WorldWideScience

Sample records for evaluation results update

  1. [Evaluation and management of enuresis. An update].

    Science.gov (United States)

    Riccabona, M

    2010-07-01

    Enuresis is defined as nocturnal bed wetting for at least 2 nights per month in children older than 5 years. At this age the prevalence of enuresis is about 15-20%. More than 50% of these children show day time symptoms, such as frequency, urgency and incontinence (non-monosymptomatic enuresis). The other children are asymptomatic during day time and wet the bed during the night time (monosymptomatic enuresis). The main pathogenetic factors are nycturia, detrusor overactivity and reduced arousability. Psychological and psychiatric aspects, genetics and obstipation play an additional role in the etiology. Basic diagnostic investigations are mandatory before treatment. Clinical history, physical examination, sonography of the urinary tract, urinalysis and bladder diary are prerequisites before any therapeutic steps are taken. The cornerstones of primary enuresis therapy are general lifestyle advice, pharmacotherapy and alarm devices. Therapy-resistant children deserve further evaluation and a multidisciplinary therapy approach. After careful evaluation specific therapy is efficient in approximately 80% of patients.

  2. Evaluating an approach to improving the adoption rate of wireless drug library updates for smart pumps.

    Science.gov (United States)

    Poppe, Lindsey B; Eckel, Stephen F

    2011-01-15

    An academic medical center's approach to improving the adoption rate of wireless drug library updates for smart pumps was evaluated. A multidisciplinary team composed of pharmacy, nursing, medical engineering, materials management, and patient equipment personnel at an academic medical center collaborated to update the drug libraries of more than 1800 smart pumps via a wireless control system. Two pilot tests were completed to identify and resolve issues before the live wireless update was attempted. The second pilot test, a passive approach, produced an adoption rate of 42% of 1804 pumps at the end of one week and a rate of 56% on day 10. The goal of 80% was not achieved until day 22. The change to an active multidisciplinary process three months later produced an adoption rate of 80% for 1869 pumps on day 10, resulting in a 45.4% increase in the adoption rate between the two trials on day 10 (p < 0.001). Communication regarding the updates was disseminated via e-mail to the entire organization, with fliers posted on all patient care units, and verbally during staff meetings. Patient equipment personnel manually tagged each pump with a blue zip tie after verifying the update to easily identify which pumps had been updated. Areas for improvement include increasing communication to the staff detailing when the update will occur and changing the day of the week the update is performed. A multidisciplinary team actively engaged in the updating of wireless i.v. smart pump drug libraries reduced the amount of time required to reach a goal adoption rate of 80%.

  3. Update of GALLEX solar neutrino results and implications

    Energy Technology Data Exchange (ETDEWEB)

    Kirsten, T. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany)

    1995-01-01

    The galliumchloride detector operated by the GALLEX-collaboration in the Gran Sasso Underground Laboratory responds primarily to pp-neutrinos. They are produced in the primary fusion reaction of hydrogen into deuterium and directly coupled to the solar luminosity. Standard Solar Models predict ca. 58% of the total signal expected in GALLEX (123-132 SNU) to be due to pp-neutrinos. The relative pp-neutrino dominance becomes even larger if the deficit of higher energy neutrinos (as observed in the Homestake- and Kamiokande experiments) is considered. During the first data taking period, 15 solar runs had been performed within the exposure period 14.5.1991 - 29.4.1992. The result, 81 {+-} 17 {+-} 9 SNU provided the first experimental evidence for pp-neutrinos from the Sun. At the same time, it confirmed the depression of higher energy neutrino fluxes relative to the model predictions. Here the authors report the results of 15 more solar neutrino runs, covering the period 19.8.92 - 13.10.93. They obtain 78 {+-} 13 {+-} 5 SNU. Evaluated together, the result for all 30 runs is 79 {+-} 10 {+-} 6 SNU. While the SNU rate of GALLEX I is well reproduced the statistical error has been reduced so substantially that a value of signal +2{sigma} is required to accommodate not only pp-and pep- but also the {sup 7}Be-neutrino induced {sup 71}Ge-production. Contrary, the fate of {sup 8}B-neutrinos has only little discernible effect on the GALLEX data. In conclusion, with the present errors GALLEX constitutes a 2.5 {sigma} problem for {sup 7}Be neutrinos within the frame of {open_quotes}astrophysical{close_quotes} solutions. Alternatively, the particle physics solution (MSW-effect) can consistently explain all available solar neutrino results, leading to a most probable mass scale with the muon-neutrino at approximately 3 meV (milli-eV). However, since the GALLEX result allows the presence of pp and pep neutrinos at full strength. the latter explanation of the data is not forced.

  4. Revised and updated paleomagnetic results from Costa Rica

    Science.gov (United States)

    Cromwell, G.; Constable, C. G.; Staudigel, H.; Tauxe, L.; Gans, P.

    2013-09-01

    Paleomagnetic results from globally distributed lava flows have been collected and analyzed under the time-averaged field initiative (TAFI), a multi-institutional collaboration started in 1996 and designed to improve the geographic and temporal coverage of the 0-5 Ma paleomagnetic database for studying both the time-averaged field and its very long-term secular variations. Paleomagnetic samples were collected from 35 volcanic units, either lava flows or ignimbrites, in Costa Rica in December 1998 and February 2000 from the Cordilleras Central and Guanacaste, the underlying Canas, Liberia and Bagaces formations and from Volcano Arenal. Age estimates range from approximately 40 ka to slightly over 6 Ma. Although initial results from these sites were used in a global synthesis of TAFI data by Johnson et al. (2008), a full description of methodology was not presented. This paper documents the definitive collection of results comprising 28 paleomagnetic directions (24 normal, 4 reversed), with enhanced precision and new geological interpretations, adding two paleointensity estimates and 19 correlated 40Ar/39Ar radiometric ages. The average field direction is consistent with that of a geocentric axial dipole and dispersion of virtual geomagnetic poles (17.3 ± 4.6°) is in general agreement with predictions from several statistical paleosecular variation models. Paleointensity estimates from two sites give an average field strength of 26.3 μT and a virtual axial dipole moment of 65 ZAm2. The definitive results provide a useful augmentation of the global database for the longer term goal of developing new statistical descriptions of paleomagnetic field behavior.

  5. Evaluation and Comparison of Discovery Tools: An Update

    Directory of Open Access Journals (Sweden)

    F. William Chickering

    2014-06-01

    Full Text Available Abstract: Selection and implementation of a web scale Discovery tool by The Rider University Libraries (RUL in the 2011-2012 academic year revealed the practical complexity of the endeavor. Research into the state of adoption of Web-scale Discovery tools in North America and the evolution of product effectiveness provided a starting point. The study reported here evaluated a total of 14 major Discovery tools (3 open source and 10 proprietary. The evaluation involves a check list of 16 criteria recognized as the advanced features of a modern OPAC. Some of the features have been used in previous research on Discovery tools and the next generation catalog. The authors examined 5 to 7 library websites that deployed a Discovery tool before a determination is made as to the presence or absence of a feature for a particular Discovery tool. The purpose of the study is to evaluate and compare all the major Discovery tools. These findings will serve to update librarians on the latest development in the library user interface and assist them in their adoption of a Discovery tool.

  6. An updated evaluation of the Bonn Agreement: incorporating the Marrakesh Accords

    NARCIS (Netherlands)

    Elzen M den; Moor de A; CIM; MNV

    2002-01-01

    This report updates RIVM's earlier evaluation of the Bonn Agreement by incorporating the impact of the Marrakesh Accords. Compared to our previous report, the impact on both the environmental effectiveness and economic efficiency is rather limited. Our updated evaluation underlines the main

  7. An update of "Cost-effectiveness of rotavirus vaccination in the Netherlands : the results of a Consensus Rotavirus Vaccine model"

    NARCIS (Netherlands)

    Tu, Hong Anh T.; Rozenbaum, Mark H.; de Boer, Pieter T.; Noort, Albert C.; Postma, Maarten J.

    2013-01-01

    Background: To update a cost-effectiveness analysis of rotavirus vaccination in the Netherlands previously published in 2011.Methods: The rotavirus burden of disease and the indirect protection of older children and young adults (herd protection) were updated.Results: When updated data was used,

  8. Results Evaluation in Reduction Rhinoplasty

    Directory of Open Access Journals (Sweden)

    Arima, Lisandra Megumi

    2011-01-01

    Full Text Available Introduction: Final results evaluation after rhinoplasty is a not a topic widely studied from the patient's viewpoint. Objective:Evaluate the satisfaction of the patients submitted to reduction rhinoplasty, from the questionnaire Rhinoplasty Outcomes Evaluation (ROE. Method: Longitudinal study, retrospective cut type, of the preoperative and postoperative satisfaction. The sample was composed by 28 patients who were submitted to rhinoplasty and answered the ROE questionnaire. Three variables were obtained: satisfaction note that the patient had with his/her image before the surgery; note of satisfaction with the current appearance; the difference of the average satisfaction notes between postoperative and preoperative approaches. Results: The postoperative note was higher than the preoperative in all patients. We noticed a difference between the average of the postoperative and preoperative of 48.3 (p75 considered to be an excellent outcome (67.9%. Conclusions: The ROE questionnaire is a helpful tool to show the satisfaction of the patient submitted to reduction rhinoplasty. About 92% of the patients submitted to reduction rhinoplasty consider the postoperative result to be good or excellent.

  9. Effective Filtering of Query Results on Updated User Behavioral Profiles in Web Mining.

    Science.gov (United States)

    Sadesh, S; Suganthe, R C

    2015-01-01

    Web with tremendous volume of information retrieves result for user related queries. With the rapid growth of web page recommendation, results retrieved based on data mining techniques did not offer higher performance filtering rate because relationships between user profile and queries were not analyzed in an extensive manner. At the same time, existing user profile based prediction in web data mining is not exhaustive in producing personalized result rate. To improve the query result rate on dynamics of user behavior over time, Hamilton Filtered Regime Switching User Query Probability (HFRS-UQP) framework is proposed. HFRS-UQP framework is split into two processes, where filtering and switching are carried out. The data mining based filtering in our research work uses the Hamilton Filtering framework to filter user result based on personalized information on automatic updated profiles through search engine. Maximized result is fetched, that is, filtered out with respect to user behavior profiles. The switching performs accurate filtering updated profiles using regime switching. The updating in profile change (i.e., switches) regime in HFRS-UQP framework identifies the second- and higher-order association of query result on the updated profiles. Experiment is conducted on factors such as personalized information search retrieval rate, filtering efficiency, and precision ratio.

  10. Effective Filtering of Query Results on Updated User Behavioral Profiles in Web Mining

    Directory of Open Access Journals (Sweden)

    S. Sadesh

    2015-01-01

    Full Text Available Web with tremendous volume of information retrieves result for user related queries. With the rapid growth of web page recommendation, results retrieved based on data mining techniques did not offer higher performance filtering rate because relationships between user profile and queries were not analyzed in an extensive manner. At the same time, existing user profile based prediction in web data mining is not exhaustive in producing personalized result rate. To improve the query result rate on dynamics of user behavior over time, Hamilton Filtered Regime Switching User Query Probability (HFRS-UQP framework is proposed. HFRS-UQP framework is split into two processes, where filtering and switching are carried out. The data mining based filtering in our research work uses the Hamilton Filtering framework to filter user result based on personalized information on automatic updated profiles through search engine. Maximized result is fetched, that is, filtered out with respect to user behavior profiles. The switching performs accurate filtering updated profiles using regime switching. The updating in profile change (i.e., switches regime in HFRS-UQP framework identifies the second- and higher-order association of query result on the updated profiles. Experiment is conducted on factors such as personalized information search retrieval rate, filtering efficiency, and precision ratio.

  11. Decay Data Evaluation Project (DDEP): Updated decay data evaluations for (24)Na, (46)Sc, (51)Cr, (54)Mn, (57)Co, (59)Fe, (88)Y, (198)Au.

    Science.gov (United States)

    Chechev, Valery P; Kuzmenko, Nikolay K

    2016-03-01

    Updated DDEP evaluations have been presented for the decay characteristics of the radionuclides (24)Na, (46)Sc, (51)Cr, (54)Mn, (57)Co, (59)Fe, (88)Y and (198)Au. Previous DDEP evaluations for these radionuclides were published in the BIPM-5 monographie in 2004. The experimental data published during the intervening period of 2004-2014 were taken into account in the current evaluations as well as other information: new compilations, analyses, and corrections. The updated evaluations are compared to previous results. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. A Performance Evaluation of Online Warehouse Update Algorithms

    Science.gov (United States)

    1998-01-01

    able to present a fully consistent ver- sion of the warehouse to the queries while the warehouse is being updated. Multiversioning has been used...LST97]). Special- ized multiversion access structures have also been proposed ([LS89, LS90, dBS96, BC97, VV97, MOPW98]) In the context of OLTP systems...collection processes. 2.1 Multiversioning MVNL supports multiple versions by using Time Travel ([Sto87]). Each row has two extra at- tributes, Tmin

  13. Summary of Expansions, Updates, and Results in GREET® 2016 Suite of Models

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-10-01

    This report documents the technical content of the expansions and updates in Argonne National Laboratory’s GREET® 2016 release and provides references and links to key documents related to these expansions and updates.

  14. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    Directory of Open Access Journals (Sweden)

    Marcin Luczak

    2014-01-01

    Full Text Available This paper presents selected results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study of the structural dynamics of a bend-twist coupled full scale section of a wind turbine blade structure. The main goal of the conducted research is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set of model parameters was selected for the model updating process. Design of experiment and response surface method was implemented to find values of model parameters yielding results closest to the experimental. The updated finite element model is producing results more consistent with the measurement outcomes.

  15. Update of ENDL U(n,2n), U(n,gamma), U(n,f) Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Beck, B; Brown, D A; McNabb, D P

    2004-02-13

    The authors are in the re-evaluating of all the actinide cross section evaluations in LLNL's ENDL database, starting with uranium and focusing on inventory changing reactions. This article describes their first serious pass at updating the uranium cross section data, including estimates of cross section uncertainties. Furthermore, they are developing new tools to automate the re-evaluation and this article contains some preliminary results from these codes, namely the {sup 235}U(n, 2n) and {sup 238}U(n, 2n) evaluations.

  16. Updated Performance Evaluation of the ISS Water Processor Multifiltration Beds

    Science.gov (United States)

    Bowman, Elizabeth M.; Carter, Layne; Carpenter, Joyce; Orozco, Nicole; Weir, Natalee; Wilson, Mark

    2014-01-01

    The ISS Water Processor Assembly (WPA) produces potable water from a waste stream containing humidity condensate and urine distillate. The primary treatment process is achieved in the Multifiltration Beds, which include adsorbent media and ion exchange resin for the removal of dissolved organic and inorganic contaminants. Two Multifiltration Beds (MF Beds) were replaced on ISS in July 2010 after initial indication of inorganic breakthrough of the first bed and an increasing Total Organic Carbon (TOC) trend in the product water. The first bed was sampled and analyzed Sept 2011 through March 2012. The second MF Bed was sampled and analyzed June 2012 through August 2012. The water resident in the both beds was analyzed for various parameters to evaluate adsorbent loading, performance of the ion exchange resin, microbial activity, and generation of leachates from the ion exchange resin. Portions of the adsorbent media and ion exchange resin were sampled and subsequently desorbed to identify the primary contaminants removed at various points in the bed in addition to microbial analysis. Analysis of the second bed will be compared to results from the first bed to provide a comprehensive overview of how the Multifiltration Beds function on orbit. New data from the second bed supplements the analysis of the first bed (previously reported) and gives a more complete picture of breakthrough compounds, resin breakdown products, microbial activity, and difficult to remove compounds. The results of these investigations and implications to the operation of the WPA on ISS are documented in this paper.

  17. Evaluation of Lower East Fork Poplar Creek Mercury Sources - Model Update

    Energy Technology Data Exchange (ETDEWEB)

    Ketelle, Richard [East Tennessee Technology Park (ETTP), Oak Ridge, TN (United States); Brandt, Craig C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peterson, Mark J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Watson, David B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Brooks, Scott C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mayes, Melanie [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeRolph, Christopher R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dickson, Johnbull O. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Olsen, Todd A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    The purpose of this report is to assess new data that has become available and provide an update to the evaluations and modeling presented in the Oak Ridge National Laboratory (ORNL) Technical Manuscript Evaluation of lower East Fork Poplar Creek (LEFPC) Mercury Sources (Watson et al., 2016). Primary sources of field and laboratory data for this update include multiple US Department of Energy (DOE) programs including Environmental Management (EM; e.g., Biological Monitoring and Abatement Program, Mercury Remediation Technology Development [TD], and Applied Field Research Initiative), Office of Science (Mercury Science Focus Areas [SFA] project), and the Y-12 National Security Complex (Y-12) Compliance Department.

  18. Performance of two updated blood glucose monitoring systems: an evaluation following ISO 15197:2013.

    Science.gov (United States)

    Pleus, Stefan; Baumstark, Annette; Rittmeyer, Delia; Jendrike, Nina; Haug, Cornelia; Freckmann, Guido

    2016-05-01

    Objective For patients with diabetes, regular self-monitoring of blood glucose (SMBG) is essential to ensure adequate glycemic control. Therefore, accurate and reliable blood glucose measurements with SMBG systems are necessary. The international standard ISO 15197 describes requirements for SMBG systems, such as limits within which 95% of glucose results have to fall to reach acceptable system accuracy. The 2013 version of this standard sets higher demands, especially regarding system accuracy, than the currently still valid edition. ISO 15197 can be applied by manufacturers to receive a CE mark for their system. Research design and methods This study was an accuracy evaluation following ISO 15197:2013 section 6.3 of two recently updated SMBG systems (Contour * and Contour TS; Bayer Consumer Care AG, Basel, Switzerland) with an improved algorithm to investigate whether the systems fulfill the requirements of the new standard. For this purpose, capillary blood samples of approximately 100 participants were measured with three test strip lots of both systems and deviations from glucose values obtained with a hexokinase-based comparison method (Cobas Integra † 400 plus; Roche Instrument Center, Rotkreuz, Switzerland) were determined. Percentages of values within the acceptance criteria of ISO 15197:2013 were calculated. This study was registered at clinicaltrials.gov (NCT02358408). Main outcome Both updated systems fulfilled the system accuracy requirements of ISO 15197:2013 as 98.5% to 100% of the results were within the stipulated limits. Furthermore, all results were within the clinically non-critical zones A and B of the consensus error grid for type 1 diabetes. Conclusions The technical improvement of the systems ensured compliance with ISO 15197 in the hands of healthcare professionals even in its more stringent 2013 version. Alternative presentation of system accuracy results in radar plots provides additional information with certain advantages. In addition

  19. Update in the evaluation of the azoospermic male

    Directory of Open Access Journals (Sweden)

    Ahmet Gudeloglu

    2013-01-01

    Full Text Available Approximately 1% of all men in the general population suffer from azoospermia, and azoospermic men constitute approximately 10 to 15% of all infertile men. Thus, this group of patients represents a significant population in the field of male infertility. A thorough medical history, physical examination and hormonal profile are essential in the evaluation of azoospermic males. Imaging studies, a genetic workup and a testicular biopsy (with cryopreservation may augment the workup and evaluation. Men with nonobstructive azoospermia should be offered genetic counseling before their spermatozoa are used for assisted reproductive techniques. This article provides a contemporary review of the evaluation of the azoospermic male.

  20. Evaluation and Comparison of Discovery Tools: An Update

    OpenAIRE

    F. William Chickering; Yang, Sharon Q.

    2014-01-01

    Abstract: Selection and implementation of a web scale Discovery tool by The Rider University Libraries (RUL) in the 2011-2012 academic year revealed the practical complexity of the endeavor. Research into the state of adoption of Web-scale Discovery tools in North America and the evolution of product effectiveness provided a starting point. The study reported here evaluated a total of 14 major Discovery tools (3 open source and 10 proprietary). The evaluation involves a check list of 16 crite...

  1. Chapter 1 Evaluation & Reporting System, 1989 Update. Technical Report No. 9013.

    Science.gov (United States)

    Davidoff, Stephen H.

    This technical report updates the Chapter 1 Evaluation and Reporting System (CHIERS) used by the Philadelphia (Pennsylvania) School District to gather and report student information related to compensatory education programs funded under Chapter 1 of the Education Consolidation and Improvement Act of 1981, with information about 1988-89 projects.…

  2. Chapter 1 Evaluation and Reporting System (CHIERS) 1988 Update. Technical Report No. 8903.

    Science.gov (United States)

    Davidoff, Stephen H.; Fishman, Roger J.

    The Chapter 1 Evaluation and Reporting System (CHIERS) is an annually updated system for gathering and reporting student information regarding the Education Consolidation and Improvement Act Chapter 1 program in the Philadelphia (Pennsylvania) School District. Data elements included in the CHIERS are school location, achievement test scores, and…

  3. Medical Evaluation of Suspected Child Sexual Abuse: 2011 Update

    Science.gov (United States)

    Adams, Joyce A.

    2011-01-01

    The medical evaluation of children with suspected sexual abuse includes more than just the physical examination of the child. The importance of taking a detailed medical history from the parents and a history from the child about physical sensations following sexual contact has been emphasized in other articles in the medical literature. The…

  4. [Update on current care guidelines: evaluation and treatment of menorrhagia].

    Science.gov (United States)

    2010-01-01

    Diagnosis of menorrhagia is based on an evaluation of the bleeding volume and its harm to the patient. The appropriate treatment of menorrhagia improves patients' quality of life. Medical treatment, including an intrauterine system (IUS), tranexamic acid, NSAIDs or contraceptive pills, should usually be tried before surgical treatment.

  5. Planck 2013 results. XXXII. The updated Planck catalogue of Sunyaev-Zeldovich sources

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

    2015-01-01

    We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catal...

  6. Decay data evaluation project (DDEP): updated evaluations of the 233Th and 241Am decay characteristics.

    Science.gov (United States)

    Chechev, Valery P; Kuzmenko, Nikolay K

    2010-01-01

    The results of new decay data evaluations are presented for (233)Th (beta(-)) decay to nuclear levels in (233)Pa and (241)Am (alpha) decay to nuclear levels in (237)Np. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2009. Copyright 2009 Elsevier Ltd. All rights reserved.

  7. Summary of Expansions, Updates, and Results in GREET 2017 Suite of Models

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Michael [Argonne National Lab. (ANL), Argonne, IL (United States); Elgowainy, Amgad [Argonne National Lab. (ANL), Argonne, IL (United States); Han, Jeongwoo [Argonne National Lab. (ANL), Argonne, IL (United States); Benavides, Pahola Thathiana [Argonne National Lab. (ANL), Argonne, IL (United States); Burnham, Andrew [Argonne National Lab. (ANL), Argonne, IL (United States); Cai, Hao [Argonne National Lab. (ANL), Argonne, IL (United States); Canter, Christina [Argonne National Lab. (ANL), Argonne, IL (United States); Chen, Rui [Argonne National Lab. (ANL), Argonne, IL (United States); Dai, Qiang [Argonne National Lab. (ANL), Argonne, IL (United States); Kelly, Jarod [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, Dong-Yeon [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, Uisung [Argonne National Lab. (ANL), Argonne, IL (United States); Li, Qianfeng [Argonne National Lab. (ANL), Argonne, IL (United States); Lu, Zifeng [Argonne National Lab. (ANL), Argonne, IL (United States); Qin, Zhangcai [Argonne National Lab. (ANL), Argonne, IL (United States); Sun, Pingping [Argonne National Lab. (ANL), Argonne, IL (United States); Supekar, Sarang D. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-11-01

    This report provides a technical summary of the expansions and updates to the 2017 release of Argonne National Laboratory’s Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation (GREET®) model, including references and links to key technical documents related to these expansions and updates. The GREET 2017 release includes an updated version of the GREET1 (the fuel-cycle GREET model) and GREET2 (the vehicle-cycle GREET model), both in the Microsoft Excel platform and in the GREET.net modeling platform. Figure 1 shows the structure of the GREET Excel modeling platform. The .net platform integrates all GREET modules together seamlessly.

  8. Aerodynamic flight evaluation analysis and data base update

    Science.gov (United States)

    Boyle, W. W.; Miller, M. S.; Wilder, G. O.; Reheuser, R. D.; Sharp, R. S.; Bridges, G. I.

    1989-01-01

    Research was conducted to determine the feasibility of replacing the Solid Rocket Boosters on the existing Space Shuttle Launch Vehicle (SSLV) with Liquid Rocket Boosters (LRB). As a part of the LRB selection process, a series of wind tunnel tests were conducted along with aero studies to determine the effects of different LRB configurations on the SSLV. Final results were tabulated into increments and added to the existing SSLV data base. The research conducted in this study was taken from a series of wind tunnel tests conducted at Marshall's 14-inch Trisonic Wind Tunnel. The effects on the axial force (CAF), normal force (CNF), pitching moment (CMF), side force (CY), wing shear force (CSR), wing torque moment (CTR), and wing bending moment (CBR) coefficients were investigated for a number of candidate LRB configurations. The aero effects due to LRB protuberances, ET/LRB separation distance, and aft skirts were also gathered from the tests. Analysis was also conducted to investigate the base pressure and plume effects due to the new booster geometries. The test results found in Phases 1 and 2 of wind tunnel testing are discussed and compared. Preliminary LRB lateral/directional data results and trends are given. The protuberance and gap/skirt effects are discussed. The base pressure/plume effects study is discussed and results are given.

  9. Decay Data Evaluation Project (DDEP): Updated evaluation of the 133Ba, 140Ba, 140La and 141Ce decay characteristics

    Science.gov (United States)

    Chechev, Valerii P.; Kuzmenko, Nikolai K.

    2017-09-01

    Within the Decay Data Evaluation Project (DDEP) an updated comprehensive assessment has been made of the decay characteristics of 133Ba, 140Ba, 140La, and 141Ce. Experimental data published up to 2016 along with other information (new compilations, analyses and corrections) were taken into account. Newly evaluated values of the half-lives and a number of other key decay characteristics are presented in this paper for all four radionuclides.

  10. Updated comparison of groundwater flow model results and isotopic data in the Leon Valley, Mexico

    Science.gov (United States)

    Hernandez-Garcia, G. D.

    2015-12-01

    Northwest of Mexico City, the study area is located in the State of Guanajuato. Leon Valley has covered with groundwater its demand of water, estimated in 20.6 cubic meters per second. The constant increase of population and economic activities in the region, mainly in cities and automobile factories, has also a constant growth in water needs. Related extraction rate has produced an average decrease of approximately 1.0 m per year over the past two decades. This suggests that the present management of the groundwater should be checked. Management of groundwater in the study area involves the possibility of producing environmental impacts by extraction. This vital resource under stress becomes necessary studying its hydrogeological functioning to achieve scientific management of groundwater in the Valley. This research was based on the analysis and integration of existing information and the field generated by the authors. On the base of updated concepts like the geological structure of the area, the hydraulic parameters and the composition of deuterium-delta and delta-oxygen -18, this research has new results. This information has been fully analyzed by applying a groundwater flow model with particle tracking: the result has also a similar result in terms of travel time and paths derived from isotopic data.

  11. AERMOD: MODEL FORMULATION AND EVALUATION RESULTS

    Science.gov (United States)

    AERMOD is an advanced plume model that incorporates updated treatments of the boundary layer theory, understanding of turbulence and dispersion, and includes handling of terrain interactions. This paper presents an overview of AERMOD's features relative to ISCST3. AERM...

  12. Semi-natural test methods to evaluate fire safety of wall claddings: Update

    Directory of Open Access Journals (Sweden)

    Smolka Miroslav

    2016-01-01

    Full Text Available There are a number of test methods worldwide to evaluate fire safety of facades. An overview of available test methods implemented in fire safety codes was presented at the 1st Conference of Fire Safety of Facades in 2013. [1] Since then, a number of changes and developments occurred. The purpose of this paper is to present the updated global overview of facade fire spread test methods made for building regulations.

  13. Evaluation of Results from Sales Promotion Activities

    Directory of Open Access Journals (Sweden)

    Olimpia Ban

    2007-02-01

    Full Text Available An essential element of the sales promotion strategy and not only is the evaluation of the results obtained from the activities performed. Due to their nature and applicability, the evaluation of the sales promotion is much easier to be achieved, but it raises some problems. Using a hypothetical example, we have tried to develop a "classic" evaluation model of the specialty literature.

  14. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.

    LENUS (Irish Health Repository)

    Campbell, E

    2014-09-01

    Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine.

  15. Building an evaluative culture for effective evaluation and results management

    OpenAIRE

    Mayne, John

    2008-01-01

    A weak evaluative culture undermines many attempts at building an effective evaluation and results management regime. This brief outlines practical actions that an organization can take to build and support an evaluative culture, where information on performance is deliberately sought in order to learn how to better manage and deliver programmes and services. Such an organization values empirical evidence on the results it is seeking to achieve.

  16. Multi-shaped beam: development status and update on lithography results

    Science.gov (United States)

    Slodowski, Matthias; Doering, Hans-Joachim; Dorl, Wolfgang; Stolberg, Ines A.

    2011-04-01

    According to the ITRS [1] photo mask is a significant challenge for the 22nm technology node requirements and beyond. Mask making capability and cost escalation continue to be critical for future lithography progress. On the technological side mask specifications and complexity have increased more quickly than the half-pitch requirements on the wafer designated by the roadmap due to advanced optical proximity correction and double patterning demands. From the economical perspective mask costs have significantly increased each generation, in which mask writing represents a major portion. The availability of a multi-electron-beam lithography system for mask write application is considered a potential solution to overcome these challenges [2, 3]. In this paper an update of the development status of a full-package high-throughput multi electron-beam writer, called Multi Shaped Beam (MSB), will be presented. Lithography performance results, which are most relevant for mask writing applications, will be disclosed. The MSB technology is an evolutionary development of the matured single Variable Shaped Beam (VSB) technology. An arrangement of Multi Deflection Arrays (MDA) allows operation with multiple shaped beams of variable size, which can be deflected and controlled individually [4]. This evolutionary MSB approach is associated with a lower level of risk and a relatively short time to implementation compared to the known revolutionary concepts [3, 5, 6]. Lithography performance is demonstrated through exposed pattern. Further details of the substrate positioning platform performance will be disclosed. It will become apparent that the MSB operational mode enables lithography on the same and higher performance level compared to single VSB and that there are no specific additional lithography challenges existing beside those which have already been addressed [1].

  17. Scaling Research Results: Design and Evaluation | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Scaling Research Results: Design and Evaluation. Canada's International Development Research Centre (IDRC) supports research to seek scalable solutions to improve the lives of people in the developing world. While there is general understanding of the meaning of "scaling up/ within the domain of research for ...

  18. Updated results from E03103: A Measurement of the EMC Effect in Hall C at Jefferson Lab

    Science.gov (United States)

    Gaskell, Dave; E03103 Collaboration Collaboration

    2017-09-01

    The nuclear modification of inelastic structure functions (the EMC Effect) has been measured extensively in the more than 30 years since its discovery. Jefferson Lab results from the measurement of the EMC Effect in light nuclei (E03103) demonstrated that the EMC effect does not follow a simple dependence on average nuclear density, but instead might depend on the local nuclear density. This talk will present an updated analysis of the Jefferson Lab results from light nuclei, along with EMC ratios from heavier targets from the same experiment. The updated Jefferson Lab results will also be compared to existing data on measurements of Short Range Correlations (SRCs) to examine the impact on the previously observed EMC-SRC correlation. Supported in part by the U.S. Department of Energy, Contract Number AC05-06OR23177, under which Jefferson Science Associates, LLC operates Thomas Jefferson National Accelerator Facility.

  19. Summary of evidence-based guideline update: Evaluation and management of concussion in sports

    Science.gov (United States)

    Giza, Christopher C.; Kutcher, Jeffrey S.; Ashwal, Stephen; Barth, Jeffrey; Getchius, Thomas S.D.; Gioia, Gerard A.; Gronseth, Gary S.; Guskiewicz, Kevin; Mandel, Steven; Manley, Geoffrey; McKeag, Douglas B.; Thurman, David J.; Zafonte, Ross

    2013-01-01

    Objective: To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What diagnostic tools identify those with concussion and those at increased risk for severe/prolonged early impairments, neurologic catastrophe, or chronic neurobehavioral impairment? 3) What clinical factors identify those at increased risk for severe/prolonged early postconcussion impairments, neurologic catastrophe, recurrent concussions, or chronic neurobehavioral impairment? 4) What interventions enhance recovery, reduce recurrent concussion risk, or diminish long-term sequelae? The complete guideline on which this summary is based is available as an online data supplement to this article. Methods: We systematically reviewed the literature from 1955 to June 2012 for pertinent evidence. We assessed evidence for quality and synthesized into conclusions using a modified Grading of Recommendations Assessment, Development and Evaluation process. We used a modified Delphi process to develop recommendations. Results: Specific risk factors can increase or decrease concussion risk. Diagnostic tools to help identify individuals with concussion include graded symptom checklists, the Standardized Assessment of Concussion, neuropsychological assessments, and the Balance Error Scoring System. Ongoing clinical symptoms, concussion history, and younger age identify those at risk for postconcussion impairments. Risk factors for recurrent concussion include history of multiple concussions, particularly within 10 days after initial concussion. Risk factors for chronic neurobehavioral impairment include concussion exposure and APOE ε4 genotype. Data are insufficient to show that any intervention enhances recovery or diminishes long-term sequelae postconcussion. Practice recommendations are presented for preparticipation counseling, management of suspected concussion, and management of

  20. Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm

    DEFF Research Database (Denmark)

    Thyssen, Jacob Pontoppidan; Menné, Torkil; Elberling, Jesper

    2008-01-01

    of patients suspected with immediate- and delayed-type immune reactions. Literature was examined using PubMed-Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate-type and delayed-type allergic immune reactions.......Local anaesthetics (LA) are widely used drugs. Adverse reactions are rare but may be caused by delayed-type hypersensitivity reactions and probably also immediate-type reactions. As it is not always easy to clinically differ between these subtypes, allergy skin testing should be considered....... Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation...

  1. Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm

    DEFF Research Database (Denmark)

    Thyssen, Jacob Pontoppidan; Menné, Torkil; Elberling, Jesper

    2008-01-01

    Local anaesthetics (LA) are widely used drugs. Adverse reactions are rare but may be caused by delayed-type hypersensitivity reactions and probably also immediate-type reactions. As it is not always easy to clinically differ between these subtypes, allergy skin testing should be considered....... Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation...... of patients suspected with immediate- and delayed-type immune reactions. Literature was examined using PubMed-Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate-type and delayed-type allergic immune reactions....

  2. Breast elasticity: principles, technique, results: an update and overview of commercially available software.

    Science.gov (United States)

    Balleyguier, C; Canale, S; Ben Hassen, W; Vielh, P; Bayou, E H; Mathieu, M C; Uzan, C; Bourgier, C; Dromain, C

    2013-03-01

    Breast ultrasound elasticity evaluation has become a routine tool in addition to diagnostic ultrasound during the last five years. Two elasticity evaluation modes are currently available: free-hand elastography and shear-wave elastography (SWE). Most of the commercially available elastography scanners have specific procedures which must be understood by the users. Free-hand elastography usually displays qualitative imaging such as an elastogram, but most of the companies now use it to quantify the relative stiffness between a lesion and the surrounding breast tissue. SWE is a new mode theoretically independent of the sonographer which displays more quantitative information, and can be useful for characterizing breast lesions. Recent studies on elastography suggest that elasticity imaging can increase B-mode accuracy and specificity in differentiating benign and malignant breast lesions. This functional imaging mode could help reduce the number of biopsies performed for benign breast lesions. This review gives a detailed description of the main commercially available systems and the results of current applications in the evaluation of breast elasticity. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  3. Validation and Reproducibility of the Updated French Causality Assessment Method: an Evaluation by Pharmacovigilance Centres & Pharmaceutical Companies.

    Science.gov (United States)

    Théophile, Hélène; Dutertre, Jean-Paul; Gérardin, Marie; Valnet-Rabier, Marie-Blanche; Bidault, Irène; Guy, Claire; Haramburu, Françoise; Hillaire-Buys, Dominique; Méglio, Carmine; Arimone, Yannick

    2015-01-01

    Assess the validity and reproducibility of the updated version of the French causality assessment method in conditions approaching real-life use. A random sample of 31 drug-event pairs from the French pharmacovigilance database was assessed by the consensual judgement of three experts (gold standard). Separately, a team from a pharmacovigilance centre (PhVC) and another from a pharmaceutical company assessed these pairs using the current method, then with the updated method. To test the inter- and intra-rater reproducibility, two seniors and two juniors from a PhVC and a pharmaceutical company assessed the pairs twice with the updated method. A weighted kappa coefficient was used to measure the agreement of the two causality assessment methods with the consensual expert judgement (validity) as well as the agreement of the updated causality assessment over time (intra-rater reproducibility) and between evaluators (inter-rater reproducibility). Agreement between the current method and consensual expert judgement was fair for the PhVC team (weighted kappa [Kw] 0.33) and moderate for the pharmaceutical company team (Kw 0.41). For the updated method, agreement was better for both the PhVC (Kw 0.58) and the pharmaceutical company (Kw 0.52) teams. The inter- and intra-rater reproducibility of the updated method based on the intrinsic imputability was satisfactory overall (Kw 0.30-0.91). Discrepancies between evaluations from PhVC and pharmaceutical companies were observed with the updated method. The updated method performed better than the current one for drug causality assessment, suggesting that it should be used in routine pharmacovigilance. © 2015 Société Française de Pharmacologie et de Thérapeutique.

  4. Non-contact ultrasonic guided wave inspection of rails: field test results and updates

    Science.gov (United States)

    Mariani, Stefano; Nguyen, Thompson V.; Zhu, Xuan; Lanza di Scalea, Francesco; Fateh, Mahmood

    2015-04-01

    The University of California at San Diego (UCSD), under a Federal Railroad Administration (FRA) Office of Research and Development (R&D) grant, is developing a system for high-speed and non-contact rail defect detection. A prototype using an ultrasonic air-coupled guided wave signal generation and air-coupled signal detection, paired with a real-time statistical analysis algorithm, has been realized. This system requires a specialized filtering approach based on electrical impedance matching due to the inherently poor signal-to-noise ratio of air-coupled ultrasonic measurements in rail steel. Various aspects of the prototype have been designed with the aid of numerical analyses. In particular, simulations of ultrasonic guided wave propagation in rails have been performed using a Local Interaction Simulation Approach (LISA) algorithm. The system's operating parameters were selected based on Receiver Operating Characteristic (ROC) curves, which provide a quantitative manner to evaluate different detection performances based on the trade-off between detection rate and false positive rate. Results from the first field test of the non-contact air-coupled defect detection prototype conducted at the Transportation Technology Center (TTC) in Pueblo, Colorado, in October 2014 are presented and discussed in this paper. The results indicate that the prototype is able to detect internal cracks with high reliability.

  5. Updating the CHAOS series of field models using Swarm data and resulting candidate models for IGRF-12

    DEFF Research Database (Denmark)

    Finlay, Chris; Olsen, Nils; Tøffner-Clausen, Lars

    Ten months of data from ESA's Swarm mission, together with recent ground observatory monthly means, are used to update the CHAOS series of geomagnetic field models with a focus on time-changes of the core field. As for previous CHAOS field models quiet-time, night-side, data selection criteria......th order spline representation with knot points spaced at 0.5 year intervals. The resulting field model is able to consistently fit data from six independent low Earth orbit satellites: Oersted, CHAMP, SAC-C and the three Swarm satellites. As an example, we present comparisons of the excellent model...

  6. Kenya's Radio Language Arts Project: evaluation results.

    Science.gov (United States)

    Oxford, R L

    1985-01-01

    The Kenya Radio Language Arts Project (RLAP), which has just been completed, documents the effectiveness of interactive radio-based educational instruction. Analyses in the areas of listening, reading, speaking, and writing show that children in radio classrooms consistently scored better than children in nonradio classrooms in every test. An evaluation of the project was conducted with the assistance of the Center for Applied Linguistics (CAL). Evaluation results came from a variety of sources, including language tests, observations, interviews, demographic and administrative records, and an attitude survey. A large proportion of the project's students were considerably transient. Only 22% of the total student population of 3908 were "normal progression" students -- that is, they advanced regularly through their education during the life of the project. Students who moved from the area, failed a standard (grade), dropped out, or were otherwise untrackable, comprised the remaining 78% of the total. 7 districts were included in the project. Tests were developed for listening and reading in Standards 1, 2, and 3 and in speaking and writing in Standards 2 and 3. The achievement tests were based on the official Kenya curriculum for those standards, so as to measure achievement against the curriculum. Nearly all the differences were highly significant statistically, with a probability of less than 1 in 1000 that the findings could have occurred by chance. Standard 1 radio students scored nearly 8 points higher than did their counterparts in the control group. Standard 2 and 3 radio students outperformed the control students by 4 points. The radio group consistently outperformed the control group in reading, writing, and speaking. Unstructured interviews and observations were conducted by the RLAP field staff. Overwhelmingly positive attitudes about the project prevailed among project teachers and headmasters. The data demonstrate that RLAP works. In fact, it works so

  7. Updating emotional content in recovered depressed individuals: Evaluating deficits in emotion processing following a depressive episode.

    Science.gov (United States)

    Levens, Sara M; Gotlib, Ian H

    2015-09-01

    Previous research has demonstrated that depressed individuals have difficulty both disengaging from negative information and maintaining positive information in working memory (WM). The present study was conducted to examine whether the tendency for depressed individuals to maintain negative content in WM and to experience difficulties maintaining positive content in WM is due to negative mood (in)congruency effects during a depressive episode, or whether these tendencies are evident outside of a depressive episode. Individuals who had recovered from a depressive episode and never disordered controls performed emotion 0-back and 2-back tasks designed to assess biases in updating emotional content in working memory. Similar to currently depressed individuals in previous studies, recovered depressed participants disengaged from happy stimuli more quickly and from sad stimuli more slowly than did their never-depressed counterparts. Despite the extension of a depression-specific finding to recovered depressed individuals, the present study does not test whether the identified emotion updating biases predict long-term relapse or recovery. The obtained results suggest that a decreased ability to disengage from negative content and to maintain positive content in WM represents a trait-like cognitive style that impairs adaptive emotion regulation and may contribute to the recurrent nature of depression. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. BC Transit Fuel Cell Bus Project Evaluation Results: Second Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Post, M.

    2014-09-01

    Second report evaluating a fuel cell electric bus (FCEB) demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. NREL published its first report on the demonstration in February 2014. This report is an update to the previous report; it covers 3 full years of revenue service data on the buses from April 2011 through March 2014 and focuses on the final experiences and lessons learned.

  9. An updated state of the science EQC model for evaluating chemical fate in the environment: application to D5 (decamethylcyclopentasiloxane).

    Science.gov (United States)

    Hughes, Lauren; Mackay, Don; Powell, David E; Kim, Jaeshin

    2012-04-01

    The EQuilibrium Criterion (EQC) model developed and published in 1996 has been widely used for screening level evaluations of the multimedia, fugacity-based environmental fate of organic chemicals for educational, industrial, and regulatory purposes. Advances in the science of chemical partitioning and reactivity and the need for more rigorous regulatory evaluations have resulted in a need to update the model. The New EQC model is described which includes an improved treatment of input partitioning and reactivity data, temperature dependence and an easier sensitivity and uncertainty analysis but uses the same multi-level approach, equations and environmental parameters as in the original version. A narrative output is also produced. The New EQC model, which uses a Microsoft Excel platform, is described and applied in detail to decamethylcyclopentasiloxane (D5; CAS No. 541-02-6). The implications of these results for the more detailed exposure and risk assessment of D5 are discussed. The need for rigorous evaluation and documentation of the input parameters is outlined. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Evaluating a new marker for risk prediction using the test tradeoff: an update.

    Science.gov (United States)

    Baker, Stuart G; Van Calster, Ben; Steyerberg, Ewout W

    2012-03-22

    Most of the methodological literature on evaluating an additional marker for risk prediction involves purely statistical measures of classification performance. A disadvantage of a purely statistical measure is the difficulty in deciding the improvement in the measure that would make inclusion of the additional marker worthwhile. In contrast, a medical decision making approach can weigh the cost or harm of ascertaining an additional marker against the benefit of a higher true positive rate for a given false positive rate that may be associated with risk prediction involving the additional marker. An appealing form of the medical decision making approach involves the risk threshold, which is the risk at which the expected utility of treatment and no treatment is the same. In this framework, a readily interpretable evaluation of the net benefit of an additional marker is the test tradeoff corresponding to the risk threshold. The test tradeoff is the minimum number of tests for a new marker that need to be traded for a true positive to yield an increase in the net benefit of risk prediction with the additional marker. For a sensitivity analysis the test tradeoff is computed over multiple risk thresholds. This article updates the theory and estimation of the test tradeoff. An example is provided.

  11. Postextubation laryngeal edema and stridor resulting in respiratory failure in critically ill adult patients : updated review

    NARCIS (Netherlands)

    Pluijms, Wouter A; van Mook, Walther Nka; Wittekamp, Bastiaan Hj; Bergmans, Dennis Cjj

    2015-01-01

    Endotracheal intubation is frequently complicated by laryngeal edema, which may present as postextubation stridor or respiratory difficulty or both. Ultimately, postextubation laryngeal edema may result in respiratory failure with subsequent reintubation. Risk factors for postextubation laryngeal

  12. Ultrasound Risk Categories for Thyroid Nodules and Cytology Results: A Single Institution’s Experience after the Adoption of the 2016 Update of Medical Guidelines by the American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi

    OpenAIRE

    Roberto Negro; Gabriele Greco; Ermenegildo Colosimo

    2017-01-01

    Objectives. In 2016, the American Association of Clinical Endocrinologists (AACE) and Associazione Medici Endocrinologi (AME) released updated guidelines for the diagnosis and management of thyroid nodules. The aim of this study was to evaluate the AACE/AME recommendations for FNA in clinical practice, by comparing the (US) stratification risk and indications for FNA with cytologic results. Methods. From May to December 2016, we collected the cytologic results from FNAs of nodules that were c...

  13. Interim Report on Heuristics about Inspection Parameters: Updates to Heuristics Resulting from Refinement on Projects

    Science.gov (United States)

    Shull, Forrest; Seaman, Carolyn; Feldman, Raimund; Haingaertner, Ralf; Regardie, Myrna

    2008-01-01

    In 2008, we have continued analyzing the inspection data in an effort to better understand the applicability and effect of the inspection heuristics on inspection outcomes. Our research goals during this period are: 1. Investigate the effect of anomalies in the dataset (e.g. the very large meeting length values for some inspections) on our results 2. Investigate the effect of the heuristics on other inspection outcome variables (e.g. effort) 3. Investigate whether the recommended ranges can be modified to give inspection planners more flexibility without sacrificing effectiveness 4. Investigate possible refinements or modifications to the heuristics for specific subdomains (partitioned, e.g., by size, domain, or Center) This memo reports our results to date towards addressing these goals. In the next section, the first goal is addressed by describing the types of anomalies we have found in our dataset, how we have addressed them, and the effect of these changes on our previously reported results. In the following section, on "methodology", we describe the analyses we have conducted to address the other three goals and the results of these analyses are described in the "results" section. Finally, we conclude with future plans for continuing our investigation.

  14. Updating Finite Element Model of a Wind Turbine Blade Section Using Experimental Modal Analysis Results

    DEFF Research Database (Denmark)

    Luczak, Marcin; Manzato, Simone; Peeters, Bart

    2014-01-01

    is to validate finite element model of the modified wind turbine blade section mounted in the flexible support structure accordingly to the experimental results. Bend-twist coupling was implemented by adding angled unidirectional layers on the suction and pressure side of the blade. Dynamic test and simulations...... were performed on a section of a full scale wind turbine blade provided by Vestas Wind Systems A/S. The numerical results are compared to the experimental measurements and the discrepancies are assessed by natural frequency difference and modal assurance criterion. Based on sensitivity analysis, set...

  15. Population Development of Baltic Bird Species: Great Cormorant (Phalacrocorax carbo sinensis) - Update with results from 2011

    DEFF Research Database (Denmark)

    Herrmann, Christof; Bregnballe, Thomas; Larsson, Kjell

    2011-01-01

    pairs (bp) only, of which Germany and Poland hosted more than the half. During the following two decades, the population development apparently has also been affected by the harmful effects of DDT and PCB. As a result of protection measures, and seemingly also due to the ban of DDT and PCB, breeding...

  16. EPA Updates Flint Response Website with Interactive Map, Chlorine Sampling Results

    Science.gov (United States)

    FLINT, MICH. -- The U.S. Environmental Protection Agency is releasing preliminary water quality data about chlorine levels in Flint's drinking water, as well as an interactive map of sampling results in Flint. The map includes data from initial chlorine te

  17. Polio vaccines, SV40 and human tumours, an update on false positive and false negative results.

    Science.gov (United States)

    Elmishad, A G; Bocchetta, M; Pass, H I; Carbone, M

    2006-01-01

    Simian virus 40 (SV40) has been detected in different human tumours in numerous laboratories. The detection of SV40 in human tumours has been linked to the administration of SV40-contaminated polio vaccines from 1954 until 1963. Many of these reports linked SV40 to human mesothelioma. Some studies have failed to detect SV40 in human tumours and this has caused a controversy. Here we review the current literature. Moreover, we present evidence showing how differences in the sensitivities of methodologies can lead to a very different interpretation of the same study. The same 20 mesothelioma specimens all tested negative, 2/20 tested positive or 7/20 tested positive for SV40 Tag by simply changing the detection method on the same immuno-precipitation/western blot membranes. These results provide a simple explanation for some of the apparent discordant results reported in the literature.

  18. PubRunner: A light-weight framework for updating text mining results.

    Science.gov (United States)

    Anekalla, Kishore R; Courneya, J P; Fiorini, Nicolas; Lever, Jake; Muchow, Michael; Busby, Ben

    2017-01-01

    Biomedical text mining promises to assist biologists in quickly navigating the combined knowledge in their domain. This would allow improved understanding of the complex interactions within biological systems and faster hypothesis generation. New biomedical research articles are published daily and text mining tools are only as good as the corpus from which they work. Many text mining tools are underused because their results are static and do not reflect the constantly expanding knowledge in the field. In order for biomedical text mining to become an indispensable tool used by researchers, this problem must be addressed. To this end, we present PubRunner, a framework for regularly running text mining tools on the latest publications. PubRunner is lightweight, simple to use, and can be integrated with an existing text mining tool. The workflow involves downloading the latest abstracts from PubMed, executing a user-defined tool, pushing the resulting data to a public FTP or Zenodo dataset, and publicizing the location of these results on the public PubRunner website. We illustrate the use of this tool by re-running the commonly used word2vec tool on the latest PubMed abstracts to generate up-to-date word vector representations for the biomedical domain. This shows a proof of concept that we hope will encourage text mining developers to build tools that truly will aid biologists in exploring the latest publications.

  19. The DEAP-3600 dark matter search experiment. Updates and commissioning results

    Energy Technology Data Exchange (ETDEWEB)

    Pollmann, Tina [Laurentian University, Sudbury (Canada)

    2016-07-01

    The DEAP-3600 experiment uses a 3.6 tonne liquid argon target for a direct dark matter search with a projected sensitivity to the spin-independent WIMP-nucleon cross-section of 10{sup -46} cm{sup 2} at 100 GeV WIMP mass after a three-year background-free exposure. DEAP is operated as a single-phase detector. The liquid argon volume is viewed by 255 high efficiency photo multiplier tubes, which record the scintillation light emitted when particles interact there. The resulting pulse shapes allow very efficient rejection of the overwhelming electromagnetic backgrounds from the dark matter signal region using pulse shape discrimination. To meet the detector's extremely stringent background targets, remaining backgrounds are suppressed through several layers of active and passive shielding - including 6000 m.w.e of rock overburden, through material screening, through the use of clean construction techniques, through careful detector design, and in offline analysis through fiducialization. The DEAP detector was built between the years of 2011 and 2016 at the SNOLAB facility, 2 km underground, and is currently taking commissioning data. We present the status of the experiment and results from analysis of the first commissioning data on behalf of the DEAP-3600 collaboration.

  20. Decay data evaluation project (DDEP): Updated evaluations of the {sup 233}Th and {sup 241}Am decay characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Chechev, Valery P., E-mail: chechev@khlopin.r [V.G. Khlopin Radium Institute, 28 Second Murinsky Ave., St. Petersburg 194021 (Russian Federation); Kuzmenko, Nikolay K. [V.G. Khlopin Radium Institute, 28 Second Murinsky Ave., St. Petersburg 194021 (Russian Federation)

    2010-07-15

    The results of new decay data evaluations are presented for {sup 233}Th ({beta}{sup -}) decay to nuclear levels in {sup 233}Pa and {sup 241}Am ({alpha}) decay to nuclear levels in {sup 237}Np. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2009.

  1. Global Positioning System receiver evaluation results

    Energy Technology Data Exchange (ETDEWEB)

    Byrne, R.H.

    1993-09-01

    A Sandia project currently uses an outdated Magnavox 6400 Global Positioning System (GPS) receiver as the core of its navigation system. The goal of this study was to analyze the performance of the current GPS receiver compared to newer, less expensive models and to make recommendations on how to improve the performance of the overall navigation system. This paper discusses the test methodology used to experimentally analyze the performance of different GPS receivers, the test results, and recommendations on how an upgrade should proceed. Appendices contain detailed information regarding the raw data, test hardware, and test software.

  2. Innovation in abutment-free bone-anchored hearing devices in children: Updated results and experience.

    Science.gov (United States)

    Baker, Shaun; Centric, Aaron; Chennupati, Sri Kiran

    2015-10-01

    Bone-anchored hearing devices are an accepted treatment option for hearing restoration in various types of hearing loss. Traditional devices have a percutaneous abutment for attachment of the sound processor that contributes to a high complication rate. Previously, our institution reported on the Sophono (Boulder, CO, USA) abutment-free system that produced similar audiologic results to devices with abutments. Recently, Cochlear Americas (Centennial, CO, USA) released an abutment-free bone-anchored hearing device, the BAHA Attract. In contrast to the Sophono implant, the BAHA Attract utilizes an osseointegrated implant. This study aims to demonstrate patient benefit abutment-free devices, compare the results of the two abutment-free devices, and examine complication rates. A retrospective chart review was conducted for the first eleven Sophono implanted patients and for the first six patients implanted with the BAHA Attract at our institution. Subsequently, we analyzed patient demographics, audiometric data, clinical course and outcomes. Average improvement for the BAHA Attract in pure-tone average (PTA) and speech reception threshold (SRT) was 41dB hearing level (dBHL) and 56dBHL, respectively. Considering all frequencies, the BAHA Attract mean improvement was 39dBHL (range 32-45dBHL). The Sophono average improvement in PTA and SRT was 38dBHL and 39dBHL, respectively. The mean improvement with Sophono for all frequencies was 34dBHL (range 24-43dBHL). Significant improvements in both pure-tone averages and speech reception threshold for both devices were achieved. In direct comparison of the two separate devices using the chi-square test, the PTA and SRT data between the two devices do not show a statistically significant difference (p-value 0.68 and 0.56, respectively). The complication rate for these abutment-free devices is lower than that of those featuring the transcutaneous abutment, although more studies are needed to further assess this potential advantage

  3. [Prophylactic laser treatment to macular soft drusen in age-related maculopathy of updated results].

    Science.gov (United States)

    Huang, Ying-xiang; Xiang, Li-nan; Wang, Yan-ling; Gao, Li-xin; Hu, Yong-xia

    2008-11-01

    To investigate the follow-up results of the prophylactic laser treatment to macular soft drusen in age-related macular degeneration. Prospective, 10 persons with bilateral soft drusen and with good visual acuity were observed for 8 years. 10 eyes were treated. The fellow eyes were as control group. Fluorescein angiography and Amsler test were studied after 8 years. Scanning laser ophthalmoscope was performed after 2 years. Some of them were performed multifocal ERG to test the macular function after 3 years. There is no choroidal neovascularization in both the laser group and the control group. There is no differences in the best corrected visual acuity after 8 years. All eyes had good fovea fixation. Light sensitivity of both eyes had no significant difference to be found by scanning laser ophthalmoscope. The latencies and amplitude densities of the N1 and P1 waves in the central first ring remained unchanged at 3 years post-treatment (before treatment t = -0.779, 0.722, -0.491, 0.286; after treatment t = 1.342, 0.043, 0.937, 0.350; P > 0.05) compared with the fellow eyes. There is no impairment to be found in the macula after preventive laser treatment. The treatment did not demonstrate a clinically significant benefit for choroidal neovascularization in eyes of people with bilateral large drusen.

  4. Evaluating propagation method performance over time with Bayesian updating: an application to incubator testing

    Science.gov (United States)

    Converse, Sarah J.; Chandler, J. N.; Olsen, G.H.; Shafer, C. C.; Hartup, Barry K.; Urbanek, Richard P.

    2010-01-01

    In captive-rearing programs, small sample sizes can limit the quality of information on performance of propagation methods. Bayesian updating can be used to increase information on method performance over time. We demonstrate an application to incubator testing at USGS Patuxent Wildlife Research Center. A new type of incubator was purchased for use in the whooping crane (Grus americana) propagation program, which produces birds for release. We tested the new incubator for reliability, using sandhill crane (Grus canadensis) eggs as surrogates. We determined that the new incubator should result in hatching rates no more than 5% lower than the available incubators, with 95% confidence, before it would be used to incubate whooping crane eggs. In 2007, 5 healthy chicks hatched from 12 eggs in the new incubator, and 2 hatched from 5 in an available incubator, for a median posterior difference of method, where a veterinarian determined whether eggs produced chicks that, at hatching, had no apparent health problems that would impede future release. We used the 2007 estimates as priors in the 2008 analysis. In 2008, 7 normal chicks hatched from 15 eggs in the new incubator, and 11 hatched from 15 in an available incubator, for a median posterior difference of 19%, with 95% credible interval (-8%, 44%). The increased sample size has increased our understanding of incubator performance. While additional data will be collected, at this time the new incubator does not appear adequate for use with whooping crane eggs.

  5. Project update: evaluating the community health legacy of WWI chemical weapons testing.

    Science.gov (United States)

    Fox, Mary A

    2014-10-01

    The Spring Valley community of Washington, District of Columbia, was built on the site of a World War I chemical weapons lab where testing activities had distributed arsenic to surface soil and waste disposal had resulted in localized subsurface contamination. In previous work, findings were suggestive of potential site-related health issues, although no evidence of cancer clustering was found. In follow-up, we updated the community health assessment and explored time trends for several arsenic-related cancers. Health indicators continue to be very good in Spring Valley. For all major causes of mortality, Spring Valley rates were lower than United States (US) rates with most substantially lower (20-80 %); rates for heart diseases, Alzheimer's, and essential hypertension and related kidney disease were only slightly lower than US rates (3-8 %). Incidence and mortality rates for the selected cancers in the Spring Valley area were lower than US rates. Small non-statistically significant increasing time trends were observed in Spring Valley for incidence of two arsenic-related cancers: bladder and lung and bronchus. A moderate statistically significant increasing rate trend was observed for lung and bronchus cancer mortality in Spring Valley (p community, the local comparison area closely matched to Spring Valley on important demographic variables, suggesting that the observed increases may not be site-related. A full profile of common cancer site rates and trends for both study areas was suggested to better understand the rate trend findings but no epidemiological study was recommended.

  6. Update of identification and estimation of socioeconomic impacts resulting from perceived risks and changing images: An annotated bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Nieves, L.A.; Clark, D.E.; Wernette, D.

    1991-08-01

    This annotated bibliography reviews selected literature published through August 1991 on the identification of perceived risks and methods for estimating the economic impacts of risk perception. It updates the literature review found in Argonne National Laboratory report ANL/EAIS/TM-24 (February 1990). Included in this update are (1) a literature review of the risk perception process, of the relationship between risk perception and economic impacts, of economic methods and empirical applications, and interregional market interactions and adjustments; (2) a working bibliography (that includes the documents abstracted in the 1990 report); (3) a topical index to the abstracts found in both reports; and (4) abstracts of selected articles found in this update.

  7. Further evaluation of an updated PCR assay for the detection of Schistosoma mansoni DNA in human stool samples.

    Science.gov (United States)

    Gomes, Luciana I; Marques, Letícia H S; Enk, Martin J; Coelho, Paulo Marcos Z; Rabello, Ana

    2009-12-01

    A previously reported sensitive PCR assay for the detection of Schistosoma mansoni DNA was updated and evaluated. Changes in the DNA extraction method, including the use of a worldwide available commercial kit and the inclusion of additional quality control measures, increased the robustness of the test, as confirmed by the analysis of 67 faecal samples from an endemic area in Brazil. The PCR assay is at hand as a proven, reliable diagnostic test for the control of schistosomiasis in specific settings.

  8. Mechanisms of change in psychotherapy for depression: An empirical update and evaluation of research aimed at identifying psychological mediators.

    Science.gov (United States)

    Lemmens, Lotte H J M; Müller, Viola N L S; Arntz, Arnoud; Huibers, Marcus J H

    2016-12-01

    We present a systematic empirical update and critical evaluation of the current status of research aimed at identifying a variety of psychological mediators in various forms of psychotherapy for depression. We summarize study characteristics and results of 35 relevant studies, and discuss the extent to which these studies meet several important requirements for mechanism research. Our review indicates that in spite of increased attention for the topic, advances in theoretical consensus about necessities for mechanism research, and sophistication of study designs, research in this field is still heterogeneous and unsatisfactory in methodological respect. Probably the biggest challenge in the field is demonstrating the causal relation between change in the mediator and change in depressive symptoms. The field would benefit from a further refinement of research methods to identify processes of therapeutic change. Recommendations for future research are discussed. However, even in the most optimal research designs, explaining psychotherapeutic change remains a challenge. Psychotherapy is a multi-dimensional phenomenon that might work through interplay of multiple mechanisms at several levels. As a result, it might be too complex to be explained in relatively simple causal models of psychological change. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Economic Evaluations of Pharmacogenetic and Pharmacogenomic Screening Tests : A Systematic Review. Second Update of the Literature

    NARCIS (Netherlands)

    Berm, Elizabeth J J; Looff, Margot de; Wilffert, Bob; Boersma, Cornelis; Annemans, Lieven; Vegter, Stefan; van Boven, Job FM; Postma, Maarten J

    2016-01-01

    Objective Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. Methods A literature search was performed in PubMed and papers published between

  10. [Institutional strengthening and updating of the National Academy of Medicine of Mexico (results and instrumentalization 2010-2012)].

    Science.gov (United States)

    Ruiz de Chávez, Manuel H; Kershenobich, David; Mansilla Olivares, Armando; Mancilla Ramírez, Javier; Kuri Morales, Pablo; Del Valle Muñoz, Alejandro

    2011-01-01

    In order to strengthen the academic and social management of the National Academy of Medicine of Mexico, from the draft paper presented to run for Vice President of the corporation, in 2007 I proposed to the plenary of the institution to develop a planning exercise strategy, in fact supporting the achievement of that objective. The idea behind the proposal, which was supported by most scholars, started from the consideration that although the Academy has always been an area of excellence for the advancement of medicine in the country, it was now necessary to strengthen, modernize and give a new direction to its work, on the basis of an exercise analysis and background checks, work, commitment and vision, under a inclusive, plural and agreed strategy with the academic body of the corporation, i.e. through a designed planning exercise. The result of this surely positive effort is presented in the following pages. To this end, part of the initial project description illustrates the process of technical and methodological development, the lines of action considered as priorities by academics, and details involving its realization. This planning strategy project yielded three specific conclusions: (i) the necessity for a functional reorganization proposal of the Academy's structure; (ii) the need for a self-sustainability financial project to fortify the economic capacity of the Academy; and (iii) the need for an updated project on technological communication of the Academy.

  11. Conducting and Evaluating Stakeholder Workshops to Facilitate Updates to a Storm Surge Forecasting Model for Coastal Louisiana

    Science.gov (United States)

    DeLorme, D.; Lea, K.; Hagen, S. C.

    2016-12-01

    As coastal Louisiana evolves morphologically, ecologically, and from engineering advancements, there is a crucial need to continually adjust real-time forecasting and coastal restoration planning models. This presentation discusses planning, conducting, and evaluating stakeholder workshops to support such an endeavor. The workshops are part of an ongoing Louisiana Sea Grant-sponsored project. The project involves updating an ADCIRC (Advanced Circulation) mesh representation of topography including levees and other flood control structures by applying previously-collected elevation data and new data acquired during the project. The workshops are designed to educate, solicit input, and ensure incorporation of topographic features into the framework is accomplished in the best interest of stakeholders. During this project's first year, three one-day workshops directed to levee managers and other local officials were convened at agricultural extension facilities in Hammond, Houma, and Lake Charles, Louisiana. The objectives were to provide a forum for participants to learn about the ADCIRC framework, understand the importance of accurate elevations for a robust surge model, discuss and identify additional data sources, and become familiar with the CERA (Coastal Emergency Risks Assessment) visualization tool. The workshop structure consisted of several scientific presentations with questions/answer time (ADCIRC simulation inputs and outputs; ADCIRC framework elevation component; description and examples of topographic features such as levees, roadways, railroads, etc. currently utilized in the mesh; ADCIRC model validation demonstration through historic event simulations; CERA demonstration), a breakout activity for participant groups to identify and discuss raised features not currently in the mesh and document them on provided worksheets, and a closing session for debriefing and discussion of future model improvements. Evaluation involved developing, and analyzing a

  12. Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results

    DEFF Research Database (Denmark)

    Jensen, Lars Juhl; Wernersson, Rasmus; Brunak, Søren

    2010-01-01

    results. In Cyclebase version 2.0, we have updated the entire database to reflect changes to genome annotations, included information on cyclin-dependent kinase (CDK) substrates, predicted degradation signals and loss-of-function phenotypes from genome-wide screens. The web interface has been improved...

  13. Results of the Updated NASA Kennedy Space Center 50-MHz Doppler Radar Wind Profiler Operational Acceptance Test

    Science.gov (United States)

    Barbre', Robert E., Jr.; Deker, Ryan K.; Leahy, Frank B.; Huddleston, Lisa

    2016-01-01

    We present here the methodology and results of the Operational Acceptance Test (OAT) performed on the new Kennedy Space Center (KSC) 50-MHz Doppler Radar Wind Profiler (DRWP). On day-of-launch (DOL), space launch vehicle operators have used data from the DRWP to invalidate winds in prelaunch loads and trajectory assessments due to the DRWP's capability to quickly identify changes in the wind profile within a rapidly-changing wind environment. The previous DRWP has been replaced with a completely new system, which needs to undergo certification testing before being accepted for use in range operations. The new DRWP replaces the previous three-beam system made of coaxial cables and a copper wire ground plane with a four-beam system that uses Yagi antennae with enhanced beam steering capability. In addition, the new system contains updated user interface software while maintaining the same general capability as the previous system. The new DRWP continues to use the Median Filter First Guess (MFFG) algorithm to generate a wind profile from Doppler spectra at each range gate. DeTect (2015) contains further details on the upgrade. The OAT is a short-term test designed so that end users can utilize the new DRWP in a similar manner to the previous DRWP during mission operations at the Eastern Range in the midst of a long-term certification process. This paper describes the Marshall Space Flight Center Natural Environments Branch's (MSFC NE's) analyses to verify the quality and accuracy of the DRWP's meteorological data output as compared to the previous DRWP. Ultimately, each launch vehicle program has the responsibility to certify the system for their own use.

  14. Further evaluation of an updated PCR assay for the detection of Schistosoma mansoni DNA in human stool samples

    Directory of Open Access Journals (Sweden)

    Luciana I Gomes

    2009-12-01

    Full Text Available A previously reported sensitive PCR assay for the detection of Schistosoma mansoni DNA was updated and evaluated. Changes in the DNA extraction method, including the use of a worldwide available commercial kit and the inclusion of additional quality control measures, increased the robustness of the test, as confirmed by the analysis of 67 faecal samples from an endemic area in Brazil. The PCR assay is at hand as a proven, reliable diagnostic test for the control of schistosomiasis in specific settings.

  15. Providing Doctors With High-Quality Information: An Updated Evaluation of Web-Based Point-of-Care Information Summaries.

    Science.gov (United States)

    Kwag, Koren Hyogene; González-Lorenzo, Marien; Banzi, Rita; Bonovas, Stefanos; Moja, Lorenzo

    2016-01-19

    The complexity of modern practice requires health professionals to be active information-seekers. Our aim was to review the quality and progress of point-of-care information summaries-Web-based medical compendia that are specifically designed to deliver pre-digested, rapidly accessible, comprehensive, and periodically updated information to health care providers. We aimed to evaluate product claims of being evidence-based. We updated our previous evaluations by searching Medline, Google, librarian association websites, and conference proceedings from August 2012 to December 2014. We included Web-based, regularly updated point-of-care information summaries with claims of being evidence-based. We extracted data on the general characteristics and content presentation of products, and we quantitatively assessed their breadth of disease coverage, editorial quality, and evidence-based methodology. We assessed potential relationships between these dimensions and compared them with our 2008 assessment. We screened 58 products; 26 met our inclusion criteria. Nearly a quarter (6/26, 23%) were newly identified in 2014. We accessed and analyzed 23 products for content presentation and quantitative dimensions. Most summaries were developed by major publishers in the United States and the United Kingdom; no products derived from low- and middle-income countries. The main target audience remained physicians, although nurses and physiotherapists were increasingly represented. Best Practice, Dynamed, and UptoDate scored the highest across all dimensions. The majority of products did not excel across all dimensions: we found only a moderate positive correlation between editorial quality and evidence-based methodology (r=.41, P=.0496). However, all dimensions improved from 2008: editorial quality (P=.01), evidence-based methodology (P=.015), and volume of diseases and medical conditions (PUptoDate scored the highest across all dimensions, while others that were marketed as evidence

  16. Review of evaluations of crushing results for the seedbed preparation

    Directory of Open Access Journals (Sweden)

    Siegfried Anisch

    2016-06-01

    Full Text Available For evaluating the work results of tillage operations today only inaccurate parameters are available which cannot be readily measured. Thus, evaluating and comparing the work results of machines and developing suitable sensors are difficult. At the Technical University of Dresden, till 1990, research projects for determining aggregate size composition of soil have been done. Based on this work, this study will show suggestions for measuring, displaying and evaluation of soil crushing results depending on tillage work conditions.

  17. Fourth update on CT angiography of coronary stents: in vitro evaluation of 24 novel stent types.

    Science.gov (United States)

    Hickethier, Tilman; Wenning, Justus; Doerner, Jonas; Maintz, David; Michels, Guido; Bunck, Alexander C

    2017-01-01

    Background Non-invasive evaluation of coronary stent patency by coronary computed tomography angiography (cCTA) remains challenging. Multiple studies showed that CT technology but also individual stent design strongly influence the assessability of coronary stents by cCTA. Purpose To expand the available data on cCTA characteristics of coronary stents by 24 novel types to help interpreting examinations of patients after stent placement and selecting which stents are suitable for assessment by cCTA. Material and Methods Twenty-four novel coronary stents (17 cobalt-chromium, six stainless-steel, one platinum-chromium) were examined in a coronary phantom. Standard cCTA parameters with stent-specific algorithms were used. Image quality was quantified for each stent using established parameters (in-stent attenuation alteration and visible lumen diameter). Results Most stents (n = 14) showed lumen visibilities of 45-55%. No severe restriction of lumen visibility (>60%) was found. The majority of stents (n = 13) caused only small intraluminal attenuation deviations and no severe alterations (>20%) were found. When grouped by manufacturing material, no significant differences were found between cobalt-chromium and stainless-steel with identical mean visible diameters (1.52 ± 0.17 mm vs. 1.52 ± 0.13 mm) and comparable attenuation alterations (35.04 ± 16.56 HU vs. 21.25 ± 14.60 HU). The only platinum-chromium stent showed a smaller visible diameter (1.23 mm) and higher attenuation alteration (41.70 HU), but was also deemed to be assessable by cCTA. Conclusion All 24 novel evaluated stents are eligible for non-invasive evaluation by cCTA without significant differences between cobalt-chromium and stainless-steel stents. This updated catalogue of CT appearances of current coronary stents may serve as reference when taking care of patients with stents in need of coronary imaging.

  18. Updated results from GEST study: a randomized, three-arm phase III study for advanced pancreatic cancer.

    Science.gov (United States)

    Okusaka, Takuji; Miyakawa, H; Fujii, H; Nakamori, S; Satoh, T; Hamamoto, Y; Ito, T; Maguchi, H; Matsumoto, S; Ueno, H; Ioka, T; Boku, N; Egawa, S; Hatori, T; Furuse, J; Mizumoto, K; Ohkawa, S; Yamaguchi, T; Yamao, K; Funakoshi, A; Chen, J S; Cheng, A L; Sato, A; Ohashi, Y; Tanaka, M

    2017-06-01

    The GEST study showed non-inferiority of S-1 but not superiority of gemcitabine plus S-1 (GS) to gemcitabine alone for overall survival with the data by the cut-off date of 31st July in 2010 for chemo-naïve patients with advanced pancreatic cancer. We considered it important to determine whether S-1 maintains non-inferiority after a long-term follow-up in the GEST study and to obtain a firm positive conclusion. In addition, it may be an interesting challenge to explore the efficacious profile of GS in the long-term follow-up study. Using the data from the follow-up period, background and efficacy in patients from Taiwan and Japan, as well as the rates of tumor shrinkage in locally advanced and metastatic patients (Waterfall plot) were also analyzed. The results of the primary analysis were reconfirmed, and subset analysis of overall survival and progression-free survival was performed based on the overall survival data updated by the cut-off date of 31st July in 2011. The median follow-up period was 29.8 months, and 795 deaths occurred (95.6%). The median overall survival was 8.8 months for gemcitabine, 9.7 months for S-1 (hazard ratio [HR], 0.96; 97.5% confidence interval [CI], 0.79-1.17), and 9.9 months for GS (HR 0.91; 97.5% CI 0.75-1.11). In patients with performance status (PS) 0, the median overall survival was 9.8 months for gemcitabine, 10.9 months for S-1, and 10.5 months for GS. In patients with PS 1, the median overall survival was 6.2 months for gemcitabine, 6.3 months for S-1, and 9.6 months for GS. Our survey reconfirmed the non-inferiority of S-1 to gemcitabine and showed S-1 can be used as one of the standard treatment options for advanced pancreatic cancer. ClinicalTrials.gov: NCT00498225.

  19. Dynamic Model Updating Using Virtual Antiresonances

    Directory of Open Access Journals (Sweden)

    Walter D’Ambrogio

    2004-01-01

    Full Text Available This paper considers an extension of the model updating method that minimizes the antiresonance error, besides the natural frequency error. By defining virtual antiresonances, this extension allows the use of previously identified modal data. Virtual antiresonances can be evaluated from a truncated modal expansion, and do not correspond to any physical system. The method is applied to the Finite Element model updating of the GARTEUR benchmark, used within an European project on updating. Results are compared with those previously obtained by estimating actual antiresonances after computing low and high frequency residuals, and with results obtained by using the correlation (MAC between identified and analytical mode shapes.

  20. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: Second Results Report and Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2011-10-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. This is the second results report for the AT fuel cell bus since it was placed in service, and it focuses on the newest data analysis and lessons learned since the previous report. The appendices, referenced in the main report, provide the full background for the evaluation. They will be updated as new information is collected but will contain the original background material from the first report.

  1. Nuclear Decay Data for the International Reactor Dosimetry Library for Fission and Fusion (IRDFF): Updated Evaluations of the Half-Lives and Gamma Ray Intensities

    Science.gov (United States)

    Chechev, Valery P.; Kuzmenko, Nikolay K.

    2016-02-01

    Updated evaluations of the half-lives and prominent gamma ray intensities have been presented for 20 radionuclides - dosimetry reaction residuals. The new values of these decay characteristics recommended for the IRDFF library were obtained using the approaches and methodology adopted by the working group of the Decay Data Evaluation Project (DDEP) cooperation. The experimental data published up to 2014 were taken into account in updated evaluations. The list of radionuclides includes 3H, 18F, 22Na, 24Na, 46Sc, 51Cr, 54Mn, 59Fe, 57Co, 60Co, 57Ni, 64Cu, 88Y, 132Te, 131I, 140Ba, 140La, 141Ce, 182Ta, 198Au.

  2. Adjuvant Sunitinib for High-risk Renal Cell Carcinoma After Nephrectomy: Subgroup Analyses and Updated Overall Survival Results

    DEFF Research Database (Denmark)

    Motzer, Robert J; Ravaud, Alain; Patard, Jean-Jacques

    2018-01-01

    the relationship between baseline factors and DFS, pattern of recurrence, and updated overall survival (OS). DESIGN, SETTING, AND PARTICIPANTS: Data for 615 patients randomized to sunitinib (n=309) or placebo (n=306) in the S-TRAC trial. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Subgroup DFS analyses...... by baseline risk factors were conducted using a Cox proportional hazards model. Baseline risk factors included: modified University of California Los Angeles integrated staging system criteria, age, gender, Eastern Cooperative Oncology Group performance status (ECOG PS), weight, neutrophil-to-lymphocyte ratio...

  3. Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection - United States, October 2017.

    Science.gov (United States)

    Adebanjo, Tolulope; Godfred-Cato, Shana; Viens, Laura; Fischer, Marc; Staples, J Erin; Kuhnert-Tallman, Wendi; Walke, Henry; Oduyebo, Titilope; Polen, Kara; Peacock, Georgina; Meaney-Delman, Dana; Honein, Margaret A; Rasmussen, Sonja A; Moore, Cynthia A

    2017-10-20

    CDC has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection (1) in response to recently published updated guidance for health care providers caring for pregnant women with possible Zika virus exposure (2), unknown sensitivity and specificity of currently available diagnostic tests for congenital Zika virus infection, and recognition of additional clinical findings associated with congenital Zika virus infection. All infants born to mothers with possible Zika virus exposure* during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit including a comprehensive physical examination, age-appropriate vision screening and developmental monitoring and screening using validated tools (3-5), and newborn hearing screen at birth, preferably using auditory brainstem response (ABR) methodology (6). Specific guidance for laboratory testing and clinical evaluation are provided for three clinical scenarios in the setting of possible maternal Zika virus exposure: 1) infants with clinical findings consistent with congenital Zika syndrome regardless of maternal testing results, 2) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers with laboratory evidence of possible Zika virus infection, † and 3) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers without laboratory evidence of possible Zika virus infection. Infants in the first two scenarios should receive further testing and evaluation for Zika virus, whereas for the third group, further testing and clinical evaluation for Zika virus are not recommended. Health care providers should remain alert for abnormal findings (e.g., postnatal-onset microcephaly and eye abnormalities without microcephaly) in infants with possible congenital Zika virus exposure without apparent abnormalities at birth.

  4. ExoMars 2016 EDM SM Mechanical Test Campaign Engineering Results Evaluation

    Science.gov (United States)

    Luison, Dario; Tenore, Amedeo Giancarlo

    2014-06-01

    This paper describes the analytical engineering activities done in the frame of ExoMars Descent Module (EDM) Structural Model (SM) Mechanical Test Campaign performed in ESTEC (for Sinusoidal Test) and in Thales Alenia Space Turin (Italy) laboratories (for Static Test) in the period from February and July 2013.The main results of Sine and Static Tests are described, as well as the updating of the Mathematical Model based on the results of the Base Excitation Vibration Modal Parameters Extraction. The engineering test evaluation activity was concentrated in particular on the simulation of the failure occurred during the sine test. This failure represented a serious issues never encountered in previous tests. Despite the gravity of the phenomenon, in a short time, the engineering was able to prove the structural integrity and to conclude successfully the test.

  5. Non-Formal Educator Use of Evaluation Results

    Science.gov (United States)

    Baughman, Sarah; Boyd, Heather H.; Franz, Nancy K.

    2012-01-01

    Increasing demands for accountability in educational programming have resulted in increasing calls for program evaluation in educational organizations. Many organizations include conducting program evaluations as part of the job responsibilities of program staff. Cooperative Extension is a complex organization offering non-formal educational…

  6. The ASCD Healthy School Communities Project: Formative Evaluation Results

    Science.gov (United States)

    Valois, Robert F.; Lewallen, Theresa C.; Slade, Sean; Tasco, Adriane N.

    2015-01-01

    Purpose: The purpose of this paper is to report the formative evaluation results from the Association for Supervision and Curriculum Development Healthy School Communities (HSC) pilot project. Design/methodology/approach: This study utilized 11 HSC pilot sites in the USA (eight sites) and Canada (three sites). The evaluation question was…

  7. Glycemic index, glycemic load, and risk of type 2 diabetes: results from 3 large US cohorts and an updated meta-analysis123

    Science.gov (United States)

    Bhupathiraju, Shilpa N; Tobias, Deirdre K; Malik, Vasanti S; Pan, An; Hruby, Adela; Manson, JoAnn E; Willett, Walter C; Hu, Frank B

    2014-01-01

    Background: Epidemiologic evidence for the relation between carbohydrate quality and risk of type 2 diabetes (T2D) has been mixed. Objective: We prospectively examined the association of dietary glycemic index (GI) and glycemic load (GL) with T2D risk. Design: We prospectively followed 74,248 women from the Nurses’ Health Study (1984–2008), 90,411 women from the Nurses’ Health Study II (1991–2009), and 40,498 men from the Health Professionals Follow-Up Study (1986–2008) who were free of diabetes, cardiovascular disease, and cancer at baseline. Diet was assessed by using a validated questionnaire and updated every 4 y. We also conducted an updated meta-analysis, including results from our 3 cohorts and other studies. Results: During 3,800,618 person-years of follow-up, we documented 15,027 cases of incident T2D. In pooled multivariable analyses, those in the highest quintile of energy-adjusted GI had a 33% higher risk (95% CI: 26%, 41%) of T2D than those in the lowest quintile. Participants in the highest quintile of energy-adjusted GL had a 10% higher risk (95% CI: 2%, 18%) of T2D. Participants who consumed a combination diet that was high in GI or GL and low in cereal fiber had an ∼50% higher risk of T2D. In the updated meta-analysis, the summary RRs (95% CIs) comparing the highest with the lowest categories of GI and GL were 1.19 (1.14, 1.24) and 1.13 (1.08, 1.17), respectively. Conclusion: The updated analyses from our 3 cohorts and meta-analyses provide further evidence that higher dietary GI and GL are associated with increased risk of T2D. PMID:24787496

  8. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  9. Teacher Effectiveness: An Update on Pennsylvania's Teacher Evaluation System. Issue Brief

    Science.gov (United States)

    Research For Action, 2013

    2013-01-01

    Act 82 of 2012 established new standards for Pennsylvania's teacher evaluation system, including the incorporation of student performance measures in ratings decisions. Since 2009, approximately 35 states have amended teacher evaluation systems, with student achievement playing an increasingly prominent role. This count includes neighboring…

  10. Evaluation and Management of Tolosa-Hunt Syndrome in Children: A Clinical Update.

    Science.gov (United States)

    Pérez, Carlos A; Evangelista, Monaliza

    2016-09-01

    Tolosa-Hunt syndrome is a painful ophthalmoplegia caused by an inflammatory process of unknown etiology in the region of the cavernous sinus, orbital apex, or superior orbital fissure. This disease is rare in the pediatric population. The objective of this study was to provide a clinical framework for the evaluation and treatment of children with this disorder. A systematic approach to the diagnosis of painful ophthalmoplegia in children is proposed. We present a 15-year-old girl whose clinical presentation and neuroradiological findings support a diagnosis of Tolosa-Hunt syndrome as defined by the 2013 International Classification of Headache Disorders (Third Edition, ICHD-3 beta) diagnostic criteria. An exhaustive systematic literature search based on these criteria yielded 15 additional cases of Tolosa-Hunt syndrome in children. Clinical, demographic, and radiological features were retrospectively analyzed. The results and statistical analyses are reported. A total of 16 individuals were included in the final analysis. This review summarizes the current knowledge and recommendations for the diagnosis and management of pediatric Tolosa-Hunt syndrome. It highlights demographic, clinical, and radiological features of this disease in children and underscores areas of the literature where evidence is still lacking. Overall, Tolosa-Hunt syndrome seems to follow a similar course in children compared to adults. The diagnostic approach and treatment require specific considerations. New observations and possible features of pediatric Tolosa-Hunt syndrome are discussed. Further research is needed to optimize clinical detection and medical management of this disease. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Evaluating the effect of integrated microfinance and health interventions: an updated review of the evidence.

    Science.gov (United States)

    Lorenzetti, Lara M J; Leatherman, Sheila; Flax, Valerie L

    2017-06-01

    Solutions delivered within firm sectoral boundaries are inadequate in achieving income security and better health for poor populations. Integrated microfinance and health interventions leverage networks of women to promote financial inclusion, build livelihoods, and safeguard against high cost illnesses. Our understanding of the effect of integrated interventions has been limited by variability in intervention, outcome, design, and methodological rigour. This systematic review synthesises the literature through 2015 to understand the effect of integrated microfinance and health programs. We searched PubMed, Scopus, Embase, EconLit, and Global Health databases and sourced bibliographies, identifying 964 articles exclusive of duplicates. Title, abstract, and full text review yielded 35 articles. Articles evaluated the effect of intentionally integrated microfinance and health programs on client outcomes. We rated the quality of evidence for each article. Most interventions combined microfinance with health education, which demonstrated positive effects on health knowledge and behaviours, though not health status. Among programs that integrated microfinance with other health components ( i.e. health micro-insurance, linkages to health providers, and access to health products), results were generally positive but mixed due to the smaller number and quality of studies. Interventions combining multiple health components in a given study demonstrated positive effects, though it was unclear which component was driving the effect. Most articles (57%) were moderate in quality. Integrated microfinance and health education programs were effective, though longer intervention periods are necessary to measure more complex pathways to health status. The effect of microfinance combined with other health components was less clear. Stronger randomized research designs with multiple study arms are required to improve evidence and disentangle the effects of multiple component

  12. Teratogen update: evaluation of the reproductive and developmental risks of caffeine.

    Science.gov (United States)

    Christian, M S; Brent, R L

    2001-07-01

    studies describe exposures of women to caffeine during pregnancy, as well as the occurrence of congenital malformations, fetal growth retardation, small-for-date babies, miscarriages (spontaneous abortions), behavioral effects, and maternal fertility problems that presumably resulted from the caffeine consumption. A few epidemiological studies were concerned with the genetic effects of preconception exposures to caffeine. Animal studies, conducted mostly in pregnant rats and mice, were designed to produce malformations. The objectives of the present review are to summarize the findings from the various clinical and animals studies, objectively discuss the merits and/or faults inherent in the studies and establish a global reproductive risk assessment for caffeine consumption in humans during pregnancy. It should be noted that evaluation of the developmental risks of caffeine based solely on epidemiological studies is difficult because the findings are inconsistent. Even more important, is the fact that caffeine users are subject to multiple confounding factors that make analyses difficult and prevent investigators from reaching definitive conclusions. For example, the caffeine content of foods and beverages can vary considerably, which can interfere with obtaining valid interpretations from many human studies. Isolated epidemiological studies dealing with the risk of abortion, without evaluating other developmental and reproductive effects, are the most difficult to interpret, because they present special problems that are sometimes ignored in epidemiological studies. The results of animal studies are probably most helpful in solving some of the dilemmas created by the epidemiological studies. An animal study reported in 1960 first focused our attention on the potential developmental effects of caffeine. However, the exposure reported by Nishimura and Nakai ('60) was an intraperitoneal dosage of 250 mg/kg in the mouse, an extremely high dosage that would result in a blood

  13. Food group consumption in an Italian population using the updated food classification system FoodEx2: Results from the Italian Nutrition & HEalth Survey (INHES) study.

    Science.gov (United States)

    Pounis, G; Bonanni, A; Ruggiero, E; Di Castelnuovo, A; Costanzo, S; Persichillo, M; Bonaccio, M; Cerletti, C; Riccardi, G; Donati, M B; de Gaetano, G; Iacoviello, L

    2017-04-01

    Dietary habits evolve over time, being influenced by many factors and complex interactions. This work aimed at evaluating the updated information on food group consumption in Italy. A total of 8944 (4768 women and 4176 men) participants aged >18 years from all over Italy recruited in 2010-13 (Italian Nutrition & HEalth Survey, INHES) was analyzed. The recruitment was performed using computer-assisted-telephone-interviewing and one-day 24-h dietary recall retrieved from all participants. The updated, second version, of FoodEx2 food classification system was applied to extract data on food group consumption. The participation rate was 53%; 6.2% of the participants declared to follow a special diet, the most prevalent being hypo-caloric diets (55.7% of special diets). Men compared to women presented significantly higher intakes of "grains and grain-based products", "meat and meat products", "animal and vegetable fats and oils and primary derivatives" and "alcoholic beverages" (P for allfood imitates and food supplements" (P for allfood group intake among age groups, geographical regions and educational level groups were also identified (P for allfood groups and sub-groups were illustrated in different strata. The present analysis could be considered as an updated source of information for future nutrition research in Italy and in the EU. Copyright © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

  14. Investigating the Impact on Modeled Ozone Concentrations Using Meteorological Fields From WRF With and Updated Four-Dimensional Data Assimilation Approach”

    Science.gov (United States)

    The four-dimensional data assimilation (FDDA) technique in the Weather Research and Forecasting (WRF) meteorological model has recently undergone an important update from the original version. Previous evaluation results have demonstrated that the updated FDDA approach in WRF pr...

  15. [Update in Current Care guidelines. Evaluation of a suspected child sexual abuse].

    Science.gov (United States)

    Piha, Jorma; Aronen, Eeva; Joki-Erkkilä, Minna; Komulainen, Jorma; Korkman, Julia; Raipela, Jouni; Tuominen, Mia

    2013-01-01

    According to Finnish Child Welfare Law, the authorities are obligated to report suspicions of child sexual abuse immediately to the police and to social services to ensure the well being of the child. The investigating police may request assistance for forensic interviews and medical assessments from specialized units. The child's disclosure is often the most important part of the evaluation. The timing of medical examination is crucial to obtain biological trace of evidence and to document evidence of acute injury or infection. The need for crisis support must be evaluated.

  16. WP5 Evaluation: D54-D55 Evaluation Results V2 (V3)

    NARCIS (Netherlands)

    Van Rosmalen, Peter

    2011-01-01

    Van Rosmalen, P. (2010, 19 May). WP5 Evaluation: D54-D55 Evaluation Results V2 (V3). Presentation at idSpace Final Review, Heerlen, The Netherlands: Open University of the Netherlands. idSpace-project.

  17. Evaluation of the updated regional climate model RACMO2.3 : Summer snowfall impact on the Greenland Ice Sheet

    NARCIS (Netherlands)

    Noël, B.|info:eu-repo/dai/nl/370612345; Van De Berg, W. J.|info:eu-repo/dai/nl/304831611; Van Meijgaard, E.; Kuipers Munneke, P.|info:eu-repo/dai/nl/304831891; Van De Wal, R. S W|info:eu-repo/dai/nl/101899556; Van Den Broeke, M. R.|info:eu-repo/dai/nl/073765643

    2015-01-01

    We discuss Greenland Ice Sheet (GrIS) surface mass balance (SMB) differences between the updated polar version of the RACMO climate model (RACMO2.3) and the previous version (RACMO2.1). Among other revisions, the updated model includes an adjusted rainfall-to-snowfall conversion that produces

  18. Results of a Research Evaluating Quality of Computer Science Education

    Science.gov (United States)

    Záhorec, Ján; Hašková, Alena; Munk, Michal

    2012-01-01

    The paper presents the results of an international research on a comparative assessment of the current status of computer science education at the secondary level (ISCED 3A) in Slovakia, the Czech Republic, and Belgium. Evaluation was carried out based on 14 specific factors gauging the students' point of view. The authors present qualitative…

  19. Updated Results and Patterns of Failure in a Randomized Hypofractionation Trial for High-risk Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Arcangeli, Stefano [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy); Strigari, Lidia [Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome (Italy); Gomellini, Sara; Saracino, Biancamaria; Petrongari, Maria Grazia; Pinnaro, Paola; Pinzi, Valentina [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy); Arcangeli, Giorgio, E-mail: arcangeli.gio@tiscali.it [Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome (Italy)

    2012-12-01

    patients with an iPSA level of 20 ng/mL or less. The {alpha}/{beta} ratio might be more appropriately evaluated by FFLF than FFBF results, at least in high-risk disease.

  20. Update on the U.S. Nuclear Structure and Decay Data Evaluation Program*

    Science.gov (United States)

    Baglin, Coral M.

    2000-04-01

    The U.S. Nuclear Data Program (USNDP) maintains and provides easy access to several large databases to assist scientists to sift through and assess the vast quantity of published nuclear structure and decay data. The Evaluated Nuclear Structure Data File (ENSDF) presents evaluated experimental nuclear data; the Nuclear Structure Reference (NSR) database provides bibliographic information; an Experimental Unevaluated Data Listing (XUNDL)has also recently been established to provide rapid access to data from the most recent publications (primarily in high-spin physics). In addition to the ongoing revision of data in ENSDF, information from the latest evaluations for A=21-44 by Endt[1] and evaluated data for recently-discovered heavy elements (up to Z=118) are currently being incorporated into ENSDF. An overview of nuclear structure and decay data available through the USNDP will be presented, with emphasis on recent and forthcoming additions to the material available. Feedback concerning the extent to which users' nuclear structure and decay data needs are being met by this data program will be welcomed. 1. P.M. Endt, Nucl. Phys. A521, 1 (1998). *On behalf of the U.S. Nuclear Data Program

  1. Evaluation of the Radar Stage Sensor manufactured by Forest Technology Systems—Results of laboratory and field testing

    Science.gov (United States)

    Kunkle, Gerald A.

    2018-01-31

    Two identical Radar Stage Sensors from Forest Technology Systems were evaluated to determine if they are suitable for U.S. Geological Survey (USGS) hydrologic data collection. The sensors were evaluated in laboratory conditions to evaluate the distance accuracy of the sensor over the manufacturer’s specified operating temperatures and distance to water ranges. Laboratory results were compared to the manufacturer’s accuracy specification of ±0.007 foot (ft) and the USGS Office of Surface Water (OSW) policy requirement that water-level sensors have a measurement uncertainty of no more than 0.01 ft or 0.20 percent of the indicated reading. Both of the sensors tested were within the OSW policy requirement in both laboratory tests and within the manufacturer’s specification in the distance to water test over tested distances from 3 to 15 ft. In the temperature chamber test, both sensors were within the manufacturer’s specification for more than 90 percent of the data points collected over a temperature range of –40 to +60 degrees Celsius at a fixed distance of 8 ft. One sensor was subjected to an SDI-12 communication test, which it passed. A field test was conducted on one sensor at a USGS field site near Landon, Mississippi, from February 5 to March 29, 2016. Water-level measurements made by the radar during the field test were in agreement with those made by the Sutron Accubar Constant Flow Bubble Gauge.Upon the manufacturer’s release of updated firmware version 1.09, additional SDI-12 and temperature testing was performed to evaluate added SDI-12 functions and verify that performance was unaffected by the update. At this time, an Axiom data logger is required to perform a firmware update on this sensor. The data confirmed the results of the original test. Based on the test results, the Radar Stage Sensor is a suitable choice for USGS hydrologic data collection.

  2. Ejaculation Frequency and Risk of Prostate Cancer: Updated Results with an Additional Decade of Follow-up

    Science.gov (United States)

    Rider, Jennifer R.; Wilson, Kathryn M.; Sinnott, Jennifer A.; Kelly, Rachel S.; Mucci, Lorelei A.; Giovannucci, Edward L.

    2016-01-01

    Background Evidence suggests that ejaculation frequency may be inversely related to the risk of prostate cancer (PCa), a disease for which few modifiable risk factors have been identified. Objective To incorporate an additional 10 yr of follow-up into an original analysis and to comprehensively evaluate the association between ejaculation frequency and PCa, accounting for screening, clinically relevant disease subgroups, and the impact of mortality from other causes. Design, setting, and participants A prospective cohort study of participants in the Health Professionals Follow-up Study utilizing self-reported data on average monthly ejaculation frequency. The study includes 31 925 men who answered questions on ejaculation frequency on a 1992 questionnaire and followed through to 2010. The average monthly ejaculation frequency was assessed at three time points: age 20–29 yr, age 40–49 yr, and the year before questionnaire distribution. Outcome measurements and statistical analysis Incidence of total PCa and clinically relevant disease subgroups. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results and limitations During 480 831 person-years, 3839 men were diagnosed with PCa. Ejaculation frequency at age 40–49 yr was positively associated with age-standardized body mass index, physical activity, divorce, history of sexually transmitted infections, and consumption of total calories and alcohol. Prostate-specific antigen (PSA) test utilization by 2008, number of PSA tests, and frequency of prostate biopsy were similar across frequency categories. In multivariable analyses, the hazard ratio for PCa incidence for ≥21 compared to 4–7 ejaculations per month was 0.81 (95% confidence interval [CI] 0.72–0.92; p frequency at age 20–29 yr and 0.78 (95% CI 0.69–0.89; p frequency at age 40–49 yr. Associations were driven by low-risk disease, were similar when restricted to a PSA-screened cohort, and were unlikely to be

  3. A Critical Evaluation of the Updated Evidence for Casting for Equinus Deformity in Children with Cerebral Palsy.

    Science.gov (United States)

    Tustin, Kylee; Patel, Anita

    2017-01-01

    Equinus deformity is common in ambulant children with cerebral palsy (CP). Although lower leg casting is frequently used, the physiological basis for casting and effects beyond range of motion (ROM) gains are unclear. This review critically evaluates the updated evidence for casting in the management of ankle equinus in children with CP. Comprehensive searches were conducted using electronic databases AMED, MEDLINE, CINAHL, Scopus, PEDro and the Cochrane Database of Systematic Reviews, publication years 2005-2014, in order to identify literature published since an earlier comprehensive systematic review. Only studies evaluating lower leg casting for conservative management of equinus deformity in children with CP were considered. Two independent raters critically appraised studies against the hierarchy of levels of evidence and rigour of study conduct questions proposed by the American Academy of Cerebral Palsy and Developmental Medicine's methodology for systematic review. Four relevant systematic reviews were identified, although these largely concerned earlier literature. Five original studies were included, all demonstrating improvement in dorsiflexion ROM. Combined treatment with botulinum toxin and casting offered greater and/or more sustained ROM gains than botulinum toxin alone in three studies. Effects on gait parameters and motor function were inconsistent. Participation outcomes were not evaluated. Methodological limitations make firm conclusions difficult. Recent years have offered little progress in the state of evidence for casting in the management of equinus deformity. Casting appears to offer at least short-term improvement in ankle dorsiflexion, although the proposition that this improves function or avoids surgery is not well substantiated. Future research needs to ensure more robust study design and broader evaluation across domains of the International Classification of Functioning, Disability and Health to determine the functional and long

  4. [Evaluation and results of ablative therapies in prostate cancer].

    Science.gov (United States)

    Renard-Penna, R; Sanchez-Salas, R; Barret, E; Cosset, J M; de Vergie, S; Sapetti, J; Ingels, A; Gangi, A; Lang, H; Cathelineau, X

    2017-11-01

    To perform a state of the art about methods of evaluation and present results in ablative therapies for localized prostate cancer. A review of the scientific literature was performed in Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of keywords. Publications obtained were selected based on methodology, language and relevance. After selection, 102 articles were analysed. Analyse the results of ablative therapies is presently difficult considering the heterogeneity of indications, techniques and follow-up. However, results from the most recent and homogeneous studies are encouraging. Oncologically, postoperative biopsies (the most important criteria) are negative (without any tumor cells in the treated area) in 75 to 95%. Functionally, urinary and sexual pre-operative status is spared (or recovered early) in more than 90% of the patients treated. More and more studies underline also the correlation between the results and the technique used considering the volume of the gland and, moreover, the "index lesion" localization. The post-treatment pathological evaluation by biopsies (targeted with MRI or, perhaps in a near future, with innovative ultrasonography) is the corner stone of oncological evaluation of ablative therapies. Ongoing trials will allow to standardize the follow-up and determine the best indication and the best techniques in order to optimize oncological and functional results for each patient treated. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. Updating Nutritional Data and Evaluation of Technological Parameters of Italian Milk

    Directory of Open Access Journals (Sweden)

    Pamela Manzi

    2013-06-01

    Full Text Available Different technologically treated Italian milks (whole and semi-skimmed ultra-high temperature (UHT, pasteurized and microfiltered milk, collected from 2009 to 2012, were evaluated for nutritional and technological properties. No significant differences in calcium and sodium were detected (p > 0.05, while significant differences were observed concerning phosphorus content, between whole and semi-skimmed milk, and lactose content, between pasteurized and UHT milk (p 0.05 were detected for choline, a functional molecule, between whole (11.3–14.6 mg/100 g and semi-skimmed milk (11.1–14.7 mg/100 g, but there were significant differences (p < 0.05 in processing milk (UHT vs. pasteurized milk and UHT vs. microfiltered milk. Among the unsaponifiable compounds, only 13 cis retinol and trans retinol showed differences in technologically treated milk (pasteurized vs. UHT milk and microfiltered vs. UHT milk; p < 0.05. In this research, the greater was the “severity” of milk treatment, the higher was the percent ratio 13 cis/trans retinol (DRI, degree of retinol isomerization. The degree of antioxidant protection parameter (DAP, useful to estimate the potential oxidative stability of fat in foods, was significantly different between whole and semi-skimmed milk (p < 0.05. Finally, the evaluation of color measurement of whole milk showed a good correlation between beta carotene and b* (r = 0.854 and between lactulose and a* (r = 0.862.

  6. Combining Results From Multiple Evaluations of the Same Measurand.

    Science.gov (United States)

    Kessel, Rüdiger; Kacker, Raghu N; Sommer, Klaus-Dieter

    2011-01-01

    According to the Guide to the Expression of Uncertainty in Measurement (GUM), a result of measurement consists of a measured value together with its associated standard uncertainty. The measured value and the standard uncertainty are interpreted as the expected value and the standard deviation of a state-of-knowledge probability distribution attributed to the measurand. We discuss the term metrological compatibility introduced by the International Vocabulary of Metrology, third edition (VIM3) for lack of significant differences between two or more results of measurement for the same measurand. Sometimes a combined result of measurement from multiple evaluations of the same measurand is needed. We propose an approach for determining a combined result which is metrologically compatible with the contributing results.

  7. Travinfor Evaluation: Value Added Reseller (var) Study Phase 1 Results

    OpenAIRE

    Loukakos, D.; Hall, R.; Weissenberger, S.; Yim, Y. B.

    1996-01-01

    TravInfo is a Field Operational Test (FOT) in advanced traveler information systems (ATIS) for the San Francisco Bay Area sponsored by the Federal Highway Administration (FHWA). The project involves a public/private partnership which seeks to compile, integrate and broadly disseminate timely and accurate multi-modal traveler information through commercial products and services. This working paper is part of the Technology Element of the TravInfo evaluation. It presents the results of the "bef...

  8. Nuclear Decay Data for the International Reactor Dosimetry Library for Fission and Fusion (IRDFF: Updated Evaluations of the Half-Lives and Gamma Ray Intensities

    Directory of Open Access Journals (Sweden)

    Chechev Valery P.

    2016-01-01

    Full Text Available Updated evaluations of the half-lives and prominent gamma ray intensities have been presented for 20 radionuclides – dosimetry reaction residuals. The new values of these decay characteristics recommended for the IRDFF library were obtained using the approaches and methodology adopted by the working group of the Decay Data Evaluation Project (DDEP cooperation. The experimental data published up to 2014 were taken into account in updated evaluations. The list of radionuclides includes 3H, 18F, 22Na, 24Na, 46Sc, 51Cr, 54Mn, 59Fe, 57Co, 60Co, 57Ni, 64Cu, 88Y, 132Te, 131I, 140Ba, 140La, 141Ce, 182Ta, 198Au.

  9. Updating Nutritional Data and Evaluation of Technological Parameters of Italian Milk.

    Science.gov (United States)

    Manzi, Pamela; Di Costanzo, Maria Gabriella; Mattera, Maria

    2013-06-20

    Different technologically treated Italian milks (whole and semi-skimmed ultra-high temperature (UHT), pasteurized and microfiltered milk), collected from 2009 to 2012, were evaluated for nutritional and technological properties. No significant differences in calcium and sodium were detected ( p > 0.05), while significant differences were observed concerning phosphorus content, between whole and semi-skimmed milk, and lactose content, between pasteurized and UHT milk ( p UHT milk, lactose isomerization occurred, and lactulose (from 8.6 to 104.0 mg/100 g) was detected. No significant differences ( p > 0.05) were detected for choline, a functional molecule, between whole (11.3-14.6 mg/100 g) and semi-skimmed milk (11.1-14.7 mg/100 g), but there were significant differences ( p milk (UHT vs. pasteurized milk and UHT vs. microfiltered milk). Among the unsaponifiable compounds, only 13 cis retinol and trans retinol showed differences in technologically treated milk (pasteurized vs. UHT milk and microfiltered vs. UHT milk; p milk treatment, the higher was the percent ratio 13 cis / trans retinol (DRI, degree of retinol isomerization). The degree of antioxidant protection parameter (DAP), useful to estimate the potential oxidative stability of fat in foods, was significantly different between whole and semi-skimmed milk ( p milk showed a good correlation between beta carotene and b * ( r = 0.854) and between lactulose and a * ( r = 0.862).

  10. Update and evaluation of decay data for spent nuclear fuel analyses

    Science.gov (United States)

    Simeonov, Teodosi; Wemple, Charles

    2017-09-01

    Studsvik's approach to spent nuclear fuel analyses combines isotopic concentrations and multi-group cross-sections, calculated by the CASMO5 or HELIOS2 lattice transport codes, with core irradiation history data from the SIMULATE5 reactor core simulator and tabulated isotopic decay data. These data sources are used and processed by the code SNF to predict spent nuclear fuel characteristics. Recent advances in the generation procedure for the SNF decay data are presented. The SNF decay data includes basic data, such as decay constants, atomic masses and nuclide transmutation chains; radiation emission spectra for photons from radioactive decay, alpha-n reactions, bremsstrahlung, and spontaneous fission, electrons and alpha particles from radioactive decay, and neutrons from radioactive decay, spontaneous fission, and alpha-n reactions; decay heat production; and electro-atomic interaction data for bremsstrahlung production. These data are compiled from fundamental (ENDF, ENSDF, TENDL) and processed (ESTAR) sources for nearly 3700 nuclides. A rigorous evaluation procedure of internal consistency checks and comparisons to measurements and benchmarks, and code-to-code verifications is performed at the individual isotope level and using integral characteristics on a fuel assembly level (e.g., decay heat, radioactivity, neutron and gamma sources). Significant challenges are presented by the scope and complexity of the data processing, a dearth of relevant detailed measurements, and reliance on theoretical models for some data.

  11. Update and evaluation of decay data for spent nuclear fuel analyses

    Directory of Open Access Journals (Sweden)

    Simeonov Teodosi

    2017-01-01

    Full Text Available Studsvik’s approach to spent nuclear fuel analyses combines isotopic concentrations and multi-group cross-sections, calculated by the CASMO5 or HELIOS2 lattice transport codes, with core irradiation history data from the SIMULATE5 reactor core simulator and tabulated isotopic decay data. These data sources are used and processed by the code SNF to predict spent nuclear fuel characteristics. Recent advances in the generation procedure for the SNF decay data are presented. The SNF decay data includes basic data, such as decay constants, atomic masses and nuclide transmutation chains; radiation emission spectra for photons from radioactive decay, alpha-n reactions, bremsstrahlung, and spontaneous fission, electrons and alpha particles from radioactive decay, and neutrons from radioactive decay, spontaneous fission, and alpha-n reactions; decay heat production; and electro-atomic interaction data for bremsstrahlung production. These data are compiled from fundamental (ENDF, ENSDF, TENDL and processed (ESTAR sources for nearly 3700 nuclides. A rigorous evaluation procedure of internal consistency checks and comparisons to measurements and benchmarks, and code-to-code verifications is performed at the individual isotope level and using integral characteristics on a fuel assembly level (e.g., decay heat, radioactivity, neutron and gamma sources. Significant challenges are presented by the scope and complexity of the data processing, a dearth of relevant detailed measurements, and reliance on theoretical models for some data.

  12. Evaluation of the results of coal jigging process

    Directory of Open Access Journals (Sweden)

    Surowiak Agnieszka

    2017-01-01

    Full Text Available Quality of applied hard coal fuel to combustion processes influence significantly on process efficiency and effects of its influence on surrounding environment. It is particularly important issue in time of Clean Coal Technologies (CTW. The paper presents the analysis of hard coal beneficiation in a jig for getting an optimal recovery of useful fraction in concentrate (combustible matter and not useful fraction (ash and sulfur. On the basis of industrial sampling of coal dust jig the density analysis of collected samples of concentrate and tailings was performed in laboratory conditions. In separated fractions of separation products the yields of products were calculated and the contents of ash and total sulfur were marked in them. On the basis of the results of density and chemical analyzes, separation products balance and appropriate calculations the Fuerstenau beneficiation curves were plotted which allowed to evaluate process and compare results of beneficiation of material containing various components. This is a different approach to evaluation of coal beneficiation effects, so far being used mainly for multi-component metals ores. Furthermore, the evaluation of separation preciseness on the basis of separation curves and factors was done and the statistical analysis of mutual correlations of analyzed parameters was done.

  13. Evaluation of major polluting accidents in China-Results and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Hou Yu, E-mail: houyu@dufe.edu.cn [Dongbei University of Finance and Economics, 116025 Dalian, Liaoning (China); Department of Environmental Science and Engineering, Tsinghua University, 100084 Beijing (China); Zhang Tianzhu [Dongbei University of Finance and Economics, 116025 Dalian, Liaoning (China); Department of Environmental Science and Engineering, Tsinghua University, 100084 Beijing (China)

    2009-09-15

    Lessons learnt from accidents are essential sources for updating state-of-the-art requirements in pollution accident prevention. To improve this input in the People's Republic of China in a systematic way, a database for collecting and evaluating major pollution accidents is being established. This is being done in co-operation with Chinese Society for Environment Sciences and other national Institutions. At the time of writing over 80 major events from 2002-2006 have been collected. In this paper, a summary evaluation on the major polluting events in China from 2002 to 2006 is presented and some basic lessons drawn shown. There is no a systematic pollution accident notification system currently in China. The results from root cause analysis underline the importance of emergency measures, maintenance, human factor issues and the role of safety organization. Chronic pollution, especially water pollution and air pollution should be paid the same attention as the sudden pollution. It is important to keep in mind that collecting information from major accidents represents a small percentage of the actual number of events taking place.

  14. Physical activity across the curriculum: year one process evaluation results

    Directory of Open Access Journals (Sweden)

    Sullivan Debra K

    2008-07-01

    Full Text Available Abstract Background Physical Activity Across the Curriculum (PAAC is a 3-year elementary school-based intervention to determine if increased amounts of moderate intensity physical activity performed in the classroom will diminish gains in body mass index (BMI. It is a cluster-randomized, controlled trial, involving 4905 children (2505 intervention, 2400 control. Methods We collected both qualitative and quantitative process evaluation data from 24 schools (14 intervention and 10 control, which included tracking teacher training issues, challenges and barriers to effective implementation of PAAC lessons, initial and continual use of program specified activities, and potential competing factors, which might contaminate or lessen program effects. Results Overall teacher attendance at training sessions showed exceptional reach. Teachers incorporated active lessons on most days, resulting in significantly greater student physical activity levels compared to controls (p Conclusion In the first year of the PAAC intervention, process evaluation results were instrumental in identifying successes and challenges faced by teachers when trying to modify existing academic lessons to incorporate physical activity.

  15. Economic consequences of improved temperature forecasts: An experiment with the Florida citrus growers (an update of control group results)

    Science.gov (United States)

    Braen, C.

    1978-01-01

    The economic experiment, the results obtained to date and the work which still remains to be done are summarized. Specifically, the experiment design is described in detail as are the developed data collection methodology and procedures, sampling plan, data reduction techniques, cost and loss models, establishment of frost severity measures, data obtained from citrus growers, National Weather Service and Federal Crop Insurance Corp. Resulting protection costs and crop losses for the control group sample, extrapolation of results of control group to the Florida citrus industry and the method for normalization of these results to a normal or average frost season so that results may be compared with anticipated similar results from test group measurements are discussed.

  16. Updated international clinical recommendations on scar management: part 1--evaluating the evidence.

    Science.gov (United States)

    Gold, Michael H; Berman, Brian; Clementoni, Matteo Tretti; Gauglitz, Gerd G; Nahai, Foad; Murcia, Crystal

    2014-08-01

    There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice. To review available data on methods for preventing and treating cutaneous scarring. Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management. One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment. Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.

  17. [Evaluation of the results of lumbar sympathectomy using hemodynamic variables].

    Science.gov (United States)

    Ley Pozo, J; Vega Gómez, M E; Ochoa Bizet, M; Cardona Alvarez, M; Romero Valdés, A; Fernández Boloña, A; Gutiérrez Jiménez, O

    1990-01-01

    In order to evaluate the results of the lumbar sympathectomy, we studied 49 patients in the National Institute of Angiology and Vascular Surgery during two years. The hemodynamic tests were performed the day before and one month after the surgical intervention; they included: skin thermometry, measurement of arterial blood flow and resistance in the foot and in the leg, and reactive hyperemia under photoplethysmographic control. Objectively, it could be seen only an increase in the distal skin temperature and an increase of skin blood flow after this treatment.

  18. Tactical Automated Security System (TASS) operational concept field evaluation results

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, D. [Electronic Systems Center, Hanscom AFB, MA (United States); Vinkels, G. [Horizons Technology, Inc., Billerica, MA (United States)

    1995-12-31

    The worldwide quick reaction deployment concept for the Tactical Automated Security System (TASS) was demonstrated to have great value in a base defense operational exercise. TASS equipment was deployed and used as part of the Foal Eagle 94 exercise at Kunsan AB, Korea. The TASS functions of detection, data communication, annunciation, assessment and portable power were evaluated using prototype equipment. The results of the TASS operation during the exercise was very impressive. The friendly forces quickly incorporated the TASS equipment into their defensive operations and were able to intercept and neutralize approximately 80% of the aggressor force penetration attempts at the defensive perimeter.

  19. Some quantitative evaluations on finite difference local and global results

    Directory of Open Access Journals (Sweden)

    Costamagna Eugenio

    2016-06-01

    Full Text Available Refined Schwarz-Christoffel (SC conformal transformations allow us to perform reliable quantitative evaluation of the accuracy of local computation of electric and magnetic fields with limited effort, which can be useful to complement well known comparisons of global results. In this paper some examples are presented for mesh point potentials obtained by means of finite difference (FD methods, but it is possible that similar considerations will be useful in the case of finite element methods (FEM or meshless computations too.

  20. Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution.

    Science.gov (United States)

    Murray, Katie S; Zabor, Emily C; Spaliviero, Massimiliano; Russo, Paul; Bazzi, Wassim M; Musser, John E; Ari Hakimi, A; Bernstein, Melanie L; Dalbagni, Guido; Coleman, Jonathan A; Furberg, Helena

    2016-12-01

    To examine the incidence of secondary primary malignancies in patients with renal cortical neoplasms. Between January 1989 and July 2010, 3647 patients underwent surgery at our institution for a renal cortical neoplasm and were followed through 2012. Occurrence of other malignancies was classified as antecedent, synchronous, or subsequent. All patients with antecedent malignancies (n = 498) and a randomly selected half of those with synchronous malignancies (n = 83) were excluded. The expected number of second primaries was calculated by multiplying Surveillance, Epidemiology, and End Results Program incidence rates of renal cortical neoplasms by person-years at risk within categories of age, sex, and year of diagnosis. The standardized incidence ratio (SIR) was calculated as observed cancers divided by expected incidence of the cancer, with approximation to the exact Poisson test used to obtain confidence intervals (CI) and p values. Of 3066 patients with renal cortical neoplasms, 267 had a second primary cancer; the five most common in men were prostate, colorectal, bladder, lung, and non-Hodgkin's lymphoma; the five most common in women were breast, colorectal, lung, endometrium, and thyroid. Men demonstrated higher than expected thyroid cancer rate (SIR 5.0; 95 % CI 1.83-10.88, p = 0.002), and women had higher than expected rates of stomach cancer (SIR 5.0; 95 % CI 1.61-11.67, p = 0.004) and thyroid cancer (SIR 4.62; 95 % CI 1.69-10.05, p = 0.003). The incidence of certain types of second malignancies may be higher in patients after diagnosis of renal cortical neoplasms compared to the general population. These observations can inform clinical follow-up in kidney cancer survivorship and future research studies.

  1. Evaluation of the groundwater-flow model for the Ohio River alluvial aquifer near Carrollton, Kentucky, updated to conditions in September 2010

    Science.gov (United States)

    Unthank, Michael D.

    2013-01-01

    The Ohio River alluvial aquifer near Carrollton, Ky., is an important water resource for the cities of Carrollton and Ghent, as well as for several industries in the area. The groundwater of the aquifer is the primary source of drinking water in the region and a highly valued natural resource that attracts various water-dependent industries because of its quantity and quality. This report evaluates the performance of a numerical model of the groundwater-flow system in the Ohio River alluvial aquifer near Carrollton, Ky., published by the U.S. Geological Survey in 1999. The original model simulated conditions in November 1995 and was updated to simulate groundwater conditions estimated for September 2010. The files from the calibrated steady-state model of November 1995 conditions were imported into MODFLOW-2005 to update the model to conditions in September 2010. The model input files modified as part of this update were the well and recharge files. The design of the updated model and other input files are the same as the original model. The ability of the updated model to match hydrologic conditions for September 2010 was evaluated by comparing water levels measured in wells to those computed by the model. Water-level measurements were available for 48 wells in September 2010. Overall, the updated model underestimated the water levels at 36 of the 48 measured wells. The average difference between measured water levels and model-computed water levels was 3.4 feet and the maximum difference was 10.9 feet. The root-mean-square error of the simulation was 4.45 for all 48 measured water levels. The updated steady-state model could be improved by introducing more accurate and site-specific estimates of selected field parameters, refined model geometry, and additional numerical methods. Collection of field data to better estimate hydraulic parameters, together with continued review of available data and information from area well operators, could provide the model with

  2. The Development of a Long-Term, Continually Updated Global Solar Resource at 10 km Resolution: Preliminary Results From Test Processing and Continuing Plans

    Science.gov (United States)

    Stackhouse, P.; Perez, R.; Sengupta, M.; Knapp, K.; Cox, Stephen; Mikovitz, J. Colleen; Zhang, T.; Hemker, K.; Schlemmer, J.; Kivalov, S.

    2014-01-01

    Background: Considering the likelihood of global climatic weather pattern changes and the global competition for energy resources, there is an increasing need to provide improved and continuously updated global Earth surface solar resource information. Toward this end, a project was funded under the NASA Applied Science program involving the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC), National Renewable Energy Laboratory (NREL), the State University of New York/Albany (SUNY) and the NOAA National Climatic Data Center (NCDC) to provide NREL with a global long-term advanced global solar mapping production system for improved depiction of historical solar resources and variability and to provide a mechanism for continual updates of solar resource information. This new production system is made possible by the efforts of NOAA and NASA to completely reprocess the International Satellite Cloud Climatology Project (ISCCP) data set that provides satellite visible and infrared radiances together with retrieved cloud and surface properties on a 3-hourly basis beginning from July 1983. The old version of the ISCCP data provided this information for all the world TMs available geosynchronous satellite systems and NOAA TMs AVHRR data sets at a 30 km effective resolution. This new version aims to provide a new and improved satellite calibration at an effective 10 km resolution. Thus, working with SUNY, NASA will develop and test an improved production system that will enable NREL to continually update the Earth TM solar resource. Objective and Methods: In this presentation, we provide a general overview of this project together with samples of the new solar irradiance mapped data products and comparisons to surface measurements at various locations across the world. An assessment of the solar resource values relative to calibration uncertainty and assumptions are presented. Errors resulting assumptions in snow cover and background aerosol

  3. Economic evaluation of initial antiretroviral therapy for HIV-infected patients: an update of Italian guidelines

    Directory of Open Access Journals (Sweden)

    Colombo GL

    2013-10-01

    Full Text Available Giorgio L Colombo,1,2 Sergio Di Matteo,2 Andrea Antinori,3 Massimo Medaglia,4 Silvia Murachelli,3 Giuliano Rizzardini51Department of Drug Sciences, University of Pavia, Pavia, Italy; 2SAVE – Studi Analisi Valutazioni Economiche, Milan, Italy; 3National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy; 4Pharmaceutical Department, L. Sacco Hospital, Milan, Italy; 5First Division of Infectious Disease, L. Sacco Hospital, Milan, Italy Introduction: Highly active antiretroviral therapy (HAART has allowed many HIV-infected patients to enjoy longer survival and a better quality of life. We performed an economic analysis to estimate the cost-effectiveness of HAART regimens in Italy for managing HIV-naïve infected patients with a viral load below 100,000 copies/mL.Patients and methods: The population considered in the model consisted of adult subjects with an HIV viral load below 100,000 copies/mL who received antiretroviral HAART treatment for the first time, according to the Italian National Guidelines with recommendation grade A1. The incremental cost-effectiveness analysis of quality-adjusted life years (QALYs was carried out by means of a Markov model. Both the outcomes (QALYs and the costs were discounted by 3.5%. The time horizon adopted in the model was 10 years. The point of view of the analysis was that of the Italian national health service.Results: The tenofovir (TDF/emtricitabine (FTC/rilpivirine (RPV single-tablet regimen (STR (€7,417.00 revealed the lowest mean treatment cost. TDF/FTC + raltegravir (RAL showed a better quality of life (0.906 QALY/year, followed by TDF/FTC/RPV (STR; 0.900 QALY/year, TDF/FTC + RPV (multipill regimen (0.889 QALY/year, and TDF/FTC + atazanavir (ATV/r (0.886 QALY/year. TDF/FTC/RPV (STR appeared to be the most cost-effective therapeutic choice (€13,655.00, followed by TDF/FTC + RPV (multipill regimen (€15,803.00, and TDF/FTC + efavirenz (EFV (€16,181.00. The sensitivity analysis on

  4. Steel Containment Vessel Model Test: Results and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Costello, J.F.; Hashimote, T.; Hessheimer, M.F.; Luk, V.K.

    1999-03-01

    A high pressure test of the steel containment vessel (SCV) model was conducted on December 11-12, 1996 at Sandia National Laboratories, Albuquerque, NM, USA. The test model is a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of an improved Mark II boiling water reactor (BWR) containment. A concentric steel contact structure (CS), installed over the SCV model and separated at a nominally uniform distance from it, provided a simplified representation of a reactor shield building in the actual plant. The SCV model and contact structure were instrumented with strain gages and displacement transducers to record the deformation behavior of the SCV model during the high pressure test. This paper summarizes the conduct and the results of the high pressure test and discusses the posttest metallurgical evaluation results on specimens removed from the SCV model.

  5. Evaluation of the screening test results before marriage

    Directory of Open Access Journals (Sweden)

    Süleyman Durmaz

    2011-09-01

    Full Text Available Objectives: Human immunodeficiency virus (HIV, Hepatitis B and Hepatitis C viruses and Treponema pallidum are parenterally and sexually transmitted infection agents. Screening test is made before marriage to pre-marital couples legally under the relevant legislation and legal procedures in our country; applicants are evaluated in terms of sexually transmitted diseases. The aim of this study is to evaluate pre-marital test results for HBsAg, anti-HCV, anti-HIV I/II and Treponema pallidum.Materials and methods: To make screening test before marriage, randomized 117 patients who were applied to Kızıltepe General Hospital of Infectious Diseases and Clinical Microbiology, were included in this study between January 2011 and March 2011. Of these patients, 64 were women (average age 24.7±5.7, and 55 were males (mean age 24.7±4.7. HBsAg, anti-HCV and anti-HIV I/II tests of the patients were studied by macro-ELISA device (ECIQ Vitros, Ortho Clinical Diagnostics, USA, screening of anti-Treponema pallidum IgG, IgA and IgM antibodies were studied by immunochromatographic rapid test (syphilis syphilis 3.0, Standard Diagnostics, inc. Korea.Results: Of the 119 patients, five patients (4.2% were positive for HBsAg (3 male and 2 female. Anti-HCV, anti-HIV I/II and anti-Treponema pallidum antibodies were negative in all patients.Conclusion: HBsAg test result which was obtained in present study has been found consistent with HBsAg positivity rate in our region. As a result of screening test that was done before marriage will continue to believe that the increased importance of the prevention of sexually transmitted diseases. J Clin Exp Invest 2011; 2 (3: 292-294.

  6. Evaluation of cervicovaginal smear results at postmenopausal period

    Directory of Open Access Journals (Sweden)

    Sefa Kelekci

    2016-02-01

    Full Text Available This study evaluates the statistical analysis of cervicovaginal smear results at postmenopausal period accompanied by literature. Cervicovaginal smear results of 894 postmenopausal women were evaluated retrospectively according to the 2001 Bethesda system (BS in Adana Numune Training and Research Hospital of Obstetrics and Gynecology Clinic from 2007–2010. The study found, normal results on 287 patients (32.1%, benign findings on 556 patients (62.2%, abnormal epithelial cell changes on 48 patients (5.36% and malignant changes on 3 patients (0.33%. The abnormal epithelial changes were observed to be atypical cells of undetermined significance (ASC-US for 22 patients (2.46%, low-grade squamous intraepithelial lesion (LSIL for 11 patients (1.23%, high-grade squamous intraepithelial lesion(HSIL for 7 patients (0.78%, findings that cannot exclude a high-grade squamous intraepithelial lesion (ASC-H for 6 patients (0.55% and atypical glandular cells-not otherwise specified (AGC-NOS for 2 patients (0.22%. Malignant results were 2 squamous cell carcinomas (SCC (0.22% and 1 adenocarcinoma (ACC (0.11%. Cervical cancer screening programs should be expanded and Pap smear screening should be applied to all postmenopausal women. The longer time span involved from premalignant lesions to cancer improves our chance for the diagnosis and treatment. As the incidence of invasive cancer increases in menopausal period, gynecological smear examination and regular check-up are crucial. A high rate of abnormalities of epithelial cells was detected in this study.

  7. Uniform presentation of process evaluation results facilitates the evaluation of complex interventions: development of a graph.

    Science.gov (United States)

    Bakker, Franka C; Persoon, Anke; Schoon, Yvonne; Olde Rikkert, Marcel G M

    2015-02-01

    Process evaluation is a highly essential element for the increasing number of studies regarding multi-component interventions. Yet, researchers are challenged to collect and present appropriate process outcomes in such way that it is easy and valuable to be used by other researchers and policy makers in interpreting and comparing intervention effects because of the absence of standards for conducting and publishing process evaluation. This article describes the development of a method to concisely summarize the results of process evaluations of complex multi-component interventions. Development of a graph with the aim to facilitate the reporting of process evaluation's results, based on a narrative review of the literature for process measures used in complex interventions for elderly people. Seventeen articles of process evaluations alongside effect studies of complex interventions were reviewed. From these articles, it was found that process evaluations should address whether the intervention (1) was implemented successfully; (2) was evaluated properly; and (3) can be continued in the future. A flow chart based on the essential components of an adequate process evaluation was developed. A simplified but highly informative figure reporting a summary of the results of the process evaluation is proposed and its use is explained by administering the figure to two studies including a process and effect evaluation of a complex intervention. A graphical approach - which includes the core results of process evaluation and can be used directly in reporting effectiveness studies - will help researchers and policy makers to interpret and compare effects of complex multi-component interventions. © 2014 John Wiley & Sons, Ltd.

  8. Website updates

    Data.gov (United States)

    National Aeronautics and Space Administration — Updates to Website: (Please add new items at the top of this description with the date of the website change) May 9, 2012: Uploaded experimental data in matlab...

  9. Circular Updates

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Circular Updates are periodic sequentially numbered instructions to debriefing staff and observers informing them of changes or additions to scientific and specimen...

  10. Cybersecurity Update

    CERN Document Server

    Heagerty, Denise

    2008-01-01

    An update on recent security issues and vulnerabilities affecting Windows, Linux and Mac platforms. This talk is based on contributions and input from a range of colleagues both within and outside CERN. It covers clients, servers and control systems.

  11. Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study

    Directory of Open Access Journals (Sweden)

    Anja Vogt

    2007-09-01

    Full Text Available Anja Vogt1, Ursula Kassner1, Ulrike Hostalek2, Elisabeth Steinhagen-Thiessen11Charite-Universitatsmedizin Berlin, Germany; 2Merck KGaA, Darmstadt, GermanyAbstract: Low HDL-cholesterol (<1.02 mmol/L [40 mg/dL] in men or <1.29 mmol/L [50 mg/dL] in women occurs in about one-third of European patients with dyslipidemia and is an independent cardiovascular risk factor. Simultaneous correction of low HDL-cholesterol and high totalcholesterol and LDL-cholesterol may provide reductions in cardiovascular morbidity and mortality beyond those possible with statins alone. Nicotinic acid (niacin in the US is the most effective means of increasing HDL-cholesterol available and has been shown to reduce cardiovascular event rates significantly. Niaspan® (prolonged-release nicotinic acid provides a convenient, once-daily means of administering nicotinic acid. Clinical studies with Niaspan® have demonstrated marked, long-term increases in HDL-cholesterol with additional useful benefits on triglycerides, LDLcholesterol, and lipid sub-profiles. The NAUTILUS study demonstrated the beneficial efficacy and tolerability profiles of Niaspan® in a usual-care setting. The most common side-effect of Niaspan® is flushing, which infrequently causes treatment discontinuation and which usually subsides over continued treatment. The ARBITER 2 and ARBITER 3 studies showed 1–2 years of treatment with Niaspan® plus a statin induced regression of atherosclerosis in patients with coronary artery disease. The effect of Niaspan®-statin treatment, relative to a statin alone, on clinical cardiovascular outcomes is currently under evaluation. Niaspan® represents a practical means of correcting low HDL-cholesterol, an independent risk factor for adverse cardiovascular outcomes.Keywords: prolonged-release nicotinic acid, Niaspan®, niacin, dyslipidemia, HDL-cholesterol cardiovascular risk

  12. Results of evaluation of tailing dumps dust intensity

    Directory of Open Access Journals (Sweden)

    Masloboev V. A.

    2016-03-01

    Full Text Available A set of most acceptable and well-known methods of dust intensity evaluation has been defined and tested (dependence of Westphal D. L. et al. and DEAD scheme based on the analysis of exiting approaches (deserts, tailing dumps, etc.. The description of the chosen methods has been given. The determination of dynamic velocity u* and velocity at the height of +10 m above the dusting surface u10 which are necessary to evaluate the dust intensity has been demonstrated. The method is based on two-dimensional numerical model of atmosphere aerodynamics in the area of "tailing dumps of ANOF-2 ‒ the town of Apatity". The study provides calculations of horizontal velocity at the height of +10 m above the dusting surface at the wind speed varying from 5 to 23 m/sec. The work also suggests the results of graphical data processing related to tailing grain size distribution from the surface of the firmly established surface of the tailing dumps of ANOF-2. Comparative analysis has been given and the peculiarities of interval (based on grains sizes dust intensity of the tailing dumps of ANOF-2 have been shown using the dependence of Westphal D. L. et al. and DEAD scheme within the wind speed range. The received values of dust intensity at the lower range limit are close to the "maximum specific dust off" value which is used by project specialists for documentation development

  13. What drives the perceptual change resulting from speech motor adaptation? Evaluation of hypotheses in a Bayesian modeling framework

    Science.gov (United States)

    Perrier, Pascal; Schwartz, Jean-Luc; Diard, Julien

    2018-01-01

    Shifts in perceptual boundaries resulting from speech motor learning induced by perturbations of the auditory feedback were taken as evidence for the involvement of motor functions in auditory speech perception. Beyond this general statement, the precise mechanisms underlying this involvement are not yet fully understood. In this paper we propose a quantitative evaluation of some hypotheses concerning the motor and auditory updates that could result from motor learning, in the context of various assumptions about the roles of the auditory and somatosensory pathways in speech perception. This analysis was made possible thanks to the use of a Bayesian model that implements these hypotheses by expressing the relationships between speech production and speech perception in a joint probability distribution. The evaluation focuses on how the hypotheses can (1) predict the location of perceptual boundary shifts once the perturbation has been removed, (2) account for the magnitude of the compensation in presence of the perturbation, and (3) describe the correlation between these two behavioral characteristics. Experimental findings about changes in speech perception following adaptation to auditory feedback perturbations serve as reference. Simulations suggest that they are compatible with a framework in which motor adaptation updates both the auditory-motor internal model and the auditory characterization of the perturbed phoneme, and where perception involves both auditory and somatosensory pathways. PMID:29357357

  14. Role and Evaluation of Interlaboratory Comparison Results in Laboratory Accreditation

    Science.gov (United States)

    Bode, P.

    2008-08-01

    Participation in interlaboratory comparisons provides laboratories an opportunity for independent assessment of their analytical performance, both in absolute way and in comparison with those by other techniques. However, such comparisons are hindered by differences in the way laboratories participate, e.g. at best measurement capability or under routine conditions. Neutron activation analysis laboratories, determining total mass fractions, often see themselves classified as `outliers' since the majority of other participants employ techniques with incomplete digestion methods. These considerations are discussed in relation to the way results from interlaboratory comparisons are evaluated by accreditation bodies following the requirements of Clause 5.9.1 of the ISO/IEC 17025:2005. The discussion and conclusions come largely forth from experiences in the author's own laboratory.

  15. Radial Access Reduces Mortality in Patients With Acute Coronary Syndromes: Results From an Updated Trial Sequential Analysis of Randomized Trials.

    Science.gov (United States)

    Andò, Giuseppe; Capodanno, Davide

    2016-04-11

    The authors sought to investigate whether the cumulative evidence coming from randomized studies has reached the necessary power to consider radial access as a bleeding avoidance strategy that reduces mortality and ischemic endpoints in patients with acute coronary syndromes (ACS). Studies in ACS patients have reached conflicting conclusions about the impact of radial access in improving ischemic outcomes in addition to the established bleeding benefit. English-language publications and abstracts of major cardiovascular meetings until October 2015 were scrutinized. Study quality, patient characteristics, procedural data, and outcomes were extracted. Data were pooled in random effects meta-analyses with classic and trial sequential techniques. Trial sequential analysis combines the a priori information size calculation needed to allow for clinically meaningful statistical inference with the adjustment of thresholds for which results are considered significant. Seventeen studies, encompassing data from 19,328 patients, were pooled. Radial access was found to reduce mortality (relative risk [RR]: 0.73; 95% confidence interval [CI]: 0.60 to 0.88; p = 0.001), major adverse cardiovascular events (RR: 0.86; 95% CI: 0.77 to 0.95; p = 0.005), and major bleeding (RR: 0.60; 95% CI: 0.48 to 0.76; p < 0.001). Multiple sensitivity analyses showed consistent results, and trial sequential analysis suggested firm evidence for a meaningful reduction in mortality with radial access. Radial access reduces mortality compared with femoral access in ACS patients undergoing invasive management. This benefit is paralleled by consistent reductions in major adverse cardiovascular events and major bleeding, supporting radial access as the default strategy for cardiac catheterization in patients with ACS. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  16. The SBR MOX and UO{sub 2} comparison test in gas flow rig IFA-633: an update of results

    Energy Technology Data Exchange (ETDEWEB)

    Roe, Eirik; Rossiter, Glyn

    2005-09-15

    The gas flow rig IFA-633 has been irradiated in the Halden reactor since March 1999 and has now completed 10 cycles of irradiation achieving a rig average burnup of approx35 MWd/kgOxide. In addition to data on the fission product release behaviour of commercial SBR MOX and UO{sub 2} fuel, the IFA-633.1 experiment is providing data on thermal performance, fuel densification, fuel swelling and pellet cracking and relocation. Modelling of the fuel temperatures during start-of-life ramps suggested that the start-of-life SBR MOX thermal conductivity is approx 8% lower than that of UO{sub 2}. SCRAM data show a decrease of estimated fuel time constants for increasing burnup for both the MOX and UO{sub 2} rods. The measured amount of in-pile densification is somewhat greater in the MOX than the UO{sub 2} fuel and was found to be a direct result of the difference in the original fuel grain sizes. Thus, the data obtained from IFA-633 indicate that the in-pile densification of SBR MOX fuel can be described by the same model used for standard UO{sub 2} leading to the conclusions that the inherent processes responsible for in-pile densification in both fuel types are the same. Following the initial densification there is a gradual increase in the fuel stack length due to fuel swelling. It is clear that the fuel volumetric swelling rate of both fuels is comparable and equates to approx 0.7 vol% per 10 MWd/kgOxide. Two sets of gas flow measurements have been performed on IFA-633 during its tenth cycle of irradiation. The measured R/B values were analysed using both classical and fractal methodologies. The recoil R/B and S/V values from the classical analysis are in the ranges observed for UO{sub 2} and MOX fuel in other gas flow rigs at similar burnups. The variations in the classical and fractal analysis results between the rods reflect the differences in rod dimensions, fill gas, irradiation history, fuel grain size and fuel type. (Author)

  17. King County Metro Transit Hybrid Articulated Buses: Final Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Walkowicz, K.

    2006-12-01

    Final technical report compares and evaluates new diesel and diesel hybrid-electric articulated buses operated as part of the King County Metro Transit (KC Metro) fleet in Seattle, Washington. The evaluation lasted 12 months.

  18. SEE - Sight Effectiveness Enhancement. Results of the automotive evaluation

    DEFF Research Database (Denmark)

    Andersen, V.; Hansen, K.D.; Cathala, T.

    2006-01-01

    In the SEE project two parallel evaluations have been conducted, an experimental trial of the automotive and another of the aeronautical application. The evaluations have measured the efficiency and HMI (human-machine interaction) characteristics of theSEE prototype. This report covers the automo......In the SEE project two parallel evaluations have been conducted, an experimental trial of the automotive and another of the aeronautical application. The evaluations have measured the efficiency and HMI (human-machine interaction) characteristics of theSEE prototype. This report covers...... the automotive part of the evaluation. The evaluation of the automotive application was carried out in computer simulated environments and followed the general objectives of the evaluation described in ‘Definition of theEvaluation Plan’ . The field experiment discussed, however, was given up due to lack...

  19. Update on the everolimus-eluting coronary stent system: results and implications from the SPIRIT clinical trial program

    Directory of Open Access Journals (Sweden)

    R Michael Kirchner

    2009-12-01

    Full Text Available R Michael Kirchner, J Dawn AbbottDepartment of Cardiology, Rhode Island Hospital, Brown Medical School, Providence, RI, USAAbstract: Drug-eluting stents (DES have had a major impact in interventional cardiology. Compared to bare metal stents, they significantly reduce restenosis and the need for target vessel revascularization. Four DES are available in the US, the first-generation sirolimuseluting (Cypher® and paclitaxel-eluting (Taxus® stents and later approved second-generation everolimus-eluting (Xience V® and zotarolimus-eluting (Endeavor® stents. The Xience V stent was approved on the basis of clinical efficacy and safety data from 3 studies in the SPIRIT clinical trial program. Within this trial series, the Xience V was superior to its bare metal stent counterpart, the Vision® stent, and noninferior to the paclitaxel-eluting stent for target vessel failure at 9 months. This review provides a comprehensive assessment of the data derived from both the pre- and post-approval randomized controlled trials and registry studies of Xience V that comprise the SPIRIT clinical trial program including recently published mid-term outcomes. The implications of the results in terms of interventional practice will be discussed.Keywords: cobalt-chromium, drug-eluting stent, everolimus, percutaneous coronary intervention, Xience V

  20. Diffuse reflectance spectra measured in vivo in human tissues during Photofrin-mediated pleural photodynamic therapy: updated results

    Science.gov (United States)

    Finlay, Jarod C.; Zhu, Timothy C.; Dimofte, Andreea; Friedberg, Joseph S.; Cengel, Keith A.; Hahn, Stephen M.

    2009-02-01

    We present the results of a series of spectroscopic measurements made in vivo in patients undergoing photodynamic therapy (PDT). The patients studied here were enrolled in Phase II clinical trials of Photofrin-mediated PDT for the treatment of non-small cell lung cancer and cancers with pleural effusion. Patients were given Photofrin at dose of 2 mg per kg body weight 24 hours prior to treatment. Each patient received surgical debulking of the tumor followed by intracavity PDT at 630nm to a dose of 60 J/cm2. Dose was monitored continuously using implanted isotropic fiber-based light detectors. We measured the diffuse reflectance spectra before and after PDT in various positions within the cavity, including tumor, diaphragm, pericardium, skin, and chest wall muscle in 10 patients. The measurements were acquired using a specially designed fiber optic-based probe consisting of one fluorescence excitation fiber, one white light delivery fiber, and 9 detection fibers spaced at distances from 0.36 to 7.8 mm from the source, all of which are imaged via a spectrograph onto a CCD, allowing measurement of radially-resolved diffuse reflectance and fluorescence spectra. The absorption spectra were analyzed using an analytical model of light propagation in diffuse media based on the P3 approximation to radiative transport, assuming a known basis set of absorbers including hemoglobin in its oxygenated and deoxygenated forms and Photofrin. We find significant variation in hemodynamics and sensitizer concentration among patients and within tissues in a single patient.

  1. Evaluation of patch test results in patients with contact dermatitis

    Directory of Open Access Journals (Sweden)

    Yavuz Yeşilova

    2011-12-01

    Full Text Available Objectives: Patch test is the most reliable method to diagnose allergic contact dermatitis and to find out the responsible contact allergen. The aim of this retrospective study was to evaluate the patch test results of patients with contact dermatitis in our region.Materials and methods: One Hundred fifty patients (84 female and 66 male with contact dermatitis were patch tested with European standard test series. The testing has been standardized by the international Contact Dermatitis Research Group (ICDRG.Results: A majority of the lesions (36% were localized on the hands. In 31 female (58,4% and 21 male (4,6% patients (a total of 72 patients there were positive allergic reactions to at least one chemical. Nickel sulphate (13,3%, potassium dichromate (11,3% and cobalt chloride (8,6% were the most often allergens reacted.Conclusion: Nickel sensitivity is more common. Comparing with healthy controls contact sensitization may be more prevalent in patients with contact dermatitis.

  2. Evaluating the Impact of Database Heterogeneity on Observational Study Results

    Science.gov (United States)

    Madigan, David; Ryan, Patrick B.; Schuemie, Martijn; Stang, Paul E.; Overhage, J. Marc; Hartzema, Abraham G.; Suchard, Marc A.; DuMouchel, William; Berlin, Jesse A.

    2013-01-01

    Clinical studies that use observational databases to evaluate the effects of medical products have become commonplace. Such studies begin by selecting a particular database, a decision that published papers invariably report but do not discuss. Studies of the same issue in different databases, however, can and do generate different results, sometimes with strikingly different clinical implications. In this paper, we systematically study heterogeneity among databases, holding other study methods constant, by exploring relative risk estimates for 53 drug-outcome pairs and 2 widely used study designs (cohort studies and self-controlled case series) across 10 observational databases. When holding the study design constant, our analysis shows that estimated relative risks range from a statistically significant decreased risk to a statistically significant increased risk in 11 of 53 (21%) of drug-outcome pairs that use a cohort design and 19 of 53 (36%) of drug-outcome pairs that use a self-controlled case series design. This exceeds the proportion of pairs that were consistent across databases in both direction and statistical significance, which was 9 of 53 (17%) for cohort studies and 5 of 53 (9%) for self-controlled case series. Our findings show that clinical studies that use observational databases can be sensitive to the choice of database. More attention is needed to consider how the choice of data source may be affecting results. PMID:23648805

  3. 16(th) IHIW: analysis of HLA population data, with updated results for 1996 to 2012 workshop data (AHPD project report).

    Science.gov (United States)

    Riccio, M E; Buhler, S; Nunes, J M; Vangenot, C; Cuénod, M; Currat, M; Di, D; Andreani, M; Boldyreva, M; Chambers, G; Chernova, M; Chiaroni, J; Darke, C; Di Cristofaro, J; Dubois, V; Dunn, P; Edinur, H A; Elamin, N; Eliaou, J-F; Grubic, Z; Jaatinen, T; Kanga, U; Kervaire, B; Kolesar, L; Kunachiwa, W; Lokki, M L; Mehra, N; Nicoloso, G; Paakkanen, R; Voniatis, D Papaioannou; Papasteriades, C; Poli, F; Richard, L; Romón Alonso, I; Slavčev, A; Sulcebe, G; Suslova, T; Testi, M; Tiercy, J-M; Varnavidou, A; Vidan-Jeras, B; Wennerström, A; Sanchez-Mazas, A

    2013-02-01

    We present here the results of the Analysis of HLA Population Data (AHPD) project of the 16th International HLA and Immunogenetics Workshop (16IHIW) held in Liverpool in May-June 2012. Thanks to the collaboration of 25 laboratories from 18 different countries, HLA genotypic data for 59 new population samples (either well-defined populations or donor registry samples) were gathered and 55 were analysed statistically following HLA-NET recommendations. The new data included, among others, large sets of well-defined populations from north-east Europe and West Asia, as well as many donor registry data from European countries. The Gene[rate] computer tools were combined to create a Gene[rate] computer pipeline to automatically (i) estimate allele frequencies by an expectation-maximization algorithm accommodating ambiguities, (ii) estimate heterozygosity, (iii) test for Hardy-Weinberg equilibrium (HWE), (iv) test for selective neutrality, (v) generate frequency graphs and summary statistics for each sample at each locus and (vi) plot multidimensional scaling (MDS) analyses comparing the new samples with previous IHIW data. Intrapopulation analyses show that HWE is rarely rejected, while neutrality tests often indicate a significant excess of heterozygotes compared with neutral expectations. The comparison of the 16IHIW AHPD data with data collected during previous workshops (12th-15th) shows that geography is an excellent predictor of HLA genetic differentiations for HLA-A, -B and -DRB1 loci but not for HLA-DQ, whose patterns are probably more influenced by natural selection. In Europe, HLA genetic variation clearly follows a north to south-east axis despite a low level of differentiation between European, North African and West Asian populations. Pacific populations are genetically close to Austronesian-speaking South-East Asian and Taiwanese populations, in agreement with current theories on the peopling of Oceania. Thanks to this project, HLA genetic variation is more

  4. [Penile protheses multicentre practice evaluation, results after 282 procedures].

    Science.gov (United States)

    Menard, Johann; Tremeaux, Jack-Charles; Faix, Antoine; Staerman, Frédéric

    2007-04-01

    Multicentre practice evaluation in the field of penile prostheses based on the Club des Implanteurs de Prosthèses Péniennes (CIPP) database. 282 penile prostheses, including 276 inflatable prostheses (97.8%), were implanted in 254 patients between 1996 and 2005 in three centres (1 public and 2 private). Preoperative data (patient's age, aetiology and duration of erectile dysfunction, preliminary treatments) and intraoperative data (type of implant used, surgical approach) were recorded. Postoperative complications were studied and postoperative erectile function was evaluated by a self-administered questionnaire (IIEF). The mean follow-up was 27.7 months. Penile prostheses were implanted after an average of 39.2 months of erectile dysfunction in patients with a mean age of 58.6 years. The main aetiologies were arterial disease (35.3%), diabetes (22.8%) and radical prostatectomy (16.5%). The postoperative sepsis rate was 2.2% and the mechanical dysfunction rate was 7.5% at the beginning of the operators' experience. The rate of other complications requiring repeat surgery (erosion, migration, self-inflation) was 1.8% at the beginning of the operators' experience. The septic risk was increased (7.6%) in the presence of diabetes (p = 0.01). The postoperative overall satisfaction was 86.7% and the IIEF score increased from 20.5 +/- 11.8 preoperatively to 68.9 +/- 5.4 postoperatively. Penile prostheses achieve a high postoperative satisfaction score with a low complication rate. However, they are only indicated after failure of less invasive treatments and must be implanted by experienced operators. These results are comparable to those of large international single-centre series.

  5. Thyroid dysfunction during pregnancy and evaluation of its results

    Directory of Open Access Journals (Sweden)

    Fatih Taşkesen

    2011-06-01

    Full Text Available In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women.Materials and methos: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH, free tri-iyodotironin (T3, free thyroxine (T4 levels for all patients were studied. Antithyroidal peroxidase (anti-TPO and Anti-thyroglobulin (anti-Tg parameters were measured if they were necessary. The relationship between thyroid functions and complications such as eclampsia, preeclampsia, maternal anemia, postpartum hemorrhage, fetal anomalies, shoulder dystocia, neonatal hypoglycemia was examined.Results: Hypothyroidism was found 18 of cases and hyperthyroidism was found 4 of them. The mean age of patients in the study was 26.42 (± 8.42. The mean values were 1.86 ± 0.19 μIU/mL for TSH, 1.15 ± 0.29 ng/mL for free T4 and 2.90 ± 0.31 pg/mL for free T3 respectively. Hashimoto’s thyroiditis (9 cases, 50 % was the most frequent etiology for patients with hypothyroidism. Other etiologic factors for hypothyroidism were found to be for 4 cases as (22.2%, iatrogenic (previously undergone thyroidectomy and 5 cases as (37.8% a lack of iodine. Maternal anemia was observed in 5 (27.78% cases with hypothyroidism. Preeclampsia was observed 16.67% in patients with hypothyroidism.Conclusion: Observed thyroid dysfunction in pregnant women may cause serious maternal and fetal complications. For disorders of thyroid function during pregnancy, to provide the necessary treatment at the appropriate time is important to prevent complications of mother and fetus. J Clin Exp Invest 2011;2(2:196-201

  6. FDI World Dental Federation - clinical criteria for the evaluation of direct and indirect restorations. Update and clinical examples.

    Science.gov (United States)

    Hickel, Reinhard; Peschke, Arnd; Tyas, Martin; Mjör, Ivar; Bayne, Stephen; Peters, Mathilde; Hiller, Karl-Anton; Randall, Ross; Vanherle, Guido; Heintze, Siegward D

    2010-08-01

    In 2007, new clinical criteria were approved by the FDI World Dental Federation and simultaneously published in three dental journals. The criteria were categorized into three groups: esthetic parameters (four criteria), functional parameters (six criteria), and biological parameters (six criteria). Each criterion can be expressed with five scores, three for acceptable and two for non-acceptable (one for reparable and one for replacement). The criteria have been used in several clinical studies since 2007, and the resulting experience in their application has led to a requirement to modify some of the criteria and scores. The two major alterations involve staining and approximal contacts. As staining of the margins and the surface have different causes, both phenomena do not appear simultaneously. Thus, staining has been differentiated into marginal staining and surface staining. The approximal contact now appears under the name "approximal anatomic form" as the approximal contour is a specific, often non-esthetic issue that cannot be integrated into the criterion "esthetic anatomical form". In 2008, a web-based training and calibration tool called e-calib (www.e-calib.info) was made available. Clinical investigators and other research workers can train and calibrate themselves interactively by assessing clinical cases of posterior restorations, which are presented as high quality pictures. Currently, about 300 clinical cases are included in the database which is regularly updated. Training for 8 of the 16 clinical criteria is available in the program: "Surface luster"; "Staining (surface, margins)"; "Color match and translucency"; "Esthetic anatomical form"; "Fracture of material and retention"; "Marginal adaptation"; "Recurrence of caries, erosion, abfraction"; and "Tooth integrity (enamel cracks, tooth fractures)". Typical clinical cases are presented for each of these eight criteria and their corresponding five scores.

  7. FDI World Dental Federation: clinical criteria for the evaluation of direct and indirect restorations-update and clinical examples.

    Science.gov (United States)

    Hickel, Reinhard; Peschke, Arnd; Tyas, Martin; Mjör, Ivar; Bayne, Stephen; Peters, Mathilde; Hiller, Karl-Anton; Randall, Ross; Vanherle, Guido; Heintze, Siegward D

    2010-08-01

    In 2007, new clinical criteria were approved by the FDI World Dental Federation and simultaneously published in three dental journals. The criteria were categorized into three groups: esthetic parameters (four criteria), functional parameters (six criteria) and biological parameters (six criteria). Each criterion can be expressed with five scores, three for acceptable and two for non-acceptable (one for reparable and one for replacement). The criteria have been used in several clinical studies since 2007, and the resulting experience in their application has led to a requirement to modify some of the criteria and scores. The two major alterations involve staining and approximal contacts. As staining of the margins and the surface has different causes, both phenomena do not appear simultaneously. Thus, staining has been differentiated into marginal staining and surface staining. The approximal contact now appears under the name "approximal anatomic form" as the approximal contour is a specific, often non-esthetic issue that cannot be integrated into the criterion "esthetic anatomical form". In 2008, a web-based training and calibration tool called e-calib ( www.e-calib.info ) was made available. Clinical investigators and other research workers can train and calibrate themselves interactively by assessing clinical cases of posterior restorations which are presented as high-quality pictures. Currently, about 300 clinical cases are included in the database which is regularly updated. Training for eight of the 16 clinical criteria is available in the program: "Surface lustre"; "Staining (surface, margins)"; "Color match and translucency"; Esthetic anatomical form"; "Fracture of material and retention"; "Marginal adaptation"; "Recurrence of caries, erosion, abfraction"; and "Tooth integrity (enamel cracks, tooth fractures)". Typical clinical cases are presented for each of these eight criteria and their corresponding five scores.

  8. Updated evaluation of the migration of styrene monomer and oligomers from polystyrene food contact materials to foods and food simulants.

    Science.gov (United States)

    Genualdi, Susan; Nyman, Patricia; Begley, Timothy

    2014-04-01

    Due to the 2011 labelling of styrene monomer as "reasonably anticipated to be a human carcinogen" by the National Institutes of Health's National Toxicology Program (NTP) and the controversy over whether styrene oligomers mimic the physiological effects of estrogen, an updated review of styrene monomer and oligomers in food and food contact materials (FCMs) was performed. The concentrations of styrene monomer and oligomers were determined in 24 polystyrene (PS) products and ranged from 9.3 to 3100 mg kg(-1) for the styrene monomer, 130-2900 mg kg(-1) for the sum of three styrene dimers, and 220-16,000 mg kg(-1) for the sum of six styrene trimers. Foods in contact with PS packaging had styrene monomer concentrations ranging from 2.6 to 163 ng g(-1); dimer concentrations from the limit of quantitation (LOQ) to 4.8 ng g(-1) and trimer concentrations were all below the LOQ (2 ng g(-1)). Diffusion coefficients (Dp) and partition coefficients (K) were also calculated for styrene dimers and trimers. The results presented here indicate that styrene monomer concentrations in foods have not significantly changed since the 1980s and monomer concentrations in food packaging quantified in this study were all below USFDA limits. Although styrene dimers and trimers are present in higher concentrations in PS FCMs than the monomer, their migration to food is limited because of their high K values (4 × 10(2) to 2 × 10(6)) and their low diffusion coefficients in PS products. Additionally, diffusion coefficients calculated using USFDA-recommended food simulants and Arrhenius plots describing the temperature dependence of styrene dimers and trimers can be used in future calculations of dietary intake of the styrene oligomers.

  9. ECO Update / Groundwater Foum Issue Paper: Evaluating Ground-Water/Surface-Water Transition Zones in Ecological Risk Assessments

    Science.gov (United States)

    This ECO Update builds on the standard approach to ERA (U.S. EPA 1997), by providing a framework for incorporating groundwater/surface-water (GW/SW) interactions into existing ERAs (see U.S. EPA 1997 and 2001a for an introduction to ecological risk....

  10. Ultrasonic Evaluation of Deeply Located Trabecular Bones - Preliminary Results

    Science.gov (United States)

    Cieślik, Lucyna; Litniewski, Jerzy

    The analysis of ultrasonic signals scattered by soft tissues have been successfully applied for their characterization. Similarly, the trabecular bone backscattered signal contains information about the properties of the bone structure. Therefore scattering-based ultrasonic technique potentially enables the assessment of microstructure characteristics of a bone. The femoral neck fracture often occurs in the course of osteoporosis and can lead to severe complications. Therefore assessment of femoral bone microstructure and condition is important and essential for the diagnosis and treatment monitoring. As far most of the trabecular bone investigations have been performed in vitro. The only in vivo measurements were carried out in transmission and mostly concerned estimation of the attenuation in heel bone. We have built the ultrasonic scanner that could be useful in acquiring the RF (Radio Frequency) echoes backscattered by the trabecular bone in vivo. Moreover, the bone scanner provides data not only from heel bone but from deeply located bones as well (e.g. femoral bone). It can be also used for easily accessible bones like heel bone or breastbone. In this case a gel-pad is applied to assure focusing of ultrasound in trabecular bone (approximately 10 mm beneath the cortical bone). This study presents preliminary results of the attenuating properties evaluation of trabecular bone from the ultrasonic echoes backscattered by heel bone and femoral neck.

  11. Evaluation of flat-Earth approximation results for geopotential missions.

    Science.gov (United States)

    Tapley, M. B.

    1997-04-01

    Simplified calculations can approximate the formal uncertainties in estimates of the spherical harmonic coefficients representing the Earth's gravitational potential. The calculations model the Earth locally as a plane, producing errors negligible for wavelengths shorter than the radius of the Earth. Information derived from observations of low altitude polar orbiting satellites is considered. With some constraints, the final model uncertainties derive from a priori gravitational field information, specific orbital elements, and parameters describing instrumentation characteristics. The author demonstrates how to refine the technique to accept inputs from the currently operational Navstar Global Positioning System (GPS) constellation and how to use information from partial tensor gravitational gradiometers. This approach is beneficial when evaluating prospective satellite geodesy missions because the covariance analyses for various mission scenarios can be made efficiently and expeditiously. The author demonstrates the utility of the flat Earth approach by comparing results with those of more elaborate and time consuming calculations performed for the European Space Agency ARISTOTELES proposed geopotential mapping mission, the NASA Gravity Probe B Relativity mission, and the NASA/Center National d'Etudes Spatiales Topographic Ocean Experiment Satellite (TOPEX)/Poseidon mission.

  12. BC Transit Fuel Cell Bus Project: Evaluation Results Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-02-01

    This report evaluates a fuel cell electric bus demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. This evaluation report covers two years of revenue service data on the buses from April 2011 through March 2013.

  13. Benchmarking Evaluation Results for Prototype Extravehicular Activity Gloves

    Science.gov (United States)

    Aitchison, Lindsay; McFarland, Shane

    2012-01-01

    subjects representing the design ]to hand anthropometry completed range of motion, grip/pinch strength, dexterity, and fit evaluations for each glove design in both the unpressurized and pressurized conditions. This paper provides a comparison of the test results along with a detailed description of hardware and test methodologies used.

  14. Difficulties in evaluating abnormal lead screening results in children.

    Science.gov (United States)

    Block, B; Szekely, K; Escobar, M

    1996-01-01

    This report chronicles efforts to provide follow-up care for children with abnormal whole blood lead concentrations using the 1991 Centers for Disease Control and Prevention (CDC) guidelines in the Family Health Center at Shadyside Hospital in Pittsburgh. An automated surveillance module found all children with abnormal lead concentrations obtained between January 1994 and July 1995 and singled out children who were overdue for follow-up. Automated physician reminders and nursing case management were used to improve care and documentation. Longitudinal case summaries were used to evaluate care. All 99 children with a lead concentration of 10 micrograms/dL or greater had a documented follow-up plan. Twenty-nine children (47 percent) who had a lead concentration of 10 to 14 micrograms/dL, 23 (100 percent) who had a lead concentration of 15 to 19 micrograms/dL, and 8 (100 percent) who had a lead concentration of 20 micrograms/dL or greater had at least one follow-up lead concentration measurement by the end of the data collection in July 1995. Follow-up was incomplete in more than 70 percent of children. Nineteen children (19 percent) with initially abnormal lead concentrations had follow-up testing with persistently normal results. The yearly cost of follow-up was $15,888, with only 7 children requiring county health environmental intervention. The nurse-centered, computer-aided system improved follow-up care of children with abnormal lead concentrations, but most patients still did not receive mandated follow-up testing because of logistic obstacles. The effort and cost associated with CDC-mandated follow-up of children with lead concentrations between 10 and 19 micrograms/dL provides no apparent benefit and might detract from the care of children at higher risk.

  15. Update on Kramers-Kronig relation for proton

    Energy Technology Data Exchange (ETDEWEB)

    Gryniuk, Oleksii [JGU, Mainz (Germany); KNU, Kyiv (Ukraine); Hagelstein, Franziska; Pascalutsa, Vladimir [JGU, Mainz (Germany)

    2015-07-01

    New evaluation of the Baldin sum rule and forward Compton scattering amplitude, as well as higher order sum rules, was made with updated data for proton total photoabsorption cross-section. Stability of resulting values, comparison to previous evaluations and consequences of results for higher order sum rules are discussed.

  16. Evaluation Results From Prospective Drug Utilization Review: Medicaid Demonstrations

    OpenAIRE

    Kidder, David; Bae, Jay

    1999-01-01

    In 1992 HCFA awarded two cooperative agreements for demonstrations of prospective drug utilization review (PDUR). Iowa tested an on-line prospective drug utilization review (OPDUR) system. Washington tested payments to pharmacists for providing non-dispensing “cognitive services” (CS). In this article the authors report on an evaluation of these demonstrations and on three assessments of retrospective drug utilization review (RDUR) interventions. The evaluation failed to detect effects of eit...

  17. Status Update

    Science.gov (United States)

    Hernandez, Arelis

    2010-01-01

    This article offers some updates on the share of the higher education institutions in the billion-worth stimulus package and how institutions were assisted through this funding. Since the $787 billion stimulus package, formally known as the American Reinvestment and Recovery Act (ARRA), was signed into law in 2009, an estimated $50 billion to $75…

  18. Climate change and human health impacts in the United States: an update on the results of the U.S. national assessment.

    Science.gov (United States)

    Ebi, Kristie L; Mills, David M; Smith, Joel B; Grambsch, Anne

    2006-09-01

    The health sector component of the first U.S. National Assessment, published in 2000, synthesized the anticipated health impacts of climate variability and change for five categories of health outcomes: impacts attributable to temperature, extreme weather events (e.g., storms and floods) , air pollution, water- and food-borne diseases, and vector- and rodent-borne diseases. The Health Sector Assessment (HSA) concluded that climate variability and change are likely to increase morbidity and mortality risks for several climate-sensitive health outcomes, with the net impact uncertain. The objective of this study was to update the first HSA based on recent publications that address the potential impacts of climate variability and change in the United States for the five health outcome categories. The literature published since the first HSA supports the initial conclusions, with new data refining quantitative exposure-response relationships for several health end points, particularly for extreme heat events and air pollution. The United States continues to have a very high capacity to plan for and respond to climate change, although relatively little progress has been noted in the literature on implementing adaptive strategies and measures. Large knowledge gaps remain, resulting in a substantial need for additional research to improve our understanding of how weather and climate, both directly and indirectly, can influence human health. Filling these knowledge gaps will help better define the potential health impacts of climate change and identify specific public health adaptations to increase resilience.

  19. Summary of November 2010 meeting to evaluate turbidite data for constraining the recurrence parameters of great Cascadia earthquakes for the update of national seismic hazard maps

    Science.gov (United States)

    Frankel, Arthur D.

    2011-01-01

    This report summarizes a meeting of geologists, marine sedimentologists, geophysicists, and seismologists that was held on November 18–19, 2010 at Oregon State University in Corvallis, Oregon. The overall goal of the meeting was to evaluate observations of turbidite deposits to provide constraints on the recurrence time and rupture extent of great Cascadia subduction zone (CSZ) earthquakes for the next update of the U.S. national seismic hazard maps (NSHM). The meeting was convened at Oregon State University because this is the major center for collecting and evaluating turbidite evidence of great Cascadia earthquakes by Chris Goldfinger and his colleagues. We especially wanted the participants to see some of the numerous deep sea cores this group has collected that contain the turbidite deposits. Great earthquakes on the CSZ pose a major tsunami, ground-shaking, and ground-failure hazard to the Pacific Northwest. Figure 1 shows a map of the Pacific Northwest with a model for the rupture zone of a moment magnitude Mw 9.0 earthquake on the CSZ and the ground shaking intensity (in ShakeMap format) expected from such an earthquake, based on empirical ground-motion prediction equations. The damaging effects of such an earthquake would occur over a wide swath of the Pacific Northwest and an accompanying tsunami would likely cause devastation along the Pacifc Northwest coast and possibly cause damage and loss of life in other areas of the Pacific. A magnitude 8 earthquake on the CSZ would cause damaging ground shaking and ground failure over a substantial area and could also generate a destructive tsunami. The recent tragic occurrence of the 2011 Mw 9.0 Tohoku-Oki, Japan, earthquake highlights the importance of having accurate estimates of the recurrence times and magnitudes of great earthquakes on subduction zones. For the U.S. national seismic hazard maps, estimating the hazard from the Cascadia subduction zone has been based on coastal paleoseismic evidence of great

  20. Results of evaluation of tailing dumps dust intensity

    OpenAIRE

    Masloboev V. A.; Baklanov A. A.; Amosov P. V.

    2016-01-01

    A set of most acceptable and well-known methods of dust intensity evaluation has been defined and tested (dependence of Westphal D. L. et al. and DEAD scheme) based on the analysis of exiting approaches (deserts, tailing dumps, etc.). The description of the chosen methods has been given. The determination of dynamic velocity u* and velocity at the height of +10 m above the dusting surface u10 which are necessary to evaluate the dust intensity has been demonstrated. The method is based on two-...

  1. Thyroid dysfunction during pregnancy and evaluation of its results

    OpenAIRE

    Bostancı, Mehmet Sühha; Taşkesen, Fatih

    2011-01-01

    S Objectives: In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women. Materials and methods: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH), free tri-iyodotironin (T3), free thyroxine (T4) levels for all patients were stud...

  2. Thyroid dysfunction during pregnancy and evaluation of its results

    OpenAIRE

    Fatih Taşkesen; Mehmet Sühha Bostancı

    2011-01-01

    In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women.Materials and methos: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH), free tri-iyodotironin (T3), free thyroxine (T4) levels for all patients were studied. Antithyroidal per...

  3. 10 CFR 709.15 - Processing counterintelligence evaluation results.

    Science.gov (United States)

    2010-01-01

    ... financial, credit, travel, and other relevant information to resolve any identified issues. Participation by Office of Intelligence and Counterintelligence personnel in any such evaluation is subject to Executive Order 12333, the DOE “Procedures for Intelligence Activities,” and other relevant laws, guidelines, and...

  4. [Update of recommendations for evaluation and treatment of osteoporosis associated to endocrine and nutritional conditions. Working Group on Osteoporosis and Mineral Metabolism of the Spanish Society of Endocrinology].

    Science.gov (United States)

    Reyes-García, Rebeca; García-Martín, Antonia; Varsavsky, Mariela; Rozas-Moreno, Pedro; Cortés-Berdonces, María; Luque-Fernández, Inés; Gómez Sáez, José Manuel; Vidal Casariego, Alfonso; Romero Muñoz, Manuel; Guadalix Iglesias, Sonsoles; Fernández García, Diego; Jódar Gimeno, Esteban; Muñoz Torres, Manuel

    2015-05-01

    To update previous recommendations developed by the Working Group on Osteoporosis and Mineral Metabolism of the Spanish Society of Endocrinology and Nutrition for the evaluation and treatment of osteoporosis associated to different endocrine and nutritional diseases. Members of the Working Group on Osteoporosis and Mineral Metabolism of the Spanish Society of Endocrinology and Nutrition. Recommendations were formulated according to the GRADE system (Grading of Recommendations, Assessment, Development, and Evaluation) to describe both the strength of recommendations and the quality of evidence. A systematic search was made in MEDLINE (Pubmed) using the following terms associated to the name of each condition: AND "osteoporosis", "fractures", "bone mineral density", and "treatment". Papers in English with publication date between 18 October 2011 and 30 October 2014 were included. The recommendations were discussed and approved by all members of the Working Group. This update summarizes the new data regarding evaluation and treatment of osteoporosis associated to endocrine and nutritional conditions. Copyright © 2015 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

  5. Evaluation results of using sole Ilizarov fixator in Pilon fractures

    Directory of Open Access Journals (Sweden)

    Ahmad Reza Mirbolook

    2014-02-01

    Conclusion: According to the results obtained and comparing them with the results of other treatments ,one can claim that this treating approach is better than the others for pilon fractures,particularly for type 3c pilon fractures.

  6. Ultrasound Risk Categories for Thyroid Nodules and Cytology Results: A Single Institution’s Experience after the Adoption of the 2016 Update of Medical Guidelines by the American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi

    Directory of Open Access Journals (Sweden)

    Roberto Negro

    2017-01-01

    Full Text Available Objectives. In 2016, the American Association of Clinical Endocrinologists (AACE and Associazione Medici Endocrinologi (AME released updated guidelines for the diagnosis and management of thyroid nodules. The aim of this study was to evaluate the AACE/AME recommendations for FNA in clinical practice, by comparing the (US stratification risk and indications for FNA with cytologic results. Methods. From May to December 2016, we collected the cytologic results from FNAs of nodules that were classified using a three-tier US category system (low, intermediate, and high risk. Results. We obtained 859 FNAs from 598 patients: 341 (39.7% from low, 489 (56.9% from intermediate, and 29 (3.4% from high risk nodules. Of these, 88.5% and 74.9% of low and intermediate risk nodules, respectively, were cytologically benign, whereas 84.6% of high risk nodules had a moderate-to-elevated risk of malignancy or were malignant. If FNAs had been limited to intermediate risk nodules >20 mm, we would have missed 13/17 (76.5% nodules that had moderate-to-elevated risk of malignancy or were malignant (11/13 were malignant based on histology. Conclusions. A nonnegligible number of cytologically malignant nodules or nodules that were suspected to be malignant would be missed if intermediate US risk nodules <20 mm were not biopsied.

  7. Psychological Evaluation Results in Patients Confronted with Sexual Abuse

    OpenAIRE

    Işık Karakaya; Ayşen Coşkun; Belma Ağaoğlu; Şahika Gülen Şişmanlar; Özlem Yıldız Öç; Nursu Çakın Memik; Ümit Biçer

    2006-01-01

    Child and adolescent sexual abuse have lifelong consequences. Sexual development, emotional effects, depressed mood, anxiety, behavioral effects and alteration of personality are some possible consequences of sexual abuse. In this article we evaluated psychiatric symptoms according to DSM-IV diagnostic criteria in 21 sexually abused children and adolescents. Twelve girls and nine boys between 4 and 16 years of age were investigated. All the patients belonged to low socioeconomic strata. The m...

  8. Evaluating participatory research: Framework, methods and implementation results.

    Science.gov (United States)

    Smajgl, Alex; Ward, John

    2015-07-01

    This paper describes a structured participatory process and associated evaluation protocol developed to detect systems learning by decision makers involved in the management of natural resources. A series of facilitated participatory workshops were conducted to investigate learning when decision makers and influencers were confronted with the multiple, complex interactions arising from decisions concerned with the nexus of water, food and energy security. The participatory process and evaluation of learning were trialled in the Greater Mekong Subregion (GMS), where integrated scientific evidence was systematically presented to challenge existing beliefs concerned with the effectiveness of proposed policy actions and development investments. Consistent with theoretical propositions, individually held values, beliefs and attitudes were deployed as the primary factors (and psychometrics) that underpin and influence environmental management decision making. Observed and statistically significant changes in the three psychometrics expressed by decision makers in response to the facilitated presentation of scientific evidence during the participatory process, provided supportive evidence of systems learning and the evaluation protocol. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  9. Interdisciplinary consensus on diagnosis and treatment of testicular germ cell tumors. Results of an update conference based on evidence-based medicine (EBM); Interdisziplinaerer Konsensus zur Diagnostik und Therapie von Hodentumoren. Ergebnisse einer Update-Konferenz auf Grundlage evidenzbasierter Medizin (EBM)

    Energy Technology Data Exchange (ETDEWEB)

    Souchon, R. [Deutsche Gesellschaft fuer Radioonkologie (DEGRO) (Germany); Arbeitsgemeinschaft Radiologische Onkologie (ARO), Strahlenklinik AKH Hagen (Germany); Krege, S. [Deutsche Gesellschaft fuer Urologie (DGU) (Germany); Essen Univ. (Gesamthochschule) (Germany). Klinik und Poliklinik fuer Urologie; Schmoll, H.J. [Arbeitsgemeinschaft Internistische Onkologie (AIO), Zentrum fuer innere Medizin IV der Martin-Luther-Univ. Halle-Wittenberg (Germany); Albers, P. [Bonn Univ. (Germany). Urologische Klinik; Beyer, J. [Marburg Univ. (Germany). Medizinisches Zentrum fuer Innere Medizin; Bokemeyer, C. [Tuebingen Univ. (Germany). Abt. fuer Innere Medizin 2; Classen, J. [Tuebingen Univ. (Germany). Medizinisches Strahleninstitut und Roentgenabteilung; Dieckmann, K.P. [Albertinen-Krankenhaus, Hamburg (Germany). Urologische Abt.; Hartmann, M. [Bundeswehrkrankenhaus, Hamburg (Germany). Urologische Abt.; Heidenreich, A. [Marburg Univ. (Germany). Urologische Klinik; Hoeltl, W. [Kaiser-Franz-Josef-Spital Wien (Austria). Urologische Klinik; Kliesch, S. [Muenster Univ. (Germany). Klinik fuer Urologie; Koehrmann, K.U. [Urologische Klinik des Klinikums der Stadt Mannheim (Germany); Kuczyk, M. [Medizinische Hochschule Hannover (Germany). Klinik fuer Urologie; Schmidberger, H. [Goettingen Univ. (Germany). Klinik fuer Strahlentherapie und Radioonkologie; Weinknecht, S. [Krankenhaus am Urban Berlin (Germany). Urologische Abt.; Winter, E. [Klinikum Schwerin (Germany). Urologische Klinik; Wittekind, C. [Leipzig Univ. (Germany). Inst. fuer Pathologie; Bamberg, M. [Tuebingen Univ. (Germany). Abt. fuer Strahlentherapie

    2000-09-01

    An 'Interdisciplinary Update Consensus Statement' summarizes and defines the diagnostic and therapeutic standards according to the current scientific practices in testicular cancer. For 21 separate areas scientifically based decision criteria are suggested. For treatment areas where more than one option exist without a consensus being reached for a preferred strategy, such as in seminoma in clinical Stage I or in non-seminoma Stages CS I or CS IIA/B, all acceptable alternative strategies with their respecitve advantages and disadvantages are presented. This 'Interdisciplinary Update Consensus' was presented at the 24th National Congress of the German Cancer Society on March 21st and subsequently evaluated and approved by the various German scientific medical societies. (orig.) [German] Der zu 21 Themenkomplexen anhand wissenschaftlich begruendeter Entscheidungskriterien erarbeitete 'Interdisziplinaere Update-Konsensus' praezisiert und definiert diagnostische und therapeutische Standards entsprechend dem aktuellen Wissensstand ueber die Tumorentitaet. Fuer Therapiesituationen, bei denen mehrere Optionen bestehen und kein Konsens ueber die favorisierte Strategie erzielt wurde wie beim Seminom im klinischen Stadium I oder beim Nichtseminom in den Stadien CS I bzw. CS IIA/B, wurden jeweilige Alternativen mit deren Vor- und Nachteilen dargestellt. Der 'Interdisziplinaere Update-Konsensus' wurde beim 24. Deutschen Krebskongress am 21.3.2000 vorgestellt, nachfolgend von den daran beteiligten wissenschaftlichen Fachgesellschaften geprueft und gebilligt. (orig.)

  10. Learning results and evaluation through levels given by the results in Religious Education

    Directory of Open Access Journals (Sweden)

    Emil Lazar

    2016-05-01

    Full Text Available Multilevel approach to religious education assessment entails rethinking the evaluative approach, starting from the systemic perspective on the evaluation object to religion, like regulatory reporting, to curriculum and who materialized from inductive perspective, in terms of subject assessment, the entire complexity of the student. The Assessment Tool that we proposed is an integrative one, an opportunity to see the process, be aware of the process by which it is evaluated and develop the ability to track what is happening in this process and intervene for the evaluator. It is about a formative assessment, as long as the proposed instrument "crosses the boundaries of various learning activities". As a school discipline, Religion is integrative one (contributing, complementing the student's general education and integrator (harmonizing the various skills of the student's academic in progress tracked throughout the student's education unit. Religious education provides and contributes to personal development of students and (self empowering their formation process, exceeding the borders of a single discipline and ensuring premises skills training trans-disciplinary on the basis of specific skills, necessary for personal development of the student. Finally, this idea of approaching religion as a subject from the perspective of education for values is very interesting and debated.

  11. Evaluation of the sanitary impact of urban air pollution. Update version of the methodological guide; Evaluation de l'impact sanitaire de la pollution atmospherique urbaine. Version actualisee du guide methodologique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-15

    In order to bring a help to the evaluation of effects of air quality on health, the Institute of Sanitary surveillance published in 1999 a method guide for the realisation of sanitary impact evaluations of the urban air pollution. This work to prepare to an update version of the guide presents the first recommendations that can be made today for the realisation of sanitary impact evaluations at short and long term at a local level, taking into account the knowledge evolution. (N.C.)

  12. Long-term results of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study.

    Science.gov (United States)

    Jingu, Keiichi; Matsushita, Haruo; Takeda, Ken; Umezawa, Rei; Takahashi, Chiaki; Sugawara, Toshiyuki; Kubozono, Masaki; Abe, Keiko; Tanabe, Takaya; Shirata, Yuko; Yamamoto, Takaya; Ishikawa, Youjirou; Nemoto, Kenji

    2012-11-22

    In 2006, we reported the effectiveness of chemoradiotherapy for postoperative recurrent esophageal cancer with a median observation period of 18 months. The purpose of the present study was to update the results of radiotherapy combined with nedaplatin and 5-fluorouracil (5-FU) for postoperative loco-regional recurrent esophageal cancer. Between 2000 and 2004, we performed a phase II study on treatment of postoperative loco-regional recurrent esophageal cancer with radiotherapy (60 Gy/30 fractions/6 weeks) combined with chemotherapy consisting of two cycles of nedaplatin (70 mg/m2/2 h) and 5-FU (500 mg/m2/24 h for 5 days).The primary endpoint was overall survival rate, and the secondary endpoints were progression-free survival rate, irradiated-field control rate and chronic toxicity. A total of 30 patients were enrolled in this study. The regimen was completed in 76.7% of the patients. The median observation period for survivors was 72.0 months. The 5-year overall survival rate was 27.0% with a median survival period of 21.0 months. The 5-year progression-free survival rate and irradiated-field control rate were 25.1% and 71.5%, respectively. Grade 3 or higher late toxicity was observed in only one patient. Two long-term survivors had gastric tube cancer more than 5 years after chemoradiotherapy.Pretreatment performance status, pattern of recurrence (worse for patients with anastomotic recurrence) and number of recurrent lesions (worse for patients with multiple recurrent lesions) were statistically significant prognostic factors for overall survival. Radiotherapy combined with nedaplatin and 5-FU is a safe and effective salvage treatment for postoperative loco-regional recurrent esophageal cancer. However, the prognosis of patients with multiple regional recurrence or anastomotic recurrence is very poor.

  13. Ultrasound Risk Categories for Thyroid Nodules and Cytology Results: A Single Institution's Experience after the Adoption of the 2016 Update of Medical Guidelines by the American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi.

    Science.gov (United States)

    Negro, Roberto; Greco, Gabriele; Colosimo, Ermenegildo

    2017-01-01

    In 2016, the American Association of Clinical Endocrinologists (AACE) and Associazione Medici Endocrinologi (AME) released updated guidelines for the diagnosis and management of thyroid nodules. The aim of this study was to evaluate the AACE/AME recommendations for FNA in clinical practice, by comparing the (US) stratification risk and indications for FNA with cytologic results. From May to December 2016, we collected the cytologic results from FNAs of nodules that were classified using a three-tier US category system (low, intermediate, and high risk). We obtained 859 FNAs from 598 patients: 341 (39.7%) from low, 489 (56.9%) from intermediate, and 29 (3.4%) from high risk nodules. Of these, 88.5% and 74.9% of low and intermediate risk nodules, respectively, were cytologically benign, whereas 84.6% of high risk nodules had a moderate-to-elevated risk of malignancy or were malignant. If FNAs had been limited to intermediate risk nodules >20 mm, we would have missed 13/17 (76.5%) nodules that had moderate-to-elevated risk of malignancy or were malignant (11/13 were malignant based on histology). A nonnegligible number of cytologically malignant nodules or nodules that were suspected to be malignant would be missed if intermediate US risk nodules <20 mm were not biopsied.

  14. The DONE framework: Creation, evaluation, and updating of an interdisciplinary, dynamic framework 2.0 of determinants of nutrition and eating.

    Science.gov (United States)

    Stok, F Marijn; Hoffmann, Stefan; Volkert, Dorothee; Boeing, Heiner; Ensenauer, Regina; Stelmach-Mardas, Marta; Kiesswetter, Eva; Weber, Alisa; Rohm, Harald; Lien, Nanna; Brug, Johannes; Holdsworth, Michelle; Renner, Britta

    2017-01-01

    The question of which factors drive human eating and nutrition is a key issue in many branches of science. We describe the creation, evaluation, and updating of an interdisciplinary, interactive, and evolving "framework 2.0" of Determinants Of Nutrition and Eating (DONE). The DONE framework was created by an interdisciplinary workgroup in a multiphase, multimethod process. Modifiability, relationship strength, and population-level effect of the determinants were rated to identify areas of priority for research and interventions. External experts positively evaluated the usefulness, comprehensiveness, and quality of the DONE framework. An approach to continue updating the framework with the help of experts was piloted. The DONE framework can be freely accessed (http://uni-konstanz.de/DONE) and used in a highly flexible manner: determinants can be sorted, filtered and visualized for both very specific research questions as well as more general queries. The dynamic nature of the framework allows it to evolve as experts can continually add new determinants and ratings. We anticipate this framework will be useful for research prioritization and intervention development.

  15. Psychological Evaluation Results in Patients Confronted with Sexual Abuse

    Directory of Open Access Journals (Sweden)

    Işık Karakaya

    2006-08-01

    Full Text Available Child and adolescent sexual abuse have lifelong consequences. Sexual development, emotional effects, depressed mood, anxiety, behavioral effects and alteration of personality are some possible consequences of sexual abuse. In this article we evaluated psychiatric symptoms according to DSM-IV diagnostic criteria in 21 sexually abused children and adolescents. Twelve girls and nine boys between 4 and 16 years of age were investigated. All the patients belonged to low socioeconomic strata. The most frequently diagnosed psychiatric disorders in these children were posttraumatic stress disorder, separation anxiety disorder, major depressive disorder and elimination disorder. Sexually abused children and adolescents present various psychiatric symptoms. So, understanding the consequences of sexual abuse on children and adolescents is significant in assessment, prevention, and treatment. Key words: Child, adolescent, sexual abuse, psychiatric effects

  16. MICROBIOLOGICAL EVALUATION OF WATER BUFFALO COLOSTRUM: FIRST RESULTS

    Directory of Open Access Journals (Sweden)

    P. Catellani

    2012-08-01

    Full Text Available Animal colostrum contains many substances with antibacterial activity such as lysozyme and lactoferrin which should inhibit the microbial growth. The aim of this research is to understand if colostrum can be considered a safe product, considering that Regulation (EC N° 1662/2006, which has modified the Regulation (EC N° 853/2004, introducing colostrum as human food. Microbiological tests, made on water buffalo colostrum, aiming to obtain the total microbial count (maximum concentration: 3,6•104 ufc/ml, the quantitative evaluation of total (maximum the highest concentration found: 2,3•103 ufc/ml and fecal coliforms (maximum concentration: 4,9•102 ufc/ml and the qualitative search of Salmonella spp. and Listeria monocytogenes, showed that there is not a microbial growth in colostrum, that it can be considered a safe food, from the microbial point of view

  17. [LAPTOP trial--results of an health economics evaluation].

    Science.gov (United States)

    Dippel, F-W

    2008-08-01

    Based on the LAPTOP trial, a cost and a benefit assessment were undertaken. The cost analysis was performed as a desk-top evaluation using the cost minimization method. The benefit assessment was done as a simulation using the diabetes mellitus model (DMM). In each analysis either cost or benefit of treating diabetes mellitus with oral antidiabetic drug(s) supported by insulin glargine were compared to those with conventional insulin treatment using premixed insulin twice daily. The cost benefit analysis demonstrated that treatment with insulin glargine plus oral antidiabetics was less expensive than the conventional insulin treatment with premixed insulin. Furthermore, avoidance of diabetic complications was better with insulin glargine plus oral antidiabetics than with premixed insulin alone.

  18. Soil compaction: Evaluation of stress transmission and resulting soil structure

    DEFF Research Database (Denmark)

    Naveed, Muhammad; Schjønning, Per; Keller, Thomas

    Accurate estimation of stress transmission and resultant deformation in soil profiles is a prerequisite for the development of predictive models and decision support tools for preventing soil compaction. Numerous studies have been carried out on the effects of soil compaction, whilst relatively few...... and compaction-resulted soil structure at the same time. Stress transmission was quantified using both X-ray CT and Tactilus sensor mat, and soil-pore structure was quantified using X-ray CT. Our results imply that stress transmission through soil highly depends on the magnitude of applied load and aggregate...... studies have focused on the cause (mode of stress transmission in the soil). We have coupled both cause and effects together in the present study by carrying out partially confined compression tests on (1) wet aggregates, (2) air dry aggregates, and (3) intact soils to quantify stress transmission...

  19. Evaluation of antiretroviral therapy results in Blantyre, Malawi | van ...

    African Journals Online (AJOL)

    The most common side effect was peripheral neuropathy. Nevirapine plasma levels were remarkably high and associated with successful virological treatment results. Two simple adherence questions pertaining to the use of medication in the previous 8 days corresponded well with nevirapine levels. The most important ...

  20. Soil compaction: Evaluation of stress transmission and resulting soil structure

    Science.gov (United States)

    Naveed, Muhammad; Schjønning, Per; Keller, Thomas; Lamande, Mathieu

    2016-04-01

    Accurate estimation of stress transmission and resultant deformation in soil profiles is a prerequisite for the development of predictive models and decision support tools for preventing soil compaction. Numerous studies have been carried out on the effects of soil compaction, whilst relatively few studies have focused on the cause (mode of stress transmission in the soil). We have coupled both cause and effects together in the present study by carrying out partially confined compression tests on (1) wet aggregates, (2) air dry aggregates, and (3) intact soils to quantify stress transmission and compaction-resulted soil structure at the same time. Stress transmission was quantified using both X-ray CT and Tactilus sensor mat, and soil-pore structure was quantified using X-ray CT. Our results imply that stress transmission through soil highly depends on the magnitude of applied load and aggregate strength. As soon as the applied load is lower than the aggregate strength, the mode of stress transmission is discrete as stresses were mainly transmitted through chain of aggregates. With increasing applied load soil aggregates start deforming that transformed heterogeneous soil into homogenous, as a result stress transmission mode was shifted from discrete towards more like a continuum. Continuum-like stress transmission mode was better simulated with Boussinesq (1885) model based on theory of elasticity compared to discrete. The soil-pore structure was greatly affected by increasing applied stresses. Total porosity was reduced 5-16% and macroporosity 50-85% at 620 kPa applied stress for the intact soils. Similarly, significant changes in the morphological indices of the macropore space were also observed with increasing applied stresses.

  1. [Hearing screening at nursery schools: results of an evaluation study].

    Science.gov (United States)

    Weichbold, Viktor; Rohrer, Monika; Winkler, Cornelia; Welzl-Müller, Kunigunde

    2004-07-31

    This study aimed to evaluate the hearing screening of pre-school children at nursery schools in Tyrol, Austria. 47 nursery schools with a total of 2199 enrolled children participated in the study. At the screening, the children were presented a series of tones at frequencies 0.5 kHz (25dB), 1 kHz, 2 kHz, 3 kHz, and 4 kHz (20 dB each) from portable audiometers. The tones were presented over headphones for each ear separately and at irregular intervals. Failure to respond to any of the frequencies was considered failure of the screening. Parents were then advised in written form to have the child examined by an ENT-specialist. 1832 individuals were screened (coverage: 83% of nursery school children; corresponding to at least 63% of all Tyrolean children aged 3 to 5 years). Of these, 390 failed the test (referral rate: 21% of all screened). Examination through an ENT-specialist occurred with 217 children, and this confirmed the positive test in 139 children (hit rate: 64%). In most cases, a temporary conductive hearing loss due to external or middle ear problems (glue ear, tube dysfunction, cerumen, otitis media) was diagnosed. A sensorineural hearing loss was found in 4 children (in 3 of them bilateral). The need for therapy was recognized in 81 children (4% of all screened). Pre-school hearing screening identifies children with ear and hearing problems that need therapeutical intervention. Although the hearing problems are mostly of a temporary nature, some may require monitoring over some period. Also some children with permanent sensorineural hearing loss may be detected through this measure. Hearing screening is an efficient means of assessing ear and hearing problems in pre-school children. However, the follow-up rate needs to be improved for optimizing the efficacy.

  2. Evaluating EU Regional Policy: Many Empirical Specifications, One (Unpleasant) Result

    DEFF Research Database (Denmark)

    Breidenbach, Philipp; Mitze, Timo; Schmidt, Christoph

    Numerous studies have focused on the role of EU regional policy in fostering growth and convergence among European regions, why conducting another one? We argue that two facts are still lacking in the actual academic debate in order to get a sound empirical identification strategy and reliable...... results: First, one should take the theoretical underpinnings of regional growth models more serious, and second, a likewise careful account of the role of spatial dependence in the underlying data is needed. Though research has increasingly become aware of the latter point as important control factor...

  3. Association of GST genetic polymorphisms with the susceptibility to hepatocellular carcinoma (HCC in Chinese population evaluated by an updated systematic meta-analysis.

    Directory of Open Access Journals (Sweden)

    Kui Liu

    Full Text Available BACKGROUND: Due to the possible involvement of Glutathione S-transferase Mu-1 (GSTM1 and Glutathione S-transferase theta-1 (GSTT1 in the detoxification of environmental carcinogens, environmental toxins, and oxidative stress products, genetic polymorphisms of these two genes may play important roles in the susceptibility of human being to hepatocellular carcinoma. However, the existing research results are not conclusive. METHODS: A systematic literature search using databases (PubMed, Scopus, Embase, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wanfang Data, etc. for the eligible studies meeting the inclusion criteria including case-control studies or cohort studies is evaluated using an updated systematic meta-analysis. RESULTS: Significant increase in the risk of HCC in the Chinese population is found in GSTM1 null genotype (OR = 1.47, 95% CI: 1.21 to 1.79, P<0.001 and GSTT1 null genotype (OR = 1.38, 95% CI: 1.14 to 1.65, P<0.001. Analysis using the random-effects model found an increased risk of HCC in GSTM1-GSTT1 dual null population (OR = 1.79, 95% CI: 1.26 to 2.53, P<0.001. In addition, subgroup analyses showed a significant increase in the association of GST genetic polymorphisms (GSTM1, GSTT1, and GSTM1-GSTT1 with HCC in southeast and central China mainland. However, available data collected by this study fail to show an association between GST genetic polymorphisms and HCC in people from the Taiwan region (for GSTM1: OR = 0.78, 95% CI: 0.60 to 1.01, P = 0.06; for GSTT1: OR = 0.94, 95% CI: 0.78 to 1.14, P = 0.546; for GSTM1-GSTT1: OR = 1.04, 95% CI: 0.81 to 1.32, P = 0.77. Sensitivity analysis and publication bias diagnostics confirmed the reliability and stability of this meta-analysis. CONCLUSIONS: Our results indicate that both GSTM1 and GSTT1 null genotypes are associated with an increased HCC risk in Chinese population. Peoples with dual null genotypes of GSTM1-GSTT1

  4. SULFURIC ACID REMOVAL PROCESS EVALUATION: SHORT-TERM RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Gary M. Blythe; Richard McMillan

    2002-03-04

    results of the short-term tests; the long-term test results will be reported in a later document. The short-term test results showed that three of the four reagents tested, dolomite powder, commercial magnesium hydroxide slurry, and byproduct magnesium hydroxide slurry, were able to achieve 90% or greater removal of sulfuric acid compared to baseline levels. The molar ratio of alkali to flue gas sulfuric acid content (under baseline conditions) required to achieve 90% sulfuric acid removal was lowest for the byproduct magnesium hydroxide slurry. However, this result may be confounded because this was the only one of the three slurries tested with injection near the top of the furnace across from the pendant superheater platens. Injection at the higher level was demonstrated to be advantageous for this reagent over injection lower in the furnace, where the other slurries were tested.

  5. SULFURIC ACID REMOVAL PROCESS EVALUATION: SHORT-TERM RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Gary M. Blythe; Richard McMillan

    2002-02-04

    the results of the short-term tests; the long-term test results will be reported in a later document. The short-term test results showed that three of the four reagents tested, dolomite powder, commercial magnesium hydroxide slurry, and byproduct magnesium hydroxide slurry, were able to achieve 90% or greater removal of sulfuric acid compared to baseline levels. The molar ratio of alkali to flue gas sulfuric acid content (under baseline conditions) required to achieve 90% sulfuric acid removal was lowest for the byproduct magnesium hydroxide slurry. However, this result may be confounded because this was the only one of the three slurries tested with injection near the top of the furnace across from the pendant superheater platens. Injection at the higher level was demonstrated to be advantageous for this reagent over injection lower in the furnace, where the other slurries were tested.

  6. Preliminary results on scintigraphic evaluation of malignant external otitis

    Energy Technology Data Exchange (ETDEWEB)

    Malamitsi, J.; Maragoudakis, P. (Hippocrateion Hospital, Athens (Greece). Dept. of Nuclear Medicine); Papafragou, K.; Koukouliou, V. (Athens Univ. (Greece). Dept. of Medical Physics); Kalatzis, Y.; Adamopoulos, G.; Proukakis, C. (Hippocrateion Hospital, Athens (Greece). ORL Univ. Clinic)

    1993-06-01

    Malignant external otitis (MEO) is a potentially fatal otitis occurring in diabetic and immunosuppressed patients, which may cause cranial nerve palsies and massive thrombophlebitis of the brain. We studied five diabetic patients with the clinical diagnosis of external otitis who were suspected of having MEO and one diabetic patient presumed cured from MEO. All of them underwent methylene diphosphonate, nanocolloid and gallium single-photon emission tomography studies with quantitative analysis on the basis of regions of interest and count profile curves. This combined assessment helped us to diagnose and follow-up soft tissue and temporal bone infection, especially in the case of transsphenoidal extension of the disease, since conventional radiology and computed tomography were of no particular help. On the basis of these results, we consider scintigraphic demonstration of skull base infection as a fourth criterion of MEO given that the classical Chandler's triad (diabetes, granuloma, and Pseudomonas aeruginosa) is not always present. (orig.).

  7. Maintenance treatment with capecitabine and bevacizumab versus observation in metastatic colorectal cancer: updated results and molecular subgroup analyses of the phase 3 CAIRO3 study.

    Science.gov (United States)

    Goey, K K H; Elias, S G; van Tinteren, H; Laclé, M M; Willems, S M; Offerhaus, G J A; de Leng, W W J; Strengman, E; Ten Tije, A J; Creemers, G-J M; van der Velden, A; de Jongh, F E; Erdkamp, F L G; Tanis, B C; Punt, C J A; Koopman, M

    2017-09-01

    The phase 3 CAIRO3 study showed that capecitabine plus bevacizumab (CAP-B) maintenance treatment after six cycles capecitabine, oxaliplatin, and bevacizumab (CAPOX-B) in metastatic colorectal cancer (mCRC) patients is effective, without compromising quality of life. In this post hoc analysis with updated follow-up and data regarding sidedness, we defined subgroups according to RAS/BRAF mutation status and mismatch repair (MMR) status, and investigated their influence on treatment efficacy. A total of 558 patients with previously untreated mCRC and stable disease or better after six cycles CAPOX-B induction treatment were randomised to either CAP-B maintenance treatment (n = 279) or observation (n = 279). Upon first progression, patients were to receive CAPOX-B reintroduction until second progression (PFS2, primary end point). We centrally assessed RAS/BRAF mutation status and MMR status, or used local results if central assessment was not possible. Intention-to-treat stratified Cox models adjusted for baseline covariables were used to examine whether treatment efficacy was modified by RAS/BRAF mutation status. RAS, BRAF mutations, and MMR deficiency were detected in 240/420 (58%), 36/381 (9%), and 4/279 (1%) patients, respectively. At a median follow-up of 87 months (IQR 69-97), all mutational subgroups showed significant improvement from maintenance treatment for the primary end point PFS2 [RAS/BRAF wild-type: hazard ratio (HR) 0.57 (95% CI 0.39-0.84); RAS-mutant: HR 0.74 (0.55-0.98); V600EBRAF-mutant: HR 0.28 (0.12-0.64)] and secondary end points, except for the RAS-mutant subgroup regarding overall survival. Adjustment for sidedness instead of primary tumour location yielded comparable results. Although right-sided tumours were associated with inferior prognosis, both patients with right- and left-sided tumours showed significant benefit from maintenance treatment. CAP-B maintenance treatment after six cycles CAPOX-B is effective in first

  8. Evaluating Surface Flux Results from CERES-FLASHFlux

    Science.gov (United States)

    Wilber, A. C.; Stackhouse, P. W., Jr.; Kratz, D. P.; Gupta, S. K.; Sawaengphokhai, P.

    2016-12-01

    The Clouds and Earth's Radiant Energy System (CERES) mission provides TOA (Top-of-Atmosphere) and surface radiative flux products for each CERES footprint (Single Scanner Footprint) and also time integrated and spatially averaged (TISA) to provide 1ox1o fluxes at various temporal averages. The CERES TISA products are available to the public within 3-6 months of observation. The CERES Fast Longwave and SHortwave radiative Flux (FLASHFlux) data products were developed to provide a rapid release version of the CERES data products. FLASHFlux data products are made available to the research and applications communities within one week of the satellite observations. Over the last several years, the CERES team has contributed to a section on the variability of radiation budget at the Top-of-Atmosphere in the annual "State of the Climate Report" published in BAMS using CERES TISA and FLASHFlux data products. Recently, the FLASHFlux data were used to investigate the radiative impacts of the intense 2015-2016 El Nino event. In addition FLASHFlux date are routinely used by applied science in energy related and agricultural sectors. The current version of FLASHFlux is being upgraded to FLASHFlux Version4A to improve consistency with the climate quality Edition 4 CERES data products. This presentation will describe the planned changes including the change to the latest meteorological product from Global Modeling and Assimilation Office (GMAO), GEOS FP-IT (5.12.4). GEOS 5.12.4 is an assimilation that is consistent with MERRA-2. We present comparisons of global and regional changes in the TOA and surface radiative fluxes as a result of the upgrade for both longwave (LW) and shortwave (SW) surface fluxes. We also compare the data products against ground measurements using data from the Baseline Surface Radiation Network (BSRN) - including NOAA SURFRAD, Atmospheric Radiation Measurement (ARM) and Ocean buoy measurements from Woods Hole Oceanographic Institute (WHOI).

  9. Neurocritical care update

    OpenAIRE

    Kuroda, Yasuhiro

    2016-01-01

    This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temperature modulation, is required. Analgosedation for target temperature management is an essential strategy to prevent shivering and minimizes endogenous stress induced by catecholamine surges. For severe traumatic brain injury, the diverse effects of therapeutic hypothermia depend on the c...

  10. First line treatment response in patients with transmitted HIV drug resistance and well defined time point of HIV infection: updated results from the German HIV-1 seroconverter study.

    Directory of Open Access Journals (Sweden)

    Fabia Zu Knyphausen

    Full Text Available BACKGROUND: Transmission of drug-resistant HIV-1 (TDR can impair the virologic response to antiretroviral combination therapy. Aim of the study was to assess the impact of TDR on treatment success of resistance test-guided first-line therapy in the German HIV-1 Seroconverter Cohort for patients infected with HIV between 1996 and 2010. An update of the prevalence of TDR and trend over time was performed. METHODS: Data of 1,667 HIV-infected individuals who seroconverted between 1996 and 2010 were analysed. The WHO drug resistance mutations list was used to identify resistance-associated HIV mutations in drug-naïve patients for epidemiological analysis. For treatment success analysis the Stanford algorithm was used to classify a subset of 323 drug-naïve genotyped patients who received a first-line cART into three resistance groups: patients without TDR, patients with TDR and fully active cART and patients with TDR and non-fully active cART. The frequency of virologic failure 5 to 12 months after treatment initiation was determined. RESULTS: Prevalence of TDR was stable at a high mean level of 11.9% (198/1,667 in the HIV-1 Seroconverter Cohort without significant trend over time. Nucleotide reverse transcriptase inhibitor resistance was predominant (6.0% and decreased significantly over time (OR = 0.92, CI = 0.87-0.98, p = 0.01. Non-nucleoside reverse transcriptase inhibitor (2.4%; OR = 1.00, CI = 0.92-1.09, p = 0.96 and protease inhibitor resistance (2.0%; OR = 0.94, CI = 0.861.03, p = 0.17 remained stable. Virologic failure was observed in 6.5% of patients with TDR receiving fully active cART, 5,6% of patients with TDR receiving non-fully active cART and 3.2% of patients without TDR. The difference between the three groups was not significant (p = 0.41. CONCLUSION: Overall prevalence of TDR remained stable at a rather high level. No significant differences in the frequency of virologic failure were

  11. Evaluation of Thompson's quadricepsplasty results in patients with knee stiffness resulted from femoral fracture

    Directory of Open Access Journals (Sweden)

    Hamid Mousavi

    2017-01-01

    Full Text Available Background: Posttraumatic and/or postsurgical knee stiffness is one of the orthopedic complications which is difficult to be treated and can affect individual's life negatively. The aim of this study is to investigate the results of quadricepsplasty in patients with knee stiffness resulted from femoral fracture. Materials and Methods: This is a cross-sectional study on all patients with femoral fracture which has caused knee flexion limitation referred to Kashani and Al-Zahra Hospitals in Isfahan from January 2010 to March 2013. The type and site of fracture, joint extension, and fracture fixation technique were recorded. Moreover, the range of motion (ROM before surgery, under general anesthesia, and 3- and 6-month postoperation were measured. Results: Among the patients, 13 had a simple fracture (48% and 14 had a segmental fracture (51.9%. Considering the fracture site, 11, 10, and 6 patients had femoral (40.74%, supracondylar (37.3%, and femoral supracondylar (22.2% fractures, respectively. The fracture fixation was performed by the plate, external, and Wagner fixation techniques for 24 (88.9%, 2 (7.4%, and 1 (3.7% patients, respectively. The mean ROM before operation, under general anesthesia, and 3- and 6-month postoperation were determined to be 33.15° ± 24.73°, 122.60° ± 10.22°, 99.63° ± 16.52°, and 100.74° ± 15.67°, respectively. The mean ROM value at various stages was not similar (P < 0.001. The mean changes in the ROM were 79.2° ± 24.6° and 62.1° ± 19.7° in the cases with simple and segmental fractures, respectively. The mean changes in the knee ROM were significantly higher in simple fractures in comparison with the segmental femoral fracture (P = 0.03. Conclusion: We found Thompson's quadricepsplasty may successfully increase the range of knee flexion in knee fracture and also regardless of quadriceps time.

  12. Public views of wetlands and waterfowl conservation in the United States—Results of a survey to inform the 2018 update of the North American Waterfowl Management Plan

    Science.gov (United States)

    Wilkins, Emily J.; Miller, Holly M.

    2018-01-24

    Executive SummaryThis report provides information from a general public survey conducted in early 2017 to help inform the North American Waterfowl Management Plan (NAWMP) 2018 update. This report is intended for use by the NAWMP advisory committees and anyone interested in the human dimensions of wetlands and waterfowl management. A mail-out survey was sent to 5,000 addresses in the United States, which were selected randomly in proportion to the population of each State. A total of 1,030 completed surveys representing 49 States were returned, resulting in a 23 percent overall response rate.When comparing the demographics of the respondents to the U.S. census data, this sample overrepresented people who are male, older, highly educated, and white. Data were weighted on gender and age to make the results more representative of the overall U.S. population. Additionally, this sample had higher participation rates in all wildlife-related recreation activities than has been found in previous studies; this indicates there may have been selection bias, with people interested in nature-related topics more likely to complete the survey. Therefore, results likely represent a segment of the U.S. public that is more oriented toward and aware of wildlife and conservation issues than the general public as a whole. Because of this bias, responses for each question were also broken down by recreationist type (hunters, anglers, wildlife viewers, and no wildlife-related recreation). Additionally, responses for each question were split by administrative flyway (Atlantic, Central, Mississippi, Pacific) and residency (urban, urban cluster, rural) to better understand the different groups.Most respondents knew of wetlands in their local area or community, and more than half had visited wetlands in the previous 12 months. Of those who had visited wetlands, the most common reasons were for walking/hiking/biking and enjoying nature/picnicking. In addition, this sample was very concerned

  13. Memory updating and mental arithmetic

    Directory of Open Access Journals (Sweden)

    Cheng-Ching eHan

    2016-02-01

    Full Text Available Is domain-general memory updating ability predictive of calculation skills or are such skills better predicted by the capacity for updating specifically numerical information? Here, we used multidigit mental multiplication (MMM as a measure for calculating skill as this operation requires the accurate maintenance and updating of information in addition to skills needed for arithmetic more generally. In Experiment 1, we found that only individual differences with regard to a task updating numerical information following addition (MUcalc could predict the performance of MMM, perhaps owing to common elements between the task and MMM. In Experiment 2, new updating tasks were designed to clarify this: a spatial updating task with no numbers, a numerical task with no calculation, and a word task. The results showed that both MUcalc and the spatial task were able to predict the performance of MMM but only with the more difficult problems, while other updating tasks did not predict performance. It is concluded that relevant processes involved in updating the contents of working memory support mental arithmetic in adults.

  14. Evaluating Teachers More Strategically: Using Performance Results to Streamline Evaluation Systems. Issue Brief

    Science.gov (United States)

    White, Taylor

    2014-01-01

    Teacher evaluation systems introduced by states and school systems in the past several years have focused attention on improving the performance of public school teachers, but they have been cost- and time-intensive, placing a significant burden on states' and districts' resources. In Tennessee, for example, trained evaluators conducted nearly…

  15. Report of the evaluation by the Ad Hoc Review Committee on Advance Science Research. Result evaluation, interim evaluation, in-advance evaluation in fiscal year 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Advanced Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the accomplishments of the research completed in Fiscal Year 2001, the accomplishments of the research started in Fiscal Year 2000, and the adequacy of the programs of the research to be started in Fiscal Year 2003 at Advanced Science Research Center of JAERI. The Ad Hoc Review Committee consisted of eight specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from May to July 2002. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 4, 2002, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 5, 2002. This report describes the result of the evaluation by the Ad Hoc Review Committee on Advanced Science Research. (author)

  16. Analyses of guide update approaches for vector evaluated particle swarm optimisation on dynamic multi-objective optimisation problems

    CSIR Research Space (South Africa)

    Helbig, M

    2012-06-01

    Full Text Available constraint violations on the performance of the Dynamic Vector Evaluated Particle Swarm Optimisation (DVEPSO) algorithm when solving DMOOPs. Furthermore, the performance of DVEPSO is compared against the performance of three other state-of-the-art dynamic...

  17. Mining Sequential Update Summarization with Hierarchical Text Analysis

    Directory of Open Access Journals (Sweden)

    Chunyun Zhang

    2016-01-01

    Full Text Available The outbreak of unexpected news events such as large human accident or natural disaster brings about a new information access problem where traditional approaches fail. Mostly, news of these events shows characteristics that are early sparse and later redundant. Hence, it is very important to get updates and provide individuals with timely and important information of these incidents during their development, especially when being applied in wireless and mobile Internet of Things (IoT. In this paper, we define the problem of sequential update summarization extraction and present a new hierarchical update mining system which can broadcast with useful, new, and timely sentence-length updates about a developing event. The new system proposes a novel method, which incorporates techniques from topic-level and sentence-level summarization. To evaluate the performance of the proposed system, we apply it to the task of sequential update summarization of temporal summarization (TS track at Text Retrieval Conference (TREC 2013 to compute four measurements of the update mining system: the expected gain, expected latency gain, comprehensiveness, and latency comprehensiveness. Experimental results show that our proposed method has good performance.

  18. Strategies for monitoring and updating clinical practice guidelines: a systematic review

    Directory of Open Access Journals (Sweden)

    Martínez García Laura

    2012-11-01

    Full Text Available Abstract Background Scientific knowledge is in constant change. The flow of new information requires a frequent re-evaluation of the available research results. Clinical practice guidelines (CPGs are not exempted from this phenomenon and need to be kept updated to maintain the validity of their recommendations. The objective of our review is to systematically identify, describe and assess strategies for monitoring and updating CPGs. Study design and setting We conducted a systematic review of studies evaluating one or more methods of updating (with or without monitoring CPGs or recommendations. We searched MEDLINE (PubMed and The Cochrane Methodology Register (The Cochrane Library from 1966 to June 2012. Additionally, we hand-searched reference lists of the included studies and the Guidelines International Network book of abstracts. If necessary, we contacted study authors to obtain additional information. Results We included a total of eight studies. Four evaluated if CPGs were out of date, three updated CPGs, and one continuously monitored and updated CPGs. The most detailed reported phase of the process was the identification of new evidence. As opposed to studies updating guidelines, studies evaluating if CPGs were out of date applied restricted searches. Only one study compared a restricted versus an exhaustive search suggesting that a restricted search is sufficient to assess recommendations’ Validity. One study analyzed the survival time of CPGs and suggested that these should be reassessed every three years. Conclusions There is limited evidence about the optimal strategies for monitoring and updating clinical practice guidelines. A restricted search is likely to be sufficient to monitor new evidence and assess the need to update, however, more information is needed about the timing and type of search. Only the exhaustive search strategy has been assessed for the update of CPGs. The development and evaluation of more efficient

  19. Cardiology update

    Directory of Open Access Journals (Sweden)

    Sunil K Verma

    2015-01-01

    Full Text Available In the year 2014, there were certain remarkable trials that have changed the practice of cardiology and beyond that these tried to explained some long awaited unanswered questions. Like SIMPLICITY HTN-3 trial clearly explained the uselessness of renal denervation therapy in systemic hypertension. PARADIGM-HF trial provided positive data that may be useful to enrich the basket of medical treatment with a new drug LCZ 696 after a long time. Another important meta-analysis in heart failure questioned the status of beta blockers as standard therapy to improve prognosis in patients with concomitant heart failure and atrial fibrillation . In myocardial infraction , CvLPRIT trial supported the concept of complete revascularization at the time of primary PCI and TASTE trials failed to show expected benefit of thrombus aspiration in acute MI. FFR got more strength from FAME 2 trial. Another important question that was addressed in SECURITY trial was optimal duration of DAPT after second generation DES implantation. One year follow-up results of ABSORB II suggested that bioresorbable scaffolds are currently facing problem of stent thrombosis that might be taken care in near future with improvement in strut technology. Successful use of "Heart in a box" machine provided a major thrust for cardiac transplantation. SEARCH-AF evaluated the efficacy of a novel mobile health technology in the real world to screen for atrial fibrillation (now called as life style disease. A Meta-analysis provided a more comprehensive picture of the new oral anticoagulants as a therapeutic option in atrial fibrillation. Positive results for trans catheter pm-VSD closure in paediatric population were also demonstrated by a randomized controlled trial. Role of corticosteroids in tubercular pericarditis also got the answer in a trial published in 2014.

  20. Test results evaluation: Pilot evaluations Deliverable no D6.5. Final draft

    NARCIS (Netherlands)

    Hoedemaeker, D.M.; Dangelmaier, M.; Gelau, C.; Mattes, S.; Montanari, R.

    2003-01-01

    This deliverable describes the User Centred Design approach that has been adopted within the COMUNICAR project. In this design approach several iterative steps were taken to design and evaluate the multimedia Human Machine Interface that is able to manage all the information exchanges between the

  1. Decentralized Consistent Updates in SDN

    KAUST Repository

    Nguyen, Thanh Dang

    2017-04-10

    We present ez-Segway, a decentralized mechanism to consistently and quickly update the network state while preventing forwarding anomalies (loops and blackholes) and avoiding link congestion. In our design, the centralized SDN controller only pre-computes information needed by the switches during the update execution. This information is distributed to the switches, which use partial knowledge and direct message passing to efficiently realize the update. This separation of concerns has the key benefit of improving update performance as the communication and computation bottlenecks at the controller are removed. Our evaluations via network emulations and large-scale simulations demonstrate the efficiency of ez-Segway, which compared to a centralized approach, improves network update times by up to 45% and 57% at the median and the 99th percentile, respectively. A deployment of a system prototype in a real OpenFlow switch and an implementation in P4 demonstrate the feasibility and low overhead of implementing simple network update functionality within switches.

  2. Radiotherapy: An Update

    Directory of Open Access Journals (Sweden)

    Vikrant Kasat

    2010-01-01

    Full Text Available Radiotherapy is the art of using ionizing radiation to destroy malignant cells while minimizing damage to normal tissue. Radiotherapy has become a standard treatment option for a wide range of malignancies. Several new imaging techniques, both anatomical and functional are currently being evaluated as well as practiced for treatment planning of cancer. These recent developments have allowed radiation oncologists to escalate the dose of radiation delivered to tumors while minimizing the dose delivered to surrounding normal tissue. In this update, we attempt to pen down important aspects of radiotherapy.

  3. Emergency evacuation/transportation plan update: Traffic model development and evaluation of early closure procedures. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-10-28

    Prolonged delays in traffic experienced by Laboratory personnel during a recent early dismissal in inclement weather, coupled with reconstruction efforts along NM 502 east of the White Rock Wye for the next 1 to 2 years, has prompted Los Alamos National Laboratory (LANL) to re-evaluate and improve the present transportation plan and its integration with contingency plans maintained in other organizations. Facilities planners and emergency operations staff need to evaluate the transportation system`s capability to inefficiently and safely evacuate LANL under different low-level emergency conditions. A variety of potential procedures governing the release of employees from the different technical areas (TAs) requires evaluation, perhaps with regard to multiple emergency-condition scenarios, with one or more optimal procedures ultimately presented for adoption by Lab Management. The work undertaken in this project will hopefully lay a foundation for an on-going, progressive transportation system analysis capability. It utilizes microscale simulation techniques to affirm, reassess and validate the Laboratory`s Early Dismissal/Closure/Delayed Opening Plan. The Laboratory is required by Federal guidelines, and compelled by prudent practice and conscientious regard for the welfare of employees and nearby residents, to maintain plans and operating procedures for evacuation if the need arises. The tools developed during this process can be used outside of contingency planning. It is anticipated that the traffic models developed will allow site planners to evaluate changes to the traffic network which could better serve the normal traffic levels. Changes in roadway configuration, control strategies (signalization and signing), response strategies to traffic accidents, and patterns of demand can be modelled using the analysis tools developed during this project. Such scenarios typically are important considerations in master planning and facilities programming.

  4. Results

    African Journals Online (AJOL)

    child.” (CIN, breastfeeding mother). “I am terribly stressed when I consider that the baby will be crying a lot and become difficult and this may force me to continue breastfeeding.” (FGD, breastfeeding mother). Women cited intense psychological stress when children were ill. This influenced them to re-evaluate their decision.

  5. Herpes Labialis: An Update.

    Science.gov (United States)

    Leung, Alexander K C; Barankin, Benjamin

    2017-01-01

    Herpes labialis is characterized by recurrent vesicular eruptions primarily on the lips and perioral skin. The condition is contagious, can cause significant discomfort/pain, and can have an adverse effect on the quality of life. To update the evaluation and treatment of herpes labialis. A PubMed search was completed in Clinical Queries using the key term "herpes labialis". Patents were searched using the key term "herpes labialis" from www.freepatentsonline.com. The diagnosis of herpes labialis is mainly clinical based on classic grouped lesions (papules, vesicles, ulcers) on the lip. Antiviral therapy shortens the duration of pain and discomfort, hastens healing, and reduces viral shedding. Thus, episodic treatment is warranted, especially if the patient desires treatment for cosmetic purposes or for relief of pain. Such treatment needs to be initiated promptly, ideally in the prodromal stage and no later than 48 hours from the onset of lesions to achieve optimal results. Chronic suppressive therapy with oral antiviral agents should be considered for patients with severe or frequent (six or more episodes per year) recurrences. Recent patents related to the management of herpes labialis are also discussed. For episodic treatment, oral antiviral agents, such as acyclovir (Zovirax), valacyclovir (Valtrex) and famciclovir (Famvir), are superior to topical antiviral therapy. Valacyclovir and famciclovir have greater oral bioavailability and are better absorbed than acyclovir, require less frequent dosing, but are more expensive and are not approved for children. Topical antiviral agents such as 5% acyclovir cream/ointment (Zovirax) ± hydrocortisone (Xerese), 1% penciclovir (Denavir) cream, and 50 mg Buccal Adhesive Tablet (ABT-50 mg) can also be used for episodic treatment of herpes labialis. These topical agents are not effective in the prevention of recurrent herpes labialis. For chronic daily suppressive therapy, oral antivirals are the treatment of choice

  6. Updated results of high-dose rate brachytherapy and external beam radiotherapy for locally and locally advanced prostate cancer using the RTOG-ASTRO phoenix definition

    Directory of Open Access Journals (Sweden)

    Antonio C. Pellizzon

    2008-06-01

    Full Text Available PURPOSE: To evaluate the prognostic factors for patients with local or locally advanced prostate cancer treated with external beam radiotherapy (RT and high dose rate brachytherapy (HDR according to the RTOG-ASTRO Phoenix Consensus Conference. MATERIALS AND METHODS: The charts of 209 patients treated between 1997 and 2005 with localized RT and HDR as a boost at the Department of Radiation Oncology, AC Camargo Hospital, Sao Paulo, Brazil were reviewed. Clinical and treatment parameters i.e.: patient's age, Gleason score, clinical stage, initial PSA (iPSA, risk group (RG for biochemical failure, doses of RT and HDR were evaluated. Median age and median follow-up time were 68 and 5.3 years, respectively. Median RT and HDR doses were 45 Gy and 20 Gy. RESULTS: Disease specific survival (DSS at 3.3 year was 94.2%. Regarding RG, for the LR (low risk, IR (intermediate risk and HR (high risk, the DSS rates at 3.3 years were 91.5%, 90.2% and 88.5%, respectively. On univariate analysis prognostic factors related to DSS were RG (p = 0.040, Gleason score ≤ 6 ng/mL (p = 0.002, total dose of HDR ≥ 20 Gy (p < 0.001 On multivariate analysis the only statistical significant predictive factor for biochemical control (bNED was the RG, p < 0.001 (CI - 1.147-3.561. CONCLUSIONS: Although the radiation dose administered to the prostate is an important factor related to bNED, this could not be established with statistical significance in this group of patients. To date , in our own experience, HDR associated to RT could be considered a successful approach in the treatment of prostate cancer.

  7. The updated billion-ton resource assessment

    Science.gov (United States)

    Anthony Turhollow; Robert Perlack; Laurence Eaton; Matthew Langholtz; Craig Brandt; Mark Downing; Lynn Wright; Kenneth Skog; Chad Hellwinckel; Bryce Stokes; Patricia Lebow

    2014-01-01

    This paper summarizes the results of an update to a resource assessment, published in 2005, commonly referred to as the Billion-Ton Study (BTS). The updated results are consistent with the 2005 BTS in terms of overall magnitude. The 2005 BTS projected between 860 and 1240 Tg of biomass available in the 2050 timeframe, while the Billion-Ton Update (BT2), for a price of...

  8. Chemical Kinetics and Photochemical Data for Use in Atmospheric Studies Evaluation Number 16. Supplement to Evaluation 15: Update of Key Reactions

    Science.gov (United States)

    Sander, S. P.; Friedl, R. R.; Barker, J. R.; Golden, D. M.; Kurylo, M. J.; Wine, P. H.; Abbatt, J.; Burkholder, J. B.; Kolb, C. E.; Moortgat, G. K.; hide

    2009-01-01

    This is the supplement to the fifteenth in a series of evaluated sets of rate constants and photochemical cross sections compiled by the NASA Panel for Data Evaluation. The data are used primarily to model stratospheric and upper tropospheric processes, with particular emphasis on the ozone layer and its possible perturbation by anthropogenic and natural phenomena. Copies of this evaluation are available in electronic form and may be printed from the following Internet URL: http://jpldataeval.jpl.nasa.gov/.

  9. Hypopharyngeal evaluation in obstructive sleep apnea with awake flexible laryngoscopy: Validation and updates to Cormack-Lehane and Modified Cormack-Lehane scoring systems.

    Science.gov (United States)

    Torre, C; Zaghi, S; Camacho, M; Capasso, R; Liu, S Y

    2017-12-26

    To validate the use of Cormack-Lehane and Modified Cormack-Lehane scoring systems to classify patterns of hypopharyngeal airway visualization seen during awake flexible laryngoscopy among patients with obstructive sleep apnoea. Validation study using samples collected from a prospective database. University Medical Center. Data were obtained from a retrospective review of a prospective database of flexible fiberoptic examination recordings in 274 consecutive OSA subjects (Stanford Sleep Medicine/Surgery Clinic). Single still images from awake fiberoptic laryngoscopy examinations of the vocal cords from 90 different patients were presented to 2 experts and 4 novice raters. Raters used two grading systems (Cormack-Lehane scale and Modified Cormack-Lehane) to rate vocal cord visualization. Percent agreement and Cohen's kappa statistical analysis were used to evaluate inter-rater reliability and intrarater reliability for each grading system. Feedback from the participants was then used to propose updates to further improve upon the existing grading scales for their applicability to awake flexible endoscopy. The Cormack-Lehane and Modified Cormack-Lehane scale both communicate unobstructed and restricted views of the vocal cords reliably. Compared to the 4-grade scale, however, a modified 5-grade Vocal Cord Grading System allows for better objective communication of common variations in hypopharyngeal airway visualization. We propose a 5-Grade Vocal Cord Grading System that builds upon existing grading systems to allow for efficient and reliable communication of hypopharyngeal airway examination during awake fiberoptic laryngoscopy. © 2017 John Wiley & Sons Ltd.

  10. Evaluation of English Results Course Books at Upper-Intermediate Level

    Science.gov (United States)

    Haghi, Eshrat Bazarmaj

    2013-01-01

    The importance of the course books in language teaching leads the way to the evaluation of them. Evaluating the teaching materials specially course books can help teachers to understand more about language learning. The purpose of the present study is to evaluate English Results course books which are widely used at Iranian institutes. The focus…

  11. The Second Flight of the Sunrise Balloon-borne Solar Observatory: Overview of Instrument Updates, the Flight, the Data, and First Results

    Energy Technology Data Exchange (ETDEWEB)

    Solanki, S. K.; Riethmüller, T. L.; Barthol, P.; Danilovic, S.; Deutsch, W.; Doerr, H.-P.; Feller, A.; Gandorfer, A.; Germerott, D.; Gizon, L.; Grauf, B.; Heerlein, K.; Hirzberger, J.; Kolleck, M.; Lagg, A.; Meller, R.; Tomasch, G.; Noort, M. van [Max Planck Institute for Solar System Research, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany); Rodríguez, J. Blanco; Blesa, J. L. Gasent, E-mail: solanki@mps.mpg.de [Grupo de Astronomía y Ciencias del Espacio, Universidad de Valencia, E-46980 Paterna, Valencia (Spain); and others

    2017-03-01

    The Sunrise balloon-borne solar observatory, consisting of a 1 m aperture telescope that provides a stabilized image to a UV filter imager and an imaging vector polarimeter, carried out its second science flight in 2013 June. It provided observations of parts of active regions at high spatial resolution, including the first high-resolution images in the Mg ii k line. The obtained data are of very high quality, with the best UV images reaching the diffraction limit of the telescope at 3000 Å after Multi-Frame Blind Deconvolution reconstruction accounting for phase-diversity information. Here a brief update is given of the instruments and the data reduction techniques, which includes an inversion of the polarimetric data. Mainly those aspects that evolved compared with the first flight are described. A tabular overview of the observations is given. In addition, an example time series of a part of the emerging active region NOAA AR 11768 observed relatively close to disk center is described and discussed in some detail. The observations cover the pores in the trailing polarity of the active region, as well as the polarity inversion line where flux emergence was ongoing and a small flare-like brightening occurred in the course of the time series. The pores are found to contain magnetic field strengths ranging up to 2500 G, and while large pores are clearly darker and cooler than the quiet Sun in all layers of the photosphere, the temperature and brightness of small pores approach or even exceed those of the quiet Sun in the upper photosphere.

  12. A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update.

    Science.gov (United States)

    Cornu, Jean-Nicolas; Ahyai, Sascha; Bachmann, Alexander; de la Rosette, Jean; Gilling, Peter; Gratzke, Christian; McVary, Kevin; Novara, Giacomo; Woo, Henry; Madersbacher, Stephan

    2015-06-01

    A number of transurethral ablative techniques based on the use of innovative medical devices have been introduced in the recent past for the surgical treatment of benign prostatic obstruction (BPO). To conduct a systematic review of the literature and a meta-analysis of available randomized controlled trials (RCTs), and to evaluate the efficacy and safety of transurethral ablative procedures for BPO. A systematic literature search was performed for all RCTs comparing any transurethral surgical technique for BPO to another between 1992 and 2013. Efficacy was evaluated after a minimum follow-up of 1 yr based on International Prostate Symptom Score, maximum flow rate, and postvoid residual volume. Efficacy at midterm follow-up, prostate volume, perioperative data, and short-term and long-term complications were also assessed. Data were analyzed using RevMan software. A total of 69 RCTs (8517 enrolled patients) were included. No significant difference was found in terms of short-term efficacy between bipolar transurethral resection of the prostate (B-TURP) and monopolar transurethral resection of the prostate (M-TURP). However, B-TURP was associated with a lower rate of perioperative complications. Better short-term efficacy outcomes, fewer immediate complications, and a shorter hospital stay were found after holmium laser enucleation of the prostate (HoLEP) compared with M-TURP. Compared with M-TURP, GreenLight photoselective vaporization of the prostate (PVP) was associated with a shorter hospital stay and fewer complications but no different short-term efficacy outcomes. This meta-analysis shows that HoLEP is associated with more favorable outcomes than M-TURP in published RCTs. B-TURP and PVP have resulted in better perioperative outcomes without significant differences regarding efficacy parameters after short-term follow-up compared with M-TURP. Further studies are needed to provide long-term comparative data and head-to head comparisons of emerging techniques

  13. Scientometric evaluation of the global research in spine: an update on the pioneering study by Wei et al.

    Science.gov (United States)

    Konur, Ozcan

    2017-12-01

    Wei et al. evaluated the global research in spine using scientometric methods based on a sample of 13,115 papers published in 5 spine journals from 2004 to 2013. This study builds on this pioneering study and provides up-to-date and thorough information on spine based on a sample of 166,962 papers for the stakeholders. 'Articles' and 'reviews' published in 'English' in the journals indexed by the 'Web of Science' primary databases between 1980 and 2017 were retrieved through the use of an optimal keyword set for titles of both papers and ten spine journals. The information on document types and number of papers, authors, countries, funding bodies, institutions, publication years, journals, 'Web of Science' subject categories, and ten top citation classics were analyzed. A large sample of 166,962 papers were retrieved. The 'reviews' and 'proceedings papers' formed 5.8 and 2.8% of the sample, respectively. 'Fehlings', 'Vaccaro', 'Takahashi', 'Lenke', and 'Gokaslan' were the most-prolific authors. Nearly 0.7% of the papers had group authors besides single authors. The US was the most prolific country publishing 37.3% of the sample whilst Europe contributed to more than 39.8% of the sample. Only, 26.6% of the papers disclosed research funding. Among 40,897 institutions, 'Harvard University' was the most-prolific institution whilst the US institutions dominated the top-institution list. The research output steadily rose from 1375 papers in 1980 to 9357 papers in 2016 whilst 69.2% of the papers were published after 2000. Ten spine journals published only 23.4% of the sample. 'Clinical Neurology', 'Orthopedics', 'Neurosciences', and 'Surgery' was the most prolific subject categories. The top citation classic was a paper by van der Linden et al. on ankylosing spondylitis. The optimal design of research sample made it possible to obtain nearly 13 times the size of the sample in Wei et al. as a true representation of the research in spine through the use of an optimal

  14. First line treatment response in patients with transmitted HIV drug resistance and well defined time point of HIV infection: updated results from the German HIV-1 seroconverter study.

    Science.gov (United States)

    Zu Knyphausen, Fabia; Scheufele, Ramona; Kücherer, Claudia; Jansen, Klaus; Somogyi, Sybille; Dupke, Stephan; Jessen, Heiko; Schürmann, Dirk; Hamouda, Osamah; Meixenberger, Karolin; Bartmeyer, Barbara

    2014-01-01

    Transmission of drug-resistant HIV-1 (TDR) can impair the virologic response to antiretroviral combination therapy. Aim of the study was to assess the impact of TDR on treatment success of resistance test-guided first-line therapy in the German HIV-1 Seroconverter Cohort for patients infected with HIV between 1996 and 2010. An update of the prevalence of TDR and trend over time was performed. Data of 1,667 HIV-infected individuals who seroconverted between 1996 and 2010 were analysed. The WHO drug resistance mutations list was used to identify resistance-associated HIV mutations in drug-naïve patients for epidemiological analysis. For treatment success analysis the Stanford algorithm was used to classify a subset of 323 drug-naïve genotyped patients who received a first-line cART into three resistance groups: patients without TDR, patients with TDR and fully active cART and patients with TDR and non-fully active cART. The frequency of virologic failure 5 to 12 months after treatment initiation was determined. Prevalence of TDR was stable at a high mean level of 11.9% (198/1,667) in the HIV-1 Seroconverter Cohort without significant trend over time. Nucleotide reverse transcriptase inhibitor resistance was predominant (6.0%) and decreased significantly over time (OR = 0.92, CI = 0.87-0.98, p = 0.01). Non-nucleoside reverse transcriptase inhibitor (2.4%; OR = 1.00, CI = 0.92-1.09, p = 0.96) and protease inhibitor resistance (2.0%; OR = 0.94, CI = 0.861.03, p = 0.17) remained stable. Virologic failure was observed in 6.5% of patients with TDR receiving fully active cART, 5,6% of patients with TDR receiving non-fully active cART and 3.2% of patients without TDR. The difference between the three groups was not significant (p = 0.41). Overall prevalence of TDR remained stable at a rather high level. No significant differences in the frequency of virologic failure were identified during first-line cART between patients with TDR

  15. [Educational differences in smoking and smoking cessation among young adults. Results from the "German Health Update" (GEDA) Study 2009 and 2010].

    Science.gov (United States)

    Kuntz, B; Hoebel, J; Lampert, T

    2014-10-01

    Studies show that adolescents attending upper secondary schools are less likely to smoke than their peers attending lower secondary school types. This article examines how educational differences in smoking behaviour continue in young adulthood. Besides frequency and intensity of tobacco use the main focus is on smoking cessation. The analyses were based on information of the 18- to 29-year-old men and women who participated in the nationwide representative telephone survey "German Health Update" (GEDA) 2009 and 2010 carried out by the Robert Koch Institute (n=7,620). Smoking behaviour was measured by several questions on smoking frequency and intensity. Educational status was assessed by the highest school-leaving certificate and classified as low (no school-leaving certificate/Hauptschule certificate), middle (General Certificate of Secondary Education/Realschule certificate), and high (general qualification for university entrance (Abitur)/advanced technical college entrance qualification). In addition to prevalence estimates, age-adjusted odds ratios (OR) and corresponding 95% confidence intervals (95% CI) were calculated using logistic regression. According to the GEDA study, the prevalence of smoking was 42.6% among men and 36.7% among women aged 18-29 years. The prevalence of current smoking increased with decreasing educational level. The odds of current smoking was 3.72-times higher in lower as compared to higher educated men (95% CI 2.90-4.77) and 3.00-times higher in lower as compared to higher educated women (95% CI 2.30-3.92). Moreover, high intensity of tobacco use was also associated with lower education in men and women. The odds of successful quitting was significantly reduced in the lowest compared to the highest educational group (men: OR=0.45; 95% CI 0.31-0.66; women: OR=0.65; 95% CI 0.44-0.94). Our findings suggest that young adults with low education are more likely to start smoking and less likely to quit than their higher educated peers

  16. Geologic evolution of the dwarf planet (1) Ceres: results from geologic mapping using Dawn FC2 camera imaging data and an update in cratering model ages

    Science.gov (United States)

    Wagner, Roland J.; Schmedemann, Nico; Stephan, Katrin; Jaumann, Ralf; Neesemann, Adrian; Krohn, Katrin; Otto, Katharina; Preusker, Frank; Kersten, Elke; Roatsch, Thomas; Hiesinger, Harald; Williams, David A.; Aileen Yingst, R.; Crown, David A.; Mest, Scott C.; Raymond, Carol A.; Russell, Christopher T.

    2017-04-01

    The Dawn spacecraft, in orbit around the dwarf planet (1) Ceres since March 6, 2015, has carried out global imaging with the FC2 framing camera in three orbital phases: Survey (4424 km altitude above the surface; 400 m/pxl spatial resolution), high-altitude (HAMO; 1475 km; 140 m/pxl) and low-altitude mapping orbit (LAMO; 375 km; 30 m/pxl) [1]. In this study we combine FC images with topographic data from digital elevation models (DEMs) for geologic mapping and age determination with crater size-frequency distribution measurements. For the latter we use an updated impact chronology model [2]. Globally, Ceres' surface is characterized by ubiquitous cratered plains, separable in units with higher or lower crater frequencies at high, medium, and low topographic levels. A second major geologic unit are individual impact craters with a wide range of morphologies. Craters provide important stratigraphic markers, especially the larger ones, those with rays, or craters with specific spectral properties. A third remarkable type of surface features are mountains. Densely cratered plains occur at all three topographic levels, but no correlation between absolute mode age (AMA) and topographic position can be found. In a lunar-derived model chronology [2], AMAs are on the order of 3 - 3.4 Ga, i.e., younger than in a previous version of the model. The three large major impact features characterizing time boundaries in Ceres' geologic history, Kerwan, Yalode, and Urvara, have AMAs [2] of 1.1 ± 0.2 Ga, 540 ± 80 Ma, and 120 ± 20 Ma, respectively. Other craters whose superimposed crater frequencies were measured in Survey images show wide ranges in AMAs, such as Asari (2.8 ± 0.6 Ga), Jarovit (2.1 ± 1.0 Ga), Ghanan (980 ± 380 Ma), or Dantu (AMAs range from 65 ± 20 Ma (ejecta) to 30 ± 15 Ma (floor)). The enigmatic feature Ahuna Mons, a mountain several kilometers high, has an AMA of 2 ± 0.8 Ma measured on its summit region indicating that Ceres most likely was geologically

  17. Evaluation of the updated RIDA®QUICK (Version N1402) immunochromatographic assay for the detection of norovirus in clinical specimens.

    Science.gov (United States)

    Bruggink, Leesa D; Dunbar, Natalie L; Marshall, John A

    2015-10-01

    The sensitivity and specificity of the R-Biopharm RIDA(®)QUICK (N1402) immunochromatography assay for norovirus detection was examined using fecal material from Australian gastroenteritis incidents. The study involved the analysis of 3 groups of specimens; group 1 comprised 100 norovirus open reading frame (ORF) 1 RT-PCR positive specimens; group 2 comprised 100 ORF 1 RT-PCR norovirus negative specimens and group 3 comprised 12 specimens containing common gastroenteritis viruses other than norovirus. The RIDA(®)QUICK (N1402) assay detected both GI and GII norovirus and had an overall sensitivity of 87%. Genotype analysis of the capsid region of the genome (ORF 2) indicated the RIDA(®)QUICK (N1402) assay could detect a range of genotypes including GI.1, GI.2, GI.3, GI.4, GI.5, GII.3, GII.4 (including variants GII.4 (2009-like), GII.4 (2012), GII.4 (2012-like) and GII.4 (unknown)), GII.6, GII.13 and GII.21. The assay had good sensitivity for both GI and GII norovirus. The assay had a specificity of 97% and did not cross react with a number of common fecal viruses. However, one of eight rotavirus positive, norovirus negative specimens gave a positive result; rotavirus cannot be taken as the cause of such a false positive but cannot be excluded either. The kit was quick and easy to use and would be valuable in point-of-care testing. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Bayesian and Non-Bayesian Evidential Updating

    Science.gov (United States)

    1984-01-01

    in the frame%ork of convex sets of classical probabilities b% classical conditionalization. (4) The probabilit. interxals that result from Dempster...Shafer updating on uncertain eidence are includedin (and may be properly included in) the interxals that result from Baesian updating on uncertain e

  19. Global Positioning Systems Directorate: GPS Update

    Science.gov (United States)

    2015-04-29

    Evaluation of the Early CNAV Navigation Message", Pstre igenberger. 0 . Montenbruck, U. Hessels ; Study conducted in Europe. 2015 04 29 _ GPS Update Partnership c ounci12015 v6 UNCLASSIFIED/APPROVED FOR PUBLIC RELEASE 12

  20. Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology.

    Science.gov (United States)

    Giza, Christopher C; Kutcher, Jeffrey S; Ashwal, Stephen; Barth, Jeffrey; Getchius, Thomas S D; Gioia, Gerard A; Gronseth, Gary S; Guskiewicz, Kevin; Mandel, Steven; Manley, Geoffrey; McKeag, Douglas B; Thurman, David J; Zafonte, Ross

    2013-06-11

    To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What diagnostic tools identify those with concussion and those at increased risk for severe/prolonged early impairments, neurologic catastrophe, or chronic neurobehavioral impairment? 3) What clinical factors identify those at increased risk for severe/prolonged early postconcussion impairments, neurologic catastrophe, recurrent concussions, or chronic neurobehavioral impairment? 4) What interventions enhance recovery, reduce recurrent concussion risk, or diminish long-term sequelae? The complete guideline on which this summary is based is available as an online data supplement to this article. We systematically reviewed the literature from 1955 to June 2012 for pertinent evidence. We assessed evidence for quality and synthesized into conclusions using a modified Grading of Recommendations Assessment, Development and Evaluation process. We used a modified Delphi process to develop recommendations. Specific risk factors can increase or decrease concussion risk. Diagnostic tools to help identify individuals with concussion include graded symptom checklists, the Standardized Assessment of Concussion, neuropsychological assessments, and the Balance Error Scoring System. Ongoing clinical symptoms, concussion history, and younger age identify those at risk for postconcussion impairments. Risk factors for recurrent concussion include history of multiple concussions, particularly within 10 days after initial concussion. Risk factors for chronic neurobehavioral impairment include concussion exposure and APOE ε4 genotype. Data are insufficient to show that any intervention enhances recovery or diminishes long-term sequelae postconcussion. Practice recommendations are presented for preparticipation counseling, management of suspected concussion, and management of diagnosed concussion.

  1. Updated of the events tree of total loss of power at the site, SBO, taking into account the results of stress tests and methodological updates, convolution, and hydraulic power recovery from model RCPs; Actualizacion del arbol de sucesos de perdida total de suministro electro en el emplazamiento, SBO, teniendo en cuenta los resultados de los estres tests y actualizaciones metodologicas, convolucion, recuperacion desde centrales hidraulicas y modelo de sellos de las RCPs

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Lorenzo, M. A.; Perez Martin, F.

    2013-07-01

    In this paper, is described a tree of events to an accident loss total power at the site (SBO) considering, first the results of stress tests arising from the Fukushima accident and moreover, various methodological updates related to this initiating event.

  2. PRELIMINARY RESULTS: EVALUATIONS OF THE ALTERNATIVE ASBESTOS CONTROL METHOD FOR BUILDING DEMOLITION

    Science.gov (United States)

    This presentation describes the preliminary results of the evaluations of the alternative asbestos control method for demolishing buildings containing asbestos, and are covered under the regulatory requirements of the Asbestos NESHAP. This abstract and presentation are based, at ...

  3. A statistical evaluation of factors influencing aerial survey results on brown bears

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report is a statistical evaluation of factors influencing aerial survey results on Brown Bears. The purpose of this study was to provide a statistical...

  4. Updating systematic reviews: an international survey.

    Directory of Open Access Journals (Sweden)

    Chantelle Garritty

    Full Text Available BACKGROUND: Systematic reviews (SRs should be up to date to maintain their importance in informing healthcare policy and practice. However, little guidance is available about when and how to update SRs. Moreover, the updating policies and practices of organizations that commission or produce SRs are unclear. METHODOLOGY/PRINCIPAL FINDINGS: The objective was to describe the updating practices and policies of agencies that sponsor or conduct SRs. An Internet-based survey was administered to a purposive non-random sample of 195 healthcare organizations within the international SR community. Survey results were analyzed using descriptive statistics. The completed response rate was 58% (n = 114 from across 26 countries with 70% (75/107 of participants identified as producers of SRs. Among responders, 79% (84/107 characterized the importance of updating as high or very-high and 57% (60/106 of organizations reported to have a formal policy for updating. However, only 29% (35/106 of organizations made reference to a written policy document. Several groups (62/105; 59% reported updating practices as irregular, and over half (53/103 of organizational respondents estimated that more than 50% of their respective SRs were likely out of date. Authors of the original SR (42/106; 40% were most often deemed responsible for ensuring SRs were current. Barriers to updating included resource constraints, reviewer motivation, lack of academic credit, and limited publishing formats. Most respondents (70/100; 70% indicated that they supported centralization of updating efforts across institutions or agencies. Furthermore, 84% (83/99 of respondents indicated they favoured the development of a central registry of SRs, analogous to efforts within the clinical trials community. CONCLUSIONS/SIGNIFICANCE: Most organizations that sponsor and/or carry out SRs consider updating important. Despite this recognition, updating practices are not regular, and many organizations lack

  5. Dynamic finite element model updating of prestressed concrete continuous box-girder bridge

    Science.gov (United States)

    Lin, Xiankun; Zhang, Lingmi; Guo, Qintao; Zhang, Yufeng

    2009-09-01

    The dynamic finite element model (FEM) of a prestressed concrete continuous box-girder bridge, called the Tongyang Canal Bridge, is built and updated based on the results of ambient vibration testing (AVT) using a real-coded accelerating genetic algorithm (RAGA). The objective functions are defined based on natural frequency and modal assurance criterion (MAC) metrics to evaluate the updated FEM. Two objective functions are defined to fully account for the relative errors and standard deviations of the natural frequencies and MAC between the AVT results and the updated FEM predictions. The dynamically updated FEM of the bridge can better represent its structural dynamics and serve as a baseline in long-term health monitoring, condition assessment and damage identification over the service life of the bridge.

  6. Neurocritical care update.

    Science.gov (United States)

    Kuroda, Yasuhiro

    2016-01-01

    This update comprises six important topics under neurocritical care that require reevaluation. For post-cardiac arrest brain injury, the evaluation of the injury and its corresponding therapy, including temperature modulation, is required. Analgosedation for target temperature management is an essential strategy to prevent shivering and minimizes endogenous stress induced by catecholamine surges. For severe traumatic brain injury, the diverse effects of therapeutic hypothermia depend on the complicated pathophysiology of the condition. Continuous electroencephalogram monitoring is an essential tool for detecting nonconvulsive status epilepticus in the intensive care unit (ICU). Neurocritical care, including advanced hemodynamic monitoring, is a fundamental approach for delayed cerebral ischemia following subarachnoid hemorrhage. We must be mindful of the high percentage of ICU patients who may develop sepsis-associated brain dysfunction.

  7. ILRS Website Update

    Science.gov (United States)

    Noll, Carey E.; Torrence, Mark H.; Pollack, Nathan H.; Tyahla, Lori J.

    2013-01-01

    The ILRS website, http://ilrs.gsfc.nasa.gov, is the central source of information for all aspects of the service. The website provides information on the organization and operation of the ILRS and descriptions of ILRS components data, and products. Furthermore, the website provides an entry point to the archive of these data products available through the data centers. Links are provided to extensive information on the ILRS network stations including performance assesments and data quality evaluations. Descriptions of suported satellite missions (current, future, and past) are provided to aid in station acquisition and data analysis. The website was reently redesigned. Content was reviewed during the update process, ensuring information is current and useful. This poster will provide specific examples of key sections, applicaitons, and webpages.

  8. [Results of a Representative Survey on the Psychosocial Evaluation Before Living Donor Kidney Transplantation in Germany].

    Science.gov (United States)

    de Zwaan, Martina; Erim, Yesim; Greif-Higer, Gertrud; Kröncke, Sylvia; Burgmer, Markus; Vitinius, Frank; Kunze, Sabine; Berth, Hendrik

    2017-06-01

    Aim Since there is no consensus about how to perform the predonation psychosocial evaluation of living kidney donor candidates, this is conducted differently in German transplant centers. Thus, the goal of the study was to learn more about how psychosocial evaluations are currently conducted in German transplant centers. Methods The psychosocial evaluators of the 38 transplant centers performing kidney transplantations in 2015 were contacted and asked to participate in an anonymous online survey. Results Psychosocial evaluators from 28 (75%) transplant centers responded. In only 30 (4%) of the evaluations contraindications for donation were reported. In most centers the psychosocial evaluation was performed after the completion of all medical tests. The evaluations were realized after only short waiting periods and were reported to be time-consuming. Financial reimbursement was mainly realized by internal cost allocation. In most centers the evaluators used semi-structured interviews. Still, there was limited consensus about structure and content of the psychosocial evaluation. Conclusion Standardization of the psychosocial evaluation process could be helpful to enable comparisons between transplant centers and to achieve equal opportunities for the potential living kidney donors and recipients. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Update of the BIPM comparison BIPM.RI(II)-K1.Co-60 of activity measurements of the radionuclide 60Co to include the 2011 result of the CNEA (Argentina), the 2012 results of the BARC (India) and the NRC (Canada), and the 2014 result of the NIM (China)

    Science.gov (United States)

    Michotte, C.; Ratel, G.; Courte, S.; Arenillas, P.; Balpardo, C.; Joseph, L.; Anuradha, R.; Kulkarni, D. B.; Galea, R.; Moore, K.; Stroak, A.; Zhang, Ming; Liang, Juncheng; Liu, Haoran

    2017-01-01

    Since 2010, four national metrology institutes (NMI) have each submitted a sample of known activity of 60Co to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Co-60. The values of the activity submitted were between about 175 kBq and 1600 kBq. The primary standardization results for the CNEA, Argentina and the BARC, India replace their earlier result of 2003 and 2001, respectively. There are now seventeen results in the BIPM.RI(II)-K1.Co-60 comparison. The key comparison reference value (KCRV) has been updated using the power-moderated weighted mean. The degrees of equivalence between each equivalent activity measured in the SIR and the KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  10. Particle Filtering Methods for Incorporating Intelligence Updates

    Science.gov (United States)

    2017-03-01

    appropriate information-updating mechanism. There exists a variety of ways to incorporate information updating. These methods include simple heuristics , such...threshold is preferable. It produces smoother results that are visibly more tractable. It eliminates a possible source of bias in the model by not

  11. Application of Student t-test for evaluation of interlaboratory comparative tests results

    Directory of Open Access Journals (Sweden)

    K. V. Shatalov

    2016-01-01

    Full Text Available The results of interlaboratory comparative tests typically represent a small sample size. Therefore, to evaluate the quality of test results of laboratories participating in interlaboratory comparative tests, it is proposed to use Student t-test, which connects three main characteristics of small sample: the width of the confidence interval, the corresponding confidence probability and sample size. The examples of interlaboratory comparative tests of diesel show, that the use Student test allows to more objectively evaluate the quality of tests results of laboratories, in particular to identify and assess the results outside the confidence interval of the certified value of the sample for inspection. The calculation of average values of Student statistic for the aggregate test results allows to evaluate the quality of the laboratory, to range them, to form a ranking of laboratories on an objective basis.

  12. The Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) update of the Finnish diabetes risk score for prediction of incident type 2 diabetes

    DEFF Research Database (Denmark)

    Alssema, M; Vistisen, D; Heymans, M W

    2011-01-01

    AIMS/HYPOTHESIS: The Finnish diabetes risk questionnaire is a widely used, simple tool for identification of those at risk for drug-treated type 2 diabetes. We updated the risk questionnaire by using clinically diagnosed and screen-detected type 2 diabetes instead of drug-treated diabetes...... as an endpoint and by considering additional predictors. METHODS: Data from 18,301 participants in studies of the Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) project with baseline and follow-up information on oral glucose tolerance status...... of the original Finnish risk questionnaire could be improved by adding information on sex, smoking and family history of diabetes. The DETECT-2 update of the Finnish diabetes risk questionnaire is an adequate and robust predictor for future screen-detected and clinically diagnosed type 2 diabetes in Europid...

  13. Clinical trial transparency update: an assessment of the disclosure of results of company-sponsored trials associated with new medicines approved in Europe in 2012.

    Science.gov (United States)

    Rawal, Bina; Deane, Bryan R

    2015-01-01

    The objective of this study was to assess the timely disclosure of results of company-sponsored clinical trials related to all new medicines approved by the European Medicines Agency (EMA) during 2012. This is an extension of the previously reported study of trials related to all new medicines approved in Europe in 2009, 2010 and 2011, which found that over three-quarters of all these trials were disclosed within 12 months and almost 90% were disclosed by the end of the study. The methodology used was exactly as previously reported. Various publicly available information sources were searched for both clinical trial registration and disclosure of results. All completed company-sponsored trials related to each new medicine approved for marketing by the EMA in 2012, carried out in patients and recorded on a clinical trials registry and/or included in an EMA European Public Assessment Report (EPAR), were included. Information sources were searched between 1 May and 31 July 2014. The main outcome measure was the proportion of trials for which results had been disclosed on a registry or in the scientific literature either within 12 months of the later of either first regulatory approval or trial completion, or by 31 July 2014 (end of survey). Of the completed trials associated with 23 new medicines licensed to 17 different companies in 2012, results of 90% (307/340) had been disclosed within 12 months, and results of 92% (312/340) had been disclosed by 31 July 2014. The disclosure rate within 12 months of 90% suggests the industry is now achieving disclosure in a timely manner more consistently than before. The overall disclosure rate at study end of 92% indicates that the improvement in transparency amongst company-sponsored trials has been maintained in the trials associated with new medicines approved in 2012.

  14. Clinical trial transparency update: an assessment of the disclosure of results of company-sponsored trials associated with new medicines approved in Europe in 2014.

    Science.gov (United States)

    Deane, Bryan R; Porkess, Sheuli

    2018-01-05

    The objective of this study was to assess the timely disclosure of results of company-sponsored clinical trials related to all new medicines approved by the European Medicines Agency (EMA) during 2014. This is the final extension of three previously reported studies of trials related to all new medicines approved in Europe in 2009, 2010 and 2011, and in 2012 and 2013. The original study found that over a three-year period over three-quarters of all trials were disclosed within 12 months and almost 90% were disclosed by the end of the study (31 January 2013). The extension studies (2012 and 2013 approvals) both showed an improvement in results disclosure within 12 months to 90%, and an overall disclosure rate of 92% and 93% respectively by the end of the studies. The methodology used was exactly as previously reported. Various publicly available information sources were searched for both clinical trial registration and disclosure of results. All completed company-sponsored trials related to each new medicine approved for marketing by the EMA in 2014, carried out in patients and recorded on a clinical trials registry and/or included in an EMA European Public Assessment Report (EPAR), were included. Information sources were searched between 1 May and 31 July 2016. The main outcome measure was the proportion of trials for which results had been disclosed on a registry or in the scientific literature either within 12 months of the later of either first regulatory approval or trial completion, or by 31 July 2016 (end of survey). Of the completed trials associated with 32 new medicines licensed to 22 different companies in 2014, results of 93% (505/542) had been disclosed within 12 months, and results of 96% (518/542) had been disclosed by 31 July 2016. The disclosure rate within 12 months of 93% suggests that industry is continuing to achieve disclosure in a timely manner. The overall disclosure rate at study end of 96% indicates that the improvement in transparency

  15. Clinical trial transparency update: an assessment of the disclosure of results of company-sponsored trials associated with new medicines approved in Europe in 2013.

    Science.gov (United States)

    Deane, Bryan R; Sivarajah, Jacintha

    2017-03-01

    The objective of this study was to assess the timely disclosure of results of company-sponsored clinical trials related to all new medicines approved by the European Medicines Agency (EMA) during 2013. This is an extension of two previously reported studies of trials related to all new medicines approved in Europe in 2009, 2010 and 2011, and in 2012. The original study found that over a three year period over three-quarters of all trials were disclosed within 12 months and almost 90% were disclosed by the end of the study. The extension study (2012 approvals) showed an improvement in results disclosure within 12 months to 90%, and an overall disclosure rate of 92% by the end of the study. The methodology used was exactly as previously reported. Various publicly available information sources were searched for both clinical trial registration and disclosure of results. All completed company-sponsored trials related to each new medicine approved for marketing by the EMA in 2013, carried out in patients and recorded on a clinical trials registry and/or included in an EMA European Public Assessment Report (EPAR), were included. Information sources were searched between 1 May and 31 July 2015. The main outcome measure was the proportion of trials for which results had been disclosed on a registry or in the scientific literature either within 12 months of the later of either first regulatory approval or trial completion, or by 31 July 2015 (end of survey). Of the completed trials associated with 34 new medicines licensed to 24 different companies in 2013, results of 90% (484/539) had been disclosed within 12 months, and results of 93% (500/539) had been disclosed by 31 July 2015. The disclosure rate within 12 months of 90% suggests that industry is continuing to achieve disclosure in a timely manner. The overall disclosure rate at study end of 93% indicates that the improvement in transparency amongst company-sponsored trials has been maintained in the trials associated

  16. Evaluating the Dynamics of Aircraft Crew Skill Development by Using the Results of Discrete Exercise Marking

    Directory of Open Access Journals (Sweden)

    Lešinskis Aloizs

    2017-08-01

    Full Text Available Aircraft crew training corresponds to the interactive learning models of sensorimotor skill acquisition, and the dynamics of skill acquirement can be approximated by the exponential trend. A model of 5-grade assessment of separate exercises is offered. It helps to calculate a resulting evaluation, in accordance with which the progress level of a discrete exercise is evaluated. Such an evaluation forms one of the points for the analytical construction of a learning curve using the Gaussian method. Possible applications of the learning curve are covered.

  17. PubRunner: A light-weight framework for updating text mining results [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Kishore R. Anekalla

    2017-10-01

    Full Text Available Biomedical text mining promises to assist biologists in quickly navigating the combined knowledge in their domain. This would allow improved understanding of the complex interactions within biological systems and faster hypothesis generation. New biomedical research articles are published daily and text mining tools are only as good as the corpus from which they work. Many text mining tools are underused because their results are static and do not reflect the constantly expanding knowledge in the field. In order for biomedical text mining to become an indispensable tool used by researchers, this problem must be addressed. To this end, we present PubRunner, a framework for regularly running text mining tools on the latest publications. PubRunner is lightweight, simple to use, and can be integrated with an existing text mining tool. The workflow involves downloading the latest abstracts from PubMed, executing a user-defined tool, pushing the resulting data to a public FTP or Zenodo dataset, and publicizing the location of these results on the public PubRunner website. We illustrate the use of this tool by re-running the commonly used word2vec tool on the latest PubMed abstracts to generate up-to-date word vector representations for the biomedical domain. This shows a proof of concept that we hope will encourage text mining developers to build tools that truly will aid biologists in exploring the latest publications.

  18. Updating representations of temporal intervals.

    Science.gov (United States)

    Danckert, James; Anderson, Britt

    2015-12-01

    Effectively engaging with the world depends on accurate representations of the regularities that make up that world-what we call mental models. The success of any mental model depends on the ability to adapt to changes-to 'update' the model. In prior work, we have shown that damage to the right hemisphere of the brain impairs the ability to update mental models across a range of tasks. Given the disparate nature of the tasks we have employed in this prior work (i.e. statistical learning, language acquisition, position priming, perceptual ambiguity, strategic game play), we propose that a cognitive module important for updating mental representations should be generic, in the sense that it is invoked across multiple cognitive and perceptual domains. To date, the majority of our tasks have been visual in nature. Given the ubiquity and import of temporal information in sensory experience, we examined the ability to build and update mental models of time. We had healthy individuals complete a temporal prediction task in which intervals were initially drawn from one temporal range before an unannounced switch to a different range of intervals. Separate groups had the second range of intervals switch to one that contained either longer or shorter intervals than the first range. Both groups showed significant positive correlations between perceptual and prediction accuracy. While each group updated mental models of temporal intervals, those exposed to shorter intervals did so more efficiently. Our results support the notion of generic capacity to update regularities in the environment-in this instance based on temporal information. The task developed here is well suited to investigations in neurological patients and in neuroimaging settings.

  19. Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results.

    Science.gov (United States)

    Yao, Kunhou; Hua, Long; Wei, Lunshou; Meng, Jiming; Hu, Junhong

    2015-11-01

    Genome-wide association studies (GWASs) and a number of case-control studies have suggested that several single nucleotide polymorphisms (SNPs), rs7837328, rs7014346, rs6983267, rs10505477 on CASC8 gene and rs4939827, rs4464148, rs12953717 on SMAD7 gene are significantly correlated with the susceptibility to colorectal cancer (CRC). For the sake of clarifying the association, a meta-analysis was conducted and population heterogeneity was considered in the study.A total of 34 articles including 90 studies (168,471 cases and 163,223 controls) that evaluated the relationship between the CASC8, SMAD7 genes and the risk of CRC under the allelic model were reviewed. Also subgroup analysis was performed by ethnicity (Caucasian, Asian, and African) and all of the analyses were implemented in R 3.2.1 software.Pooled data from the meta-analysis revealed that the A allele of rs7837328, the A allele of rs7014346, the G allele of rs6983267, the A allele of rs10505477, the T allele of rs4939827, the T of rs4464148, and the T of rs12953717 were significantly associated with an increased risk of CRC under the allelic model. Additionally, subgroup analyses of 6 SNPs by ethnicity (rs4464148 excepted) witnessed that the A allele of rs7837328, the G allele of rs6983267, and the T of rs12953717 were notably associated with an increased risk of CRC among Caucasian and Asian. Furthermore, the A allele of rs7014346, the A allele of rs10505477, and the T allele of rs4939827 were significantly related with an elevated risk of CRC only among Caucasian.Our study suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for CRC among both Caucasian and Asian whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasian. For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.

  20. Results of the global conservation assessment of the freshwater crabs (Brachyura, Pseudothelphusidae and Trichodactylidae: The Neotropical region, with an update on diversity

    Directory of Open Access Journals (Sweden)

    Neil Cumberlidge

    2014-11-01

    Full Text Available The freshwater crabs of the Neotropics comprise 311 species in two families (Pseudothelphusidae and Trichodactylidae and one or both of these families are found in all of the countries in the Neotropical region (except for Chile and some of the Caribbean islands. Colombia (102 species, 81% endemic and Mexico (67 species, 95% endemic are the biodiversity hotspots of freshwater crab species richness and country-level endemism for this region. The results of the IUCN Red List conservation assessments show that 34% of pseudothelphusids and 10% of trichodactylids have an elevated risk of extinction, 29% of pseudothelphusids and 75% of trichodactylids are not at-risk (Least Concern, and although none are actually extinct, 56% of pseudothelphusids and 17% of trichodactylids are too poorly known to assess (Data Deficient. Colombia (14 species, Venezuela (7 species, Mexico (6 species, and Ecuador (5 species are the countries with the highest number of threatened species of Neotropical freshwater crabs. The majority of threatened species are restricted-range semiterrestrial endemics living in habitats subjected to deforestation, alteration of drainage patterns, and pollution. This underlines the need to prioritize and develop conservation measures before species decline to levels from which they cannot recover. These results represent a baseline that can be used to design strategies to save threatened Neotropical species of freshwater crabs.

  1. UTILIZATION OF EVALUATION RESULTS IN LEGAL POLICY-MAKING AND ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Hellmut Wollmann

    2017-01-01

    Full Text Available The article is devoted to the analysis of evaluation method and its impact on legal policy development in governance, including in the area of law enforcement.The author outlines the importance of question whether, when and how the evaluation results of public policies, programs and measures has been utilized (or not utilized in policy making and policy implementation.In the pursuit of this guiding question the article will come in five steps.First, major variants of evaluation will be briefly presented particularly with an eye on their respective “utilization potential”.Second, different concepts will be sketched that have been forwarded to capture the utilization of social science generated knowledge by political, administrative and social actors. The author outlines a detailed description of types of evaluations: a retrospective, prelimi-nary, ongoing, interactive, – as well as existing concepts of application of its results.Third, looking at Germany, Switzerland and the European Union as “cases in point” perti-ent research findings will be discussed. The article also subjected to a detailed analysis of the experience of Germany, Switzerland and the European Union in the field of utilization of evaluation results.Fourth, a summary and conclusion will be given.Fifth, some remarks on pertinent research needs will be made.The author comes to the conclusion that that the rate of the utilization of evaluation-generated knowledge has so far turned out be, by and large, scarce. The author says that re-garding the politically crucial decisions the political rationality and its underlying political will of the decision-makers prevail while concerning less important decisions evaluation-generated evidence does show some effect and, hence, a dose of scientific rationality comes to the fore.There is also a need for further research on the subject of how should (and should not use assessment results when making legal and political decisions.

  2. A Statistical Description of the Types and Severities of Accidents Involving Tractor Semi-Trailers, Updated Results for 1992-1996

    Energy Technology Data Exchange (ETDEWEB)

    BLOWER,DANIEL F.; CLAUSS,DAVID B.

    1999-10-01

    This report provides a statistical description of the types and severities of tractor semi-trailer accidents involving at least one fatality. The data were developed for use in risk assessments of hazardous materials transportation. A previous study (SAND93-2580) reviewed the availability of accident data, identified the TIFA (Trucks Involved in Fatal Accidents) as the best source of accident data for accidents involving heavy trucks, and provided statistics on accident data collected between 1980 and 1990. The current study is an extension of the previous work and describes data collected for heavy truck accidents occurring between 1992 and 1996. The TIFA database created at the University of Michigan Transportation Research Institute was extensively utilized. Supplementary data on collision and fire severity, which was not available in the TIFA database, were obtained by reviewing police reports and interviewing responders and witnesses for selected TEA accidents. The results are described in terms of frequencies of different accident types and cumulative distribution functions for the peak contact velocity, rollover skid distance, effective fire temperature, fire size, fire separation, and fire duration.

  3. Flexible methods for segmentation evaluation: Results from CT-based luggage screening

    Science.gov (United States)

    Karimi, Seemeen; Jiang, Xiaoqian; Cosman, Pamela; Martz, Harry

    2017-01-01

    BACKGROUND Imaging systems used in aviation security include segmentation algorithms in an automatic threat recognition pipeline. The segmentation algorithms evolve in response to emerging threats and changing performance requirements. Analysis of segmentation algorithms’ behavior, including the nature of errors and feature recovery, facilitates their development. However, evaluation methods from the literature provide limited characterization of the segmentation algorithms. OBJECTIVE To develop segmentation evaluation methods that measure systematic errors such as oversegmentation and undersegmentation, outliers, and overall errors. The methods must measure feature recovery and allow us to prioritize segments. METHODS We developed two complementary evaluation methods using statistical techniques and information theory. We also created a semi-automatic method to define ground truth from 3D images. We applied our methods to evaluate five segmentation algorithms developed for CT luggage screening. We validated our methods with synthetic problems and an observer evaluation. RESULTS Both methods selected the same best segmentation algorithm. Human evaluation confirmed the findings. The measurement of systematic errors and prioritization helped in understanding the behavior of each segmentation algorithm. CONCLUSIONS Our evaluation methods allow us to measure and explain the accuracy of segmentation algorithms. PMID:24699346

  4. Angiofibroma juvenil de nasofaringe:: actualización de los resultados de la radioterapia Nasopharyngeal juvenile angiofribroma:: updating of radiotherapy results

    Directory of Open Access Journals (Sweden)

    José Alert Silva

    2010-03-01

    Full Text Available INTRODUCCIÓN. El angiofibroma juvenil de nasofaringe es un tumor benigno infrecuente, compuesto de tejido conectivo fibroso y abundancia de espacios vasculares revestidos de endotelio. Es casi exclusivo del sexo masculino y de la adolescencia. El tratamiento de elección es la exéresis, sin descartar otras posibilidades como la radioterapia. El objetivo del presente estudio fue presentar los resultados de esta última como opción terapéutica. MÉTODOS. Se estudió una serie de 11 pacientes, todos del sexo masculino, con edades entre 9 y 16 años, que fueron tratados en el Instituto Nacional de Oncología y Radiobiología de La Habana entre 1990 y 2005. Los pacientes fueron seguidos entre 48 y 306 meses. La radioterapia aplicada consistió en la irradiación de todo el volumen tumoral, con un margen de seguridad, en dosis de 40 a 60 Gy, con 1,8 Gy por sesión. Asociado a la radioterapia se utilizó interferón, durante y después de la irradiación, y poliquimioterapia en 1 paciente. RESULTADOS. Se obtuvo la remisión completa mantenida, sin recidivas, en 10 pacientes. No hubo pacientes con un segundo tumor. Presentaron complicaciones tempranas todos los pacientes, y tardías, solo algunos. Entre las complicaciones tempranas se halló radiomucositis y conjuntivis radiógena, y las más graves de las tardías fueron la pérdida permanente de las pestañas del párpado inferior en un caso y cataratas radiógenas en 4 pacientes. CONCLUSIONES. La radioterapia es un tratamiento que conserva su utilidad e indicaciones específicas.INTRODUCTION: The nasopharyngeal juvenile angiofribroma is a uncommon benign tumor composed of fibrous connective tissue and many vascular spaces covered by endothelium. It is almost exclusive of male sex and of adolescents. Choice treatment is the exeresis without obviate other possibilities as the radiotherapy. The aim of present study was to show the results of this latter as therapeutical option. METHODS: Authors

  5. Effectiveness of an educational intervention to improve child feeding practices and growth in rural China: updated results at 18 months of age.

    Science.gov (United States)

    Zhang, Jingxu; Shi, Ling; Chen, Da-Fang; Wang, Jing; Wang, Yan

    2013-01-01

    Inappropriate complementary feeding practices have led to, in part, significant disparities in growth and nutritional status between rural and urban children in China. A cluster-randomised, controlled trial was implemented in Laishui, China to assess the effectiveness of an educational intervention on caregivers' feeding practices and children's growth. Eight townships were randomly assigned to the intervention or control. Five hundred ninety-nine healthy infants were enrolled at 2-4 months old, and were followed up at ages 6, 9, 12, 15 and 18 months. The intervention group received information on enhanced home-prepared recipes and food preparation and hygiene through group training, counselling and home visit. Key outcomes were children's physical growth, caregivers' knowledge and behaviours on complementary feeding, and the infant and child feeding index (ICFI). Analysis was by intention to treat. The intervention group achieved better knowledge and practices related to complementary feeding, and significantly higher ICFI scores at each follow-up point. Children in the intervention group achieved higher z-scores for weight-for-age (WAZ) and weight-for-height (WHZ) than the control (0.18 vs. 0.01 and 0.49 vs. 0.19, respectively) at 18 months old, and were less likely to have stunted growth (odds ratio = 0.71, 95% confidence interval: 0.53-0.94). Mixed model showed that the intervention group achieved significantly better linear growth over time, including WAZ (P = 0.016), WHZ (P = 0.030) and HAZ (P = 0.078). These results indicated that an educational intervention delivered through local health services can enhance caregivers' knowledge and practices of complementary feeding and ultimately improve children's growth. © 2012 Blackwell Publishing Ltd.

  6. Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial.

    Science.gov (United States)

    Fokas, Emmanouil; Liersch, Torsten; Fietkau, Rainer; Hohenberger, Werner; Beissbarth, Tim; Hess, Clemens; Becker, Heinz; Ghadimi, Michael; Mrak, Karl; Merkel, Susanne; Raab, Hans-Rudolf; Sauer, Rolf; Wittekind, Christian; Rödel, Claus

    2014-05-20

    We previously described the prognostic impact of tumor regression grading (TRG) on the outcome of patients with rectal carcinoma treated with preoperative chemoradiotherapy (CRT) in the CAO/ARO/AIO-94 trial. Here we report long-term results after a median follow-up of 132 months. TRG after preoperative CRT was determined in 386 surgical specimens by the amount of viable tumor cells versus fibrosis, ranging from TRG 4 (no viable tumor cells) to TRG 0 (no signs of regression). Clinicopathologic parameters and TRG were correlated to the cumulative incidence of local recurrence, distant metastasis, and disease-free survival (DFS). Ten-year cumulative incidence of distant metastasis and DFS were 10.5% and 89.5% for patients with TRG 4 (complete regression), 29.3% and 73.6% for TRG 2 and 3 (intermediate regression), and 39.6% and 63% for TRG 0 and 1 (poor regression), respectively (P = .005 and P = .008, respectively). On multivariable analysis, residual lymph node metastasis (ypN+) and TRG were the only independent prognostic factors for cumulative incidence of distant metastasis (P < .001 and P = .035, respectively) and DFS (P < .001 and P = .039, respectively), whereas local recurrence was significantly affected by ypN status (P < .001) and lymphatic invasion (P = .026). Complete and intermediate tumor regressions were associated with improved long-term outcome in patients with rectal carcinoma after preoperative CRT independent of clinicopathologic parameters. This classification system needs to be prospectively tested in multiple data sets to validate its reproducibility in a wider setting. © 2014 by American Society of Clinical Oncology.

  7. Coagulation concepts update.

    Science.gov (United States)

    O'Connor, Stacy D; Taylor, Andrew J; Williams, Eliot C; Winter, Thomas C

    2009-12-01

    Since the previous comprehensive radiology review on coagulation concepts that was done in 1990, many studies have been published in the medical and surgical literature that can guide the approach of a radiology practice. The purpose of this article is to provide an analysis of these works, updating the radiologist on proper use and interpretation of coagulation assessment tools, medications that modify the hemostatic system, and the use of transfusions prior to interventions. The basic tools for coagulation assessment have not changed; however, results from subspecialty research have suggested ways in which the use of these tools can be modified and streamlined to safely reduce time and expense for the patient and the health care system.

  8. Process Evaluation Results from an Environmentally Focused Worksite Weight Management Study

    Science.gov (United States)

    DeJoy, David M.; Wilson, Mark G.; Padilla, Heather M.; Goetzel, Ron Z.; Parker, Kristin B.; Della, Lindsay J.; Roemer, Enid C.

    2012-01-01

    There is currently much interest in exploring environmental approaches to combat weight gain and obesity. This study presents process evaluation results from a workplace-based study that tested two levels of environmentally focused weight management interventions in a manufacturing setting. The moderate treatment featured a set of relatively…

  9. The Dutch Review Process for Evaluating the Quality of Psychological Tests: History, Procedure, and Results

    Science.gov (United States)

    Evers, Arne; Sijtsma, Klaas; Lucassen, Wouter; Meijer, Rob R.

    2010-01-01

    This article describes the 2009 revision of the Dutch Rating System for Test Quality and presents the results of test ratings from almost 30 years. The rating system evaluates the quality of a test on seven criteria: theoretical basis, quality of the testing materials, comprehensiveness of the manual, norms, reliability, construct validity, and…

  10. A System Evaluation Theory Analyzing Value and Results Chain for Institutional Accreditation in Oman

    Science.gov (United States)

    Paquibut, Rene Ymbong

    2017-01-01

    Purpose: This paper aims to apply the system evaluation theory (SET) to analyze the institutional quality standards of Oman Academic Accreditation Authority using the results chain and value chain tools. Design/methodology/approach: In systems thinking, the institutional standards are connected as input, process, output and feedback and leads to…

  11. Online Student Evaluation Improves Course Experience Questionnaire Results in a Physiotherapy Program

    Science.gov (United States)

    Tucker, Beatrice; Jones, Sue; Straker, Leon

    2008-01-01

    This paper reports the use of an online student evaluation system, Course Experience on the Web (CEW), in a physiotherapy program to improve their Course Experience Questionnaire (CEQ) results. CEW comprises a course survey instrument modeled on the CEQ and a tailored unit survey instrument. Closure of the feedback loop is integral in the CEW…

  12. Are Forecast Updates Progressive?

    NARCIS (Netherlands)

    C-L. Chang (Chia-Lin); Ph.H.B.F. Franses (Philip Hans); M.J. McAleer (Michael)

    2010-01-01

    textabstractMacro-economic forecasts typically involve both a model component, which is replicable, as well as intuition, which is non-replicable. Intuition is expert knowledge possessed by a forecaster. If forecast updates are progressive, forecast updates should become more accurate, on average,

  13. Are Forecast Updates Progressive?

    NARCIS (Netherlands)

    C-L. Chang (Chia-Lin); Ph.H.B.F. Franses (Philip Hans); M.J. McAleer (Michael)

    2013-01-01

    textabstractMany macroeconomic forecasts and forecast updates like those from IMF and OECD typically involve both a model component, which is replicable, as well as intuition, which is non-replicable. Intuition is expert knowledge possessed by a forecaster. If forecast updates are progressive,

  14. SOFT TISSUE RECONSTRUCTION OF THE LOWER EXTREMITY: EVALUATION OF SURGICAL RESULTS IN 15 PATIENTS

    OpenAIRE

    Fatemi, M.J.; M Baghaei; M Soroush

    2003-01-01

    Introduction: There are general guidelines for reconstruction of complex wounds of the Lower extremity. The goal in treatment of these wounds is to preserve a limb that will be more functional than an amputation. Material & Methods: In this study, we evaluate our results in 15 patients with extensive wounds in lower extremities (April - 1998 to march - 2001). Results: The average age of the patients was 31.20 with an age range between 9 to 61 years. Majority of the patients were...

  15. Methods for evaluation of medical care other than credentialing. Cost, experience, and results.

    Science.gov (United States)

    Ebert, P A

    1990-08-01

    Unfortunately, the majority of studies proposed to evaluate a physician's capabilities, such as effectiveness programs, outcome research, and hospital evaluation, do not focus directly on the individual practitioner. The certifying process, although imperfect, still offers the best method of evaluation. The other evaluation methods will need additional refinement to be able to individually analyze a specific physician's performance and determine whether he or she is truly providing the highest quality care. Physicians are being asked to document the effectiveness of their clinical decision making. On the surface this seems so simple, and in some areas where the outcome is either life or death or a specific yes or no type of answer, many have the capability to come forth with some realistic documentation. However, today's society is focused on health and the perfect outcome, and many nonlife-threatening therapies are evaluated by a patient's unrealistic expectation. Thus, the same result may be interpreted differently in one geographic area or by patients with different expectations. The biggest mistake would be to believe that outcome studies can be used to reduce cost. There may be some initial reduction or delays in treatment that suggest an immediate reduction of cost, the so-called sentinel effect, but no information or evidence indicates that these effects can be expanded without actually reducing needed health care services. In fact, the delays or obstruction to entering the health-care system experienced by many individuals often lead to more costly and less effective care with suboptimal results.

  16. Public library consumer health information pilot project: results of a National Library of Medicine evaluation.

    Science.gov (United States)

    Wood, F B; Lyon, B; Schell, M B; Kitendaugh, P; Cid, V H; Siegel, E R

    2000-10-01

    In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was

  17. Endoanal ultrasound evaluation of anorectal diseases and disorders: Technique, indications, results and limitations

    Energy Technology Data Exchange (ETDEWEB)

    Saranovic, Djordjije [University of Belgrade, Radiology Department, Institute for Digestive Diseases, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia)]. E-mail: crvzve4@yahoo.com; Barisic, Goran [Department for Colorectal Surgery, Institute for Digestive Disease, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia); Krivokapic, Zoran [Department for Colorectal Surgery, Institute for Digestive Disease, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia); Masulovic, Dragan [University of Belgrade, Radiology Department, Institute for Digestive Diseases, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia); Djuric-Stefanovic, Aleksandra [University of Belgrade, Radiology Department, Institute for Digestive Diseases, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia)

    2007-03-15

    Imaging of the rectum, anorectal junction and surrounding tissues is both difficult and technically challenging. CT and conventional barium studies offer limited information in local staging of rectal and perirectal neoplasms, anal carcinomas and extension perianal fistulas in patients with inflamamatory bowel disease, or in evaluating patients with fecal incontinence. During past decade, sonography and MR imaging have resulted in significant improvement in the imaging of rectal and perirectal and anal and perianal disease. The aim of this article is to review possibility of the EAUS in the evaluation both normal anal anatomy and anorectal disease and disorders (anal carcinoma, sphincter defects, anal fistulas, perianal abscesses and other pathological conditions)

  18. Statistical evaluation of characteristic SDDLV-induced stress resultants to discriminate between undamaged and damaged elements

    DEFF Research Database (Denmark)

    Hansen, Lasse Majgaard; Johansen, Rasmus Johan; Ulriksen, Martin Dalgaard

    2015-01-01

    alternately to an undamaged reference model with known stiffness matrix, hereby, theoretically, yielding characteristic stress resultants approaching zero in the damaged elements. At present, the discrimination between potentially damaged elements and undamaged ones is typically conducted on the basis...... of modified characteristic stress resultants, which are compared to a pre-defined tolerance value, without any thorough statistical evaluation. In the present paper, it is tested whether three widely-used statistical pattern-recognition-based damage-detection methods can provide an effective statistical...... evaluation of the characteristic stress resultants, hence facilitating general discrimination between damaged and undamaged elements. The three detection methods in question enable outlier analysis on the basis of, respectively, Euclidian distance, Hotelling’s statistics, and Mahalanobis distance. The study...

  19. Quantitative method for evaluation of aesthetic results after laser treatment for birthmarks.

    Science.gov (United States)

    Szychta, Pawel; Al-Nakib, Khalil; Anderson, Will; Stewart, Ken; Quaba, Awf

    2013-11-01

    Subjective assessment of results after laser treatment for birthmarks does not provide a validated method for clinicians. Previous reports concerning objective evaluation using L*a*b color coordinates were only partially successful due to difficulties in standardizing and comparing colors from pre- and posttreatment photographs. The study aimed to present a reliable and clinically applicable method of aesthetic result assessment after laser treatment for birthmarks. All 48 patients, included in the study, were treated for birthmarks on the face or neck using laser. Each pre- and posttreatment photograph was subjected to triple objective comparative assessment of color fading with use of a computer program, as well as to subjective evaluation by three core physicians and three laypeople. Objective analysis was based on an innovative method using combined L*a*b and hue saturation value color coordinates. Accuracy was higher between objective assessment with the computer program and subjective evaluation by core physicians than by laypeople. Repeatability of results was higher with the use of the computer program than among core physicians or among laypeople. In conclusion, our method may be considered for objective assessment of the results after laser treatment of vascular and pigmented birthmarks.

  20. Evaluating outcomes of palliative photodynamic therapy: instrument development and preliminary results

    Science.gov (United States)

    Goodell, Teresa T.; Bargo, Paulo R.; Jacques, Steven L.

    2002-06-01

    Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

  1. Can routine office-based audiometry predict cochlear implant evaluation results?

    Science.gov (United States)

    Gubbels, Samuel P; Gartrell, Brian C; Ploch, Jennifer L; Hanson, Kevin D

    2017-01-01

    Determining cochlear implant candidacy requires a specific sentence-level testing paradigm in best-aided conditions. Our objective was to determine if findings on routine audiometry could predict the results of a formal cochlear implant candidacy evaluation. We hypothesize that findings on routine audiometry will accurately predict cochlear implant evaluation results in the majority of candidates. Retrospective, observational, diagnostic study. The charts of all adult patients who were evaluated for implant candidacy at a tertiary care center from June 2008 through June 2013 were included. Routine, unaided audiologic measures (pure-tone hearing thresholds and recorded monosyllabic word recognition testing) were then correlated with best-aided sentence-level discrimination testing (using either the Hearing in Noise Test or AzBio sentences test). The degree of hearing loss at 250 to 4,000 Hz and monosyllabic word recognition scores significantly correlated with sentence-level word discrimination test results. Extrapolating from this association, we found that 86% of patients with monosyllabic word recognition scores at or below 32% (or 44% for patients with private insurance) would meet candidacy requirements for cochlear implantation. Routine audiometric findings can be used to identify patients who are likely to meet cochlear implant candidacy upon formal testing. For example, patients with pure-tone thresholds (250, 500, 1,000 Hz) of ≥75 dB and/or a monosyllabic word recognition test score of ≤40% have a high likelihood of meeting candidacy criteria. Utilization of these predictive patterns during routine audiometric evaluation may assist hearing health professionals in deciding when to refer patients for a formal cochlear implant evaluation. 4 Laryngoscope, 127:216-222, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  2. Audio segmentation of broadcast news in the Albayzin-2010 evaluation: overview, results, and discussion

    Directory of Open Access Journals (Sweden)

    Butko Taras

    2011-01-01

    Full Text Available Abstract Recently, audio segmentation has attracted research interest because of its usefulness in several applications like audio indexing and retrieval, subtitling, monitoring of acoustic scenes, etc. Moreover, a previous audio segmentation stage may be useful to improve the robustness of speech technologies like automatic speech recognition and speaker diarization. In this article, we present the evaluation of broadcast news audio segmentation systems carried out in the context of the Albayzín-2010 evaluation campaign. That evaluation consisted of segmenting audio from the 3/24 Catalan TV channel into five acoustic classes: music, speech, speech over music, speech over noise, and the other. The evaluation results displayed the difficulty of this segmentation task. In this article, after presenting the database and metric, as well as the feature extraction methods and segmentation techniques used by the submitted systems, the experimental results are analyzed and compared, with the aim of gaining an insight into the proposed solutions, and looking for directions which are promising.

  3. Evaluation and analysis of uncertainty in tensile experiment results of modified PPR at elevated temperature

    Science.gov (United States)

    Xiang, Yu; Zhonghua, Su; Jinhua, Leng; Teng, Yun

    2017-08-01

    A high temperature tensile experiment of modified random copolymerized polypropylene was carried out by ASTM D 638-2014. It analyzed the factors influencing the accuracy of the high temperature mechanical properties of modified random copolymer polypropylene and discussed the causes of the uncer-tainty of measurement standards from the sample size measurement, the indication error of force value of experiment machines, its calibration, data acquisition of the experimental software, the temperature control, the numerical correction, and the material nonuniformity, etc. According to JJF 1059.1-2012, class A and class B evaluation were conducted on the above-mentioned uncertainty components, and all the uncertainty components were synthesized. By analyzing the uncertainty of the measurement results, this paper provides a reference for evaluating the uncertainty of the same type of measurement results.

  4. Benchmarks and performance indicators: two tools for evaluating organizational results and continuous quality improvement efforts.

    Science.gov (United States)

    McKeon, T

    1996-04-01

    Benchmarks are tools that can be compared across companies and industries to measure process output. The key to benchmarking is understanding the composition of the benchmark and whether the benchmarks consist of homogeneous groupings. Performance measures expand the concept of benchmarking and cross organizational boundaries to include factors that are strategically important to organizational success. Incorporating performance measures into a balanced score card will provide a comprehensive tool to evaluate organizational results.

  5. Evaluation and comparison of clinical results of femoral fixation devices in arthroscopic anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Aydin, Deniz; Ozcan, Mert

    2016-03-01

    Several femoral fixation devices are available for hamstring tendon autograft in anterior cruciate ligament (ACL) reconstruction, but the best technique is debatable. We hypothesised that different suspensory femoral fixation techniques have no superiority over each other. The aim of this study was to evaluate and compare the clinical results of different suspensory femoral fixation devices in arthroscopic ACL reconstruction. This was a Level III, retrospective, comparative study. A total of 100 consecutive patients who underwent arthroscopic ACL reconstruction in a single institution with a mean follow-up time of 40 months (12-67 months) were divided into three groups according to femoral fixation devices as 'Endobutton' (n=34), 'Transfix' (n=35) and 'Aperfix' (n=31). The length of painful period after surgery, time to return to work and sporting activities, final range of motion, anterior drawer and Lachman tests, knee instability symptoms, International Knee Documentation Committee (IKDC) subjective knee evaluation score, Short Form 36 (SF-36) score, Lysholm knee score and Tegner point of the patients were evaluated and compared between groups. There were no significant differences between the groups. All techniques led to significant recovery in knee instability tests and symptoms. In this study, the clinical results of different suspensory femoral fixation techniques were found to be similar. We believe that different femoral fixation techniques have no effect on clinical results provided that the technique is correctly applied. The surgeon must choose a technique appropriate to his or her experience. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Follow the LEADER-Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results Trial.

    Science.gov (United States)

    Kalra, Sanjay

    2016-12-01

    This commentary analyzes the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial, which has reported the cardiovascular benefits of liraglutide. It places the results of this seminal trial in the context of the evolution of diabetes care, compares them with other recently published cardiovascular outcome trials, and suggests novel mechanisms to explain the benefits and properties of liraglutide. The editorial discusses the potential impact that LEADER will have on the prevention and management of diabetes and its vascular complications.

  7. A comprehensive performance evaluation on the prediction results of existing cooperative transcription factors identification algorithms.

    Science.gov (United States)

    Lai, Fu-Jou; Chang, Hong-Tsun; Huang, Yueh-Min; Wu, Wei-Sheng

    2014-01-01

    Eukaryotic transcriptional regulation is known to be highly connected through the networks of cooperative transcription factors (TFs). Measuring the cooperativity of TFs is helpful for understanding the biological relevance of these TFs in regulating genes. The recent advances in computational techniques led to various predictions of cooperative TF pairs in yeast. As each algorithm integrated different data resources and was developed based on different rationales, it possessed its own merit and claimed outperforming others. However, the claim was prone to subjectivity because each algorithm compared with only a few other algorithms and only used a small set of performance indices for comparison. This motivated us to propose a series of indices to objectively evaluate the prediction performance of existing algorithms. And based on the proposed performance indices, we conducted a comprehensive performance evaluation. We collected 14 sets of predicted cooperative TF pairs (PCTFPs) in yeast from 14 existing algorithms in the literature. Using the eight performance indices we adopted/proposed, the cooperativity of each PCTFP was measured and a ranking score according to the mean cooperativity of the set was given to each set of PCTFPs under evaluation for each performance index. It was seen that the ranking scores of a set of PCTFPs vary with different performance indices, implying that an algorithm used in predicting cooperative TF pairs is of strength somewhere but may be of weakness elsewhere. We finally made a comprehensive ranking for these 14 sets. The results showed that Wang J's study obtained the best performance evaluation on the prediction of cooperative TF pairs in yeast. In this study, we adopted/proposed eight performance indices to make a comprehensive performance evaluation on the prediction results of 14 existing cooperative TFs identification algorithms. Most importantly, these proposed indices can be easily applied to measure the performance of new

  8. Cervical Biopsy, Smear Evaluation and Comparison of Human Papilloma Virus Subtypes Result

    Directory of Open Access Journals (Sweden)

    Murat Arı

    2016-04-01

    Full Text Available Objective: The aim of this study was to investigate the relationship between human papilloma virüs (HPV types which was worked with polymerase chain reaction (PCR and immunohistochemistry methods and cvtology and biyopsy results. Materials and Methods: A total of 100 cases from hospital between 2010-2013 participitated in this study. Linear Array HPV genotyping test was worked with PCR, tissue biopsies was evaluated with light microscopy, HPV was detected with immunohistochemistry (IHK method and results were compared evaluating of conventional smear preparations according to Bethesda. Results: While 61 cases included high risk (61%, 39 cases included low risk HPV (39%. HPV types with high risk such as HPV16, HPV6, HPV11, HPV18, HPV31 respectively detected in 24, 19, 9, 7, 2 cases. HPV types with low risk such as HPV66 detected in 7 cases. HPV16 was observed epithelial cell abnormality such as 9 ASCUS, 3 LSIL,1 ASC-H, 1 AGUS in 14/24 ratio (58% and ILMAN was observed 10/24 ratio (42%. Between cytological diagnosis results and HPV types are significant relationship according to chi-square test (p=0.001. When the results of the biopsy tissue analyzed, 38 patients were diagnosed intraepithelial neoplasia and malignant, 62 cases were diagnosed inflammation and other benign featured. The relationship between tissue diagnosis and HPV types is significant according to chi-square test (p<0.001. HPV in tissue was positive in 44 cases. The relationship between HPV types and tissue HPV results are significant (p<0.001. The cytological tissue diagnosis of 19 patients with ASCUS has been reported as follows; 10 CIN1, 3 CIN2, 2 CIN3 and 4 inflammation. Negative and positive HPV results studied in tissue are not significant results with cytological diagnosis (p=0.02 and tissue diagnosis results (p=0.02. Conclusion: The important of HPV detection is obvious, but tissue changes as well as HPV detection are important. Thus combined use of testing, even in

  9. Evaluation of the results from non-arthroplastic treatment (arthroscopy) for shoulder arthrosis☆

    Science.gov (United States)

    Miyazaki, Alberto Naoki; Fregoneze, Marcelo; da Silva, Luciana Andrade; do Val Sella, Guilherme; Garotti, José Eduardo Rosseto; Checchia, Sergio Luiz

    2015-01-01

    Objectives To evaluate the functional results from patients with arthrosis who underwent an arthroscopic procedure, in an attempt to correlate these results with the patients’ epidemiological profile, surgical technique used, possible complications and postoperative protocol. Methods Between 1998 and 2011, 31 patients (32 shoulders) with shoulder arthrosis underwent arthroscopic treatment performed by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology of Santa Casa de São Paulo. Primary or secondary cases of shoulder arthrosis under the age of 70 years, in which the rotator cuff was intact, were included. Furthermore, cases in which, despite an indication for an arthroplastic procedure, an attempt to perform an alternative procedure had been chosen, were also included. The following were evaluated: sex, age, dominance, comorbidities, length of time with complaint, associated lesions, etiology, previous treatment, operation performed, postoperative protocol and pre and postoperative active ranges of motion. The functional evaluation was conducted using the UCLA criteria, before and after the operation. The joint cartilage alterations were classified in accordance with Outerbridge and the arthrosis by means of Walch. Results There were statistically significant mean differences in the values for elevation, lateral rotation and medial rotation from before to after the operation (p < 0.001) and there was a tendency (p = 0.057) toward poor results with greater length of time with complaints before the surgery. The total gain in UCLA score did not have any statistically significant relationship with any of the other variables analyzed. Conclusion Arthroscopic treatment of glenohumeral arthrosis provided functional improvement of the glenohumeral joint, with significant gains in elevation and lateral and medial rotation, and improvements in function and pain. Greater length of time with complaints was a factor strongly suggestive of

  10. Evaluation of the results from non-arthroplastic treatment (arthroscopy for shoulder arthrosis

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2015-08-01

    Full Text Available ABSTRACTOBJECTIVES: To evaluate the functional results from patients with arthrosis who underwent an arthroscopic procedure, in an attempt to correlate these results with the patients' epidemiological profile, surgical technique used, possible complications and postoperative protocol. METHODS: Between 1998 and 2011, 31 patients (32 shoulders with shoulder arthrosis underwent arthroscopic treatment performed by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology of Santa Casa de São Paulo. Primary or secondary cases of shoulder arthrosis under the age of 70 years, in which the rotator cuff was intact, were included. Furthermore, cases in which, despite an indication for an arthroplastic procedure, an attempt to perform an alternative procedure had been chosen, were also included. The following were evaluated: sex, age, dominance, comorbidities, length of time with complaint, associated lesions, etiology, previous treatment, operation performed, postoperative protocol and pre and postoperative active ranges of motion. The functional evaluation was conducted using the UCLA criteria, before and after the operation. The joint cartilage alterations were classified in accordance with Outerbridge and the arthrosis by means of Walch. RESULTS: There were statistically significant mean differences in the values for elevation, lateral rotation and medial rotation from before to after the operation ( p< 0.001 and there was a tendency ( p= 0.057 toward poor results with greater length of time with complaints before the surgery. The total gain in UCLA score did not have any statistically significant relationship with any of the other variables analyzed. CONCLUSION: Arthroscopic treatment of glenohumeral arthrosis provided functional improvement of the glenohumeral joint, with significant gains in elevation and lateral and medial rotation, and improvements in function and pain. Greater length of time with complaints was a factor

  11. Evaluating Behaviorally Oriented Aviation Maintenance Resource Management (MRM) Training and Programs: Methods, Results, and Conclusions

    Science.gov (United States)

    Taylor, James C.; Thomas, Robert L., III

    2003-01-01

    Assessment of the impact of Aviation Resource Management Programs on aviation culture and performance has compelled a considerable body of research (Taylor & Robertson, 1995; Taylor, 1998; Taylor & Patankar, 2001). In recent years new methods have been applied to the problem of maintenance error precipitated by factors such as the need for self-assessment of communication and trust. The present study - 2002 -- is an extension of that past work. This research project was designed as the conclusion of a larger effort to help understand, evaluate and validate the impact of Maintenance Resource Management (MRM) training programs, and other MRM interventions on participant attitudes, opinions, behaviors, and ultimately on enhanced safety performance. It includes research and development of evaluation methodology as well as examination of psychological constructs and correlates of maintainer performance. In particular, during 2002, three issues were addressed. First, the evaluation of two (independent & different) MRM programs for changing behaviors was undertaken. In one case we were able to further apply the approach to measuring written communication developed during 2001 (Taylor, 2002; Taylor & Thomas, 2003). Second, the MRM/TOQ surveys were made available for completion on the internet. The responses from these on-line surveys were automatically linked to a results calculator (like the one developed and described in Taylor, 2002) to aid industry users in analyzing and evaluating their local survey data on the internet. Third, the main trends and themes from our research about MRM programs over the past dozen years were reviewed.

  12. Airport surface moving map displays: OpEval-2 evaluation results and future plans

    Science.gov (United States)

    Livack, Garret; McDaniel, James I.; Battiste, Vernol

    2001-08-01

    The Federal Aviation Administration (FAA), in cooperation with the Cargo Airline Association (CAA) and three of its member airlines (Airborne Express, Federal Express, and United Parcel Service), have embarked upon an aggressive yet phased approach to introduce new Free Flight-enabling technologies into the U.S. National Airspace System (NAS). General aviation is also actively involved, represented primarily by the Aircraft Owners and Pilots Association (AOPA). These new technologies being evaluated include advanced cockpit avionics and a complimentary ground infrastructure. In support of this initiative, a series of operational evaluations (OpEvals) have been conducted or are planned. The OpEvals have evaluated in-flight as well as airport surface movement applications. Results from the second OpEval, conducted at Louisville, Kentucky in October 2000, indicated that runway incursions might be significantly reduced with the introduction of a cockpit-based moving map system derived from emerging technologies. An additional OpEval is planned to evaluate the utility of an integrated cockpit and airport surface architecture that provides enhanced pilot and controller awareness of airport surface operations. It is believed that the combination of such an airborne and a ground-based system best addresses many of the safety issues surrounding airport surface operations. Such a combined system would provide both flight crews and controllers with a common awareness, or shared picture of airport surface operations.

  13. IMS Learning Design Update

    NARCIS (Netherlands)

    Koper, Rob

    2004-01-01

    Presentation at the seminar: "Learning Designs in a Networked World: A Dutch - Canada Education Seminar". Organized by Terry Anderson at the University of Alberta, Edmonton, October 15th 2004. Contains update on activities around IMS LD.

  14. USDA Gin Lab Updates

    Science.gov (United States)

    This presentation provides an update to ginning industry stakeholders on current research efforts ongoing at the three USDA ARS ginning laboratories in Lubbock, TX, Stoneville, MS, and Mesilla Park, NM....

  15. Red Hill Updates

    Science.gov (United States)

    This and other periodic updates are intended to keep the public informed on major progress being made to protect public health and the environment at the Red Hill Underground Fuel Storage Facility in Hawaii.

  16. Results-Oriented Evaluations: Their Uses, Their Limits and How They are Driving Implementers‘ Coping Strategies

    Directory of Open Access Journals (Sweden)

    Michel Leroy

    2015-01-01

    Full Text Available While the use of monitoring and evaluation (M&E by media development implementers is well documented, organizations’ coping strategies to adapt to new environments in media and development still remain a relatively unexplored area. The article aims at showing how the theoretical lessons learnt by the industry have been put into practice and how a successful change can be driven within an organization using outside experts. A results-oriented culture of performance and service has been enforced since the 1990s in the EU. Evaluation systems have been a powerful catalyst in driving the transition from media support to media development and in making the latter more independent from broadcasters and donors. In recent years, changes in media assistance procedures and aims have profoundly modified the traditional landscape. This article will not question these changes, their origin and motivations. It will focus on implementers’ coping strategies to adapt (or not to these new procedures and aims and how results-oriented evaluations can drive the shift from outputs to outcomes in a changing media development sector. Can capitalizing on experience be considered a learning process that prepares for change and improves the design and implementation of projects? To what extent can it help to empower the operator as an organization? Referring to various concrete case studies from British, French and German media assistance, the article will focus on virtuous change – the circumstances that encourage structures, as well as donors who fund them, to better define and operationalize their strategies.

  17. Evaluation of the functional results after rotator cuff arthroscopic repair with the suture bridge technique

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    Full Text Available ABSTRACT OBJECTIVE: To evaluate the results of arthroscopic treatment of large and extensive rotator cuff injuries (RCI that involved the supra and infraspinatus muscles using the suture bridge (SB technique. METHODS: Between July 2010 and November 2014, 37 patients with RCI who were treated with SB technique were evaluated. The study included all patients with a minimum follow-up of 12 months who underwent primary surgery of the shoulder. Twenty-four patients were male and 13 were female. The mean age was 60 years (45-75. The dominant side was affected in 32 cases. The most common cause of injury was trauma (18 cases. The mean preoperative motion was 123°, 58°, T11. Through magnetic resonance imaging, 36 fatty degenerations were classified according to Goutallier. Patients underwent rotator cuff repair with SB technique, which consists of using a medial row anchor with two Corkscrew(r fibertape(r or fiberwire(r at the articular margin, associated with lateral fixation without stitch using PushLocks(r or SwiveLocks(r. RESULTS: The mean age was 60 years and mean fatty degeneration was 2.6. The mean range of motion (following the AAOS in the postoperative evaluation was 148° of forward elevation, 55° in lateral rotation and medial rotation in T9. Using the criteria of the University of California at Los Angeles (UCLA, 35 (94% patients had excellent and good results; one (2.7%, fair; and one (2.7%, poor. CONCLUSION: Arthroscopic repair of a large and extensive RCI using SB technique had good and excellent results in 94% of the patients.

  18. How you evaluate treatment results in low back pain patients depends on who the patient is

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2008-01-01

    How you evaluate treatment results in low back pain patients depends on who the patient is Lauridsen, HH 1*, Hartvigsen, J1,2, Manniche, C1,3, Korsholm, L1,4, Grunnet-Nilsson, N1 1.    Clinical Locomotion Science, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark...... pain subscales of the SF36, the Low Back Pain Rating Scale (LBPRS) and a numerical rating scale for pain (0-10) were completed by 191 patients from the primary and secondary sectors of the Danish health care system. Clinical change was estimated using a 7-point transition question and a numeric rating...... of an evaluative instrument in back pain patients is complicated because of lack of head-to-head comparisons of clinimetric properties of the various instruments. In addition, little is known about instrument behaviour in clinical subgroups. The objective of this study was to concurrently compare responsiveness...

  19. The delay effect on outcome evaluation: results from an Event-related Potential study

    Directory of Open Access Journals (Sweden)

    Chen eQu

    2013-11-01

    Full Text Available Behavioral studies demonstrate that the timing of receiving gains or losses affects decision-making, a phenomenon known as temporal discounting, as participants are inclined to prefer immediate rewards over delayed ones and vice versa for losses. The present study used the event-related potential (ERP technique with a simple gambling task to investigate how delayed rewards and losses affected the brain activity in outcome evaluations made by 20 young adults. Statistical analysis revealed a larger feedback related negativity (FRN effect between loss and gain following immediate outcomes than following future outcomes. In addition, delay impacted FRN only in gain conditions, with delayed winning eliciting a more negative FRN than immediatewinning. These results suggest that temporal discounting and sign effect could be encoded in the FRN in the early stage of outcome evaluation.

  20. Evaluation Criteria and Results of Full Scale Testing of Bridge Abutment Made from Reinforced Soil

    Science.gov (United States)

    Hildebrand, Maciej; Rybak, Jarosław

    2017-10-01

    Structures made of reinforced soil can be evaluated for their safety based on a load testing. Measurement results are essentially evaluated by displacements of surcharge (mainly in vertical direction) and facing elements (mainly in horizontal direction). Displacements are within several tenths to several millimetres and they can be taken by common geodetic equipment. Due to slow soil consolidation (progress of displacements) under constant load, observations should be made over several days or even weeks or months. A standard procedure of heating of geotextiles, used in laboratory conditions to simulate long term behaviour cannot be used in a natural scale. When the load is removed, the soil unloading occurs. Both the progress of displacements and soil unloading after unloading of the structure are the key presumptions for evaluating its safety (stability). Assessment of measuring results must be preceded by assuming even the simplest model of the structure, so as it could be possible to estimate the expected displacements under controlled load. In view of clearly random nature of soil parameters of retaining structure composed of reinforced soil and due to specific erection technology of reinforced soil structure, the assessment of its condition is largely based on expert’s judgment. It is an essential and difficult task to interpret very small displacements which are often enough disturbed by numerous factors like temperature, insolation, precipitation, vehicles, etc. In the presented paper, the authors tried to establish and juxtapose some criteria for a load test of a bridge abutment and evaluate their suitability for decision making. Final remarks are based on authors experience from a real full scale load test.

  1. Efficiency of Injection Therapy for Stress Incontinence: a Retrospective Evaluation of 8 Years Results

    Directory of Open Access Journals (Sweden)

    Kemal Ener

    2012-09-01

    Full Text Available Aim: To evaluate the long term affectivity of transurethral Calcium Hydroxylapatite (CaHA; Coaptite® injection therapy and the predictive importance of Body Mass Index (BMI, menopausal status and previous anti-incontinence surgery in selected female patients with stress urinary incontinence (SUI. Material and Method: Forty-five female patients with SUI, and having high risks for general anesthesia, received transurethal injection therapy, were evaluated retrospectively. First month, 12th month, and 8th year of post-injection period were evaluated in terms of International Consultatiton on Incontinence Questionnaire Short Form (ICIQ-SF, Quality of Life (QoL score, and pad test. Results: While the pad test of 1st and 12th months’ showed statistically significance, the pad test of last visit was found insignificant, when compared with pre-injection term. Through the evaluations of questionnaire forms similar to the pad test, it was observed that the post- injection scores showed statistically significance. However, unlike to the pad test, for each of both questionnaires, statistically significant differences were detected at the last examination’s scores, as well. When we examined the success of the transurethral injection treatment according to menopausal status, BMI, and previous anti-incontinence surgery, it was observed that QoL and ICIQ-SF score %variation, and 24 hr pad test values did not show any statistically significant differences at long term control, compared with the pre-injection term. Discussion: Transurethral injection is a cheap, easily performed and affective method for selected patients with SUI and BMI, previous anti-incontinence surgery, and menopausal status do not affect transurethral injection results at long term.

  2. Evaluation and perceived results of moral case deliberation: A mixed methods study.

    Science.gov (United States)

    Janssens, Rien M J P A; van Zadelhoff, Ezra; van Loo, Ger; Widdershoven, Guy A M; Molewijk, Bert A C

    2015-12-01

    Moral case deliberation is increasingly becoming part of various Dutch healthcare organizations. Although some evaluation studies of moral case deliberation have been carried out, research into the results of moral case deliberation within aged care is scarce. How did participants evaluate moral case deliberation? What has moral case deliberation brought to them? What has moral case deliberation contributed to care practice? Should moral case deliberation be further implemented and, if so, how? Quantitative analysis of a questionnaire study among participants of moral case deliberation, both caregivers and team leaders. Qualitative analysis of written answers to open questions, interview study and focus group meetings among caregivers and team leaders. Caregivers and team leaders in a large organization for aged care in the Netherlands. A total of 61 moral case deliberation sessions, carried out on 16 care locations belonging to the organization, were evaluated and perceived results were assessed. Participants gave informed consent and anonymity was guaranteed. In the Netherlands, the law does not prescribe independent ethical review by an Institutional Review Board for this kind of research among healthcare professionals. Moral case deliberation was evaluated positively by the participants. Content and atmosphere of moral case deliberation received high scores, while organizational issues regarding the moral case deliberation sessions scored lower and merit further attention. Respondents indicated that moral case deliberation has the potential to contribute to care practice as relationships among team members improve, more openness is experienced and more understanding for different perspectives is fostered. If moral case deliberation is to be successfully implemented, top-down approaches should go hand in hand with bottom-up approaches. The relevance of moral case deliberation for care practice received wide acknowledgement from the respondents. It can contribute

  3. Evaluating the Potential of NASA's Earth Science Research Results for Improving Future Operational Systems

    Science.gov (United States)

    Frederick, M. E.; Cox, E. L.; Friedl, L. A.

    2006-12-01

    NASA's Earth Science Theme is charged with implementing NASA Strategic Goal 3A to "study Earth from space to advance scientific understanding and meet societal needs." In the course of meeting this objective, NASA produces research results, such as scientific observatories, research models, advanced sensor and space system technology, data active archives and interoperability technology, high performance computing systems, and knowledge products. These research results have the potential to serve society beyond their intended purpose of answering pressing Earth system science questions. NASA's Applied Sciences Program systematically evaluates the potential of the portfolio of research results to serve society by conducting projects in partnership with regional/national scale operational partners with the statutory responsibility to inform decision makers. These projects address NASA's National Applications and the societal benefit areas under the IEOS and GEOSS. Prototyping methods are used in two ways in NASA's Applied Sciences Program. The first is part of the National Applications program element, referred to as Integrated Systems Solutions (ISS) projects. The approach for these projects is to use high fidelity prototypes to benchmark the assimilation of NASA research results into our partners' decision support systems. The outcome from ISS projects is a prototype system that has been rigorously tested with the partner to understand the scientific uncertainty and improved value of their modified system. In many cases, these completed prototypes are adopted or adapted for use by the operational partners. The second falls under the Crosscutting Solutions program element, referred to as Rapid Prototyping (RP) experiments. The approach for RP experiments is to use low fidelity prototypes that are low cost and quickly produced to evaluate the potential of the breadth of NASA research results to serve society. The outcome from the set of RP experiments is an

  4. Evaluation of the results from partial arthroplasty for treating shoulder osteoarthrosis

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2013-04-01

    Full Text Available OBJECTIVE: In this study we aim at statistically evaluating the results of the surgical treatment of the osteoarthrosis of the shoulder (OAS with partial shoulder arthroplasty (PSA and at correlating them with the several variables involved. METHODS: In this study we evaluated 36 shoulders of 31 patients with OAS who underwent treatment with PSA in the Grupo de Ombro e Cotovelo (Group of Shoulders and Elbows of the Department of Traumatology and Orthopedics of the Faculdade de Ciências Médicas da Santa Casa de São Paulo - Pavillion Fernandinho Simonsen between January, 1989 and November, 2010. Patients who underwent PSA and who had a post-operative follow-up of at least 12 months were included in the study. RESULTS: After the surgery the range of elevation, external rotation, internal rotation and the UCLA scale improved (with average differences of 35º, 27º, 4ºand 17 points, respectively, with a significant level of 5% (p < 0.05. For the same level of significance, the relation between a satisfactory UCLA and two variables was found: patients with maximum age of 60 years old at the moment of the surgery and patients that underwent tenotomy of the long head of biceps. CONCLUSION: Patients under 60 who underwent surgery and patients who underwent tenotomy of the long head of biceps achieved better results.

  5. Evaluation of NACA0012 airfoil test results in the NAL two-dimensional transonic wind tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Sudani, N.; Kanda, H.; Sato, M.; Miwa, H.; Matsuno, K.; Takanashi, S. [National Aerospace Laboratory, Tokyo (Japan)

    1991-05-01

    This paper describes a method with correction for the sidewall effects and the evaluation of the air foil test in the two-dimensional transonic wind tunnel. Surface pressure and drag measurements on the NACA0012 airfoil were conducted in the two-dimensional wind tunnel of National Aerospace Laboratory (NAL,Japan). Using a comparison with other wind tunnel data, the wall interference effects are discussed, especially those from the sidewall. The results suggest that the Mach number of the actual flow around the airfoil is lower than the setting Mach number. The Mach number correction for the sidewall boundary-layer effects based on the similarity rule was applied to the present measurements, thereby showing that the shock positions the pressure distributions, and the minimum drag coefficients are in good agreement with both other wind tunnel results and the Navier-Stokes calculation. It is shown that this correction method and the evaluation indicates satisfactory transonic airfoil test results in the NAL two-dimensional transonic wind tunnel. 10 refs., 11 figs., 1 tab.

  6. Evaluation of the functional results after rotator cuff arthroscopic repair with the suture bridge technique.

    Science.gov (United States)

    Miyazaki, Alberto Naoki; Santos, Pedro Doneux; Sella, Guilherme do Val; Checchia, Caio Santos; Salata, Thiago Roncoletta; Checchia, Sergio Luiz

    2017-01-01

    To evaluate the results of arthroscopic treatment of large and extensive rotator cuff injuries (RCI) that involved the supra and infraspinatus muscles using the suture bridge (SB) technique. Between July 2010 and November 2014, 37 patients with RCI who were treated with SB technique were evaluated. The study included all patients with a minimum follow-up of 12 months who underwent primary surgery of the shoulder. Twenty-four patients were male and 13 were female. The mean age was 60 years (45-75). The dominant side was affected in 32 cases. The most common cause of injury was trauma (18 cases). The mean preoperative motion was 123°, 58°, T11. Through magnetic resonance imaging, 36 fatty degenerations were classified according to Goutallier. Patients underwent rotator cuff repair with SB technique, which consists of using a medial row anchor with two Corkscrew(®) fibertape(®) or fiberwire(®) at the articular margin, associated with lateral fixation without stitch using PushLocks(®) or SwiveLocks(®). The mean age was 60 years and mean fatty degeneration was 2.6. The mean range of motion (following the AAOS) in the postoperative evaluation was 148° of forward elevation, 55° in lateral rotation and medial rotation in T9. Using the criteria of the University of California at Los Angeles (UCLA), 35 (94%) patients had excellent and good results; one (2.7%), fair; and one (2.7%), poor. Arthroscopic repair of a large and extensive RCI using SB technique had good and excellent results in 94% of the patients.

  7. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: First Results Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2011-03-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. This report provides the early data results and implementation experience of the AT fuel cell bus since it was placed in service.

  8. Quality of courses evaluated by 'predictions' rather than opinions: Fewer respondents needed for similar results.

    Science.gov (United States)

    Cohen-Schotanus, Janke; Schönrock-Adema, Johanna; Schmidt, Henk G

    2010-01-01

    A well-known problem with student surveys is a too low response rate. Experiences with predicting electoral outcomes, which required much smaller sample sizes, inspired us to adopt a similar approach to course evaluation. We expected that having respondents estimate the average opinions of their peers required fewer respondents for comparable outcomes than giving own opinions. Two course evaluation studies were performed among successive first-year medical students (N = 380 and 450, respectively). Study 1: Half the cohort gave opinions on nine questions, while the other half predicted the average outcomes. A prize was offered for the three best predictions (motivational remedy). Study 2: Half the cohort gave opinions, a quarter made predictions without a prize and a quarter made predictions with previous year's results as prior knowledge (cognitive remedy). The numbers of respondents required for stable outcomes were determined following an iterative process. Differences between numbers of respondents required and between average scores were analysed with ANOVA. In both studies, the prediction conditions required significantly fewer respondents (p < 0.001) for comparable outcomes. The informed prediction condition required the fewest respondents (N < 20). Problems with response rates can be reduced by asking respondents to predict evaluation outcomes rather than giving opinions.

  9. Ultrasound functional evaluation of fetuses with myelomeningocele: study of the interpretation of results.

    Science.gov (United States)

    Maroto, A; Illescas, T; Meléndez, M; Arévalo, S; Rodó, C; Peiró, J L; Belfort, M; Cuxart, A; Carreras, E

    2017-10-01

    To assess the reliability of the interpretation of a new technique for the ultrasound evaluation of the level of neurological lesion in fetuses with myelomeningocele. Observational study including myelomeningocele fetuses, referred to our center for the sonographic assessment of the fetal lower-limb movements, made and recorded by an expert in Maternal-fetal medicine and a specialist in Rehabilitation. Two observers, with different levels of expertise and blinded to each other's results, interpreted each recorded scan two different times. The agreement for the segmental levels assigned between the observers and the gold standard, the inter-observer and intra-observer reproducibility were tested using the weighed Kappa (wκ) index. Twenty-eight scans were recorded and evaluated. The agreement between the observers and the gold standard remained constant for the expert observer (wκ = 0.82) and increased (wκ = 0.66-wκ = 0.72) for the other one. The inter-observer and the intra-observer variability for the expert observer were wκ = 0.72 and wκ = 0.94, respectively. The agreement for the prenatal evaluation of the segmental neurological level was excellent, after a short training period, for observers with different degrees of expertise. The interpretation of this technique is reproducible enough and this supports its value for the prediction of postnatal motor function in myelomeningocele fetuses.

  10. Central washout sign in computer-aided evaluation of breast MRI: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Eun Sook (Dept. of Radiology, Samsung Medical Center, Sungkyunkwan Univ. School of Medicine, Seoul (Korea, Republic of)), e-mail: mathilda0330@gmail.com; Choi, Hye Young (Dept. of Radiology, Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)); Lee, Byung Hee (Dept. of Radiology, Korea Cancer Centre Hospital, Seoul (Korea, Republic of)); Noh, Woo-Chul (Dept. of Surgery, Korea Cancer Centre Hospital, Seoul (Korea, Republic of)); Kim, Rock Bum (Dept. of Preventive Medicine, Gyeongsang National Univ., Jinju (Korea, Republic of))

    2011-04-15

    Background: Although computer-aided evaluation (CAE) programs were introduced to help differentiate benign tumors from malignant ones, the set of CAE-measured parameters that best predict malignancy have not yet been established. Purpose: To assess the value of the central washout sign on CAE color overlay images of breast MRI. Material and Methods: We evaluated the frequency of the central washout sign using CAE. The central washout sign was determined so that thin, rim-like, persistent kinetics were seen in the periphery of the tumor. Then, sequentially, plateau and washout kinetics appeared. Two additional CAE-delayed kinetic variables were compared with the central washout sign for assessment of diagnostic utility: the predominant enhancement type (washout, plateau, or persistent) and the most suspicious enhancement type (any washout > any plateau > any persistent kinetics). Results: One hundred and forty-nine pathologically proven breast lesions (130 malignant, 19 benign) were evaluated. A central washout sign was associated with 87% of malignant lesions but only 11% of benign lesions. Significant differences were found when delayed-phase kinetics were categorized by the most suspicious enhancement type (P< 0.001) and the presence of the central washout sign (P< 0.001). Under the criteria of the most suspicious kinetics, 68% of benign lesions were assigned as plateau or washout pattern. Conclusion: The central washout sign is a reliable indicator of malignancy on CAE color overlay images of breast MRI

  11. EVALUATION OF ECOLOGICAL EFFICIENCY RESULTING FROM THE APPLICATION OF MODERN BUSES IN URBAN COMMUNICATIONS

    Directory of Open Access Journals (Sweden)

    Halina Marczak

    2017-09-01

    Full Text Available The use of modern vehicles may contribute to limiting the adverse impact of urban transport on the environment. Evaluation of options for choosing new means of transport in terms of economic and ecological benefits allows for the identification of the most advantageous variants. The solution is to consider replacing a bus compliant with a Euro III norm (base variant with a bus compliant with Euro VI (option 1 or with an electric bus (option 2. The evaluation of the solutions was based on the calculated parameters: a monetary value reflecting the energy cost of the analyzed buses and the ecological effect of the reduced emissions from the Euro VI bus and the electric bus compared with the Euro III vehicle. The ecological effect resulting from the use of the electric bus was determined taking into account emissions from fossil fuels (coal, natural gas and biomass. The method of cost analysis was used to evaluate the solution of replacing older buses with new ones (with different types of propulsion. It is based on calculating the unit cost of achieving the ecological effect of the solution.

  12. Process evaluation results of a cluster randomised controlled childhood obesity prevention trial: the WAVES study

    Directory of Open Access Journals (Sweden)

    T. L. Griffin

    2017-08-01

    Full Text Available Abstract Background Increasing prevalence of childhood obesity and its related consequences emphasises the importance of developing and evaluating interventions aimed at prevention. The importance of process evaluation in health intervention research is increasingly recognised, assessing implementation and participant response, and how these may relate to intervention success or failure. A comprehensive process evaluation was designed and undertaken for the West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES study that tested the effectiveness of an obesity prevention programme for children aged 6-7 years, delivered in 24 UK schools. The four intervention components were: additional daily school-time physical activity (PA; cooking workshops for children and parents; Villa Vitality (VV, a 6-week healthy lifestyle promotion programme run by a local football club; and signposting to local PA opportunities. Methods Data relating to six dimensions (Fidelity, Reach, Recruitment, Quality, Participant Responsiveness, Context were collected via questionnaires, logbooks, direct observations, focus groups and interviews. Multiple data collection methods allowed for data triangulation and validation of methods, comparing research observations with teacher records. The 6-stage WAVES study model ((i Data collection, (ii Collation, (iii Tabulation, (iv Score allocation and discussion, (v Consultation, (vi Final score allocation was developed to guide the collection, assimilation and analysis of process evaluation data. Two researchers independently allocated school scores on a 5-point Likert scale for each process evaluation dimension. Researchers then discussed school score allocations and reached a consensus. Schools were ranked by total score, and grouped to reflect low, medium or high intervention implementation. Results The intervention was predominantly well-implemented and well-received by teachers, parents and children. The PA

  13. A prospective evaluation of zirconia posterior fixed dental prostheses: three-year clinical results.

    Science.gov (United States)

    Peláez, Jesus; Cogolludo, Pablo G; Serrano, Benjamin; Lozano, Jose F L; Suárez, Maria J

    2012-06-01

    Although the favorable mechanical properties of zirconium oxide-based ceramics have increased the acceptance of fixed dental prostheses for use in the posterior regions of the mouth in recent years, there are few clinical studies documenting the longevity of these restorations. Furthermore, certain complications must be resolved before the material is used more extensively. The purpose of this randomized prospective study was to evaluate the clinical performance of zirconia (Lava) 3-unit posterior fixed dental prostheses. Twenty 3-unit fixed dental prostheses were placed in 17 participants to replace a second premolar or a first molar. Eleven were placed in the maxilla and 9 in the mandible. All abutment teeth were prepared with a chamfer finish line of 0.8 to 1 mm, and frameworks were prepared with the Lava system. Restorations were cemented with a resin cement. Two calibrated examiners independently evaluated the fixed dental prostheses 1 week (baseline) and 1, 2, and 3 years after placement with the California Dental Association quality evaluation system. The periodontal parameters: the gingival index, plaque index, margin index, and the probing depths of abutment teeth and contralateral teeth were assessed. Data were analyzed by using descriptive statistics and the Wilcoxon signed-rank test (α=.05). All fixed dental prostheses were rated satisfactory after 3 years, and no fracture of the framework was observed during the observation period. One fixed dental prostheses was lost because of a biological complication at the 3-year examination, and a small degree of chipping of the veneering ceramic was observed in 2 participants. No significant differences among the periodontal parameters of the test and control teeth were observed except for the margin index. The results of a 3-year evaluation suggest that posterior zirconia 3-unit fixed dental prostheses are a reliable treatment. Copyright © 2012 The Editorial Council of the Journal of Prosthetic Dentistry

  14. Cushing syndrome: update on testing.

    Science.gov (United States)

    Raff, Hershel

    2015-03-01

    Endogenous hypercortisolism (Cushing syndrome) is one of the most enigmatic diseases in clinical medicine. The diagnosis and differential diagnosis of Cushing syndrome depend on proper laboratory evaluation. In this review, an update is provided on selected critical issues in the diagnosis and differential diagnosis of Cushing syndrome: the use of late-night salivary cortisol in initial diagnosis and for postoperative surveillance, and the use of prolactin measurement to improve the performance of inferior petrosal sinus sampling to distinguish Cushing disease from ectopic adrenocorticotropic hormone (ACTH) syndrome during differential diagnosis of ACTH-dependent Cushing syndrome. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Los Alamos Climatology 2016 Update

    Energy Technology Data Exchange (ETDEWEB)

    Bruggeman, David Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-10

    The Los Alamos National Laboratory (LANL or the Laboratory) operates a meteorology monitoring network to support LANL emergency response, engineering designs, environmental compliance, environmental assessments, safety evaluations, weather forecasting, environmental monitoring, research programs, and environmental restoration. Weather data has been collected in Los Alamos since 1910. Bowen (1990) provided climate statistics (temperature and precipitation) for the 1961– 1990 averaging period, and included other analyses (e.g., wind and relative humidity) based on the available station locations and time periods. This report provides an update to the 1990 publication Los Alamos Climatology (Bowen 1990).

  16. Window Update Patterns in Stream Operators

    Science.gov (United States)

    Patroumpas, Kostas; Sellis, Timos

    Continuous queries applied over nonterminating data streams usually specify windows in order to obtain an evolving -yet restricted- set of tuples and thus provide timely results. Among other typical variants, sliding windows are mostly employed in stream processing engines and several advanced techniques have been suggested for their incremental evaluation. In this paper, we set out to study the existence of monotonic-related semantics in windowing constructs towards a more efficient maintenance of their changing contents. We investigate update patterns observed in common window variants as well as their impact on windowed adaptations of typical operators (like selection, join or aggregation), offering more insight towards design and implementation of stream processing mechanisms. Finally, to demonstrate its significance, this framework is validated for several windowed operations against streaming datasets with simulations at diverse arrival rates and window sizes.

  17. Developing a conceptual approach for regional climate model evaluation: initial results

    Science.gov (United States)

    di Luca, A.; de Elía, R.; Laprise, R.

    2009-12-01

    Regional Climate Models (RCMs) are tools now commonly used for producing high-resolution simulations of present climate and of future climate change projections. One of the most elusive issues in regional climate modeling is model evaluation, not only due to a sparseness of climate observations but also because of the intrinsic complexities of this task. One important difficulty in model evaluation is that models may sometimes produce the right results for the wrong reason. For example, an RCM may properly simulate the daily average temperature over a given region, but this maybe the consequence of compensating errors. In the case of an RCM that produces excessive cloudiness, cooler days (i.e., negative bias) and warmer nights (i.e., positive bias) than observed are usually the net effects, but both bias compensate to produce a daily average temperature close to the observed one. The question that we would like to investigate in this research is directly linked to this issue: under what conditions are we to accept model results as good? The starting point in order to tackle this challenging issue is to suggest a definition of “model goodness". Following ideas borrowed from epistemology and logic, we may define that a model result is good, if it remains good "under all possible refinements". In this context, the term “refinement” can be understood as an increasingly detailed inspection of model results that may help to unmask good results brought by a compensation of errors. The specifics of how a refinement may work will be explained by describing the particular case of time-scale refinement. Consider a time series of hourly precipitation in a given region. The evaluation of the model may start, and usually does, by assessing the simulation of seasonal or monthly mean values against observed data (e.g., the annual cycle). Once these values have proven to be relatively well simulated, the evaluation can go on with the analysis of simulated precipitation

  18. Lecturers’ Commitment And Students’ Academic Achievement: Case Study From Existing Teaching Evaluation Result (TER

    Directory of Open Access Journals (Sweden)

    Tengku Noorainun Tengku Shahdan

    2012-09-01

    Full Text Available This study reported herein is the used of TER as the basis to ascertain if the commitment of the lecturers can lead to academic excellence of the students.  The TER is comprised of questionnaires in which the foundation students are the respondents (N=433 in assessing the courses as well as the lecturers.  The performances of the students in the form of final exam grades are also used. The respondents were comprised of 85% Indian, 10% Malay and 5% Chinese.  There are more than 30% of the students who have obtained a grade of A- and better, the TER was < 80%.  Due to the limitation and the unavailability of matching each student to their evaluation towards the lecturers, the results presented above is weakly conclusive. It is recommended that future research in similar areas to incorporate the matching of students be made with the lecturers to obtain reliable and conclusive result.

  19. Evaluation of Variability in Resilient Modulus Test Results (ASTM D4123)

    Science.gov (United States)

    1989-10-01

    Samples of asphalt mixture were evaluated in the laboratory under various conditions to evaluate the repeatability of the resilient modulus test and to evaluate the effect of stress on the measured resilient modulus. Some of the samples were prepared...

  20. Evaluation of the results from surgical treatment of the terrible triad of the elbow,

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2014-06-01

    Full Text Available OBJECTIVE: to evaluate the results from surgical treatment of the terrible triad of the elbow (fracture of the radial head, fracture of the coronoid process and elbow dislocation and its complications.METHODS: between August 2002 and August 2010, 15 patients (15 elbows with the terrible triad were treated by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology, School of Medical Sciences, Santa Casa de São Paulo. Nine (60% were male and six (40% were female; their ages ranged from 21 to 66 years, with a mean of 41 years. With the exception of one case that underwent arthroscopic surgery, all the patients underwent open surgery. The fracture of the coronoid process was fixed in 10 patients (66.7%. The fracture of the radial head was treated by means of internal osteosynthesis in 11 cases (73.3%; in three cases (20%, the radial head was resected; and in one case, only the fragment of the fracture was resected. The collateral ligaments, except for one case, were repaired whenever they were found to be injured; ten cases (66.7% of medial collateral injury and 15 (100% of lateral collateral injury were found. The mean length of the postoperative follow-up was 62 months, with a minimum of 12 months. The postoperative evaluation was done by means of the Bruce score.RESULTS: more than 80% of the patients recovered their functional ranges of motion but, according to the Bruce score, only 26% of the patients achieved results that were considered satisfactory.CONCLUSION: despite the unsatisfactory results, the functional ranges of motion and elbow function could be restored.

  1. Investing in updating: how do conclusions change when Cochrane systematic reviews are updated?

    Directory of Open Access Journals (Sweden)

    McKenzie Joanne E

    2005-10-01

    Full Text Available Abstract Background Cochrane systematic reviews aim to provide readers with the most up-to-date evidence on the effects of healthcare interventions. The policy of updating Cochrane reviews every two years consumes valuable time and resources and may not be appropriate for all reviews. The objective of this study was to examine the effect of updating Cochrane systematic reviews over a four year period. Methods This descriptive study examined all completed systematic reviews in the Cochrane Database of Systematic Reviews (CDSR Issue 2, 1998. The latest version of each of these reviews was then identified in CDSR Issue 2, 2002 and changes in the review were described. For reviews that were updated within this time period and had additional studies, we determined whether their conclusion had changed and if there were factors that were predictive of this change. Results A total of 377 complete reviews were published in CDSR Issue 2, 1998. In Issue 2, 2002, 14 of these reviews were withdrawn and one was split, leaving 362 reviews to examine for the purpose of this study. Of these reviews, 254 (70% were updated. Of these updated reviews, 23 (9% had a change in conclusion. Both an increase in precision and a change in statistical significance of the primary outcome were predictive of a change in conclusion of the review. Conclusion The concerns around a lack of updating for some reviews may not be justified considering the small proportion of updated reviews that resulted in a changed conclusion. A priority-setting approach to the updating of Cochrane systematic reviews may be more appropriate than a time-based approach. Updating all reviews as frequently as every two years may not be necessary, however some reviews may need to be updated more often than every two years.

  2. Update on Vascular Dementia.

    Science.gov (United States)

    Khan, Ayesha; Kalaria, Raj N; Corbett, Anne; Ballard, Clive

    2016-09-01

    Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory caused by impaired blood flow to the brain and damage to the blood vessels resulting from events such as stroke. There are a variety of etiologies that contribute to the development of vascular cognitive impairment and VaD, and these are often associated with other dementia-related pathologies such as Alzheimer disease. The diagnosis of VaD is difficult due to the number and types of lesions and their locations in the brain. Factors that increase the risk of vascular diseases such as stroke, high blood pressure, high cholesterol, and smoking also raise the risk of VaD. Therefore, controlling these risk factors can help lower the chances of developing VaD. This update describes the subtypes of VaD, with details of their complex presentation, associated pathological lesions, and issues with diagnosis, prevention, and treatment. © The Author(s) 2016.

  3. Weighting of items in a tutorial performance evaluation instrument: Statistical analysis and results

    Directory of Open Access Journals (Sweden)

    Piet J. Becker

    2009-04-01

    Full Text Available Weighting of items in an evaluation instrument contributes to more meaningful and valid interpretations of student performance in respect of each learning outcome or item being assessed. It follows that the validity of instruments is important for meaningful inferences about students’ learning performance, including their performance in tutorial groups. The Delphi technique was used to elicit experts’ subjective judgement of the content validity of items in the tutorial performance evaluation instrument in rounds one and two. A sample of eight experts (n = 8 was selected by purposive, maximum variation sampling.

    In round three Delphi a weighted score was determined for each of the instrument items, subitems and Likert scale points through pairwise comparison by the experts. Mathematical modelling of experts’ weighting comparisons, recorded on visual analogue scales, resulted in proportional weights for each item; these weights are expressed as a percentage.

    The final instrument comprised weighted items measured on a rating scale with points that are not equidistant. A computerised tutorial performance evaluator (TPE was developed for accurate, economical and efficient calculation of student scores. The purpose of this article is to report on the statistical analysis and results of the weighting of items in an instrument to assess and evaluate baccalaureate nursing students’ performance in problem-based learning tutorials.

    Opsomming

    Die waardebepaling van items in ‘n evalueringsinstrument dra by tot ‘n meer betekenisvolle en geldige interpretasie van studente se vermoë ten opsigte van elke leeruitkoms of item wat geassesseer word. Hieruit volg dit dat die geldigheid van instrumente belangrik is vir betekenisvolleafleidings betreffende studente se leervermoë, insluitend hulle prestasie in leergroepe. Die Delphi-tegniek is gebruik in rondtes een en twee om kundiges se subjektiewe oordeel oor die

  4. Updated prevalence rates of overweight and obesity in 4- to 10-year-old children in Germany. Results from the telephone-based KiGGS Wave 1 after correction for bias in parental reports.

    Science.gov (United States)

    Brettschneider, Anna-Kristin; Schienkiewitz, Anja; Schmidt, Steffen; Ellert, Ute; Kurth, Bärbel-Maria

    2017-04-01

    The nationwide 'German Health Interview and Examination Survey for Children and Adolescents' (KiGGS), conducted in 2003-2006, showed an increase in the prevalence rates of overweight and obesity compared to the early 1990s, indicating the need for regular monitoring. Recently, a follow-up-KiGGS Wave 1 (2009-2012)-was carried out as a telephone-based survey, providing parent-reported height and weight from 5155 children aged 4-10 years. Since parental reports lead to a bias in prevalence rates of weight status, a correction is needed. From a subsample of KiGGS Wave 1 participants, measurements for height and weight were collected in a physical examination. In order to correct prevalence rates derived from parent reports, weight status categories based on parent-reported and measured height and weight were used to estimate a correction formula according to an established procedure. The corrected prevalence rates derived from KiGGS Wave 1 for overweight, including obesity, in children aged 4-10 years in Germany showed that stagnation is reached compared to the KiGGS baseline study (2003-2006). The rates for overweight, including obesity, in Germany have levelled off. However, they still remain at a high level, indicating a need for further public health action. What is Known: • In the last decades, prevalence of overweight and obesity has risen. Now a days, the prevalence seems to be stagnating. • In Germany, prevalence estimates of overweight and obesity are only available from regional or non-representative studies. What is New: • This article gives an update for prevalence rates of overweight and obesity amongst children aged 4-10 years in Germany based on a nationwide and representative sample. • Results show that stagnation in prevalence rates for overweight in children in Germany is reached.

  5. Dutch Venous Ulcer guideline update.

    Science.gov (United States)

    Maessen-Visch, M Birgitte; de Roos, Kees-Peter

    2014-05-01

    The revised guideline of 2013 is an update of the 2005 guideline "venous leg ulcer". In this special project four separate guidelines (venous leg ulcer, varicose veins, compression therapy and deep venous disorders) were revised and developed simultaneously. A meeting was held including representatives of any organisation involved in venous disease management including patient organizations and health insurance companies. Eighteen clinical questions where defined, and a new strategy was used to accelerate the process. This resulted in two new and two revised guidelines within one year. The guideline committee advises use of the C of the CEAP classification as well as the Venous Clinical Severity Score (VCSS) and a Quality of life (QoL) score in the assessment of clinical signs. These can provide insight into the burden of disease and the effects of treatment as experienced by the patient. A duplex ultrasound should be performed in every patient to establish the underlying aetiology and to evaluate the need for treatment (which is discussed in a separate guideline). The use of the TIME model for describing venous ulcers is recommended. There is no evidence for antiseptic or antibiotic wound care products except for a Cochrane review in which some evidence is presented for cadexomer iodine. Signs of infection are the main reason for the use of oral antibiotics. When the ulcer fails to heal the use of oral aspirin and pentoxifylline can be considered as an adjunct. For the individual patient, the following aspects should be considered: the appearance of the ulcer (amount of exudate) according to the TIME model, the influence of wound care products on moisturising the wound, frequency of changing compression bandages, pain and allergies. The cost of the dressings should also be considered. Education and training of patients t improves compliance with compression therapy but does not influence wound healing rates. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  6. Preoperative evaluation, surgical procedure, follow up and results of 150 cochlear implantations.

    Science.gov (United States)

    Kyriafinis, G; Vital, V; Psifidis, A; Constantinidis, J; Nikolaou, A; Hitoglou-Antoniadou, M; Kouloulas, A

    2007-04-01

    The cochlear implantation is among the most important achievements of medicine and biotechnology in the last 20 years, because it allows individuals who had never heard or had lost their hearing to perceive sound and improve their quality of life. Selection criteria for candidates are strict and are evaluated in each individual by a scientific committee specially trained for implantations which includes Ear Nose and Throat (ENT) surgeon, audiologist, psychiatrist and speech therapist. In our department, the first cochlear implantation was performed in 1995. During the last ten years more than 250 individuals have been evaluated due to profound hearing loss and 170 of them were found to be suitable candidates for cochlear implantation. One hundred and fifty (150) have already been operated and most of them are children with congenital hearing loss. No major or permanent complications were recorded in any of our 150 patients. Activation and fitting/mapping of the cochlear implant is initiated three weeks post-operatively. Regular follow-up and mapping of the implant are held, more frequently in children, along with specialized speech therapy. Each new mapping is evaluated according to the record of the patient with regard to the acoustic perception of sounds and speech and the discrimination of individual elements of phonation based on a protocol that we have created for the needs of Greek language. Speech discrimination (AHEPA Hospital protocol), before the Implantation, at the activation of the cochlear implant and till 4 years of the follow-up showed that in our patients, we obtained better and faster results in post-speech acquisition adults with recent or chronic deafness and in children with congenital deafness operated before the 5th year of age, who underwent special preoperative speech therapy programme, fact which is in agreement with current literature. Patient satisfaction evaluated by "Sanders" psychometrics tests, was achieved in accordance to pre

  7. Results Chains: a Tool for Conservation Action Design, Management, and Evaluation

    Directory of Open Access Journals (Sweden)

    Richard Margoluis

    2013-09-01

    Full Text Available Every day, the challenges to achieving conservation grow. Threats to species, habitats, and ecosystems multiply and intensify. The conservation community has invested decades of resources and hard work to reduce or eliminate these threats. However, it struggles to demonstrate that its efforts are having an impact. In recent years, conservation project managers, teams, and organizations have found themselves under increasing pressure to demonstrate measurable impacts that can be attributed to their actions. To do so, they need to answer three important questions: (1 Are we achieving our desired impact?; (2 Have we selected the best interventions to achieve our desired impact?; and (3 Are we executing our interventions in the best possible manner? We describe results chains, an important tool for helping teams clearly specify their theory of change behind the actions they are implementing. Results chains help teams make their assumptions behind an action explicit and positions the team to develop relevant objectives and indicators to monitor and evaluate whether their actions are having the intended impact. We describe this tool and how it is designed to tackle the three main questions above. We also discuss the purposes for which results chains have been used and the implications of their use. By using results chains, the conservation community can learn, adapt, and improve at a faster pace and, consequently, better address the ongoing threats to species, habitats, and ecosystems.

  8. 1:1 FASTA update: Using the power of E-values in FASTA to detect potential allergen cross-reactivity

    Directory of Open Access Journals (Sweden)

    Ping Song

    2015-01-01

    Full Text Available In the context of regulatory assessment of transgenic proteins for potential allergenicity, a previous investigation demonstrated that a 1:1 FASTA comparison using an E-value of 1.0E-09 as a criterion is superior to the conventional FASTA search (using the whole sequence as a query for >35% identity over 80 amino acids, but with improved specificity. A further study, using groups of known cross-reactive peanut allergens, indicates the sensitivity of this approach is superior to the conventional FASTA search and equivalent to 80-mer sliding window FASTA search recommended by WHO/FAO. Specifically, the 1:1 FASTA approach eliminated the technical issues resulting from lack of identification of short query sequences with high identity to known allergens, or high identity over short amino acid stretches, and different E-value settings when searching for >35% identity over 80aa. Based on the performance of this simple application of existing bioinformatics tools, and its ease of implementation and interpretation in the context of a regulatory assessment, we advocate that adoption of this 1:1 FASTA approach as a supplement to the FAO/WHO/ CODEX criterion (>35% identity over 80aa formulated 13 years ago. Adoption of this approach eliminates many biologically irrelevant homology hits generated by the FAO/WHO/CODEX criterion and improves the safety assessment of GM crops.

  9. Updated African biomass burning emission inventories in the framework of the AMMA-IDAF program, with an evaluation of combustion aerosols

    Directory of Open Access Journals (Sweden)

    C. Liousse

    2010-10-01

    Full Text Available African biomass burning emission inventories for gaseous and particulate species have been constructed at a resolution of 1 km by 1km with daily coverage for the 2000–2007 period. These inventories are higher than the GFED2 inventories, which are currently widely in use. Evaluation specifically focusing on combustion aerosol has been carried out with the ORISAM-TM4 global chemistry transport model which includes a detailed aerosol module. This paper compares modeled results with measurements of surface BC concentrations and scattering coefficients from the AMMA Enhanced Observations period, aerosol optical depths and single scattering albedo from AERONET sunphotometers, LIDAR vertical distributions of extinction coefficients as well as satellite data. Aerosol seasonal and interannual evolutions over the 2004–2007 period observed at regional scale and more specifically at the Djougou (Benin and Banizoumbou (Niger AMMA/IDAF sites are well reproduced by our global model, indicating that our biomass burning emission inventory appears reasonable.

  10. Augmentation mastopexy after bariatric surgery: evaluation of patient satisfaction and surgical results.

    Science.gov (United States)

    Junior, Wilson Cintra; Modolin, Miguel Luiz Antonio; Rocha, Rodrigo Itocazo; Gemperli, Rolf

    2016-01-01

    to evaluate patient satisfaction and surgical results obtained after mastopexy with breast implant inclusion. we conducted a prospective study of 20 consecutive female patients with a mean age of 39.9 years, submitted to augmentation mastopexy. We applied semi-directed psychological interviews pre and postoperatively. The answers to the evaluations were tabulated, categorized, and allowed patient satisfaction analysis. We evaluated surgical results through photographic analysis of three independent plastic surgeons, in the pre and postoperative periods, when scores were attributed to the following items: breasts shape, breasts volume, breasts symmetry, nipple-areolar complex position, and scar quality and extent. nineteen patients (95%) referred satisfaction with the surgical results attained (pimplantes mamários. estudo prospectivo com 20 pacientes consecutivas do sexo feminino, com média etária de 39,9 anos, que foram submetidas à mastopexia de aumento. Foram aplicadas entrevistas psicológicas semidirigidas nos períodos pré e pós-operatórios e cujas respostas foram tabuladas, divididas em categorias, e possibilitaram a avaliação da satisfação das pacientes. Foi realizada avaliação dos resultados cirúrgicos através da análise fotográfica por três cirurgiões plásticos independentes, nos períodos pré e pós-operatórios, que atribuíram notas aos seguintes itens: forma da mama, volume da mama, simetria entre as mamas, posicionamento do complexo aréolo-papilar e qualidade e extensão das cicatrizes. dezenove pacientes (95%) referiram satisfação com o resultado cirúrgico obtido (p<0,001). A média das somatórias das notas atribuídas pelos três cirurgiões, referentes a cada paciente, variou entre 4,7 e 10, sendo a média geral de 7,28. Os resultados foram considerados bons ou ótimos para 65% da amostra e pobres para 8,4%. houve satisfação de 95% das pacientes com os resultados obtidos pela mastopexia de aumento. A análise fotogr

  11. Results of Formal Evaluation of a Data and Modeling Driven Hydrology Learning Module

    Science.gov (United States)

    Ruddell, B. L.; Sanchez, C. A.; Schiesser, R.; Merwade, V.

    2014-12-01

    New hydrologists should not only develop a well-defined knowledgebase of basic hydrological concepts, but also synthesize this factual learning with more authentic 'real-world' knowledge gained from the interpretation and analysis of data from hydrological models (Merwade and Ruddell, 2012, Wagener et al., 2007). However, hydrological instruction is often implemented using a traditional teacher-centered approach (e.g., lectures) (Wagener, 2007). The emergence of rich and dynamic computer simulation techniques which allow students the opportunity for more authentic application of knowledge (Merwade & Ruddell, 2012). This study evaluates the efficacy of using such data-driven simulations to increase the understanding of the field of hydrology in the lower-division undergraduate geoscience classroom. In this study, 88 students at a local community college who were enrolled in an Introductory Earth Science class were evaluated on their learning performance in a unit on applying the Rational Method to estimate hydrographs and flooding for urban areas. Students were either presented with a data and visualization rich computer module (n=52), or with paper and pencil calculation activities (n=36). All conceptual material presented in lecture was consistent across these two conditions. Students were evaluated for not only changes in their knowledge and application of the concepts within the unit (e.g., effects of urbanization and impervious cover, discharge rates), but also for their broad "T-shaped" profile of professional knowledge and skills. While results showed significant (plearning areas for both groups, there is a significantly larger benefit for the data module group when it came to (1) understanding the effects of urbanization and impervious cover on flooding, (2) applying consistent vocabulary appropriately within context, and (3) explaining the roles and responsibilities of hydrologists and flood managers.

  12. Early Childhood Mental Health Consultation: Results of a Statewide Random-Controlled Evaluation.

    Science.gov (United States)

    Gilliam, Walter S; Maupin, Angela N; Reyes, Chin R

    2016-09-01

    Despite recent federal recommendations calling for increased funding for early childhood mental health consultation (ECMHC) as a means to decrease preschool expulsions, no randomized-controlled evaluations of this form of intervention have been reported in the scientific literature. This study is the first attempt to isolate the effects of ECMHC for enhancing classroom quality, decreasing teacher-rated behavior problems, and decreasing the likelihood of expulsion in targeted children in early childhood classrooms. The sample consisted of 176 target children (3-4 years old) and 88 preschool classrooms and teachers randomly assigned to receive ECMHC through Connecticut's statewide Early Childhood Consultation Partnership (ECCP) or waitlist control treatment. Before randomization, teachers selected 2 target children in each classroom whose behaviors most prompted the request for ECCP. Evaluation measurements were collected before and after treatment, and child behavior and social skills and overall quality of the childcare environment were assessed. Hierarchical linear modeling was used to evaluate the effectiveness of ECCP and to account for the nested structure of the study design. Children who received ECCP had significantly lower ratings of hyperactivity, restlessness, externalizing behaviors, problem behaviors, and total problems compared with children in the control group even after controlling for gender and pretest scores. No effects were found on likelihood of expulsion and quality of childcare environment. ECCP resulted in significant decreases across several domains of teacher-rated externalizing and problem behaviors and is a viable and potentially cost-effective means for infusing mental health services into early childhood settings. Clinical and policy implications for ECMHC are discussed. Copyright © 2016 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  13. Investing in updating: how do conclusions change when Cochrane systematic reviews are updated?

    Science.gov (United States)

    French, Simon D; McDonald, Steve; McKenzie, Joanne E; Green, Sally E

    2005-10-14

    Cochrane systematic reviews aim to provide readers with the most up-to-date evidence on the effects of healthcare interventions. The policy of updating Cochrane reviews every two years consumes valuable time and resources and may not be appropriate for all reviews. The objective of this study was to examine the effect of updating Cochrane systematic reviews over a four year period. This descriptive study examined all completed systematic reviews in the Cochrane Database of Systematic Reviews (CDSR) Issue 2, 1998. The latest version of each of these reviews was then identified in CDSR Issue 2, 2002 and changes in the review were described. For reviews that were updated within this time period and had additional studies, we determined whether their conclusion had changed and if there were factors that were predictive of this change. A total of 377 complete reviews were published in CDSR Issue 2, 1998. In Issue 2, 2002, 14 of these reviews were withdrawn and one was split, leaving 362 reviews to examine for the purpose of this study. Of these reviews, 254 (70%) were updated. Of these updated reviews, 23 (9%) had a change in conclusion. Both an increase in precision and a change in statistical significance of the primary outcome were predictive of a change in conclusion of the review. The concerns around a lack of updating for some reviews may not be justified considering the small proportion of updated reviews that resulted in a changed conclusion. A priority-setting approach to the updating of Cochrane systematic reviews may be more appropriate than a time-based approach. Updating all reviews as frequently as every two years may not be necessary, however some reviews may need to be updated more often than every two years.

  14. Learning the 'SMART' way... results from a pilot study evaluating an interprofessional acute care study day.

    Science.gov (United States)

    Lewis, Robin

    2011-01-01

    A significant number of patients requiring critical care are now being managed outside of critical care facilities. There is evidence that staff looking after these patients lack the necessary knowledge and skills to care for them safely, and that effective pre-registration education can play a significant role in addressing these shortfalls in nurses' knowledge and skills. A team from Sheffield Hallam University, in collaboration with the University of Sheffield, developed a pilot one day interprofessional acute illness programme which was called SMART® (Student Management of Acute illness - Recognition and Treatment). To evaluate the pilot programme, 16 student doctors and 72 student nurses were recruited. A pre- and post-course questionnaire based on the Featherstone et al. (2005) evaluation of ALERT was used to ascertain the students' general level of knowledge of the deteriorating patient, their experiences of and confidence in caring for an acutely unwell patient, and their level of comfort with interprofessional working. The results from the pilot study indicate that the students' levels of knowledge, their levels of confidence and their comfort with interprofessional working all rose after undertaking the programme. The pilot study has a number of implications for the future teaching and learning of acute care clinical skills, within a theoretically based curriculum. 2010 Elsevier Ltd. All rights reserved.

  15. Evaluation of quality of experience in interactive 3D visualization: methodology and results

    Science.gov (United States)

    Tourancheau, Sylvain; Sjöström, Mårten; Olsson, Roger; Persson, Anders; Ericson, Thomas

    2012-03-01

    Human factors are of high importance in 3D visualization, but subjective evaluation of 3D displays is not easy because of a high variability among users. This study aimed to evaluate and compare two different 3D visualization systems (a market stereoscopic display, and a state-of-the-art multi-view display) in terms of user performance and quality of experience (QoE), in the context of interactive visualization. An adapted methodology has been designed in order to focus on 3D differences and to reduce the influence of all other factors. Thirty-six subjects took part in an experiment during which they were asked to judge the quality of their experience, according to specific features. Results showed that a scene understanding and precision was significantly better on the multi-view display. Concerning the quality of experience, visual comfort was judged significantly better on the multi-view display and visual fatigue was reported by 52% of the subjects on the stereoscopic display. This study has permitted to identify some factors influencing QoE such as prior experience and stereopsis threshold.

  16. Summary of results from the National Renewable Energy Laboratory`s vehicle evaluation data collection efforts

    Energy Technology Data Exchange (ETDEWEB)

    Whalen, P.; Kelly, K.; Motta, R.; Broderick, J.

    1996-05-01

    The U.S. DOE National Renewable Energy Laboratory conducted a data collection project for light-duty, alternative fuel vehicles (AFVs) for about 4 years. The project has collected data on 10 vehicle models (from the original equipment manufacturers) spanning model years 1991 through 1995. Emissions data have also been collected from a number of vehicles converted to natural gas (CNG) and liquefied petroleum gas (LPG). Most of the vehicles involved in the data collection and evaluation are part of the General Services Administration`s fleet of AFVs. This evaluation effort addressed the performance and reliability, fuel economy, and emissions of light- duty AFVs, with comparisons to similar gasoline vehicles when possible. Driver-reported complaints and unscheduled vehicle repairs were used to assess the performance and reliability of the AFVs compared to the comparable gasoline vehicles. Two sources of fuel economy were available, one from testing of vehicles on a chassis dynamometer, and the other from records of in-service fuel use. This report includes results from emissions testing completed on 169 AFVs and 161 gasoline control vehicles.

  17. Comparing online and telephone survey results in the context of a skin cancer prevention campaign evaluation.

    Science.gov (United States)

    Hollier, L P; Pettigrew, S; Slevin, T; Strickland, M; Minto, C

    2017-03-01

    A large proportion of health promotion campaign evaluation research has historically been conducted via telephone surveys. However, there are concerns about the continued viability of this form of surveying in providing relevant and representative data. Online surveys are an increasingly popular alternative, and as such there is a need to assess the comparability between data collected using the two different methods to determine the implications for longitudinal comparisons. The present study compared these survey modes in the context of health promotion evaluation research. Data were collected via computer-assisted telephone interviewing and an online panel. In total, 688 and 606 respondents aged between 14 and 45 years completed the online and telephone surveys, respectively. Online respondents demonstrated higher awareness of the advertisement, rated the advertisement as more personally relevant and had better behavioural outcomes compared with the telephone respondents. The results indicate significant differences between the telephone and online surveys on most measures used to assess the effectiveness of a health promotion advertising campaign. Health promotion practitioners could consider the combination of both methods to overcome the deterioration in telephone survey response rates and the likely differences in respondent outcomes.

  18. First results of infrared thermography applied to the evaluation of hydraulic conductivity in rock masses

    Science.gov (United States)

    Pappalardo, Giovanna

    2017-10-01

    An innovative methodological approach using infrared thermography (IRT) provides a potential contribution to the indirect assessment of hydraulic conductivity of jointed rock masses. This technique proved a suitable tool to evaluate the degree of fracturing of rock masses along with their discontinuity systems, which expedite water flow within the rock mass itself. First, based on the latest scientific outcomes on the application of IRT to the geomechanics of rock systems, rock mass surveys were carried out at different outcrops (dolostone, limestone and porphyroid) and hydraulic conductivity was empirically assessed through approaches well known in the international literature. Then, IRT campaigns were performed at each surveyed rock mass, with the purpose of evaluating the corresponding Cooling Rate Index, strictly linked to the cooling attitude of the rock. Such index was correlated with the assessed hydraulic conductivity and satisfactory regression equations were achieved. The interesting results show that hydraulic conductivity values are likely to be linked with the cooling behavior of rock masses, which, in turn, is affected by spacing, aperture and persistence of discontinuities.

  19. Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents – an Evidence-Based Evaluation

    Directory of Open Access Journals (Sweden)

    Nicola L Jones

    2005-01-01

    Full Text Available As an update to previously published recommendations for the management of Helicobacter pylori infection, an evidence-based appraisal of 14 topics was undertaken in a consensus conference sponsored by the Canadian Helicobacter Study Group. The goal was to update guidelines based on the best available evidence using an established and uniform methodology to address and formulate recommendations for each topic. The degree of consensus for each recommendation is also presented. The clinical issues addressed and recommendations made were: population-based screening for H pylori in asymptomatic children to prevent gastric cancer is not warranted; testing for H pylori in children should be considered if there is a family history of gastric cancer; the goal of diagnostic interventions should be to determine the cause of presenting gastrointestinal symptoms and not the presence of H pylori infection; recurrent abdominal pain of childhood is not an indication to test for H pylori infection; H pylori testing is not required in patients with newly diagnosed gastroesophageal reflux disease; H pylori testing may be considered before the use of long-term proton pump inhibitor therapy; testing for H pylori infection should be considered in children with refractory iron deficiency anemia when no other cause has been found; when investigation of pediatric patients with persistent or severe upper abdominal symptoms is indicated, upper endoscopy with biopsy is the investigation of choice; the 13C-urea breath test is currently the best noninvasive diagnostic test for H pylori infection in children; there is currently insufficient evidence to recommend stool antigen tests as acceptable diagnostic tools for H pylori infection; serological antibody tests are not recommended as diagnostic tools for H pylori infection in children; first-line therapy for H pylori infection in children is a twice-daily, triple-drug regimen comprised of a proton pump inhibitor plus two

  20. Comparative evaluation results of CMS replacement resist for e-beam reticle fabrication

    CERN Document Server

    Kobayashi, H; Asakawa, K; Yokoya, Y; Wada, T

    1999-01-01

    Looking for a CMS replacement resist is an urgent assignment for e- beam reticle fabrication, which enables us to maintain flexibility of reticle fabrications. The CMS-EX series was discontinued in 1995, and its stored resin will be used up completely soon in this year 1999. We then tried to find a replacement resist, and examined commercially available resists SEL-N1000, SEL-N1100 and ZEN4400. We studied their behavior to post-spin baking temperature, in order to bring out their potential, by investigating isolated clear pattern fidelity in details as it was the most tough one to make by a negative-working resist. This paper describes our comparative evaluation results of commercially available negative-working resists to determine a CMS- EX-S replacement for e-beam reticle fabrication. (4 refs).

  1. Evaluation of an additive efficacy in broiler litter microbial level control in field: preliminary results

    Directory of Open Access Journals (Sweden)

    Matteo Pennacchi

    2010-01-01

    Full Text Available The present study was conducted to evaluate in field the efficacy of an additive (SOP® C POULTRY, as an agent for the control of micro-organisms in broiler litter. The Total aerobic Microbial Count (TMC, Staphylococcus species (spp., Coliforms, and Salmonella spp. in broiler litter samples of both the Houses, 2 (H2 and 3 (H3, were determined, and also at the end of each cycle the mortality rate was recorded. The results showed significant reduction of all the microbial counts: P= 0.0078 (CMT, 0,0021 (Staphylococcus spp. and 0.0541 (Coliforms, and mortality (P= 0.00106 in treated litter samples H2 and the control H3.

  2. Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

    Directory of Open Access Journals (Sweden)

    Fábio Pascotto de Oliveira

    2011-06-01

    Full Text Available There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA. OBJECTIVE: Identify by means of diffusion tensor imaging (DTI and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume. METHOD: Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers. RESULTS: There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients. CONCLUSION: Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas.

  3. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: Third Results Reports

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2012-05-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. NREL has previously published two reports documenting the operation of the fuel cell bus in service. This report provides a summary of the results with a focus on the bus operation from July 2011 through January 2012.

  4. EVALUATION OF FUNCTIONAL RESULTS OF MEDIAL OPENING WEDGE HIGH TIBIAL OSTEOTOMY FOR UNICOMPARTMENTAL OSTEOARTHRITIS VARUS KNEE

    Directory of Open Access Journals (Sweden)

    Shyam Sundar Bakki

    2017-01-01

    Full Text Available BACKGROUND Osteoarthritis commonly affects the medial compartment of knee giving rise to varus deformity in majority of cases. Significant varus deformity further aggravates the pathology due to medialisation of the weight bearing line osteotomy of the proximal tibia realigns this weight bearing axis, thereby relieving pressure on the damaged medial compartment. OWHTO is a promising option in this scenario because it is associated with high accuracy in correcting the deformity and less number of complications when compared to lateral closing wedge HTO or UKA. In this study, we evaluate the functional outcome of HTO in patients with unicompartmental osteoarthritis. MATERIALS AND METHODS This is a prospective study of patients who attended the orthopaedic outpatient clinic in Government Hospital, Kakinada, between August 2013 to August 2015. The patients were evaluated by clinical examination and weight bearing radiographs. The patients who were found to have unicompartmental osteoarthritis with knee pain not relieved by conservative management and who satisfy the inclusion criteria were selected. RESULTS Excellent results can be achieved by appropriate selection criteria and planning with long limb weight bearing radiographs. There is an excellent relief of pain, which can be achieved within first few months postoperatively, which is assessed by VAS score. The KSS- knee score is excellent in 35%, good in 40%, fair in 20% and poor in 5%. The KSS- function score is excellent in 30%, good in 45%, fair in 20% and poor in 5%. There is significant improvement in the range of movement of the knee joint postoperatively. CONCLUSION In this study, we conclude that medial OWHTO is the preferred modality for unicompartmental OA in those aged <60 years and in developing nations like India where squatting is an important function, it has major role as it can restore near normal knee function without disturbing anatomy.

  5. Evaluation of the results of oral food challenges conducted in specialized and general hospitals

    Science.gov (United States)

    Sakai, Kazunori; Sasaki, Kemal; Furuta, Tomoko; Sugiura, Shiro; Watanabe, Yukari; Kobayashi, Takae; Kawabe, Takashi; Morishita, Masashi; Nakanishi, Kumiko

    2017-01-01

    Background Oral food challenge (OFC) tests are conducted in both specialized institutions and general hospitals. We aimed to compare the severity of the conditions of the patients between these 2 types of institutions in order to consider the role of such institutions in society. Objective We evaluated the results of OFC tests for hen's egg, cow's milk, and wheat that were conducted in a specialized institution (Aichi Children's Health and Medical Center [ACHMC], n = 835) and in 4 general hospitals (n = 327) in Aichi prefecture, Japan. Methods The symptoms provoked were scored using the total score (TS) of the Anaphylaxis Scoring Aichi scoring system in combination with the total ingested protein dose (Pro) before the appearance of allergic symptoms. Results The total ingested dose of the challenge-positive patients in ACHMC was significantly less than that in the general hospitals (p < 0.01). The median TS of the provoked symptoms in ACHMC and the general hospitals did not differ to a statistically significant extent in the hen's egg or cow's milk challenges; however, the median TS in ACHMC was significantly lower than that in the general hospitals for the wheat challenge (p = 0.02). The median TS/Pro values in ACHMC were almost identical to the upper 25% of the TS/Pro values in the general hospitals, suggesting that the specialized institution usually managed more severe patients. Conclusion The specialized institution performed OFC tests at a lower threshold dose, but provoked similar TSs to the general hospitals. This evaluation may help in optimizing the distribution of patients to general hospitals and specialized institutions. PMID:29094022

  6. Exploring risk communication - results of a research project focussed on effectiveness evaluation

    Science.gov (United States)

    Charrière, Marie; Bogaard, Thom; Junier, Sandra; Mostert, Erik

    2016-04-01

    The need for effective science communication and outreach efforts is widely acknowledged in the academic community. In the field of Disaster Risk Reduction, the importance of communication is clearly stressed, e.g. in the newly adopted Sendai Framework for Disaster Risk Reduction 2015-2030 (under the 1st priority of action: understanding disaster risk). Consequently, we see increasing risk communication activities. However, the effectiveness of these activities is rarely evaluated. To address this gap, several research activities were conducted in the context of the Marie Curie Initial Training Network "Changes", the results of which we will present and discuss. First, results of a literature review show, among others, that research on effectiveness is mainly focussed on the assessment of users' needs and their ability to understand the content, rather than on the final impact of the risk communication efforts. Moreover, lab-environment research is more often undertaken than assessment of real communication efforts. Second, a comparison between perceptions of risk managers and the general public of risk communication in a French Alps Valley highlighted a gap between the two groups in terms of amount of information needed (who wants more), the important topics to address (what) and the media to use (how). Third, interviews with developers of smartphone applications for disseminating avalanche risk information showed a variety of current practices and the absence of measurements of real their effectiveness. However, our analysis allowed identifying good practices that can be an inspiration for risk communication related to other hazards. Fourth, an exhibition has been set up following a collaborative approached based on stakeholder engagement. Using a pre/post-test design, the immediate impact of the exhibition, which aimed at increasing the risk awareness of the population (Ubaye Valley, France), was measured. The data obtained suggests that visiting the exhibition

  7. SOME STATISTICAL RESULTS REGARDING THE EVALUATION OF THE QUALITY OF THE MASTER EDUCATION

    Directory of Open Access Journals (Sweden)

    POPA IRIMIE

    2011-12-01

    Full Text Available The article emphasizes aspects regarding the evaluation of the higher education's quality. In certain countries, the questionnaires regarding quality of the activity of HEIs (Higher Education Institutions are administrated by specialized institutions led by the Ministry of Education or the university associations. The evaluation principles derive from well-known economic and social theories, evolving even evaluation models (see the SERVQUAL model. As a result of the Bologna Treaty (1999, the European Union has the objective to become an international reference concerning the higher education quality and to be more attractive than in the present for students, professors and researchers from other regions of the world. So as to fulfill these objectives ENQA (European Association for Quality Assurance in Higher Education recommends HEIs to include in their development plans regarding quality aspects five principles described in the article. The practical study refers to the results of a questionnaire applied to the master business students from a Romanian university. In order to assess the level of satisfaction of students in relation to the master programme they are involved in, a questionnaire was applied on a sample of 200 such persons. The responses were then analyzed using multidimensional data analysis methods. Out of these, the present research is based on multiple response analysis. In the questionnaire, students were asked to return their level of satisfaction for different aspects related to the educational process they are involved in. The questions were constructed as five-level Likert items. In this way was insured a connection between answers given at each of the questions assessing the quality of the programme. Only 0.2% of the answers given relate to aspects about which the students were not satisfied at all. These answers represent 3.2% of the number of respondents. 30% of the students were slightly satisfied, returning 57 choices

  8. The Cohort Report: Four Year Results for the Class of 1987 and an Update on the Class of 1986. OEA Evaluation Report.

    Science.gov (United States)

    Gampert, Richard; Shore, Rima

    The cohort method was used to compute graduation and dropout rates for 81,847 New York City public high school students who entered grade 9 in 1983-84 and were expected to graduate in June, 1987. Separate studies were conducted for the following: (1) self-contained special education classes whose students were born in 1969 (Special Education Class…

  9. EVALUATION OF RESULTS IN FRACTURES OF BOTH BONES FOREARM TREATED WITH DYNAMIC COMPRESSION PLATING

    Directory of Open Access Journals (Sweden)

    Sindhuja G

    2017-06-01

    Full Text Available BACKGROUND The anatomical alignment of the bones, the length, the radial bow, and axis should be restored for a good functional outcome. Conservative treatment has resulted in malunion, non-union, synostosis and ultimately poor functional outcome. Internal fixation helps in perfect reduction of fracture fragments in anatomical position by rigid fixation and early mobilisation, the normal functions of the hand can be re-achieved at the earliest. This study has been taken up to evaluate the results of open reduction and internal fixation of the fractures of BBFA with DCP in adults and its advantages and complications. In this study, the rate and time taken for union, the complication, the functional results in terms of forearm rotation and wrist and elbow movements are evaluated. MATERIALS AND METHODS This study includes treatment of 20 cases of fracture of both bones of forearm by open reduction and internal fixation with 3.5 mm DCP from August 2013 to August 2015 at Department of Orthopaedics at Konaseema Institute of Medical Sciences, Amalapuram. Follow-up was done up to September 2015. This is a prospective time bound study. Sample size - 20 patients. Inclusion Criteria- 1. Simple fractures. 2. Open fractures-Gustilo and Anderson type I and type II. 3. Age criteria = 15 to 70 years, both males and females. Exclusion Criteria- 1. Age criteria 0 to 14 years & > 70 years. 2. Radiologically proven segmental fractures and isolated forearm bone fractures. 3. Pathological fracture. 4. Gustilo and Anderson type III. 5. Patient not willing for surgery. 6. Patient unfit for surgery. RESULTS The present study consists of 20 cases of fracture both bones of the forearm. All the cases were openly reduced and internally fixed with 3.5 mm DCP. The study period was from August 2013 to September 2015. The age of these patients ranged from 15-70 years with fracture being most common in 3 rd decade and an average age of 31 years. CONCLUSION Use of separate

  10. Update of European bioethics

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl

    2015-01-01

    , the principles of autonomy, dignity, integrity and vulnerability are proposed as the most important ethical principles for respect for the human person in biomedical and biotechnological development. This approach to bioethics and biolaw is presented here in a short updated version that integrates the earlier......This paper presents an update of the research on European bioethics undertaken by the author together with Professor Peter Kemp since the 1990s, on Basic ethical principles in European bioethics and biolaw. In this European approach to basic ethical principles in bioethics and biolaw...... research in a presentation of the present understanding of the basic ethical principles in bioethics and biolaw....

  11. Women's Health Endocrine Update.

    Science.gov (United States)

    Kapoor, Ekta; Faubion, Stephanie; Hines, Stephanie; Stuenkel, Cynthia A

    2017-11-07

    The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. We have chosen to highlight research on subclinical hypothyroidism during pregnancy and adverse pregnancy outcomes, including cognitive outcomes in offspring; the progression of metabolic syndrome severity during the menopausal transition; and the association of diabetes and metformin use with cancer risk and mortality.

  12. Alternative energies. Updates on progress

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, German (ed.) [CIRCE - Centre of Research for Energy Resources and Consumption, Zaragoza (Spain)

    2013-07-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  13. Evaluation of treatment results of patients with Dupuytren's contracture--our clinical experience.

    Science.gov (United States)

    Kobus, Kazimierz; Wójcicki, Piotr; Dydymski, Tomasz; Wegrzyn, Marek; Hamlawi, Fahed

    2007-01-01

    Dupuytren's contracture is a common condition leading to impairment of the function of the hand which affects from 2 to 12 % of the population, mainly males, and presents as progressive contracture of fingers caused by shortening of the palmar aponeurosis. The objective of the work was to present our own approach to managing Dupuytren's disease and evaluate treatment results in patients with hypertrophy of the palmar aponeurosis. Material and method 288 patients with Dupuytren's disease were treated at the Plastic Surgery Hospital in Polanica Zdroj over a period of 25 years (1977-2002). The present paper is a retrospective analysis of treatment results in 253 patients for whom complete medical documentation was available. All patients were operated in local anaesthesia in ischemia. A Bunnell flap skin incision was followed by a fasciectomy of the hypertrophied segment of the palmar aponeurosis. The skin wound was closed using V-Y plasty. Postoperative management involved hand elevation and early rehabilitation. Results Restoration of the full range of motion and total extension in the MP joint and the interphalangeal joints were achieved in 70% and 68% of patients, respectively. Of 145 patients who were professionally active, 132 were able to return to work. Finger amputation was necessary in 2 patients, one patient suffered from arthrodesis and two other developed skin necrosis which was removed with the wound closed by skin grafts. A follow-up examination 6 months after the operation revealed a recurrence in 8 patients and deterioration of hand dexterity with finger stiffness in 4. Conclusions A low complication rate and good treatment results are arguments in favour of the approach adopted at our hospital, i.e. surgery in local anaesthesia in ischemia with compressive bandaging, using a Bunnell flap skin incision followed by radical fasciectomy and V-Y plasty.

  14. United States Department of Education Update

    Science.gov (United States)

    Linton, John

    2008-01-01

    In this article, the author provides updates on the various programs of the United States Department of Education. Among others, the Office of Correctional Education is sponsoring training sessions dealing with the utilization of post release outcome data to evaluate institutionally based educational services. Also, a few weeks after the upcoming…

  15. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis.

    Science.gov (United States)

    Ramsden, Christopher E; Zamora, Daisy; Leelarthaepin, Boonseng; Majchrzak-Hong, Sharon F; Faurot, Keturah R; Suchindran, Chirayath M; Ringel, Amit; Davis, John M; Hibbeln, Joseph R

    2013-02-04

    To evaluate the effectiveness of replacing dietary saturated fat with omega 6 linoleic acid, for the secondary prevention of coronary heart disease and death. Evaluation of recovered data from the Sydney Diet Heart Study, a single blinded, parallel group, randomized controlled trial conducted in 1966-73; and an updated meta-analysis including these previously missing data. Ambulatory, coronary care clinic in Sydney, Australia. 458 men aged 30-59 years with a recent coronary event. Replacement of dietary saturated fats (from animal fats, common margarines, and shortenings) with omega 6 linoleic acid (from safflower oil and safflower oil polyunsaturated margarine). Controls received no specific dietary instruction or study foods. All non-dietary aspects were designed to be equivalent in both groups. All cause mortality (primary outcome), cardiovascular mortality, and mortality from coronary heart disease (secondary outcomes). We used an intention to treat, survival analysis approach to compare mortality outcomes by group. The intervention group (n=221) had higher rates of death than controls (n=237) (all cause 17.6% v 11.8%, hazard ratio 1.62 (95% confidence interval 1.00 to 2.64), P=0.05; cardiovascular disease 17.2% v 11.0%, 1.70 (1.03 to 2.80), P=0.04; coronary heart disease 16.3% v 10.1%, 1.74 (1.04 to 2.92), P=0.04). Inclusion of these recovered data in an updated meta-analysis of linoleic acid intervention trials showed non-significant trends toward increased risks of death from coronary heart disease (hazard ratio 1.33 (0.99 to 1.79); P=0.06) and cardiovascular disease (1.27 (0.98 to 1.65); P=0.07). Advice to substitute polyunsaturated fats for saturated fats is a key component of worldwide dietary guidelines for coronary heart disease risk reduction. However, clinical benefits of the most abundant polyunsaturated fatty acid, omega 6 linoleic acid, have not been established. In this cohort, substituting dietary linoleic acid in place of saturated fats

  16. [Evaluation of alveolar ridge reconstruction and esthetic result following immediate implant].

    Science.gov (United States)

    Wang, Ying; Lin, Ye; Chen, Bo; Zhang, Yu; Di, Ping

    2016-02-18

    To evaluate the bone alteration subject to remodeling and analyze the esthetic result following immediate implant placement of incisors. In this study, 20 patients (13 women, 7 men) were involved, who needed implants for incisors of maxilla. The patients received 23 immediate implants totally. On the day of surgery and 6 months after the implants were placed, Cone beam CT (CBCT) was taken. The thickness of the alveolar ridge and the vertical change of marginal bone levels onthe mesial and distal aspects of theimplants were measured using the computer software (PlanmecaRomexis Viewer 3.6.0.R). The evaluation of esthetic result by labial convexity score (LCS) and papilla index score (PIS) were analyzed pre-operation and one year after the final crown was delivered. The statistics with paired-t test for the measurement data and Willcoxon test for rating data were done by SPSS 20.0. The survival rate in the two-year follow-up was 100%. The measuring point 1 (MP1), MP2, MP3 and MP4 (0, 2, 4, 6 mm apical to the implant platform, respectively) got significant alterations after 6 months of the follow-up. These differences were statistically significant (PAnkylos System and Replace System, respectively, and the difference was not statistical significant . The esthetic results were quite acceptable. Before treatment, 18 incisors rated 3 for LCS, and 2 incisors rated 4 for LCS;after final restoration, only 5 incisors rated 3 for LCS, and 14 incisors rated 2 for LCS. Before treatment, 15 incisors rated 3 for PIS; after final restoration, 13 incisors rated 3 for PIS. There was no statistically significant difference for the PIS pre-operation and 1 year after final restoration, while there was statistically significant negative change for LCS. Even following the proper surgical technique, the alveolar ridge wall still can't be maintained after immediate implant placed in fresh socket of incisors. The inter-dental papilla could be well maintained, while due to the remodeling of

  17. Evaluation of postoperative results from videoarthroscopic treatment for recurrent shoulder dislocation using metal anchors

    Directory of Open Access Journals (Sweden)

    Éder Menegassi Martel

    2016-02-01

    Full Text Available ABSTRACT OBJECTIVE: To clinically and radiologically evaluate the results from videoarthroscopic treatment using metal anchors in patients with recurrent shoulder dislocation and its complications. METHODS: This was a retrospective study on 47 patients (47 shoulders operated by the shoulder group of the orthopedic hospital between February 2010 and February 2012. A questionnaire, interview and physical and radiographic examinations were used, with the classification of Samilson and Pietro. The mean postoperative follow-up was 33 months (range 12-47 months. The statistical analysis consisted of using Fisher's exact test through the IBM SPSS 22 statistical software. The significance level used was 5%. RESULTS: Recurrence was observed in nine cases. The patients were, on average, 26.5 years old at the first episode, and 19.1% were aged 20 years or under. Among these, 55.6% presented recurrence. In relation to age at the time of the surgical procedure, the average age was 27 years, and 12.8% were aged 20 years or under. Nineteen patients presented prominent anchors and, of these, 21% manifested arthrosis. CONCLUSION: There was a statistically identified correlation between the recurrence rate and age less than or equal to 20 years at the times of first dislocation and the surgical procedure. Further studies should be conducted in order to compare the use of absorbable anchors, which despite higher cost, may provide lower risk of developing glenohumeral arthrosis in some cases.

  18. Evaluation of percutaneous radiologic placement of peritoneal dialysis catheters: technical aspects, results, and complications

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Pyo; Oh, Joo Hyeong; Yoon, Yub; Lee, Tae Won; Ihm, Chun Gyoo [Kyunghee University Hospital, seoul (Korea, Republic of)

    2001-01-01

    To evaluate the technical aspects, results and complications of the percutaneous radiologic placement of peritoneal dialysis catheters. Between December 1999 and April 2001, 26 peritoneal dialysis catheters were placed percutaneously in 26 consecutive patients by interventional radiologists. The patient group consisted of 16 men and ten women with a mean age of 55 (range, 30-77) years. The results and complications arising were reviewed, and the expected patency of the catheters was determined by means of Kaplan-Meier survival analysis. The technical success rate for catheter placement was 100% (26/26 patients). Severe local bleeding occurred in one patient due to by inferior epigastric artery puncture, and was treated by compression and electronic cautery. The duration of catheter implantation ranged from 1 to 510 days and the patency rate was 416{+-}45 days. Catheter malfunction occurred in four patients. In two, this was restored by manipulation in the intervention room, and in one, through the use of urokinase. In three patients, peritonitis occurred. Catheters were removed from four patients due to malfunction (n=2), peritonitis (n=1), and death (n=1). Percutaneous radiologic placement of a peritoneal dialysis catheter is a relatively simple procedure that reduces the complication rate and improves catheter patency.

  19. Reconstruction of the medial patellofemoral ligament: Evaluation of the clinical results of autografts versus allografts.

    Science.gov (United States)

    Calvo Rodríguez, R; Figueroa Poblete, D; Anastasiadis Le Roy, Z; Etchegaray Bascur, F; Vaisman Burucker, A; Calvo Mena, R

    2015-01-01

    The purpose of the study was to evaluate the functional results after medial patellofemoral ligament (MPFL) reconstruction in patients using auto- and allograft. A retrospective study was conducted on 28 patients with recurrent patellar dislocation, with 13 patients (13 knees) undergoing MPFL reconstruction with hamstring autograft, and 15 patients (16 knees) with reconstruction surgery with allograft. The total group included 13 males and 15 females, with an age range of 15 to 38 years. The graft-related morbidity was studied and a clinical assessment was performed using the pre- and postoperative Kujala score. Associated complications were reported for each group. All the patients had more than 12 months of follow up. No recurrent dislocations or graft related complications were reported in either group. The post-operative Kujala subjective knee score was 89.2 in the autograft group, and 92.6 in the allograft group (p >.05). One patient in the allograft group received a revision surgery due to poor positioning of anchors. Another patient in the allograft group had non-displaced patella fracture related to the bone tunnels and another patient had flexion deficit and needed mobilization under anesthesia. There were no significant differences between both groups, and the results were comparable. Copyright © 2014 SECOT. Published by Elsevier Espana. All rights reserved.

  20. Introducing Evidence-Based Principles to Guide Collaborative Approaches to Evaluation: Results of an Empirical Process

    Science.gov (United States)

    Shulha, Lyn M.; Whitmore, Elizabeth; Cousins, J. Bradley; Gilbert, Nathalie; al Hudib, Hind

    2016-01-01

    This article introduces a set of evidence-based principles to guide evaluation practice in contexts where evaluation knowledge is collaboratively produced by evaluators and stakeholders. The data from this study evolved in four phases: two pilot phases exploring the desirability of developing a set of principles; an online questionnaire survey…

  1. Comparison of results from quality control of physical parameters and results from clinical evaluation of mammographic images for the mammography screening facilities in Poland.

    Science.gov (United States)

    Fabiszewska, E; Grabska, I; Jankowska, K; Wesolowska, E; Bulski, W

    2011-09-01

    The material for this study comprised control protocols from 248 mammography screening facilities, prepared by physicists employed at 16 Regional Coordinating Centres and the results from the clinical evaluation of mammographic images in 248 facilities in Poland. All mammograms were evaluated independently by three experts selected from a list approved by the national consultant of radiology and diagnostic imaging. The requirements for proper breast positioning, selection of appropriate parameters for exposure and absence of artefacts were fulfilled only in 38 % of inspected mammography facilities. The requirements of the clinical audit were met only in 15 % of the mammography facilities. The requirements for the physical parameters of mammographic equipment were met only in 28 % of them. The requirements of the quality control (QC) tests and clinical audit were not fulfilled only in 19 % of the mammography facilities. Results from the QC of physical parameters are comparable with results from clinical evaluation of mammographic images in 57 % of the mammography facilities in Poland.

  2. Evaluation and refinement of a handheld health information technology tool to support the timely update of bedside visual cues to prevent falls in hospitals.

    Science.gov (United States)

    Teh, Ruth C-A; Visvanathan, Renuka; Ranasinghe, Damith; Wilson, Anne

    2017-11-27

    To evaluate clinicians' perspectives, before and after clinical implementation (i.e. trial) of a handheld health information technology (HIT) tool, incorporating an iPad device and automatically generated visual cues for bedside display, for falls risk assessment and prevention in hospital. This pilot study utilized mixed-methods research with focus group discussions and Likert-scale surveys to elicit clinicians' attitudes. The study was conducted across three phases within two medical wards of the Queen Elizabeth Hospital. Phase 1 (pretrial) involved focus group discussion (five staff) and surveys (48 staff) to elicit preliminary perspectives on tool use, benefits and barriers to use and recommendations for improvement. Phase 2 (tool trial) involved HIT tool implementation on two hospital wards over consecutive 12-week periods. Phase 3 (post-trial) involved focus group discussion (five staff) and surveys (29 staff) following tool implementation, with similar themes as in Phase 1. Qualitative data were evaluated using content analysis, and quantitative data using descriptive statistics and logistic regression analysis, with subgroup analyses on user status (P ≤ 0.05). Four findings emerged on clinicians' experience, positive perceptions, negative perceptions and recommendations for improvement of the tool. Pretrial, clinicians were familiar with using visual cues in hospital falls prevention. They identified potential benefits of the HIT tool in obtaining timely, useful falls risk assessment to improve patient care. During the trial, the wards differed in methods of tool implementation, resulting in lower uptake by clinicians on the subacute ward. Post-trial, clinicians remained supportive for incorporating the tool into clinical practice; however, there were issues with usability and lack of time for tool use. Staff who had not used the tool had less appreciation for it improving their understanding of patients' falls risk factors (odds ratio 0.12), or

  3. Evaluation of Methacholine Challenge Test Results in Chronic Cough Patients Referring to Clinic of Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    Derakhshan Deilami Gholamreza

    2009-10-01

    Full Text Available Chronic cough is a common problem in patients visiting physicians and its prevalence in different populations range from 3 to 40%. Postnasal drip, asthma and gastroesophageal reflux are the known cause of chronic cough. Although diagnosis of asthma is usually made by clinical signs and spirometeric results, methacholine challenge test is a good diagnostic test in patients who show normal physical examination and spirometeric results. In this study, the results of methacholine challenge test in chronic cough patients are investigated. This is a cross sectional study performed on patients suffering from chronic cough (over 8 weeks, who went to Pulmonary Disease Clinic of Imam Khomeini Hospital in 2006. Postnasal drip, gastroesophageal reflux was evaluated and ruled out in all patients. Then they were tested by methacholine inhalation using low to high doses of methacholine. The results of test was defined as 20% fall in FEV1 and its relationship with age, sex, history of allergic disease, family history of asthma and smoking status was investigated. 81 patients (36 female and 45 male entered this study who had mean age of 32.5 ± 13.06 years. 81.5% of patients had never smoked or closed contact with smokers, 6.2% were passive smokers, 8.6% were smokers and 3.7% had quit smoking. 37% had suffered from chronic cough less than 6 months, 11% for 6-11 months and 52% for more than 12 months. In 26% of patients, family history of asthma was present and 34.5% had a history of one type of allergy. In 29.5% the results of methacholine challenge test was positive, among them 45.8% showed an intense response and 54.2% a moderate response. The test results and its intensity had no statistically significant relationship with age, sex, smoking status, the duration of cough and family history of asthma, but the relationship between methacholine challenge test and the history of allergic disease was significant. Methacholine challenge test can be used as a

  4. [Evaluation of dysphagia. Results after one year of incorporating videofluoroscopy into its study introduction].

    Science.gov (United States)

    García Romero, Ruth; Ros Arnal, Ignacio; Romea Montañés, María José; López Calahorra, José Antonio; Gutiérrez Alonso, Cristina; Izquierdo Hernández, Beatriz; Martín de Vicente, Carlos

    2017-11-09

    Dysphagia is very common in children with neurological disabilities. These patients usually suffer from respiratory and nutritional problems. The videofluoroscopic swallowing study (VFSS) is the most recommended test to evaluate dysphagia, as it shows the real situation during swallowing. To analyse the results obtained in our centre after one year of the implementation of VFSS, the clinical improvement after confirmation, and the prescription of an individualised treatment for the patients affected. VFSS performed in the previous were collected. The following variables were analysed: age, pathology, degree of neurological damage, oral and pharyngeal and/or oesophageal dysphagia and its severity, aspirations, prescribed treatment, and nutritional and respiratory improvement after diagnosis. A statistical analysis was performed using SPSS v21. A total of 61 VFSS were performed. Dysphagia was detected in more than 70%, being moderate-severe in 58%. Aspirations and/or penetrations were recorded in 59%, of which 50% were silent. Adapted diet was prescribed to 56%, and gastrostomy was performed on 13 (21%) patients. A statistical association was found between neurological disease and severity of dysphagia. The degree of motor impairment is related to the presence of aspirations. After VFSS evaluation and treatment adjustment, nutritional improvement was found in Z-score of weight (+0.3SD) and BMI (+0.4SD). There was respiratory improvement in 71% of patients with dysphagia being controlled in the Chest Diseases Department. After implementation of VFSS, a high percentage of patients were diagnosed and benefited from a correct diagnosis and treatment. VFSS is a fundamental diagnostic test that should be included in paediatric centres as a diagnostic method for children with suspected dysphagia. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  5. Community dialogues for child health: results from a qualitative process evaluation in three countries.

    Science.gov (United States)

    Martin, Sandrine; Leitão, Jordana; Muhangi, Denis; Nuwa, Anthony; Magul, Dieterio; Counihan, Helen

    2017-06-05

    Across the developing world, countries are increasingly adopting the integrated community case management of childhood illnesses (iCCM) strategy in efforts to reduce child mortality. This intervention's effectiveness is dependent on community adoption and changes in care-seeking practices. We assessed the implementation process of a theory-driven community dialogue (CD) intervention specifically designed to strengthen the support and uptake of the newly introduced iCCM services and related behaviours in three African countries. A qualitative process evaluation methodology was chosen and used secondary project data and primary data collected in two districts of each of the three countries, in purposefully sampled communities. The final data set included 67 focus group discussions and 57 key informant interviews, totalling 642 respondents, including caregivers, CD facilitators community leaders, and trainers. Thematic analysis of the data followed the 'Framework Approach' utilising both a deduction and induction process. Results show that CDs contribute to triggering community uptake of and support for iCCM services through filling health information gaps and building cooperation within communities. We found it to be an effective approach for addressing social norms around child care practices. This approach was embraced by communities for its flexibility and value in planning individual and collective change. Regular CDs can contribute to the formation of new habits, particularly in relation to seeking timely care in case of child sickness. This study also confirms the value of process evaluation to unwrap the mechanisms of community mobilisation approaches in context and provides key insights for improving the CD approach.

  6. The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results

    Directory of Open Access Journals (Sweden)

    F. Trotta

    2011-09-01

    Full Text Available Objective: The aim of this study was to investigate the performance of functional neuro-imaging for describe neurological involvement in Lupus Erithematosus Systemicus. Methods. 20 SLE patients were included into this study (18 females / 2 males. Median age was 40.5 years (range 16 –66 ys, 9 patients with a clear neurological involvement, 7 with aspecific neurological symptoms and 4 were asymptomatics, according to 1999 ACR Classification. All patients were underwent to conventional resonance imaging (RMFLAIR, RM perfusion ( RM-PWI, RM diffusion (RM-DWI and cerebral SPECT. The RM techniques was performed using a 1 Tesla “Signa-Horizon” Tomograph by General Eletric: The data analysis was performed from two indipendent neuroradiologist and than trough coordinated evalutation after coregistration of acquired volumes. Results: In 11/20 patients (55% lesions were demonstrated in RM-FLAIR evaluation, more frequent in cases with focal symptoms than in diffuse. RM-PWI was positive in 50% of cases. SPECT analysis was altered in 85 % of patients. In all patients RM-DWI evaluation was negative. 5 of 29 lesional areas (3 patients showed by SPECT analysis were positive in RM-PWI. None of them was positive in RM-FLAIR study. After coordinated evaluation of RM-FLAIR, SPECT and RM-PWI, 7 findings were considered false positive. 6 Of patients with negative RM-FLAIR were positive in SPECT and 3 in RM-PWI. Only 1 patient was positive in SPECT and RM-PWI. Conclusions: According to the literature, the RM-FLAIR is a very sensitive procedure to describe the lesional charge, especially in patients with focal symptoms. All lesions was considered as stable outcomes due to negativity of RM-DWI analysis. The SPECT is a sensitive technique to individuate cerebral areas of altered perfusion. The coregistration seems to be an helpful method to improve the explanation of uncertain cases. e the sections are prepared for the microscopic analysis of the various

  7. SOFT TISSUE RECONSTRUCTION OF THE LOWER EXTREMITY: EVALUATION OF SURGICAL RESULTS IN 15 PATIENTS

    Directory of Open Access Journals (Sweden)

    M.J FATEMI

    2003-03-01

    Full Text Available Introduction: There are general guidelines for reconstruction of complex wounds of the Lower extremity. The goal in treatment of these wounds is to preserve a limb that will be more functional than an amputation. Material & Methods: In this study, we evaluate our results in 15 patients with extensive wounds in lower extremities (April - 1998 to march - 2001. Results: The average age of the patients was 31.20 with an age range between 9 to 61 years. Majority of the patients were victims of motor vehicle accident, except two, which developed wounds due to war injury. Distal third of leg was the most common site of trauma and 7 patients had bone fractures, mostly Gustillo III-B. Wound coverage was the most common indication for surgery and free tissue transplantation performed for majority of the patients. Transfer of latissimus dorsi muscle or myocutaneous flap was the most common procedure. One free flap and one fasciocutaneous flap necrosed due to infection and poor technique respectively. Discussion: Our results revealed that the options for reconstruction of significant soft tissue wounds of the upper and lower thigh are included skin graft, local flap and rarely free tissue transfer. The gastrocnemius muscle or myocutaneous flap serve well for supra-patellar, knee and proximal tibial wounds. The soleus muscle flape is probably the most useful flap in middle tibia However, frequently; wounds of this part are best satisfied by micro vascular tissue transplantation. Soft tissue reconstruction in distal tibia and foot is viewed by many as the most challenging of all lower extremity areas. The vast majority of these wounds are best satisfied by micro vascular tissue transfer. Meanwhile, in cases with a modest skin defect, there is the opportunity to utilize either proximally or distally based fasciocutaneous flaps.

  8. Evaluation the Difference between Results of MRI and Electrodiagnostic Methods in Inferior Lumbosacral Discopathies

    Directory of Open Access Journals (Sweden)

    Mohammad Shimia

    2014-01-01

    Full Text Available Introduction: To achieve an appropriate treatment for low back pain we should know the exact reason of the pain. Beside physical examination, imaging modalities like CT scan and MRI are the other diagnostic methods for LBP. Furthermore, electrodiagnostic studies help to diagnose the reason behind radiculopathy. Actually when the reason of radiculopathy is unclear, these methods help to localize the exact nerve root causing the pain and rule out the similar reasons of radiculopathy. The aim of this study was to compare MRI and EMG in diagnosing the reason of lumbosacral radiculopathies. Methods: In this cross sectional descriptive-analytical study, the number of patients who came to neurosurgery clinics with LBP and lumbar discopathy and been evaluated by MRI and EMG were studied. Later, for every patient a questionnaire was completed based on the results achieved from MRI and EMG and the obtained results were compared. Results: 100 patients were participated in this study, 60% female and 40% male. The average age of patients was 39/75 years. The most frequent chief complaint of patients was LBP with a prevalence of 43%. MRI findings showed 64% involvement of L4/L5 level in these patients. On the other hand, EMG findings also showed L4/L5 level involvement in 64% of patients confirming the hypothesis of our study that MRI and EMG findings are compatible with each other in determining the level and intensity of disc involvement. Conclusion: For determining the level of injury in lumbosacral radiculopathies, both MRI and EMG are equally useful. Additionally, in borderline cases we can use EMG to confirm MRI findings to determine the intensity and level of injury. Keywords: Lumbosacral radiculopathy; Magnetic Resonance Imaging; Electromyography

  9. Research and optimization of page updated forecast on Nutch

    Directory of Open Access Journals (Sweden)

    HU Wei

    2016-08-01

    Full Text Available Web page updated prediction method of Nutch is an adjacent method and its relevant update parameters need to be set artificially,not adaptively adjustable,and unable to cope with the differences of massive web page updates.To address this problem,this paper puts forward dynamic selection strategy to improve the method of Nutch web page updated prediction.When the historical updated web page data are insufficient,the strategy uses DBSCAN clustering algorithm based on MapReduce to reduce the number of the pages of the crawler system crawling,the update cycle of the sample web pages is used as update cycle of other pages which are in the same category.When the historical updated web page data are enough,the data are used to model with the Poisson Process,which can more accurately predict each web page update cycle.Finally the improving strategy is tested in the Hadoop distributed platform.The experimental results show that the performance of optimized web page updated prediction method is better.

  10. Update: Biological Nitrogen Fixation.

    Science.gov (United States)

    Wiseman, Alan; And Others

    1985-01-01

    Updates knowledge on nitrogen fixation, indicating that investigation of free-living nitrogen-fixing organisms is proving useful in understanding bacterial partners and is expected to lead to development of more effective symbioses. Specific areas considered include biochemistry/genetics, synthesis control, proteins and enzymes, symbiotic systems,…

  11. Drug interactions: 1998 update.

    Science.gov (United States)

    1998-12-01

    (1) The 1998 edition of the Drug Interactions section of the French data sheet compendium (Dictionnaire Vidal) includes welcome updates. (2) Increasingly numerous interactions involve tramadol, clarithromycin, oral anticoagulants, antiepileptics, theophylline and various psychotropic agents. (3) An entire section is now devoted to the numerous potassium-raising drugs.

  12. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Wednesday 14 June between 8.00 p.m. and midnight. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  13. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Monday 3 July between 8.00 p.m. and 3.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  14. Update of telephone exchange

    CERN Document Server

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on Monday 3 July between 8.00 p.m. and 3.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation.We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  15. Update of telephone exchange

    CERN Multimedia

    2006-01-01

    As part of the upgrade of telephone services, the CERN switching centre will be updated on between Monday 23 October 8.00 p.m. and Tuesday 24 October 2.00 a.m. Telephone services may be disrupted and possibly even interrupted during this operation. We apologise in advance for any inconvenience this may cause. CERN TELECOM Service

  16. Dynamic update with probabilities

    NARCIS (Netherlands)

    Van Benthem, Johan; Gerbrandy, Jelle; Kooi, Barteld

    2009-01-01

    Current dynamic-epistemic logics model different types of information change in multi-agent scenarios. We generalize these logics to a probabilistic setting, obtaining a calculus for multi-agent update with three natural slots: prior probability on states, occurrence probabilities in the relevant

  17. [Cardiology update in 2016].

    Science.gov (United States)

    Gabus, Vincent; Tran, Van Nam; Regamey, Julien; Pascale, Patrizio; Monney, Pierre; Hullin, Roger; Vogt, Pierre

    2017-01-11

    In 2016 the European Society of Cardiology (ESC) published new guidelines. These documents update the knowledge in various fields such as atrial fibrillation, heart failure, cardiovascular prevention and dyslipidemia. Of course it is impossible to summarize these guidelines in detail. Nevertheless, we decided to highlight the major modifications, and to emphasize some key points that are especially useful for the primary care physician.

  18. Office Operative Hysteroscopy: An Update.

    Science.gov (United States)

    Salazar, Christina Alicia; Isaacson, Keith

    2017-08-10

    Hysteroscopy is considered the gold standard for the evaluation of intracavitary pathology in both premenopausal and postmenopausal patients associated with abnormal uterine bleeding, as well as for the evaluation of infertile patients with suspected cavity abnormalities. Office-based operative hysteroscopy allows patients to resume activities immediately and successfully integrates clinical practice into a "see and treat" modality, avoiding the added risks of anesthesia and the inconvenience of the operating room. For 2017, the Centers for Medicare and Medicaid Services has provided a substantial increase in reimbursement for a select number of office-based hysteroscopic procedures. This review provides an update on the indications, equipment, and procedures for office hysteroscopy, as well as the management of complications that may arise within an office-based practice. Copyright © 2017. Published by Elsevier Inc.

  19. ANALYSIS OF PROFESSORS’ EVALUATION AT LA SALLE UNIVERSITY MÉXICO FROM 2010 TO 2016: WHAT THE RESULTS INDICATE?

    Directory of Open Access Journals (Sweden)

    Flegl, Martin

    2017-09-01

    Full Text Available La Salle University México (La Salle uses an internal system of professors’ evaluation, which main purpose is to evaluate professors’ performance and secure high quality of teaching at all of its faculties. Since its inception in 2010, La Salle has obtained 517,635 individual evaluations of 45,346 courses. However, no additional analysis of the obtained results has ever been done. This article provides introductory analysis of the accumulated results at faculty level. The main objective is to analyze whether there are differences between faculties regarding the evaluation. Although the results are highly skewed towards the maximal evaluation at all faculties, there are statistically significant differences. The next important task is to investigate what factors influence the evaluation. Moreover, as this is the introductory analysis, the article concludes with possible future steps that should be consider regarding eventual structural changes in the evaluation system.

  20. Heuristic reusable dynamic programming: efficient updates of local sequence alignment.

    Science.gov (United States)

    Hong, Changjin; Tewfik, Ahmed H

    2009-01-01

    Recomputation of the previously evaluated similarity results between biological sequences becomes inevitable when researchers realize errors in their sequenced data or when the researchers have to compare nearly similar sequences, e.g., in a family of proteins. We present an efficient scheme for updating local sequence alignments with an affine gap model. In principle, using the previous matching result between two amino acid sequences, we perform a forward-backward alignment to generate heuristic searching bands which are bounded by a set of suboptimal paths. Given a correctly updated sequence, we initially predict a new score of the alignment path for each contour to select the best candidates among them. Then, we run the Smith-Waterman algorithm in this confined space. Furthermore, our heuristic alignment for an updated sequence shows that it can be further accelerated by using reusable dynamic programming (rDP), our prior work. In this study, we successfully validate "relative node tolerance bound" (RNTB) in the pruned searching space. Furthermore, we improve the computational performance by quantifying the successful RNTB tolerance probability and switch to rDP on perturbation-resilient columns only. In our searching space derived by a threshold value of 90 percent of the optimal alignment score, we find that 98.3 percent of contours contain correctly updated paths. We also find that our method consumes only 25.36 percent of the runtime cost of sparse dynamic programming (sDP) method, and to only 2.55 percent of that of a normal dynamic programming with the Smith-Waterman algorithm.

  1. Evaluation of photopatch test allergens for Indian patients of photodermatitis: Preliminary results

    Directory of Open Access Journals (Sweden)

    Nidhi Jindal

    2011-01-01

    Full Text Available Background: There is a strong need to develop a photopatch test tray suitable for Indian patients of photodermatitis as European/Scandinavian photopatch test trays may not be wholly relevant for them. Aim: We carried out this study using photoallergens relevant in the Indian context to determine their relevance in patients of photodermatitis. Methods: Thirty patients (M:F, 23:7 between 19 and 76 years of age of photodermatitis and 10 controls were patch- and photopatch tested with 20 common photoallergens. In addition, the patients were also (photo patch tested with articles of daily use as and when these were suspected to be the cause. Results: Forty-three positive reactions to one or more antigens were seen in 22 (74% patients. Fourteen positive photopatch tests to seven allergens were observed in 10 (33% patients, and nine (30% of them had a definite relevance. The most common contact allergen was fragrance mix (FM (30%, followed by p-phenylenediamine (20% and Parthenium hysterophorous (17%. The definite relevance of the patch- and photopatch tests could be correlated in 47% of these patients. Conclusions: FM is the most common contact and photocontact allergen among the various photopatch test antigens. Although differences in technique and evaluation make direct comparison between different centers difficult, still photopatch testing remains an integral part and gold standard for the work-up of the photosensitive patients.

  2. Developing Teenage Youth's Science Identity Through an Astronomy Apprenticeship: Summative Evaluation Results

    Science.gov (United States)

    Barros-Smith, R.; Porro, I.; Norland, E.

    2012-08-01

    We report on the results from the summative evaluation of the Youth Astronomy Apprenticeship (YAA) covering three years of implementation of the program. YAA is a year-long, out-of-school time initiative that connects urban teenage youth with astronomy as an effective way to promote scientific literacy and overall positive youth development. The program employs the strategies of a traditional apprenticeship model, common in crafts and trade guilds as well as in higher education. During the apprenticeship, youth develop knowledge and skills to create informal science education projects; through these projects they demonstrate their understanding of astronomy and use their communication skills to connect to general audiences. For some youth, participation extends across multiple years and their responsibilities for program implementation become multifaceted. Through exposing youth to astronomy investigations and providing opportunities to connect with audiences outside their program and communities, YAA expands scientific literacy to include assuming a science identity. We subscribe to the concept of science identity that describes personal ownership and integration of science into an individual's sense of self through processes of comprehension and personal meaning making. In the YAA context, science identity extends to and includes assuming an actual science advocacy role. Our methods for measuring the development of a science identity included assessments of a youth's perceived and actual understanding of science (cognitive construct), leadership in science (behavior construct), and commitment to science (affective construct).

  3. The safety of UK video telemetry units: results of a national service evaluation.

    Science.gov (United States)

    Kandler, Rosalind; Lai, Ming; Ponnusamy, Athi; Bland, Jeremy; Pang, Catherine

    2013-12-01

    To assess patient safety during seizures occurring on UK video telemetry units and identify factors in unit infrastructure which may improve safety with the intention of producing national guidelines. A prospective multicentre national service evaluation of the occurrence of adverse events and level of nurse attendance during seizures occurring on video telemetry units was performed. Data from 272 seizures from 27 video telemetry units across the UK were analysed. Adverse events occurred in 12% of seizures: 7% were physical events such as falls or respiratory compromise and 5% were unnoticed seizures. Nursing staff did not attend the patients in 44% of seizures and attendance was delayed beyond 30s in a further 29%. Only 27% of seizures were attended by a Healthcare Professional within half a minute. The most important factor shown to improve timely attendance of patients during seizures was the presence of a nurse dedicated to the telemetry bed(s). The site of the telemetry bed (bay or cubicle) and method of observation (direct or indirect) was less important. An optimal nurse-to-patient ratio was difficult to identify but the study suggests that a ratio of at least 1 nurse to 4 patients is appropriate. The results provide an evidence base for the production of national standards and guidelines for surveillance of patients during video telemetry to improve patient safety. Copyright © 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  4. "5 A Day" achievement badge for urban boy scouts: formative evaluation results.

    Science.gov (United States)

    Cullen, K W; Baranowski, T; Baranowski, J; Warnecke, C; de Moor, C; Nwachokor, A; Hajek, R A; Jones, L A

    1998-01-01

    Certain cancers are more common among African Americans (AA). Fruit and vegetables (F&V) reduce cancer risk, but Americans, and African Americans in particular, do not meet the "5 A Day" goal. Scouting organizations, particularly urban Boy Scout groups that target inner-city youth, provide promising channels for nutritional behavioral change programs. Focus groups were conducted with urban Boy Scouts and their parents to identify factors influencing F&V consumption and evaluate potential intervention activities. Twenty-four-hour dietary recalls were collected from 85 area Boy Scouts. A national data set was used to obtain values for F&V consumption by African American and European American (boys age 0-16). Vegetable preferences were low and a negative peer influence for vegetables was reported. The group has limited food-preparation skills, but both parents and scouts reported that F&V were available in their homes. Use of goal setting and use of problem-solving techniques were limited. The local scouts' mean F&V intake was 3.2 servings per day. Ethnic differences in F&V consumption were identified in the national data. Based on these results and previous interventions in schools, an overall structure for the intervention was developed to include eight weekly troop sessions and two camping sessions, parent newsletters, seven weekly home badge assignments, and ten comic books.

  5. A multi-site evaluation of innovative approaches to increase tuberculosis case notification: summary results.

    Directory of Open Access Journals (Sweden)

    Jacob Creswell

    Full Text Available BACKGROUND: Globally, TB notifications have stagnated since 2007, and sputum smear positive notifications have been declining despite policies to improve case detection. We evaluate results of 28 interventions focused on improving TB case detection. METHODS: We measured additional sputum smear positive cases treated, defined as the intervention area's increase in case notification during the project compared to the previous year. Projects were encouraged to select control areas and collect historical notification data. We used time series negative binomial regression for over-dispersed cross-sectional data accounting for fixed and random effects to test the individual projects' effects on TB notification while controlling for trend and control populations. RESULTS: Twenty-eight projects, 19 with control populations, completed at least four quarters of case finding activities, covering a population of 89.2 million. Among all projects sputum smear positive (SS+ TB notifications increased 24.9% and annualized notification rates increased from 69.1 to 86.2/100,000 (p = 0.0209 during interventions. Among the 19 projects with control populations, SS+TB case notifications increased 36.9% increase while in the control populations a 3.6% decrease was observed. Fourteen (74% of the 19 projects' SS+TB notification rates in intervention areas increased from the baseline to intervention period when controlling for historical trends and notifications in control areas. CONCLUSIONS: Interventions were associated with large increases in TB notifications across many settings, using an array of interventions. Many people with TB are not reached using current approaches. Different methods and interventions tailored to local realities are urgently needed.

  6. Results of a prospective evaluation of three methods of management of pediatric cataracts.

    Science.gov (United States)

    Basti, S; Ravishankar, U; Gupta, S

    1996-05-01

    Although a variety of approaches to manage cataracts in children have been studied, no consensus exists on the optimum approach. The authors, therefore, conducted a prospective, nonrandomized, consecutive study to evaluate three most commonly adopted methods of management of pediatric cataracts. Lensectomy anterior vitrectomy (LAV), extracapsular cataract extraction with intraocular lens implantation (ECCE + IOL) and ECCE, primary posterior capsulotomy, anterior vitrectomy with IOL (ECCE + PPC + AV + IOL) were the surgical procedures performed. Aphakia in the LAV group was corrected with spectacles or contact lenses. Intraoperative and postoperative results were analyzed. Discrete variables among the three groups were compared using chi square test. One hundred ninety-two eyes were included in the study. There was no statistically significant difference in the intraoperative complications in the three groups. During a mean follow-up period of 11.3 months, postoperative obscuration of the visual axis was seen in 43.7% of eyes in the ECCE + IOL group and in 3.65% of eyes in the ECCE + PC + AV + IOL (p contact lenses were prescribed developed corneal infiltrates. Severe postoperative anterior uveitis occurred in 15.9% and 13.8% of eyes in the ECCE + PPC + AV + IOL and ECCE + IOL groups, respectively. None of the eyes that underwent LAV developed this complication (P maintenance of a clear visual axis, provided optimum refractive correction, and was not associated with increased risk of short-term complications. Continued follow-up of these eyes is necessary to conclude on the long term results of this technique.

  7. Evaluation of anterior chest wall implanted port: technical aspects, results, and complications

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Young Hwan; Oh, Joo Hyeong; Yoon, Yup; Kim, Si Young [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    2000-07-01

    To evaluate the technical aspects, results and complications of patients with implanted anterior chest wall port. Between April 1997 and June 1999, a total of 63 implanted ports were placed at the anterior chest wall of 63 consecutive patients by interventional radiologists. The indications were chemotherapy in 61 patients and total parenteral nutrition in two. The peripheral portion of the subclavian vein was punctured under fluoroscopic guidance via ipsilateral peripheral vein during venography. A central venous catheter was placed in the superior vena cava, and using the subcutaneous tunneling method, a connected infusion port was implanted at the anterior chest wall. Results and complications were reviewed, and by means of Kaplan-Meier survival analysis, the expected patency of the port was determined. The technical success rate for implanted port at the anterior chest wall was 100% (63/63 patients). In two patients, hematoma and oozing were treated by compression. The duration of port implantation ranged from 12 to 855 (mean, 187) days, and the port patency rate was 305.7{+-}47.6 days. In seven patients (completed chemotherapy (n=3D3), central venous thrombosis (n=3D3) catheter-related infection (n=3D1)), the port was removed. Catheter obstruction occurred in two patients, and in one, the use of urokinase led to successful recanalization. Sixteen patients died of an underlying malignancy, but no catheter-related death was noted. Implantation of an anterior chest wall port is a safe and useful procedure, with long patency, for patients requiring chemotherapy and long-term venous access. (author)

  8. EVALUATION OF THE RESULTS OF THE USE OF VEPTR IN PATIENTS WITH SCOLIOSIS

    Directory of Open Access Journals (Sweden)

    JOÃO PAULO SILVA ARAÚJO

    Full Text Available ABSTRACT Objective: Evaluation of the results of the use of VEPTR (Vertical Expandable Prosthetic Titanium Rib - Synthes Spine Co.(r, West Chester, Pennsylvania, USA as an option in spinal instrumentation without fusion in younger children with scoliosis, considering the complications inherent to spinal fusion in this age group. Methods: Sixteen (16 patients with scoliosis, regardless of etiology, with a mean age of 5.2 (3-8 years, were followed up by Spine Surgery Group at Hospital Getúlio Vargas, Recite-PE, and were submitted to surgical correction of the deformity using VEPTR, from April/2009 to July/2014. The survey was conducted through medical register review, and photographic and radiographic records, with the measurement of pre- and postoperative curves by the Cobb method. Results: The mean values of Cobb angle in the preoperative period, in the immediate postoperative period and after the last distraction were, respectively, 84.1° (112°-60°, 55.4° (92°-16° and 64.4° (100°-16°, with an average initial correction of 28.7° (34.1% and final correction of 19.7° (23.4%. The mean follow-up was 23.1 (0-61 months with an average distraction of 3.1 (0-8. The complication rate in this study was 62.5%. Conclusion: The VEPTR presented considerable correction rates of scoliosis curves in patients whose age contraindicate the spinal fusion methods. It is necessary to improve the technique and the implant itself in order to reduce complication rates, which can be considered relatively high, in addition to the conduction of more studies with longer follow-up to determine the actual efficacy of the implant and the maintenance of long-term correction.

  9. Does a virtual like cause actual liking?: How following a brand’s Facebook updates enhances brand evaluations and purchase intention

    NARCIS (Netherlands)

    Beukeboom, C.J.; Kerkhof, P.; Vries, de M.

    2015-01-01

    Studies have shown positive associations between liking a Facebook brand page and brand evaluations, but causal evidence is lacking. This online pre- post-measure experiment compared brand evaluations of ‘current followers’ of a target brand’s Facebook page, with ‘new followers’ instructed to ‘like’

  10. [Reliability for detection of developmental problems using the semaphore from the Child Development Evaluation test: Is a yellow result different from a red result?

    Science.gov (United States)

    Rizzoli-Córdoba, Antonio; Ortega-Ríosvelasco, Fernando; Villasís-Keever, Miguel Ángel; Pizarro-Castellanos, Mariel; Buenrostro-Márquez, Guillermo; Aceves-Villagrán, Daniel; O'Shea-Cuevas, Gabriel; Muñoz-Hernández, Onofre

    The Child Development Evaluation (CDE) is a screening tool designed and validated in Mexico for detecting developmental problems. The result is expressed through a semaphore. In the CDE test, both yellow and red results are considered positive, although a different intervention is proposed for each. The aim of this work was to evaluate the reliability of the CDE test to discriminate between children with yellow/red result based on the developmental domain quotient (DDQ) obtained through the Battelle Development Inventory, 2nd edition (in Spanish) (BDI-2). The information was obtained for the study from the validation. Children with a normal (green) result in the CDE were excluded. Two different cut-off points of the DDQ were used (BDI-2): Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  11. Outcomes of antiretroviral therapy in Vietnam: results from a national evaluation.

    Directory of Open Access Journals (Sweden)

    Duc Bui Nguyen

    Full Text Available Vietnam has significantly scaled up its national antiretroviral therapy (ART program since 2005. With the aim of improving Vietnam's national ART program, we conducted an outcome evaluation of the first five years of the program in this concentrated HIV epidemic where the majority of persons enrolled in HIV care and treatment services are people who inject drugs (PWID. The results of this evaluation may have relevance for other national ART programs with significant PWID populations.Retrospective cohort analysis of patients at 30 clinics randomly selected with probability proportional to size among 120 clinics with at least 50 patients on ART.Charts of patients whose ART initiation was at least 6 months prior to the study date were abstracted. Depending on clinic size, either all charts or a random sample of 300 charts were selected. Analyses were limited to treatment-naïve patients. Multiple imputations were used for missing data.Of 7,587 patient charts sampled, 6,875 were those of treatment-naïve patients (74.4% male, 95% confidence interval [CI]: 72.4-76.5, median age 30, interquartile range [IQR]: 26-34, 62.0% reported a history of intravenous drug use, CI: 58.6-65.3. Median baseline CD4 cell count was 78 cells/mm(3 (IQR: 30-162 and 30.4% (CI: 25.8-35.1 of patients were at WHO stage IV. The majority of patients started d4T/3TC/NVP (74.3% or d4T/3TC/EFV (18.6%. Retention rates after 6, 12, 24, and 36 months were 88.4% (CI: 86.8-89.9, 84.0% (CI: 81.8-86.0, 78.8% (CI: 75.7-81.6, and 74.6% (CI: 69.6-79.0. Median CD4 cell count gains after 6, 12, 24, and 36 months were 94 (IQR: 45-153, 142 (IQR: 78-217, 213 (IQR: 120-329, and 254 (IQR: 135-391 cells/mm(3. Patients who were PWID showed significantly poorer retention.The study showed good retention and immunological response to ART among a predominantly PWID group of patients despite advanced HIV infections at baseline.

  12. An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence.

    Science.gov (United States)

    Cai, Yu-Long; Song, Pei-Pei; Tang, Wei; Cheng, Nan-Sheng

    2016-06-01

    The main obstacle to achieving an R0 resection after a major hepatectomy is inability to preserve an adequate future liver remnant (FLR) to avoid postoperative liver failure (PLF). Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting tumors that were previously considered unresectable, and this technique results in a vast increase in the volume of the FLR in a short period of time. However, this technique continues to provoke heated debate because of its high mortality and morbidity.The evolution of ALPPS and its advantages and disadvantages have been systematically reviewed and evaluated in accordance with current evidence. Electronic databases (PubMed and Medline) were searched for potentially relevant articles from January 2007 to January 2016.ALPPS has evolved into various modified forms. Some of these modified techniques have reduced the difficulty of the procedure and enhanced its safety. Current evidence indicates that the advantages of ALPPS are rapid hypertrophy of the FLR, the feasibility of the procedure, and a higher rate of R0 resection in comparison to other techniques. However, ALPPS is associated with worse major complications, more deaths, and early tumor recurrence.Hepatobiliary surgeons should carefully consider whether to perform ALPPS. Some modified forms of ALPPS have reduced the mortality and morbidity of the procedure, but they cannot be recommended over the original procedure currently. Portal vein embolization (PVE) is still the procedure of choice for patients with a tumor-free FLR, and ALPPS could be used as a salvage procedure when PVE fails. More persuasive evidence needs to be assembled to determine whether ALPPS or two-stage hepatectomy (TSH) is better for patients with a tumor involving the FLR. Evidence with regard to long-term oncological outcomes is still limited. More meticulous comparative studies and studies of the 5-year survival rate of ALPPS could ultimately

  13. Piloted Simulator Evaluation Results of New Fault-Tolerant Flight Control Algorithm

    NARCIS (Netherlands)

    Lombaerts, T.J.J.; Smaili, M.H.; Stroosma, O.; Chu, Q.P.; Mulder, J.A.; Joosten, D.A.

    2010-01-01

    A high fidelity aircraft simulation model, reconstructed using the Digital Flight Data Recorder (DFDR) of the 1992 Amsterdam Bijlmermeer aircraft accident (Flight 1862), has been used to evaluate a new Fault-Tolerant Flight Control Algorithm in an online piloted evaluation. This paper focuses on the

  14. D2.3.3 Evaluation results of the LinkedUp VICI competition

    NARCIS (Netherlands)

    Drachsler, Hendrik

    2014-01-01

    This document D2.3.3 is the final report of Task 2.4 – Evaluation of challenge submissions. Task 2.4 is about the actual assessment of the participating projects within the LinkedUp Veni, Vidi and Vici competition on the basis of the LinkedUp Evaluation Framework (D2.2.1). The main objective of

  15. D2.3.2 Evaluation results of the LinkedUp VIDI competition

    NARCIS (Netherlands)

    Drachsler, Hendrik; Stoyanov, Slavi; Herder, Eelco; Marieke, Guy; Maren, Scheffel

    2014-01-01

    This document D2.3.2 is the second report of Task 2.4 - Evaluation of challenge submissions. Task 2.4 is about the actual assessment of the participating projects within the LinkedUp Veni, Vidi and Vici competition on the basis of the LinkedUp Evaluation Framework (D2.2.1). The main objective of

  16. Aligning Evaluation Results and Professional Development: Driving Systemic Human Capital Management Reform

    Science.gov (United States)

    Behrstock-Sherratt, Ellen; Jacques, Catherine

    2012-01-01

    This brief provides district and other educational leaders with research-based information on aligning professional development policies with teacher evaluations to drive more comprehensive human capital management. First, this brief describes an aligned evaluation and professional development system. Next, it discusses existing models and…

  17. KDOQI US Commentary on the 2017 KDIGO Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).

    Science.gov (United States)

    Isakova, Tamara; Nickolas, Thomas L; Denburg, Michelle; Yarlagadda, Sri; Weiner, Daniel E; Gutiérrez, Orlando M; Bansal, Vinod; Rosas, Sylvia E; Nigwekar, Sagar; Yee, Jerry; Kramer, Holly

    2017-12-01

    Chronic kidney disease-mineral and bone disorder (CKD-MBD) encompasses laboratory and bone abnormalities and vascular calcification and has deleterious effects on clinical outcomes. KDOQI (Kidney Disease Outcomes Quality Initiative), an initiative of the National Kidney Foundation, addressed this issue with the publication of a clinical practice guideline for bone metabolism and disease in CKD in 2003, and 2 years later, a new definition and classification scheme for CKD-MBD was developed following a KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference. The initial KDIGO guideline on CKD-MBD was then published in 2009. New evidence was subsequently reviewed at the 2013 KDIGO Controversies Conference, and in 2017, KDIGO issued a clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of CKD-MBD. This commentary presents the views of the KDOQI CKD-MBD work group convened by the National Kidney Foundation. The KDOQI work group agrees with most of the KDIGO guideline update recommendations, particularly the suggestions regarding bone mineral density testing, joint assessments of longitudinal trends in mineral metabolism markers, and dietary phosphate counseling focused on phosphate additives. However, the KDOQI work group has some concerns about the suggestions related to hypocalcemia and hypercalcemia, phosphate-binder choice, and treatment of abnormal parathyroid hormone concentrations. The overall goal of this commentary is to provide a broad discussion for the US nephrology community regarding CKD-MBD and its diagnosis, prevention, and treatment. Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  18. [The use of LapSim virtual reality simulator in the evaluation of laparoscopic surgery skill. Preliminary results].

    Science.gov (United States)

    Tomulescu, V; Popescu, I

    2004-01-01

    The aim of this study is to establish if the results obtained in the evaluation of the candidates for the laparoscopic surgery competence using the LapSim virtual reality simulator are comparable with intraoperative evaluation. For this study has been evaluated in front of the LapSim and in the operating room a number of 12 surgeons who have achieved the criteria for laparoscopic surgery competence evaluation. The results of any one of the candidates have been evaluated, on Lapsim and by the exam committee in the operation room relating to four criteria: (1) utilization of 300 camera; (2) manipulation and coordination of laparoscopic instruments, suturing; (3) grasping and cutting; (4) clip applying. The evaluation has been made relating to the time need for every candidate to perform the asked task, and the subjective evaluation of the examining committee with marks from 1 to 10. The LapSim evaluation, in concordance with intraoperative evaluation managed to establish 2 candidates with deficiency in manipulation and coordination of laparoscopic instruments, and difficulty in the laparoscopic bidimensional field orientation. We consider this experiment only the beginning in the evaluation of the utility of virtual reality simulator in the training and examination of the results in laparoscopic surgery. We consider that large series of subjects with different levels of knowledge in laparoscopic surgery have to be evaluated to conclude if the benefit of laparoscopic surgery virtual reality simulator is the same as in airplane pilots.

  19. [Prospective Evaluation of the Quality of the Results of Thyroid Surgery in an ENT-Department].

    Science.gov (United States)

    Issing, Peter Rolf; Tebben, Hendrik; Wenger, Martin; Köhler, Torsten

    2017-04-01

    Although the thyroid gland is located in the neck it is not a matter of fact that it is a clinical issue for the otorhinolaryngologist in Germany. Probably due to historic reasons general surgeons usually perform operations on the thyroid. As at our department this kind of treatment is an established procedure we prospectively evaluated our thyroid cases in order to present our results.The prospective study started in the year of 2014. So far 231 patients were enrolled with an average age of 53,5 years (16-89). The sex ratio showed a preponderance of the female patients with 187 and 64 males. In 155 cases we didn't insert a Redon-drainage. The mean operation time was 133 min. The preoperative concentration of calcium was 2.44 mg/ml with a postoperative decrease to 2.21 mg/ml. In cases of malignancies revealed in histology a second procedure with complete thyroidectomy and neck dissection took place immediately afterwards.Many symptoms of disorders of the thyroid become manifest in a genuine region of our speciality. Therefore we cannot detect any convincing reason why head and neck surgeons should not perform thyroidectomies. Skills like the specific clinical examination, the preoperative diagnostic work flow including sonography, the precise surgical management of soft tissue and neural structures and the postoperative care are typical features of our discipline. However, besides the surgeon's expertise a close collaboration with the colleagues of nuclear medicine and the general practitioner respectively the endocrinologist is mandatory in order to achieve a high quality of treatment. © Georg Thieme Verlag KG Stuttgart · New York.

  20. Radiation Hardening by Software Techniques on FPGAs: Flight Experiment Evaluation and Results

    Science.gov (United States)

    Schmidt, Andrew G.; Flatley, Thomas

    2017-01-01

    We present our work on implementing Radiation Hardening by Software (RHBSW) techniques on the Xilinx Virtex5 FPGAs PowerPC 440 processors on the SpaceCube 2.0 platform. The techniques have been matured and tested through simulation modeling, fault emulation, laser fault injection and now in a flight experiment, as part of the Space Test Program- Houston 4-ISS SpaceCube Experiment 2.0 (STP-H4-ISE 2.0). This work leverages concepts such as heartbeat monitoring, control flow assertions, and checkpointing, commonly used in the High Performance Computing industry, and adapts them for use in remote sensing embedded systems. These techniques are extremely low overhead (typically radiation hardened processor. The recently concluded STP-H4 flight experiment was an opportunity to upgrade the RHBSW techniques for the Virtex5 FPGA and demonstrate them on-board the ISS to achieve TRL 7. This work details the implementation of the RHBSW techniques, that were previously developed for the Virtex4-based SpaceCube 1.0 platform, on the Virtex5-based SpaceCube 2.0 flight platform. The evaluation spans the development and integration with flight software, remotely uploading the new experiment to the ISS SpaceCube 2.0 platform, and conducting the experiment continuously for 16 days before the platform was decommissioned. The experiment was conducted on two PowerPCs embedded within the Virtex5 FPGA devices and the experiment collected 19,400 checkpoints, processed 253,482 status messages, and incurred 0 faults. These results are highly encouraging and future work is looking into longer duration testing as part of the STP-H5 flight experiment.

  1. A multi-site evaluation of innovative approaches to increase tuberculosis case notification: summary results.

    Science.gov (United States)

    Creswell, Jacob; Sahu, Suvanand; Blok, Lucie; Bakker, Mirjam I; Stevens, Robert; Ditiu, Lucica

    2014-01-01

    Globally, TB notifications have stagnated since 2007, and sputum smear positive notifications have been declining despite policies to improve case detection. We evaluate results of 28 interventions focused on improving TB case detection. We measured additional sputum smear positive cases treated, defined as the intervention area's increase in case notification during the project compared to the previous year. Projects were encouraged to select control areas and collect historical notification data. We used time series negative binomial regression for over-dispersed cross-sectional data accounting for fixed and random effects to test the individual projects' effects on TB notification while controlling for trend and control populations. Twenty-eight projects, 19 with control populations, completed at least four quarters of case finding activities, covering a population of 89.2 million. Among all projects sputum smear positive (SS+) TB notifications increased 24.9% and annualized notification rates increased from 69.1 to 86.2/100,000 (p = 0.0209) during interventions. Among the 19 projects with control populations, SS+TB case notifications increased 36.9% increase while in the control populations a 3.6% decrease was observed. Fourteen (74%) of the 19 projects' SS+TB notification rates in intervention areas increased from the baseline to intervention period when controlling for historical trends and notifications in control areas. Interventions were associated with large increases in TB notifications across many settings, using an array of interventions. Many people with TB are not reached using current approaches. Different methods and interventions tailored to local realities are urgently needed.

  2. Evaluation of Results in Patients with Acute Upper Gis Bleeding: A Goverment Hospital Experience

    Directory of Open Access Journals (Sweden)

    Bilge Bas

    2016-01-01

    Full Text Available Aim: The aim was to assess the characteristics of patients with upper gastrointestinal system (GIS bleeding in our clinic. Material and Method: The patients who admitted to Usak State Hospital Gastroenterology Department with upper gastrointestinal system bleeding were retrospectively evaluated between May 2009 and March 2012. The patients were assessed for age, sex, complaints, history of medication, management, history of bleeding, laboratory findings, endoscopic findings, need for transfusion, hospitalization duration and mortality. Results: 392 patients admitted to our department with upper gastrointestinal system bleeding. 263 (67.1% of the patient were male and 129 (32.9% were female. It was presented only melena in 120 (%30.6 patients, hematemesis in 140 (%35.7 patients and both hematemesis and melena in 132 (%33.7 patients at admission. The mean hemoglobin level was 7.8±1.5 g/dl, and the mean hematocrit level was 27.4±4%. It was established coronary artery disease in 50 (12.8% patients, diabetes mellitus in 20 (5.1% patients, cerebrovascular disease in 8 (2% patients and peripheral arterial disease in 4 (1% patients. We presented 194 (49.5% bulbus ulcer, 117 (29.8% erosive gastritis, 35 (8.9% gastric ulcer in patients at upper gastrointestinal system endoscopy. We established Helicobacter pylori infection in 264 (67.3 % patients. Discussion: Duodenal ulcer and eritematous gastritis are the most common causes of upper GIS bleedings. In addition, Helicobacter pylori infection is keep in mind as a important bleeding cause in that patients. It is useful to give stomach acid suppressor therapy to the patients who have coronary heart disease, cerebrovascular disease and diabetes mellitus, especially if they have gastric complaints.

  3. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey

    Directory of Open Access Journals (Sweden)

    Sivanandy P

    2016-07-01

    Full Text Available Palanisamy Sivanandy,1 Mari Kannan Maharajan,1 Kingston Rajiah,1 Tan Tyng Wei,2 Tan Wee Loon,2 Lim Chong Yee2 1Department of Pharmacy Practice, School of Pharmacy, 2School of Pharmacy, International Medical University, Wilayah Persekutuan Kuala Lumpur, Malaysia Background: Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use.Objective: To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia.Methods: A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted.Results: The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of “staff training and skills” were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup.Conclusion: The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety. Keywords

  4. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey

    Science.gov (United States)

    Sivanandy, Palanisamy; Maharajan, Mari Kannan; Rajiah, Kingston; Wei, Tan Tyng; Loon, Tan Wee; Yee, Lim Chong

    2016-01-01

    Background Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use. Objective To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia. Methods A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted. Results The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of “staff training and skills” were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup. Conclusion The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety. PMID:27524887

  5. Evaluation of bronchoscopic lung volume reduction coil treatment results in patients with severe emphysema.

    Science.gov (United States)

    Gulsen, Askin; Sever, Fidan; Girgin, Pelin; Tamci, Necdet Batuhan; Yilmaz, Hatice

    2017-09-01

    Bronchoscopic lung volume reduction coil (BLVR-C) implantation is an alternative therapeutic approach that can be applied together with medical treatment for patients with severe emphysema. BLVR-C is both easier and safer in terms of complications than volume reduction surgery. This study aimed to evaluate medium-term outcomes following BLVR-C treatment. Forty patients who underwent BLVR-C between September 2013 and March 2014 were reviewed retrospectively. We compared changes between the baseline and 6-month post-procedural results with respect to pulmonary function tests, a 6-min walk test (6MWT), chronic obstructive pulmonary disease (COPD) assessment test (CAT), St. George's Respiratory Questionnaire (SGRQ), and pulmonary artery pressure (PAP) and arterial blood gas analyses. Secondary outcomes included procedure-related and follow-up complications. An average of 9.5 (range: 5-11) coils were placed per lung in an average procedural duration of 20.8 ± 7.0 min (range: 9-45) min. Six months after BLVR-C treatment, significant improvements were observed in patients' pulmonary function tests and quality of life. Changes were observed in the forced exhalation volume in 1 s (+150 mL), residual volume (-14.5%), 6MWT (+48 m), SGRQ (-10.5) and CAT Score (-7.5). Changes in the PAP and partial pressure of carbon dioxide values were not significant, and pneumothorax did not occur. In a 6-month follow-up, 11 cases of COPD exacerbation (41.4%), 7 cases of pneumonia (16.9%) and 1 death (2%) occurred. Treatment in 1 case was postponed because of hypotension and bradycardia during the process. BLVR-C treatment appears to be effective over the medium-term and safe for patients with severe emphysema. © 2015 John Wiley & Sons Ltd.

  6. How healthcare systems evaluate their advance care planning initiatives: Results from a systematic review.

    Science.gov (United States)

    Biondo, Patricia D; Lee, Lydia D; Davison, Sara N; Simon, Jessica E

    2016-09-01

    Advance care planning initiatives are being implemented across healthcare systems around the world, but how best to evaluate their implementation is unknown. To identify gaps and/or redundancies in current evaluative strategies to help healthcare systems develop future evaluative frameworks for ACP. Systematic review. Peer-reviewed and gray literature searches were conducted till February 2015 to answer: "What methods have healthcare systems used to evaluate implementation of advance care planning initiatives?" A PICOS framework was developed to identify articles describing the implementation and evaluation of a health system-level advance care planning initiative. Outcome measures were mapped onto a conceptual quality indicator framework based on the Institute of Medicine and Donabedian models of healthcare quality. A total of 46 studies met inclusion criteria for analysis. Most articles reported on single parts of a healthcare system (e.g. continuing care). The most common outcome measures pertained to document completion, followed by healthcare resource use. Patient-, family-, or healthcare provider-reported outcomes were less commonly measured. Concordance measures (e.g. dying in place of choice) were reported by only 26% of studies. The conceptual quality indicator framework identified gaps and redundancies in measurement and is presented as a potential foundation from which to develop a comprehensive advance care planning evaluation framework. Document completion is frequently used to evaluate advance care planning program implementation; capturing the quality of care appears to be more difficult. This systematic review provides health system administrators with a comprehensive summary of measures used to evaluate advance care planning and may identify gaps in evaluation within their local context. © The Author(s) 2016.

  7. HFE Process Guidance and Standards for potential application to updating NRC guidance

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; J. J. Persensky

    2012-07-01

    The U.S. Nuclear Regulatory Commission (NRC) reviews and evaluates the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of these guidance documents to ensure that they remain state-of-the-art design evaluation tools. Thus, the NRC has initiated a project with BNL to update the NRC guidance to remain current with recent research on human performance, advances in HFE methods and tools, and new technology. INL supported Brookhaven National Lab (BNL) to update the detailed HFE review criteria contained in NUREG-0711 and NUREG-0700 based on (1) feedback obtained from end users, (2) the results of NRC research and development efforts supporting the NRC staff’s HFE safety reviews, and (3) other material the project staff identify as applicable to the update effort. INL submitted comments on development plans and sections of NUREGs 0800, 0711, and 0700. The contractor prepared the report attached here as the deliverable for this work.

  8. The results and methodological concerns about pharmaco-economic evaluation in anesthesia

    Directory of Open Access Journals (Sweden)

    Majstorović Branislava M.

    2014-01-01

    Full Text Available Background Globalization and profitable health (cost/benefit requires pharmacoeconomic evaluation of the costs in relation to effectiveness of the methods of treatment. The objective of this study was to analyze the cumulative costs of anesthesia in all surgical disciplines using the Activity-Based Costing (ABC analysis. Methods This work is a part of Phase IV clinical study. Retrospectively, for 2006, direct costs of anesthesia services were calculated: (1 personnel costs (salaries, (2 drugs and supplies, (3 other costs (analysis and apparatus in the Institute of Anesthesiology and Resuscitation, Clinical Center of Serbia. The research group included all anesthetized patients of both genders and ofall ages. Summary data documented in the anesthesia department and databases of the Clinical Center of Serbia and the Republic Institute of Health Insurance were used. Numerical data were calculated and analyzed by computer programs Microsoft Office Excel 2003 and SPSS for Windows. Results The results of direct costs showed that personnel costs accounted for 40%, medicines and supplies - 31.80% and other costs - 28.20% of the funds. Anesthesia costs accounted for 10% (ABC analysis of direct costs. Methodological dilemmas were related to the inaccuracy of anesthetic and surgical protocols, the classification of anesthetic and surgical services and the imperfection of computer data entry software. Basic hospital activities information should be more specific and precise. Clinical protocols of the anesthetized patients should be connected better with the Admission department, Intensive care units, Day surgical hospital and other departments. Database of the clinical drug pathway, Clinical protocols, Accounting Information Systems, and Hospital Management Information Systems should be precise, specific and managed in a better way. Conclusions The costs of local and general anesthesia procedures are objectively low and numerous, what may be objectified by

  9. Evaluation of a novel noninvasive ICP monitoring device in patients undergoing invasive ICP monitoring: preliminary results.

    Science.gov (United States)

    Ganslandt, Oliver; Mourtzoukos, Stylianos; Stadlbauer, Andreas; Sommer, Björn; Rammensee, Rudolf

    2017-08-08

    OBJECTIVE There is no established method of noninvasive intracranial pressure (NI-ICP) monitoring that can serve as an alternative to the gold standards of invasive monitoring with external ventricular drainage or intraparenchymal monitoring. In this study a new method of NI-ICP monitoring performed using algorithms to determine ICP based on acoustic properties of the brain was applied in patients undergoing invasive ICP (I-ICP) monitoring, and the results were analyzed. METHODS In patients with traumatic brain injury and subarachnoid hemorrhage who were undergoing treatment in a neurocritical intensive care unit, the authors recorded ICP using the gold standard method of invasive external ventricular drainage or intraparenchymal monitoring. In addition, the authors simultaneously measured the ICP noninvasively with a device (the HS-1000) that uses advanced signal analysis algorithms for acoustic signals propagating through the cranium. To assess the accuracy of the NI-ICP method, data obtained using both I-ICP and NI-ICP monitoring methods were analyzed with MATLAB to determine the statistical significance of the differences between the ICP measurements obtained using NI-ICP and I-ICP monitoring. RESULTS Data were collected in 14 patients, yielding 2543 data points of continuous parallel ICP values in recordings obtained from I-ICP and NI-ICP. Each of the 2 methods yielded the same number of data points. For measurements at the ≥ 17-mm Hg cutoff, which was arbitrarily chosen for this preliminary analysis, the sensitivity and specificity for the NI-ICP monitoring were found to be 0.7541 and 0.8887, respectively. Linear regression analysis indicated that there was a strong positive relationship between the measurements. Differential pressure between NI-ICP and I-ICP was within ± 3 mm Hg in 63% of data-paired readings and within ± 5 mm Hg in 85% of data-paired readings. The receiver operating characteristic-area under the curve analysis revealed that the area

  10. Institutional design and utilisation of evaluation results in Uganda’s public universities: Empirical findings from Kyambogo University

    Directory of Open Access Journals (Sweden)

    James Kabuye

    2017-04-01

    Full Text Available Background: The need for evidence-based decision-making scaled up the need for monitoring and evaluation systems in Africa. The education sector has received increasing scrutiny, owing to its centrality in promoting the national agenda of countries. The higher education sub-sector has expanded in its drive to increase accessibility, albeit with numerous challenges and doubts, especially about the quality of education. Numerous evaluations in this sub-sector in Uganda have been carried out, but their results have not been used for effective decision-making. In this regard, the non-utilisation trend of evaluation findings is attributable to the design of the institutions where these evaluations are carried out.Objectives: The study examined the relationship between institutional design (procedural rules, evaluation processes and institutional capacity and utilisation of evaluation results at Kyambogo University.Methodology: This was a cross-sectional survey involving a sample of 118 respondents whose views were obtained through the use of questionnaires and key informant interviews triangulated with documentary analysis.Results: The study found that procedural rules, evaluation processes and evaluation capacity had a positive (0.459, 0.486 and 0.765, respectively and a statistically significant (sig. = 0.000 effect on utilisation of evaluation results. This means that the dimensions of institutional design were important predictors of utilisation of evaluation results by a public sector agency.Conclusion: Strengthening of the evaluation competences and capacity of the university by empowering the Directorate of Planning and Development to coordinate and harmonise all evaluations and be charged with the follow-up of utilisation of the results is an emerging recommendation from this study.

  11. A treatment algorithm for neuropathic pain: an update.

    Science.gov (United States)

    Namaka, Michael; Leong, Christine; Grossberndt, Amy; Klowak, Meghann; Turcotte, Dana; Esfahani, Farid; Gomori, Andrew; Intrater, Howard

    2009-12-01

    The purpose of this review is to provide an update of the neuropathic pain treatment algorithm previously published by Namaka et al. in 2004. This algorithm focuses on the strategic incorporation of the latest pain therapies while providing an update of any recent developments involving medications previously listed in the algorithm. PubMed, MEDLINE, Cochrane, and Toxnet databases were used to conduct all literature searches on neuropathic pain and targeted treatment strategies. Comprehensive search efforts in the identified databases included studies published between 1980 and 2009. The search term "neuropathic pain" was used along with each of the agents outlined in this review: pregabalin, paroxetine CR, duloxetine, tramadol XL, Tramacet, Sativex, and nabilone. A total of 90 studies were reviewed and selected based on level 1, 2, and 3 search strategies. Level 1 search strategies were initially aimed at evidence-based trials of large sample size (N > 100), with a randomized, double-blind, placebo-controlled design conducted by investigators well versed in the specialty area of interest. A level 2 search was conducted for additional trials that had many, but not all, of the desirable traits of evidence-based trials. In addition, a level 3 search strategy was conducted to compare key findings stated in anecdotal reports of very small (N < 15), poorly designed trials with the results of well-designed, evidence-based trials identified in level 1 and/or level 2 searches. Based on a thorough evaluation of the literature, pregabalin, paroxetine CR, and duloxetine have been placed in the updated algorithm as first-line agents, while tramadol XL, Tramacet, Sativex, and nabilone function primarily as adjunctive agents. The updated algorithm provides a baseline framework from which clinicians can justify the medication they prescribe.

  12. Online self-help for suicidal thoughts: 3-month follow-up results and participant evaluation

    Directory of Open Access Journals (Sweden)

    Bregje A.J. van Spijker

    2015-09-01

    Conclusions: Effects of online self-help for suicidal thoughts can be maintained for up to three months. Participant evaluation indicated that online self-help for suicidal thoughts is acceptable, but there is also room for improvement.

  13. Alameda-Contra Costa Transit District (AC Transit) Fuel Cell Transit Buses: Preliminary Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eudy, L.

    2007-03-01

    This report provides an evaluation of three prototype fuel cell-powered transit buses operating at AC Transit in Oakland, California, and six baseline diesel buses similar in design to the fuel cell buses.

  14. Evaluation of the intelligent cruise control system : volume 1 : study results

    Science.gov (United States)

    1999-10-01

    The Intelligent Cruise Control (ICC) system evaluation was based on an ICC Field Operational Test (FOT) performed in Michigan. The FOT involved 108 volunteers recruited to drive ten ICC-equipped Chrysler Concordes. Testing was initiated in July 1996 ...

  15. Side-by-Side Testing of Water Heating Systems: Results from the 2013-2014 Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Colon, Carlos [Florida Solar Energy Center, Cocoa, FL (United States). Bulding America Partnership for Improved Residential Construction

    2017-07-12

    The Florida Solar Energy Center (FSEC) has completed a fourth year-long evaluation on residential hot water heating systems in a laboratory environment (east central Florida, hot-humid climate). This report contains a summary of research activities regarding the evaluation of two residential electric heat pump water heaters (HPWHs), a solar thermal system utilizing a polymer glazed absorber and a high efficiency natural gas system.

  16. Risk Assessment Methodology for Software Supportability (RAMSS): Pilot Evaluation Results and Methodology Refinement.

    Science.gov (United States)

    1986-04-14

    Software Test Manager (STM) and I Deputy for Software Evaluation ( DSE ) provided appropriate calibration assistance. The software support resources...the life cycle to capture this history using the SLCP questions (see reference 1.4.7) as a checklist . (5) The use of the RAMSS tool will aid the...year. The RAMSS system manager would provide expertise to the STM/ DSE for each software OT&E effort, maintain the RAMSS and supporta- bility evaluation

  17. Scintigraphic evaluation of primary congenital hypothyroidism: results of the Greek screening program

    Energy Technology Data Exchange (ETDEWEB)

    Panoutsopoulos, G.; Ilias, I.; Batsakis, C.; Christakopoulou, I. [Dept. of Nuclear Medicine, ' ' Sotiria' ' Hospital, Athens (Greece); Mengreli, C. [Inst. of Child Health, Athens (Greece)

    2001-04-01

    12.5% had DN; in group B, 28.8% of children had AT, 52.0% had ET and 19.2% had DN; in group C, 23.2% of children had AT, 63.2% had ET and 13.6% had DN. Statistically significant differences in group A versus groups B and C were noted for AT and ET. The implementation of newer scintigraphic modalities, and especially the use of {sup 123}I-Na, indicates that the commonest finding in congenital hypothyroidism is ET. Scintigraphy was more concordant with Tg measurements (though at a moderate level) than with US. The latter was even less concordant with Tg values. These results show that the most appropriate approach for the evaluation and classification of congenital hypothyroidism is {sup 123}I-Na scanning. (orig.)

  18. Cohort Profile Update

    DEFF Research Database (Denmark)

    Omland, Lars Haukali; Ahlström, Magnus Glindvad; Obel, Niels

    2014-01-01

    The DHCS is a cohort of all HIV-infected individuals seen in one of the eight Danish HIV centres after 31 December 1994. Here we update the 2009 cohort profile emphasizing the development of the cohort. Every 12-24 months, DHCS is linked with the Danish Civil Registration System (CRS) in order to...... the Danish Data Protection Agency. Potential collaborators can contact the study director, Niels Obel (e-mail: niels.obel@regionh.dk)....

  19. Reflecting on an impact evaluation of the Grade R programme: Method, results and policy responses

    Directory of Open Access Journals (Sweden)

    Marie-Louise Samuels

    2015-08-01

    Full Text Available This paper describes the expansion since 2001 of a public pre-school programme in South Africa known as ‘Grade R’, summarises the findings from an impact evaluation of the introduction of Grade R, discusses the policy recommendations flowing from the evaluation and reflects on the process of implementing the recommendations. The Grade R programme has expanded dramatically, to the point where participation is nearly universal. Although a substantial literature points to large potential benefits from pre-school educational opportunities, the impact evaluation reported on in this article demonstrated that the Grade R programme, as implemented until 2011, had a limited impact on later educational outcomes. Improving the quality of Grade R, especially in schools serving low socio-economic status communities, thus emerges as a key policy imperative. Recommended responses include professionalising Grade R teachers, providing practical in-service support, increasing access to appropriate storybooks, empowering teachers to assess the development of their learners, and improving financial record-keeping of Grade R expenditure by provincial education departments. The impact evaluation was initiated by the Department of Planning, Monitoring and Evaluation (DPME and the Department of Basic Education (DBE, and was conducted by independent researchers. The move towards increased evaluation of key government programmes is important for shifting the focus of programme managers and policymakers towards programme outcomes rather than only programme inputs. Yet the process is not without its challenges: following a clear process to ensure the implementation of the lessons learned from such an evaluation is not necessarily straightforward.

  20. Evaluation of the cytogenetical results of 4707 cases diagnosed with amniocentesis.

    Directory of Open Access Journals (Sweden)

    Ayfer Pazarbasi

    2011-02-01

    Full Text Available PURPOSE: Amniocentesis is a very crucial diagnostic procedure for preventing the birth of genetically defective fetuses in order to decrease the prevalence of genetic diseases in populations. METHODS: The karyotyping of 4707 fetuses was carried out in our department during the years of 2000-2009 from the samples of amniotic fluids, CVS, fetal tissues and urines which were sent from departments of Gynecology and Obstetrics of Balcali Hospital and other regional hospitals. RESULTS: The mean maternel and gestational age of pregnant women evaluated for prenatal diagnosis were 29.1 years of age and 18.8 months respectively. Among 4707 fetuses that were karyotyped; 2284 fetuses were males and 2205 fetuses were females and 218 (4.63% fetuses had various chromosomal abnormalities. Consequently, male to female ratio of fetuses that were examined was 1.03. The advanced maternal age pregnancies followed by positive triplescreening were related to the highest rate of chromosomal abnormalities. The mean age of pregnant women having fetuses with chromosomal abnormalities was found to be 33 years of age which suggest that fetal chromosomal abnormalities were associated with maternal age. Numerical chromosomal abnormalities predominated the structural chromosomal abnormalities (55.5% vs to 44.5%. The numerical chromosomal abnormalities with an incidence of 47.9% trisomy 21, 14.1% trisomy 18, 8.7% Klinefelter Syndrome, 7% monosomy X, 6.6% trisomy 13, 1.7% trisomy X, 1.7% XYY Syndrom, 10% mosaics and the others represented the remaining. Of the structural abnormalities 35% were balanced while the 4% were unbalanced. The frequent structural abnormalities were 25.3% 46,XX/XY, inv(9(p11;q12 and 19.5% 46,XX/XY, inv(9(p11;q13. Balanced and unbalanced translocations, deletions and duplications were alsocontributed to chromosomal abnormalities in lesser extent. CONCLUSIONS: Corollary to literature and our findings revealed that the advanced maternal age and certain

  1. Evaluation of the cytogenetical results of 4707 cases diagnosed with amniocentesis.

    Directory of Open Access Journals (Sweden)

    Ayfer Pazarbasi

    2011-03-01

    Full Text Available PURPOSE: Amniocentesis is a very crucial diagnostic procedure for preventing the birth of genetically defective fetuses in order to decrease the prevalence of genetic diseases in populations. METHODS: The karyotyping of 4707 fetuses was carried out in our department during the years of 2000-2009 from the samples of amniotic fluids, CVS, fetal tissues and urines which were sent from departments of Gynecology and Obstetrics of Balcali Hospital and other regional hospitals. RESULTS: The mean maternel and gestational age of pregnant women evaluated for prenatal diagnosis were 29.1 years of age and 18.8 months respectively. Among 4707 fetuses that were karyotyped; 2284 fetuses were males and 2205 fetuses were females and 218 (4.63% fetuses had various chromosomal abnormalities. Consequently, male to female ratio of fetuses that were examined was 1.03. The advanced maternal age pregnancies followed by positive triplescreening were related to the highest rate of chromosomal abnormalities. The mean age of pregnant women having fetuses with chromosomal abnormalities was found to be 33 years of age which suggest that fetal chromosomal abnormalities were associated with maternal age. Numerical chromosomal abnormalities predominated the structural chromosomal abnormalities (55.5% vs to 44.5%. The numerical chromosomal abnormalities with an incidence of 47.9% trisomy 21, 14.1% trisomy 18, 8.7% Klinefelter Syndrome, 7% monosomy X, 6.6% trisomy 13, 1.7% trisomy X, 1.7% XYY Syndrom, 10% mosaics and the others represented the remaining. Of the structural abnormalities 35% were balanced while the 4% were unbalanced. The frequent structural abnormalities were 25.3% 46,XX/XY, inv(9(p11;q12 and 19.5% 46,XX/XY, inv(9(p11;q13. Balanced and unbalanced translocations, deletions and duplications were alsocontributed to chromosomal abnormalities in lesser extent. CONCLUSIONS: Corollary to literature and our findings revealed that the advanced maternal age and certain

  2. Quality Assessment of Studies Published in Open Access and Subscription Journals: Results of a Systematic Evaluation.

    Science.gov (United States)

    Pastorino, Roberta; Milovanovic, Sonja; Stojanovic, Jovana; Efremov, Ljupcho; Amore, Rosarita; Boccia, Stefania

    2016-01-01

    Along with the proliferation of Open Access (OA) publishing, the interest for comparing the scientific quality of studies published in OA journals versus subscription journals has also increased. With our study we aimed to compare the methodological quality and the quality of reporting of primary epidemiological studies and systematic reviews and meta-analyses published in OA and non-OA journals. In order to identify the studies to appraise, we listed all OA and non-OA journals which published in 2013 at least one primary epidemiologic study (case-control or cohort study design), and at least one systematic review or meta-analysis in the field of oncology. For the appraisal, we picked up the first studies published in 2013 with case-control or cohort study design from OA journals (Group A; n = 12), and in the same time period from non-OA journals (Group B; n = 26); the first systematic reviews and meta-analyses published in 2013 from OA journals (Group C; n = 15), and in the same time period from non-OA journals (Group D; n = 32). We evaluated the methodological quality of studies by assessing the compliance of case-control and cohort studies to Newcastle and Ottawa Scale (NOS) scale, and the compliance of systematic reviews and meta-analyses to Assessment of Multiple Systematic Reviews (AMSTAR) scale. The quality of reporting was assessed considering the adherence of case-control and cohort studies to STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) checklist, and the adherence of systematic reviews and meta-analyses to Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) checklist. Among case-control and cohort studies published in OA and non-OA journals, we did not observe significant differences in the median value of NOS score (Group A: 7 (IQR 7-8) versus Group B: 8 (7-9); p = 0.5) and in the adherence to STROBE checklist (Group A, 75% versus Group B, 80%; p = 0.1). The results did not change after adjustment

  3. Bristol Girls Dance Project Feasibility Trial: outcome and process evaluation results

    Directory of Open Access Journals (Sweden)

    Jago Russell

    2012-07-01

    Full Text Available Abstract Background Many adolescent girls do not engage in sufficient physical activity (PA. This study examined the feasibility of conducting a cluster randomized controlled trial (RCT to evaluate an after-school dance program to increase PA among 11–12 year old girls in Bristol, UK. Methods Three-arm, cluster RCT. Three secondary schools were assigned to intervention arm. Intervention participants received a 9-week dance program with 2, 90-minute dance classes per week. Participants at 2 control schools received incentives for data collection. Participants at 2 additional control schools received incentives and a delayed dance workshop. Accelerometer data were collected at baseline (time 0, during the last week of the dance program (time 1 and 20 weeks after the start of the study (time 2. Weekly attendance, enjoyment and perceived exertion were assessed in intervention participants. Post-study qualitative work was conducted with intervention participants and personnel. Results 40.1% of girls provided consent to be in the study. The mean number of girls attending at least one dance session per week ranged from 15.4 to 25.9. There was greater number of participants for whom accelerometer data were collected in control arms. The mean attendance was 13.3 sessions (maximum = 18. Perceived exertion ratings indicated that the girls did not find the sessions challenging. The dance teachers reported that the program content would benefit from revisions including less creative task time, a broader range of dance genres and improved behavioral management policies. At time 2, the 95% confidence intervals suggest between 5 and 12 minutes more weekday MVPA in the intervention group compared with the control incentives only group, and between 6 minutes fewer and 1 minute more compared with the control incentives plus workshop group. Between 14 and 24 schools would be required to detect a difference of 10 minutes in mean weekday MVPA between

  4. Evaluation of the Early Results of the Initial 500 Cardiac Operations Performed in a New Center

    Directory of Open Access Journals (Sweden)

    Turan Erdoğan

    2011-12-01

    Full Text Available Background: The initial 500 cases of a new center which is established in a province having no history of open heart surgery are evaluated with respect to mortality especially.Methods: A total of 500 patients underwent operations at our clinic between March 2008 and November 2009. Of these patients 373 (74.6% were male, 127 (25.4% were female and the mean age was 64.15±11.54. Four hundred eleven patients had coronary artery disease (19 had left ventricular aneurysm, 46 patients had coronary artery disease together with heart valve disease (of these 2 had ascending aortic aneurysm, 1 had left ventricular aneurysm, 1 had rupture of sinus valsalva aneurysm, 30 patients had valvular disease ( 1 had also patent ductus arteriosus, 4 patients had type 1 aortic dissection, 4 patients had ascending aortic aneurysm (3 had aortic valve disease, 4 patients had coarctation of the aorta, and 1 of the patients underwent surgery with the diagnosis of secundum atrial septal defect. Results: In-hospital mortality rate was 2% with 10 patients. The reasons of deaths were; low cardiac output in 3, renal insufficiency in 2, peroperative myocardial infarction in 2, bleeding in 1, lung complications in 1 and cardiac tamponade in 1. Fifteen patients (3% due to bleeding caused for surgical re-exploration. Postoperative atrial fibrillation developed in 97 patients (19.4%. Four patients (0.8% suffered wound infections on saphenous vein region, one patient (0.2% developed mediastinitis. Three patients (0.6% had neurological complications (two patients developed hemiplegia, one suffered from persistent tonic-clonic convultion. Prolonged entubation, prolonged intensive care unit stay and readmission to intensive care were other complications with rates of 20 (4%, 31(6.2% and 13(2.6% respectively. Conclusion: Our study showed that there is a strong relationship between peroperative myocard infarction and mortality, and patients who had diminished renal functions

  5. Preliminary Results From SILVVER '03 - Seismic Investigations of the Las Vegas Valley: Evaluating Risk

    Science.gov (United States)

    Snelson, C. M.; Sandru, J.; McEwan, D. J.; Hirsch, A.; Zaragoza, S. A.; Draa, A.; Hanson, A. D.; Kaip, G.; Harder, S. H.; Azevedo, S.; McKibben, W.; Rodgers, A.; Lewis, J. P.; Smith, D.; Rock, D.; McCallen, D.

    2003-12-01

    In August 2003, the University of Nevada Las Vegas (UNLV) with the assistance of the several other institutions acquired seismic refraction data and broadband data across the Las Vegas basin, NV. The SILVVER '03 (Seismic Investigations of the Las Vegas Valley: Evaluating Risk) project is in part a continuing effort to characterize the Las Vegas basin for strong ground motion. The objectives of this phase of the Las Vegas Valley Seismic Response (LVVSR) project were to acquire 3-D seismic data across the basin to define the geometry and structure in the sub-surface; to identify sub-basins, which can focus energy in the basin; and test the current basin model, which shows that the northeastern portion of the basin is as deep as 5 km of unconsolidated basin fill and has increased amplification. The experiment consisted of two seismic refraction profiles of about 55 km in length each. One profile extended from the northeast, across the Las Vegas Valley Shear Zone and the transition from the deep to shallow portions of the basin to the southwest. The second profile extended from the southeast from Frenchman Mountain to the northwest towards the Nevada Test Site along a corridor that is thought to focus energy into the Las Vegas Valley. Station spacing along the profile was nominally 100 to 200 m and shot point spacing was on the order of 10 km. There were 8 shots that were successfully recorded ranging in size from 50 to 1000 lb. The overall quality of the data is very high, especially since the majority of the instruments were deployed in the urban area. Initial results show that the basin can be characterized by an average velocity of 4 km/s while the transition into the crust indicates there is a dramatic velocity increase to 6 km/s at the basin/bedrock contact. The data from this experiment will be used to produce a 3-D tomographic velocity model of the Las Vegas basin. In addition to the seismic refraction profiles, we set out 6 broadband stations across the Valley

  6. Evaluating the Economic Impact of Smart Care Platforms: Qualitative and Quantitative Results of a Case Study.

    Science.gov (United States)

    Vannieuwenborg, Frederic; Van der Auwermeulen, Thomas; Van Ooteghem, Jan; Jacobs, An; Verbrugge, Sofie; Colle, Didier

    2016-10-31

    In response to the increasing pressure of the societal challenge because of a graying society, a gulf of new Information and Communication Technology (ICT) supported care services (eCare) can now be noticed. Their common goal is to increase the quality of care while decreasing its costs. Smart Care Platforms (SCPs), installed in the homes of care-dependent people, foster the interoperability of these services and offer a set of eCare services that are complementary on one platform. These eCare services could not only result in more quality care for care receivers, but they also offer opportunities to care providers to optimize their processes. The objective of the study was to identify and describe the expected added values and impacts of integrating SCPs in current home care delivery processes for all actors. In addition, the potential economic impact of SCP deployment is quantified from the perspective of home care organizations. Semistructured and informal interviews and focus groups and cocreation workshops with service providers, managers of home care organizations, and formal and informal care providers led to the identification of added values of SCP integration. In a second step, process breakdown analyses of home care provisioning allowed defining the operational impact for home care organization. Impacts on 2 different process steps of providing home care were quantified. After modeling the investment, an economic evaluation compared the business as usual (BAU) scenario versus the integrated SCP scenario. The added value of SCP integration for all actors involved in home care was identified. Most impacts were qualitative such as increase in peace of mind, better quality of care, strengthened involvement in care provisioning, and more transparent care communication. For home care organizations, integrating SCPs could lead to a decrease of 38% of the current annual expenses for two administrative process steps namely, care rescheduling and the billing for

  7. Quality Assessment of Studies Published in Open Access and Subscription Journals: Results of a Systematic Evaluation.

    Directory of Open Access Journals (Sweden)

    Roberta Pastorino

    Full Text Available Along with the proliferation of Open Access (OA publishing, the interest for comparing the scientific quality of studies published in OA journals versus subscription journals has also increased. With our study we aimed to compare the methodological quality and the quality of reporting of primary epidemiological studies and systematic reviews and meta-analyses published in OA and non-OA journals.In order to identify the studies to appraise, we listed all OA and non-OA journals which published in 2013 at least one primary epidemiologic study (case-control or cohort study design, and at least one systematic review or meta-analysis in the field of oncology. For the appraisal, we picked up the first studies published in 2013 with case-control or cohort study design from OA journals (Group A; n = 12, and in the same time period from non-OA journals (Group B; n = 26; the first systematic reviews and meta-analyses published in 2013 from OA journals (Group C; n = 15, and in the same time period from non-OA journals (Group D; n = 32. We evaluated the methodological quality of studies by assessing the compliance of case-control and cohort studies to Newcastle and Ottawa Scale (NOS scale, and the compliance of systematic reviews and meta-analyses to Assessment of Multiple Systematic Reviews (AMSTAR scale. The quality of reporting was assessed considering the adherence of case-control and cohort studies to STrengthening the Reporting of OBservational studies in Epidemiology (STROBE checklist, and the adherence of systematic reviews and meta-analyses to Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA checklist.Among case-control and cohort studies published in OA and non-OA journals, we did not observe significant differences in the median value of NOS score (Group A: 7 (IQR 7-8 versus Group B: 8 (7-9; p = 0.5 and in the adherence to STROBE checklist (Group A, 75% versus Group B, 80%; p = 0.1. The results did not change after

  8. FEFTRA {sup TM} verification. Update 2013

    Energy Technology Data Exchange (ETDEWEB)

    Loefman, J. [VTT Technical Research Centre of Finland, Espoo (Finland); Meszaros, F. [The Relief Lab., Harskut, (Hungary)

    2013-12-15

    FEFTRA is a finite element program package developed at VTT for the analyses of groundwater flow in Posiva's site evaluation programme that seeks a final repository for spent nuclear fuel in Finland. The code is capable of modelling steady-state or transient groundwater flow, solute transport and heat transfer as coupled or separate phenomena. Being a typical research tool used only by its developers, the FEFTRA code lacked long of a competent testing system and precise documentation of the verification of the code. In 2006 a project was launched, in which the objective was to reorganise all the material related to the existing verification cases and place them into the FEFTRA program path under the version-control system. The work also included development of a new testing system, which automatically calculates the selected cases, checks the new results against the old approved results and constructs a summary of the test run. All the existing cases were gathered together, checked and added into the new testing system. The documentation of each case was rewritten with the LATEX document preparation system and added into the testing system in a way that the whole test documentation (this report) could easily be generated in a postscript or pdf-format. The current report is the updated version of the verification report published in 2007. At the moment the report includes mainly the cases related to the testing of the primary result quantities (i.e. hydraulic head, pressure, salinity concentration, temperature). The selected cases, however, represent typical hydrological applications, in which the program package has been and will be employed in the Posiva's site evaluation programme, i.e. the simulations of groundwater flow, solute transport and heat transfer as separate or coupled phenomena. The comparison of the FEFTRA results to the analytical, semianalytical and/or other numerical solutions proves the capability of FEFTRA to simulate such problems

  9. Finite element model updating using bayesian framework and modal properties

    CSIR Research Space (South Africa)

    Marwala, T

    2005-01-01

    Full Text Available Finite element (FE) models are widely used to predict the dynamic characteristics of aerospace structures. These models often give results that differ from measured results and therefore need to be updated to match measured results. Some...

  10. CESM/CAM5 improvement and application: comparison and evaluation of updated CB05_GE and MOZART-4 gas-phase mechanisms and associated impacts on global air quality and climate

    Science.gov (United States)

    He, J.; Zhang, Y.; Tilmes, S.; Emmons, L.; Lamarque, J.-F.; Glotfelty, T.; Hodzic, A.; Vitt, F.

    2015-12-01

    Atmospheric chemistry plays a key role in determining the amounts and distributions of oxidants and gaseous precursors that control the formation of secondary gaseous and aerosol pollutants; all of those species can interact with the climate system. To understand the impacts of different gas-phase mechanisms on global air quality and climate predictions, in this work, a comprehensive comparative evaluation is performed using the Community Atmosphere Model (CAM) Version 5 with comprehensive tropospheric and stratospheric chemistry (CAM5-chem) within the Community Earth System Model (CESM) with the two most commonly used gas-phase chemical mechanisms: the 2005 Carbon Bond mechanism with Global Extension (CB05_GE) and the Model of OZone and Related chemical Tracers version 4 (MOZART-4) mechanism with additional updates (MOZART-4x). MOZART-4x and CB05_GE use different approaches to represent volatile organic compounds (VOCs) and different surrogates for secondary organic aerosol (SOA) precursors. MOZART-4x includes a more detailed representation of isoprene chemistry compared to CB05_GE. CB05_GE includes additional oxidation of SO2 by O3 over the surface of dust particles, which is not included in MOZART-4x. The results show that the two CAM5-chem simulations with CB05_GE and MOZART-4x predict similar chemical profiles for major gases (e.g., O3, CO, and NOx) compared to the aircraft measurements, with generally better agreement for NOy profiles by CB05_GE than MOZART-4x. The concentrations of SOA at four sites in the continental US (CONUS) and organic carbon (OC) over the IMPROVE sites are well predicted by MOZART-4x (with normalized mean biases (NMBs) of -1.9 and 2.1 %, respectively) but moderately underpredicted by CB05_GE (with NMBs of -23.1 and -20.7 %, respectively). This is mainly due to the higher biogenic emissions and OH levels simulated with MOZART-4x than with CB05_GE. The concentrations of OC over Europe are largely underpredicted by both MOZART-4x and CB05

  11. Cast Stone Oxidation Front Evaluation: Preliminary Results For Samples Exposed To Moist Air

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C. A.; Almond, P. M.

    2013-11-26

    chromium and technetium (i.e., effective Cr and Tc oxidation fronts). Residual reduction capacity in the oxidized region of the test samples indicates that the remaining reduction capacity is not effective in re-reducing Cr(VI) or Tc(VII) in the presence of oxygen. Depth discrete sampling and leaching is a useful for evaluating Cast Stone and other chemically reducing waste forms containing ground granulated blast furnace slag (GGBFS) or other reduction / sequestration reagents to control redox sensitive contaminant chemistry and leachability in the near surface disposal environment. Based on results presented in this report, reduction capacity measured by the Angus-Glasser Ce(IV) method is not an appropriate or meaningful parameter for determining or predicting Tc and Cr oxidation / retentions, speciation, or solubilities in cementitious materials such as Cast Stone. A model for predicting Tc(IV) oxidation to soluble Tc(VII) should consider the waste form porosity (pathway for oxygen ingress), oxygen source, and the contaminant specific oxidation rates and oxidation fronts. Depth discrete sampling of materials exposed to realistic conditions in combination with short term leaching of crushed samples has potential for advancing the understanding of factors influencing performance. This information can be used to support conceptual model development.

  12. Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial

    DEFF Research Database (Denmark)

    Punthakee, Z; Bosch, J; Dagenais, G

    2012-01-01

    AIMS/OBJECTIVE: Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglit......AIMS/OBJECTIVE: Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs...

  13. Results of the Clarus demonstrations : evaluation of enhanced road weather forecasting enabled by Clarus.

    Science.gov (United States)

    2011-06-14

    This document is the final report of an evaluation of Clarus-enabled enhanced road weather forecasting used in the Clarus Demonstrations. : This report examines the use of Clarus data to enhance four types of weather models and forecasts: The Local A...

  14. An Evaluation of an Innovative Drug Education Program: First Year Results.

    Science.gov (United States)

    Schaps, Eric; And Others

    An innovative drug education course was taught to seventh and eighth graders and evaluated in a true experiment. Students learned Lasswell's framework for understanding human needs and motives, a systematic decision-making procedure, and information about the pharmacological, psychological, and social consequences of licit and illicit drug use.…

  15. Formative usability evaluation of a web-based insulin self-titration system: preliminary results

    NARCIS (Netherlands)

    Gude, Wouter T.; Simon, Airin C. R.; Peute, Linda W. P.; Holleman, Frits; Hoekstra, Joost B. L.; Peek, Niels; Jaspers, Monique W. M.

    2012-01-01

    We developed a web-based system supporting patients in insulin self-titration and their caregivers in monitoring patients' self-management activities. Since usability flaws could cause user attrition and compromise patient safety, we evaluated the system's usability prior to its implementation in

  16. Process evaluation results from the HEALTHY nutrition intervention to modify the total school food environment

    Science.gov (United States)

    The process evaluation of HEALTHY, a large multi-center trial to decrease type 2 diabetes mellitus in middle school children, monitored the implementation of the intervention to ascertain the extent that components were delivered and received as intended. The purpose of this article is to report the...

  17. Female Sexual Abuse Evaluation in the Urological Practice : Results of a Dutch Survey

    NARCIS (Netherlands)

    Beck, Jack; Bekker, Milou; Van Driel, Mels; Putter, Hein; Pelger, Rob; Nijeholt, A. A. B. Lycklama A.; Elzevier, Henk Willem

    Introduction. There is a strong association between urological complaints and a history of sexual abuse, especially in females. It is not known whether urologists integrate these facts in their daily practice. Aim. To evaluate whether Dutch urologists address the issues of sexual abuse in their

  18. Implementation of a Coaching Program for School Principals: Evaluating Coaches' Strategies and the Results

    Science.gov (United States)

    Huff, Jason; Preston, Courtney; Goldring, Ellen

    2013-01-01

    We present a multi-phase coaching model that was implemented to help principals improve their instructional leadership practices. We then discuss a rubric based on this coaching model that we used to evaluate coaches' implementation of key model phases and to identify principals' responses to the coaching. After presenting the…

  19. Evaluation of Clinical Results and Complications of Structural Allograft Reconstruction after Bone Tumor Surgery

    Directory of Open Access Journals (Sweden)

    Mohammad Gharedaghi

    2016-07-01

    Full Text Available Background: Massive bone allograft is an option in cases of limb preservation and reconstruction after massive benign and malignant bone tumor resection. The purpose of this study was to analyze the outcome of these procedures at Imam Reza Hospital, Mashhad University of Medical Sciences. Methods: In this study, 113 cases have been presented. Eleven cases were excluded (patients has a traumatic defect or they passed away before the completion of the study’s two-year follow up period. Each patient completed a questionnaire, went through a physical examination and, if indicated, X-ray information was collected. The patients were divided into three groups: chemotherapy, chemotherapy plus radiation therapy, and no-adjuvant-therapy. Results: Fifty-four cases were male and the mean age was 24.5±5.39. The number of cases and indications for surgery were: 33 cases of aggressive benign tumors or low grade malignant bone tumors (large bone defects including 16 germ cell tumors, eight aneurysmal bone cysts, five low grade osteosarcomas, and four chondrosarcomas. Another 69 cases were high-grade malignant bone tumors including 42 osteosarcomas, 21 Ewing’s sarcoma, and six other high grade osteosarcomas. Patients were divided into three groups: the first group received no adjuvant therapy, the second group received chemotherapy, and the third group received chemotherapy plus radiotherapy. The location of tumors were as follows: eight cases in the pelvic bone, 12 in the proximal femur, 18 in the femoral shaft, 36 in the distal femur, 12 in the proximal tibia, and 16 in the humeral bone. The 12 cases of proximal femoral defects were reconstructed by allograft composite prosthesis, 18 diaphyseal defects with intercalary allograft, and 36 distal femoral defects were reconstructed using osteoarticular allograft. The rate of deep infection was 7:8% (eight patients and in this regard, we found a significant difference among the three groups, such that most

  20. HPLC evaluation of the minor lipid components of by-products resulting from edible oil processing

    Directory of Open Access Journals (Sweden)

    EL-Shami, Safinaz Mohamed M.

    2006-12-01

    Full Text Available An analytical evaluation of some by-products resulting from edible oil refining processing steps has been carried out. By-product samples were taken from four different local refineries that apply chemical refining technology. Pretreatment of the representative samples of the by-products were done prior to analysis followed by chromatographic isolation and derivatization of the minor components, namely, free and acylated sterol (FS and AS as well as free and acylated sterylglycosides (FSG and ASG. However, tocopherols were directly determined in the pretreated samples. HPLC, using different detectors, was carried out for the determination of these minor components. Several authors have focused on the analysis of sterols and sterol esters, as well as tocopherols in the refining byproducts; however sterylglycosides, as biologically important components, have not been dealt with. This study throws light on the by – products enriched with certain minor components to be possibly utilized as sources for such components. Also, the role of the conditions of the refining steps followed in removing these valuable minor components from oils was discussed. It was found that soapstock samples contained various amounts of total tocopherols ranging from 80 to 230ppm; total FS and AS ranged from 240 to 4000 mg/100g while total FSG and ASG ranged from 1120 to 6375 mg/100g. In the case of deodorization distillate samples total tocopherols ranged from 960 to 7360ppm; total FS and AS ranged from 1020 to 4160 mg/100g and total FSG, ASG ranged from 395 to 880 mg/100g.El trabajo realiza una evaluación analítica de algunos subproductos resultantes del la refinación de aceites comestibles. Las muestras procedieron de 4 plantas que aplicaban refinación química. Después de un pretratamiento de las muestras estas se sometieron a un análisis cromatográfico para el aislamiento y derivatización de los siguientes componentes minoritarios: esteroles libres y

  1. Risk Assessment Update: Russian Segment

    Science.gov (United States)

    Christiansen, Eric; Lear, Dana; Hyde, James; Bjorkman, Michael; Hoffman, Kevin

    2012-01-01

    BUMPER-II version 1.95j source code was provided to RSC-E- and Khrunichev at January 2012 MMOD TIM in Moscow. MEMCxP and ORDEM 3.0 environments implemented as external data files. NASA provided a sample ORDEM 3.0 g."key" & "daf" environment file set for demonstration and benchmarking BUMPER -II v1.95j installation at the Jan-12 TIM. ORDEM 3.0 has been completed and is currently in beta testing. NASA will provide a preliminary set of ORDEM 3.0 ".key" & ".daf" environment files for the years 2012 through 2028. Bumper output files produced using the new ORDEM 3.0 data files are intended for internal use only, not for requirements verification. Output files will contain these words ORDEM FILE DESCRIPTION = PRELIMINARY VERSION: not for production. The projectile density term in many BUMPER-II ballistic limit equations will need to be updated. Cube demo scripts and output files delivered at the Jan-12 TIM have been updated for the new ORDEM 3.0 data files. Risk assessment results based on ORDEM 3.0 and MEM will be presented for the Russian Segment (RS) of ISS.

  2. Evaluation of stress resultant of offshore jacket platform using neural network

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.; Hegde, G.; Gupta, K.G.

    . This paper deals with the prediction of stress resultant deflections of fixed offshore platform to the varying environmental loading conditions using neural networks. The manual estimation of stress resultant to the varying loading conditions involves tedious...

  3. Indoor Spatial Updating with Reduced Visual Information.

    Directory of Open Access Journals (Sweden)

    Gordon E Legge

    Full Text Available Spatial updating refers to the ability to keep track of position and orientation while moving through an environment. People with impaired vision may be less accurate in spatial updating with adverse consequences for indoor navigation. In this study, we asked how artificial restrictions on visual acuity and field size affect spatial updating, and also judgments of the size of rooms.Normally sighted young adults were tested with artificial restriction of acuity in Mild Blur (Snellen 20/135 and Severe Blur (Snellen 20/900 conditions, and a Narrow Field (8° condition. The subjects estimated the dimensions of seven rectangular rooms with and without these visual restrictions. They were also guided along three-segment paths in the rooms. At the end of each path, they were asked to estimate the distance and direction to the starting location. In Experiment 1, the subjects walked along the path. In Experiment 2, they were pushed in a wheelchair to determine if reduced proprioceptive input would result in poorer spatial updating.With unrestricted vision, mean Weber fractions for room-size estimates were near 20%. Severe Blur but not Mild Blur yielded larger errors in room-size judgments. The Narrow Field was associated with increased error, but less than with Severe Blur. There was no effect of visual restriction on estimates of distance back to the starting location, and only Severe Blur yielded larger errors in the direction estimates. Contrary to expectation, the wheelchair subjects did not exhibit poorer updating performance than the walking subjects, nor did they show greater dependence on visual condition.If our results generalize to people with low vision, severe deficits in acuity or field will adversely affect the ability to judge the size of indoor spaces, but updating of position and orientation may be less affected by visual impairment.

  4. Research Protocol - An Evaluation of False Positive HIV Results due to Testing Errors

    OpenAIRE

    Maparo, Tatenda; Mungofa, Stanley; Bara, Hilda T.; Chirisa, Florence

    2014-01-01

    An unacceptably high frequency of false positive HIV test results has been reported in various settings. Given the severity and implications of an HIV+ diagnosis, a false positive result is likely to be psychologically traumatic and may result in inappropriate and potentially harmful treatment. The current HIV testing algorithm being used in Zimbabwe does not include repeat testing for HIV positive results, and it is not currently known whether testing errors are leading to false positive dia...

  5. Results of Field Survey to Evaluate an Experimental Set of Officer Duty Modules

    Science.gov (United States)

    1974-01-01

    that field testing and evaluations should be completed before their designation as duty nodules. -3- rJ SURVEY PROCEDURES Pre- Tesis Pre-tests of...Ai: ct I ,ii .1) ..𔃻 I:II m IM in (1 ’.I „ 1(1 -/jv, :• i «Ti •.l.CX, /fi i i . M lUi . _ 111 171 111 Ml A«.-... i CMMI I

  6. Results from Evaluation of Three Commercial Off the shelf Face Recognition Systems on Chokepoint Dataset

    Science.gov (United States)

    2014-09-01

    PSTP 03-401BIOM, was supported by the Canadian Safety and Security Program ( CSSP ) which is led by Defence Research and Development Canada’s Centre for...Investigation, National Institute of Standards and Technology, UK Home Office; University of Ottawa, Université Québec (ÉTS). The CSSP is a federally...evaluation Community of Practice: Biometrics and Identity Management Canada Safety and Security ( CSSP ) investment priorities: 1. Capability area: P1.6

  7. Evaluation of the Integrity of Deep Rock Masses Using Results of Digital Borehole Televiewers

    Science.gov (United States)

    Guo, Hao-Sen; Feng, Xia-Ting; Li, Shao-Jun; Yang, Cheng-Xiang; Yao, Zhi-Bin

    2017-06-01

    Rock mass integrity is regarded as an important index to evaluate rock mass quality. Core drilling technology is one of the effective methods used for this. To overcome the problem of core discing and core breakage from the drilling process, a new evaluation method was proposed: a rock mass integrity index (RMIBT) based on high-definition digital borehole televiewer data. The RMIBT values were obtained by measuring the mass proportions of the length of the rock mass without macroscopic fractures on the borehole wall. Their scoring criteria were determined based on rock quality designation. It was applied in multiple deep rock excavations and therefore proved to be useful, especially where core discing occurs, in specific spatial distributions of structural planes, as well as logging errors from core breakages induced by drilling. In addition, the RMIBT can be used to assess dynamically the integrity of macroscopic rock masses and the evolution of fractures in the excavation damaged zone, thus providing a basis for the evaluation of rock masses in deep rock excavations.

  8. Lake Erie phosphorus loading and Cladophora updates

    Science.gov (United States)

    The presentation will focus on updates or progress being made on each Phosphorus Loadings and Cladophora for Lake Erie. The format will give a brief summary of data, findings, and results that were used by the Great Lakes Water Quality Agreement (GLWQA) Annex 4 Nutrients Modeli...

  9. Web Browser Security Update Effectiveness

    Science.gov (United States)

    Duebendorfer, Thomas; Frei, Stefan

    We analyze the effectiveness of different Web browser update mechanisms on various operating systems; from Google Chrome's silent update mechanism to Opera's update requiring a full re-installation. We use anonymized logs from Google's world wide distributed Web servers. An analysis of the logged HTTP user-agent strings that Web browsers report when requesting any Web page is used to measure the daily browser version shares in active use. To the best of our knowledge, this is the first global scale measurement of Web browser update effectiveness comparing four different Web browser update strategies including Google Chrome. Our measurements prove that silent updates and little dependency on the underlying operating system are most effective to get users of Web browsers to surf the Web with the latest browser version.

  10. General vs health specialized search engine: a blind comparative evaluation of top search results.

    Science.gov (United States)

    Pletneva, Natalia; Ruiz de Castaneda, Rafael; Baroz, Frederic; Boyer, Celia

    2014-01-01

    This paper presents the results of a blind comparison of top ten search results retrieved by Google.ch (French) and Khresmoi for everyone, a health specialized search engine. Participants--students of the Faculty of Medicine of the University of Geneva had to complete three tasks and select their preferred results. The majority of the participants have largely preferred Google results while Khresmoi results showed potential to compete in specific topics. The coverage of the results seems to be one of the reasons. The second being that participants do not know how to select quality and transparent health web pages. More awareness, tools and education about the matter is required for the students of Medicine to be able to efficiently distinguish trustworthy online health information.

  11. A hierarchical updating method for finite element model of airbag buffer system under landing impact

    Directory of Open Access Journals (Sweden)

    He Huan

    2015-12-01

    Full Text Available In this paper, we propose an impact finite element (FE model for an airbag landing buffer system. First, an impact FE model has been formulated for a typical airbag landing buffer system. We use the independence of the structure FE model from the full impact FE model to develop a hierarchical updating scheme for the recovery module FE model and the airbag system FE model. Second, we define impact responses at key points to compare the computational and experimental results to resolve the inconsistency between the experimental data sampling frequency and experimental triggering. To determine the typical characteristics of the impact dynamics response of the airbag landing buffer system, we present the impact response confidence factors (IRCFs to evaluate how consistent the computational and experiment results are. An error function is defined between the experimental and computational results at key points of the impact response (KPIR to serve as a modified objective function. A radial basis function (RBF is introduced to construct updating variables for a surrogate model for updating the objective function, thereby converting the FE model updating problem to a soluble optimization problem. Finally, the developed method has been validated using an experimental and computational study on the impact dynamics of a classic airbag landing buffer system.

  12. Empirical testing of forecast update procedure forseasonal products

    DEFF Research Database (Denmark)

    Wong, Chee Yew; Johansen, John

    2008-01-01

    Updating of forecasts is essential for successful collaborative forecasting, especially for seasonal products. This paper discusses the results of a theoretical simulation and an empirical test of a proposed time-series forecast updating procedure. It involves a two-stage longitudinal case study...... of a toy supply chain. The theoretical simulation involves historical weekly consumer demand data for 122 toy products. The empirical test is then carried out in real-time with 291 toy products. The results show that the proposed forecast updating procedure: 1) reduced forecast errors of the annual...... consumer demand, 2) determined timing for the commitment to subsequent replenishment during the selling seasons within acceptable forecast uncertainty, and 3) facilitated collaborative forecasting with more accurate forecast updates. However, during the empirical test, the forecast updating procedure...

  13. Context updates are hierarchical

    Directory of Open Access Journals (Sweden)

    Anton Karl Ingason

    2016-10-01

    Full Text Available This squib studies the order in which elements are added to the shared context of interlocutors in a conversation. It focuses on context updates within one hierarchical structure and argues that structurally higher elements are entered into the context before lower elements, even if the structurally higher elements are pronounced after the lower elements. The crucial data are drawn from a comparison of relative clauses in two head-initial languages, English and Icelandic, and two head-final languages, Korean and Japanese. The findings have consequences for any theory of a dynamic semantics.

  14. Effectiveness of Autologous Fat Grafting in Adherent Scars: Results Obtained by a Comprehensive Scar Evaluation Protocol.

    Science.gov (United States)

    Jaspers, Mariëlle E H; Brouwer, Katrien M; van Trier, Antoine J M; Groot, Marloes L; Middelkoop, Esther; van Zuijlen, Paul P M

    2017-01-01

    Nowadays, patients normally survive severe traumas such as burn injuries and necrotizing fasciitis. Large skin defects can be closed but the scars remain. Scars may become adherent to underlying structures when the subcutical fat layer is damaged. Autologous fat grafting provides the possibility of reconstructing a functional sliding layer underneath the scar. Autologous fat grafting is becoming increasingly popular for scar treatment, although large studies using validated evaluation tools are lacking. The authors therefore objectified the effectiveness of single-treatment autologous fat grafting on scar pliability using validated scar measurement tools. Forty patients with adherent scars receiving single-treatment autologous fat grafting were measured preoperatively and at 3-month follow-up. The primary outcome parameter was scar pliability, measured using the Cutometer. Scar quality was also evaluated by the Patient and Observer Scar Assessment Scale and the DSM II ColorMeter. To prevent selection bias, measurements were performed following a standardized algorithm. The Cutometer parameters elasticity and maximal extension improved 22.5 percent (p Scar Assessment Scale scores improved from 3.6 to 2.9 on the observer scale, and from 5.1 to 3.8 on the patient scale (both p scar and normal skin remained unaltered. For the first time, the effect of autologous fat grafting on functional scar parameters was ascertained using a comprehensive scar evaluation protocol. The improved scar pliability supports the authors' hypothesis that the function of the subcutis can be restored to a certain extent by single-treatment autologous fat grafting. Therapeutic, IV.

  15. Results of short-term corrosion evaluation tests at Raft River

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.L.

    1977-10-01

    Four categories of short-term materials evaluation tests were conducted in geothermal fluid from Raft River Geothermal Experiment, Well No. 1, to obtain corrosion data relevant to the design of the Raft River Thermal Loop Facility. Test programs are described and the testing philosophies are discussed. All materials and configurations which were tested are identified and details of posttest visual examinations are presented. The materials are then assigned to appropriate performance categories on the basis of test behavior, and the possible service limitations are appraised.

  16. Using X-ray computed tomography to evaluate the initial saturation resulting from different saturation procedures

    DEFF Research Database (Denmark)

    Christensen, Britt Stenhøj Baun; Wildenschild, D; Jensen, K.H.

    2006-01-01

    for saturation. Evaluation of the different enhanced saturation techniques was done with Xray computed tomography (CT) and gravimetrically. The use of CT scanning makes it possible to observe the spatial distribution of wetting and non-wetting phases in the porous medium in a non-destructive way. In this case...... with pressurized nitrogen between each saturation and allowed to saturate for the same length of time for all the different procedures. Both gravimetric measurements and CT attenuation levels showed that venting the sample with carbon dioxide prior to saturation clearly improved initial saturation whereas the use...

  17. [Results of the evaluation of German benchmarking networks funded by the Ministry of Health].

    Science.gov (United States)

    de Cruppé, Werner; Blumenstock, Gunnar; Fischer, Imma; Selbmann, Hans-Konrad; Geraedts, Max

    2011-01-01

    Nine out of ten demonstration projects on clinical benchmarking funded by the German Ministry of Health were evaluated. Project reports and interviews were uniformly analysed using a list of criteria and a scheme to categorize the realized benchmarking approach. At the end of the funding period four benchmarking networks had implemented all benchmarking steps, and six were continued after funding had expired. The improvement of outcome quality cannot yet be assessed. Factors promoting the introduction of benchmarking networks with regard to organisational and process aspects of benchmarking implementation were derived. Copyright © 2011. Published by Elsevier GmbH.

  18. Side-by-Side Testing of Water Heating Systems: Results from the 2013–2014 Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Colon, Carlos [Florida Solar Energy Center, Cocoa, FL (United States)

    2017-07-01

    The Florida Solar Energy Center (FSEC) completed a fourth year-long evaluation on residential hot water heating systems in a laboratory environment (east central Florida, hot-humid climate). The evaluation studied the performance of five hot water systems (HWS) plus a reference baseline system for each fuel, (i.e., electric and natural gas). Electric HWS consisted of two residential electric heat pump water heaters (HPWHs, 60 and 80 gallons), a solar thermal system using a polymer absorber (glazed) collector with 80-gallon storage and a duplicate 50-gallon standard electric water heater with added cap and wrap insulation. Baseline performance data were collected from a standard 50-gallon electric water heater of minimum code efficiency to compare energy savings. Similarly, a standard 40-gallon upright vented natural gas water heater served as baseline for the natural gas fuel category. The latter, having a larger jacket diameter [18 in., with an energy factor (EF) of 0.62] with increased insulation, replaced a former baseline (17 in. diameter, EF = 0.59) that served during three previous testing rotations (2009–2013). A high-efficiency, condensing natural gas hybrid water heater with 27-gallon buffered tank was also tested and compared against the gas baseline. All systems underwent testing simultaneously side-by-side under the criteria specified elsewhere in this report.

  19. Front-end Electronics for Unattended Measurement (FEUM). Results of Prototype Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, Ryan C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Keller, Daniel T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Morris, Scott J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smith, Leon E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-01

    The International Atomic Energy Agency (IAEA) deploys unattended monitoring systems to provide continuous monitoring of nuclear material within safeguarded facilities around the world. As the number of unattended monitoring instruments increases, the IAEA is challenged to become more efficient in the implementation of those systems. In 2010, the IAEA initiated the Front-End Electronics for Unattended Measurement (FEUM) project with the goals of greater flexibility in the interfaces to various sensors and data acquisition systems, and improved capabilities for remotely located sensors (e.g., where sensor and front-end electronics might be separated by tens of meters). In consultation with the IAEA, a technical evaluation of a candidate FEUM device produced by a commercial vendor has been performed. This evaluation assessed the device against the IAEA’s original technical specifications and a broad range of important parameters that include sensor types, cable lengths and types, industrial electromagnetic noise that can degrade signals from remotely located detectors, and high radiation fields. Testing data, interpretation, findings and recommendations are provided.

  20. Preliminary results of a new tool to evaluate cavernous body fibrosis following radical prostatectomy: penile elastography.

    Science.gov (United States)

    Hamidi, N; Altinbas, N K; Gokce, M I; Suer, E; Yagci, C; Baltaci, S; Turkolmez, K

    2017-09-01

    Development of cavernous tissue fibrosis due to neurovascular bundle damage during radical prostatectomy has been shown in many trials with invasive methods. In this study, we evaluated the changes in cavernous tissue elasticity by elastography in patients who underwent radical prostatectomy with or without neurovascular bundle preservation. Data from 65 patients underwent open retropubic radical prostatectomy between April 2014 and December 2015 was collected prospectively. Patients were grouped with respect to nerve-sparing status (non-, unilateral, and bilateral nerve sparing). International Index of Erectile Function scores, penile lengths, and elasticity scores were recorded at preoperative and postoperative follow-up visits (at 3rd and 6th months). The primary endpoint of the study was to evaluate the changes of the elasticity scores in all groups. Elasticity scores were measured with real-time elastography by a single experienced radiologist. Mean age, baseline total testosterone level, IIEF-5 score, elasticity scores of the cavernous body, and penile length were comparable in all groups. At postoperative 3rd and 6th months, statistically significant higher (in favor for fibrosis) mean cavernous body elasticity scores (p = 0.0001), lower mean IIEF-5 scores (p = 0.0001), and shorter penile lengths (p cavernous tissue fibrosis. © 2017 American Society of Andrology and European Academy of Andrology.

  1. Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial.

    Science.gov (United States)

    Kim, Dong-Wan; Mehra, Ranee; Tan, Daniel S W; Felip, Enriqueta; Chow, Laura Q M; Camidge, D Ross; Vansteenkiste, Johan; Sharma, Sunil; De Pas, Tommaso; Riely, Gregory J; Solomon, Benjamin J; Wolf, Jürgen; Thomas, Michael; Schuler, Martin; Liu, Geoffrey; Santoro, Armando; Sutradhar, Santosh; Li, Siyu; Szczudlo, Tomasz; Yovine, Alejandro; Shaw, Alice T

    2016-04-01

    ALK-rearranged non-small-cell lung cancer (NSCLC) is sensitive to ALK tyrosine kinase inhibitors (ALK inhibitors) such as crizotinib, but resistance invariably develops, often with progression in the brain. Ceritinib is a more potent ALK inhibitor than crizotinib in vitro, crosses the blood-brain barrier in vivo, and shows clinical responses in patients with crizotinib-resistant disease. We aimed to assess whole-body activity of ceritinib in both ALK inhibitor-pretreated and ALK inhibitor-naive patients with ALK-rearranged NSCLC. ASCEND-1 was an open-label, phase 1 trial that recruited patients from 20 academic hospitals or cancer centres in 11 countries in Europe, North America, and Asia-Pacific. Eligible patients were aged 18 years or older with ALK-rearranged locally advanced or metastatic cancer that had progressed despite standard therapy (or for which no effective standard therapy existed), who had at least one measurable lesion at baseline. The primary objective (to determine the maximum tolerated dose) has been reported previously. This updated analysis includes all patients with ALK-rearranged NSCLC given oral ceritinib at the recommended dose of 750 mg/day in the dose-escalation and expansion phases. Here we report the secondary outcomes of overall response, duration of response, and progression-free survival, analysed in all patients who received at least one 750 mg dose of ceritinib. Exploratory analyses included retrospective analysis of intracranial activity by independent neuroradiologists, in patients with untreated or locally treated neurologically stable brain metastases at baseline. Safety was assessed in all patients who received at least one dose of ceritinib. This study is no longer recruiting patients; however, treatment and follow-up are ongoing. This study is registered with ClinicalTrials.gov, number NCT01283516. Between Jan 24, 2011, and July 31, 2013, 255 patients were enrolled and received at least one dose of ceritinib 750 mg/day, of

  2. Examination of the properties of IMRT and VMAT beams and evaluation against pre-treatment quality assurance results.

    Science.gov (United States)

    Crowe, S B; Kairn, T; Middlebrook, N; Sutherland, B; Hill, B; Kenny, J; Langton, C M; Trapp, J V

    2015-03-21

    This study aimed to provide a detailed evaluation and comparison of a range of modulated beam evaluation metrics, in terms of their correlation with QA testing results and their variation between treatment sites, for a large number of treatments. Ten metrics including the modulation index (MI), fluence map complexity, modulation complexity score (MCS), mean aperture displacement (MAD) and small aperture score (SAS) were evaluated for 546 beams from 122 intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) treatment plans targeting the anus, rectum, endometrium, brain, head and neck and prostate. The calculated sets of metrics were evaluated in terms of their relationships to each other and their correlation with the results of electronic portal imaging based quality assurance (QA) evaluations of the treatment beams. Evaluation of the MI, MAD and SAS suggested that beams used in treatments of the anus, rectum, head and neck were more complex than the prostate and brain treatment beams. Seven of the ten beam complexity metrics were found to be strongly correlated with the results from QA testing of the IMRT beams (p beams with 100% specificity. However, few of the metrics are correlated with the results from QA testing of the VMAT beams, whether they were evaluated as whole 360° arcs or as 60° sub-arcs. Select evaluation of beam complexity metrics (at least MI, MCS and SAS) is therefore recommended, as an intermediate step in the IMRT QA chain. Such evaluation may also be useful as a means of periodically reviewing VMAT planning or optimiser performance.

  3. HANFORD DOUBLE SHELL TANK (DST) THERMAL & SEISMIC PROJECT BUCKLING EVALUATION METHODS & RESULTS FOR THE PRIMARY TANKS

    Energy Technology Data Exchange (ETDEWEB)

    MACKEY TC; JOHNSON KI; DEIBLER JE; PILLI SP; RINKER MW; KARRI NK

    2007-02-14

    This report documents a detailed buckling evaluation of the primary tanks in the Hanford double-shell waste tanks (DSTs), which is part of a comprehensive structural review for the Double-Shell Tank Integrity Project. This work also provides information on tank integrity that specifically responds to concerns raised by the Office of Environment, Safety, and Health (ES&H) Oversight (EH-22) during a review of work performed on the double-shell tank farms and the operation of the aging waste facility (AWF) primary tank ventilation system. The current buckling review focuses on the following tasks: (1) Evaluate the potential for progressive I-bolt failure and the appropriateness of the safety factors that were used for evaluating local and global buckling. The analysis will specifically answer the following questions: (a) Can the EH-22 scenario develop if the vacuum is limited to -6.6-inch water gage (w.g.) by a relief valve? (b) What is the appropriate factor of safety required to protect against buckling if the EH-22 scenario can develop? (c) What is the appropriate factor of safety required to protect against buckling if the EH-22 scenario cannot develop? (2) Develop influence functions to estimate the axial stresses in the primary tanks for all reasonable combinations of tank loads, based on detailed finite element analysis. The analysis must account for the variation in design details and operating conditions between the different DSTs. The analysis must also address the imperfection sensitivity of the primary tank to buckling. (3) Perform a detailed buckling analysis to determine the maximum allowable differential pressure for each of the DST primary tanks at the current specified limits on waste temperature, height, and specific gravity. Based on the I-bolt loads analysis and the small deformations that are predicted at the unfactored limits on vacuum and axial loads, it is very unlikely that the EH-22 scenario (i.e., progressive I-bolt failure leading to global

  4. Missing Links in Middle School: Developing Use of Disciplinary Relatedness in Evaluating Internet Search Results.

    Directory of Open Access Journals (Sweden)

    Frank C Keil

    Full Text Available In the "digital native" generation, internet search engines are a commonly used source of information. However, adolescents may fail to recognize relevant search results when they are related in discipline to the search topic but lack other cues. Middle school students, high school students, and adults rated simulated search results for relevance to the search topic. The search results were designed to contrast deep discipline-based relationships with lexical similarity to the search topic. Results suggest that the ability to recognize disciplinary relatedness without supporting cues may continue to develop into high school. Despite frequent search engine usage, younger adolescents may require additional support to make the most of the information available to them.

  5. Missing Links in Middle School: Developing Use of Disciplinary Relatedness in Evaluating Internet Search Results.

    Science.gov (United States)

    Keil, Frank C; Kominsky, Jonathan F

    2013-01-01

    In the "digital native" generation, internet search engines are a commonly used source of information. However, adolescents may fail to recognize relevant search results when they are related in discipline to the search topic but lack other cues. Middle school students, high school students, and adults rated simulated search results for relevance to the search topic. The search results were designed to contrast deep discipline-based relationships with lexical similarity to the search topic. Results suggest that the ability to recognize disciplinary relatedness without supporting cues may continue to develop into high school. Despite frequent search engine usage, younger adolescents may require additional support to make the most of the information available to them.

  6. [Results of Habitat Evaluation Procedures at Rocky Mountain Arsenal NWR : Spatial and Tabular Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains a basic map depicting the average of 5-7 transects/sections and 5 species, as well as a table detailing the preliminary results of habitat...

  7. Evaluating the Generalisability of Trial Results: Introducing a Centre- and Trial-Level Generalisability Index.

    Science.gov (United States)

    Gheorghe, Adrian; Roberts, Tracy; Hemming, Karla; Calvert, Melanie

    2015-11-01

    Few randomised controlled trials (RCTs) recruit centres representatively, which may limit the external validity of trial results. The aim of this study was to propose a proof-of-concept method of assessing the generalisability of the clinical and cost-effectiveness findings of a given RCT. We developed a generalisability index (Gix), informed by centre-level characteristics, as a measure of centre and trial representativeness. The centre-level Gix quantifies how representative a centre is in relation to its jurisdiction, e.g. a country or health authority. The trial-level Gix quantifies how representative trial recruitment is in relation to clinical practice in the jurisdiction. Taking a real-world RCT as a case study and assuming trial-wide results to represent 'true jurisdiction values', we used simulation methods to recreate 5000 RCTs and investigate the relationship between trial representativeness, reflected by the standardised trial-Gix, and the deviation of simulated trial results from the 'true values'. The simulation study provides evidence that trial results (odds ratio for the primary outcome and incremental quality-adjusted life-years) were influenced by the representativeness of the sample of recruiting centres. Simulated RCTs with the closest results to the 'true values' were those whose recruitment closely mirrored the jurisdiction-wide context. Results appeared robust to six alternative specifications of the Gix. Our findings suggest that an unrepresentative selection of centres limits the external validity of trial results. The Gix may be a valuable tool to help facilitate rational selection of trial centres and ensure the generalisability of results at the jurisdiction level.

  8. Medical student evaluation using augmented standardized patients: new development and results.

    Science.gov (United States)

    Sun, Bo; McKenzie, Frederic D; Garcia, Hector M; Hubbard, Thomas W; Ullian, John A; Gliva, Gayle A

    2007-01-01

    Standardized patients (SPs), individuals who realistically portray patients, are widely used in medical education to teach and assess communication skills, eliciting a history, performing a physical exam, and other important clinical skills. They are typically healthy individuals with few or no abnormal physical findings. One limitation is that each SP can only portray a limited set of physical symptoms. We have developed a functioning prototype that uses sound-based augmented reality (AR) to expand the capabilities of an SP to exhibit physically-manifested abnormalities. The previous research and evaluation of this prototype have been published in medicine meets virtual reality conference in January 2006. Current research has combined a virtual crackle sound with a healthy SP's real breath sound at end of inspiration in real time. The technology used is intended to correlate the inspiration timing of SP's. A learner will hear this simulated sound through an electronic-stethoscope wirelessly.

  9. Novel Scanning Lens Instrument for Evaluating Fresnel Lens Performance: Equipment Development and Initial Results (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Herrero, R.; Miller, D. C.; Kurtz, S. R.; Anton, I.; Sala, G.

    2013-07-01

    A system dedicated to the optical transmittance characterization of Fresnel lenses has been developed at NREL, in collaboration with the UPM. The system quantifies the optical efficiency of the lens by generating a performance map. The shape of the focused spot may also be analyzed to understand change in the lens performance. The primary instrument components (lasers and CCD detector) have been characterized to confirm their capability for performing optical transmittance measurements. Measurements performed on SoG and PMMA lenses subject to a variety of indoor conditions (e.g., UV and damp heat) identified differences in the optical efficiency of the evaluated lenses, demonstrating the ability of the Scanning Lens Instrument (SLI) to distinguish between the aged lenses.

  10. How you evaluate treatment results in low back pain patients depends on who the patient is

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2009-01-01

    ), the physical function and bodily pain subscales of the SF36, the Low Back Pain Rating Scale (LBPRS) and a numerical rating scale for pain (0-10) were completed by 191 patients from the primary and secondary sectors of the Danish health care system. Clinical change was estimated using a 7-point transition......Background The choice of an evaluative instrument in back pain patients is complicated because of lack of head-to-head comparisons of clinimetric properties of the various instruments. In addition, little is known about instrument behaviour in clinical subgroups. The objective of this study...... was to concurrently compare responsiveness and minimal clinically important differences (MCID) for commonly used pain scales and functional instruments in four subpopulations of LBP patients. Methods The Danish versions of the Oswestry Disability Index (ODI), the 23-item Roland Morris Disability Questionnaire (RMQ...

  11. Evaluation of subclinical atherosclerosis in migraine patients by ultrasound radiofrequency data technology: preliminary results.

    Science.gov (United States)

    Güneş Tatar, İdil; Ergun, Onur; Çeltikçi, Pınar; Kurt, Aydın; Yavaşoğlu, Neşe; Birgi, Erdem; Tatar, Tolga; Hekimoğlu, Baki

    2016-07-01

    Migraine is a headache disorder affecting approximately 12% of the population, predominantly female individuals. Migraine has been associated with vascular events such as stroke and cardiovascular disease. The close connection between these vascular disorders and atherosclerosis is well known. Carotid artery intima-media thickness (CAIMT) is a marker for detection of subclinical atherosclerosis. The present study is an analysis of the presence of subclinical atherosclerosis in migraine patients. CAIMT was evaluated in 25 female migraine patients and 27 female controls using innovative ultrasound (US) radiofrequency (RF) data technology. Mann-Whitney U test was used to compare measurements in patient and control groups. There was a statistically significant difference between mean CAIMT of migraine patients and control group (patherosclerosis compared to healthy individuals. CAIMT measurement with sonography can be utilized in follow-up to detect subclinical atherosclerosis.

  12. Magnetic resonance imaging of cleft palate patients after a palatoplasty to evaluate the nasopharyngeal results

    Energy Technology Data Exchange (ETDEWEB)

    Ikeda, Hiroto [Teikyo Univ., Tokyo (Japan). Faculty of Medicine; Kadomatsu, Koichi; Hori, Shigeru; Miyata, Masayuki; Kozono, Kikuo; Onizuka, Takuya

    1995-10-01

    Magnetic resonance imaging (MRI) of 16 cleft palate patients was undertaken after a palatoplasty to evaluate the postoperative status of the nasopharyngeal soft tissue, the soft palate, and a pharyngeal flap. As MRI revealed no abnormal findings in the nasopharyngeal muscle of all 16 patients, we concluded that the palatoplasty had normalized the positioning and volume of the levator veli muscle and the muscle sling of the palate. Further, although most of the pharyngeal flaps had an adequate inner muscle volume, some flaps had shrunk and 1 flap was found to have more mucous tissue than muscle. These pharyngeal flap deficits may have been due to rough flap handling during the surgical intervention. Therefore, gentle manipulation of such flaps during the course of surgery is emphasized. (author).

  13. CBP for Field Workers – Results and Insights from Three Usability and Interface Design Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Oxstrand, Johanna Helene [Idaho National Lab. (INL), Idaho Falls, ID (United States); Le Blanc, Katya Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bly, Aaron Douglas [Idaho National Lab. (INL), Idaho Falls, ID (United States); Medema, Heather Dawne [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, Wyatt Orcutt [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    Nearly all activities that involve human interaction with the systems in a nuclear power plant are guided by procedures. Even though the paper-based procedures (PBPs) currently used by industry have a demonstrated history of ensuring safety, improving procedure use could yield significant savings in increased efficiency as well as improved nuclear safety through human performance gains. The nuclear industry is constantly trying to find ways to decrease the human error rate, especially the human errors associated with procedure use. As a step toward the goal of improving procedure use and adherence, researchers in the Light-Water Reactor Sustainability (LWRS) Program, together with the nuclear industry, have been investigating the possibility and feasibility of replacing the current paper-based procedure process with a computer-based procedure (CBP) system. This report describes a field evaluation of new design concepts of a prototype computer-based procedure system.

  14. Evaluation of a New Needle Guidance System for Ultrasound: Results of a Prospective, Randomized, Blinded Study.

    Science.gov (United States)

    Swenson, Jeffrey D; Klingler, Kendell R; Pace, Nathan L; Davis, Jennifer J; Loose, Evelyn C

    2016-01-01

    Accurate needle control during ultrasound (US)-guided nerve blocks may be an elusive goal for the anesthesiologist. Despite modifications to increase echogenicity, needle visibility still requires precise alignment within the transducer beam. In this study, we evaluated a magnetically guided ultrasound (MGU) system that produces a real-time, graphic display of the needle position and trajectory that is independent of the US beam. The MGU system was compared with echogenic needles and conventional ultrasound (CU) by anesthesiologists with and without prior experience performing US-guided nerve blocks. Participants were asked to perform tasks to quantify accuracy with respect to needle direction (directional accuracy) and needle tip position (positional accuracy). These evaluations were performed in a porcine tissue model. Regarding directional accuracy, inexperienced subjects were able to contact a target capsule with a single needle pass during both in-plane (IP) and out-of-plane (OOP) approaches using the magnetic guidance system. By contrast, using CU, subjects required redirection 3.8 ± 2.4 (P = 0.02), and 4.5 ± 3.9 (P = 0.04) times, respectively, for IP and OOP approaches. Experienced subjects contacted the target capsule with a single pass for both IP and OOP approaches when using the magnetic guidance system. With CU, experienced subjects were able to contact the target with a single pass using an IP approach but required redirection 3.4 ± 2.8 (P = 0.046) times during OOP approaches. Positional accuracy was also superior for both inexperienced (P = 0.04) and experienced (P = 0.02) users during an OOP approach. In a tissue model, the MGU system improved control of needle trajectory and needle tip position for both inexperienced and experienced subjects.

  15. THE RESULTS OF TESTING TO EVALUATE CRYSTAL FORMATION AND SETTLING IN THE COLD CRUCIBLE INDUCTION MELTER

    Energy Technology Data Exchange (ETDEWEB)

    Marra, J.

    2009-06-30

    The Cold Crucible Induction Melter (CCIM) technology offers the potential to increase waste loading for High Level Waste (HLW) glasses leading to significant improvements in waste throughput rates compared to the reference Joule Heated Melter (JHM). Prior to implementation of a CCIM in a production facility it is necessary to better understand processing constraints associated with the CCIM. The glass liquidus temperature requirement for processing in the CCIM is an open issue. Testing was conducted to evaluate crystal formation and crystal settling during processing in the CCIM to gain insight into the effects on processing. A high aluminum/high iron content glass composition with known crystal formation tendencies was selected for testing. A continuous melter test was conducted for approximately 51 hours. To evaluate crystal formation, glass samples were obtained from pours and from glass receipt canisters where the glass melt had varying residence time in the melter. Additionally, upon conclusion of the testing, glass samples from the bottom of the melter were obtained to assess the degree of crystal settling. Glass samples were characterized in an attempt to determine quantitative fractions of crystals in the glass matrix. Crystal identity and relative composition were determined using a combination of x-ray diffraction (XRD) and scanning electron microscopy coupled with energy dispersive spectroscopy (SEM/EDS). Select samples were also analyzed by digesting the glass and determining the composition using inductively coupled atomic emission spectroscopy (ICP-AES). There was evidence of crystal formation (primarily spinels) in the melt and during cooling of the collected glass. There was evidence of crystal settling in the melt over the duration of the melter campaign.

  16. Early results on canine fetal kidney development: Ultrasonographic evaluation and value in prediction of delivery time.

    Science.gov (United States)

    Gil, Elaine Mayumi Ueno; Garcia, Daniela Aparecida Ayres; Giannico, Amália Turner; Froes, Tilde Rodrigues

    2017-11-16

    To date there have been no studies that describe the ultrasonographic evaluation of kidney development in canine fetuses. The aim of this prospective and longitudinal study was to monitor fetal kidney development with ultrasound and use fetal kidney measurements as a complementary biometric index for estimation of gestational age. Ultrasonographic examinations were performed on 15 clinically healthy pregnant bitches every four days from 30(th) day of pregnancy, until visualization of the fetal renal pelvis was no longer possible. Four distinct periods of ultrasonographic canine fetal kidney development were defined. Kidney length and renal pelvis distention were measured on longitudinal plane images. The fetal kidney ranged from 0.40 cm to 2.30 cm in length, and diameter of the pelvis ranged from 0.06 cm to 0.17 cm, however by the end of gestation the renal pelvis was no longer dilated and so its diameter could not be measured. Statistical analysis confirmed a relationship between gestational age and fetal kidney growth. Ultrasonographic evaluation of fetal kidney development is simple to perform. There is a strong correlation between gestational age and kidney length, which allowed generation of an equation to estimate delivery date with high sensitivity between 48 and 52 days of pregnancy. Fetal organ development can be considered complete when the renal pelvis is no longer dilated, this finding can assist the ultrasonographer in staging the gestation by prompting examination for fetal intestinal motility which begins at the same gestational age. Measurement of fetal kidney length can be used in conjunction with other methods to estimate gestational age and predict delivery time. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Update on scleral lenses.

    Science.gov (United States)

    Jacobs, Deborah S

    2008-07-01

    Scleral rigid gas-permeable lenses play an important and underappreciated role in the treatment of corneal disease. This review provides an update on scleral rigid gas-permeable lenses for the visual rehabilitation of ectasia and irregular astigmatism, and an update on scleral rigid gas-permeable lenses in the therapy of ocular surface disease. Several series and one case report present advances in the treatment of ocular surface disease with scleral rigid gas-permeable lenses. In addition, there are two reports describing one center's consecutive case experience using modern scleral lens design, predominantly in patients with ectasia and postkeratoplasty astigmatism. Finally, a comprehensive article reviewing the history and principles behind current scleral rigid gas-permeable lenses, with particular attention to the use of scleral rigid gas-permeable lenses in the management of ocular surface disorders was published. Clinicians who treat patients with ocular surface disease should be aware of scleral rigid gas-permeable lenses as a therapeutic option for their patients. Advances in lens design make scleral rigid gas-permeable lenses a practical option for an increasing number and variety of patients with corneal disease.

  18. EAU guidelines on renal cell carcinoma: 2014 update.

    Science.gov (United States)

    Ljungberg, Borje; Bensalah, Karim; Canfield, Steven; Dabestani, Saeed; Hofmann, Fabian; Hora, Milan; Kuczyk, Markus A; Lam, Thomas; Marconi, Lorenzo; Merseburger, Axel S; Mulders, Peter; Powles, Thomas; Staehler, Michael; Volpe, Alessandro; Bex, Axel

    2015-05-01

    The European Association of Urology Guideline Panel for Renal Cell Carcinoma (RCC) has prepared evidence-based guidelines and recommendations for RCC management. To provide an update of the 2010 RCC guideline based on a standardised methodology that is robust, transparent, reproducible, and reliable. For the 2014 update, the panel prioritised the following topics: percutaneous biopsy of renal masses, treatment of localised RCC (including surgical and nonsurgical management), lymph node dissection, management of venous thrombus, systemic therapy, and local treatment of metastases, for which evidence synthesis was undertaken based on systematic reviews adhering to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Relevant databases (Medline, Cochrane Library, trial registries, conference proceedings) were searched (January 2000 to November 2013) including randomised controlled trials (RCTs) and retrospective or controlled studies with a comparator arm. Risk of bias (RoB) assessment and qualitative and quantitative synthesis of the evidence were performed. The remaining sections of the document were updated following a structured literature assessment. All chapters of the RCC guideline were updated. For the various systematic reviews, the search identified a total of 10,862 articles. A total of 151 studies reporting on 78,792 patients were eligible for inclusion; where applicable, data from RCTs were included and meta-analyses were performed. For RCTs, there was low RoB across studies; however, clinical and methodological heterogeneity prevented data pooling for most studies. The majority of studies included were retrospective with matched or unmatched cohorts based on single or multi-institutional data or national registries. The exception was for systemic treatment of metastatic RCC, in which several RCTs have been performed, resulting in recommendations based on higher levels of evidence. The 2014 guideline has been updated by

  19. The use of the balanced scorecard in evaluating the results of the innovations implemented in metallurgical companies

    Directory of Open Access Journals (Sweden)

    L. Blacha

    2016-10-01

    Full Text Available Implementation of innovations is the main factor of development of companies’ competitiveness and effectiveness. Innovations result in creation of a value for both the client and the company. The article presents a method of evaluating the innovations implemented in industry which emphasises, on the background of qualitative changes, the measurable (quantitative effects of various types of innovations. For the purpose of measuring the results of implemented innovations the Balanced Scorecard was used. The method developed by the authors of the paper was used to evaluate results of the innovations implemented in metallurgical companies.

  20. Report of the European Society of Cardiology Cardiovascular Round Table regulatory workshop update of the evaluation of new agents for the treatment of acute coronary syndrome

    DEFF Research Database (Denmark)

    Bueno, Héctor; de Graeff, Pieter; Richard-Lordereau, Isabelle

    2016-01-01

    Regulatory authorities interpret the results of randomized controlled trials according to published principles. The European Medicines Agency (EMA) is planning a revision of the 2000 and 2003 guidance documents on clinical investigation of new medicinal products for the treatment of acute coronar...

  1. Impact of methodology on the results of economic evaluations of varicella vaccination programs: is it important for decision-making?

    Directory of Open Access Journals (Sweden)

    Patrícia Coelho de Soárez

    2009-01-01

    Full Text Available This study aims to review the literature on economic evaluation of childhood varicella vaccination programs and to discuss how heterogeneity in methodological aspects and estimation of parameters can affect the studies' results. After applying the inclusion criteria, 27 studies published from 1980 to 2008 were analyzed in relation to methodological differences. There was great heterogeneity in the perspective adopted, evaluation of indirect costs, type of model used, modeling of the effect on herpes zoster, and estimation of vaccine price and efficacy parameters. The factor with the greatest impact on results was the inclusion of indirect costs, followed by the perspective adopted and vaccine price. The choice of a particular methodological aspect or parameter affected the studies' results and conclusions. It is essential that authors present these choices transparently so that users of economic evaluations understand the implications of such choices and the direction in which the results of the analysis were conducted.

  2. Evaluation of observation-fused regional air quality model results for population air pollution exposure estimation.

    Science.gov (United States)

    Chen, Gang; Li, Jingyi; Ying, Qi; Sherman, Seth; Perkins, Neil; Sundaram, Rajeshwari; Mendola, Pauline

    2014-07-01

    In this study, Community Multiscale Air Quality (CMAQ) model was applied to predict ambient gaseous and particulate concentrations during 2001 to 2010 in 15 hospital referral regions (HRRs) using a 36-km horizontal resolution domain. An inverse distance weighting based method was applied to produce exposure estimates based on observation-fused regional pollutant concentration fields using the differences between observations and predictions at grid cells where air quality monitors were located. Although the raw CMAQ model is capable of producing satisfying results for O3 and PM2.5 based on EPA guidelines, using the observation data fusing technique to correct CMAQ predictions leads to significant improvement of model performance for all gaseous and particulate pollutants. Regional average concentrations were calculated using five different methods: 1) inverse distance weighting of observation data alone, 2) raw CMAQ results, 3) observation-fused CMAQ results, 4) population-averaged raw CMAQ results and 5) population-averaged fused CMAQ results. It shows that while O3 (as well as NOx) monitoring networks in the HRRs are dense enough to provide consistent regional average exposure estimation based on monitoring data alone, PM2.5 observation sites (as well as monitors for CO, SO2, PM10 and PM2.5 components) are usually sparse and the difference between the average concentrations estimated by the inverse distance interpolated observations, raw CMAQ and fused CMAQ results can be significantly different. Population-weighted average should be used to account for spatial variation in pollutant concentration and population density. Using raw CMAQ results or observations alone might lead to significant biases in health outcome analyses. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. HPV DNA Positivity Rate and Evaluation of Cytopatological Results in Patients with Chronic Vaginal Discharge

    Directory of Open Access Journals (Sweden)

    Güler Ateşer

    2014-06-01

    Full Text Available Aim: There are new publications stating that chronic infection may facilitate dysplastic changes and persistence of human papillomavirus (HPV-DNA positivity. Frequency of this coincidence and cervical cytological and pathological examination results were investigated in patients with chronic vaginal discharge. Methods: One hundred three patients, who were treated at least 3 times for chronic mucopurulent discharge with accessible HPV DNA results, were analyzed retrospectively. Risk factors were identified for HPV DNA positivity. HPV DNA positive-patients were divided into two groups (positive and negative according to the presence and absence of HPV DNA. The results of cytopatological and histopathological examinations and risk factors were compared between the two groups. Results: The mean age of the patients was 35±9 years. Sixty-four percent of the patients were positive for HPV DNA. Of the HPV DNA positive patients, 41% had abnormal cytological findings, 16% had cervical intraepithelial neoplasia (CIN. Of the HPV DNA-negative patients, 16% had abnormal cytological findings and, 2 patients had CIN. There was no statistically significant difference in cervical cytological abnormalities and CIN between HPV-DNA positive and negative groups. Conclusion: In our study, the rates of HPV DNA positivity and abnormal cytopathological results among patients with chronic vaginal discharge were found to be higher than that reported in the literature. (The Me­di­cal Bul­le­tin of Ha­se­ki 2014; 52: 93-7

  4. Response evaluation in nuclear medicine. Criteria, results and pitfalls; Nuklearmedizinische Responsebeurteilung. Kriterien, Ergebnisse und Pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Hoffend, J. [Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Onkologische Diagnostik/PET-CT, Zentralinstitut fuer diagnostische und interventionelle Radiologie, Ludwigshafen (Germany); Sachpekidis, C. [Deutsches Krebsforschungszentrum Heidelberg, Klinische Kooperationseinheit Nuklearmedizin, Forschungsschwerpunkt Bildgebung und Radiologie, Heidelberg (Germany); Deutsches Krebsforschungszentrum Heidelberg, Abteilung Radiologie, Forschungsschwerpunkt Bildgebung und Radiologie, Heidelberg (Germany); Dimitrakopoulou-Strauss, A. [Deutsches Krebsforschungszentrum Heidelberg, Klinische Kooperationseinheit Nuklearmedizin, Forschungsschwerpunkt Bildgebung und Radiologie, Heidelberg (Germany)

    2017-10-15

    Established criteria to categorize metabolic tumor response to cytotoxic chemotherapies may not be suited to capture the effects of therapy with immune checkpoint inhibitors (ICI) or with kinase inhibitors (KI), such as BRAF or MEK inhibitors. To assess the metabolic response to cytotoxic chemotherapy by positron emission tomography (PET) with {sup 18}F-fluorodeoxyglucose (FDG), the criteria of the European Organization for Research and Treatment of Cancer (EORTC) and the positron emission tomography response criteria in solid tumors (PERCIST) were conceived. The salient features of both criteria are detailed in a comparative way. To date only retrospective data exist for the evaluation of therapies with either ICI or KI. They show that response to ICI cannot be reliably determined using the established criteria. Employing the EORTC criteria the responses to KI can be adequately ascertained so that the metabolic tumor response in FDG-PET is regarded as a surrogate marker for the efficacy of these drugs. Tumor response to therapy with ICI cannot at present be assessed with FDG-PET. Responses to BRAF and MEK inhibitors are, however, assessable using the criteria that were originally developed to evaluate responses to cytotoxic chemotherapy. (orig.) [German] Bisherige Kriterien, welche das metabolische Ansprechen von Tumoren auf zytotoxische Chemotherapien klassifizieren, lassen sich moeglicherweise nur bedingt verwenden, um ein Ansprechen auf Immuncheckpointinhibitoren (ICI) und Kinasehemmer (KI) wie BRAF- und MEK-Inhibitoren zu erfassen. Um das Ansprechen unter Chemotherapie durch die Positronenemissionstomographie (PET) mit {sup 18}F-Fluordesoxyglukose (FDG) zu erfassen, wurden Kriterien der European Organization for Research and Treatment of Cancer (EORTC) und die Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) entwickelt. Die wesentlichen Merkmale beider Kriterien werden vergleichend beschrieben. Bisher liegen sowohl fuer ICI als auch KI

  5. Evaluation of proximal caries in images resulting from different modes of radiographic digitalization.

    Science.gov (United States)

    Xavier, C R G; Araujo-Pires, Ana Claudia; Poleti, M L; Rubira-Bullen, I R F; Ferreira, O; Capelozza, A L A

    2011-09-01

    The aim of this study was to evaluate the performances of observers in diagnosing proximal caries in digital images obtained from digital bitewing radiographs using two scanners and four digital cameras in Joint Photographic Experts Group (JPEG) and tagged image file format (TIFF) files, and comparing them with the original conventional radiographs. In total, 56 extracted teeth were radiographed with Kodak Insight film (Eastman Kodak, Rochester, NY) in a Kaycor Yoshida X-ray device (Kaycor X-707; Yoshida Dental Manufacturing Co., Tokyo, Japan) operating at 70 kV and 7 mA with an exposure time of 0.40 s. The radiographs were obtained and scanned by CanonScan D646U (Canon USA Inc., Newport News, VA) and Genius ColorPage HR7X (KYE Systems Corp. America, Doral, FL) scanners, and by Canon Powershot G2 (Canon USA Inc.), Canon RebelXT (Canon USA Inc.), Nikon Coolpix 8700 (Nikon Inc., Melville, NY), and Nikon D70s (Nikon Inc.) digital cameras in JPEG and TIFF formats. Three observers evaluated the images. The teeth were then observed under the microscope in polarized light for the verification of the presence and depth of the carious lesions. The probability of no diagnosis ranged from 1.34% (Insight film) to 52.83% (CanonScan/JPEG). The sensitivity ranged from 0.24 (Canon RebelXT/JPEG) to 0.53 (Insight film), the specificity ranged from 0.93 (Nikon Coolpix/JPEG, Canon Powershot/TIFF, Canon RebelXT/JPEG and TIFF) to 0.97 (CanonScan/TIFF and JPEG) and the accuracy ranged from 0.82 (Canon RebelXT/JPEG) to 0.91 (CanonScan/JPEG). The carious lesion diagnosis did not change in either of the file formats (JPEG and TIFF) in which the images were saved for any of the equipment used. Only the CanonScan scanner did not have adequate performance in radiography digitalization for caries diagnosis and it is not recommended for this purpose.

  6. Update on multidetector coronary CT angiography of coronary stents: in vitro evaluation of 29 different stent types with dual-source CT

    Energy Technology Data Exchange (ETDEWEB)

    Maintz, David; Burg, Matthias C.; Seifarth, Harald; Bunck, Alexander C.; Oezguen, Murat; Juergens, Kai Uwe; Heindel, Walter [University of Muenster, Department of Clinical Radiology, Muenster (Germany); Fischbach, Roman [University of Muenster, Department of Clinical Radiology, Muenster (Germany); Asklepios Klinikum Altona, Department of Radiology and Nuclear Medicine, Hamburg (Germany)

    2009-01-15

    The aim of this study was to test a large sample of the latest coronary artery stents using four image reconstruction approaches with respect to lumen visualization, lumen attenuation, and image noise in dual-source multidetector row CT (DSCT) in vitro and to provide a CT catalogue of currently used coronary artery stents. Twenty-nine different coronary artery stents (19 steel, 6 cobalt-chromium, 2 tantalum, 1 iron, 1 magnesium) were examined in a coronary artery phantom (vessel diameter 3 mm, intravascular attenuation 250 HU, extravascular density -70 HU). Stents were imaged in axial orientation with standard parameters: 32 x 0.6 collimation, pitch 0.24, 400 mAs, 120 kV, rotation time 0.33 s. Image reconstructions were obtained with four different convolution kernels (soft, medium-soft, standard high-resolution, stent-dedicated). To evaluate visualization characteristics of the stent, the lumen diameter, intraluminal density, and noise were measured. The stent-dedicated kernel offered best average lumen visualization (54{+-}8.3%) and most realistic lumen attenuation (222{+-}44 HU) at the expense of increased noise (23.9{+-}1.9 HU) compared with standard CTA protocols (p<0.001 for all). The magnesium stent showed the least artifacts with a lumen visibility of 90%. The majority of stents (79%) exhibited a lumen visibility of 50-59%. Less than half of the stent lumen was visible in only six stents. Stent lumen visibility largely varies depending on the stent type. Magnesium is by far more favorable a stent material with regard to CT imaging when compared with the more common materials steel, cobalt-chromium, or tantalum. The magnesium stent exhibits a lumen visibility of 90%, whereas the majority of the other stents exhibit a lumen visibility of 50-59%. (orig.)

  7. Evaluation of patients with oral lichenoid lesions by dental patch testing and results of removal of the dental restoration material

    OpenAIRE

    Emine Buket Şahin; Fatma Çetinözman; Nihal Avcu; Ayşen Karaduman

    2016-01-01

    Background and Design: Oral lichenoid lesions (OLL) are contact stomatitis characterized by white reticular or erosive patches, plaque-like lesions that are clinically and histopathologically indistinguishable from oral lichen planus (OLP). Amalgam dental fillings and dental restoration materials are among the etiologic agents. In the present study, it was aimed to evaluate the standard and dental series patch tests in patients with OLL in comparison to a control group and evaluate our result...

  8. Evaluation on Degree and Result of Bilingual Education of Business Courses in GDUFS

    Science.gov (United States)

    Jiang, Yong

    2013-01-01

    From the connotation of bilingual education in higher education in China, this paper analyzes the factors that may affect the quality and result of bilingual education, such as faculty and students' English level, teaching materials, curriculum system, classroom instruction, teaching quality control, as well as incentives and other factors. The…

  9. An evaluation of algorithms designed to classify the results from frequency doubling perimetry

    NARCIS (Netherlands)

    Muskens, RPHM; Heeg, GP; Jansonius, NM

    2004-01-01

    All previously published algorithms for the interpretation of frequency doubling perimetry test results were compared in full-threshold mode in a large group of glaucoma patients (n = 452) and normal subjects (n = 237). Areas under the receiver-operating characteristic (ROC) curve ranged from 0.86

  10. Employee Post-Training Behaviour and Performance: Evaluating the Results of the Training Process

    Science.gov (United States)

    Diamantidis, Anastasios D.; Chatzoglou, Prodromos D.

    2014-01-01

    Despite the fact that firms invest in training, there is considerable evidence to show that training programmes often fail to achieve the intended result of improving worker and organization performance. The purpose of this paper is to examine the medium- to long-term effects of training programmes on firms by means of an integrated research model…

  11. Experimental Evaluation of Relationships among Populations Resulting from Intergradation among Cultivars of ZEA MAYS L.

    Science.gov (United States)

    Hanson, W D; Moll, R H

    1973-05-01

    Populations were developed as intergradations among three maize cultivars, two adapted to North Carolina and one to Mexico, with the objective of testing whether diallel information could be used to identify the relationships among populations. The data substantiated theoretical observations that the technique would identify relationships among populations resulting from recent intergradations.

  12. Results-Based Monitoring and Evaluation at the Commonwealth of Learning: A Handbook

    Science.gov (United States)

    Farrell, Glen M.

    2009-01-01

    Results-based management (RBM) is an approach to programme planning and management that integrates strategy, people, resources, processes and measurements to improve decision-making, transparency and accountability. The Commonwealth of Learning (COL) began the adoption of a RBM model with its 2003-2006 Three-Year Plan. This led to a significantly…

  13. Evaluation of the results of operative treatment of hip dysplasia in ...

    African Journals Online (AJOL)

    Methods: The study included 35 patients (42 hips), they had been treated by different combinations of open reduction, femoral (shortening, derotation and varus) and pelvic (Salter or Dega) osteotomy. The age at the time of the operation ranged from 18 to 96 months. Results: At the end of follow-up (a mean of 33.5 months), ...

  14. EVALUATION OF RESULTS IN CHOSEN SUBJECTS AND ANALYSIS OF THE MOTIVATION OF ADULT STUDENTS

    Directory of Open Access Journals (Sweden)

    VOSTRÁ VYDROVÁ, Hana

    2012-03-01

    Full Text Available The university studies of adult people in the combined or distance form of study denotes many differences in comparison with the regular studies. Very important question is if the results of the distance students are on the same level as those of regular students. The Czech University of Life Sciences in Prague has steadily high number of combined students in tutorial centres outside Prague. The contribution is based on an inquiry survey among the students of tutorial centres. Another data source is the official database of the university. The level of satisfaction of students was compared with their results and a negative dependency was found. We also investigated the relation between socio demographic characteristics and the motivation and attitude to the study. We found dependencies in three questions. Finally, we compare the results of the students from the tutorial centers and regular students and have not found remarkable differences. The good (not worse results of students from the centers of distance studies can be explained by more intensive motivation which implies more intensive and more responsible preparation for exams. For the statistical analysis we used the software SPSS, version 18.

  15. A New Sparse Quasi-Newton Update Method

    Directory of Open Access Journals (Sweden)

    Minghou Cheng

    2012-04-01

    Full Text Available Based on the idea of maximum determinant positive definite matrix completion, Yamashita proposed a sparse quasi-Newton update, called MCQN, for unconstrained optimization problems with sparse Hessian structures. Such an MCQN update keeps the sparsity structure of the Hessian while relaxing the secant condition. In this paper, we propose an alternative to the MCQN update, in which the quasi-Newton matrix satisfies the secant condition, but does not have the same sparsity structure as the Hessian in general. Our numerical results demonstrate the usefulness of the new MCQN update with the BFGS formula for a collection of test problems. A local and superlinear convergence analysis is also provided for the new MCQN update with the DFP formula.

  16. Economic evaluation of the Annual Cycle Energy System (ACES). Volume II. Detailed results. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    The energy effectiveness and the economic viability of the ACES concept are examined. ACES is studied in a variety of different applications and compared to a number of conventional systems. The different applications are studied in two groups: the class of building into which the ACES is incorporated and the climatic region in which the ACES is located. Buildings investigated include single-family and multi-family residences and a commercial office building. The application of ACES to each of these building types is studied in Minneapolis, Atlanta, and Philadelphia. The economic evaluation of the ACES is based on a comparison of the present worth of the ACES to the present worth of conventional systems; namely, electric resistance heating, electric air conditioning, and electric domestic water heating; air-to-air heat pump and electric domestic water heating; oil-fired furnace, electric air conditioning, and electric domestic water heating; and gas-fired furnace, electric air conditioning, and gas domestic water heating.

  17. Pilot evaluation of a media literacy program for tobacco prevention targeting early adolescents shows mixed results.

    Science.gov (United States)

    Kaestle, Christine E; Chen, Yvonnes; Estabrooks, Paul A; Zoellner, Jamie; Bigby, Brandon

    2013-01-01

    The purpose of this pilot study was to assess the impact of media literacy for tobacco prevention for youth delivered through a community site. A randomized pretest-posttest evaluation design with matched-contact treatment and control conditions. The pilot study was delivered through the YMCA in a lower-income suburban and rural area of Southwest Virginia, a region long tied, both economically and culturally, to the tobacco industry. Children ages 8 to 14 (76% white, 58% female) participated in the study (n = 38). The intervention was an antismoking media literacy program (five 1-hour lessons) compared with a matched-contact creative writing control program. General media literacy, three domains of tobacco-specific media literacy ("authors and audiences," "messages and meanings," and "representation and reality"), tobacco attitudes, and future expectations were assessed. Multiple regression modeling assessed the impact of the intervention, controlling for pretest measures, age, and sex. General media literacy and tobacco-specific "authors and audiences" media literacy improved significantly for treatment compared with control (p literacy measures and for tobacco attitudes were not significant. Future expectations of smoking increased significantly for treatment participants ages 10 and younger (p literacy are accompanied by an increase in future expectations to smoke for younger children.

  18. A prospective evaluation of zirconia anterior partial fixed dental prostheses: Clinical results after seven years.

    Science.gov (United States)

    Solá-Ruíz, Maria Fernanda; Agustin-Panadero, Rubén; Fons-Font, Antonio; Labaig-Rueda, Carlos

    2015-06-01

    Because of the high mechanical strength of zirconium dioxide, the metal in fixed partial prostheses can now be replaced. However, the material is susceptible to aging or hydrothermal degradation and to chipping of the feldspathic veneer. The purpose of this prospective study was to evaluate the survival (without failure) and success (survival without any complication or failure) rate and clinical efficacy of anterior zirconia partial fixed dental prostheses. Twenty-seven anterior partial fixed dental prostheses of 3 to 6 units were fabricated. All participants were examined after 1 month and 6 months, then annually for 7 years. Three partial fixed dental prostheses failed and had to be removed: 2 because of secondary caries, which increased failure significantly (P=.001) and 1 because of severe chipping. Six partial fixed dental prostheses had complications: 2 debonded, 3 had chipping, and 1 had periapical pathology. All veneer porcelain fractures occurred in 6-unit fixed partial prostheses (P=.002). The clinical success rate was 88.8% after the 7-year follow-up. The clinical behavior of partial fixed dental prostheses with a zirconium dioxide core in the anterior region provides an adequate medium-term survival rate. The main cause of failure was secondary caries. The most frequent complication was chipping, which was directly related to the number of units of the prosthesis. Copyright © 2015 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  19. Evaluation of Class I ART restorations in Brazilian schoolchildren: three-year results.

    Science.gov (United States)

    Wang, Linda; Lopes, Lawrence Gonzaga; Bresciani, Eduardo; Lauris, José Roberto Pereira; Mondelli, Rafael Francisco Lia; Navarro, Maria Fidela de Lima

    2004-01-01

    Atraumatic Restorative Treatment (ART) has been adopted around the world to avoid unnecessary extractions, especially in non-industrialized countries. The development of specific glass ionomer cements marketed for the ART technique has contributed to the technical success rate. In this study, Ketac-Molar (3M ESPE, Dental Medzin, Germany) was used to restore 150 Class I cavities in 118 Brazilian public school children, aged from 7-12 years. At baseline and at subsequent recalls, CPI probes with a ball-end of 0.5 millimeters (mm) were used to assess loss of restorative material, and photographic color transparencies of restorations were made. After six months, 83 patients returned for follow-up examinations, with 71.8% of their restorations designated as acceptable. After three years, 49 patients with 57 ART-restorations were evaluated, with 21.0% of these restorations graded as acceptable. Another 29.8% of their restorations had been replaced by more permanent materials. The main objective of the ART technique is tooth retention; this was achieved for 94.7% of the restored teeth in a high caries risk population who returned for recalls.

  20. An evaluation of selected NASA scientific and technical information products: Results of a pilot study

    Science.gov (United States)

    Pinelli, Thomas E.; Glassman, Myron

    1989-01-01

    A pilot study was conducted to evaluate selected NASA scientific and technical information (STI) products. The study, which utilized survey research in the form of a self-administered mail questionnaire, had a two-fold purpose -- to gather baseline data regarding the use and perceived usefulness of selected NASA STI products and to develop/validate questions that could be used in a future study concerned with the role of the U.S. government technical report in aeronautics. The sample frame consisted of 25,000 members of the American Institute of Aeronautics and Astronautics in the U.S. with academic, government or industrial affiliation. Simple random sampling was used to select 2000 individuals to participate in the study. Three hundred fifty-three usable questionnaires (17 percent response rate) were received by the established cutoff date. The findings indicate that: (1) NASA STI is used and is generally perceived as being important; (2) the use rate for NASA-authored conference/meeting papers, journal articles, and technical reports is fairly uniform; (3) a considerable number of respondents are unfamiliar with STAR (Scientific and Technical Aerospace Reports), IAA (International Aerospace Abstracts), SCAN (Selected Current Aerospace Notices), and the RECON on-line retrieval system; (4) a considerable number of respondents who are familiar with these media do not use them; and (5) the perceived quality of NASA-authored journal articles and technical reports is very good.

  1. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey.

    Science.gov (United States)

    Sivanandy, Palanisamy; Maharajan, Mari Kannan; Rajiah, Kingston; Wei, Tan Tyng; Loon, Tan Wee; Yee, Lim Chong

    2016-01-01

    Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use. To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia. A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted. The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of "staff training and skills" were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup. The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety.

  2. Drugs in resuscitation: an update.

    Science.gov (United States)

    Lee, S W

    2011-08-01

    Drug therapy is recommended after effective cardiopulmonary resuscitation and defibrillation in cardiac arrest. Some drugs appear to have short-term benefits, such as improved survival to hospital, e.g. vasopressor and antiarrhythmics. Hence, they have been included in the cardiac life support algorithm. However, to date, no drug (or combination of drugs) has been shown to improve long-term survival in randomised trials. Hopefully, improvements in post-arrest intensive unit care can translate improved survival in hospitals into better long-term outcomes. This review is an update on drugs during resuscitation, including the choice of agents, dosing, sequence and route. Specific drugs may have benefits in correcting identified causes of collapse. Drug usage during resuscitation is an evolving science, with the use of medications improving as results of clinical studies become available.

  3. Methodological update in Medicina Intensiva.

    Science.gov (United States)

    García Garmendia, J L

    2018-02-06

    Research in the critically ill is complex by the heterogeneity of patients, the difficulties to achieve representative sample sizes and the number of variables simultaneously involved. However, the quantity and quality of records is high as well as the relevance of the variables used, such as survival. The methodological tools have evolved to offering new perspectives and analysis models that allow extracting relevant information from the data that accompanies the critically ill patient. The need for training in methodology and interpretation of results is an important challenge for the intensivists who wish to be updated on the research developments and clinical advances in Intensive Medicine. Copyright © 2018 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  4. RAMIS DBMS Update

    Science.gov (United States)

    Head, J.

    1984-01-01

    Highlights of a round table discussion of end-user computing, IBM strategies, fourth generation languages, and directions for software innovation are presented as well as observations from an in-depth study of 271 organizations. The RAMIS data base management system is evaluated according to 10 defining criteria for a fourth-generation language: result-oriented programming; common language/demand level adaptability; application extension; user/machine insulation; work station environment; comprehensive software toolkit; integrating perspective on computing and data resources; end user data base capability; accessible dictionaries; and user assistance/facility coordination.

  5. [Superselective vagotomy of parietal cells. Evaluation and results in duodenal ulcer].

    Science.gov (United States)

    Diez, A; Ortega, J A; Rodríguez, F; Quiróz, D; Ruiz, C; Sorgi, M

    1977-01-01

    The authors present a study carried out jointly by the Gastroenterology Service and Surgical Service No. 2 of the General Hospital of the Venezuela Institute of Social Security "Dr. Ildemaro Salas". The results and objectives of the operation are analyzed insisting on its lower morbility and mortality, as well as on the lower incidence of diarrhea, dumping and other gastrointestinales discomforts. The first operation was performed on 17 november 1971 and up to the present 74 patients have been operated, 65 for duodenal ulcers, 7 for esophageal hernia of the hiatus, 1 case of hemorrhagic gastritis, and 1 case of prepyloric ulcer. Some details are given of the operations, the indications for it are pointed out, specially gastric hyperacidity, symptomatic ulcer, and absence of duodenal stenosis. There were 7 post-operative complications and 2 cases of mortality. As to the results there are presented 92% successful interventions and 8% failures.

  6. [The results of the pharmacological treatment of attention deficit hyperactivity disorder: evaluation with neuropsychological methods].

    Science.gov (United States)

    Zavadenko, N N; Suvorinova, N Iu

    2014-01-01

    To investigate the dynamics of behavioral indicators, attention and memory in children with attention deficit hyperactivity disorder (ADHD) treated with noofen (capsules 250 mg). In an open study, 50 patients were randomized to 2 equal groups: patients of group 1 were treated with noofen (15-20 mg/kg (500-700 mg) per day perorally in 2-3 doses); the control group received low doses of multivitamins. Duration of treatment was one month. The results of neuropsychological testing revealed the improvement of cognitive functions, including the indicators of self-control, sustained, directed and divided attention, acoustic-verbal memory, to the end of treatment. The initial positive changes may be the basis for obtaining better clinical results during long-term treatment.

  7. [Results of serial CT in the evaluation of the sellar region].

    Science.gov (United States)

    Fink, U; Mayr, B; Markl, A; Baumer, K; von Werder, K; Lissner, J

    1983-12-01

    The article reports on the methodology and results of serial CT in differential diagnosis of intrasellar and parasellar structures, based on 32 examinations. Whereas the normal pituitary gland displays an approximately equal contrast medium performance as the pituitary adenomas and recurrent tumours, different types of tissue such as those of tumours, vascular structures and postoperative scans can be well differentiated from each other by means of serial CT. Aneurysms can be safely differentiated from intracranial tumours, such as meningiomas, only via serial CT.

  8. Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Lech Chyczewski

    2010-08-01

    Full Text Available The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.

  9. EVALUATION OF RESULTS OF ROAD RESEARCH OF LANOS CAR, EQUIPPED WITH AN ADVANCED HYDRAULIC BRAKE DRIVE

    Directory of Open Access Journals (Sweden)

    I. Nazarov

    2016-12-01

    Full Text Available The results of studies of road emergency braking of the car, the brake system equipped with an improved hydraulic brake actuator according to the patent number 76189 Ukraine are analyzed. This drive provides more efficient emergency braking of cars under operating conditions by of installing in each of the contours of the rear brakes one brake-power, each of which provides distribution of braking forces between the wheels of the corresponding side.

  10. Evaluation of hemoglobinopathy screening results of a six year period in Turkey '

    OpenAIRE

    Seçil Gunher Arıca; Ebru Turhan; Cahit Özer; Vefik Arıca; Dilek Benk Şilfeler; İbrahim Şilfeler; Ayşe Betül Altun

    2012-01-01

    Background and Objectives: Hemoglobinopathies are autosomal recessive inherited diseases more commonly seen in Mediterranean countries. Hereditary blood diseases including B-thalassemia and sickle cell anemia are important health problems. In our study we aimed to analyze the results of the premarital hemoglobinopathy screening test for a 6 years period in Hatay region. Material and Methods: The study sample comprised the couples attending to the Mother and Child Health Care Center in Hatay ...

  11. Brain spect in the pre-surgical evaluation of epileptic patients preliminary results

    Directory of Open Access Journals (Sweden)

    Carlos A. Buchpiguel

    1992-03-01

    Full Text Available Pre-surgical evaluation of epileptic patients consists of neurological examination, intensive electroencephalographic (EEG monitoring and anatomical studies (CT and MRI. Functional methods such as PET and SPECT imaging are now used more frequently. We have studied pre-operatively 15 adult epileptic patients (8 female, 7 male using a rotational scintillation camera interfaced to a dedicated computer. The tomographic images were obtained 15 minutes after intravenous injection of 99mTc_HMPAO. All had MRI scanning and intensive EEG monitoring which generally included seizure recording. Five patients had progressive lesions (3 meningiomas, 2 astrocytomas. In 10 patients, neuroradiological studies did not show the presence of progressive lesions (2 normal scans and 8 cases with inactive lesions. Two patients with meningioma showed hypoperfusion at the lesion site while the third patient had a marked hyperperfusion which might correlate with the clinical diagnosis of epilepsia partialis continua. In the astrocytoma patients SPECT scans showed hypoperfusion at the lesion site. Data obtained from the 10 patients without progressive CNS lesions showed: (a in 4, SPECT findings correlated well with the anatomical findings; (b in 5 instances, SPECT was able to disclose additional functional deficits; (c in one case, there was no SPECT correlate of a discrete anatomical lesion. In 5 of these cases with no progressive lesions (n=10 SPECT findings were useful as a complementary tool in determining the clinical or surgical management of these patients. Despite the small number and hete-rogenicity of the present sample, SPECT seems to be an useful tool as part of the clinical workup of epileptic patients who are candidates for epilepsy surgery.

  12. The heart truth professional education campaign on women and heart disease: needs assessment and evaluation results.

    Science.gov (United States)

    Pregler, Janet; Freund, Karen M; Kleinman, Mary; Phipps, Maureen G; Fife, Rose S; Gams, Becky; Núñez, Ana E; Seaver, Margaret R; Lazarus, Cathy J; Raymond, Nancy C; Briller, Joan; Uijtdehaage, Sebastian; Moskovic, Cindy S; Guiton, Gretchen; David, Michele; Gabeau, Geralde V; Geller, Stacie; Meekma, Kelli; Moore, Christopher; Robertson, Candace; Sarto, Gloria

    2009-10-01

    Heart disease is the leading cause of death for women in the United States. Research has identified that women are less likely than men to receive medical interventions for the prevention and treatment of heart disease. As part of a campaign to educate healthcare professionals, 1245 healthcare professionals in 11 states attended a structured 1-hour continuing medical education (CME) program based on the 2004 AHA Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women and completed a pretest and posttest evaluation. We identified significant knowledge deficits in the pretest: 45% of attendees would initially recommend lifestyle changes alone, rather than statin therapy, for women diagnosed with coronary artery disease (CAD); 38% identified statin therapy as less effective in women compared with men for preventing CAD events; 27% identified Asian American women at low risk (rather than high risk) for type 2 diabetes mellitus (DM); and 21% identified processed meat (rather than baked goods) as the principal dietary source of trans fatty acids. Overall, healthcare professionals answered 5.1 of 8 knowledge questions correctly in the pretest, improving to 6.8 questions in the posttest (p < 0.001). Family physicians, obstetrician/gynecologists, general internists, nurse practitioners/physician assistants, and registered nurses all statistically significantly improved knowledge and self-assessed skills and attitudes as measured by the posttest. Significant knowledge deficits are apparent in a cross-section of healthcare providers attending a CME lecture on women and heart disease. A 1-hour presentation was successful in improving knowledge and self-assessed skills and attitudes among primary care physicians, nurse practitioners, physician assistants, and registered nurses.

  13. NASA Stratospheric Observatory For Infrared Astronomy (SOFIA) Airborne Astronomy Ambassador Program Evaluation Results To Date

    Science.gov (United States)

    Harman, Pamela K.; Backman, Dana E.; Clark, Coral

    2015-08-01

    SOFIA is an airborne observatory, capable of making observations that are impossible for even the largest and highest ground-based telescopes, and inspires instrumention development.SOFIA is an 80% - 20% partnership of NASA and the German Aerospace Center (DLR), consisting of a modified Boeing 747SP aircraft carrying a diameter of 2.5 meters (100 inches) reflecting telescope. The SOFIA aircraft is based at NASA Armstrong Flight Research Center, Building 703, in Palmdale, California. The Science Program Office and Outreach Office is located at NASA Ames Research center. SOFIA is one of the programs in NASA's Science Mission Directorate, Astrophysics Division.SOFIA will be used to study many different kinds of astronomical objects and phenomena, including star birth and death, formation of new solar systems, identification of complex molecules in space, planets, comets and asteroids in our solar system, nebulae and dust in galaxies, and ecosystems of galaxies.Airborne Astronomy Ambassador Program:The SOFIA Education and Communications program exploits the unique attributes of airborne astronomy to contribute to national goals for the reform of science, technology, engineering, and math (STEM) education, and to the elevation of public scientific and technical literacy.SOFIA’s Airborne Astronomy Ambassadors (AAA) effort is a professional development program aspiring to improve teaching, inspire students, and inform the community. To date, 55 educators from 21 states; in three cohorts, Cycles 0, 1 and 2; have completed their astronomy professional development and their SOFIA science flight experience. Cycle 3 cohort of 28 educators will be completing their flight experience this fall. Evaluation has confirmed the program’s positive impact on the teacher participants, on their students, and in their communities. Teachers have incorporated content knowledge and specific components of their experience into their curricula, and have given hundreds of presentations and

  14. Can an Infusion of Federal Funds Result in Sustainable Projects? An Evaluation of Suicide Prevention Programs.

    Science.gov (United States)

    Apsler, Robert; Formica, Scott W; Stout, Ellyson; Carr, Colleen

    2017-12-01

    Our study evaluated the sustainability of programs in early cohorts of the Garrett Lee Smith (GLS) Memorial Act suicide prevention initiative, a major source of federal funding for youth suicide prevention among states, tribes, and institutions of higher education. We sought to: (1) determine whether suicide prevention activities initiated with federal support continued after funding ended, and (2) identify factors associated with sustainment. Thirty-three sites between 1 and 4 years beyond the end of their GLS grant participated in a retrospective online survey assessing their level of suicide prevention activity 1 year before, during (during-GLS), and 1 year after funding (after-GLS). We found that, on average, sites experienced a 6% decrease in their overall level of activity from during- to after-GLS. Twenty-two (67% of responding sites) exhibited either an increase in activity level or no more than a 10% decline from during- to after-GLS periods. After-GLS scores for the 11 remaining sites declined between 11 and 30% from their during-GLS levels. We conducted semi-structured follow-up interviews with 13 sites that successfully continued their activities to explore factors associated with sustainability. Our findings indicate that program actions in the during-GLS period associated with sustainability included: maintaining a sustainability mindset, developing and nurturing partnerships and relationships, embedding services in parent organizations, pursuing new and diversified funding, and implementing cost-reduction efficiencies. Actions in the after-GLS period associated with sustainability included: obtaining funding from other sources, reconfiguring, and maintaining continuous leadership.

  15. Forensic medical evaluation of deaths resulting from inhalation of cigarette lighter refill fuel in Turkey.

    Science.gov (United States)

    Özdemir, Erdinç; Eş, Hüseyin; Demir, Muhammet; Üzün, İbrahim

    2017-01-01

    Voluntary inhalation/abuse of volatile substances is an important public health problem which especially affects adolescent and young populations worldwide and may be encountered in all socioeconomic and cultural levels. Lighter gas abuse-related death is still an important health problem in Turkey. In this study, 25,265 case files and final reports submitted to the Institute of Forensic Medicine of the First Specialization Board between January 2011 and December 2015 were evaluated retrospectively. In 56 of these cases, lighter gas inhalation (n-butane, propane, isobutane) was recorded as the cause of death. All subjects were male with a mean age of 16.8years. According to eyewitness and crime scene investigation reports, in 48 (85.7%) of the cases, a lighter refill container was found at the scene. It was determined that 21.4% of the cases used a plastic bag to increase the effects of lighter gas and 76.8% inhaled the lighter gas via their mouth and nose. The toxicological analysis of the samples taken while hospitalized showed no lighter refill components (n-butane, propane, isobutane) in 66% of the cases, n-butane in 32.1% of the cases, and n-butane+propane+isobutane in 1.9% of the cases. The importance of lighter gas inhalation-related deaths in Turkey has been increasing. Strict measures against the abuse of these very dangerous substances should be undertaken by the mutual efforts of medical specialists and legislators. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Method for evaluating prediction models that apply the results of randomized trials to individual patients

    Directory of Open Access Journals (Sweden)

    Kattan Michael W

    2007-06-01

    Full Text Available Abstract Introduction The clinical significance of a treatment effect demonstrated in a randomized trial is typically assessed by reference to differences in event rates at the group level. An alternative is to make individualized predictions for each patient based on a prediction model. This approach is growing in popularity, particularly for cancer. Despite its intuitive advantages, it remains plausible that some prediction models may do more harm than good. Here we present a novel method for determining whether predictions from a model should be used to apply the results of a randomized trial to individual patients, as opposed to using group level results. Methods We propose applying the prediction model to a data set from a randomized trial and examining the results of patients for whom the treatment arm recommended by a prediction model is congruent with allocation. These results are compared with the strategy of treating all patients through use of a net benefit function that incorporates both the number of patients treated and the outcome. We examined models developed using data sets regarding adjuvant chemotherapy for colorectal cancer and Dutasteride for benign prostatic hypertrophy. Results For adjuvant chemotherapy, we found that patients who would opt for chemotherapy even for small risk reductions, and, conversely, those who would require a very large risk reduction, would on average be harmed by using a prediction model; those with intermediate preferences would on average benefit by allowing such information to help their decision making. Use of prediction could, at worst, lead to the equivalent of an additional death or recurrence per 143 patients; at best it could lead to the equivalent of a reduction in the number of treatments of 25% without an increase in event rates. In the Dutasteride case, where the average benefit of treatment is more modest, there is a small benefit of prediction modelling, equivalent to a reduction of

  17. Updates Technologies of Media Change

    Science.gov (United States)

    Comer, Joshua

    2015-01-01

    Whether as status notifications in news feeds or interactive prompts in online video services, updates punctuate the background routines of media by bringing a variety of changes to the attention of users. In this dissertation I argue that updates rationalize media change by making previously obscure actions of users and movements of technologies…

  18. Episodic fieldwork, updating, and sociability

    DEFF Research Database (Denmark)

    Whyte, M.

    2013-01-01

    on these relationships. I draw on Simmel's concept of sociability to explore the significance of the recurring updates that are so much a part of long-term and thus episodic fieldwork. Updating suggests participation, positionality, and transformation-as well as play and familiarity. The presumption of familiarity...

  19. Demonstration project Klaipeda, Lithuania. Final evaluation of 2. year results after rehabilitation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-08-01

    In order to investigate various options for reducing the district heating return temperature and for introducing energy saving measures in the buildings in Klaipeda, a demonstration area comprising eight buildings was selected. The eight buildings selected were typical 5-floor buildings built in 1982-89. This enabled the experience from the project to be transferred to a maximum number of buildings in Klaipeda and in Lithuania, in general. The existing heating system in all the buildings consisted of a hydro-elevator system and a one-string radiator system. The hot tap water preparation was a tube heat exchanger and a circulation pipe including towel dryers. Since 1991, the supply temperature in the Klaipeda district heating system has been reduced due to shortage of fuel. This has led to a lower indoor temperature, which has decreased from the design value 18 deg. C to 15 deg. C in 1997 and 1998. In 1999, the supply temperature was, however, raised again. With a low room temperature, the improved installations often tend to result in better comfort rather than in energy savings. The project has been implemented during a three-year period from the heating season 97/98 to 99/00. Before the first heating season 97/98, energy and flow meters were installed for measuring the existing heating and hot water consumption in each building. For the second heating season 98/99, various energy saving measures were installed, and measurements were carried out again. After that, the energy consumption and temperature levels were analysed and compared for the two seasons. The results are shown in this report. In the third heating season 99/00, an extra set of measurements was carried out in order to verify the results from the season from 98/99 and to analyse the development in the savings and temperatures. (au)

  20. Integrated headgear for the future force warrior: results of the first field evaluations

    Science.gov (United States)

    Schuyler, W. Jeff; Melzer, James E.

    2007-04-01

    The development of an advanced ground soldier's integrated headgear system for the Army's Future Force Warrior Program passed a major milestone during 2006. Field testing of functional headgear systems by small combat units demonstrated that the headgear capabilities were mature enough to move beyond the advanced technology demonstration (ATD) phase. This paper will describe the final system with test results from the three field exercises and will address the strengths and weaknesses of the headgear system features, head mounted sensors, displays and sensor fusion.