WorldWideScience

Sample records for evolving starburst modeling

  1. Marshal: Maintaining Evolving Models Project

    Data.gov (United States)

    National Aeronautics and Space Administration — SIFT proposes to design and develop the Marshal system, a mixed-initiative tool for maintaining task models over the course of evolving missions. Marshal-enabled...

  2. Power-law Temperature Distribution SED Modeling To Reveal Properties of High-z Starburst Galaxies

    Science.gov (United States)

    Su, Ting; Staguhn, J.; Dwek, E.; Kovacs, A.

    2014-01-01

    Sub-millimeter galaxies (SMGs), selected as the most luminous sources in submm/mm surveys in recent decades, are a group of highly dust-obscured massive galaxies at high redshifts energized by starbursts. SMG surveys enable us to study the nature of those sources in detail. Previous samples of SMGs are typically distributed at z ˜ 0.5-3. In order to explore the evolutionary properties of SMGs up to an earlier epoch, we present a sample of 12 sources at average z ˜ 4. Five of our sources are from the GISMO 2mm Deep Field survey-the very first 2mm deep field survey, which favors higher redshift sources with its superior sensitivity and relatively longer wavelength. The other seven are extremely high redshift SMGs (z > 4) including six from Michalowski et al. 2010b and one at z=5.3 from Dwek et al. 2011. Since rest frame far-infrared continuum dust emission is the best tracer of star-formation activities to date, we employ a power-law temperature distribution SED model to analyze the data. This model which fits for dust grains embedded in a radiation field, allows for different dust compositions, size distribution, and emission region geometry. Our fit results represent the data very accurately even in the Wien part of the SED. Our analysis shows that the SED is not optically thin around the SED peak, as is often assumed. In my talk I will present source fitting results of dust mass, dust temperature, index of temperature power-law distribution, and emission region size. Furthermore, I will analyze the evolutionary trends of SMGs properties with redshift and discuss astrophysical implications for those results.

  3. Evidence of ongoing AGN-driven feedback in a quiescent post-starburst E+A galaxy

    Science.gov (United States)

    Baron, Dalya; Netzer, Hagai; Poznanski, Dovi; Prochaska, Jason Xavier; Förster Schreiber, Natascha M.

    2017-09-01

    Post-starburst E+A galaxies are thought to have experienced a significant starburst that was quenched abruptly. Their disturbed, bulge-dominated morphologies suggest that they are merger remnants. We present Echelle Spectrograph and Imager/Keck observations of SDSS J132401.63+454620.6, a post-starburst galaxy at redshift z = 0.125, with a starburst that started 400 Myr ago, and other properties, like the star formation rate consistent with what is measured in ultraluminous infrared galaxies (ULRIGs). The galaxy shows both zero velocity narrow lines, and blueshifted broader Balmer and forbidden emission lines (FWHM = 1350 ± 240 km s-1). The narrow component is consistent with LINER-like emission, and the broader component with Seyfert-like emission, both photoionized by an active galactic nucleus (AGN) whose properties we measure and model. The velocity dispersion of the broad component exceeds the escape velocity, and we estimate the mass outflow rate to be in the range 4-120 M⊙ yr-1. This is the first reported case of AGN-driven outflows, traced by ionized gas, in post-starburst E+A galaxies. We show, by ways of a simple model, that the observed AGN-driven winds can consistently evolve a ULIRG into the observed galaxy. Our findings reinforce the evolutionary scenario where the more massive ULIRGs are quenched by negative AGN feedback, evolve first to post-starburst galaxies, and later become typical red and dead ellipticals.

  4. The spectral energy distribution of powerful starburst galaxies - I. Modelling the radio continuum

    Science.gov (United States)

    Galvin, T. J.; Seymour, N.; Marvil, J.; Filipović, M. D.; Tothill, N. F. H.; McDermid, R. M.; Hurley-Walker, N.; Hancock, P. J.; Callingham, J. R.; Cook, R. H.; Norris, R. P.; Bell, M. E.; Dwarakanath, K. S.; For, B.; Gaensler, B. M.; Hindson, L.; Johnston-Hollitt, M.; Kapińska, A. D.; Lenc, E.; McKinley, B.; Morgan, J.; Offringa, A. R.; Procopio, P.; Staveley-Smith, L.; Wayth, R. B.; Wu, C.; Zheng, Q.

    2018-02-01

    We have acquired radio-continuum data between 70 MHz and 48 GHz for a sample of 19 southern starburst galaxies at moderate redshifts (0.067 attributed to free-free absorption across multiple regions of star formation with varying optical depths. The decomposed synchrotron and free-free emission components in our sample of galaxies form strong correlations with the total-infrared bolometric luminosities. Finally, we find that without accounting for free-free absorption with turnovers between 90 and 500 MHz the radio continuum at low frequency (ν value of -0.8 for normal galaxies. We suggest this may be caused by an intrinsically steeper cosmic ray distribution.

  5. From starburst to quiescence: testing active galactic nucleus feedback in rapidly quenching post-starburst galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Yesuf, Hassen M.; Faber, S. M.; Trump, Jonathan R.; Koo, David C.; Fang, Jerome J.; Liu, F. S. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Wild, Vivienne [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, KY16 9SS (United Kingdom); Hayward, Christopher C. [Heidelberger Institut für Theoretische Studien, Schloss-Wolfsbrunnenweg 35, D-69118 Heidelberg (Germany)

    2014-09-10

    Post-starbursts are galaxies in transition from the blue cloud to the red sequence. Although they are rare today, integrated over time they may be an important pathway to the red sequence. This work uses Sloan Digital Sky Survey, the Galaxy Evolution Explorer, and Wide-field Infrared Survey Explorer observations to identify the evolutionary sequence from starbursts to fully quenched post-starbursts (QPSBs) in the narrow mass range log M(M {sub ☉}) = 10.3-10.7, and identifies 'transiting' post-starbursts (TPSBs) which are intermediate between these two populations. In this mass range, ∼0.3% of galaxies are starbursts, ∼0.1% are QPSBs, and ∼0.5% are the transiting types in between. The TPSBs have stellar properties that are predicted for fast-quenching starbursts and morphological characteristics that are already typical of early-type galaxies. The active galactic nucleus (AGN) fraction, as estimated from optical line ratios, of these post-starbursts is about three times higher (≳ 36% ± 8%) than that of normal star forming galaxies of the same mass, but there is a significant delay between the starburst phase and the peak of nuclear optical AGN activity (median age difference of ≳ 200 ± 100 Myr), in agreement with previous studies. The time delay is inferred by comparing the broadband near-NUV-to-optical photometry with stellar population synthesis models. We also find that starbursts and post-starbursts are significantly more dust obscured than normal star forming galaxies in the same mass range. About 20% of the starbursts and 15% of the TPSBs can be classified as 'dust-obscured galaxies' (DOGs), with a near-UV-to-mid-IR flux ratio of ≳ 900, while only 0.8% of normal galaxies are DOGs. The time delay between the starburst phase and AGN activity suggests that AGNs do not play a primary role in the original quenching of starbursts but may be responsible for quenching later low-level star formation by removing gas and dust during

  6. Modelling the Pan-Spectral Energy Distribution of Starburst Galaxies: III. Emission Line Diagnostics of Ensembles of H II Regions

    Energy Technology Data Exchange (ETDEWEB)

    Dopita, M A; Fischera, J; Sutherland, R S; Kewley, L J; Leitherer, C; Tuffs, R J; Popescu, C C; van Breugel, W; Groves, B A

    2006-05-10

    We have built, as far as possible, fully self-consistent models of H II regions around aging clusters of stars. These produce strong emission line diagnostics applicable to either individual H II regions in galaxies, or to the integrated emission line spectra of disk or starburst galaxies. The models assume that the expansion and internal pressure of individual H II regions is driven by the net input of mechanical energy from the central cluster, be it through winds or supernova events. This eliminates the ionization parameter as a free variable, replacing it with a parameter which depends on the ratio of the cluster mass to the pressure in the surrounding interstellar medium. These models explain why H II regions with low abundances have high excitation, and demonstrate that at least part of the warm ionized medium is the result of overlapping faint, old, large, and low pressure H II regions. We present a number of line ratios (at both optical and IR wavelengths) that provide reliable abundance diagnostics for either single H II regions or for integrated galaxy spectra, and others that are sensitive to the age of the cluster stars exciting individual H II regions.

  7. A local-world evolving hypernetwork model

    Science.gov (United States)

    Yang, Guang-Yong; Liu, Jian-Guo

    2014-01-01

    Complex hypernetworks are ubiquitous in the real system. It is very important to investigate the evolution mechanisms. In this paper, we present a local-world evolving hypernetwork model by taking into account the hyperedge growth and local-world hyperedge preferential attachment mechanisms. At each time step, a newly added hyperedge encircles a new coming node and a number of nodes from a randomly selected local world. The number of the selected nodes from the local world obeys the uniform distribution and its mean value is m. The analytical and simulation results show that the hyperdegree approximately obeys the power-law form and the exponent of hyperdegree distribution is γ = 2 + 1/m. Furthermore, we numerically investigate the node degree, hyperedge degree, clustering coefficient, as well as the average distance, and find that the hypernetwork model shares the scale-free and small-world properties, which shed some light for deeply understanding the evolution mechanism of the real systems.

  8. An evolving model of online bipartite networks

    Science.gov (United States)

    Zhang, Chu-Xu; Zhang, Zi-Ke; Liu, Chuang

    2013-12-01

    Understanding the structure and evolution of online bipartite networks is a significant task since they play a crucial role in various e-commerce services nowadays. Recently, various attempts have been tried to propose different models, resulting in either power-law or exponential degree distributions. However, many empirical results show that the user degree distribution actually follows a shifted power-law distribution, the so-called Mandelbrot’s law, which cannot be fully described by previous models. In this paper, we propose an evolving model, considering two different user behaviors: random and preferential attachment. Extensive empirical results on two real bipartite networks, Delicious and CiteULike, show that the theoretical model can well characterize the structure of real networks for both user and object degree distributions. In addition, we introduce a structural parameter p, to demonstrate that the hybrid user behavior leads to the shifted power-law degree distribution, and the region of power-law tail will increase with the increment of p. The proposed model might shed some lights in understanding the underlying laws governing the structure of real online bipartite networks.

  9. EVOLVE

    CERN Document Server

    Deutz, André; Schütze, Oliver; Legrand, Pierrick; Tantar, Emilia; Tantar, Alexandru-Adrian

    2017-01-01

    This book comprises nine selected works on numerical and computational methods for solving multiobjective optimization, game theory, and machine learning problems. It provides extended versions of selected papers from various fields of science such as computer science, mathematics and engineering that were presented at EVOLVE 2013 held in July 2013 at Leiden University in the Netherlands. The internationally peer-reviewed papers include original work on important topics in both theory and applications, such as the role of diversity in optimization, statistical approaches to combinatorial optimization, computational game theory, and cell mapping techniques for numerical landscape exploration. Applications focus on aspects including robustness, handling multiple objectives, and complex search spaces in engineering design and computational biology.

  10. Gamma-ray Spectra of Starburst Galaxies

    Science.gov (United States)

    Moncada, Roberto Jose; Paglione, Timothy

    2018-01-01

    Starburst galaxies offer a unique window into the nature of star formation, its driving forces, and the energetic interactions within the galaxy. Their supernovae enrich the surrounding environment with cosmic rays that interact with the interstellar medium and galactic magnetic fields producing gamma-rays and non-thermal radio emission. We generated gamma-ray spectra for the 7 brightest starburst galaxies using 8.6 years of Pass 8 Large Area Telescope (LAT) data from the Fermi Gamma-ray Space Telescope. In addition to new detections, we will report on the results of simultaneously modeling the gamma-ray and radio spectra. These results confirm prior studies favoring high magnetic field strengths in the starburst regions.

  11. How the social model of disability evolved.

    Science.gov (United States)

    Durell, Shirley

    The way nurses conceptualise disability influences their practice. Many use an individualised model, seeing disability as an individual problem arising from activity restriction and psychological loss. However, many disabled people are critical of this approach and instead promote a social way of thinking about disability. This article presents an overview of the individual and social models of disability so nurses can increase their understanding of these approaches.

  12. Modeling promoter grammars with evolving hidden Markov models

    DEFF Research Database (Denmark)

    Won, Kyoung-Jae; Sandelin, Albin; Marstrand, Troels Torben

    2008-01-01

    factors are involved in the regulation of a set of co-regulated genes. If so, promoters can be modeled with connected regulatory features, where the network of connections is characteristic for a particular mode of regulation. RESULTS: With the goal of automatically deciphering such regulatory structures......MOTIVATION: Describing and modeling biological features of eukaryotic promoters remains an important and challenging problem within computational biology. The promoters of higher eukaryotes in particular display a wide variation in regulatory features, which are difficult to model. Often several......, we present a method that iteratively evolves an ensemble of regulatory grammars using a hidden Markov Model (HMM) architecture composed of interconnected blocks representing transcription factor binding sites (TFBSs) and background regions of promoter sequences. The ensemble approach reduces the risk...

  13. Modeling and Understanding Time-Evolving Scenarios

    Directory of Open Access Journals (Sweden)

    Riccardo Melen

    2015-08-01

    Full Text Available In this paper, we consider the problem of modeling application scenarios characterized by variability over time and involving heterogeneous kinds of knowledge. The evolution of distributed technologies creates new and challenging possibilities of integrating different kinds of problem solving methods, obtaining many benefits from the user point of view. In particular, we propose here a multilayer modeling system and adopt the Knowledge Artifact concept to tie together statistical and Artificial Intelligence rule-based methods to tackle problems in ubiquitous and distributed scenarios.

  14. Conceptualizing Evolving Models of Educational Development

    Science.gov (United States)

    Fraser, Kym; Gosling, David; Sorcinelli, Mary Deane

    2010-01-01

    Educational development, which the authors use to refer to the field of professional and strategic development associated with university and college learning and teaching, can be described in many ways by referring to its different aspects. In this article the authors endeavor to categorize many of the models that have been used to describe…

  15. Evolving the structure of hidden Markov Models

    DEFF Research Database (Denmark)

    won, K. J.; Prugel-Bennett, A.; Krogh, A.

    2006-01-01

    A genetic algorithm (GA) is proposed for finding the structure of hidden Markov Models (HMMs) used for biological sequence analysis. The GA is designed to preserve biologically meaningful building blocks. The search through the space of HMM structures is combined with optimization of the emission...

  16. Modeling and clustering users with evolving profiles in usage streams

    KAUST Repository

    Zhang, Chongsheng

    2012-09-01

    Today, there is an increasing need of data stream mining technology to discover important patterns on the fly. Existing data stream models and algorithms commonly assume that users\\' records or profiles in data streams will not be updated or revised once they arrive. Nevertheless, in various applications such asWeb usage, the records/profiles of the users can evolve along time. This kind of streaming data evolves in two forms, the streaming of tuples or transactions as in the case of traditional data streams, and more importantly, the evolving of user records/profiles inside the streams. Such data streams bring difficulties on modeling and clustering for exploring users\\' behaviors. In this paper, we propose three models to summarize this kind of data streams, which are the batch model, the Evolving Objects (EO) model and the Dynamic Data Stream (DDS) model. Through creating, updating and deleting user profiles, these models summarize the behaviors of each user as a profile object. Based upon these models, clustering algorithms are employed to discover interesting user groups from the profile objects. We have evaluated all the proposed models on a large real-world data set, showing that the DDS model summarizes the data streams with evolving tuples more efficiently and effectively, and provides better basis for clustering users than the other two models. © 2012 IEEE.

  17. Observations of the Hubble Deep Field with the Infrared Space Observatory .5. Spectral energy distributions, starburst models and star formation history

    DEFF Research Database (Denmark)

    Rowan Robinson, M.; Mann, R.G.; Oliver, S.J.

    1997-01-01

    the star formation rate can be deduced from the far-infrared luminosity, and derive star formation rates for these galaxies of 8-1000 phi M. yr(-1), where phi takes account of the uncertainty in the initial mass function, The HDF galaxies detected by ISO are clearly forming stars at, a prodigious rate......We have modelled the spectral energy distributions of the 13 Hubble Deep Field (HDF) galaxies reliably detected by the Infrared Space Observatory (ISO). For two galaxies the emission detected by ISO is consistent with being starlight or the infrared 'cirrus' in the galaxies. For the remaining II...... galaxies there is a clear midinfrared excess, which we interpret as emission from dust associated with a strong starburst. 10 of these galaxies are spirals or interacting pairs, while the remaining one is an elliptical with a prominent nucleus and broad emission lines. We give a new discussion of how...

  18. Exploring, exploiting and evolving diversity of aquatic ecosystem models

    DEFF Research Database (Denmark)

    Janssen, Annette B. G.; Arhonditsis, George B.; Beusen, Arthur

    2015-01-01

    Here, we present a community perspective on how to explore, exploit and evolve the diversity in aquatic ecosystem models. These models play an important role in understanding the functioning of aquatic ecosystems, filling in observation gaps and developing effective strategies for water quality...... management. In this spirit, numerous models have been developed since the 1970s. We set off to explore model diversity by making an inventory among 42 aquatic ecosystem modellers, by categorizing the resulting set of models and by analysing them for diversity. We then focus on how to exploit model diversity...... by comparing and combining different aspects of existing models. Finally, we discuss how model diversity came about in the past and could evolve in the future. Throughout our study, we use analogies from biodiversity research to analyse and interpret model diversity. We recommend to make models publicly...

  19. Exploring, exploiting and evolving diversity of aquatic ecosystem models

    NARCIS (Netherlands)

    Janssen, A.B.G.; Arhonditsis, G.B.; Beusen, Arthur; Bolding, Karsten; Bruce, Louise; Bruggeman, Jorn; Couture, Raoul Marie; Downing, Andrea S.; Alex Elliott, J.; Frassl, M.A.; Gal, Gideon; Gerla, Daan J.; Hipsey, M.R.; Hu, Fenjuan; Ives, S.C.; Janse, J.H.; Jeppesen, Erik; Jöhnk, K.D.; Kneis, David; Kong, Xiangzhen; Kuiper, J.J.; Lehmann, M.K.; Lemmen, Carsten; Özkundakci, Deniz; Petzoldt, Thomas; Rinke, Karsten; Robson, B.J.; Sachse, René; Schep, S.A.; Schmid, Martin; Scholten, Huub; Teurlincx, Sven; Trolle, Dennis; Troost, T.A.; Dam, Van A.A.; Gerven, Van L.P.A.; Weijerman, Mariska; Wells, S.A.; Mooij, W.M.

    2015-01-01

    Here, we present a community perspective on how to explore, exploit and evolve the diversity in aquatic ecosystem models. These models play an important role in understanding the functioning of aquatic ecosystems, filling in observation gaps and developing effective strategies for water quality

  20. What is Enhancing the Tidal Disruption Rate of Stars in Post-Starburst Galaxies?

    Science.gov (United States)

    Arcavi, Iair

    2016-10-01

    The search for the tidal disruption of stars by supermassive black holes (tidal disruption events; TDEs) is now yielding exciting results. Recently, we tied several events together into a coherent class of outbursts. This picture offers a surprising new insight: TDEs show a strong (200x) preference for post-starburst galaxies. Why is this? As likely post-merger galaxies, they could harbor a binary black hole in their center, which is expected to increase the rate of TDEs, but only at certain ages after the merger and for certain merger mass ratios. Alternatively, a disturbed central potential or nuclear gas reservoirs may be affecting stellar orbits in the core of the galaxy. Finally, a nuclear over-abundance of A stars (which dominate ground-based galaxy-integrated spectra), evolving to giants, could increase the global cross section for tidal disruption. HST spatial resolution and low surface brightness sensitivity allows us to test each of these options for four post-starburst TDE host galaxies. We will measure post-merger tidal tails, age-date the starburst using individual star cluster colors, map the luminosity profile of the inner 100pc to test for asphericity or double nuclei, and localize the weak line emission and A-star population seen in our galaxy-integrated spectra. We will also perform bulge-disk decompositions to estimate the mass of the central black hole, a crucial test of TDE emission models. Our group has successfully carried out HST analyses of the star cluster populations, tidal tails, and core surface brightness profiles of (non-TDE-host) post-starburst galaxies, a sample which will serve as a control for the observations proposed here.

  1. Modelling the Pan-Spectral Energy Distribution of Starburst Galaxies: II. Control of the H II Region Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Dopita, M A; Fischera, J; Sutherland, R S; Kewley, L J; Tuffs, R J; Popescu, C C; van Breugel, W; Groves, B A; Leitherer, C

    2006-03-01

    We examine from a theoretical viewpoint how the physical parameters of H II regions are controlled both in normal galaxies and in starburst environments. These parameters are the H II region luminosity function, the time-dependent size, the covering fraction of molecular clouds, the pressure in the ionized gas and the ionization parameter. The factors which control them are the initial mass function of the exciting stars, the cluster mass function, the metallicity and the mean pressure in the surrounding interstellar medium. We investigate the sensitivity of the H{alpha} luminosity to the IMF, and find that this can translate to about 30% variation in derived star formation rates. The molecular cloud dissipation timescale is estimated from a case study of M17 to be {approx} 1 Myr. Based upon H II luminosity function fitting for nearby galaxies, we propose that the cluster mass function has a log-normal form peaking at {approx} 185M{sub {circle_dot}}. This suggests that the cluster mass function is the continuation of the stellar IMF to higher mass. The pressure in the H II regions is controlled by the mechanical luminosity flux from the central cluster. Since this is closely related to the ionizing photon flux, we show that the ionization parameter is not a free variable, and that the diffuse ionized medium may be composed of many large, faint and old H II regions. Finally, we derive theoretical probability distributions for the ionization parameter as a function of metallicity and compare these to those derived for SDSS galaxies.

  2. AUTOMOTIVE APPLICATIONS OF EVOLVING TAKAGI-SUGENO-KANG FUZZY MODELS

    Directory of Open Access Journals (Sweden)

    Radu-Emil Precup

    2017-08-01

    Full Text Available This paper presents theoretical and application results concerning the development of evolving Takagi-Sugeno-Kang fuzzy models for two dynamic systems, which will be viewed as controlled processes, in the field of automotive applications. The two dynamic systems models are nonlinear dynamics of the longitudinal slip in the Anti-lock Braking Systems (ABS and the vehicle speed in vehicles with the Continuously Variable Transmission (CVT systems. The evolving Takagi-Sugeno-Kang fuzzy models are obtained as discrete-time fuzzy models by incremental online identification algorithms. The fuzzy models are validated against experimental results in the case of the ABS and the first principles simulation results in the case of the vehicle with the CVT.

  3. Evolution of Compact Extreme Starburst Galaxies

    Science.gov (United States)

    Lowenthal, James; Bershady, Matthew; Gallego, Jesus; Guzman, Rafael; Hameed, Salman; Koo, David

    2006-05-01

    The global SFR was tenfold greater at z=1 than at z=0, and "downsizing" scenarios of galaxy formation maintain that the strong evolution in SFR progresses from high- to low-mass systems with time. Meanwhile, large reservoirs of star formation previously hidden from the optical by obscuring dust are being uncovered in the IR and submm in diverse populations of galaxies over a wide range of redshift. We propose deep IRAC imaging and MIPS photometry of a unique sample of well-studied 26 extreme starburst galaxies, half of them nearby HII galaxies and the other half luminous compact blue galaxies (LCBGs) at redshift z~0.5. These intensely starforming but mostly low-mass systems, like their massive cousins the ultraluminous infrared galaxies (ULIRGs), apparently evolve significantly: they can account for as much as 40% of the increase in global SFR observed between z=0 and z=1. They may also include local analogs of Lyman break galaxies at z~3, and are probably the same class of UV-bright starbursts recently observed in the local universe with GALEX. Coverage of our sample has two significant advantages over other multiwavelength surveys: spatially resolved HST/STIS-UV and optical imaging and spectroscopy, and high spectral and spatial resolution 2D spectroscopy with Keck/HIRES. Thus we can measure important physical parameters that are unavailable with the FLS, EGSS, GOODS, and other surveys. Our main science goal is (1) to use the mid- and far-IR emission to measure optically obscured star formation from z~1 to z=0 as a function of dynamical mass and rest-UV size and morphology; this will directly address inconsistencies in our current downsizing picture of galaxy evolution and the role of compact extreme starbursts. We also plan (2) to compare the SEDs of our samples to those of LBGs, to test the hypothesis that LCBGs include local analogs of LBGs; and (3) to measure the starbursts' stellar masses in the rest-NIR, which is necessary for analysis of SFH, b parameter

  4. Reducing starbursts in highly aberrated eyes with pupil miosis.

    Science.gov (United States)

    Xu, Renfeng; Kollbaum, Pete; Thibos, Larry; Lopez-Gil, Norberto; Bradley, Arthur

    2018-01-01

    To test the hypothesis that marginal ray deviations determine perceived starburst sizes, and to explore different strategies for decreasing starburst size in highly aberrated eyes. Perceived size of starburst images and visual acuities were measured psychophysically for eyes with varying levels of spherical aberration, pupil sizes, and defocus. Computationally, we use a polychromatic eye model including the typical levels of higher order aberrations (HOAs) for keratoconic and post-LASIK eyes to quantify the image quality (the visually weighted Strehl ratio derived from the optical transfer function, VSOTF) with different pupil sizes at both photopic and mesopic light levels. For distance corrected post-LASIK and keratoconic eyes with a night-time pupil (e.g., 7 mm), the starburst diameter is about 1.5 degrees (1 degree for normal presbyopic eyes), which can be reduced to ≤0.25 degrees with pupil sizes ≤3 mm. Starburst size is predicted from the magnitude of the longitudinal spherical aberration. Refracting the eye to focus the pupil margin also removed starbursts, but, unlike small pupils, significantly degraded visual acuity. Reducing pupil diameter to 3 mm improved image quality for these highly aberrated eyes by about 2.7 ×  to 1.7 ×  relative to the natural pupils when light levels were varied from 0.1 to 1000 cd m-2 , respectively. Subjects with highly aberrated eyes observed larger starbursts around bright lights at night predictable by the deviated marginal rays. These were effectively attenuated by reducing pupil diameters to ≤3 mm, which did not cause a drop in visual acuity or modelled image quality even at mesopic light levels. © 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists.

  5. Evolvable mathematical models: A new artificial Intelligence paradigm

    Science.gov (United States)

    Grouchy, Paul

    We develop a novel Artificial Intelligence paradigm to generate autonomously artificial agents as mathematical models of behaviour. Agent/environment inputs are mapped to agent outputs via equation trees which are evolved in a manner similar to Symbolic Regression in Genetic Programming. Equations are comprised of only the four basic mathematical operators, addition, subtraction, multiplication and division, as well as input and output variables and constants. From these operations, equations can be constructed that approximate any analytic function. These Evolvable Mathematical Models (EMMs) are tested and compared to their Artificial Neural Network (ANN) counterparts on two benchmarking tasks: the double-pole balancing without velocity information benchmark and the challenging discrete Double-T Maze experiments with homing. The results from these experiments show that EMMs are capable of solving tasks typically solved by ANNs, and that they have the ability to produce agents that demonstrate learning behaviours. To further explore the capabilities of EMMs, as well as to investigate the evolutionary origins of communication, we develop NoiseWorld, an Artificial Life simulation in which interagent communication emerges and evolves from initially noncommunicating EMM-based agents. Agents develop the capability to transmit their x and y position information over a one-dimensional channel via a complex, dialogue-based communication scheme. These evolved communication schemes are analyzed and their evolutionary trajectories examined, yielding significant insight into the emergence and subsequent evolution of cooperative communication. Evolved agents from NoiseWorld are successfully transferred onto physical robots, demonstrating the transferability of EMM-based AIs from simulation into physical reality.

  6. Duplication Detection When Evolving Feature Models of Software Product Lines

    Directory of Open Access Journals (Sweden)

    Amal Khtira

    2015-10-01

    Full Text Available After the derivation of specific applications from a software product line, the applications keep evolving with respect to new customer’s requirements. In general, evolutions in most industrial projects are expressed using natural language, because it is the easiest and the most flexible way for customers to express their needs. However, the use of this means of communication has shown its limits in detecting defects, such as inconsistency and duplication, when evolving the existing models of the software product line. The aim of this paper is to transform the natural language specifications of new evolutions into a more formal representation using natural language processing. Then, an algorithm is proposed to automatically detect duplication between these specifications and the existing product line feature models. In order to instantiate the proposed solution, a tool is developed to automatize the two operations.

  7. A weighted network evolving model with capacity constraints

    Science.gov (United States)

    Wu, XiaoHuan; Zhu, JinFu; Wu, WeiWei; Ge, Wei

    2013-09-01

    Most of existing works on complex network assumed that the nodes and edges were uncapacitated during the evolving process, and displayed "rich club" phenomenon. Here we will show that the "rich club" could be changed to "common rich" if we consider the node capacity. In this paper, we define the node and edge attractive index with node capacity, and propose a new evolving model on the base of BBV model, with evolving simulations of the networks. In the new model, an entering node is linked with an existing node according to the preferential attachment mechanism defined with the attractive index of the existing node. We give the theoretical approximation and simulation solutions. If node capacity is finite, the rich node may not be richer further when the node strength approaches or gets to the node capacity. This is confirmed by analyzing the passenger traffic and routes of Chinese main airports. Due to node strength being function of time t, we can use the theoretical approximation solution to forecast how node strength changes and the time when node strength reaches its maximum value.

  8. Evolving Four Part Harmony Using a Multiple Worlds Model

    DEFF Research Database (Denmark)

    Scirea, Marco; Brown, Joseph Alexander

    2015-01-01

    This application of the Multiple Worlds Model examines a collaborative fitness model for generating four part harmonies. In this model we have multiple populations and the fitness of the individuals is based on the ability of a member from each population to work with the members of other...... populations. We present the result of two experiments: the generation of compositions, given a static voice line, both in a constrained and unconstrained harmonic framework. The remaining three voices are evolved using this collaborative fitness function, which looks for a number of classical composition...

  9. Modeling the Chinese language as an evolving network

    Science.gov (United States)

    Liang, Wei; Shi, Yuming; Huang, Qiuling

    2014-01-01

    The evolution of Chinese language has three main features: the total number of characters is gradually increasing, new words are generated in the existing characters, and some old words are no longer used in daily-life language. Based on the features, we propose an evolving language network model. Finally, we use this model to simulate the character co-occurrence networks (nodes are characters, and two characters are connected by an edge if they are adjacent to each other) constructed from essays in 11 different periods of China, and find that characters that appear with high frequency in old words are likely to be reused when new words are formed.

  10. Modelling cell motility and chemotaxis with evolving surface finite elements.

    Science.gov (United States)

    Elliott, Charles M; Stinner, Björn; Venkataraman, Chandrasekhar

    2012-11-07

    We present a mathematical and a computational framework for the modelling of cell motility. The cell membrane is represented by an evolving surface, with the movement of the cell determined by the interaction of various forces that act normal to the surface. We consider external forces such as those that may arise owing to inhomogeneities in the medium and a pressure that constrains the enclosed volume, as well as internal forces that arise from the reaction of the cells' surface to stretching and bending. We also consider a protrusive force associated with a reaction-diffusion system (RDS) posed on the cell membrane, with cell polarization modelled by this surface RDS. The computational method is based on an evolving surface finite-element method. The general method can account for the large deformations that arise in cell motility and allows the simulation of cell migration in three dimensions. We illustrate applications of the proposed modelling framework and numerical method by reporting on numerical simulations of a model for eukaryotic chemotaxis and a model for the persistent movement of keratocytes in two and three space dimensions. Movies of the simulated cells can be obtained from http://homepages.warwick.ac.uk/∼maskae/CV_Warwick/Chemotaxis.html.

  11. HerMES: The rest-frame UV emission and a lensing model for the z = 6.34 luminous dusty starburst galaxy HFLS3

    Energy Technology Data Exchange (ETDEWEB)

    Cooray, Asantha; Calanog, Jae; Casey, C. M.; Ma, Brian; Osage, W. A. [Center for Cosmology, Department of Physics and Astronomy, University of California, Irvine, CA 92697 (United States); Wardlow, Julie L. [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Bock, J.; Bridge, C. [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Burgarella, D. [Laboratoire d' Astrophysique de Marseille, Aix-Marseille University, CNRS, F-13013 Marseille (France); Bussmann, R. S. [Department of Astronomy, Space Science Building, Cornell University, Ithaca, NY 14853-6801 (United States); Clements, D. [Astrophysics Group, Imperial College London, Blackett Laboratory, Prince Consort Road, London SW7 2AZ (United Kingdom); Conley, A. [Department of Astrophysical and Planetary Sciences, CASA 389-UCB, University of Colorado, Boulder, CO 80309 (United States); Farrah, D. [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States); Fu, H. [Department of Physics and Astronomy, University of Iowa, Iowa City, IA 52242 (United States); Gavazzi, R. [Institut d' Astrophysique de Paris, UMR 7095, CNRS, UPMC Univ. Paris 06, 98bis boulevard Arago, F-75014 Paris (France); Ivison, R. J. [European Southern Observatory, Karl Schwarzschild Strasse 2, D-85748 Garching (Germany); La Porte, N. [Pontificia Universidad Caólica de Chile, Departamento de Astronomía y Astrofísica, Casilla 306, Santiago 22 (Chile); Lo Faro, B. [Aix-Marseille Université, CNRS, LAM (Laboratoire d' Astrophysique de Marseille) UMR7326, F-13388 Marseille (France); Magdis, G. [Department of Astrophysics, Denys Wilkinson Building, University of Oxford, Keble Road, Oxford OX1 3RH (United Kingdom); Oliver, S. J. [Astronomy Centre, Department of Physics and Astronomy, University of Sussex, Brighton BN1 9QH (United Kingdom); and others

    2014-07-20

    We discuss the rest-frame ultraviolet emission from the starbursting galaxy HFLS3 at a redshift of 6.34. The galaxy was discovered in Herschel/SPIRE data due to its red color in the submillimeter wavelengths from 250 to 500 μm. Keck/NIRC2 K{sub s}-band adaptive optics imaging data showed two potential near-IR counterparts near HFLS3. Previously, the northern galaxy was taken to be in the foreground at z = 2.1, while the southern galaxy was assumed to be HFLS3's near-IR counterpart. The recently acquired Hubble/WFC3 and Advanced Camera for Surveys (ACS) imaging data show conclusively that both optically bright galaxies are in the foreground at z < 6. A new lensing model based on the Hubble imaging data and the millimeter-wave continuum emission yields a magnification factor of 2.2 ± 0.3, with a 95% confidence upper limit on the magnification of 3.5. When corrected for lensing, the instantaneous star formation rate is 1320 M{sub ☉} yr{sup –1}, with the 95% confidence lower limit around 830 M{sub ☉} yr{sup –1}. The dust and stellar masses of HFLS3 from the same spectral energy distribution (SED) models are at the level of 3 × 10{sup 8} M{sub ☉} and ∼5 × 10{sup 10} M{sub ☉}, respectively, with large systematic uncertainties on assumptions related to the SED model. With Hubble/WFC3 images, we also find diffuse near-IR emission about 0.5 arcsec (∼3 kpc) to the southwest of HFLS3 that remains undetected in the ACS imaging data. The emission has a photometric redshift consistent with either z ∼ 6 or a dusty galaxy template at z ∼ 2.

  12. The starburst ring around the Seyfert nucleus in NGC 7469

    Science.gov (United States)

    Wilson, A. S.; Helfer, T. T.; Haniff, C. A.; Ward, M. J.

    1991-01-01

    High-resolution radio continuum, optical emission line, and optical continuum images of the luminous Seyfert plus circumnuclear starburst hybrid galaxy NGC 7469 are presented. The radio emission from the starburst is largely confined to a ring of diameter 3 arcsec, or 1.0 kpc. There is clear evidence for optical continuum emission and probably optical line emission from the ring. The disks of NGC 1068 and NGC 7469 exhibit a strong similarity in almost all observed properties. Current star formation models can account for the luminous far-infrared emission and the strength of the nonthermal radio emission in NGC 7469, with an expected supernova rate of about one per year. The starburst ring is probably a result of concentration of gas into a ring via resonances between orbital motion and a rotating barlike or ovally distorted potential.

  13. Evolving the Topology of Hidden Markov Models using Evolutionary Algorithms

    DEFF Research Database (Denmark)

    Thomsen, Réne

    2002-01-01

    Hidden Markov models (HMM) are widely used for speech recognition and have recently gained a lot of attention in the bioinformatics community, because of their ability to capture the information buried in biological sequences. Usually, heuristic algorithms such as Baum-Welch are used to estimate...... the model parameters. However, Baum-Welch has a tendency to stagnate on local optima. Furthermore, designing an optimal HMM topology usually requires a priori knowledge from a field expert and is usually found by trial-and-error. In this study, we present an evolutionary algorithm capable of evolving both...... the topology and the model parameters of HMMs. The applicability of the method is exemplified on a secondary structure prediction problem....

  14. Beyond expressive writing: evolving models of developmental creative writing.

    Science.gov (United States)

    Nicholls, Sophie

    2009-03-01

    Pennebaker's expressive writing paradigm has helped to introduce the benefits of writing to health care. However, research in expressive writing has been largely dominated by an experimental and quantitative approach that does not take into account critical methodologies and approaches in health psychology, the increasingly complex ways in which creative writing is now being used in health care settings or recent research in the broader field of creative writing and personal development, health and well-being (developmental creative writing). This article contrasts expressive writing theories and methodologies with those evolving in the relatively new field of developmental creative writing. It investigates a number of theoretical and methodological problems with the expressive writing model and argues for a more critical approach to future research.

  15. A Markovian model of evolving world input-output network.

    Science.gov (United States)

    Moosavi, Vahid; Isacchini, Giulio

    2017-01-01

    The initial theoretical connections between Leontief input-output models and Markov chains were established back in 1950s. However, considering the wide variety of mathematical properties of Markov chains, so far there has not been a full investigation of evolving world economic networks with Markov chain formalism. In this work, using the recently available world input-output database, we investigated the evolution of the world economic network from 1995 to 2011 through analysis of a time series of finite Markov chains. We assessed different aspects of this evolving system via different known properties of the Markov chains such as mixing time, Kemeny constant, steady state probabilities and perturbation analysis of the transition matrices. First, we showed how the time series of mixing times and Kemeny constants could be used as an aggregate index of globalization. Next, we focused on the steady state probabilities as a measure of structural power of the economies that are comparable to GDP shares of economies as the traditional index of economies welfare. Further, we introduced two measures of systemic risk, called systemic influence and systemic fragility, where the former is the ratio of number of influenced nodes to the total number of nodes, caused by a shock in the activity of a node, and the latter is based on the number of times a specific economic node is affected by a shock in the activity of any of the other nodes. Finally, focusing on Kemeny constant as a global indicator of monetary flow across the network, we showed that there is a paradoxical effect of a change in activity levels of economic nodes on the overall flow of the world economic network. While the economic slowdown of the majority of nodes with high structural power results to a slower average monetary flow over the network, there are some nodes, where their slowdowns improve the overall quality of the network in terms of connectivity and the average flow of the money.

  16. Highlights And Shadows Of High Redshift Starbursts: A Herschel­Fmos Joint Effort

    Science.gov (United States)

    Puglisi, Annagrazia

    2017-06-01

    Starburst galaxies represent a critical stage in galaxy evolution as they are the likely progenitors of passively evolving ellipticals. The properties of high-redshift starbursts are however still debated as it is not clear to which extent their vigorous star formation rate is caused by an enhanced gas fraction or an enhanced star formation efficiency, and what physical processes trigger such violent activity. Our study of the rest-frame optical spectra from the FMOS-COSMOS survey of twelve z 1.6 Herschel starbursts combined with a rich ancillary data-set from UV to ALMA, is shedding light on some of these questions. By measuring the nebular extinction from different indicators, we find that 90% of their extreme SFR arises from an heavily obscured component which is thick in the optical. We also measure their gas-phase metallicity, showing that starbursts are metal-rich outliers from the metallicity-SFR anticorrelation observed at fixed stellar mass for the main sequence population. Our findings are consistent with a major merger origin for the starburst event. I will present this study discussing its implications on our interpretation of the high-redshift starbursts physics. I will also briefly discuss possible extensions of this work with the future PFS survey and how we can take advantage of the IFU capabilities of JWST/NIRspec to unveil the complex structure of these elusive systems.

  17. Starbursts From 30 Doradus to Lyman Break Galaxies

    CERN Document Server

    Grijs, Richard

    2005-01-01

    Starbursts are important features of early galaxy evolution. Many of the distant, high-redshift galaxies we are able to detect are in a starbursting phase, often apparently provoked by a violent gravitational interaction with another galaxy. In fact, if we did not know that major starbursts existed, these conference proceedings testify that we would indeed have difficulties explaining the key properties of the Universe! These conference proceedings cover starbursts from the small-scale star-forming regions in nearby galaxies to galaxy-wide events at high redshifts; one of the major themes of the conference proved to be "scalability", i.e., can we scale up the small-scale events to describe the physics on larger scales. The key outcome of this meeting – and these proceedings – is a resounding "yes" as answer to this fundamental, yet profound question. The enhanced synergy facilitated by the collaboration among observers using cutting-edge ground and space-based facilities, theorists and modellers has made ...

  18. Molecular outflows in starburst nuclei

    Science.gov (United States)

    Roy, Arpita; Nath, Biman B.; Sharma, Prateek; Shchekinov, Yuri

    2016-12-01

    Recent observations have detected molecular outflows in a few nearby starburst nuclei. We discuss the physical processes at work in such an environment in order to outline a scenario that can explain the observed parameters of the phenomenon, such as the molecular mass, speed and size of the outflows. We show that outflows triggered by OB associations, with NOB ≥ 105 (corresponding to a star formation rate (SFR)≥1 M⊙ yr-1 in the nuclear region), in a stratified disc with mid-plane density n0 ˜ 200-1000 cm-3 and scaleheight z0 ≥ 200(n0/102 cm-3)-3/5 pc, can form molecules in a cool dense and expanding shell. The associated molecular mass is ≥107 M⊙ at a distance of a few hundred pc, with a speed of several tens of km s-1. We show that an SFR surface density of 10 ≤ ΣSFR ≤ 50 M⊙ yr-1 kpc-2 favours the production of molecular outflows, consistent with observed values.

  19. Beyond the nuclear starburst? Clustered star formation in major mergers

    Science.gov (United States)

    Powell, Leila C.; Bournaud, Frederic; Chapon, Damien; Teyssier, Romain

    2013-09-01

    Recent simulation work has successfully captured the formation of the star clusters that have been observed in merging galaxies. These studies, however, tend to focus on studying extreme starbursts, such as the Antennae galaxies. We aim to establish whether there is something special occurring in these extreme systems or whether the mechanism for cluster formation is present in all mergers to a greater or lesser degree. We undertake a general study of merger-induced star formation in a sample of 5 pc resolution adaptive mesh refinement simulations of low-redshift equal-mass mergers with randomly chosen orbital parameters. We find that there is an enhanced mass fraction of very dense gas that appears as the gas density probability density function evolves during the merger. This finding has implications for the interpretation of some observations; a larger mass fraction of dense gas could account for the enhanced HCN/CO ratios seen in ultraluminous infrared galaxies and predict that αCO is lower in mergers, as for a given mass of H2, CO emission will increase in a denser environment. We also find that as the star formation rate increases, there is a correlated peak in the velocity dispersion of the gas, which we attribute to increasing turbulence driven by the interaction itself. Star formation tends to be clumpy: in some cases there is extended clumpy star formation, but even when star formation is concentrated within the inner kpc (i.e. what may be considered a nuclear starburst) it still often has a clumpy, rather than a smooth, distribution. We find no strong evidence for a clear bimodality in the Kennicutt-Schmidt relation for the average mergers simulated here. Instead, they are typically somewhat offset above the predicted quiescent relation during their starbursts.

  20. Genetic programming for evolving due-date assignment models in job shop environments.

    Science.gov (United States)

    Nguyen, Su; Zhang, Mengjie; Johnston, Mark; Tan, Kay Chen

    2014-01-01

    Due-date assignment plays an important role in scheduling systems and strongly influences the delivery performance of job shops. Because of the stochastic and dynamic nature of job shops, the development of general due-date assignment models (DDAMs) is complicated. In this study, two genetic programming (GP) methods are proposed to evolve DDAMs for job shop environments. The experimental results show that the evolved DDAMs can make more accurate estimates than other existing dynamic DDAMs with promising reusability. In addition, the evolved operation-based DDAMs show better performance than the evolved DDAMs employing aggregate information of jobs and machines.

  1. [Evolvement of ecological footprint model representing ecological carrying capacity].

    Science.gov (United States)

    Cao, Shu-yan; Xie, Gao-di

    2007-06-01

    Ecological footprint (EF) is an important index of ecological carrying capacity. The original EF model is excellent in simplicity, aggregation, comparability, and lifelikeness in presenting results, but short in predictability, configuration, and applicability. To overcome these shortcomings, many researches were conducted to modify and promote the EF model, and developed it from static with single time scale to diversified ones, which included: 1) time series EF model, 2) input-output analysis based EF model, 3) integrated assessment incorporated EF model, 4) land disturbance degree based EF model, and 5) life cycle analysis based EF model, or component EF model. The function of EF as a measurement of ecological carrying capacity was significantly improved, but its accuracy and integrality still need to be advanced.

  2. Bayesian Mixed-Membership Models of Complex and Evolving Networks

    Science.gov (United States)

    2006-12-01

    are based on the stochastic block model (SBM) formalism for psychometric and sociological analysis pioneered 71 3.1. ADMIXTURE OF LATENT BLOCKS MODEL... Biotechnology , 23:1562–1567, 2005. T. Van Zandt. Decentralized information processing in the theory of organizations. In M. Ser- tel, editor, Contemporary

  3. Model for the Evolving Bed Surface around an Offshore Monopile

    DEFF Research Database (Denmark)

    Hartvig, Peres Akrawi

    2012-01-01

    This paper presents a model for the bed surface around an offshore monopile. The model has been designed from measured laboratory bed surfaces and is shown to reproduce these satisfactorily for both scouring and backfilling. The local rate of the bed elevation is assumed to satisfy a certain gene...

  4. An Evolving Asymmetric Game for Modeling Interdictor-Smuggler Problems

    Science.gov (United States)

    2016-06-01

    3–30. Morton D, Pan F, Saeger K (2007) Models for nuclear smuggling interdiction. IIE Transactions . 39(1): 3–14. Nehme M (2009) Two-person games...Twister: a 623-dimensionally equidistributed uniform pseudo-random number generator. ACM Transactions on Modeling and Computer Simulation (TOMACS) 8(1

  5. An exceptionally bright, compact starburst nucleus

    Science.gov (United States)

    Margon, Bruce; Anderson, Scott F.; Mateo, Mario; Fich, Michel; Massey, Philip

    1988-01-01

    Observations are reported of a remarkably bright (V about 13) starburst nucleus, 0833 + 652, which has been detected at radio, infrared, optical, ultraviolet, and X-ray wavelengths. Despite an observed flux at each of these wavelengths which is comparable to that of NGC 7714, often considered the 'prototypical' example of the starburst phenomenon, 0833 + 652 appears to be a previously uncataloged object. Its ease of detectability throughout the electromagnetic spectrum should make it useful for a variety of problems in the study of compact emission-line galaxies.

  6. Local starburst galaxies and their descendants. Statistics from the Sloan Digital Sky Survey

    Science.gov (United States)

    Bergvall, Nils; Marquart, Thomas; Way, Michael J.; Blomqvist, Anna; Holst, Emma; Ostlin, Goran; Zackrisson, Erik

    2016-01-01

    Despite strong interest in the starburst phenomenon in extragalactic astronomy, the concept remains ill-defined. Here we use a strict definition of starburst to examine the statistical properties of starburst galaxies in the local universe. We also seek to establish links between starburst galaxies, post-starburst (hereafter postburst) galaxies, and active galaxies. Data were selected from the Sloan Digital Sky Survey DR7. We applied a novel method of treating dust attenuation and derive star formation rates, ages, and stellar masses assuming a two-component stellar population model. Dynamical masses are calculated from the width of the H-alpha line. These masses agree excellently with the photometric masses. The mass (gas+stars) range is approximately 10( exp 9) - 10(exp 11.5) solar mass. As a selection criterion for starburst galaxies, we use, the birthrate parameter, b = SFR/SFR, requiring that b is greater than 3. For postburst galaxies, we use, the equivalent width of Hdelta in absorption with the criterion EW (sub Hdelta_abs) is greater than 6 A. Results. We find that only 1% of star-forming galaxies are starburst galaxies. They contribute 3-6% to the stellar production and are therefore unimportant for the local star formation activity. The median starburst age is 70 Myr roughly independent of mass, indicating that star formation is mainly regulated by local feedback processes. The b-parameter strongly depends on burst age. Values close to b = 60 are found at ages approximately 10 Myr, while almost no starbursts are found at ages greater than 1 Gyr. The median baryonic burst mass fraction of sub-L galaxies is 5% and decreases slowly towards high masses. The median mass fraction of the recent burst in the postburst sample is 5-10%. A smaller fraction of the postburst galaxies, however, originates in non-bursting galaxies. The age-mass distribution of the postburst progenitors (with mass fractions is greater than 3%) is bimodal with a break at logM(solar mass

  7. Our evolving conceptual model of the coastal eutrophication problem

    Science.gov (United States)

    Cloern, James E.

    2001-01-01

    A primary focus of coastal science during the past 3 decades has been the question: How does anthropogenic nutrient enrichment cause change in the structure or function of nearshore coastal ecosystems? This theme of environmental science is recent, so our conceptual model of the coastal eutrophication problem continues to change rapidly. In this review, I suggest that the early (Phase I) conceptual model was strongly influenced by limnologists, who began intense study of lake eutrophication by the 1960s. The Phase I model emphasized changing nutrient input as a signal, and responses to that signal as increased phytoplankton biomass and primary production, decomposition of phytoplankton-derived organic matter, and enhanced depletion of oxygen from bottom waters. Coastal research in recent decades has identified key differences in the responses of lakes and coastal-estuarine ecosystems to nutrient enrichment. The contemporary (Phase II) conceptual model reflects those differences and includes explicit recognition of (1) system-specific attributes that act as a filter to modulate the responses to enrichment (leading to large differences among estuarine-coastal systems in their sensitivity to nutrient enrichment); and (2) a complex suite of direct and indirect responses including linked changes in: water transparency, distribution of vascular plants and biomass of macroalgae, sediment biogeochemistry and nutrient cycling, nutrient ratios and their regulation of phytoplankton community composition, frequency of toxic/harmful algal blooms, habitat quality for metazoans, reproduction/growth/survival of pelagic and benthic invertebrates, and subtle changes such as shifts in the seasonality of ecosystem functions. Each aspect of the Phase II model is illustrated here with examples from coastal ecosystems around the world. In the last section of this review I present one vision of the next (Phase III) stage in the evolution of our conceptual model, organized around 5

  8. Low-complexity stochastic modeling of spatially evolving flows

    Science.gov (United States)

    Zare, Armin; Ran, Wei; Hack, M. J. Philipp; Jovanovic, Mihailo

    2016-11-01

    Low-complexity approximations of the Navier-Stokes (NS) equations are commonly used for analysis and control of turbulent flows. In particular, stochastically-forced linearized models have been successfully employed to capture structural and statistical features observed in experiments and direct simulations. In this work, we utilize stochastically-forced linearized NS equations and their parabolized equivalents to study the dynamics of flow fluctuations in transitional and turbulent boundary layers. We exploit the streamwise causality of the parabolized model to efficiently propagate statistics of stochastic disturbances into statistics of velocity fluctuations. Our study provides insight into interactions of slowly-varying base flow with streamwise streaks, oblique modes, and Tollmien-Schlichting waves. It also offers a systematic, computationally efficient framework for quantifying the influence of stochastic excitation sources (e.g., free-stream turbulence and surface roughness) on velocity fluctuations in weakly non-parallel flows.

  9. An Evolving Model for Capacity Building with Earth Observation Imagery

    Science.gov (United States)

    Sylak-Glassman, E. J.

    2015-12-01

    For the first forty years of Earth observation satellite imagery, all imagery was collected by civilian or military governmental satellites. Over this timeframe, countries without observation satellite capabilities had very limited access to Earth observation data or imagery. In response to the limited access to Earth observation systems, capacity building efforts were focused on satellite manufacturing. Wood and Weigel (2012) describe the evolution of satellite programs in developing countries with a technology ladder. A country moves up the ladder as they move from producing satellites with training services to building satellites locally. While the ladder model may be appropriate if the goal is to develop autonomous satellite manufacturing capability, in the realm of Earth observation, the goal is generally to derive societal benefit from the use of Earth observation-derived information. In this case, the model for developing Earth observation capacity is more appropriately described by a hub-and-spoke model in which the use of Earth observation imagery is the "hub," and the "spokes" describe the various paths to achieving that imagery: the building of a satellite (either independently or with assistance), the purchase of a satellite, participation in a constellation of satellites, and the use of freely available or purchased satellite imagery. We discuss the different capacity-building activities that are conducted in each of these pathways, such as the "Know-How Transfer and Training" program developed by Surrey Satellite Technology Ltd. , Earth observation imagery training courses run by SERVIR in developing countries, and the use of national or regional remote sensing centers (such as those in Morocco, Malaysia, and Kenya) to disseminate imagery and training. In addition, we explore the factors that determine through which "spoke" a country arrives at the ability to use Earth observation imagery, and discuss best practices for achieving the capability to use

  10. Clinical coaching: Evolving the apprenticeship model for modern housestaff.

    Science.gov (United States)

    Rangachari, Deepa; Brown, Lorrel E; Kern, David E; Melia, Michael T

    2017-07-01

    Feedback is one of the core components of teaching in the clinical setting. Traditionally, this activity has emphasized observations made by senior physicians and delivered to medical trainees. However, the optimal approach to feedback remains uncertain, and the literature abounds with trainee-perceived inadequacies in feedback content, quality, and impact. Moreover, given the multiplicity of demands on trainees and their physician mentors, we propose that medical trainees themselves-specifically, medical residents-are poised to serve as unique adjunct effectors of feedback. We propose a model of "clinical coaching" for residents as teachers, with emphasis on the active roles of both the feedback "giver" and "recipient". We define "clinical coaching" as "a helping longitudinal relationship between coach and apprentice that provides continuing feedback on and assistance with improving performance." Here, "coach" is the more experienced trainee (e.g. supervising resident), and "apprentice" is the less experienced trainee (e.g. intern or medical student). By working to better recognize and prepare residents for this vital role, we propose to encourage efforts to optimize the structure, execution, and impact of feedback in the contemporary climate of medical education.

  11. Empirical Models of Social Learning in a Large, Evolving Network.

    Directory of Open Access Journals (Sweden)

    Ayşe Başar Bener

    Full Text Available This paper advances theories of social learning through an empirical examination of how social networks change over time. Social networks are important for learning because they constrain individuals' access to information about the behaviors and cognitions of other people. Using data on a large social network of mobile device users over a one-month time period, we test three hypotheses: 1 attraction homophily causes individuals to form ties on the basis of attribute similarity, 2 aversion homophily causes individuals to delete existing ties on the basis of attribute dissimilarity, and 3 social influence causes individuals to adopt the attributes of others they share direct ties with. Statistical models offer varied degrees of support for all three hypotheses and show that these mechanisms are more complex than assumed in prior work. Although homophily is normally thought of as a process of attraction, people also avoid relationships with others who are different. These mechanisms have distinct effects on network structure. While social influence does help explain behavior, people tend to follow global trends more than they follow their friends.

  12. A quantum Bose-Hubbard model with evolving graph as toy model for emergent spacetime

    CERN Document Server

    Hamma, Alioscia; Lloyd, Seth; Caravelli, Francesco; Severini, Simone; Markstrom, Klas

    2009-01-01

    We present a toy model for interacting matter and geometry that explores quantum dynamics in a spin system as a precursor to a quantum theory of gravity. The model has no a priori geometric properties, instead, locality is inferred from the more fundamental notion of interaction between the matter degrees of freedom. The interaction terms are themselves quantum degrees of freedom so that the structure of interactions and hence the resulting local and causal structures are dynamical. The system is a Hubbard model where the graph of the interactions is a set of quantum evolving variables. We show entanglement between spatial and matter degrees of freedom. We study numerically the quantum system and analyze its entanglement dynamics. We analyze the asymptotic behavior of the classical model. Finally, we discuss analogues of trapped surfaces and gravitational attraction in this simple model.

  13. Analysing an Evolved Robotic Behaviour Using a Biological Model of Collegial Decision Making.

    OpenAIRE

    Francesca, Gianpiero; Brambilla, Manuele; Trianni, Vito; Dorigo, Marco; BIRATTARI, Mauro

    2012-01-01

    Evolutionary robotics can be a powerful tool in studies on the evolutionary origins of self-organising behaviours in biological systems. However, these studies are viable only when the behaviour of the evolved artificial system closely corresponds to the one observed in biology, as described by available models. In this paper, we compare the behaviour evolved in a robotic system with the collegial decision making displayed by cockroaches in selecting a resting shelter. We show that artificial...

  14. High energy (gamma)-ray emission from the starburst nucleus of NGC 253

    Energy Technology Data Exchange (ETDEWEB)

    Domingo-Santamaria, E; Torres, D F

    2005-06-15

    The high density medium that characterizes the central regions of starburst galaxies and its power to accelerate particles up to relativistic energies make these objects good candidates as {gamma}-rays sources. In this paper, a self-consistent model of the multifrequency emission of the starburst galaxy NGC 253, from radio to gamma-rays, is presented. The model is in agreement with all current measurements and provides predictions for the high energy behavior of the NGC 253 central region. Prospects for observations with the HESS array and GLAST satellite are especially discussed.

  15. An evolving experience learned for modelling thermal dynamics of buildings from live experiments: the Flexhouse story

    DEFF Research Database (Denmark)

    Yu, Xingji; You, Shi; Jiang, Yuewen

    2017-01-01

    Abstract This paper shares an evolving experience learned for modelling the thermal dynamics of buildings from live experiments run in Flexhouse1 at Risø Campus of Technical University of Denmark (DTU). Among different trials, circuit based grey-box models approach have been developed and improved...... from time to time. Although the intension of modelling the thermal dynamics of Flexhouse1 remains unchanged, the details of experiments and applied modelling approach do evolve over time due to the increase of knowledge and the improvement made to the experimental platform. In addition to presenting...

  16. Introducing an Evolving Local Neuro-Fuzzy Model--Application to modeling of car-following behavior.

    Science.gov (United States)

    Kazemi, Reza; Abdollahzade, Majid

    2015-11-01

    This paper proposes an Evolving Local Linear Neuro-Fuzzy Model for modeling and identification of nonlinear time-variant systems which change their nature and character over time. The proposed approach evolves through time to follow the structural changes in the time-variant dynamic systems. The evolution process is managed by a distance-based extended hierarchical binary tree algorithm, which decides whether the proposed evolving model should be adapted to the system variations or evolution is necessary. To represent an interesting but challenging example of the systems with changing dynamics, the proposed evolving model is applied to model car-following process in a traffic flow, as an online identification problem. Results of simulations demonstrate effectiveness of the proposed approach in modeling of the time-variant systems. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  17. Environmental noise, genetic diversity and the evolution of evolvability and robustness in model gene networks.

    Directory of Open Access Journals (Sweden)

    Christopher F Steiner

    Full Text Available The ability of organisms to adapt and persist in the face of environmental change is accepted as a fundamental feature of natural systems. More contentious is whether the capacity of organisms to adapt (or "evolvability" can itself evolve and the mechanisms underlying such responses. Using model gene networks, I provide evidence that evolvability emerges more readily when populations experience positively autocorrelated environmental noise (red noise compared to populations in stable or randomly varying (white noise environments. Evolvability was correlated with increasing genetic robustness to effects on network viability and decreasing robustness to effects on phenotypic expression; populations whose networks displayed greater viability robustness and lower phenotypic robustness produced more additive genetic variation and adapted more rapidly in novel environments. Patterns of selection for robustness varied antagonistically with epistatic effects of mutations on viability and phenotypic expression, suggesting that trade-offs between these properties may constrain their evolutionary responses. Evolution of evolvability and robustness was stronger in sexual populations compared to asexual populations indicating that enhanced genetic variation under fluctuating selection combined with recombination load is a primary driver of the emergence of evolvability. These results provide insight into the mechanisms potentially underlying rapid adaptation as well as the environmental conditions that drive the evolution of genetic interactions.

  18. Catalytic Oxygen Evolution by a Bioinorganic Model of the Photosystem II Oxygen-Evolving Complex

    Science.gov (United States)

    Howard, Derrick L.; Tinoco, Arthur D.; Brudvig, Gary W.; Vrettos, John S.; Allen, Bertha Connie

    2005-01-01

    Bioinorganic models of the manganese Mn4 cluster are important not only as aids in understanding the structure and function of the oxygen-evolving complex (OEC), but also in developing artificial water-oxidation catalysts. The mechanism of water oxidation by photosystem II (PSII) is thought to involve the formation of a high-valent terminal Mn-oxo…

  19. Evolvement law of a macroscopic traffic model accounting for density-dependent relaxation time

    Science.gov (United States)

    Wang, Yu-Qing; Chu, Xing-Jian; Zhou, Chao-Fan; Jia, Bin; Lin, Sen; Wu, Zi-Han; Zhu, Hua-Bing; Gao, Zi-You

    2017-11-01

    In this paper, a modified macroscopic traffic flow model is presented. The term of the density-dependent relaxation time is introduced here. The relation between the relaxation time and the density in traffic flow is presented quantitatively. Besides, a factor R depicting varied properties of traffic flow in different traffic states is also introduced in the formulation of the model. Furthermore, the evolvement law of traffic flow with distinctly initial density distribution and boundary perturbations is emphasized.

  20. E+A Galaxy Properties and Post-Starburst Galaxy Evolution Data through SDSS-IV MaNGA and Illustris: A Co-Analysis

    Science.gov (United States)

    Ojanen, Winonah; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Johnson, Amalya; Kerrison, Nicole; Marinelli, Mariarosa; Melchert, Nancy; Liu, Charles; Sloan Collaboration, SDSS-IV MaNGA

    2018-01-01

    E+A galaxies (Elliptical + A-type stars) are post-starburst galaxies that have experienced a sudden quenching phase. Using previous research methods, 39 candidates out of 2,812 galaxies observed, or 1.4%, were selected from the SDSS-IV MaNGA survey. We then identified morphological characteristics of the 39 galaxies including stellar kinematics, Gini coefficient, gas density and distribution and stellar ages. To study the origin of how E+A galaxies evolved to their present state, galaxy simulation data from the Illustris simulation was utilized to identify similar quenched post-starburst candidates. Seven post-starburst candidates were identified through star formation rate histories of Illustris simulated galaxies. The evolution of these galaxies is studied from 0 to 13.8 billion years ago to identify what caused the starburst and quenching of the Illustris candidates. Similar morphological characteristics of Illustris post-starburst candidates are pulled from before, during, and post-starburst and compared to the same morphological characteristics of the E+A galaxies from SDSS-IV MaNGA. The characteristics and properties of the Illustris galaxies are used to identify the possible evolutionary histories of the observed E+A galaxies. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  1. PyEvolve: a toolkit for statistical modelling of molecular evolution.

    Science.gov (United States)

    Butterfield, Andrew; Vedagiri, Vivek; Lang, Edward; Lawrence, Cath; Wakefield, Matthew J; Isaev, Alexander; Huttley, Gavin A

    2004-01-05

    Examining the distribution of variation has proven an extremely profitable technique in the effort to identify sequences of biological significance. Most approaches in the field, however, evaluate only the conserved portions of sequences - ignoring the biological significance of sequence differences. A suite of sophisticated likelihood based statistical models from the field of molecular evolution provides the basis for extracting the information from the full distribution of sequence variation. The number of different problems to which phylogeny-based maximum likelihood calculations can be applied is extensive. Available software packages that can perform likelihood calculations suffer from a lack of flexibility and scalability, or employ error-prone approaches to model parameterisation. Here we describe the implementation of PyEvolve, a toolkit for the application of existing, and development of new, statistical methods for molecular evolution. We present the object architecture and design schema of PyEvolve, which includes an adaptable multi-level parallelisation schema. The approach for defining new methods is illustrated by implementing a novel dinucleotide model of substitution that includes a parameter for mutation of methylated CpG's, which required 8 lines of standard Python code to define. Benchmarking was performed using either a dinucleotide or codon substitution model applied to an alignment of BRCA1 sequences from 20 mammals, or a 10 species subset. Up to five-fold parallel performance gains over serial were recorded. Compared to leading alternative software, PyEvolve exhibited significantly better real world performance for parameter rich models with a large data set, reducing the time required for optimisation from approximately 10 days to approximately 6 hours. PyEvolve provides flexible functionality that can be used either for statistical modelling of molecular evolution, or the development of new methods in the field. The toolkit can be used

  2. PyEvolve: a toolkit for statistical modelling of molecular evolution

    Directory of Open Access Journals (Sweden)

    Wakefield Matthew J

    2004-01-01

    Full Text Available Abstract Background Examining the distribution of variation has proven an extremely profitable technique in the effort to identify sequences of biological significance. Most approaches in the field, however, evaluate only the conserved portions of sequences – ignoring the biological significance of sequence differences. A suite of sophisticated likelihood based statistical models from the field of molecular evolution provides the basis for extracting the information from the full distribution of sequence variation. The number of different problems to which phylogeny-based maximum likelihood calculations can be applied is extensive. Available software packages that can perform likelihood calculations suffer from a lack of flexibility and scalability, or employ error-prone approaches to model parameterisation. Results Here we describe the implementation of PyEvolve, a toolkit for the application of existing, and development of new, statistical methods for molecular evolution. We present the object architecture and design schema of PyEvolve, which includes an adaptable multi-level parallelisation schema. The approach for defining new methods is illustrated by implementing a novel dinucleotide model of substitution that includes a parameter for mutation of methylated CpG's, which required 8 lines of standard Python code to define. Benchmarking was performed using either a dinucleotide or codon substitution model applied to an alignment of BRCA1 sequences from 20 mammals, or a 10 species subset. Up to five-fold parallel performance gains over serial were recorded. Compared to leading alternative software, PyEvolve exhibited significantly better real world performance for parameter rich models with a large data set, reducing the time required for optimisation from ~10 days to ~6 hours. Conclusion PyEvolve provides flexible functionality that can be used either for statistical modelling of molecular evolution, or the development of new methods in the

  3. An optical-near-IR study of a triplet of super star clusters in the starburst core of M82

    Energy Technology Data Exchange (ETDEWEB)

    Westmoquette, M. S. [European Southern Observatory, Karl-Schwarzschild-Str. 2, D-85748 Garching bei München (Germany); Bastian, N. [Excellence Cluster Universe, Boltzmannstrasse 2, D-85748 Garching bei München (Germany); Smith, L. J. [Space Telescope Science Institute and European Space Agency, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Seth, A. C. [University of Utah, Salt Lake City, UT 84112 (United States); Gallagher III, J. S.; Ryon, J. E. [Department of Astronomy, University of Wisconsin-Madison, 5534 Sterling, 475 North Charter Street, Madison, WI 53706 (United States); O' Connell, R. W. [Department of Astronomy, University of Virginia, P.O. Box 3818, Charlottesville, VA 22903 (United States); Silich, S.; Mayya, Y. D.; González, D. Rosa [Instituto Nacional de Astrofísica, Optica y Electronica, Luis Enrique Erro 1, Tonantzintla, C.P. 72840, Puebla (Mexico); Muñoz-Tuñón, C., E-mail: westmoquette@gmail.com [Instituto de Astrofísica de Canarias, C/vía Láctea s/n, E-38200 La Laguna, Tenerife (Spain)

    2014-07-10

    We present HST/STIS optical and Gemini/NIFS near-IR IFU spectroscopy and archival Hubble Space Telescope (HST) imaging of the triplet of super star clusters (A1, A2, and A3) in the core of the M82 starburst. Using model fits to the Space Telescope Imaging Spectrograph (STIS) spectra and the weakness of red supergiant CO absorption features (appearing at ∼6 Myr) in the NIFS H-band spectra, the ages of A2 and A3 are 4.5 ± 1.0 Myr. A1 has strong CO bands, consistent with our previously determined age of 6.4 ± 0.5 Myr. The photometric masses of the three clusters are 4-7 × 10{sup 5} M{sub ☉}, and their sizes are R{sub eff} = 159, 104, 59 mas (∼2.8, 1.8, 1.0 pc) for A1, A2, and A3. The STIS spectra yielded radial velocities of 320 ± 2, 330 ± 6, and 336 ± 5 km s{sup –1} for A1, A2, and A3, placing them at the eastern end of the x{sub 2} orbits of M82's bar. Clusters A2 and A3 are in high-density (800-1000 cm{sup –3}) environments, and like A1, are surrounded by compact H II regions. We suggest the winds from A2 and A3 have stalled, as in A1, due to the high ISM ambient pressure. We propose that the three clusters were formed in situ on the outer x{sub 2} orbits in regions of dense molecular gas subsequently ionized by the rapidly evolving starburst. The similar radial velocities of the three clusters and their small projected separation of ∼25 pc suggest that they may merge in the near future unless this is prevented by velocity shearing.

  4. Analytical solution of reaction-diffusion equations for calcium wave propagation in a starburst amacrine cell.

    Science.gov (United States)

    Poznanski, R R

    2010-09-01

    A reaction-diffusion model is presented to encapsulate calcium-induced calcium release (CICR) as a potential mechanism for somatofugal bias of dendritic calcium movement in starburst amacrine cells. Calcium dynamics involves a simple calcium extrusion (pump) and a buffering mechanism of calcium binding proteins homogeneously distributed over the plasma membrane of the endoplasmic reticulum within starburst amacrine cells. The system of reaction-diffusion equations in the excess buffer (or low calcium concentration) approximation are reformulated as a nonlinear Volterra integral equation which is solved analytically via a regular perturbation series expansion in response to calcium feedback from a continuously and uniformly distributed calcium sources. Calculation of luminal calcium diffusion in the absence of buffering enables a wave to travel at distances of 120 μm from the soma to distal tips of a starburst amacrine cell dendrite in 100 msec, yet in the presence of discretely distributed calcium-binding proteins it is unknown whether the propagating calcium wave-front in the somatofugal direction is further impeded by endogenous buffers. If so, this would indicate CICR to be an unlikely mechanism of retinal direction selectivity in starburst amacrine cells.

  5. Spatio-Temporal Data Model for Integrating Evolving Nation-Level Datasets

    Science.gov (United States)

    Sorokine, A.; Stewart, R. N.

    2017-10-01

    Ability to easily combine the data from diverse sources in a single analytical workflow is one of the greatest promises of the Big Data technologies. However, such integration is often challenging as datasets originate from different vendors, governments, and research communities that results in multiple incompatibilities including data representations, formats, and semantics. Semantics differences are hardest to handle: different communities often use different attribute definitions and associate the records with different sets of evolving geographic entities. Analysis of global socioeconomic variables across multiple datasets over prolonged time is often complicated by the difference in how boundaries and histories of countries or other geographic entities are represented. Here we propose an event-based data model for depicting and tracking histories of evolving geographic units (countries, provinces, etc.) and their representations in disparate data. The model addresses the semantic challenge of preserving identity of geographic entities over time by defining criteria for the entity existence, a set of events that may affect its existence, and rules for mapping between different representations (datasets). Proposed model is used for maintaining an evolving compound database of global socioeconomic and environmental data harvested from multiple sources. Practical implementation of our model is demonstrated using PostgreSQL object-relational database with the use of temporal, geospatial, and NoSQL database extensions.

  6. SPATIO-TEMPORAL DATA MODEL FOR INTEGRATING EVOLVING NATION-LEVEL DATASETS

    Directory of Open Access Journals (Sweden)

    A. Sorokine

    2017-10-01

    Full Text Available Ability to easily combine the data from diverse sources in a single analytical workflow is one of the greatest promises of the Big Data technologies. However, such integration is often challenging as datasets originate from different vendors, governments, and research communities that results in multiple incompatibilities including data representations, formats, and semantics. Semantics differences are hardest to handle: different communities often use different attribute definitions and associate the records with different sets of evolving geographic entities. Analysis of global socioeconomic variables across multiple datasets over prolonged time is often complicated by the difference in how boundaries and histories of countries or other geographic entities are represented. Here we propose an event-based data model for depicting and tracking histories of evolving geographic units (countries, provinces, etc. and their representations in disparate data. The model addresses the semantic challenge of preserving identity of geographic entities over time by defining criteria for the entity existence, a set of events that may affect its existence, and rules for mapping between different representations (datasets. Proposed model is used for maintaining an evolving compound database of global socioeconomic and environmental data harvested from multiple sources. Practical implementation of our model is demonstrated using PostgreSQL object-relational database with the use of temporal, geospatial, and NoSQL database extensions.

  7. A JWST Study of the Starburst-AGN Connection in Merging LIRGs

    Science.gov (United States)

    Armus, Lee; Appleton, P.; Barcos-Munoz, L.; Charmandaris, V.; Diaz-Santos, T.; Evans, A.; Howell, J.; Inami, H.; Larson, K.; Linden, S.; Malkan, M.; Marshall, J.; Mazzarella, J.; Medling, A.; Murphy, E.; Privon, G.; Rich, J.; Sanders, D.; Stierwalt, S.; Surace, J.

    2017-11-01

    Galaxies evolve through a combination of secular processes, such as cold gas accretion, and nonsecular processes, such as galactic mergers, which can trigger massive starbursts and powerful AGN. JWST will transform our understanding of galactic evolution, providing a detailed look at the physics of star formation and black hole growth in nearby and distant galaxies. By using NIRSPEC, NIRCAM and MIRI, we will create a rich dataset for understanding the dynamics and energetics of the ISM on scales of 50-100pc in the nuclei of local Luminous Infrared Galaxies (LIRGs). Our targets cover a range of starburst-to-AGN power and IR spectral properties, and are all visible to JWST over the first 5 months of Cycle-1. We will target each nucleus with the NIRSPEC and MIRI IFUs to cover the full spectral range from 0.96-29 microns, and obtain deep, wide-field NIRCAM and MIRI images in the F150W, F200W, F335M, F444W, F560W, F770W and F1500W filters. The total time for our proposal (NOI #80) is 30.97hrs. Our science-enabling products include multi-wavelength, ancillary datasets from Spitzer, ALMA, JVLA, AKARI and HST, valuable cross-calibration infrared data from Spitzer and AKARI, together with custom spectral fitting software which we will deliver and use to analyze the JWST spectral cubes. The proposed observations will be scientifically compelling in their own right, and they will also demonstrate to the community how to fully explore the power of JWST to unravel the complex galactic ecosystems in nearby active and starburst galaxies. This proposal will set the stage for more extensive studies of active and starburst galaxies at low and high-redshift in Cycle-2 and beyond.

  8. Blueberry Galaxies: The Lowest Mass Young Starbursts

    Science.gov (United States)

    Yang, Huan; Malhotra, Sangeeta; Rhoads, James E.; Wang, Junxian

    2017-09-01

    Searching for extreme emission line galaxies allows us to find low-mass metal-poor galaxies that are good analogs of high redshift Lyα emitting galaxies. These low-mass extreme emission line galaxies are also potential Lyman-continuum leakers. Finding them at very low redshifts (z≲ 0.05) allows us to be sensitive to even lower stellar masses and metallicities. We report on a sample of extreme emission line galaxies at z≲ 0.05 (blueberry galaxies). We selected them from SDSS broadband images on the basis of their broadband colors and studied their properties with MMT spectroscopy. From the entire SDSS DR12 photometric catalog, we found 51 photometric candidates. We spectroscopically confirm 40 as blueberry galaxies. (An additional seven candidates are contaminants, and four remain without spectra.) These blueberries are dwarf starburst galaxies with very small sizes (<1 kpc) and very high ionization ([O III]/[O II] ˜ 10-60). They also have some of the lowest stellar masses ({log}(M/{M}⊙ )˜ 6.5{--}7.5) and lowest metallicities (7.1< 12+{log}({{O}}/{{H}})< 7.8) of starburst galaxies. Thus, they are small counterparts to green pea galaxies and high redshift Lyα emitting galaxies.

  9. The Galactic Centre - a laboratory for starburst galaxies (?)

    Science.gov (United States)

    Crocker, Roland M.

    2012-08-01

    The Galactic centre - as the closest galactic nucleus - holds both intrinsic interest and possibly represents a useful analogue to starburst nuclei which we can observe with orders of magnitude finer detail than these external systems. The environmental conditions in the GC - here taken to mean the inner 200 pc in diameter of the Milky Way - are extreme with respect to those typically encountered in the Galactic disk. The energy densities of the various GC ISM components are typically ~two orders of magnitude larger than those found locally and the star-formation rate density ~three orders of magnitude larger. Unusually within the Galaxy, the Galactic centre exhibits hard-spectrum, diffuse TeV (=1012 eV) gamma-ray emission spatially coincident with the region's molecular gas. Recently the nuclei of local starburst galaxies NGC 253 and M82 have also been detected in gamma-rays of such energies. We have embarked on an extended campaign of modelling the broadband (radio continuum to TeV gamma-ray), non- thermal signals received from the inner 200 pc of the Galaxy. On the basis of this modelling we find that star-formation and associated supernova activity is the ultimate driver of the region's non-thermal activity. This activity drives a large-scale wind of hot plasma and cosmic rays out of the GC. The wind advects the locally-accelerated cosmic rays quickly, before they can lose much energy in situ or penetrate into the densest molecular gas cores where star-formation occurs. The cosmic rays can, however, heat/ionize the lower density/warm H 2 phase enveloping the cores. On very large scales (~10 kpc) the non-thermal signature of the escaping GC cosmic rays has probably been detected recently as the spectacular `Fermi bubbles' and corresponding `YWMAP haze'.

  10. The life cycle of starbursting circumnuclear gas discs

    Science.gov (United States)

    Schartmann, M.; Mould, J.; Wada, K.; Burkert, A.; Durré, M.; Behrendt, M.; Davies, R. I.; Burtscher, L.

    2018-01-01

    High-resolution observations from the submm to the optical wavelength regime resolve the central few 100 pc region of nearby galaxies in great detail. They reveal a large diversity of features: thick gas and stellar discs, nuclear starbursts, inflows and outflows, central activity, jet interaction, etc. Concentrating on the role circumnuclear discs play in the life cycles of galactic nuclei, we employ 3D adaptive mesh refinement hydrodynamical simulations with the RAMSES code to self-consistently trace the evolution from a quasi-stable gas disc, undergoing gravitational (Toomre) instability, the formation of clumps and stars and the disc's subsequent, partial dispersal via stellar feedback. Our approach builds upon the observational finding that many nearby Seyfert galaxies have undergone intense nuclear starbursts in their recent past and in many nearby sources star formation is concentrated in a handful of clumps on a few 100 pc distant from the galactic centre. We show that such observations can be understood as the result of gravitational instabilities in dense circumnuclear discs. By comparing these simulations to available integral field unit observations of a sample of nearby galactic nuclei, we find consistent gas and stellar masses, kinematics, star formation and outflow properties. Important ingredients in the simulations are the self-consistent treatment of star formation and the dynamical evolution of the stellar distribution as well as the modelling of a delay time distribution for the supernova feedback. The knowledge of the resulting simulated density structure and kinematics on pc scale is vital for understanding inflow and feedback processes towards galactic scales.

  11. Statistical models for brain signals with properties that evolve across trials

    KAUST Repository

    Ombao, Hernando

    2017-12-07

    Most neuroscience cognitive experiments involve repeated presentations of various stimuli across several minutes or a few hours. It has been observed that brain responses, even to the same stimulus, evolve over the course of the experiment. These changes in brain activation and connectivity are believed to be associated with learning and/or habituation. In this paper, we present two general approaches to modeling dynamic brain connectivity using electroencephalograms (EEGs) recorded across replicated trials in an experiment. The first approach is the Markovian regime-switching vector autoregressive model (MS-VAR) which treats EEGs as realizations of an underlying brain process that switches between different states both within a trial and across trials in the entire experiment. The second is the slowly evolutionary locally stationary process (SEv-LSP) which characterizes the observed EEGs as a mixture of oscillatory activities at various frequency bands. The SEv-LSP model captures the dynamic nature of the amplitudes of the band-oscillations and cross-correlations between them. The MS-VAR model is able to capture abrupt changes in the dynamics while the SEv-LSP directly gives interpretable results. Moreover, it is nonparametric and hence does not suffer from model misspecification. For both of these models, time-evolving connectivity metrics in the frequency domain are derived from the model parameters for both functional and effective connectivity. We illustrate these two models for estimating cross-trial connectivity in selective attention using EEG data from an oddball paradigm auditory experiment where the goal is to characterize the evolution of brain responses to target stimuli and to standard tones presented randomly throughout the entire experiment. The results suggest dynamic changes in connectivity patterns over trials with inter-subject variability.

  12. Evolving Non-Dominated Parameter Sets for Computational Models from Multiple Experiments

    Science.gov (United States)

    Lane, Peter C. R.; Gobet, Fernand

    2013-03-01

    Creating robust, reproducible and optimal computational models is a key challenge for theorists in many sciences. Psychology and cognitive science face particular challenges as large amounts of data are collected and many models are not amenable to analytical techniques for calculating parameter sets. Particular problems are to locate the full range of acceptable model parameters for a given dataset, and to confirm the consistency of model parameters across different datasets. Resolving these problems will provide a better understanding of the behaviour of computational models, and so support the development of general and robust models. In this article, we address these problems using evolutionary algorithms to develop parameters for computational models against multiple sets of experimental data; in particular, we propose the `speciated non-dominated sorting genetic algorithm' for evolving models in several theories. We discuss the problem of developing a model of categorisation using twenty-nine sets of data and models drawn from four different theories. We find that the evolutionary algorithms generate high quality models, adapted to provide a good fit to all available data.

  13. Modeling Slump of Ready Mix Concrete Using Genetically Evolved Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Vinay Chandwani

    2014-01-01

    Full Text Available Artificial neural networks (ANNs have been the preferred choice for modeling the complex and nonlinear material behavior where conventional mathematical approaches do not yield the desired accuracy and predictability. Despite their popularity as a universal function approximator and wide range of applications, no specific rules for deciding the architecture of neural networks catering to a specific modeling task have been formulated. The research paper presents a methodology for automated design of neural network architecture, replacing the conventional trial and error technique of finding the optimal neural network. The genetic algorithms (GA stochastic search has been harnessed for evolving the optimum number of hidden layer neurons, transfer function, learning rate, and momentum coefficient for backpropagation ANN. The methodology has been applied for modeling slump of ready mix concrete based on its design mix constituents, namely, cement, fly ash, sand, coarse aggregates, admixture, and water-binder ratio. Six different statistical performance measures have been used for evaluating the performance of the trained neural networks. The study showed that, in comparison to conventional trial and error technique of deciding the neural network architecture and training parameters, the neural network architecture evolved through GA was of reduced complexity and provided better prediction performance.

  14. A Modified Dynamic Evolving Neural-Fuzzy Approach to Modeling Customer Satisfaction for Affective Design

    Directory of Open Access Journals (Sweden)

    C. K. Kwong

    2013-01-01

    Full Text Available Affective design is an important aspect of product development to achieve a competitive edge in the marketplace. A neural-fuzzy network approach has been attempted recently to model customer satisfaction for affective design and it has been proved to be an effective one to deal with the fuzziness and non-linearity of the modeling as well as generate explicit customer satisfaction models. However, such an approach to modeling customer satisfaction has two limitations. First, it is not suitable for the modeling problems which involve a large number of inputs. Second, it cannot adapt to new data sets, given that its structure is fixed once it has been developed. In this paper, a modified dynamic evolving neural-fuzzy approach is proposed to address the above mentioned limitations. A case study on the affective design of mobile phones was conducted to illustrate the effectiveness of the proposed methodology. Validation tests were conducted and the test results indicated that: (1 the conventional Adaptive Neuro-Fuzzy Inference System (ANFIS failed to run due to a large number of inputs; (2 the proposed dynamic neural-fuzzy model outperforms the subtractive clustering-based ANFIS model and fuzzy c-means clustering-based ANFIS model in terms of their modeling accuracy and computational effort.

  15. A modified dynamic evolving neural-fuzzy approach to modeling customer satisfaction for affective design.

    Science.gov (United States)

    Kwong, C K; Fung, K Y; Jiang, Huimin; Chan, K Y; Siu, Kin Wai Michael

    2013-01-01

    Affective design is an important aspect of product development to achieve a competitive edge in the marketplace. A neural-fuzzy network approach has been attempted recently to model customer satisfaction for affective design and it has been proved to be an effective one to deal with the fuzziness and non-linearity of the modeling as well as generate explicit customer satisfaction models. However, such an approach to modeling customer satisfaction has two limitations. First, it is not suitable for the modeling problems which involve a large number of inputs. Second, it cannot adapt to new data sets, given that its structure is fixed once it has been developed. In this paper, a modified dynamic evolving neural-fuzzy approach is proposed to address the above mentioned limitations. A case study on the affective design of mobile phones was conducted to illustrate the effectiveness of the proposed methodology. Validation tests were conducted and the test results indicated that: (1) the conventional Adaptive Neuro-Fuzzy Inference System (ANFIS) failed to run due to a large number of inputs; (2) the proposed dynamic neural-fuzzy model outperforms the subtractive clustering-based ANFIS model and fuzzy c-means clustering-based ANFIS model in terms of their modeling accuracy and computational effort.

  16. FISICA observations of the starburst galaxy, NGC 1569

    Science.gov (United States)

    Clark, D. M.; Eikenberry, S. S.; Raines, S. N.; Gruel, N.; Elston, R.; Guzman, R.; Julian, J.; Boreman, G.; Glenn, P. E.; Hull-Allen, C. G.; Hoffman, J.; Rodgers, M.; Thompson, K.; Flint, S.; Comstock, L.; Myrick, B.

    2006-06-01

    Using the Florida Image Slicer for Infrared Cosmology and Astrophysics (FISICA) we obtained observations of the dwarf starburst galaxy NGC 1569. We present our JH band spectra, particularly noting the existence of extended emission in Paschen β and He I.

  17. Emerging trends in evolving networks: Recent behaviour dominant and non-dominant model

    Science.gov (United States)

    Abbas, Khushnood; Shang, Mingsheng; Luo, Xin; Abbasi, Alireza

    2017-10-01

    Novel phenomenon receives similar attention as popular one. Therefore predicting novelty is as important as popularity. Emergence is the side effect of competition and ageing in evolving systems. Recent behaviour or recent link gain in networks plays an important role in emergence. We exploited this wisdom and came up with two models considering different scenarios and systems. Where recent behaviour dominates over total behaviour (total link gain) in the first one, and recent behaviour is as important as total behaviour for future link gain in the second one. It supposes that random walker walks on a network and can jump to any node, the probability of jumping or making a connection to other node is based on which node is recently more active or receiving more links. In our assumption, the random walker can also jump to the node which is already popular but recently not popular. We are able to predict emerging nodes which are generally suppressed under preferential attachment effect. To show the performance of our model we have conducted experiments on four real data sets namely, MovieLens, Netflix, Facebook and Arxiv High Energy Physics paper citation. For testing our model we used four information retrieval indices namely Precision, Novelty, Area Under Receiving Operating Characteristic (AUC) and Kendal's rank correlation coefficient. We have used four benchmark models for validating our proposed models. Although our model does not perform better in all the cases but, it has theoretical significance in working better for recent behaviour dominated systems.

  18. Spatio-temporal modeling of connectome-scale brain network interactions via time-evolving graphs.

    Science.gov (United States)

    Yuan, Jing; Li, Xiang; Zhang, Jinhe; Luo, Liao; Dong, Qinglin; Lv, Jinglei; Zhao, Yu; Jiang, Xi; Zhang, Shu; Zhang, Wei; Liu, Tianming

    2017-11-09

    Many recent literature studies have revealed interesting dynamics patterns of functional brain networks derived from fMRI data. However, it has been rarely explored how functional networks spatially overlap (or interact) and how such connectome-scale network interactions temporally evolve. To explore these unanswered questions, this paper presents a novel framework for spatio-temporal modeling of connectome-scale functional brain network interactions via two main effective computational methodologies. First, to integrate, pool and compare brain networks across individuals and their cognitive states under task performances, we designed a novel group-wise dictionary learning scheme to derive connectome-scale consistent brain network templates that can be used to define the common reference space of brain network interactions. Second, the temporal dynamics of spatial network interactions is modeled by a weighted time-evolving graph, and then a data-driven unsupervised learning algorithm based on the dynamic behavioral mixed-membership model (DBMM) is adopted to identify behavioral patterns of brain networks during the temporal evolution process of spatial overlaps/interactions. Experimental results on the Human Connectome Project (HCP) task fMRI data showed that our methods can reveal meaningful, diverse behavior patterns of connectome-scale network interactions. In particular, those networks' behavior patterns are distinct across HCP tasks such as motor, working memory, language and social tasks, and their dynamics well correspond to the temporal changes of specific task designs. In general, our framework offers a new approach to characterizing human brain function by quantitative description for the temporal evolution of spatial overlaps/interactions of connectome-scale brain networks in a standard reference space. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction.

    Science.gov (United States)

    Belin-Rauscent, Aude; Fouyssac, Maxime; Bonci, Antonello; Belin, David

    2016-01-01

    Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained despite adverse consequences and intense drug craving. The pathophysiology and etiology of addiction is only partially understood despite extensive research because of the gap between current preclinical models of addiction and the clinical criteria of the disorder. This review presents a brief overview, based on selected methodologies, of how behavioral models have evolved over the last 50 years to the development of recent preclinical models of addiction that more closely mimic diagnostic criteria of addiction. It is hoped that these new models will increase our understanding of the complex neurobiological mechanisms whereby some individuals switch from controlled drug use to compulsive drug-seeking habits and relapse to these maladaptive habits. Additionally, by paving the way to bridge the gap that exists between biobehavioral research on addiction and the human situation, these models may provide new perspectives for the development of novel and effective therapeutic strategies for drug addiction. Published by Elsevier Inc.

  20. Universe in the theoretical model «Evolving matter»

    Directory of Open Access Journals (Sweden)

    Bazaluk Oleg

    2013-04-01

    Full Text Available The article critically examines modern model of the Universe evolution constructed by efforts of a group of scientists (mathematicians, physicists and cosmologists from the world's leading universities (Oxford and Cambridge Universities, Yale, Columbia, New York, Rutgers and the UC Santa Cruz. The author notes its strengths, but also points to shortcomings. Author believes that this model does not take into account the most important achievements in the field of biochemistry and biology (molecular, physical, developmental, etc., as well as neuroscience and psychology. Author believes that in the construction of model of the Universe evolution, scientists must take into account (with great reservations the impact of living and intelligent matter on space processes. As an example, the author gives his theoretical model "Evolving matter". In this model, he shows not only the general dependence of the interaction of cosmic processes with inert, living and intelligent matter, but also he attempts to show the direct influence of systems of living and intelligent matter on the acceleration of the Universe's expansion.

  1. Molecular Gasdynamics of the Young Nuclear Starburst in the Barred Galaxy NGC 3504

    Science.gov (United States)

    Kenney, Jeffrey D. P.; Carlstrom, John E.; Young, Judith S.

    1993-12-01

    gravitational instability theory is consistent with ongoing star formation. The radial variation in the cloud growth timescale predicted from a Toomre instability is similar to the radial variation in the gas depletion timescale derived from the Hα/CO ratio, although the timescales differ by a factor of ˜103. Either star formation is surprisingly inefficient, or the cloud collapse timescale is longer than the instability growth timescale We propose that the behavior of star formation for a given value of Q is strongly influenced by the strength of tidal shear, which can help control the star formation rate via the cloud destruction rate. In the central 300 pc of NGC 3504, where the rotation curve is nearly solid body and where the starburst is most intense, a lump of gas with Q ≃ 1 has a density much greater than that which is susceptible to tidal shear. However, 400-600 pc from the center of NGC 3504, where the rotation curve is nearly flat, a lump of gas with Q ≃ 1 has a density close to the range where tidal shear can shred it. A combination of tidal shear and gravitational instability theory can explain why starbursts evolve from the inside out, why evolved starbursts have rings of gas where the rotation curve turns over, and why star formation and the gas supply are regulated to maintain Q ≃ 1 where rotation curves are nearly flat, but may be unregulated where rotation curves are nearly solid body.

  2. Densitometry and Thermometry of Starburst Galaxies

    Science.gov (United States)

    Mangum, J. G.; Darling, J.; Menten, K. M.; Henkel, C.; Aalto, S.; Spaans, M.; van der Werf, P.; Ginsburg, A.; Fomalont, E.; Cotton, B.; Kent, B.

    2015-05-01

    With a goal toward deriving the physical conditions in external galaxies, we have conducted a survey and subsequent high spatial resolution imaging of formaldehyde (H2CO) and ammonia (NH3) emission and absorption in a sample of starburst galaxies. In this article we present the results from a subset of this survey which focuses on high spatial resolution measurements of volume density- and kinetic temperature-sensitive transitions of the H2CO molecule. The volume density structure toward the nuclear region of NGC 253 has been derived from θ ≃ 4 arcsec NRAO Very Large Array (VLA) measurements of the 110 - 111 and 211 - 212 K-doublet transitions of H2CO. The kinetic temperature structure toward NGC 253 and NGC 4945 has been derived from θ ≃ 0.5 - 1.0 arcsec measurements of the H2CO 3K-1K+1 - 2K-1K+1 (near 218 GHz) and 5K-1K+1 - 4K-1K+1 (near 365 GHz) transitions acquired using the Atacama Large Millimeter/submillimeter Array (ALMA). These measurements have allowed us to characterize the dense gas and kinetic temperature structure within these star forming galaxies, which is a first step toward associating dense star-forming gas and the heating processes at work within galaxies.

  3. New constraints on the escape of ionizing photons from starburst galaxies using ionization-parameter mapping

    Energy Technology Data Exchange (ETDEWEB)

    Zastrow, Jordan; Oey, M. S. [Department of Astronomy, University of Michigan, 500 Church Street, 830 Dennison, Ann Arbor, MI 48109-1042 (United States); Veilleux, Sylvain [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); McDonald, Michael, E-mail: jazast@umich.edu [Kavli Institute for Astrophysics and Space Research, MIT, Cambridge, MA 02139 (United States)

    2013-12-10

    The fate of ionizing radiation in starburst galaxies is key to understanding cosmic reionization. However, the galactic parameters on which the escape fraction of ionizing radiation depend are not well understood. Ionization-parameter mapping provides a simple, yet effective, way to study the radiative transfer in starburst galaxies. We obtain emission-line ratio maps of [S III]/[S II] for six, nearby, dwarf starbursts: NGC 178, NGC 1482, NGC 1705, NGC 3125, NGC 7126, and He 2-10. The narrowband images are obtained with the Maryland-Magellan Tunable Filter at Las Campanas Observatory. Using these data, we previously reported the discovery of an optically thin ionization cone in NGC 5253, and here we also discover a similar ionization cone in NGC 3125. This latter cone has an opening angle of 40° ± 5° (0.4 sr), indicating that the passageways through which ionizing radiation may travel correspond to a small solid angle. Additionally, there are three sample galaxies that have winds and/or superbubble activity, which should be conducive to escaping radiation, yet they are optically thick. These results support the scenario that an orientation bias limits our ability to directly detect escaping Lyman continuum in many starburst galaxies. A comparison of the star formation properties and histories of the optically thin and thick galaxies is consistent with the model that high escape fractions are limited to galaxies that are old enough (≳3 Myr) for mechanical feedback to have cleared optically thin passageways in the interstellar medium, but young enough (≲5 Myr) that the ionizing stars are still present.

  4. Can We Recognize an Innovation? Perspective from an Evolving Network Model

    Science.gov (United States)

    Jain, Sanjay; Krishna, Sandeep

    "Innovations" are central to the evolution of societies and the evolution of life. But what constitutes an innovation? We can often agree after the event, when its consequences and impact over a long term are known, whether something was an innovation, and whether it was a "big" innovation or a "minor" one. But can we recognize an innovation "on the fly" as it appears? Successful entrepreneurs often can. Is it possible to formalize that intuition? We discuss this question in the setting of a mathematical model of evolving networks. The model exhibits self-organization , growth, stasis, and collapse of a complex system with many interacting components, reminiscent of real-world phenomena. A notion of "innovation" is formulated in terms of graph-theoretic constructs and other dynamical variables of the model. A new node in the graph gives rise to an innovation, provided it links up "appropriately" with existing nodes; in this view innovation necessarily depends upon the existing context. We show that innovations, as defined by us, play a major role in the birth, growth, and destruction of organizational structures. Furthermore, innovations can be categorized in terms of their graph-theoretic structure as they appear. Different structural classes of innovation have potentially different qualitative consequences for the future evolution of the system, some minor and some major. Possible general lessons from this specific model are briefly discussed.

  5. An evolving model for the lodging-service network in a tourism destination

    Science.gov (United States)

    Hernández, Juan M.; González-Martel, Christian

    2017-09-01

    Tourism is a complex dynamic system including multiple actors which are related each other composing an evolving social network. This paper presents a growing model that explains how part of the supply components in a tourism system forms a social network. Specifically, the lodgings and services in a destination are the network nodes and a link between them appears if a representative tourist hosted in the lodging visits/consumes the service during his/her stay. The specific link between both categories are determined by a random and preferential attachment rule. The analytic results show that the long-term degree distribution of services follows a shifted power-law distribution. The numerical simulations show slight disagreements with the theoretical results in the case of the one-mode degree distribution of services, due to the low order of convergence to zero of X-motifs. The model predictions are compared with real data coming from a popular tourist destination in Gran Canaria, Spain, showing a good agreement between analytical and empirical data for the degree distribution of services. The theoretical model was validated assuming four type of perturbations in the real data.

  6. Winds of change: reionization by starburst galaxies

    Science.gov (United States)

    Sharma, Mahavir; Theuns, Tom; Frenk, Carlos; Bower, Richard G.; Crain, Robert A.; Schaller, Matthieu; Schaye, Joop

    2017-06-01

    We investigate the properties of the galaxies that reionized the Universe and the history of cosmic reionization using the 'Evolution and Assembly of Galaxies and their Environments' (eagle) cosmological hydrodynamical simulations. We obtain the evolution of the escape fraction of ionizing photons in galaxies assuming that galactic winds create channels through which 20 per cent of photons escape when the local surface density of star formation is greater than 0.1 M⊙ yr-1 kpc-2. Such threshold behaviour for the generation of winds is observed, and the rare local objects that have such high star formation surface densities exhibit high escape fractions of ˜10 per cent. In our model, the luminosity-weighted mean escape fraction increases with redshift as \\bar{f}_esc=0.045 ((1+z)/4)^{1.1} at z > 3, and the galaxy number weighted mean as = 2.2 × 10-3 ((1 + z)/4)4, and becomes constant ≈0.2 at redshift z > 10. The escape fraction evolves as an increasingly large fraction of stars forms above the critical surface density of star formation at earlier times. This evolution of the escape fraction, combined with that of the star formation rate density from eagle, reproduces the inferred evolution of the filling factor of ionized regions during the reionization epoch (6 z z < 6) hydrogen photoionization rate and the optical depth due to Thomson scattering of the cosmic microwave background photons measured by the Planck satellite.

  7. A Reproductive Threat-Based Model of Evolved Sex Differences in Jealousy

    Directory of Open Access Journals (Sweden)

    Brad J. Sagarin

    2012-07-01

    Full Text Available Although heterosexual women and men consistently demonstrate sex differences in jealousy, these differences disappear among lesbians and gay men as well as among heterosexual women and men contemplating same-sex infidelities (infidelities in which the partner and rival are the same sex. Synthesizing these past findings, the present paper offers a reproductive threat-based model of evolved sex differences in jealousy that predicts that the sexes will differ only when the jealous perceivers' reproductive outcomes are differentially at risk. This model is supported by data from a web-based study in which lesbians, gay men, bisexual women and men, and heterosexual women and men responded to a hypothetical infidelity scenario with the sex of the rival randomly determined. After reading the scenario, participants indicated which type of infidelity (sexual versus emotional would cause greater distress. Consistent with predictions, heterosexual women and men showed a sex difference when contemplating opposite-sex infidelities but not when contemplating same-sex infidelities, whereas lesbians and gay men showed no sex difference regardless of whether the infidelity was opposite-sex or same-sex.

  8. An evolving model for the supply network in a tourism destination

    CERN Document Server

    Hernández, Juan M

    2016-01-01

    Tourism is a complex dynamic system including multiple actors which are related each other composing an evolving social network. This paper presents a growing bipartite network model that explains the rise of the supply network in a tourism destination from the beginning phases of development. The nodes are the lodgings and services in a destination and a link between them appears if a representative tourist hosted in the lodging visits/consumes the service during his/her stay. The specific link between both categories are determined by a random and preferential attachment rule. The analytic results show that the long-term degree distribution of services follows a shifted power-law distribution. The numerical simulations show slight disagreements with the theoretical results in the case of the one-mode degree distribution of services, due to the low order of convergence to zero of X-motifs. The model predictions are compared with real data coming from a popular tourist destination in Gran Canaria, Spain, show...

  9. Detection of gamma rays from a starburst galaxy.

    Science.gov (United States)

    Acero, F; Aharonian, F; Akhperjanian, A G; Anton, G; Barres de Almeida, U; Bazer-Bachi, A R; Becherini, Y; Behera, B; Bernlöhr, K; Bochow, A; Boisson, C; Bolmont, J; Borrel, V; Brucker, J; Brun, F; Brun, P; Bühler, R; Bulik, T; Büsching, I; Boutelier, T; Chadwick, P M; Charbonnier, A; Chaves, R C G; Cheesebrough, A; Chounet, L-M; Clapson, A C; Coignet, G; Dalton, M; Daniel, M K; Davids, I D; Degrange, B; Deil, C; Dickinson, H J; Djannati-Ataï, A; Domainko, W; Drury, L O'C; Dubois, F; Dubus, G; Dyks, J; Dyrda, M; Egberts, K; Emmanoulopoulos, D; Espigat, P; Farnier, C; Fegan, S; Feinstein, F; Fiasson, A; Förster, A; Fontaine, G; Füssling, M; Gabici, S; Gallant, Y A; Gérard, L; Gerbig, D; Giebels, B; Glicenstein, J F; Glück, B; Goret, P; Göring, D; Hauser, D; Hauser, M; Heinz, S; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hoffmann, A; Hofmann, W; Hofverberg, P; Hoppe, S; Horns, D; Jacholkowska, A; de Jager, O C; Jahn, C; Jung, I; Katarzyński, K; Katz, U; Kaufmann, S; Kerschhaggl, M; Khangulyan, D; Khélifi, B; Keogh, D; Klochkov, D; Kluźniak, W; Kneiske, T; Komin, Nu; Kosack, K; Kossakowski, R; Lamanna, G; Lenain, J-P; Lohse, T; Marandon, V; Martineau-Huynh, O; Marcowith, A; Masbou, J; Maurin, D; McComb, T J L; Medina, M C; Méhault, J; Moderski, R; Moulin, E; Naumann-Godo, M; de Naurois, M; Nedbal, D; Nekrassov, D; Nicholas, B; Niemiec, J; Nolan, S J; Ohm, S; Olive, J-F; de Oña Wilhelmi, E; Orford, K J; Ostrowski, M; Panter, M; Paz Arribas, M; Pedaletti, G; Pelletier, G; Petrucci, P-O; Pita, S; Pühlhofer, G; Punch, M; Quirrenbach, A; Raubenheimer, B C; Raue, M; Rayner, S M; Reimer, O; Renaud, M; Rieger, F; Ripken, J; Rob, L; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Ruppel, J; Sahakian, V; Santangelo, A; Schlickeiser, R; Schöck, F M; Schwanke, U; Schwarzburg, S; Schwemmer, S; Shalchi, A; Sikora, M; Skilton, J L; Sol, H; Stawarz, Ł; Steenkamp, R; Stegmann, C; Stinzing, F; Superina, G; Szostek, A; Tam, P H; Tavernet, J-P; Terrier, R; Tibolla, O; Tluczykont, M; van Eldik, C; Vasileiadis, G; Venter, C; Venter, L; Vialle, J P; Vincent, P; Vivier, M; Völk, H J; Volpe, F; Wagner, S J; Ward, M; Zdziarski, A A; Zech, A

    2009-11-20

    Starburst galaxies exhibit in their central regions a highly increased rate of supernovae, the remnants of which are thought to accelerate energetic cosmic rays up to energies of approximately 10(15) electron volts. We report the detection of gamma rays--tracers of such cosmic rays--from the starburst galaxy NGC 253 using the High Energy Stereoscopic System (H.E.S.S.) array of imaging atmospheric Cherenkov telescopes. The gamma-ray flux above 220 billion electron volts is F = (5.5 +/- 1.0(stat) +/- 2.8(sys)) x 10(-13) cm(-2) s(-1), implying a cosmic-ray density about three orders of magnitude larger than that in the center of the Milky Way. The fraction of cosmic-ray energy channeled into gamma rays in this starburst environment is five times as large as that in our Galaxy.

  10. The basic postulates of the universal evolution model «Evolving matter»

    Directory of Open Access Journals (Sweden)

    Bazaluk Oleg

    2015-02-01

    Full Text Available The author reveals the features of construction of the universal evolution model, which he called «Evolving matter». According to the author, the material world, which is perceived in scales of the Earth and near space, consists of visually and empirically easily detectable states of matter, with different complexity of the internal organisation: inert, living and intelligent matter. The transition from one («parent» state of matter to another («daughter» state is caused by three main factors and two reasons of evolution. The author has carried the following factors of evolution as a complication: a Continuity of self-complication structures, types of interaction and environments of existence of any state of matter, which is supplemented by: – Block of continuous self-complication; – Principle of block of continuous self-complication of dominance; b Nonlinear complication of structure, types of interactions and environments of existence of any state of matter, which is specified by factors: – Hierarchical nonlinear complication; – Orientation of nonlinear hierarchical complication; c Complication isolation. The author carries complications to the evolution reasons: a Active principle, which is inherently the basis for the initial elements of any state of matter, and which forms a self-complication; b Natural selection as the environment influence.

  11. The Cardiovascular Intensive Care Unit-An Evolving Model for Health Care Delivery.

    Science.gov (United States)

    Loughran, John; Puthawala, Tauqir; Sutton, Brad S; Brown, Lorrel E; Pronovost, Peter J; DeFilippis, Andrew P

    2017-02-01

    Prior to the advent of the coronary care unit (CCU), patients having an acute myocardial infarction (AMI) were managed on the general medicine wards with reported mortality rates of greater than 30%. The first CCUs are believed to be responsible for reducing mortality attributed to AMI by as much as 40%. This drastic improvement can be attributed to both advances in medical technology and in the process of health care delivery. Evolving considerably since the 1960s, the CCU is now more appropriately labeled as a cardiac intensive care unit (CICU) and represents a comprehensive system designed for the care of patients with an array of advanced cardiovascular disease, an entity that reaches far beyond its early association with AMI. Grouping of patients by diagnosis to a common physical space, dedicated teams of health care providers, as well as the development and implementation of evidence-based treatment algorithms have resulted in the delivery of safer, more efficient care, and most importantly better patient outcomes. The CICU serves as a platform for an integrated, team-based patient care delivery system that addresses a broad spectrum of patient needs. Lessons learned from this model can be broadly applied to address the urgent need to improve outcomes and efficiency in a variety of health care settings.

  12. Evolving a Simulation Model Product Line Software Architecture from Heterogeneous Model Representations

    Science.gov (United States)

    2003-09-01

    Crouching Dragon , Hidden Software: Software in DoD Weapon Systems,” IEEE Software, Vol. 18, No. 4, July-August 2001, pp. 105-107. [FG99...objects hidden , Generalization is a form of abstraction establishing an is-a relationship between the specialized and generic object, when similar...concept, [CGG98] explained the JSIMS Military Modeling Framework initiative, a De- partment enterprise-wide Tiger Team initiative to develop Mission

  13. Evolving models for medical physics education and training: a global perspective.

    Science.gov (United States)

    Sprawls, P

    2008-01-01

    There is a significant need for high-quality medical physics education and training in all countries to support effective and safe use of modern medical technology for both diagnostic and treatment purposes. This is, and will continue to be, achieved using appropriate technology to increase both the effectiveness and efficiency of educational activities everywhere in the world. While the applications of technology to education and training are relatively new, the successful applications are based on theories and principles of the learning process developed by two pioneers in the field, Robert Gagne and Edgar Dale.The work of Gagne defines the different levels of learning that can occur and is used to show the types and levels of learning that are required for the application of physics and engineering principles to achieve appropriate diagnostic and therapeutic results from modern technology. The learning outcomes are determined by the effectiveness of the learning activity or experience. The extensive work of Dale as formulated in his Cone of Experience relates the effectiveness to the efficiency of educational activities. A major challenge in education is the development and conduction of learning activities (classroom discussions, laboratory and applied experiences, individual study, etc) that provide an optimum balance between effectiveness and efficiency. New and evolving models of the educational process use technology as the infrastructure to support education that is both more effective and efficient.The goal is to use technology to enhance human performance for both learners (students) and learning facilitators (teachers). A major contribution to global education is the trend in the development of shared educational resources. Two models of programs to support this effort with open and free shared resources are Physical Principles of Medical Imaging Online (http://www.sprawls.org/resources) and AAPM Continuing Education Courses (http://www.aapm.org/international).

  14. Generational dermatology: model for prevention and multi decade approach toward the evolving, aging patient.

    Science.gov (United States)

    Roberts, Wendy E

    2013-12-01

    The proposed terminology Generational Dermatology encompasses prevention and involves medical, cosmetic, surgical and oncologic strategies over the decades to optimize skin performance throughout the course of a lifetime. Organ failure is the inability of the organ to perform its determined function as a part of normal physiology and it may be possible to take a Generational preventive approach toward reducing morbidities associated with the failure of our largest organ, the skin. Outside of skin cancer prevention efforts we have as a specialty primarily worked on the tertiary prevention realm. I advocate that we can increase our focus on the primary and secondary tiers where we as Dermatologists have the training and education to identify risk factors and detect early symptoms of skin disease. I appeal to the house of Dermatology to embrace this concept of Generational Dermatology as preventive medicine for the evolving aging patient. The practice of Generational Dermatology will decrease patient morbidity and bring down the cost of healthcare. Our global increased longevity increases the number of elderly worldwide. Longer lifespan means dermatologic needs will increase as the skin must perform its basic function longer. There are also new unknowns and skin issues which arise from large numbers of people in the 9th and 10th decades. Generational Dermatology is well suited to be a model for prevention as our patient's age and we can intervene at any decade. I believe the specialty will increasingly focus on how the skin can optimally perform for a longer period. Lastly, the practice of Generational Dermatology unifies the house of Dermatology as we need the innovations and input of every subspecialty to contribute to the health of the people we serve.

  15. Hα Emission Line Morphologies in Markarian Starburst Galaxies A ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging Solutions)

    tribution of hot, young stars in star forming regions of normal and starburst galaxies. Extensive Hα surveys of samples of normal galaxies were carried out by Kennicutt &. Kent (1983). They found that the integrated emission of a galaxy is strongly correlated with its Hubble type and colour. They also inferred that the variation ...

  16. THE PROPERTIES OF POST-STARBURST QUASARS BASED ON OPTICAL SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Cales, Sabrina L. [Departamento de Astronomia, Universidad de Concepcion, Casilla 160-C, Concepcion (Chile); Brotherton, Michael S.; Shang, Zhaohui; Runnoe, Jessie C.; DiPompeo, Michael A., E-mail: scales@astro-udec.cl, E-mail: scales@uwyo.edu, E-mail: mbrother@uwyo.edu, E-mail: shang@uwyo.edu, E-mail: jrunnoe@uwyo.edu, E-mail: mdipompe@uwyo.edu [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); and others

    2013-01-10

    We present optical spectroscopy of a sample of 38 post-starburst quasars (PSQs) at z {approx} 0.3, 29 of which have morphological classifications based on Hubble Space Telescope imaging. These broad-lined active galactic nuclei (AGNs) possess the spectral signatures of massive intermediate-aged stellar populations, making them potentially useful for studying connections between nuclear activity and host galaxy evolution. We model the spectra in order to determine the ages and masses of the host stellar populations, and the black hole masses and Eddington fractions of the AGNs. Our model components include an instantaneous starburst, a power law, and emission lines. We find that the PSQs have M {sub BH} {approx} 10{sup 8} M {sub Sun} accreting at a few percent of Eddington luminosity and host {approx}10{sup 10.5} M {sub Sun} stellar populations which are several hundred Myr to a few Gyr old. We investigate relationships among these derived properties, spectral properties, and morphologies. We find that PSQs hosted in spiral galaxies have significantly weaker AGN luminosities, older starburst ages, and narrow emission-line ratios diagnostic of ongoing star formation when compared to their early-type counterparts. We conclude that the early-type PSQs are likely the result of major mergers and were likely luminous infrared galaxies in the past, while spiral PSQs with more complex star formation histories are triggered by less dramatic events (e.g., harassment, bars). We provide diagnostics to distinguish the early-type and spiral hosts when high spatial resolution imaging is not available.

  17. CLUMPY AND EXTENDED STARBURSTS IN THE BRIGHTEST UNLENSED SUBMILLIMETER GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Iono, Daisuke; Hatsukade, Bunyo; Kawabe, Ryohei; Matsuda, Yuichi; Nakanishi, Kouichiro [National Astronomical Observatory of Japan, National Institutes of Natural Sciences, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Yun, Min S.; Wilson, Grant [University of Massachusetts, Department of Astronomy, 710 North Pleasant Street, Amherst, MA 01003 (United States); Aretxaga, Itziar; Hughes, David [Instituto Nacional de Astrofisica, Optica y Electronica (INAOE), Luis Enrique Erro 1, Sta. Ma. Tonantzintla, Puebla (Mexico); Ikarashi, Soh [Kapteyn Astronomical Institute, University of Groningen, P.O. Box 800, 9700AV Groningen (Netherlands); Izumi, Takuma; Kohno, Kotaro; Tamura, Yoichi; Umehata, Hideki [Institute of Astronomy, The University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Lee, Minju; Saito, Toshiki [Department of Astronomy, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 133-0033 (Japan); Ueda, Junko [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Michiyama, Tomonari; Ando, Misaki, E-mail: d.iono@nao.ac.jp [SOKENDAI (The Graduate University for Advanced Studies), 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)

    2016-09-20

    The central structure in three of the brightest unlensed z = 3–4 submillimeter galaxies is investigated through 0.″015–0.″05 (120–360 pc) 860 μ m continuum images obtained using the Atacama Large Millimeter/submillimeter Array (ALMA). The distribution in the central kiloparsec in AzTEC1 and AzTEC8 is extremely complex, and they are composed of multiple ∼200 pc clumps. AzTEC4 consists of two sources that are separated by ∼1.5 kpc, indicating a mid-stage merger. The peak star formation rate densities in the central clumps are ∼300–3000 M {sub ⊙} yr{sup −1} kpc{sup −2}, suggesting regions with extreme star formation near the Eddington limit. By comparing the flux obtained by ALMA and Submillimeter Array, we find that 68%–90% of the emission is extended (≳1 kpc) in AzTEC4 and 8. For AzTEC1, we identify at least 11 additional compact (∼200 pc) clumps in the extended 3–4 kpc region. Overall, the data presented here suggest that the luminosity surface densities observed at ≲150 pc scales are roughly similar to that observed in local ULIRGs, as in the eastern nucleus of Arp 220. Between 10% and 30% of the 860 μ m continuum is concentrated in clumpy structures in the central kiloparsec, while the remaining flux is distributed over ≳1 kpc regions, some of which could also be clumpy. These sources can be explained by a rapid inflow of gas such as a merger of gas-rich galaxies, surrounded by extended and clumpy starbursts. However, the cold mode accretion model is not ruled out.

  18. Generation of predictive price and trading volume patterns in a model of dynamically evolving free market supply and demand

    Directory of Open Access Journals (Sweden)

    J. K. Wang

    2001-01-01

    Full Text Available I present a model of stock market price fluctuations incorporating effects of share supply as a history-dependent function of previous purchases and share demand as a function of price deviation from moving averages. Price charts generated show intervals of oscillations switching amplitude and frequency suddenly in time, forming price and trading volume patterns well-known in market technical analysis. Ultimate price trends agree with traditional predictions for specific patterns. The consideration of dynamically evolving supply and demand in this model resolves the apparent contradiction with the Efficient Market Hypothesis: perceptions of imprecise equity values by a world of investors evolve over non-negligible periods of time, with dependence on price history.

  19. Gamma-rays from pulsar wind nebulae in starburst galaxies

    Science.gov (United States)

    Mannheim, Karl; Elsässer, Dominik; Tibolla, Omar

    2012-07-01

    Recently, gamma-ray emission at TeV energies has been detected from the starburst galaxies NGC253 (Acero et al., 2009) [1] and M82 (Acciari et al., 2009) [2]. It has been claimed that pion production due to cosmic rays accelerated in supernova remnants interacting with the interstellar gas is responsible for the observed gamma rays. Here, we show that the gamma-ray pulsar wind nebulae left behind by the supernovae contribute to the TeV luminosity in a major way. A single pulsar wind nebula produces about ten times the total luminosity of the Sun at energies above 1 TeV during a lifetime of 105 years. A large number of 3 × 104 pulsar wind nebulae expected in a typical starburst galaxy at a distance of 4 Mpc can readily produce the observed TeV gamma rays.

  20. Scaling Relations of Starburst-driven Galactic Winds

    Science.gov (United States)

    Tanner, Ryan; Cecil, Gerald; Heitsch, Fabian

    2017-07-01

    Using synthetic absorption lines generated from 3D hydrodynamical simulations, we explore how the velocity of a starburst-driven galactic wind correlates with the star formation rate (SFR) and SFR density. We find strong correlations for neutral and low ionized gas, but no correlation for highly ionized gas. The correlations for neutral and low ionized gas only hold for SFRs below a critical limit set by the mass loading of the starburst, above which point the scaling relations flatten abruptly. Below this point the scaling relations depend on the temperature regime being probed by the absorption line, not on the mass loading. The exact scaling relation depends on whether the maximum or mean velocity of the absorption line is used. We find that the outflow velocity of neutral gas can be up to five times lower than the average velocity of ionized gas, with the velocity difference increasing for higher ionization states. Furthermore, the velocity difference depends on both the SFR and mass loading of the starburst. Thus, absorption lines of neutral or low ionized gas cannot easily be used as a proxy for the outflow velocity of the hot gas.

  1. ALMA Resolves the Molecular Gas in a Young Low-metallicity Starburst Galaxy at z = 1.7

    Science.gov (United States)

    González-López, Jorge; Barrientos, L. Felipe; Gladders, M. D.; Wuyts, Eva; Rigby, Jane; Sharon, Keren; Aravena, Manuel; Bayliss, Matthew B.; Ibar, Eduardo

    2017-09-01

    We present Atacama Large Millimeter/submillimeter Array observations of CO lines and dust continuum emission of the source RCSGA 032727-132609, a young z = 1.7 low-metallicity starburst galaxy. The CO(3-2) and CO(6-5) lines and continuum at rest-frame 450 μm are detected and show a resolved structure in the image plane. We use the corresponding lensing model to obtain a source plane reconstruction of the detected emissions revealing an intrinsic flux density of {S}450μ {{m}}={23.5}-8.1+26.8 μJy and intrinsic CO luminosities {L}{CO(3-2)}{\\prime }={2.90}-0.23+0.21 × {10}8 {{K}} {km} {{{s}}}-1 {{pc}}2 and {L}{CO(6-5)}{\\prime }={8.0}-1.3+1.4× {10}7 {{K}} {km} {{{s}}}-1 {{pc}}2. We used the resolved properties in the source plane to obtain molecular gas and star formation rate surface densities of {{{Σ }}}{{H}2}={16.2}-3.5+5.8 {M}⊙ {{pc}}-2 and {{{Σ }}}{SFR}={0.54}-0.27+0.89 {M}⊙ {{yr}}-1 {{kpc}}-2, respectively. The intrinsic properties of RCSGA 032727-132609 show an enhanced star formation activity compared to local spiral galaxies with similar molecular gas densities, supporting the ongoing merger-starburst phase scenario. RCSGA 032727-132609 also appears to be a low-density starburst galaxy similar to local blue compact dwarf galaxies, which have been suggested as local analogs to high-redshift low-metallicity starburst systems. Finally, the CO excitation level in the galaxy is consistent with having the peak at J˜ 5, with a higher excitation concentrated in the star-forming clumps.

  2. Mentoring: An Evolving Relationship.

    Science.gov (United States)

    Block, Michelle; Florczak, Kristine L

    2017-04-01

    The column concerns itself with mentoring as an evolving relationship between mentor and mentee. The collegiate mentoring model, the transformational transcendence model, and the humanbecoming mentoring model are considered in light of a dialogue with mentors at a Midwest university and conclusions are drawn.

  3. Maintaining evolvability.

    Science.gov (United States)

    Crow, James F

    2008-12-01

    Although molecular methods, such as QTL mapping, have revealed a number of loci with large effects, it is still likely that the bulk of quantitative variability is due to multiple factors, each with small effect. Typically, these have a large additive component. Conventional wisdom argues that selection, natural or artificial, uses up additive variance and thus depletes its supply. Over time, the variance should be reduced, and at equilibrium be near zero. This is especially expected for fitness and traits highly correlated with it. Yet, populations typically have a great deal of additive variance, and do not seem to run out of genetic variability even after many generations of directional selection. Long-term selection experiments show that populations continue to retain seemingly undiminished additive variance despite large changes in the mean value. I propose that there are several reasons for this. (i) The environment is continually changing so that what was formerly most fit no longer is. (ii) There is an input of genetic variance from mutation, and sometimes from migration. (iii) As intermediate-frequency alleles increase in frequency towards one, producing less variance (as p --> 1, p(1 - p) --> 0), others that were originally near zero become more common and increase the variance. Thus, a roughly constant variance is maintained. (iv) There is always selection for fitness and for characters closely related to it. To the extent that the trait is heritable, later generations inherit a disproportionate number of genes acting additively on the trait, thus increasing genetic variance. For these reasons a selected population retains its ability to evolve. Of course, genes with large effect are also important. Conspicuous examples are the small number of loci that changed teosinte to maize, and major phylogenetic changes in the animal kingdom. The relative importance of these along with duplications, chromosome rearrangements, horizontal transmission and polyploidy

  4. Numerically modelling the Cygnus Loop as a remnant evolved in an anisotropic cavity

    Science.gov (United States)

    Fang, Jun; Yu, Huan; Zhang, Li

    2017-01-01

    The morphology of the middle-aged supernova remnant, Cygnus Loop, seen in X-rays, is peculiar, with a blowout in the south region and other irregular features, such as a bump in the west, a limb with a planar morphology in the east and asymmetry between the east and the west shock profiles of the blowout. The detailed process of the formation of the peculiar profile of the shock is still unclear. We perform three-dimensional hydrodynamical simulations for the remnant to revisit its evolution. In the simulations, the progenitor ejects an anisotropic, latitude-dependent wind, and travels in a direction that is not aligned with the symmetry axis of the wind. As a result, a cavity with a fringed structure is produced. The remnant has evolved in the cavity for about 104 yr. In the north-east, the shock has first encountered the bow shock, and this part corresponds to the bright north-eastern region. The south blowout is formed due to the shock travelling into the undisturbed wind, and the interaction of the shock with the cavity leads to the other peculiar features of the shock structure. The resulting profile of the remnant is consistent with that indicated in X-rays. It can be concluded that the supernova explosion occurred in the cavity produced by an anisotropic stellar wind experiencing two main phases with different wind velocities.

  5. Scalable geocomputation: evolving an environmental model building platform from single-core to supercomputers

    Science.gov (United States)

    Schmitz, Oliver; de Jong, Kor; Karssenberg, Derek

    2017-04-01

    There is an increasing demand to run environmental models on a big scale: simulations over large areas at high resolution. The heterogeneity of available computing hardware such as multi-core CPUs, GPUs or supercomputer potentially provides significant computing power to fulfil this demand. However, this requires detailed knowledge of the underlying hardware, parallel algorithm design and the implementation thereof in an efficient system programming language. Domain scientists such as hydrologists or ecologists often lack this specific software engineering knowledge, their emphasis is (and should be) on exploratory building and analysis of simulation models. As a result, models constructed by domain specialists mostly do not take full advantage of the available hardware. A promising solution is to separate the model building activity from software engineering by offering domain specialists a model building framework with pre-programmed building blocks that they combine to construct a model. The model building framework, consequently, needs to have built-in capabilities to make full usage of the available hardware. Developing such a framework providing understandable code for domain scientists and being runtime efficient at the same time poses several challenges on developers of such a framework. For example, optimisations can be performed on individual operations or the whole model, or tasks need to be generated for a well-balanced execution without explicitly knowing the complexity of the domain problem provided by the modeller. Ideally, a modelling framework supports the optimal use of available hardware whichsoever combination of model building blocks scientists use. We demonstrate our ongoing work on developing parallel algorithms for spatio-temporal modelling and demonstrate 1) PCRaster, an environmental software framework (http://www.pcraster.eu) providing spatio-temporal model building blocks and 2) parallelisation of about 50 of these building blocks using

  6. Characteristics of evolving models of care for arthritis: A key informant study

    Directory of Open Access Journals (Sweden)

    Veinot Paula

    2008-07-01

    Full Text Available Abstract Background The burden of arthritis is increasing in the face of diminishing health human resources to deliver care. In response, innovative models of care delivery are developing to facilitate access to quality care. Most models have developed in response to local needs with limited evaluation. The primary objective of this study is to a examine the range of models of care that deliver specialist services using a medical/surgical specialist and at least one other health care provider and b document the strengths and challenges of the identified models. A secondary objective is to identify key elements of best practice models of care for arthritis. Methods Semi-structured interviews were conducted with a sample of key informants with expertise in arthritis from jurisdictions with primarily publicly-funded health care systems. Qualitative data were analyzed using a constant comparative approach to identify common types of models of care, strengths and challenges of models, and key components of arthritis care. Results Seventy-four key informants were interviewed from six countries. Five main types of models of care emerged. 1 Specialized arthritis programs deliver comprehensive, multidisciplinary team care for arthritis. Two models were identified using health care providers (e.g. nurses or physiotherapists in expanded clinical roles: 2 triage of patients with musculoskeletal conditions to the appropriate services including specialists; and 3 ongoing management in collaboration with a specialist. Two models promoting rural access were 4 rural consultation support and 5 telemedicine. Key informants described important components of models of care including knowledgeable health professionals and patients. Conclusion A range of models of care for arthritis have been developed. This classification can be used as a framework for discussing care delivery. Areas for development include integration of care across the continuum, including primary

  7. Beyond Dyadic Interdependence: Actor-Oriented Models for Co-Evolving Social Networks and Individual Behaviors

    Science.gov (United States)

    Burk, William J.; Steglich, Christian E. G.; Snijders, Tom A. B.

    2007-01-01

    Actor-oriented models are described as a longitudinal strategy for examining the co-evolution of social networks and individual behaviors. We argue that these models provide advantages over conventional approaches due to their ability to account for inherent dependencies between individuals embedded in a social network (i.e., reciprocity,…

  8. GIANT Hα NEBULA SURROUNDING THE STARBURST MERGER NGC 6240

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Michitoshi [Hiroshima Astrophysical Science Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Yagi, Masafumi; Komiyama, Yutaka; Kashikawa, Nobunari [Optical and Infrared Astronomy Division, National Astronomical Observatory, Mitaka, Tokyo 181-8588 (Japan); Ohyama, Youichi [Institute of Astronomy and Astrophysics, Academia Sinica, 11F of Astronomy-Mathematics Building, AS/NTU No.1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan, R.O.C. (China); Tanaka, Hisashi [Department of Physical Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Okamura, Sadanori, E-mail: yoshidam@hiroshima-u.ac.jp [Department of Advanced Sciences, Faculty of Science and Engineering, Hosei University, Koganei, Tokyo 184-8584 (Japan)

    2016-03-20

    We revealed the detailed structure of a vastly extended Hα-emitting nebula (“Hα nebula”) surrounding the starburst/merging galaxy NGC 6240 by deep narrow-band imaging observations with the Subaru Suprime-Cam. The extent of the nebula is ∼90 kpc in diameter and the total Hα luminosity amounts to L{sub Hα} ≈ 1.6 × 10{sup 42} erg s{sup −1}. The volume filling factor and the mass of the warm ionized gas are ∼10{sup −4}–10{sup −5} and ∼5 × 10{sup 8} M{sub ⊙}, respectively. The nebula has a complicated structure, which includes numerous filaments, loops, bubbles, and knots. We found that there is a tight spatial correlation between the Hα nebula and the extended soft-X-ray-emitting gas, both in large and small scales. The overall morphology of the nebula is dominated by filamentary structures radially extending from the center of the galaxy. A large-scale bipolar bubble extends along the minor axis of the main stellar disk. The morphology strongly suggests that the nebula was formed by intense outflows—superwinds—driven by starbursts. We also found three bright knots embedded in a looped filament of ionized gas that show head-tail morphologies in both emission-line and continuum, suggesting close interactions between the outflows and star-forming regions. Based on the morphology and surface brightness distribution of the Hα nebula, we propose the scenario that three major episodes of starburst/superwind activities, which were initiated ∼10{sup 2} Myr ago, formed the extended ionized gas nebula of NGC 6240.

  9. STELLAR POPULATION AND GAS KINEMATICS OF POST-STARBURST QUASARS

    Science.gov (United States)

    Sanmartim, David; Storchi-Bergmann, Thaisa

    2018-01-01

    Post-Starburst Quasars (PSQs) are an intriguing set of galaxies that simultaneously host AGNs and post-starburst stellar populations, making them one of the most suitable objects to investigate the nature of the connection between these two components. The simultaneous presence of a post-starburst population and nuclear activity may be explained by two possible scenarios. In the secular evolutionary scenario star formation may cease due to exhaustion of the gas, while in the quenching one it may cease abruptly when the nuclear activity is triggered. In order to test these scenarios we have mapped the star formation history, manifestations of nuclear activity and excitation mechanisms in the central kpc of two nearby PSQs by using GMOS-IFU observations. In these two first exploratory studies, we have found that the young and intermediate age populations are located in a ring at ≈300-500 kpc, with some contribution of the intermediate age component also in the central region. In both of them, the gas outflow does not coincide with the young stellar population ring, which suggests that the ring is not being affected by the AGN feedback, but only the innermost regions. The individual study one of the PSQs of the sample has supported the evolutionary scenario, since the post-starburst population is not located close enough to the nucleus, where the outflow is observed. As a general behaviour, we found that outflows velocity are on the order of ~600-800 km/s and the mass outflow rates of ≈0.03-0.1 M⊙/yr, one order of magnitude greater than the AGN accretion rate, which suggests a scenario where the AGN-driven wind has entrained material from the circumnuclear region. In order to increase the statistical significance of our previous results and to distinguish between the proposed scenarios, we are conducting the same analysis to a wider sample of PSQs, which we hope will indicate more conclusively which is the favored scenario. During the meeting, we will present

  10. Opsins have evolved under the permanent heterozygote model: insights from phylotranscriptomics of Odonata.

    Science.gov (United States)

    Suvorov, Anton; Jensen, Nicholas O; Sharkey, Camilla R; Fujimoto, M Stanley; Bodily, Paul; Wightman, Haley M Cahill; Ogden, T Heath; Clement, Mark J; Bybee, Seth M

    2017-03-01

    Gene duplication plays a central role in adaptation to novel environments by providing new genetic material for functional divergence and evolution of biological complexity. Several evolutionary models have been proposed for gene duplication to explain how new gene copies are preserved by natural selection, but these models have rarely been tested using empirical data. Opsin proteins, when combined with a chromophore, form a photopigment that is responsible for the absorption of light, the first step in the phototransduction cascade. Adaptive gene duplications have occurred many times within the animal opsins' gene family, leading to novel wavelength sensitivities. Consequently, opsins are an attractive choice for the study of gene duplication evolutionary models. Odonata (dragonflies and damselflies) have the largest opsin repertoire of any insect currently known. Additionally, there is tremendous variation in opsin copy number between species, particularly in the long-wavelength-sensitive (LWS) class. Using comprehensive phylotranscriptomic and statistical approaches, we tested various evolutionary models of gene duplication. Our results suggest that both the blue-sensitive (BS) and LWS opsin classes were subjected to strong positive selection that greatly weakens after multiple duplication events, a pattern that is consistent with the permanent heterozygote model. Due to the immense interspecific variation and duplicability potential of opsin genes among odonates, they represent a unique model system to test hypotheses regarding opsin gene duplication and diversification at the molecular level. © 2016 John Wiley & Sons Ltd.

  11. A Plate Tectonic Model for the Neoproterozoic with Evolving Plate Boundaries

    Science.gov (United States)

    Merdith, Andrew; Collins, Alan; Williams, Simon; Pisarevsky, Sergei; Müller, Dietmar

    2017-04-01

    The Neoproterozoic was dominated by the formation of the supercontinent Rodinia, its break-up and the subsequent amalgamation of Gondwana, during which, the planet experienced large climatic variations and the emergence of complex life. Here we present a topological plate model of the Neoproterozoic based on a synthesis of available geological and palaeomagnetic data. Subduction zones, which are well preserved in the geological record, are used as a proxy for convergent margins; evidence for mid-ocean ridges and transform motion is less clearly preserved, though passive margins are used as a proxy for spreading centres, and evidence for strike-slip motions are used to model transform boundaries. We find that the model presented here only predicts 70% of the total length of subduction active today, though it models similar lengths of both transform and divergent boundaries, suggesting that we have produced a conservative model and are probably underestimating the amount of subduction. Where evidence for convergent, divergent or transform motion is not preserved, we interpret the locations of plate boundaries based on the relative motions of cratonic crust as suggested through either palaeomagnetic data or the geological record. Using GPlates, we tie these boundaries together to generate a plate model that depicts the motion of tectonic plates through the Neoproterozoic. We omit India and South China from Rodinia completely, due to long-lived subduction preserved on margins of India and conflicting palaeomagnetic data for the Cryogenian, but tie them together due to similar Tonian aged accretionary patterns along their respective (present-day) north-western and northern margins, such that these two cratons act as a "lonely wanderer" for much of the Neoproterozoic, and form their own tectonic plate. We also introduce a Tonian-Cryogenian aged rotation of the Congo-São Francisco Craton relative to Rodinia to better fit palaeomagnetic data and account for thick passive

  12. THE NATURE OF STARBURSTS. III. THE SPATIAL DISTRIBUTION OF STAR FORMATION

    Energy Technology Data Exchange (ETDEWEB)

    McQuinn, Kristen B. W.; Skillman, Evan D. [Minnesota Institute for Astrophysics, School of Physics and Astronomy, 116 Church Street, S.E., University of Minnesota, Minneapolis, MN 55455 (United States); Dalcanton, Julianne J.; Weisz, Daniel R.; Williams, Benjamin F. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Cannon, John M. [Department of Physics and Astronomy, Macalester College, 1600 Grand Avenue, Saint Paul, MN 55105 (United States); Dolphin, Andrew E. [Raytheon Company, 1151 E. Hermans Road, Tucson, AZ 85756 (United States); Holtzman, Jon, E-mail: kmcquinn@astro.umn.edu [Department of Astronomy, New Mexico State University, Box 30001-Department 4500, 1320 Frenger Street, Las Cruces, NM 88003 (United States)

    2012-11-01

    We map the spatial distribution of recent star formation over a few Multiplication-Sign 100 Myr timescales in 15 starburst dwarf galaxies using the location of young blue helium burning stars identified from optically resolved stellar populations in archival Hubble Space Telescope observations. By comparing the star formation histories from both the high surface brightness central regions and the diffuse outer regions, we measure the degree to which the star formation has been centrally concentrated during the galaxies' starbursts, using three different metrics for the spatial concentration. We find that the galaxies span a full range in spatial concentration, from highly centralized to broadly distributed star formation. Since most starbursts have historically been identified by relatively short timescale star formation tracers (e.g., H{alpha} emission), there could be a strong bias toward classifying only those galaxies with recent, centralized star formation as starbursts, while missing starbursts that are spatially distributed.

  13. Direct numerical simulations and modeling of a spatially-evolving turbulent wake

    Science.gov (United States)

    Cimbala, John M.

    1994-12-01

    Understanding of turbulent free shear flows (wakes, jets, and mixing layers) is important, not only for scientific interest, but also because of their appearance in numerous practical applications. Turbulent wakes, in particular, have recently received increased attention by researchers at NASA Langley. The turbulent wake generated by a two-dimensional airfoil has been selected as the test-case for detailed high-resolution particle image velocimetry (PIV) experiments. This same wake has also been chosen to enhance NASA's turbulence modeling efforts. Over the past year, the author has completed several wake computations, while visiting NASA through the 1993 and 1994 ASEE summer programs, and also while on sabbatical leave during the 1993-94 academic year. These calculations have included two-equation (K-omega and K-epsilon) models, algebraic stress models (ASM), full Reynolds stress closure models, and direct numerical simulations (DNS). Recently, there has been mutually beneficial collaboration of the experimental and computational efforts. In fact, these projects have been chosen for joint presentation at the NASA Turbulence Peer Review, scheduled for September 1994. DNS calculations are presently underway for a turbulent wake at Re(sub theta) = 1000 and at a Mach number of 0.20. (Theta is the momentum thickness, which remains constant in the wake of a two dimensional body.) These calculations utilize a compressible DNS code written by M. M. Rai of NASA Ames, and modified for the wake by J. Cimbala. The code employs fifth-order accurate upwind-biased finite differencing for the convective terms, fourth-order accurate central differencing for the viscous terms, and an iterative-implicit time-integration scheme. The computational domain for these calculations starts at x/theta = 10, and extends to x/theta = 610. Fully developed turbulent wake profiles, obtained from experimental data from several wake generators, are supplied at the computational inlet, along with

  14. A model study of mixing and entrainment in the horizontally evolving atmospheric convective boundary layer

    Energy Technology Data Exchange (ETDEWEB)

    Fedorovich, E.; Kaiser, R. [Univ. Karlsruhe, Inst. fuer Hydrologie und Wasserwirtschaft (Germany)

    1997-10-01

    We present results from a parallel wind-tunnel/large-eddy simulation (LES) model study of mixing and entrainment in the atmospheric convective boundary layer (CBL) longitudinally developing over a heated surface. The advection-type entrainment of warmer air from upper turbulence-free layers into the growing CBL has been investigated. Most of numerical and laboratory model studies of the CBL carried out so far dealt with another type of entrainment, namely the non-steady one, regarding the CBL growth as a non-stationary process. In the atmosphere, both types of the CBL development can take place, often being superimposed. (au)

  15. Evolving Transcription Factor Binding Site Models From Protein Binding Microarray Data

    KAUST Repository

    Wong, Ka-Chun

    2016-02-02

    Protein binding microarray (PBM) is a high-throughput platform that can measure the DNA binding preference of a protein in a comprehensive and unbiased manner. In this paper, we describe the PBM motif model building problem. We apply several evolutionary computation methods and compare their performance with the interior point method, demonstrating their performance advantages. In addition, given the PBM domain knowledge, we propose and describe a novel method called kmerGA which makes domain-specific assumptions to exploit PBM data properties to build more accurate models than the other models built. The effectiveness and robustness of kmerGA is supported by comprehensive performance benchmarking on more than 200 datasets, time complexity analysis, convergence analysis, parameter analysis, and case studies. To demonstrate its utility further, kmerGA is applied to two real world applications: 1) PBM rotation testing and 2) ChIP-Seq peak sequence prediction. The results support the biological relevance of the models learned by kmerGA, and thus its real world applicability.

  16. Time-Evolving Acoustic Propagation Modeling in a Complex Ocean Environment

    NARCIS (Netherlands)

    Colin, M.E.G.G.; Duda, T.F.; Raa, L.A. te; Zon, T. van; Haley Jr., P.J., P. F. J.; Lermusiaux, P.F.J.; Leslie, W.G.; Mirabito, C.; Lam, F.P.A.; Newhall, A.E.; Lin, Y.T.; Lynch, J.F.

    2013-01-01

    During naval operations, sonar performance estimates often need to be computed in-situ with limited environmental information. This calls for the use of fast acoustic propagation models. Many naval operations are carried out in challenging and dynamic environments. This makes acoustic propagation

  17. Evolving dynamical regimes during secular cooling of terrestrial planets : insights and inferences from numerical models

    NARCIS (Netherlands)

    Thienen, Peter van

    2003-01-01

    Although plate tectonics is the present-day mode of geodynamics on Earth, it is not so on Mars and Venus, and probably also not during the early history of the Earth. In this thesis, the conditions under which plate tectonics may operate on terrestrial planets are investigated. Numerical model

  18. Evolving Approaches and Technologies to Enhance the Role of Ecological Modeling in Decision Making

    Science.gov (United States)

    Eric Gustafson; John Nestler; Louis Gross; Keith M. Reynolds; Daniel Yaussy; Thomas P. Maxwell; Virginia H. Dale

    2002-01-01

    Understanding the effects of management activities is difficult for natural resource managers and decision makers because ecological systems are highly complex and their behavior is difficult to predict. Furthermore, the empirical studies necessary to illuminate all management questions quickly become logistically complicated and cost prohibitive. Ecological models...

  19. Global Evolving Models of Photospheric Flux as Driven by Electric Fields

    Science.gov (United States)

    DeRosa, Marc L.; Cheung, Mark; Kazachenko, Maria D.; Fisher, George H.

    2017-08-01

    We present a novel method for modeling the global radial magnetic field that is based on the incorporation of time series of photospheric electric fields. The determination of the electric fields is the result of a recently developed method that uses as input various data products from SDO/HMI, namely vector magnetic fields and line-of-sight Doppler images. For locations on the sphere where electric field data are unavailable, we instead use electric fields that are consistent with measurements of the mean differential rotation, meridional flow, and flux dispersal profiles. By combining these electric fields, a full-Sun model of the photospheric radial magnetic field can be advanced forward in time via Faraday's Law.

  20. Evolving Transport Networks With Cellular Automata Models Inspired by Slime Mould.

    Science.gov (United States)

    Tsompanas, Michail-Antisthenis I; Sirakoulis, Georgios Ch; Adamatzky, Andrew I

    2015-09-01

    Man-made transport networks and their design are closely related to the shortest path problem and considered amongst the most debated problems of computational intelligence. Apart from using conventional or bio-inspired computer algorithms, many researchers tried to solve this kind of problem using biological computing substrates, gas-discharge solvers, prototypes of a mobile droplet, and hot ice computers. In this aspect, another example of biological computer is the plasmodium of acellular slime mould Physarum polycephalum (P. polycephalum), which is a large single cell visible by an unaided eye and has been proven as a reliable living substrate for implementing biological computing devices for computational geometry, graph-theoretical problems, and optimization and imitation of transport networks. Although P. polycephalum is easy to experiment with, computing devices built with the living slime mould are extremely slow; it takes slime mould days to execute a computation. Consequently, mapping key computing mechanisms of the slime mould onto silicon would allow us to produce efficient bio-inspired computing devices to tackle with hard to solve computational intelligence problems like the aforementioned. Toward this direction, a cellular automaton (CA)-based, Physarum-inspired, network designing model is proposed. This novel CA-based model is inspired by the propagating strategy, the formation of tubular networks, and the computing abilities of the plasmodium of P. polycephalum. The results delivered by the CA model demonstrate a good match with several previously published results of experimental laboratory studies on imitation of man-made transport networks with P. polycephalum. Consequently, the proposed CA model can be used as a virtual, easy-to-access, and biomimicking laboratory emulator that will economize large time periods needed for biological experiments while producing networks almost identical to the tubular networks of the real-slime mould.

  1. An updated conceptual model of Delta Smelt biology: Our evolving understanding of an estuarine fish

    Science.gov (United States)

    Baxter, Randy; Brown, Larry R.; Castillo, Gonzalo; Conrad, Louise; Culberson, Steven D.; Dekar, Matthew P.; Dekar, Melissa; Feyrer, Frederick; Hunt, Thaddeus; Jones, Kristopher; Kirsch, Joseph; Mueller-Solger, Anke; Nobriga, Matthew; Slater, Steven B.; Sommer, Ted; Souza, Kelly; Erickson, Gregg; Fong, Stephanie; Gehrts, Karen; Grimaldo, Lenny; Herbold, Bruce

    2015-01-01

    The main purpose of this report is to provide an up-to-date assessment and conceptual model of factors affecting Delta Smelt (Hypomesus transpacificus) throughout its primarily annual life cycle and to demonstrate how this conceptual model can be used for scientific and management purposes. The Delta Smelt is a small estuarine fish that only occurs in the San Francisco Estuary. Once abundant, it is now rare and has been protected under the federal and California Endangered Species Acts since 1993. The Delta Smelt listing was related to a step decline in the early 1980s; however, population abundance decreased even further with the onset of the “pelagic organism decline” (POD) around 2002. A substantial, albeit short-lived, increase in abundance of all life stages in 2011 showed that the Delta Smelt population can still rebound when conditions are favorable for spawning, growth, and survival. In this report, we update previous conceptual models for Delta Smelt to reflect new data and information since the release of the last synthesis report about the POD by the Interagency Ecological Program for the San Francisco Estuary (IEP) in 2010. Specific objectives include:

  2. An existential model of oral health from evolving views on health, function and disability.

    Science.gov (United States)

    MacEntee, Michael I

    2006-03-01

    This study explores the evolution of conceptual frameworks and models of health and disability to construct an explanatory model of oral health. The International Classification of Impairments, Disabilities, and Handicaps adopted by the WHO is based largely on social role theory and a utilitarian tradition portraying disablement as a negative and socially unacceptable consequence of impairment. It has been the major conceptual influence on the construction of psychometric tools for dentistry. However current views of chronic disease are refocused on the influence of coping strategies used by people to prevent or limit disability and handicap. Consequently, the WHO adopted the International Classification of Functioning, Disability and Health (ICF) as an alternative description of health and health-related states based on an existentialist view of the body, the person and society. In addition, an ethnographic exploration has identified three major domains of oral health--oral hygiene, comfort and general health--that dominate the opinions of people with oral impairments. Application of the framework and language of the ICF to the major domains of oral health provides the basis for a new biopsychosocial model of oral health, function and disablement.

  3. The fine line between normal and starburst galaxies

    Science.gov (United States)

    Lee, Nicholas; Sheth, Kartik; Scott, Kimberly S.; Toft, Sune; Magdis, Georgios E.; Damjanov, Ivana; Zahid, H. Jabran; Casey, Caitlin M.; Cortzen, Isabella; Gómez Guijarro, Carlos; Karim, Alexander; Leslie, Sarah K.; Schinnerer, Eva

    2017-10-01

    Recent literature suggests that there are two modes through which galaxies grow their stellar mass - a normal mode characterized by quasi-steady star formation, and a highly efficient starburst mode possibly triggered by stochastic events such as galaxy mergers. While these differences are established for extreme cases, the population of galaxies between these two regimes is poorly studied and it is not clear where the transition between these two modes of star formation occurs. We utilize the Atacama Large Millimeter/submillimeter Array observations of the CO J = 3-2 line luminosity in a sample of 20 infrared luminous galaxies that lie in the intermediate range between normal and starburst galaxies at z ∼ 0.25-0.65 in the Cosmic Evolution Survey field to examine their gas content and star formation efficiency. We compare these quantities to the galaxies' deviation from the well-studied 'main sequence' (MS) correlation between star formation rate and stellar mass and find that at log(SFR/SFRMS) ≲ 0.6, a galaxy's distance to the main sequence is primarily driven by increased gas content, and not a more efficient star formation process.

  4. Integrating Spanish language training across a Doctor of Physical Therapy curriculum: a case report of one program's evolving model.

    Science.gov (United States)

    Pechak, Celia; Diaz, Deborah; Dillon, Loretta

    2014-12-01

    As the Hispanic population continues to expand in the United States, health professionals increasingly may encounter people who speak Spanish and have limited English proficiency. Responding to these changes, various health profession educators have incorporated Spanish language training into their curricula. Of 12 doctor of physical therapy (DPT) programs identified as including elective or required Spanish courses, the program at The University of Texas at El Paso is the only one integrating required Spanish language training across the curriculum. The purpose of this case report is to describe the development, implementation, and preliminary outcomes of the evolving educational model at The University of Texas at El Paso. The University of Texas at El Paso is situated immediately across the border from Mexico. Responding to the large population with limited English proficiency in the community, faculty began to integrate required Spanish language training during a transition from a master-level to a DPT curriculum. The Spanish language curriculum pillar includes a Spanish medical terminology course, language learning opportunities threaded throughout the clinical courses, clinical education courses, and service-learning. Forty-five DPT students have completed the curriculum. Assessment methods were limited for early cohorts. Clinically relevant Spanish verbal proficiency was assessed with a practical examination in the Spanish course, a clinical instructor-rated instrument, and student feedback. Preliminary data suggested that the model is improving Spanish language proficiency. The model still is evolving. Spanish language learning opportunities in the curriculum are being expanded. Also, problems with the clinical outcome measure have been recognized. Better definition of intended outcomes and validation of a revised tool are needed. This report should promote opportunities for collaboration with others who are interested in linguistic competence. © 2014

  5. NOAA Ship Okeanos Explorer: Evolving Models Enabling Remote Science Participation via Telepresence

    Science.gov (United States)

    Elliott, K.; Potter, J.; Martinez, C.; Pinner, W.; Russell, C. W.; Verplanck, N.

    2014-12-01

    Since 2005 NOAA's Office of Ocean Exploration and Research (OER) and partners have tested and developed uses of telepresence to extend ocean exploration expeditions to shore-based scientists and students in real-time. Telepresence increases the potential pace and scope of ocean exploration by enabling experts to join an expedition from anywhere, providing unlimited access to intellectual capital, while simultaneously expanding the reach of ocean science expeditions to public audiences worldwide. "America's Ship for Ocean Exploration", NOAA Ship Okeanos Explorer, is the first and only federal vessel purpose-outfitted for conducting telepresence-enabled ocean exploration. As a platform for testing new technologies and methodologies, her primary operating paradigm focuses on using telepresence to enable the majority of expedition scientists to participate and guide explorations from shore in real-time. Between 2010-2014, NOAA and partners implemented different models to conduct telepresence-enabled ocean exploration on NOAA Ship Okeanos Explorer, all with the majority of the participating expedition scientists located on shore. These expeditions tested different scientist participation models, communication technologies, operating procedures, internet video streams, data distribution methods, and internet-based collaboration tools, and provided varying levels of real-time access to ongoing expeditions. Each expedition provided new insights into what makes remote science participation "work", and identified challenges that remain to be overcome. This presentation will provide an overview of the different methods and tools used by NOAA's Okeanos Explorer Program to enable remote science participation in expeditions over the last five years, highlighting successes, lessons learned, and challenges for the future.

  6. General synthesis of di-mu-oxo dimanganese complexes as functional models for the oxygen evolving complex of photosystem II.

    Science.gov (United States)

    Chen, Hongyu; Tagore, Ranitendranath; Das, Siddhartha; Incarvito, Christopher; Faller, J W; Crabtree, Robert H; Brudvig, Gary W

    2005-10-17

    A series of complexes with the formula [Mn(III/IV)2(mu-O)2(L)2(X)2]3+ have been prepared in situ from Mn(II)LCl2 precursors by a general preparative method (L = terpy, Cl-terpy, Br-terpy, Ph-terpy, tolyl-terpy, mesityl-terpy, t Bu3-terpy, EtO-terpy, py-phen, dpya, Me2N-terpy, or HO-terpy, and X = a labile ligand such as water, chloride, or sulfate). The parent complex, where L = terpy and X = water, is a functional model for the oxygen-evolving complex of photosystem II (Limburg, et al. J. Am. Chem. Soc. 2001, 123, 423-430). Crystals of Mn(II)(dpya)Cl2, Mn(II)(Ph-terpy)Cl2, Mn(II)(mesityl-terpy)Cl2, and an organic-soluble di-mu-oxo di-aqua dimanganese complex, [Mn(III/)(IV)2(mu-O)2(mesityl-terpy)2(OH2)2](NO3)3, were obtained and characterized by X-ray crystallography. Solutions of the in situ-formed di-mu-oxo dimanganese complexes were characterized by electrospray mass spectrometry, EPR spectroscopy, and UV-visible spectroscopy, and the rates of catalytic oxygen-evolving activity were assayed. The use of Mn(II)LCl2 precursors leads to higher product purity of the Mn dimers while achieving the 1:1 ligand to Mn stoichiometry appropriate for catalytic activity assay. These methods can be used to screen the catalytic activity of other di-mu-oxo dimanganese complexes generated by using a ligand library.

  7. Functional connectivity dynamically evolves on multiple time-scales over a static structural connectome: Models and mechanisms.

    Science.gov (United States)

    Cabral, Joana; Kringelbach, Morten L; Deco, Gustavo

    2017-03-23

    Over the last decade, we have observed a revolution in brain structural and functional Connectomics. On one hand, we have an ever-more detailed characterization of the brain's white matter structural connectome. On the other, we have a repertoire of consistent functional networks that form and dissipate over time during rest. Despite the evident spatial similarities between structural and functional connectivity, understanding how different time-evolving functional networks spontaneously emerge from a single structural network requires analyzing the problem from the perspective of complex network dynamics and dynamical system's theory. In that direction, bottom-up computational models are useful tools to test theoretical scenarios and depict the mechanisms at the genesis of resting-state activity. Here, we provide an overview of the different mechanistic scenarios proposed over the last decade via computational models. Importantly, we highlight the need of incorporating additional model constraints considering the properties observed at finer temporal scales with MEG and the dynamical properties of FC in order to refresh the list of candidate scenarios. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Evolving power grids with self-organized intermittent strain releases: An analogy with sandpile models and earthquakes

    Science.gov (United States)

    Po, Ho Fai; Yeung, Chi Ho; Zeng, An; Wong, K. Y. Michael

    2017-11-01

    The stability of powergrid is crucial since its disruption affects systems ranging from street lightings to hospital life-support systems. While short-term dynamics of single-event cascading failures have been extensively studied, less is understood on the long-term evolution and self-organization of powergrids. In this paper, we introduce a simple model of evolving powergrid and establish its connection with the sandpile model and earthquakes, i.e., self-organized systems with intermittent strain releases. Various aspects during its self-organization are examined, including blackout magnitudes, their interevent waiting time, the predictability of large blackouts, as well as the spatiotemporal rescaling of blackout data. We examined the self-organized strain releases on simulated networks as well as the IEEE 118-bus system, and we show that both simulated and empirical blackout waiting times can be rescaled in space and time similarly to those observed between earthquakes. Finally, we suggested proactive maintenance strategies to drive the powergrids away from self-organization to suppress large blackouts.

  9. Molecular gas during the post-starburst phase: low gas fractions in green-valley Seyfert post-starburst galaxies

    Science.gov (United States)

    Yesuf, Hassen M.; French, K. Decker; Faber, S. M.; Koo, David C.

    2017-08-01

    Post-starbursts (PSBs) are candidate for rapidly transitioning from starbursting to quiescent galaxies. We study the molecular gas evolution of PSBs at z ˜ 0.03-0.2. We undertook new CO (2-1) observations of 22 Seyfert PSB candidates using the Arizona Radio Observatory Submillimeter Telescope. This sample complements previous samples of PSBs by including green-valley PSBs with Seyfert-like emission, allowing us to analyse for the first time the molecular gas properties of 116 PSBs with a variety of AGN properties. The distribution of molecular gas to stellar mass fractions in PSBs is significantly different from normal star-forming galaxies in the CO Legacy Database (COLD) GASS survey. The combined samples of PSBs with Seyfert-like emission line ratios have a gas fraction distribution that is even more significantly different and is broader (˜0.03-0.3). Most of them have lower gas fractions than normal star-forming galaxies. We find a highly significant correlation between the WISE 12 and 4.6 μm flux ratios and molecular gas fractions in both PSBs and normal galaxies. We detect molecular gas in 27 per cent of our Seyfert PSBs. Taking into account the upper limits, the mean and the dispersion of the distribution of the gas fraction in our Seyfert PSB sample are much smaller (μ = 0.025, σ = 0.018) than previous samples of Seyfert PSBs or PSBs in general (μ ˜ 0.1-0.2, σ ˜ 0.1-0.2).

  10. INSTANTANEOUS STARBURST OF THE MASSIVE CLUSTERS WESTERLUND 1 AND NGC 3603 YC

    Energy Technology Data Exchange (ETDEWEB)

    Kudryavtseva, Natalia; Brandner, Wolfgang; Gennaro, Mario; Rochau, Boyke; Henning, Thomas [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, 69117 Heidelberg (Germany); Stolte, Andrea [Argelander Institut fuer Astronomie, Auf dem Huegel 71, 53121 Bonn (Germany); Andersen, Morten; Da Rio, Nicola [European Space Agency, Space Science Department, Keplerlaan 1, 2200 AG Noordwijk (Netherlands); Tognelli, Emanuele [Department of Physics, University of Pisa, Largo Bruno Pontecorvo 3, 56127 Pisa (Italy); Hogg, David [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, Room 424, New York, NY 10003 (United States); Clark, Simon [Department of Physics and Astronomy, The Open University, Milton Keynes MK7 6AA (United Kingdom); Waters, Rens [Sterrenkundig Instituut Anton Pannekoek, University of Amsterdam, Science Park 904, 1098 Amsterdam (Netherlands)

    2012-05-10

    We present a new method to determine the age spread of resolved stellar populations in a starburst cluster. The method relies on a two-step process. In the first step, kinematic members of the cluster are identified based on multi-epoch astrometric monitoring. In the second step, a Bayesian analysis is carried out, comparing the observed photometric sequence of cluster members with sets of theoretical isochrones. When applying this methodology to optical and near-infrared high angular resolution Hubble Space Telescope (HST) and adaptive optics observations of the {approx}5 Myr old starburst cluster Westerlund 1 and {approx}2 Myr old starburst cluster NGC 3603 YC, we derive upper limits for the age spreads of 0.4 and 0.1 Myr, respectively. The results strongly suggest that star formation in these starburst clusters happened almost instantaneously.

  11. High-redshift Post-starburst Galaxies from the Sloan Digital Sky Survey

    Science.gov (United States)

    Pattarakijwanich, Petchara

    Post-starburst galaxies are a rare class of galaxy that show the spectral signature of recent, but not ongoing, star-formation activity, and are thought to have their star formation suddenly quenched within the one billion years preceding the observations. In other words, these are galaxies in the transitional stage between blue, star-forming galaxies and red, quiescent galaxies, and therefore hold important information regarding our understanding of galaxy evolution. This class of objects can be used to study the mechanisms responsible for star-formation quenching, which is an important unsettled question in galaxy evolution. In this thesis, we study this class of galaxies through a number of different approaches. First of all, we systematically selected a large, statistical sample of post-starburst galaxies from the spectroscopic dataset of the Sloan Digital Sky Survey (SDSS). This sample contains 13219 objects in total, with redshifts ranging from local universe to z ˜ 1.3 and median redshift zmedian = 0.59. This is currently the largest sample of post-starburst galaxies available in the literature. Using this sample, we calculated the luminosity functions for a number of redshift bins. A rapid downsizing redshift evolution of the luminosity function is observed, whereby the number density of post-starburst galaxies at fixed luminosity is larger at higher redshift. From the luminosity functions, we calculated the amount of star-formation quenching accounted for in post-starburst galaxies, and compared to the amount required by the global decline of star-formation rate of the universe. We found that only a small fraction (˜ 0.2%) of all star-formation quenching in the universe goes through the post-starburst galaxy channel, at least for the luminous sources in our sample. We also searched the SDSS spectroscopic database the post-starburst quasars, which are an even more special class of objects that show both a post-starburst stellar population and AGN activity

  12. LOCALIZED STARBURSTS IN DWARF GALAXIES PRODUCED BY THE IMPACT OF LOW-METALLICITY COSMIC GAS CLOUDS

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez Almeida, J.; Muñoz-Tuñón, C.; Filho, M. E. [Instituto Astrofísica de Canarias, E-38200 La Laguna, Tenerife (Spain); Elmegreen, B. G. [IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY 10598 (United States); Elmegreen, D. M. [Department of Physics and Astronomy, Vassar College, Poughkeepsie, NY 12604 (United States); Pérez-Montero, E.; Vílchez, J. M. [Instituto de Astrofísica de Andalucía, CSIC, Granada (Spain); Amorín, R. [INAF-Osservatorio Astronomico di Roma, Monte Porzio Catone (Italy); Ascasibar, Y. [Universidad Autonoma de Madrid, Madrid (Spain); Papaderos, P., E-mail: jos@iac.es [Centro de Astrofísica da Universidade do Porto, Porto (Portugal)

    2015-09-10

    Models of galaxy formation predict that gas accretion from the cosmic web is a primary driver of star formation over cosmic history. Except in very dense environments where galaxy mergers are also important, model galaxies feed from cold streams of gas from the web that penetrate their dark matter halos. Although these predictions are unambiguous, the observational support has been indirect so far. Here, we report spectroscopic evidence for this process in extremely metal-poor galaxies (XMPs) of the local universe, taking the form of localized starbursts associated with gas having low metallicity. Detailed abundance analyses based on Gran Telescopio Canarias optical spectra of 10 XMPs show that the galaxy hosts have metallicities around 60% solar, on average, while the large star-forming regions that dominate their integrated light have low metallicities of some 6% solar. Because gas mixes azimuthally in a rotation timescale (a few hundred Myr), the observed metallicity inhomogeneities are only possible if the metal-poor gas fell onto the disk recently. We analyze several possibilities for the origin of the metal-poor gas, favoring the metal-poor gas infall predicted by numerical models. If this interpretation is correct, XMPs trace the cosmic web gas in their surroundings, making them probes to examine its properties.

  13. Interaction of methanol with the oxygen-evolving complex: atomistic models, channel identification, species dependence, and mechanistic implications.

    Science.gov (United States)

    Retegan, Marius; Pantazis, Dimitrios A

    2016-10-01

    Methanol has long being used as a substrate analogue to probe access pathways and investigate water delivery at the oxygen-evolving complex (OEC) of photosystem-II. In this contribution we study the interaction of methanol with the OEC by assembling available spectroscopic data into a quantum mechanical treatment that takes into account the local channel architecture of the active site. The effect on the magnetic energy levels of the Mn4Ca cluster in the S2 state of the catalytic cycle can be explained equally well by two models that involve either methanol binding to the calcium ion of the cluster, or a second-sphere interaction in the vicinity of the "dangler" Mn4 ion. However, consideration of the latest 13C hyperfine interaction data shows that only one model is fully consistent with experiment. In contrast to previous hypotheses, methanol is not a direct ligand to the OEC, but is situated at the end-point of a water channel associated with the O4 bridge. Its effect on magnetic properties of plant PS-II results from disruption of hydrogen bonding between O4 and proximal channel water molecules, thus enhancing superexchange (antiferromagnetic coupling) between the Mn3 and Mn4 ions. The same interaction mode applies to the dark-stable S1 state and possibly to all other states of the complex. Comparison of protein sequences from cyanobacteria and plants reveals a channel-altering substitution (D1-Asn87 versus D1-Ala87) in the proximity of the methanol binding pocket, explaining the species-dependence of the methanol effect. The water channel established as the methanol access pathway is the same that delivers ammonia to the Mn4 ion, supporting the notion that this is the only directly solvent-accessible manganese site of the OEC. The results support the pivot mechanism for water binding at a component of the S3 state and would be consistent with partial inhibition of water delivery by methanol. Mechanistic implications for enzymatic regulation and catalytic

  14. Evolvable synthetic neural system

    Science.gov (United States)

    Curtis, Steven A. (Inventor)

    2009-01-01

    An evolvable synthetic neural system includes an evolvable neural interface operably coupled to at least one neural basis function. Each neural basis function includes an evolvable neural interface operably coupled to a heuristic neural system to perform high-level functions and an autonomic neural system to perform low-level functions. In some embodiments, the evolvable synthetic neural system is operably coupled to one or more evolvable synthetic neural systems in a hierarchy.

  15. The carrier of the "30" mu m emission feature in evolved stars - A simple model using magnesium sulfide

    NARCIS (Netherlands)

    Hony, S; Waters, LBFM; Tielens, AGGM

    We present 2-45 mum spectra of a large sample of carbon-rich evolved stars in order to study the "30" mum feature. We find the "30" mum feature in a wide range of sources: low mass loss carbon stars, extreme carbon-stars, post-AGB objects and planetary nebulae. We extract the profiles from the

  16. A PACS maturity model: a systematic meta-analytic review on maturation and evolvability of PACS in the hospital enterprise.

    NARCIS (Netherlands)

    Wetering, R. van de; Batenburg, R.

    2009-01-01

    INTRODUCTION: With PACS and medical imaging technology maturing, the importance of organizational maturity and effective deployment of PACS in the hospital enterprise are becoming significant. OBJECTIVE: The objective of this paper is twofold. Firstly, PACS literature on maturity and evolvability in

  17. Lots of Small Stars Born in Starburst Region

    Science.gov (United States)

    1999-10-01

    Decisive Study of NGC 3603 with the VLT and ISAAC An international group of astronomers [1] has used the ESO Very Large Telescope (VLT) at Paranal (Chile) to perform unique observations of an interstellar nebula in which stars are currently being born. Thanks to the excellent imaging properties of the first of the four 8.2-m VLT Unit Telescopes, ANTU, they were able to demonstrate, for the first time, the presence of large numbers of small and relatively light, new-born stars in NGC 3603, a well-known "starburst" region in the Milky Way Galaxy . Until now, it has only been possible to observe brighter and much heavier stars in such nebulae. The new observations show that stars of all masses are being born together in the same starburst event, a fundamental result for our understanding of the very complex process of star formation. Background of the project The present research programme was granted observing time with VLT ANTU in April 1999. Its general aim is to investigate collective, massive star formation, in particular the coalescence of high- and low-mass stars in the violent environments of starburst regions . These are areas in which the processes that lead to the birth of new stars are particularly active just now. Several fundamental questions arise in this context. A very basic one is whether low-mass stars form at all in such environments. And if so, do they form together with the most massive stars in a starburst event or do they form at different times, before or after or perhaps on different timescales? Are low-mass stars born with any "preferred" mass that may possibly give further clues to the ongoing processes? All of this is most important in order to understand the detailed mechanisms of star formation. Most current theoretical scenarios explain how single stars form in an isolated, contracting gas cloud, but most stars in the Universe did not form in that simple way. Once some massive stars have formed in some place and start to shine, they

  18. Welcome to the Twilight Zone: The Mid-infrared Properties of Post-starburst Galaxies

    Science.gov (United States)

    Alatalo, Katherine; Bitsakis, Theodoros; Lanz, Lauranne; Lacy, Mark; Brown, Michael J. I.; French, K. Decker; Ciesla, Laure; Appleton, Philip N.; Beaton, Rachael L.; Cales, Sabrina L.; Crossett, Jacob; Falcón-Barroso, Jesús; Kelson, Daniel D.; Kewley, Lisa J.; Kriek, Mariska; Medling, Anne M.; Mulchaey, John S.; Nyland, Kristina; Rich, Jeffrey A.; Urry, C. Meg

    2017-07-01

    We investigate the optical and Wide-field Survey Explorer (WISE) colors of “E+A” identified post-starburst galaxies, including a deep analysis of 190 post-starbursts detected in the 2 μm All Sky Survey Extended Source Catalog. The post-starburst galaxies appear in both the optical green valley and the WISE Infrared Transition Zone. Furthermore, we find that post-starbursts occupy a distinct region of [3.4]-[4.6] versus [4.6]-[12] WISE colors, enabling the identification of this class of transitioning galaxies through the use of broadband photometric criteria alone. We have investigated possible causes for the WISE colors of post-starbursts by constructing a composite spectral energy distribution (SED), finding that the mid-infrared (4-12 μm) properties of post-starbursts are consistent with either 11.3 μm polycyclic aromatic hydrocarbon emission, or thermally pulsating asymptotic giant branch (TP-AGB) and post-AGB stars. The composite SED of extended post-starburst galaxies with 22 μm emission detected with signal-to-noise ratio ≥slant 3 requires a hot dust component to produce their observed rising mid-infrared SED between 12 and 22 μm. The composite SED of WISE 22 μm non-detections (S/N images, is also flat, requiring a hot dust component. The most likely source of the mid-infrared emission of these E+A galaxies is a buried active galactic nucleus (AGN). The inferred upper limits to the Eddington ratios of post-starbursts are 10-2-10-4, with an average of 10-3. This suggests that AGNs are not radiatively dominant in these systems. This could mean that including selections capable of identifying AGNs as part of a search for transitioning and post-starburst galaxies would create a more complete census of the transition pathways taken as a galaxy quenches its star formation.

  19. Lyman Break Analogs: Constraints on the Formation of Extreme Starbursts at Low and High Redshift

    Science.gov (United States)

    Goncalves, Thiago S.; Overzier, Roderik; Basu-Zych, Antara; Martin, D. Christopher

    2011-01-01

    Lyman Break Analogs (LBAs), characterized by high far-UV luminosities and surface brightnesses as detected by GALEX, are intensely star-forming galaxies in the low-redshift universe (z approximately equal to 0.2), with star formation rates reaching up to 50 times that of the Milky Way. These objects present metallicities, morphologies and other physical properties similar to higher redshift Lyman Break Galaxies (LBGs), motivating the detailed study of LBAs as local laboratories of this high-redshift galaxy population. We present results from our recent integral-field spectroscopy survey of LBAs with Keck/OSIRIS, which shows that these galaxies have the same nebular gas kinematic properties as high-redshift LBGs. We argue that such kinematic studies alone are not an appropriate diagnostic to rule out merger events as the trigger for the observed starburst. Comparison between the kinematic analysis and morphological indices from HST imaging illustrates the difficulties of properly identifying (minor or major) merger events, with no clear correlation between the results using either of the two methods. Artificial redshifting of our data indicates that this problem becomes even worse at high redshift due to surface brightness dimming and resolution loss. Whether mergers could generate the observed kinematic properties is strongly dependent on gas fractions in these galaxies. We present preliminary results of a CARMA survey for LBAs and discuss the implications of the inferred molecular gas masses for formation models.

  20. A continuum mechanics approach to modeling and simulating engineering materials undergoing phase transformation using the evolving micro-structural model of inelasticity

    Science.gov (United States)

    Adedoyin, Adetokunbo Adelana

    Heat treatment for the purpose of material strengthening is accompanied by residual stresses and distortion. During these processing steps, steel alloys experience a phase change that in turn modify their overall mechanical response. To properly account for the cumulative composite behavior, the mechanical response, transformation kinetics and subsequent interaction of each phase have to be properly accounted for. Of interest to material designers and fabricators is modeling and simulating the evolutionary process a part undergoes for the sake of capturing the observable residual stress states and geometric distortion accumulated after processing. In an attempt to capture the aforementioned physical phenomena, this investigation is premised upon a consistent thermodynamic framework. Following this, the single phase Evolving Microstructural Model of Inelasticity state variable model is extended to accommodate the occurrence of multiphases, affirming that the interaction between coexisting phases is through an interfacial stress. Since the efficacy of a multiphase model is dependent on its ability to capture the behavior of constituents phases and their subsequent interaction, we introduce a physically based self-consistent strain partitioning algorithm. With synthesis of the aforementioned ideas, the additional transformation induced plasticity is numerically accounted for by modifying each phase's flowrule to accommodate an interfacial stress. In addition, for simulating the cohabitation of two phases, the mechanical multiphase model equations is coupled with a previously developed non-diffusional phase transformation kinetics model. A qualitative assessment of the material response based on a Taylor, Sachs and self-consistent polycrystalline approximation is carried out. Further analysis of the multiphase model and its interaction with transformation kinetics is evaluated.

  1. The effect of central starbursts on the interstellar medium of dwarf galaxies

    Science.gov (United States)

    De Young, David S.; Heckman, Timothy M.

    1994-01-01

    Major starburst events can last tens of millions of years, and in the process they can deposit significant amounts of energy into the surrounding interstellar medium. This energy from supernova and stellar winds imparts enough momentum to the interstellar medium (ISM) that portions of the ISM can become unbound and leave the parent galaxy, taking the metal-enriched stellar debris along. In dwarf galaxies, starbursts can produce enough total energy to unbind most or all of the ambient ISM. Whether this actually occurs is a strong function of the ellipticity of the ISM distribution, with flat disks and spheres being the limiting cases. We calculate whether 'blow out' along the symmetry axis of 'blow away' of the entire ISM occurs during a central starburst in dwarf galaxies as a function of galactic mass, starburst energy, ISM density, and ISM ellipticity. The calculations cover a range of 10(exp 7) to 10(exp 9) solar mass for dwarf galaxies and include 'normal' galaxies of 10(exp 11) solar mass as well. No massive dark matter halos are assumed to be present. We find that for physically reasonable values of total ISM mass and starburst energy a blow out along the symmetry axis occurs in the majority of cases, though a significant fraction of small dwarf galaxies can lose most of their ISM. As no dark matter halos or clumpy ISM distributions are included, it is apparent that the ISM in most dwarf galaxies may be generally resistant to significant disruption by a central starburst event. The effects of this range of behavi or on the metallicities that would be observed in these galaxies is discussed.

  2. Natural selection promotes antigenic evolvability.

    Science.gov (United States)

    Graves, Christopher J; Ros, Vera I D; Stevenson, Brian; Sniegowski, Paul D; Brisson, Dustin

    2013-01-01

    The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide an experimentally tractable system to test whether natural selection has favored mechanisms that increase evolvability. Many antigenic variation systems consist of paralogous unexpressed 'cassettes' that recombine into an expression site to rapidly alter the expressed protein. Importantly, the magnitude of antigenic change is a function of the genetic diversity among the unexpressed cassettes. Thus, evidence that selection favors among-cassette diversity is direct evidence that natural selection promotes antigenic evolvability. We used the Lyme disease bacterium, Borrelia burgdorferi, as a model to test the prediction that natural selection favors amino acid diversity among unexpressed vls cassettes and thereby promotes evolvability in a primary surface antigen, VlsE. The hypothesis that diversity among vls cassettes is favored by natural selection was supported in each B. burgdorferi strain analyzed using both classical (dN/dS ratios) and Bayesian population genetic analyses of genetic sequence data. This hypothesis was also supported by the conservation of highly mutable tandem-repeat structures across B. burgdorferi strains despite a near complete absence of sequence conservation. Diversification among vls cassettes due to natural selection and mutable repeat structures promotes long-term antigenic evolvability of VlsE. These findings provide a direct demonstration that molecular mechanisms that enhance evolvability of surface antigens are an evolutionary adaptation. The molecular evolutionary processes identified here can serve as a model for the evolution of antigenic evolvability in many pathogens which utilize similar strategies to establish chronic infections.

  3. Natural selection promotes antigenic evolvability.

    Directory of Open Access Journals (Sweden)

    Christopher J Graves

    Full Text Available The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide an experimentally tractable system to test whether natural selection has favored mechanisms that increase evolvability. Many antigenic variation systems consist of paralogous unexpressed 'cassettes' that recombine into an expression site to rapidly alter the expressed protein. Importantly, the magnitude of antigenic change is a function of the genetic diversity among the unexpressed cassettes. Thus, evidence that selection favors among-cassette diversity is direct evidence that natural selection promotes antigenic evolvability. We used the Lyme disease bacterium, Borrelia burgdorferi, as a model to test the prediction that natural selection favors amino acid diversity among unexpressed vls cassettes and thereby promotes evolvability in a primary surface antigen, VlsE. The hypothesis that diversity among vls cassettes is favored by natural selection was supported in each B. burgdorferi strain analyzed using both classical (dN/dS ratios and Bayesian population genetic analyses of genetic sequence data. This hypothesis was also supported by the conservation of highly mutable tandem-repeat structures across B. burgdorferi strains despite a near complete absence of sequence conservation. Diversification among vls cassettes due to natural selection and mutable repeat structures promotes long-term antigenic evolvability of VlsE. These findings provide a direct demonstration that molecular mechanisms that enhance evolvability of surface antigens are an evolutionary adaptation. The molecular evolutionary processes identified here can serve as a model for the evolution of antigenic evolvability in many pathogens which utilize similar strategies to establish

  4. From nearby low-mass protostars to high redshift starbursts: protostellar outflows tracing the IMF

    Science.gov (United States)

    Kristensen, Lars E.; Bergin, Edwin

    2015-08-01

    Embedded low-mass protostars are notoriously difficult to observe even in the nearest Galactic high-mass clusters where they outnumber the high-mass protostars by orders of magnitude. Thus, without a good tracer of the low-mass population, we do not have a good handle on the shape of the initial (core) mass function, leaving little hope for extrapolating to extragalactic regions where we will never have neither the sensitivity nor the resolution to directly observe this population. A good tracer of the low-mass population is needed.One such physical tracer is outflows. Outflow emission is directly proportional to envelope mass, and outflows are predominantly active during the deeply embedded phases of star formation. What is required for this method to work is species and transitions tracing outflows uniquely such that any signal is not diluted by the surrounding cloud, such as certain methanol transitions, water, high-J CO (J > 10).I will present a statistical model of a forming high-mass cluster. The model includes what we currently know about Galactic high-mass clusters and incorporates outflow emission from low-mass protostars. The latter component is obtained from observations of tens of nearby embedded low-mass protostellar outflows in the above-mentioned tracers. The model is benchmarked against ALMA and Herschel-HIFI observations of Galactic clusters proving the concept, and preliminary extrapolations to the extragalactic regime are presented. With this new probe, and traditional probes of the distant star formation which predominantly trace high mass stars, we will be able to explore the IMF in starburst galaxies from low to high redshift.

  5. Massive post-starburst galaxies at z > 1 are compact proto-spheroids

    Science.gov (United States)

    Almaini, Omar; Wild, Vivienne; Maltby, David T.; Hartley, William G.; Simpson, Chris; Hatch, Nina A.; McLure, Ross J.; Dunlop, James S.; Rowlands, Kate

    2017-12-01

    We investigate the relationship between the quenching of star formation and the structural transformation of massive galaxies, using a large sample of photometrically selected post-starburst galaxies in the UKIDSS Ultra-Deep Survey field. We find that post-starburst galaxies at high redshift (z > 1) show high Sérsic indices, significantly higher than those of active star-forming galaxies, but with a distribution that is indistinguishable from the old quiescent population. We conclude that the morphological transformation occurs before (or during) the quenching of star formation. Recently quenched galaxies are also the most compact; we find evidence that massive post-starburst galaxies (M* > 1010.5 M⊙) at high redshift (z > 1) are on average smaller than comparable quiescent galaxies at the same epoch. Our findings are consistent with a scenario in which massive passive galaxies are formed from three distinct phases: (1) gas-rich dissipative collapse to very high densities, forming the proto-spheroid, (2) rapid quenching of star formation to create the 'red nugget' with post-starburst features and (3) a gradual growth in size as the population ages, perhaps as a result of minor mergers.

  6. Evidence for an Interaction in the Nearest Starbursting Dwarf Irregular Galaxy IC 10

    NARCIS (Netherlands)

    Nidever, David L.; Ashley, Trisha; Slater, Colin T.; Ott, Juergen; Johnson, Megan; Bell, Eric F.; Stanimirovic, Snezana; Putman, Mary; Majewski, Steven R.; Simpson, Caroline E.; Juette, Eva; Oosterloo, Tom A.; Burton, W. Butler

    2013-01-01

    Using deep 21 cm Hi data from the Green Bank Telescope we have detected an greater than or similar to 18.3 kpc long gaseous extension associated with the starbursting dwarf galaxy IC 10. The newly found feature stretches 1 degrees.3 to the northwest and has a large radial velocity gradient reaching

  7. ALMA observations of cool dust in a low-metallicity starburst, SBS 0335−052

    National Research Council Canada - National Science Library

    Hunt, L. K; Testi, L; Casasola, V; García-Burillo, S; Combes, F; Nikutta, R; Caselli, P; Henkel, C; Maiolino, R; Menten, K. M; Sauvage, M; Weiss, A

    2014-01-01

    We present Atacama Large Millimeter/submillimeter Array (ALMA) Cycle 0 Band 7 observations of an extremely metal-poor dwarf starburst galaxy in the Local Universe, SBS 0335−052 (12 + log (O/H) ~ 7.2...

  8. The low-metallicity starburst NGC346: massive-star population and feedback

    Science.gov (United States)

    Oskinova, Lida

    2017-08-01

    The Small Magellanic Cloud (SMC) is ideal to study young, massive stars at low metallicity. The compact cluster NGC346 contains about half of all O-type stars in the entire SMC. The massive-star population of this cluster powers N66, the brightest and largest HII region in the SMC. We propose to use HST-STIS to slice NGC346 with 20 long-slit exposures, in order to obtain the UV spectra of most of the massive early-type stars of this cluster. Archival data of 13 exposures that cover already a minor part of this cluster will be included in our analyses. Our aim is to quantitatively analyze virtually the whole massive-star population of NGC346. We have already secured the optical spectra of all massive stars in the field with the integral-field spectrograph MUSE at the ESO-VLT. However, for the determination of the stellar-wind parameters, i.e. the mass-loss rates and the wind velocities, ultraviolet spectra are indispensable. Our advanced Potsdam Wolf-Rayet (PoWR) code will be used for modeling the stellar and wind spectra in the course of the analysis. Finally, we will obtain:(a) the fundamental stellar and wind parameters of all stars brighter than spectral type B2V in the field, which, e,g,, will constrain the initial mass function in this young low-metallicity starburst;(b) mass-loss rates of many more OB-type stars at SMC metallicity than hitherto known, allowing to better constrain their metallicity dependence;(c) the integrated feedback by ionizing radiation and stellar winds of the whole massive-star population of NGC346, which will be used as input to model the ecology of the giant HII region N66.These HST UV data will be of high legacy value.

  9. A case study of an extremely luminous, highly spatially extended starburst only 1.7Gyr after the Big Bang

    Science.gov (United States)

    Farrah, Duncan

    2017-08-01

    Luminous starbursts, systems with SFRs exceeding 1000Msun yr-1, are predicted to be extremely rare at z>3. However, recent observations find such systems at rates of tens to hundreds above predictions. This discrepancy is extremely difficult to explain. Case studies of such luminous starbursts are thus of profound importance to understand how star formation is triggered and quenched at z > 3, and help reconcile models with observations. Our group has been intensively studying the quasar SDSS J160705.16, at z = 3.65 (or 1.7Gyr after the Big Bang). This quasar is an excellent case study of luminous star formation at z > 3, and how AGN activity may affect such star formation. SDSS J160705.16 harbors both a broad-line, luminous quasar and an extremely high star formation rate, with an AGN luminosity of 10^47 ergs s-1 and an SFR of 2000 Msol yr-1. Sub-mm interferometry has further revealed that the star formation is highly spatially extended on scales up to 40kpc. Furthermore, VLA observations show an emerging 4kpc radio jet.We here propose WFC3 imaging with the following goals: (1) to set precise constraints on any lensing magnification, (2) to determine the morphology and color structure of the extended star formation, (3) to compare the optical morphology of the star formation to that seen in the sub-mm data, and (4) to search for evidence that SDSS J160705.16 resides in a protocluster.

  10. OBSERVATIONAL CONSTRAINTS ON THE MOLECULAR GAS CONTENT IN NEARBY STARBURST DWARF GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    McQuinn, Kristen B. W.; Skillman, Evan D. [Department of Astronomy, School of Physics and Astronomy, 116 Church Street, S.E., University of Minnesota, Minneapolis, MN 55455 (United States); Dalcanton, Julianne J.; Weisz, Daniel R.; Williams, Benjamin F. [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Dolphin, Andrew E. [Raytheon Company, 1151 E. Hermans Road, Tucson, AZ 85756 (United States); Cannon, John M. [Department of Physics and Astronomy, Macalester College, 1600 Grand Avenue, Saint Paul, MN 55105 (United States); Holtzman, Jon, E-mail: kmcquinn@astro.umn.edu [Department of Astronomy, New Mexico State University, Box 30001, Department 4500, 1320 Frenger Street, Las Cruces, NM 88003 (United States)

    2012-06-01

    Using star formation histories derived from optically resolved stellar populations in 19 nearby starburst dwarf galaxies observed with the Hubble Space Telescope, we measure the stellar mass surface densities of stars newly formed in the bursts. By assuming a star formation efficiency (SFE), we then calculate the inferred gas surface densities present at the onset of the starbursts. Assuming an SFE of 1%, as is often assumed in normal star-forming galaxies, and assuming that the gas was purely atomic, translates to very high H I surface densities ({approx}10{sup 2}-10{sup 3} M{sub Sun} pc{sup -2}), which are much higher than have been observed in dwarf galaxies. This implies either higher values of SFE in these dwarf starburst galaxies or the presence of significant amounts of H{sub 2} in dwarfs (or both). Raising the assumed SFEs to 10% or greater (in line with observations of more massive starbursts associated with merging galaxies), still results in H I surface densities higher than observed in 10 galaxies. Thus, these observations appear to require that a significant fraction of the gas in these dwarf starbursts galaxies was in the molecular form at the onset of the bursts. Our results imply molecular gas column densities in the range 10{sup 19}-10{sup 21} cm{sup -2} for the sample. In the galaxies where CO observations have been made, these densities correspond to values of the CO-H{sub 2} conversion factor (X{sub CO}) in the range >(3-80) Multiplication-Sign 10{sup 20} cm{sup -2} (K km s{sup -1}){sup -1}, or up to 40 Multiplication-Sign greater than Galactic X{sub CO} values.

  11. Large turbulent reservoirs of cold molecular gas around high-redshift starburst galaxies

    Science.gov (United States)

    Falgarone, E.; Zwaan, M. A.; Godard, B.; Bergin, E.; Ivison, R. J.; Andreani, P. M.; Bournaud, F.; Bussmann, R. S.; Elbaz, D.; Omont, A.; Oteo, I.; Walter, F.

    2017-08-01

    Starburst galaxies at the peak of cosmic star formation are among the most extreme star-forming engines in the Universe, producing stars over about 100 million years (ref. 2). The star-formation rates of these galaxies, which exceed 100 solar masses per year, require large reservoirs of cold molecular gas to be delivered to their cores, despite strong feedback from stars or active galactic nuclei. Consequently, starburst galaxies are ideal for studying the interplay between this feedback and the growth of a galaxy. The methylidyne cation, CH+, is a most useful molecule for such studies because it cannot form in cold gas without suprathermal energy input, so its presence indicates dissipation of mechanical energy or strong ultraviolet irradiation. Here we report the detection of CH+ (J = 1-0) emission and absorption lines in the spectra of six lensed starburst galaxies at redshifts near 2.5. This line has such a high critical density for excitation that it is emitted only in very dense gas, and is absorbed in low-density gas. We find that the CH+ emission lines, which are broader than 1,000 kilometres per second, originate in dense shock waves powered by hot galactic winds. The CH+ absorption lines reveal highly turbulent reservoirs of cool (about 100 kelvin), low-density gas, extending far (more than 10 kiloparsecs) outside the starburst galaxies (which have radii of less than 1 kiloparsec). We show that the galactic winds sustain turbulence in the 10-kiloparsec-scale environments of the galaxies, processing these environments into multiphase, gravitationally bound reservoirs. However, the mass outflow rates are found to be insufficient to balance the star-formation rates. Another mass input is therefore required for these reservoirs, which could be provided by ongoing mergers or cold-stream accretion. Our results suggest that galactic feedback, coupled jointly to turbulence and gravity, extends the starburst phase of a galaxy instead of quenching it.

  12. EXTENDED HCN AND HCO{sup +} EMISSION IN THE STARBURST GALAXY M82

    Energy Technology Data Exchange (ETDEWEB)

    Salas, P.; Galaz, G. [Instituto de Astrofísica, Facultad de Física, Pontificia Universidad Católica de Chile, Av. Vicua Mackenna 4860, 782-0436 Macul, Santiago (Chile); Salter, D.; Herrera-Camus, R.; Bolatto, A. D. [Department of Astronomy and Laboratory for Millimeter-Wave Astronomy, University of Maryland, College Park, MD 20742 (United States); Kepley, A. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903-2475 (United States)

    2014-12-20

    We mapped 3 mm continuum and line emission from the starburst galaxy M82 using the Combined Array for Research in Millimeter-wave Astronomy. We targeted the HCN, HCO{sup +}, HNC, CS, and HC{sub 3}N lines, but here we focus on the HCN and HCO{sup +} emission. The map covers a field of 1.'2 with an ≈5'' resolution. The HCN and HCO{sup +} observations are short spacings corrected. The molecular gas in M82 had been previously found to be distributed in a molecular disk, coincident with the central starburst, and a galactic scale outflow which originates in the central starburst. With the new short spacings-corrected maps we derive some of the properties of the dense molecular gas in the base of the outflow. From the HCN and HCO{sup +} J = (1-0) line emission, and under the assumptions of the gas being optically thin and in local thermodynamic equilibrium, we place lower limits on the amount of dense molecular gas in the base of the outflow. The lower limits are 7 × 10{sup 6} M {sub ☉} and 21 × 10{sup 6} M {sub ☉}, or ≳ 2% of the total molecular mass in the outflow. The kinematics and spatial distribution of the dense gas outside the central starburst suggests that it is being expelled through chimneys. Assuming a constant outflow velocity, the derived outflow rate of dense molecular gas is ≥0.3 M {sub ☉} yr{sup –1}, which would lower the starburst lifetime by ≥5%. The energy required to expel this mass of dense gas is (1-10) × 10{sup 52} erg.

  13. A modeling and control framework for operating large-scale electric power systems under present and newly evolving competitive industry structures

    Directory of Open Access Journals (Sweden)

    Marija D. Ilić

    1995-01-01

    Full Text Available This paper introduces a systematic, structure-based modeling framework for analysis and control of electric power systems for processes evolving over the mid-term and long-term time horizons. Much simpler models than the detailed dynamics specifically for control design at different hierarchical levels are obtained by applying both temporal and spatial separation. These simple models, or the aggregate models, represent the net effect of interactions among interconnected regions on specific hierarchical levels. They are exact, since no assumptions on weak interconnections among the subsystems are made. Moreover they are easily understood in terms of power flows among the regions. The approach is essential for improving present performance of the system. It is also potentially useful in a competitive utility environment in which it is critical to study the interplay between technical and economic processes.

  14. Distention of the Immature Left Ventricle Triggers Development of Endocardial Fibroelastosis: An Animal Model of Endocardial Fibroelastosis Introducing Morphopathological Features of Evolving Fetal Hypoplastic Left Heart Syndrome

    Directory of Open Access Journals (Sweden)

    Shogo Shimada

    2015-01-01

    Full Text Available Background. Endocardial fibroelastosis (EFE, characterized by a diffuse endocardial thickening through collagen and elastin fibers, develops in the human fetal heart restricting growth of the left ventricle (LV. Recent advances in fetal imaging indicate that EFE development is directly associated with a distended, poorly contractile LV in evolving hypoplastic left heart syndrome (HLHS. In this study, we developed an animal model of EFE by introducing this human fetal LV morphopathology to an immature rat heart. Methods and Results. A neonatal donor heart, in which aortic regurgitation (AR was created, was heterotopically transplanted into a recipient adult rat. AR successfully induced the LV morphology of evolving HLHS in the transplanted donor hearts, which resulted in the development of significant EFE covering the entire LV cavity within two weeks postoperatively. In contrast, posttransplants with a competent aortic valve displayed unloaded LVs with a trace of EFE. Conclusions. We could show that distention of the immature LV in combination with stagnant flow triggers EFE development in this animal model. This model would serve as a robust tool to develop therapeutic strategies to treat EFE while providing insight into its pathogenesis.

  15. Final Report for Award #0006731. Modeling, Patterning and Evolving Syntrophic Communities that Link Fermentation to Metal Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Christopher J. [Harvard Univ., Cambridge, MA (United States)

    2015-07-17

    This project has developed and combined mathematical models, multi-species consortia, and spatially structured environments as an approach for studying metabolic exchange in communities like the ones between fermenters and metal reducers. We have developed novel, broadly-applicable tools for following community dynamics, come to a better understanding of both sugar and lactate-utilization in S. oneidensis, the interactions between carbon and mineral availability, and have a methodology for cell printing to match with spatiotemporal models of consortia metabolism.

  16. Asymmetric evolving random networks

    Science.gov (United States)

    Coulomb, S.; Bauer, M.

    2003-10-01

    We generalize the Poissonian evolving random graph model of M. Bauer and D. Bernard (2003), to deal with arbitrary degree distributions. The motivation comes from biological networks, which are well-known to exhibit non Poissonian degree distributions. A node is added at each time step and is connected to the rest of the graph by oriented edges emerging from older nodes. This leads to a statistical asymmetry between incoming and outgoing edges. The law for the number of new edges at each time step is fixed but arbitrary. Thermodynamical behavior is expected when this law has a large time limit. Although (by construction) the incoming degree distributions depend on this law, this is not the case for most qualitative features concerning the size distribution of connected components, as long as the law has a finite variance. As the variance grows above 1/4, the average being < 1/2, a giant component emerges, which connects a finite fraction of the vertices. Below this threshold, the distribution of component sizes decreases algebraically with a continuously varying exponent. The transition is of infinite order, in sharp contrast with the case of static graphs. The local-in-time profiles for the components of finite size allow to give a refined description of the system.

  17. Functional imaging studies of emotion regulation: A synthetic review and evolving model of the cognitive control of emotion

    Science.gov (United States)

    Ochsner, Kevin N.; Silvers, Jennifer A.; Buhle, Jason T.

    2014-01-01

    This paper reviews and synthesizes functional imaging research that over the past decade has begun to offer new insights into the brain mechanisms underlying emotion regulation. Towards that end, the first section of the paper outlines a model of the processes and neural systems involved in emotion generation and regulation. The second section surveys recent research supporting and elaborating the model, focusing primarily on studies of the most commonly investigated strategy, which is known as reappraisal. At its core, the model specifies how prefrontal and cingulate control systems modulate activity in perceptual, semantic and affect systems as a function of one's regulatory goals, tactics, and the nature of the stimuli and emotions being regulated. This section also shows how the model can be generalized to understand the brain mechanisms underlying other emotion regulation strategies as well as a range of other allied phenomena. The third and last section considers directions for future research, including how basic models of emotion regulation can be translated to understand changes in emotion across the lifespan and in clinical disorders. PMID:23025352

  18. Evolving MCDM Applications Using Hybrid Expert-Based ISM and DEMATEL Models: An Example of Sustainable Ecotourism

    Directory of Open Access Journals (Sweden)

    Huan-Ming Chuang

    2013-01-01

    Full Text Available Ecological degradation is an escalating global threat. Increasingly, people are expressing awareness and priority for concerns about environmental problems surrounding them. Environmental protection issues are highlighted. An appropriate information technology tool, the growing popular social network system (virtual community, VC, facilitates public education and engagement with applications for existent problems effectively. Particularly, the exploration of related involvement behavior of VC member engagement is an interesting topic. Nevertheless, member engagement processes comprise interrelated sub-processes that reflect an interactive experience within VCs as well as the value co-creation model. To address the top-focused ecotourism VCs, this study presents an application of a hybrid expert-based ISM model and DEMATEL model based on multi-criteria decision making tools to investigate the complex multidimensional and dynamic nature of member engagement. Our research findings provide insightful managerial implications and suggest that the viral marketing of ecotourism protection is concerned with practitioners and academicians alike.

  19. Evolving MCDM applications using hybrid expert-based ISM and DEMATEL models: an example of sustainable ecotourism.

    Science.gov (United States)

    Chuang, Huan-Ming; Lin, Chien-Ku; Chen, Da-Ren; Chen, You-Shyang

    2013-01-01

    Ecological degradation is an escalating global threat. Increasingly, people are expressing awareness and priority for concerns about environmental problems surrounding them. Environmental protection issues are highlighted. An appropriate information technology tool, the growing popular social network system (virtual community, VC), facilitates public education and engagement with applications for existent problems effectively. Particularly, the exploration of related involvement behavior of VC member engagement is an interesting topic. Nevertheless, member engagement processes comprise interrelated sub-processes that reflect an interactive experience within VCs as well as the value co-creation model. To address the top-focused ecotourism VCs, this study presents an application of a hybrid expert-based ISM model and DEMATEL model based on multi-criteria decision making tools to investigate the complex multidimensional and dynamic nature of member engagement. Our research findings provide insightful managerial implications and suggest that the viral marketing of ecotourism protection is concerned with practitioners and academicians alike.

  20. Evolving digital ecological networks.

    Directory of Open Access Journals (Sweden)

    Miguel A Fortuna

    Full Text Available "It is hard to realize that the living world as we know it is just one among many possibilities" [1]. Evolving digital ecological networks are webs of interacting, self-replicating, and evolving computer programs (i.e., digital organisms that experience the same major ecological interactions as biological organisms (e.g., competition, predation, parasitism, and mutualism. Despite being computational, these programs evolve quickly in an open-ended way, and starting from only one or two ancestral organisms, the formation of ecological networks can be observed in real-time by tracking interactions between the constantly evolving organism phenotypes. These phenotypes may be defined by combinations of logical computations (hereafter tasks that digital organisms perform and by expressed behaviors that have evolved. The types and outcomes of interactions between phenotypes are determined by task overlap for logic-defined phenotypes and by responses to encounters in the case of behavioral phenotypes. Biologists use these evolving networks to study active and fundamental topics within evolutionary ecology (e.g., the extent to which the architecture of multispecies networks shape coevolutionary outcomes, and the processes involved.

  1. A depth-averaged debris-flow model that includes the effects of evolving dilatancy. I. physical basis

    Science.gov (United States)

    Iverson, Richard M.; George, David L.

    2014-01-01

    To simulate debris-flow behaviour from initiation to deposition, we derive a depth-averaged, two-phase model that combines concepts of critical-state soil mechanics, grain-flow mechanics and fluid mechanics. The model's balance equations describe coupled evolution of the solid volume fraction, m, basal pore-fluid pressure, flow thickness and two components of flow velocity. Basal friction is evaluated using a generalized Coulomb rule, and fluid motion is evaluated in a frame of reference that translates with the velocity of the granular phase, vs. Source terms in each of the depth-averaged balance equations account for the influence of the granular dilation rate, defined as the depth integral of ∇⋅vs. Calculation of the dilation rate involves the effects of an elastic compressibility and an inelastic dilatancy angle proportional to m−meq, where meq is the value of m in equilibrium with the ambient stress state and flow rate. Normalization of the model equations shows that predicted debris-flow behaviour depends principally on the initial value of m−meq and on the ratio of two fundamental timescales. One of these timescales governs downslope debris-flow motion, and the other governs pore-pressure relaxation that modifies Coulomb friction and regulates evolution of m. A companion paper presents a suite of model predictions and tests.

  2. Chronos and KAIROS: MOSFIRE observations of post-starburst galaxies in z ˜ 1 clusters and groups

    Science.gov (United States)

    Lemaux, B. C.; Tomczak, A. R.; Lubin, L. M.; Wu, P.-F.; Gal, R. R.; Rumbaugh, N.; Kocevski, D. D.; Squires, G. K.

    2017-11-01

    We present an exploration of ˜500 spectroscopically confirmed galaxies in and around two large-scale structures (LSSs) at z ˜ 1 drawn from the Observations of Redshift Evolution in Large Scale Environments survey, an ongoing, wide-field photometric and spectroscopic campaign targeting a large ensemble of LSSs at 0.6 frame optical) methods even after the removal of the relatively large fraction of dusty starburst galaxies selected through traditional methods. While the traditional post-starburst fraction increased with increasing global density, the MOSFIRE-selected post-starburst fraction was found to be constant across field, group, and cluster environments. However, this fraction computed relative to the number of star-forming galaxies was observed to elevate in the cluster environment. Post-starbursts selected with MOSFIRE exhibited moderately strong [O II] emission originating from activity other than star formation. Such galaxies, termed K+A with ImposteR [O II]-derived Star formation (KAIROS) galaxies, were found to be younger than and likely undergoing feedback absent or diminished in their optically selected counterparts. A comparison between the environments of the two types of post-starbursts suggested a picture in which the evolution of a post-starburst galaxy is considerably different in cluster environments than in the more rarefied environments of a group or the field.

  3. The Battlefield Health and Trauma Research Institute Scientific Ethics Committee: An Evolving Model for Fostering a Culture of Integrity

    Science.gov (United States)

    2012-01-01

    grants and contracts.8 The ORI defines research misconduct as ‘‘fabrication, falsification, or plagiarism in proposing, performing, or reviewing research...fabrication, falsification, or plagiarism (FFP) is only 1% to 2%, based on self-reporting.10,11 However, approx- imately 33% of scientists admitted...provide investigators training and guidance? THE ACADEMIC MODEL Just as regulations governing the ethical use of human and animal research subjects grew

  4. The Evolving role of Tier2s in ATLAS with the new Computing and Data Distribution Model

    CERN Document Server

    Gonzalez de la Hoz, S; The ATLAS collaboration

    2012-01-01

    Originally the ATLAS computing model assumed that the Tier2s of each of the 10 clouds should keep on disk collectively at least one copy of all "active" AOD and DPD datasets. Evolution of ATLAS computing and data models requires changes in ATLAS Tier2s policy for the data replication, dynamic data caching and remote data access. Tier2 operations take place completely asynchronously with respect to data taking. Tier2s do simulation and user analysis. Large-scale reprocessing jobs on real data are at first taking place mostly at Tier1s but will progressively move to Tier2s as well. The availability of disk space at Tier2s is extremely important in the ATLAS computing model as it allows more data to be readily accessible for analysis jobs to all users, independently of their geographical location. The Tier2s disk space has been reserved for real, simulated, calibration and alignment, group, and user data. A buffer disk space is needed for input and output data for simulations jobs. Tier2s are going to be used mo...

  5. The evolving role of Tier2s in ATLAS with the new Computing and Data Distribution model

    CERN Document Server

    Gonzalez de la Hoz, S

    2012-01-01

    Originally the ATLAS computing model assumed that the Tier2s of each of the 10 clouds should keep on disk collectively at least one copy of all "active" AOD and DPD datasets. Evolution of ATLAS computing and data models requires changes in ATLAS Tier2s policy for the data replication, dynamic data caching and remote data access. Tier2 operations take place completely asynchronously with respect to data taking. Tier2s do simulation and user analysis. Large-scale reprocessing jobs on real data are at first taking place mostly at Tier1s but will progressively move to Tier2s as well. The availability of disk space at Tier2s is extremely important in the ATLAS computing model as it allows more data to be readily accessible for analysis jobs to all users, independently of their geographical location. The Tier2s disk space has been reserved for real, simulated, calibration and alignment, group, and user data. A buffer disk space is needed for input and output data for simulations jobs. Tier2s are going to be used mo...

  6. MATRIX-VBS (v1.0): implementing an evolving organic aerosol volatility in an aerosol microphysics model

    Science.gov (United States)

    Gao, Chloe Y.; Tsigaridis, Kostas; Bauer, Susanne E.

    2017-02-01

    The gas-particle partitioning and chemical aging of semi-volatile organic aerosol are presented in a newly developed box model scheme, where its effect on the growth, composition, and mixing state of particles is examined. The volatility-basis set (VBS) framework is implemented into the aerosol microphysical scheme MATRIX (Multiconfiguration Aerosol TRacker of mIXing state), which resolves mass and number aerosol concentrations and in multiple mixing-state classes. The new scheme, MATRIX-VBS, has the potential to significantly advance the representation of organic aerosols in Earth system models by improving upon the conventional representation as non-volatile particulate organic matter, often also with an assumed fixed size distribution. We present results from idealized cases representing Beijing, Mexico City, a Finnish forest, and a southeastern US forest, and investigate the evolution of mass concentrations and volatility distributions for organic species across the gas and particle phases, as well as assessing their mixing state among aerosol populations. Emitted semi-volatile primary organic aerosols evaporate almost completely in the intermediate-volatility range, while they remain in the particle phase in the low-volatility range. Their volatility distribution at any point in time depends on the applied emission factors, oxidation by OH radicals, and temperature. We also compare against parallel simulations with the original scheme, which represented only the particulate and non-volatile component of the organic aerosol, examining how differently the condensed-phase organic matter is distributed across the mixing states in the model. The results demonstrate the importance of representing organic aerosol as a semi-volatile aerosol, and explicitly calculating the partitioning of organic species between the gas and particulate phases.

  7. MATRIX-VBS (v1.0): Implementing an Evolving Organic Aerosol Volatility in an Aerosol Microphysics Model

    Science.gov (United States)

    Gao, Chloe Y.; Tsigaridis, Kostas; Bauer, Susanne E.

    2017-01-01

    The gas-particle partitioning and chemical aging of semi-volatile organic aerosol are presented in a newly developed box model scheme, where its effect on the growth, composition, and mixing state of particles is examined. The volatility-basis set (VBS) framework is implemented into the aerosol microphysical scheme MATRIX (Multiconfiguration Aerosol TRacker of mIXing state), which resolves mass and number aerosol concentrations and in multiple mixing-state classes. The new scheme, MATRIX-VBS, has the potential to significantly advance the representation of organic aerosols in Earth system models by improving upon the conventional representation as non-volatile particulate organic matter, often also with an assumed fixed size distribution. We present results from idealized cases representing Beijing, Mexico City, a Finnish forest, and a southeastern US forest, and investigate the evolution of mass concentrations and volatility distributions for organic species across the gas and particle phases, as well as assessing their mixing state among aerosol populations. Emitted semi-volatile primary organic aerosols evaporate almost completely in the intermediate-volatility range, while they remain in the particle phase in the low-volatility range. Their volatility distribution at any point in time depends on the applied emission factors, oxidation by OH radicals, and temperature. We also compare against parallel simulations with the original scheme, which represented only the particulate and non-volatile component of the organic aerosol, examining how differently the condensed-phase organic matter is distributed across the mixing states in the model. The results demonstrate the importance of representing organic aerosol as a semi-volatile aerosol, and explicitly calculating the partitioning of organic species between the gas and particulate phases.

  8. Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

    Science.gov (United States)

    Trushina, Eugenia; Nemutlu, Emirhan; Zhang, Song; Christensen, Trace; Camp, Jon; Mesa, Janny; Siddiqui, Ammar; Tamura, Yasushi; Sesaki, Hiromi; Wengenack, Thomas M.; Dzeja, Petras P.; Poduslo, Joseph F.

    2012-01-01

    Background The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve monitoring and predicting of AD progression. Mitochondrial dysfunction has been suggested to underlie AD pathophysiology, however, no comprehensive study exists that evaluates the effect of different familial AD (FAD) mutations on mitochondrial function, dynamics, and brain energetics. Methods and Findings We characterized early mitochondrial dysfunction and metabolomic signatures of energetic stress in three commonly used transgenic mouse models of FAD. Assessment of mitochondrial motility, distribution, dynamics, morphology, and metabolomic profiling revealed the specific effect of each FAD mutation on the development of mitochondrial stress and dysfunction. Inhibition of mitochondrial trafficking was characteristic for embryonic neurons from mice expressing mutant human presenilin 1, PS1(M146L) and the double mutation of human amyloid precursor protein APP(Tg2576) and PS1(M146L) contributing to the increased susceptibility of neurons to excitotoxic cell death. Significant changes in mitochondrial morphology were detected in APP and APP/PS1 mice. All three FAD models demonstrated a loss of the integrity of synaptic mitochondria and energy production. Metabolomic profiling revealed mutation-specific changes in the levels of metabolites reflecting altered energy metabolism and mitochondrial dysfunction in brains of FAD mice. Metabolic biomarkers adequately reflected gender differences similar to that reported for AD patients and correlated well with the biomarkers currently used for diagnosis in humans. Conclusions Mutation-specific alterations in mitochondrial dynamics, morphology and function in FAD mice occurred prior to the onset of memory and neurological phenotype and before the formation of amyloid deposits. Metabolomic signatures of mitochondrial stress and altered energy metabolism indicated

  9. THE PANCHROMATIC STARBURST IRREGULAR DWARF SURVEY (STARBIRDS): OBSERVATIONS AND DATA ARCHIVE

    Energy Technology Data Exchange (ETDEWEB)

    McQuinn, Kristen B. W.; Mitchell, Noah P.; Skillman, Evan D., E-mail: kmcquinn@astro.umn.edu [Institute for Astrophysics, University of Minnesota, 116 Church Street, S.E., Minneapolis, MN 55455 (United States)

    2015-06-22

    Understanding star formation in resolved low mass systems requires the integration of information obtained from observations at different wavelengths. We have combined new and archival multi-wavelength observations on a set of 20 nearby starburst and post-starburst dwarf galaxies to create a data archive of calibrated, homogeneously reduced images. Named the panchromatic “STARBurst IRregular Dwarf Survey” archive, the data are publicly accessible through the Mikulski Archive for Space Telescopes. This first release of the archive includes images from the Galaxy Evolution Explorer Telescope (GALEX), the Hubble Space Telescope (HST), and the Spitzer Space Telescope (Spitzer) Multiband Imaging Photometer instrument. The data sets include flux calibrated, background subtracted images, that are registered to the same world coordinate system. Additionally, a set of images are available that are all cropped to match the HST field of view. The GALEX and Spitzer images are available with foreground and background contamination masked. Larger GALEX images extending to 4 times the optical extent of the galaxies are also available. Finally, HST images convolved with a 5″ point spread function and rebinned to the larger pixel scale of the GALEX and Spitzer 24 μm images are provided. Future additions are planned that will include data at other wavelengths such as Spitzer IRAC, ground-based Hα, Chandra X-ray, and Green Bank Telescope H i imaging.

  10. The evolving market structures of gambling: case studies modelling the socioeconomic assignment of gaming machines in Melbourne and Sydney, Australia.

    Science.gov (United States)

    Marshall, David C; Baker, Robert G V

    2002-01-01

    The expansion of gambling industries worldwide is intertwined with the growing government dependence on gambling revenue for fiscal assignments. In Australia, electronic gaming machines (EGMs) have dominated recent gambling industry growth. As EGMs have proliferated, growing recognition has emerged that EGM distribution closely reflects levels of socioeconomic disadvantage. More machines are located in less advantaged regions. This paper analyses time-series socioeconomic distributions of EGMs in Melbourne, Australia, an immature EGM market, and then compares the findings with the mature market in Sydney. Similar findings in both cities suggest that market assignment of EGMs transcends differences in historical and legislative environments. This indicates that similar underlying structures are evident in both markets. Modelling the spatial structures of gambling markets provides an opportunity to identify regions most at risk of gambling related problems. Subsequently, policies can be formulated which ensure fiscal revenue from gambling can be better targeted towards regions likely to be most afflicted by excessive gambling-related problems.

  11. Genomic, RNAseq, and Molecular Modeling Evidence Suggests That the Major Allergen Domain in Insects Evolved from a Homodimeric Origin

    Science.gov (United States)

    Randall, Thomas A.; Perera, Lalith; London, Robert E.; Mueller, Geoffrey A.

    2013-01-01

    The major allergen domain (MA) is widely distributed in insects. The crystal structure of a single Bla g 1 MA revealed a novel protein fold in which the fundamental structure was a duplex of two subsequences (monomers), which had diverged over time. This suggested that the evolutionary origin of the MA structure may have been a homodimer of this smaller subsequence. Using publicly available genomic data, the distribution of the basic unit of this class of proteins was determined to better understand its evolutionary history. The duplication and divergence is examined at three distinct levels of resolution: 1) within the orders Diptera and Hymenoptera, 2) within one genus Drosophila, and 3) within one species Aedes aegypti. Within the family Culicidae, we have found two separate occurrences of monomers as independent genes. The organization of the gene family in A. aegypti shows a common evolutionary origin for its monomer and several closely related MAs. Molecular modeling of the A. aegypti monomer with the unique Bla g 1 fold confirms the distant evolutionary relationship and supports the feasibility of homodimer formation from a single monomer. RNAseq data for A. aegypti confirms that the monomer is expressed in the mosquito similar to other A. aegypti MAs after a blood meal. Together, these data support the contention that the detected monomer shares similar functional characteristics to related MAs in other insects. An extensive search for this domain outside of Insecta confirms that the MAs are restricted to insects. PMID:24253356

  12. SU-B-BRF-01: Professional Council Symposium: The Evolving US Healthcare Delivery Model, How Will the Medical Physics Profession Be Impacted and How Should We Respond?

    Energy Technology Data Exchange (ETDEWEB)

    Halvorsen, P [Lahey Clinic, Burlington, MA (United States); Shine, K [Austin, TX (United States); White, G [Colorado Associates in Medical Phys, Colorado Springs, CO (United States)

    2014-06-15

    The United States' healthcare delivery model is undergoing significant change. Insurance and reimbursement models are rapidly evolving, federal allocations are shifting from specialty services to preventive and generalpractice services, and Accountable Care Organizations are gaining in prominence. One area of focus is on the perceived over-utilization of expensive services such as advanced imaging and, in some cases, radiation therapy. Reimbursement incentives are increasingly aimed at quality metrics, leading to an increased interest in the core concepts of High Reliability Organizations. With the shift in federal resources away from specialty services and the increasing prominence of Accountable Care Organizations, we will likely be challenged to re-assess our traditional model for delivering medical physics services. Medical physicists have a unique combination of education and training in physics principles, radiation physics applications in medicine, human anatomy, as well as safety analysis and quality control methods. An effective medical physicist recognizes that to advance the institution's mission, the medical physicist must join other professional leaders within the institution to provide clear direction and perspective for the entire team. To do that, we must first recognize the macro changes in our healthcare delivery system and candidly assess how the medical physics practice model can evolve in a prudent way to support the institution's objectives while maintaining the traditionally high level of quality and safety. This year's Professional Council Symposium will explore the many facets of the changing healthcare system and its potential impact on medical physics. Dr. Shine will provide an overview of the developing healthcare delivery and reimbursement models, with a focus on how the physician community has adapted to the changing objectives. Mr. White will describe recent changes in the reimbursement patterns for both imaging

  13. The escape of Lyman photons from a young starburst: the case of Haro11†

    Science.gov (United States)

    Hayes, Matthew; Östlin, Göran; Atek, Hakim; Kunth, Daniel; Mas-Hesse, J. Miguel; Leitherer, Claus; Jiménez-Bailón, Elena; Adamo, Angela

    2007-12-01

    Lyman α (Lyα) is one of the dominant tools used to probe the star-forming galaxy population at high redshift (z). However, astrophysical interpretations of data drawn from Lyα alone hinge on the Lyα escape fraction which, due to the complex radiative transport, may vary greatly. Here, we map the Lyα emission from the local luminous blue compact galaxy Haro11, a known emitter of Lyα and the only known candidate for low-z Lyman continuum emission. To aid in the interpretation, we perform a detailed ultraviolet and optical multiwavelength analysis and model the stellar population, dust distribution, ionizing photon budget, and star-cluster population. We use archival X-ray observations to further constrain properties of the starburst and estimate the neutral hydrogen column density. The Lyα morphology is found to be largely symmetric around a single young star-forming knot and is strongly decoupled from other wavelengths. From general surface photometry, only very slight correlation is found between Lyα and Hα, E(B - V), and the age of the stellar population. Only around the central Lyα bright cluster do we find the Lyα/Hα ratio at values predicted by the recombination theory. The total Lyα escape fraction is found to be just 3 per cent. We compute that ~90 per cent of the Lyα photons that escape do so after undergoing multiple resonance scattering events, masking their point of origin. This leads to a largely symmetric distribution and, by increasing the distance that photons must travel to escape, decreases the escape probability significantly. While dust must ultimately be responsible for the destruction of Lyα, it plays a little role in governing the observed morphology, which is regulated more by interstellar medium kinematics and geometry. We find tentative evidence for local Lyα equivalent width in the immediate vicinity of star clusters being a function of cluster age, consistent with hydrodynamic studies. We estimate the intrinsic production

  14. Measurably evolving populations

    DEFF Research Database (Denmark)

    Drummond, Alexei James; Pybus, Oliver George; Rambaut, Andrew

    2003-01-01

    processes through time. Populations for which such studies are possible � measurably evolving populations (MEPs) � are characterized by sufficiently long or numerous sampled sequences and a fast mutation rate relative to the available range of sequence sampling times. The impact of sequences sampled through...... understanding of evolutionary processes in diverse organisms, from viruses to vertebrates....

  15. AGN and Starbursts in Dusty Galaxy Mergers: Insights from the Great Observatories All-sky LIRG Survey

    Science.gov (United States)

    Mazzarella, Joseph M.

    2014-07-01

    The Great Observatories All-sky LIRG Survey (GOALS) is combining imaging and spectroscopic data from the Herschel, Spitzer, Hubble, GALEX, Chandra, and XMM-Newton space telescopes augmented with extensive ground-based observations in a multiwavelength study of approximately 180 Luminous Infrared Galaxies (LIRGs) and 20 Ultraluminous Infrared Galaxies (ULIRGs) that comprise a statistically complete subset of the 60μm-selected IRAS Revised Bright Galaxy Sample. The objects span the full range of galaxy environments (giant isolated spirals, wide and close pairs, minor and major mergers, merger remnants) and nuclear activity types (Seyfert 1, Seyfert 2, LINER, starburst/HII), with proportions that depend strongly on the total infrared luminosity. I will review the science motivations and present highlights of recent results selected from over 25 peer-reviewed journal articles published recently by the GOALS Team. Statistical investigations include detection of high-ionization Fe K emission indicative of deeply embedded AGN, comparison of UV and far-IR properties, investigations of the fraction of extended emission as a function of wavelength derived from mid-IR spectroscopy, mid-IR spectral diagnostics and spectral energy distributions revealing the relative contributions of AGN and starbursts to powering the bolometric luminosity, and quantitative structure analyses that delineate the evolution of stellar bars and nuclear stellar cusps during the merger process. Multiwavelength dissections of individual systems have unveiled large populations of young star clusters and heavily obscured AGN in early-stage (II Zw 96), intermediate-stage (Mrk 266, Mrk 273), and late-stage (NGC 2623, IC 883) mergers. A recently published study that matches numerical simulations to the observed morphology and gas kinematics in mergers has placed four systems on a timeline spanning 175-260 million years after their first passages, and modeling of additional (U)LIRGs is underway. A very

  16. Electron spin-lattice relaxation of the S0 state of the oxygen-evolving complex in photosystem II and of dinuclear manganese model complexes.

    Science.gov (United States)

    Kulik, L V; Lubitz, W; Messinger, J

    2005-07-05

    The temperature dependence of the electron spin-lattice relaxation time T1 was measured for the S0 state of the oxygen-evolving complex (OEC) in photosystem II and for two dinuclear manganese model complexes by pulse EPR using the inversion-recovery method. For [Mn(III)Mn(IV)(mu-O)2 bipy4]ClO4, the Raman relaxation process dominates at temperatures below 50 K. In contrast, Orbach type relaxation was found for [Mn(II)Mn(III)(mu-OH)(mu-piv)2(Me3 tacn)2](ClO4)2 between 4.3 and 9 K. For the latter complex, an energy separation of 24.7-28.0 cm(-1) between the ground and the first excited electronic state was determined. In the S0 state of photosystem II, the T1 relaxation times were measured in the range of 4.3-6.5 K. A comparison with the relaxation data (rate and pre-exponential factor) of the two model complexes and of the S2 state of photosystem II indicates that the Orbach relaxation process is dominant for the S0 state and that its first excited state lies 21.7 +/- 0.4 cm(-1) above its ground state. The results are discussed with respect to the structure of the OEC in photosystem II.

  17. Fractionation and current time trends of PCB congeners: evolvement of distributions 1950–2010 studied using a global atmosphere-ocean general circulation model

    Directory of Open Access Journals (Sweden)

    G. Lammel

    2012-08-01

    Full Text Available PCBs are ubiquitous environmental pollutants expected to decline in abiotic environmental media in response to decreasing primary emissions since the 1970s. A coupled atmosphere-ocean general circulation model with embedded dynamic sub-models for atmospheric aerosols and the marine biogeochemistry and air-surface exchange processes with soils, vegetation and the cryosphere is used to study the transport and fate of four PCB congeners covering a range of 3–7 chlorine atoms.

    The change of the geographic distribution of the PCB mixture reflects the sources and sinks' evolvement over time. Globally, secondary emissions (re-volatilisation from surfaces are on the long term increasingly gaining importance over primary emissions. Secondary emissions are most important for the congeners with 5–6 chlorine atoms. Correspondingly, the levels of these congeners are predicted to decrease slowest. Changes in congener mixture composition (fractionation are characterized both geographically and temporally. In high latitudes enrichment of the lighter, less persistent congeners and more delayed decreasing levels in response to decreasing emissions are found. The delivery of the contaminants to high latitudes is predicted to be more efficient than previously suggested. The results suggest furthermore that the effectiveness of emission control measures may significantly vary among substances. The trends of decline of organic contaminant levels in the abiotic environmental media do not only vary with latitude (slow in high latitudes, but do also show longitudinal gradients.

  18. EVOLVE 2014 International Conference

    CERN Document Server

    Tantar, Emilia; Sun, Jian-Qiao; Zhang, Wei; Ding, Qian; Schütze, Oliver; Emmerich, Michael; Legrand, Pierrick; Moral, Pierre; Coello, Carlos

    2014-01-01

    This volume encloses research articles that were presented at the EVOLVE 2014 International Conference in Beijing, China, July 1–4, 2014.The book gathers contributions that emerged from the conference tracks, ranging from probability to set oriented numerics and evolutionary computation; all complemented by the bridging purpose of the conference, e.g. Complex Networks and Landscape Analysis, or by the more application oriented perspective. The novelty of the volume, when considering the EVOLVE series, comes from targeting also the practitioner’s view. This is supported by the Machine Learning Applied to Networks and Practical Aspects of Evolutionary Algorithms tracks, providing surveys on new application areas, as in the networking area and useful insights in the development of evolutionary techniques, from a practitioner’s perspective. Complementary to these directions, the conference tracks supporting the volume, follow on the individual advancements of the subareas constituting the scope of the confe...

  19. Evolvable Neural Software System

    Science.gov (United States)

    Curtis, Steven A.

    2009-01-01

    The Evolvable Neural Software System (ENSS) is composed of sets of Neural Basis Functions (NBFs), which can be totally autonomously created and removed according to the changing needs and requirements of the software system. The resulting structure is both hierarchical and self-similar in that a given set of NBFs may have a ruler NBF, which in turn communicates with other sets of NBFs. These sets of NBFs may function as nodes to a ruler node, which are also NBF constructs. In this manner, the synthetic neural system can exhibit the complexity, three-dimensional connectivity, and adaptability of biological neural systems. An added advantage of ENSS over a natural neural system is its ability to modify its core genetic code in response to environmental changes as reflected in needs and requirements. The neural system is fully adaptive and evolvable and is trainable before release. It continues to rewire itself while on the job. The NBF is a unique, bilevel intelligence neural system composed of a higher-level heuristic neural system (HNS) and a lower-level, autonomic neural system (ANS). Taken together, the HNS and the ANS give each NBF the complete capabilities of a biological neural system to match sensory inputs to actions. Another feature of the NBF is the Evolvable Neural Interface (ENI), which links the HNS and ANS. The ENI solves the interface problem between these two systems by actively adapting and evolving from a primitive initial state (a Neural Thread) to a complicated, operational ENI and successfully adapting to a training sequence of sensory input. This simulates the adaptation of a biological neural system in a developmental phase. Within the greater multi-NBF and multi-node ENSS, self-similar ENI s provide the basis for inter-NBF and inter-node connectivity.

  20. Ranking in evolving complex networks

    Science.gov (United States)

    Liao, Hao; Mariani, Manuel Sebastian; Medo, Matúš; Zhang, Yi-Cheng; Zhou, Ming-Yang

    2017-05-01

    Complex networks have emerged as a simple yet powerful framework to represent and analyze a wide range of complex systems. The problem of ranking the nodes and the edges in complex networks is critical for a broad range of real-world problems because it affects how we access online information and products, how success and talent are evaluated in human activities, and how scarce resources are allocated by companies and policymakers, among others. This calls for a deep understanding of how existing ranking algorithms perform, and which are their possible biases that may impair their effectiveness. Many popular ranking algorithms (such as Google's PageRank) are static in nature and, as a consequence, they exhibit important shortcomings when applied to real networks that rapidly evolve in time. At the same time, recent advances in the understanding and modeling of evolving networks have enabled the development of a wide and diverse range of ranking algorithms that take the temporal dimension into account. The aim of this review is to survey the existing ranking algorithms, both static and time-aware, and their applications to evolving networks. We emphasize both the impact of network evolution on well-established static algorithms and the benefits from including the temporal dimension for tasks such as prediction of network traffic, prediction of future links, and identification of significant nodes.

  1. The first high resolution image of coronal gas in a starbursting cool core cluster

    Science.gov (United States)

    Johnson, Sean

    2017-08-01

    Galaxy clusters represent a unique laboratory for directly observing gas cooling and feedback due to their high masses and correspondingly high gas densities and temperatures. Cooling of X-ray gas observed in 1/3 of clusters, known as cool-core clusters, should fuel star formation at prodigious rates, but such high levels of star formation are rarely observed. Feedback from active galactic nuclei (AGN) is a leading explanation for the lack of star formation in most cool clusters, and AGN power is sufficient to offset gas cooling on average. Nevertheless, some cool core clusters exhibit massive starbursts indicating that our understanding of cooling and feedback is incomplete. Observations of 10^5 K coronal gas in cool core clusters through OVI emission offers a sensitive means of testing our understanding of cooling and feedback because OVI emission is a dominant coolant and sensitive tracer of shocked gas. Recently, Hayes et al. 2016 demonstrated that synthetic narrow-band imaging of OVI emission is possible through subtraction of long-pass filters with the ACS+SBC for targets at z=0.23-0.29. Here, we propose to use this exciting new technique to directly image coronal OVI emitting gas at high resolution in Abell 1835, a prototypical starbursting cool-core cluster at z=0.252. Abell 1835 hosts a strong cooling core, massive starburst, radio AGN, and at z=0.252, it offers a unique opportunity to directly image OVI at hi-res in the UV with ACS+SBC. With just 15 orbits of ACS+SBC imaging, the proposed observations will complete the existing rich multi-wavelength dataset available for Abell 1835 to provide new insights into cooling and feedback in clusters.

  2. Analyzing Evolving Social Network 2 (EVOLVE2)

    Science.gov (United States)

    2015-04-01

    social media. We have demonstrated recently that information spread cannot be modeled as an epidemic diffusion. Instead, cognitive constraints, such as...respond to any one stimulus. Cognitive constraints the nature of social interactions and therefore, how central nodes are identified. Now a node’s...link prediction task and their properties. network nodes edges missing density social networks dolphins 62 159 16 0.084 email 1133 5452 545 0.0085

  3. New Deep HST/ACS Photometry of NGC 1569: Constraining the Evolution of the Strongest Starburst in the Nearby Universe

    Science.gov (United States)

    Grocholski, Aaron J.; van der Marel, R. P.; Aloisi, A.; Mack, J.

    2010-01-01

    Massive starbursts drive the evolution of galaxies at high redshift, but they can only be studied in detail in the nearby Universe where they are much rarer. The dwarf irregular galaxy NGC 1569 has always been considered the closest example of a true starburst, with exceptionally high sustained star formation (SF) over the last Gyr. This recent SF has been extensively constrainted by HST studies that reached to near the presumed magnitude of the tip of the red giant branch (TRGB). These studies could not address the onset of the most ancient SF or the triggering mechanism of the current starburst. Here we present new deep HST ACS/WFC photometry of the resolved stars in NGC 1569 that goes some 4 mag deeper than any previous HST observations. These data allowed us to unequivocally detect and measure the TRGB for the first time and show that NGC 1569 is considerably farther away than previously believed. At ˜3 Mpc it is actually a member of the IC 342 group of galaxies, instead of being a starburst in isolation. In addition to the TRGB, our increased photometric depth also gives access to the fainter red clump and horizontal branch features in the I vs V-I color-magnitude diagram (CMD) of NGC 1569, allowing us to constrain for the first time even the most ancient SFH of this extreme starburst through the use of synthetic CMDs. The area sampled by our ACS/WFC observations is some 25 times larger than in previous HST studies, allowing us to characterize the spatial variations of the SFH, from the central star forming regions of NGC 1569 out into the older and more sparsely populated "halo". The results reveal the evolutionary status of this extreme starburst over cosmic time.

  4. Regolith Evolved Gas Analyzer

    Science.gov (United States)

    Hoffman, John H.; Hedgecock, Jud; Nienaber, Terry; Cooper, Bonnie; Allen, Carlton; Ming, Doug

    2000-01-01

    The Regolith Evolved Gas Analyzer (REGA) is a high-temperature furnace and mass spectrometer instrument for determining the mineralogical composition and reactivity of soil samples. REGA provides key mineralogical and reactivity data that is needed to understand the soil chemistry of an asteroid, which then aids in determining in-situ which materials should be selected for return to earth. REGA is capable of conducting a number of direct soil measurements that are unique to this instrument. These experimental measurements include: (1) Mass spectrum analysis of evolved gases from soil samples as they are heated from ambient temperature to 900 C; and (2) Identification of liberated chemicals, e.g., water, oxygen, sulfur, chlorine, and fluorine. REGA would be placed on the surface of a near earth asteroid. It is an autonomous instrument that is controlled from earth but does the analysis of regolith materials automatically. The REGA instrument consists of four primary components: (1) a flight-proven mass spectrometer, (2) a high-temperature furnace, (3) a soil handling system, and (4) a microcontroller. An external arm containing a scoop or drill gathers regolith samples. A sample is placed in the inlet orifice where the finest-grained particles are sifted into a metering volume and subsequently moved into a crucible. A movable arm then places the crucible in the furnace. The furnace is closed, thereby sealing the inner volume to collect the evolved gases for analysis. Owing to the very low g forces on an asteroid compared to Mars or the moon, the sample must be moved from inlet to crucible by mechanical means rather than by gravity. As the soil sample is heated through a programmed pattern, the gases evolved at each temperature are passed through a transfer tube to the mass spectrometer for analysis and identification. Return data from the instrument will lead to new insights and discoveries including: (1) Identification of the molecular masses of all of the gases

  5. A physical model for z ~ 2 dust-obscured galaxies

    Science.gov (United States)

    Narayanan, Desika; Dey, Arjun; Hayward, Christopher C.; Cox, Thomas J.; Bussmann, R. Shane; Brodwin, Mark; Jonsson, Patrik; Hopkins, Philip F.; Groves, Brent; Younger, Joshua D.; Hernquist, Lars

    2010-09-01

    We present a physical model for the origin of z ~ 2 dust-obscured galaxies (DOGs), a class of high-redshift ultraluminous infrared galaxies (ULIRGs) selected at 24μm which are particularly optically faint (F24μm/FR > 1000). By combining N-body/smoothed particle hydrodynamic simulations of high-redshift galaxy evolution with 3D polychromatic dust radiative transfer models, we find that luminous DOGs (with F24 >~ 0.3mJy at z ~ 2) are well modelled as extreme gas-rich mergers in massive (~5 × 1012-1013Msolar) haloes, with elevated star formation rates (SFR; ~500-1000Msolaryr-1) and/or significant active galactic nuclei (AGN) growth , whereas less luminous DOGs are more diverse in nature. At final coalescence, merger-driven DOGs transition from being starburst dominated to AGN dominated, evolving from a `bump' to a power-law (PL) shaped mid-IR (Infrared Array Camera, IRAC) spectral energy distribution (SED). After the DOG phase, the galaxy settles back to exhibiting a `bump' SED with bluer colours and lower SFRs. While canonically PL galaxies are associated with being AGN dominated, we find that the PL mid-IR SED can owe both to direct AGN contribution and to a heavily dust obscured stellar bump at times that the galaxy is starburst dominated. Thus, PL galaxies can be either starburst or AGN dominated. Less luminous DOGs can be well-represented either by mergers or by massive (Mbaryon ~ 5 × 1011Msolar) secularly evolving gas-rich disc galaxies (with SFR >~ 50Msolaryr-1). By utilizing similar models as those employed in the submillimetre galaxy (SMG) formation study of Narayanan et al., we investigate the connection between DOGs and SMGs. We find that the most heavily star-forming merger-driven DOGs can be selected as submillimetre galaxies, while both merger-driven and secularly evolving DOGs typically satisfy the BzK selection criteria. The model SEDs from the simulated galaxies match observed data reasonably well, though Mrk 231 and Arp 220 templates provide

  6. The Bright and Dark Sides of High-redshift Starburst Galaxies from Herschel and Subaru Observations

    Energy Technology Data Exchange (ETDEWEB)

    Puglisi, A.; Rodighiero, G.; Rodríguez-Muñoz, L.; Mancini, C.; Franceschini, A. [Dipartimento di Fisica e Astronomia, Università di Padova, vicolo dell’Osservatorio 2, I-35122 Padova (Italy); Daddi, E.; Valentino, F.; Calabrò, A.; Jin, S. [Laboratoire AIM-Paris-Saclay, CEA/DSM-CNRS-Université Paris Diderot, IRFU/Service d’Astrophysique, CEA Saclay, Orme des Merisiers, F-91191 Gif-sur-Yvette (France); Renzini, A. [INAF-Osservatorio Astronomico di Padova, Vicolo dell’Osservatorio, 5, I-35122 Padova (Italy); Silverman, J. D. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for for Advanced Study, The University of Tokyo, Kashiwanoha, Kashiwa 277-8583 (Japan); Kashino, D. [Institute for Astronomy, Department of Physics, ETH Zürich, Wolfgang-Pauli-strasse 27, CH-8093 Zürich (Switzerland); Mainieri, V.; Man, A. [ESO, Karl-Schwarschild-Straße 2, D-85748 Garching bei München (Germany); Darvish, B. [Cahill Center for Astrophysics, California Institute of Technology, 1216 East California Boulevard, Pasadena, CA 91125 (United States); Maier, C. [University of Vienna, Department of Astrophysics, Tuerkenschanzstrasse 17, A-1180 Vienna (Austria); Kartaltepe, J. S. [National Optical Astronomy Observatory, 950 N. Cherry Avenue, Tucson, AZ 85719 (United States); Sanders, D. B. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2017-04-01

    We present rest-frame optical spectra from the FMOS-COSMOS survey of 12 z ∼ 1.6 Herschel starburst galaxies, with star formation rate (SFR) elevated by ×8, on average, above the star-forming main sequence (MS). Comparing the H α to IR luminosity ratio and the Balmer decrement, we find that the optically thin regions of the sources contain on average only ∼10% of the total SFR, whereas ∼90% come from an extremely obscured component that is revealed only by far-IR observations and is optically thick even in H α . We measure the [N ii]{sub 6583}/H α ratio, suggesting that the less obscured regions have a metal content similar to that of the MS population at the same stellar masses and redshifts. However, our objects appear to be metal-rich outliers from the metallicity–SFR anticorrelation observed at fixed stellar mass for the MS population. The [S ii]{sub 6732}/[S ii]{sub 6717} ratio from the average spectrum indicates an electron density n {sub e} ∼ 1100 cm{sup −3} , larger than what was estimated for MS galaxies but only at the 1.5 σ level. Our results provide supporting evidence that high- z MS outliers are analogous of local ULIRGs and are consistent with a major-merger origin for the starburst event.

  7. Comparing Local Starbursts to High-Redshift Galaxies: A Search for Lyman-Break Analogs

    Science.gov (United States)

    Petty, Sara M.; de Mello, Duila F.; Gallagher III, John S.; Gardner, Jonathan; Lotz, Jennifer M.; Mountain, C. Matt; Smith, Linda J.

    2008-01-01

    We compare the restframe far-ultraviolet (FUV) morphologies of 8 nearby interacting and starburst galaxies (Arp 269, M 82, Mrk 08, NGC 0520, NGC 1068, NGC 3079, NGC 3310, NGC 7673) with 54 galaxies at z approx.1.5 and 46 galaxies at z approx.4 in the Great Observatories Origins Deep Survey (GOODS) images taken with the Advanced Camera for Surveys onboard the Hubble Space Telescope. We calculate the Gini coefficient (G), the second order moment of 20% of the brightest pixels (M20), and the S ersic index (n). We find that 20% (11/54) of z approx.1.5 and 37% (17/46) of z approx.4 galaxies are bulge-like, using G and M20. We also find approx.70% of the z approx.1.5 and z approx.4 galaxies have exponential disks with n > 0.8. The 2D profile combined with the nonparametric methods provides more detail, concerning the nature of disturbed systems, such as merger and post-merger types. We also provide qualitative descriptions of each galaxy system and at each redshift. We conclude that Mrk 08, NGC 3079, and NGC 7673 have similar morphologies as the starburst FUV restframe galaxies and Lyman-break galaxies at z approx.1.5 and 4, and determine that they are Lyman-break analogs.

  8. Herschel-ATLAS: A Binary HyLIRG Pinpointing a Cluster of Starbursting Protoellipticals

    Science.gov (United States)

    Ivison, R.J.; Swinbank, A.M.; Smail, Ian; Harris, A. I.; Bussmann, R. S.; Cooray, A.; Cox, P.; Fu, H.; Kovacs, A.; Krips, M.; hide

    2013-01-01

    Panchromatic observations of the best candidate hyperluminous infrared galaxies from the widest Herschel extragalactic imaging survey have led to the discovery of at least four intrinsically luminous z = 2.41 galaxies across an ˜100 kpc region-a cluster of starbursting protoellipticals. Via subarcsecond interferometric imaging we have measured accurate gas and star formation surface densities. The two brightest galaxies span 3 kpc FWHM in submillimeter/radio continuum and CO J = 4-3, and double that in CO J = 1-0. The broad CO line is due partly to the multitude of constituent galaxies and partly to large rotational velocities in two counter-rotating gas disks-a scenario predicted to lead to the most intense starbursts, which will therefore come in pairs. The disks have Mdyn of several ×10(sup 11) solar Mass, and gas fractions of 40%. Velocity dispersions are modest so the disks are unstable, potentially on scales commensurate with their radii: these galaxies are undergoing extreme bursts of star formation, not confined to their nuclei, at close to the Eddington limit. Their specific star formation rates place them greater than or approx. equal to 5 × above the main sequence, which supposedly comprises large gas disks like these. Their high star formation efficiencies are difficult to reconcile with a simple volumetric star formation law. N-body and dark matter simulations suggest that this system is the progenitor of a B(inary)-type ˜10(sup 14.6) -solar mass cluster.

  9. Far-infrared spectroscopy of a lensed starburst: a blind redshift from Herschel

    Science.gov (United States)

    George, R. D.; Ivison, R. J.; Hopwood, R.; Riechers, D. A.; Bussmann, R. S.; Cox, P.; Dye, S.; Krips, M.; Negrello, M.; Neri, R.; Serjeant, S.; Valtchanov, I.; Baes, M.; Bourne, N.; Clements, D. L.; De Zotti, G.; Dunne, L.; Eales, S. A.; Ibar, E.; Maddox, S.; Smith, M. W. L.; Valiante, E.; van der Werf, P.

    2013-11-01

    We report the redshift of HATLAS J132427.0+284452 (hereafter HATLAS J132427), a gravitationally lensed starburst galaxy, the first determined `blind' by the Herschel Space Observatory. This is achieved via the detection of [C II] consistent with z = 1.68 in a far-infrared spectrum taken with the SPIRE Fourier Transform Spectrometer (FTS). We demonstrate that the [C II] redshift is secure via detections of CO J = 2 → 1 and 3 → 2 using the Combined Array for Research in Millimeter-wave Astronomy and the Institut de Radioastronomie Millimétrique's Plateau de Bure Interferometer. The intrinsic properties appear typical of high-redshift starbursts despite the high lensing-amplified fluxes, proving the ability of the FTS to probe this population with the aid of lensing. The blind detection of [C II] demonstrates the potential of the SPICA Far-infrared Instrument imaging spectrometer, proposed for the much more sensitive Space Infrared Telescope for Cosmology and Astrophysics mission, to determine redshifts of multiple dusty galaxies simultaneously without the benefit of lensing.

  10. Primordial evolvability: Impasses and challenges.

    Science.gov (United States)

    Vasas, Vera; Fernando, Chrisantha; Szilágyi, András; Zachár, István; Santos, Mauro; Szathmáry, Eörs

    2015-09-21

    While it is generally agreed that some kind of replicating non-living compounds were the precursors of life, there is much debate over their possible chemical nature. Metabolism-first approaches propose that mutually catalytic sets of simple organic molecules could be capable of self-replication and rudimentary chemical evolution. In particular, the graded autocatalysis replication domain (GARD) model, depicting assemblies of amphiphilic molecules, has received considerable interest. The system propagates compositional information across generations and is suggested to be a target of natural selection. However, evolutionary simulations indicate that the system lacks selectability (i.e. selection has negligible effect on the equilibrium concentrations). We elaborate on the lessons learnt from the example of the GARD model and, more widely, on the issue of evolvability, and discuss the implications for similar metabolism-first scenarios. We found that simple incorporation-type chemistry based on non-covalent bonds, as assumed in GARD, is unlikely to result in alternative autocatalytic cycles when catalytic interactions are randomly distributed. An even more serious problem stems from the lognormal distribution of catalytic factors, causing inherent kinetic instability of such loops, due to the dominance of efficiently catalyzed components that fail to return catalytic aid. Accordingly, the dynamics of the GARD model is dominated by strongly catalytic, but not auto-catalytic, molecules. Without effective autocatalysis, stable hereditary propagation is not possible. Many repetitions and different scaling of the model come to no rescue. Despite all attempts to show the contrary, the GARD model is not evolvable, in contrast to reflexively autocatalytic networks, complemented by rare uncatalyzed reactions and compartmentation. The latter networks, resting on the creation and breakage of chemical bonds, can generate novel ('mutant') autocatalytic loops from a given set of

  11. The optical versus mid-infrared spectral properties of 82 Type 1 AGNs: coevolution of AGN and starburst

    Science.gov (United States)

    Lakićević, Maša; Kovačević-Dojčinović, Jelena; Popović, Luka Č.

    2017-11-01

    We investigated the connection between the mid-infrared (MIR) and optical spectral characteristics in a sample of 82 Type 1 active galactic nuclei (AGNs), observed with Infrared Spectrometer on Spitzer (IRS) and Sloan Digital Sky Survey (SDSS, DR12). We found several interesting correlations between optical and MIR spectral properties: (i) as starburst significators in MIR increase, the equivalent widths (EWs) of optical lines H βNLR and Fe ii, increase as well; (ii) as MIR spectral index increases, EW([O III]) decreases, while fractional contribution of AGN (RAGN) is not connected with EW([O III]); (iii) The log([O III]5007/H βNLR) ratio is weakly related to the fractional contribution of polycyclic aromatic hydrocarbons (RPAHs). We compare the two different MIR and optical diagnostics for starburst contribution to the overall radiation (RPAH and Baldwin, Philips & Terlevich diagram, respectively). The significant differences between optical and MIR starburst diagnostics were found. The starburst influence to observed correlations between optical and MIR parameters is discussed.

  12. Thinking Through Computational Exposure as an Evolving Paradign Shift for Exposure Science: Development and Application of Predictive Models from Big Data

    Science.gov (United States)

    Symposium Abstract: Exposure science has evolved from a time when the primary focus was on measurements of environmental and biological media and the development of enabling field and laboratory methods. The Total Exposure Assessment Method (TEAM) studies of the 1980s were class...

  13. Survey of Water and Ammonia in Nearby Galaxies (SWAN): Resolved Ammonia Thermometry, and Water and Methanol Masers in the Nuclear Starburst of NGC 253

    Science.gov (United States)

    Gorski, Mark; Ott, Jürgen; Rand, Richard; Meier, David S.; Momjian, Emmanuel; Schinnerer, Eva

    2017-06-01

    We present Karl G. Jansky Very Large Array molecular line observations of the nearby starburst galaxy NGC 253, from SWAN, the Survey of Water and Ammonia in Nearby galaxies. SWAN is a molecular line survey at centimeter wavelengths designed to reveal the physical conditions of star-forming gas over a range of star-forming galaxies. NGC 253 has been observed in four 1 GHz bands from 21 to 36 GHz at 6″ ˜ 100 pc) spatial and 3.5 km s-1 spectral resolution. In total we detect 19 transitions from 7 molecular and atomic species. We have targeted the metastable inversion transitions of ammonia (NH3) from (1, 1) to (5, 5) and the (9, 9) line, the 22.2 GHz water (H2O) ({6}16{--}{5}23) maser, and the 36.1 GHz methanol (CH3OH) ({4}-1{--}{3}0) maser. Using NH3 as a thermometer, we present evidence for uniform heating over the central kpc of NGC 253. The molecular gas is best described by a two kinetic temperature model with a warm 130 K and a cooler 57 K component. A comparison of these observations with previous ALMA results suggests that the molecular gas is not heated in photon-dominated regions or shocks. It is possible that the gas is heated by turbulence or cosmic rays. In the galaxy center we find evidence for NH3(3, 3) masers. Furthermore, we present velocities and luminosities of three water maser features related to the nuclear starburst. We partially resolve CH3OH masers seen at the edges of the bright molecular emission, which coincides with expanding molecular superbubbles. This suggests that the masers are pumped by weak shocks in the bubble surfaces.

  14. SPECTRAL ANALYSIS AND INTERPRETATION OF THE {gamma}-RAY EMISSION FROM THE STARBURST GALAXY NGC 253

    Energy Technology Data Exchange (ETDEWEB)

    Abramowski, A. [Institut fuer Experimentalphysik, Universitaet Hamburg, Luruper Chaussee 149, D-22761 Hamburg (Germany); Acero, F. [Laboratoire Univers et Particules de Montpellier, Universite Montpellier 2, CNRS/IN2P3, CC 72, Place Eugene Bataillon, F-34095 Montpellier Cedex 5 (France); Aharonian, F.; Bernloehr, K.; Bochow, A. [Max-Planck-Institut fuer Kernphysik, P.O. Box 103980, D-69029 Heidelberg (Germany); Akhperjanian, A. G. [National Academy of Sciences of the Republic of Armenia, Yerevan (Armenia); Anton, G.; Balzer, A.; Brucker, J. [Physikalisches Institut, Universitaet Erlangen-Nuernberg, Erwin-Rommel-Str. 1, D-91058 Erlangen (Germany); Barnacka, A. [Nicolaus Copernicus Astronomical Center, ul. Bartycka 18, 00-716 Warsaw (Poland); Becherini, Y. [APC, AstroParticule et Cosmologie, Universite Paris Diderot, CNRS/IN2P3, CEA/lrfu, Observatoire de Paris, Sorbonne Paris Cite, 10, rue Alice Domon et Leonie Duquet, F-75205 Paris Cedex 13 (France); Becker, J. [Institut fuer Theoretische Physik, Lehrstuhl IV: Weltraum und Astrophysik, Ruhr-Universitaet Bochum, D-44780 Bochum (Germany); Birsin, E. [Institut fuer Physik, Humboldt-Universitaet zu Berlin, Newtonstr. 15, D-12489 Berlin (Germany); Biteau, J.; Brun, F. [Laboratoire Leprince-Ringuet, Ecole Polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); Boisson, C. [LUTH, Observatoire de Paris, CNRS, Universite Paris Diderot, 5 Place Jules Janssen, F-92190 Meudon (France); Bolmont, J. [LPNHE, Universite Pierre et Marie Curie Paris 6, Universite Denis Diderot Paris 7, CNRS/IN2P3, 4 Place Jussieu, F-75252, Paris Cedex 5 (France); Bordas, P. [Institut fuer Astronomie und Astrophysik, Universitaet Tuebingen, Sand 1, D-72076 Tuebingen (Germany); Brun, P. [CEA Saclay, DSM/IRFU, F-91191 Gif-Sur-Yvette Cedex (France); Bulik, T., E-mail: stefan.ohm@le.ac.uk [Astronomical Observatory, The University of Warsaw, Al. Ujazdowskie 4, 00-478 Warsaw (Poland); Collaboration: H.E.S.S. Collaboration; and others

    2012-10-01

    Very high energy (VHE; E {>=} 100 GeV) and high-energy (HE; 100 MeV {<=} E {<=} 100 GeV) data from {gamma}-ray observations performed with the H.E.S.S. telescope array and the Fermi-LAT instrument, respectively, are analyzed in order to investigate the non-thermal processes in the starburst galaxy NGC 253. The VHE {gamma}-ray data can be described by a power law in energy with differential photon index {Gamma} = 2.14 {+-} 0.18{sub stat} {+-} 0.30{sub sys} and differential flux normalization at 1 TeV of F{sub 0} = (9.6 {+-} 1.5{sub stat}(+ 5.7, -2.9){sub sys}) Multiplication-Sign 10{sup -14} TeV{sup -1} cm{sup -2} s{sup -1}. A power-law fit to the differential HE {gamma}-ray spectrum reveals a photon index of {Gamma} 2.24 {+-} 0.14{sub stat} {+-} 0.03{sub sys} and an integral flux between 200 MeV and 200 GeV of F(0.2-200 GeV) = (4.9 {+-} 1.0{sub stat} {+-} 0.3{sub sys}) Multiplication-Sign 10{sup -9} cm{sup -2} s{sup -1}. No evidence for a spectral break or turnover is found over the dynamic range of both the LAT instrument and the H.E.S.S. experiment: a combined fit of a power law to the HE and VHE {gamma}-ray data results in a differential photon index {Gamma} = 2.34 {+-} 0.03 with a p-value of 30%. The {gamma}-ray observations indicate that at least about 20% of the energy of the cosmic rays (CRs) capable of producing hadronic interactions is channeled into pion production. The smooth alignment between the spectra in the HE and VHE {gamma}-ray domain suggests that the same transport processes dominate in the entire energy range. Advection is most likely responsible for charged particle removal from the starburst nucleus from GeV to multiple TeV energies. In a hadronic scenario for the {gamma}-ray production, the single overall power-law spectrum observed would therefore correspond to the mean energy spectrum produced by the ensemble of CR sources in the starburst region.

  15. Fat: an evolving issue

    Directory of Open Access Journals (Sweden)

    John R. Speakman

    2012-09-01

    Work on obesity is evolving, and obesity is a consequence of our evolutionary history. In the space of 50 years, we have become an obese species. The reasons why can be addressed at a number of different levels. These include separating between whether the primary cause lies on the food intake or energy expenditure side of the energy balance equation, and determining how genetic and environmental effects contribute to weight variation between individuals. Opinion on whether increased food intake or decreased energy expenditure drives the obesity epidemic is still divided, but recent evidence favours the idea that food intake, rather than altered expenditure, is most important. There is more of a consensus that genetics explains most (probably around 65% of weight variation between individuals. Recent advances in genome-wide association studies have identified many polymorphisms that are linked to obesity, yet much of the genetic variance remains unexplained. Finding the causes of this unexplained variation will be an impetus of genetic and epigenetic research on obesity over the next decade. Many environmental factors – including gut microbiota, stress and endocrine disruptors – have been linked to the risk of developing obesity. A better understanding of gene-by-environment interactions will also be key to understanding obesity in the years to come.

  16. Evolving Concepts of Asthma

    Science.gov (United States)

    Ray, Anuradha; Wenzel, Sally E.

    2015-01-01

    Our understanding of asthma has evolved over time from a singular disease to a complex of various phenotypes, with varied natural histories, physiologies, and responses to treatment. Early therapies treated most patients with asthma similarly, with bronchodilators and corticosteroids, but these therapies had varying degrees of success. Similarly, despite initial studies that identified an underlying type 2 inflammation in the airways of patients with asthma, biologic therapies targeted toward these type 2 pathways were unsuccessful in all patients. These observations led to increased interest in phenotyping asthma. Clinical approaches, both biased and later unbiased/statistical approaches to large asthma patient cohorts, identified a variety of patient characteristics, but they also consistently identified the importance of age of onset of disease and the presence of eosinophils in determining clinically relevant phenotypes. These paralleled molecular approaches to phenotyping that developed an understanding that not all patients share a type 2 inflammatory pattern. Using biomarkers to select patients with type 2 inflammation, repeated trials of biologics directed toward type 2 cytokine pathways saw newfound success, confirming the importance of phenotyping in asthma. Further research is needed to clarify additional clinical and molecular phenotypes, validate predictive biomarkers, and identify new areas for possible interventions. PMID:26161792

  17. Evolving endoscopic surgery.

    Science.gov (United States)

    Sakai, Paulo; Faintuch, Joel

    2014-06-01

    Since the days of Albukasim in medieval Spain, natural orifices have been regarded not only as a rather repugnant source of bodily odors, fluids and excreta, but also as a convenient invitation to explore and treat the inner passages of the organism. However, surgical ingenuity needed to be matched by appropriate tools and devices. Lack of technologically advanced instrumentation was a strong deterrent during almost a millennium until recent decades when a quantum jump materialized. Endoscopic surgery is currently a vibrant and growing subspecialty, which successfully handles millions of patients every year. Additional opportunities lie ahead which might benefit millions more, however, requiring even more sophisticated apparatuses, particularly in the field of robotics, artificial intelligence, and tissue repair (surgical suturing). This is a particularly exciting and worthwhile challenge, namely of larger and safer endoscopic interventions, followed by seamless and scarless recovery. In synthesis, the future is widely open for those who use together intelligence and creativity to develop new prototypes, new accessories and new techniques. Yet there are many challenges in the path of endoscopic surgery. In this new era of robotic endoscopy, one will likely need a virtual simulator to train and assess the performance of younger doctors. More evidence will be essential in multiple evolving fields, particularly to elucidate whether more ambitious and complex pathways, such as intrathoracic and intraperitoneal surgery via natural orifice transluminal endoscopic surgery (NOTES), are superior or not to conventional techniques. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  18. Evolving a photosynthetic organelle

    Directory of Open Access Journals (Sweden)

    Nakayama Takuro

    2012-04-01

    Full Text Available Abstract The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles. The plastids, or chloroplasts, of algae and plants evolved from cyanobacteria by endosymbiosis. This landmark event conferred on eukaryotes the benefits of photosynthesis - the conversion of solar energy into chemical energy - and in so doing had a huge impact on the course of evolution and the climate of Earth 1. From the present state of plastids, however, it is difficult to trace the evolutionary steps involved in this momentous development, because all modern-day plastids have fully integrated into their hosts. Paulinella chromatophora is a unicellular eukaryote that bears photosynthetic entities called chromatophores that are derived from cyanobacteria and has thus received much attention as a possible example of an organism in the early stages of organellogenesis. Recent studies have unlocked the genomic secrets of its chromatophore 23 and provided concrete evidence that the Paulinella chromatophore is a bona fide photosynthetic organelle 4. The question is how Paulinella can help us to understand the process by which an endosymbiont is converted into an organelle.

  19. Molecular gas in low-metallicity starburst galaxies:. Scaling relations and the CO-to-H2 conversion factor

    Science.gov (United States)

    Amorín, R.; Muñoz-Tuñón, C.; Aguerri, J. A. L.; Planesas, P.

    2016-04-01

    Context. Tracing the molecular gas-phase in low-mass star-forming galaxies becomes extremely challenging due to significant UV photo-dissociation of CO molecules in their low-dust, low-metallicity ISM environments. Aims: We aim to study the molecular content and the star-formation efficiency of a representative sample of 21 blue compact dwarf galaxies (BCDs), previously characterized on the basis of their spectrophotometric properties. Methods: We present CO (1-0) and (2-1) observations conducted at the IRAM-30m telescope. These data are further supplemented with additional CO measurements and multiwavelength ancillary data from the literature. We explore correlations between the derived CO luminosities and several galaxy-averaged properties. Results: We detect CO emission in seven out of ten BCDs observed. For two galaxies these are the first CO detections reported so far. We find the molecular content traced by CO to be correlated with the stellar and Hi masses, star formation rate (SFR) tracers, the projected size of the starburst, and its gas-phase metallicity. BCDs appear to be systematically offset from the Schmidt-Kennicutt (SK) law, showing lower average gas surface densities for a given ΣSFR, and therefore showing extremely low (≲0.1 Gyr) H2 and H2 +Hi depletion timescales. The departure from the SK law is smaller when considering H2 +Hi rather than H2 only, and is larger for BCDs with lower metallicity and higher specific SFR. Thus, the molecular fraction (ΣH2/ ΣHI) and CO depletion timescale (ΣH2/ ΣSFR) of BCDs is found to be strongly correlated with metallicity. Using this, and assuming that the empirical correlation found between the specific SFR and galaxy-averaged H2 depletion timescale of more metal-rich galaxies extends to lower masses, we derive a metallicity-dependent CO-to-H2 conversion factor αCO,Z ∝ (Z/Z⊙)- y, with y = 1.5(±0.3)in qualitative agreement with previous determinations, dust-based measurements, and recent model

  20. The Environment of X-Ray Binaries in the Dwarf Starburst Galaxy NGC 1569

    Science.gov (United States)

    Clark, David M.; Eikenberry, Stephen S.; Raines, Steven N.

    2008-05-01

    We use deep, J and Ks observations of NGC 1569 acquired with FLAMINGOS on the KPNO 4-m to search for star cluster counterparts to X-ray binaries identified in archived Chandra images of this dwarf starburst galaxy. Performing near-IR photometry on the star cluster counterparts, we determine their colors, luminosities and masses. Comparing these results to the properties for all clusters in this galaxy, we search for trends in clusters associated with X-ray sources. Combining this study with FISICA, near-IR spectral observations, we further characterize the surroundings to X-ray binaries in NGC 1569. Contrasting this work with findings from a similar study performed on the Antennae galaxies, a large, merging system, we investigate the differences in X-ray binary environments.

  1. The radio core structure of the luminous infrared galaxy NGC 4418. A young clustered starburst revealed?

    Science.gov (United States)

    Varenius, E.; Conway, J. E.; Martí-Vidal, I.; Aalto, S.; Beswick, R.; Costagliola, F.; Klöckner, H.-R.

    2014-06-01

    Context. The galaxy NGC 4418 contains one of the most compact obscured nuclei within a luminous infrared galaxy (LIRG) in the nearby Universe. This nucleus contains a rich molecular gas environment and an unusually high ratio of infrared-to-radio luminosity (q-factor). The compact nucleus is powered by either a compact starburst or an active galactic nucleus (AGN). Aims: The aim of this study is to constrain the nature of the nuclear region (starburst or AGN) within NGC 4418 via very-high-resolution radio imaging. Methods: Archival data from radio observations using the European Very Long Baseline Interferometry Network (EVN) and Multi-Element Radio Linked Interferometer Network (MERLIN) interferometers are imaged. Sizes and flux densities are obtained by fitting Gaussian intensity distributions to the image. The average spectral index of the compact radio emission is estimated from measurements at 1.4 GHz and 5.0 GHz. Results: The nuclear structure of NGC 4418 visible with EVN and MERLIN consists of eight compact (104.8 K indicate that these compact features cannot be HII-regions. The complex morphology and inverted spectrum of the eight detected compact features is evidence against the hypothesis that an AGN alone is powering the nucleus of NGC 4418. The compact features could be super star clusters with intense star formation, and their associated free-free absorption could then naturally explain both their inverted radio spectrum and the low radio-to-IR ratio of the nucleus. The required star formation area density is extreme, however, and close to the limit of what can be observed in a well-mixed thermal/non-thermal plasma produced by star formation, and is also close to the limit of what can be physically sustained.

  2. HERSCHEL-ATLAS: A BINARY HyLIRG PINPOINTING A CLUSTER OF STARBURSTING PROTOELLIPTICALS

    Energy Technology Data Exchange (ETDEWEB)

    Ivison, R. J. [UK Astronomy Technology Centre, Science and Technology Facilities Council, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Swinbank, A. M.; Smail, Ian [Institute for Computational Cosmology, Durham University, South Road, Durham DH1 3LE (United Kingdom); Harris, A. I. [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Bussmann, R. S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St, Cambridge, MA 02138 (United States); Cooray, A.; Fu, H. [Department of Physics and Astronomy, University of California, Irvine, CA 92697 (United States); Cox, P.; Krips, M.; Neri, R. [Institut de Radioastronomie Millimetrique, 300 rue de la Piscine, F-38406 Saint-Martin d' Heres (France); Kovacs, A. [Department of Astronomy, University of Minnesota, Minneapolis, MN 55414 (United States); Narayanan, D. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Negrello, M. [INAF, Osservatorio Astronomico di Padova, I-35122 Padova (Italy); Penarrubia, J.; Targett, T. A. [Institute for Astronomy, University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Richard, J. [Centre de Recherche Astrophysique de Lyon, Universite Lyon 1, 9 Avenue Charles Andre, F-69561 Saint Genis Laval Cedex (France); Riechers, D. A. [Department of Astronomy, Space Science Building, Cornell University, Ithaca, NY 14853-6801 (United States); Rowlands, K. [School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Staguhn, J. G. [The Henry A. Rowland Department of Physics and Astronomy, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 (United States); Amber, S. [Department of Physical Sciences, The Open University, Milton Keynes (United Kingdom); and others

    2013-08-01

    Panchromatic observations of the best candidate hyperluminous infrared galaxies from the widest Herschel extragalactic imaging survey have led to the discovery of at least four intrinsically luminous z = 2.41 galaxies across an Almost-Equal-To 100 kpc region-a cluster of starbursting protoellipticals. Via subarcsecond interferometric imaging we have measured accurate gas and star formation surface densities. The two brightest galaxies span {approx}3 kpc FWHM in submillimeter/radio continuum and CO J = 4-3, and double that in CO J = 1-0. The broad CO line is due partly to the multitude of constituent galaxies and partly to large rotational velocities in two counter-rotating gas disks-a scenario predicted to lead to the most intense starbursts, which will therefore come in pairs. The disks have M{sub dyn} of several Multiplication-Sign 10{sup 11} M{sub Sun }, and gas fractions of {approx}40%. Velocity dispersions are modest so the disks are unstable, potentially on scales commensurate with their radii: these galaxies are undergoing extreme bursts of star formation, not confined to their nuclei, at close to the Eddington limit. Their specific star formation rates place them {approx}> 5 Multiplication-Sign above the main sequence, which supposedly comprises large gas disks like these. Their high star formation efficiencies are difficult to reconcile with a simple volumetric star formation law. N-body and dark matter simulations suggest that this system is the progenitor of a B(inary)-type Almost-Equal-To 10{sup 14.6}-M{sub Sun} cluster.

  3. A Widespread, Clumpy Starburst in the Isolated Ongoing Dwarf Galaxy Merger dm1647+21

    Science.gov (United States)

    Privon, G. C.; Stierwalt, S.; Patton, D. R.; Besla, G.; Pearson, S.; Putman, M.; Johnson, K. E.; Kallivayalil, N.; Liss, S.; Titans, TiNy

    2017-09-01

    Interactions between pairs of isolated dwarf galaxies provide a critical window into low-mass hierarchical, gas-dominated galaxy assembly and the build-up of stellar mass in low-metallicity systems. We present the first Very Large Telescope/Multi Unit Spectroscopic Explorer (VLT/MUSE) optical integral field unit (IFU) observations of the interacting dwarf pair dm1647+21 selected from the TiNy Titans survey. The Hα emission is widespread and corresponds to a total unobscured star formation rate (SFR) of 0.44 M ⊙ yr-1, which is 2.7 times higher than the SFR inferred from Sloan Digital Sky Survey (SDSS) data. The implied specific SFR (sSFR) for the system is elevated by more than an order of magnitude above non-interacting dwarfs in the same mass range. This increase is dominated by the lower-mass galaxy, which has a sSFR enhancement of >50. Examining the spatially resolved maps of classic optical line diagnostics, we find that the interstellar medium (ISM) excitation can be fully explained by star formation. The velocity field of the ionized gas is not consistent with simple rotation. Dynamical simulations indicate that the irregular velocity field and the stellar structure is consistent with the identification of this system as an ongoing interaction between two dwarf galaxies. The widespread, clumpy enhancements in the star formation in this system point to important differences in the effect of mergers on dwarf galaxies, compared to massive galaxies; rather than the funneling of gas to the nucleus and giving rise to a nuclear starburst, starbursts in low-mass galaxy mergers may be triggered by large-scale ISM compression, and thus may be more distributed.

  4. A Widespread, Clumpy Starburst in the Isolated Ongoing Dwarf Galaxy Merger dm1647+21

    Energy Technology Data Exchange (ETDEWEB)

    Privon, G. C. [Instituto de Astrofśica, Facultad de Física, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 22 (Chile); Stierwalt, S.; Johnson, K. E.; Kallivayalil, N.; Liss, S. [Department of Astronomy, University of Virginia, 530 McCormick Road, Charlottesville, VA 22904 (United States); Patton, D. R. [Department of Physics and Astronomy, Trent University, 1600 West Bank Drive, Peterborough, ON K9L 0G2 (Canada); Besla, G. [Department of Astronomy, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Pearson, S.; Putman, M., E-mail: gprivon@astro.puc.cl [Department of Astronomy, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Collaboration: TiNy Titans

    2017-09-01

    Interactions between pairs of isolated dwarf galaxies provide a critical window into low-mass hierarchical, gas-dominated galaxy assembly and the build-up of stellar mass in low-metallicity systems. We present the first Very Large Telescope/Multi Unit Spectroscopic Explorer (VLT/MUSE) optical integral field unit (IFU) observations of the interacting dwarf pair dm1647+21 selected from the TiNy Titans survey. The H α emission is widespread and corresponds to a total unobscured star formation rate (SFR) of 0.44 M {sub ⊙} yr{sup −1}, which is 2.7 times higher than the SFR inferred from Sloan Digital Sky Survey (SDSS) data. The implied specific SFR (sSFR) for the system is elevated by more than an order of magnitude above non-interacting dwarfs in the same mass range. This increase is dominated by the lower-mass galaxy, which has a sSFR enhancement of >50. Examining the spatially resolved maps of classic optical line diagnostics, we find that the interstellar medium (ISM) excitation can be fully explained by star formation. The velocity field of the ionized gas is not consistent with simple rotation. Dynamical simulations indicate that the irregular velocity field and the stellar structure is consistent with the identification of this system as an ongoing interaction between two dwarf galaxies. The widespread, clumpy enhancements in the star formation in this system point to important differences in the effect of mergers on dwarf galaxies, compared to massive galaxies; rather than the funneling of gas to the nucleus and giving rise to a nuclear starburst, starbursts in low-mass galaxy mergers may be triggered by large-scale ISM compression, and thus may be more distributed.

  5. Natural selection promotes antigenic evolvability

    NARCIS (Netherlands)

    Graves, C.J.; Ros, V.I.D.; Stevenson, B.; Sniegowski, P.D.; Brisson, D.

    2013-01-01

    The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide

  6. Disgust: Evolved function and structure

    NARCIS (Netherlands)

    Tybur, J.M.; Lieberman, D.; Kurzban, R.; DeScioli, P.

    2013-01-01

    Interest in and research on disgust has surged over the past few decades. The field, however, still lacks a coherent theoretical framework for understanding the evolved function or functions of disgust. Here we present such a framework, emphasizing 2 levels of analysis: that of evolved function and

  7. Evolving virtual creatures and catapults.

    Science.gov (United States)

    Chaumont, Nicolas; Egli, Richard; Adami, Christoph

    2007-01-01

    We present a system that can evolve the morphology and the controller of virtual walking and block-throwing creatures (catapults) using a genetic algorithm. The system is based on Sims' work, implemented as a flexible platform with an off-the-shelf dynamics engine. Experiments aimed at evolving Sims-type walkers resulted in the emergence of various realistic gaits while using fairly simple objective functions. Due to the flexibility of the system, drastically different morphologies and functions evolved with only minor modifications to the system and objective function. For example, various throwing techniques evolved when selecting for catapults that propel a block as far as possible. Among the strategies and morphologies evolved, we find the drop-kick strategy, as well as the systematic invention of the principle behind the wheel, when allowing mutations to the projectile.

  8. How the first biopolymers could have evolved.

    Science.gov (United States)

    Abkevich, V I; Gutin, A M; Shakhnovich, E I

    1996-01-01

    In this work, we discuss a possible origin of the first biopolymers with stable unique structures. We suggest that at the prebiotic stage of evolution, long organic polymers had to be compact to avoid hydrolysis and had to be soluble and thus must not be exceedingly hydrophobic. We present an algorithm that generates such sequences for model proteins. The evolved sequences turn out to have a stable unique structure, into which they quickly fold. This result illustrates the idea that the unique three-dimensional native structures of first biopolymers could have evolved as a side effect of nonspecific physicochemical factors acting at the prebiotic stage of evolution. PMID:8570645

  9. Modelling hourly dissolved oxygen concentration (DO) using dynamic evolving neural-fuzzy inference system (DENFIS)-based approach: case study of Klamath River at Miller Island Boat Ramp, OR, USA.

    Science.gov (United States)

    Heddam, Salim

    2014-01-01

    In this study, we present application of an artificial intelligence (AI) technique model called dynamic evolving neural-fuzzy inference system (DENFIS) based on an evolving clustering method (ECM), for modelling dissolved oxygen concentration in a river. To demonstrate the forecasting capability of DENFIS, a one year period from 1 January 2009 to 30 December 2009, of hourly experimental water quality data collected by the United States Geological Survey (USGS Station No: 420853121505500) station at Klamath River at Miller Island Boat Ramp, OR, USA, were used for model development. Two DENFIS-based models are presented and compared. The two DENFIS systems are: (1) offline-based system named DENFIS-OF, and (2) online-based system, named DENFIS-ON. The input variables used for the two models are water pH, temperature, specific conductance, and sensor depth. The performances of the models are evaluated using root mean square errors (RMSE), mean absolute error (MAE), Willmott index of agreement (d) and correlation coefficient (CC) statistics. The lowest root mean square error and highest correlation coefficient values were obtained with the DENFIS-ON method. The results obtained with DENFIS models are compared with linear (multiple linear regression, MLR) and nonlinear (multi-layer perceptron neural networks, MLPNN) methods. This study demonstrates that DENFIS-ON investigated herein outperforms all the proposed techniques for DO modelling.

  10. High-Resolution Near-Infrared Spectroscopy of an Equivalent Width-Selected Sample of Starbursting Dwarf Galaxies

    Science.gov (United States)

    Maseda, Michael V.; VanDerWeL, Arjen; DaChuna, Elisabete; Rix, Hans-Walter; Pacafichi, Camilla; Momcheva, Ivelina; Brammer, Gabriel B.; Franx, Marijn; VanDokkum, Pieter; Bell, Eric F.; hide

    2013-01-01

    Spectroscopic observations from the Large Binocular Telescope and the Very Large Telescope reveal kinematically narrow lines (approx. 50 km/s) for a sample of 14 Extreme Emission Line Galaxies (EELGs) at redshifts 1.4 < zeta < 2.3. These measurements imply that the total dynamical masses of these systems are low ( 3 × 10(exp 9) M). Their large [O III]5007 equivalent widths (500 - 1100 A) and faint blue continuum emission imply young ages of 10-100 Myr and stellar masses of 10(exp 8)-10(exp 9) M, confirming the presence of a violent starburst. The stellar mass formed in this vigorous starburst phase thus represents a large fraction of the total (dynamical) mass, without a significantly massive underlying population of older stars. The occurrence of such intense events in shallow potentials strongly suggests that supernova-driven winds must be of critical importance in the subsequent evolution of these systems.

  11. Evolution of evolvability in gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Anton Crombach

    Full Text Available Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes. For the last decade, the study of such networks has been fueled by large-scale experiments and renewed attention from the theoretical field. Different models have been proposed to, for instance, investigate expression dynamics, explain the network topology we observe in bacteria and yeast, and for the analysis of evolvability and robustness of such networks. Yet how these gene regulatory networks evolve and become evolvable remains an open question. An individual-oriented evolutionary model is used to shed light on this matter. Each individual has a genome from which its gene regulatory network is derived. Mutations, such as gene duplications and deletions, alter the genome, while the resulting network determines the gene expression pattern and hence fitness. With this protocol we let a population of individuals evolve under Darwinian selection in an environment that changes through time. Our work demonstrates that long-term evolution of complex gene regulatory networks in a changing environment can lead to a striking increase in the efficiency of generating beneficial mutations. We show that the population evolves towards genotype-phenotype mappings that allow for an orchestrated network-wide change in the gene expression pattern, requiring only a few specific gene indels. The genes involved are hubs of the networks, or directly influencing the hubs. Moreover, throughout the evolutionary trajectory the networks maintain their mutational robustness. In other words, evolution in an alternating environment leads to a network that is sensitive to a small class of beneficial mutations, while the majority of mutations remain neutral: an example of evolution of evolvability.

  12. Neon and [CII] 158 μm Emission Line Profiles in Dusty Starbursts and Active Galactic Nuclei

    Science.gov (United States)

    Samsonyan, A.; Weedman, D.; Lebouteiller, V.; Barry, D.; Sargsyan, L.

    2017-07-01

    Identifying and understanding the initial formation of massive galaxies and quasars in the early universe is a fundamental goal of observational cosmology. A rapidly developing capability for tracing luminosity sources to high redshifts is the observation of the [CII] 158 μm emission line at redshifts z > 4 using ground based submillimeter interferometers, with detections now having been made to z = 7. This has long been known as the strongest far-infrared line in most sources, often carrying about 1% of the total source luminosity, and is thought to be associated with star formation because it should arise within the photodissociation region (PDR) surrounding starbursts. The sample of 382 extragalactic sources has been analysed that have mid-infrared,high resolution spectroscopy with the Spitzer Infrared Spectrograph (IRS) and also spectroscopy of the [CII] 158 μm line with the Herschel Photodetector Array Camera and Spectrometer (PACS). The emission line profiles of [NeII] 12.81μm , [NeIII] 15.55 μm , and [CII] 158 μm are studied, and intrinsic line widths are determined. All line profiles together with overlays comparing positions of PACS and IRS observations are made available in the Cornell Atlas of Spitzer IRS Sources (CASSIS). Sources are classified from AGN to starburst based on equivalent widths of the 6.2 μm polycyclic aromatic hydrocarbon feature. It is found that intrinsic line widths do not change among classification for [CII], with median widths of 207 km s-1 for AGN, 248 km s-1 for composites, and 233 km s-1 for starbursts. The [NeII] line widths also do not change with classification, but [NeIII] lines are progressively broader from starburst to AGN. A small number of objects with unusually broad lines or unusual redshift differences in any feature are identified.

  13. Evolving production network structures

    DEFF Research Database (Denmark)

    Grunow, Martin; Gunther, H.O.; Burdenik, H.

    2007-01-01

    When deciding about future production network configurations, the current structures have to be taken into account. Further, core issues such as the maturity of the products and the capacity requirements for test runs and ramp-ups must be incorporated. Our approach is based on optimization...... modelling and assigns products and capacity expansions to production sites under the above constraints. It also considers the production complexity at the individual sites and the flexibility of the network. Our implementation results for a large manufacturing network reveal substantial possible cost...... reductions compared to the traditional manual planning results of our industrial partner....

  14. EVOLVE : International Conference

    CERN Document Server

    Deutz, Andre; Schuetze, Oliver; Bäck, Thomas; Tantar, Emilia; Tantar, Alexandru-Adrian; Moral, Pierre; Legrand, Pierrick; Bouvry, Pascal; Coello, Carlos

    2013-01-01

    Numerical and computational methods are nowadays used in a wide range of contexts in complex systems research, biology, physics, and engineering.  Over the last decades different methodological schools have emerged with emphasis on different aspects of computation, such as nature-inspired algorithms, set oriented numerics, probabilistic systems and Monte Carlo methods. Due to the use of different terminologies and emphasis on different aspects of algorithmic performance there is a strong need for a more integrated view and opportunities for cross-fertilization across particular disciplines. These proceedings feature 20 original publications from distinguished authors in the cross-section of computational sciences, such as machine learning algorithms and probabilistic models, complex networks and fitness landscape analysis, set oriented numerics and cell mapping, evolutionary multiobjective optimization, diversity-oriented search, and the foundations of genetic programming algorithms. By presenting cutting ed...

  15. When did oxygenic photosynthesis evolve?

    National Research Council Canada - National Science Library

    Roger Buick

    2008-01-01

    ...2.4 Ga ago, but when the photosynthetic oxygen production began is debatable. However, geological and geochemical evidence from older sedimentary rocks indicates that oxygenic photosynthesis evolved well before this oxygenation event...

  16. Neutral ISM, Ly α , and Lyman-continuum in the Nearby Starburst Haro 11

    Energy Technology Data Exchange (ETDEWEB)

    Rivera-Thorsen, T. Emil; Östlin, Göran; Hayes, Matthew; Puschnig, Johannes, E-mail: trive@astro.su.se [Department of Astronomy, Stockholm University, AlbaNova University Centre, SE-106 91 Stockholm (Sweden)

    2017-03-01

    Star-forming galaxies are believed to be a major source of Lyman continuum (LyC) radiation responsible for reionizing the early universe. Direct observations of escaping ionizing radiation have however been sparse and with low escape fractions. In the local universe, only 10 emitters have been observed, with typical escape fractions of a few percent. The mechanisms regulating this escape need to be strongly evolving with redshift in order to account for the epoch of reionization. Gas content and star formation feedback are among the main suspects, known to both regulate neutral gas coverage and evolve with cosmic time. In this paper, we reanalyze Hubble Space Telescope ( HST )-Cosmic Origins Spectrograph (COS) spectrocopy of the first detected local LyC leaker, Haro 11. We examine the connection between LyC leakage and Ly α line shape, and feedback-influenced neutral interstellar medium (ISM) properties like kinematics and gas distribution. We discuss the two extremes of an optically thin, density bounded ISM and a riddled, optically thick, ionization bounded ISM, and how Haro 11 fits into theoretical predictions. We find that the most likely ISM model is a clumpy neutral medium embedded in a highly ionized medium with a combined covering fraction of unity and a residual neutral gas column density in the ionized medium high enough to be optically thick to Ly α , but low enough to be at least partly transparent to LyC and undetected in Si ii. This suggests that star formation feedback and galaxy-scale interaction events play a major role in opening passageways for ionizing radiation through the neutral medium.

  17. Spatially resolved medium resolution spectroscopy of an interacting E+A (post-starburst) system with the Subaru Telescope

    Science.gov (United States)

    Goto, Tomotsugu; Yagi, Masafumi; Yamauchi, Chisato

    2008-12-01

    We have performed spatially resolved medium resolution long-slit spectroscopy of a nearby E+A (post-starburst) galaxy system, SDSSJ161330.18+510335.5, with the FOCAS spectrograph mounted on the Subaru Telescope. This E+A galaxy has an obvious companion galaxy 14kpc in front with the velocity difference of 61.8kms-1. Both galaxies have obviously disturbed morphology. Thus, this E+A system provides us with a perfect opportunity to investigate the relation between the post-starburst phenomena and galaxy-galaxy interaction. We have found that the Hδ equivalent width (EW) of the E+A galaxy is greater than 7Å galaxy wide (8.5kpc) with no significant spatial variation. The E+A galaxy has a weak [OIII] emission (EW ~ 1Å) offset by ~2.6kpc from the peak of the Balmer absorption lines. We detected a rotational velocity in the companion galaxy of >175kms-1. The progenitor of the companion may have been a rotationally supported, but yet passive S0 galaxy. We did not detect significant rotation on the E+A galaxy. A metallicity estimate based on the r - H colour suggests Z = 0.008 and 0.02, for the E+A and the companion galaxies, respectively. Assuming these metallicity estimates, the age of the E+A galaxy after quenching the star formation is estimated to be 100-500Myr, with its centre having a slightly younger stellar population. The companion galaxy is estimated to have an older stellar population of >2Gyr of age with no significant spatial variation. These findings are inconsistent with a simple picture where the dynamical interaction creates infall of the gas reservoir that causes the central starburst/post-starburst. Instead, our results present an important example where the galaxy-galaxy interaction can trigger a galaxy-wide post-starburst phenomenon. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. E-mail: tomo@ifa.hawaii.edu ‡ Japan Society for the Promotion of Science (JSPS) SPD Fellow.

  18. Metabolic memory: Evolving concepts.

    Science.gov (United States)

    Misra, Anoop; Bloomgarden, Zachary

    2018-03-01

    to standard control. However, the UKPDS blood pressure control trial showed a reduction in complications, but no difference between the intervention and control groups was seen during the follow-up of this portion of the study, suggesting that no such "memory" exists for these interventions. The molecular mechanisms underlying these long-term effects of prior periods of better or worse glycemic control continue to be investigated. Extended periods of exposure to high glucose levels persistently dysregulated fibrotic and inflammatory genes in endothelial and vascular smooth muscle cells. Furthermore, epigenetic processes may contribute to metabolic memory, with evidence that post-translational histone methylation and changes in microRNA may persist after exposure to high glucose levels is terminated. In this context, it is of note that the zebrafish model of T1D exhibits regeneration of the pancreas, becoming euglycemic after a period of hyperglycemia, but with evidence in this model that delay in skin wound healing persists indefinitely even after multiple rounds of fin regeneration, suggesting a long-lasting adverse effect of prior hyperglycemia. Such epigenetic differences were reported in genes related to the nuclear factor-κB inflammatory pathway and to diabetes complications in a study of intensive versus conventional treatment patients followed from the DCCT. A further mechanism that has been suggested is a role of dysregulated mitochondrial biogenesis contributing to deterioration of retinopathy even after a period of good glycemic control continues. Interestingly, in this issue of the Journal, Pantalone et al. present a study that touches upon our first question, failing to find a relationship between the HbA1c level measured at the time of diabetes diagnosis and subsequent outcome. The study analyzed relationships between glycemic control and complications among >30 000 people with newly diagnosed T2D followed for the subsequent decade. Might the level of

  19. An actively accreting massive black hole in the dwarf starburst galaxy Henize 2-10.

    Science.gov (United States)

    Reines, Amy E; Sivakoff, Gregory R; Johnson, Kelsey E; Brogan, Crystal L

    2011-02-03

    Supermassive black holes are now thought to lie at the heart of every giant galaxy with a spheroidal component, including our own Milky Way. The birth and growth of the first 'seed' black holes in the earlier Universe, however, is observationally unconstrained and we are only beginning to piece together a scenario for their subsequent evolution. Here we report that the nearby dwarf starburst galaxy Henize 2-10 (refs 5 and 6) contains a compact radio source at the dynamical centre of the galaxy that is spatially coincident with a hard X-ray source. From these observations, we conclude that Henize 2-10 harbours an actively accreting central black hole with a mass of approximately one million solar masses. This nearby dwarf galaxy, simultaneously hosting a massive black hole and an extreme burst of star formation, is analogous in many ways to galaxies in the infant Universe during the early stages of black-hole growth and galaxy mass assembly. Our results confirm that nearby star-forming dwarf galaxies can indeed form massive black holes, and that by implication so can their primordial counterparts. Moreover, the lack of a substantial spheroidal component in Henize 2-10 indicates that supermassive black-hole growth may precede the build-up of galaxy spheroids.

  20. The SDSS Discovery of a Strongly Lensed Post-Starburst Galaxy at z=0.766

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Min-Su; Strauss, Michael A.; Oguri, Masamune; Inada, Naohisa; Falco, Emilio E.; Broadhurst, Tom; Gunn, James E.

    2008-09-30

    We present the first result of a survey for strong galaxy-galaxy lenses in Sloan Digital Sky Survey (SDSS) images. SDSS J082728.70+223256.4 was selected as a lensing candidate using selection criteria based on the color and positions of objects in the SDSS photometric catalog. Follow-up imaging and spectroscopy showed this object to be a lensing system. The lensing galaxy is an elliptical at z = 0.349 in a galaxy cluster. The lensed galaxy has the spectrum of a post-starburst galaxy at z = 0.766. The lensing galaxy has an estimated mass of {approx} 1.2 x 10{sup 12} M{sub {circle_dot}} and the corresponding mass to light ratio in the B-band is {approx} 26 M{sub {circle_dot}}/L{sub {circle_dot}} inside 1.1 effective radii of the lensing galaxy. Our study shows how catalogs drawn from multi-band surveys can be used to find strong galaxy-galaxy lenses having multiple lens images. Our strong lensing candidate selection based on photometry-only catalogs will be useful in future multi-band imaging surveys such as SNAP and LSST.

  1. ALMA Maps of Dust and Warm Dense Gas Emission in the Starburst Galaxy IC 5179

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Yinghe [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Lu, Nanyao; Xu, C. Kevin [National Astronomical Observatories of China, Chinese Academy of Sciences, Beijing 100012 (China); Díaz-Santos, Tanio [Núcleo de Astronomía de la Facultad de Ingeniería, Universidad Diego Portales, Av. Ejército Libertador 441, Santiago (Chile); Gao Yu [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Charmandaris, Vassilis [Department of Physics, University of Crete, GR-71003 Heraklion (Greece); Werf, Paul van der [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA Leiden (Netherlands); Zhang Zhi-Yu [Institute for Astronomy, University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Cao, Chen, E-mail: zhaoyinghe@ynao.ac.cn [School of Space Science and Physics, Shandong University at Weihai, Weihai, Shandong 264209 (China)

    2017-08-10

    We present our high-resolution (0.″15 × 0.″13, ∼34 pc) observations of the CO (6−5) line emission, which probes the warm and dense molecular gas, and the 434 μ m dust continuum emission in the nuclear region of the starburst galaxy IC 5179, conducted with the Atacama Large Millimeter Array (ALMA). The CO (6−5) emission is spatially distributed in filamentary structures with many dense cores and shows a velocity field that is characteristic of a circumnuclear rotating gas disk, with 90% of the rotation speed arising within a radius of ≲150 pc. At the scale of our spatial resolution, the CO (6−5) and dust emission peaks do not always coincide, with their surface brightness ratio varying by a factor of ∼10. This result suggests that their excitation mechanisms are likely different, as further evidenced by the southwest to northeast spatial gradient of both CO-to-dust continuum ratio and Pa- α equivalent width. Within the nuclear region (radius ∼ 300 pc) and with a resolution of ∼34 pc, the CO line flux (dust flux density) detected in our ALMA observations is 180 ± 18 Jy km s{sup −1} (71 ± 7 mJy), which accounts for 22% (2.4%) of the total value measured by Herschel .

  2. EXTREME EMISSION-LINE GALAXIES IN CANDELS: BROADBAND-SELECTED, STARBURSTING DWARF GALAXIES AT z > 1

    Energy Technology Data Exchange (ETDEWEB)

    Van der Wel, A.; Rix, H.-W.; Jahnke, K. [Max-Planck Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Straughn, A. N. [Astrophysics Science Division, Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Finkelstein, S. L.; Salmon, B. W. [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); Koekemoer, A. M.; Ferguson, H. C. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Weiner, B. J. [Steward Observatory, 933 N. Cherry St., University of Arizona, Tucson, AZ 85721 (United States); Wuyts, S. [Max-Planck-Institut fuer Extraterrestrische Physik, Giessenbachstrasse, D-85748 Garching (Germany); Bell, E. F. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Faber, S. M.; Trump, J. R.; Koo, D. C. [UCO/Lick Observatory, Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Scarlata, C. [Minnesota Institute for Astrophysics, University of Minnesota, 116 Church St. S.E. Minneapolis, MN 55455 (United States); Hathi, N. P. [Observatories of the Carnegie Institution of Washington, Pasadena, CA 91101 (United States); Dunlop, J. S. [Institute for Astronomy, University of Edinburgh, Royal Observatory, Edinburgh EH9 3HJ (United Kingdom); Newman, J. A. [Department of Physics and Astronomy, University of Pittsburgh, 3941 O' Hara Street, Pittsburgh, PA 15260 (United States); Dickinson, M. [National Optical Astronomy Observatory, 950 North Cherry Avenue, Tucson, AZ 85719 (United States); De Mello, D. F., E-mail: vdwel@mpia.de [Department of Physics, The Catholic University of America, Washington, DC 20064 (United States); and others

    2011-12-01

    We identify an abundant population of extreme emission-line galaxies (EELGs) at redshift z {approx} 1.7 in the Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey imaging from Hubble Space Telescope/Wide Field Camera 3 (HST/WFC3). Sixty-nine EELG candidates are selected by the large contribution of exceptionally bright emission lines to their near-infrared broadband magnitudes. Supported by spectroscopic confirmation of strong [O III] emission lines-with rest-frame equivalent widths {approx}1000 A-in the four candidates that have HST/WFC3 grism observations, we conclude that these objects are galaxies with {approx}10{sup 8} M{sub Sun} in stellar mass, undergoing an enormous starburst phase with M{sub *}/ M-dot{sub *} of only {approx}15 Myr. These bursts may cause outflows that are strong enough to produce cored dark matter profiles in low-mass galaxies. The individual star formation rates and the comoving number density (3.7 Multiplication-Sign 10{sup -4} Mpc{sup -3}) can produce in {approx}4 Gyr much of the stellar mass density that is presently contained in 10{sup 8}-10{sup 9} M{sub Sun} dwarf galaxies. Therefore, our observations provide a strong indication that many or even most of the stars in present-day dwarf galaxies formed in strong, short-lived bursts, mostly at z > 1.

  3. Comment on "Sandbox modeling of evolving thrust wedges with different preexisting topographic relief: Implications for the longmen Shan thrust belt, eastern Tibet" by C. Sun et al.

    Science.gov (United States)

    Tan, Xibin; Xu, Xiwei; Lu, Renqi

    2017-02-01

    Sun et al.'s (2016) sandbox modeling takes preexisting topographic relief into account for faulting activity at the compressional orogenic belt, which promotes better understanding of Longmenshan thrust belt's (LTB) orogenic process and faulting behavior. However, topographic relief in sandbox modeling is contradictory to central LTB's actual topographic relief, and as a result, both the comparison between sandbox modeling and actual tectonics and topography and the conclusion that Xiaoyudong Fault is a tear fault should be reconsidered. Actually, based on Sun et al.'s (2016) sandbox modeling, the Xiaoyudong Fault cannot be treated as a tear fault.

  4. Neutral ISM, Lyα, and Lyman-continuum in the Nearby Starburst Haro11

    Science.gov (United States)

    Rivera-Thorsen, T. Emil; Östlin, Göran; Hayes, Matthew; Puschnig, Johannes

    2017-03-01

    Star-forming galaxies are believed to be a major source of Lyman continuum (LyC) radiation responsible for reionizing the early universe. Direct observations of escaping ionizing radiation have however been sparse and with low escape fractions. In the local universe, only 10 emitters have been observed, with typical escape fractions of a few percent. The mechanisms regulating this escape need to be strongly evolving with redshift in order to account for the epoch of reionization. Gas content and star formation feedback are among the main suspects, known to both regulate neutral gas coverage and evolve with cosmic time. In this paper, we reanalyze Hubble Space Telescope (HST)-Cosmic Origins Spectrograph (COS) spectrocopy of the first detected local LyC leaker, Haro 11. We examine the connection between LyC leakage and Lyα line shape, and feedback-influenced neutral interstellar medium (ISM) properties like kinematics and gas distribution. We discuss the two extremes of an optically thin, density bounded ISM and a riddled, optically thick, ionization bounded ISM, and how Haro 11 fits into theoretical predictions. We find that the most likely ISM model is a clumpy neutral medium embedded in a highly ionized medium with a combined covering fraction of unity and a residual neutral gas column density in the ionized medium high enough to be optically thick to Lyα, but low enough to be at least partly transparent to LyC and undetected in Si II. This suggests that star formation feedback and galaxy-scale interaction events play a major role in opening passageways for ionizing radiation through the neutral medium. Based on observations with HST-COS, program GO 13017, obtained from the Mikulski Archive for Space Telescopes (MAST). STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. Support for MAST for non-HST data is provided by the NASA Office of Space Science via grant NNX09AF08G and by other grants and

  5. Observations of the impact of starbursts on the interstellar medium in dwarf galaxies

    Science.gov (United States)

    Marlowe, Amanda T.; Heckman, Timothy M.; Wyse, Rosemary F. G.; Schommer, Robert

    1995-01-01

    Dwarf galaxies play a crucial role in our understanding of the formation and evolution of galaxies, and the concept of supernova-driven mass outflows is a vital ingredient in theories of the structure and evolution of dwarf galaxies. Despite the theoretical importance of these outflows, there is a very limited amount of direct observational evidence for their existence. We have therefore begun a detailed multi-wave-band search for outflows in dwarf (M(sub B) greater than or = -18) galaxies with extensive recent or ongoing centrally concentrated star formation. We report the first results of this search in the present paper. Observations of the ionized gas in dwarf amorphous galaxies with centrally concentrated populations of massive stars provide evidence for the large-scale expansion of their expansion of their ionized interstellar media. Fabry-Perot H alpha images reveal the presence of kiloparsec-scale 'superbubbles' and filaments which tend to be oriented along the galaxy minor axis. These structures are comparable in size to the chracteristic optical sizes of the galaxies, and dominate the morphology of the galaxies at low surface brightness in H alpha. Since expanding structure of this size and velocity are not observed in all low-mass galaxies with recent or ongoing star formation, we suggest that we are witnessing transient events that likely have a relatively low 'duty cycle' in such galaxies. That is, we argue that the particular galaxies in the present paper have had significantly elevated star formation rates over the past 10(exp 7)-10(exp 8) yr (i.e., these are starburst or young poststarburst systems). This interpretation is consistent with the optical colors and emission-line properties of these galaxies.

  6. 2D kinematical study in local luminous compact blue galaxies. Starburst origin in UCM2325+2318

    Science.gov (United States)

    Castillo-Morales, A.; Pérez-Gallego, J.; Gallego, J.; Guzmán, R.; Castander, F.; Garland, C.; Gruel, N.; Pisano, D. J.; Muñoz-Mateos, J. C.; Ocaña, F.; Zamorano, J.

    2013-05-01

    Luminous Compact Blue Galaxies (LCBGs) are small, but vigorously star forming galaxies. Their presence at different redshifts denotes their cosmological relevance and implies that local starburst galaxies, when properly selected, are unique laboratories for studying the complex ecosystem of the star formation process over time. We have selected a representative sample of 22 LCBGs from the SDSS and UCM databases which, although small, provides an excellent reference for comparison with current and future surveys of similar starbursts at high-z. We are carrying out a 2D optical spectroscopic study of this LCBG sample, including spatially resolved maps of kinematics, extinction, SFR and metallicity. This will help us to answer questions regarding the nature of these objects. In this poster we show our results on the kinematical study (Pérez-Gallego et al. 2011) which allows us to classify these galaxies into three different classes: rotating disk (RD) 48%, perturbed rotation (PR) 28% and complex kinematics (CK) 24%. We find 5% of objects show evidence of a recent major merger, 10% of a minor merger, and 45% of a companion. This argues in favor of ongoing interactions with close companions as a mechanism for the enhanced star formation activity in these galaxies. We find only 5% of objects with clear evidence of AGN activity, and 27% with kinematics consistent with SN-driven galactic winds. Therefore, a different mechanism may be responsible for quenching the star formation in LCBGs. The detailed analysis of the physical properties for each galaxy in the sample is on progress and we show in this poster the results on UCM2325+2318 as a prototype LCBG. Between the possible mechanisms to explain the starburst activity in this galaxy, our 2D spectroscopic data support the scenario of an on-going interaction with the possibility for clump B to be the dwarf satellite galaxy (Castillo-Morales et al. 2011, Pérez-Gallego et al. 2010).

  7. Fractionation and current time trends of PCB congeners: evolvement of distributions 1950–2010 studied using a global atmosphere-ocean general circulation model

    OpenAIRE

    G. Lammel; I. Stemmler

    2012-01-01

    PCBs are ubiquitous environmental pollutants expected to decline in abiotic environmental media in response to decreasing primary emissions since the 1970s. A coupled atmosphere-ocean general circulation model with embedded dynamic sub-models for atmospheric aerosols and the marine biogeochemistry and air-surface exchange processes with soils, vegetation and the cryosphere is used to study the transport and fate of four PCB congeners covering a range of 3–7 chlorine atoms.
    &...

  8. Fractionation and current time trends of PCB congeners: evolvement of distributions 1950–2010 studied using a global atmosphere-ocean general circulation model

    OpenAIRE

    G. Lammel; I. Stemmler

    2012-01-01

    PCBs are ubiquitous environmental pollutants expected to decline in abiotic environmental media in response to decreasing primary emissions since the 1970s. A coupled atmosphere-ocean general circulation model with embedded dynamic sub-models for atmospheric aerosols and the marine biogeochemistry and air-surface exchange processes with soils, vegetation and the cryosphere is used to study the transport and fate of four PCB congeners covering a range of 3–7 chlorine atoms.

  9. Carbazole end-capped and triphenylamine-centered starburst derivative for hole-transport in electroluminescent devices

    Science.gov (United States)

    Singh, Gopal; Bhalla, Vandana; Kumar, Manoj

    2015-08-01

    Carbazole end-capped and triphenylamine centered starburst derivative TPA-Cz has been synthesised. An investigation into its various properties show that the derivative possesses excellent thermal and morphological stability with stable amorphous behaviour, uniform surface morphology of film (rms roughness of 1.212 nm), low oxidation potential (-5.2 eV) along with electrochemical stability, high solubility and high transparency to visible light. All these properties clearly demonstrate that TPA-Cz is a highly promising material that can be used as hole-transporting material in the electroluminescent devices.

  10. A search for candidate radio supernova remnants in the nearby irregular starburst galaxies NGC 4214 and NGC 4395

    Directory of Open Access Journals (Sweden)

    Vukotić B.

    2005-01-01

    Full Text Available We present the results of a search for new candidate radio su­pernova remnants (SNRs in the nearby starburst irregular galaxies NGC 4214 and NGC 4395 using archived radio observations made with the Very Large Array (VLA at the wavelengths of 3.5 cm, 6 cm and 20 cm for NGC 4214 and 6 cm and 20 cm for NGC 4395. These observations were analyzed as part of our ongoing search for candidate radio SNRs in nearby galaxies: the goal of this search is to prepare a large sample of candidate radio SNRs for the purpose of a robust statistical study of the properties of these sources. Based on our analysis, we have confirmed the nonthermal nature of the discrete radio sources α and β in NGC 4214 and classify these sources as candidate radio SNRs based on their positional coincidences with HII regions in that galaxy. We have measured the flux densities of the two candidate radio SNRs at each wavelength and calculated corresponding spectral indices: we have also measured flux densities of two other discrete radio sources in these galaxies - ρ in NGC 4214 and #3 in NGC 4395 which we suspect to be additional candidate radio SNRs based on their positional coincidences with other HII regions in these galaxies. However, the radio data presently available for these sources can­not confirm such a classification and additional observations are needed. We have also calculated the radio luminosities Lradio at the wavelength of 20 cm for these two candidate radio SNRs as well as the corresponding values for the minimum total energy Emin required to power these radio sources via synchrotron emission and the corresponding magnetic field strength Bmin. We have compared our mean calculated values for these properties with the mean values for populations of candidate radio SNRs in other starburst galaxies: while the values for Lradio and Bmin are roughly comparable to the values seen in other starburst galaxies, the mean value for Emin is higher than the mean value of any

  11. Loops and autonomy promote evolvability of ecosystem networks.

    Science.gov (United States)

    Luo, Jianxi

    2014-09-29

    The structure of ecological networks, in particular food webs, determines their ability to evolve further, i.e. evolvability. The knowledge about how food web evolvability is determined by the structures of diverse ecological networks can guide human interventions purposefully to either promote or limit evolvability of ecosystems. However, the focus of prior food web studies was on stability and robustness; little is known regarding the impact of ecological network structures on their evolvability. To correlate ecosystem structure and evolvability, we adopt the NK model originally from evolutionary biology to generate and assess the ruggedness of fitness landscapes of a wide spectrum of model food webs with gradual variation in the amount of feeding loops and link density. The variation in network structures is controlled by linkage rewiring. Our results show that more feeding loops and lower trophic link density, i.e. higher autonomy of species, of food webs increase the potential for the ecosystem to generate heritable variations with improved fitness. Our findings allow the prediction of the evolvability of actual food webs according to their network structures, and provide guidance to enhancing or controlling the evolvability of specific ecosystems.

  12. Reply to comment by Tan et al. on "Sandbox modeling of evolving thrust wedges with different preexisting topographic relief: Implications for the Longmen Shan thrust belt, eastern Tibet"

    Science.gov (United States)

    Sun, Chuang; Jia, Dong; Yin, Hongwei; Chen, Zhuxin; Li, Zhigang; Li, Shen; Wei, Dongtao; Li, Yiquan; Yan, Bin; Wang, Maomao; Fang, Shaozhi; Cui, Jian

    2017-02-01

    Tan et al. comment that the preexisting topographic relief in our sandbox is opposed to its prototype in the central Longmen Shan. Therefore, the comparison between our sandbox modeling and the natural topography is questionable and does not agree with our conclusion that the Xiaoyudong fault is a tear fault. First, we are grateful to the authors for their approval of our sandbox modeling and its contribution to understanding fault behavior within thrust wedges. However, after reading the comment carefully, we found that they misunderstood the meaning of topographic relief we conveyed. In response, we would like to address the differences between the topography in their comment and the orogen-scale topography we investigated in our modeling to defend our conclusion.

  13. f( R) gravity solutions for evolving wormholes

    Science.gov (United States)

    Bhattacharya, Subhra; Chakraborty, Subenoy

    2017-08-01

    The scalar-tensor f( R) theory of gravity is considered in the framework of a simple inhomogeneous space-time model. In this research we use the reconstruction technique to look for possible evolving wormhole solutions within viable f( R) gravity formalism. These f( R) models are then constrained so that they are consistent with existing experimental data. Energy conditions related to the matter threading the wormhole are analyzed graphically and are in general found to obey the null energy conditions (NEC) in regions around the throat, while in the limit f(R)=R, NEC can be violated at large in regions around the throat.

  14. The Evolving Resource Metadata Infrastructure

    Science.gov (United States)

    Biemesderfer, Chris

    The search and discovery mechanisms that will facilitate and simplify systematic research on the Internet depend on systematic classifications of resources, as well as on standardized access to such metadata. The principles and technologies that will make this possible are evolving in the work of the Internet Engineering Task Force and the digital library initiatives, among others. The desired outcome is a set of standards, tools, and practices that permits both cataloging and retrieval to be comprehensive and efficient.

  15. Discovery of a z = 0.65 post-starburst BAL quasar in the DES supernova fields

    Energy Technology Data Exchange (ETDEWEB)

    Mudd, Dale; Martini, Paul; Tie, Suk Sien; Lidman, Chris; McMahon, Richard; Banerji, Manda; Davis, Tamara; Peterson, Bradley; Sharp, Rob; Seymour, Nicholas; Childress, Michael; Lewis, Geraint; Tucker, Brad; Yuan, Fang; Abbot, Tim; Abdalla, Filipe; Allam, Sahar; Benoit-Lévy, Aurélien; Bertin, Emmanuel; Brooks, David; Camero Rosell, A.; Carrasco Kind, Matias; Carretero, Jorge; da Costa, Luiz N.; Desai, Shantanu; Diehl, Thomas; Eifler, Tim; Finley, David; Flaugher, Brenna; Glazebrook, Karl; Gruen, Daniel; Gruendl, Robert; Gutierrez, Gaston; Hinton, Samuel; Honscheid, Klaus; James, David; Kuehn, Kyler; Kuropatkin, Nikolav; Macaulay, Edward; Maia, Marcio A. G.; Miquel, Ramon; Ogando, Ricardo; Plazas, Andres; Riel, Kevin; Sanchez, Eusebio; Santiago, Basillio; Schubnell, Michael; Sevilla-Noarbe, Ignacio; Smith, Robert C.; Soares-Santos, Marcelle; Sobreira, Flavia; Suchyta, Eric; Swanson, Molly; Tarle, Gregory; Thomas, Daniel; Uddin, Syed; Walker, Alistair; Zhang, Bonnie

    2017-03-23

    We present the discovery of a z=0.65 low-ionization broad absorption line (LoBAL) quasar in a post-starburst galaxy in data from the Dark Energy Survey (DES) and spectroscopy from the Australian Dark Energy Survey (OzDES). LoBAL quasars are a minority of all BALs, and rarer still is that this object also exhibits broad FeII (an FeLoBAL) and Balmer absorption. This is the first BAL quasar that has signatures of recently truncated star formation, which we estimate ended about 40 Myr ago. The characteristic signatures of an FeLoBAL require high column densities, which could be explained by the emergence of a young quasar from an early, dust-enshrouded phase, or by clouds compressed by a blast wave. The age of the starburst component is comparable to estimates of the lifetime of quasars, so if we assume the quasar activity is related to the truncation of the star formation, this object is better explained by the blast wave scenario.

  16. Comparing Low-Redshift Compact Dwarf Starbursts in the RESOLVE Survey with High-Redshift Blue Nuggets

    Science.gov (United States)

    Palumbo, Michael Louis; Kannappan, Sheila; Snyder, Elaine; Eckert, Kathleen; Norman, Dara; Fraga, Luciano; Quint, Bruno; Amram, Philippe; Mendes de Oliveira, Claudia; RESOLVE Team

    2018-01-01

    We identify and characterize a population of compact dwarf starburst galaxies in the RESOLVE survey, a volume-limited census of galaxies in the local universe, to probe the possibility that these galaxies are related to “blue nuggets,” a class of intensely star-forming and compact galaxies previously identified at high redshift. Blue nuggets are thought to form as the result of intense compaction events that drive fresh gas to their centers. They are expected to display prolate morphology and rotation along their minor axes. We report IFU observations of three of our compact dwarf starburst galaxies, from which we construct high-resolution velocity fields, examining the evidence for minor axis or otherwise misaligned rotation. We find multiple cases of double nuclei in our sample, which may be indicative of a merger origin as in some blue nugget formation scenarios. We compare the masses, radii, gas-to-stellar mass ratios, star formation rates, stellar surface mass densities, and environmental contexts of our sample to expectations for blue nuggets.

  17. Discovery of a z = 0.65 post-starburst BAL quasar in the DES supernova fields

    Science.gov (United States)

    Mudd, Dale; Martini, Paul; Tie, Suk Sien; Lidman, Chris; McMahon, Richard; Banerji, Manda; Davis, Tamara; Peterson, Bradley; Sharp, Rob; Seymour, Nicholas; Childress, Michael; Lewis, Geraint; Tucker, Brad; Yuan, Fang; Abbot, Tim; Abdalla, Filipe; Allam, Sahar; Benoit-Lévy, Aurélien; Bertin, Emmanuel; Brooks, David; Camero Rosell, A.; Carrasco Kind, Matias; Carretero, Jorge; da Costa, Luiz N.; Desai, Shantanu; Diehl, Thomas; Eifler, Tim; Finley, David; Flaugher, Brenna; Glazebrook, Karl; Gruen, Daniel; Gruendl, Robert; Gutierrez, Gaston; Hinton, Samuel; Honscheid, Klaus; James, David; Kuehn, Kyler; Kuropatkin, Nikolav; Macaulay, Edward; Maia, Marcio A. G.; Miquel, Ramon; Ogando, Ricardo; Plazas, Andres; Riel, Kevin; Sanchez, Eusebio; Santiago, Basillio; Schubnell, Michael; Sevilla-Noarbe, Ignacio; Smith, Robert C.; Soares-Santos, Marcelle; Sobreira, Flavia; Suchyta, Eric; Swanson, Molly; Tarle, Gregory; Thomas, Daniel; Uddin, Syed; Walker, Alistair; Zhang, Bonnie

    2017-07-01

    We present the discovery of a z = 0.65 low-ionization broad absorption line (LoBAL) quasar in a post-starburst galaxy in data from the Dark Energy Survey (DES) and spectroscopy from the Australian Dark Energy Survey (OzDES). LoBAL quasars are a minority of all BALs, and rarer still is that this object also exhibits broad Fe II (an FeLoBAL) and Balmer absorption. This is the first BAL quasar that has signatures of recently truncated star formation, which we estimate ended about 40 Myr ago. The characteristic signatures of an FeLoBAL require high column densities, which could be explained by the emergence of a young quasar from an early, dust-enshrouded phase, or by clouds compressed by a blast wave. The age of the starburst component is comparable to estimates of the lifetime of quasars, so if we assume the quasar activity is related to the truncation of the star formation, this object is better explained by the blast wave scenario.

  18. A depth-averaged debris-flow model that includes the effects of evolving dilatancy: II. Numerical predictions and experimental tests.

    Science.gov (United States)

    George, David L.; Iverson, Richard M.

    2014-01-01

    We evaluate a new depth-averaged mathematical model that is designed to simulate all stages of debris-flow motion, from initiation to deposition. A companion paper shows how the model’s five governing equations describe simultaneous evolution of flow thickness, solid volume fraction, basal pore-fluid pressure, and two components of flow momentum. Each equation contains a source term that represents the influence of state-dependent granular dilatancy. Here we recapitulate the equations and analyze their eigenstructure to show that they form a hyperbolic system with desirable stability properties. To solve the equations we use a shock-capturing numerical scheme with adaptive mesh refinement, implemented in an open-source software package we call D-Claw. As tests of D-Claw, we compare model output with results from two sets of large-scale debris-flow experiments. One set focuses on flow initiation from landslides triggered by rising pore-water pressures, and the other focuses on downstream flow dynamics, runout, and deposition. D-Claw performs well in predicting evolution of flow speeds, thicknesses, and basal pore-fluid pressures measured in each type of experiment. Computational results illustrate the critical role of dilatancy in linking coevolution of the solid volume fraction and pore-fluid pressure, which mediates basal Coulomb friction and thereby regulates debris-flow dynamics.

  19. The evolvability of programmable hardware

    Science.gov (United States)

    Raman, Karthik; Wagner, Andreas

    2011-01-01

    In biological systems, individual phenotypes are typically adopted by multiple genotypes. Examples include protein structure phenotypes, where each structure can be adopted by a myriad individual amino acid sequence genotypes. These genotypes form vast connected ‘neutral networks’ in genotype space. The size of such neutral networks endows biological systems not only with robustness to genetic change, but also with the ability to evolve a vast number of novel phenotypes that occur near any one neutral network. Whether technological systems can be designed to have similar properties is poorly understood. Here we ask this question for a class of programmable electronic circuits that compute digital logic functions. The functional flexibility of such circuits is important in many applications, including applications of evolutionary principles to circuit design. The functions they compute are at the heart of all digital computation. We explore a vast space of 1045 logic circuits (‘genotypes’) and 1019 logic functions (‘phenotypes’). We demonstrate that circuits that compute the same logic function are connected in large neutral networks that span circuit space. Their robustness or fault-tolerance varies very widely. The vicinity of each neutral network contains circuits with a broad range of novel functions. Two circuits computing different functions can usually be converted into one another via few changes in their architecture. These observations show that properties important for the evolvability of biological systems exist in a commercially important class of electronic circuitry. They also point to generic ways to generate fault-tolerant, adaptable and evolvable electronic circuitry. PMID:20534598

  20. The 'E' factor -- evolving endodontics.

    Science.gov (United States)

    Hunter, M J

    2013-03-01

    Endodontics is a constantly developing field, with new instruments, preparation techniques and sealants competing with trusted and traditional approaches to tooth restoration. Thus general dental practitioners must question and understand the significance of these developments before adopting new practices. In view of this, the aim of this article, and the associated presentation at the 2013 British Dental Conference & Exhibition, is to provide an overview of endodontic methods and constantly evolving best practice. The presentation will review current preparation techniques, comparing rotary versus reciprocation, and question current trends in restoration of the endodontically treated tooth.

  1. Density functional calculations of (55)Mn, (14)N and (13)C electron paramagnetic resonance parameters support an energetically feasible model system for the S(2) state of the oxygen-evolving complex of photosystem II.

    Science.gov (United States)

    Schinzel, Sandra; Schraut, Johannes; Arbuznikov, Alexei V; Siegbahn, Per E M; Kaupp, Martin

    2010-09-10

    Metal and ligand hyperfine couplings of a previously suggested, energetically feasible Mn(4)Ca model cluster (SG2009(-1)) for the S(2) state of the oxygen-evolving complex (OEC) of photosystem II (PSII) have been studied by broken-symmetry density functional methods and compared with other suggested structural and spectroscopic models. This was carried out explicitly for different spin-coupling patterns of the S=1/2 ground state of the Mn(III)(Mn(IV))(3) cluster. By applying spin-projection techniques and a scaling of the manganese hyperfine couplings, computation of the hyperfine and nuclear quadrupole coupling parameters allows a direct evaluation of the proposed models in comparison with data obtained from the simulation of EPR, ENDOR, and ESEEM spectra. The computation of (55)Mn hyperfine couplings (HFCs) for SG2009(-1) gives excellent agreement with experiment. However, at the current level of spin projection, the (55)Mn HFCs do not appear sufficiently accurate to distinguish between different structural models. Yet, of all the models studied, SG2009(-1) is the only one with the Mn(III) site at the Mn(C) center, which is coordinated by histidine (D1-His332). The computed histidine (14)N HFC anisotropy for SG2009(-1) gives much better agreement with ESEEM data than the other models, in which Mn(C) is an Mn(IV) site, thus supporting the validity of the model. The (13)C HFCs of various carboxylates have been compared with (13)C ENDOR data for PSII preparations with (13)C-labelled alanine.

  2. Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential Mechanism: network models, novel therapeutic target strategies, and the contributions of hypoxia, inflammation and cellular senescence.

    Science.gov (United States)

    Csermely, Peter; Hódsági, János; Korcsmáros, Tamás; Módos, Dezső; Perez-Lopez, Áron R; Szalay, Kristóf; Veres, Dániel V; Lenti, Katalin; Wu, Ling-Yun; Zhang, Xiang-Sun

    2015-02-01

    Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development. The fluctuating intensity of stress factors, like hypoxia, inflammation and the either cooperative or hostile interactions of tumor inter-cellular networks, all increase the adaptation potential of cancer cells. This may lead to the bypass of cellular senescence, and to the development of cancer stem cells. We propose that the central tenet of cancer stem cell definition lies exactly in the indefinability of cancer stem cells. Actual properties of cancer stem cells depend on the individual "stress-history" of the given tumor. Cancer stem cells are characterized by an extremely large evolvability (i.e. a capacity to generate heritable phenotypic variation), which corresponds well with the defining hallmarks of cancer stem cells: the possession of the capacity to self-renew and to repeatedly re-build the heterogeneous lineages of cancer cells that comprise a tumor in new environments. Cancer stem cells represent a cell population, which is adapted to adapt. We argue that the high evolvability of cancer stem cells is helped by their repeated transitions between plastic (proliferative, symmetrically dividing) and rigid (quiescent, asymmetrically dividing, often more invasive) phenotypes having plastic and rigid networks. Thus, cancer stem cells reverse and replay cancer development multiple times. We describe network models potentially explaining cancer stem cell-like behavior. Finally, we propose novel strategies including combination therapies and multi-target drugs to overcome the Nietzschean dilemma of cancer stem cell targeting: "what does not kill me makes me stronger". Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. (N+1)-dimensional Lorentzian evolving wormholes supported by polytropic matter

    Energy Technology Data Exchange (ETDEWEB)

    Cataldo, Mauricio [Universidad del Bio-Bio, Departamento de Fisica, Facultad de Ciencias, Concepcion (Chile); Arostica, Fernanda; Bahamonde, Sebastian [Universidad de Concepcion, Departamento de Fisica, Concepcion (Chile)

    2013-08-15

    In this paper we study (N+1)-dimensional evolving wormholes supported by energy satisfying a polytropic equation of state. The considered evolving wormhole models are described by a constant redshift function and generalizes the standard flat Friedmann-Robertson-Walker spacetime. The polytropic equation of state allows us to consider in (3+1)-dimensions generalizations of the phantom energy and the generalized Chaplygin gas sources. (orig.)

  4. Challenges on Probabilistic Modeling for Evolving Networks

    OpenAIRE

    Ding, Jianguo; Bouvry, Pascal

    2013-01-01

    With the emerging of new networks, such as wireless sensor networks, vehicle networks, P2P networks, cloud computing, mobile Internet, or social networks, the network dynamics and complexity expands from system design, hardware, software, protocols, structures, integration, evolution, application, even to business goals. Thus the dynamics and uncertainty are unavoidable characteristics, which come from the regular network evolution and unexpected hardware defects, unavoidable software errors,...

  5. Peripartum hysterectomy: an evolving picture.

    LENUS (Irish Health Repository)

    Turner, Michael J

    2012-02-01

    Peripartum hysterectomy (PH) is one of the obstetric catastrophes. Evidence is emerging that the role of PH in modern obstetrics is evolving. Improving management of postpartum hemorrhage and newer surgical techniques should decrease PH for uterine atony. Rising levels of repeat elective cesarean deliveries should decrease PH following uterine scar rupture in labor. Increasing cesarean rates, however, have led to an increase in the number of PHs for morbidly adherent placenta. In the case of uterine atony or rupture where PH is required, a subtotal PH is often sufficient. In the case of pathological placental localization involving the cervix, however, a total hysterectomy is required. Furthermore, the involvement of other pelvic structures may prospectively make the diagnosis difficult and the surgery challenging. If resources permit, PH for pathological placental localization merits a multidisciplinary approach. Despite advances in clinical practice, it is likely that peripartum hysterectomy will be more challenging for obstetricians in the future.

  6. Extreme evolved solar systems (EESS)

    Science.gov (United States)

    Gaensicke, Boris

    2017-08-01

    In just 20 years, we went from not knowing if the solar system is a fluke of Nature to realising that it is totally normal for stars to have planets. More remarkably, it is now clear that planet formation is a robust process, as rich multi-planet systems are found around stars more massive and less massive than the Sun. More recently, planetary systems have been identified in increasingly complex architectures, including circumbinary planets, wide binaries with planets orbiting one or both stellar components, and planets in triple stellar systems.We have also learned that many planetary systems will survive the evolution of their host stars into the white dwarf phase. Small bodies are scattered by unseen planets into the gravitational field of the white dwarfs, tidally disrupt, form dust discs, and eventually accrete onto the white dwarf, where they can be spectroscopically detected. HST/COS has played a critical role in the study these evolved planetary systems, demonstrating that overall the bulk composition of the debris is rocky and resembles in composition the inner the solar system, including evidence for water-rich planetesimals. Past observations of planetary systems at white dwarfs have focused on single stars with main-sequence progenitors of 1.5 to 2.5Msun. Here we propose to take the study of evolved planetary systems into the extremes of parameter ranges to answer questions such as: * How efficient is planet formation around 4-10Msun stars? * What are the metallicities of the progenitors of debris-accreting white dwarfs?* What is the fate of circumbinary planets?* Can star-planet interactions generate magnetic fields in the white dwarf host?

  7. Survivability is more fundamental than evolvability.

    Directory of Open Access Journals (Sweden)

    Michael E Palmer

    Full Text Available For a lineage to survive over long time periods, it must sometimes change. This has given rise to the term evolvability, meaning the tendency to produce adaptive variation. One lineage may be superior to another in terms of its current standing variation, or it may tend to produce more adaptive variation. However, evolutionary outcomes depend on more than standing variation and produced adaptive variation: deleterious variation also matters. Evolvability, as most commonly interpreted, is not predictive of evolutionary outcomes. Here, we define a predictive measure of the evolutionary success of a lineage that we call the k-survivability, defined as the probability that the lineage avoids extinction for k generations. We estimate the k-survivability using multiple experimental replicates. Because we measure evolutionary outcomes, the initial standing variation, the full spectrum of generated variation, and the heritability of that variation are all incorporated. Survivability also accounts for the decreased joint likelihood of extinction of sub-lineages when they 1 disperse in space, or 2 diversify in lifestyle. We illustrate measurement of survivability with in silico models, and suggest that it may also be measured in vivo using multiple longitudinal replicates. The k-survivability is a metric that enables the quantitative study of, for example, the evolution of 1 mutation rates, 2 dispersal mechanisms, 3 the genotype-phenotype map, and 4 sexual reproduction, in temporally and spatially fluctuating environments. Although these disparate phenomena evolve by well-understood microevolutionary rules, they are also subject to the macroevolutionary constraint of long-term survivability.

  8. The Circumnuclear Environment of IRAS 20551-4250: A Case Study of AGN/Starburst Connection for JWST

    Directory of Open Access Journals (Sweden)

    E. Sani

    2012-01-01

    Full Text Available We present a general review of the current knowledge of IRAS 20551-4250 and its circumnuclear environment. This Ultraluminous Infrared Galaxy is one of the most puzzling sources of its class in the nearby Universe: the near-IR spectrum is typical of a galaxy experiencing a very intense starburst, but a highly obscured active nucleus is identified beyond ~5 μm and possibly dominates the mid-IR energy output of the system. At longer wavelengths star formation is again the main driver of the global spectral shape and features. We interpret all the available IR diagnostics in the framework of simultaneous black hole growth and star formation and discuss the key properties that make this source an ideal laboratory for the forthcoming James Webb Space Telescope.

  9. Planck's dusty GEMS. IV. Star formation and feedback in a maximum starburst at z = 3 seen at 60-pc resolution

    Science.gov (United States)

    Cañameras, R.; Nesvadba, N.; Kneissl, R.; Frye, B.; Gavazzi, R.; Koenig, S.; Le Floc'h, E.; Limousin, M.; Oteo, I.; Scott, D.

    2017-08-01

    We present an analysis of high-resolution ALMA interferometry of CO(4-3) line emission and dust continuum in the "Ruby" (PLCK_G244.8+54.9), a bright, gravitationally lensed galaxy at z = 3.0 discovered with the Planck all-sky survey. The Ruby is the brightest of Planck's dusty GEMS, a sample of 11 of the brightest gravitationally lensed high-redshift galaxies on the extragalactic sub-mm sky. We resolve the high-surface-brightness continuum and CO line emission of the Ruby in several extended clumps along a partial, nearly circular Einstein ring with 1.4'' diameter around a massive galaxy at z = 1.5. Local star-formation intensities are up to 2000 M⊙ yr-1 kpc-2, amongst the highest observed at high redshift, and clearly in the range of maximal starbursts. Gas-mass surface densities are a few × 104M⊙ pc-2. The Ruby lies at, and in part even above, the starburst sequence in the Schmidt-Kennicutt diagram, and at the limit expected for star formation that is self-regulated through the kinetic energy injection from radiation pressure, stellar winds, and supernovae. We show that these processes can also inject sufficient kinetic energy and momentum into the gas to explain the turbulent line widths, which are consistent with marginally gravitationally bound molecular clouds embedded in a critically Toomre-stable disk. The star-formation efficiency is in the range 1-10% per free-fall time, consistent with the notion that the pressure balance that sets the local star-formation law in the Milky Way may well be universal out to the highest star-formation intensities. AGN feedback is not necessary to regulate the star formation in the Ruby, in agreement with the absence of a bright AGN component in the infrared and radio regimes. Based on ALMA data obtained with program 2015.1.01518.S.

  10. 3D-HST GRISM SPECTROSCOPY OF A GRAVITATIONALLY LENSED, LOW-METALLICITY STARBURST GALAXY AT z = 1.847

    Energy Technology Data Exchange (ETDEWEB)

    Brammer, Gabriel B.; Sanchez-Janssen, Ruben [European Southern Observatory, Alonso de Cordova 3107, Casilla 19001, Vitacura, Santiago (Chile); Labbe, Ivo; Franx, Marijn; Fumagalli, Mattia; Patel, Shannon [Leiden Observatory, Leiden University, 2300-RA Leiden (Netherlands); Da Cunha, Elisabete; Rix, Hans-Walter; Schmidt, Kasper B.; Van der Wel, Arjen [Max Planck Institute for Astronomy (MPIA), Koenigstuhl 17, D-69117 Heidelberg (Germany); Erb, Dawn K. [Department of Physics, University of Wisconsin-Milwaukee, P.O. Box 413, Milwaukee, WI 53201 (United States); Lundgren, Britt; Momcheva, Ivelina; Nelson, Erica; Skelton, Rosalind E.; Van Dokkum, Pieter G.; Wake, David A.; Whitaker, Katherine E. [Department of Astronomy, Yale University, New Haven, CT 06520 (United States); Marchesini, Danilo [Physics and Astronomy Department, Tufts University, Robinson Hall, Room 257, Medford, MA 02155 (United States); Quadri, Ryan, E-mail: gbrammer@eso.org [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

    2012-10-10

    We present Hubble Space Telescope (HST) imaging and spectroscopy of the gravitational lens SL2SJ02176-0513, a cusp arc at z = 1.847. The UV continuum of the lensed galaxy is very blue, which is seemingly at odds with its redder optical colors. The 3D-HST WFC3/G141 near-infrared spectrum of the lens reveals the source of this discrepancy to be extremely strong [O III] {lambda}5007 and H{beta} emission lines with rest-frame equivalent widths of 2000 {+-} 100 and 520 {+-} 40 A, respectively. The source has a stellar mass {approx}10{sup 8} M{sub Sun }, sSFR {approx} 100 Gyr{sup -1}, and detection of [O III] {lambda}4363 yields a metallicity of 12 + log (O/H) = 7.5 {+-} 0.2. We identify local blue compact dwarf analogs to SL2SJ02176-0513, which are among the most metal-poor galaxies in the Sloan Digital Sky Survey. The local analogs resemble the lensed galaxy in many ways, including UV/optical spectral energy distribution, spatial morphology, and emission line equivalent widths and ratios. Common to SL2SJ02176-0513 and its local counterparts is an upturn at mid-IR wavelengths likely arising from hot dust heated by starbursts. The emission lines of SL2SJ02176-0513 are spatially resolved owing to the combination of the lens and the high spatial resolution of HST. The lensed galaxy is composed of two clumps with combined size r{sub e} {approx}300 pc, and we resolve significant differences in UV color and emission line equivalent width between them. Though it has characteristics occasionally attributed to active galactic nuclei, we conclude that SL2SJ02176-0513 is a low-metallicity star-bursting dwarf galaxy. Such galaxies will be found in significant numbers in the full 3D-HST grism survey.

  11. Evolving MEMS Resonator Designs for Fabrication

    Science.gov (United States)

    Hornby, Gregory S.; Kraus, William F.; Lohn, Jason D.

    2008-01-01

    Because of their small size and high reliability, microelectromechanical (MEMS) devices have the potential to revolution many areas of engineering. As with conventionally-sized engineering design, there is likely to be a demand for the automated design of MEMS devices. This paper describes our current status as we progress toward our ultimate goal of using an evolutionary algorithm and a generative representation to produce designs of a MEMS device and successfully demonstrate its transfer to an actual chip. To produce designs that are likely to transfer to reality, we present two ways to modify evaluation of designs. The first is to add location noise, differences between the actual dimensions of the design and the design blueprint, which is a technique we have used for our work in evolving antennas and robots. The second method is to add prestress to model the warping that occurs during the extreme heat of fabrication. In future we expect to fabricate and test some MEMS resonators that are evolved in this way.

  12. Solid-State 55Mn NMR Spectroscopy of bis(μ-oxo)dimanganese(IV) [Mn2O2(salpn)2], a Model for the Oxygen Evolving Complex in Photosystem II

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Paul D.; Sears, Jesse A.; Yang, Ping; Dupuis, Michel; Boron, Ted; Pecoraro, Vince; Stich, Troy; Britt, R. David; Lipton, Andrew S.

    2010-12-01

    Given the obvious global energy needs, it has become imperative to develop a catalytic process for converting water to molecular oxygen and protons. Many have sought to understand the details of photosynthesis and in particular the water splitting reaction to help in the development of the appropriate catalysis.1-3 While the scientific community has made great strides towards this goal, it has fallen short at the critical stage of the determination of the structure associated with the oxygen evolving complex (OEC) within photosystem II (PSII).4,5 Despite the existence of x-ray structures of PSII,6-8 the best data we have for the structure of the OEC comes from models derived from EPR and EXAFS measurements.9-14 This experimental situation has led to collaborations with theoreticians to enable the development of models for the structure of the OEC where the experimental observables (EXAFS and magnetic resonance parameters) serve as constraints to the theoretical calculations. Of particular interest to this study is the observation of the S1 state of the Kok cycle15 where the core of the OEC can be described as a tetranuclear manganese cluster composed of Mn4OxCa. The simplest model for the OEC can be thought of as two Mn-pairs and a Ca2+ where each Mn-pair is antiferromagnetically coupled to its partner. We utilize the term "pair" to describe the Mn atoms within the OEC with the same oxidation state, which for the S1 state is (Mn2(III, III) and Mn2(IV, IV)).16 It is unclear as to the degree of interaction between the pairs as well as the role of the Ca2+. At cryogenic temperatures the S1 state of the OEC is diamagnetic and in principle amenable to solid-state NMR experiments.

  13. CERN internal communication is evolving

    CERN Multimedia

    2016-01-01

    CERN news will now be regularly updated on the CERN People page (see here).      Dear readers, All over the world, communication is becoming increasingly instantaneous, with news published in real time on websites and social networks. In order to keep pace with these changes, CERN's internal communication is evolving too. From now on, you will be informed of what’s happening at CERN more often via the “CERN people” page, which will frequently be updated with news. The Bulletin is following this trend too: twice a month, we will compile the most important articles published on the CERN site, with a brand-new layout. You will receive an e-mail every two weeks as soon as this new form of the Bulletin is available. If you have interesting news or stories to share, tell us about them through the form at: https://communications.web.cern.ch/got-story-cern-website​. You can also find out about news from CERN in real time...

  14. Tracking correlated, simultaneously evolving target populations, II

    Science.gov (United States)

    Mahler, Ronald

    2017-05-01

    This paper is the sixth in a series aimed at weakening the independence assumptions that are typically presumed in multitarget tracking. Earlier papers investigated Bayes …lters that propagate the correlations between two evolving multitarget systems. Last year at this conference we attempted to derive PHD …lter-type approximations that account for both spatial correlation and cardinality correlation (i.e., correlation between the target numbers of the two systems). Unfortunately, this approach required heuristic models of both clutter and target appearance in order to incorporate both spatial and cardinality correlation. This paper describes a fully rigorous approach- provided, however, that spatial correlation between the two populations is ignored and only their cardinality correlations are taken into account. We derive the time-update and measurement-update equations for a CPHD …lter describing the evolution of such correlated multitarget populations.

  15. Epidemic spreading on evolving signed networks

    CERN Document Server

    Saeedian, M; Jafari, G R; Kertesz, J

    2016-01-01

    Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences peoples willingness to contact others: A friendly contact may be turned to unfriendly to avoid infection. We study the susceptible-infected (SI) disease spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heiders theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms. However, the danger of infection affects the evolution of its edge signs. To describe the coupled problem of the sign evolution and disease spreading, we generalize the notion of structural balance by taking into account the state of the nodes. We introduce an energy function and carry out Monte-Carlo simulations on complete networks to test the energy landscape, where we find loc...

  16. Star formation rates from [C II] 158 μm and mid-infrared emission lines for starbursts and active galactic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Sargsyan, L.; Lebouteiller, V.; Weedman, D.; Barry, D.; Spoon, H. [Center for Radiophysics and Space Research, Cornell University, Ithaca, NY 14853 (United States); Samsonyan, A. [Byurakan Astrophysical Observatory, Byurakan 0213 (Armenia); Bernard-Salas, J. [Department of Physical Sciences, Open University, Milton Keynes MK7 6AA (United Kingdom); Houck, J., E-mail: sargsyan@isc.astro.cornell.edu, E-mail: dweedman@isc.astro.cornell.edu [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States)

    2014-07-20

    A summary is presented for 130 galaxies observed with the Herschel Photodetector Array Camera and Spectrometer instrument to measure fluxes for the [C II] 158 μm emission line. Sources cover a wide range of active galactic nucleus to starburst classifications, as derived from polycyclic aromatic hydrocarbon strength measured with the Spitzer Infrared Spectrograph. Redshifts from [C II] and line to continuum strengths (equivalent width (EW) of [C II]) are given for the full sample, which includes 18 new [C II] flux measures. Calibration of L([C II)]) as a star formation rate (SFR) indicator is determined by comparing [C II] luminosities with mid-infrared [Ne II] and [Ne III] emission line luminosities; this gives the same result as determining SFR using bolometric luminosities of reradiating dust from starbursts: log SFR = log L([C II)]) – 7.0, for SFR in M{sub ☉} yr{sup –1} and L([C II]) in L{sub ☉}. We conclude that L([C II]) can be used to measure SFR in any source to a precision of ∼50%, even if total source luminosities are dominated by an active galactic nucleus (AGN) component. The line to continuum ratio at 158 μm, EW([C II]), is not significantly greater for starbursts (median EW([C II]) = 1.0 μm) compared to composites and AGNs (median EW([C II]) = 0.7 μm), showing that the far-infrared continuum at 158 μm scales with [C II] regardless of classification. This indicates that the continuum at 158 μm also arises primarily from the starburst component within any source, giving log SFR = log νL{sub ν}(158 μm) – 42.8 for SFR in M{sub ☉} yr{sup –1} and νL{sub ν}(158 μm) in erg s{sup –1}.

  17. Star-burst 1H-pyrazolo[3,4-b]quinoline as chromophore for light emitting diodes and photovoltaic devices

    OpenAIRE

    Kityk, Iwan V.; Gondek, Ewa; Danel, Andrzej

    2010-01-01

    Abstract The current-voltage and electroluminescent features of the novel star-burst 1H-pyrazolo[3,4-b]quinoline chromophore have shown their potential applications as materials for light emitting diodes. The electroluminescence covers the white light spectral range from 420 nm up to 610 nm and achieves maximal value about 18 Cd/m2 at biased voltage 23 V. (Kityk, Iwan V.) (Gondek, Ewa) (Danel, Andrzej) ...

  18. Ground based THz Spectroscopy of Obscured Starbursts in the Early Universe enabled by the 2nd generation Redshift (z) & Early Universe Spectrometer (ZEUS-2)

    Science.gov (United States)

    Vishwas, Amit; Stacey, Gordon; Nikola, Thomas; Ferkinhoff, Carl; Parshley, Stephen; Schoenwald, Justin; Lamarche, Cody James; Higdon, James; Higdon, Sarah; Brisbin, Drew; Güesten, Rolf; Weiss, Axel; Menten, Karl; Irwin, Kent; Cho, Hsiao-Mei; Niemack, Michael; Hilton, Gene; Hubmayr, Johannes; Amiri, Mandana; Halpern, Mark; Wiebe, Donald; Hasselfield, Matthew; Ade, Peter; Tucker, Carole

    2018-01-01

    Galaxies were surprisingly dusty in the early Universe, with more than half of the light emitted from stars being absorbed by dust within the system and re-radiated into far infrared (FIR, ~50-150μm) wavelengths. Dusty star forming galaxies (DSFGs) dominate the co-moving star formation rate density of the Universe that peaks around redshift, z~2, making it compelling to study them in rest frame FIR bands. From galaxies at z > 1, the FIR line emission from abundant ions like [O III], [C II] and [N II], are redshifted into the short sub-mm telluric windows. My thesis work is based on building and deploying the 2nd Generation Redshift (z) and Early Universe Spectrometer (ZEUS-2), a long-slit, echelle grating spectrometer optimized to study broad (Δv = 300km/s) spectral lines from galaxies in the 200-650µm telluric windows using TES bolometers. These far-IR lines being extinction free and major coolants of the gas heated by (young) massive stars, are powerful probes of the physical conditions of the gas and the stellar radiation field. I present results from our survey of the [O III] 88µm line in galaxies at redshift, z ~ 2.8 to 4.6, with ZEUS-2 at the Atacama Pathfinder Experiment (APEX) Telescope. To interpret our observations along with ancillary data from optical to radio facilities, we apply photoionization models for HII regions and Photo Dissociation Region (PDR) models and confirm that the galaxies host substantial ongoing obscured star formation. The presence of doubly ionized oxygen suggests hard radiation fields and hence, elevated ionization parameters that can only be accounted for by a large population of massive stars formed during the ongoing starburst, that contribute a large fraction of the infrared luminosity. This study highlights the use of FIR line emission to trace the assembly of current day massive galaxies, conditions of star formation and details of their stellar populations. The construction and operation of ZEUS-2 were funded by NSF ATI

  19. DNA evolved to minimize frameshift mutations

    OpenAIRE

    Agoni, Valentina

    2013-01-01

    Point mutations can surely be dangerous but what is worst than to lose the reading frame?! Does DNA evolved a strategy to try to limit frameshift mutations?! Here we investigate if DNA sequences effectively evolved a system to minimize frameshift mutations analyzing the transcripts of proteins with high molecular weights.

  20. Intelligent reservoir operation system based on evolving artificial neural networks

    Science.gov (United States)

    Chaves, Paulo; Chang, Fi-John

    2008-06-01

    We propose a novel intelligent reservoir operation system based on an evolving artificial neural network (ANN). Evolving means the parameters of the ANN model are identified by the GA evolutionary optimization technique. Accordingly, the ANN model should represent the operational strategies of reservoir operation. The main advantages of the Evolving ANN Intelligent System (ENNIS) are as follows: (i) only a small number of parameters to be optimized even for long optimization horizons, (ii) easy to handle multiple decision variables, and (iii) the straightforward combination of the operation model with other prediction models. The developed intelligent system was applied to the operation of the Shihmen Reservoir in North Taiwan, to investigate its applicability and practicability. The proposed method is first built to a simple formulation for the operation of the Shihmen Reservoir, with single objective and single decision. Its results were compared to those obtained by dynamic programming. The constructed network proved to be a good operational strategy. The method was then built and applied to the reservoir with multiple (five) decision variables. The results demonstrated that the developed evolving neural networks improved the operation performance of the reservoir when compared to its current operational strategy. The system was capable of successfully simultaneously handling various decision variables and provided reasonable and suitable decisions.

  1. Evolving user needs and late-mover advantage

    NARCIS (Netherlands)

    Querbes, Adrien; Frenken, Koen

    2017-01-01

    We propose a generalized NK-model of late-mover advantage where late-mover firms leapfrog first-mover firms as user needs evolve over time. First movers face severe trade-offs between the provision of functionalities in which their products already excel and the additional functionalities requested

  2. Active Printed Materials for Complex Self-Evolving Deformations

    Science.gov (United States)

    Raviv, Dan; Zhao, Wei; McKnelly, Carrie; Papadopoulou, Athina; Kadambi, Achuta; Shi, Boxin; Hirsch, Shai; Dikovsky, Daniel; Zyracki, Michael; Olguin, Carlos; Raskar, Ramesh; Tibbits, Skylar

    2014-12-01

    We propose a new design of complex self-evolving structures that vary over time due to environmental interaction. In conventional 3D printing systems, materials are meant to be stable rather than active and fabricated models are designed and printed as static objects. Here, we introduce a novel approach for simulating and fabricating self-evolving structures that transform into a predetermined shape, changing property and function after fabrication. The new locally coordinated bending primitives combine into a single system, allowing for a global deformation which can stretch, fold and bend given environmental stimulus.

  3. Interfacial exciplex electroluminescence between diamine derivatives with starburst molecular structure and tris(acetylacetonato)-(mono-phenothroline) thulium

    Energy Technology Data Exchange (ETDEWEB)

    He Hong [Key Laboratory of Excited State Processes, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); Li Wenlian [Key Laboratory of Excited State Processes, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China)], E-mail: wllioel@yahoo.com.cn; Su Zisheng; Chu Bei; Bi Defeng; Chen Yiren; Wang Dan; Su Wenming; Li Bin [Key Laboratory of Excited State Processes, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China)

    2009-02-20

    The authors demonstrate the interfacial exciplex electroluminescence (EL) between tris(acetylacetonato)-(mono-phenothroline) thulium [Tm(AcA){sub 3}phen] and two diamine derivatives with starburst molecular structure- 4,4',4''-tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA) and 4,4',4''-tris[3-methyl-pheny(phenyl)-amino]triphenyl-amine (m-MTDATA), both of which have the same ionization potential (IP) (approximately 5.1 eV). When the Tm-complex and the two diamine derivatives are respectively used as the electron accepter and donors, the two EL devices exhibit different exciplex emissions, which verifies our previously reported opinion regarding the effect of the different substitutes on exciplex emission [W.M. Su, W.L. Li, Q. Xin, Z.S. Su, B. Chu, D.F. Bi, H. He, J.H. Niu, Appl. Phys. Lett. 91 (2007) 043508]. When the mixture of the two diamine derivatives is used as a donor, a white EL device with the Commission International de l'Eclairage (CIE) coordinates of (0.277, 0.323) is achieved. The exciplex formation mechanisms of the devices with the two different donors are discussed.

  4. Extreme Emission Line Galaxies in CANDELS: Broad-Band Selected, Star-Bursting Dwarf Galaxies at Z greater than 1

    Science.gov (United States)

    vanderWel, A.; Straughn, A. N.; Rix, H.-W.; Finkelstein, S. L.; Koekemoer, A. M.; Weiner, B. J.; Wuyts, S.; Bell, E. F.; Faber, S. M.; Trump, J. R.; hide

    2012-01-01

    We identify an abundant population of extreme emission line galaxies (EELGs) at redshift z approx. 1.7 in the Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS) imaging from Hubble Space Telescope/Wide Field Camera 3 (HST/WFC3). 69 EELG candidates are selected by the large contribution of exceptionally bright emission lines to their near-infrared broad-band magnitudes. Supported by spectroscopic confirmation of strong [OIII] emission lines . with rest-frame equivalent widths approx. 1000A in the four candidates that have HST/WFC3 grism observations, we conclude that these objects are galaxies with approx.10(exp 8) Solar Mass in stellar mass, undergoing an enormous starburst phase with M*/M* of only approx. 15 Myr. These bursts may cause outflows that are strong enough to produce cored dark matter profiles in low-mass galaxies. The individual star formation rates and the co-moving number density (3.7x10(exp -4) Mpc(sup -3) can produce in approx.4 Gyr much of the stellar mass density that is presently contained in 10(exp 8) - 10(exp 9) Solar Mass dwarf galaxies. Therefore, our observations provide a strong indication that many or even most of the stars in present-day dwarf galaxies formed in strong, short-lived bursts, mostly at z > 1.

  5. Synthesis of Evolving Cells for Reconfigurable Manufacturing Systems

    Science.gov (United States)

    Padayachee, J.; Bright, G.

    2014-07-01

    The concept of Reconfigurable Manufacturing Systems (RMSs) was formulated due to the global necessity for production systems that are able to economically evolve according to changes in markets and products. Technologies and design methods are under development to enable RMSs to exhibit transformable system layouts, reconfigurable processes, cells and machines. Existing factory design methods and software have not yet advanced to include reconfigurable manufacturing concepts. This paper presents the underlying group technology framework for the design of manufacturing cells that are able to evolve according to a changing product mix by mechanisms of reconfiguration. The framework is based on a Norton- Bass forecast and time variant BOM models. An adaptation of legacy group technology methods is presented for the synthesis of evolving cells and two optimization problems are presented within this context.

  6. Computational Genetic Regulatory Networks Evolvable, Self-organizing Systems

    CERN Document Server

    Knabe, Johannes F

    2013-01-01

    Genetic Regulatory Networks (GRNs) in biological organisms are primary engines for cells to enact their engagements with environments, via incessant, continually active coupling. In differentiated multicellular organisms, tremendous complexity has arisen in the course of evolution of life on earth. Engineering and science have so far achieved no working system that can compare with this complexity, depth and scope of organization. Abstracting the dynamics of genetic regulatory control to a computational framework in which artificial GRNs in artificial simulated cells differentiate while connected in a changing topology, it is possible to apply Darwinian evolution in silico to study the capacity of such developmental/differentiated GRNs to evolve. In this volume an evolutionary GRN paradigm is investigated for its evolvability and robustness in models of biological clocks, in simple differentiated multicellularity, and in evolving artificial developing 'organisms' which grow and express an ontogeny starting fr...

  7. Cassini Radar at Titan : Evolving Studies of an Evolving World

    Science.gov (United States)

    Lorenz, Ralph D.

    2013-04-01

    The Cassini RADAR investigation continues to explore Titan : here I summarize some recent and ongoing developments. Geological interpretation of SAR imaging engages a wide community, in particular addressing Titan's dunes, lakes, seas and fluvial systems, impact craters and possible cryovolcanic features. Mapping of these features continues to suggest a dynamic world, with geologically-recent surface change due to tectonic, hydrological and aeolian processes. Mapping of fluvial channels and shoreline features suggests some tectonic controls and spatially-variable land/sea level changes. A despeckle filter applied to the images has proven popular for image interpretation, for example in resolving what may be star- and barchanoid dune morphologies which contrast with the dominant linear type. New observations in 2012 (T83, T84 and T86) place bounds on liquid accumulation in the northern polar regions - not expected to be substantial for another couple of years - and have highlighted a possibly cryomagma-inflated 'hot cross bun' feature and anomalous midlatitude ridges that may be paleodunes from a different climate epoch. The accumulating body of topographic data from altimetry and SARtopo has permitted the assembly of a global topographic map (albeit substantially interpolated) and an estimate of the spherical harmonic shape out to degree ~12. These datasets will be of substantial value in interpreting Titan's structure and geology, and as a boundary condition on global circulation models and fluvial studies. The growing number of overlap regions also permits stereo topography on smaller scales (e.g. of impact structures Ksa and Soi) which helps to understand the processes obliterating craters on Titan.

  8. A Reaction-Diffusion Model of Cholinergic Retinal Waves

    Science.gov (United States)

    Lansdell, Benjamin; Ford, Kevin; Kutz, J. Nathan

    2014-01-01

    Prior to receiving visual stimuli, spontaneous, correlated activity in the retina, called retinal waves, drives activity-dependent developmental programs. Early-stage waves mediated by acetylcholine (ACh) manifest as slow, spreading bursts of action potentials. They are believed to be initiated by the spontaneous firing of Starburst Amacrine Cells (SACs), whose dense, recurrent connectivity then propagates this activity laterally. Their inter-wave interval and shifting wave boundaries are the result of the slow after-hyperpolarization of the SACs creating an evolving mosaic of recruitable and refractory cells, which can and cannot participate in waves, respectively. Recent evidence suggests that cholinergic waves may be modulated by the extracellular concentration of ACh. Here, we construct a simplified, biophysically consistent, reaction-diffusion model of cholinergic retinal waves capable of recapitulating wave dynamics observed in mice retina recordings. The dense, recurrent connectivity of SACs is modeled through local, excitatory coupling occurring via the volume release and diffusion of ACh. In addition to simulation, we are thus able to use non-linear wave theory to connect wave features to underlying physiological parameters, making the model useful in determining appropriate pharmacological manipulations to experimentally produce waves of a prescribed spatiotemporal character. The model is used to determine how ACh mediated connectivity may modulate wave activity, and how parameters such as the spontaneous activation rate and sAHP refractory period contribute to critical wave size variability. PMID:25474327

  9. Evolving Concepts in Lung Carcinogenesis

    Science.gov (United States)

    Gomperts, Brigitte N.; Spira, Avrum; Massion, Pierre P.; Walser, Tonya C.; Wistuba, Ignacio I.; Minna, John D.; Dubinett, Steven M.

    2012-01-01

    Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the “field of cancerization,” and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer. PMID:21500122

  10. Engineering Therapies that Evolve to Autonomously Control Epidemics

    Science.gov (United States)

    2017-06-01

    FINAL TECHNICAL REPORT Grant No. D15AP00024 “ Engineering Therapies that Evolve to Autonomously Control Epidemics” PI: Leor Weinberger...viruses could be engineered into therapeutics, known as Therapeutic Interfering Particles (’TIPs’), using the virus HIV as a model system. By engineering ... engineered TIPs could have indefinite, population-scale impact. To achieve this aim, we developed novel multi-scale models that connected the measured

  11. Epidemic spreading on evolving signed networks

    Science.gov (United States)

    Saeedian, M.; Azimi-Tafreshi, N.; Jafari, G. R.; Kertesz, J.

    2017-02-01

    Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences people's willingness to contact others: A "friendly" contact may be turned to "unfriendly" to avoid infection. We study the susceptible-infected disease-spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heider's theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms. However, the danger of infection affects the evolution of its edge signs. To describe the coupled problem of the sign evolution and disease spreading, we generalize the notion of structural balance by taking into account the state of the nodes. We introduce an energy function and carry out Monte Carlo simulations on complete networks to test the energy landscape, where we find local minima corresponding to the so-called jammed states. We study the effect of the ratio of initial friendly to unfriendly connections on the propagation of disease. The steady state can be balanced or a jammed state such that a coexistence occurs between susceptible and infected nodes in the system.

  12. WSC-07: Evolving the Web Services Challenge

    NARCIS (Netherlands)

    Blake, M. Brian; Cheung, William K.W.; Jaeger, Michael C.; Wombacher, Andreas

    Service-oriented architecture (SOA) is an evolving architectural paradigm where businesses can expose their capabilities as modular, network-accessible software services. By decomposing capabilities into modular services, organizations can share their offerings at multiple levels of granularity

  13. Satcom access in the evolved packet core

    NARCIS (Netherlands)

    Cano, M.D.; Norp, A.H.J.; Popova, M.P.

    2012-01-01

    Satellite communications (Satcom) networks are increasingly integrating with terrestrial communications networks, namely Next Generation Networks (NGN). In the area of NGN the Evolved Packet Core (EPC) is a new network architecture that can support multiple access technologies. When Satcom is

  14. Acquisition: Acquisition of the Evolved SEASPARROW Missile

    National Research Council Canada - National Science Library

    2002-01-01

    .... The Evolved SEASPARROW Missile, a Navy Acquisition Category II program, is an improved version of the RIM-7P SEASPARROW missile that will intercept high-speed maneuvering, anti-ship cruise missiles...

  15. Cyberspace Operations: Influence Upon Evolving War Theory

    Science.gov (United States)

    2011-03-18

    St ra te gy R es ea rc h Pr oj ec t CYBERSPACE OPERATIONS: INFLUENCE UPON EVOLVING WAR THEORY BY COLONEL KRISTIN BAKER United States...DATES COVERED (From - To) 4. TITLE AND SUBTITLE Cyberspace Operations: Influence Upon Evolving War Theory 5a. CONTRACT NUMBER... Leadership 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S

  16. Evolving effective incremental SAT solvers with GP

    OpenAIRE

    Bader, Mohamed; Poli, R.

    2008-01-01

    Hyper-Heuristics could simply be defined as heuristics to choose other heuristics, and it is a way of combining existing heuristics to generate new ones. In a Hyper-Heuristic framework, the framework is used for evolving effective incremental (Inc*) solvers for SAT. We test the evolved heuristics (IncHH) against other known local search heuristics on a variety of benchmark SAT problems.

  17. The Optical Structure of the Starburst Galaxy M82. I. Dynamics of the Disk and Inner-Wind

    Science.gov (United States)

    Westmoquette, M. S.; Smith, L. J.; Gallagher, J. S., III; Trancho, G.; Bastian, N.; Konstantopoulos, I. S.

    2009-05-01

    We present Gemini-North GMOS-IFU observations of the central starburst clumps and inner wind of M82, together with WIYN DensePak IFU observations of the inner 2 × 0.9 kpc of the disk. These cover the emission lines of Hα, [N II], [S II], and [S III] at a spectral resolution of 45-80 km s-1. The high signal-to-noise of the data is sufficient to accurately decompose the emission line profiles into multiple narrow components (FWHM ~ 30-130 km s-1) superimposed on a broad (FWHM ~ 150-350 km s-1) feature. This paper is the first of a series examining the optical structure of M82's disk and inner wind; here we focus on the ionized gaseous and stellar dynamics and present maps of the relevant emission line properties. Our observations show that ionized gas in the starburst core of M82 is dynamically complex with many overlapping expanding structures located at different radii. Localised line splitting of up to 100 km s-1 in the narrow component is associated with expanding shells of compressed, cool, photoionized gas at the roots of the superwind outflow. We have been able to associate some of this inner-wind gas with a distinct outflow channel characterised by its dynamics and gas density patterns, and we discuss the consequences of this discovery in terms of the developing wind outflow. The broad optical emission line component is observed to become increasingly important moving outward along the outflow channel, and in general with increasing height above/below the plane. Following our recent work on the origins of this component, we associate it with turbulent gas in wind-clump interface layers and hence sites of mass loading, meaning that the turbulent mixing of cooler gas into the outflowing hot gas must become increasingly important with height, and provides powerful direct evidence for the existence of mass-loading over a large, spatially extended area reaching far into the inner wind. We discuss the consequences and implications of this. We confirm that the

  18. SPT0346-52: NEGLIGIBLE AGN ACTIVITY IN A COMPACT, HYPER-STARBURST GALAXY AT z = 5.7

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Jingzhe; Gonzalez, Anthony H. [Department of Astronomy, University of Florida, Gainesville, FL 32611 (United States); Vieira, J. D.; Sreevani, J. [Department of Astronomy and Department of Physics, University of Illinois, 1002 West Green St., Urbana, IL 61801 (United States); Aravena, M. [Núcleo de Astronomía, Facultad de Ingeniería, Universidad Diego Portales, Av. Ejército 441, Santiago (Chile); Ashby, M. L. N. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Béthermin, M.; Breuck, C. de; Gullberg, B. [European Southern Observatory, Karl Schwarzschild Straße 2, D-85748 Garching (Germany); Bothwell, M. S. [Cavendish Laboratory, University of Cambridge, JJ Thompson Ave, Cambridge CB3 0HA (United Kingdom); Brandt, W. N. [Institute for Gravitation and the Cosmos, The Pennsylvania State University, University Park, PA 16802 (United States); Carlstrom, J. E. [Kavli Institute for Cosmological Physics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Chapman, S. C. [Dalhousie University, Halifax, Nova Scotia (Canada); Hezaveh, Y. [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, Stanford, CA 94305 (United States); Litke, K.; Marrone, D. P.; Spilker, J. S. [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Malkan, M. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095-1547 (United States); McDonald, M. [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, 37-582C, Cambridge, MA 02139 (United States); Murphy, E. J., E-mail: jingzhema@ufl.edu [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); and others

    2016-12-01

    We present Chandra ACIS-S and Australia Telescope Compact Array (ATCA) radio continuum observations of the strongly lensed dusty, star-forming galaxy SPT-S J034640-5204.9 (hereafter SPT0346-52) at z = 5.656. This galaxy has also been observed with ALMA, HST , Spitzer , Herschel , Atacama Pathfinder EXperiment, and the Very Large Telescope. Previous observations indicate that if the infrared (IR) emission is driven by star formation, then the inferred lensing-corrected star formation rate (SFR) (∼4500 M {sub ☉} yr{sup −1}) and SFR surface density Σ{sub SFR} (∼2000 M {sub ☉} yr{sup −1} kpc{sup −2}) are both exceptionally high. It remained unclear from the previous data, however, whether a central active galactic nucleus (AGN) contributes appreciably to the IR luminosity. The Chandra upper limit shows that SPT0346-52 is consistent with being star formation dominated in the X-ray, and any AGN contribution to the IR emission is negligible. The ATCA radio continuum upper limits are also consistent with the FIR-to-radio correlation for star-forming galaxies with no indication of an additional AGN contribution. The observed prodigious intrinsic IR luminosity of (3.6 ± 0.3) × 10{sup 13} L {sub ☉} originates almost solely from vigorous star formation activity. With an intrinsic source size of 0.61 ± 0.03 kpc, SPT0346-52 is confirmed to have one of the highest Σ{sub SFR} of any known galaxy. This high Σ{sub SFR}, which approaches the Eddington limit for a radiation pressure supported starburst, may be explained by a combination of very high star formation efficiency and gas fraction.

  19. Optical and near-infrared IFU spectroscopy of the nuclear region of the AGN-starburst galaxy NGC 7582

    Science.gov (United States)

    Ricci, T. V.; Steiner, J. E.; May, D.; Garcia-Rissmann, A.; Menezes, R. B.

    2018-02-01

    NGC 7582 is an SB(s)ab galaxy which displays evidences of simultaneous nuclear activity and star formation in its centre. Previous optical observations revealed, besides the H II regions, an ionization cone and a gas disc in its central part. Hubble Space Telescope (HST) images in both optical and infrared bands show the active galactic nuclei (AGNs) and a few compact structures that are possibly associated with young stellar clusters. In order to study in detail both the AGN and evidence for star formation, we analyse optical (Gemini Multi-Object Spectrograph) and near-infrared (Spectrograph for Integral Field Observations in the Near Infrared) archival data cubes. We detected five nebulae with strong He II λ4686 emission in the same region where an outflow is detected in the [O III] λ5007 kinematic map. We interpreted this result as clouds that are exposed to high-energy photons emerging from the AGN throughout the ionization cone. We also detected Wolf-Rayet features which are related to emission of one of the compact clusters seen in the HST image. Broad Hα and Br γ components are detected at the position of the nucleus. [Fe II] λ1.644 μm, H2λ2.122 μm and Br γ flux maps show two blobs, one north and the other south from the nucleus, that seem to be associated with five previously detected mid-infrared sources. Two of the five He II nebulae are partially ionized by photons from starbursts. However, we conclude that the main source of excitation of these blobs is the AGN jet/disc. The jet orientation indicates that the accretion disc is nearly orthogonal to the dusty torus.

  20. Social networks: Evolving graphs with memory dependent edges

    Science.gov (United States)

    Grindrod, Peter; Parsons, Mark

    2011-10-01

    The plethora of digital communication technologies, and their mass take up, has resulted in a wealth of interest in social network data collection and analysis in recent years. Within many such networks the interactions are transient: thus those networks evolve over time. In this paper we introduce a class of models for such networks using evolving graphs with memory dependent edges, which may appear and disappear according to their recent history. We consider time discrete and time continuous variants of the model. We consider the long term asymptotic behaviour as a function of parameters controlling the memory dependence. In particular we show that such networks may continue evolving forever, or else may quench and become static (containing immortal and/or extinct edges). This depends on the existence or otherwise of certain infinite products and series involving age dependent model parameters. We show how to differentiate between the alternatives based on a finite set of observations. To test these ideas we show how model parameters may be calibrated based on limited samples of time dependent data, and we apply these concepts to three real networks: summary data on mobile phone use from a developing region; online social-business network data from China; and disaggregated mobile phone communications data from a reality mining experiment in the US. In each case we show that there is evidence for memory dependent dynamics, such as that embodied within the class of models proposed here.

  1. Evolving R Coronae Borealis Stars with MESA

    Science.gov (United States)

    Clayton, Geoffrey C.; Lauer, Amber; Chatzopoulos, Emmanouil; Frank, Juhan

    2018-01-01

    R Coronae Borealis (RCB) stars form a small class of cool, carbon-rich supergiants that have almost no hydrogen. They undergo extreme, irregular declines in brightness of up to 8 magnitudes due to the formation of thick clouds of carbon dust. Two scenarios have been proposed for the origin of an RCB star: the merger of a CO/He white dwarf (WD) binary and a final helium-shell flash. We are using a combination of 3D hydrodynamics codes and the 1D MESA (Modules for Experiments in Stellar Astrophysics) stellar evolution code including nucleosynthesis to construct post-merger spherical models based on realistic merger progenitor models and on our hydrodynamical simulations, and then following the evolution into the region of the HR diagram where RCB stars are located. We are investigating nucleosynthesis in the dynamically accreting material of CO/He WD mergers which may provide a suitable environment for significant production of 18O and the very low 16O/18O values observed.Our MESA modeling consists of two steps: first mimicking the WD merger event using two different techniques, (a) by choosing a very high mass accretion rate with appropriate abundances and (b) by applying "stellar engineering" to an initial CO WD model to account for the newly merged material by applying an entropy adjusting procedure. Second, we follow the post-merger evolution using a large nuclear reaction network including the effects of convective and rotational instabilities to the mixing of material in order to match the observed RCB abundances. MESA follows the evolution of the merger product as it expands and cools to become an RCB star. We then examine the surface abundances and compare them to the observed RCB abundances. We also investigate how long fusion continues in the He shell near the core and how this processed material is mixed up to the surface of the star. We then model the later evolution of RCB stars to determine their likely lifetimes and endpoints when they have returned to

  2. Evolvability Search: Directly Selecting for Evolvability in order to Study and Produce It

    DEFF Research Database (Denmark)

    Mengistu, Henok; Lehman, Joel Anthony; Clune, Jeff

    2016-01-01

    One hallmark of natural organisms is their significant evolvability, i.e.,their increased potential for further evolution. However, reproducing such evolvability in artificial evolution remains a challenge, which both reduces the performance of evolutionary algorithms and inhibits the study...... of evolvable digital phenotypes. Although some types of selection in evolutionary computation indirectly encourage evolvability, one unexplored possibility is to directly select for evolvability. To do so, we estimate an individual's future potential for diversity by calculating the behavioral diversity of its...... immediate offspring, and select organisms with increased offspring variation. While the technique is computationally expensive, we hypothesized that direct selection would better encourage evolvability than indirect methods. Experiments in two evolutionary robotics domains confirm this hypothesis: in both...

  3. Cutting the Composite Gordian Knot: Untangling the AGN-Starburst Threads in Single Aperture Spectra

    Science.gov (United States)

    Flury, Sophia; Moran, Edward C.

    2018-01-01

    Standard emission line diagnostics are able to segregate star-forming galaxies and Seyfert nuclei, and it is often assumed that ambiguous emission-line galaxies falling between these two populations are “composite” objects exhibiting both types of photoionization. We have developed a method that predicts the most probable H II and AGN components that could plausibly explain the “composite” classed objects solely on the basis of their SDSS spectra. The majority of our analysis is driven by empirical relationships revealed by SDSS data rather than theoretical models founded in assumptions. To verify our method, we have compared the predictions of our model with publicly released IFU data from the S7 survey and find that composite objects are not in fact a simple linear combination of the two types of emission. The data reveal a key component in the mixing sequence: geometric dilution of the ionizing radiation which powers the NLR of the active nucleus. When accounting for this effect, our model is successful when applied to several composite-class galaxies. Some objects, however, appear to be at variance with the predicted results, suggesting they may not be powered by black hole accretion.

  4. Evolved atmospheric entry corridor with safety factor

    Science.gov (United States)

    Liang, Zixuan; Ren, Zhang; Li, Qingdong

    2018-02-01

    Atmospheric entry corridors are established in previous research based on the equilibrium glide condition which assumes the flight-path angle to be zero. To get a better understanding of the highly constrained entry flight, an evolved entry corridor that considers the exact flight-path angle is developed in this study. Firstly, the conventional corridor in the altitude vs. velocity plane is extended into a three-dimensional one in the space of altitude, velocity, and flight-path angle. The three-dimensional corridor is generated by a series of constraint boxes. Then, based on a simple mapping method, an evolved two-dimensional entry corridor with safety factor is obtained. The safety factor is defined to describe the flexibility of the flight-path angle for a state within the corridor. Finally, the evolved entry corridor is simulated for the Space Shuttle and the Common Aero Vehicle (CAV) to demonstrate the effectiveness of the corridor generation approach. Compared with the conventional corridor, the evolved corridor is much wider and provides additional information. Therefore, the evolved corridor would benefit more to the entry trajectory design and analysis.

  5. Emergent spacetime in stochastically evolving dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Afshordi, Niayesh [Perimeter Institute for Theoretical Physics, 31 Caroline St. N., Waterloo, ON, N2L 2Y5 (Canada); Department of Physics and Astronomy, University of Waterloo, Waterloo, ON, N2L 3G1 (Canada); HEPCOS, Department of Physics, SUNY at Buffalo, Buffalo, NY 14260-1500 (United States); Stojkovic, Dejan, E-mail: ds77@buffalo.edu [Perimeter Institute for Theoretical Physics, 31 Caroline St. N., Waterloo, ON, N2L 2Y5 (Canada); HEPCOS, Department of Physics, SUNY at Buffalo, Buffalo, NY 14260-1500 (United States)

    2014-12-12

    Changing the dimensionality of the space–time at the smallest and largest distances has manifold theoretical advantages. If the space is lower dimensional in the high energy regime, then there are no ultraviolet divergencies in field theories, it is possible to quantize gravity, and the theory of matter plus gravity is free of divergencies or renormalizable. If the space is higher dimensional at cosmological scales, then some cosmological problems (including the cosmological constant problem) can be attacked from a completely new perspective. In this paper, we construct an explicit model of “evolving dimensions” in which the dimensions open up as the temperature of the universe drops. We adopt the string theory framework in which the dimensions are fields that live on the string worldsheet, and add temperature dependent mass terms for them. At the Big Bang, all the dimensions are very heavy and are not excited. As the universe cools down, dimensions open up one by one. Thus, the dimensionality of the space we live in depends on the energy or temperature that we are probing. In particular, we provide a kinematic Brandenberger–Vafa argument for how a discrete causal set, and eventually a continuum (3+1)-dim spacetime along with Einstein gravity emerges in the Infrared from the worldsheet action. The (3+1)-dim Planck mass and the string scale become directly related, without any compactification. Amongst other predictions, we argue that LHC might be blind to new physics even if it comes at the TeV scale. In contrast, cosmic ray experiments, especially those that can register the very beginning of the shower, and collisions with high multiplicity and density of particles, might be sensitive to the dimensional cross-over.

  6. Emergent spacetime in stochastically evolving dimensions

    Science.gov (United States)

    Afshordi, Niayesh; Stojkovic, Dejan

    2014-12-01

    Changing the dimensionality of the space-time at the smallest and largest distances has manifold theoretical advantages. If the space is lower dimensional in the high energy regime, then there are no ultraviolet divergencies in field theories, it is possible to quantize gravity, and the theory of matter plus gravity is free of divergencies or renormalizable. If the space is higher dimensional at cosmological scales, then some cosmological problems (including the cosmological constant problem) can be attacked from a completely new perspective. In this paper, we construct an explicit model of ;evolving dimensions; in which the dimensions open up as the temperature of the universe drops. We adopt the string theory framework in which the dimensions are fields that live on the string worldsheet, and add temperature dependent mass terms for them. At the Big Bang, all the dimensions are very heavy and are not excited. As the universe cools down, dimensions open up one by one. Thus, the dimensionality of the space we live in depends on the energy or temperature that we are probing. In particular, we provide a kinematic Brandenberger-Vafa argument for how a discrete causal set, and eventually a continuum (3 + 1)-dim spacetime along with Einstein gravity emerges in the Infrared from the worldsheet action. The (3 + 1)-dim Planck mass and the string scale become directly related, without any compactification. Amongst other predictions, we argue that LHC might be blind to new physics even if it comes at the TeV scale. In contrast, cosmic ray experiments, especially those that can register the very beginning of the shower, and collisions with high multiplicity and density of particles, might be sensitive to the dimensional cross-over.

  7. Emergent spacetime in stochastically evolving dimensions

    Directory of Open Access Journals (Sweden)

    Niayesh Afshordi

    2014-12-01

    Full Text Available Changing the dimensionality of the space–time at the smallest and largest distances has manifold theoretical advantages. If the space is lower dimensional in the high energy regime, then there are no ultraviolet divergencies in field theories, it is possible to quantize gravity, and the theory of matter plus gravity is free of divergencies or renormalizable. If the space is higher dimensional at cosmological scales, then some cosmological problems (including the cosmological constant problem can be attacked from a completely new perspective. In this paper, we construct an explicit model of “evolving dimensions” in which the dimensions open up as the temperature of the universe drops. We adopt the string theory framework in which the dimensions are fields that live on the string worldsheet, and add temperature dependent mass terms for them. At the Big Bang, all the dimensions are very heavy and are not excited. As the universe cools down, dimensions open up one by one. Thus, the dimensionality of the space we live in depends on the energy or temperature that we are probing. In particular, we provide a kinematic Brandenberger–Vafa argument for how a discrete causal set, and eventually a continuum (3+1-dim spacetime along with Einstein gravity emerges in the Infrared from the worldsheet action. The (3+1-dim Planck mass and the string scale become directly related, without any compactification. Amongst other predictions, we argue that LHC might be blind to new physics even if it comes at the TeV scale. In contrast, cosmic ray experiments, especially those that can register the very beginning of the shower, and collisions with high multiplicity and density of particles, might be sensitive to the dimensional cross-over.

  8. Structure and kinematics of the clouds surrounding the Galactic mini-starburst W43 MM1

    Science.gov (United States)

    Jacq, T.; Braine, J.; Herpin, F.; van der Tak, F.; Wyrowski, F.

    2016-10-01

    Massive stars have a major influence on their environment, yet their formation is difficult to study as they form quickly in highly obscured regions and are rare, hence more distant than lower mass stars. Westerhout 43 (W43) is a highly luminous galactic massive star-forming region at a distance of 5.5 kpc and the MM1 part hosts a particularly massive dense core (1000 M⊙ within 0.05 pc). We present new Herschel HIFI maps of the W43 MM1 region covering the main low-energy water lines at 557, 987, and 1113 GHz; their HO counterparts; and other lines such as 13CO (10-9) and C18O (9-8), which trace warm gas. These water lines are, with the exception of line wings, observed in absorption. Herschel SPIRE and JCMT 450 μm data have been used to make a model of the continuum emission at the HIFI wavelengths. Analysis of the maps, and in particular the optical depth maps of each line and feature, shows that a velocity gradient, possibly due to rotation, is present in both the envelope (r ≳ 0.5 pc) and the protostellar core (r ≲ 0.2 pc). Velocities increase in both components from SW to NE, following the general source orientation. While the H2O lines trace essentially the cool envelope, we show that the envelope cannot account for the HO absorption, which traces motions close to the protostar. The core has rapid infall, 2.9 km s-1, as manifested by the HO absorption features which are systematically redshifted with respect to the 13CO (10-9) emission line which also traces the inner material with the same angular resolution. Some HO absorption is detected outside the central core and thus outside the regions expected (from a spherical model) to be above 100 K; we attribute this to warm gas associated with the other massive dense cores in W43 MM1. Using the maps to identify absorption from cool gas on large scales, we subtract this component to model spectra for the inner envelope. Modeling the new, presumably corrected, spectra results in a lower water abundance

  9. Establishing credibility: Evolving perceptions of the European Central Bank

    OpenAIRE

    Linda S. Goldberg; Klein, Michael W

    2005-01-01

    The credibility of a central bank’s anti-inflation stance, a key determinant of its success, may reflect institutional structure or, more dynamically, the history of policy decisions. The first years of the European Central Bank (ECB) provide a natural experiment for considering whether, and how, central bank credibility evolves. In this paper, we present a model demonstrating how the high-frequency response of asset prices to news reflects market perceptions of the anti-inflation stance of a...

  10. Interactively Evolving Compositional Sound Synthesis Networks

    DEFF Research Database (Denmark)

    Jónsson, Björn Þór; Hoover, Amy K.; Risi, Sebastian

    2015-01-01

    While the success of electronic music often relies on the uniqueness and quality of selected timbres, many musicians struggle with complicated and expensive equipment and techniques to create their desired sounds. Instead, this paper presents a technique for producing novel timbres that are evolved......, CPPNs can theoretically compute any function and can build on those present in traditional synthesizers (e.g. square, sawtooth, triangle, and sine waves functions) to produce completely novel timbres. Evolved with NeuroEvolution of Augmenting Topologies (NEAT), the aim of this paper is to explore...... the space of potential sounds that can be generated through such compositional sound synthesis networks (CSSNs). To study the effect of evolution on subjective appreciation, participants in a listener study ranked evolved timbres by personal preference, resulting in preferences skewed toward the first...

  11. Quantifying evolvability in small biological networks

    Energy Technology Data Exchange (ETDEWEB)

    Nemenman, Ilya [Los Alamos National Laboratory; Mugler, Andrew [COLUMBIA UNIV; Ziv, Etay [COLUMBIA UNIV; Wiggins, Chris H [COLUMBIA UNIV

    2008-01-01

    The authors introduce a quantitative measure of the capacity of a small biological network to evolve. The measure is applied to a stochastic description of the experimental setup of Guet et al. (Science 2002, 296, pp. 1466), treating chemical inducers as functional inputs to biochemical networks and the expression of a reporter gene as the functional output. The authors take an information-theoretic approach, allowing the system to set parameters that optimise signal processing ability, thus enumerating each network's highest-fidelity functions. All networks studied are highly evolvable by the measure, meaning that change in function has little dependence on change in parameters. Moreover, each network's functions are connected by paths in the parameter space along which information is not significantly lowered, meaning a network may continuously change its functionality without completely losing it along the way. This property further underscores the evolvability of the networks.

  12. Gravity Effects on Information Filtering and Network Evolving

    Science.gov (United States)

    Liu, Jin-Hu; Zhang, Zi-Ke; Chen, Lingjiao; Liu, Chuang; Yang, Chengcheng; Wang, Xueqi

    2014-01-01

    In this paper, based on the gravity principle of classical physics, we propose a tunable gravity-based model, which considers tag usage pattern to weigh both the mass and distance of network nodes. We then apply this model in solving the problems of information filtering and network evolving. Experimental results on two real-world data sets, Del.icio.us and MovieLens, show that it can not only enhance the algorithmic performance, but can also better characterize the properties of real networks. This work may shed some light on the in-depth understanding of the effect of gravity model. PMID:24622162

  13. Evolving Intelligent Systems Methodology and Applications

    CERN Document Server

    Angelov, Plamen; Kasabov, Nik

    2010-01-01

    From theory to techniques, the first all-in-one resource for EIS. There is a clear demand in advanced process industries, defense, and Internet and communication (VoIP) applications for intelligent yet adaptive/evolving systems. Evolving Intelligent Systems is the first self- contained volume that covers this newly established concept in its entirety, from a systematic methodology to case studies to industrial applications. Featuring chapters written by leading world experts, it addresses the progress, trends, and major achievements in this emerging research field, with a strong emphasis on th

  14. Starbursts in cooling flows: blue continua and emission-line nebulae in central cluster galaxies

    Science.gov (United States)

    Allen, S. W.

    1995-10-01

    Optical spectroscopy of X-ray-luminous clusters of galaxies detected in the ROSAT All-Sky Survey provides new evidence for ongoing star formation in the central cluster galaxies (CCGs) of clusters with cooling flows. The CCG spectra, corrected for intrinsic reddening of 0.1~10^6 O stars to be present in the most luminous systems. Large B, A and F star populations are also inferred. Photoionization models show that the observed O stars may be responsible for much of the strong, nebular line emission seen in the galaxies. This is supported by a linear correlation between the number of O stars and the Hα luminosities of the CCGs. No correlation between the emission-line luminosity and radio power is observed. The data presented here are amongst the most compelling yet for massive star formation in cooling flows and suggest that the dominant source of the spatially extended excess UV/blue continua, frequently observed in CCGs, is young stars rather than scattered non-thermal emission from hidden active nuclei.

  15. Spectroscopic Studies of Starburst Galaxies; the Dynamical Structure of Blue Compact Dwarf Galaxy Haro 6

    Directory of Open Access Journals (Sweden)

    Mun-Suk Chun

    1995-06-01

    Full Text Available We carried out photometric and spectroscopic observations of the blue compact dwarf galaxy Haro 6 in the Virgo Cluster of Galaxies. The long-slit spectroscopy was employed at three position angles, ϕ = 0°, ϕ = 30°, and ϕ = 120° CCD camera mounted on the Cassegrain Spectrograph. Based on the mean intrinsic axial ratio q0=0.3, we derived inclination i of the system as 44° our composite V-band CCD image. Careful analysis on the velocity field of the system chows an asymptotically flat rotation curve with the maximum rotational velocity V(rmax reaches about 12 km/sec. The calculation of the dynamical mass of Haro 6 with a simple mass model is briefly discussed with emphasis on the mass to luminosity ratio. From the IRAS Point Source Catalogue, we derived dust-to-gas ratio which indicates relatively low dust content, thus tempting us to conjecture the youth of the system.

  16. Preface: evolving rotifers, evolving science: Proceedings of the XIV International Rotifer Symposium

    Czech Academy of Sciences Publication Activity Database

    Devetter, Miloslav; Fontaneto, D.; Jersabek, Ch.D.; Welch, D.B.M.; May, L.; Walsh, E.J.

    2017-01-01

    Roč. 796, č. 1 (2017), s. 1-6 ISSN 0018-8158 Institutional support: RVO:60077344 Keywords : evolving rotifers * 14th International Rotifer Symposium * evolving science Subject RIV: EG - Zoology OBOR OECD: Zoology Impact factor: 2.056, year: 2016

  17. Solution-processed, undoped, deep-blue organic light-emitting diodes based on starburst oligofluorenes with a planar triphenylamine core.

    Science.gov (United States)

    Liu, Cui; Li, Yanhu; Zhang, Yingyue; Yang, Chuluo; Wu, Hongbin; Qin, Jingui; Cao, Yong

    2012-05-29

    A series of starburst oligomers (T1-T3) that contained a fully diarylmethene-bridged triphenylamine core and oligofluorene arms were designed and synthesized through Suzuki cross-coupling reactions. Their thermal, photophysical, and electrochemical properties were also investigated. These materials showed high glass transition, in the range of 123-129 °C, and good film-forming abilities. They displayed deep-blue emission both in solution and as thin films. Solution-processed devices based on these oligomers exhibited highly efficient deep-blue electroluminescence and the device performances were significantly enhanced with the extension of the oligofluorene arms. The double-layered device that contained T3 as an emitter showed a maximum current efficiency of 3.83 cd A(-1) and a maximum external quantum efficiency of 4.19% with CIE coordinates of (0.16, 0.09), which are among the highest values for undoped deep-blue OLEDs that are based on solution-processable starburst oligomers. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Thermal and Evolved-Gas Analyzer Illustration

    Science.gov (United States)

    2008-01-01

    This is a computer-aided drawing of the Thermal and Evolved-Gas Analyzer, or TEGA, on NASA's Phoenix Mars Lander. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  19. Apollo 16 Evolved Lithology Sodic Ferrogabbro

    Science.gov (United States)

    Zeigler, Ryan; Jolliff, B. L.; Korotev, R. L.

    2014-01-01

    Evolved lunar igneous lithologies, often referred to as the alkali suite, are a minor but important component of the lunar crust. These evolved samples are incompatible-element rich samples, and are, not surprisingly, most common in the Apollo sites in (or near) the incompatible-element rich region of the Moon known as the Procellarum KREEP Terrane (PKT). The most commonly occurring lithologies are granites (A12, A14, A15, A17), monzogabbro (A14, A15), alkali anorthosites (A12, A14), and KREEP basalts (A15, A17). The Feldspathic Highlands Terrane is not entirely devoid of evolved lithologies, and rare clasts of alkali gabbronorite and sodic ferrogabbro (SFG) have been identified in Apollo 16 station 11 breccias 67915 and 67016. Curiously, nearly all pristine evolved lithologies have been found as small clasts or soil particles, exceptions being KREEP basalts 15382/6 and granitic sample 12013 (which is itself a breccia). Here we reexamine the petrography and geochemistry of two SFG-like particles found in a survey of Apollo 16 2-4 mm particles from the Cayley Plains 62283,7-15 and 62243,10-3 (hereafter 7-15 and 10-3 respectively). We will compare these to previously reported SFG samples, including recent analyses on the type specimen of SFG from lunar breccia 67915.

  20. Fuzzily Connected Multimodel Systems Evolving Autonomously From Data Streams.

    Science.gov (United States)

    Angelov, P

    2011-08-01

    A general framework and a holistic concept are proposed in this paper that combine computationally light machine learning from streaming data with the online identification and adaptation of dynamic systems in regard to their structure and parameters. According to this concept, the system is assumed to be decomposable into a set of fuzzily connected simple local models. The main thrust of this paper is in the development of an original approach for the self-design, self-monitoring, self-management, and self-learning of such systems in a dynamic manner from data streams which automatically detect and react to the shift in the data distribution by evolving the system structure. Novelties of this contribution lie in the following: 1) the computationally simple approach (simpl_e_Clustering-simplified evolving Clustering) to data space partitioning by recursive evolving clustering based on the relative position of the new data sample to the mean of the overall data, 2) the learning technique for online structure evolution as a reaction to the shift in the data distribution, 3) the method for online system structure simplification based on utility and inputs/feature selection, and 4) the novel graphical illustration of the spatiotemporal evolution of the data stream. The application domain for this computationally efficient technique ranges from clustering, modeling, prognostics, classification, and time-series prediction to pattern recognition, image segmentation, vector quantization, etc., to more general problems in various application areas, e.g., intelligent sensors, mobile robotics, advanced manufacturing processes, etc.

  1. The Pyrolysis Behavior of Evolved Species from Date Palm Seeds

    Directory of Open Access Journals (Sweden)

    Babiker Mohammed Elamen

    2014-07-01

    Full Text Available The pyrolytic behavior of evolved gases from date palm seeds (DPSs were measured to gain insight into the mechanism of DPSs pyrolysis. Six different cultivars were used in this study, namely Deglet nour, Piarom, Suffry, Safawi, Mabroom and Aliya. A thermo-gravimetric analyzer (TGA and a real-time gas analyzer (GA were used to calculate the mass losses and the mole fraction of evolved gases, respectively. DPSs samples were pyrolyzed in an inert atmosphere condition using argon with a purge rate of 100 mL/minute. The samples were subjected to non-isothermal operation. An independent single model and parallel reaction model were adopted to interpret the empirical data collected from TGA and GA, respectively. The results reveled that there are three types of pyrolysis zones depending on the main constituents of every cultivars. Moreover, the potentialty of the zones in controlling the pyrolysis behavior was noticeable. The dominant hydrocarbon species in DPSs were CO and CH4 (40 to 50% higher than the rest of species. The mole fraction of CO was 2 to 4 times higher than the mole fraction of CO2. The activation energy and frequency factor of DPSs evolved species showed that Mabroom has the highest activation energy regarding H2 (63.21kJ/mol and CO (74.32 kJ/mol.

  2. Cosmic rays and the magnetic field in the nearby starburst galaxy NGC 253 III. Helical magnetic fields in the nuclear outflow

    Science.gov (United States)

    Heesen, V.; Beck, R.; Krause, M.; Dettmar, R.-J.

    2011-11-01

    Context. Magnetic fields are good tracers of gas compression by shock waves in the interstellar medium. These can be caused by the interaction of star-formation driven outflows from individual star formation sites as described in the chimney model. Integration along the line-of-sight and cosmic-ray diffusion may hamper detection of compressed magnetic fields in many cases. Aims. We study the magnetic field structure in the central part of the nuclear starburst galaxy NGC 253 with spatial resolutions between 40 and 150 pc to detect any filamentary emission associated with the nuclear outflow. As the nuclear region is much brighter than the rest of the disc we can distinguish this emission from that of the disc. Methods. We used radio polarimetric observations with the VLA. New observations at λ3 cm with 7.5 arcsec resolution were combined with archive data at λλ 20 and 6 cm. We created a map of the rotation measure distribution between λλ 6 and 3 cm and compared it with a synthetic polarization map. Results. We find filamentary radio continuum emission in a geometrical distribution, which we interpret as the boundary of the NW nuclear outflow cone seen in projection. The scaleheight of the continuum emission is 150 ± 20 pc, regardless of the observing frequency. The equipartition magnetic field strength is 46 ± 10 μG for the total field and 21 ± 5 μG for the regular field in the filaments. We find that the ordered magnetic field is aligned along the filaments, in agreement with amplification due to compression. The perpendicular diffusion coefficient across the filaments is κ⊥= 1.5-1028 cm2 s-1 E(GeV)0.5±0.7. In the SE part of the nuclear outflow cone the magnetic field is pointing away from the disc in form of a helix, with an azimuthal component increasing up to at least 1200 pc height, where it is about equal to the total component. The ordered magnetic field in the disc is anisotropic within a radius of 2.2 kpc. At larger radii, the large

  3. f(R) gravity solutions for evolving wormholes

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Subhra [Presidency University, Department of Mathematics, Kolkata (India); Chakraborty, Subenoy [Jadavpur University, Department of Mathematics, Kolkata (India)

    2017-08-15

    The scalar-tensor f(R) theory of gravity is considered in the framework of a simple inhomogeneous space-time model. In this research we use the reconstruction technique to look for possible evolving wormhole solutions within viable f(R) gravity formalism. These f(R) models are then constrained so that they are consistent with existing experimental data. Energy conditions related to the matter threading the wormhole are analyzed graphically and are in general found to obey the null energy conditions (NEC) in regions around the throat, while in the limit f(R) = R, NEC can be violated at large in regions around the throat. (orig.)

  4. Evolving wormhole geometries within nonlinear electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Arellano, Aaron V B [Facultad de Ciencias, Universidad Autonoma del Estado de Mexico, El Cerrillo, Piedras Blancas, CP 50200, Toluca (Mexico); Lobo, Francisco S N [Centro de Astronomia e Astrofisica da Universidade de Lisboa, Campo Grande, Ed C8 1749-016 Lisbon (Portugal)

    2006-10-21

    In this work, we explore the possibility of evolving (2 + 1) and (3 + 1)-dimensional wormhole spacetimes, conformally related to the respective static geometries, within the context of nonlinear electrodynamics. For (3 + 1)-dimensional spacetime, it is found that the Einstein field equation imposes a contracting wormhole solution and the obedience of the weak energy condition. Nevertheless, in the presence of an electric field, the latter presents a singularity at the throat; however, for a pure magnetic field the solution is regular. For (2 + 1)-dimensional case, it is also found that the physical fields are singular at the throat. Thus, taking into account the principle of finiteness, which states that a satisfactory theory should avoid physical quantities becoming infinite, one may rule out evolving (3 + 1)-dimensional wormhole solutions, in the presence of an electric field, and (2 + 1)-dimensional case coupled to nonlinear electrodynamics.

  5. Continual Learning through Evolvable Neural Turing Machines

    DEFF Research Database (Denmark)

    Lüders, Benno; Schläger, Mikkel; Risi, Sebastian

    2016-01-01

    Continual learning, i.e. the ability to sequentially learn tasks without catastrophic forgetting of previously learned ones, is an important open challenge in machine learning. In this paper we take a step in this direction by showing that the recently proposed Evolving Neural Turing Machine (ENT......) approach is able to perform one-shot learning in a reinforcement learning task without catastrophic forgetting of previously stored associations.......Continual learning, i.e. the ability to sequentially learn tasks without catastrophic forgetting of previously learned ones, is an important open challenge in machine learning. In this paper we take a step in this direction by showing that the recently proposed Evolving Neural Turing Machine (ENTM...

  6. Designing Garments to Evolve Over Time

    DEFF Research Database (Denmark)

    Riisberg, Vibeke; Grose, Lynda

    2017-01-01

    This paper proposes a REDO of the current fashion paradigm by investigating how garments might be designed to evolve over time. The purpose is to discuss ways of expanding the traditional role of the designer to include temporal dimensions of creating, producing and using clothes and to suggest a...... to a REDO of design education, to further research and the future fashion and textile industry.......This paper proposes a REDO of the current fashion paradigm by investigating how garments might be designed to evolve over time. The purpose is to discuss ways of expanding the traditional role of the designer to include temporal dimensions of creating, producing and using clothes and to suggest...... a range of potential fashion futures that decouple from declining resources. In the first part literature on 'Past and Present' historical and current aspects of sustainability in fashion and textiles are presented. In the second part, three exploratory case studies are described: Two projects by students...

  7. Antibody therapeutics - the evolving patent landscape.

    Science.gov (United States)

    Petering, Jenny; McManamny, Patrick; Honeyman, Jane

    2011-09-01

    The antibody patent landscape has evolved dramatically over the past 30 years, particularly in areas of technology relating to antibody modification to reduce immunogenicity in humans or improve antibody function. In some cases antibody techniques that were developed in the 1980s are still the subject of patent protection in the United States or Canada. Copyright © 2011 Elsevier B.V. All rights reserved.

  8. The evolving epidemiology of inflammatory bowel disease.

    LENUS (Irish Health Repository)

    Shanahan, Fergus

    2009-07-01

    Epidemiologic studies in inflammatory bowel disease (IBD) include assessments of disease burden and evolving patterns of disease presentation. Although it is hoped that sound epidemiologic studies provide aetiological clues, traditional risk factor-based epidemiology has provided limited insights into either Crohn\\'s disease or ulcerative colitis etiopathogenesis. In this update, we will summarize how the changing epidemiology of IBD associated with modernization can be reconciled with current concepts of disease mechanisms and will discuss studies of clinically significant comorbidity in IBD.

  9. Directional Communication in Evolved Multiagent Teams

    Science.gov (United States)

    2013-06-10

    networks. Artificial Life, 15(2):185– 212, 2009. [23] K. O. Stanley and R. Miikkulainen. Evolving neural networks through augmenting topologies ...paper. 2.2 Neuroevolution of Augmenting Topologies The HyperNEAT approach is itself an extension of the original NEAT (Neu- roevolution of Augmenting ...Gauci and K. O. Stanley. Autonomous evolution of topographic regu- larities in artificial neural networks. Neural Computation, 22(7):1860–1898, 2010

  10. The Evolving Leadership Path of Visual Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Kluse, Michael; Peurrung, Anthony J.; Gracio, Deborah K.

    2012-01-02

    This is a requested book chapter for an internationally authored book on visual analytics and related fields, coordianted by a UK university and to be published by Springer in 2012. This chapter is an overview of the leadship strategies that PNNL's Jim Thomas and other stakeholders used to establish visual analytics as a field, and how those strategies may evolve in the future.

  11. Raeder paratrigeminal neuralgia evolving to hemicrania continua.

    Science.gov (United States)

    Porzukowiak, Tina Renae

    2015-04-01

    Raeder paratrigeminal neuralgia is most commonly characterized as deep, boring, nonpulsatile, severe, unilateral facial and head pain in the distribution of the V1 area combined with ipsilateral oculosympathetic palsy and autonomic symptoms. Raeder paratrigeminal neuralgia evolving into hemicrania continua, a rare primary, chronic headache syndrome characterized by unilateral pain and response to indomethacin, has rarely been documented. The purpose of this case report is to contribute to the medical literature a single case of Raeder paratrigeminal neuralgia presenting as multiple cranial nerve palsies that evolved into hemicrania continua that was successfully treated with onabotulinumtoxinA. A 52-year-old white woman presented to the emergency department with the complaint of severe, aching, constant eye pain radiating to the V1 area for 1 week with associated ptosis and photophobia of the left eye. Ocular examination revealed involvement of cranial nerves II, III, V, and VI. Additional symptoms included ipsilateral lacrimation, eyelid edema, and rhinorrhea. Extensive medical work-up showed normal results. Raeder paratrigeminal neuralgia was diagnosed with multiple cranial nerve involvement; the headache component became chronic with periodic exacerbations of autonomic symptoms evolving to a diagnosis of hemicrania continua. The patient was intolerant to traditional indomethacin treatment, and the headache was successfully treated with onabotulinumtoxinA injections. Recognition of ipsilateral signs such as miosis, ptosis, hydrosis, eyelid edema, hyperemia, rhinorrhea, or nasal congestion is useful in the differential diagnosis of painful ophthalmoplegia, particularly in the diagnosis of Raeder paratrigeminal neuralgia and hemicrania continua. This case study illustrates a rare presentation of Raeder paratrigeminal neuralgia evolving into hemicrania continua presenting as a painful ophthalmoplegia with multiple cranial nerve involvement. The example supports the

  12. Evolvability of Amyloidogenic Proteins in Human Brain

    Science.gov (United States)

    Hashimoto, Makoto; Ho, Gilbert; Sugama, Shuei; Takamatsu, Yoshiki; Shimizu, Yuka; Takenouchi, Takato; Waragai, Masaaki; Masliah, Eliezer

    2018-01-01

     Currently, the physiological roles of amyloidogenic proteins (APs) in human brain, such as amyloid-β and α-synuclein, are elusive. Given that many APs arose by gene duplication and have been resistant against the pressures of natural selection, APs may be associated with some functions that are advantageous for survival of offspring. Nonetheless, evolvability is the sole physiological quality of APs that has been characterized in microorganisms such as yeast. Since yeast and human brain may share similar strategies in coping with diverse range of critical environmental stresses, the objective of this paper was to discuss the potential role of evolvability of APs in aging-associated neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. Given the heterogeneity of APs in terms of structure and cytotoxicity, it is argued that APs might be involved in preconditioning against diverse stresses in human brain. It is further speculated that these stress-related APs, most likely protofibrillar forms, might be transmitted to offspring via the germline, conferring preconditioning against forthcoming stresses. Thus, APs might represent a vehicle for the inheritance of the acquired characteristics against environmental stresses. Curiously, such a characteristic of APs is reminiscent of Charles Darwin’s ‘gemmules’, imagined molecules of heritability described in his pangenesis theory. We propose that evolvability might be a physiological function of APs during the reproductive stage and neurodegenerative diseases could be a by-product effect manifested later in aging. Collectively, our evolvability hypothesis may play a complementary role in the pathophysiology of APs with the conventional amyloid cascade hypothesis. PMID:29439348

  13. EVOLVE : a Bridge between Probability, Set Oriented Numerics, and Evolutionary Computation II

    CERN Document Server

    Coello, Carlos; Tantar, Alexandru-Adrian; Tantar, Emilia; Bouvry, Pascal; Moral, Pierre; Legrand, Pierrick; EVOLVE 2012

    2013-01-01

    This book comprises a selection of papers from the EVOLVE 2012 held in Mexico City, Mexico. The aim of the EVOLVE is to build a bridge between probability, set oriented numerics and evolutionary computing, as to identify new common and challenging research aspects. The conference is also intended to foster a growing interest for robust and efficient methods with a sound theoretical background. EVOLVE is intended to unify theory-inspired methods and cutting-edge techniques ensuring performance guarantee factors. By gathering researchers with different backgrounds, a unified view and vocabulary can emerge where the theoretical advancements may echo in different domains. Summarizing, the EVOLVE focuses on challenging aspects arising at the passage from theory to new paradigms and aims to provide a unified view while raising questions related to reliability,  performance guarantees and modeling. The papers of the EVOLVE 2012 make a contribution to this goal. 

  14. Hubble space telescope grism spectroscopy of extreme starbursts across cosmic time: The role of dwarf galaxies in the star formation history of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Atek, Hakim; Kneib, Jean-Paul [Laboratoire d' Astrophysique, EPFL, CH-1290 Sauverny (Switzerland); Pacifici, Camilla [Yonsei University Observatory, Yonsei University, Seoul 120-749 (Korea, Republic of); Malkan, Matthew; Ross, Nathaniel [Department of Physics and Astronomy, University of California, Los Angeles, CA (United States); Charlot, Stephane; Lehnert, Matthew [UPMC-CNRS, UMR7095, Institut d' Astrophysique de Paris, F-75014 Paris (France); Lee, Janice [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Bedregal, Alejandro [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Bunker, Andrew J. [Department of Physics, University of Oxford, Denys Wilkinson Building, Keble Road, OX13RH (United Kingdom); Colbert, James W.; Rafelski, Marc [Spitzer Science Center, California Institute of Technology, Pasadena, CA 91125 (United States); Dressler, Alan; McCarthy, Patrick [Observatories of the Carnegie Institution for Science, Pasadena, CA 91101 (United States); Hathi, Nimish [Aix Marseille Université, CNRS, LAM (Laboratoire d' Astrophysique de Marseille) UMR 7326, F-13388 Marseille (France); Martin, Crystal L. [Department of Physics, University of California, Santa Barbara, CA 93106 (United States); Siana, Brian [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Teplitz, Harry I. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States)

    2014-07-10

    Near infrared slitless spectroscopy with the Wide Field Camera 3, on board the Hubble Space Telescope, offers a unique opportunity to study low-mass galaxy populations at high redshift (z ∼ 1-2). While most high-z surveys are biased toward massive galaxies, we are able to select sources via their emission lines that have very faint continua. We investigate the star formation rate (SFR)-stellar mass (M{sub *}) relation for about 1000 emission line galaxies identified over a wide redshift range of 0.3 ≲ z ≲ 2.3. We use the Hα emission as an accurate SFR indicator and correct the broadband photometry for the strong nebular contribution to derive accurate stellar masses down to M{sub *} ∼10{sup 7} M{sub ☉}. We focus here on a subsample of galaxies that show extremely strong emission lines (EELGs) with rest-frame equivalent widths ranging from 200 to 1500 Å. This population consists of outliers to the normal SFR-M{sub *} sequence with much higher specific SFRs (>10 Gyr{sup –1}). While on-sequence galaxies follow continuous star formation processes, EELGs are thought to be caught during an extreme burst of star formation that can double their stellar mass in a period of less than 100 Myr. The contribution of the starburst population to the total star formation density appears to be larger than what has been reported for more massive galaxies in previous studies. In the complete mass range 8.2 < log(M{sub *}/M{sub ☉}) <10 and a SFR lower completeness limit of about 2 M{sub ☉} yr{sup –1} (10 M{sub ☉} yr{sup –1}) at z ∼ 1 (z ∼ 2), we find that starbursts having EW{sub rest}(Hα) > 300, 200, and 100 Å contribute up to ∼13%, 18%, and 34%, respectively, to the total SFR of emission-line-selected sample at z ∼ 1-2. The comparison with samples of massive galaxies shows an increase in the contribution of starbursts toward lower masses.

  15. High-order evolving surface finite element method for parabolic problems on evolving surfaces

    OpenAIRE

    Kovács, Balázs

    2016-01-01

    High-order spatial discretisations and full discretisations of parabolic partial differential equations on evolving surfaces are studied. We prove convergence of the high-order evolving surface finite element method, by showing high-order versions of geometric approximation errors and perturbation error estimates and by the careful error analysis of a modified Ritz map. Furthermore, convergence of full discretisations using backward difference formulae and implicit Runge-Kutta methods are als...

  16. Evolving RBF neural networks for adaptive soft-sensor design.

    Science.gov (United States)

    Alexandridis, Alex

    2013-12-01

    This work presents an adaptive framework for building soft-sensors based on radial basis function (RBF) neural network models. The adaptive fuzzy means algorithm is utilized in order to evolve an RBF network, which approximates the unknown system based on input-output data from it. The methodology gradually builds the RBF network model, based on two separate levels of adaptation: On the first level, the structure of the hidden layer is modified by adding or deleting RBF centers, while on the second level, the synaptic weights are adjusted with the recursive least squares with exponential forgetting algorithm. The proposed approach is tested on two different systems, namely a simulated nonlinear DC Motor and a real industrial reactor. The results show that the produced soft-sensors can be successfully applied to model the two nonlinear systems. A comparison with two different adaptive modeling techniques, namely a dynamic evolving neural-fuzzy inference system (DENFIS) and neural networks trained with online backpropagation, highlights the advantages of the proposed methodology.

  17. Extreme CO Isotopic Abundances in the ULIRG IRAS 13120-5453: An Extremely Young Starburst or Top-heavy Initial Mass Function

    Energy Technology Data Exchange (ETDEWEB)

    Sliwa, Kazimierz [MPI for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Wilson, Christine D. [Department of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4M1 (Canada); Aalto, Susanne [Department of Earth and Space Sciences, Chalmers University of Technology, Onsala Space Observatory, SE-439 94 Onsala (Sweden); Privon, George C., E-mail: sliwa@mpia-hd.mpg.de [Instituto de Astrofśica, Facultad de Física, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 22 (Chile)

    2017-05-10

    We present ALMA {sup 12}CO (J = 1-0, 3-2 and 6-5), {sup 13}CO (J = 1-0), and C{sup 18}O (J = 1-0) observations of the local ultraluminous infrared galaxy (ULIRG) IRAS 13120-5453. The morphologies of the three isotopic species differ, as {sup 13}CO shows a hole in emission toward the center. We measure integrated brightness temperature line ratios of {sup 12}CO/{sup 13}CO ≥ 60 (exceeding 200) and {sup 13}CO/C{sup 18}O ≤ 1 in the central region. Assuming optical thin emission, C{sup 18}O is more abundant than {sup 13}CO in several regions. The abundances within the central 500 pc are consistent with the enrichment of the interstellar medium via a young starburst (<7 Myr), a top-heavy initial mass function, or a combination of both.

  18. Evolvability Is an Evolved Ability: The Coding Concept as the Arch-Unit of Natural Selection.

    Science.gov (United States)

    Janković, Srdja; Ćirković, Milan M

    2016-03-01

    Physical processes that characterize living matter are qualitatively distinct in that they involve encoding and transfer of specific types of information. Such information plays an active part in the control of events that are ultimately linked to the capacity of the system to persist and multiply. This algorithmicity of life is a key prerequisite for its Darwinian evolution, driven by natural selection acting upon stochastically arising variations of the encoded information. The concept of evolvability attempts to define the total capacity of a system to evolve new encoded traits under appropriate conditions, i.e., the accessible section of total morphological space. Since this is dependent on previously evolved regulatory networks that govern information flow in the system, evolvability itself may be regarded as an evolved ability. The way information is physically written, read and modified in living cells (the "coding concept") has not changed substantially during the whole history of the Earth's biosphere. This biosphere, be it alone or one of many, is, accordingly, itself a product of natural selection, since the overall evolvability conferred by its coding concept (nucleic acids as information carriers with the "rulebook of meanings" provided by codons, as well as all the subsystems that regulate various conditional information-reading modes) certainly played a key role in enabling this biosphere to survive up to the present, through alterations of planetary conditions, including at least five catastrophic events linked to major mass extinctions. We submit that, whatever the actual prebiotic physical and chemical processes may have been on our home planet, or may, in principle, occur at some time and place in the Universe, a particular coding concept, with its respective potential to give rise to a biosphere, or class of biospheres, of a certain evolvability, may itself be regarded as a unit (indeed the arch-unit) of natural selection.

  19. Modes of competition and the fitness of evolved populations.

    Science.gov (United States)

    Rogers, Tim; McKane, Alan J

    2015-09-01

    Competition between individuals drives the evolution of whole species. Although the fittest individuals survive the longest and produce the most offspring, in some circumstances the resulting species may not be optimally fit. Here, using theoretical analysis and stochastic simulations of a simple model ecology, we show how the mode of competition can profoundly affect the fitness of evolved species. When individuals compete directly with one another, the adaptive dynamics framework provides accurate predictions for the number and distribution of species, which occupy positions of maximal fitness. By contrast, if competition is mediated by the consumption of a common resource, then demographic noise leads to the stabilization of species with near minimal fitness.

  20. Evolved Control of Natural Plants: Crossing the Reality Gap for User-Defined Steering of Growth and Motion

    DEFF Research Database (Denmark)

    Hofstadler, Daniel Nicolas; Wahby, Mostafa; Heinrich, Mary Katherine

    2017-01-01

    in response to the simple controller is captured by image processing, and a model of the plant tip dynamics is developed. The model is used in simulation to evolve a robot controller that steers the plant tip such that it follows a number of randomly generated target points. Finally, we test the simulation-evolved...

  1. Present weather and climate: evolving conditions

    Science.gov (United States)

    Hoerling, Martin P; Dettinger, Michael; Wolter, Klaus; Lukas, Jeff; Eischeid, Jon K.; Nemani, Rama; Liebmann, Brant; Kunkel, Kenneth E.

    2013-01-01

    This chapter assesses weather and climate variability and trends in the Southwest, using observed climate and paleoclimate records. It analyzes the last 100 years of climate variability in comparison to the last 1,000 years, and links the important features of evolving climate conditions to river flow variability in four of the region’s major drainage basins. The chapter closes with an assessment of the monitoring and scientific research needed to increase confidence in understanding when climate episodes, events, and phenomena are attributable to human-caused climate change.

  2. Information theory, evolutionary innovations and evolvability.

    Science.gov (United States)

    Wagner, Andreas

    2017-12-05

    How difficult is it to 'discover' an evolutionary adaptation or innovation? I here suggest that information theory, in combination with high-throughput DNA sequencing, can help answer this question by quantifying a new phenotype's information content. I apply this framework to compute the phenotypic information associated with novel gene regulation and with the ability to use novel carbon sources. The framework can also help quantify how DNA duplications affect evolvability, estimate the complexity of phenotypes and clarify the meaning of 'progress' in Darwinian evolution.This article is part of the themed issue 'Process and pattern in innovations from cells to societies'. © 2017 The Author(s).

  3. Evolving Random Forest for Preference Learning

    DEFF Research Database (Denmark)

    Abou-Zleikha, Mohamed; Shaker, Noor

    2015-01-01

    This paper introduces a novel approach for pairwise preference learning through a combination of an evolutionary method and random forest. Grammatical evolution is used to describe the structure of the trees in the Random Forest (RF) and to handle the process of evolution. Evolved random forests ...... obtained for predicting pairwise self-reports of users for the three emotional states engagement, frustration and challenge show very promising results that are comparable and in some cases superior to those obtained from state-of-the-art methods....

  4. Netgram: Visualizing Communities in Evolving Networks.

    Directory of Open Access Journals (Sweden)

    Raghvendra Mall

    Full Text Available Real-world complex networks are dynamic in nature and change over time. The change is usually observed in the interactions within the network over time. Complex networks exhibit community like structures. A key feature of the dynamics of complex networks is the evolution of communities over time. Several methods have been proposed to detect and track the evolution of these groups over time. However, there is no generic tool which visualizes all the aspects of group evolution in dynamic networks including birth, death, splitting, merging, expansion, shrinkage and continuation of groups. In this paper, we propose Netgram: a tool for visualizing evolution of communities in time-evolving graphs. Netgram maintains evolution of communities over 2 consecutive time-stamps in tables which are used to create a query database using the sql outer-join operation. It uses a line-based visualization technique which adheres to certain design principles and aesthetic guidelines. Netgram uses a greedy solution to order the initial community information provided by the evolutionary clustering technique such that we have fewer line cross-overs in the visualization. This makes it easier to track the progress of individual communities in time evolving graphs. Netgram is a generic toolkit which can be used with any evolutionary community detection algorithm as illustrated in our experiments. We use Netgram for visualization of topic evolution in the NIPS conference over a period of 11 years and observe the emergence and merging of several disciplines in the field of information processing systems.

  5. Netgram: Visualizing Communities in Evolving Networks

    Science.gov (United States)

    Mall, Raghvendra; Langone, Rocco; Suykens, Johan A. K.

    2015-01-01

    Real-world complex networks are dynamic in nature and change over time. The change is usually observed in the interactions within the network over time. Complex networks exhibit community like structures. A key feature of the dynamics of complex networks is the evolution of communities over time. Several methods have been proposed to detect and track the evolution of these groups over time. However, there is no generic tool which visualizes all the aspects of group evolution in dynamic networks including birth, death, splitting, merging, expansion, shrinkage and continuation of groups. In this paper, we propose Netgram: a tool for visualizing evolution of communities in time-evolving graphs. Netgram maintains evolution of communities over 2 consecutive time-stamps in tables which are used to create a query database using the sql outer-join operation. It uses a line-based visualization technique which adheres to certain design principles and aesthetic guidelines. Netgram uses a greedy solution to order the initial community information provided by the evolutionary clustering technique such that we have fewer line cross-overs in the visualization. This makes it easier to track the progress of individual communities in time evolving graphs. Netgram is a generic toolkit which can be used with any evolutionary community detection algorithm as illustrated in our experiments. We use Netgram for visualization of topic evolution in the NIPS conference over a period of 11 years and observe the emergence and merging of several disciplines in the field of information processing systems. PMID:26356538

  6. BOOK REVIEW: OPENING SCIENCE, THE EVOLVING GUIDE ...

    Science.gov (United States)

    The way we get our funding, collaborate, do our research, and get the word out has evolved over hundreds of years but we can imagine a more open science world, largely facilitated by the internet. The movement towards this more open way of doing and presenting science is coming, and it is not taking hundreds of years. If you are interested in these trends, and would like to find out more about where this is all headed and what it means to you, consider downloding Opening Science, edited by Sönke Bartling and Sascha Friesike, subtitled The Evolving Guide on How the Internet is Changing Research, Collaboration, and Scholarly Publishing. In 26 chapters by various authors from a range of disciplines the book explores the developing world of open science, starting from the first scientific revolution and bringing us to the next scientific revolution, sometimes referred to as “Science 2.0”. Some of the articles deal with the impact of the changing landscape of how science is done, looking at the impact of open science on Academia, or journal publishing, or medical research. Many of the articles look at the uses, pitfalls, and impact of specific tools, like microblogging (think Twitter), social networking, and reference management. There is lots of discussion and definition of terms you might use or misuse like “altmetrics” and “impact factor”. Science will probably never be completely open, and Twitter will probably never replace the journal article,

  7. Alcohol use and policy formation: an evolving social problem.

    Science.gov (United States)

    Levine, Amir

    2012-01-01

    This article explores the evolutionary course that the social problem of alcohol use has taken in the United States since the Colonial Era. This article utilizes a range of theoretical models to analyze the evolving nature of alcohol use from an unrecognized to a perceived social problem. The models used include critical constructionism (Heiner, 2002), top-down policy model (Dye, 2001) and Mauss'(1975) understanding of social problems and movements. These theoretical constructs exhibit the relative nature of alcohol use as a social problem in regards to a specific time, place, and social context as well as the powerful and influential role that social elites have in defining alcohol asa social problem. Studies regarding the development of alcohol policy formation are discussed to illuminate the different powers, constituents, and factors that play a role in alcohol policy formation.Finally, implications for future study are discussed [corrected].

  8. Integrating the Human Sciences to Evolve Effective Policies.

    Science.gov (United States)

    Biglan, Anthony; Cody, Christine

    2013-06-01

    This paper describes an evolutionary perspective on human development and wellbeing and contrasts it with the model of self-interest that is prominent in economics. The two approaches have considerably different implications for how human wellbeing might be improved. Research in psychology, prevention science, and neuroscience is converging on an evolutionary account of the importance of two contrasting suites of social behavior-prosociality vs. antisocial behaviors (crime, drug abuse, risky sexual behavior) and related problems such as depression. Prosociality of individuals and groups evolves in environments that minimize toxic biological and social conditions, promote and richly reinforce prosocial behavior and attitudes, limit opportunities for antisocial behavior, and nurture the pursuit of prosocial values. Conversely, antisocial behavior and related problems emerge in environments that are high in threat and conflict. Over the past 30 years, randomized trials have shown numerous family, school, and community interventions to prevent most problem behaviors and promote prosociality. Research has also shown that poverty and economic inequality are major risk factors for the development of problem behaviors. The paper describes policies that can reduce poverty and benefit youth development. Although it is clear that the canonical economic model of rational self-interest has made a significant contribution to the science of economics, the evidence reviewed here shows that it must be reconciled with an evolutionary perspective on human development and wellbeing if society is going to evolve public policies that advance the health and wellbeing of the entire population.

  9. Evolvability as a Quality Attribute of Software Architectures

    NARCIS (Netherlands)

    Ciraci, S.; van den Broek, P.M.; Duchien, Laurence; D'Hondt, Maja; Mens, Tom

    We review the definition of evolvability as it appears on the literature. In particular, the concept of software evolvability is compared with other system quality attributes, such as adaptability, maintainability and modifiability.

  10. Resiliently evolving supply-demand networks.

    Science.gov (United States)

    Rubido, Nicolás; Grebogi, Celso; Baptista, Murilo S

    2014-01-01

    The ability to design a transport network such that commodities are brought from suppliers to consumers in a steady, optimal, and stable way is of great importance for distribution systems nowadays. In this work, by using the circuit laws of Kirchhoff and Ohm, we provide the exact capacities of the edges that an optimal supply-demand network should have to operate stably under perturbations, i.e., without overloading. The perturbations we consider are the evolution of the connecting topology, the decentralization of hub sources or sinks, and the intermittence of supplier and consumer characteristics. We analyze these conditions and the impact of our results, both on the current United Kingdom power-grid structure and on numerically generated evolving archetypal network topologies.

  11. The Evolving Theory of Evolutionary Radiations.

    Science.gov (United States)

    Simões, M; Breitkreuz, L; Alvarado, M; Baca, S; Cooper, J C; Heins, L; Herzog, K; Lieberman, B S

    2016-01-01

    Evolutionary radiations have intrigued biologists for more than 100 years, and our understanding of the patterns and processes associated with these radiations continues to grow and evolve. Recently it has been recognized that there are many different types of evolutionary radiation beyond the well-studied adaptive radiations. We focus here on multifarious types of evolutionary radiations, paying special attention to the abiotic factors that might trigger diversification in clades. We integrate concepts such as exaptation, species selection, coevolution, and the turnover-pulse hypothesis (TPH) into the theoretical framework of evolutionary radiations. We also discuss other phenomena that are related to, but distinct from, evolutionary radiations that have relevance for evolutionary biology. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Finch: A System for Evolving Java (Bytecode)

    Science.gov (United States)

    Orlov, Michael; Sipper, Moshe

    The established approach in genetic programming (GP) involves the definition of functions and terminals appropriate to the problem at hand, after which evolution of expressions using these definitions takes place. We have recently developed a system, dubbed FINCH (Fertile Darwinian Bytecode Harvester), to evolutionarily improve actual, extant software, which was not intentionally written for the purpose of serving as a GP representation in particular, nor for evolution in general. This is in contrast to existing work that uses restricted subsets of the Java bytecode instruction set as a representation language for individuals in genetic programming. The ability to evolve Java programs will hopefully lead to a valuable new tool in the software engineer's toolkit.

  13. Excess mutual catalysis is required for effective evolvability.

    Science.gov (United States)

    Markovitch, Omer; Lancet, Doron

    2012-01-01

    It is widely accepted that autocatalysis constitutes a crucial facet of effective replication and evolution (e.g., in Eigen's hypercycle model). Other models for early evolution (e.g., by Dyson, Gánti, Varela, and Kauffman) invoke catalytic networks, where cross-catalysis is more apparent. A key question is how the balance between auto- (self-) and cross- (mutual) catalysis shapes the behavior of model evolving systems. This is investigated using the graded autocatalysis replication domain (GARD) model, previously shown to capture essential features of reproduction, mutation, and evolution in compositional molecular assemblies. We have performed numerical simulations of an ensemble of GARD networks, each with a different set of lognormally distributed catalytic values. We asked what is the influence of the catalytic content of such networks on beneficial evolution. Importantly, a clear trend was observed, wherein only networks with high mutual catalysis propensity (p(mc)) allowed for an augmented diversity of composomes, quasi-stationary compositions that exhibit high replication fidelity. We have reexamined a recent analysis that showed meager selection in a single GARD instance and for a few nonstationary target compositions. In contrast, when we focused here on compotypes (clusters of composomes) as targets for selection in populations of compositional assemblies, appreciable selection response was observed for a large portion of the networks simulated. Further, stronger selection response was seen for high p(mc) values. Our simulations thus demonstrate that GARD can help analyze important facets of evolving systems, and indicate that excess mutual catalysis over self-catalysis is likely to be important for the emergence of molecular systems capable of evolutionlike behavior.

  14. Vibrationally excited water emission at 658 GHz from evolved stars

    Science.gov (United States)

    Baudry, A.; Humphreys, E. M. L.; Herpin, F.; Torstensson, K.; Vlemmings, W. H. T.; Richards, A. M. S.; Gray, M. D.; De Breuck, C.; Olberg, M.

    2018-01-01

    Context. Several rotational transitions of ortho- and para-water have been identified toward evolved stars in the ground vibrational state as well as in the first excited state of the bending mode (v2 = 1 in (0, 1, 0) state). In the latter vibrational state of water, the 658 GHz J = 11,0-10,1 rotational transition is often strong and seems to be widespread in late-type stars. Aims: Our main goals are to better characterize the nature of the 658 GHz emission, compare the velocity extent of the 658 GHz emission with SiO maser emission to help locate the water layers and, more generally, investigate the physical conditions prevailing in the excited water layers of evolved stars. Another goal is to identify new 658 GHz emission sources and contribute in showing that this emission is widespread in evolved stars. Methods: We have used the J = 11,0-10,1 rotational transition of water in the (0, 1, 0) vibrational state nearly 2400 K above the ground-state to trace some of the physical conditions of evolved stars. Eleven evolved stars were extracted from our mini-catalog of existing and potential 658 GHz sources for observations with the Atacama Pathfinder EXperiment (APEX) telescope equipped with the SEPIA Band 9 receiver. The 13CO J = 6-5 line at 661 GHz was placed in the same receiver sideband for simultaneous observation with the 658 GHz line of water. We have compared the ratio of these two lines to the same ratio derived from HIFI earlier observations to check for potential time variability in the 658 GHz line. We have compared the 658 GHz line properties with our H2O radiative transfer models in stars and we have compared the velocity ranges of the 658 GHz and SiO J = 2-1, v = 1 maser lines. Results: Eleven stars have been extracted from our catalog of known or potential 658 GHz evolved stars. All of them show 658 GHz emission with a peak flux density in the range ≈50-70 Jy (RU Hya and RT Eri) to ≈2000-3000 Jy (VY CMa and W Hya). Five Asymptotic Giant Branch (AGB

  15. How People Interact in Evolving Online Affiliation Networks

    Science.gov (United States)

    Gallos, Lazaros K.; Rybski, Diego; Liljeros, Fredrik; Havlin, Shlomo; Makse, Hernán A.

    2012-07-01

    The study of human interactions is of central importance for understanding the behavior of individuals, groups, and societies. Here, we observe the formation and evolution of networks by monitoring the addition of all new links, and we analyze quantitatively the tendencies used to create ties in these evolving online affiliation networks. We show that an accurate estimation of these probabilistic tendencies can be achieved only by following the time evolution of the network. Inferences about the reason for the existence of links using statistical analysis of network snapshots must therefore be made with great caution. Here, we start by characterizing every single link when the tie was established in the network. This information allows us to describe the probabilistic tendencies of tie formation and extract meaningful sociological conclusions. We also find significant differences in behavioral traits in the social tendencies among individuals according to their degree of activity, gender, age, popularity, and other attributes. For instance, in the particular data sets analyzed here, we find that women reciprocate connections 3 times as much as men and that this difference increases with age. Men tend to connect with the most popular people more often than women do, across all ages. On the other hand, triangular tie tendencies are similar, independent of gender, and show an increase with age. These results require further validation in other social settings. Our findings can be useful to build models of realistic social network structures and to discover the underlying laws that govern establishment of ties in evolving social networks.

  16. The evolving Planck mass in classically scale-invariant theories

    Science.gov (United States)

    Kannike, K.; Raidal, M.; Spethmann, C.; Veermäe, H.

    2017-04-01

    We consider classically scale-invariant theories with non-minimally coupled scalar fields, where the Planck mass and the hierarchy of physical scales are dynamically generated. The classical theories possess a fixed point, where scale invariance is spontaneously broken. In these theories, however, the Planck mass becomes unstable in the presence of explicit sources of scale invariance breaking, such as non-relativistic matter and cosmological constant terms. We quantify the constraints on such classical models from Big Bang Nucleosynthesis that lead to an upper bound on the non-minimal coupling and require trans-Planckian field values. We show that quantum corrections to the scalar potential can stabilise the fixed point close to the minimum of the Coleman-Weinberg potential. The time-averaged motion of the evolving fixed point is strongly suppressed, thus the limits on the evolving gravitational constant from Big Bang Nucleosynthesis and other measurements do not presently constrain this class of theories. Field oscillations around the fixed point, if not damped, contribute to the dark matter density of the Universe.

  17. The evolving Planck mass in classically scale-invariant theories

    Energy Technology Data Exchange (ETDEWEB)

    Kannike, K.; Raidal, M.; Spethmann, C.; Veermäe, H. [National Institute of Chemical Physics and Biophysics,Rävala 10, 10143 Tallinn (Estonia)

    2017-04-05

    We consider classically scale-invariant theories with non-minimally coupled scalar fields, where the Planck mass and the hierarchy of physical scales are dynamically generated. The classical theories possess a fixed point, where scale invariance is spontaneously broken. In these theories, however, the Planck mass becomes unstable in the presence of explicit sources of scale invariance breaking, such as non-relativistic matter and cosmological constant terms. We quantify the constraints on such classical models from Big Bang Nucleosynthesis that lead to an upper bound on the non-minimal coupling and require trans-Planckian field values. We show that quantum corrections to the scalar potential can stabilise the fixed point close to the minimum of the Coleman-Weinberg potential. The time-averaged motion of the evolving fixed point is strongly suppressed, thus the limits on the evolving gravitational constant from Big Bang Nucleosynthesis and other measurements do not presently constrain this class of theories. Field oscillations around the fixed point, if not damped, contribute to the dark matter density of the Universe.

  18. The evolving energy budget of accretionary wedges

    Science.gov (United States)

    McBeck, Jessica; Cooke, Michele; Maillot, Bertrand; Souloumiac, Pauline

    2017-04-01

    The energy budget of evolving accretionary systems reveals how deformational processes partition energy as faults slip, topography uplifts, and layer-parallel shortening produces distributed off-fault deformation. The energy budget provides a quantitative framework for evaluating the energetic contribution or consumption of diverse deformation mechanisms. We investigate energy partitioning in evolving accretionary prisms by synthesizing data from physical sand accretion experiments and numerical accretion simulations. We incorporate incremental strain fields and cumulative force measurements from two suites of experiments to design numerical simulations that represent accretionary wedges with stronger and weaker detachment faults. One suite of the physical experiments includes a basal glass bead layer and the other does not. Two physical experiments within each suite implement different boundary conditions (stable base versus moving base configuration). Synthesizing observations from the differing base configurations reduces the influence of sidewall friction because the force vector produced by sidewall friction points in opposite directions depending on whether the base is fixed or moving. With the numerical simulations, we calculate the energy budget at two stages of accretion: at the maximum force preceding the development of the first thrust pair, and at the minimum force following the development of the pair. To identify the appropriate combination of material and fault properties to apply in the simulations, we systematically vary the Young's modulus and the fault static and dynamic friction coefficients in numerical accretion simulations, and identify the set of parameters that minimizes the misfit between the normal force measured on the physical backwall and the numerically simulated force. Following this derivation of the appropriate material and fault properties, we calculate the components of the work budget in the numerical simulations and in the

  19. On the Critical Role of Divergent Selection in Evolvability

    Directory of Open Access Journals (Sweden)

    Joel Lehman

    2016-08-01

    Full Text Available An ambitious goal in evolutionary robotics is to evolve increasingly complex robotic behaviors with minimal human design effort. Reaching this goal requires evolutionary algorithms that can unlock from genetic encodings their latent potential for evolvability. One issue clouding this goal is conceptual confusion about evolvability, which often obscures the aspects of evolvability that are important or desirable. The danger from such confusion is that it may establish unrealistic goals for evolvability that prove unproductive in practice. An important issue separate from conceptual confusion is the common misalignment between selection and evolvability in evolutionary robotics. While more expressive encodings can represent higher-level adaptations (e.g. sexual reproduction or developmental systems that increase long-term evolutionary potential (i.e. evolvability, realizing such potential requires gradients of fitness and evolvability to align. In other words, selection is often a critical factor limiting increasing evolvability. Thus, drawing from a series of recent papers, this article seeks to both (1 clarify and focus the ways in which the term evolvability is used within artificial evolution, and (2 argue for the importance of one type of selection, i.e. divergent selection, for enabling evolvability. The main argument is that there is a fundamental connection between divergent selection and evolvability (on both the individual and population level that does not hold for typical goal-oriented selection. The conclusion is that selection pressure plays a critical role in realizing the potential for evolvability, and that divergent selection in particular provides a principled mechanism for encouraging evolvability in artificial evolution.

  20. How does cognition evolve? Phylogenetic comparative psychology

    Science.gov (United States)

    Matthews, Luke J.; Hare, Brian A.; Nunn, Charles L.; Anderson, Rindy C.; Aureli, Filippo; Brannon, Elizabeth M.; Call, Josep; Drea, Christine M.; Emery, Nathan J.; Haun, Daniel B. M.; Herrmann, Esther; Jacobs, Lucia F.; Platt, Michael L.; Rosati, Alexandra G.; Sandel, Aaron A.; Schroepfer, Kara K.; Seed, Amanda M.; Tan, Jingzhi; van Schaik, Carel P.; Wobber, Victoria

    2014-01-01

    Now more than ever animal studies have the potential to test hypotheses regarding how cognition evolves. Comparative psychologists have developed new techniques to probe the cognitive mechanisms underlying animal behavior, and they have become increasingly skillful at adapting methodologies to test multiple species. Meanwhile, evolutionary biologists have generated quantitative approaches to investigate the phylogenetic distribution and function of phenotypic traits, including cognition. In particular, phylogenetic methods can quantitatively (1) test whether specific cognitive abilities are correlated with life history (e.g., lifespan), morphology (e.g., brain size), or socio-ecological variables (e.g., social system), (2) measure how strongly phylogenetic relatedness predicts the distribution of cognitive skills across species, and (3) estimate the ancestral state of a given cognitive trait using measures of cognitive performance from extant species. Phylogenetic methods can also be used to guide the selection of species comparisons that offer the strongest tests of a priori predictions of cognitive evolutionary hypotheses (i.e., phylogenetic targeting). Here, we explain how an integration of comparative psychology and evolutionary biology will answer a host of questions regarding the phylogenetic distribution and history of cognitive traits, as well as the evolutionary processes that drove their evolution. PMID:21927850

  1. Approximating centrality in evolving graphs: toward sublinearity

    Science.gov (United States)

    Priest, Benjamin W.; Cybenko, George

    2017-05-01

    The identification of important nodes is a ubiquitous problem in the analysis of social networks. Centrality indices (such as degree centrality, closeness centrality, betweenness centrality, PageRank, and others) are used across many domains to accomplish this task. However, the computation of such indices is expensive on large graphs. Moreover, evolving graphs are becoming increasingly important in many applications. It is therefore desirable to develop on-line algorithms that can approximate centrality measures using memory sublinear in the size of the graph. We discuss the challenges facing the semi-streaming computation of many centrality indices. In particular, we apply recent advances in the streaming and sketching literature to provide a preliminary streaming approximation algorithm for degree centrality utilizing CountSketch and a multi-pass semi-streaming approximation algorithm for closeness centrality leveraging a spanner obtained through iteratively sketching the vertex-edge adjacency matrix. We also discuss possible ways forward for approximating betweenness centrality, as well as spectral measures of centrality. We provide a preliminary result using sketched low-rank approximations to approximate the output of the HITS algorithm.

  2. How does cognition evolve? Phylogenetic comparative psychology.

    Science.gov (United States)

    MacLean, Evan L; Matthews, Luke J; Hare, Brian A; Nunn, Charles L; Anderson, Rindy C; Aureli, Filippo; Brannon, Elizabeth M; Call, Josep; Drea, Christine M; Emery, Nathan J; Haun, Daniel B M; Herrmann, Esther; Jacobs, Lucia F; Platt, Michael L; Rosati, Alexandra G; Sandel, Aaron A; Schroepfer, Kara K; Seed, Amanda M; Tan, Jingzhi; van Schaik, Carel P; Wobber, Victoria

    2012-03-01

    Now more than ever animal studies have the potential to test hypotheses regarding how cognition evolves. Comparative psychologists have developed new techniques to probe the cognitive mechanisms underlying animal behavior, and they have become increasingly skillful at adapting methodologies to test multiple species. Meanwhile, evolutionary biologists have generated quantitative approaches to investigate the phylogenetic distribution and function of phenotypic traits, including cognition. In particular, phylogenetic methods can quantitatively (1) test whether specific cognitive abilities are correlated with life history (e.g., lifespan), morphology (e.g., brain size), or socio-ecological variables (e.g., social system), (2) measure how strongly phylogenetic relatedness predicts the distribution of cognitive skills across species, and (3) estimate the ancestral state of a given cognitive trait using measures of cognitive performance from extant species. Phylogenetic methods can also be used to guide the selection of species comparisons that offer the strongest tests of a priori predictions of cognitive evolutionary hypotheses (i.e., phylogenetic targeting). Here, we explain how an integration of comparative psychology and evolutionary biology will answer a host of questions regarding the phylogenetic distribution and history of cognitive traits, as well as the evolutionary processes that drove their evolution.

  3. On the Discovery of Evolving Truth.

    Science.gov (United States)

    Li, Yaliang; Li, Qi; Gao, Jing; Su, Lu; Zhao, Bo; Fan, Wei; Han, Jiawei

    2015-08-01

    In the era of big data, information regarding the same objects can be collected from increasingly more sources. Unfortunately, there usually exist conflicts among the information coming from different sources. To tackle this challenge, truth discovery, i.e., to integrate multi-source noisy information by estimating the reliability of each source, has emerged as a hot topic. In many real world applications, however, the information may come sequentially, and as a consequence, the truth of objects as well as the reliability of sources may be dynamically evolving. Existing truth discovery methods, unfortunately, cannot handle such scenarios. To address this problem, we investigate the temporal relations among both object truths and source reliability, and propose an incremental truth discovery framework that can dynamically update object truths and source weights upon the arrival of new data. Theoretical analysis is provided to show that the proposed method is guaranteed to converge at a fast rate. The experiments on three real world applications and a set of synthetic data demonstrate the advantages of the proposed method over state-of-the-art truth discovery methods.

  4. Sexual regret: evidence for evolved sex differences.

    Science.gov (United States)

    Galperin, Andrew; Haselton, Martie G; Frederick, David A; Poore, Joshua; von Hippel, William; Buss, David M; Gonzaga, Gian C

    2013-10-01

    Regret and anticipated regret enhance decision quality by helping people avoid making and repeating mistakes. Some of people's most intense regrets concern sexual decisions. We hypothesized evolved sex differences in women's and men's experiences of sexual regret. Because of women's higher obligatory costs of reproduction throughout evolutionary history, we hypothesized that sexual actions, particularly those involving casual sex, would be regretted more intensely by women than by men. In contrast, because missed sexual opportunities historically carried higher reproductive fitness costs for men than for women, we hypothesized that poorly chosen sexual inactions would be regretted more by men than by women. Across three studies (Ns = 200, 395, and 24,230), we tested these hypotheses using free responses, written scenarios, detailed checklists, and Internet sampling to achieve participant diversity, including diversity in sexual orientation. Across all data sources, results supported predicted psychological sex differences and these differences were localized in casual sex contexts. These findings are consistent with the notion that the psychology of sexual regret was shaped by recurrent sex differences in selection pressures operating over deep time.

  5. Extracting evolving pathologies via spectral clustering.

    Science.gov (United States)

    Bernardis, Elena; Pohl, Kilian M; Davatzikos, Christos

    2013-01-01

    A bottleneck in the analysis of longitudinal MR scans with white matter brain lesions is the temporally consistent segmentation of the pathology. We identify pathologies in 3D+t(ime) within a spectral graph clustering framework. Our clustering approach simultaneously segments and tracks the evolving lesions by identifying characteristic image patterns at each time-point and voxel correspondences across time-points. For each 3D image, our method constructs a graph where weights between nodes capture the likeliness of two voxels belonging to the same region. Based on these weights, we then establish rough correspondences between graph nodes at different time-points along estimated pathology evolution directions. We combine the graphs by aligning the weights to a reference time-point, thus integrating temporal information across the 3D images, and formulate the 3D+t segmentation problem as a binary partitioning of this graph. The resulting segmentation is very robust to local intensity fluctuations and yields better results than segmentations generated for each time-point.

  6. Functional Topology of Evolving Urban Drainage Networks

    Science.gov (United States)

    Yang, Soohyun; Paik, Kyungrock; McGrath, Gavan S.; Urich, Christian; Krueger, Elisabeth; Kumar, Praveen; Rao, P. Suresh C.

    2017-11-01

    We investigated the scaling and topology of engineered urban drainage networks (UDNs) in two cities, and further examined UDN evolution over decades. UDN scaling was analyzed using two power law scaling characteristics widely employed for river networks: (1) Hack's law of length (L)-area (A) [L∝Ah] and (2) exceedance probability distribution of upstream contributing area (δ) [P>(A≥δ>)˜aδ-ɛ]. For the smallest UDNs ((A≥δ>) plots for river networks are abruptly truncated, those for UDNs display exponential tempering [P>(A≥δ>)=aδ-ɛexp⁡>(-cδ>)]. The tempering parameter c decreases as the UDNs grow, implying that the distribution evolves in time to resemble those for river networks. However, the power law exponent ɛ for large UDNs tends to be greater than the range reported for river networks. Differences in generative processes and engineering design constraints contribute to observed differences in the evolution of UDNs and river networks, including subnet heterogeneity and nonrandom branching.

  7. The Evolving Classification of Pulmonary Hypertension.

    Science.gov (United States)

    Foshat, Michelle; Boroumand, Nahal

    2017-05-01

    - An explosion of information on pulmonary hypertension has occurred during the past few decades. The perception of this disease has shifted from purely clinical to incorporate new knowledge of the underlying pathology. This transfer has occurred in light of advancements in pathophysiology, histology, and molecular medical diagnostics. - To update readers about the evolving understanding of the etiology and pathogenesis of pulmonary hypertension and to demonstrate how pathology has shaped the current classification. - Information presented at the 5 World Symposia on pulmonary hypertension held since 1973, with the last meeting occurring in 2013, was used in this review. - Pulmonary hypertension represents a heterogeneous group of disorders that are differentiated based on differences in clinical, hemodynamic, and histopathologic features. Early concepts of pulmonary hypertension were largely influenced by pharmacotherapy, hemodynamic function, and clinical presentation of the disease. The initial nomenclature for pulmonary hypertension segregated the clinical classifications from pathologic subtypes. Major restructuring of this disease classification occurred between the first and second symposia, which was the first to unite clinical and pathologic information in the categorization scheme. Additional changes were introduced in subsequent meetings, particularly between the third and fourth World Symposia meetings, when additional pathophysiologic information was gained. Discoveries in molecular diagnostics significantly progressed the understanding of idiopathic pulmonary arterial hypertension. Continued advancements in imaging modalities, mechanistic pathogenicity, and molecular biomarkers will enable physicians to define pulmonary hypertension phenotypes based on the pathobiology and allow for treatment customization.

  8. Evolving application of biomimetic nanostructured hydroxyapatite

    Directory of Open Access Journals (Sweden)

    Norberto Roveri

    2010-11-01

    Full Text Available Norberto Roveri, Michele IafiscoLaboratory of Environmental and Biological Structural Chemistry (LEBSC, Dipartimento di Chimica ‘G. Ciamician’, Alma Mater Studiorum, Università di Bologna, Bologna, ItalyAbstract: By mimicking Nature, we can design and synthesize inorganic smart materials that are reactive to biological tissues. These smart materials can be utilized to design innovative third-generation biomaterials, which are able to not only optimize their interaction with biological tissues and environment, but also mimic biogenic materials in their functionalities. The biomedical applications involve increasing the biomimetic levels from chemical composition, structural organization, morphology, mechanical behavior, nanostructure, and bulk and surface chemical–physical properties until the surface becomes bioreactive and stimulates cellular materials. The chemical–physical characteristics of biogenic hydroxyapatites from bone and tooth have been described, in order to point out the elective sides, which are important to reproduce the design of a new biomimetic synthetic hydroxyapatite. This review outlines the evolving applications of biomimetic synthetic calcium phosphates, details the main characteristics of bone and tooth, where the calcium phosphates are present, and discusses the chemical–physical characteristics of biomimetic calcium phosphates, methods of synthesizing them, and some of their biomedical applications.Keywords: hydroxyapatite, nanocrystals, biomimetism, biomaterials, drug delivery, remineralization

  9. Evolving application of biomimetic nanostructured hydroxyapatite.

    Science.gov (United States)

    Roveri, Norberto; Iafisco, Michele

    2010-11-09

    By mimicking Nature, we can design and synthesize inorganic smart materials that are reactive to biological tissues. These smart materials can be utilized to design innovative third-generation biomaterials, which are able to not only optimize their interaction with biological tissues and environment, but also mimic biogenic materials in their functionalities. The biomedical applications involve increasing the biomimetic levels from chemical composition, structural organization, morphology, mechanical behavior, nanostructure, and bulk and surface chemical-physical properties until the surface becomes bioreactive and stimulates cellular materials. The chemical-physical characteristics of biogenic hydroxyapatites from bone and tooth have been described, in order to point out the elective sides, which are important to reproduce the design of a new biomimetic synthetic hydroxyapatite. This review outlines the evolving applications of biomimetic synthetic calcium phosphates, details the main characteristics of bone and tooth, where the calcium phosphates are present, and discusses the chemical-physical characteristics of biomimetic calcium phosphates, methods of synthesizing them, and some of their biomedical applications.

  10. Orbital Decay in Binaries with Evolved Stars

    Science.gov (United States)

    Sun, Meng; Arras, Phil; Weinberg, Nevin N.; Troup, Nicholas; Majewski, Steven R.

    2018-01-01

    Two mechanisms are often invoked to explain tidal friction in binary systems. The ``dynamical tide” is the resonant excitation of internal gravity waves by the tide, and their subsequent damping by nonlinear fluid processes or thermal diffusion. The ``equilibrium tide” refers to non-resonant excitation of fluid motion in the star’s convection zone, with damping by interaction with the turbulent eddies. There have been numerous studies of these processes in main sequence stars, but less so on the subgiant and red giant branches. Motivated by the newly discovered close binary systems in the Apache Point Observatory Galactic Evolution Experiment (APOGEE-1), we have performed calculations of both the dynamical and equilibrium tide processes for stars over a range of mass as the star’s cease core hydrogen burning and evolve to shell burning. Even for stars which had a radiative core on the main sequence, the dynamical tide may have very large amplitude in the newly radiative core in post-main sequence, giving rise to wave breaking. The resulting large dynamical tide dissipation rate is compared to the equilibrium tide, and the range of secondary masses and orbital periods over which rapid orbital decay may occur will be discussed, as well as applications to close APOGEE binaries.

  11. UKAEA'S evolving contract philosophy

    Energy Technology Data Exchange (ETDEWEB)

    Nicol, R. D. [UK Atomic Energy Authority, UKAEA, Harwell, Oxfordshire (United Kingdom)

    2003-07-01

    The United Kingdom Atomic Energy Authority (UKAEA) has gone through fundamental change over the last ten years. At the heart of this change has been UKAEA's relationship with the contracting and supply market. This paper describes the way in which UKAEA actively developed the market to support the decommissioning programme, and how the approach to contracting has evolved as external pressures and demands have changed. UKAEA's pro-active approach to industry has greatly assisted the development of a healthy, competitive market for services supporting decommissioning in the UK. There have been difficult changes and many challenges along the way, and some retrenchment was necessary to meet regulatory requirements. Nevertheless, UKAEA has sustained a high level of competition - now measured in terms of competed spend as a proportion of competable spend - with annual out-turns consistently over 80%. The prime responsibility for market development will pass to the new Nuclear Decommissioning Authority (NDA) in 2005, as the owner, on behalf of the Government, of the UK's civil nuclear liabilities. The preparatory work for the NDA indicates that the principles established by UKAEA will be carried forward. (author)

  12. New science catalogs of UV sources from the GALEX sky surveys, matched to optical-IR surveys. Related science tools, models, and first results on the characterization of evolved Galactic stellar populations.

    Science.gov (United States)

    Bianchi, Luciana; Shiao, Bernie; Thilker, David; Barr, Robert; Girardi, Leo

    2018-01-01

    GUVcat is a new, expanded and improved catalog of Ultraviolet (UV) sources from the GALEX surveys (Bianchi et al. 2017, ApJ Suppl, 230, 24; arXiv:1704.05903). It contains 83million unique sources measured in FUV and NUV (duplicate measurements and rim artifacts removed) at AIS depth (about FUV colors to classify sources by astrophysical class, and to characterize classes of stellar sources to which UV data are uniquely sensitive, such as hot white dwarfs (WD), including elusive types of binaries. We compared the content of Galactic sources with Milky Way models, computed with different prescriptions. We also matched GUVcat with the first Gaia source and Gaia TGAS releases, which add precise position and G-band photometry for the bright sources, and direct distance measurements for a few very bright sources. GALEX spectra are also available and included in the analysis. Follow-up observations with HST are ongoing for an exploratory subsample.The source catalogs and related tools are available from the uvsky web site http://dolomiti.pha.jhu.edu/uvsky/#GUVcat . GUVcat_AIS is also available from MAST casjobs and soon from Vizier. A useful tool for calculating the effective area coverage of GUVcat, and of the matched catalogs, in user-chosen regions of the sky, is also available at the above url.Acknowledgements: Partial support for this work was provided by NASA grants: NNX16AF40G, NNX14AF88G, HST-GO-14119.001

  13. The System Dynamics Analysis on the Evolvement of Mechanism of Convention and Exhibition Industry

    Science.gov (United States)

    Wu, Xin-Ju; Sun, Ming-Jun

    The purpose of this paper is to defines the factors and the way which influence the evolvement of convention and exhibition industry cluster (CEIC for short). From the perspective of system dynamics, the author designed the system flow chart and SD Model to show how the different factors exert positive/negative influencing on the CEIC. The author used Vensim to stimulate the SD Model and to verify its validity and application value. The research shows the evolvement of CEIC is the result of combined strength which comes from both the external and the internal system, the supply factors of the internal system and the market demand from the external system are key strengths for the evolvement of CEIC system. The model had a high fitting precision and a good predicting ability .The research can be used practically and theoretically for the development of convention and exhibition industry (C&E industry for short).

  14. Evolving Spiking Neural Networks for Control of Artificial Creatures

    Directory of Open Access Journals (Sweden)

    Arash Ahmadi

    2013-10-01

    Full Text Available To understand and analysis behavior of complicated and intelligent organisms, scientists apply bio-inspired concepts including evolution and learning to mathematical models and analyses. Researchers utilize these perceptions in different applications, searching for improved methods andapproaches for modern computational systems. This paper presents a genetic algorithm based evolution framework in which Spiking Neural Network (SNN of artificial creatures are evolved for higher chance of survival in a virtual environment. The artificial creatures are composed ofrandomly connected Izhikevich spiking reservoir neural networks using population activity rate coding. Inspired by biological neurons, the neuronal connections are considered with different axonal conduction delays. Simulations results prove that the evolutionary algorithm has thecapability to find or synthesis artificial creatures which can survive in the environment successfully.

  15. Evolving ATLAS Computing For Today’s Networks

    CERN Document Server

    Campana, S; The ATLAS collaboration; Jezequel, S; Negri, G; Serfon, C; Ueda, I

    2012-01-01

    The ATLAS computing infrastructure was designed many years ago based on the assumption of rather limited network connectivity between computing centres. ATLAS sites have been organized in a hierarchical model, where only a static subset of all possible network links can be exploited and a static subset of well connected sites (CERN and the T1s) can cover important functional roles such as hosting master copies of the data. The pragmatic adoption of such simplified approach, in respect of a more relaxed scenario interconnecting all sites, was very beneficial during the commissioning of the ATLAS distributed computing system and essential in reducing the operational cost during the first two years of LHC data taking. In the mean time, networks evolved far beyond this initial scenario: while a few countries are still poorly connected with the rest of the WLCG infrastructure, most of the ATLAS computing centres are now efficiently interlinked. Our operational experience in running the computing infrastructure in ...

  16. Interaction of methanol with the oxygen-evolving complex: atomistic models, channel identification, species dependence, and mechanistic implications† †Electronic supplementary information (ESI) available: Additional geometric and energetic data, sequence alignments, and Cartesian coordinates of all models. See DOI: 10.1039/c6sc02340a Click here for additional data file.

    Science.gov (United States)

    Retegan, Marius

    2016-01-01

    Methanol has long being used as a substrate analogue to probe access pathways and investigate water delivery at the oxygen-evolving complex (OEC) of photosystem-II. In this contribution we study the interaction of methanol with the OEC by assembling available spectroscopic data into a quantum mechanical treatment that takes into account the local channel architecture of the active site. The effect on the magnetic energy levels of the Mn4Ca cluster in the S2 state of the catalytic cycle can be explained equally well by two models that involve either methanol binding to the calcium ion of the cluster, or a second-sphere interaction in the vicinity of the “dangler” Mn4 ion. However, consideration of the latest 13C hyperfine interaction data shows that only one model is fully consistent with experiment. In contrast to previous hypotheses, methanol is not a direct ligand to the OEC, but is situated at the end-point of a water channel associated with the O4 bridge. Its effect on magnetic properties of plant PS-II results from disruption of hydrogen bonding between O4 and proximal channel water molecules, thus enhancing superexchange (antiferromagnetic coupling) between the Mn3 and Mn4 ions. The same interaction mode applies to the dark-stable S1 state and possibly to all other states of the complex. Comparison of protein sequences from cyanobacteria and plants reveals a channel-altering substitution (D1-Asn87 versus D1-Ala87) in the proximity of the methanol binding pocket, explaining the species-dependence of the methanol effect. The water channel established as the methanol access pathway is the same that delivers ammonia to the Mn4 ion, supporting the notion that this is the only directly solvent-accessible manganese site of the OEC. The results support the pivot mechanism for water binding at a component of the S3 state and would be consistent with partial inhibition of water delivery by methanol. Mechanistic implications for enzymatic regulation and catalytic

  17. Quantum mechanics in an evolving Hilbert space

    Science.gov (United States)

    Artacho, Emilio; O'Regan, David D.

    2017-03-01

    Many basis sets for electronic structure calculations evolve with varying external parameters, such as moving atoms in dynamic simulations, giving rise to extra derivative terms in the dynamical equations. Here we revisit these derivatives in the context of differential geometry, thereby obtaining a more transparent formalization, and a geometrical perspective for better understanding the resulting equations. The effect of the evolution of the basis set within the spanned Hilbert space separates explicitly from the effect of the turning of the space itself when moving in parameter space, as the tangent space turns when moving in a curved space. New insights are obtained using familiar concepts in that context such as the Riemann curvature. The differential geometry is not strictly that for curved spaces as in general relativity, a more adequate mathematical framework being provided by fiber bundles. The language used here, however, will be restricted to tensors and basic quantum mechanics. The local gauge implied by a smoothly varying basis set readily connects with Berry's formalism for geometric phases. Generalized expressions for the Berry connection and curvature are obtained for a parameter-dependent occupied Hilbert space spanned by nonorthogonal Wannier functions. The formalism is applicable to basis sets made of atomic-like orbitals and also more adaptative moving basis functions (such as in methods using Wannier functions as intermediate or support bases), but should also apply to other situations in which nonorthogonal functions or related projectors should arise. The formalism is applied to the time-dependent quantum evolution of electrons for moving atoms. The geometric insights provided here allow us to propose new finite-difference time integrators, and also better understand those already proposed.

  18. The evolving role of tiotropium in asthma

    Directory of Open Access Journals (Sweden)

    McIvor ER

    2017-08-01

    Full Text Available Emma R McIvor,1 R Andrew McIvor2 1Queen’s University, Belfast, UK; 2Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario, Canada Abstract: Tiotropium is a long-acting muscarinic antagonist (LAMA that exerts its bronchodilatory effect by blocking endogenous acetylcholine receptors in the airways. Its safety and efficacy are well established for the treatment of COPD, and it is now being recognized for its role in improving lung function and control in asthma. This review discusses the evolving role of tiotropium delivered by the Respimat® in patients across the range of asthma severities and ages, and provides an overview of safety and efficacy data. Tiotropium is the only LAMA currently approved for the treatment of asthma, and evidence from a large-scale clinical trial program, including several Phase III studies in adults, has demonstrated that tiotropium improves lung function and asthma control, with a safety profile comparable with that of placebo. Clinical trials in adolescent patients (aged 12–17 years have also shown improvements in lung function and trends toward improved asthma control. Of note, the efficacy and safety profiles are consistent regardless of baseline characteristics and phenotype. Given the large and growing body of evidence, it is likely that as clinical experience with tiotropium increases, this treatment may possibly emerge as the key choice for add-on therapy to inhaled corticosteroids/long-acting β2-agonists, and in patients who do not tolerate long-acting bronchodilators or other medications, in the future. Keywords: tiotropium, anticholinergics, asthma, efficacy

  19. Evolvable Cryogenics (ECRYO) Pressure Transducer Calibration Test

    Science.gov (United States)

    Diaz, Carlos E., Jr.

    2015-01-01

    This paper provides a summary of the findings of recent activities conducted by Marshall Space Flight Center's (MSFC) In-Space Propulsion Branch and MSFC's Metrology and Calibration Lab to assess the performance of current "state of the art" pressure transducers for use in long duration storage and transfer of cryogenic propellants. A brief historical narrative in this paper describes the Evolvable Cryogenics program and the relevance of these activities to the program. This paper also provides a review of three separate test activities performed throughout this effort, including: (1) the calibration of several pressure transducer designs in a liquid nitrogen cryogenic environmental chamber, (2) the calibration of a pressure transducer in a liquid helium Dewar, and (3) the calibration of several pressure transducers at temperatures ranging from 20 to 70 degrees Kelvin (K) using a "cryostat" environmental chamber. These three separate test activities allowed for study of the sensors along a temperature range from 4 to 300 K. The combined data shows that both the slope and intercept of the sensor's calibration curve vary as a function of temperature. This homogeneous function is contrary to the linearly decreasing relationship assumed at the start of this investigation. Consequently, the data demonstrates the need for lookup tables to change the slope and intercept used by any data acquisition system. This ultimately would allow for more accurate pressure measurements at the desired temperature range. This paper concludes with a review of a request for information (RFI) survey conducted amongst different suppliers to determine the availability of current "state of the art" flight-qualified pressure transducers. The survey identifies requirements that are most difficult for the suppliers to meet, most notably the capability to validate the sensor's performance at temperatures below 70 K.

  20. The 0.3-30 Kev Spectra Of Powerful Starburst Galaxies: Nustar And Chandra Observations Of Ngc 3256 And Ngc 3310

    DEFF Research Database (Denmark)

    Lehmer, B. D.; Tyler, J. B.; Hornschemeier, A. E.

    2015-01-01

    We present nearly simultaneous Chandra and NuSTAR observations of two actively star-forming galaxies within 50 Mpc: NGC 3256 and NGC 3310. Both galaxies are significantly detected by both Chandra and NuSTAR, which together provide the first-ever spectra of these two galaxies spanning 0.3-30 ke...... with equivalent measurements for nearby star-forming galaxies M83 and NGC 253, we analyze the star formation rate (SFR) normalized spectra of these starburst galaxies. The spectra of all four galaxies show sharply declining power-law slopes at energies above 3-6 keV primarily due to ULX populations. Our......-Eddington accreting ULXs that have been studied individually in a targeted NuSTAR ULX program. We also find that NGC 3310 exhibits a factor of ≈3-10 elevation of X-ray emission over the other star-forming galaxies due to a corresponding overabundance of ULXs. We argue that the excess of ULXs in NGC 3310 is most...

  1. Orthogonally Evolved AI to Improve Difficulty Adjustment in Video Games

    DEFF Research Database (Denmark)

    Hintze, Arend; Olson, Randal; Lehman, Joel Anthony

    2016-01-01

    (i.e. agents subject to fewer generations of evolution) make for easier opponents, while highly-evolved agents are more challenging to overcome. In this publication we test a new approach for difficulty adjustment in games: orthogonally evolved AI, where the player receives support from collaborating...... opponents. Furthermore, human interaction can modulate (and be informed by) the performance and behavior of collaborating agents. In this way, orthogonally evolved AI both facilitates smoother difficulty adjustment and enables new game experiences....

  2. Revealing the ISM in high redshift starburst galaxies: An analysis of Herschel PACS and SPIRE FTS spectroscopic observations of HerMES and H-ATLAS-selected lensed galaxies

    Science.gov (United States)

    Cooray, Asantha

    In the quest to develop a fundamental understanding of galaxy formation and evolution, observations of dusty star-forming galaxies (DSFGs) promise significant progress this decade. The importance of DSFGs is highlighted by the fact that half of the energy emitted by extragalactic sources emerges as dust-reprocessed light at infrared (IR) to sub millimeter wavelength. In the post-herschel\\ era, we are now at a unique position to tackle some of the key questions on galaxy formation and evolution because of the large area Herschel's Key Project surveys (HerMES and H-ATLAS). In particular those surveys have allowed us to identify a sample of 250 strongly gravitationally lensed DSFGs at z > 1. They give us a unique opportunity to dissect the detailed structures and kinematics of DSFGs. The Herschel Science Archive also contains individual follow up data on 44 and 25 of the brightest sources with SPIRE-FTS and PACS, respectively, in the spectroscopy mode, taking over 250 hours in four open-time programs. Only one of the 44 SPIRE FTS targets has yet to appear in the published literature. One of the four include an open-time 2 PACS spectroscopy program that was led at UCI by a former postdoc from the PI's group. That program was initially approved at Priority 2 in 2011, but was triggered in late 2012 and achieved 100% completion during the last two weeks of Herschel lifetime in May 2013. This archival analysis, interpretation, and modeling program involves two parts: (i) PACS spectroscopy in 50 to 200 microns of 25 lensed galaxies in the fine-structure emission lines [SiII]34, [SIII]33, [OIV]26, [OIII]52, [NIII]57 and [OI]63, and the molecular hydrogen H_2 S(0) and S(1). (ii) SPIRE FTS spectroscopy of 44 lensed galaxies, including above 25, over the wavelength range of 200 to 600 microns targeting [CII]158, [OIII]88, [OI]63/145, and [NI]122. The analysis will lead to a better understanding of the ISM of starbursting galaxies that span 1 z generation astrophysicists in the

  3. Creative Exchange: An Evolving Model of Multidisciplinary Collaboration

    Science.gov (United States)

    Fleischmann, Katja; Hutchison, Clive

    2012-01-01

    Often the traditional creative arts curriculum does not sufficiently respond to, nor reflect, contemporary work practice. Multidisciplinary teams are now increasingly the norm in creative arts practice especially when driven by technological innovation. Drawing on contemporary research that centres on the benefits of multidisciplinary…

  4. Degree distribution of a new model for evolving networks

    Indian Academy of Sciences (India)

    ution, P(k) ∼ exp(−k/m), where m is a constant. Empirical results demonstrate that many networks in nature appear to exhibit ... There are many examples where the distribution is neither power-law nor exponential, such ..... [13] Z Hou, X Kong, D Shi, G Chen and Q Zhao, cond-mat/09011418. [14] O Stolz, Vorlesungen uber ...

  5. Temporal and Evolving Data Warehouse Design

    Directory of Open Access Journals (Sweden)

    Sidra Faisal

    2017-01-01

    Full Text Available The data model of the classical data warehouse (formally, dimensional model does not offer comprehensive support for temporal data management. The underlying reason is that it requires consideration of several temporal aspects, which involve various time stamps. Also, transactional systems, which serves as a data source for data warehouse, have the tendency to change themselves due to changing business requirements. The classical dimensional model is deficient in handling changes to transaction sources. This has led to the development of various schemes, including evolution of data and evolution of data model and versioning of dimensional model. These models have their own strengths and limitations, but none fully satisfies the above-stated broad range of aspects, making it difficult to compare the proposed schemes with one another. This paper analyses the schemes that satisfy such challenging aspects faced by a data warehouse and proposes taxonomy for characterizing the existing models to temporal data management in data warehouse. The paper also discusses some open challenges.

  6. How People Interact in Evolving Online Affiliation Networks

    Directory of Open Access Journals (Sweden)

    Lazaros K. Gallos

    2012-08-01

    Full Text Available The study of human interactions is of central importance for understanding the behavior of individuals, groups, and societies. Here, we observe the formation and evolution of networks by monitoring the addition of all new links, and we analyze quantitatively the tendencies used to create ties in these evolving online affiliation networks. We show that an accurate estimation of these probabilistic tendencies can be achieved only by following the time evolution of the network. Inferences about the reason for the existence of links using statistical analysis of network snapshots must therefore be made with great caution. Here, we start by characterizing every single link when the tie was established in the network. This information allows us to describe the probabilistic tendencies of tie formation and extract meaningful sociological conclusions. We also find significant differences in behavioral traits in the social tendencies among individuals according to their degree of activity, gender, age, popularity, and other attributes. For instance, in the particular data sets analyzed here, we find that women reciprocate connections 3 times as much as men and that this difference increases with age. Men tend to connect with the most popular people more often than women do, across all ages. On the other hand, triangular tie tendencies are similar, independent of gender, and show an increase with age. These results require further validation in other social settings. Our findings can be useful to build models of realistic social network structures and to discover the underlying laws that govern establishment of ties in evolving social networks.

  7. Anomaly Detection in Time-Evolving Climate Graphs

    Science.gov (United States)

    Liess, S.; Agrawal, S.; Das, K.; Atluri, G.; Steinbach, M.; Steinhaeuser, K.; Kumar, V.

    2016-12-01

    The spatio­-temporal observations that are available for different climate variables such as pressure, temperature, wind, humidity etc., have been studied to understand how changes in one variable at a location exhibit similarity with changes in a different variable at a location thousands of kilometers away. These non-trivial long distance relationships, called teleconnections, are often useful in understanding the underlying physical phenomenon driving extreme events, which are becoming more common with the changing climate. Networks constructed using these data sets have the ability to capture these relationships at a global scale. These networks have been analyzed using a variety of network based approaches such as community detection and anomaly detection that have shown promise in capturing interesting climate phenomenon. In this research we plan to construct time-evolving climate networks such that their edges represent causal relationships, and then discover anomalies in such 'causal' climate networks. As part of this research, we will address several limitations of previous work in anomaly detection using climate networks. First, we will take into account spatial and temporal dependencies while constructing the networks, that has been largely ignored by existing work. Second, we will learn Granger causality to define causal relationships among different nodes. Third, we will build heterogeneous climate networks that will involve nodes from different climate variables. Fourth, we will construct a Granger graphical model to understand the long-range temporal dependency in the data. Finally, we will use community evolution based notion of anomaly detection on the time-evolving causal networks to discover deviations in expected behavior.

  8. Surface-effect corrections for oscillation frequencies of evolved stars

    Science.gov (United States)

    Ball, W. H.; Gizon, L.

    2017-04-01

    Context. Accurate modelling of solar-like oscillators requires that modelled mode frequencies are corrected for the systematic shift caused by improper modelling of the near-surface layers, known as the surface effect. Several parametrizations of the surface effect are now available but they have not yet been systematically compared with observations of stars showing modes with mixed g- and p-mode character. Aims: We investigate how much additional uncertainty is introduced to stellar model parameters by our uncertainty about the functional form of the surface effect. At the same time, we test whether any of the parametrizations is significantly better or worse at modelling observed subgiants and low-luminosity red giants. Methods: We model six stars observed by Kepler that show clear mixed modes. We fix the input physics of the stellar models and vary the choice of surface correction between five parametrizations. Results: Models using a solar-calibrated power law correction consistently fit the observations more poorly than the other four corrections. Models with the remaining four corrections generally fit the observations about equally well, with the combined surface correction by Ball & Gizon perhaps being marginally superior. The fits broadly agree on the model parameters within about the 2σ uncertainties, with discrepancies between the modified Lorentzian and free power law corrections occasionally exceeding the 3σ level. Relative to the best-fitting values, the total uncertainties on the masses, radii and ages of the stars are all less than 2, 1 and 6 per cent, respectively. Conclusions: A solar-calibrated power law, as formulated by Kjeldsen et al., appears unsuitable for use with more evolved solar-like oscillators. Among the remaining surface corrections, the uncertainty in the model parameters introduced by the surface effects is about twice as large as the uncertainty in the individual fits for these six stars. Though the fits are thus somewhat less

  9. Gap Gene Regulatory Dynamics Evolve along a Genotype Network

    Science.gov (United States)

    Crombach, Anton; Wotton, Karl R.; Jiménez-Guri, Eva; Jaeger, Johannes

    2016-01-01

    Developmental gene networks implement the dynamic regulatory mechanisms that pattern and shape the organism. Over evolutionary time, the wiring of these networks changes, yet the patterning outcome is often preserved, a phenomenon known as “system drift.” System drift is illustrated by the gap gene network—involved in segmental patterning—in dipteran insects. In the classic model organism Drosophila melanogaster and the nonmodel scuttle fly Megaselia abdita, early activation and placement of gap gene expression domains show significant quantitative differences, yet the final patterning output of the system is essentially identical in both species. In this detailed modeling analysis of system drift, we use gene circuits which are fit to quantitative gap gene expression data in M. abdita and compare them with an equivalent set of models from D. melanogaster. The results of this comparative analysis show precisely how compensatory regulatory mechanisms achieve equivalent final patterns in both species. We discuss the larger implications of the work in terms of “genotype networks” and the ways in which the structure of regulatory networks can influence patterns of evolutionary change (evolvability). PMID:26796549

  10. Emergence of segregation in evolving social networks.

    Science.gov (United States)

    Henry, Adam Douglas; Prałat, Paweł; Zhang, Cun-Quan

    2011-05-24

    In many social networks, there is a high correlation between the similarity of actors and the existence of relationships between them. This paper introduces a model of network evolution where actors are assumed to have a small aversion from being connected to others who are dissimilar to themselves, and yet no actor strictly prefers a segregated network. This model is motivated by Schelling's [Schelling TC (1969) Models of segregation. Am Econ Rev 59:488-493] classic model of residential segregation, and we show that Schelling's results also apply to the structure of networks; namely, segregated networks always emerge regardless of the level of aversion. In addition, we prove analytically that attribute similarity among connected network actors always reaches a stationary distribution, and this distribution is independent of network topology and the level of aversion bias. This research provides a basis for more complex models of social interaction that are driven in part by the underlying attributes of network actors and helps advance our understanding of why dysfunctional social network structures may emerge.

  11. Protein structural modularity and robustness are associated with evolvability.

    Science.gov (United States)

    Rorick, Mary M; Wagner, Günter P

    2011-01-01

    Theory suggests that biological modularity and robustness allow for maintenance of fitness under mutational change, and when this change is adaptive, for evolvability. Empirical demonstrations that these traits promote evolvability in nature remain scant however. This is in part because modularity, robustness, and evolvability are difficult to define and measure in real biological systems. Here, we address whether structural modularity and/or robustness confer evolvability at the level of proteins by looking for associations between indices of protein structural modularity, structural robustness, and evolvability. We propose a novel index for protein structural modularity: the number of regular secondary structure elements (helices and strands) divided by the number of residues in the structure. We index protein evolvability as the proportion of sites with evidence of being under positive selection multiplied by the average rate of adaptive evolution at these sites, and we measure this as an average over a phylogeny of 25 mammalian species. We use contact density as an index of protein designability, and thus, structural robustness. We find that protein evolvability is positively associated with structural modularity as well as structural robustness and that the effect of structural modularity on evolvability is independent of the structural robustness index. We interpret these associations to be the result of reduced constraints on amino acid substitutions in highly modular and robust protein structures, which results in faster adaptation through natural selection.

  12. Adaptation of Escherichia coli to glucose promotes evolvability in lactose.

    Science.gov (United States)

    Phillips, Kelly N; Castillo, Gerardo; Wünsche, Andrea; Cooper, Tim F

    2016-02-01

    The selective history of a population can influence its subsequent evolution, an effect known as historical contingency. We previously observed that five of six replicate populations that were evolved in a glucose-limited environment for 2000 generations, then switched to lactose for 1000 generations, had higher fitness increases in lactose than populations started directly from the ancestor. To test if selection in glucose systematically increased lactose evolvability, we started 12 replay populations--six from a population subsample and six from a single randomly selected clone--from each of the six glucose-evolved founder populations. These replay populations and 18 ancestral populations were evolved for 1000 generations in a lactose-limited environment. We found that replay populations were initially slightly less fit in lactose than the ancestor, but were more evolvable, in that they increased in fitness at a faster rate and to higher levels. This result indicates that evolution in the glucose environment resulted in genetic changes that increased the potential of genotypes to adapt to lactose. Genome sequencing identified four genes--iclR, nadR, spoT, and rbs--that were mutated in most glucose-evolved clones and are candidates for mediating increased evolvability. Our results demonstrate that short-term selective costs during selection in one environment can lead to changes in evolvability that confer longer term benefits. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

  13. Snapshots in X-ray binary evolution: Using Hα Emitters and post-starburst galaxies to study the age-dependence of XRB populations

    Science.gov (United States)

    Basu-Zych, Antara; Hornschemeier, Ann; Fragkos, Anastasios; Lehmer, Bret; Zezas, Andreas; Yukita, Mihoko; Tzanavaris, Panayiotis

    2018-01-01

    The X-ray emission in galaxies, due to X-ray binaries (XRBs), appears to depend on global galaxy properties such as stellar mass (M*), star formation rate (SFR), metallicity, and stellar age. This poster will present unique galaxy populations with well-defined stellar ages to test current relations and models. Specifically, Hα emitters (HAEs), which are nearby analogs of galaxies in the early universe, trace how XRBs form and evolve in young, metal-poor environments. We find that HAEs have lower X-ray luminosities per SFR and metallicity compared to other normal galaxies. At such young ages ( 500 Å), probe the XRB population related to stellar ages of 0.1-1 Gyr. At these ages, the donor star is expected to be an A-star whose mass is ~2 M⊙ and similar to that of the compact object, which may potentially lead to high mass transfer rates and high X-ray luminosities. Together, these samples offer important constraints for the evolution of XRBs with stellar age.

  14. Equation-free analysis of a dynamically evolving multigraph

    Science.gov (United States)

    Holiday, A.; Kevrekidis, I. G.

    2016-09-01

    In order to illustrate the adaptation of traditional continuum numerical techniques to the study of complex network systems, we use the equation-free framework to analyze a dynamically evolving multigraph. This approach is based on coupling short intervals of direct dynamic network simulation with appropriately-defined lifting and restriction operators, mapping the detailed network description to suitable macroscopic (coarse-grained) variables and back. This enables the acceleration of direct simulations through Coarse Projective Integration (CPI), as well as the identification of coarse stationary states via a Newton-GMRES method. We also demonstrate the use of data-mining, both linear (principal component analysis, PCA) and nonlinear (diffusion maps, DMAPS) to determine good macroscopic variables (observables) through which one can coarse-grain the model. These results suggest methods for decreasing simulation times of dynamic real-world systems such as epidemiological network models. Additionally, the data-mining techniques could be applied to a diverse class of problems to search for a succint, low-dimensional description of the system in a small number of variables.

  15. SPITZER MID-IR SPECTROSCOPY OF POWERFUL 2 JY AND 3CRR RADIO GALAXIES. I. EVIDENCE AGAINST A STRONG STARBURST-AGN CONNECTION IN RADIO-LOUD AGN

    Energy Technology Data Exchange (ETDEWEB)

    Dicken, D.; Axon, D.; Robinson, A.; Kharb, P. [Rochester Institute of Technology, 84 Lomb Memorial Drive, Rochester, NY 14623 (United States); Tadhunter, C.; Ramos Almeida, C. [Department of Physics and Astronomy University of Sheffield, Hounsfield Road, Sheffield, S3 7RH (United Kingdom); Morganti, R. [ASTRON, P.O. Box 2, 7990 AA Dwingeloo (Netherlands); Kouwenhoven, M. B. N. [Kavli Institute for Astronomy and Astrophysics, Peking University, Yi He Yuan Lu 5, Haidian Qu, Beijing 100871 (China); Spoon, H. [224 Space Sciences Building, Cornell University, Ithaca, NY 14853 (United States); Inskip, K. J. [Max Planck Institute for Astronomy, Koenigstuhl 17, 69117 Heidelberg (Germany); Holt, J. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA Leiden (Netherlands); Nesvadba, N. P. H., E-mail: daniel.dicken@ias.u-psud.fr [Institut d' Astrophysique Spatiale, CNRS, Universite Paris Sud, 91405 Orsay (France)

    2012-02-01

    We present deep Spitzer/Infrared Spectrograph (IRS) spectra for complete samples of 46 2 Jy radio galaxies (0.05 < z < 0.7) and 19 3CRR FRII radio galaxies (z < 0.1), and use the detection of polycyclic aromatic hydrocarbon (PAH) features to examine the incidence of contemporaneous star formation and radio-loud active galactic nucleus (AGN) activity. Our analysis reveals PAH features in only a minority (30%) of the objects with good IRS spectra. Using the wealth of complementary data available for the 2 Jy and 3CRR samples we make detailed comparisons between a range of star formation diagnostics: optical continuum spectroscopy, mid- to far-IR (MFIR) color, far-IR excess and PAH detection. There is good agreement between the various diagnostic techniques: most candidates identified to have star formation activity on the basis of PAH detection are also identified using at least two of the other techniques. We find that only 35% of the combined 2 Jy and 3CRR sample show evidence for recent star formation activity (RSFA) at optical and/or MFIR wavelengths. This result argues strongly against the idea of a close link between starburst and powerful radio-loud AGN activity, reinforcing the view that, although a large fraction of powerful radio galaxies may be triggered in galaxy interactions, only a minority are triggered at the peaks of star formation activity in major, gas-rich mergers. However, we find that compact radio sources (D < 15 kpc) show a significantly higher incidence of RSFA (>75%) than their more extended counterparts ( Almost-Equal-To 15%-25%). We discuss this result in the context of a possible bias toward the selection of compact radio sources triggered in gas-rich environments.

  16. Implications of a Culturally Evolved Self for Notions of Free Will

    Directory of Open Access Journals (Sweden)

    Lloyd Hawkeye Robertson

    2017-10-01

    Full Text Available Most schools in psychology have emphasized individual choice despite evidence of genetic and cultural determinism. It is suggested in this paper that the rejection of classical behaviorism by psychology and other humanities flowed from deeply held cultural assumptions about volition and free will. While compatibilists have suggested that notions of free will and determinism are not mutually exclusive, the psychological mechanisms by which such an accommodation could be explained have been inadequately explored. Drawing on research into classical cultures, this paper builds an argument that the notion of free will was adaptive flowing from culturally evolved changes to the self, and that this “evolved self,” containing assumptions of personal volition, continuity, and reason, became benchmarks of what it means to be human. The paper proposes a model of a culturally evolved self that is compatible with understandings of free will and determinism. Implications for therapeutic practice and future research are discussed.

  17. Implications of a Culturally Evolved Self for Notions of Free Will.

    Science.gov (United States)

    Robertson, Lloyd Hawkeye

    2017-01-01

    Most schools in psychology have emphasized individual choice despite evidence of genetic and cultural determinism. It is suggested in this paper that the rejection of classical behaviorism by psychology and other humanities flowed from deeply held cultural assumptions about volition and free will. While compatibilists have suggested that notions of free will and determinism are not mutually exclusive, the psychological mechanisms by which such an accommodation could be explained have been inadequately explored. Drawing on research into classical cultures, this paper builds an argument that the notion of free will was adaptive flowing from culturally evolved changes to the self, and that this "evolved self," containing assumptions of personal volition, continuity, and reason, became benchmarks of what it means to be human. The paper proposes a model of a culturally evolved self that is compatible with understandings of free will and determinism. Implications for therapeutic practice and future research are discussed.

  18. Food Addiction: An Evolving Nonlinear Science

    Science.gov (United States)

    Shriner, Richard; Gold, Mark

    2014-01-01

    The purpose of this review is to familiarize readers with the role that addiction plays in the formation and treatment of obesity, type 2 diabetes and disorders of eating. We will outline several useful models that integrate metabolism, addiction, and human relationship adaptations to eating. A special effort will be made to demonstrate how the use of simple and straightforward nonlinear models can and are being used to improve our knowledge and treatment of patients suffering from nutritional pathology. Moving forward, the reader should be able to incorporate some of the findings in this review into their own practice, research, teaching efforts or other interests in the fields of nutrition, diabetes, and/or bariatric (weight) management. PMID:25421535

  19. Food Addiction: An Evolving Nonlinear Science

    Directory of Open Access Journals (Sweden)

    Richard Shriner

    2014-11-01

    Full Text Available The purpose of this review is to familiarize readers with the role that addiction plays in the formation and treatment of obesity, type 2 diabetes and disorders of eating. We will outline several useful models that integrate metabolism, addiction, and human relationship adaptations to eating. A special effort will be made to demonstrate how the use of simple and straightforward nonlinear models can and are being used to improve our knowledge and treatment of patients suffering from nutritional pathology. Moving forward, the reader should be able to incorporate some of the findings in this review into their own practice, research, teaching efforts or other interests in the fields of nutrition, diabetes, and/or bariatric (weight management.

  20. Melanoma metastasis: new concepts and evolving paradigms.

    Science.gov (United States)

    Damsky, W E; Theodosakis, N; Bosenberg, M

    2014-05-08

    Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma metastasis are reviewed here and are incorporated into a comprehensive model for melanoma metastasis, which takes into account the varied natural history of melanoma formation and progression.

  1. NASA's Space Launch System: An Evolving Capability for Exploration An Evolving Capability for Exploration

    Science.gov (United States)

    Creech, Stephen D.; Crumbly, Christopher M.; Robinson, Kimerly F.

    2016-01-01

    A foundational capability for international human deep-space exploration, NASA's Space Launch System (SLS) vehicle represents a new spaceflight infrastructure asset, creating opportunities for mission profiles and space systems that cannot currently be executed. While the primary purpose of SLS, which is making rapid progress towards initial launch readiness in two years, will be to support NASA's Journey to Mars, discussions are already well underway regarding other potential utilization of the vehicle's unique capabilities. In its initial Block 1 configuration, capable of launching 70 metric tons (t) to low Earth orbit (LEO), SLS is capable of propelling the Orion crew vehicle to cislunar space, while also delivering small CubeSat-class spacecraft to deep-space destinations. With the addition of a more powerful upper stage, the Block 1B configuration of SLS will be able to deliver 105 t to LEO and enable more ambitious human missions into the proving ground of space. This configuration offers opportunities for launching co-manifested payloads with the Orion crew vehicle, and a class of secondary payloads, larger than today's CubeSats. Further upgrades to the vehicle, including advanced boosters, will evolve its performance to 130 t in its Block 2 configuration. Both Block 1B and Block 2 also offer the capability to carry 8.4- or 10-m payload fairings, larger than any contemporary launch vehicle. With unmatched mass-lift capability, payload volume, and C3, SLS not only enables spacecraft or mission designs currently impossible with contemporary EELVs, it also offers enhancing benefits, such as reduced risk, operational costs and/or complexity, shorter transit time to destination or launching large systems either monolithically or in fewer components. This paper will discuss both the performance and capabilities of Space Launch System as it evolves, and the current state of SLS utilization planning.

  2. Versatility of peroxisomes: An evolving concept.

    Science.gov (United States)

    Deb, Rachayeeta; Nagotu, Shirisha

    2017-04-01

    Research spanning almost 50 years has highlighted unique characteristics and irreplaceable list of diverse functions performed by peroxisomes in various model systems. Peroxisomes are single membrane bound highly dynamic organelles ubiquitous to most eukaryotic cells. Proliferation by division of pre-existing organelles and the role of endoplasmic reticulum in the biogenesis of these organelles is now well established. The earliest identified conserved functions of peroxisomes are β-oxidation of fatty acids and reactive oxygen species metabolism. Several studies over the last few decades have reported the importance of this organelle and its numerous cell type, tissue and environment-dependent functions. Their role in several aspects of human health and disease is now under investigation. Studies related to peroxisome biology and functions are now also extended to diverse model systems like Drosophila melanogaster, trypanosomatids, etc. Peroxisomes also intricately collaborate and carry out these functions together with several other organelles in a cell. In this review, we aim to present an overview of our current knowledge of the repertoire of functions of peroxisomes in various model systems. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Star formation in evolving molecular clouds

    Science.gov (United States)

    Völschow, M.; Banerjee, R.; Körtgen, B.

    2017-09-01

    Molecular clouds are the principle stellar nurseries of our universe; they thus remain a focus of both observational and theoretical studies. From observations, some of the key properties of molecular clouds are well known but many questions regarding their evolution and star formation activity remain open. While numerical simulations feature a large number and complexity of involved physical processes, this plethora of effects may hide the fundamentals that determine the evolution of molecular clouds and enable the formation of stars. Purely analytical models, on the other hand, tend to suffer from rough approximations or a lack of completeness, limiting their predictive power. In this paper, we present a model that incorporates central concepts of astrophysics as well as reliable results from recent simulations of molecular clouds and their evolutionary paths. Based on that, we construct a self-consistent semi-analytical framework that describes the formation, evolution, and star formation activity of molecular clouds, including a number of feedback effects to account for the complex processes inside those objects. The final equation system is solved numerically but at much lower computational expense than, for example, hydrodynamical descriptions of comparable systems. The model presented in this paper agrees well with a broad range of observational results, showing that molecular cloud evolution can be understood as an interplay between accretion, global collapse, star formation, and stellar feedback.

  4. Star Formation Modes in Low-Mass Disk Galaxies

    OpenAIRE

    Gallagher, J. S.; Matthews, L. D.

    2001-01-01

    Low-mass disk galaxies with well-organized structures are relatively common in low density regions of the nearby Universe. They display a wide range in levels of star formation activity, extending from sluggishly evolving `superthin' disk systems to nearby starbursts. Investigations of this class of galaxy therefore provides opportunities to test and define models of galactic star formation processes. In this paper we briefly explore characteristics of examples of quiescent and starbursting l...

  5. Evolving paradigm for fab revenue optimization

    Science.gov (United States)

    Akella, Ramakrishna; Fridgeirsdottir, Kristin; Skumanich, Andrew

    2002-07-01

    Historically for semiconductor processing, defects have been considered in a separate class as yield detractors and significant effort goes into detection, analysis and monitoring of defects. With the increase in complexity of nano technologies, defects now become a competent comprising only part of the overall picture of yield, or more importantly, of revenue. Given the acceleration decrease in feature sizes, there is a corresponding shift from emphasis on random defectivity to both systematical defectivity as well as parametric integrity. With the view that yield loss should be generalized to revenue loss of any type, it can then be understood that the notion of process monitoring generalizes to not just defect count, but also to be broader set of characteristic including device parameters. In this regards, the tool set for monitoring the process needs to be generalized to also include systematic and parametric inspection system. The model is that an inspection tool plus an associated algorithm is required for monitoring the variance in all critical elements. The fab must then optimize the set of tools and algorithms. Including integrated metrology tools in this optimization generalizes the revenue model further, but adds significant revenue enhancement opportunities. The issue and tradeoffs imply that the fabs must consider the full characterization needs in order to determine the proper mix of monitoring tools and algorithms.

  6. Exploring the making of a galactic wind in the star-bursting dwarf irregular galaxy IC 10 with LOFAR

    Science.gov (United States)

    Heesen, V.; Rafferty, D. A.; Horneffer, A.; Beck, R.; Basu, A.; Westcott, J.; Hindson, L.; Brinks, E.; ChyŻy, K. T.; Scaife, A. M. M.; Brüggen, M.; Heald, G.; Fletcher, A.; Horellou, C.; Tabatabaei, F. S.; Paladino, R.; Nikiel-Wroczyński, B.; Hoeft, M.; Dettmar, R.-J.

    2018-02-01

    Low-mass galaxies are subject to strong galactic outflows, in which cosmic rays may play an important role; they can be best traced with low-frequency radio continuum observations, which are less affected by spectral ageing. We present a study of the nearby star burst dwarf irregular galaxy IC 10 using observations at 140 MHz with the LOw-Frequency ARray (LOFAR), at 1580 MHz with the Very Large Array (VLA) and at 6200 MHz with the VLA and the 100-m Effelsberg telescope. We find that IC 10 has a low-frequency radio halo, which manifests itself as a second component (thick disc) in the minor axis profiles of the non-thermal radio continuum emission at 140 and 1580 MHz. These profiles are then fitted with 1D cosmic-ray transport models for pure diffusion and advection. We find that a diffusion model fits best, with a diffusion coefficient of D = (0.4-0.8) × 1026(E/GeV)0.5 cm2 s-1, which is at least an order of magnitude smaller than estimates both from anisotropic diffusion and the diffusion length. In contrast, advection models, which cannot be ruled out due to the mild inclination, while providing poorer fits, result in advection speeds close to the escape velocity of ≈50 km s^{-1}, as expected for a cosmic-ray driven wind. Our favoured model with an accelerating wind provides a self-consistent solution, where the magnetic field is in energy equipartition with both the warm neutral and warm ionized medium with an important contribution from cosmic rays. Consequently, cosmic rays can play a vital role for the launching of galactic winds in the disc-halo interface.

  7. Self-Evolvable Systems Machine Learning in Social Media

    CERN Document Server

    Iordache, Octavian

    2012-01-01

    This monograph presents key method to successfully manage the growing  complexity of systems  where conventional engineering and scientific methodologies and technologies based on learning and adaptability come to their limits and new ways are nowadays required. The transition from adaptable to evolvable and finally to self-evolvable systems is highlighted, self-properties such as self-organization, self-configuration, and self-repairing are introduced and challenges and limitations of the self-evolvable engineering systems are evaluated.

  8. Data Integration against Multiple Evolving Autonomous Schemata

    CERN Document Server

    Koch, Christoph

    Research in the area of data integration has resulted in approaches such as federated and multidatabases, mediation, data warehousing, global information systems, and the model management/schema matching approach. Architecturally, approaches can be categorized into those that integrate against a single global schema and those that do not, while on the level of inter-schema constraints, most work can be classied either as so-called global-as-view or as local-as-view integration. These approaches dier widely in their strengths and weaknesses. Federated databases have been found applicable in environments in which several autonomous information systems coexist { each with their individual schemata { and need to share data. However, this approach does not provide sucient support for dealing with change of schemata and requirements. Other approaches to data integration which are centered around a single \\global" integration schema, on the other hand, cannot handle design autonomy of information systems. Under evol...

  9. Evolving spacetimes with purely radial tension

    Directory of Open Access Journals (Sweden)

    B. Nasre Esfahani

    2000-12-01

    Full Text Available   In this study time-dependent and spherically symmetric solutions of the Einstein field equations in an anisotropic background with a purely radial tension are presented. There exist three classes of solutions,1 An open spacetime with a wormhole at its center. 2 A conical spacetime. 3 A closed spacetime. These inhomogeneous solutions are reduced to FRW spacetimes in matter-dominated era, asymptotically. Therefore, they can be used to describe local inhomogeneities that are not considered in the standard model. For the wormhole solution. it is explicity shown that the considered matter is non-exotic, that is, it does not violate the energy conditions. Also, static solutions are studied. There is only one static solution,a conical spacetime. In this case, the matter satisfies the energy condition critically.

  10. Diversity Generation in Evolving Microbial Populations

    DEFF Research Database (Denmark)

    Markussen, Trine

    to get a better understanding of how bacterial populations adapt to new, complex and heterogeneous environments with multiple selective pressures over long periods, and to analyse diversification during this adaptation. Using the P. aeruginosa chronic infection as a model system, and by combining...... bacterial genome sequencing, phenotypic profiling and unique sampling materials which included clonal bacterial isolates sampled for more than 4 decades from chronically infected CF patients, we were able to investigate the diversity generation of the clinical important and highly successful P. aeruginosa...... and maintenance of population diversity of infecting pathogens. Furthermore, fine-tuning of global regulatory networks by modification of transcriptional regulators has fundamental roles in successful adaptation of P. aeruginosa to the CF environment....

  11. Mesenchymal stromal cells: misconceptions and evolving concepts.

    Science.gov (United States)

    Phinney, Donald G; Sensebé, Luc

    2013-02-01

    Nearly half a century has passed since the publication of the first articles describing plastic-adherent cells from bone marrow, referred to initially as colony-forming unit fibroblasts, then marrow stromal cells, mesenchymal stem cells and most recently multipotent mesenchymal stromal cells (MSCs). As expected, our understanding of the nature and biologic functions of MSCs has undergone major paradigm shifts over this time. Despite significant advances made in deciphering their complex biology and therapeutic potential in both experimental animal models and human clinical trials, numerous misconceptions regarding the nature and function of MSCs have persisted in the field. Continued propagation of these misconceptions in some cases may significantly impede the advancement of MSC-based therapies in clinical medicine. We have identified six prevalent misconceptions about MSCs that we believe affect the field, and we attempt to rectify them based on current available data. Copyright © 2013 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  12. Collective properties of evolving molecular quasispecies

    Directory of Open Access Journals (Sweden)

    Manrubia Susanna C

    2007-07-01

    Full Text Available Abstract Background RNA molecules, through their dual appearance as sequence and structure, represent a suitable model to study evolutionary properties of quasispecies. The essential ingredient in this model is the differentiation between genotype (molecular sequences which are affected by mutation and phenotype (molecular structure, affected by selection. This framework allows a quantitative analysis of organizational properties of quasispecies as they adapt to different environments, such as their robustness, the effect of the degeneration of the sequence space, or the adaptation under different mutation rates and the error threshold associated. Results We describe and analyze the structural properties of molecular quasispecies adapting to different environments both during the transient time before adaptation takes place and in the asymptotic state, once optimization has occurred. We observe a minimum in the adaptation time at values of the mutation rate relatively far from the phenotypic error threshold. Through the definition of a consensus structure, it is shown that the quasispecies retains relevant structural information in a distributed fashion even above the error threshold. This structural robustness depends on the precise shape of the secondary structure used as target of selection. Experimental results available for natural RNA populations are in qualitative agreement with our observations. Conclusion Adaptation time of molecular quasispecies to a given environment is optimized at values of the mutation rate well below the phenotypic error threshold. The optimal value results from a trade-off between diversity generation and fixation of advantageous mutants. The critical value of the mutation rate is a function not only of the sequence length, but also of the specific properties of the environment, in this case the selection pressure and the shape of the secondary structure used as target phenotype. Certain functional motifs of RNA

  13. The Systems Biology Research Tool: evolvable open-source software.

    Science.gov (United States)

    Wright, Jeremiah; Wagner, Andreas

    2008-06-29

    Research in the field of systems biology requires software for a variety of purposes. Software must be used to store, retrieve, analyze, and sometimes even to collect the data obtained from system-level (often high-throughput) experiments. Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level. We introduce a free, easy-to-use, open-source, integrated software platform called the Systems Biology Research Tool (SBRT) to facilitate the computational aspects of systems biology. The SBRT currently performs 35 methods for analyzing stoichiometric networks and 16 methods from fields such as graph theory, geometry, algebra, and combinatorics. New computational techniques can be added to the SBRT via process plug-ins, providing a high degree of evolvability and a unifying framework for software development in systems biology. The Systems Biology Research Tool represents a technological advance for systems biology. This software can be used to make sophisticated computational techniques accessible to everyone (including those with no programming ability), to facilitate cooperation among researchers, and to expedite progress in the field of systems biology.

  14. Evolving Nonthermal Electrons in Simulations of Black Hole Accretion

    Science.gov (United States)

    Chael, Andrew; Narayan, Ramesh; Sadowski, Aleksander

    2017-06-01

    Current simulations of hot accretion flows around black holes assume either a single-temperature gas or, at best, a two-temperature gas with thermal ions and electrons. However, processes like magnetic reconnection and shocks can accelerate electrons into a nonthermal distribution, which will not quickly thermalise at the very low densities found in many systems. Such nonthermal electrons have been invoked to explain the infrared and X-ray spectra and strong variability of Sagittarius A* (Sgr A*), the black hole at the Galactic Center. We present a method for self-consistent evolution of a nonthermal electron population in the GRMHD code KORAL. The electron distribution is tracked across Lorentz factor space and is evolved in space and time, in parallel with thermal electrons, thermal ions, and radiation. At present, for simplicity, energy injection into the nonthermal distribution is taken as a fixed fraction of the local electron viscous heating rate. Numerical results are presented for a model with a low mass accretion rate similar to Sgr A*. We find that the presence of a nonthermal population of electrons has negligible effect on the overall dynamics of the system. Relative to a purely thermal simulation, the radiative power in the nonthermal simulation is enhanced at large radii and at high frequencies. The energy distribution of the nonthermal electrons shows a synchrotron cooling break, with the break Lorentz factor varying with location and time, reflecting the complex interplay between the local viscous heating rate, magnetic field strength, and fluid velocity.

  15. Evolving Nonthermal Electron Distributions in Simulations of Sgr A*

    Science.gov (United States)

    Chael, Andrew; Narayan, Ramesh

    2018-01-01

    The accretion flow around Sagittarius A* (Sgr A*), the black hole at the Galactic Center, produces strong variability from the radio to X-rays on timescales of minutes to hours. This rapid, powerful variability is thought to be powered by energetic particle acceleration by plasma processes like magnetic reconnection and shocks. These processes can accelerate particles into non-thermal distributions which do not quickly isothermal in the low densities found around hot accretion flows. Current state-of-the-art simulations of accretion flows around black holes assume either a single-temperature gas or, at best, a two-temperature gas with thermal ions and electrons. We present results from incorporating the self-consistent evolution of a non-thermal electron population in a GRRMHD simulation of Sgr A*. The electron distribution is evolved across space, time, and Lorentz factor in parallel with background thermal ion, electron, and radiation fluids. Energy injection into the non-thermal distribution is modeled with a sub-grid prescription based on results from particle-in-cell simulations of magnetic reconnection. The energy distribution of the non-thermal electrons shows strong variability, and the spectral shape traces the complex interplay between the local viscous heating rate, magnetic field strength, and fluid velocity. Results from these simulations will be used in interpreting forthcoming data from the Event Horizon Telescope that resolves Sgr A*'s sub-mm variability in both time and space.

  16. The evolved slowly pulsating B star 18 Peg

    Directory of Open Access Journals (Sweden)

    Irrgang Andreas

    2017-01-01

    Full Text Available The predicted width of the upper main sequence in stellar evolution models depends on the empirical calibration of the convective overshooting parameter. Despite decades of discussions, its precise value is still unknown and further observational constraints are required to gauge it. Irrgang et al. ([1] showed that the B3 III giant 18 Peg is one of the most evolved members of the class of slowly pulsating B (SPB stars and, thus, bears tremendous potential to derive a tight lower limit for the width of the upper main sequence. In addition, 18 Peg turns out to be part of a single-lined spectroscopic binary system with an eccentric, more than 6-year orbit. The orbital solution, in combination with the absence of additional signatures of the secondary component in the spectroscopic data and the spectral energy distribution, lead to the conclusion that all the observations of 18 Peg are fully compatible with the assumption that the secondary component is either a main-sequence star with a mass of 1-4 M⊙ or a neutron star.

  17. The Systems Biology Research Tool: evolvable open-source software

    Directory of Open Access Journals (Sweden)

    Wright Jeremiah

    2008-06-01

    Full Text Available Abstract Background Research in the field of systems biology requires software for a variety of purposes. Software must be used to store, retrieve, analyze, and sometimes even to collect the data obtained from system-level (often high-throughput experiments. Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level. Results We introduce a free, easy-to-use, open-source, integrated software platform called the Systems Biology Research Tool (SBRT to facilitate the computational aspects of systems biology. The SBRT currently performs 35 methods for analyzing stoichiometric networks and 16 methods from fields such as graph theory, geometry, algebra, and combinatorics. New computational techniques can be added to the SBRT via process plug-ins, providing a high degree of evolvability and a unifying framework for software development in systems biology. Conclusion The Systems Biology Research Tool represents a technological advance for systems biology. This software can be used to make sophisticated computational techniques accessible to everyone (including those with no programming ability, to facilitate cooperation among researchers, and to expedite progress in the field of systems biology.

  18. Recovery in New Zealand: an evolving concept?

    Science.gov (United States)

    O'Hagan, Mary; Reynolds, Paul; Smith, Cherryl

    2012-02-01

    Recovery was first officially promoted in New Zealand in 1998 and it became a key concept in mental health service development. Since the mid 2000s however, recovery has been on the wane in New Zealand, but the fundamental concepts within the term live on in two more recently adopted terms: whanau ora and well-being. He Korowai Oranga (Maori Health Strategy) defines whanau ora as families being supported to achieve health and well-being. The extended family is recognized as a source of strength, identity, security and support. Whanau ora is underpinned by Te Whare Tapa Wha, a well-being model that focuses on health being a balance between Taha Wairua (spiritual health), Taha Tinana (physical health), Taha Hinengaro (psychological health) and Taha Whānau (family health). New Zealanders are also using the term well-being, not just for the whole population but for people diagnosed with mental illness. The advantages of placing recovery into the larger well-being agenda are reduced discrimination and segregation of people with a diagnosis into a distinct population group, reduced association with medical and deficits approaches that can counter the recovery approach, and bypassing the dilution of the recovery approach that has occurred in traditional services.

  19. Evolving Perspectives on Lyme Borreliosis in Canada

    Science.gov (United States)

    Sperling, JLH; Middelveen, MJ; Klein, D; Sperling, FAH

    2012-01-01

    With cases now documented in every province, Lyme borreliosis (LB) is emerging as a serious public health risk in Canada. Controversy over the contribution of LB to the burden of chronic disease is maintained by difficulty in capturing accurate Canadian statistics, especially early clinical cases of LB. The use of dogs as sentinel species demon-strates that potential contact with Borrelia burgdorferi spirochetes, as detected by C6 peptide, extends across the country. Dissemination of infected ticks by migratory birds and rapid establishment of significant levels of infection have been well described. Canadian public health response has focused on identification of established populations of the tick vectors, Ixodes scapularis and I. pacificus, on the assumption that these are the only important vectors of the disease across Canada. Strains of B. burgdorferi circulating in Canada and the full range of their reservoir species and coinfections remain to be explored. Ongoing surveys and historical records demonstrate that Borrelia-positive Ixodes species are regu-larly present in regions of Canada that have previously been considered to be outside of the ranges of these species in re-cent modeling efforts. We present data demonstrating that human cases of LB are found across the nation. Consequently, physician education and better early diagnoses are needed to prevent long term sequelae. An international perspective will be paramount for developing improved Canadian guidelines that recognize the complexity and diversity of Lyme borreliosis. PMID:23091570

  20. Evolvement of French advanced practice nurses.

    Science.gov (United States)

    Bonnel, Galadriel

    2014-04-01

    The purpose of this review is to chronicle the development of the advanced practice nurse (APN) in France and compare international APN indictors of quality care with French studies. A review of the literature was performed by accessing the MEDLINE, Science Direct, and Cochrane Databases for studies of quality of care by APNs during 1965-2012. The author's participation on a national task force in collaboration with the French Ministry of Health provided additional information. After applying limits of this search, 36 studies fulfilled inclusion and exclusion criteria. In both the French and international APN nursing literature, the most frequently described quality of care measures were level of patient satisfaction and other patient outcomes (clinical and laboratory measures) according to evidence-based guidelines. In three French studies (nephrology, neuro-oncology, and urology settings), nurses performed direct patient care and were legally permitted to take on some limited responsibilities usually held by French physicians, including clinical examinations, diagnosing, and prescribing. Creation of the APN role in France can respond to public health challenges including the rising incidence of chronic diseases and an impending physician shortage. Future APN research should focus on rigorous, innovative design development including collaborative care models. ©2013 The Author(s) ©2013 American Association of Nurse Practitioners.

  1. Adapting Morphology to Multiple Tasks in Evolved Virtual Creatures

    DEFF Research Database (Denmark)

    Lessin, Dan; Fussell, Don; Miikkulainen, Risto

    2014-01-01

    The ESP method for evolving virtual creatures (Lessin et al., 2013) consisted of an encapsulation mechanism to preserve learned skills, a human-designed syllabus to build higherlevel skills by combining lower-level skills systematically, and a pandemonium mechanism to resolve conflicts between...... encapsulated skills in a single creature’s brain. Previous work with ESP showed that it is possible to evolve much more complex behavior than before, even when fundamental morphology (i.e., skeletal segments and joints) was evolved only for the first skill. This paper introduces a more general form of ESP...... in which full morphological development can continue beyond the first skill, allowing creatures to adapt their morphology to multiple tasks. This extension increases the variety and quality of evolved creature results significantly, while maintaining the original ESP system’s ability to incrementally...

  2. Orthogonally Evolved AI to Improve Difficulty Adjustment in Video Games

    DEFF Research Database (Denmark)

    Hintze, Arend; Olson, Randal; Lehman, Joel Anthony

    2016-01-01

    (i.e. agents subject to fewer generations of evolution) make for easier opponents, while highly-evolved agents are more challenging to overcome. In this publication we test a new approach for difficulty adjustment in games: orthogonally evolved AI, where the player receives support from collaborating...... agents that are co-evolved with opponent agents (where collaborators and opponents have orthogonal incentives). The advantage is that game difficulty can be adjusted more granularly by manipulating two independent axes: by having more or less adept collaborators, and by having more or less adept...... opponents. Furthermore, human interaction can modulate (and be informed by) the performance and behavior of collaborating agents. In this way, orthogonally evolved AI both facilitates smoother difficulty adjustment and enables new game experiences....

  3. Microbiota and diabetes: an evolving relationship.

    Science.gov (United States)

    Tilg, Herbert; Moschen, Alexander R

    2014-09-01

    The gut microbiota affects numerous biological functions throughout the body and its characterisation has become a major research area in biomedicine. Recent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular disease. Data are accumulating in animal models and humans suggesting that obesity and type 2 diabetes (T2D) are associated with a profound dysbiosis. First human metagenome-wide association studies demonstrated highly significant correlations of specific intestinal bacteria, certain bacterial genes and respective metabolic pathways with T2D. Importantly, especially butyrate-producing bacteria such as Roseburia intestinalis and Faecalibacterium prausnitzii concentrations were lower in T2D subjects. This supports the increasing evidence, that butyrate and other short-chain fatty acids are able to exert profound immunometabolic effects. Endotoxaemia, most likely gut-derived has also been observed in patients with metabolic syndrome and T2D and might play a key role in metabolic inflammation. A further hint towards an association between microbiota and T2D has been derived from studies in pregnancy showing that major gut microbial shifts occurring during pregnancy affect host metabolism. Interestingly, certain antidiabetic drugs such as metformin also interfere with the intestinal microbiota. Specific members of the microbiota such as Akkermansia muciniphila might be decreased in diabetes and when administered to murines exerted antidiabetic effects. Therefore, as a 'gut signature' becomes more evident in T2D, a better understanding of the role of the microbiota in diabetes might provide new aspects regarding its pathophysiological relevance and pave the way for new therapeutic principles. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  4. The Fundamental Plane of evolving red nuggets

    Science.gov (United States)

    Oldham, Lindsay; Auger, Matthew; Fassnacht, Christopher D.; Treu, Tommaso; Koopmans, L. V. E.; Lagattuta, David; McKean, John; Vegetti, Simona

    2017-09-01

    We present an exploration of the mass structure of a sample of 12 strongly lensed massive, compact early-type galaxies at redshifts z ∼ 0.6 to provide further possible evidence for their inside-out growth. We obtain new Echelette Spectrograph and Imager/Keck spectroscopy and infer the kinematics of both lens and source galaxies, and combine these with existing photometry to construct (a) the Fundamental Plane (FP) of the source galaxies and (b) physical models for their dark and luminous mass structure. We find their FP to be tilted towards the virial plane relative to the local FP, and attribute this to their unusual compactness, which causes their kinematics to be totally dominated by the stellar mass as opposed to their dark matter; that their FP is nevertheless still inconsistent with the virial plane implies that both the stellar and dark structure of early-type galaxies is non-homologous. We also find the intrinsic scatter of their FP to be comparable to the local value, indicating that variations in the stellar mass structure outweigh variations in the dark halo in the central regions of early-type galaxies. Finally, we show that inference on the dark halo structure - and, in turn, the underlying physics - is sensitive to assumptions about the stellar initial mass function (IMF), but that physically motivated assumptions about the IMF imply haloes with sub-Navarro-Frenk-White inner density slopes, and may present further evidence for the inside-out growth of compact early-type galaxies via minor mergers and accretion.

  5. Evolving the Evolving: Territory, Place and Rewilding in the California Delta

    Directory of Open Access Journals (Sweden)

    Brett Milligan

    2017-10-01

    Full Text Available Current planning and legislation in California’s Sacramento-San Joaquin Delta call for the large-scale ecological restoration of aquatic and terrestrial habitats. These ecological mandates have emerged in response to the region’s infrastructural transformation and the Delta’s predominant use as the central logistical hub in the state’s vast water conveyance network. Restoration is an attempt to recover what was externalized by the logic and abstractions of this logistical infrastructure. However, based on findings from our research, which examined how people are using restored and naturalized landscapes in the Delta and how these landscapes are currently planned for, we argue that as mitigatory response, restoration planning continues some of the same spatial abstractions and inequities by failing to account for the Delta as an urbanized, cultural and unique place. In interpreting how these conditions have come to be, we give attention to a pluralistic landscape approach and a coevolutionary reading of planning, policy, science and landscapes to discuss the conservation challenges presented by “Delta as an Evolving Place”. We suggest that for rewilding efforts to be successful in the Delta, a range of proactive, opportunistic, grounded and participatory tactics will be required to shift towards a more socio-ecological approach.

  6. Exploring the evolutionary mechanism of complex supply chain systems using evolving hypergraphs

    Science.gov (United States)

    Suo, Qi; Guo, Jin-Li; Sun, Shiwei; Liu, Han

    2018-01-01

    A new evolutionary model is proposed to describe the characteristics and evolution pattern of supply chain systems using evolving hypergraphs, in which nodes represent enterprise entities while hyperedges represent the relationships among diverse trades. The nodes arrive at the system in accordance with a Poisson process, with the evolving process incorporating the addition of new nodes, linking of old nodes, and rewiring of links. Grounded in the Poisson process theory and continuum theory, the stationary average hyperdegree distribution is shown to follow a shifted power law (SPL), and the theoretical predictions are consistent with the results of numerical simulations. Testing the impact of parameters on the model yields a positive correlation between hyperdegree and degree. The model also uncovers macro characteristics of the relationships among enterprises due to the microscopic interactions among individuals.

  7. How could the Gompertz-Makeham law evolve.

    Science.gov (United States)

    Golubev, A

    2009-05-07

    In line with the origin of life from the chemical world, biological mortality kinetics is suggested to originate from chemical decomposition kinetics described by the Arrhenius equation k = A*exp(-E/RT). Another chemical legacy of living bodies is that, by using the appropriate properties of their constituent molecules, they incorporate all their potencies, including adverse ones. In early evolution, acquiring an ability to use new molecules to increase disintegration barrier E might be associated with new adverse interactions, yielding products that might accumulate in organisms and compromise their viability. Thus, the main variable of the Arrhenius equation changed from T in chemistry to E in biology; mortality turned to rise exponentially as E declined with increasing age; and survivorship patterns turned to feature slow initial and fast late descent making the bulk of each finite cohort to expire within a short final period of its lifespan. Numerical modelling shows that such acquisition of new functions associated with faster functional decline may increase the efficiency of investing resources into progeny, in line with the antagonistic pleiotropy theory of ageing. Any evolved time trajectories of functional changes were translated into changes in mortality through exponent according to the generalised Gompertz-Makeham law mu = C(t)+Lambda*exp[-E(t)], which is reduced to the conventional form when E(t) = E0-gammat and C is constant. The proposed model explains the origin of the linear mid-age functional decline followed by its deceleration at later ages and the positive correlation between the initial vitality and the rate of ageing.

  8. Emergence of bursts and communities in evolving weighted networks.

    Science.gov (United States)

    Jo, Hang-Hyun; Pan, Raj Kumar; Kaski, Kimmo

    2011-01-01

    Understanding the patterns of human dynamics and social interaction and the way they lead to the formation of an organized and functional society are important issues especially for techno-social development. Addressing these issues of social networks has recently become possible through large scale data analysis of mobile phone call records, which has revealed the existence of modular or community structure with many links between nodes of the same community and relatively few links between nodes of different communities. The weights of links, e.g., the number of calls between two users, and the network topology are found correlated such that intra-community links are stronger compared to the weak inter-community links. This feature is known as Granovetter's "The strength of weak ties" hypothesis. In addition to this inhomogeneous community structure, the temporal patterns of human dynamics turn out to be inhomogeneous or bursty, characterized by the heavy tailed distribution of time interval between two consecutive events, i.e., inter-event time. In this paper, we study how the community structure and the bursty dynamics emerge together in a simple evolving weighted network model. The principal mechanisms behind these patterns are social interaction by cyclic closure, i.e., links to friends of friends and the focal closure, links to individuals sharing similar attributes or interests, and human dynamics by task handling process. These three mechanisms have been implemented as a network model with local attachment, global attachment, and priority-based queuing processes. By comprehensive numerical simulations we show that the interplay of these mechanisms leads to the emergence of heavy tailed inter-event time distribution and the evolution of Granovetter-type community structure. Moreover, the numerical results are found to be in qualitative agreement with empirical analysis results from mobile phone call dataset.

  9. Emergence of bursts and communities in evolving weighted networks.

    Directory of Open Access Journals (Sweden)

    Hang-Hyun Jo

    Full Text Available Understanding the patterns of human dynamics and social interaction and the way they lead to the formation of an organized and functional society are important issues especially for techno-social development. Addressing these issues of social networks has recently become possible through large scale data analysis of mobile phone call records, which has revealed the existence of modular or community structure with many links between nodes of the same community and relatively few links between nodes of different communities. The weights of links, e.g., the number of calls between two users, and the network topology are found correlated such that intra-community links are stronger compared to the weak inter-community links. This feature is known as Granovetter's "The strength of weak ties" hypothesis. In addition to this inhomogeneous community structure, the temporal patterns of human dynamics turn out to be inhomogeneous or bursty, characterized by the heavy tailed distribution of time interval between two consecutive events, i.e., inter-event time. In this paper, we study how the community structure and the bursty dynamics emerge together in a simple evolving weighted network model. The principal mechanisms behind these patterns are social interaction by cyclic closure, i.e., links to friends of friends and the focal closure, links to individuals sharing similar attributes or interests, and human dynamics by task handling process. These three mechanisms have been implemented as a network model with local attachment, global attachment, and priority-based queuing processes. By comprehensive numerical simulations we show that the interplay of these mechanisms leads to the emergence of heavy tailed inter-event time distribution and the evolution of Granovetter-type community structure. Moreover, the numerical results are found to be in qualitative agreement with empirical analysis results from mobile phone call dataset.

  10. Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome.

    Science.gov (United States)

    Kantarci, Orhun H; Lebrun, Christine; Siva, Aksel; Keegan, Mark B; Azevedo, Christina J; Inglese, Matilde; Tintoré, Mar; Newton, Braeden D; Durand-Dubief, Francoise; Amato, Maria Pia; De Stefano, Nicola; Sormani, Maria Pia; Pelletier, Daniel; Okuda, Darin T

    2016-02-01

    The aim of this work was to evaluate the preprogressive phase in subjects with radiologically isolated syndrome (RIS) who evolve to primary progressive multiple sclerosis (PPMS). A multicenter RIS cohort was previously established. Demographic, clinical, and radiological characteristics of subjects with RIS that evolved directly to PPMS were compared to those that developed a relapsing disease course from onset (clinically isolated syndrome [CIS] or relapsing-remitting MS) and were also compared to two other population- and clinic-based PPMS cohorts. Of the 453 subjects with RIS, 128 evolved to symptomatic MS during the follow-up (113 developed a first acute clinical event consistent with CIS/MS, 15 evolved to PPMS). PPMS prevalence (11.7%) and onset age (mean ± standard deviation; 49.1 ± 12.1) in the RIS group were comparable to other PPMS populations (p > 0.05). Median time to PPMS was 3.5 years (range, 1.6-5.4). RIS evolved to PPMS more commonly in men (p = 0.005) and at an older age (p < 0.001) when compared to CIS/MS, independent of follow-up duration. Subjects who evolved to PPMS had more spinal cord lesions (100%) before symptomatic evolution than those that developed CIS/MS (64%) and those that remained asymptomatic (23%) within the follow-up period (P = 0.005). Other MRI characteristics in the preprogressive phase of PPMS were indistinguishable from CIS/MS. Subjects with RIS evolve to PPMS at the same frequency as expected from general MS populations in an age-dependent manner. Besides age, unequivocal presence of spinal cord lesions and being male predicted evolution to PPMS. Our findings further suggest that RIS is biologically part of the MS spectrum. © 2015 American Neurological Association.

  11. Quantifying protein modularity and evolvability: a comparison of different techniques.

    Science.gov (United States)

    Rorick, Mary

    2012-10-01

    Modularity increases evolvability by reducing constraints on adaptation and by allowing preexisting parts to function in new contexts for novel uses. Protein evolution provides an excellent context to study the causes and consequences of biological modularity. In order to address such questions, however, an index for protein modularity is necessary. This paper proposes a simple index for protein modularity-"module density"-which is the number of evolutionarily independent modules that compose a protein divided by the number of amino acids in the protein. The decomposition of proteins into constituent modules can be accomplished by either of two classes of methods. The first class of methods relies on "suppositional" criteria to assign amino acids to modules, whereas the second class of methods relies on "coevolutionary" criteria for this task. One simple and practical method from the first class consists of approximating the number of modules in a protein as the number of regular secondary structure elements (i.e., helices and sheets). Methods based on coevolutionary criteria require more elaborate data, but they have the advantage of being able to specify modules without prior assumptions about why they exist. Given the increasing availability of datasets sampling protein mutational spectra (e.g., from comparative genomics, experimental evolution, and computational prediction), methods based on coevolutionary criteria will likely become more promising in the near future. The ability to meaningfully quantify protein modularity via simple indices has the potential to aid future efforts to understand protein evolutionary rate determinants, improve molecular evolution models and engineer novel proteins. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  12. Adoption of Geospatial Systems towards evolving Sustainable Himalayan Mountain Development

    Science.gov (United States)

    Murthy, M. S. R.; Bajracharya, B.; Pradhan, S.; Shestra, B.; Bajracharya, R.; Shakya, K.; Wesselmann, S.; Ali, M.; Bajracharya, S.; Pradhan, S.

    2014-11-01

    Natural resources dependence of mountain communities, rapid social and developmental changes, disaster proneness and climate change are conceived as the critical factors regulating sustainable Himalayan mountain development. The Himalayan region posed by typical geographic settings, diverse physical and cultural diversity present a formidable challenge to collect and manage data, information and understands varied socio-ecological settings. Recent advances in earth observation, near real-time data, in-situ measurements and in combination of information and communication technology have transformed the way we collect, process, and generate information and how we use such information for societal benefits. Glacier dynamics, land cover changes, disaster risk reduction systems, food security and ecosystem conservation are a few thematic areas where geospatial information and knowledge have significantly contributed to informed decision making systems over the region. The emergence and adoption of near-real time systems, unmanned aerial vehicles (UAV), board-scale citizen science (crowd-sourcing), mobile services and mapping, and cloud computing have paved the way towards developing automated environmental monitoring systems, enhanced scientific understanding of geophysical and biophysical processes, coupled management of socio-ecological systems and community based adaptation models tailored to mountain specific environment. There are differentiated capacities among the ICIMOD regional member countries with regard to utilization of earth observation and geospatial technologies. The region can greatly benefit from a coordinated and collaborative approach to capture the opportunities offered by earth observation and geospatial technologies. The regional level data sharing, knowledge exchange, and Himalayan GEO supporting geospatial platforms, spatial data infrastructure, unique region specific satellite systems to address trans-boundary challenges would go a long way in

  13. Sauropod dinosaurs evolved moderately sized genomes unrelated to body size.

    Science.gov (United States)

    Organ, Chris L; Brusatte, Stephen L; Stein, Koen

    2009-12-22

    Sauropodomorph dinosaurs include the largest land animals to have ever lived, some reaching up to 10 times the mass of an African elephant. Despite their status defining the upper range for body size in land animals, it remains unknown whether sauropodomorphs evolved larger-sized genomes than non-avian theropods, their sister taxon, or whether a relationship exists between genome size and body size in dinosaurs, two questions critical for understanding broad patterns of genome evolution in dinosaurs. Here we report inferences of genome size for 10 sauropodomorph taxa. The estimates are derived from a Bayesian phylogenetic generalized least squares approach that generates posterior distributions of regression models relating genome size to osteocyte lacunae volume in extant tetrapods. We estimate that the average genome size of sauropodomorphs was 2.02 pg (range of species means: 1.77-2.21 pg), a value in the upper range of extant birds (mean = 1.42 pg, range: 0.97-2.16 pg) and near the average for extant non-avian reptiles (mean = 2.24 pg, range: 1.05-5.44 pg). The results suggest that the variation in size and architecture of genomes in extinct dinosaurs was lower than the variation found in mammals. A substantial difference in genome size separates the two major clades within dinosaurs, Ornithischia (large genomes) and Saurischia (moderate to small genomes). We find no relationship between body size and estimated genome size in extinct dinosaurs, which suggests that neutral forces did not dominate the evolution of genome size in this group.

  14. High Dynamics Infrared Imaging of Evolved Stars with FLUOR/IOTA

    Science.gov (United States)

    Perrin, G.; Coudé du Foresto, V.; Ridgway, S. T.; Mariotti, J.-M.; Traub, W. A.; Carleton, N. P.; Lacasse, M. G.

    The high precision FLUOR beam combiner set on the IOTA interferometer allows a very accurate calibration of visibilities. As a consequence, it is very well suited to study surface structures and variations of evolved stars in the K band. We present data obtained on several stars showing departure from uniform and limb-darkened disk models and variations with time. Among them, surface features on the supergiant alpha Orionis and diameter variations of the Mira type star R Leonis.

  15. Evolving Systems: An Outcome of Fondest Hopes and Wildest Dreams

    Science.gov (United States)

    Frost, Susan A.; Balas, Mark J.

    2012-01-01

    New theory is presented for evolving systems, which are autonomously controlled subsystems that self-assemble into a new evolved system with a higher purpose. Evolving systems of aerospace structures often require additional control when assembling to maintain stability during the entire evolution process. This is the concept of Adaptive Key Component Control that operates through one specific component to maintain stability during the evolution. In addition, this control must often overcome persistent disturbances that occur while the evolution is in progress. Theoretical results will be presented for Adaptive Key Component control for persistent disturbance rejection. An illustrative example will demonstrate the Adaptive Key Component controller on a system composed of rigid body and flexible body modes.

  16. Study on evolving phases of accelerating generalized polygon beams.

    Science.gov (United States)

    Zhang, Yuntian; Dong, Fengliang; Qian, Kemao; Zhang, Qingchuan; Chu, Weiguo; Ma, Xuan; Wu, Xiaoping

    2016-03-07

    Recently, accelerating beam is becoming a hotspot in optics research. In this paper, we studied the evolving phases of accelerating generalized polygon beams (AGPBs) and proposed a novel method to generate this beam family. An important discovery has been made about reconstructing AGPBs only by evolving low-frequency phases in high power region, which confirms the dominant role of phase terms in the AGPBs' evolution. We also succeeded controlling the size and quantity of AGPB's intensity peaks in an easy and direct manner by manipulating the evolving phases in low frequency. This result not only explains the self-healing property of AGPBs but also confirms that AGPBs can be a great candidate to function as an optical tweezer to trap and free microparticles and microcreatures for certain purpose.

  17. Cosmic Biology How Life Could Evolve on Other Worlds

    CERN Document Server

    Irwin, Louis Neil

    2011-01-01

    It is very unlikely that little green humanoids are living on Mars. But what are the possible life forms that might exist in our Solar System and how might they have evolved? This uniquely authoritative and imaginative book on the possibilties for alien life addresses the intrinsic interest that we have about life on other worlds - reinforcing some of our assumptions and reshaping others. It introduces new possibilties that will enlarge our understanding of the issue overall, in particular the enormous range of environments and planetary conditions within which life might evolve. Cosmic Biology -discusses a broad range of possible environments where alien life might have evolved; -explains why carbon-based, water-borne life is more likely that its alternatives, but is not the only possiblity; -applies the principles of planetary science and modern biology to evolutionary scenarios on other worlds; -looks at the future fates of living systems, including those on Earth.

  18. Qualitative Functional Decomposition Analysis of Evolved Neuromorphic Flight Controllers

    Directory of Open Access Journals (Sweden)

    Sanjay K. Boddhu

    2012-01-01

    Full Text Available In the previous work, it was demonstrated that one can effectively employ CTRNN-EH (a neuromorphic variant of EH method methodology to evolve neuromorphic flight controllers for a flapping wing robot. This paper describes a novel frequency grouping-based analysis technique, developed to qualitatively decompose the evolved controllers into explainable functional control blocks. A summary of the previous work related to evolving flight controllers for two categories of the controller types, called autonomous and nonautonomous controllers, is provided, and the applicability of the newly developed decomposition analysis for both controller categories is demonstrated. Further, the paper concludes with appropriate discussion of ongoing work and implications for possible future work related to employing the CTRNN-EH methodology and the decomposition analysis techniques presented in this paper.

  19. Interactions, Starbursts, and Star Formation

    Directory of Open Access Journals (Sweden)

    Johan H. Knapen

    2015-12-01

    Full Text Available We study how interactions between galaxies affect star formation within them by considering a sample of almost 1500 of the nearest galaxies, all within a distance of ∼45 Mpc. We use the far-IR emission to define the massive star formation rate (SFR, and then normalise the SFR by the stellar mass of the galaxy to obtain the specific star formation rate (SSFR. We explore the distribution of (SSFR with morphological type and with stellar mass. We calculate the relative enhancement of SFR and SSFR for each galaxy by normalising them by the median SFR and SSFR values of individual control samples of similar non-interacting galaxies. We find that both the median SFR and SSFR are enhanced in interacting galaxies, and more so as the degree of interaction is higher. The increase is moderate, reaching a maximum of a factor of 1.9 for the highest degree of interaction (mergers. While the SFR and SSFR are enhanced statistically by interactions, in many individual interacting galaxies they are not enhanced at all. Our study is based on a representative sample of nearby galaxies and should be used to place constraints on studies based on samples of galaxies at larger distances.

  20. The cartography of pain: the evolving contribution of pain maps.

    Science.gov (United States)

    Schott, Geoffrey D

    2010-09-01

    Pain maps are nowadays widely used in clinical practice. This article aims to critically review the fundamental principles that underlie the mapping of pain, to analyse the evolving iconography of pain maps and their sometimes straightforward and sometimes contentious nature when used in the clinic, and to draw attention to some more recent developments in mapping pain. It is concluded that these maps are intriguing and evolving cartographic tools which can be used for depicting not only the spatial features but also the interpretative or perceptual components and accompaniments of pain. Copyright 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.

  1. 1. History, evolution, and evolving standards of contact lens care.

    Science.gov (United States)

    Szczotka-Flynn, Loretta; Ahearn, Donald G; Barr, Joseph; Benjamin, William Joe; Kiang, Tina; Nichols, Jason J; Schein, Oliver D; Stone, Ralph P; Winterton, Lynn

    2013-01-15

    Contact lenses and lens care regimens are an important part of eyecare practices and vital to lens-wearing patients. New contact lens materials and cleaning options continue to come to market and affect how patients wear and care for their lenses. In this section we look at how the contact lens and lens solution revolution started, how it has evolved over the last 40 years, and how standards have evolved and impacted these new offerings. Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  2. THE 0.3–30 keV SPECTRA OF POWERFUL STARBURST GALAXIES: NuSTAR AND CHANDRA OBSERVATIONS OF NGC 3256 AND NGC 3310

    Energy Technology Data Exchange (ETDEWEB)

    Lehmer, B. D.; Wik, D. R.; Yukita, M. [The Johns Hopkins University, Homewood Campus, Baltimore, MD 21218 (United States); Tyler, J. B.; Hornschemeier, A. E.; Ptak, A.; Zhang, W. W. [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States); Antoniou, V.; Zezas, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Boggs, S.; Craig, W. W. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Christensen, F. E. [DTU Space-National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Hailey, C. J. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Harrison, F. A. [Caltech Division of Physics, Mathematics and Astronomy, Pasadena (United States); Maccarone, T. J. [Department of Physics, Texas Tech University, Lubbock, TX 79409 (United States); Stern, D. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

    2015-06-10

    We present nearly simultaneous Chandra and NuSTAR observations of two actively star-forming galaxies within 50 Mpc: NGC 3256 and NGC 3310. Both galaxies are significantly detected by both Chandra and NuSTAR, which together provide the first-ever spectra of these two galaxies spanning 0.3–30 keV. The X-ray emission from both galaxies is spatially resolved by Chandra; we find that hot gas dominates the E < 1–3 keV emission while ultraluminous X-ray sources (ULXs) provide majority contributions to the emission at E > 1–3 keV. The NuSTAR galaxy-wide spectra of both galaxies follow steep power-law distributions with Γ ≈ 2.6 at E > 5–7 keV. Using new and archival Chandra data, we search for signatures of heavily obscured or low luminosity active galactic nuclei (AGNs). We find that both NGC 3256 and NGC 3310 have X-ray detected sources coincident with nuclear regions; however, the steep NuSTAR spectra of both galaxies restricts these sources to be either low luminosity AGNs (L{sub 2−10} {sub keV}/L{sub Edd} ≲ 10{sup −5}) or non-AGNs in nature (e.g., ULXs or crowded X-ray sources that reach L{sub 2−10} {sub keV} ∼ 10{sup 40} erg s{sup −1} cannot be ruled out). Combining our constraints on the 0.3–30 keV spectra of NGC 3256 and NGC 3310 with equivalent measurements for nearby star-forming galaxies M83 and NGC 253, we analyze the star formation rate (SFR) normalized spectra of these starburst galaxies. The spectra of all four galaxies show sharply declining power-law slopes at energies above 3–6 keV primarily due to ULX populations. Our observations therefore constrain the average spectral shape of galaxy-wide populations of luminous accreting binaries (i.e., ULXs). Interestingly, despite a completely different galaxy sample selection, emphasizing here a range of SFRs and stellar masses, these properties are similar to those of super-Eddington accreting ULXs that have been studied individually in a targeted NuSTAR ULX program. We also find that

  3. Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability.

    Directory of Open Access Journals (Sweden)

    Sam F Greenbury

    2016-03-01

    Full Text Available Mutational neighbourhoods in genotype-phenotype (GP maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should strongly influence evolutionary dynamics. We explore and quantify these intuitions by comparing three GP maps-a model for RNA secondary structure, the HP model for protein tertiary structure, and the Polyomino model for protein quaternary structure-to a simple random null model that maintains the number of genotypes mapping to each phenotype, but assigns genotypes randomly. The mutational neighbourhood of a genotype in these GP maps is much more likely to contain genotypes mapping to the same phenotype than in the random null model. Such neutral correlations can be quantified by the robustness to mutations, which can be many orders of magnitude larger than that of the null model, and crucially, above the critical threshold for the formation of large neutral networks of mutationally connected genotypes which enhance the capacity for the exploration of phenotypic novelty. Thus neutral correlations increase evolvability. We also study non-neutral correlations: Compared to the null model, i If a particular (non-neutral phenotype is found once in the 1-mutation neighbourhood of a genotype, then the chance of finding that phenotype multiple times in this neighbourhood is larger than expected; ii If two genotypes are connected by a single neutral mutation, then their respective non-neutral 1-mutation neighbourhoods are more likely to be similar; iii If a genotype maps to a folding or self-assembling phenotype, then its non-neutral neighbours are less likely to be a potentially deleterious non-folding or non-assembling phenotype. Non-neutral correlations of type i and ii reduce the rate at which new phenotypes can be found by neutral exploration, and so may diminish evolvability, while non-neutral correlations of type iii may instead facilitate evolutionary exploration

  4. Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability.

    Science.gov (United States)

    Greenbury, Sam F; Schaper, Steffen; Ahnert, Sebastian E; Louis, Ard A

    2016-03-01

    Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should strongly influence evolutionary dynamics. We explore and quantify these intuitions by comparing three GP maps-a model for RNA secondary structure, the HP model for protein tertiary structure, and the Polyomino model for protein quaternary structure-to a simple random null model that maintains the number of genotypes mapping to each phenotype, but assigns genotypes randomly. The mutational neighbourhood of a genotype in these GP maps is much more likely to contain genotypes mapping to the same phenotype than in the random null model. Such neutral correlations can be quantified by the robustness to mutations, which can be many orders of magnitude larger than that of the null model, and crucially, above the critical threshold for the formation of large neutral networks of mutationally connected genotypes which enhance the capacity for the exploration of phenotypic novelty. Thus neutral correlations increase evolvability. We also study non-neutral correlations: Compared to the null model, i) If a particular (non-neutral) phenotype is found once in the 1-mutation neighbourhood of a genotype, then the chance of finding that phenotype multiple times in this neighbourhood is larger than expected; ii) If two genotypes are connected by a single neutral mutation, then their respective non-neutral 1-mutation neighbourhoods are more likely to be similar; iii) If a genotype maps to a folding or self-assembling phenotype, then its non-neutral neighbours are less likely to be a potentially deleterious non-folding or non-assembling phenotype. Non-neutral correlations of type i) and ii) reduce the rate at which new phenotypes can be found by neutral exploration, and so may diminish evolvability, while non-neutral correlations of type iii) may instead facilitate evolutionary exploration and so

  5. Evolving matched filter transform pairs for satellite image processing

    Science.gov (United States)

    Peterson, Michael R.; Horner, Toby; Moore, Frank

    2011-06-01

    Wavelets provide an attractive method for efficient image compression. For transmission across noisy or bandwidth limited channels, a signal may be subjected to quantization in which the signal is transcribed onto a reduced alphabet in order to save bandwidth. Unfortunately, the performance of the discrete wavelet transform (DWT) degrades at increasing levels of quantization. In recent years, evolutionary algorithms (EAs) have been employed to optimize wavelet-inspired transform filters to improve compression performance in the presence of quantization. Wavelet filters consist of a pair of real-valued coefficient sets; one set represents the compression filter while the other set defines the image reconstruction filter. The reconstruction filter is defined as the biorthogonal inverse of the compression filter. Previous research focused upon two approaches to filter optimization. In one approach, the original wavelet filter is used for image compression while the reconstruction filter is evolved by an EA. In the second approach, both the compression and reconstruction filters are evolved. In both cases, the filters are not biorthogonally related to one another. We propose a novel approach to filter evolution. The EA optimizes a compression filter. Rather than using a wavelet filter or evolving a second filter for reconstruction, the reconstruction filter is computed as the biorthogonal inverse of the evolved compression filter. The resulting filter pair retains some of the mathematical properties of wavelets. This paper compares this new approach to existing filter optimization approaches to determine its suitability for the optimization of image filters appropriate for defense applications of image processing.

  6. Functional properties of the oxygen evolving complex of photosystem 2

    NARCIS (Netherlands)

    Vliet, van P.H.

    1996-01-01


    This Thesis presents the results of a study by electron paramagnetic resonance (EPR) and measurements of oxygen evolution of the Oxygen Evolving Complex of Photosystem 11 (PS-II) in PS-II enriched membranes from spinach.

    The experimental part of this Thesis is preceded by a

  7. Evolving fuzzy rules for relaxed-criteria negotiation.

    Science.gov (United States)

    Sim, Kwang Mong

    2008-12-01

    In the literature on automated negotiation, very few negotiation agents are designed with the flexibility to slightly relax their negotiation criteria to reach a consensus more rapidly and with more certainty. Furthermore, these relaxed-criteria negotiation agents were not equipped with the ability to enhance their performance by learning and evolving their relaxed-criteria negotiation rules. The impetus of this work is designing market-driven negotiation agents (MDAs) that not only have the flexibility of relaxing bargaining criteria using fuzzy rules, but can also evolve their structures by learning new relaxed-criteria fuzzy rules to improve their negotiation outcomes as they participate in negotiations in more e-markets. To this end, an evolutionary algorithm for adapting and evolving relaxed-criteria fuzzy rules was developed. Implementing the idea in a testbed, two kinds of experiments for evaluating and comparing EvEMDAs (MDAs with relaxed-criteria rules that are evolved using the evolutionary algorithm) and EMDAs (MDAs with relaxed-criteria rules that are manually constructed) were carried out through stochastic simulations. Empirical results show that: 1) EvEMDAs generally outperformed EMDAs in different types of e-markets and 2) the negotiation outcomes of EvEMDAs generally improved as they negotiated in more e-markets.

  8. On the Benefits of Divergent Search for Evolved Representations

    DEFF Research Database (Denmark)

    Lehman, Joel; Risi, Sebastian; Stanley, Kenneth O

    2012-01-01

    explicit objectives that are consequently divergent may implicitly reward lineages that continually diverge, thereby indirectly selecting for evolvable representations that are better able to diverge further. This paper reviews a range of past results that support such a hypothesis from a method called...

  9. Fast, comfortable or economical: Evolving platooning strategies with many objectives

    NARCIS (Netherlands)

    Willigen, W. van; Haasdijk, E.; Kester, L.J.H.M.

    2013-01-01

    The research in this paper is inspired by a vision of intelligent vehicles that autonomously move along motorways: they join and leave trains of vehicles (platoons), overtake other vehicles, etc. We propose a multi-objective evolutionary algorithm that evolves high-level controllers for such

  10. Evolving Robot Controllers for Structured Environments Through Environment Decomposition

    DEFF Research Database (Denmark)

    Moreno, Rodrigo; Faiña, Andres; Støy, Kasper

    2015-01-01

    into four different sub-environments and evolve controllers that generalize to traverse two larger environments composed of the sub-environments. We also study two strategies for presenting the sub-environments to the evolutionary algorithm: all sub-environments at the same time and in sequence. Results...

  11. The urban watershed continuum: evolving spatial and temporal dimensions

    Science.gov (United States)

    Sujay S. Kaushal; Kenneth T. Belt

    2012-01-01

    Urban ecosystems are constantly evolving, and they are expected to change in both space and time with active management or degradation. An urban watershed continuum framework recognizes a continuum of engineered and natural hydrologic flowpaths that expands hydrologic networks in ways that are seldom considered. It recognizes that the nature of hydrologic connectivity...

  12. Optimization as side-effect of evolving allelopathic diversity

    NARCIS (Netherlands)

    Pagie, L.; Hogeweg, P.

    2001-01-01

    Many bacteria carry gene complexes that code for a toxin-antidote pair, e.g. colicin systems. Such gene complexes can be advantageous for its host by killing competitor bacteria while the antidote protects the host. However, in order to evolve a novel and useful toxin first a proper antidote must

  13. Did language evolve like the vertebrate eye? | Botha | Stellenbosch ...

    African Journals Online (AJOL)

    Did language evolve like the vertebrate eye? R P Botha. Abstract. No abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.5774/34-0-33 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  14. A Review of Microbiology: An Evolving Science, Second Edition

    Directory of Open Access Journals (Sweden)

    Barbara May

    2011-09-01

    Full Text Available Review of: Microbiology: An Evolving Science, 2nd ed.; Joan L Slonczweski and John W. Foster; (2011. W.W. Norton & Company, New York NY. 1096 pages. ISBN: 978-0-393-93447-2. Normal 0 false false false EN-US X-NONE X-NONE

  15. The Evolving Military Learner Population: A Review of the Literature

    Science.gov (United States)

    Ford, Kate; Vignare, Karen

    2015-01-01

    This literature review examines the evolving online military learner population with emphasis on current generation military learners, who are most frequently Post-9/11 veterans. The review synthesizes recent scholarly and grey literature on military learner demographics and attributes, college experiences, and academic outcomes against a backdrop…

  16. Developing Collective Learning Extension for Rapidly Evolving Information System Courses

    Science.gov (United States)

    Agarwal, Nitin; Ahmed, Faysal

    2017-01-01

    Due to rapidly evolving Information System (IS) technologies, instructors find themselves stuck in the constant game of catching up. On the same hand students find their skills obsolete almost as soon as they graduate. As part of IS curriculum and education, we need to emphasize more on teaching the students "how to learn" while keeping…

  17. Evolving Nature of Sexual Orientation and Gender Identity

    Science.gov (United States)

    Jourian, T. J.

    2015-01-01

    This chapter discusses the historical and evolving terminology, constructs, and ideologies that inform the language used by those who are lesbian, gay, bisexual, and same-gender loving, who may identify as queer, as well as those who are members of trans* communities from multiple and intersectional perspectives.

  18. Optimists' Creed: Brave New Cyberlearning, Evolving Utopias (Circa 2041)

    Science.gov (United States)

    Burleson, Winslow; Lewis, Armanda

    2016-01-01

    This essay imagines the role that artificial intelligence innovations play in the integrated living, learning and research environments of 2041. Here, in 2041, in the context of increasingly complex wicked challenges, whose solutions by their very nature continue to evade even the most capable experts, society and technology have co-evolved to…

  19. A Conceptual Framework for Evolving, Recommender Online Learning Systems

    Science.gov (United States)

    Peiris, K. Dharini Amitha; Gallupe, R. Brent

    2012-01-01

    A comprehensive conceptual framework is developed and described for evolving recommender-driven online learning systems (ROLS). This framework describes how such systems can support students, course authors, course instructors, systems administrators, and policy makers in developing and using these ROLS. The design science information systems…

  20. Disaggregating soil erosion processes within an evolving experimental landscape

    Science.gov (United States)

    Soil-mantled landscapes subjected to rainfall, runoff events, and downstream base level adjustments will erode and evolve in time and space. Yet the precise mechanisms for soil erosion also will vary, and such variations may not be adequately captured by soil erosion prediction technology. This st...

  1. Thermogravimetry-evolved gas analysis–mass spectrometry system ...

    Indian Academy of Sciences (India)

    This system which gives complete information on weight change, heat change, nature and content of evolved gases is being used for. temperature programmed decomposition (TPD),; synthesis of nanocrystalline materials,; gas–solid interactions and; analysis of gas mixtures. The TPD of various inorganic oxyanion solids ...

  2. Generic, Property Based Queries for Evolvable Weaving Specifications

    NARCIS (Netherlands)

    Nagy, I.; Bergmans, Lodewijk; Gülesir, G.; Durr, P.E.A.; Aksit, Mehmet

    2005-01-01

    In the current aspect-oriented languages, advices and pointcuts are explicitly associated in general. This results in weaving specifications that are less evolvable and need more maintenance during the development of a system. To address this issue, we propose associative access to advices and

  3. The Evolving Status of Photojournalism Education. ERIC Digest.

    Science.gov (United States)

    Cookman, Claude

    Noting that new technologies are resulting in extensive changes in the field of photojournalism, both as it is practiced and taught, this Digest reviews this rapidly evolving field of education and professional practice. It discusses what digital photography is; the history of digital photography; how digital photography has changed…

  4. Sextant: Visualizing time-evolving linked geospatial data

    NARCIS (Netherlands)

    C. Nikolaou (Charalampos); K. Dogani (Kallirroi); K. Bereta (Konstantina); G. Garbis (George); M. Karpathiotakis (Manos); K. Kyzirakos (Konstantinos); M. Koubarakis (Manolis)

    2015-01-01

    textabstractThe linked open data cloud is constantly evolving as datasets get continuously updated with newer versions. As a result, representing, querying, and visualizing the temporal dimension of linked data is crucial. This is especially important for geospatial datasets that form the backbone

  5. SexTant: Visualizing Time-Evolving Linked Geospatial Data

    NARCIS (Netherlands)

    K. Bereta (Konstantina); C. Nikolaou (Charalampos); M. Karpathiotakis (Manos); K. Kyzirakos (Konstantinos); M. Koubarakis (Manolis); E. Blomqvist; T. Groza

    2013-01-01

    htmlabstractWe present SexTant, a Web-based system for the visualization and exploration of time-evolving linked geospatial data and the creation, sharing, and collaborative editing of "temporally-enriched" thematic maps which are produced by combining dierent sources of such data.

  6. Water Footprint Assessment : Evolvement of a New Research Field

    NARCIS (Netherlands)

    Hoekstra, Arjen Y.

    2017-01-01

    This paper reviews the evolvement of water footprint assessment (WFA) as a new research field over the past fifteen years. The research is rooted in four basic thoughts: (1) there is a global dimension to water management because water-intensive commodities are internationally traded, so we must

  7. Evolving information systems: meeting the ever-changing environment

    NARCIS (Netherlands)

    Oei, J.L.H.; Proper, H.A.; Falkenberg, E.D.

    1994-01-01

    To meet the demands of organizations and their ever-changing environment, information systems are required which are able to evolve to the same extent as organizations do. Such a system has to support changes in all time-and application-dependent aspects. In this paper, requirements and a conceptual

  8. Heritage – A Conceptually Evolving and Dissonant Phenomenon ...

    African Journals Online (AJOL)

    I therefore, drawing from literature and experiences gained during field observations and focus group interviews, came up with the idea of working with three viewpoints of heritage. Drawing on real life cases I argue that current heritage management and education practices' failure to recognise and respect the evolving, ...

  9. Evolving strategies for cancer and autoimmunity: back to the future

    Directory of Open Access Journals (Sweden)

    Peter John Lane

    2014-04-01

    Full Text Available Although current thinking has focused on genetic variation between individuals and environmental influences as underpinning susceptibility to both autoimmunity and cancer, an alternative view is that human susceptibility to these diseases is a consequence of the way the immune system evolved. It is important to remember that the immunological genes that we inherit and the systems that they control were shaped by the drive for reproductive success rather than for individual survival. It is our view that human susceptibility to autoimmunity and cancer are the evolutionarily acceptable side effects of the immune adaptations that evolved in early placental mammals to accommodate a fundamental change in reproductive strategy. Studies of immune function in mammals shows that high affinity antibodies and CD4 memory, along with its regulation, co-evolved with placentation. By dissection of the immunologically active genes and proteins that evolved to regulate this step change in the mammalian immune system, clues have emerged that may reveal ways of detuning both effector and regulatory arms of the immune system to abrogate autoimmune responses whilst preserving protection against infection. Paradoxically, it appears that such a detuned and deregulated immune system is much better equipped to mount anti-tumor immune responses against cancers.

  10. Baby dumping and evolving baby factories in Nigeria: their ...

    African Journals Online (AJOL)

    Baby dumping and evolving baby factories in Nigeria: their implication for child right and social protection. ... Journal of Religion and Human Relations ... a society-based approach which involves a thorough overhaul of our rigid social orientation which will create room for a conducive environment for child rights and social ...

  11. Evolving Concepts of Development through the Experience of ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... facing developing countries; how thinking has evolved on particular aspects of development; and how different organizations espouse and use ideas to influence development. The edited volume will be submitted to an academic press for publication, along with a companion volume appropriate for university teaching.

  12. Cyperus difformis evolves resistance to propanil

    DEFF Research Database (Denmark)

    Valverde Mena, Bernal Eduardo; Boddy, Louis G.; Pedroso, Rafael M.

    2014-01-01

    Cyperus difformis L. is one of the worst weeds of rice world-wide and has evolved resistance to acetolactate synthase (ALS)-inhibiting herbicides in rice fields of California. Propanil use was intensified to control the widespread resistant biotypes. Rice growers have recently experienced poor co...

  13. Evolutionary genetics: you are what you evolve to eat.

    Science.gov (United States)

    Dworkin, Ian; Jones, Corbin D

    2015-04-20

    The evolution of host specialization can potentially limit future evolutionary opportunities. A new study now shows how Drosophila sechellia, specialized on the toxic Morinda fruit, has evolved new nutritional needs influencing its reproduction. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Changes of scaling relationships in an evolving population: The example of "sedimentary" stylolites

    Science.gov (United States)

    Peacock, D. C. P.; Korneva, I.; Nixon, C. W.; Rotevatn, A.

    2017-03-01

    Bed-parallel (;sedimentary;) stylolites are used as an example of a population that evolves by the addition of new components, their growth and their merger. It is shown that this style of growth controls the changes in the scaling relationships of the population. Stylolites tend to evolve in carbonate rocks through time, for example by compaction during progressive burial. The evolution of a population of stylolites, and their likely effects on porosity, are demonstrated using simple numerical models. Starting with a power-law distribution, the adding of new stylolites, the increase in their amplitudes and their merger decrease the slope of magnitude versus cumulative frequency of the population. The population changes to a non-power-law distribution as smaller stylolites merge to form larger stylolites. The results suggest that other populations can be forward- or backward-modelled, such as fault lengths, which also evolve by the addition of components, their growth and merger. Consideration of the ways in which populations change improves understanding of scaling relationships and vice versa, and would assist in the management of geofluid reservoirs.

  15. Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies

    Directory of Open Access Journals (Sweden)

    Eric Sterner

    2017-08-01

    Full Text Available Antibodies play a crucial role in host defense and are indispensable research tools, diagnostics, and therapeutics. Antibody generation involves binding of genomically encoded germline antibodies followed by somatic hypermutation and in vivo selection to obtain antibodies with high affinity and selectivity. Understanding this process is critical for developing monoclonal antibodies, designing effective vaccines, and understanding autoantibody formation. Prior studies have found that antibodies to haptens, peptides, and proteins evolve from polyspecific germline antibodies. The immunological evolution of antibodies to mammalian glycans has not been studied. Using glycan microarrays, protein microarrays, cell binding studies, and molecular modeling, we demonstrate that therapeutic antibodies to the tumor-associated ganglioside GD2 evolved from highly specific germline precursors. The results have important implications for developing vaccines and monoclonal antibodies that target carbohydrate antigens. In addition, they demonstrate an alternative pathway for antibody evolution within the immune system that is distinct from the polyspecific germline pathway.

  16. Strategy for Extensible, Evolving Terminology for the Materials Genome Initiative Efforts

    Science.gov (United States)

    Bhat, Talapady N.; Bartolo, Laura M.; Kattner, Ursula R.; Campbell, Carelyn E.; Elliott, John T.

    2015-08-01

    Intuitive, flexible, and evolving terminology plays a significant role in capitalizing on recommended knowledge representation models for materials engineering applications. In this article, we present a proposed rules-based approach with initial examples from a growing corpus of materials terms in the National Institute of Standards and Technology (NIST) Materials Data Repository. Our method aims to establish a common, consistent, and evolving set of rules for creating or extending terminology as needed to describe materials data. The rules are intended to be simple and generalizable for users to understand and extend as well as for groups to apply to their own repositories. The rules generate terms that facilitate machine processing and decision making.

  17. Sexually selected traits evolve positive allometry when some matings occur irrespective of the trait.

    Science.gov (United States)

    Fromhage, Lutz; Kokko, Hanna

    2014-05-01

    Positive allometry of secondary sexual traits (whereby larger individuals have disproportionally larger traits than smaller individuals) has been called one of the most pervasive and poorly understood regularities in the study of animal form and function. Its widespread occurrence is in contrast with theoretical predictions that it should evolve only under rather special circumstances. Using a combination of mathematical modeling and simulations, here we show that positive allometry is predicted to evolve under much broader conditions than previously recognized. This result hinges on the assumption that mating success is not necessarily zero for males with the lowest trait values: for example, a male who lacks horns or antlers might still be able to copulate if encountering an unguarded female. We predict the strongest positive allometry when males typically (but not always) compete in large groups, and when trait differences decisively determine the outcome of competitive interactions. © 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.

  18. Evolving public health nursing roles: focus on community participatory health promotion and prevention.

    Science.gov (United States)

    Kulbok, Pamela A; Thatcher, Esther; Park, Eunhee; Meszaros, Peggy

    2012-05-31

    Public health nursing (PHN) practice is population-focused and requires unique knowledge, competencies, and skills. Early public health nursing roles extended beyond sick care to encompass advocacy, community organizing, health education, and political and social reform. Likewise, contemporary public health nurses practice in collaboration with agencies and community members. The purpose of this article is to examine evolving PHN roles that address complex, multi-causal, community problems. A brief background and history of this role introduces an explanation of the community participation health promotion model. A community-based participatory research project, Youth Substance Use Prevention in a Rural County provides an exemplar for description of evolving PHN roles focused on community health promotion and prevention. Also included is discussion about specific competencies for PHNs in community participatory health promoting roles and the contemporary PHN role.

  19. A rapidly evolving secretome builds and patterns a sea shell

    Directory of Open Access Journals (Sweden)

    Green Kathryn

    2006-11-01

    Full Text Available Abstract Background Instructions to fabricate mineralized structures with distinct nanoscale architectures, such as seashells and coral and vertebrate skeletons, are encoded in the genomes of a wide variety of animals. In mollusks, the mantle is responsible for the extracellular production of the shell, directing the ordered biomineralization of CaCO3 and the deposition of architectural and color patterns. The evolutionary origins of the ability to synthesize calcified structures across various metazoan taxa remain obscure, with only a small number of protein families identified from molluskan shells. The recent sequencing of a wide range of metazoan genomes coupled with the analysis of gene expression in non-model animals has allowed us to investigate the evolution and process of biomineralization in gastropod mollusks. Results Here we show that over 25% of the genes expressed in the mantle of the vetigastropod Haliotis asinina encode secreted proteins, indicating that hundreds of proteins are likely to be contributing to shell fabrication and patterning. Almost 85% of the secretome encodes novel proteins; remarkably, only 19% of these have identifiable homologues in the full genome of the patellogastropod Lottia scutum. The spatial expression profiles of mantle genes that belong to the secretome is restricted to discrete mantle zones, with each zone responsible for the fabrication of one of the structural layers of the shell. Patterned expression of a subset of genes along the length of the mantle is indicative of roles in shell ornamentation. For example, Has-sometsuke maps precisely to pigmentation patterns in the shell, providing the first case of a gene product to be involved in molluskan shell pigmentation. We also describe the expression of two novel genes involved in nacre (mother of pearl deposition. Conclusion The unexpected complexity and evolvability of this secretome and the modular design of the molluskan mantle enables

  20. Phenotypic effect of mutations in evolving populations of RNA molecules

    Directory of Open Access Journals (Sweden)

    Manrubia Susanna C

    2010-02-01

    Full Text Available Abstract Background The secondary structure of folded RNA sequences is a good model to map phenotype onto genotype, as represented by the RNA sequence. Computational studies of the evolution of ensembles of RNA molecules towards target secondary structures yield valuable clues to the mechanisms behind adaptation of complex populations. The relationship between the space of sequences and structures, the organization of RNA ensembles at mutation-selection equilibrium, the time of adaptation as a function of the population parameters, the presence of collective effects in quasispecies, or the optimal mutation rates to promote adaptation all are issues that can be explored within this framework. Results We investigate the effect of microscopic mutations on the phenotype of RNA molecules during their in silico evolution and adaptation. We calculate the distribution of the effects of mutations on fitness, the relative fractions of beneficial and deleterious mutations and the corresponding selection coefficients for populations evolving under different mutation rates. Three different situations are explored: the mutation-selection equilibrium (optimized population in three different fitness landscapes, the dynamics during adaptation towards a goal structure (adapting population, and the behavior under periodic population bottlenecks (perturbed population. Conclusions The ratio between the number of beneficial and deleterious mutations experienced by a population of RNA sequences increases with the value of the mutation rate μ at which evolution proceeds. In contrast, the selective value of mutations remains almost constant, independent of μ, indicating that adaptation occurs through an increase in the amount of beneficial mutations, with little variations in the average effect they have on fitness. Statistical analyses of the distribution of fitness effects reveal that small effects, either beneficial or deleterious, are well described by a Pareto

  1. Climate in Context - How partnerships evolve in regions

    Science.gov (United States)

    Parris, A. S.

    2014-12-01

    In 2015, NOAA's RISA program will celebrate its 20th year of exploration in the development of usable climate information. In the mid-1990s, a vision emerged to develop interdisciplinary research efforts at the regional scale for several important reasons. Recognizable climate patterns, such as the El Nino Southern Oscillation (ENSO), emerge at the regional level where our understanding of observations and models coalesce. Critical resources for society are managed in a context of regional systems, such as water supply and human populations. Multiple scales of governance (local, state, and federal) with complex institutional relationships can be examined across a region. Climate information (i.e. data, science, research etc) developed within these contexts has greater potential for use. All of this work rests on a foundation of iterative engagement between scientists and decision makers. Throughout these interactions, RISAs have navigated diverse politics, extreme events and disasters, socio-economic and ecological disruptions, and advances in both science and technology. Our understanding of information needs is evolving into a richer understanding of complex institutional, legal, political, and cultural contexts within which people can use science to make informed decisions. The outcome of RISA work includes both cases where climate information was used in decisions and cases where capacity for using climate information and making climate resilient decisions has increased over time. In addition to balancing supply and demand of scientific information, RISAs are engaged in a social process of reconciling climate information use with important drivers of society. Because partnerships are critical for sustained engagement, and because engagement is critically important to the use of science, the rapid development of new capacity in regionally-based science programs focused on providing climate decision support is both needed and challenging. New actors can bolster

  2. Páramo is the world’s fastest evolving and coolest biodiversity hotspot

    Directory of Open Access Journals (Sweden)

    Santiago eMadriñán

    2013-10-01

    Full Text Available Understanding the processes that cause speciation is a key aim of evolutionary biology. Lineages or biomes that exhibit recent and rapid diversification are ideal model systems for determining these processes. Species rich biomes reported to be of relatively recent origin, i.e., since the beginning of the Miocene, include Mediterranean ecosystems such as the California Floristic Province, oceanic islands such as the Hawaiian archipelago and the Neotropical high elevation ecosystem of the Páramos. Páramos constitute grasslands above the forest tree-line (at elevations of c. 2800–4700 m with high species endemism. Organisms that occupy this ecosystem are a likely product of unique adaptations to an extreme environment that evolved during the last three to five million years when the Andes reached an altitude that was capable of sustaining this type of vegetation. We compared net diversification rates of lineages in fast evolving biomes using 73 dated molecular phylogenies. Based on our sample, we demonstrate that average net diversification rates of Páramo plant lineages are faster than those of other reportedly fast evolving hotspots and that the faster evolving lineages are more likely to be found in Páramos than the other hotspots. Páramos therefore represent the ideal model system for studying diversification processes. Most of the speciation events that we observed in the Páramos (144 out of 177 occurred during the Pleistocene possibly due to the effects of species range contraction and expansion that may have resulted from the well-documented climatic changes during that period. Understanding these effects will assist with efforts to determine how future climatic changes will impact plant populations.

  3. Relationship among phenotypic plasticity, phenotypic fluctuations, robustness, and evolvability; Waddington's legacy revisited under the spirit of Einstein.

    Science.gov (United States)

    Kaneko, Kunihiko

    2009-10-01

    Questions on possible relationship between phenotypic plasticity and evolvability, and that between robustness and evolution have been addressed over decades in the field of evolution-development. Based on laboratory evolution experiments and numerical simulations of gene expression dynamics model with an evolving transcription network, we propose quantitative relationships on plasticity, phenotypic fluctuations, and evolvability. By introducing an evolutionary stability assumption on the distribution of phenotype and genotype, the proportionality among phenotypic plasticity against environmental change, variances of phenotype fluctuations of genetic and developmental origins, and evolution speed is obtained. The correlation between developmental robustness to noise and evolutionary robustness to mutation is analysed by simulations of the gene network model. These results provide quantitative formulation on canalization and genetic assimilation, in terms of fluctuations of gene expression levels.

  4. The Dynamical Classification of Centaurs which Evolve into Comets

    Science.gov (United States)

    Wood, Jeremy R.; Horner, Jonathan; Hinse, Tobias; Marsden, Stephen; Swinburne University of Technology

    2016-10-01

    Centaurs are small Solar system bodies with semi-major axes between Jupiter and Neptune and perihelia beyond Jupiter. Centaurs can be further subclassified into two dynamical categories - random walk and resonance hopping. Random walk Centaurs have mean square semi-major axes () which vary in time according to a generalized diffusion equation where ~t2H. H is the Hurst exponent with 0 for resonance hopping Centaurs is not well described by generalized diffusion.The aim of this study is to determine which dynamical type of Centaur is most likely to evolve into each class of comet. 31,722 fictional massless test particles were integrated for 3 Myr in the 6-body problem (Sun, Jovian planets, test particle). Initially each test particle was a member of one of four groups. The semi-major axes of all test particles in a group were clustered within 0.27 au from a first order, interior Mean Motion resonance of Neptune. The resonances were centered at 18.94 au, 22.95 au, 24.82 au and 28.37 au.If the perihelion of a test particle reached particle was considered to be a comet and classified as either a random walk or resonance hopping Centaur. The results showed that over 4,000 test particles evolved into comets within 3 Myr. 59% of these test particles were random walk and 41% were resonance hopping. The behavior of the semi-major axis in time was usually well described by generalized diffusion for random walk Centaurs (ravg = 0.98) and poorly described for resonance hopping Centaurs (ravg = 0.52). The average Hurst exponent was 0.48 for random walk Centaurs and 0.20 for resonance hopping Centaurs. Random walk Centaurs were more likely to evolve into short period comets while resonance hopping Centaurs were more likely to evolve into long period comets. For each initial cluster, resonance hopping Centaurs took longer to evolve into comets than random walk Centaurs. Overall the population of random walk Centaurs averaged 143 kyr to evolve into comets, and the population of

  5. The Evolving Role of Emergency Departments in the United States.

    Science.gov (United States)

    Morganti, Kristy Gonzalez; Bauhoff, Sebastian; Blanchard, Janice C; Abir, Mahshid; Iyer, Neema; Smith, Alexandria; Vesely, Joseph V; Okeke, Edward N; Kellermann, Arthur L

    2013-01-01

    The research described in this article was performed to develop a more complete picture of how hospital emergency departments (EDs) contribute to the U.S. health care system, which is currently evolving in response to economic, clinical, and political pressures. Using a mix of quantitative and qualitative methods, it explores the evolving role that EDs and the personnel who staff them play in evaluating and managing complex and high-acuity patients, serving as the key decisionmaker for roughly half of all inpatient hospital admissions, and serving as "the safety net of the safety net" for patients who cannot get care elsewhere. The report also examines the role that EDs may soon play in either contributing to or helping to control the rising costs of health care.

  6. Real-time evolvable pulse shaper for radiation measurements

    Energy Technology Data Exchange (ETDEWEB)

    Lanchares, Juan, E-mail: julandan@dacya.ucm.es [Facultad de Informática, Universidad Complutense de Madrid (UCM), C/Prof. José García Santesmases s/n, 28040 Madrid (Spain); Garnica, Oscar, E-mail: ogarnica@dacya.ucm.es [Facultad de Informática, Universidad Complutense de Madrid (UCM), C/Prof. José García Santesmases s/n, 28040 Madrid (Spain); Risco-Martín, José L., E-mail: jlrisco@dacya.ucm.es [Facultad de Informática, Universidad Complutense de Madrid (UCM), C/Prof. José García Santesmases s/n, 28040 Madrid (Spain); Ignacio Hidalgo, J., E-mail: hidalgo@dacya.ucm.es [Facultad de Informática, Universidad Complutense de Madrid (UCM), C/Prof. José García Santesmases s/n, 28040 Madrid (Spain); Regadío, Alberto, E-mail: alberto.regadio@insa.es [Área de Tecnologías Electrónicas, Instituto Nacional de Técnica Aeroespacial (INTA), 28850 Torrejón de Ardoz, Madrid (Spain)

    2013-11-01

    In the last two decades, recursive algorithms for real-time digital pulse shaping in pulse height measurements have been developed and published in number of articles and textbooks. All these algorithms try to synthesize in real time optimum or near optimum shapes in the presence of noise. Even though some of these shapers can be considered effective designs, some side effects like aging cannot be ignored. We may observe that after sensors degradation, the signal obtained is not valid. In this regard, we present in this paper a novel technique that, based on evolvable hardware concepts, is able to evolve the degenerated shaper into a new design with better performance than the original one under the new sensor features.

  7. The Use of Genetic Programming to Evolve Passive Filter Circuits

    OpenAIRE

    Ogri J. Ushie; Abbod, Maysam F.; Julie C. Ogbulezie

    2017-01-01

    This paper introduces the use of Genetic Programming (GP), Genetic Folding and symbolic circuit analysis in Matlab for the evolution of passive filter circuits. Instead of combining MATLAB and PSPICE in electronic circuit simulation, in this work, only MATLAB is used. It helps to reduce elapsed time for transferring the simulation between the two software packages. The circuit evolved from GP using the Matlab program and is automatically converted into a symbolic netlist also by using a Matla...

  8. Evolving Pacing Strategies for Team Pursuit Track Cycling

    OpenAIRE

    Wagner, Markus; Day, Jareth; Jordan, Diora; Kroeger, Trent; Neumann, Frank

    2011-01-01

    Team pursuit track cycling is a bicycle racing sport held on velodromes and is part of the Summer Olympics. It involves the use of strategies to minimize the overall time that a team of cyclists needs to complete a race. We present an optimisation framework for team pursuit track cycling and show how to evolve strategies using metaheuristics for this interesting real-world problem. Our experimental results show that these heuristics lead to significantly better strategies than state-of-art st...

  9. ONMCGP: Orthogonal Neighbourhood Mutation Cartesian Genetic Programming for Evolvable Hardware

    Science.gov (United States)

    I, Fuchuan N.; I, Yuanxiang L.; E, Peng K.

    2014-03-01

    Evolvable Hardware is facing the problems of scalability and stalling effect. This paper proposed a novel Orthogonal Neighbourhood Mutation (ONM) operator in Cartesian genetic programming (CGP), to reduce the stalling effect in CGP and improve the efficiency of the algorithms.The method incorporates with Differential Evolution strategy. Demonstrated by experiments on benchmark, the proposed Orthogonal Neighbourhood Search can jump out of Local optima, reduce the stalling effect in CGP and the algorithm convergence faster.

  10. A Rapidly Evolving Active Region NOAA 8032 observed on April ...

    Indian Academy of Sciences (India)

    1997-04-15

    The active region NOAA 8032 of April 15, 1997 was observed to evolve rapidly. The GOES X-ray data showed a number of sub-flares and two C-class flares during the 8-9 hours of its evolution. The magnetic evolution of this region is studied to ascertain its role in flare production. Large changes were observed in magnetic ...

  11. india's northward drift and collision with asia: evolving faunal response

    Indian Academy of Sciences (India)

    INDIA'S NORTHWARD DRIFT AND COLLISION WITH ASIA: EVOLVING FAUNAL RESPONSE · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Slide 20 · Slide 21 · Slide 22 · Slide 23 · Slide 24.

  12. New nuclear build and evolving radiation protection challenges.

    Science.gov (United States)

    Lazo, Edward

    2011-01-01

    Radiological protection has continued to evolve in order to meet emerging challenges and will continue to do so. This paper will discuss the scientific and social challenges that will or may be faced by the radiological protection community in the coming 10 to 20 y and how these may affect what is expected to be a renewed interest in building and operating nuclear power plants for electricity generation. Copyright © 2010 Health Physics Society

  13. TRICARE Policy and Operations: Evolving to Support the Quadruple Aim

    Science.gov (United States)

    2011-01-24

    Examples of Evolution – TRICARE in Alaska – Autism Services Demonstration 2011 MHS Conference 3 Track L  Evolving to achieve the Quadruple Aim...Heidelberg MEDDAC Lessons Learned 1, 2, 3, 4 1, 2, 3, 4 2 a. TRICARE in Alaska b. Autism Services Demonstration c. A Regional View 3 1 1, 2...3, 4 3 TRICARE Pharmacy Programs 3, 4 4 TRICARE for Reserves and National Guard 1, 2, 3 5 TRICARE Dental Programs 1, 2, 4 6 a

  14. Hemicrania continua evolving from cluster headache responsive to valproic acid.

    Science.gov (United States)

    Lambru, Giorgio; Castellini, Paola; Bini, Annamaria; Evangelista, Andrea; Manzoni, Gian Camillo; Torelli, Paola

    2008-10-01

    Hemicrania continua (HC) is a rare type of primary headache characterized by a prompt and enduring response to indomethacin. We describe a patient who suffered from cluster headache evolving into ipsilateral HC, who does not tolerate a long-term indomethacin therapy. The case was complex in terms of diagnosis, associated comorbidity, and choice of treatment; after several trials with different therapeutic regimens, we started the patient on a therapy with valproic acid and obtained an improvement of her HC.

  15. Breast cancer diagnosis based on evolvable fuzzy classifiers and feature selection

    Science.gov (United States)

    Lekkas, S.; Mikhailov, L.

    This paper presents an architecture for evolvable fuzzy rule-based classifiers, applied to the diagnosis of breast cancer, the second most frequent cause of cancer deaths in the female population. It is based on the eClass family of relative models, having the ability to evolve its fuzzy rule-base incrementally. This incremental adaptation is gradually developed by the influence that data bring, arriving from a data stream sequentially. Recent studies have shown that the eClass algorithms are very promising solution for decision making problems. Such on-line learning method has been extensively used for control applications and is also suitable for real time classification tasks, such as fault detection, diagnosis, robotic navigation etc. We propose the use of evolvable multiple-input-multipleoutput (MIMO) Takagi Sugeno Kang (TSK) rule-based classifiers of first order, to the diagnosis of breast cancer. Moreover we introduce a novel feature scoring function that identifies most valuable features of the data in real time. Our experiments show that the algorithm returns high classification rate and the results are comparable with other approaches that regard learning from numerical observations of medical nature.

  16. Biomimetic molecular design tools that learn, evolve, and adapt.

    Science.gov (United States)

    Winkler, David A

    2017-01-01

    A dominant hallmark of living systems is their ability to adapt to changes in the environment by learning and evolving. Nature does this so superbly that intensive research efforts are now attempting to mimic biological processes. Initially this biomimicry involved developing synthetic methods to generate complex bioactive natural products. Recent work is attempting to understand how molecular machines operate so their principles can be copied, and learning how to employ biomimetic evolution and learning methods to solve complex problems in science, medicine and engineering. Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials. These methods are being applied to organic chemistry to systematize reactions, create synthesis robots to carry out unit operations, and to devise closed loop flow self-optimizing chemical synthesis systems. Most scientific innovations and technologies pass through the well-known "S curve", with slow beginning, an almost exponential growth in capability, and a stable applications period. Adaptive, evolving, machine learning-based molecular design and optimization methods are approaching the period of very rapid growth and their impact is already being described as potentially disruptive. This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine.

  17. Biomimetic molecular design tools that learn, evolve, and adapt

    Directory of Open Access Journals (Sweden)

    David A Winkler

    2017-06-01

    Full Text Available A dominant hallmark of living systems is their ability to adapt to changes in the environment by learning and evolving. Nature does this so superbly that intensive research efforts are now attempting to mimic biological processes. Initially this biomimicry involved developing synthetic methods to generate complex bioactive natural products. Recent work is attempting to understand how molecular machines operate so their principles can be copied, and learning how to employ biomimetic evolution and learning methods to solve complex problems in science, medicine and engineering. Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials. These methods are being applied to organic chemistry to systematize reactions, create synthesis robots to carry out unit operations, and to devise closed loop flow self-optimizing chemical synthesis systems. Most scientific innovations and technologies pass through the well-known “S curve”, with slow beginning, an almost exponential growth in capability, and a stable applications period. Adaptive, evolving, machine learning-based molecular design and optimization methods are approaching the period of very rapid growth and their impact is already being described as potentially disruptive. This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine.

  18. Evolving Human Alteration of the Carbon Cycle: the Watershed Continuum

    Science.gov (United States)

    Kaushal, S.; Delaney Newcomb, K.; Newcomer Johnson, T.; Pennino, M. J.; Smith, R. M.; Beaulieu, J. J.; Belt, K.; Grese, M.; Blomquist, J.; Duan, S.; Findlay, S.; Likens, G.; Mayer, P. M.; Murthy, S.; Utz, R.; Yepsen, M.

    2014-12-01

    Watersheds experiencing land development are constantly evolving, and their biogeochemical signatures are expected to evolve across both space and time in drainage waters. We investigate how land development influences spatial and temporal evolution of the carbon cycle from small streams to major rivers in the Eastern U.S. Along the watershed continuum, we show that there is spatial evolution in: (1) the amount, chemical form, and bioavailability of carbon; (2) carbon retention/release at the reach scale; and (3) ecosystem metabolism of carbon from headwaters to coastal waters. Over shorter time scales, the interaction between land use and climate variability alters magnitude and frequency of carbon "pulses" in watersheds. Amounts and forms of carbon pulses in agricultural and urban watersheds respond similarly to climate variability due to headwater alteration and loss of ecosystem services to buffer runoff and temperature changes. Over longer time scales, land use change has altered organic carbon concentrations in tidal waters of Chesapeake Bay, and there have been increased bicarbonate alkalinity concentrations in rivers throughout the Eastern U.S. due to human activities. In summary, our analyses indicates that the form and reactivity of carbon have evolved over space and time along the watershed continuum with major implications for downstream ecosystem metabolism, biological oxygen demand, carbon dioxide production, and river alkalinization.

  19. Higher rates of sex evolve in spatially heterogeneous environments.

    Science.gov (United States)

    Becks, Lutz; Agrawal, Aneil F

    2010-11-04

    The evolution and maintenance of sexual reproduction has puzzled biologists for decades. Although this field is rich in hypotheses, experimental evidence is scarce. Some important experiments have demonstrated differences in evolutionary rates between sexual and asexual populations; other experiments have documented evolutionary changes in phenomena related to genetic mixing, such as recombination and selfing. However, direct experiments of the evolution of sex within populations are extremely rare (but see ref. 12). Here we use the rotifer, Brachionus calyciflorus, which is capable of both sexual and asexual reproduction, to test recent theory predicting that there is more opportunity for sex to evolve in spatially heterogeneous environments. Replicated experimental populations of rotifers were maintained in homogeneous environments, composed of either high- or low-quality food habitats, or in heterogeneous environments that consisted of a mix of the two habitats. For populations maintained in either type of homogeneous environment, the rate of sex evolves rapidly towards zero. In contrast, higher rates of sex evolve in populations experiencing spatially heterogeneous environments. The data indicate that the higher level of sex observed under heterogeneity is not due to sex being less costly or selection against sex being less efficient; rather sex is sufficiently advantageous in heterogeneous environments to overwhelm its inherent costs. Counter to some alternative theories for the evolution of sex, there is no evidence that genetic drift plays any part in the evolution of sex in these populations.

  20. Biomimetic molecular design tools that learn, evolve, and adapt

    Science.gov (United States)

    2017-01-01

    A dominant hallmark of living systems is their ability to adapt to changes in the environment by learning and evolving. Nature does this so superbly that intensive research efforts are now attempting to mimic biological processes. Initially this biomimicry involved developing synthetic methods to generate complex bioactive natural products. Recent work is attempting to understand how molecular machines operate so their principles can be copied, and learning how to employ biomimetic evolution and learning methods to solve complex problems in science, medicine and engineering. Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials. These methods are being applied to organic chemistry to systematize reactions, create synthesis robots to carry out unit operations, and to devise closed loop flow self-optimizing chemical synthesis systems. Most scientific innovations and technologies pass through the well-known “S curve”, with slow beginning, an almost exponential growth in capability, and a stable applications period. Adaptive, evolving, machine learning-based molecular design and optimization methods are approaching the period of very rapid growth and their impact is already being described as potentially disruptive. This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine. PMID:28694872

  1. Evolving Metadata in NASA Earth Science Data Systems

    Science.gov (United States)

    Mitchell, A.; Cechini, M. F.; Walter, J.

    2011-12-01

    NASA's effort to continually evolve its data systems led ECHO to enhancing the method in which it receives inventory metadata from the data centers to allow for multiple metadata formats including ISO 19115. ECHO's metadata model will also be mapped to the NASA-specific convention for ingesting science metadata into the ECHO system. As NASA's new Earth Science missions and data centers are migrating to the ISO 19115 standards, EOSDIS is developing metadata management resources to assist in the reading, writing and parsing ISO 19115 compliant metadata. To foster interoperability with other agencies and international partners, NASA is working to ensure that a common ISO 19115 convention is developed, enhancing data sharing capabilities and other data analysis initiatives. NASA is also investigating the use of ISO 19115 standards to encode data quality, lineage and provenance with stored values. A common metadata standard across NASA's Earth Science data systems promotes interoperability, enhances data utilization and removes levels of uncertainty found in data products.

  2. Recently evolved diversity and convergent radiations of rainforest mahoganies (Meliaceae) shed new light on the origins of rainforest hyperdiversity

    NARCIS (Netherlands)

    Koenen, E.J.M.; Clarkson, J.J.; Pennington, T.D.; Chatrou, L.W.

    2015-01-01

    •Tropical rainforest hyperdiversity is often suggested to have evolved over a long time-span (the ‘museum’ model), but there is also evidence for recent rainforest radiations. The mahoganies (Meliaceae) are a prominent plant group in lowland tropical rainforests world-wide but also occur in all

  3. Evolving Expert Knowledge Bases: Applications of Crowdsourcing and Serious Gaming to Advance Knowledge Development for Intelligent Tutoring Systems

    Science.gov (United States)

    Floryan, Mark

    2013-01-01

    This dissertation presents a novel effort to develop ITS technologies that adapt by observing student behavior. In particular, we define an evolving expert knowledge base (EEKB) that structures a domain's information as a set of nodes and the relationships that exist between those nodes. The structure of this model is not the particularly novel…

  4. The Effect of Evolving Damage on the Finite Strain Response of Inelastic and Viscoelastic Composites

    Directory of Open Access Journals (Sweden)

    Jacob Aboudi

    2009-11-01

    Full Text Available A finite strain micromechanical model is generalized in order to incorporate the effect of evolving damage in the metallic and polymeric phases of unidirectional compostes. As a result, it is possible to predict the response of composites with ductile and brittle phases undergoing large coupled inelastic-damage and viscoelastic-damage deformations, respectively. For inelastic composites, both finite strain elastoplastic (time-independent and viscoplastic (time-dependent behaviors are considered. The ductile phase exhibits initially a hyperelastic behavior which is followed by an inelastic one, and its analysis is based on the multiplicative split of its deformation gradient into elastic and inelastic parts. The embedded damage mechanisms and their evolutions are based on Gurson’s (which is suitable for the modeling of porous materials and Lemaitre’s finite strain models. Similarly, the polymeric phase exhibits large viscoelastic deformations in which the damage evolves according to a suitable evolution law that depends on the amount of accumulated deformation. Evolving damage in hyperelastic materials can be analyzed as a special case by neglecting the viscous effects. The micromechanical analysis is based on the homogenization technique for periodic multiphase materials, which establishes the strong form of the Lagrangian equilibrium equations. These equations are implemented together with the interfacial and periodic boundary conditions, in conjunction with the current tangent tensor of the phase. As a result, the instantaneous strain concentration tensor that relates the local deformation gradient of the phase to the externally applied deformation gradient is established. This provides also the instantaneous effective stiffness tangent tensor of the composite as well as its current response. Results are given that exhibit the effect of damage on the initial yield surfaces, response and possible failure of the composite.

  5. Risk-Based Prioritization of Research for Aviation Security Using Logic-Evolved Decision Analysis

    Science.gov (United States)

    Eisenhawer, S. W.; Bott, T. F.; Sorokach, M. R.; Jones, F. P.; Foggia, J. R.

    2004-01-01

    The National Aeronautics and Space Administration is developing advanced technologies to reduce terrorist risk for the air transportation system. Decision support tools are needed to help allocate assets to the most promising research. An approach to rank ordering technologies (using logic-evolved decision analysis), with risk reduction as the metric, is presented. The development of a spanning set of scenarios using a logic-gate tree is described. Baseline risk for these scenarios is evaluated with an approximate reasoning model. Illustrative risk and risk reduction results are presented.

  6. Why, when and where did honey bee dance communication evolve?

    Directory of Open Access Journals (Sweden)

    Robbie eI'Anson Price

    2015-11-01

    Full Text Available Honey bees (Apis sp. are the only known bee genus that uses nest-based communication to provide nest-mates with information about the location of resources, the so-called dance language. Successful foragers perform waggle dances for high quality food sources and suitable nest-sites during swarming. However, since many species of social insects do not communicate the location of resources to their nest-mates, the question of why the dance language evolved is of ongoing interest. We review recent theoretical and empirical research into the ecological circumstances that make dance communication beneficial in present day environments. This research suggests that the dance language is most beneficial when food sources differ greatly in quality and are hard to find. The dances of extant honey bee species differ in important ways, and phylogenetic studies suggest an increase in dance complexity over time: species with the least complex dance were the first to appear and species with the most complex dance are the most derived. We review the fossil record of honey bees and speculate about the time and context (foraging vs. swarming in which spatially referential dance communication might have evolved. We conclude that there are few certainties about when the dance language first appeared; dance communication could be older than 40 million years and, thus, predate the genus Apis, or it could be as recent as 20 million years when extant honey bee species diverged during the early Miocene. The most parsimonious scenario assumes it evolved in a sub-tropical to temperate climate, with patchy vegetation somewhere in Eurasia.

  7. Evolving networks-Using past structure to predict the future

    Science.gov (United States)

    Shang, Ke-ke; Yan, Wei-sheng; Small, Michael

    2016-08-01

    Many previous studies on link prediction have focused on using common neighbors to predict the existence of links between pairs of nodes. More broadly, research into the structural properties of evolving temporal networks and temporal link prediction methods have recently attracted increasing attention. In this study, for the first time, we examine the use of links between a pair of nodes to predict their common neighbors and analyze the relationship between the weight and the structure in static networks, evolving networks, and in the corresponding randomized networks. We propose both new unweighted and weighted prediction methods and use six kinds of real networks to test our algorithms. In unweighted networks, we find that if a pair of nodes connect to each other in the current network, they will have a higher probability to connect common nodes both in the current and the future networks-and the probability will decrease with the increase of the number of neighbors. Furthermore, we find that the original networks have their particular structure and statistical characteristics which benefit link prediction. In weighted networks, the prediction algorithm performance of networks which are dominated by human factors decrease with the decrease of weight and are in general better in static networks. Furthermore, we find that geographical position and link weight both have significant influence on the transport network. Moreover, the evolving financial network has the lowest predictability. In addition, we find that the structure of non-social networks has more robustness than social networks. The structure of engineering networks has both best predictability and also robustness.

  8. Simulating DNA coding sequence evolution with EvolveAGene 3.

    Science.gov (United States)

    Hall, Barry G

    2008-04-01

    Phylogenetic reconstruction based upon multiple alignments of molecular sequences is important to most branches of modern biology and is central to molecular evolution. Understanding the historical relationships among macromolecules depends upon computer programs that implement a variety of analytical methods. Because it is impossible to know those historical relationships with certainty, assessment of the accuracy of methods and the programs that implement them requires the use of programs that realistically simulate the evolution of DNA sequences. EvolveAGene 3 is a realistic coding sequence simulation program that separates mutation from selection and allows the user to set selection conditions, including variable regions of selection intensity within the sequence and variation in intensity of selection over branches. Variation includes base substitutions, insertions, and deletions. To the best of my knowledge, it is the only program available that simulates the evolution of intact coding sequences. Output includes the true tree and true alignments of the resulting coding sequence and corresponding protein sequences. A log file reports the frequencies of each kind of base substitution, the ratio of transition to transversion substitutions, the ratio of indel to base substitution mutations, and the numbers of silent and amino acid replacement mutations. The realism of the data sets has been assessed by comparing the d(N)/d(S) ratio, the ratio of transition to transversion substitutions, and the ratio of indel to base substitution mutations of the simulated data sets with those parameters of real data sets from the "gold standard" BaliBase collection of structural alignments. Results show that the data sets produced by EvolveAGene 3 are very similar to real data sets, and EvolveAGene 3 is therefore a realistic simulation program that can be used to evaluate a variety of programs and methods in molecular evolution.

  9. Breast cancer treatment: evolving approaches but stable results.

    Science.gov (United States)

    Chism, S E; Brown, B S; Hoyle, B A

    1986-12-01

    This report describes the outcome of 530 women with breast cancer diagnosed from 1968 through 1983 and represents a demographic population rather than a referred selected one. The data represents the results of evolving breast cancer treatment approaches during the past 2 decades and is particularly useful as a measure of the total population denominator, free of selection factors that confound reports detailing a surgical, radiation, or chemotherapy experience. During the time interval reviewed, the standard treatment approach of the primary changed from radical mastectomy to biopsy and radiation therapy. Chemotherapy policy evolved from single agent treatment for relapse to multiple drug programs as adjuvant or for relapse. The major findings were: The 5-, 10-, and 15-year survival rates for the intervals 1972-75, 1976-79, and 1980-83 were slightly better than the earliest interval 1968-71, but with no statistically significant improvement. The frequency of favorable disease (Stages Tis, 1) increased from 16 to 31 percent during the interval but the mean age remained the same suggesting that patient education programs, availability of health insurance, or mammography may have lead to identifying patients with more favorable disease. Mastectomy has been replaced by breast conserving surgery and radiation as the most common treatment of the primary. Patients treated by surgery and biopsy/radiation had identical survival outcomes. It was not possible to detect improved survival that could be ascribed to the adoption of multiple agent chemotherapy but the magnitude of the effect is calculated to be on the order of 2% of the total patient population diagnosed. Death due to breast cancer decreases with time after diagnosis but is still 4% per year, 10 years after treatment. The findings suggest that progress has been made in detection, breast conservation, and palliation of symptoms in many subpopulations, but the end results for the total breast cancer population have

  10. Partitioning the fitness components of RNA populations evolving in vitro.

    Directory of Open Access Journals (Sweden)

    Carolina Díaz Arenas

    Full Text Available All individuals in an evolving population compete for resources, and their performance is measured by a fitness metric. The performance of the individuals is relative to their abilities and to the biotic surroundings--the conditions under which they are competing--and involves many components. Molecules evolving in a test tube can also face complex environments and dynamics, and their fitness measurements should reflect the complexity of various contributing factors as well. Here, the fitnesses of a set of ligase ribozymes evolved by the continuous in vitro evolution system were measured. During these evolution cycles there are three different catalytic steps, ligation, reverse transcription, and forward transcription, each with a potential differential influence on the total fitness of each ligase. For six distinct ligase ribozyme genotypes that resulted from continuous evolution experiments, the rates of reaction were measured for each catalytic step by tracking the kinetics of enzymes reacting with their substrates. The reaction products were analyzed for the amount of product formed per time. Each catalytic step of the evolution cycle was found to have a differential incidence in the total fitness of the ligases, and therefore the total fitness of any ligase cannot be inferred from only one catalytic step of the evolution cycle. Generally, the ribozyme-directed ligation step tends to impart the largest effect on overall fitness. Yet it was found that the ligase genotypes have different absolute fitness values, and that they exploit different stages of the overall cycle to gain a net advantage. This is a new example of molecular niche partitioning that may allow for coexistence of more than one species in a population. The dissection of molecular events into multiple components of fitness provides new insights into molecular evolutionary studies in the laboratory, and has the potential to explain heretofore counterintuitive findings.

  11. Open-Ended Behavioral Complexity for Evolved Virtual Creatures

    DEFF Research Database (Denmark)

    Lessin, Dan; Fussell, Don; Miikkulainen, Risto

    2013-01-01

    use of high-level human input in the form of a syllabus of intermediate learning tasks--along with mechanisms for preservation, reuse, and combination of previously learned tasks. This method (named ESP for its three components: encapsulation, syllabus, and pandemonium) is employed to evolve a virtual...... creature with behavioral complexity that clearly exceeds previously achieved levels. ESP thus demonstrates that EVCs may indeed have the potential to one day rival the behavioral complexity--and therefore the entertainment value--of their non-virtual counterparts....

  12. Regenerative technologies to bed side: Evolving the regulatory framework

    Directory of Open Access Journals (Sweden)

    Daisuke Sakai

    2017-04-01

    Full Text Available There are high expectations for the clinical application of regenerative medicine technologies to treat musculoskeletal disorders. However, there are still big hurdles in bringing cell-based products to the market, mainly due to strict regulatory frameworks to approve these. Recently, the Japanese Pharmaceuticals and Medical Devices Agency adopted new regulations under legislature. The translational potential of this article is to inform on the regulations to bring experimental phase regenerative concepts to market approval in the United States and Europe, and highlight the opportunities granted by Japanese regulatory framework. Furthermore, we discuss the perspectives on the quickly evolving regulatory environment.

  13. Simulations of embodied evolving semiosis: Emergent semantics in artificial environments

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, L.M.; Joslyn, C.

    1998-02-01

    As we enter this amazing new world of artificial and virtual systems and environments in the context of human communities, we are interested in the development of systems and environments which have the capacity to grow and evolve their own meanings in the context of this community of interaction. In this paper the authors analyze the necessary conditions to achieve systems and environments with these properties: (1) a coupled interaction between a system and its environment; (2) an environment with sufficient initial richness and structure to allow for; (3) embodied emergent classification of that environment system coupling; and (4) which is subject to pragmatic selection.

  14. Evolving fuzzy systems from data streams in real-time

    OpenAIRE

    Angelov, Plamen; Zhou, Xiaowei

    2006-01-01

    An approach to real-time generation of fuzzy rule-base systems of extended Takagi-Sugeno (xTS) type from data streams is proposed in the paper. The xTS fuzzy system combines both zero and first order Takagi-Sugeno (TS) type systems. The fuzzy rule-base (system structure) evolves starting 'from scratch' based on the data distribution in the joint input/output data space. An incremental clustering procedure that takes into account the non-stationary nature of the data pattern and generates clus...

  15. Forces shaping the fastest evolving regions in the human genome

    DEFF Research Database (Denmark)

    Pollard, Katherine S; Salama, Sofie R; King, Bryan

    2006-01-01

    are dramatically changed in human but not in other primates, with seven times more substitutions in human than in chimp. The accelerated elements, and in particular the top five, show a strong bias for adenine and thymine to guanine and cytosine nucleotide changes and are disproportionately located in high...... contributed to accelerated evolution of the fastest evolving elements in the human genome.......Comparative genomics allow us to search the human genome for segments that were extensively changed in the last approximately 5 million years since divergence from our common ancestor with chimpanzee, but are highly conserved in other species and thus are likely to be functional. We found 202...

  16. Reforming marketing for sustainability: towards a framework for evolved marketing

    OpenAIRE

    Hurth, V; Peck, J.; Jackman, E; Wensing, E

    2015-01-01

    This paper seeks to provide guidance to the question ‘how can we evolve marketing so that it becomes a force for sustainability?’. Much useful advice has been produced on the how existing norms of marketing can be applied to the topic of sustainability – for example, taking the marketing ‘Ps’ and integrating a sustainability approach into each. Many people on the ground trying to implement ‘Sustainable Marketing’ find that there is much high-level enthusiasm for this kind of change, at a mana...

  17. On thin-shell wormholes evolving in flat FRW spacetimes

    CERN Document Server

    La Camera, M

    2011-01-01

    We analize the stability of a class of thin-shell wormholes with spherical symmetry evolving in flat FRW spacetimes. The wormholes considered here are supported at the throat by a perfect fluid with equation of state $\\mathcal{P}=w\\sigma$ and have a physical radius equal to $aR$, where $a$ is a time-dependent function describing the dynamics of the throat and $R$ is the background scale factor. The study of wormhole stability is done by means of the stability analysis of dynamic systems.

  18. Do metaphors evolve? The case of the social organism

    DEFF Research Database (Denmark)

    Mouton, Nicolaas T.O.

    2013-01-01

    A long line of philosophers and social scientists have defended and extended the curious idea that collective entities – states and societies, cities and corporations – are biological organisms. In this article, I study a few short but spectacular episodes from the history of that metaphor......, juxtapose mappings made in one era with correspondences conjured in other epochs, and reflect upon the reasons why they differ. By adopting a historical perspective on the process whereby the notion of a “social organism” evolved from its relatively simple beginnings in ancient philosophy to its rather...

  19. Adaptive synonymous mutations in an experimentally evolved Pseudomonas fluorescens population

    DEFF Research Database (Denmark)

    Bailey, Susan; Hinz, Aaron; Kassen, Rees

    2014-01-01

    Conventional wisdom holds that synonymous mutations, nucleotide changes that do not alter the encoded amino acid, have no detectable effect on phenotype or fitness. However, a growing body of evidence from both comparative and experimental studies suggests otherwise. Synonymous mutations have been...... in an experimentally evolved population of Pseudomonas fluorescens. We show experimentally that these mutations increase fitness by an amount comparable to non-synonymous mutations and that the fitness increases stem from increased gene expression. These results provide unequivocal evidence that synonymous mutations...... can drive adaptive evolution and suggest that this class of mutation may be underappreciated as a cause of adaptation and evolutionary dynamics....

  20. Metadata Evaluation and Improvement: Evolving Analysis and Reporting

    Science.gov (United States)

    Habermann, Ted; Kozimor, John; Gordon, Sean

    2017-01-01

    ESIP Community members create and manage a large collection of environmental datasets that span multiple decades, the entire globe, and many parts of the solar system. Metadata are critical for discovering, accessing, using and understanding these data effectively and ESIP community members have successfully created large collections of metadata describing these data. As part of the White House Big Earth Data Initiative (BEDI), ESDIS has developed a suite of tools for evaluating these metadata in native dialects with respect to recommendations from many organizations. We will describe those tools and demonstrate evolving techniques for sharing results with data providers.