into Sipedi ---Go fapana le t�e dingwe: seabe sa Gerrie Snyman go teologie ya RefomoPuku ya Profesa Gerrie Snyman, Om die Bybel anders te lees: �n Etiek van Bybellees (2007, e gogile �edi ye kgolo ya maloko a kereke ya Refomo mo Afrika-Borwa(RCSA/GKSA. Mo pampiring ye re ithuta t�e dingwe t�a dikarabo le ditshekatsheko t�a puku ye go ela khuet�o ya yona. Go feta fao, pampiri ye e nepile go bona ge e ba puku ye e tlo ba le seabe go dikakanyo le dipoledi�ano mabapi le t�homi�o ya Beibele ditabeng t�a mohuta wo. Re ruma ka go re, mokgwa wa tshekatsheko ya Bibele wa Kereke ya Refomo mo Afrika-Borwa o hloka go lekodi�i�wa le go boelet�wa. Mokgwa wa go hlatholla Bibele ka go sekaseka popopolelo(gramatika le histori ya tlholego ya yona, o ka se sa t�ewa e le wona wa maleba o nno�i wa tshekatsheko goba go ba wona �Mokgwa wa Refomo� wa go fetleka Bibele.--- End of translation ---

Effects of immunosuppressive treatment on protein expression in rat kidney

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Kędzierska K

2014-09-01

Full Text Available Karolina Kędzierska,1 Katarzyna Sporniak-Tutak,2 Krzysztof Sindrewicz,2 Joanna Bober,3 Leszek Domański,1 Mirosław Parafiniuk,4 Elżbieta Urasińska,5 Andrzej Ciechanowicz,6 Maciej Domański,1 Tomasz Smektała,2 Marek Masiuk,5 Wiesław Skrzypczak,6 Małgorzata Ożgo,6 Joanna Kabat-Koperska,1 Kazimierz Ciechanowski1 1Department of Nephrology, Transplantology, and Internal Medicine, 2Department of Dental Surgery, 3Department of Medical Chemistry, 4Department of Forensic Medicine, 5Department of Pathomorphology, Pomeranian Medical University, 6Department of Physiology, Cytobiology, and Proteomics, West Pomeranian University of Technology, Szczecin, Poland Abstract: The structural proteins of renal tubular epithelial cells may become a target for the toxic metabolites of immunosuppressants. These metabolites can modify the properties of the proteins, thereby affecting cell function, which is a possible explanation for the mechanism of immunosuppressive agents' toxicity. In our study, we evaluated the effect of two immunosuppressive strategies on protein expression in the kidneys of Wistar rats. Fragments of the rat kidneys were homogenized after cooling in liquid nitrogen and then dissolved in lysis buffer. The protein concentration in the samples was determined using a protein assay kit, and the proteins were separated by two-dimensional electrophoresis. The obtained gels were then stained with Coomassie Brilliant Blue, and their images were analyzed to evaluate differences in protein expression. Identification of selected proteins was then performed using mass spectrometry. We found that the immunosuppressive drugs used in popular regimens induce a series of changes in protein expression in target organs. The expression of proteins involved in drug, glucose, amino acid, and lipid metabolism was pronounced. However, to a lesser extent, we also observed changes in nuclear, structural, and transport proteins' synthesis. Very slight differences

European perspective on the management of rheumatoid arthritis: clinical utility of tofacitinib

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Kawalec P

2017-12-01

Full Text Available Paweł Kawalec,1 Katarzyna Śladowska,2 Iwona Malinowska-Lipień,3 Tomasz Brzostek,3 Maria Kózka4 1Drug Management Department, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, 2Department of Experimental Hematology, Institute of Zoology and Biomedical Research, Faculty of Biology and Earth Sciences, Jagiellonian University, Krakow, Poland; 3Department of Internal and Community Nursing, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland; 4Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland Abstract: Xeljanz® (tofacitinib is an oral small-molecule inhibitor that reversibly inhibits Janus-activated kinase (JAK-dependent cytokine signaling, thus reducing inflammation. As a result of these mechanisms, effects on the immune system such as a moderate decrease in the total lymphocyte count, a dose-dependent decrease in natural killer (NK cell count, and an increase in B-cell count have been observed. Therefore, tofacitinib provides an innovative approach to modulating the immune and inflammatory responses in patients with rheumatoid arthritis (RA, which is especially important in individuals who do not respond to tumor necrosis factor inhibitors or show a loss of response over time. The aim of this article was to review studies on the pharmacology, mode of action, pharmacokinetics, efficacy, and safety of tofacitinib in patients with RA. Tofacitinib has been shown to reduce symptoms of RA and improve the quality of life in the analyzed groups of patients. Moreover, it showed high efficacy and an acceptable safety profile in Phase III randomized clinical trials on RA and was the first JAK inhibitor approved by the US Food and Drug Administration (FDA and European Medicines Agency (EMA in the RA therapy, thus providing a useful alternative

Evaluation of the effectiveness and safety of glucocorticoids intravitreal implant therapy in macular edema due to retinal vein occlusion

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Michalska-Małecka K

2016-05-01

Full Text Available Katarzyna Michalska-Małecka,1,2 Aneta Gaborek,2 Mariusz Nowak,3 Tomasz Halat,4 Mariola Pawłowska,2 Dorota Śpiewak2 1Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, 2University Center of Ophthalmology and Oncology, Independent Public Clinical Hospital, Medical University of Silesia, Katowice, 3Pathophysiology Division, Department of Pathophysiology and Endocrinology, Medical University of Silesia, School of Medicine with Division of Density, Zabrze, 4Education and Medical Simulation Center, Medical University of Silesia, Katowice, Poland Abstract: The purpose of this study was to evaluate the impact of intravitreal dexamethasone implant (Ozurdex on macular morphology and functions in eyes with macular edema (ME secondary to retinal vein occlusion. Efficacy outcomes of the treatment were best-corrected visual acuity (BCVA and central retinal thickness (CRT. Safety outcomes were intraocular pressure and cornea endothelial cell density. The study was conducted by the prospective analysis on 36 patients (17 women and 19 men aged 28–77 years (the average age was 58±15 years treated with the injection of dexamethasone implant because of the persistent ME at the Department of Ophthalmology and Ophthalmology Outpatient Clinic of the University Centre of Ophthalmology and Oncology in Katowice. The studied group included 16 patients with central retinal vein occlusion (16 eyes, and 20 patients with branch retinal vein occlusion (20 eyes. We found a significant increase of BCVA after first, second, and third month of treatment. Six months after the treatment, BCVA decreased, although not significantly compared with the value obtained in the third month. Two months after the intravitreal implantation of dexamethasone delivery system, CRT was 338±163 µm and was significantly lower compared with pretreatment value. Between third and sixth month after the treatment, we found insignificant increase of

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

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Sadek B

2016-11-01

Full Text Available Bassem Sadek,1 Ali Saad,1 Gniewomir Latacz,2 Kamil Kuder,2 Agnieszka Olejarz,2 Tadeusz Karcz,2 Holger Stark,3 Katarzyna Kieć-Kononowicz2 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 2Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland; 3Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University, Düsseldorf, Germany Abstract: A series of twelve novel non-imidazole-based ligands (3–14 was developed and evaluated for its in vitro binding properties at the human histamine H3 receptor (hH3R. The novel ligands were investigated for their in vivo protective effects in different seizure models in male adult rats. Among the H3R ligands (3–14 tested, ligand 14 showed significant and dose-dependent reduction in the duration of tonic hind limb extension in maximal electroshock (MES-induced seizure model subsequent to acute systemic administration (5, 10, and 20 mg/kg, intraperitoneally, whereas ligands 4, 6, and 7 without appreciable protection in MES model were most promising in pentylenetetrazole (PTZ model. Moreover, the protective effect observed for ligand 14 in MES model was lower than that observed for the reference drug phenytoin and was entirely abrogated when rats were co-administered with the brain-penetrant H1R antagonist pyrilamine (PYR but not the brain-penetrant H2R antagonist zolantidine (ZOL, demonstrating that histaminergic neurotransmission by activation of postsynaptically located H1Rs seems to be involved in the protective action. On the contrary, PYR and ZOL failed to abrogate the full protection provided by 4 in PTZ model and the moderate protective effect by 14 in strychnine (STR model. Moreover, the experimental and in silico estimation of properties such as metabolism was

Assessment of selected quality fields of nursing care in neurosurgical wards: a prospective study of 530 people – multicenter studies

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Ślusarz R

2014-08-01

Full Text Available Robert Ślusarz,1 Monika Biercewicz,2 Ewa Barczykowska,3 Beata Haor,4 Mariola Głowacka5 1Neurological and Neurosurgical Nursing Department, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, 2Clinic of Geriatrics, 3Nursing Department, Collegium Medicum, Nicolaus Copernicus University, Torun, 4Faculty of Health Science, University of Humanities and Economics in Wloclawek, Wloclawek, 5Institute of Health Sciences, State School of Higher Professional Education in Plock, Plock, Poland Background: One of the elements influencing the assessment of nursing care quality is the assessment of the nurse’s functions that determine the nurse’s particular tasks. The aim of this work was to assess selected tasks involved in the nurse’s caring function, which influence nursing care quality on neurosurgical wards, on the basis of patients’ and nursing staff’s opinions.Materials and methods: The research was carried out on neurosurgical wards in Poland on a group of 455 patients and 75 nurses. In order to assess nursing care quality, an author’s original questionnaire (Questionnaire – Patient Satisfaction was used.Results: Statistically significant differences concerned particular groups (both patients and nurses in the assessment of selected issues: providing information about performed activities and operations (P=0.000 and P=0.040, respecting personal dignity and assuring discretion during the operations (P=0.000 and P=0.001, speed of response to patient’s requests (P=0.000 and P=0.000, time availability of nurses for the patient (P=0.000 and P=0.000, providing information about further self-care at home (P=0.032, P=0.008, and nurses’ attitude (kindness, courtesy, tenderness, care to patients (patient’s assessment only P=0.000.Conclusion: Selected tasks in the field of the caring function of nurses were assessed differently by particular groups. There were no statistically significant differences in the assessment of particular

Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis

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Zielinska M

2011-12-01

Full Text Available Marlena Zielinska1,2, Ewa Sawosz1, Marta Grodzik1, Mateusz Wierzbicki1, Maria Gromadka1, Anna Hotowy3, Filip Sawosz3, Andrzej Lozicki1, Andrè Chwalibog31Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life sciences, Warsaw, 2The Kielanowski Institute of Animal Physiology and Nutrition, Jablonna, Poland; 3Department of Basic Animal and Veterinary sciences, University of copenhagen, Frederiksberg, DenmarkPurpose: It was hypothesized that heparan sulfate (HS as an essential compound for myogenesis and nanoparticles of gold (nano-Au as highly reactive compounds can affect muscle development as a consequence of molecular regulation of muscle cell formation, and that these effects may be enhanced by a complex of HS conjugated with nano-Au. The objective of the present study was to determine the effect of administration of nano-Au, HS, and a nano-Au+HS complex on the morphological and molecular characteristics of breast muscle during embryogenesis.Methods: Chicken embryos were used as in vivo model. Fertilized chicken eggs (n = 350 were randomly divided into the control group and the groups treated with nano-Au, HS, and nano-Au+HS. The experimental solutions were given in ovo on the first day of incubation and the embryos were evaluated on day 20 of incubation. The methods included biochemical indi- ces in blood, immunohistochemistry, microscopy (transmission electron microscopy, scanning electron microscopy, confocal, and gene expression at the messenger ribonucleic acid and protein levels.Results: The treatments did not adversely affect mortality, organ weight, and homeostasis of the embryos. HS stimulated the development and maturation of breast muscle by increasing the number of nuclei, satellite cells, and muscle fibers and affected the expression of basic fibroblast growth factor-2 and paired-box transcription factor-7. Furthermore, the nano-Au+HS complex contributed to the increased number of myocytes and nuclei in

Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.

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Emeny, Rebecca T; Baumert, Jens; Zannas, Anthony S; Kunze, Sonja; Wahl, Simone; Iurato, Stella; Arloth, Janine; Erhardt, Angelika; Balsevich, Georgia; Schmidt, Mathias V; Weber, Peter; Kretschmer, Anja; Pfeiffer, Liliane; Kruse, Johannes; Strauch, Konstantin; Roden, Michael; Herder, Christian; Koenig, Wolfgang; Gieger, Christian; Waldenberger, Melanie; Peters, Annette; Binder, Elisabeth B; Ladwig, Karl-Heinz

2018-01-01

Epigenetic regulation in anxiety is suggested, but evidence from large studies is needed. We conducted an epigenome-wide association study (EWAS) on anxiety in a population-based cohort and validated our finding in a clinical cohort as well as a murine model. In the KORA cohort, participants (n=1522, age 32-72 years) were administered the Generalized Anxiety Disorder (GAD-7) instrument, whole blood DNA methylation was measured (Illumina 450K BeadChip), and circulating levels of hs-CRP and IL-18 were assessed in the association between anxiety and methylation. DNA methylation was measured using the same instrument in a study of patients with anxiety disorders recruited at the Max Planck Institute of Psychiatry (MPIP, 131 non-medicated cases and 169 controls). To expand our mechanistic understanding, these findings were reverse translated in a mouse model of acute social defeat stress. In the KORA study, participants were classified according to mild, moderate, or severe levels of anxiety (29.4%/6.0%/1.5%, respectively). Severe anxiety was associated with 48.5% increased methylation at a single CpG site (cg12701571) located in the promoter of the gene encoding Asb1 (β-coefficient=0.56 standard error (SE)=0.10, p (Bonferroni)=0.005), a protein hypothetically involved in regulation of cytokine signaling. An interaction between IL-18 and severe anxiety with methylation of this CpG cite showed a tendency towards significance in the total population (p=0.083) and a significant interaction among women (p=0.014). Methylation of the same CpG was positively associated with Panic and Agoraphobia scale (PAS) scores (β=0.005, SE=0.002, p=0.021, n=131) among cases in the MPIP study. In a murine model of acute social defeat stress, Asb1 gene expression was significantly upregulated in a tissue-specific manner (p=0.006), which correlated with upregulation of the neuroimmunomodulating cytokine interleukin 1 beta. Our findings suggest epigenetic regulation of the stress

As estratégias operatórias e a gestão da informação no trabalho de enfermagem, no contexto hospitalar Las estrategias operatórias y la gestión de la información del trabajo de enfermeros en el entorno hospitalario The operatory strategies and information process of the nursing work in hospital context

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Diana Lúcia Moura Pinho

2003-03-01

Full Text Available O estudo analisa as estratégias operatórias de gestão da informação, utilizadas pelos enfermeiros no contexto hospitalar para regular o trabalho. O quadro teórico inscreve-se no campo da ergonomia, articulando conceitos de regulação da atividade, representações para e na ação. A Análise Ergonômica do Trabalho - AET orientou a coleta de dados. Os resultados demonstram que as estratégias adotadas pelos enfermeiros apóiam-se na utilização de um recurso informal externo (anotações pessoais que visa, sobretudo, reduzir a carga mental de trabalho e garantir a fiabilidade de suas ações.El presente estudio investiga las estrategias operatorias en la gestión de la información utilizadas por los enfermeros, en el entorno hospitalario, para regular su trabajo. El cuadro teórico de referencia adoptado se incluye en el campo de la ergonomía articulando conceptos de conducta de regulación y representaciones para y en la acción. El " Análisis Ergonómico del Trabajo - AET " orientó la recolección de los datos. Los resultados demuestran que las estrategias cognitivas adoptadas por los enfermeros en la gestión de la información se apoya en la elaboración de anotaciones personales, con el objetivo, sobretodo, de reducir la carga de trabajo mental y garantizar la fiabilidad de sus acciones.The paper examines the relationship between operatory strategies and information process used by nurses, in hospital context, in order to regulate their ongoing activities. As a conceptual framework, a cognitive ergonomics model was adopted, linking concepts of work regulation and representation to action. The Ergonomics Work Analyses tool (EWA was used to collect data. The results show that the cognitive strategies used by nurses, in the decision-making process, are based on their ongoing activities as in the preparation of personal notes, aiming, in particular, at reducing their mental workload and assuring the viability of their actions.

Social cognitive and neurocognitive deficits in inpatients with unilateral thalamic lesions — pilot study

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Wilkos E

2015-04-01

Full Text Available Ewelina Wilkos,2 Timothy JB Brown,3 Ksenia Slawinska,1 Katarzyna A Kucharska2,3 1Department of Neurology, 2Department of Neuroses, Personality and Eating Disorders Institute of Psychiatry and Neurology, Warsaw, Poland; 3Department of Medical Education, Hull York Medical School, Hull, UK Background: The essential role of the thalamus in neurocognitive processes has been well documented. In contrast, relatively little is known about its involvement in social cognitive processes such as recognition of emotion, mentalizing, or empathy. The aim of the study: This study was designed to compare the performance of eight patients (five males, three females, mean age ± SD: 63.7±7.9 years at early stage of unilateral thalamic lesions and eleven healthy controls (six males, five females, 49.6±12.2 years in neurocognitive tests (CogState Battery: Groton Maze Learning Test, GML; Groton Maze Learning Test-Delayed Recall, GML-DR; Detection Task, DT; Identification Task, IT; One Card Learning Task, OCLT; One Back Task, OBT; Two Back Task, TBT; Set-Shifting Task, S-ST and other well-known tests (Benton Visual Retention Test, BVRT; California Verbal Learning Test, CVLT; The Rey-Osterrieth Complex Figure Test, ROCF; Trail Making Test, TMT part A and B; Color – Word Stroop Task, CWST; Verbal Fluency Test, VFT, and social cognitive tasks (The Penn Emotion Recognition Test, ER40; Penn Emotion Discrimination Task, EmoDiff40; The Penn Emotional Acuity Test, PEAT40; Reading the Mind in the Eyes Test, revised version II; Toronto Alexithymia Scale, TAS-20. Methods: Thalamic-damaged subjects were included if they experienced a single-episode ischemic stroke localized in right or left thalamus. The patients were examined at 3 weeks after the stroke onset. All were right handed. In addition, the following clinical scales were used: the Mini-Mental State Examination (MMSE, Spielberger State-Trait Anxiety Inventory (STAI, Beck Depression Inventory (BDI II. An inclusion

Encapsulation technology of MR6 spent fuel and quality analysis of the EK-10 and WWR-SM spent fuel stored more than 30 years in wet conditions

Energy Technology Data Exchange (ETDEWEB)

Borek-Kruszewska, E.; Bykowski, W.; Chwaszczewski, S.; Czajkowski, W.; Madry, M. [Institute of Atomic Energy, Otwock -Swierk (Poland)

2002-07-01

The research reactor MARIA has been in operation for more than twenty years and all the spent fuel assemblies used since the first commissioning of the reactor are stored in wet facility on site. The present paper deals with the spent fuel MR-6 encapsulation technology in MARIA reactor. The encapsulated spent MR-6 fuel will be stored under water in the same pool unless some other solution is available. The capsules made of stainless steel are capable to accommodate one MR-6 fuel assembly. The encapsulation process is performed in the hot cell by the MARIA reactor. The spent fuel having its leg cut off is loaded to the transport cylinder manually and next transferred to a trolley. The trolley is moving to a position directly below the entrance to the hot cell and the spent fuel is entering the hot cell. The spent fuel assembly is then put into the drying cell. Dried out spent fuel is moved into the capsule mounted on the grip of the machine. Next, the capsule lid is pressed in and welded. After the leak test and filling up with helium the capsule returns from the hot cell to the pool. The hermetic capsule is sunk back into the water and positioned in the separator . The results presented earlier show, that the limiting time of WWR-SM and Ek-10 type spent fuel residence in wet storage is about 40-45 years. Therefore, the systematic quality investigation of all Ek-10 fuel elements and WWR-SM fuel assemblies discharged from EWA reactor in the period of 1959-1969 was performed. Altogether, about 2500 Ek-10 fuel elements and 47 WWR-SM fuel assemblies were investigated. The results of these investigations are presented in the present work. The sipping test, visual investigation and ultrasonic techniques were used for that purpose. The radioactive isotope Cs-137 was used as the indicator of fission product release from the fuel assembly. Taking into account the value of Cs-137 release from damaged WWR-SM fuel assembly the criteria of damaged fuel assembly were proposed. It

Editorial

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Mirosław Pawlak

2011-08-01

Full Text Available The current issue of Studies in Second Language Learning and Teaching brings together six contributions written by scholars from Poland and abroad which deal with a wide array of issues related to learning and teaching additional languages in different educational contexts. First, Weronika Szubko-Sitarek reports the findings of two experimental studies conducted within the lexical decision task paradigm which aimed to investigate the cognate facilitation effect in the process of recognizing words in a third language by Polish unbalanced trilinguals who, in addition to their mother tongue, were proficient in English and had variable command of German. In the next paper, Sane M. Yagi and Saleh Al-Salman make a strong case for the use of tracking software in writing pedagogy as a tool for providing invaluable insights into the process of composing texts, but also a method of stimulating reflection and promoting strategic learning. The research-based contributions by Ewa Waniek-Klimczak and Aleksandra Wach, in turn, shift the emphasis to sociolinguistic issues. The former presents the findings of a qualitative study which examined the acculturation patterns of three recent Polish immigrants to the United Kingdom, who were expert users of English, in relation to their formal and informal language learning experiences, while the latter uses questionnaire data obtained from a respectable sample of Polish-speaking English majors to shed light on their preferences concerning pronunciation norms based on the native-speaker model and the Lingua Franca Core. The last two papers included in this issue report the findings of studies exploring the role of anxiety in learning foreign language skills and subsystems. In the first of these, Christina Gkonou examines the interfaces between speaking and writing anxiety manifested by Greek learners of English as a foreign language in a private school setting and, in the second, Magdalena Szyszka taps the relationship

Prenatal Exposure to Maternal Cigarette Smoking and DNA Methylation: Epigenome-Wide Association in a Discovery Sample of Adolescents and Replication in an Independent Cohort at Birth through 17 Years of Age

Science.gov (United States)

Lee, Ken W.K.; Richmond, Rebecca; Hu, Pingzhao; French, Leon; Shin, Jean; Bourdon, Celine; Reischl, Eva; Waldenberger, Melanie; Zeilinger, Sonja; Gaunt, Tom; McArdle, Wendy; Ring, Susan; Woodward, Geoff; Bouchard, Luigi; Gaudet, Daniel; Smith, George Davey; Relton, Caroline; Paus, Tomas

2014-01-01

Background: Prenatal exposure to maternal cigarette smoking (prenatal smoke exposure) had been associated with altered DNA methylation (DNAm) at birth. Objective: We examined whether such alterations are present from birth through adolescence. Methods: We used the Infinium HumanMethylation450K BeadChip to search across 473,395 CpGs for differential DNAm associated with prenatal smoke exposure during adolescence in a discovery cohort (n = 132) and at birth, during childhood, and during adolescence in a replication cohort (n = 447). Results: In the discovery cohort, we found five CpGs in MYO1G (top-ranking CpG: cg12803068, p = 3.3 × 10–11) and CNTNAP2 (cg25949550, p = 4.0 × 10–9) to be differentially methylated between exposed and nonexposed individuals during adolescence. The CpGs in MYO1G and CNTNAP2 were associated, respectively, with higher and lower DNAm in exposed versus nonexposed adolescents. The same CpGs were differentially methylated at birth, during childhood, and during adolescence in the replication cohort. In both cohorts and at all developmental time points, the differential DNAm was in the same direction and of a similar magnitude, and was not altered appreciably by adjustment for current smoking by the participants or their parents. In addition, four of the five EWAS (epigenome-wide association study)–significant CpGs in the adolescent discovery cohort were also among the top sites of differential methylation in a previous birth cohort, and differential methylation of CpGs in CYP1A1, AHRR, and GFI1 observed in that study was also evident in our discovery cohort. Conclusions: Our findings suggest that modifications of DNAm associated with prenatal maternal smoking may persist in exposed offspring for many years—at least until adolescence. Citation: Lee KW, Richmond R, Hu P, French L, Shin J, Bourdon C, Reischl E, Waldenberger M, Zeilinger S, Gaunt T, McArdle W, Ring S, Woodward G, Bouchard L, Gaudet D, Davey Smith G, Relton C, Paus T

Bezpieczne formy aktywności fizycznej dla kobiet w ciąży = Secure forms of physical activity for pregnant women

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Katarzyna Urtnowska

2016-05-01

4Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego w Bydgoszczy           mgr Katarzyna Urtnowska1, dr n. med. Irena Bułatowicz2, dr hab. n. med. Grzegorz Ludwikowski3, dr hab. Walery Zukow4 1Uczestnik studiów dokotranckich z zakresu Nauk o Zdrowiu; Zakład Medycyny Rozdrodu i Andrologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu 2Katedra Fizjoterapii - Zakład Fizjoterapii Klinicznej, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu 3Zakład Medycyny Rozdrodu i Andrologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy Uniwersytet Mikołaja Kopernika w Toruniu 4Wydział Kultury Fizycznej, Zdrowia i Turystyki, Uniwersytet Kazimierza Wielkiego w Bydgoszczy           Słowa kluczowe: ciąża, aktywność fizyczna, sport. Keywords: pregnancy, physical activity, sport.           Streszczenie Kobieta spodziewać się dziecka w dzisiejszych czasach ma wiele możliwości podjęcia bezpiecznej formy aktywności fizycznej. Z odrobiną racjonalnego podejścia może kontynuować uprawianie ulubionego sportu, lub uczestniczyć w zajęciach przygotowanych specjalnie dla ciężarnych. Aktywność fizyczna uprawiana regularnie w trakcie ciąży jest kluczowym czynnikiem wpływającym na zdrowie i samopoczucie matki. Ćwiczenia wpływają korzystnie na stan zdrowia poprzez zmniejszenie dolegliwości bólowych kręgosłupa, ogólną poprawę lub brak pogorszenia sprawności fizycznej, zapobieganie nadmiernemu przyrostowi masy ciała i poprawę samopoczucia ciężarnej. Dodatkowym, a zarazem najważniejszym efektem jest zwiększenie wydolności fizycznej niezbędnej do porodu siłami natury i skrócenie czasu jego przebiegu oraz czasu regeneracji organizmu w połogu, a co za tym idzie, szybszy powrót do formy sprzed ciąży.     Abstract A women expect a child a child today has a lot of possibilities for secure forms of physical activity. With

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

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Bastaki SM

2018-01-01

Full Text Available Salim M Bastaki,1 Yousef M Abdulrazzaq,2 Mohamed Shafiullah,1 Małgorzata Więcek,3 Katarzyna Kieć-Kononowicz,3 Bassem Sadek1 1Department of Pharmacology and Therapeutics, College of Medicine and Health Science, United Arab Emirates University, Al Ain, 2Department of Medical Education, Dubai Health Authority, Dubai, UAE; 3Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna, Kraków, Poland Abstract: The imidazole-based H3R antagonist 2-18 with high in vitro H3R antagonist affinity, excellent in vitro selectivity profile, and high in vivo H3R antagonist potency was tested for its anticonvulsant effect in maximal electroshock (MES-induced convulsions in mice having valproic acid (VPA as a reference antiepileptic drug (AED. Additionally, H3R antagonist 2-18 was evaluated for its reproductive toxicity in the same animal species. The results show that acute systemic administration (intraperitoneal; i.p. of H3R antagonist 2-18 (7.5, 15, 30, and 60 mg/kg, i.p. significantly and dose dependently protected male as well as female mice against MES-induced convulsion. The protective action observed for H3R antagonist 2-18 in both mice sexes was comparable to that of VPA and was reversed when mice were pretreated with the selective H3R agonist (R-alpha-methylhistamine (RAMH, 10 mg/kg, i.p.. Moreover, the results show that acute systemic administration of single (7.5, 15, 30, or 60 mg/kg, i.p. or multiple doses (15×3 mg/kg, i.p. of H3R antagonist 2-18 on gestation day (GD 8 or 13 did not affect the maternal body weight of mice when compared with the control group. Furthermore, no significant differences were observed in the average number of implantations and resorptions between the control and H3R antagonist 2-18-treated group at the early stages of gestation and the organogenesis period. However, oral treatment with H3R antagonist 2-18 (15 mg/kg on GD 8 induced a reduced number of

Bupivacaine administered intrathecally versus rectally in the management of intractable rectal cancer pain in palliative care

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Zaporowska-Stachowiak I

2014-10-01

Full Text Available Iwona Zaporowska-Stachowiak,1,2 Grzegorz Kowalski,3 Jacek Łuczak,2 Katarzyna Kosicka,4 Aleksandra Kotlinska-Lemieszek,3 Maciej Sopata,3 Franciszek Główka4 1Chair and Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland; 2Palliative Medicine In-patient Unit, University Hospital of Lord's Transfiguration, Poznan University of Medical Sciences, Poznan, Poland; 3Palliative Medicine Chair and Department, Poznan University of Medical Sciences, Poznan, Poland; 4Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, Poznan, Poland Background: Unacceptable adverse effects, contraindications to and/or ineffectiveness of World Health Organization step III "pain ladder" drugs causes needless suffering among a population of cancer patients. Successful management of severe cancer pain may require invasive treatment. However, a patient's refusal of an invasive procedure necessitates that clinicians consider alternative options. Objective: Intrathecal bupivacaine delivery as a viable treatment of intractable pain is well documented. There are no data on rectal bupivacaine use in cancer patients or in the treatment of cancer tenesmoid pain. This study aims to demonstrate that bupivacaine administered rectally could be a step in between the current treatment options for intractable cancer pain (conventional/conservative analgesia or invasive procedures, and to evaluate the effect of the mode of administration (intrathecal versus rectal on the bupivacaine plasma concentration.Cases: We present two Caucasian, elderly inpatients admitted to hospice due to intractable rectal/tenesmoid pain. The first case is a female with vulvar cancer, and malignant infiltration of the rectum/vagina. Bupivacaine was used intrathecally (0.25–0.5%, 1–2 mL every 6 hours. The second case is a female with ovarian cancer and malignant rectal infiltration. Bupivacaine was adminstered rectally (0.05–0.1%, 100 m

Wiedza kobiet leczących się z powodu osteoporozy na temat ogólnej wiedzy o chorobie i czynników jej ryzyka = Knowledge of women treated for osteoporosis on the general knowledge about the disease and its risk factors

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Katarzyna Pawlikowska-Łagód

2016-05-01

3Department of Pathology and Speech Rehabilitation, Medical University of Lublin           mgr Pawlikowska-Łagód Katarzyna1, dr n. o zdr. Janiszewska Mariola2, mgr Firlej Ewelina2, Dąbska Olga3, dr hab. n med. Sak Jarosław1 1Zakład Etyki i Filozofii Człowieka, Uniwersytet Medyczny w Lublinie 2Katedra Zdrowia Publicznego, Uniwersytet Medyczny w Lublinie 3Zakład Patologii i Rehabilitacji Mowy, Uniwersytet Medyczny w Lublinie   mgr Pawlikowska-Łagód Katarzyna1, dr n. o zdr. Janiszewska Mariola2, mgr Firlej Ewelina2, Dąbska Olga3, dr hab. n med. Sak Jarosław1 1Department of Ethics and Human Philosophy, Medical University of Lublin, Poland 2Faculty of Health Science, Medical University of Lublin, Poland 3Department of Pathology and Speech Rehabilitation, Medical University of Lublin           Słowa kluczowe: wiedza, osteoporoza, kobiety, czynniki ryzyka Keywords: knowledge, osteoporosis, women, risk factors   Streszczenie Osteoporoza stanowi jeden z istotnych problemów zdrowotnych, społecznych i ekonomicznych współczesnego świata. Jest chorobą obarczoną ryzykiem trwałego kalectwa i z powodu powikłań wcześniejszej śmiertelności.  Ryzyko zachorowania, dotyczące kobiet wzrasta głównie po 65 roku życia. Szacuje się, że na całym świecie osteoporoza dotyka 200 mln kobiet, z których około 20 – 25% dozna urazu w postaci złamania kości. Biorąc pod uwagę fakt wydłużenia życia statystycznej Polki, należy zauważyć, że spowoduje to wzrost liczby kobiet chorujących na osteoporozę oraz złamań będących jej następstwem. Zwiększą się koszta medyczne i  społeczne związane z leczeniem choroby i jej następstw. Bezsprzecznie możemy stwierdzić, że wiedza na temat osteoporozy a zwłaszcza czynników jej ryzyka i profilaktyki powinien być dobrze znany środowiskom związanym z opieką zdrowotną, a przede wszystkim osobom narażonym na jej rozwój i konsekwencje. W związku z powyższym zajmowanie się tematyk

User Experience of Cognitive Behavioral Therapy Apps for Depression: An Analysis of App Functionality and User Reviews.

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Stawarz, Katarzyna; Preist, Chris; Tallon, Debbie; Wiles, Nicola; Coyle, David

2018-06-06

health and well-being. Users, including health professionals, valued and used apps that incorporated both core cognitive behavioral therapy and non-cognitive behavioral therapy elements, but concerns were also expressed regarding the unsupervised use of apps. Positivity was seen as important to engagement, for example, in the context of automatic thoughts, users expressed a preference to capture not just negative but also positive ones. Privacy, security, and trust were crucial to the user experience. Cognitive behavioral therapy apps for depression need to improve with respect to incorporating evidence-based cognitive behavioral therapy elements. Equally, a positive user experience is dependent on other design factors, including consideration of varying contexts of use. App designers should be able to clearly identify the therapeutic basis of their apps, but they should also draw on evidence-based strategies to support a positive and engaging user experience. The most effective apps are likely to strike a balance between evidence-based cognitive behavioral therapy strategies and evidence-based design strategies, including the possibility of eclectic therapeutic techniques. ©Katarzyna Stawarz, Chris Preist, Debbie Tallon, Nicola Wiles, David Coyle. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 06.06.2018.

Estimated prevalence and incidence of diagnosed ADHD and health care utilization in adults in Sweden – a longitudinal population-based register study

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Polyzoi M

2018-05-01

Full Text Available Maria Polyzoi,1 Ewa Ahnemark,2 Emma Medin,1,3 Ylva Ginsberg4,5 1PAREXEL International, Stockholm, Sweden; 2Medical Affairs Department, Shire Sweden AB, Stockholm, Sweden; 3Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; 4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 5Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden Background: Although the worldwide prevalence of attention-deficit/hyperactivity disorder (ADHD in adults is estimated to be between 2% and 5%, it is considered to be underdiagnosed. This register study explored the prevalence of diagnosed ADHD and incidence of newly diagnosed ADHD in Swedish adults over time, and assessed comorbidities and pharmacologic treatment. Methods: National Patient Register data were used to estimate the overall prevalence of adults (≥18 years with a registered ADHD diagnosis from 2006 to 2011, and the incidence of newly registered diagnoses from 2007 to 2011. Data from the Prescribed Drug Register were used to estimate the mean dose of the most frequently prescribed ADHD medication. Results: The estimated annual prevalence (N=44,364 of diagnosed ADHD increased from 0.58 per 1,000 persons in 2006 to 3.54 per 1,000 persons in 2011. The estimated annual incidence of newly diagnosed ADHD (N=24,921 increased from 0.39 per 1,000 persons to 0.90 per 1,000 persons between 2007 and 2011. At least one comorbidity was diagnosed in 52.6% of adults with ADHD (54.0% of newly diagnosed adults, with anxiety, substance use disorders, and depression being the most common. Among all adults with ADHD, 78.9% (65.7% of newly diagnosed adults were prescribed ADHD medication and one-third were prescribed more than one add-on medication. Osmotic release oral system methylphenidate was the most commonly used medication. The mean daily dose was 51.5 mg, and was

Influence of core design, production technique, and material selection on fracture behavior of yttria-stabilized tetragonal zirconia polycrystal fixed dental prostheses produced using different multilayer techniques: split-file, over-pressing, and manually built-up veneers

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Mahmood DJH

2016-02-01

Full Text Available Deyar Jallal Hadi Mahmood, Ewa H Linderoth, Ann Wennerberg, Per Vult Von Steyern Department of Prosthetic Dentistry, Faculty of Odontology, Malmö University, Malmö, Sweden Aim: To investigate and compare the fracture strength and fracture mode in eleven groups of currently, the most commonly used multilayer three-unit all-ceramic yttria-stabilized tetragonal zirconia polycrystal (Y-TZP fixed dental prostheses (FDPs with respect to the choice of core material, veneering material area, manufacturing technique, design of connectors, and radii of curvature of FDP cores. Materials and methods: A total of 110 three-unit Y-TZP FDP cores with one intermediate pontic were made. The FDP cores in groups 1–7 were made with a split-file design, veneered with manually built-up porcelain, computer-aided design-on veneers, and over-pressed veneers. Groups 8–11 consisted of FDPs with a state-of-the-art design, veneered with manually built-up porcelain. All the FDP cores were subjected to simulated aging and finally loaded to fracture. Results: There was a significant difference (P<0.05 between the core designs, but not between the different types of Y-TZP materials. The split-file designs with VITABLOCS® (1,806±165 N and e.max® ZirPress (1,854±115 N and the state-of-the-art design with VITA VM® 9 (1,849±150 N demonstrated the highest mean fracture values. Conclusion: The shape of a split-file designed all-ceramic reconstruction calls for a different dimension protocol, compared to traditionally shaped ones, as the split-file design leads to sharp approximal indentations acting as fractural impressions, thus decreasing the overall strength. The design of a framework is a crucial factor for the load bearing capacity of an all-ceramic FDP. The state-of-the-art design is preferable since the split-file designed cores call for a cross-sectional connector area at least 42% larger, to have the same load bearing capacity as the state-of-the-art designed

Assessment of the risk of falling with the use of timed up and go test in the elderly with lower extremity osteoarthritis

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Zasadzka E

2015-08-01

Full Text Available Ewa Zasadzka,1 Adrianna Maria Borowicz,1 Magdalena Roszak,2 Mariola Pawlaczyk1 1Department of Geriatric Medicine and Gerontology, Karol Marcinkowski University of Medical Sciences, 2Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland Background: Falling in the elderly results in a significant number of admissions to hospitals and long-term care facilities, especially among patients with lower extremity osteoarthritis (OA.Objective: The aim of the study was to assess the risk of falling in adults older than 60 years with OA using timed up and go (TUG test.Materials and methods: A total of 187 patients (aged >60 years were enrolled in the study. The assessment included: basic activities of daily living (ADLs, lower extremity strength with the use of the 30-second chair stand test (30 CST, and assessment of the risk of falling (TUG test. Pain intensity was evaluated with the numeric rating scale (NRS.Results: The TUG test results were significantly better in younger OA patients (aged 60–69 years, as compared with their older peers (aged 70–79 years; P<0.01 and the oldest group (aged >80 years; P<0.001. Also, the 30 CST results were significantly higher in younger OA patients (P<0.05. Subjects older than 80 years had a significantly worse ADL score (P<0.05 and P<0.001. Pain complaints were reported significantly more frequently by women than men (P<0.05. A correlation between age and the TUG test score (r=0.412; P<0.0004 as well as between the TUG test and the 30 CST scores (r=0.7368; P=0.000 was detected. In the group with the TUG test score of <13.5 seconds, the 30 CST (P<0.0001 and ADL (P<0.003 results were significantly better. A comparison of fallers vs nonfallers revealed that the number of falls was significantly higher in the group of subjects who scored $13.5 when compared to <13.5 (P=0.003. Fallers significantly more often reported pain (P<0.0001, whereas nonfallers had

Clinical importance of serum HE4 and MMP2 levels in endometrial cancer patients

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Cymbaluk-Ploska A

2017-06-01

Full Text Available Aneta Cymbaluk-Płoska,1 Anita Chudecka-Głaz,1 Ewa Pius-Sadowska,2 Agnieszka Sompolska-Rzechuła,3 Bogusław Machaliński,2 Anna Surowiec,1 Janusz Menkiszak1 1Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, 2Department of General Pathology, Pomeranian Medical University, 3Department of Statistics, West Pomeranian University of Technology, Szczecin, Poland Introduction: Endometrial cancer is the one of the most common cancers of the genital organ. HE4 and MMP2 are both proteins whose serum levels increase in endometrial cancer.Aim: To explore the diagnostic potential of the serum levels of HE4 and MMP2 in patients with endometrial cancer and benign endometrial diseases. To assess the relationship between the serum levels of HE4 and MMP2 and the typical prognostic factors in patients with endometrial cancer.Materials and methods: Included in the study was a group of 112 patients presenting with bleeding abnormalities at the Pomeranian Medical University in years 2012–2016. Serum HE4 concentrations were measured using the Elecsys Electrochemiluminescence Immunoassay (ECLIA. MMP2 concentrations were quantified in the serum using multiplex immunoassays.Results: We observed statistically significant differences in mean serum levels of HE4 and MMP2 between the group of endometrial cancer patients and the group of patients with no changes in the endometrium (P=0.002/0.003. The diagnostic potential of HE4 and MMP2 in differentiation of high (International Federation of Gynecology and Obstetrics [FIGO] III and IV vs low (FIGO I and II clinical stage of tumor and prediction of cellular differentiation grade (G1 vs G3 on the basis of the analysis of the area under the curve is, respectively, 0.86 and 0.82 for HE4 and 0.82 and 0.74 for MMP2. The HE4 marker was significantly more specific than MMP2 in every study group and amounted to 93% vs 86% in all patients included in the analysis, 94% vs 84% in pre

Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

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Cymbaluk-Płoska A

2018-03-01

Full Text Available Aneta Cymbaluk-Płoska,1 Anita Chudecka-Głaz,1 Anna Jagodzińska,1 Ewa Pius-Sadowska,2 Agnieszka Sompolska-Rzechuła,3 Bogusław Machaliński,2 Janusz Menkiszak1 1Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland; 2General Pathology Department, Pomeranian Medical University, Szczecin, Poland; 3Department of Statistics, West Pomeranian University of Technology, Szczecin, Poland Introduction: Adipose tissue is considered an endocrine organ and produces a number of biologically active substances. Aims: To consider the role that four adipokines – leptin, omentin-1, vaspin, and galectin-3 – play in the diagnosis of endometrium cancer and to investigate the association between serum concentrations of adipose tissue metabolism products and the diagnostics and prognosis in endometrial cancer. Patients and methods: The study included 168 patients with body mass index (BMI >20 kg/m2 admitted due to post-menopausal bleeding. Results: A receiver operating characteristic curves test was performed to determine the diagnostic values of the proteins tested. For leptin and galectin-3 the area under the curve (AUC values were 0.79/0.68, while for vaspin and omentin-1 the AUC values were 0.82/0.86 for all study patients. The final model identified the following independent risk factors: glucose concentration, BMI, waist circumference, leptin, and vaspin concentrations. Diagnostic values of leptin and galectin-3 with regard to differentiation between high (Fédération Internationale de Gynécologie Obstétrique [FIGO] III and IV and low (FIGO I and II stages of clinical tumor advancement and prediction of tumor grading (G1 vs G3 based on the AUC curve were 0.82/0.70 and 0.80/0.74. The AUC values for vaspin and omentin-1 with respect to differentiation between histopathological advancement and grading were 0.86/0.81 and 0.83/0.77, respectively. Significantly lower values of

Motywacja i wpływ uprawiania jogi na stan zdrowia – badanie własne = Motivation and influence practicing yoga on health - own study

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Katarzyna Gwis

2016-09-01

  Motywacja i wpływ uprawiania jogi na stan zdrowia – badanie własne Motivation and influence practicing yoga on health - own study   Katarzyna Gwis1, Dominik Olejniczak2, Joanna Skonieczna2   1 Absolwentka kierunku Zdrowie Publiczne Wydział Nauki o Zdrowiu Warszawski Uniwersytet Medyczny   2 Warszawski Uniwersytet Medyczny Zakład Zdrowia Publicznego ul. Banacha 1a, 02-097 Warszawa   Słowa kluczowe: joga, zdrowie, zachowania zdrowotne Key words: yoga, health, health behavior   Streszczenie Wprowadzenie i cel pracy: Joga to jedna z form aktywności ruchowej. Joga oddziałuje na ciało i na umysł, dzięki czemu w prosty sposób pomaga zachować zdrowie. Celem badania była ocena wpływu uczestnictwa w zajęciach jogi na zdrowie. Materiał i metoda: Grupę badaną stanowiło 50 osób uczęszczających na zajęcia jogi. Udział w ankiecie był dobrowolny i poufny. Zastosowano autorski kwestionariusz. Wyniki: W grupie badanych, aż 48 osób (96% stwierdziło, że ćwiczenia jogi pozytywnie wpływają na kształtowanie nawyków ruchowych. Ponad połowa badanych - 26 osób (52% stwierdziła, że uczęszczanie na zajęcia jogi sprawiło, że wzrosło ich zainteresowanie zdrowym odżywianiem. Ponad połowa badanych – 26 osób (52% jako główną korzyść płynącą z ćwiczeń jogi wskazała wzrost sprawności fizycznej. Ponad połowa osób ankietowanych – 28 osób (56% zaobserwowała, że od kiedy ćwiczy jogę stany chorobowe występują rzadziej.  Wnioski: Analizując wyniki przeprowadzonego badania własnego oraz dyskusję można stwierdzić, iż w związku z udokumentowanym pozytywnym wpływem jogi na stan zdrowia warto jest propagować tą formę rekreacji ruchowej we wszystkich grupach wiekowych, poczynając od dzieci, a  kończąc na osobach w  podeszłym wieku.       Abstract   Introduction: Yoga is a form of physical activity. Yoga affects the body and the mind, making it an easy way to help maintain good health. The aim of this

PLASMA-2013: International Conference on Research and Applications of Plasmas (Warsaw, Poland, 2-6 September 2013)

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Sadowski, Marek J.

2014-05-01

, Otwock, Poland—Chairman Dimitri Batani, Universite Bordeaux, France Sergio Ciattaglia, ITER, Cadarache, France Michael Dudeck, UPMC, Paris, France Igor E Garkusha, NSC KIPT, Kharkov, Ukraine Zbigniew Kłos, CBK PAN, Warsaw Giorgio Maddaluno, ENEA Frascati, Italy Andrea Murari, EFDA JET, Culham, UK Józef Musielok, University of Opole, Poland Svetlana Ratynskaia, RIT, Stockholm, Sweden Karel Rohlena, IP CAS, Prague, Czech Republic Valentin Smirnov, Rosatom, Moscow, Russia Francisco Tabares, CIEMAT, Madrid, Spain Lorenzo Torrisi, University of Messina, Messina, Italy Jerzy Wołowski, IFPiLM, Warsaw, Poland Urszula Woźnicka, IFJ PAN, Cracow, Poland Local Organizing Committee Jerzy Wołowski—Chairman Paweł Gąsior—Secretary Zofia Kalinowska Ewa Kowalska-Strzęciwilk Monika Kubkowska Anita Pokorska Ryszard Panfil Joanna Dziak-Beme Conference website: http://plasma2013.ipplm.pl/

Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy

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Allen RH

2013-01-01

Full Text Available John J Kim,1,2 Nathan Buchbinder,1,† Simon Ammanuel,1,4,5,† Robert Kim,1,† Erika Moore,1 Neil O'Donnell,1 Jennifer K Lee,3 Ewa Kulikowicz,3 Soumyadipta Acharya,1 Robert H Allen,1,9 Ryan W Lee,6,7 Michael V Johnston4–81Department of Biomedical Engineering, Whiting School of Engineering, The Johns Hopkins University, 2The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, 3Department of Anesthesia and Critical Care Medicine, Johns Hopkins University, 4Kennedy Krieger Institute, 5Hugo W Moser Research Institute, 6Department of Neurology, 7Department of Pediatrics, 8Department of Physical Medicine and Rehabilitation Johns Hopkins University School of Medicine, Baltimore, MD; 9Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA†These authors contributed equally to this workAbstract: Despite recent advances in neonatal care and monitoring, asphyxia globally accounts for 23% of the 4 million annual deaths of newborns, and leads to hypoxic-ischemic encephalopathy (HIE. Occurring in five of 1000 live-born infants globally and even more in developing countries, HIE is a serious problem that causes death in 25%–50% of affected neonates and neurological disability to at least 25% of survivors. In order to prevent the damage caused by HIE, our invention provides an effective whole-body cooling of the neonates by utilizing evaporation and an endothermic reaction. Our device is composed of basic electronics, clay pots, sand, and urea-based instant cold pack powder. A larger clay pot, lined with nearly 5 cm of sand, contains a smaller pot, where the neonate will be placed for therapeutic treatment. When the sand is mixed with instant cold pack urea powder and wetted with water, the device can extract heat from inside to outside and maintain the inner pot at 17°C for more than 24 hours with monitoring by LED lights and thermistors

Do prescrito ao real: a gestão individual e coletiva dos trabalhadores de enfermagem frente ao risco de acidente de trabalho From prescribed to real: the collective and individual management of nursing workers toward the risk of workplace accidents

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Davidson Passos Mendes

2012-12-01

Full Text Available Esse artigo tem por objetivo levantar os constrangimentos enfrentados pelos auxiliares e técnicos de enfermagem (AeTE de uma instituição pediátrica, vinculada a uma fundação estatal, em sua atividade de trabalho e identificar estratégias utilizadas por eles que garantam as metas de produção, a satisfação do trabalhador e a sua autoproteção contra os acidentes de trabalho. Por meio do método da AET, foram utilizados para análise e coleta de dados 34 trabalhadores de enfermagem - nível médio e técnico -, entre efetivos e contratados e, observadas as estratégias de ação e regulação destes trabalhadores frente às interfaces com que lidam. Os resultados mostram que entre os constrangimentos levantados nesta Instituição, os mais evidentes são: a dupla jornada de trabalho, a diversidade de vínculos empregatícios, os riscos a que estes profissionais estão expostos e o não conhecimento do objeto de trabalho. Verifica-se que esses constrangimentos ocasionam uma elevação das cargas de trabalho física, psíquica e cognitiva. Visando reduzir essas cargas de trabalho, o trabalhador tenta criar estratégias que são adquiridas por meio da vivência com o trabalho, das experiências e valores, para se regular frente ao risco no trabalho.The objective of this study is to analyze the constraints faced by the nursing assistants and technicians in a pediatric clinic sponsored by a state foundation during their work activities and identify the strategies adopted by them in order to guarantee the achievement of their production goals and job satisfaction and ensure their protection against workplace accidents. The method of Ergonomic Work Analysis (EWA was used for analysis and data collection of 59 tenured and temporary nursing workers with intermediate and technical level of education and to investigate the strategies related to actions and employment regulation concerning the interfaces they deal with. The results show that among

Akceptacja choroby kobiet leczących się z powodu osteoporozy = Acceptance of diseases of women treated for osteoporosis

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Katarzyna Pawlikowska-Łagód

2016-05-01

  mgr Pawlikowska-Łagód Katarzyna, dr n. o zdr. Janiszewska Mariola, mgr Firlej Ewelina, Dąbska Olga, dr hab. n med. Sak Jarosław     Abstrakt Wprowadzenie: Współczesna medycyna oraz psychologia coraz więcej czasu poświęcają problemom związanym z osteoporozą oraz przystosowaniu się do niej. Przystosowanie się i akceptacja osteoporozy to skomplikowany proces, na, który wpływają obciążenia chorobowe, uwarunkowania zewnętrzne oraz właściwości jednostki. Akceptacja choroby dla wielu pacjentek jest problemem, z którym zmagają się przez cały okres jej trwania, zmuszając je do akceptacji niedomagań przez nią narzuconych choroby. Pojawienie się choroby ma duże znaczenie, dla jakości życia kobiet. Przede wszystkim zmuszając je do akceptacji niedomagań narzuconych przez chorobę. Cel pracy: Celem pracy było zbadanie stopnia akceptacji choroby kobiet chorujących na osteoporozę. Materiał i metody: W badaniu uczestniczyło 137 pacjentek leczących się z powodu osteoporozy. Grupę badaną stanowiły kobiety od 38-go do 91-g roku życia. Badania przeprowadzono od lutego do kwietnia 2015 roku. W pracy zastosowano kwestionariusz ankiety własnego autorstwa oraz Skalę Akceptacji Choroby (AIS autorstwa B. J. Felton, T. A. Revenson i G. A. Hinrichsen w adaptacji Z Jurczyńskiego. Wyniki: Kobiety chorujące na osteoporozę wykazują się średnim stopniem akceptacji choroby. Wiek zdiagnozowania choroby oraz wykształcenie różnicuje istotnie badane ze względu na stopień akceptacji choroby oraz problemów narzuconych przez chorobę. Wnioski: Rosnąca liczba osób chorych z powodu osteoporozy stawia przed specjalistami służby zdrowia ogromne wyzwanie. Wdrożenie skutecznych programów profilaktycznych oraz oddziaływanie na zwiększenie świadomości chorujących byłoby pomocne w zapobieganiu chorobie, ewentualnie jej akceptacji w sytuacji wystąpienia.   Abstract Introduction: Modern medicine and psychology more and spend more time

Pracoholizm w kategoriach deprecjacji pracy pielęgniarki. Wybrane aspekty = Workaholism in categories of nurses’ work depreciation. Chosen aspects

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Ewa Stychno

2016-10-01

Stychno Ewa, Kulczycka Kinga   Katedra i Zakład Zarządzania w Pielęgniarstwie, Wydział Nauk o Zdrowiu UM w Lublinie Chair and Department of Management in Nursing Faculty Health Sciences Medical University of Lublin       Słowa kluczowe: pielęgniarki, pracoholizm, stres, wypalenie zawodowe Keys words: nurses, workaholism, stress, occupational burnout syndrome       Streszczenie Pracoholizm jest zjawiskiem badanym przede wszystkim przez psychologów, którzy koncentrują się na relacjach pracoholika z bliskimi mu osobami. Ale skutki tego uzależnienia ujawniają się także w funkcjonowaniu pielęgniarki w środowisku pracy. Pielęgniarstwo należy do zawodów, w których ciągły stres jest nieodłącznym aspektem, wynikającym z natury pracy. Niewłaściwe radzenie sobie ze stresem w sytuacjach trudnych prowadzi do powstania zespołu wypalenia zawodowego. Dlatego zagadnienie to powinno stanowić obszar poszukiwań badawczych także dla kadry zarządzającej kapitałem ludzkim. Cel pracy Celem niniejszego opracowania jest omówienie pracoholizmu i jego negatywnych skutków (stres i wypalenie zawodowe w kategoriach deprecjacji pracy pielęgniarki. Pracoholizm zaburza równowagę pomiędzy pracą zawodową a życiem prywatnym. Ograniczeniu ulega zaangażowanie pracownika w życie rodzinne, brakuje czasu na realizację własnych zainteresowań. Sytuacja taka powoduje stres i zjawisko wypalenia zawodowego, a w także negatywne konsekwencje dla jednostki, jak i jej najbliższego otoczenia. Narastające trudności związane z wykonywaną pracą, stała rywalizacja, niepewność zatrudnienia będą potęgowały negatywny aspekt pracoholizmu i osłabiały mechanizmy przystosowawcze.  Wnioski Konieczne jest uświadomienie sobie przez kadrę zarządzającą faktu, iż pracownicy - pracoholicy nie przynoszą organizacji tylu korzyści, co pracownicy posiadający umiejętność panowania nad własnym życiem, pracą i rodziną.   Summary Workaholism is a

Ocena potrzeb zdrowotnych nauczycieli szkół średnich w kontekście zagrożeń zdrowia związanych z miejscem pracy = Assessment of the health needs of secondary school teachers in the context of health risks at the workplace

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Katarzyna Wodzyńska

2016-05-01

2Szkoła Główna Handlowa, Kolegium Ekonomiczno-Społeczne, ul. Wiśniowa 41, 02-520 Warszawa   mgr Katarzyna Wodzyńska mgr Joanna Skonieczna dr n. med. Dominik Olejniczak dr n. o zdr. Urszula Religioni   Słowa kluczowe: potrzeba zdrowotna, nauczyciele, promocja zdrowia, miejsce pracy Key words: need care, teachers, health promotion, workplace   Streszczenie Wstęp Nauczyciel w swoim zawodzie narażony jest na wiele niekorzystnych czynników. Miejsce pracy oraz warunki jakie w nim panują, w znacznym stopniu wpływają na zdrowie i samopoczucie. Odpowiednia ergonomia stanowiska pracy jest w tej kwestii bardzo istotna. Głównym celem pracy jest zbadanie i ocena potrzeb zdrowotnych nauczycieli, które są związane z charakterem, miejscem wykonywanej  pracy oraz występujących w niej zagrożeń zdrowia. Materiał i metody W przeprowadzonym badaniu ankietowym, dotyczącym wykonywania zawodu nauczyciela wzięło udział 283 nauczycieli z dwunastu  szkół średnich znajdujących się na terenie województwa mazowieckiego. Wypełniony przez nauczycieli kwestionariusz składał się z 21 pytań dotyczących zagadnień związanych z wykonywaniem zawodu. Uzyskane wyniki poddano analizie statystycznej z wykorzystaniem testu Chi2 Pearsona oraz R Spearmana. Za istotne różnice uznano te, dla których prawdopodobieństwo p<0.05. Wyniki Blisko połowa respondentów wskazała, że praca ma istotny wpływ na zdrowie. Według 20,5% badanych wykonywany zawód w średnim stopniu wpływa na stan zdrowia, zaś 18% wszystkich respondentów uważa, że udział czynników pracy w ogólnym samopoczuciu jest niewielki. Zmęczenie jest jedną z najczęstszych dolegliwości wśród nauczycieli. 18,1% badanych deklaruje że odczuwa je codziennie, zaś u 39,7% respondentów występuje ono często, bo 2-3 razy w tygodniu. Wnioski Uzyskane wyniki pozwalają wyciągnąć wniosek, iż nauczyciele mają świadomość wpływu pracy na zdrowie, jak również są świadomi dolegliwo

Różnice deklarowanej częstości samokontroli stanu zdrowia u osób pracujących w zawodach medycznych i pozamedycznych = The difference between the declared frequency of self-health monitoring carried out by representatives of the medical and the non-medical professions

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Grzegorz Józef Nowicki

2016-05-01

3. Katedra i Zakład Pielęgniarstwa Pediatrycznego, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie     dr n. o zdrowiu Grzegorz Józef Nowicki1, dr hab. n. med. Ewa Rudnicka-Drożak2, dr hab. n. o zdrowiu Barbara Ślusarska1, mgr Honorata Piasecka1, dr hab. n. o zdrowiu Danuta Zarzycka3, mgr Magdalena Brodowicz-Król3   1. Zakład Medycyny Rodzinnej i Pielęgniarstwa Środowiskowego, Katedra Onkologii i Środowiskowej Opieki Zdrowotnej, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie 2. Przychodnia Lekarza Rodzinnego, CRH ŻagielMed, ul. Onyksowa 12, 20-582 Lublin 3. Katedra i Zakład Pielęgniarstwa Pediatrycznego, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie     Słowa klucze: profilaktyka, zachowania kontroli zdrowia, osoby pracujące Key words: prevention, behavior health checks, people working   Streszczenie Wstęp: Uczestnictwo w populacyjnych badaniach profilaktycznych oraz regularne samobadanie narządów to zachowania zdrowotne zmierzające do wczesnego wykrycia chorób. Cel pracy: Określenie różnic w zakresie deklarowanej samokontroli stanu zdrowia (uczestnictwo w programach profilaktyki i samobadania narządów pomiędzy osobami wykonującymi zawód medyczny i pozamedyczny. Materiał i metody: Badania przeprowadzono wśród 598 dorosłych osób pracujących, wykonujących zawody medyczne i pozamedyczne. Narzędziem badawczym był kwestionariusz ankiety własnego autorstwa. Wyniki: Uzyskane wyniki badań wskazują, że osoby wykonujące zawód niemedyczny istotnie częściej deklarowały uczestnictwo w Ogólnopolskim Programie Profilaktyki Chorób Odtytoniowych (w tym POChP oraz w Ogólnopolskim Programie Profilaktyki Raka Jelita (p<0,001 niż badani wykonujący zawód medyczny. Natomiast kobiety, które wykonywały zawód medyczny, istotnie częściej deklarowały uczestnictwo w Ogólnopolskim Programie Profilaktyki Raka Szyjki Macicy oraz częściej wykonywały  samobadanie piersi. (p<0,001. Wnioski: Istnieje

PREFACE: Quantum dots as probes in biology

Science.gov (United States)

Cieplak, Marek

2013-05-01

photosynthetic systems. The next paper, by Olejnik et al, discussed metallic QDs which enhance photosynthetic function in light-harvesting biomolecular complexes. Such hybrid structures with gold QDs are shown to exhibit a strong increase in the fluorescence quantum yield. The next two papers, by Sikora et al and Kaminska et al deal with the ZnO nanoparticles passivated by MgO. In the first of these two papers, the authors describe the behavior of ZnO/MgO when introduced to human cancer cells. In the second, the authors describe the QDs with an extra outer layer of Fe2O3 which makes the nanoparticles superparamagnetic and also capable of generation of reactive oxygen species which could be applied to form localized centers of toxicity for cancer treatment. Finally, in the last paper by Yatsunenko et al, the authors discuss several semiconducting QDs like ZnO with various rare-earth dopands. They propose a microwave-driven hydrothermal technology to make them, characterize their luminescence and demonstrate their usefulness in the early recognition of cancer tissues. Quantum dots as probes in biology contents Quantum dots as probes in biologyMarek Cieplak Luminescent nanoparticles and their applications in the life sciencesVarun K A Sreenivasan, Andrei V Zvyagin and Ewa M Goldys Ferredoxin:NADP+ oxidoreductase in junction with CdSe/ZnS quantum dots: characteristics of an enzymatically active nanohybrid Krzysztof Szczepaniak, Remigiusz Worch and Joanna Grzyb Spectroscopic studies of plasmon coupling between photosynthetic complexes and metallic quantum dotsMaria Olejnik, Bartosz Krajnik, Dorota Kowalska, Guanhua Lin and Sebastian Mackowski Luminescence of colloidal ZnO nanoparticles synthesized in alcohols and biological application of ZnO passivated by MgOBożena Sikora, Krzysztof Fronc, Izabela Kamińska, Kamil Koper, Piotr Stępień and Danek Elbaum Novel ZnO/MgO/Fe2O3 composite optomagnetic nanoparticles I Kamińska, B Sikora, K Fronc, P Dziawa, K Sobczak, R Minikayev, W

A revision of the family Ameroseiidae (Acari, Mesostigmata), with some data on Slovak fauna

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Mašán, Peter

2017-01-01

, 1918 = Kleemannia plumosa (Oudemans, 1902); Ameroseius eumorphus Bregetova, 1977 and Kleemannia potchefstroomensis Kruger & Loots, 1980 = Kleemannia pseudoplumosa (Rack, 1972); Ameroseius gilarovi Petrova, 1986 = Kleemannia plumigera Oudemans, 1930; Ameroseius imparsetosus Westerboer, 1963 = Ameroseius georgei (Turk, 1943); Ameroseius lanatus Solomon, 1969 and Ameroseius fimetorum Karg, 1971 = Kleemannia tenella (Berlese, 1916); Ameroseius lanceosetis Livshits & Mitrofanov, 1975 = Kleemannia pavida (C. L. Koch, 1839); Ameroseius marginalis Fan & Li, 1993 and Ameroseius sichuanensis Fan & Li, 1993 = Kleemannia insignis (Bernhard, 1963); Ameroseius pseudofurcatus Livshits & Mitrofanov, 1975 = Ameroseius furcatus Karg, 1971; Ameroseius stramenis Karg, 1976 and Lasioseius (Lasioseius) gracilis Halbert, 1923 = Kleemannia delicata (Berlese, 1918); Epicriopsis langei Livshits & Mitrofanov, 1975 and Epicriopsis baloghi Kandil, 1978 = Epicriopsis palustris Karg, 1971; Epicriopsis rivus Karg, 1971 = Epicriopsis mirabilis Willmann, 1956; Neocypholaelaps ewae Haitlinger, 1987 = Neocypholaelaps indicus Evans, 1963; Neocypholaelaps lindquisti Prasad, 1968, Afrocypholaelaps ranomafanaensis Haitlinger, 1987 and Afrocypholaelaps analicullus Ho, Ma, Wang & Severinghaus, 2010 = Afrocypholaelaps africanus (Evans, 1963); Sinoseius pinnatus Huhta & Karg, 2010 = Sinoseius lobatus Bai, Gu & Fang, 1995. Ameroseius womersleyi Mašán, is a replacement name proposed for Ameroseius ornatus Womersley, 1956, a junior secondary homonym of Cornubia ornata Turk, 1943 [= Ameroseius corbiculus (Sowerby, 1806)]. Cornubia georgei Turk, 1943 is removed from synonymy with Ameroseius corbiculus (Sowerby, 1806). An annotated catalogue of the world species of Ameroseiidae is provided, partly based on type (in more than 60 species) and non-type specimens from various museum deposits and personal collections, including new or revised material from Slovakia. It contains 206 named species (138 valid species, 37

A revision of the family Ameroseiidae (Acari, Mesostigmata, with some data on Slovak fauna

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Peter Mašán

2017-09-01

, 1918 = Kleemannia plumosa (Oudemans, 1902; Ameroseius eumorphus Bregetova, 1977 and Kleemannia potchefstroomensis Kruger & Loots, 1980 = Kleemannia pseudoplumosa (Rack, 1972; Ameroseius gilarovi Petrova, 1986 = Kleemannia plumigera Oudemans, 1930; Ameroseius imparsetosus Westerboer, 1963 = Ameroseius georgei (Turk, 1943; Ameroseius lanatus Solomon, 1969 and Ameroseius fimetorum Karg, 1971 = Kleemannia tenella (Berlese, 1916; Ameroseius lanceosetis Livshits & Mitrofanov, 1975 = Kleemannia pavida (C. L. Koch, 1839; Ameroseius marginalis Fan & Li, 1993 and Ameroseius sichuanensis Fan & Li, 1993 = Kleemannia insignis (Bernhard, 1963; Ameroseius pseudofurcatus Livshits & Mitrofanov, 1975 = Ameroseius furcatus Karg, 1971; Ameroseius stramenis Karg, 1976 and Lasioseius (Lasioseius gracilis Halbert, 1923 = Kleemannia delicata (Berlese, 1918; Epicriopsis langei Livshits & Mitrofanov, 1975 and Epicriopsis baloghi Kandil, 1978 = Epicriopsis palustris Karg, 1971; Epicriopsis rivus Karg, 1971 = Epicriopsis mirabilis Willmann, 1956; Neocypholaelaps ewae Haitlinger, 1987 = Neocypholaelaps indicus Evans, 1963; Neocypholaelaps lindquisti Prasad, 1968, Afrocypholaelaps ranomafanaensis Haitlinger, 1987 and Afrocypholaelaps analicullus Ho, Ma, Wang & Severinghaus, 2010 = Afrocypholaelaps africanus (Evans, 1963; Sinoseius pinnatus Huhta & Karg, 2010 = Sinoseius lobatus Bai, Gu & Fang, 1995. Ameroseius womersleyi Mašán, is a replacement name proposed for Ameroseius ornatus Womersley, 1956, a junior secondary homonym of Cornubia ornata Turk, 1943 [= Ameroseius corbiculus (Sowerby, 1806]. Cornubia georgei Turk, 1943 is removed from synonymy with Ameroseius corbiculus (Sowerby, 1806. An annotated catalogue of the world species of Ameroseiidae is provided, partly based on type (in more than 60 species and non-type specimens from various museum deposits and personal collections, including new or revised material from Slovakia. It contains 206 named species (138 valid species, 37 synonyms, nine

[The herbals and floristic albums of Eliza Orzeszkowa].

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Kuźnicka, Barbara

2006-01-01

In many of her literary works, the writer and columnist Eliza Orzeszkowa (1841-1910), who was twice nominated for the Nobel Prize in literature (1905, 1909), depicted the life of the Polish society in the eastern lands of the former Polish-Lithuanian Commonwealth in the second half of the 19th century. A great lover of nature, Orzeszkowa appreciated the botanical knowledge of the local rural population in the vicinities of Grodno. She combined attempts to master that knowledge with her other great passion, that of investigating folk culture, and was always ready to listen to what women who were village herbalists had to tell her about medicinal plants, and about the customs and legends connected with the medical practices based on herbal remedies. She then passed on the information to botanists for scientific verification. Orzeszkowa's naturalist and ethnographic fascinations led her to write a cycle of articles on "The people and flowers on the Niemen river", published in 1888-1891 in the ethnographic-tourist magazine "Wisła". This collection of articles has been analysed not only by historians of literature, but also, since 1985, by historians of science. The first analysis was conducted at the Section for the History of Pharmacy of the Institute of the History of Science of the Polish Academy of Sciences. This yielded Ewa Kamińska's study: Ziołoznawstwo i ziołolecznictwo w publikacjach etnograficznych Elizy Orzeszkowej [The knowledge of herbs and medicine based on herbal remedies in the ethnographic publications of Eliza Orzeszkowa] published as part of the Institute's Historia leków naturalnych [History of natural medicines], ed. Barbara Kuźnicka, vol. I: Zródła do dziejów etnofarmacji polskiej [Sources for the history of Polish ethnopharmacy], Warszawa 1996, pp.25-88. The subject-matter of the publication aroused much interest among historians of pharmacy from Poznań. The first sign of that interest could be seen in the article by Jan Majewski and S�

Introduction

International Nuclear Information System (INIS)

Rusek, K.

2011-01-01

, the 17 th Nuclear Physics Workshop '' Marie (and) Pierre Curie ''. The general subject was '' Symmetry and symmetry breaking in nuclear physics ''. The conference took place in Kazimierz Dolny, from 22 nd till 26 th of September and attracted about seventy scientists from various countries. Our PhD students are among the best at the University of Warsaw. Katarzyna Hadynska-Klek was awarded a prestigious research scholarship funded by the European Social Fund in the framework of the Human Capital Programme. The greatest news came at the end of the year - our project '' Purchase and installation of two HF generators for the Warsaw U-200P cyclotron '' obtained full funding from the MNiSW. Thus, by the end of 2013 we should have exchanged our very old and worn out generators by new ones. After almost twenty years of constant activity this message brings a new lease of life to our laboratory. (author)

Następstwa zdrowotne pracy w narażeniu na leki cytostatyczne w grupie zawodowej pielęgniarek i pielęgniarzy = The health consequences of occupational exposure to cytostatics among nurses

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Agnieszka Cieślicka

2016-09-01

Agnieszka Cieślicka1, Magda Gębka2, Marcin Rząca3, Katarzyna Kocka4, Agata Pietraszek3, Agnieszka Bartoszek4, Marianna Charzyńska-Gula5   1. Blok Operacyjny, Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie 2. Oddział Chirurgii Naczyniowej, Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego w Lublinie 3. Zakład Onkologii, Katedra Onkologii i Środowiskowej Opieki Zdrowotnej, Uniwersytet Medyczny w Lublinie 4. Zakład Medycyny Rodzinnej i Pielęgniarstwa Środowiskowego, Katedra Onkologii i Środowiskowej Opieki Zdrowotnej, Uniwersytet Medyczny w Lublinie 5. Wydział Nauk Społecznych i Humanistycznych, Państwowa Wyższa Szkoła im. prof. Stanisława Tarnowskiego w Tarnobrzegu   Streszczenie Wprowadzenie. Stosowane w leczeniu przeciwnowotworowym leki cytostatyczne działają toksycznie nie tylko na komórki nowotworowe, ale także na zdrowe. Przyjęcie chemioterapii wiąże się z występowaniem u pacjentów licznych, mocno nasilonych objawów niepożądanych. Kontakt z tymi lekami ma także personel. Toksyczne cytostatyki są wchłaniane przez personel drogą wziewną, kontaktową przez skórę, co ma miejsce nie tylko podczas przygotowywania i podawania leków przez personel pielęgniarski ale także przez kontakt z wydzielinami pacjentów. Ich wpływ na zdrowie pielęgniarek i pielęgniarzy nie jest obojętny. Cel. Celem badań było zbadanie następstw zdrowotnych pracy w narażeniu na leki cytostatyczne w grupie zawodowej pielęgniarek i pielęgniarzy. Materiał i metody. Uczestnikami badania były pielęgniarki i pielęgniarze lubelskich szpitali w liczbie 97 osób, podający pacjentom i/lub przygotowujący leki cytostatyczne. Narzędzia badawczym był autorski kwestionariusz ankiety, składający się z 14 pytań. Wyniki. Personel pielęgniarski pracujący w narażeniu na leki cytostatyczne obserwował u siebie następujące objawy: nadmierne łzawienie, suchość spojówek, zaczerwienienie i swędzenie oczu (47%, podra

Nadwaga i otyłość a niedoczynność tarczycy = Overweight and obesity in hypothyroidism

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Katarzyna Szwajkosz

2016-07-01

  Korespondencja: Katarzyna Szwajkosz Katedra Interny z Zakładem Pielęgniarstwa Internistycznego, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Lublinie ul. Jaczewskiego 8, 20-954 Lublin tel. 81 742 58 25 kszwajkosz@wp.pl           Streszczenie Wstęp. Niedoczynność tarczycy, najczęściej będąca skutkiem przewlekłego autoimmunologicznego zapalenia, jest jedną z najczęstszych patologii gruczołu tarczowego i dotyczy około 2% populacji. Niedobór hormonów tarczycy manifestuje się zwykle zmniejszeniem napędu życiowego, stanami depresyjnymi, pogorszeniem sprawności intelektualnej, nietolerancją niższych temperatur. Patologia ta wiąże się ze zwiększonym ryzykiem  nadwagi lub otyłości, wtórnie do zwolnionego metabolizmu, a także jest czynnikiem sprzyjającym hiperlipidemii, co wiąże się ze wzrostem ryzyka sercowo-naczyniowego. Celem pracy była ocena występowania nadwagi i otyłości w grupie pacjentów z niedoczynnością tarczycy. Materiał i metody. W badaniu wzięło udział 101 pacjentów (77K, 24M, w wieku średnio 43 lat z rozpoznaną niedoczynnością tarczycy. W toku badań zastosowano metodę sondażu diagnostycznego z wykorzystaniem autorskiego kwestionariusza ankiety oraz metodę pomiaru parametrów antropometrycznych, w tym BMI, obwodu talii i bioder. Wyniki. Wśród badanych pacjentów nadwagę (BMI 25-29,9 miało 39,6% badanych, otyłość I stopnia (BMI 30-34,9 26,7% pacjentów, otyłość II stopnia (BMI 35-29,9- 10,9%. Wartości BMI≥40 cechujące otyłość III stopnia stwierdzono u 2% badanych. Średnia wartość BMI wyniosła 28,9, przy czym pacjenci w wieku 18-25 lat istotnie częściej cechowali się prawidłową masą ciała niż badani w grupie wiekowej ≥65 lat (p=0,0003, podobnie pacjenci wieku 26-40 lat w porównaniu z badanymi ≥65 lat (p=0,001.  Wnioski. Nadwaga i otyłość dotyczą większości pacjentów z niedoczynnością tarczycy, a ryzyko to rośnie wraz z wiekiem. Wartym rozważenia jest

Ocena nawyków higienicznych u młodzieży w wieku licealnym = The rating of hygiene habits in people of secondary school age

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Dominik Olejniczak

2015-08-01

Dominik Olejniczak1, Katarzyna Taraś2, Urszula Religioni1, Aleksandra Czerw1   1Warszawski Uniwersytet Medyczny    Katedra i Zakład Zdrowia Publicznego    ul. Banacha 1a,    02-097 Warszawa   2Studenckie Koło Naukowe Zdrowia Publicznego    Warszawski Uniwersytet Medyczny    Katedra i Zakład Zdrowia Publicznego    ul. Banacha 1a,    02-097 Warszawa   Adres do korespondencji: Dominik Olejniczak Warszawski Uniwersytet Medyczny Katedra i Zakład Zdrowia Publicznego ul. Banacha 1a, 02-097 Warszawa   dominikolejniczak@op.pl Tel: 22 599 21 80 Fax: 22 599 21 81   Streszczenie   Wprowadzenie Dbanie o higienę jest istotnym elementem w życiu człowieka. Pozwala zachować zdrowie oraz zmniejsza ryzyko występowania niektórych chorób. Już od najmłodszych lat człowiek uczy się podstawowych czynności higienicznych. Z upływem lat dbanie o higienę rąk, twarzy i ciała staje się bardziej istotne. Materiał i metoda W badaniu wzięło udział 417 licealistów, w tym 226 kobiet i 191 mężczyzn. Wszyscy respondenci byli w wieku 17-19 lat, a niemal 80% z nich mieszkała w mieście powyżej 500 tys. mieszkańców. Do badania został wykorzystany autorski kwestionariusz w formie papierowej. Zawierał on 21 pytań dotyczących badanego problemu oraz 3 pytania dotyczące wieku, płci oraz miejsca zamieszkania badanych osób. Uzyskane wyniki poddano analizie statystycznej z wykorzystaniem testu Chi2 Pearsona. Za istotne statystycznie różnice uznano te, dla których prawdopodobieństwo p<0.05. Wyniki Zdecydowana większość licealistów bierze kąpiel - codziennie 60% badanych. Żaden ankietowany licealista nie kąpie się dwa razy w tygodniu. Ponad połowa 55% ankietowanych odpowiedziała, że myje włosy codziennie. Żaden z ankietowanych nie odpowiedział że w ogóle nie myje włosów. Na pytanie jak często ankietowani myją zęby, ponad połowa 54% odpowiedziała, że myje zęby dwa razy dziennie. Wnioski Zachowania higieniczne licealistów s

Trudności w wykonywaniu pracy na stanowisku pielęgniarki pediatrycznej = Difficulties in performing work at the workplace of a paediatric nurse

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Kinga Dorota Kulczycka

2016-10-01

  Katedra i Zakład Zarządzania w Pielęgniarstwie Wydział Nauk o Zdrowiu Uniwersytet Medyczny w Lublinie Katedra Pielęgniarstwa Collegium Mazovia Innowacyjna Szkoła Wyższa Siedlce   Chair and Department of Management in Nursing Faculty Health Sciences Medical University of Lublin Department of Nursing Collegium Mazovia Innovative School Siedlce     dr n.med. Kinga Kulczycka, mgr Monika Grenda, dr n.med. Ewa Stychno     Słowa kluczowe: obciążenie pracą, narażenie zawodowe, pielęgniarki Key words: work load, occupational exposure, nurses Streszczenie Badaniem relacji zachodzących między pracownikiem, stanowiskiem i środowiskiem pracy zajmuje się ergonomia. Nauka ta zainteresowana jest głównie poszukiwaniem jak najlepszych rozwiązań pozwalających na optymalizację procesu pracy oraz dostosowanie ich do właściwości biologicznych człowieka. Zagrożenia zdrowia w pracy pielęgniarki pediatrycznej stanowią poważny problem, zarówno medyczny jak i społeczny. Czynniki stanowiące trudności w wykonywaniu pracy zawodowej prowadzą często do nadmiernego obciążenia. Celem pracy jest wskazanie czynników wywołujących obciążenie fizyczne u pielęgniarek pracujących na oddziałach pediatrycznych. Materiał i metody : Badania przeprowadzono w grupie 110 pielęgniarek zatrudnionych na trzech oddziałach pediatrycznych od lutego do kwietnia 2015 roku. Narzędziem badawczym był  zmodyfikowany kwestionariusz do badania obciążenia  IMDS oraz ilościowy pomiar obciążenia QWI. Opracowanie STATISTICA PL 10, i EXCELL. P<=0,05. Część badawcza. Przyjmowane niefizjologiczne pozycje oraz czynności wykonywane w skręcie, pozycji kucznej i z obciążeniem kończyn górnych stanowią podstawowe trudności. Pielęgniarki postrzegają zbyt małą przestrzeń pracy, oraz skrępowanie ciała podczas realizacji zadań nad pacjentami. Wnioski:  Planowanie zadań ich przydzielanie powinno uwzględniać odpowiednie tempo i obciążenie pracą oraz

General Information

International Nuclear Information System (INIS)

Wieteska, K.

2002-01-01

The Institute of Atomic Energy (IAE) emerged in 1983 as one of three research institutes formed on the basis of the Institute of Nuclear Research. Originally the main task for the IAE was research in the field of the reactor physics and techniques needed for nuclear power plant operation and maintenance. Since nineties the priorities were broadened. At present they cover the basic and applied research aiming at the development of both pro ecological energy systems and applications of new nuclear technologies in medicine and industry including nuclear and non-nuclear energy sources.The main research facility of the IAE is the MARIA reactor of 30 MW (thermal). In 2001 the reactor was used mainly for production of radioisotopes for medicine and for neutron scattering studies. The decommissioning of the old reactor EWA was finished and the final reports were prepared. In 2001 the reactor MARIA completed 36 operational cycles with operation time of 3598 hours. No abnormal situations occurred. In the frame of implementation of medium enriched fuel in MARIA reactor, at the end of 2001 only two 80% enriched fuel assembly were used in reactor core. The full conversion was expected at the beginning of 2002. The analysis of the physical parameters for operating purposes of the reactor and the exploitation of spent fuel storage facilities were performed. Based on the results from the WIW-300 installation, the flow resistance in primary fuel cooling circuit in the case of boiling was evaluated. To prevent the corrosion damage of MR spent fuel stored in technological pool of MARIA reactor, the encapsulation technology was adapted. The ecology, economy and safety of nuclear facilities were considered, taking into account the possibility of construction of a nuclear power plant in Poland. The experiments of interaction of fast neutrons from spallation source with U/Pb pile in JINR (Dubna) were performed. The Institute has also started the design and construction of a facility for

Editorial

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Zoran Velagić

2015-06-01

digital age explore how the emergence of subscription models influences the development of new publishing products which bring together the author and the publisher in a joint effort to reach a larger number of readers; and Ivana Hebrang Grgić (Publishing Croatian scientific journals: to e- or not to e-? discusses the extent to which Croatian journal publishers adapted to the electronic environment. In section three, dedicated to the teaching of publishing at the university level, Aušra Navickienė (Third Level Publishing Studies: Lithuania, a Case Study, Ewa Jabłońska-Stefanowicz (Three R’s in publishing education, and Josipa Selthofer (What comes first? Publishing business or publishing studies? provide examples of publishing studies programmes in Lithuania (focusing on the Institute of Book Science and Documentation of Vilnius University, Poland (focusing on the LIS Institute of the University of Wroclaw and Croatia, in comparison with relevant programmes in Europe and the United States. Finally, section four presents three papers which petition for the status of publishing studies as an emerging scientific discipline. Sophie Noël in Publishing studies: the search for an elusive academic object questions the validity of publishing studies as an academic discipline, while trying to situate them within the field of social sciences. She argues that a more appropriate frame could be adopted to describe what people studying the transformations of book publishing do – or should do – both at a theoretical and methodological levels. Christoph Bläsi (Publishing studies: being part of a cultural practice plus x? relates the question of an advanced self-conception of publishing studies to the question what criteria have to be fulfilled to call a field (such as publishing studies a scholarly discipline. He presents the first results of an ongoing project in which he conducts extensive expert interviews with representatives of UK Publishing Studies study programmes and

6th International Symposium on Molecular Allergology (ISMA

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Christiane Hilger

2016-10-01

Mills, Adrian Rogers, Aage Otherhals P65 Fish and peanut allergens interact with plasma membranes of intestinal and bronchial epithelial cells and induce differential gene expression of cytokines and chemokines Tanja Kalic, Isabella Ellinger, Chiara Palladino, Barbara Gepp, Eva Waltl, Verena Niederberger-Leppin, Heimo Breiteneder P66 Interleukin 4 affects fat tissue metabolism and expression of pro-inflammatory factors in isolated rat adipocytes Dawid Szczepankiewicz, Ewa Pruszynska-Oszmalek, Marek Skrzypski, Krzysztof W. Nowak, Aleksandra Szczepankiewicz P67 Ozone induced airway hyperreactivity in PD-L2−/− mice model Gwang-Cheon Jang P68 Thymic stromal lymphopoietin (TSLP and its receptor as targets for the development of anti-inflammatory inhibitory agents Iva Markovic, Andreas Borowski, Tina Vetter, Andreas Wohlmann, Michael Kuepper, Karlheinz Friedrich P69 The mononuclear phagocyte system in experimentally-induced allergic rhinitis Ibon Eguiluz Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Anya C Jones, Maria Lexberg, Patrick G Holt, Espen Sønderaal Bækkevold, Frode Lars Jahnsen P70 Expression of histamine metabolizing enzymes is increased in allergic children Aleksandra Szczepankiewicz, Paulina Sobkowiak, Marta Rachel, Beata Narozna, Dorota Jenerowicz, Witold Swiatowy, Anna Breborowicz P71 Modifying the glycosylation of human IgE towards oligomannosidic structures does not affect its biological activity Melanie Plum, Sara Wolf, Frank Bantleon, Henning Seismann, Frederic Jabs, Michaela Miehe, Thilo Jakob, Edzard Spillner P72 Flying Labs: an educational initiative to transfer allergy research into high-school settings Michael Wallner, Heidi Hofer, Fatima Ferreira, Reinhard Nestelbacher P73 Clinical significance of antihistamines and Kujin, an anti-allergic Kampo medicine Hiroyuki Fukui