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Sample records for evaluation interim results

  1. Alternative fuel transit buses: Interim results from the National Renewable Energy Laboratory (NREL) Vehicle Evaluation Program

    Energy Technology Data Exchange (ETDEWEB)

    Motta, R.; Norton, P.; Kelly, K.J.; Chandler, K.

    1995-05-01

    The transit bus program is designed to provide a comprehensive study of the alternative fuels currently used by the transit bus industry. The study focuses on the reliability, fuel economy, operating costs, and emissions of vehicles running on the various fuels and alternative fuel engines. The alternative fuels being tested are methanol, ethanol, biodiesel and natural gas. The alternative fuel buses in this program use the most common alternative fuel engines from the heavy-duty engine manufacturers. Data are collected in four categories: Bus and route descriptions; Bus operating data; Emissions data; and, Capital costs. The goal is to collect 18 months of data on each test bus. This report summarizes the interim results from the project to date. The report addresses performance and reliability, fuel economy, costs, and emissions of the busses in the program.

  2. Evaluation of ERA-Interim precipitation data in complex terrain

    Science.gov (United States)

    Gao, Lu; Bernhardt, Matthias; Schulz, Karsten

    2013-04-01

    Precipitation controls a large variety of environmental processes, which is an essential input parameter for land surface models e.g. in hydrology, ecology and climatology. However, rain gauge networks provides the necessary information, are commonly sparse in complex terrains, especially in high mountainous regions. Reanalysis products (e.g. ERA-40 and NCEP-NCAR) as surrogate data are increasing applied in the past years. Although they are improving forward, previous studies showed that these products should be objectively evaluated due to their various uncertainties. In this study, we evaluated the precipitation data from ERA-Interim, which is a latest reanalysis product developed by ECMWF. ERA-Interim daily total precipitation are compared with high resolution gridded observation dataset (E-OBS) at 0.25°×0.25° grids for the period 1979-2010 over central Alps (45.5-48°N, 6.25-11.5°E). Wet or dry day is defined using different threshold values (0.5mm, 1mm, 5mm, 10mm and 20mm). The correspondence ratio (CR) is applied for frequency comparison, which is the ratio of days when precipitation occurs in both ERA-Interim and E-OBS dataset. The result shows that ERA-Interim captures precipitation occurrence very well with a range of CR from 0.80 to 0.97 for 0.5mm to 20mm thresholds. However, the bias of intensity increases with rising thresholds. Mean absolute error (MAE) varies between 4.5 mm day-1 and 9.5 mm day-1 in wet days for whole area. In term of mean annual cycle, ERA-Interim almost has the same standard deviation of the interannual variability of daily precipitation with E-OBS, 1.0 mm day-1. Significant wet biases happened in ERA-Interim throughout warm season (May to August) and dry biases in cold season (November to February). The spatial distribution of mean annual daily precipitation shows that ERA-Interim significant underestimates precipitation intensity in high mountains and northern flank of Alpine chain from November to March while pronounced

  3. Report of the evaluation by the Ad Hoc Review Committee on Advance Science Research. Result evaluation, interim evaluation, in-advance evaluation in fiscal year 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The Research Evaluation Committee, which consisted of 13 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Advanced Science Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the accomplishments of the research completed in Fiscal Year 2001, the accomplishments of the research started in Fiscal Year 2000, and the adequacy of the programs of the research to be started in Fiscal Year 2003 at Advanced Science Research Center of JAERI. The Ad Hoc Review Committee consisted of eight specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from May to July 2002. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on June 4, 2002, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on August 5, 2002. This report describes the result of the evaluation by the Ad Hoc Review Committee on Advanced Science Research. (author)

  4. Implementation and adoption of nationwide electronic health records in secondary care in England: qualitative analysis of interim results from a prospective national evaluation

    Science.gov (United States)

    Robertson, Ann; Cresswell, Kathrin; Takian, Amirhossein; Petrakaki, Dimitra; Crowe, Sarah; Cornford, Tony; Barber, Nicholas; Avery, Anthony; Fernando, Bernard; Jacklin, Ann; Prescott, Robin; Klecun, Ela; Paton, James; Lichtner, Valentina; Quinn, Casey; Ali, Maryam; Morrison, Zoe; Jani, Yogini; Waring, Justin; Marsden, Kate

    2010-01-01

    Objectives To describe and evaluate the implementation and adoption of detailed electronic health records in secondary care in England and thereby provide early feedback for the ongoing local and national rollout of the NHS Care Records Service. Design A mixed methods, longitudinal, multisite, socio-technical case study. Setting Five NHS acute hospital and mental health trusts that have been the focus of early implementation efforts and at which interim data collection and analysis are complete. Data sources and analysis Dataset for the evaluation consists of semi-structured interviews, documents and field notes, observations, and quantitative data. Qualitative data were analysed thematically with a socio-technical coding matrix, combined with additional themes that emerged from the data. Main results Hospital electronic health record applications are being developed and implemented far more slowly than was originally envisioned; the top-down, standardised approach has needed to evolve to admit more variation and greater local choice, which hospital trusts want in order to support local activity. Despite considerable delays and frustrations, support for electronic health records remains strong, including from NHS clinicians. Political and financial factors are now perceived to threaten nationwide implementation of electronic health records. Interviewees identified a range of consequences of long term, centrally negotiated contracts to deliver the NHS Care Records Service in secondary care, particularly as NHS trusts themselves are not party to these contracts. These include convoluted communication channels between different stakeholders, unrealistic deployment timelines, delays, and applications that could not quickly respond to changing national and local NHS priorities. Our data suggest support for a “middle-out” approach to implementing hospital electronic health records, combining government direction with increased local autonomy, and for restricting

  5. AES Water Architecture Study Interim Results

    Science.gov (United States)

    Sarguisingh, Miriam J.

    2012-01-01

    The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems in order to enable NASA human exploration missions beyond low earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near term missions beyond LEO. The secondary objective is to continue to advance mid-readiness level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near and long term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit environmental control and life support systems (ECLSS) definition. This study is being performed in three phases. Phase I of this study established the scope of the study through definition of the mission requirements and constraints, as well as indentifying all possible WRS configurations that meet the mission requirements. Phase II of this study focused on the near term space exploration objectives by establishing an ISS-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

  6. SWSA 6 interim corrective measures environmental monitoring: FY 1990 results

    Energy Technology Data Exchange (ETDEWEB)

    Ashwood, T.L.; Spalding, B.P.

    1991-07-01

    This report presents the results and conclusions from a multifaceted monitoring effort associated with the high-density polyethylene caps installed in Solid Waste Storage Area (SWSA) 6 at Oak Ridge National Laboratory (ORNL) as an interim corrective measure (ICM). The caps were installed between November 1988 and June 1989 to meet Resource Conservation and Recovery Act (RCRA) requirements for closure of those areas of SWSA 6 that had received RCRA-regulated wastes after November 1980. Three separate activities were undertaken to evaluate the performance of the caps: (1) wells were installed in trenches to be covered by the caps, and water levels in these intratrench wells were monitored periodically; (2) samples were taken of the leachate in the intratrench wells and were analyzed for a broad range of radiological and chemical contaminants; and (3) water levels in wells outside the trenches were monitored periodically. With the exception of the trench leachate sampling, each of these activities spanned the preconstruction, construction, and postconstruction periods. Findings of this study have important implications for the ongoing remedial investigation in SWSA 6 and for the design of other ICMs. 51 figs., 2 tabs.

  7. Evaluation of the Safety and Effectiveness of Add-On Tacrolimus in Patients with Rheumatoid Arthritis Who Failed to Show an Adequate Response to Biological DMARDs: The Interim Results of a Specific Drug Use-Results Survey of Tacrolimus.

    Science.gov (United States)

    Ishida, Kota; Shiraki, Katsuhisa; Yoshiyasu, Takashi

    2015-12-01

    Tacrolimus (TAC) is an immunosuppressive macrolide that blocks T-cell activation by specifically inhibiting calcineurin. TAC was approved in Japan for the treatment of rheumatoid arthritis (RA) in 2005. However, the safety and effectiveness of TAC adding on to biological disease-modifying anti-rheumatic drugs (DMARDs) in the real clinical setting may not be clear enough. We report here the interim results of post marketing surveillance (PMS) of TAC adding on to biological DMARDs in RA patients who failed to show an adequate response to biological DMARDs. Patients who had an inadequate response to biological DMARDs were enrolled. An inadequate response to biological DMARDs was defined as that all of the following conditions were met: a Simplified Disease Activity Index (SDAI) score of >3.3 when TAC was started; both the tender joint count and swollen joint count were the same or increased compared with those at 4-8 weeks prior to TAC; and biological DMARDs were used for at least 8 weeks prior to TAC. This study was conducted in compliance with the ministerial ordinance on "Good Post-Marketing Study Practice" (GPSP). The safety data collection and evaluation for 172 patients and effectiveness data collection and evaluation for 165 patients were reported. The mean age was 61.9 years. Adverse drug reactions occurred in 18 patients. The mean SDAI decreased from 20.1 at baseline to 11.7 at week 24. TAC is well tolerated and effective when added on to biological DMARDs in RA patients who failed to achieve an adequate response to biological DMARDs.

  8. Evaluation of hardness and wear resistance of interim restorative materials.

    Science.gov (United States)

    Savabi, Omid; Nejatidanesh, Farahnaz; Fathi, Mohamad Hossein; Navabi, Amir Arsalan; Savabi, Ghazal

    2013-03-01

    The interim restorative materials should have certain mechanical properties to withstand in oral cavity. The aim of this study was to evaluate the hardness and wear resistance of interim restorative materials. Fifteen identical rectangular shape specimens with dimensions of 2 mm × 10 mm × 30 mm were made from 7 interim materials (TempSpan, Protemp 3 Garant, Revotek, Unifast LC, Tempron, Duralay, and Acropars). The Vickers hardness and abrasive wear of specimens were tested in dry conditions and after 1 week storage in artificial saliva. The depth of wear was measured using surface roughness inspection device. Data were subjected to Kruskal-Wallis and Mann-Whitney tests. The Pearson correlation coefficient was used to determine the relationship between hardness and wear (α =0.05). TempSpan had the highest hardness. The wear resistance of TempSpan (in dry condition) and Revotek (after conditioning in artificial saliva) was significantly higher (P materials (P = 0.281, r = -0.31). Hardness and wear resistance of interim resins are material related rather than category specified.

  9. Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis

    DEFF Research Database (Denmark)

    Home, Philip D; Pocock, Stuart J; Beck-Nielsen, Henning

    2007-01-01

    BACKGROUND: A recent meta-analysis raised concern regarding an increased risk of myocardial infarction and death from cardiovascular causes associated with rosiglitazone treatment of type 2 diabetes. METHODS: We conducted an unplanned interim analysis of a randomized, multicenter, open-label, non......BACKGROUND: A recent meta-analysis raised concern regarding an increased risk of myocardial infarction and death from cardiovascular causes associated with rosiglitazone treatment of type 2 diabetes. METHODS: We conducted an unplanned interim analysis of a randomized, multicenter, open...... group). The primary end point was hospitalization or death from cardiovascular causes. RESULTS: Because the mean follow-up was only 3.75 years, our interim analysis had limited statistical power to detect treatment differences. A total of 217 patients in the rosiglitazone group and 202 patients...... group and the control group regarding myocardial infarction and death from cardiovascular causes or any cause. There were more patients with heart failure in the rosiglitazone group than in the control group (hazard ratio, 2.15; 95% CI, 1.30 to 3.57). CONCLUSIONS: Our interim findings from this ongoing...

  10. Evaluation of the Healthy Schools Program: Part I. Interim Progress

    OpenAIRE

    Beam, Margaret; Ehrlich, Ginny; Donze Black, Jessica; Block, Audrey; Leviton, Laura C.

    2012-01-01

    Introduction Federal and state policies identify schools as a setting to prevent childhood obesity, but schools need better health-promoting strategies. The objective of this study was to evaluate interim progress in schools receiving hands-on training from the Healthy Schools Program, the nation's largest school-based program aimed at preventing childhood obesity. The 4-year program targets schools with predominantly low-income, African American, or Hispanic students. Methods In 2010 we asse...

  11. Evaluation of the deposition, translocation and pathological response of brake dust with and without added chrysotile in comparison to crocidolite asbestos following short-term inhalation: Interim results

    Energy Technology Data Exchange (ETDEWEB)

    Bernstein, David M., E-mail: davidb@itox.ch [Consultant in Toxicology, 1208 Geneva (Switzerland); Rogers, Rick, E-mail: rarogers5@yahoo.com [Rogers Imaging, Needham, MA 02494 (United States); Sepulveda, Rosalina [Rogers Imaging, Needham, MA 02494 (United States); Kunzendorf, Peter, E-mail: Peter.Kunzendorf@GSA-Ratingen.de [GSA Gesellschaft für Schadstoffanalytik mbH, D-40882 Ratingen (Germany); Bellmann, Bernd [Fraunhofer Institute for Toxicology and Experimental Medicine, D-30625 Hannover (Germany); Ernst, Heinrich, E-mail: Heinrich.ernst@item.fraunhofer.de [Fraunhofer Institute for Toxicology and Experimental Medicine, D-30625 Hannover (Germany); Phillips, James I., E-mail: jim.phillips@nioh.nhls.ac.za [National Institute for Occupational Health, National Health Laboratory Service (South Africa); Department of Biomedical Technology, Faculty of Health Sciences, University of Johannesburg (South Africa)

    2014-04-01

    Chrysotile has been frequently used in the past in manufacturing brakes and continues to be used in brakes in many countries. This study was designed to provide an understanding of the biokinetics and potential toxicology following inhalation of brake dust following short term exposure in rats. The deposition, translocation and pathological response of brake dust derived from brake pads manufactured with chrysotile were evaluated in comparison to the amphibole, crocidolite asbestos. Rats were exposed by inhalation 6 h/day for 5 days to either brake dust obtained by sanding of brake-drums manufactured with chrysotile, a mixture of chrysotile and the brake dust or crocidolite asbestos. No significant pathological response was observed at any time point in either the brake dust or chrysotile/brake dust exposure groups. The long chrysotile fibers (> 20 μm) cleared quickly with T{sub 1/2} estimated as 30 and 33 days, respectively in the brake dust and the chrysotile/brake dust exposure groups. In contrast, the long crocidolite fibers had a T{sub 1/2} > 1000 days and initiated a rapid inflammatory response in the lung following exposure resulting in a 5-fold increase in fibrotic response within 91 days. These results provide support that brake dust derived from chrysotile containing brake drums would not initiate a pathological response in the lung following short term inhalation. - Highlights: • We evaluated brake dust w/wo added chrysotile in comparison to crocidolite asbestos. • Persistence, translocation, pathological response in the lung and pleural cavity. • Chrysotile cleared rapidly from the lung while the crocidolite asbestos persisted. • No significant pathology observed at any time point in the brake-dust groups. • Crocidolite produced pathological response - Wagner 4 interstitial fibrosis by 32d.

  12. Interim report on nodel evaluation methodology and the evaluation of LEAP

    Energy Technology Data Exchange (ETDEWEB)

    Alsmiller, R.G. Jr.; Barish, J.; Bjornstad, D.

    1980-04-01

    This report describes progress made at ORNL toward development and demonstration of a methodology for evaluating energy-economic modeling codes and important results derived from these codes. To bolster traditional evaluation methods with more-quantitative procedures of interest to the Energy Information Administration, ORNL is applying sensitivity theory as part of a comprehensive effort to quantify the importance of various data and model parameters to the key results that are of interest. The Long-Term Energy Analysis Program (LEAP) was chosen as the initial focus for the research. LEAP is an energy-economy model which resides in the Long-Term Energy Analysis Division (LTEAD) of the Integrative Analysis Group in the Office of Applied Analysis, EIA. LTEAD developed Model 22C of LEAP for two reasons: (1) to prepare projections through the year 2020, which were needed for the 1978 EIA Annual Report to Congress and (2) to develop a base for analyses of specific options for Federal action. LEAP Model 22C and its uses are described to provide the background for this interim description of the model evaluation effort at ORNL. 19 figures, 10 tables.

  13. Interim Evaluation of the Project P.A.T.H.S.: Findings Based on Different Datasets

    Directory of Open Access Journals (Sweden)

    Daniel T. L. Shek

    2012-01-01

    Full Text Available Interim evaluation studies were carried out in order to examine the implementation details of the Tier 1 Program of the Project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programmes in Hong Kong. Quantitative results of the interim evaluation findings based on eight datasets collected from 2006 to 2009 are reported in this paper. Three hundred and seventy-eight schools were randomly selected to provide information on the implementation details of the program via face-to-face interviews, telephone interviews, and self-completed questionnaires. Results showed that a majority of the workers perceived that the students had positive responses to the program and the program was helpful to the students. In conjunction with other process evaluation findings, the present study suggests that the implementation quality of the Tier 1 Program of the Project P.A.T.H.S. is high. The present study also provides support for the effectiveness of the Tier 1 Program of the Project P.A.T.H.S. in Hong Kong.

  14. Global Spent Fuel Logistics Systems Study (GSFLS). Volume 2. GSFLS visit findings and evaluations. Interim report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-31

    This report is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. This report describes a global framework that evaluates spent fuel disposition requirements, influencing factors and strategies. A broad sampling of foreign governmental officials, electric utility spokesmen and nuclear power industry officials responsible for GSFLS policies, plans and programs were surveyed as to their views with respect to national and international GSFLS related considerations. The results of these GSFLS visit findings are presented herein. These findings were then evaluated in terms of technical, institutional and legal/regulatory implications. The GSFLS evaluations, in conjunction with perceived US spent fuel objectives, formed the basis for selecting a set of GSFLS strategies which are reported herein.

  15. Telephoning of interim blood culture results: a regional survey.

    Science.gov (United States)

    Petkar, H M; Breathnach, A S

    2008-10-01

    Most staphylococci grown from blood cultures are contaminants. Since they are microscopically indistinguishable from non-contaminants, considerable time and resources may be spent following up all patients with positive blood cultures before the identification is made the following day. Since there is no formal guidance or standard available in this area, this report surveyed practice in our region. An interview was conducted by telephone, using a standardised questionnaire. Results were analysed using descriptive techniques. The majority of microbiologists did not communicate all presumptive staphylococci but waited for identification in some cases. There is a range of practice in laboratories due to conflicting pressures: limited time, fear of criticism if results are not phoned, fear of causing confusion with provisional information and lack of clarity concerning what is "good practice." This survey concludes that a decision not to telephone every presumptive Staphylococcus in blood cultures on Day 1 is reasonable.

  16. SWSA 6 interim corrective measures environmental monitoring: FY 1990 results. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Ashwood, T.L.; Spalding, B.P.

    1991-07-01

    This report presents the results and conclusions from a multifaceted monitoring effort associated with the high-density polyethylene caps installed in Solid Waste Storage Area (SWSA) 6 at Oak Ridge National Laboratory (ORNL) as an interim corrective measure (ICM). The caps were installed between November 1988 and June 1989 to meet Resource Conservation and Recovery Act (RCRA) requirements for closure of those areas of SWSA 6 that had received RCRA-regulated wastes after November 1980. Three separate activities were undertaken to evaluate the performance of the caps: (1) wells were installed in trenches to be covered by the caps, and water levels in these intratrench wells were monitored periodically; (2) samples were taken of the leachate in the intratrench wells and were analyzed for a broad range of radiological and chemical contaminants; and (3) water levels in wells outside the trenches were monitored periodically. With the exception of the trench leachate sampling, each of these activities spanned the preconstruction, construction, and postconstruction periods. Findings of this study have important implications for the ongoing remedial investigation in SWSA 6 and for the design of other ICMs. 51 figs., 2 tabs.

  17. Advanced Stirling Convertor Durability Testing: Plans and Interim Results

    Science.gov (United States)

    Meer, David W.; Oriti, Salvatore M.

    2012-01-01

    The U.S. Department of Energy (DOE), Lockheed Martin Corporation (LM), and NASA Glenn Research Center (GRC) have been developing the Advanced Stirling Radioisotope Generator (ASRG) for use as a power system for space science missions. In support of this program, GRC has been involved in testing Stirling convertors, including the Advanced Stirling Convertor (ASC), for use in the ASRG. This testing includes electromagnetic interference/compatibility (EMI/EMC), structural dynamics, advanced materials, organics, and unattended extended operation. The purpose of the durability tests is to experimentally demonstrate the margins in the ASC design. Due to the high value of the hardware, previous ASC tests focused on establishing baseline performance of the convertors within the nominal operating conditions. The durability tests present the first planned extension of the operating conditions into regions beyond those intended to meet the product spec, where the possibility exists of lateral contact, overstroke, or over-temperature events. These tests are not intended to cause damage that would shorten the life of the convertors, so they can transition into extended operation at the conclusion of the tests. This paper describes the four tests included in the durability test sequence: 1) start/stop cycling, 2) exposure to constant acceleration in the lateral and axial directions, 3) random vibration at increased piston amplitude to induce contact events, and 4) overstroke testing to simulate potential failures during processing or during the mission life where contact events could occur. The paper also summarizes the analysis and simulation used to predict the results of each of these tests.

  18. Weatherization Works: An interim report of the National Weatherization Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A.; Berry, L.G. [Oak Ridge National Lab., TN (United States); Kinney, L.F. [Synertech Systems Corp., Syracuse, NY (United States)

    1993-11-01

    The National Weatherization Evaluation is the first comprehensive evaluation of the Weatherization Assistance Program since 1984. The evaluation was designed to accomplish the following goals: Estimate energy savings and cost effectiveness; Assess nonenergy impacts; Describe the weatherization network; Characterize the eligible population and resources; and Identify factors influencing outcomes and opportunities for the future. As a national program, weatherization incorporates considerable diversity due to regional differences. Therefore, evaluation results are presented both in aggregate and for three climate regions: cold, moderate and hot.

  19. In vitro evaluation of the marginal integrity of CAD/CAM interim crowns.

    Science.gov (United States)

    Kelvin Khng, Kwang Yong; Ettinger, Ronald L; Armstrong, Steven R; Lindquist, Terry; Gratton, David G; Qian, Fang

    2016-05-01

    The accuracy of interim crowns made with computer-aided design and computer-aided manufacturing (CAD/CAM) systems has not been well investigated. The purpose of this in vitro study was to evaluate the marginal integrity of interim crowns made by CAD/CAM compared with that of conventional polymethylmethacrylate (PMMA) crowns. A dentoform mandibular left second premolar was prepared for a ceramic crown and scanned for the fabrication of 60 stereolithical resin dies, half of which were scanned to fabricate 15 Telio CAD-CEREC and 15 Paradigm MZ100-E4D-E4D crowns. Fifteen Caulk and 15 Jet interim crowns were made on the remaining resin dies. All crowns were cemented with Tempgrip under a 17.8-N load, thermocycled for 1000 cycles, placed in 0.5% acid fuschin for 24 hours, and embedded in epoxy resin before sectioning from the mid-buccal to mid-lingual surface. The marginal discrepancy was measured using a traveling microscope, and dye penetration was measured as a percentage of the overall length under the crown. The mean vertical marginal discrepancy of the conventionally made interim crowns was greater than for the CAD/CAM crowns (P=.006), while no difference was found for the horizontal component (P=.276). The mean vertical marginal discrepancy at the facial surface of the Caulk crowns was significantly greater than that of the other 3 types of interim crowns (Pcrowns was significantly larger than that of the other 3 types, with no difference at the lingual margins (P=.150). The mean percentage dye penetration for the Paradigm MZ100-E4D crowns was significantly greater and for Jet crowns significantly smaller than for the other 3 crowns (Pcrowns at the facial surface and with the horizontal marginal discrepancies of the Caulk interim crowns at the lingual surface (Pcrowns fabricated by CAD/CAM as compared with PMMA crowns; however, this difference was not observed for the horizontal component. The percentage dye penetration was correlated with vertical and horizontal

  20. Immediate loading of trabecular metal-enhanced titanium dental implants: interim results from an international proof-of-principle study.

    Science.gov (United States)

    Schlee, Marcus; van der Schoor, W Peter; van der Schoor, Alexandra R M

    2015-01-01

    A 3-year proof-of-principle study was initiated to evaluate the clinical efficacy of immediately loading titanium dental implants with surfaces enhanced with porous tantalum trabecular metal (PTTM). First-year interim results are presented. Healthy, partially edentulous patients (n = 30) were enrolled and treated per protocol (minimum insertion torque: ≥35 Ncm) with 37 implants placed in one or two premolar or molar locations in either jaw (study group). Implants were immediately provisionalized out of occlusion with single acrylic crowns. After 7 to 14 days of soft tissue healing, implants were definitively restored in occlusion with ceramometal crowns. Because most study group implants (54.1%, n = 20) had less than 1 year of clinical follow-up, this interim analysis was limited to the first 22 consecutively placed implants in 17 subjects (10 women and 7 men) who completed 1 year of clinical follow-up to date (focus group). To date, one implant failed to integrate in the study group (survival = 97.3%, n = 36/37). Focus group implants achieved 100% (n = 22/22) survival with 0.43 ± 0.41 mm of mean marginal bone loss. There were no serious complications. Early clinical findings indicated that immediate loading of PTTM implants was safe and effective under the controlled study conditions. © 2013 The Authors. Clinical Implant Dentistry and Related Research published by Wiley Periodicals, Inc.

  1. Evaluation of 3-D laser scanning equipment : 2016 interim report.

    Science.gov (United States)

    2017-05-01

    As a follow-up to ICT Project R27-030, Evaluation of 3-D Laser Scanning, this report provides findings of an evaluation of 3-D laser : scanning equipment to determine the tangible costs versus benefits and the manpower savings realized by using the e...

  2. Sample results from the interim salt disposition program macrobatch 9 tank 21H qualification samples

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-11-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 9 for the Interim Salt Disposition Program (ISDP). This document reports characterization data on the samples of Tank 21H.

  3. Sample results from the Interim Salt Disposition Program Macrobatch 8 Tank 21H qualification samples

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Washington, II, A. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-01-13

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 8 for the Interim Salt Disposition Program (ISDP). An Actinide Removal Process (ARP) and several Extraction-Scrub-Strip (ESS) tests were also performed. This document reports characterization data on the samples of Tank 21H as well as simulated performance of ARP and the Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU). No issues with the projected Salt Batch 8 strategy are identified. A demonstration of the monosodium titanate (MST) (0.2 g/L) removal of strontium and actinides provided acceptable average decontamination factors for plutonium of 2.62 (4 hour) and 2.90 (8 hour); and average strontium decontamination factors of 21.7 (4 hour) and 21.3 (8 hour). These values are consistent with results from previous salt batch ARP tests. The two ESS tests also showed acceptable performance with extraction distribution ratios (D(Cs)) values of 52.5 and 50.4 for the Next Generation Solvent (NGS) blend (from MCU) and NGS (lab prepared), respectively. These values are consistent with results from previous salt batch ESS tests. Even though the performance is acceptable, SRNL recommends that a model for predicting extraction behavior for cesium removal for the blended solvent and NGS be developed in order to improve our predictive capabilities for the ESS tests.

  4. Sample Results from the Interim Salt Disposition Program Macrobatch 8 Tank 21H Qualification Samples

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Washington, A. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-01-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 8 for the Interim Salt Disposition Program (ISDP). An Actinide Removal Process (ARP) and several Extraction-Scrub- Strip (ESS) tests were also performed. This document reports characterization data on the samples of Tank 21H as well as simulated performance of ARP and the Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU). No issues with the projected Salt Batch 8 strategy are identified. A demonstration of the monosodium titanate (MST) (0.2 g/L) removal of strontium and actinides provided acceptable average decontamination factors for plutonium of 2.62 (4 hour) and 2.90 (8 hour); and average strontium decontamination factors of 21.7 (4 hour) and 21.3 (8 hour). These values are consistent with results from previous salt batch ARP tests. The two ESS tests also showed acceptable performance with extraction distribution ratios (D(Cs)) values of 52.5 and 50.4 for the Next Generation Solvent (NGS) blend (from MCU) and NGS (lab prepared), respectively. These values are consistent with results from previous salt batch ESS tests. Even though the performance is acceptable, SRNL recommends that a model for predicting extraction behavior for cesium removal for the blended solvent and NGS be developed in order to improve our predictive capabilities for the ESS tests.

  5. Interim results from UO/sub 2/ fuel oxidation tests in air

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, T.K.; Gilbert, E.R.; Thornhill, C.K.; White, G.D.; Piepel, G.F.; Griffin, C.W.j

    1987-08-01

    An experimental program is being conducted at Pacific Northwest Laboratory (PNL) to extend the characterization of spent fuel oxidation in air. To characterize oxidation behavior of irradiated UO/sub 2/, fuel oxidation tests were performed on declad light-water reactor spent fuel and nonirradited UO/sub 2/ pellets in the temperature range of 135 to 250/sup 0/C. These tests were designed to determine the important independent variables that might affect spent fuel oxidation behavior. The data from this program, when combined with the test results from other programs, will be used to develop recommended spent fuel dry-storage temperature limits in air. This report describes interim test results. The initial PNL investigations of nonirradiated and spent fuels identified the important testing variables as temperature, fuel burnup, radiolysis of the air, fuel microstructure, and moisture in the air. Based on these initial results, a more extensive statistically designed test matrix was developed to study the effects of temperature, burnup, and moisture on the oxidation behavior of spent fuel. Oxidation tests were initiated using both boiling-water reactor and pressurized-water reactor fuels from several different reactors with burnups from 8 to 34 GWd/MTU. A 10/sup 5/ R/h gamma field was applied to the test ovens to simulate dry storage cask conditions. Nonirradiated fuel was included as a control. This report describes experimental results from the initial tests on both the spent and nonirradiated fuels and results to date on the tests in a 10/sup 5/ R/h gamma field. 33 refs., 51 figs., 6 tabs.

  6. 76 FR 58846 - Final Interim Staff Guidance: Review of Evaluation To Address Gas Accumulation Issues in Safety...

    Science.gov (United States)

    2011-09-22

    ... COMMISSION Final Interim Staff Guidance: Review of Evaluation To Address Gas Accumulation Issues in Safety...-ISG-019 on ``Review of Evaluation to Address Gas Accumulation Issues in Safety Related Systems... is to clarify the NRC staff guidance to address issues of gas accumulation in safety related systems...

  7. Results from the Interim Salt Disposition Program Macrobatch 11 Tank 21H Acceptance Samples

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-11-13

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of verification of Macrobatch (Salt Batch) 11 for the Interim Salt Disposition Program (ISDP) for processing. This document reports characterization data on the samples of Tank 21H and fulfills the requirements of Deliverable 3 of the Technical Task Request (TTR).

  8. Sample results from the interim salt disposition program macrobatch 8 tank 21H qualification MST solids sample

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Washington, A. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-02-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 8 for Interim Salt Disposition Program (ISDP) processing. As part of this qualification work, SRNL performed an Actinide Removal Process (ARP) and several Extraction, Scrub, Strip (ESS) tests. This document reports characterization of the monosodium titanate (MST) solids from the ARP test. The results of these analyses are reported and are within historical precedent.

  9. Early interim {sup 18}F-FDG PET in Hodgkin's lymphoma: evaluation on 304 patients

    Energy Technology Data Exchange (ETDEWEB)

    Zinzani, Pier Luigi; Stefoni, Vittorio; Broccoli, Alessandro; Argnani, Lisa; Baccarani, Michele [University of Bologna, Institute of Hematology and Medical Oncology ' ' L. e A. Seragnoli' ' , Policlinico ' ' Sant' Orsola-Malpighi' ' , Bologna (Italy); Rigacci, Luigi; Puccini, Benedetta [Azienda Ospedaliero Universitaria ' ' Careggi' ' , Hematology Department, Florence (Italy); Castagnoli, Antonio [Ospedale ' ' Misericordia e Dolce' ' , Nuclear Medicine, Prato (Italy); Vaggelli, Luca [Azienda Ospedaliero Universitaria ' ' Careggi' ' , Nuclear Medicine, Florence (Italy); Zanoni, Lucia; Fanti, Stefano [Policlinico ' ' Sant' Orsola-Malpighi' ' , Department of Nuclear Medicine, Bologna (Italy)

    2012-01-15

    The use of early (interim) PET restaging during first-line therapy of Hodgkin's lymphoma (HL) in clinical practice has considerably increased because of its ability to provide early recognition of treatment failure allowing patients to be transferred to more intensive treatment regimens. Between June 1997 and June 2009, 304 patients with newly diagnosed HL (147 early stage and 157 advanced stage) were treated with the ABVD regimen at two Italian institutions. Patients underwent PET staging and restaging at baseline, after two cycles of therapy and at the end of the treatment. Of the 304 patients, 53 showed a positive interim PET scan and of these only 13 (24.5%) achieved continuous complete remission (CCR), whereas 251 patients showed a negative PET scan and of these 231 (92%) achieved CCR. Comparison between interim PET-positive and interim PET-negative patients indicated a significant association between PET findings and 9-year progression-free survival and 9-year overall survival, with a median follow-up of 31 months. Among the early-stage patients, 19 had a positive interim PET scan and only 4 (21%) achieved CCR; among the 128 patients with a negative interim PET scan, 122 (97.6%) achieved CCR. Among the advanced-stage patients, 34 showed a persistently positive PET scan with only 9 (26.4%) achieving CCR, whereas 123 showed a negative interim PET scan with 109 (88.6%) achieving CCR. Our results demonstrate the role of an early PET scan as a significant step forward in the management of patients with early-stage or advanced-stage HL. (orig.)

  10. Interim radiological safety standards and evaluation procedures for subseabed high-level waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Klett, R.D.

    1997-06-01

    The Seabed Disposal Project (SDP) was evaluating the technical feasibility of high-level nuclear waste disposal in deep ocean sediments. Working standards were needed for risk assessments, evaluation of alternative designs, sensitivity studies, and conceptual design guidelines. This report completes a three part program to develop radiological standards for the feasibility phase of the SDP. The characteristics of subseabed disposal and how they affect the selection of standards are discussed. General radiological protection standards are reviewed, along with some new methods, and a systematic approach to developing standards is presented. The selected interim radiological standards for the SDP and the reasons for their selection are given. These standards have no legal or regulatory status and will be replaced or modified by regulatory agencies if subseabed disposal is implemented. 56 refs., 29 figs., 15 tabs.

  11. INDEPENDENT TECHNICAL REVIEW OF THE C-400 INTERIM REMEDIAL PROJECT PHASE I RESULTS, PADUCAH, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Rossabi, J.; Stewart,L.; Richards, W.

    2010-10-29

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in

  12. Cost Sensitivity Analysis for Consolidated Interim Storage of Spent Fuel: Evaluating the Effect of Economic Environment Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Cumberland, Riley M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Kent Alan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jarrell, Joshua J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Joseph, III, Robert Anthony [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-12-01

    This report evaluates how the economic environment (i.e., discount rate, inflation rate, escalation rate) can impact previously estimated differences in lifecycle costs between an integrated waste management system with an interim storage facility (ISF) and a similar system without an ISF.

  13. 76 FR 72006 - Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon...

    Science.gov (United States)

    2011-11-21

    ... COMMISSION Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon... Recovery Facility Surveys of Radon and Radon Progeny in Air and Demonstrations of Compliance with 10 CFR 20... that existing guidance does not sufficiently detail how the NRC staff reviews surveys of radon and...

  14. Effects of an Advocacy Trial on Food Industry Salt Reduction Efforts-An Interim Process Evaluation.

    Science.gov (United States)

    Trevena, Helen; Petersen, Kristina; Thow, Anne Marie; Dunford, Elizabeth K; Wu, Jason H Y; Neal, Bruce

    2017-10-17

    The decisions made by food companies are a potent factor shaping the nutritional quality of the food supply. A number of non-governmental organizations (NGOs) advocate for corporate action to reduce salt levels in foods, but few data define the effectiveness of advocacy. This present report describes the process evaluation of an advocacy intervention delivered by one Australian NGO directly to food companies to reduce the salt content of processed foods. Food companies were randomly assigned to intervention (n = 22) or control (n = 23) groups. Intervention group companies were exposed to pre-planned and opportunistic communications, and control companies to background activities. Seven pre-defined interim outcome measures provided an indication of the effect of the intervention and were assessed using intention-to-treat analysis. These were supplemented by qualitative data from nine semi-structured interviews. The mean number of public communications supporting healthy food made by intervention companies was 1.5 versus 1.8 for control companies (p = 0.63). Other outcomes, including the mean number of news articles, comments and reports (1.2 vs. 1.4; p = 0.72), a published nutrition policy (23% vs. 44%; p = 0.21), public commitment to the Australian government's Food and Health Dialogue (FHD) (41% vs. 61%; p = 0.24), evidence of a salt reduction plan (23% vs. 30%; p = 0.56), and mean number of communications with the NGO (15 vs. 11; p = 0.28) were also not significantly different. Qualitative data indicated the advocacy trial had little effect. The absence of detectable effects of the advocacy intervention on the interim markers indicates there may be no impact of the NGO advocacy trial on the primary outcome of salt reduction in processed foods.

  15. Emulytics for Cyber-Enabled Physical Attack Scenarios: Interim LDRD Report of Year One Results.

    Energy Technology Data Exchange (ETDEWEB)

    Clem, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Urias, Vincent [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Atkins, William Dee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Symonds, Christopher J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-08

    Sandia National Laboratories has funded the research and development of a new capability to interactively explore the effects of cyber exploits on the performance of physical protection systems. This informal, interim report of progress summarizes the project’s basis and year one (of two) accomplishments. It includes descriptions of confirmed cyber exploits against a representative testbed protection system and details the development of an emulytics capability to support live, virtual, and constructive experiments. This work will support stakeholders to better engineer, operate, and maintain reliable protection systems.

  16. Results from the interim salt disposition program macrobatch 10 tank 21H qualification samples

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-02-23

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 10 for the Interim Salt Disposition Program (ISDP). This document reports characterization data on the samples of Tank 21H and fulfills the requirements of Deliverable 3 of the Technical Task Request (TTR). Further work will report the results of the Extraction-Scrub-Strip (ESS) testing (Task 5 of the TTR) using the Tank 21H material. Task 4 of the TTR (MST Strike) will not be completed for Salt Batch 10.

  17. Evaluation of flexural strength of resin interim restorations impregnated with various types of silane treated and untreated glass fibres.

    Science.gov (United States)

    Naveen, K S; Singh, J P; Viswambaran, M; Dhiman, R K

    2015-12-01

    Flexural strength is an important mechanical property that determines the long-term prognosis of interim restorations. Studies are lacking regarding the effect of silanation of the various types of glass fibre impregnation on the flexural strength of resin interim restorations. A customized metal die was milled to simulate the prepared abutments of a three-unit fixed dental prosthesis. A total of seventy five samples of interim fixed dental prostheses were prepared using autopolymerizing tooth colour acrylic resin. Unidirectional and woven forms of glass fibres (Stick and Stick Net), which were silane treated and untreated were used to reinforce the resin matrix. Fifteen samples were prepared for each group along with unreinforced group serving as control. The flexural strength was evaluated with universal testing machine. The means and standard deviations of flexural strength for different groups were 13.90 ± 2.96 (control), 61.58 ± 5.26 (unidirectional fibres), 30.89 ± 3.60 (woven fibres), 112.05 ± 5.51 (silane treated unidirectional fibres) and 73.85 ± 4.10 (silane treated woven fibres) respectively. The mean flexural strength of silane treated unidirectional fibres (112.05 MPa) was highest and statistically highly significant (P fibres is an effective method of reinforcing interim fixed restorations made of PMMA resins.

  18. Performance and economic evaluation of the seahorse natural gas hot water heater conversion at Fort Stewart. Interim report, 1994 Summer

    Energy Technology Data Exchange (ETDEWEB)

    Winiarski, D.W.

    1995-01-01

    The federal government is the largest single energy consumer in the United States cost valued at nearly $10 billion annually. The US Department of Energy`s (DOE) Federal Energy Management Program (FEMP) supports efforts to reduce energy use and associated expenses in the federal sector. One such effort, the New Technology Demonstration Program (NTDP), seeks to evaluate new energy-saving US technologies and secure their more timely adoption by the US government. Pacific Northwest Laboratory (PNL) is one of four DOE laboratories that participate in the New Technologies Demonstration Program, providing technical expertise and equipment to evaluate new, energy-saving technologies being studied under that program. This interim report provides the results of a field evaluation that PNL conducted for DOE/FEMP and the US Department of Defense (DoD) Strategic Environmental Research and Development Program (SERDP) to examine the performance of a candidate energy-saving technology-a hot water heater conversion system to convert electrically heated hot water tanks to natural gas fuel. The unit was installed at a single residence at Fort Stewart, a US Army base in Georgia, and the performance was monitored under the NTDP. Participating in this effort under a Cooperative Research and Development Agreement (CRADA) were Gas Fired Products, developers of the technology; the Public Service Company of North Carolina; Atlanta Gas Light Company; the Army Corps of Engineers; Fort Stewart; and Pacific Northwest Laboratory.

  19. Quantitative analyses at baseline and interim PET evaluation for response assessment and outcome definition in patients with malignant pleural mesothelioma

    Energy Technology Data Exchange (ETDEWEB)

    Lopci, Egesta; Chiti, Arturo [Humanitas Research Hospital, Nuclear Medicine Department, Rozzano, Milan (Italy); Zucali, Paolo Andrea; Perrino, Matteo; Gianoncelli, Letizia; Lorenzi, Elena; Gemelli, Maria; Santoro, Armando [Humanitas Research Hospital, Oncology, Rozzano (Italy); Ceresoli, Giovanni Luca [Humanitas Gavazzeni, Oncology, Bergamo (Italy); Giordano, Laura [Humanitas Research Hospital, Biostatistics, Rozzano (Italy)

    2015-04-01

    Quantitative analyses on FDG PET for response assessment are increasingly used in clinical studies, particularly with respect to tumours in which radiological assessment is challenging and complete metabolic response is rarely achieved after treatment. A typical example is malignant pleural mesothelioma (MPM), an aggressive tumour originating from mesothelial cells of the pleura. We present our results concerning the use of semiquantitative and quantitative parameters, evaluated at the baseline and interim PET examinations, for the prediction of treatment response and disease outcome in patients with MPM. We retrospectively analysed data derived from 131 patients (88 men, 43 women; mean age 66 years) with MPM who were referred to our institution for treatment between May 2004 and July 2013. Patients were investigated using FDG PET at baseline and after two cycles of pemetrexed-based chemotherapy. Responses were determined using modified RECIST criteria based on the best CT response after treatment. Disease control rate, progression-free survival (PFS) and overall survival (OS) were calculated for the whole population and were correlated with semiquantitative and quantitative parameters evaluated at the baseline and interim PET examinations; these included SUV{sub max}, total lesion glycolysis (TLG), percentage change in SUV{sub max} (ΔSUV{sub max}) and percentage change in TLG (ΔTLG). Disease control was achieved in 84.7 % of the patients, and median PFS and OS for the entire cohort were 7.2 and 14.3 months, respectively. The log-rank test showed a statistically significant difference in PFS between patients with radiological progression and those with partial response (PR) or stable disease (SD) (1.8 vs. 8.6 months, p < 0.001). Baseline SUV{sub max} and TLG showed a statistically significant correlation with PFS and OS (p < 0.001). In the entire population, both ΔSUV{sub max} and ΔTLG were correlated with disease control based on best CT response (p < 0

  20. Evaluation of Hose in Hose Transfer Line Service Life for Hanford's Interim Stabilization Program

    Energy Technology Data Exchange (ETDEWEB)

    TORRES, T.D.

    2000-08-24

    RPP-6153, Engineering Task Plan for Hose-in-Hose Transfer System for the Interim Stabilization Program, defines the programmatic goals, functional requirements, and technical criteria for the development and subsequent installation of transfer line equipment to support Hanford's Interim Stabilization Program. RPP-6028, Specification for Hose in Hose Transfer Lines for Hanford's Interim Stabilization Program, has been issued to define the specific requirements for the design, manufacture, and verification of transfer line assemblies for specific waste transfer applications. Included in RPP-6028 are tables defining the chemical constituents of concern to which transfer lines will be exposed. Current Interim Stabilization Program planning forecasts that the at-grade transfer lines will be required to convey pumpable waste for as much as three years after commissioning. Prudent engineering dictates that the equipment placed in service have a working life in excess of this forecasted time period, with some margin to allow for future adjustments to the planned schedule. This document evaluates the effective service life of the Hose-in-Hose Transfer Lines, based on information submitted by the manufacturer and published literature. The effective service life of transfer line assemblies is a function of several factors. Foremost among these are process fluid characteristics, ambient environmental conditions, and the manufacturer's stated shelf life. This evaluation examines the manufacturer's certification of shelf life, the manufacturer's certifications of chemical compatibility with waste, and published literature on the effects of exposure to ionizing radiation on the mechanical properties of elastomeric materials to evaluate transfer line service life.

  1. AIRS high-resolution stratospheric temperature retrievals evaluated with operational Level-2 data and ERA-Interim

    Science.gov (United States)

    Meyer, Catrin I.; Hoffmann, Lars

    2015-04-01

    The Atmospheric InfraRed Sounder (AIRS) aboard NASA's Aqua satellite provides stratospheric temperature observations for a variety of scientific tasks. However, the horizontal resolution of the operational temperature retrievals is generally not sufficient for studies of gravity waves. The retrieval discussed here provides stratospheric temperature profiles for each individual AIRS footprint and therefore has nine times better horizontal sampling than the operational data. The retrieval configuration is optimized so that the results provide a trade-off between spatial resolution and retrieval noise which is considered optimal for gravity wave analysis. Here the quality of the high-resolution data is assessed by comparing a nine-year record (2003 - 2011) of stratospheric temperatures with results from the AIRS operational Level-2 data and the ERA-Interim meteorological reanalysis. Due to the large amount of data we performed a statistical comparison of the high-resolution retrieval and reference data sets based on zonal averages and time-series. The temperature data sets are split into day and night, because the AIRS high-resolution retrieval uses different configurations for day- and night-time conditions to cope with non-LTE effects. The temperature data are averaged on a latitudinal grid with a resolution of one degree. The zonal averages are calculated on a daily basis and show significant day-to-day variability. To further summarize the data we calculated monthly averages from the daily averaged data and also computed zonal means. Additionally, the standard deviation of the three data sets was computed. The comparisons show that the high-resolution temperature data are in good agreement with the reference data sets. The bias in the zonal averages is mostly within ± 2 K and reaches a maximum of 7 K to ERA-Interim and 4 K to the AIRS operational data at the stratopause, which is related to the different resolutions of the data sets. Variability is nearly the

  2. Evaluation of internal fit of interim crown fabricated with CAD/CAM milling and 3D printing system.

    Science.gov (United States)

    Lee, Wan-Sun; Lee, Du-Hyeong; Lee, Kyu-Bok

    2017-08-01

    This study is to evaluate the internal fit of the crown manufactured by CAD/CAM milling method and 3D printing method. The master model was fabricated with stainless steel by using CNC machine and the work model was created from the vinyl-polysiloxane impression. After scanning the working model, the design software is used to design the crown. The saved STL file is used on the CAD/CAM milling method and two types of 3D printing method to produce 10 interim crowns per group. Internal discrepancy measurement uses the silicon replica method and the measured data are analyzed with One-way ANOVA to verify the statistic significance. The discrepancy means (standard deviation) of the 3 groups are 171.6 (97.4) µm for the crown manufactured by the milling system and 149.1 (65.9) and 91.1 (36.4) µm, respectively, for the crowns manufactured with the two types of 3D printing system. There was a statistically significant difference and the 3D printing system group showed more outstanding value than the milling system group. The marginal and internal fit of the interim restoration has more outstanding 3D printing method than the CAD/CAM milling method. Therefore, the 3D printing method is considered as applicable for not only the interim restoration production, but also in the dental prosthesis production with a higher level of completion.

  3. Safety evaluation for the interim stabilization of Tank 241-C-103

    Energy Technology Data Exchange (ETDEWEB)

    Geschke, G.R.

    1995-03-01

    This document provides the basis for interim stabilization of tank 241-C-103. The document covers the removal of the organic liquid layer and the aqueous supernatant from tank 241-C-103. Hazards are identified, consequences are calculated and controls to mitigate or prevent potential accidents are developed.

  4. PROJECT W-551 INTERIM PRETREATMENT SYSTEM TECHNOLOGY SELECTION SUMMARY DECISION REPORT AND RECOMMENDATION

    Energy Technology Data Exchange (ETDEWEB)

    CONRAD EA

    2008-08-12

    This report provides the conclusions of the tank farm interim pretreatment technology decision process. It documents the methodology, data, and results of the selection of cross-flow filtration and ion exchange technologies for implementation in project W-551, Interim Pretreatment System. This selection resulted from the evaluation of specific scope criteria using quantitative and qualitative analyses, group workshops, and technical expert personnel.

  5. Interim results of the study of control room crew staffing for advanced passive reactor plants

    Energy Technology Data Exchange (ETDEWEB)

    Hallbert, B.P.; Sebok, A.; Haugset, K. [OECD Halden Reactor Project (Norway)

    1996-03-01

    Differences in the ways in which vendors expect the operations staff to interact with advanced passive plants by vendors have led to a need for reconsideration of the minimum shift staffing requirements of licensed Reactor Operators and Senior Reactor Operators contained in current federal regulations (i.e., 10 CFR 50.54(m)). A research project is being carried out to evaluate the impact(s) of advanced passive plant design and staffing of control room crews on operator and team performance. The purpose of the project is to contribute to the understanding of potential safety issues and provide data to support the development of design review guidance. Two factors are being evaluated across a range of plant operating conditions: control room crew staffing; and characteristics of the operating facility itself, whether it employs conventional or advanced, passive features. This paper presents the results of the first phase of the study conducted at the Loviisa nuclear power station earlier this year. Loviisa served as the conventional plant in this study. Data collection from four crews were collected from a series of design basis scenarios, each crew serving in either a normal or minimum staffing configuration. Results of data analyses show that crews participating in the minimum shift staffing configuration experienced significantly higher workload, had lower situation awareness, demonstrated significantly less effective team performance, and performed more poorly as a crew than the crews participating in the normal shift staffing configuration. The baseline data on crew configurations from the conventional plant setting will be compared with similar data to be collected from the advanced plant setting, and a report prepared providing the results of the entire study.

  6. Evaluation of internal fit of interim crown fabricated with CAD/CAM milling and 3D printing system

    OpenAIRE

    Lee, Wan-Sun; Lee, Du-Hyeong; Lee, Kyu-Bok

    2017-01-01

    PURPOSE This study is to evaluate the internal fit of the crown manufactured by CAD/CAM milling method and 3D printing method. MATERIALS AND METHODS The master model was fabricated with stainless steel by using CNC machine and the work model was created from the vinyl-polysiloxane impression. After scanning the working model, the design software is used to design the crown. The saved STL file is used on the CAD/CAM milling method and two types of 3D printing method to produce 10 interim crown...

  7. Evaluation of higher distribution and/or utilization voltages. Fourth interim report (August 1980): assessment of optimum distribution configuration

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    This interim report provides documentation on the fourth task, Assessment of Optimum Distribution Configuration, of DOE Contract No. ET-78-C-01-2866, Evaluation of Higher Distribution and/or Utilization Voltages. The work performed under this task includes the development of a computer model for assessment of life cycle costs for the distribution and utilization systems, the development of an optimization algorithm to enable distribution system configuration optimization and a net energy analysis to determine potential net energy savings. Input data for this task derive from Task 3. The major output of this task is a documented computer code.

  8. Spinal cord stimulation or prostacyclin in unrevascularizable arteriopathy of lower limbs (SPINAL study: interim analysis results

    Directory of Open Access Journals (Sweden)

    Pedrini L

    2014-04-01

    Full Text Available Luciano Pedrini,1 Maria Sandra Ballestrazzi,1 Fabio Chierichetti,2 Luigi Comandatore,3 Filippo Magnoni,1 Reinhold Perkmann,4 Tommaso Castrucci,5 Domenico Palombo6On behalf of the SPINAL Study Group1Operative Unit of Vascular Surgery, Maggiore Hospital of Bologna, Bologna, Italy; 2Operative Unit of Vascular Surgery, Circle Hospital of Busto Arsizio, Busto Arsizio, Italy; 3Operative Unit of Vascular Surgery, AEO Morelli of Sondalo, Sondalo, Italy; 4Operative Unit of Vascular and Thoracic Surgery, Hospital of Bolzano, Bolzano, Italy; 5Operative Unit of Vascular Surgery of Sant'Eugenio Hospital, Rome, Italy; 6Operative Unit of Vascular and Endovascular Surgery, IRCCS San Martino, Genoa, ItalyObjective: The aim of this study was to compare the clinical efficacy and the safety of spinal cord stimulation (SCS plus medical treatment versus iloprost plus medical treatment in patients with severe unrevascularizable ischemia of the lower limbs due to atherosclerotic disease of the limbs and to identify predictive parameters for a positive outcome of SCS.Methods: A multicenter randomized controlled trial (RCT with central randomization and core laboratory evaluation of angiography, subdivided into two treatment arms (SCS and iloprost and two subgroups (rest pain and ulcer/gangrene. After the 15-day clinical efficacy evaluation, responder patients continued follow-up in their arm, while nonresponders could change arms or decline participation. The primary endpoint was 1-year limb salvage. Principal secondary endpoints were: survival rate; minor amputations and stump healing; ulcer healing; pain relief and analgesic intake; and predictive criteria for SCS treatment.Results: The trial was stopped at 35.6% of the expected sample due to low accrual rate. Fifty-two patients (55 legs entered the study. At the 15-day efficacy evaluation, responders (reduced pain, no increase of ulcer area comprised 74% of the SCS arm and 26% of the iloprost arm, (P=0.003. Nine

  9. Randomized Clinical Trial Comparing Proton Beam Radiation Therapy with Transarterial Chemoembolization for Hepatocellular Carcinoma: Results of an Interim Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bush, David A., E-mail: dbush@llu.edu [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Smith, Jason C. [Department of Diagnostic Radiology, Loma Linda University Medical Center, Loma Linda, California (United States); Slater, Jerry D. [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Volk, Michael L. [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States); Reeves, Mark E. [VA Loma Linda Health Care System, Loma Linda, California (United States); Cheng, Jason [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States); Grove, Roger [Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California (United States); Vera, Michael E. de [Transplantation Institute and Liver Center, Loma Linda University Medical Center, Loma Linda, California (United States)

    2016-05-01

    Purpose: To describe results of a planned interim analysis of a prospective, randomized clinical trial developed to compare treatment outcomes among patients with newly diagnosed hepatocellular carcinoma (HCC). Methods and Materials: Eligible subjects had either clinical or pathologic diagnosis of HCC and met either Milan or San Francisco transplant criteria. Patients were randomly assigned to transarterial chemoembolization (TACE) or to proton beam radiation therapy. Patients randomized to TACE received at least 1 TACE with additional TACE for persistent disease. Proton beam radiation therapy was delivered to all areas of gross disease to a total dose of 70.2 Gy in 15 daily fractions over 3 weeks. The primary endpoint was progression-free survival, with secondary endpoints of overall survival, local tumor control, and treatment-related toxicities as represented by posttreatment days of hospitalization. Results: At the time of this analysis 69 subjects were available for analysis. Of these, 36 were randomized to TACE and 33 to proton. Total days of hospitalization within 30 days of TACE/proton was 166 and 24 days, respectively (P<.001). Ten TACE and 12 proton patients underwent liver transplantation after treatment. Viable tumor identified in the explanted livers after TACE/proton averaged 2.4 and 0.9 cm, respectively. Pathologic complete response after TACE/proton was 10%/25% (P=.38). The 2-year overall survival for all patients was 59%, with no difference between treatment groups. Median survival time was 30 months (95% confidence interval 20.7-39.3 months). There was a trend toward improved 2-year local tumor control (88% vs 45%, P=.06) and progression-free survival (48% vs 31%, P=.06) favoring the proton beam treatment group. Conclusions: This interim analysis indicates similar overall survival rates for proton beam radiation therapy and TACE. There is a trend toward improved local tumor control and progression-free survival with proton beam. There are

  10. Extraction, -scrub, -strip test results from the interim salt disposition program macrobatch 10 tank 21H qualification samples

    Energy Technology Data Exchange (ETDEWEB)

    Peters, T. B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-06-26

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 10 for the Interim Salt Disposition Program (ISDP). The Salt Batch 10 characterization results were previously reported.ii,iii An Extraction, -Scrub, -Strip (ESS) test was performed to determine cesium distribution ratios (D(Cs)) and cesium concentration in the strip effluent (SE) and decontaminated salt solution (DSS) streams; this data will be used by Tank Farm Engineering to project a cesium decontamination factor (DF). This test used actual Tank 21H material, and a sample of the NGS Blend solvent currently being used at the Modular Caustic-Side Solvent Extraction Unit (MCU). The ESS test showed acceptable performance with an extraction D(Cs) value of 110. This value is consistent with results from previous salt batch ESS tests using similar solvent formulations. This is better than the predicted value of 39.8 from a recently created D(Cs) model.

  11. Interim Report on Heuristics about Inspection Parameters: Updates to Heuristics Resulting from Refinement on Projects

    Science.gov (United States)

    Shull, Forrest; Seaman, Carolyn; Feldman, Raimund; Haingaertner, Ralf; Regardie, Myrna

    2008-01-01

    In 2008, we have continued analyzing the inspection data in an effort to better understand the applicability and effect of the inspection heuristics on inspection outcomes. Our research goals during this period are: 1. Investigate the effect of anomalies in the dataset (e.g. the very large meeting length values for some inspections) on our results 2. Investigate the effect of the heuristics on other inspection outcome variables (e.g. effort) 3. Investigate whether the recommended ranges can be modified to give inspection planners more flexibility without sacrificing effectiveness 4. Investigate possible refinements or modifications to the heuristics for specific subdomains (partitioned, e.g., by size, domain, or Center) This memo reports our results to date towards addressing these goals. In the next section, the first goal is addressed by describing the types of anomalies we have found in our dataset, how we have addressed them, and the effect of these changes on our previously reported results. In the following section, on "methodology", we describe the analyses we have conducted to address the other three goals and the results of these analyses are described in the "results" section. Finally, we conclude with future plans for continuing our investigation.

  12. An interim assessment of the results of day-treatment in nursing homes

    NARCIS (Netherlands)

    Nies, H. L.G.R.

    1986-01-01

    Day-treatment has developed very rapidly in Dutch nursing homes. This development was due to several unproved positive expectations concerning the therapeutical results, the effects for relatives and caregivers at home and the substitutional effects of day-treatment. In this article these

  13. Interim report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1985-06-01

    This Interim Report summarizes the research and development activities of the Superconducting Super Collider project carried out from the completion of the Reference Designs Study (May 1984) to June 1985. It was prepared by the SSC Central Design Group in draft form on the occasion of the DOE Annual Review, June 19--21, 1985. Now largely organized by CDG Divisions, the bulk of each chapter documents the progress and accomplishments to date, while the final section(s) describe plans for future work. Chapter 1, Introduction, provides a basic brief description of the SSC, its physics justification, its origins, and the R&D organization set up to carry out the work. Chapter 2 gives a summary of the main results of the R&D program, the tasks assigned to the four magnet R&D centers, and an overview of the future plans. The reader wishing a quick look at the SSC Phase I effort can skim Chapter 1 and read Chapter 2. Subsequent chapters discuss in more detail the activities on accelerator physics, accelerator systems, magnets and cryostats, injector, detector R&D, conventional facilities, and project planning and management. The magnet chapter (5) documents in text and photographs the impressive progress in successful construction of many model magnets, the development of cryostats with low heat leaks, and the improvement in current-carrying capacity of superconducting strand. Chapter 9 contains the budgets and schedules of the COG Divisions, the overall R&D program, including the laboratories, and also preliminary projections for construction. Appendices provide information on the various panels, task forces and workshops held by the CDG in FY 1985, a bibliography of COG and Laboratory reports on SSC and SSC-related work, and on private industrial involvement in the project.

  14. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands: aims, design and interim results

    OpenAIRE

    Silva, L.M.; Kuipers, I.M.; Heuvel, F. van den; Mendes, R.; Berger, R.M.; Beynum, I.M. van; Rozendaal, L.; Rammeloo, L.A.; Iperen, G.G. van; Schokking, M.; Frerich, S.; Blom, N.A.; Breur, J.M.; Helbing, W.A.

    2016-01-01

    textabstractObjective Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with heart diseases. This paper presents the aims, design and interim results of the KinCor project. Methods All children presenting at a Dutch university medical centre with a diagnosis of heart...

  15. Postoperative hypersensitivity in class I resin-based composite restorations in general practice: interim results.

    Science.gov (United States)

    Berkowitz, Gary S; Horowitz, Allan J; Curro, Fredrick A; Craig, Ronald G; Ship, Jonathan A; Vena, Donald; Thompson, Van P

    2009-01-01

    Posterior permanent teeth with carious lesions radiographically extending no further than halfway into dentin (N = 565) were restored by 38 dentists in a practice-based research network, using a resin-based composite. Preoperative and 1-, 4-, and 13-week posttreatment hypersensitivity was recorded with an 11-point visual analog scale that was completed anonymously by participants. The analyses determined whether any correlation or association existed among several variables, including degree of carious activity; cavity extent; application of antimicrobial or desensitizing agents; application of liner, dentin-bonding agent and resin-based composite employed; and composite placement method. Three results were fairly unexpected: Only 36% of lesions were ranked as caries-active, 31% of teeth had appreciable preoperative hypersensitivity, and 16% of teeth with no preoperative hypersensitivity had appreciable hypersensitivity at 1 week posttreatment. Preoperative hypersensitivity was correlated with lesion visibility on radiographs but not with dentin caries activity (ranked on opening enamel), preparation depth, or preparation volume. Accrual to the study continues, and conclusions regarding other relationships await 13-week results.

  16. Biofilm formation and control in a simulated spacecraft water system - Interim results

    Science.gov (United States)

    Schultz, John R.; Taylor, Robert D.; Flanagan, David T.; Gibbons, Randall E.; Brown, Harlan D.; Sauer, Richard L.

    1989-01-01

    The ability of iodine to control microbial contamination and biofilm formation in spacecraft water distribution systems is studied using two stainless steel water subsystems. One subsystem has an iodine level of 2.5 mg/L maintained by an iodinated ion-exchange resin. The other subsystem has no iodine added. Stainless steel coupons are removed from each system to monitor biofilm formation. Results from the first six months of operation indicate that 2.5 mg/L of iodine has limited the number of viable bacteria that can be recovered from the iodinated subsystem. Epifluorescence microscopy of the coupons taken from this subsystem, however, indicates some evidence of microbial colonization after 15 weeks of operation. Numerous bacteria have been continually removed from both the water samples and the coupons taken from the noniodinated subsystem after only 3 weeks of operation.

  17. Apathy Treatment in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.

    Science.gov (United States)

    Rea, Raffaele; Carotenuto, Anna; Traini, Enea; Fasanaro, Angiola Maria; Manzo, Valentino; Amenta, Francesco

    2015-01-01

    Apathy is a common symptom in Alzheimer's disease (AD), but no treatment has proven to be effective, although administration of cholinesterase inhibitors has been associated with moderate improvements in the short term. This study has compared apathy scores of patients included in "ASCOMALVA" trial treated for two years with donepezil plus a cholinergic precursor (choline alphoscerate), to those of patients receiving donepezil alone with the purpose of assessing if the availability of a higher amount of acetylcholine by combining precursor loading and inhibition of neurotransmitter breakdown would counter apathy in AD. Apathy was measured at baseline and 3, 6, 9, 12, 18, and 24 months using the apathy subtest of the Neuropsychiatric Inventory in 113 mild-moderate AD patients. Two matched groups were compared: group 1 (56 subjects) treated with donepezil plus choline alphoscerate and group 2 (57 subjects) treated with donepezil alone. Frontal functions were explored by the Frontal Assessment Battery (FAB) at baseline. Group 1 subjects showed, as a whole, a lower apathy score after 12 to 24 months. The caregiver distress was descreased after 6 to 24 months. Results were unrelated with cognitive scores measured by the MMSE and ADAS-cog test. Subjects with FAB in the normal range had significantly lower scores. The combination of donepezil with choline alphoscerate is more effective than donepezil alone in countering symptoms of apathy in AD. This suggests that the availability in brain of a higher amount of acetylcholine could affect apathy in AD subjects with spared executive functions.

  18. FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size

    Directory of Open Access Journals (Sweden)

    Helmut Kern

    2012-03-01

    Full Text Available Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32 and two groups in Bratislava: (n=19. All subjects were healthy and declared not to have any specific physical/disease problems. The two Vienna groups of seniors exercised for 10 weeks with two different types of training (leg press at the hospital or home-based functional electrical stimulation, h-b FES. Demografic data (age, height and weight were recorded before and after the training period and before and after the training period the patients were submitted to mobility functional analyses and muscle biopsies. The mobility functional analyses were: 1. gait speed (10m test fastest speed, in m/s; 2. time which the subject needed to rise from a chair for five times (5x Chair-Rise, in s; 3. Timed –Up-Go- Test, in s; 4. Stair-Test, in s; 5. isometric measurement of quadriceps force (Torque/kg, in Nm/kg; and 6. Dynamic Balance in mm. Preliminary analyses of muscle biopsies from quadriceps in some of the Vienna and Bratislava patients present morphometric results consistent with their functional behaviors. The statistically significant improvements in functional testings here reported demonstrates the effectiveness of h-b FES, and strongly support h-b FES, as a safe home-based method to improve contractility and performances of ageing muscles.

  19. Safety and Effectiveness of Natalizumab: First Report of Interim Results of Post-Marketing Surveillance in Japan.

    Science.gov (United States)

    Saida, Takahiko; Yokoyama, Kazumasa; Sato, Ryusuke; Makioka, Haruki; Iizuka, Yukihiko; Hase, Masakazu; Ling, Yan; Torii, Shinichi

    2017-12-01

    Natalizumab, a humanized anti-α4 integrin monoclonal antibody, received marketing approval in Japan in 2014 for the treatment of multiple sclerosis (MS). Because the previous large-scale clinical trials of natalizumab were mainly conducted in Europe and North American countries, and data in patients with MS from Japan were limited, we conducted an all-case post-marketing surveillance of natalizumab-treated MS patients from Japan to investigate the safety and effectiveness of natalizumab in a real-world clinical setting in Japan. Here, we report the results of an interim analysis. During the observation period of 2 years, all patients who were treated with natalizumab subsequent to its approval in Japan were followed. The effectiveness of natalizumab was assessed by examining the changes in expanded disability status scale (EDSS) score and annualized relapse rate (ARR) from baseline. Safety was assessed by analyzing the incidence of adverse drug reactions (ADRs). The safety analysis included 106 patients (mean age 39.3 years; women 62.3%) whose data were collected until the data lock point (February 7, 2016). The effectiveness analysis included 75 patients. The majority of patients had relapsing-remitting MS (93/106 patients; 87.7%). The mean length of treatment exposure in the present study was 6.6 months. During the 2-year observation period, no significant change in the EDSS was observed, while the ARR decreased significantly from baseline (72.9% reduction, p = 0.001). ADRs and serious ADRs were observed in 11.3% and 3.8% of patients, respectively; however, no new safety concerns were detected. No patient had progressive multifocal leukoencephalopathy (PML) during the present study period. The safety and effectiveness of natalizumab were confirmed in Japanese patients with MS in clinical practice. Nevertheless, potential risks including PML require continuous, careful observation. Biogen Japan Ltd (Tokyo, Japan).

  20. Deep Vadose Zone Treatability Test for the Hanford Central Plateau. Interim Post-Desiccation Monitoring Results, Fiscal Year 2015

    Energy Technology Data Exchange (ETDEWEB)

    Truex, Michael J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Strickland, Christopher E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oostrom, Martinus [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnson, Christian D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tartakovsky, Guzel D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnson, Timothy C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Clayton, Ray E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chronister, Glen B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-09-01

    A field test of desiccation is being conducted as an element of the Deep Vadose Zone Treatability Test Program. The active desiccation portion of the test has been completed. Monitoring data have been collected at the field test site during the post-desiccation period and are reported herein. This is an interim data summary report that includes about 4 years of post-desiccation monitoring data. The DOE field test plan proscribes a total of 5 years of post-desiccation monitoring.

  1. Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL

    Directory of Open Access Journals (Sweden)

    E. N. Parovichnikova

    2015-01-01

    Full Text Available An interim analysis of long-term treatment results for 202 patients with acute lymphoblastic leukemia (ALL, aged 15–60 years, received therapy according protocol ALL-2009 was shown. The basic principle of ALL-2009 was non-aggressive, but continued cytostatic exposure, as well as the reproducibility in a regional hematology centers. Long-term treatment results of ALL-2009 are 2 times higher than the previously obtained in adult ALL patients within the Russian clinical multicenter studies of adult ALL. The 5‑year overall survival of patients younger than 30 years was 73.6 %, relapse-free survival (RFS – 71.5 %, compared with 52.7 % and 61.8 % in patients aged 30 years and older, respectively. In patients with B-precursor ALL with normal karyotype of blast cells significantly higher 5‑year RFS (82.1 % compared to patients with abnormal karyotype (58.8 % was registered. For T-ALL cytogenetic characteristics of blast cells had no prognostic significance. For patients with T-ALL important to perform autologous stem cell transplantation as a later consolidation, as this significantly reducerelapse rate (from 33 to 0 %.

  2. Evaluation of groundwater flow and transport at the Shoal underground nuclear test: An interim report

    Energy Technology Data Exchange (ETDEWEB)

    Pohll, G.; Chapman, J.; Hassan, A.; Papelis, C.; Andricevic, R.; Shirley, C.

    1998-07-01

    Since 1962, all United States nuclear tests have been conducted underground. A consequence of this testing has been the deposition of large amounts of radioactive materials in the subsurface, sometimes in direct contact with groundwater. The majority of this testing occurred on the Nevada Test Site, but a limited number of experiments were conducted in other locations. One of these is the subject of this report, the Project Shoal Area (PSA), located about 50 km southeast of Fallon, Nevada. The Shoal test consisted of a 12-kiloton-yield nuclear detonation which occurred on October 26, 1963. Project Shoal was part of studies to enhance seismic detection of underground nuclear tests, in particular, in active earthquake areas. Characterization of groundwater contamination at the Project Shoal Area is being conducted by the US Department of Energy (DOE) under the Federal Facility Agreement and Consent Order (FFACO) with the State of Nevada Department of Environmental Protection and the US Department of Defense (DOD). This order prescribes a Corrective Action Strategy (Appendix VI), which, as applied to underground nuclear tests, involves preparing a Corrective Action Investigation Plan (CAIP), Corrective Action Decision Document (CADD), Corrective Action Plan, and Closure Report. The scope of the CAIP is flow and transport modeling to establish contaminant boundaries that are protective of human health and the environment. This interim report describes the current status of the flow and transport modeling for the PSA.

  3. Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: Interim results of a prospective cohort study

    Directory of Open Access Journals (Sweden)

    Schutte Del H

    2008-02-01

    Full Text Available Abstract Background We sought to examine the detection rate of cancer cells in peripheral blood (PBL and in bone marrow (BM using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. Methods Patients with T1-T3 primary breast cancer were enrolled into a prospective, multi-institutional cohort study. In this interim analysis 215 PBL and 177 BM samples were analyzed by multimarker, real-time RT-PCR analysis designed to detect circulating and disseminated breast cancer cells. Results At a threshold of three standard deviations from the mean expression level of normal controls, 63% (136/215 of PBL and 11% (19/177 of BM samples were positive for at least one cancer-associated marker. Marker positivity in PBL demonstrated a statistically significant association with grade II-III (vs. grade I; p = 0.0083. Overexpression of the mammaglobin (mam gene alone had a statistically significant association with high tumor grade (p = 0.0315, and showed a trend towards ER-negative tumors and a high risk category. There was no association between marker positivity in PBL and the pathologic (H&E and/or molecular (RT-PCR status of the axillary lymph nodes (ALN. Conclusion This study suggests that molecular detection of circulating cancer cells in PBL detected by RT-PCR is associated with high tumor grade and specifically that overexpression of the mam gene in PBL may be a poor prognostic indicator. There was no statistically significant association between overexpression of cancer-associated genes in PBL and ALN status, supporting the concept of two potentially separate metastatic pathways.

  4. Transuranic storage and assay facility interim safety basis

    Energy Technology Data Exchange (ETDEWEB)

    Porten, D.R., Fluor Daniel Hanford

    1997-02-12

    The Transuranic Waste Storage and Assay Facility (TRUSAF) Interim Safety Basis document provides the authorization basis for the interim operation and restriction on interim operations for the TRUSAF. The TRUSAF ISB demonstrates that the TRUSAF can be operated safely, protecting the workers, the public, and the environment. The previous safety analysis document TRUSAF Hazards Identification and Evaluation (WHC 1987) is superseded by this document.

  5. Evaluation of tuff as a medium for a nuclear waste repository: interim status report on the properties of tuff

    Energy Technology Data Exchange (ETDEWEB)

    Johnstone, J.K.; Wolfsberg, K. (eds.)

    1980-07-01

    This report is the second in a series of summary briefings to the National Academy of Science`s (NAS) Committee on Radioactive Waste Management dealing with feasibility of disposal of heat-producing radioactive waste in silicic tuff. The interim status of studies of tuff properties determined on samples obtained from Yucca Mountain and Rainier Mesa (G-tunnel) located on the Nevada Test Site (NTS) are discussed. In particular, progress is described on resolving issues identified during the first briefing to the NAS which include behavior of water in tuff when heated, the effect of the presence or absence of water and joints on the thermal/physical properties of tuff and the detailed/complex sorptive properties of highly altered and unaltered tuff. Initial correlations of thermal/physical and sorptive properties with the highly variable porosity and mineralogy are described. Three in-situ, at-depth field experiments, one nearly completed and two just getting underway are described. In particular, the current status of mineralogy and petrology, geochemistry, thermal and mechanical, radiation effects and water behavior studies are described. The goals and initial results of a Mine Design Working Group are discussed. Regional factors such as seismicity, volcanism and hydrology are not discussed.

  6. Evaluation and Assessment Processes in Nebraska Public Schools. A Staff Report. Education Interim Study LR 181.

    Science.gov (United States)

    Nebraska Legislative Council, Lincoln. Legislative Research Div.

    During the spring of 1987, the National Conference of State Legislatures awarded the Nebraska Legislature a cost-sharing award to study local school evaluation processes. Embodied in Legislative Resolution 181, which has the purpose of studying school evaluation procedures, the study attempts to provide legislators, educators, local school…

  7. Results Evaluation in Reduction Rhinoplasty

    Directory of Open Access Journals (Sweden)

    Arima, Lisandra Megumi

    2011-01-01

    Full Text Available Introduction: Final results evaluation after rhinoplasty is a not a topic widely studied from the patient's viewpoint. Objective:Evaluate the satisfaction of the patients submitted to reduction rhinoplasty, from the questionnaire Rhinoplasty Outcomes Evaluation (ROE. Method: Longitudinal study, retrospective cut type, of the preoperative and postoperative satisfaction. The sample was composed by 28 patients who were submitted to rhinoplasty and answered the ROE questionnaire. Three variables were obtained: satisfaction note that the patient had with his/her image before the surgery; note of satisfaction with the current appearance; the difference of the average satisfaction notes between postoperative and preoperative approaches. Results: The postoperative note was higher than the preoperative in all patients. We noticed a difference between the average of the postoperative and preoperative of 48.3 (p75 considered to be an excellent outcome (67.9%. Conclusions: The ROE questionnaire is a helpful tool to show the satisfaction of the patient submitted to reduction rhinoplasty. About 92% of the patients submitted to reduction rhinoplasty consider the postoperative result to be good or excellent.

  8. Evaluation of the performance, cost-effectiveness, and timing of various preventive maintenances : interim report.

    Science.gov (United States)

    2010-10-01

    This research study evaluated the performance of various pavement preservation treatments over time and under different : environmental conditions to quantify the economics of each treatment type. There are three primary techniques utilized in Colora...

  9. Plug-In Hybrid Electric Vehicle Value Proposition Study: Interim Report: Phase I Scenario Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Sikes, Karen R [ORNL; Markel, Lawrence C [ORNL; Hadley, Stanton W [ORNL; Hinds, Shaun [Sentech, Inc.; DeVault, Robert C [ORNL

    2009-01-01

    Plug-in hybrid electric vehicles (PHEVs) offer significant improvements in fuel economy, convenient low-cost recharging capabilities, potential environmental benefits, and decreased reliance on imported petroleum. However, the cost associated with new components (e.g., advanced batteries) to be introduced in these vehicles will likely result in a price premium to the consumer. This study aims to overcome this market barrier by identifying and evaluating value propositions that will increase the qualitative value and/or decrease the overall cost of ownership relative to the competing conventional vehicles and hybrid electric vehicles (HEVs) of 2030 During this initial phase of this study, business scenarios were developed based on economic advantages that either increase the consumer value or reduce the consumer cost of PHEVs to assure a sustainable market that can thrive without the aid of state and Federal incentives or subsidies. Once the characteristics of a thriving PHEV market have been defined for this timeframe, market introduction steps, such as supportive policies, regulations and temporary incentives, needed to reach this level of sustainability will be determined. PHEVs have gained interest over the past decade for several reasons, including their high fuel economy, convenient low-cost recharging capabilities, potential environmental benefits and reduced use of imported petroleum, potentially contributing to President Bush's goal of a 20% reduction in gasoline use in ten years, or 'Twenty in Ten'. PHEVs and energy storage from advanced batteries have also been suggested as enabling technologies to improve the reliability and efficiency of the electric power grid. However, PHEVs will likely cost significantly more to purchase than conventional or other hybrid electric vehicles (HEVs), in large part because of the cost of batteries. Despite the potential long-term savings to consumers and value to stakeholders, the initial cost of PHEVs

  10. Evaluation of Shear Strength Threshold of Concern for Retrieval of Interim-Stored K-Basin Sludge in the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Onishi, Yasuo; Yokuda, Satoru T.; Schmidt, Andrew J.

    2010-11-01

    K-Basin sludge will be recovered into the Sludge Transport and Storage Containers (STSCs) and will be stored in the T Plant for interim storage (at least 10 years). Long-term sludge storage tests conducted by Pacific Northwest National Laboratory show that high uranium content K Basin sludge can self-cement and form a strong sludge with a bulk shear strength of up to 65 kPa. Some of this sludge has "paste" and "chunks" with shear strengths of approximately 3~5 kPa and 380 ~ 770 kPa, respectively. High uranium content sludge samples subjected to hydrothermal testing (e.g., 185°C, 10 h) have been observed to form agglomerates with a shear strength up to 170 kPa. After interim storage at T Plant, the sludge in the STSCs will be mobilized by water jets impinging the sludge. The objective of the evaluation was to determine the range of sludge shear strength for which there is high confidence that a water-jet retrieval system can mobilize stored K-Basin sludge from STSCs. The shear strength at which the sludge can be retrieved is defined as the "shear strength threshold of concern." If the sludge shear strength is greater than the value of the shear strength threshold of concern, a water-jet retrieval system will be unlikely to mobilize the sludge up to the container’s walls. The shear strength threshold of concern can be compared with the range of possible shear strengths of K-Basin stored sludge to determine if the current post interim-storage, water-jet retrieval method is adequate. Fourteen effective cleaning radius (ECR) models were reviewed, and their validity was examined by applying them to Hanford 241-SY-101 and 241-AZ-101 Tanks to reproduce the measured ECR produced by the mixer pumps. The validation test identified that the Powell-3 and Crowe-2 ECR models are more accurate than other ECR models reviewed. These ECR models were used to address a question as to whether the effective cleaning radius of a water jet is sufficient or if it can be readily expanded

  11. Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection - United States, October 2017.

    Science.gov (United States)

    Adebanjo, Tolulope; Godfred-Cato, Shana; Viens, Laura; Fischer, Marc; Staples, J Erin; Kuhnert-Tallman, Wendi; Walke, Henry; Oduyebo, Titilope; Polen, Kara; Peacock, Georgina; Meaney-Delman, Dana; Honein, Margaret A; Rasmussen, Sonja A; Moore, Cynthia A

    2017-10-20

    CDC has updated its interim guidance for U.S. health care providers caring for infants with possible congenital Zika virus infection (1) in response to recently published updated guidance for health care providers caring for pregnant women with possible Zika virus exposure (2), unknown sensitivity and specificity of currently available diagnostic tests for congenital Zika virus infection, and recognition of additional clinical findings associated with congenital Zika virus infection. All infants born to mothers with possible Zika virus exposure* during pregnancy should receive a standard evaluation at birth and at each subsequent well-child visit including a comprehensive physical examination, age-appropriate vision screening and developmental monitoring and screening using validated tools (3-5), and newborn hearing screen at birth, preferably using auditory brainstem response (ABR) methodology (6). Specific guidance for laboratory testing and clinical evaluation are provided for three clinical scenarios in the setting of possible maternal Zika virus exposure: 1) infants with clinical findings consistent with congenital Zika syndrome regardless of maternal testing results, 2) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers with laboratory evidence of possible Zika virus infection, † and 3) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers without laboratory evidence of possible Zika virus infection. Infants in the first two scenarios should receive further testing and evaluation for Zika virus, whereas for the third group, further testing and clinical evaluation for Zika virus are not recommended. Health care providers should remain alert for abnormal findings (e.g., postnatal-onset microcephaly and eye abnormalities without microcephaly) in infants with possible congenital Zika virus exposure without apparent abnormalities at birth.

  12. A selective laser sintering prototype guide used to fabricate immediate interim fixed complete arch prostheses in flapless dental implant surgery: Technique description and clinical results.

    Science.gov (United States)

    Di Giacomo, Giovanni de A P; Cury, Patricia R; da Silva, Airton M; da Silva, Jorge V L; Ajzen, Sergio A

    2016-12-01

    Extensive occlusal adjustments and misfit of the prosthesis to prosthetic components are frequent problems related to fixed interim prosthesis fabrication with immediate dental implant loading. The purpose of this clinical trial was to evaluate a prosthetic guide made with a rapid prototype model based on virtual surgical planning. This prosthetic guide was used to fabricate fixed interim prostheses that would allow immediate implant loading after computer-guided implant installation. Nine interim prostheses were made for 9 participants with complete maxillary or mandibular edentulism. The virtual prosthetic guide was planned using computer-assisted design (CAD) software and was fabricated with rapid prototyping equipment (selective laser sintering). The prosthetic guide had 3 portions: the occlusal portion, which had occlusal registration; the connection portion, which had the information of the position and angulation of the abutment/implant projection; and the mucosa portion, which had the registration of the alveolar mucosa architecture. The prosthetic guide was used by a dental technician to fabricate prostheses. A single trained examiner evaluated the passive fit of the interim prostheses, the average time required for installing the interim prosthesis and for occlusal adjustments, the satisfaction of the patient with the prosthesis; and the screws, torque, occlusion, and prosthesis status. Passive fit was achieved between the prosthetic components and prostheses in 7 participants. The average time required for installing the fixed interim prostheses was 64.44 minutes. All participants reported being more pleased with the fixed interim prosthesis than with the prosthesis worn before implant placement. Prosthesis fractures were observed in 3 participants (2 in the maxilla and 1 in the mandible); all fractures occurred 3 months or more after delivery. No further complication was observed during 6 months of follow-up. The prosthetic guide enabled fabrication of

  13. Solid waste burial grounds interim safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Saito, G.H.

    1994-10-01

    This Interim Safety Analysis document supports the authorization basis for the interim operation and restrictions on interim operations for the near-surface land disposal of solid waste in the Solid Waste Burial Grounds. The Solid Waste Burial Grounds Interim Safety Basis supports the upgrade progress for the safety analysis report and the technical safety requirements for the operations in the Solid Waste Burial Grounds. Accident safety analysis scenarios have been analyzed based on the significant events identified in the preliminary hazards analysis. The interim safety analysis provides an evaluation of the operations in the Solid Waste Burial Grounds to determine if the radiological and hazardous material exposures will be acceptable from an overall health and safety standpoint to the worker, the onsite personnel, the public, and the environment.

  14. Evaluation of Juvenile Fall Chinook Stranding on the Hanford Reach, 1997-1999 Interim Report.

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Paul; Nugent, John; Price, William (Washington Department of Fish and Wildlife, Olympia, WA)

    1999-02-15

    Pilot work conducted in 1997 to aid the development of the study for the 1998 Evaluation of Juvenile Fall Chinook Stranding on The Hanford Reach. The objectives of the 1997 work were to: (1) identify juvenile chinook production and rearing areas..., (2) identify sampling sites and develop the statistical parameters necessary to complete the study, (3) develop a study plan..., (4) conduct field sampling activities...

  15. Deep Vadose Zone Treatability Test for the Hanford Central Plateau: Interim Post-Desiccation Monitoring Results, Fiscal Year 2014

    Energy Technology Data Exchange (ETDEWEB)

    Truex, Michael J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Strickland, Christopher E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnson, Christian D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnson, Timothy C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Clayton, Ray E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chronister, Glen B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-01

    Over decades of operation, the U.S. Department of Energy (DOE) and its predecessors have released nearly 2 trillion L (450 billion gal.) of liquid into the vadose zone at the Hanford Site. Much of this discharge of liquid waste into the vadose zone occurred in the Central Plateau, a 200 km2 (75 mi2) area that includes approximately 800 waste sites. Some of the inorganic and radionuclide contaminants in the deep vadose zone at the Hanford Site are at depths below the limit of direct exposure pathways, but may need to be remediated to protect groundwater. The Tri-Party Agencies (DOE, U.S. Environmental Protection Agency, and Washington State Department of Ecology) established Milestone M 015 50, which directed DOE to submit a treatability test plan for remediation of technetium-99 (Tc-99) and uranium in the deep vadose zone. These contaminants are mobile in the subsurface environment and have been detected at high concentrations deep in the vadose zone, and at some locations have reached groundwater. Testing technologies for remediating Tc-99 and uranium will also provide information relevant for remediating other contaminants in the vadose zone. A field test of desiccation is being conducted as an element of the DOE test plan published in March 2008 to meet Milestone M 015 50. The active desiccation portion of the test has been completed. Monitoring data have been collected at the field test site during the post-desiccation period and are reported herein. This is an interim data summary report that includes about 3 years of post-desiccation monitoring data. The DOE field test plan proscribes a total of 5 years of post-desiccation monitoring.

  16. Interim findings of an evaluation of the U.S. EnergyGuide label

    Energy Technology Data Exchange (ETDEWEB)

    Egan, Christine; Payne, Christopher T.; Thorne, Jennifer

    2000-08-20

    The United States has labeled appliances with the EnergyGuide labels since 1980. Consensus is growing that this label is confusing to consumers and has little impact on purchase decisions. Many researchers have documented that alternative labeling approaches are effective in other countries. The authors comprehensively evaluated the U.S. appliance labeling program for white goods, heating and cooling equipment, and water heaters, with emphasis on products sold through retail outlets. To date, our research has included consumer focus groups and semi-structured interviews with various market actors to assess how best to communicate energy information. With consumers and retail sales staff, five graphical designs were tested a European-style, letter based graphic; an Australian-style star-based graphic; a speedometer-style graphic; a thermometer-style graphic; and the current U.S. style. With manufacturers and contractors, we did not directly test alternate designs. Instead, we asked their opinion of and experience with the current EnergyGuide labeling program.

  17. Evaluation of Iodine Remediation Technologies in Subsurface Sediments: Interim Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Strickland, Christopher E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lawter, Amanda R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Qafoku, Nikolla [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Szecsody, James E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Truex, Michael J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Guohui [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-09-01

    Isotopes of iodine were generated during plutonium production from nine production reactors at the U.S. Department of Energy Hanford Site. The long half-life 129I generated at the Hanford Site during reactor operations was 1) stored in single-shell and double-shell tanks, 2) discharged to liquid disposal sites (e.g., cribs and trenches), 3) released to the atmosphere during fuel reprocessing operations, or 4) captured by off-gas absorbent devices (silver reactors) at chemical separations plants (PUREX, B-Plant, T-Plant, and REDOX). Releases of 129I to the subsurface have resulted in several large, though dilute, plumes in the groundwater, including the plume in the 200-UP-1 operable unit. There is also 129I remaining in the vadose zone beneath disposal or leak locations. Because 129I is an uncommon contaminant, relevant remediation experience and scientific literature are limited.

  18. Evaluation of Aluminum-Boron Carbide Neutron Absorbing Materials for Interim Storage of Used Nuclear Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lumin [Univ. of Michigan, Ann Arbor, MI (United States). Department of Nuclear Engineering and Radiological Science; Wierschke, Jonathan Brett [Univ. of Michigan, Ann Arbor, MI (United States). Department of Nuclear Engineering and Radiological Science

    2015-04-08

    The objective of this work was to understand the corrosion behavior of Boral® and Bortec® neutron absorbers over long-term deployment in a used nuclear fuel dry cask storage environment. Corrosion effects were accelerated by flowing humidified argon through an autoclave at temperatures up to 570°C. Test results show little corrosion of the aluminum matrix but that boron is leaching out of the samples. Initial tests performed at 400 and 570°C were hampered by reduced flow caused by the rapid build-up of solid deposits in the outlet lines. Analysis of the deposits by XRD shows that the deposits are comprised of boron trioxide and sassolite (H3BO3). The collection of boron- containing compounds in the outlet lines indicated that boron was being released from the samples. Observation of the exposed samples using SEM and optical microscopy show the growth of new phases in the samples. These phases were most prominent in Bortec® samples exposed at 570°C. Samples of Boral® exposed at 570°C showed minimal new phase formation but showed nearly the complete loss of boron carbide particles. Boron carbide loss was also significant in Boral samples at 400°C. However, at 400°C phases similar to those found in Bortec® were observed. The rapid loss of the boron carbide particles in the Boral® is suspected to inhibit the formation of the new secondary phases. However, Material samples in an actual dry cask environment would be exposed to temperatures closer to 300°C and less water than the lowest test. The results from this study conclude that at the temperature and humidity levels present in a dry cask environment, corrosion and boron leaching will have no effect on the performance of Boral® and Bortec® to maintain criticality control.

  19. A review of proposed Glen Canyon Dam interim operating criteria

    Energy Technology Data Exchange (ETDEWEB)

    LaGory, K.; Hlohowskyj, I.; Tomasko, D.; Hayse, J.; Durham, L.

    1992-04-01

    Three sets of interim operating criteria for Glen Canyon Dam on the Colorado River have been proposed for the period of November 1991, to the completion of the record of decision for the Glen Canyon Dam environmental impact statement (about 1993). These criteria set specific limits on dam releases, including maximum and minimum flows, up-ramp and down-ramp rates, and maximum daily fluctuation. Under the proposed interim criteria, all of these parameters would be reduced relative to historical operating criteria to protect downstream natural resources, including sediment deposits, threatened and endangered fishes, trout, the aquatic food base, and riparian plant communities. The scientific bases of the three sets of proposed operating criteria are evaluated in the present report:(1) criteria proposed by the Research/Scientific Group, associated with the Glen Canyon Environmental Studies (GCES); (2) criteria proposed state and federal officials charged with managing downstream resources; and (3) test criteria imposed from July 1991, to November 1991. Data from Phase 1 of the GCES and other sources established that the targeted natural resources are affected by dam operations, but the specific interim criteria chosen were not supported by any existing studies. It is unlikely that irreversible changes to any of the resources would occur over the interim period if historical operating criteria remained in place. It is likely that adoption of any of the sets of proposed interim operating criteria would reduce the levels of sediment transport and erosion below Glen Canyon Dam; however, these interim criteria could result in some adverse effects, including the accumulation of debris at tributary mouths, a shift of new high-water-zone vegetation into more flood-prone areas, and further declines in vegetation in the old high water zone.

  20. Comparison of fiber reinforcement placed at different locations of pontic in interim fixed partial denture to prevent fracture: An in vitro study.

    Science.gov (United States)

    Kapri, Surg Cdr Anita

    2015-01-01

    The interim restoration is an important phase in fixed prosthodontic therapy. It should provide sufficient durability to withstand the forces of mastication. A fractured interim restoration is damaging to the prosthodontic care and may lead to an unscheduled appointment for repair. Several attempts have been made to reinforce interim fixed partial dentures (FPDs). These have included the use of metal wire, a lingual cast metal reinforcement, a processed acrylic resin interim restoration, and different types of fibers, e.g., carbon, polyethylene, nylon and glass. These fibers can be placed in the occlusal, middle or cervical thirds in the FPD. There is no scientific data to evaluate the effect of fiber placement methods on the fracture resistance of clinical interim FPDs. Hence this study was designed to evaluate fracture load values of interim FPDs with different locations of fiber reinforcement. 30 interim FPD samples with polymethyl methacrylate (PMMA) reinforced with fibers at three different locations mainly occlusal, cervical and middle (10 samples each) were fabricated using a metal FPD on a master die. They were tested for fracture resistance in universal testing machine. The fracture resistance was recorded and is tabulated and analyzed statistically. The results showed that the placement of the reinforcement in the occlusal third of the pontic resulted in higher fracture resistance which was significantly higher (P fiber for reinforcing the PMMA interim restorative resin.

  1. A multicenter prospective study of patients undergoing open ventral hernia repair with intraperitoneal positioning using themonofilament polyester composite ventral patch: interim results of the PANACEA study

    Directory of Open Access Journals (Sweden)

    Berrevoet F

    2017-05-01

    month postoperative (P < 0.001, and this low pain level was maintained at 12 months postsurgery (P < 0.001. The mean global Carolina’s Comfort Scale® (CCS score improved postoperatively from 3.8 ± 6.2 at 1 month to 1.6 ± 3.5 at 6 months (P < 0.001. One patient was unsatisfied with the procedure.Conclusion: This 1-year interim analysis using PCO-VP for primary umbilical and epigastric defects shows promising results in terms of mesh ease of use, postoperative pain, and patient satisfaction. Recurrence rate is low, but, as laparoscopic evaluation shows a need for patch repositioning in some cases, an accurate surgical technique remains of utmost importance. Keywords: intraperitoneal mesh, epigastric hernia, umbilical hernia, pain

  2. Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations.

    Science.gov (United States)

    Stingl, Katarina; Schippert, Ruth; Bartz-Schmidt, Karl U; Besch, Dorothea; Cottriall, Charles L; Edwards, Thomas L; Gekeler, Florian; Greppmaier, Udo; Kiel, Katja; Koitschev, Assen; Kühlewein, Laura; MacLaren, Robert E; Ramsden, James D; Roider, Johann; Rothermel, Albrecht; Sachs, Helmut; Schröder, Greta S; Tode, Jan; Troelenberg, Nicole; Zrenner, Eberhart

    2017-01-01

    Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration in an interim analysis of two ongoing prospective clinical trials. The purpose of this article is to describe the interim functional results (efficacy). Methods: The subretinal visual prosthesis RETINA IMPLANT Alpha AMS (Retina Implant AG, Reutlingen, Germany) was implanted in 15 blind patients with hereditary retinal degenerations at four study sites with a follow-up period of 12 months (www.clinicaltrials.gov NCT01024803 and NCT02720640). Functional outcome measures included (1) screen-based standardized 2- or 4-alternative forced-choice (AFC) tests of light perception, light localization, grating detection (basic grating acuity (BaGA) test), and Landolt C-rings; (2) gray level discrimination; (3) performance during activities of daily living (ADL-table tasks). Results: Implant-mediated light perception was observed in 13/15 patients. During the observation period implant mediated localization of visual targets was possible in 13/15 patients. Correct grating detection was achieved for spatial frequencies of 0.1 cpd (cycles per degree) in 4/15; 0.33 cpd in 3/15; 0.66 cpd in 2/15; 1.0 cpd in 2/15 and 3.3 cpd in 1/15 patients. In two patients visual acuity (VA) assessed with Landolt C- rings was 20/546 and 20/1111. Of 6 possible gray levels on average 4.6 ± 0.8 (mean ± SD, n = 10) were discerned. Improvements (power ON vs. OFF) of ADL table tasks were measured in 13/15 patients. Overall, results were stable during the observation period. Serious adverse events (SAEs) were reported in 4 patients: 2 movements of the implant, readjusted in a second surgery; 4 conjunctival erosion/dehiscence, successfully treated; 1 pain event around the coil, successfully treated; 1 partial reduction of silicone oil tamponade leading to distorted vision (silicon oil successfully refilled). The majority of adverse events (AEs

  3. Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations

    Directory of Open Access Journals (Sweden)

    Katarina Stingl

    2017-08-01

    Full Text Available Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration in an interim analysis of two ongoing prospective clinical trials. The purpose of this article is to describe the interim functional results (efficacy.Methods: The subretinal visual prosthesis RETINA IMPLANT Alpha AMS (Retina Implant AG, Reutlingen, Germany was implanted in 15 blind patients with hereditary retinal degenerations at four study sites with a follow-up period of 12 months (www.clinicaltrials.gov NCT01024803 and NCT02720640. Functional outcome measures included (1 screen-based standardized 2- or 4-alternative forced-choice (AFC tests of light perception, light localization, grating detection (basic grating acuity (BaGA test, and Landolt C-rings; (2 gray level discrimination; (3 performance during activities of daily living (ADL-table tasks.Results: Implant-mediated light perception was observed in 13/15 patients. During the observation period implant mediated localization of visual targets was possible in 13/15 patients. Correct grating detection was achieved for spatial frequencies of 0.1 cpd (cycles per degree in 4/15; 0.33 cpd in 3/15; 0.66 cpd in 2/15; 1.0 cpd in 2/15 and 3.3 cpd in 1/15 patients. In two patients visual acuity (VA assessed with Landolt C- rings was 20/546 and 20/1111. Of 6 possible gray levels on average 4.6 ± 0.8 (mean ± SD, n = 10 were discerned. Improvements (power ON vs. OFF of ADL table tasks were measured in 13/15 patients. Overall, results were stable during the observation period. Serious adverse events (SAEs were reported in 4 patients: 2 movements of the implant, readjusted in a second surgery; 4 conjunctival erosion/dehiscence, successfully treated; 1 pain event around the coil, successfully treated; 1 partial reduction of silicone oil tamponade leading to distorted vision (silicon oil successfully refilled. The majority of adverse events

  4. The Intentional Interim

    Science.gov (United States)

    Nugent, Patricia A.

    2011-01-01

    The author spent years in central-office administration, most recently in an interim position. Some interim administrators simply see themselves as placeholders until the real deal is hired, giving the organization the opportunity to coast. There are others who see themselves as change agents and cannot wait to undo or redo what their predecessor…

  5. An open label, single-arm, phase II multicenter study of the safety and efficacy of CG0070 oncolytic vector regimen in patients with BCG-unresponsive non-muscle-invasive bladder cancer: Interim results.

    Science.gov (United States)

    Packiam, Vignesh T; Lamm, Donald L; Barocas, Daniel A; Trainer, Andrew; Fand, Benjamin; Davis, Ronald L; Clark, William; Kroeger, Michael; Dumbadze, Igor; Chamie, Karim; Kader, A Karim; Curran, Dominic; Gutheil, John; Kuan, Arthur; Yeung, Alex W; Steinberg, Gary D

    2017-07-26

    CG0070 is a replication-competent oncolytic adenovirus that targets bladder tumor cells through their defective retinoblastoma pathway. Prior reports of intravesical CG0070 have shown promising activity in patients with high-grade non-muscle invasive bladder cancer (NMIBC) who previously did not respond to bacillus Calmette-Guérin (BCG). However, limited accrual has hindered analysis of efficacy, particularly for pathologic subsets. We evaluated interim results of a phase II trial for intravesical CG0070 in patients with BCG-unresponsive NMIBC who refused cystectomy. At interim analysis (April 2017), 45 patients with residual high-grade Ta, T1, or carcinoma-in-situ (CIS) ± Ta/T1 had evaluable 6-month follow-up in this phase II single-arm multicenter trial (NCT02365818). All patients received at least 2 prior courses of intravesical therapy for CIS, with at least 1 being a course of BCG. Patients had either failed BCG induction therapy within 6 months or had been successfully treated with BCG with subsequent recurrence. Complete response (CR) at 6 months was defined as absence of disease on cytology, cystoscopy, and random biopsies. Of 45 patients, there were 24 pure CIS, 8 CIS + Ta, 4 CIS + T1, 6 Ta, 3 T1. Overall 6-month CR (95% CI) was 47% (32%-62%). Considering 6-month CR for pathologic subsets, pure CIS was 58% (37%-78%), CIS ± Ta/T1 50% (33%-67%), and pure Ta/T1 33% (8%-70%). At 6 months, the single patient that progressed to muscle-invasive disease had Ta and T1 tumors at baseline. No patients with pure T1 had 6-month CR. Treatment-related adverse events (AEs) at 6 months were most commonly urinary bladder spasms (36%), hematuria (28%), dysuria (25%), and urgency (22%). Immunologic treatment-related AEs included flu-like symptoms (12%) and fatigue (6%). Grade III treatment-related AEs included dysuria (3%) and hypotension (1.5%). There were no Grade IV/V treatment-related AEs. This phase II study demonstrates that intravesical CG0070 yielded an overall 47

  6. Internal Revenue Service: Assessment of Budget Request for Fiscal Year 2003 and Interim Results of 2002 Tax Filing Season

    National Research Council Canada - National Science Library

    White, James

    2002-01-01

    ...) and the 2002 tax filing season. As you requested, our statement assesses the support for various aspects of IRS s budget request, including the linkage between resources requested and expected results, and IRS's performance...

  7. Design, methods, baseline characteristics and interim results of the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA study

    Directory of Open Access Journals (Sweden)

    Hanna K. Gaggin

    2014-11-01

    Conclusions: The CASABLANCA study will examine the role of novel biomarkers and metabolomics for predicting a wide range of cardiovascular, neurologic, and renal complications in patients undergoing angiography. Full results are expected in the latter half of 2014 (ClinicalTrials.Gov # NCT00842868.

  8. Interim results of targeted therapy of patients with metastatic kidney cancer in Moscow (for the period from June 2005 to July 2015

    Directory of Open Access Journals (Sweden)

    V. I. Shirokorad

    2016-01-01

    Full Text Available The paper provides the first interim analysis of a database including information on 806 metastatic kidney cancer patients receiving targeted therapy in the cancer facilities of the Moscow Healthcare Department. It shows a comparative analysis of the periods of first-line targeted therapy with different drugs until progression is established.

  9. 2015 California Demand Response Potential Study - Charting California’s Demand Response Future. Interim Report on Phase 1 Results

    Energy Technology Data Exchange (ETDEWEB)

    Alstone, Peter; Potter, Jennifer; Piette, Mary Ann; Schwartz, Peter; Berger, Michael A.; Dunn, Laurel N.; Smith, Sarah J.; Sohn, Michael D.; Aghajanzadeh, Arian; Stensson, Sofia; Szinai, Julia

    2016-04-01

    Demand response (DR) is an important resource for keeping the electricity grid stable and efficient; deferring upgrades to generation, transmission, and distribution systems; and providing other customer economic benefits. This study estimates the potential size and cost of the available DR resource for California’s three investor-owned utilities (IOUs), as the California Public Utilities Commission (CPUC) evaluates how to enhance the role of DR in meeting California’s resource planning needs and operational requirements. As the state forges a clean energy future, the contributions of wind and solar electricity from centralized and distributed generation will fundamentally change the power grid’s operational dynamics. This transition requires careful planning to ensure sufficient capacity is available with the right characteristics – flexibility and fast response – to meet reliability needs. Illustrated is a snapshot of how net load (the difference between demand and intermittent renewables) is expected to shift. Increasing contributions from renewable generation introduces steeper ramps and a shift, into the evening, of the hours that drive capacity needs. These hours of peak capacity need are indicated by the black dots on the plots. Ultimately this study quantifies the ability and the cost of using DR resources to help meet the capacity need at these forecasted critical hours in the state.

  10. Fit of interim crowns fabricated using photopolymer-jetting 3D printing.

    Science.gov (United States)

    Mai, Hang-Nga; Lee, Kyu-Bok; Lee, Du-Hyeong

    2017-08-01

    The fit of interim crowns fabricated using 3-dimensional (3D) printing is unknown. The purpose of this in vitro study was to evaluate the fit of interim crowns fabricated using photopolymer-jetting 3D printing and to compare it with that of milling and compression molding methods. Twelve study models were fabricated by making an impression of a metal master model of the mandibular first molar. On each study model, interim crowns (N=36) were fabricated using compression molding (molding group, n=12), milling (milling group, n=12), and 3D polymer-jetting methods. The crowns were prepared as follows: molding group, overimpression technique; milling group, a 5-axis dental milling machine; and polymer-jetting group using a 3D printer. The fit of interim crowns was evaluated in the proximal, marginal, internal axial, and internal occlusal regions by using the image-superimposition and silicone-replica techniques. The Mann-Whitney U test and Kruskal-Wallis tests were used to compare the results among groups (α=.05). Compared with the molding group, the milling and polymer-jetting groups showed more accurate results in the proximal and marginal regions (P3D printing significantly enhanced the fit of interim crowns, particularly in the occlusal region. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  11. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.

    LENUS (Irish Health Repository)

    Flotte, Terence R

    2011-10-01

    Recombinant adeno-associated virus (rAAV) vectors offer promise for the gene therapy of α(1)-antitrypsin (AAT) deficiency. In our prior trial, an rAAV vector expressing human AAT (rAAV1-CB-hAAT) provided sustained, vector-derived AAT expression for >1 year. In the current phase 2 clinical trial, this same vector, produced by a herpes simplex virus complementation method, was administered to nine AAT-deficient individuals by intramuscular injection at doses of 6.0×10(11), 1.9×10(12), and 6.0×10(12) vector genomes\\/kg (n=3 subjects\\/dose). Vector-derived expression of normal (M-type) AAT in serum was dose dependent, peaked on day 30, and persisted for at least 90 days. Vector administration was well tolerated, with only mild injection site reactions and no serious adverse events. Serum creatine kinase was transiently elevated on day 30 in five of six subjects in the two higher dose groups and normalized by day 45. As expected, all subjects developed anti-AAV antibodies and interferon-γ enzyme-linked immunospot responses to AAV peptides, and no subjects developed antibodies to AAT. One subject in the mid-dose group developed T cell responses to a single AAT peptide unassociated with any clinical effects. Muscle biopsies obtained on day 90 showed strong immunostaining for AAT and moderate to marked inflammatory cell infiltrates composed primarily of CD3-reactive T lymphocytes that were primarily of the CD8(+) subtype. These results support the feasibility and safety of AAV gene therapy for AAT deficiency, and indicate that serum levels of vector-derived normal human AAT >20 μg\\/ml can be achieved. However, further improvements in the design or delivery of rAAV-AAT vectors will be required to achieve therapeutic target serum AAT concentrations.

  12. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands: aims, design and interim results.

    Science.gov (United States)

    Silva, L M; Kuipers, I M; van den Heuvel, F; Mendes, R; Berger, R M F; van Beynum, I M; Rozendaal, L; Rammeloo, L A J; van Iperen, G G; Schokking, M; Frerich, S; Blom, N A; Breur, J M P J; Helbing, W A

    2016-11-01

    Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with heart diseases. This paper presents the aims, design and interim results of the KinCor project. All children presenting at a Dutch university medical centre with a diagnosis of heart disease from 2012 onwards were eligible for registration in the KinCor database. Data entry is through a web-based portal. Entry codes have been synchronised with the European Paediatric Cardiac Coding system, allowing coupling with similar databases for adults, such as CONCOR. Between June 2012 and July 2015, 8421 patients were registered (76 % of those eligible). Median age of the patients was 9.8 years, 44.7 % were female; 6782 patients had morphological congenital heart disease. The most prevalent morphological congenital heart defects were ventricular septal defects (18 %), Tetralogy of Fallot (10 %) and transposition of great arteries (9 %). For 42 % of the patients additional diagnoses were registered. Sixty percent of patients had undergone at least one intervention (catheter intervention or surgery). The KinCor database has developed into a large registry of data of children with all types of heart disease and continues to grow. This database will provide the opportunity for epidemiological research projects on congenital and other types of heart disease in children. Entry codes are shared with the CONCOR database, which may provide a unique dataset.

  13. Evaluation of Cloud Physical Properties of ECMWF Analysis and Re-Analysis (ERA-40 and ERA Interim) against CERES Tropical Deep Convective Cloud Object Observations

    Science.gov (United States)

    Xu, Kuan-Man

    2008-01-01

    This study presents an approach that converts the vertical profiles of grid-averaged cloud properties from large-scale models to probability density functions (pdfs) of subgrid-cell cloud physical properties measured at satellite footprints. Cloud physical and radiative properties, rather than just cloud and precipitation occurrences, of assimilated cloud systems by the European Center for Medium-range Weather Forecasts (ECMWF) operational analysis (EOA) and ECMWF Re-Analyses (ERA-40 and ERA Interim) are validated against those obtained from Earth Observing System satellite cloud object data for January-August 1998 and March 2000 periods. These properties include ice water path (IWP), cloud-top height and temperature, cloud optical depth and solar and infrared radiative fluxes. Each cloud object, a contiguous region with similar cloud physical properties, is temporally and spatially matched with EOA and ERA-40 data. Results indicate that most pdfs of EOA and ERA-40 cloud physical and radiative properties agree with those of satellite observations of the tropical deep convective cloud-object type for the January-August 1998 period. There are, however, significant discrepancies in selected ranges of the cloud property pdfs such as the upper range of EOA cloud top height. A major discrepancy is that the dependence of the pdfs on the cloud object size for both EOA and ERA-40 is not as strong as in the observations. Modifications to the cloud parameterization in ECMWF that occurred in October 1999 eliminate the clouds near the tropopause but shift power of the pdf to lower cloud-top heights and greatly reduce the ranges of IWP and cloud optical depth pdfs. These features persist in ERA-40 due to the use of the same cloud parameterizations. The downgrade of data assimilation technique and the lack of snow water content information in ERA-40, not the coarser horizontal grid resolution, are also responsible for the disagreements with observed pdfs of cloud physical

  14. 40 CFR 265 interim status indicator-evaluation ground-water monitoring plan for the 216-B-63 trench

    Energy Technology Data Exchange (ETDEWEB)

    Bjornstad, B.N.; Dudziak, S.

    1989-03-01

    This document outlines a ground-water monitoring plan for the 216-B-63 trench located in the northeast corner of the 200-East Area on the Hanford Site in southeastern Washington State. It has been determined that hazardous materials (corrosives) were disposed of to the trench during past operations. Installation of an interim-status ground-water monitoring system is required to determine whether hazardous chemicals are leaching to the ground water from beneath the trench. This document summarizes the existing data that are available from near the 216-B-63 trench and presents a plan to determine the extent of ground-water contamination, if any, derived from the trench. The plan calls for the installation of four new monitoring wells located near the west end of the trench. These wells will be used to monitor ground-water levels and water quality immediately adjacent to the trench. Two existing RCRA monitoring wells, which are located near the trench and hydraulically upgradient of it, will be used as background wells. 46 refs., 15 figs., 12 tabs.

  15. Interim Results from a Study of the Impacts of Tin (II) Based Mercury Treatment in a Small Stream Ecosystem: Tims Branch, Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Looney, Brian [Savannah River National Laboratory (SRNL); BryanJr., Larry [Savannah River Ecology Laboratory; Mathews, Teresa J [ORNL; Peterson, Mark J [ORNL; Roy, W Kelly [ORNL; Jett, Robert T [ORNL; Smith, John G [ORNL

    2012-03-01

    A research team is assessing the impacts of an innovative mercury treatment system in Tims Branch, a small southeastern stream. The treatment system, installed in 2007, reduces and removes inorganic mercury from water using tin(II) (stannous) chloride addition followed by air stripping. The system results in discharge of inorganic tin to the ecosystem. This screening study is based on historical information combined with measurements of contaminant concentrations in water, fish, sediment, biofilms and invertebrates. Initial mercury data indicate that first few years of mercury treatment resulted in a significant decrease in mercury concentration in an upper trophic level fish, redfin pickerel, at all sampling locations in the impacted reach. For example, the whole body mercury concentration in redfin pickerel collected from the most impacted pond decreased approximately 72% between 2006 (pre-treatment) and 2010 (post-treatment). Over this same period, mercury concentrations in the fillet of redfin pickerel in this pond were estimated to have decreased from approximately 1.45 {micro}g/g (wet weight basis) to 0.45 {micro}g/g - a decrease from 4.8x to 1.5x the current EPA guideline concentration for mercury in fillet (0.3 {micro}g/g). Thermodynamic modeling, scanning electron microscopy, and other sampling data for tin suggest that particulate tin (IV) oxides are a significant geochemical species entering the ecosystem with elevated levels of tin measured in surficial sediments and biofilms. Detectable increases in tin in sediments and biofilms extended approximately 3km from the discharge location. Tin oxides are recalcitrant solids that are relatively non-toxic and resistant to dissolution. Work continues to develop and validate methods to analyze total tin in the collected biota samples. In general, the interim results of this screening study suggest that the treatment process has performed as predicted and that the concentration of mercury in upper trophic level

  16. Our path to the 21{sup st} century. Interim result for the environmental and energy policy; Unser Weg in das 21. Jahrhundert. Zwischenbilanz der Umwelt- und Energiepolitik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-12-15

    A future-oriented society needs a close connection between ecology and economy, if it should show solidarity. It is about growth which no longer is linked to an excessive consumption of natural resources. Instead, climate and natural resources shall be conserved. A gain in quality of life shall be enabled. This fundamental transformation process is a key target of the Federal Republic of Germany. Under this aspect, the contribution under consideration supplies an interim balance of the environmental policy and energy policy.

  17. Evaluation of Juvenile Fall Chinook Salmon Stranding on the Hanford Reach in the Columbia River, 1998 Interim Report.

    Energy Technology Data Exchange (ETDEWEB)

    Nugent, John; Newsome, Todd; Nugent, Michael (Washington Department of Fish and Wildlife, Olympia, WA)

    2001-07-27

    The Washington Department of Fish and Wildlife (WDFW) has been contracted through the Bonneville Power Administration (BPA) and the Grant County Public Utility District (GCPUD) to perform an evaluation of juvenile fall chinook salmon (Oncorhynchus tshawytscha) stranding on the Hanford Reach. The evaluation, in the second year of a multi-year study, has been developed to assess the impacts of water fluctuations from Priest Rapids Dam on rearing juvenile fall chinook salmon, other fish species, and benthic macroinvertebrates of the Hanford Reach. This document provides the results of the 1998 field season.

  18. Plutonium Finishing Plant. Interim plutonium stabilization engineering study

    Energy Technology Data Exchange (ETDEWEB)

    Sevigny, G.J.; Gallucci, R.H.; Garrett, S.M.K.; Geeting, J.G.H.; Goheen, R.S.; Molton, P.M.; Templeton, K.J.; Villegas, A.J. [Pacific Northwest Lab., Richland, WA (United States); Nass, R. [Nuclear Fuel Services, Inc. (United States)

    1995-08-01

    This report provides the results of an engineering study that evaluated the available technologies for stabilizing the plutonium stored at the Plutonium Finishing Plant located at the hanford Site in southeastern Washington. Further processing of the plutonium may be required to prepare the plutonium for interim (<50 years) storage. Specifically this document provides the current plutonium inventory and characterization, the initial screening process, and the process descriptions and flowsheets of the technologies that passed the initial screening. The conclusions and recommendations also are provided. The information contained in this report will be used to assist in the preparation of the environmental impact statement and to help decision makers determine which is the preferred technology to process the plutonium for interim storage.

  19. EMCS Retrofit Analysis - Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.C.; Salsbury, T.I.; Bell, G.C.; Huang, Y.J.; Sezgen, A.O.; Mazzucchi, R.; Romberger, J.

    1999-03-01

    This report presents the interim results of analyses carried out in the Phillip Burton Federal Building in San Francisco from 1996 to 1998. The building is the site of a major demonstration of the BACnet communication protocol. The energy management and control systems (EMCS) in the building were retrofitted with BACnet compatible controllers in order to integrate certain existing systems on one common network. In this respect, the project has been a success. Interoperability of control equipment from different manufacturers has been demonstrated in a real world environment. Besides demonstrating interoperability, the retrofits carried out in the building were also intended to enhance control strategies and capabilities, and to produce energy savings. This report presents analyses of the energy usage of HVAC systems in the building, control performance, and the reaction of the building operators. The report does not present an evaluation of the performance capabilities of the BACnet protocol. A monitoring system was installed in the building that parallels many of the EMCS sensors and data were archived over a three-year period. The authors defined pre-retrofit and post-retrofit periods and analyzed the corresponding data to establish the changes in building performance resulting from the retrofit activities. The authors also used whole-building energy simulation (DOE-2) as a tool for evaluating the effect of the retrofit changes. The results of the simulation were compared with the monitored data. Changes in operator behavior were assessed qualitatively with questionnaires. The report summarizes the findings of the analyses and makes several recommendations as to how to achieve better performance. They maintain that the full potential of the EMCS and associated systems is not being realized. The reasons for this are discussed along with possible ways of addressing this problem. They also describe a number of new technologies that could benefit systems of the type

  20. Predictors of unsuccessful interim treatment outcomes of multidrug resistant tuberculosis patients.

    Science.gov (United States)

    Atif, Muhammad; Bashir, Arslan; Ahmad, Nafees; Fatima, Razia Kaneez; Saba, Sehar; Scahill, Shane

    2017-09-29

    Interim treatment outcomes at 6-months for multidrug-resistant tuberculosis (MDR-TB) treatment are among the most basic performance monitoring and key evaluation indicators in the Stop and End TB strategy of the World Health Organization (WHO). Therefore, this study was conducted to evaluate the interim treatment outcomes of MDR-TB patients in Pakistan. This study was conducted at the Programmatic Management Unit for Drug-resistance TB (PMDT) site of the National Tuberculosis Program (NTP), Pakistan. It is located in the Chest Disease Unit (CDU) of the Bahawal Victoria Hospital (BVH), Bahawalpur, Punjab, Pakistan. Data was collected between April 1, 2014 and December 31, 2015. The medical records, Electronic Nominal Recording Reporting System (ENRS) data and MRD-TB notification forms of the MDR-TB patients registered at the PMDT site were reviewed to obtain data. For reporting and calculation of interim treatment outcomes, standardized WHO methodology was adopted. Simple logistic regression analysis was used to examine the possible association between the dependent variable (i.e. unsuccessful interim treatment outcome) and selected socio-demographic and clinical variables. A total of 100 drug-resistant TB (DR-TB) patients (all types) were registered during the study period. Out of these, 80 were MDR-TB patients for whom interim results were available. Out of the 80 MDR-TB cases, 48 (60%) were classified under the successful interim treatment outcome category. The remaining 40% had unsuccessful 6-month treatment outcomes and 12 (15%) patients died, while nine (11.3%) were lost to follow-up by six months. The final predictors of unsuccessful interim treatment outcomes were; being resistant to ofloxacin (AOR 3.23, 95% CI 0.96-10.89; p-value = 0.04), having above normal baseline serum creatinine levels (AOR 6.49, 95% CI 1.39-30.27; p-value = 0.02), and being culture positive at the second month of treatment (AOR 6.94, 95% CI 2-24.12; p-value = 0.01). Despite free

  1. ORNL fusion power demonstration study: interim report

    Energy Technology Data Exchange (ETDEWEB)

    STeiner, D.; Bettis, E. S.; Huxford, T. J.

    1977-03-01

    The purpose of the ORNL Fusion Power Demonstration Study (Demo study) is to develop a plan for demonstrating, in this century, the commercial feasibility of fusion power based on the tokamak concept. The two-year study was initiated in FY 1976, and this interim report summarizes the results for FY 1976. Major results include: (1) the outline of a three-phase plan for demonstrating the commercial feasibility of tokamak fusion power in this century; (2) a parametric analysis of tokamak costs which provides the economic basis for the demonstration plan; and (3) a critical evaluation of the technological directions, design approaches, and plasma characteristics which serve as the technical basis for the demonstration plan.

  2. [Effectiveness of a hospital-wide educational programme for infection control to reduce the rate of health-care associated infections and related sepsis (ALERTS)--methods and interim results].

    Science.gov (United States)

    Hagel, S; Ludewig, K; Frosinski, J; Hutagalung, R; Porzelius, C; Gastmeier, P; Harbarth, S; Pletz, M W; Brunkhorst, F M

    2013-08-01

    Health care associated infections (HAIs) are one of the most frequent complications of hospital care, associated with increased morbidity, mortality and considerable extra costs for the health care system. The overarching objective of the ALERTS study is to demonstrate the feasibility of a hospitalwide programme to reduce the burden of HAIs and related sepsis of at least 20 %. Prospective, quasi-experimental study covering all acute care units (27 general wards, 4 ICUs, overall 809 beds) at Jena University Hospital. Surveillance for HAIs is performed by computerized antibiotic monitoring in patients with risk factors for HAIs (i. e. intravenous and urinary catheters, surgery) on a daily basis. Following the first surveillance period a multifaceted, pragmatic infection control programme, aimed at proper hand hygiene and bundles for the prevention of the four most common HAIs will be implemented. Subsequently, a second surveillance period lasting 18 months will be conducted to measure the effect of the infection control programme, starting in May 2013. Interim results for the first surveillance period (09/2011 to 08/2012) are presented. During this period, 30,631 patients were admitted to the participating departments. According to CDC definitions we identified 1,637 HAIs, resulting in an overall incidence of 5.3 %. Based on clinical evaluation only, irrespective of the CDC definitions, an additional 944 HAIs were detected (overall HAI rate, 8.4 % [n =2581]). A substantial proportion of patients had HAI associated severe sepsis or septic shock (lower respiratory tract infection, n = 279 [37 %]; surgical site infection, n = 114 [25 %]; primary sepsis, n = 110 [32 %]; urinary tract infection, n = 46 [8 %]; other, n = 87 [22 %]). Our numbers reveal that a high number of HAIs are missed using CDC-definitions and therefore the magnitude of the problem might be underestimated. Furthermore, a high percentage of HAIs progress from localized infection to severe sepsis or

  3. Evaluation of Results from Sales Promotion Activities

    Directory of Open Access Journals (Sweden)

    Olimpia Ban

    2007-02-01

    Full Text Available An essential element of the sales promotion strategy and not only is the evaluation of the results obtained from the activities performed. Due to their nature and applicability, the evaluation of the sales promotion is much easier to be achieved, but it raises some problems. Using a hypothetical example, we have tried to develop a "classic" evaluation model of the specialty literature.

  4. CMM Interim Check Design of Experiments (U)

    Energy Technology Data Exchange (ETDEWEB)

    Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-29

    Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length and include a weekly interim check to reduce risk. The CMM interim check makes use of Renishaw’s Machine Checking Gauge which is an off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. As verification on the interim check process a design of experiments investigation was proposed to test a couple of key factors (location and inspector). The results from the two-factor factorial experiment proved that location influenced results more than the inspector or interaction.

  5. Interim positron emission tomography scans in diffuse large B-cell lymphoma: an independent expert nuclear medicine evaluation of the Eastern Cooperative Oncology Group E3404 study.

    Science.gov (United States)

    Horning, Sandra J; Juweid, Malik E; Schöder, Heiko; Wiseman, Gregory; McMillan, Alex; Swinnen, Lode J; Advani, Ranjana; Gascoyne, Randy; Quon, Andrew

    2010-01-28

    Positive interim positron emission tomography (PET) scans are thought to be associated with inferior outcomes in diffuse large B-cell lymphoma. In the E3404 diffuse large B-cell lymphoma study, PET scans at baseline and after 3 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone were centrally reviewed by a single reader. To determine the reproducibility of interim PET interpretation, an expert panel of 3 external nuclear medicine physicians visually scored baseline and interim PET scans independently and were blinded to clinical information. The binary Eastern Cooperative Oncology Group (ECOG) study criteria were based on modifications of the Harmonization Criteria; the London criteria were also applied. Of 38 interim scans, agreement was complete in 68% and 71% by ECOG and London criteria, respectively. The range of PET(+) interim scans was 16% to 34% (P = not significant) by reviewer. Moderate consistency of reviews was observed: kappa statistic = 0.445 using ECOG criteria, and kappa statistic = 0.502 using London criteria. These data, showing only moderate reproducibility among nuclear medicine experts, indicate the need to standardize PET interpretation in research and practice. This trial was registered at www.clinicaltrials.gov as #NCT00274924 [corrected].

  6. Building an evaluative culture for effective evaluation and results management

    OpenAIRE

    Mayne, John

    2008-01-01

    A weak evaluative culture undermines many attempts at building an effective evaluation and results management regime. This brief outlines practical actions that an organization can take to build and support an evaluative culture, where information on performance is deliberately sought in order to learn how to better manage and deliver programmes and services. Such an organization values empirical evidence on the results it is seeking to achieve.

  7. Decision on performing interim analysis for comparative clinical trials

    Directory of Open Access Journals (Sweden)

    Kyongsun Pak

    2017-09-01

    Full Text Available In randomized-controlled trials, interim analyses are often planned for possible early trial termination to claim superiority or futility of a new therapy. While unblinding is necessary to conduct the formal interim analysis in blinded studies, blinded data also have information about the potential treatment difference between the groups. We developed a blinded data monitoring tool that enables investigators to predict whether they observe such an unblinded interim analysis results that supports early termination of the trial. Investigators may skip some of the planned interim analyses if an early termination is unlikely. We specifically focused on blinded, randomized-controlled studies to compare binary endpoints of a new treatment with a control. Assuming one interim analysis is planned for early termination for superiority or futility, we conducted extensive simulation studies to assess the impact of the implementation of our tool on the size, power, expected number of interim analyses, and bias in the treatment effect. The numerical study showed the proposed monitoring tool does not affect size or power, but dramatically reduces the expected number of interim analyses when the effect of the treatment difference is small. The tool serves as a useful reference when interpreting the summary of the blinded data throughout the course of the trial, without losing integrity of the study. This tool could potentially save the study resources and budget by avoiding unnecessary interim analyses.

  8. Approaches to interim analysis of cancer randomised clinical trials with time to event endpoints: A survey from the Italian National Monitoring Centre for Clinical Trials

    Directory of Open Access Journals (Sweden)

    De Rosa Marisa

    2008-07-01

    Full Text Available Abstract Background Although interim analysis approaches in clinical trials are widely known, information on current practice of planned monitoring is still scarce. Reports of studies rarely include details on the strategies for both data monitoring and interim analysis. The aim of this project is to investigate the forms of monitoring used in cancer clinical trials and in particular to gather information on the role of interim analyses in the data monitoring process of a clinical trial. This study focused on the prevalence of different types of interim analyses and data monitoring in cancer clinical trials. Methods Source of investigation were the protocols of cancer clinical trials included in the Italian registry of clinical trials from 2000 to 2005. Evaluation was restricted to protocols of randomised studies with a time to event endpoint, such as overall survival (OS or progression free survival (PFS. A template data extraction form was developed and tested in a pilot phase. Selection of relevant protocols and data extraction were performed independently by two evaluators, with differences in the data assessment resolved by consensus with a third reviewer, referring back to the original protocol. Information was obtained on a general characteristics of the protocol b disease localization and patient setting; c study design d interim analyses; e DSMC. Results The analysis of the collected protocols reveals that 70.7% of the protocols incorporate statistical interim analysis plans, but only 56% have also a DSMC and be considered adequately planned. The most concerning cases are related to lack of any form of monitoring (20.0% of the protocols, and the planning of interim analysis, without DSMC (14.7%. Conclusion The results indicate that there is still insufficient attention paid to the implementation of interim analysis.

  9. Scaling Research Results: Design and Evaluation | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Scaling Research Results: Design and Evaluation. Canada's International Development Research Centre (IDRC) supports research to seek scalable solutions to improve the lives of people in the developing world. While there is general understanding of the meaning of "scaling up/ within the domain of research for ...

  10. [Multicentric prospective randomized study evaluating the interest of intravaginal electro-stimulation at home for urinary incontinence after prior perineal reeducation. Interim analysis].

    Science.gov (United States)

    Lopès, P; Levy-Toledano, R; Chiarelli, P; Rimbault, F; Marès, P

    2014-03-01

    Perineal reeducation of stress urinary incontinence is beneficial in 80% of cases. However, patients have to perform self-retraining exercises of the perineal muscles at home, in order to maintain the benefit of the physiotherapy. The aim of this study is to assess the benefit of GYNEFFIK(®), a perineal electro-stimulator, during this home-care phase. Women with stress urinary incontinence (UI) or with mixed UI (composed predominantly of stress UI) that responded to physiotherapy were included in this study in two parallel groups. The groups followed a self-reeducation program, with or without GYNEFFIK(®) electro-stimulation sessions. The comparison of the two groups was based on the rate of women for whom the benefit of the initial perineal reeducation was maintained (defined as non-worsening ICIQ and Ditrovie scales' score). According to the protocol, an interim analysis was performed on 95 patients (i.e. almost half of the expected sample size) who had had at least one evaluation under treatment, among which 44 patients had finished the study. The therapeutic benefit of the initial perineal reeducation was maintained in 87.8% of the GYNEFFIK(®) patient group, while it was maintained in 52.2% (P=0.0001) in the usual care group (i.e. who did not use electro-stimulation). Likewise, patient had a more favorable subjective impression when using GYNEFFIK(®) (83.7% versus 60.0% in the usual care group) as they felt that they improved during the study. In the GYNEFFIK(®) group, no increase in symptoms was reported, whereas almost one out of five patients in the usual care group felt that their condition had worsened. Copyright © 2014. Published by Elsevier SAS.

  11. Experience collecting interim data on mortality: an example from the RALES study

    Directory of Open Access Journals (Sweden)

    Kulbertus Henri

    2001-02-01

    Full Text Available Abstract Introduction The Randomized Aldactone Evaluation Study (RALES randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death from all causes. Randomization began on March 24, 1995; recruitment was completed on December 31, 1996; follow-up was scheduled to continue through December 31, 1999. Evidence of a sizeable benefit on mortality emerged early in the RALES. The RALES data safety monitoring board (DSMB, which met semiannually throughout the trial, used a prespecified statistical guideline to recommend stopping for efficacy. At the DSMB's request, its meetings were preceded by an 'endpoint sweep', that is, a census of all participants to confirm their vital status. Methods We used computer simulation to evaluate the effect of the sweeps. Results The sweeps led to an estimated 5 to 8% increase in the number of reported deaths at the fourth and fifth interim analyses. The data crossed the statistical boundary at the fifth interim analysis. If investigators had reported all deaths within the protocol-required 24-h window, the DSMB might have recommended stopping after the fourth interim analysis. Discussion Although endpoint sweeps can cause practical problems at the clinical centers, sweeps are very useful if the intervals between patient visits or contact are long or if endpoints require adjudication by committee, reading center, or central laboratory. Conclusion We recommend that trials with interim analyses institute active reporting of the primary endpoints and endpoint sweeps.

  12. Continued evaluation of compact heat exchangers for OTEC application. Interim progress report, February 15, 1977--August 15, 1977

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, J.G.; Heronemus, W.E.

    1977-08-01

    Progress on the continued UMass technical evaluation of compact heat exchangers for OTEC applications is summarized. Objectives of this study include: (1) Analytical and experimental evaluation of the performance characteristics of compact heat exchangers (using ammonia as a working fluid) over the entire range of OTEC system conditions, (2) An evaluation of the applicable manufacturing processes, maintenance requirements and arrangement concepts for large scale compact heat exchangers with specific emphasis on their total economics. This progress report also includes a technical report on compact heat exchanger design information for OTEC application. Contained in this report are a review of previous compact heat exchanger work, a literature review of applicable two phase evaporating and condensing technical publications, and recommendations for compact heat exchanger analytical design procedure.

  13. CMM Interim Check (U)

    Energy Technology Data Exchange (ETDEWEB)

    Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-23

    Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length. Unfortunately, several nonconformance reports have been generated to document the discovery of a certified machine found out of tolerance during a calibration closeout. In an effort to reduce risk to product quality two solutions were proposed – shorten the calibration cycle which could be costly, or perform an interim check to monitor the machine’s performance between cycles. The CMM interim check discussed makes use of Renishaw’s Machine Checking Gauge. This off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. Data was gathered, analyzed, and simulated from seven machines in seventeen different configurations to create statistical process control run charts for on-the-floor monitoring.

  14. 24 CFR 7.44 - Interim relief.

    Science.gov (United States)

    2010-04-01

    ... will result in the dismissal of the Department's appeal. (e) The Department may, by notice to the... conditional restoration of the employee to duty status in the position specified in the decision, pending the outcome of the Department appeal. The employee may decline the offer of interim relief. (b) Service under...

  15. Interim Guidelines Growing Longleaf Seedlings in Containers

    Science.gov (United States)

    James P. Barnett; Mark J. Hainds; George A. Hernandez

    2002-01-01

    These interim guidelines are designed for producers and users of longleaf pine container stock. They are not meant to exclude any container product. The seedling specifications listed in the preferred category are attainable by the grower and will result in excellent field sur vival and early height growth.

  16. Interim Evaluation of the Pilot Program of the Truancy Case Management Partnership Intervention in the District of Columbia

    Science.gov (United States)

    Liberman, Akiva; Cahill, Meagan; Cramer, Lindsey

    2012-01-01

    The Case Management Partnership Initiative (CMPI) addresses chronic truancy by linking truant ninth graders and their families to social services and case management, along with regular interagency case management meetings. A pilot was conducted at Anacostia and Ballou High Schools in 2011-2012. The implementation evaluation found that the pilot…

  17. Evaluation of Worker Profiling and Reemployment Services Systems: Interim Report. Unemployment Insurance Occasional Paper 96-1.

    Science.gov (United States)

    Hawkins, Evelyn K.; And Others

    The Evaluation of Worker Profiling and Reemployment Services (WPRS) systems was designed to provide the U.S. Department of Labor information on how states are designing, implementing, and operating their worker profiling and reemployment services systems for dislocated workers and to compare the effectiveness of different state approaches to…

  18. Pre-Service and In-Service Training of Georgia Correctional Personnel. An Interim Evaluation (1-091).

    Science.gov (United States)

    Nosin, Jerome A.

    Evaluation activities related to the Orientation Training Program (OTP) are summarized. The OTP is a three-week program which includes orientation, human relations training and security. Correctional officers were found to be more authoritarian and security-conscious than non-correctional personnel. Scores of correctional officers in Communication…

  19. EVALUATION OF THE EFFECTIVENESS OF COATINGS IN REDUCING DISLODGEABLE ARSENIC, CHROMIUM, AND COPPER FROM CCA TREATED WOOD, INTERIM DATA REPORT

    Science.gov (United States)

    EPA is approximately 20 months into a project to evaluate the performance of wood coatings as a way to prevent arsenic, chromium and copper exposure from the surfaces of CCA treated wood. Potential dermal exposure, as measured by wipe sampling dislodgeable CCA chemical from wood ...

  20. Resource Use and Real-World Outcomes for Ranibizumab Treat and Extend for Neovascular Age-Related Macular Degeneration in the UK: Interim Results from TERRA.

    Science.gov (United States)

    Yang, Yit; Downey, Louise; Mehta, Hemal; Mushtaq, Bushra; Narendran, Niro; Patel, Nishal; Patel, Praveen J; Ayan, Filis; Gibson, Kara; Igwe, Franklin; Jeffery, Pete

    2017-06-01

    Ranibizumab is an inhibitor of vascular endothelial growth factor-A (anti-VEGF) approved for the treatment of neovascular age-related macular degeneration (nAMD). The treat and extend (T&E) regimen can potentially reduce the burden of clinic visits compared with a pro re nata (PRN) regimen. Retrospective, interim analyses of clinical effectiveness, treatment and resource use patterns were conducted using real-world data in England and Wales from the TERRA study. Two cohorts, those switching from a PRN to a T&E regimen ('prior PRN') and those initiating ranibizumab on the T&E regimen as their first anti-VEGF therapy ('anti-VEGF-naïve') were enrolled in TERRA. Retrospective clinical assessments were gathered from medical records, while resource use patterns were collected via an operating cost questionnaire completed by each study site. At the interim analysis cut-off date (15 November 2016), 11 sites had enrolled 145 patients (prior PRN: n = 110; anti-VEGF-naïve: n = 35). Mean change from baseline (date of first injection) in visual acuity and central subfield retinal thickness to 12 months was +7.6 Early Treatment Diabetic Retinopathy Study letters [95% confidence interval (CI) 2.8, 12.4; p = 0.003; n = 27] and -67.7 μm (95% CI -106.5, -28.9; p = 0.001, n = 29), respectively, in the anti-VEGF-naïve cohort. Most T&E clinics were run as one-stop services (same-day monitoring and injection), whereas 4/10 PRN clinics were run as two-stop services (monitoring and injection on different days). In general, one-stop clinics used less staff resources and were likely to be shorter in duration for healthcare providers than the cumulative time spent for two-stop clinics. This is the first real-world observational study conducted in England and Wales demonstrating the effectiveness of the ranibizumab T&E regimen in anti-VEGF-naïve patients. T&E is compatible with one-stop clinic services, which these real-world data suggest to be less resource intensive than

  1. ADS-5102 (Amantadine) Extended-Release Capsules for Levodopa-Induced Dyskinesia in Parkinson’s Disease (EASE LID 2 Study): Interim Results of an Open-Label Safety Study

    Science.gov (United States)

    Hauser, Robert A.; Pahwa, Rajesh; Tanner, Caroline M.; Oertel, Wolfgang; Isaacson, Stuart H.; Johnson, Reed; Felt, Larissa; Stempien, Mary Jean

    2017-01-01

    Background: Medical treatment of levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD) is an unmet need. ADS-5102 (amantadine) extended-release capsules is being developed for the treatment of LID in patients with PD. Objective: Evaluate the long-term safety and tolerability of 274 mg ADS-5102 for LID in PD. Methods: In an ongoing, open-label safety study (NCT02202551), PD patients with LID received 274 mg of ADS-5102 once daily at bedtime. Patients were recruited from previous ADS-5102 trials. In addition, patients were enrolled who were ineligible for previous ADS-5102 trials due to previous implantation of deep-brain stimulation (DBS) devices. The primary outcome measure was safety assessed through adverse events (AEs). Efficacy was assessed using the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Part IV and its subparts. Results: For this interim analysis, 223 patients received ADS-5102 for a mean duration of 348 (SD 182) days. The most common AEs included falls (25.1%), visual hallucinations (19.3%), peripheral edema (13.0%), and constipation (12.6%). Overall, 32 patients (14.3%) discontinued due to an AE. In patients receiving placebo in previous studies, the mean MDS-UPDRS, Part IV scores decreased by 3.4 points from baseline (n = 78) to week 8 and remained stable through week 64 (n = 21). In patients receiving ADS-5102 in previous studies, the mean baseline (n = 61) MDS-UPDRS, Part IV score was low due to the response to ADS-5102 in previous studies and remained stable through week 64 (total of 88 weeks; n = 21). The effect was primarily due to reduction in item 4.2 (functional impact of dyskinesia) and item 4.4 (functional impact of motor fluctuations). Conclusions: ADS-5102 was generally well tolerated in all groups, including DBS patients, and the safety profile was consistent with previous controlled studies. Long-term durability and tolerability were shown from the double-blind studies

  2. Evaluative studies in nuclear medicine research. Interim progress report, July 1, 1975--June 30, 1976. [Diagnostic value of brain scans

    Energy Technology Data Exchange (ETDEWEB)

    Potchen, E.J.

    1976-01-01

    Data relating to the determination of the efficacy of radionuclide brain scanning have been analyzed. The data were gathered at a teaching hospital by use of a prospective questionnaire followed by a retrospective study of the result of the brain scan examination. Data analysis was accomplished using a method of pattern discovery which relates selected outcomes such as normal and abnormal brain scans to patient attributes (signs, symptoms, history, and previous test results). The objective of the analysis was the identification of patterns or clusters of patient attributes which have a high probability of acting as predictors of the outcome of the brain scan.

  3. Standard guide for evaluation of materials used in extended service of interim spent nuclear fuel dry storage systems

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 Part of the total inventory of commercial spent nuclear fuel (SNF) is stored in dry cask storage systems (DCSS) under licenses granted by the U.S. Nuclear Regulatory Commission (NRC). The purpose of this guide is to provide information to assist in supporting the renewal of these licenses, safely and without removal of the SNF from its licensed confinement, for periods beyond those governed by the term of the original license. This guide provides information on materials behavior under conditions that may be important to safety evaluations for the extended service of the renewal period. This guide is written for DCSS containing light water reactor (LWR) fuel that is clad in zirconium alloy material and stored in accordance with the Code of Federal Regulations (CFR), at an independent spent-fuel storage installation (ISFSI). The components of an ISFSI, addressed in this document, include the commercial SNF, canister, cask, and all parts of the storage installation including the ISFSI pad. The language of t...

  4. Uncertainty of cosmetic evaluation after accelerated partial breast irradiation: interim analysis of a Japanese prospective multi-institutional feasibility study.

    Science.gov (United States)

    Yoden, Eisaku; Nose, Takayuki; Otani, Yuki; Asahi, Shuuji; Tsukiyama, Iwao; Dokiya, Takushi; Saeki, Toshiaki; Fukuda, Ichirou; Sekine, Hiroshi; Shikama, Naoto; Kumazaki, Yu; Takahashi, Takao; Yoshida, Ken; Kotsuma, Tadayuki; Masuda, Norikazu; Nakashima, Kazutaka; Matsumura, Taisei; Nakagawa, Shino; Tachiiri, Seiji; Moriguchi, Yoshio; Itami, Jun; Oguchi, Masahiko

    2017-07-01

    We conducted a multi-institutional prospective study on accelerated partial breast irradiation (APBI) using interstitial brachytherapy. The clinical results over a minimum follow-up period of 30 months are presented here. Forty-six patients with breast cancer were treated with breast-conserving surgery and postoperative APBI. After confirmation of negative surgical margins and negative lymph nodes, a high-dose-rate brachytherapy protocol of 36 Gy/6 fractions was carried out. All clinical data were prospectively collected using the Common Terminology Criteria for Adverse Events ver. 3.0. No recurrence was observed. Cumulative rates of grade 2 or higher late sequelae were 25% for fibrosis, 2% for fractures, 9% for pain, and 9% for soft tissue necrosis. Rates of excellent or good cosmetic results as assessed by the physician and patient were 93 and 89% at the 12-month follow-up and 76 and 74% at the 30-month follow-up, respectively. Large volumes of resected tissue in small breasts were associated with fibrosis of grade 2 or higher. APBI in Japanese women provides satisfactory clinical results except for cosmetic outcomes. There is some difficulty with the assessment of fibrosis and cosmetic outcomes, especially in patients with small breasts. UMIN000001677.

  5. Application of Spatial Data Modeling Systems, Geographical Information Systems (GIS), and Transportation Routing Optimization Methods for Evaluating Integrated Deployment of Interim Spent Fuel Storage Installations and Advanced Nuclear Plants

    Energy Technology Data Exchange (ETDEWEB)

    Mays, Gary T [ORNL; Belles, Randy [ORNL; Cetiner, Sacit M [ORNL; Howard, Rob L [ORNL; Liu, Cheng [ORNL; Mueller, Don [ORNL; Omitaomu, Olufemi A [ORNL; Peterson, Steven K [ORNL; Scaglione, John M [ORNL

    2012-06-01

    The objective of this siting study work is to support DOE in evaluating integrated advanced nuclear plant and ISFSI deployment options in the future. This study looks at several nuclear power plant growth scenarios that consider the locations of existing and planned commercial nuclear power plants integrated with the establishment of consolidated interim spent fuel storage installations (ISFSIs). This research project is aimed at providing methodologies, information, and insights that inform the process for determining and optimizing candidate areas for new advanced nuclear power generation plants and consolidated ISFSIs to meet projected US electric power demands for the future.

  6. Interim storage study report

    Energy Technology Data Exchange (ETDEWEB)

    Rawlins, J.K.

    1998-02-01

    High-level radioactive waste (HLW) stored at the Idaho Chemical Processing Plant (ICPP) in the form of calcine and liquid and liquid sodium-bearing waste (SBW) will be processed to provide a stable waste form and prepare the waste to be transported to a permanent repository. Because a permanent repository will not be available when the waste is processed, the waste must be stored at ICPP in an Interim Storage Facility (ISF). This report documents consideration of an ISF for each of the waste processing options under consideration.

  7. Different predictive values of interim (18)F-FDG PET/CT in germinal center like and non-germinal center like diffuse large B-cell lymphoma.

    Science.gov (United States)

    Kim, Jihyun; Lee, Jeong-Ok; Paik, Jin Ho; Lee, Won Woo; Kim, Sang Eun; Song, Yoo Sung

    2017-01-01

    Diffuse large B-cell lymphoma (DLBCL) is a pathologically heterogeneous disease with different prognoses according to its molecular profiles. Despite the broad usage of (18)F-fluoro-2-dexoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT), previous studies that have investigated the value of interim (18)F-FDG PET/CT in DLBCL have given the controversial results. The purpose of this study was to evaluate the prognostic value of interim (18)F-FDG PET/CT in DLBCL according to germinal center B cell-like (GCB) and non-GCB molecular profiling. We enrolled 118 newly diagnosed DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Interim (18)F-FDG PET/CT scans performed after 2 or 3 cycles of R-CHOP treatment were evaluated based on the Lugano response criteria. Patients were grouped as GCB or non-GCB molecular subtypes according to immunohistochemistry results of CD10, BCL6, and MUM1, based on Hans' algorithm. In total 118 DLBCL patients, 35 % were classified as GCB, and 65 % were classified as non-GCB. Interim PET/CT was negative in 70 %, and positive in 30 %. During the median follow-up period of 23 months, the positive interim (18)F-FDG PET/CT group showed significantly inferior progression free survival (PFS) compared to the negative interim (18)F-FDG PET/CT group (P = 0.0004) in entire patients. A subgroup analysis according to molecular profiling demonstrated significant difference of PFS between the positive and negative interim (18)F-FDG PET groups in GCB subtype of DLBCL (P = 0.0001), but there was no significant difference of PFS between the positive and negative interim (18)F-FDG PET groups in non-GCB subtype of DLBCL. Interim (18)F-FDG PET/CT scanning had a significant predictive value for disease progression in patients with the GCB subtype of DLBCL treated with R-CHOP, but not in those with the non-GCB subtype. Therefore, molecular profiles of DLBCL should be

  8. EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

    Directory of Open Access Journals (Sweden)

    Romanelli M

    2017-12-01

    Full Text Available Marco Romanelli,1 Alberto Piaggesi,2 Giovanni Scapagnini,3 Valentina Dini,1 Agata Janowska,1 Elisabetta Iacopi,2 Carlotta Scarpa,4 Stéphane Fauverghe,5 Franco Bassetto4 1Wound Healing Research Unit, Division of Dermatology, School of Medicine, University of Pisa, Pisa, 2Diabetic Foot Section, Department of Medicine, University of Pisa, Pisa, 3Department of Medicine and Health Sciences, School of Medicine, University of Molise, Campobasso, 4Clinic of Plastic and Reconstructive Surgery, Padova University-Hospital, Padova, Italy; 5KLOX Technologies Inc., Laval, QC, Canada Objective: Interest has grown regarding photobiomodulation (PBM with low-level light therapy, which has been shown to positively affect the stages of the wound healing process. In a real-life context clinical setting, the objective of the EUREKA study was to investigate efficacy, safety, and quality of life associated with the use of a BioPhotonic gel (LumiHeal™ in the treatment of chronic wounds such as venous leg ulcers (VLUs, diabetic foot ulcers (DFUs, and pressure ulcers (PUs. This BioPhotonic gel represents a new, first-in-class emission spectrum of light, including fluorescence, to induce PBM and modulate healing.Design: The multicenter, prospective, interventional, uncontrolled, open-label study enrolled 100 patients in 12 wound centers in Italy. We performed an early interim analysis based on the first 33 subjects (13 VLU, 17 DFU, 3 PU in seven centers who completed the study.Main results: Seventeen patients (52% achieved total wound closure (full re-epithelialization for 2 weeks during the study period. Two patients (6% were considered “almost closed” (decrease of the wound area of more than 90% at study end and three others (9% were considered “ready for skin grafting”. No related serious adverse events were observed, and the compliance was excellent. After the treatment, the average time to “pain-free” was 11.9 days in the VLU group. Quality of life was

  9. Kenya's Radio Language Arts Project: evaluation results.

    Science.gov (United States)

    Oxford, R L

    1985-01-01

    The Kenya Radio Language Arts Project (RLAP), which has just been completed, documents the effectiveness of interactive radio-based educational instruction. Analyses in the areas of listening, reading, speaking, and writing show that children in radio classrooms consistently scored better than children in nonradio classrooms in every test. An evaluation of the project was conducted with the assistance of the Center for Applied Linguistics (CAL). Evaluation results came from a variety of sources, including language tests, observations, interviews, demographic and administrative records, and an attitude survey. A large proportion of the project's students were considerably transient. Only 22% of the total student population of 3908 were "normal progression" students -- that is, they advanced regularly through their education during the life of the project. Students who moved from the area, failed a standard (grade), dropped out, or were otherwise untrackable, comprised the remaining 78% of the total. 7 districts were included in the project. Tests were developed for listening and reading in Standards 1, 2, and 3 and in speaking and writing in Standards 2 and 3. The achievement tests were based on the official Kenya curriculum for those standards, so as to measure achievement against the curriculum. Nearly all the differences were highly significant statistically, with a probability of less than 1 in 1000 that the findings could have occurred by chance. Standard 1 radio students scored nearly 8 points higher than did their counterparts in the control group. Standard 2 and 3 radio students outperformed the control students by 4 points. The radio group consistently outperformed the control group in reading, writing, and speaking. Unstructured interviews and observations were conducted by the RLAP field staff. Overwhelmingly positive attitudes about the project prevailed among project teachers and headmasters. The data demonstrate that RLAP works. In fact, it works so

  10. International validation study for interim PET in ABVD-treated, advanced-stage hodgkin lymphoma

    DEFF Research Database (Denmark)

    Biggi, Alberto; Gallamini, Andrea; Chauvie, Stephane

    2013-01-01

    in lymphoma. Accordingly, an international validation study was undertaken with the primary aim of validating the prognostic role of interim PET using the Deauville 5-point score to evaluate images and with the secondary aim of measuring concordance rates among reviewers using the same 5-point score......At present, there are no standard criteria that have been validated for interim PET reporting in lymphoma. In 2009, an international workshop attended by hematologists and nuclear medicine experts in Deauville, France, proposed to develop simple and reproducible rules for interim PET reporting....... This paper focuses on the criteria for interpretation of interim PET and on concordance rates....

  11. Evaluation of ERA-Interim, MERRA, NCEP-DOE R2 and CFSR Reanalysis precipitation Data using Gauge Observation over Ethiopia for a period of 33 years

    Directory of Open Access Journals (Sweden)

    Tewodros Woldemariam Tesfaye

    2017-09-01

    Full Text Available The vital demand of reliable climatic and hydrologic data of fine spatial and temporal resolution triggered the employment of reanalysis datasets as a surrogate in most of the hydrological modelling exercises. This study examines the performance of four widely used reanalysis datasets: ERA-Interim, NCEP-DOE R2, MERRA and CFSR, in reproducing the spatio-temporal characteristics of observed daily precipitation of different stations spread across Ethiopia, East Africa. The appropriateness of relying on reanalysis datasets for hydrologic modelling, climate change impact assessment and regional modelling studies is assessed using various statistical and non-parametric techniques. ERA-Interim is found to exhibit higher correlation and least root mean square error values with observed daily rainfall, which is followed by CFSR and MERRA in most of the stations. The variability of daily precipitation is better captured by ERA, CFSR and MERRA, while NCEP-DOE R2 overestimated the spread of the precipitation data. While ERA overestimates the probability of moderate rainfall, it is seemingly better in capturing the probability of low rainfall. CFSR captures the overall distribution reasonable well. NCEP-DOE R2 appears to be outperforming others in capturing the probabilities of higher magnitude rainfall. Climatological seasonal cycle and the characteristics of wet and dry spells are compared further, where ERA seemingly replicates the pattern more effectively. However, observed rainfall exhibits higher frequency of short wet spells when compared to that of any reanalysis datasets. MERRA relatively underperforms in simulating the wet spell characteristics of observed daily rainfall. CFSR overestimates the mean wet spell length and mean dry spell length. Spatial trend analysis indicates that the northern and central western Ethiopia show increasing trends, whereas the Central and Eastern Ethiopia as well as the Southern Ethiopia stations show either no trend

  12. Decipher test impacts decision making among patients considering adjuvant and salvage treatment after radical prostatectomy: Interim results from the Multicenter Prospective PRO-IMPACT study.

    Science.gov (United States)

    Gore, John L; du Plessis, Marguerite; Santiago-Jiménez, María; Yousefi, Kasra; Thompson, Darby J S; Karsh, Lawrence; Lane, Brian R; Franks, Michael; Chen, David Y T; Bandyk, Mark; Bianco, Fernando J; Brown, Gordon; Clark, William; Kibel, Adam S; Kim, Hyung L; Lowrance, William; Manoharan, Murugesan; Maroni, Paul; Perrapato, Scott; Sieber, Paul; Trabulsi, Edouard J; Waterhouse, Robert; Davicioni, Elai; Lotan, Yair; Lin, Daniel W

    2017-08-01

    Patients with prostate cancer and their providers face uncertainty as they consider adjuvant radiotherapy (ART) or salvage radiotherapy (SRT) after undergoing radical prostatectomy. The authors prospectively evaluated the impact of the Decipher test, which predicts metastasis risk after radical prostatectomy, on decision making for ART and SRT. A total of 150 patients who were considering ART and 115 who were considering SRT were enrolled. Providers submitted a management recommendation before processing the Decipher test and again at the time of receipt of the test results. Patients completed validated surveys on prostate cancer (PCa)-specific decisional effectiveness and PCa-related anxiety. Before the Decipher test, observation was recommended for 89% of patients considering ART and 58% of patients considering SRT. After Decipher testing, 18% (95% confidence interval [95% CI], 12%-25%) of treatment recommendations changed in the ART arm, including 31% among high-risk patients; and 32% (95% CI, 24%-42%) of management recommendations changed in the salvage arm, including 56% among high-risk patients. Decisional Conflict Scale (DCS) scores were better after viewing Decipher test results (ART arm: median DCS before Decipher, 25 and after Decipher, 19 [Pfear of PCa disease recurrence in the ART arm (P = .02) and PCa-specific anxiety in the SRT arm (P = .05) decreased significantly among low-risk patients. Decipher results reported per 5% increase in 5-year metastasis probability were associated with the decision to pursue ART (odds ratio, 1.48; 95% CI, 1.19-1.85) and SRT (odds ratio, 1.41; 95% CI, 1.09-1.81) in multivariable logistic regression analysis. Knowledge of Decipher test results was associated with treatment decision making and improved decisional effectiveness among men with PCa who were considering ART and SRT. Cancer 2017;123:2850-59. © 2017 American Cancer Society. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American

  13. Preventive maintenance study : interim report.

    Science.gov (United States)

    2017-09-01

    This interim report details the performance of 69 test sites treated with various preventive maintenance treatments. The maintenance treatments applied included crack sealing, full lane chip sealing, wheel path chip sealing, dig outs (mill and fill),...

  14. Immediate rehabilitation of the edentulous jaws with full fixed prostheses supported by four implants: interim results of a single cohort prospective study.

    Science.gov (United States)

    Agliardi, Enrico; Panigatti, Stefano; Clericò, Matteo; Villa, Cristina; Malò, Paulo

    2010-05-01

    The purpose of this study was to prospectively evaluate the clinical and radiographic outcomes of immediately loaded full-arch fixed prostheses supported by a combination of axially and non-axially positioned implants in a large cohort of patients with completely edentulous jaws, up to 5 years of function. One hundred and seventy-three edentulous patients (80 males and 93 females) were enrolled according to specific selection criteria. Each patient received a full-arch fixed prosthesis supported by two distal tilted implants and two anterior axially placed implants. The provisional functional acrylic prosthesis was delivered the same day as surgery in all cases. All cases were finalized 4-6 months later. The patients were scheduled for follow-up at 6 and 12 months of function, and annually up to 5 years. At each follow-up plaque and bleeding score was assessed and radiographic evaluation of marginal bone level was performed. The overall follow-up range was 4-59 months. A total of 154 immediately loaded prostheses (61 in the maxilla and 93 in the mandible) were in function for at least 1 year and were considered for the analysis. Four axially placed implants failed in the maxilla and one tilted implant in the mandible, all within 6 months of loading. No further implant failure occurred to date. Implant survival at 1 year was 98.36% and 99.73% for the maxilla and the mandible, respectively. Marginal bone loss at 1 year averaged 0.9+/-0.7 mm in the maxilla (204 implants) and 1.2+/-0.9 mm in the mandible (292 implants). No difference was found in marginal bone loss between axial and tilted implants. Plaque and bleeding scores progressively improved from 6 to 12 months. Fracture of the acrylic prosthesis occurred in 14% of total cases. The present preliminary results from a relatively large sample size suggest that the present technique can be considered a viable treatment option for the immediate rehabilitation of both mandible and maxilla.

  15. 1998 interim 242-A Evaporator tank system integrity assessment report

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, C.E.

    1998-07-02

    This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) under contract to Lockheed-Martin Hanford Company (LMHC) for Waste Management Hanford (WMH), the 242-A Evaporator (facility) operations contractor for Fluor Daniel Hanford, and the US Department of Energy, the system owner. The contract specifies that FDNW perform an interim (5 year) integrity assessment of the facility and prepare a written IAR in accordance with Washington Administrative Code (WAC) 173-303-640. The WAC 173-303 defines a treatment, storage, or disposal (TSD) facility tank system as the ``dangerous waste storage or treatment tank and its ancillary equipment and containment.`` This integrity assessment evaluates the two tank systems at the facility: the evaporator vessel, C-A-1 (also called the vapor-liquid separator), and the condensate collection tank, TK-C-100. This IAR evaluates the 242-A facility tank systems up to, but not including, the last valve or flanged connection inside the facility perimeter. The initial integrity assessment performed on the facility evaluated certain subsystems not directly in contact with dangerous waste, such as the steam condensate and used raw water subsystems, to provide technical information. These subsystems were not evaluated in this IAR. The last major upgrade to the facility was project B-534. The facility modifications, as a result of project B-534, were evaluated in the 1993 facility interim integrity assessment. Since that time, the following upgrades have occurred in the facility: installation of a process condensate recycle system, and installation of a package steam boiler to provide steam for the facility. The package boiler is not within the scope of the facility TSD.

  16. Interim Design Report

    CERN Document Server

    Choubey, S.; Goswami, S.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; Ellis, M.; Kyberd, P.; Benedetto, E.; Fernandez-Martinez, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Martini, M.; Prior, G.; Ballett, P.; Pascoli, S.; Bross, A.; Geer, S.; Johnstone, C.; Kopp, J.; Mokhov, N.; Morfin, J.; Neuffer, D.; Parke, S.; Popovic, M.; Strait, J.; Striganov, S.; Blondel, A.; Dufour, F.; Laing, A.; Soler, F.J.P; Lindner, M.; Schwetz, T.; Alekou, A.; Apollonio, M.; Aslaninejad, M.; Bontoiu, C.; Dornan, P.; Eccleston, R.; Kurup, A.; Long, K.; Pasternak, J.; Pozimski, J.; Bogacz, A.; Morozov, V.; Roblin, Y.; Bhattacharya, S.; Majumdar, D.; Mori, Y.; Planche, T.; Zisman, M.; Cline, D.; Stratakis, D.; Ding, X.; Coloma, P.; Donini, A.; Gavela, B.; Lopez Pavon, J.; Maltoni, M.; Bromberg, C.; Bonesini, M.; Hart, T.; Kudenko, Y.; Mondal, N.; Antusch, S.; Blennow, M.; Ota, T.; Abrams, R.J.; Ankenbrandt, C.M.; Beard, K.B.; Cummings, M.A.C.; Flanagan, G.; Johnson, R.P.; Roberts, T.J.; Yoshikawa, C.Y.; Migliozzi, P.; Palladino, V.; de Gouvea, A.; Graves, V.B.; Kuno, Y.; Peltoniemi, J.; Blackmore, V.; Cobb, J.; Witte, H.; Mezzetto, M.; Rigolin, S.; McDonald, K.T.; Coney, L.; Hanson, G.; Snopok, P.; Tortora, L.; Andreopoulos, C.; Bennett, J.R.J.; Brooks, S.; Caretta, O.; Davenne, T.; Densham, C.; Edgecock, R.; Kelliher, D.; Loveridge, P.; McFarland, A.; Machida, S.; Prior, C.; Rees, G.; Rogers, C.; Thomason, J.W.G.; Booth, C.; Skoro, G.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Samulyak, R.; Mishra, S.R.; Petti, R.; Dracos, M.; Yasuda, O.; Agarwalla, S.K.; Cervera-Villanueva, A.; Gomez-Cadenas, J.J.; Hernandez, P.; Li, T.; Martin-Albo, J.; Huber, P.; Back, J.; Barker, G.; Harrison, P.; Meloni, D.; Tang, J.; Winter, W.

    2011-01-01

    The International Design Study for the Neutrino Factory (the IDS-NF) was established by the community at the ninth "International Workshop on Neutrino Factories, super-beams, and beta- beams" which was held in Okayama in August 2007. The IDS-NF mandate is to deliver the Reference Design Report (RDR) for the facility on the timescale of 2012/13. In addition, the mandate for the study [3] requires an Interim Design Report to be delivered midway through the project as a step on the way to the RDR. This document, the IDR, has two functions: it marks the point in the IDS-NF at which the emphasis turns to the engineering studies required to deliver the RDR and it documents baseline concepts for the accelerator complex, the neutrino detectors, and the instrumentation systems. The IDS-NF is, in essence, a site-independent study. Example sites, CERN, FNAL, and RAL, have been identified to allow site-specific issues to be addressed in the cost analysis that will be presented in the RDR. The choice of example sites shou...

  17. Methods Data Qualification Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    R. Sam Alessi; Tami Grimmett; Leng Vang; Dave McGrath

    2010-09-01

    The overall goal of the Next Generation Nuclear Plant (NGNP) Data Management and Analysis System (NDMAS) is to maintain data provenance for all NGNP data including the Methods component of NGNP data. Multiple means are available to access data stored in NDMAS. A web portal environment allows users to access data, view the results of qualification tests and view graphs and charts of various attributes of the data. NDMAS also has methods for the management of the data output from VHTR simulation models and data generated from experiments designed to verify and validate the simulation codes. These simulation models represent the outcome of mathematical representation of VHTR components and systems. The methods data management approaches described herein will handle data that arise from experiment, simulation, and external sources for the main purpose of facilitating parameter estimation and model verification and validation (V&V). A model integration environment entitled ModelCenter is used to automate the storing of data from simulation model runs to the NDMAS repository. This approach does not adversely change the why computational scientists conduct their work. The method is to be used mainly to store the results of model runs that need to be preserved for auditing purposes or for display to the NDMAS web portal. This interim report demonstrates the currently development of NDMAS for Methods data and discusses data and its qualification that is currently part of NDMAS.

  18. Global Positioning System receiver evaluation results

    Energy Technology Data Exchange (ETDEWEB)

    Byrne, R.H.

    1993-09-01

    A Sandia project currently uses an outdated Magnavox 6400 Global Positioning System (GPS) receiver as the core of its navigation system. The goal of this study was to analyze the performance of the current GPS receiver compared to newer, less expensive models and to make recommendations on how to improve the performance of the overall navigation system. This paper discusses the test methodology used to experimentally analyze the performance of different GPS receivers, the test results, and recommendations on how an upgrade should proceed. Appendices contain detailed information regarding the raw data, test hardware, and test software.

  19. Results of Toxicity Studies Conducted on Outfall X-08 and Its Contributing Waste Streams, November 1999 - June 2000

    Energy Technology Data Exchange (ETDEWEB)

    Specht, W.L.

    2000-06-28

    This interim report summarizes the results of toxicity tests, Toxicity Identification Evaluations, and chemical analyses that have been conducted on SRS's NPDES Outfall X-08 and its contributing waste streams between November 1999 and June 2000.

  20. 32 CFR 776.82 - Interim suspension.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Interim suspension. 776.82 Section 776.82... Complaint Processing Procedures § 776.82 Interim suspension. (a) Where the Rules Counsel determines there is... interim suspension, pending completion of a professional responsibility investigation. The covered...

  1. 22 CFR 127.8 - Interim suspension.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Interim suspension. 127.8 Section 127.8 Foreign... Interim suspension. (a) The Managing Director of the Directorate of Defense Trade Controls or the Director of the Office of Defense Trade Controls Compliance is authorized to order the interim suspension of...

  2. Short report: interim safety results for a phase II trial measuring the integration of stereotactic ablative radiotherapy (SABR) plus surgery for early stage non-small cell lung cancer (MISSILE-NSCLC).

    Science.gov (United States)

    Palma, David A; Nguyen, Timothy K; Kwan, Keith; Gaede, Stewart; Landis, Mark; Malthaner, Richard; Fortin, Dalilah; Louie, Alexander V; Frechette, Eric; Rodrigues, George B; Yaremko, Brian; Yu, Edward; Dar, A Rashid; Lee, Ting-Yim; Gratton, Al; Warner, Andrew; Ward, Aaron; Inculet, Richard

    2017-01-27

    A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We report a mandated interim safety analysis for the first 10 patients who completed protocol treatment. Operable patients with biopsy-proven T1-2 N0 NSCLC were eligible. SABR was delivered using a risk-adapted fractionation (54Gy/3 fractions, 55/5 or 60/8). Surgical resection was planned 10 weeks later at a high-volume center (>200 lung cancer resections annually). Patients were imaged with dynamic positron emission tomography-computed tomography scans using 18F-fludeoxyglucose (18F-FDG-PET CT) and dynamic contrast-enhanced CT before SABR and again before surgery. Toxicity was recorded using CTCAE version 4.0. Twelve patients were enrolled between 09/2014 and 09/2015. Two did not undergo surgery, due to patient or surgeon preference; neither patient has developed toxicity or recurrence. For the 10 patients completing both treatments, median age was 70 (range: 54-76), 60% had T1 disease, and 60% had adenocarcinoma. Median FEV1 was 73% predicted (range: 54-87%). Median time to surgery post-SABR was 10.1 weeks (range: 9.3-15.6 weeks). Surgery consisted of lobectomy (n = 8) or wedge resection (n = 2). Median follow-up post-SABR was 6.3 months. After combined treatment, the rate of acute grade 3-4 toxicity was 10%. There was no post-operative mortality at 90 days. The small sample size included herein precludes any definitive conclusions regarding overall toxicity rates until larger datasets are available. However, these data may inform others who are designing or conducting similar trials. NCT02136355 . Registered 8 May 2014.

  3. Long-Term Safety and Effectiveness of Adalimumab for Moderate to Severe Psoriasis: Results from 7-Year Interim Analysis of the ESPRIT Registry.

    Science.gov (United States)

    Menter, Alan; Thaçi, Diamant; Wu, Jashin J; Abramovits, William; Kerdel, Francisco; Arikan, Dilek; Guo, Dianlin; Ganguli, Arijit; Bereswill, Mareike; Camez, Anne; Valdecantos, Wendell C

    2017-09-01

    ESPRIT (NCT00799877) is an ongoing 10-year international prospective observational registry evaluating the long-term safety and effectiveness of originator adalimumab in routine clinical practice for adult patients with chronic plaque psoriasis. Herein, we report the long-term safety, effectiveness, and patient-reported outcomes (PROs) following adalimumab treatment over the first 7 years of the ESPRIT registry. All treatment-emergent (All-TE) adverse events (AE) since the initial (first ever) dose of adalimumab were assessed. Physician Global Assessment (PGA) and PROs (PROs for US patients only) were evaluated during registry participation. As of 30 November 2015, 6051 patients in the ESPRIT registry were analyzed, representing 23,660.1 patient-years (PY) of overall adalimumab exposure. The incidence rates for All-TE serious AEs, serious infections, and malignancies were 4.4, 1.0, and 1.0 events per 100 PY (E/100PY), respectively. The standardized mortality ratio for TE deaths in the registry was 0.27 (95% CI 0.18-0.38). During the registry's first 7 years, PGA "clear" or "minimal" was achieved by >50% of patients at each annual visit, and among US patients, the mean improvement from baseline in different PROs was maintained. No new safety signals were identified during the first 7 years of the registry, and safety was consistent with the known safety profile of adalimumab. The number of TE deaths was below the expected rate. During the registry's first 7 years, most of the patients remained free of All-TE cardiovascular events, serious infections, and malignancy. As-observed effectiveness of adalimumab and improvements from baseline in PROs were maintained through 7 years of registry participation. Abbvie. ClinicalTrials.gov identifier, NCT00799877.

  4. The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.

    Science.gov (United States)

    Carotenuto, Anna; Rea, Raffaele; Traini, Enea; Fasanaro, Angiola Maria; Ricci, Giovanna; Manzo, Valentino; Amenta, Francesco

    2017-01-01

    Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD). Four clusters of BPSD have been described: mood disorders (depression, anxiety, and apathy), psychotic symptoms (delusions and hallucinations), aberrant motor behaviors (pacing, wandering, and other purposeless behaviors), and inappropriate behaviors (agitation, disinhibition, and euphoria). Most of them are attributed to acetylcholine deficiency. To evaluate if a higher amount of acetylcholine obtained by associating donepezil and choline alphoscerate might have a favorable effect on BPSD. BPSD were measured at baseline and after 24 months in 113 mild/moderate AD patients, included in the double-blind randomized trial ASCOMALVA, by the Neuropsychiatric Inventory (NPI). Two matched groups were compared: group A treated with donepezil (10 mg/day) plus choline alphoscerate (1200 mg/day), and group B treated with donepezil (10 mg/day) plus placebo. Data of NPI revealed a significant decrease of BPSD severity and distress of the caregiver in patients of group A compared with group B. Mood disorders (depression, anxiety and apathy) were significantly decreased in subjects treated with donepezil and choline alphoscerate, while their severity and frequency was increased in the other group. Patients treated with donepezil plus choline alphoscerate showed a lower level of behavioral disturbances than subjects treated with donepezil only, suggesting that the association can have beneficial effects.

  5. Evaluation of HY-2A Scatterometer Wind Vectors Using Data from Buoys, ERA-Interim and ASCAT during 2012–2014

    Directory of Open Access Journals (Sweden)

    Jianyong Xing

    2016-05-01

    Full Text Available The first Chinese operational Ku-band scatterometer on board Haiyang-2A (HY-2A, launched in August 2011, is designed for monitoring the global ocean surface wind. This study estimates the quality of the near-real-time (NRT retrieval wind speed and wind direction from the HY-2A scatterometer for 36 months from 2012 to 2014. We employed three types of sea-surface wind data from oceanic moored buoys operated by the National Data Buoy Center (NDBC and the Tropical Atmospheric Ocean project (TAO, the European Centre for Medium Range Weather Forecasting (ECMWF reanalysis data (ERA-Interim, and the advanced scatterometer (ASCAT to calculate the error statistics including mean bias, root mean square error (RMSE, and standard deviation. In addition, the rain effects on the retrieval winds were investigated using collocated Climate Prediction Center morphing method (CMORPH precipitation data. All data were collocated with the HY-2A scatterometer wind data for comparison. The quality performances of the HY-2A NRT wind vectors data (especially the wind speeds were satisfactory throughout the service period. The RMSEs of the HY-2A wind speeds relative to the NDBC, TAO, ERA-Interim, and ASCAT data were 1.94, 1.73, 2.25, and 1.62 m·s−1, respectively. The corresponding RMSEs of the wind direction were 46.63°, 43.11°, 39.93°, and 47.47°, respectively. The HY-2A scatterometer overestimated low wind speeds, especially under rainy conditions. Rain exerted a diminishing effect on the wind speed retrievals with increasing wind speed, but its effect on wind direction was robust at low and moderate wind speeds. Relative to the TAO buoy data, the RMSEs without rain effect were reduced to 1.2 m·s−1 and 39.68° for the wind speed direction, respectively, regardless of wind speed. By investigating the objective laws between rain and the retrieval winds from HY-2A, we could improve the quality of wind retrievals through future studies.

  6. Long-term effects of dredging operations program. Effects of sediment organic-matter composition on bioaccumulation of sediment organic contaminants: Interim results. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Brannon, J.M.; Price, C.B.; Reilly, F.J.; Pennington, J.C.; McFarland, V.A.

    1991-06-01

    The relationship of sediment-bound polychlorinated biphenyl (PCB) 153 and fluoranthene to bioaccumulation by worms and clams and the relationship of sediment-bound PCB 153 and fluoranthene to concentrations in the interstitial water were examined. Bioaccumulation by both worms and clams was observed in all sediments. Apparent preference factor (APF) values showed that steady state was reached between sediment-bound contaminants and organism lipid pools. The APF values of organisms were close to the theoretical value for both contaminants in all sediments. These results showed that sediment total organic carbon (TOC) in conjunction with octanol water partition coefficients of nonpolar organic contaminants is a viable approach for predicting bioaccumulation of such compounds by infaunal organisms. Actual concentrations of contaminants in interstitial water were either overestimated or underestimated by the relationship between TOC and humic + fulvic acid organic matter fractions and sediment contaminant concentrations. Prediction of interstitial water concentrations was not as successful as use of APFs. The lack of agreement between predicted and actual interstitial water results was due to factors such as the presence of interstitial water contaminants bounds to microparticulates and dissolved organic material and the kind of organic material in the sediment.

  7. INTERIM RESULTS FROM A STUDY OF THE IMPACTS OF TIN(II) BASED MERCURY TREATMENT IN A SMALL STREAM ECOSYSTEM: TIMS BRANCH, SAVANNAH RIVER SITE

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Bryan, L.; Mathews, T.

    2012-03-30

    Mercury (Hg) has been identified as a 'persistent, bioaccumulative and toxic' pollutant with widespread impacts throughout North America and the world (EPA. 1997a, 1997b, 1998a, 1998b, 2000). Although most of the mercury in the environment is inorganic Hg, a small proportion of total Hg is transformed through the actions of aquatic microbes into methylmercury (MeHg). In contrast to virtually all other metals, MeHg biomagnifies or becomes increasingly concentrated as it is transferred through aquatic food chains so that the consumption of mercury contaminated fish is the primary route of this toxin to humans. For this reason, the ambient water quality criterion (AWQC) for mercury is based on a fish tissue endpoint rather than an aqueous Hg concentration, as the tissue concentration (e.g., < 0.3 {mu}g/g fillet) is considered to be a more consistent indicator of exposure and risk (EPA, 2001). Effective mercury remediation at point-source contaminated sites requires an understanding of the nature and magnitude of mercury inputs, and also knowledge of how these inputs must be controlled in order to achieve the desired reduction of mercury contamination in biota necessary for compliance with AWQC targets. One of the challenges to remediation is that mercury body burdens in fish are more closely linked to aqueous MeHg than to inorganic Hg concentrations (Sveinsdottir and Mason 2005), but MeHg production is not easily predicted or controlled. At point-source contaminated sites, mercury methylation is not only affected by the absolute mercury load, but also by the form of mercury loaded. In addition, once MeHg is formed, the hydrology, trophic structure, and water chemistry of a given system affect how it is transformed and transferred through the food chain to fish. Decreasing inorganic Hg concentrations and loading may often therefore be a more achievable remediation goal, but has led to mixed results in terms of responses in fish bioaccumulation. A number of

  8. TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG.

    Science.gov (United States)

    Leong, Trevor; Smithers, B Mark; Haustermans, Karin; Michael, Michael; Gebski, Val; Miller, Danielle; Zalcberg, John; Boussioutas, Alex; Findlay, Michael; O'Connell, Rachel L; Verghis, Jaclyn; Willis, David; Kron, Tomas; Crain, Melissa; Murray, William K; Lordick, Florian; Swallow, Carol; Darling, Gail; Simes, John; Wong, Rebecca

    2017-08-01

    Postoperative chemoradiation and perioperative chemotherapy using epirubicin/cisplatin/5-fluorouracil (ECF) represent two standards of care for resectable gastric cancer. In the TOPGEAR (Trial Of Preoperative therapy for Gastric and Esophagogastric junction AdenocaRcinoma) trial, we hypothesized that adding preoperative chemoradiation to perioperative ECF will improve survival; however, the safety and feasibility of preoperative chemoradiation have yet to be determined. TOPGEAR is an international phase III trial in which patients with adenocarcinoma of the stomach were randomized to perioperative ECF alone or with preoperative chemoradiation. The ECF-alone group received three preoperative cycles of ECF, while the chemoradiation group received two cycles of preoperative ECF followed by chemoradiation. Both groups received three postoperative cycles of ECF. A planned interim analysis of the first 120 patients was conducted, and was reviewed by the Independent Data Safety Monitoring Committee to assess treatment compliance, toxicity/safety, and response rates. The proportion of patients who received all cycles of preoperative chemotherapy was 93% (ECF group) and 98% (chemoradiation group), while 65 and 53%, respectively, received all cycles of postoperative chemotherapy. Overall, 92% of patients allocated to preoperative chemoradiation received this treatment. The proportion of patients proceeding to surgery was 90% (ECF group) and 85% (chemoradiation group). Grade 3 or higher surgical complications occurred in 22% of patients in both groups. Furthermore, grade 3 or higher gastrointestinal toxicity occurred in 32% (ECF group) and 30% (chemoradiation group) of patients, while hematologic toxicity occurred in 50 and 52% of patients. These results demonstrate that preoperative chemoradiation can be safely delivered to the vast majority of patients without a significant increase in treatment toxicity or surgical morbidity.

  9. Radon measurements in schools: an interim report

    Energy Technology Data Exchange (ETDEWEB)

    1989-03-01

    The report provides school officials, groups such as Parent-Teacher Associations, and other interested person with interim information on how to measure radon in schools and what to do if elevated levels are found. The first sections of the document contain facts about radon and the health risks associated with radon exposure. The next sections summarize what is known about radon in schools and provide guidance for conducting radon measurements. The last sections describe how to interpret the measurement results and suggest techniques that can be used to reduce radon concentrations if elevated levels are found.

  10. Retention of long-term interim restorations with sodium fluoride enriched interim cement

    Science.gov (United States)

    Strash, Carolyn

    Purpose: Interim fixed dental prostheses, or "provisional restorations", are fabricated to restore teeth when definitive prostheses are made indirectly. Patients undergoing extensive prosthodontic treatment frequently require provisionalization for several months or years. The ideal interim cement would retain the restoration for as long as needed and still allow for ease of removal. It would also avoid recurrent caries by preventing demineralization of tooth structure. This study aims to determine if adding sodium fluoride varnish to interim cement may assist in the retention of interim restorations. Materials and methods: stainless steel dies representing a crown preparation were fabricated. Provisional crowns were milled for the dies using CAD/CAM technology. Crowns were provisionally cemented onto the dies using TempBond NE and NexTemp provisional cements as well as a mixture of TempBond NE and Duraphat fluoride varnish. Samples were stored for 24h then tested or thermocycled for 2500 or 5000 cycles before being tested. Retentive strength of each cement was recorded using a universal testing machine. Results: TempBond NE and NexTemp cements performed similarly when tested after 24h. The addition of Duraphat significantly decreased the retention when added to TempBond NE. NexTemp cement had high variability in retention over all tested time periods. Thermocycling for 2500 and 5000 cycles significantly decreased the retention of all cements. Conclusions: The addition of Duraphat fluoride varnish significantly decreased the retention of TempBond NE and is therefore not recommended for clinical use. Thermocycling significantly reduced the retention of TempBond NE and NexTemp. This may suggest that use of these cements for three months, as simulated in this study, is not recommended.

  11. Effectiveness Monitoring Report, MWMF Tritium Phytoremediation Interim Measures.

    Energy Technology Data Exchange (ETDEWEB)

    Hitchcock, Dan; Blake, John, I.

    2003-02-10

    This report describes and presents the results of monitoring activities during irrigation operations for the calendar year 2001 of the MWMF Interim Measures Tritium Phytoremediation Project. The purpose of this effectiveness monitoring report is to provide the information on instrument performance, analysis of CY2001 measurements, and critical relationships needed to manage irrigation operations, estimate efficiency and validate the water and tritium balance model.

  12. Are interim management statements redundant?

    OpenAIRE

    Schleicher, T.; Walker, Martin

    2015-01-01

    In 2004 the Transparency Directive increased the reporting frequency by mandating the Interim Management Statement (IMS). However, only nine years later, the EU announced that it was making quarterly reporting voluntary again arguing that IMSs are redundant as they are unlikely to contain any additional information not already required by the Market Abuse Directive (MAD). The current paper tests this argument empirically. For that it collects data on trading statements from a post-MAD pre-IMS...

  13. Review of evaluations of crushing results for the seedbed preparation

    Directory of Open Access Journals (Sweden)

    Siegfried Anisch

    2016-06-01

    Full Text Available For evaluating the work results of tillage operations today only inaccurate parameters are available which cannot be readily measured. Thus, evaluating and comparing the work results of machines and developing suitable sensors are difficult. At the Technical University of Dresden, till 1990, research projects for determining aggregate size composition of soil have been done. Based on this work, this study will show suggestions for measuring, displaying and evaluation of soil crushing results depending on tillage work conditions.

  14. Dobson, Brewer, ERA-40 and ERA-Interim original and merged total ozone data sets – evaluation of differences: a case study, Hradec Králové (Czech, 1961–2010

    Directory of Open Access Journals (Sweden)

    K. Vaníček

    2012-09-01

    Full Text Available Homogenized data series of total ozone measurements taken by the regularly and well calibrated Dobson and Brewer spectrophotometers at Hradec Králové (Czech and the data from the re-analyses ERA-40 and ERA-Interim were merged and compared to investigate differences between the particular data sets originated in Central Europe, the Northern Hemisphere (NH mid-latitudes. The Dobson-to-Brewer transfer function and the algorithm for approximation of the data from the re-analyses were developed, tested and applied for creation of instrumentally consistent and completed total ozone data series of the 50-yr period 1961–2010 of observations. This correction has reduced the well-known seasonal differences between Dobson and Brewer data below the 1% calibration limit of the spectrophotometers. Incorporation of the ERA-40 and ERA-Interim total ozone data on days with missing measurements significantly improved completeness and reliability of the data series mainly in the first two decades of the period concerned. Consistent behaviour of the original and corrected/merged data sets was found in the pre-ozone-hole period (1961–1985. In the post-Pinatubo (1994–2010 era the data series show seasonal differences that can introduce uncertainty in estimation of ozone recovery mainly in the winter-spring season when the effect of the Montreal Protocol and its Amendments is expected. All the data sets confirm substantial depletion of ozone also in the summer months that gives rise to the question about its origin. The merged and completed data series of total ozone will be further analyzed to quantify chemical ozone losses and contribution of natural atmospheric processes to the ozone depletion over the region. This case study points out the importance of selection and evaluation of the quality and consistency of the input data sets used in estimation of long-term ozone changes including recovery of the ozone layer over the selected areas. Data are available

  15. Burn site groundwater interim measures work plan.

    Energy Technology Data Exchange (ETDEWEB)

    Witt, Jonathan L. (North Wind, Inc., Idaho Falls, ID); Hall, Kevin A. (North Wind, Inc., Idaho Falls, ID)

    2005-05-01

    This Work Plan identifies and outlines interim measures to address nitrate contamination in groundwater at the Burn Site, Sandia National Laboratories/New Mexico. The New Mexico Environment Department has required implementation of interim measures for nitrate-contaminated groundwater at the Burn Site. The purpose of interim measures is to prevent human or environmental exposure to nitrate-contaminated groundwater originating from the Burn Site. This Work Plan details a summary of current information about the Burn Site, interim measures activities for stabilization, and project management responsibilities to accomplish this purpose.

  16. An economic evaluation of the ketogenic diet versus care as usual in children and adolescents with intractable epilepsy: An interim analysis.

    Science.gov (United States)

    de Kinderen, Reina J A; Lambrechts, Danielle A J E; Wijnen, Ben F M; Postulart, Debby; Aldenkamp, Albert P; Majoie, Marian H J M; Evers, Silvia M A A

    2016-01-01

    To gain insight into the cost-effectiveness of the ketogenic (KD) diet compared with care as usual (CAU) in children and adolescents with intractable epilepsy, we conducted an economic evaluation from a societal perspective, alongside a randomized controlled trial. Participants from a tertiary epilepsy center were randomized into KD (intervention) group or CAU (control) group. Seizure frequency, quality adjusted life years (QALYs), health care costs, production losses of parents and patient, and family costs were assessed at baseline and during a 4-month study period and compared between the intervention and control groups. The incremental cost-effectiveness ratios (ICERs) (i.e., cost per QALY and cost per responder), and cost-effectiveness acceptability curves (CEACs) were calculated and presented. In total, 48 children were included in the analyses of this study (26 KD group). At 4 months, 50% of the participants in the KD group had a seizure reduction ≥50% from baseline, compared with 18.2 of the participants in the CAU group. The mean costs per patient in the CAU group were €15,245 compared to €20,986 per patient in the KD group, resulting in an ICER of €18,044 per responder. We failed, however, to measure any benefits in terms of QALYs and therefore, the cost per QALY rise high above any acceptable ceiling ratio. It might be that the quality of life instruments used in this study were not sufficiently sensitive to detect changes, or it might be that being a clinical responder is not sufficient to improve a patient's quality of life. Univariate and multivariate sensitivity analyses and nonparametric bootstrapping were performed and demonstrated the robustness of our results. The results show that the KD reduces seizure frequency. The study did not find any improvements in quality of life and, therefore, unfavorable cost per QALY ratio's resulted. Wiley Periodicals, Inc. © 2015 International League Against Epilepsy.

  17. CD68+ cell count, early evaluation with PET and plasma TARC levels predict response in Hodgkin lymphoma.

    Science.gov (United States)

    Cuccaro, Annarosa; Annunziata, Salvatore; Cupelli, Elisa; Martini, Maurizio; Calcagni, Maria L; Rufini, Vittoria; Giachelia, Manuela; Bartolomei, Francesca; Galli, Eugenio; D'Alò, Francesco; Voso, Maria T; Leone, Giuseppe; Giordano, Alessandro; Larocca, Luigi M; Hohaus, Stefan

    2016-03-01

    Early response evaluation with [(18) F]fluordeoxyglucose (FDG) positron emission tomography after 2 cycles of chemotherapy (interim PET) has been indicated as the strongest predictor for outcome in classical Hodgkin lymphoma (HL). We studied the prognostic role of the number of tumor-infiltrating CD68+ cells and of the plasma levels of TARC (thymus and activation-regulated chemokine) in the context of interim PET in 102 patients with classical HL treated with Adriamycin, Bleomycin, Vinblastine, Dacarbazine (ABVD). After 2 ABVD cycles, interim PET according to Deauville criteria was negative (score 0-3) in 85 patients and positive (score 4-5) in 15 patients (2 patients technically not evaluable). TARC levels were elevated in 89% of patients at diagnosis, and decreased after 2 cycles in 82% of patients. Persistently elevated TARC levels in 18% of patients were significantly associated with a positive PET result (P = 0.007). Strong predictors for progression-free survival (PFS) were a negative interim PET (85% vs. 28%, P evaluation had no prognostic role. In multivariate analysis, interim PET, CD68+ cell counts and presence of B-symptoms were independently associated with PFS. We conclude that although TARC levels are a biomarker for early response evaluation, they cannot substitute for interim PET as outcome predictor in HL. The evaluation of CD68 counts and B-symptoms at diagnosis may help to identify low-risk patients regardless positive interim PET. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  18. Performance and evaluation of gas engine driven rooftop air conditioning equipment at the Willow Grove (PA) Naval Air Station. Interim report, 1992 cooling season

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, P.R.; Conover, D.R.

    1993-05-01

    In a field evaluation conducted for the US Department of Energy (DOE) Office of Federal Energy Management Program (FEMP), the Pacific Northwest Laboratory (PNL) examined the performance of a new US energy-related technology under the FEMP Test Bed Demonstration Program. The technology was a 15-ton natural gas engine driven roof top air conditioning unit. Two such units were installed on a naval retail building to provide space conditioning to the building. Under the Test Bed Demonstration Program, private and public sector interests are focused to support the installation and evaluation of new US technologies in the federal sector. Participating in this effort under a Cooperative Research and Development Agreement (CRADA) with DOE were the American Gas Cooling Center, Philadelphia Electric Company, Thermo King Corporation, and the US Naval Air Station at Willow Grove, Pennsylvania. Equipment operating and service data as well as building interior and exterior conditions were secured for the 1992 cooling season. Based on a computer assessment of the building using standard weather data, a comparison was made with the energy and operating costs associated with the previous space conditioning system. Based on performance during the 1992 cooling season and adjusted to a normal weather year, the technology will save the site $6,000/yr in purchased energy costs. An additional $9,000 in savings due to electricity demand ratchet charge reductions will also be realized. Detailed information on the technology, the installation, and the results of the technology test are provided to illustrate the advantages to the federal sector of using this technology. A history of the CRADA development process is also reported.

  19. DQO Summary Report for 105-N/109-N Interim Safe Storage Project Waste Characterization

    Energy Technology Data Exchange (ETDEWEB)

    T. A. Lee

    2005-09-15

    The DQO summary report provides the results of the DQO process completed for waste characterization activities for the 105-N/109-N Reactor Interim Safe Storage Project including decommission, deactivate, decontaminate, and demolish activities for six associated buildings.

  20. LANDFILLS AS BIOREACTORS: RESEARH AT THE OUTER LOOP LANDFILL, LOUISVILLE, KENTUCKY; FIRST INTERIM REPORT

    Science.gov (United States)

    Interim report resulting from a cooperative research and development agreement (CRADA) between US EP A's Officeof Research and Development - National Risk Management Research Laboratory and a n ongoing field demonstrationof municipal waste landfills being operated as bioreact...

  1. 19 CFR 356.18 - Interim sanctions.

    Science.gov (United States)

    2010-04-01

    ... ARTICLE 1904 OF THE NORTH AMERICAN FREE TRADE AGREEMENT Violation of a Protective Order or a Disclosure... administrative law judge to impose such sanctions. (b) The administrative law judge may impose interim sanctions... interim sanctions are a reasonable means for protecting the rights of the Department, authorized agency of...

  2. Fabrication of an Implant-Supported Fixed Interim Prosthesis Using a Duplicate Denture: An Alternative Technique.

    Science.gov (United States)

    Al-Thobity, Ahmad M

    2016-06-22

    The fabrication of an implant-supported fixed complete denture prosthesis involves multiple clinical and laboratory steps. One of the main steps is to provide the patient with an interim fixed prosthesis to evaluate the patient's esthetic and functional needs as well as to enhance the patient's psychology before proceeding to the definitive prosthesis. Different techniques for fabricating interim prostheses have been described in the literature. This report describes an alternative technique that uses a duplicate denture made of self-curing acrylic resin to fabricate an implant-supported fixed interim prosthesis. The interim prosthesis was later used as a blueprint for the definitive implant-supported hybrid prosthesis. © 2016 by the American College of Prosthodontists.

  3. U.S. DOE FreedomCAR and Vehicle Technologies Advanced Technology Development Program for Lithium-Ion Batteries: Gen 2 Performance Evaluation Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Jon P. Christophersen; Chet Motloch; Ira D. Bloom; Vince Battaglia; Ganesan Nagasubramanian; Tien Q. Duong

    2003-02-01

    The Advanced Technology Development Program is currently evaluating the performance of the second generation of Lithium-ion cells (i.e., Gen 2 cells). The 18650-size Gen 2 cells consist of a baseline chemistry and one variant chemistry. These cells were distributed over a matrix consisting of three states-of-charge (SOC) (60, 80, and 100% SOC), four temperatures (25, 35, 45, and 55°C), and three life tests (calendar-, cycle-, and accelerated-life). The calendar-life cells are clamped at an opencircuit voltage corresponding to 60% SOC and undergo a once-per-day pulse profile. The cycle-life cells are continuously pulsed using a profile that is centered around 60% SOC. The accelerated-life cells are following the calendar-life test procedures, but using the cycle-life pulse profile. Life testing is interrupted every four weeks for reference performance tests (RPTs), which are used to quantify changes in capacity, resistance, and power. The RPTs consist of a C1/1 and C1/25 static capacity tests, a low-current hybrid pulse power characterization test, and electrochemical impedance spectroscopy at 60% SOC. Capacity-, power-, and electrochemical impedance spectroscopy-based performance results are reported.

  4. Decadal variations in atmospheric water vapor time series estimated using GNSS, ERA-Interim, and synoptic data

    Science.gov (United States)

    Alshawaf, Fadwa; Dick, Galina; Heise, Stefan; Balidakis, Kyriakos; Schmidt, Torsten; Wickert, Jens

    2017-04-01

    Ground-based GNSS (Global Navigation Satellite Systems) have efficiently been used since the 1990s as a meteorological observing system. Recently scientists used GNSS time series of precipitable water vapor (PWV) for climate research although they may not be sufficiently long. In this work, we compare the trend estimated from GNSS time series with that estimated from European Center for Medium-RangeWeather Forecasts Reanalysis (ERA-Interim) data and meteorological measurements.We aim at evaluating climate evolution in Central Europe by monitoring different atmospheric variables such as temperature and PWV. PWV time series were obtained by three methods: 1) estimated from ground-based GNSS observations using the method of precise point positioning, 2) inferred from ERA-Interim data, and 3) determined based on daily surface measurements of temperature and relative humidity. The other variables are available from surface meteorological stations or received from ERA-Interim. The PWV trend component estimated from GNSS data strongly correlates (>70%) with that estimated from the other data sets. The linear trend is estimated by straight line fitting over 30 years of seasonally-adjusted PWV time series obtained using the meteorological measurements. The results show a positive trend in the PWV time series with an increase of 0.2-0.7 mm/decade with a mean standard deviations of 0.016 mm/decade. In this paper, we present the results at three GNSS stations. The temporal increment of the PWV correlates with the temporal increase in the temperature levels.

  5. Oil condition sensor. Interim report; Oelzustandssensor. Zwischenbericht

    Energy Technology Data Exchange (ETDEWEB)

    Hartwig, S.; Jaegle, M. [Fraunhofer-Inst. fuer Physikalische Messtechnik, Freiburg (Germany); Rademacher, S.; Schultheis, W. [BEDIA, Leinburg (Germany)

    2003-07-01

    In the summer of 2000 the Fraunhofer Institute for physical measuring technology was tasked by the FW with a study to evaluate various measurement principles for the development of oil condition sensors. In the frame of this study, four new sensor principles were proposed for the use in engine oil. Apart from an optical measurement method (online-ATR -spectroscopy) the measurement of sensitive material - in particular metal oxides and zeolites - within the engine oil as well as a method for the determination of electrode transition resistances, which falsify the measure values, were tested. The last method has been adapted from the field of microelectronics (TLM approach, transmission line model). In the frame of the current project ''Oil condition sensor'' the feasibility of these approaches is supposed to be tested. The plan is to construct sensors for these four measurement principles, to manufacture them and to carry out the measurements. A measurement stand was especially set-up to for the last purpose of this project, which allows adjusting the operating conditions within the engine in terms of pressure, flow and temperature course as realistic as possible. This interim report provides an overview of the results, which have been obtained so far. (orig.) [German] In einer von der FW in Auftrag gegebenen Studie wurde das Fraunhofer-Institut fuer Physikalische Messtechnik im Sommer 2000 beauftragt, verschiedene Messprinzipien fuer die Entwicklung eines Oelzustandssensors zu evaluieren. Als Ergebnis wurden im Rahmen dieser Studie vier fuer den Einsatz im Motoroel neuartige Sensorprinzipien vorgeschlagen. Neben einem optischen Messverfahren (online-ATR-Spektroskopie) waren dies die Vermessung sensitiver Materialien - insbesondere Metalloxide und Zeolithe - im Motoroel, sowie ein aus der Mikroelektronik adaptiertes Verfahren zur Bestimmung von messwertverfaelschenden Elektrodenuebergangswiderstaenden (TLM-Ansatz, Transmission-Line Model). Im

  6. Vet Centers. Interim final rule.

    Science.gov (United States)

    2015-08-04

    The Department of Veterans Affairs (VA) is amending its medical regulation that governs Vet Center services. The National Defense Authorization Act for Fiscal Year 2013 (the 2013 Act) requires Vet Centers to provide readjustment counseling services to broader groups of veterans, members of the Armed Forces, including a member of a reserve component of the Armed Forces, and family members of such veterans and members. This interim final rule amends regulatory criteria to conform to the 2013 Act, to include new and revised definitions.

  7. Non-Formal Educator Use of Evaluation Results

    Science.gov (United States)

    Baughman, Sarah; Boyd, Heather H.; Franz, Nancy K.

    2012-01-01

    Increasing demands for accountability in educational programming have resulted in increasing calls for program evaluation in educational organizations. Many organizations include conducting program evaluations as part of the job responsibilities of program staff. Cooperative Extension is a complex organization offering non-formal educational…

  8. The ASCD Healthy School Communities Project: Formative Evaluation Results

    Science.gov (United States)

    Valois, Robert F.; Lewallen, Theresa C.; Slade, Sean; Tasco, Adriane N.

    2015-01-01

    Purpose: The purpose of this paper is to report the formative evaluation results from the Association for Supervision and Curriculum Development Healthy School Communities (HSC) pilot project. Design/methodology/approach: This study utilized 11 HSC pilot sites in the USA (eight sites) and Canada (three sites). The evaluation question was…

  9. Waste Encapsulation and Storage Facility interim operational safety requirements

    CERN Document Server

    Covey, L I

    2000-01-01

    The Interim Operational Safety Requirements (IOSRs) for the Waste Encapsulation and Storage Facility (WESF) define acceptable conditions, safe boundaries, bases thereof, and management or administrative controls required to ensure safe operation during receipt and inspection of cesium and strontium capsules from private irradiators; decontamination of the capsules and equipment; surveillance of the stored capsules; and maintenance activities. Controls required for public safety, significant defense-in-depth, significant worker safety, and for maintaining radiological consequences below risk evaluation guidelines (EGs) are included.

  10. Succesvol interim-management : Meesterschap in een tijdelijke context

    NARCIS (Netherlands)

    Schaveling, J.

    2010-01-01

    Als flexibele optie om het management van organisaties aan te vullen, past interim-management helemaal in deze tijd. Maar wat maakt een interim-managementopdracht succesvol? ‘Succesvol interim-management’ is een studie naar de succesfactoren van interim-management. In de literatuur worden

  11. Scoren met interim-management : De weg naar tevreden opdrachtgevers

    NARCIS (Netherlands)

    Schaveling, J.

    2010-01-01

    Tegenwoordig kijkt niemand in organisaties meer op van de aanwezigheid van interim-managers. Interim-management biedt dé flexibiliteit om het management van organisaties aan te vullen. Maar wat maakt interim-managementopdrachten succesvol? Daarover gaat 'Scoren met interim-management: de weg naar

  12. 46 CFR 309.101 - Amendment of interim binders.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Amendment of interim binders. 309.101 Section 309.101... INSURANCE § 309.101 Amendment of interim binders. The interim binder for a vessel whose stated valuation is... after the attachment of the insurance under the interim binder to which such valuation applies...

  13. Toward a risk assessment of the spent fuel and high-level nuclear waste disposal system. Risk assessment requirements, literature review, methods evaluation: an interim report

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, L.D.; Hill, D.; Rowe, M.D.; Stern, E.

    1986-04-01

    This report provides background information for a risk assessment of the disposal system for spent nuclear fuel and high-level radioactive waste (HLW). It contains a literature review, a survey of the statutory requirements for risk assessment, and a preliminary evaluation of methods. The literature review outlines the state of knowledge of risk assessment and accident consequence analysis in the nuclear fuel cycle and its applicability to spent fuel and HLW disposal. The survey of statutory requirements determines the extent to which risk assessment may be needed in development of the waste-disposal system. The evaluation of methods reviews and evaluates merits and applicabilities of alternative methods for assessing risks and relates them to the problems of spent fuel and HLW disposal. 99 refs.

  14. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  15. Installation and evaluation of a nuclear power plant operator advisor based on artificial intelligence technology. Interim progress report and second year development plan

    Energy Technology Data Exchange (ETDEWEB)

    Hajek, B.K.; Miller, D.W.

    1989-06-20

    This report discusses the following topics on a Nuclear Power Plant operator advisor based on artificial Intelligence Technology; Workstation conversion; Software Conversion; V&V Program Development Development; Simulator Interface Development; Knowledge Base Expansion; Dynamic Testing; Database Conversion; Installation at the Perry Simulator; Evaluation of Operator Interaction; Design of Man-Machine Interface; and Design of Maintenance Facility.

  16. Interim main report of the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Hedin, Allan (ed.) [and others

    2004-08-01

    This document is an interim report on the safety assessment SR-Can (SR in the acronym stands for Safety Report and Can is short for canister). The final SR-Can report will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of the present interim report is to demonstrate the methodology for safety assessment so that it can be reviewed before it is used in a license application. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. Preliminary data from the Forsmark site, presently being investigated by SKB as one of the candidate for a KBS-3 repository are used to some extent as examples. However, the collected data are yet too sparse to allow an evaluation of safety for this site. An important aim of this report is to demonstrate the proper handling of requirements on the safety assessment in applicable regulations. Therefore, regulations issued by the Swedish Nuclear Power Inspectorate and the Swedish Radiation Protection Authority are duplicated in an Appendix. The principal acceptance criterion requires that 'the annual risk of harmful effects after closure does not exceed 10{sup -6} for a representative individual in the group exposed to the greatest risk'. 'Harmful effects' refer to cancer and hereditary effects. Following the introductory chapter 1, this report outlines the methodology for the SR-Can assessment in chapter 2, and presents in chapters 3, 4 and 5 the initial state of the system and the plans and methods for handling external influences and internal processes, respectively. Function indicators are introduced in chapter 6 and a preliminary evaluation of these is given in chapter 7. The material presented in the first seven chapters is utilised in the scenario selection

  17. One-year results of a prospective randomized, evaluator-blinded, multicenter study comparing TVT and TVT Secur.

    OpenAIRE

    Andrada Hamer, Maria; Larsson, Per-Göran; Teleman, Pia; Bergqvist, Christina Eten; Persson, Jan

    2012-01-01

    INTRODUCTION AND HYPOTHESIS: The aim of this prospective randomized multicenter study was to compare retropubic tension-free vaginal tape (TVT) with TVT Secur in terms of efficacy and safety. METHODS: We set out to enrol 280 stress urinary incontinent (SUI) women with a half-time interim analysis of short-term cure and adverse events. The short-term results have previously been published. Of the133 randomized women, 125 underwent surgery, and 121 (TVT n = 61, TVT Secur n = 60)...

  18. WP5 Evaluation: D54-D55 Evaluation Results V2 (V3)

    NARCIS (Netherlands)

    Van Rosmalen, Peter

    2011-01-01

    Van Rosmalen, P. (2010, 19 May). WP5 Evaluation: D54-D55 Evaluation Results V2 (V3). Presentation at idSpace Final Review, Heerlen, The Netherlands: Open University of the Netherlands. idSpace-project.

  19. Results of a Research Evaluating Quality of Computer Science Education

    Science.gov (United States)

    Záhorec, Ján; Hašková, Alena; Munk, Michal

    2012-01-01

    The paper presents the results of an international research on a comparative assessment of the current status of computer science education at the secondary level (ISCED 3A) in Slovakia, the Czech Republic, and Belgium. Evaluation was carried out based on 14 specific factors gauging the students' point of view. The authors present qualitative…

  20. GPS water vapor and its comparison with radiosonde and ERA-Interim data in Algeria

    Science.gov (United States)

    Namaoui, Houaria; Kahlouche, Salem; Belbachir, Ahmed Hafid; Van Malderen, Roeland; Brenot, Hugues; Pottiaux, Eric

    2017-05-01

    Remote sensing of atmospheric water vapor using global positioning system (GPS) data has become an effective tool in meteorology, weather forecasting and climate research. This paper presents the estimation of precipitable water (PW) from GPS observations and meteorological data in Algeria, over three stations located at Algiers, Bechar and Tamanrasset. The objective of this study is to analyze the sensitivity of the GPS PW estimates for the three sites to the weighted mean temperature ( T m), obtained separately from two types of T m- T s regression [one general, and one developed specifically for Algeria ( T s stands for surface temperature)], and calculated directly from ERA-Interim data. The results show that the differences in T m are of the order of 18 K, producing differences of 2.01 mm in the final evaluation of PW. A good agreement is found between GPS-PW and PW calculated from radiosondes, with a small mean difference with Vaisala radiosondes. A comparison between GPS and ERA-Interim shows a large difference (4 mm) in the highlands region. This difference is possibly due to the topography. These first results are encouraging, in particular for meteorological applications in this region, with good hope to extend our dataset analysis to a more complete, nationwide coverage over Algeria.

  1. Arsenic Removal from Drinking Water by Adsorptive Media U.S. EPA Demonstration Project at Upper Bodfish in Lake Isabella, CA Interim Evaluation Report

    Science.gov (United States)

    This report documents the activities performed during and the results obtained from the first 10 months of system operation of an arsenic (As) and uranium (U) removal technology being demonstrated at Upper Bodfish in Lake Isabella, CA. The objectives of the project are to evalua...

  2. ARSENIC REMOVAL FROM DRINKING WATER BY ADSORPTIVE MEDIA. U.S. EPA DEMONSTRATION PROJECT AT SOUTH TRUCKEE MEADOWS GENERAL IMPROVEMENT DISTRICT (STMIG), NV. INTERIM EVALUATION REPORT

    Science.gov (United States)

    This report documents the activities performed during and the results obtained from the first 32 weeks of operation of an arsenic and antimony removal technology currently being demonstrated at the South Truckee Meadows General Improvement District (STMGID) in Washoe County, NV. ...

  3. Implementing a strategy to promote lifelong learning in the primary care workforce: an evaluation of leadership roles, change management approaches, interim challenges and achievements.

    Science.gov (United States)

    McLaren, Susan; Woods, Leslie; Boudioni, Markella; Lemma, Ferew; Tavabie, Abdol

    2008-01-01

    To identify and explore leadership roles and responsibilities for implementing the workforce development strategy; to identify approaches used to implement and disseminate the strategy; and to identify and explore challenges and achievements in the first 18 months following implementation. A formative evaluation with qualitative methods was used. Documentary analysis, interviews (n = 29) and two focus groups (n = 12) were conducted with a purposive sample of individuals responsible for strategy implementation. Data were transcribed and analysed thematically using framework analysis. Regional health area in Kent, Surrey and Sussex: 24 primary care trusts (PCTs) and 900 general practices. Primary care workforce tutors, lifelong learning advisors, GP tutors, patch associate GP deans and chairs of PCT education committees all had vital leadership roles, some existing and others newly developed. Approaches used to implement the strategy encompassed working within and across organisational boundaries, communication and dissemination of information. Challenges encountered by implementers were resistance to change - evident in some negative attitudes to uptake of training and development opportunities - and role diversity and influence. Achievements included successes in embedding appraisal and protected learning time, and changes in educational practices and services. The use of key leadership roles and change-management approaches had brought about early indications of positive transition in lifelong learning cultures.

  4. Controversies on the prognostic value of interim FDG-PET in advanced-stage Hodgkin lymphoma.

    Science.gov (United States)

    Adams, Hugo J A; Kwee, Thomas C

    2016-12-01

    Hodgkin lymphoma, even in advanced-stage, is a highly curable malignancy, but treatment is associated with short-term toxicity and long-term side effects. Early predictive markers are required to identify those patients who do not require the full-length standard therapy (and thus qualify for therapy de-escalation) and those patients who will not be cured by standard therapy (and thus qualify for therapy escalation). Multiple trials have assessed the value of (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) after a few cycles of chemotherapy (also known as 'interim FDG-PET') in predicting outcome in advanced-stage Hodgkin lymphoma. Furthermore, multiple interim FDG-PET-adapted trials, in which patients with positive interim FDG-PET scans are assigned to escalated therapies, and patients with negative interim FDG-PET scans are assigned to de-escalated therapies, have recently been published or are currently ongoing, with generally heterogeneous results. The present article reports the currently available evidence (and controversies) on the prognostic value of interim FDG-PET in advanced-stage Hodgkin lymphoma in patients with positive and negative interim FDG-PET findings following continuation of standard chemotherapy or escalated/de-escalated therapy. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. [Evaluation and results of ablative therapies in prostate cancer].

    Science.gov (United States)

    Renard-Penna, R; Sanchez-Salas, R; Barret, E; Cosset, J M; de Vergie, S; Sapetti, J; Ingels, A; Gangi, A; Lang, H; Cathelineau, X

    2017-11-01

    To perform a state of the art about methods of evaluation and present results in ablative therapies for localized prostate cancer. A review of the scientific literature was performed in Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of keywords. Publications obtained were selected based on methodology, language and relevance. After selection, 102 articles were analysed. Analyse the results of ablative therapies is presently difficult considering the heterogeneity of indications, techniques and follow-up. However, results from the most recent and homogeneous studies are encouraging. Oncologically, postoperative biopsies (the most important criteria) are negative (without any tumor cells in the treated area) in 75 to 95%. Functionally, urinary and sexual pre-operative status is spared (or recovered early) in more than 90% of the patients treated. More and more studies underline also the correlation between the results and the technique used considering the volume of the gland and, moreover, the "index lesion" localization. The post-treatment pathological evaluation by biopsies (targeted with MRI or, perhaps in a near future, with innovative ultrasonography) is the corner stone of oncological evaluation of ablative therapies. Ongoing trials will allow to standardize the follow-up and determine the best indication and the best techniques in order to optimize oncological and functional results for each patient treated. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  6. Interim Evaluation of the Tier 1 Program (Secondary 1 Curriculum of the Project P.A.T.H.S.: First Year of the Full Implementation Phase

    Directory of Open Access Journals (Sweden)

    Daniel T. L. Shek

    2008-01-01

    Full Text Available To understand the implementation quality of the Tier 1 Program (Secondary 1 Curriculum of the Project P.A.T.H.S. (Positive Adolescent Training through Holistic Social Programmes in the full implementation phase, 100 schools were randomly selected to participate in personal and/or telephone interviews regarding the quality of the implementation process of the Tier 1 Program. In the interviews, the participants described the responses of the students to the program, the perceived benefits of the program, the perceived good aspects of the program, and the areas requiring improvement, difficulties encountered in the implementation process, and perceived attributes of the worker-support scheme (“Co-Walker Scheme”. Results showed that most workers perceived that the students had positive responses to the program and the program was beneficial to the students. They also identified several good aspects in the program, although negative comments on the program design and difficulties in the implementation process were also recorded. Roughly half of the respondents had positive comments on the “Co-Walker Scheme”. In sum, the respondents generally regarded the program as beneficial to the students and they were satisfied with the Tier 1 Program (Secondary 1 Curriculum in the full implementation phase, although some implementation difficulties were also expressed.

  7. Combining Results From Multiple Evaluations of the Same Measurand.

    Science.gov (United States)

    Kessel, Rüdiger; Kacker, Raghu N; Sommer, Klaus-Dieter

    2011-01-01

    According to the Guide to the Expression of Uncertainty in Measurement (GUM), a result of measurement consists of a measured value together with its associated standard uncertainty. The measured value and the standard uncertainty are interpreted as the expected value and the standard deviation of a state-of-knowledge probability distribution attributed to the measurand. We discuss the term metrological compatibility introduced by the International Vocabulary of Metrology, third edition (VIM3) for lack of significant differences between two or more results of measurement for the same measurand. Sometimes a combined result of measurement from multiple evaluations of the same measurand is needed. We propose an approach for determining a combined result which is metrologically compatible with the contributing results.

  8. Travinfor Evaluation: Value Added Reseller (var) Study Phase 1 Results

    OpenAIRE

    Loukakos, D.; Hall, R.; Weissenberger, S.; Yim, Y. B.

    1996-01-01

    TravInfo is a Field Operational Test (FOT) in advanced traveler information systems (ATIS) for the San Francisco Bay Area sponsored by the Federal Highway Administration (FHWA). The project involves a public/private partnership which seeks to compile, integrate and broadly disseminate timely and accurate multi-modal traveler information through commercial products and services. This working paper is part of the Technology Element of the TravInfo evaluation. It presents the results of the "bef...

  9. Review of SKB's interim report of SR-Can: SKI's and SSI's evaluation of SKB's up-dated methodology for safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjoern; Moberg, Leif; Wiebert, Anders; Xu Shulan [Swedish Radiation Protection Authority, Stockholm (Sweden); Stroemberg, Bo; Kautsky, Fritz; Lilja, Christina; Simic, Eva; Sundstroem, Benny; Toverud, Oeivind [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2005-07-01

    This report presents the findings of a review of the Swedish Nuclear Fuel and Waste Management Co.'s (SKB) interim report of the safety assessment SR-Can (SKB TR 04-11), conducted by the Swedish Radiation Protection Authority (SSI) and the Swedish Nuclear Power Inspectorate (SKI). SKB's interim report describes and exemplifies the safety assessment methodology that SKB plans to use in the oncoming licence applications for an encapsulation plant and a final repository for spent nuclear fuel. The authorities' review takes into account the findings of an international peer review of SKB's interim report. The authorities conclude that SKB has improved its safety assessment methodology in several aspects compared to earlier safety reports. Among other things the authorities commend SKB for giving a comprehensive account of relevant regulations and guidance, and for the systematic approach to identification and documentation of features, events and processes that need to be considered in the safety assessment. However, the authorities also conclude that important parts of SKB's method need to be further developed before they are mature enough to be used as a basis for a license application. The authorities' overall assessment is summarised in chapter 8 of this report.

  10. Evaluation of the results of coal jigging process

    Directory of Open Access Journals (Sweden)

    Surowiak Agnieszka

    2017-01-01

    Full Text Available Quality of applied hard coal fuel to combustion processes influence significantly on process efficiency and effects of its influence on surrounding environment. It is particularly important issue in time of Clean Coal Technologies (CTW. The paper presents the analysis of hard coal beneficiation in a jig for getting an optimal recovery of useful fraction in concentrate (combustible matter and not useful fraction (ash and sulfur. On the basis of industrial sampling of coal dust jig the density analysis of collected samples of concentrate and tailings was performed in laboratory conditions. In separated fractions of separation products the yields of products were calculated and the contents of ash and total sulfur were marked in them. On the basis of the results of density and chemical analyzes, separation products balance and appropriate calculations the Fuerstenau beneficiation curves were plotted which allowed to evaluate process and compare results of beneficiation of material containing various components. This is a different approach to evaluation of coal beneficiation effects, so far being used mainly for multi-component metals ores. Furthermore, the evaluation of separation preciseness on the basis of separation curves and factors was done and the statistical analysis of mutual correlations of analyzed parameters was done.

  11. Physical activity across the curriculum: year one process evaluation results

    Directory of Open Access Journals (Sweden)

    Sullivan Debra K

    2008-07-01

    Full Text Available Abstract Background Physical Activity Across the Curriculum (PAAC is a 3-year elementary school-based intervention to determine if increased amounts of moderate intensity physical activity performed in the classroom will diminish gains in body mass index (BMI. It is a cluster-randomized, controlled trial, involving 4905 children (2505 intervention, 2400 control. Methods We collected both qualitative and quantitative process evaluation data from 24 schools (14 intervention and 10 control, which included tracking teacher training issues, challenges and barriers to effective implementation of PAAC lessons, initial and continual use of program specified activities, and potential competing factors, which might contaminate or lessen program effects. Results Overall teacher attendance at training sessions showed exceptional reach. Teachers incorporated active lessons on most days, resulting in significantly greater student physical activity levels compared to controls (p Conclusion In the first year of the PAAC intervention, process evaluation results were instrumental in identifying successes and challenges faced by teachers when trying to modify existing academic lessons to incorporate physical activity.

  12. [Evaluation of the results of lumbar sympathectomy using hemodynamic variables].

    Science.gov (United States)

    Ley Pozo, J; Vega Gómez, M E; Ochoa Bizet, M; Cardona Alvarez, M; Romero Valdés, A; Fernández Boloña, A; Gutiérrez Jiménez, O

    1990-01-01

    In order to evaluate the results of the lumbar sympathectomy, we studied 49 patients in the National Institute of Angiology and Vascular Surgery during two years. The hemodynamic tests were performed the day before and one month after the surgical intervention; they included: skin thermometry, measurement of arterial blood flow and resistance in the foot and in the leg, and reactive hyperemia under photoplethysmographic control. Objectively, it could be seen only an increase in the distal skin temperature and an increase of skin blood flow after this treatment.

  13. Tactical Automated Security System (TASS) operational concept field evaluation results

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, D. [Electronic Systems Center, Hanscom AFB, MA (United States); Vinkels, G. [Horizons Technology, Inc., Billerica, MA (United States)

    1995-12-31

    The worldwide quick reaction deployment concept for the Tactical Automated Security System (TASS) was demonstrated to have great value in a base defense operational exercise. TASS equipment was deployed and used as part of the Foal Eagle 94 exercise at Kunsan AB, Korea. The TASS functions of detection, data communication, annunciation, assessment and portable power were evaluated using prototype equipment. The results of the TASS operation during the exercise was very impressive. The friendly forces quickly incorporated the TASS equipment into their defensive operations and were able to intercept and neutralize approximately 80% of the aggressor force penetration attempts at the defensive perimeter.

  14. Some quantitative evaluations on finite difference local and global results

    Directory of Open Access Journals (Sweden)

    Costamagna Eugenio

    2016-06-01

    Full Text Available Refined Schwarz-Christoffel (SC conformal transformations allow us to perform reliable quantitative evaluation of the accuracy of local computation of electric and magnetic fields with limited effort, which can be useful to complement well known comparisons of global results. In this paper some examples are presented for mesh point potentials obtained by means of finite difference (FD methods, but it is possible that similar considerations will be useful in the case of finite element methods (FEM or meshless computations too.

  15. Steel Containment Vessel Model Test: Results and Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Costello, J.F.; Hashimote, T.; Hessheimer, M.F.; Luk, V.K.

    1999-03-01

    A high pressure test of the steel containment vessel (SCV) model was conducted on December 11-12, 1996 at Sandia National Laboratories, Albuquerque, NM, USA. The test model is a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of an improved Mark II boiling water reactor (BWR) containment. A concentric steel contact structure (CS), installed over the SCV model and separated at a nominally uniform distance from it, provided a simplified representation of a reactor shield building in the actual plant. The SCV model and contact structure were instrumented with strain gages and displacement transducers to record the deformation behavior of the SCV model during the high pressure test. This paper summarizes the conduct and the results of the high pressure test and discusses the posttest metallurgical evaluation results on specimens removed from the SCV model.

  16. Evaluation of the screening test results before marriage

    Directory of Open Access Journals (Sweden)

    Süleyman Durmaz

    2011-09-01

    Full Text Available Objectives: Human immunodeficiency virus (HIV, Hepatitis B and Hepatitis C viruses and Treponema pallidum are parenterally and sexually transmitted infection agents. Screening test is made before marriage to pre-marital couples legally under the relevant legislation and legal procedures in our country; applicants are evaluated in terms of sexually transmitted diseases. The aim of this study is to evaluate pre-marital test results for HBsAg, anti-HCV, anti-HIV I/II and Treponema pallidum.Materials and methods: To make screening test before marriage, randomized 117 patients who were applied to Kızıltepe General Hospital of Infectious Diseases and Clinical Microbiology, were included in this study between January 2011 and March 2011. Of these patients, 64 were women (average age 24.7±5.7, and 55 were males (mean age 24.7±4.7. HBsAg, anti-HCV and anti-HIV I/II tests of the patients were studied by macro-ELISA device (ECIQ Vitros, Ortho Clinical Diagnostics, USA, screening of anti-Treponema pallidum IgG, IgA and IgM antibodies were studied by immunochromatographic rapid test (syphilis syphilis 3.0, Standard Diagnostics, inc. Korea.Results: Of the 119 patients, five patients (4.2% were positive for HBsAg (3 male and 2 female. Anti-HCV, anti-HIV I/II and anti-Treponema pallidum antibodies were negative in all patients.Conclusion: HBsAg test result which was obtained in present study has been found consistent with HBsAg positivity rate in our region. As a result of screening test that was done before marriage will continue to believe that the increased importance of the prevention of sexually transmitted diseases. J Clin Exp Invest 2011; 2 (3: 292-294.

  17. Evaluation of cervicovaginal smear results at postmenopausal period

    Directory of Open Access Journals (Sweden)

    Sefa Kelekci

    2016-02-01

    Full Text Available This study evaluates the statistical analysis of cervicovaginal smear results at postmenopausal period accompanied by literature. Cervicovaginal smear results of 894 postmenopausal women were evaluated retrospectively according to the 2001 Bethesda system (BS in Adana Numune Training and Research Hospital of Obstetrics and Gynecology Clinic from 2007–2010. The study found, normal results on 287 patients (32.1%, benign findings on 556 patients (62.2%, abnormal epithelial cell changes on 48 patients (5.36% and malignant changes on 3 patients (0.33%. The abnormal epithelial changes were observed to be atypical cells of undetermined significance (ASC-US for 22 patients (2.46%, low-grade squamous intraepithelial lesion (LSIL for 11 patients (1.23%, high-grade squamous intraepithelial lesion(HSIL for 7 patients (0.78%, findings that cannot exclude a high-grade squamous intraepithelial lesion (ASC-H for 6 patients (0.55% and atypical glandular cells-not otherwise specified (AGC-NOS for 2 patients (0.22%. Malignant results were 2 squamous cell carcinomas (SCC (0.22% and 1 adenocarcinoma (ACC (0.11%. Cervical cancer screening programs should be expanded and Pap smear screening should be applied to all postmenopausal women. The longer time span involved from premalignant lesions to cancer improves our chance for the diagnosis and treatment. As the incidence of invasive cancer increases in menopausal period, gynecological smear examination and regular check-up are crucial. A high rate of abnormalities of epithelial cells was detected in this study.

  18. Sustainable revitalization of brownfield lands – possibilities of interim utilization in the form of urban community gardens

    Directory of Open Access Journals (Sweden)

    Adorján Anna

    2015-12-01

    Full Text Available Our PhD researches include brownfield revitalization,1 the application of the methods of interim utilizations on greeneries,2 and the formation background and potential of community gardens.3 We compared our systems of criteria in hope of extensive research conclusions. In order to trace the urban development possibilities in Budapest, we analysed brownfield revitalizations where the interim utilizations included allotment gardens, too. We concluded that such developments are likely to create environmental and social added value. Early results of the valorization process are important by themselves, but the perpetuation of interim land utilization holds even greater values.

  19. Interim-Management: A paradox for leadership research?

    OpenAIRE

    Bruns, Jürgen; Kabst, Rüdiger

    2005-01-01

    The study focuses on Interim-Management as a so far rarely discussed phenomenon of the flexible firm. Contradicting popular leadership perception, the authors argue that Interim-Management does not constitute a leadership paradox but can be explained by established organization theory. In particular, transaction cost economics as well as resource-based view help explain the utilization of Interim-Management. Furthermore, the authors show that Interim-Management constitutes a response to reduc...

  20. Uniform presentation of process evaluation results facilitates the evaluation of complex interventions: development of a graph.

    Science.gov (United States)

    Bakker, Franka C; Persoon, Anke; Schoon, Yvonne; Olde Rikkert, Marcel G M

    2015-02-01

    Process evaluation is a highly essential element for the increasing number of studies regarding multi-component interventions. Yet, researchers are challenged to collect and present appropriate process outcomes in such way that it is easy and valuable to be used by other researchers and policy makers in interpreting and comparing intervention effects because of the absence of standards for conducting and publishing process evaluation. This article describes the development of a method to concisely summarize the results of process evaluations of complex multi-component interventions. Development of a graph with the aim to facilitate the reporting of process evaluation's results, based on a narrative review of the literature for process measures used in complex interventions for elderly people. Seventeen articles of process evaluations alongside effect studies of complex interventions were reviewed. From these articles, it was found that process evaluations should address whether the intervention (1) was implemented successfully; (2) was evaluated properly; and (3) can be continued in the future. A flow chart based on the essential components of an adequate process evaluation was developed. A simplified but highly informative figure reporting a summary of the results of the process evaluation is proposed and its use is explained by administering the figure to two studies including a process and effect evaluation of a complex intervention. A graphical approach - which includes the core results of process evaluation and can be used directly in reporting effectiveness studies - will help researchers and policy makers to interpret and compare effects of complex multi-component interventions. © 2014 John Wiley & Sons, Ltd.

  1. Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network.

    Directory of Open Access Journals (Sweden)

    Loreta A Kondili

    Full Text Available Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure.To evaluate DAA failure incidence and the retreatment clinical impact in patients treated in the advanced liver disease stage.Data on HCV genotype, liver disease severity, and first and second line DAA regimens were prospectively collected in consecutive patients who reached the 12-week post-treatment and retreatment evaluations from January 2015 to December 2016 in 23 of the PITER network centers.Among 3,830 patients with advanced fibrosis (F3 or cirrhosis, 139 (3.6% failed to achieve SVR. Genotype 3, bilirubin levels >1.5mg/dl, platelet count <120,000/mm3 and the sofosbuvir+ribavirin regimen were independent predictors of failure by logistic regression analysis. The failure rate was 7.6% for patients treated with regimens that are no longer recommended or considered suboptimal (sofosbuvir+ribavirin or simeprevir+sofosbuvir±ribavirin, whereas 1.4% for regimens containing sofosbuvir combined with daclatasvir or ledipasvir or other DAAs. Of the patients who failed to achieve SVR, 72 (51.8% were retreated with a second DAA regimen, specifically 38 (52.7% with sofosbuvir+daclatasvir, 27 (37.5% with sofosbuvir+ledipasvir, and 7 (9.7% with other DAAs ±ribavirin. Among these, 69 (96% patients achieved SVR12 and 3 (4% failed. During a median time of 6 months (range: 5-14 months between failure and the second DAA therapy, the Child-Pugh class worsened in 12 (16.7% patients: from A to B in 10 patients (19.6% and from B to C in 2 patients (10.5%, whereas it did not change in the remaining 60 patients. Following the retreatment SVR12 (median time of 6 months; range: 3-12 months, the Child-Pugh class improved in 17 (23.6% patients: from B to A in 14 (19.4% patients, from C to A in 1 patient (1.4% and from C to B in 2 (2.9% patients; it remained unchanged in 53 patients (73.6% and worsened in 2 (2.8% patients. Of

  2. Design review report FFTF interim storage cask

    Energy Technology Data Exchange (ETDEWEB)

    Scott, P.L.

    1995-01-03

    Final Design Review Report for the FFTF Interim Storage Cask. The Interim Storage Cask (ISC) will be used for long term above ground dry storage of FFTF irradiated fuel in Core Component Containers (CCC)s. The CCC has been designed and will house assemblies that have been sodium washed in the IEM Cell. The Solid Waste Cask (SWC) will transfer a full CCC from the IEM Cell to the RSB Cask Loading Station where the ISC will be located to receive it. Once the loaded ISC has been sealed at the RSB Cask Loading Station, it will be transferred by facility crane to the DSWC Transporter. After the ISC has been transferred to the Interim Storage Area (ISA), which is yet to be designed, a mobile crane will be used to place the ISC in its final storage location.

  3. Results of evaluation of tailing dumps dust intensity

    Directory of Open Access Journals (Sweden)

    Masloboev V. A.

    2016-03-01

    Full Text Available A set of most acceptable and well-known methods of dust intensity evaluation has been defined and tested (dependence of Westphal D. L. et al. and DEAD scheme based on the analysis of exiting approaches (deserts, tailing dumps, etc.. The description of the chosen methods has been given. The determination of dynamic velocity u* and velocity at the height of +10 m above the dusting surface u10 which are necessary to evaluate the dust intensity has been demonstrated. The method is based on two-dimensional numerical model of atmosphere aerodynamics in the area of "tailing dumps of ANOF-2 ‒ the town of Apatity". The study provides calculations of horizontal velocity at the height of +10 m above the dusting surface at the wind speed varying from 5 to 23 m/sec. The work also suggests the results of graphical data processing related to tailing grain size distribution from the surface of the firmly established surface of the tailing dumps of ANOF-2. Comparative analysis has been given and the peculiarities of interval (based on grains sizes dust intensity of the tailing dumps of ANOF-2 have been shown using the dependence of Westphal D. L. et al. and DEAD scheme within the wind speed range. The received values of dust intensity at the lower range limit are close to the "maximum specific dust off" value which is used by project specialists for documentation development

  4. Role and Evaluation of Interlaboratory Comparison Results in Laboratory Accreditation

    Science.gov (United States)

    Bode, P.

    2008-08-01

    Participation in interlaboratory comparisons provides laboratories an opportunity for independent assessment of their analytical performance, both in absolute way and in comparison with those by other techniques. However, such comparisons are hindered by differences in the way laboratories participate, e.g. at best measurement capability or under routine conditions. Neutron activation analysis laboratories, determining total mass fractions, often see themselves classified as `outliers' since the majority of other participants employ techniques with incomplete digestion methods. These considerations are discussed in relation to the way results from interlaboratory comparisons are evaluated by accreditation bodies following the requirements of Clause 5.9.1 of the ISO/IEC 17025:2005. The discussion and conclusions come largely forth from experiences in the author's own laboratory.

  5. King County Metro Transit Hybrid Articulated Buses: Final Evaluation Results

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, K.; Walkowicz, K.

    2006-12-01

    Final technical report compares and evaluates new diesel and diesel hybrid-electric articulated buses operated as part of the King County Metro Transit (KC Metro) fleet in Seattle, Washington. The evaluation lasted 12 months.

  6. SEE - Sight Effectiveness Enhancement. Results of the automotive evaluation

    DEFF Research Database (Denmark)

    Andersen, V.; Hansen, K.D.; Cathala, T.

    2006-01-01

    In the SEE project two parallel evaluations have been conducted, an experimental trial of the automotive and another of the aeronautical application. The evaluations have measured the efficiency and HMI (human-machine interaction) characteristics of theSEE prototype. This report covers the automo......In the SEE project two parallel evaluations have been conducted, an experimental trial of the automotive and another of the aeronautical application. The evaluations have measured the efficiency and HMI (human-machine interaction) characteristics of theSEE prototype. This report covers...... the automotive part of the evaluation. The evaluation of the automotive application was carried out in computer simulated environments and followed the general objectives of the evaluation described in ‘Definition of theEvaluation Plan’ . The field experiment discussed, however, was given up due to lack...

  7. Evaluation of patch test results in patients with contact dermatitis

    Directory of Open Access Journals (Sweden)

    Yavuz Yeşilova

    2011-12-01

    Full Text Available Objectives: Patch test is the most reliable method to diagnose allergic contact dermatitis and to find out the responsible contact allergen. The aim of this retrospective study was to evaluate the patch test results of patients with contact dermatitis in our region.Materials and methods: One Hundred fifty patients (84 female and 66 male with contact dermatitis were patch tested with European standard test series. The testing has been standardized by the international Contact Dermatitis Research Group (ICDRG.Results: A majority of the lesions (36% were localized on the hands. In 31 female (58,4% and 21 male (4,6% patients (a total of 72 patients there were positive allergic reactions to at least one chemical. Nickel sulphate (13,3%, potassium dichromate (11,3% and cobalt chloride (8,6% were the most often allergens reacted.Conclusion: Nickel sensitivity is more common. Comparing with healthy controls contact sensitization may be more prevalent in patients with contact dermatitis.

  8. Evaluating the Impact of Database Heterogeneity on Observational Study Results

    Science.gov (United States)

    Madigan, David; Ryan, Patrick B.; Schuemie, Martijn; Stang, Paul E.; Overhage, J. Marc; Hartzema, Abraham G.; Suchard, Marc A.; DuMouchel, William; Berlin, Jesse A.

    2013-01-01

    Clinical studies that use observational databases to evaluate the effects of medical products have become commonplace. Such studies begin by selecting a particular database, a decision that published papers invariably report but do not discuss. Studies of the same issue in different databases, however, can and do generate different results, sometimes with strikingly different clinical implications. In this paper, we systematically study heterogeneity among databases, holding other study methods constant, by exploring relative risk estimates for 53 drug-outcome pairs and 2 widely used study designs (cohort studies and self-controlled case series) across 10 observational databases. When holding the study design constant, our analysis shows that estimated relative risks range from a statistically significant decreased risk to a statistically significant increased risk in 11 of 53 (21%) of drug-outcome pairs that use a cohort design and 19 of 53 (36%) of drug-outcome pairs that use a self-controlled case series design. This exceeds the proportion of pairs that were consistent across databases in both direction and statistical significance, which was 9 of 53 (17%) for cohort studies and 5 of 53 (9%) for self-controlled case series. Our findings show that clinical studies that use observational databases can be sensitive to the choice of database. More attention is needed to consider how the choice of data source may be affecting results. PMID:23648805

  9. Combined Modality Treatment for PET-Positive Non-Hodgkin Lymphoma: Favorable Outcomes of Combined Modality Treatment for Patients With Non-Hodgkin Lymphoma and Positive Interim or Postchemotherapy FDG-PET

    Energy Technology Data Exchange (ETDEWEB)

    Halasz, Lia M. [Harvard Radiation Oncology Program, Boston, Massachusetts (United States); Jacene, Heather A. [Department of Imaging, Dana-Farber Cancer Institute, and Department of Radiology, Brigham and Women' s Hospital, Boston, Massachusetts (United States); Catalano, Paul J. [Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Van den Abbeele, Annick D. [Department of Imaging, Dana-Farber Cancer Institute, and Department of Radiology, Brigham and Women' s Hospital, Boston, Massachusetts (United States); LaCasce, Ann [Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Mauch, Peter M. [Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women' s Hospital, Boston, Massachusetts (United States); Ng, Andrea K., E-mail: ang@lroc.harvard.edu [Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women' s Hospital, Boston, Massachusetts (United States)

    2012-08-01

    Purpose: To evaluate outcomes of patients treated for aggressive non-Hodgkin lymphoma (NHL) with combined modality therapy based on [{sup 18}F]fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET) response. Methods and Materials: We studied 59 patients with aggressive NHL, who received chemotherapy and radiation therapy (RT) from 2001 to 2008. Among them, 83% of patients had stage I/II disease. Patients with B-cell lymphoma received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)-based chemotherapy, and 1 patient with anaplastic lymphoma kinase-negative anaplastic T-cell lymphoma received CHOP therapy. Interim and postchemotherapy FDG-PET or FDG-PET/computed tomography (CT) scans were performed for restaging. All patients received consolidated involved-field RT. Median RT dose was 36 Gy (range, 28.8-50 Gy). Progression-free survival (PFS) and local control (LC) rates were calculated with and without a negative interim or postchemotherapy FDG-PET scan. Results: Median follow-up was 46.5 months. Thirty-nine patients had negative FDG-PET results by the end of chemotherapy, including 12 patients who had a negative interim FDG-PET scan and no postchemotherapy PET. Twenty patients were FDG-PET-positive, including 7 patients with positive interim FDG-PET and no postchemotherapy FDG-PET scans. The 3-year actuarial PFS rates for patients with negative versus positive FDG-PET scans were 97% and 90%, respectively. The 3-year actuarial LC rates for patients with negative versus positive FDG-PET scans were 100% and 90%, respectively. Conclusions: Patients who had a positive interim or postchemotherapy FDG-PET had a PFS rate of 90% at 3 years after combined modality treatment, suggesting that a large proportion of these patients can be cured with consolidated RT.

  10. [Penile protheses multicentre practice evaluation, results after 282 procedures].

    Science.gov (United States)

    Menard, Johann; Tremeaux, Jack-Charles; Faix, Antoine; Staerman, Frédéric

    2007-04-01

    Multicentre practice evaluation in the field of penile prostheses based on the Club des Implanteurs de Prosthèses Péniennes (CIPP) database. 282 penile prostheses, including 276 inflatable prostheses (97.8%), were implanted in 254 patients between 1996 and 2005 in three centres (1 public and 2 private). Preoperative data (patient's age, aetiology and duration of erectile dysfunction, preliminary treatments) and intraoperative data (type of implant used, surgical approach) were recorded. Postoperative complications were studied and postoperative erectile function was evaluated by a self-administered questionnaire (IIEF). The mean follow-up was 27.7 months. Penile prostheses were implanted after an average of 39.2 months of erectile dysfunction in patients with a mean age of 58.6 years. The main aetiologies were arterial disease (35.3%), diabetes (22.8%) and radical prostatectomy (16.5%). The postoperative sepsis rate was 2.2% and the mechanical dysfunction rate was 7.5% at the beginning of the operators' experience. The rate of other complications requiring repeat surgery (erosion, migration, self-inflation) was 1.8% at the beginning of the operators' experience. The septic risk was increased (7.6%) in the presence of diabetes (p = 0.01). The postoperative overall satisfaction was 86.7% and the IIEF score increased from 20.5 +/- 11.8 preoperatively to 68.9 +/- 5.4 postoperatively. Penile prostheses achieve a high postoperative satisfaction score with a low complication rate. However, they are only indicated after failure of less invasive treatments and must be implanted by experienced operators. These results are comparable to those of large international single-centre series.

  11. Thyroid dysfunction during pregnancy and evaluation of its results

    Directory of Open Access Journals (Sweden)

    Fatih Taşkesen

    2011-06-01

    Full Text Available In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women.Materials and methos: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH, free tri-iyodotironin (T3, free thyroxine (T4 levels for all patients were studied. Antithyroidal peroxidase (anti-TPO and Anti-thyroglobulin (anti-Tg parameters were measured if they were necessary. The relationship between thyroid functions and complications such as eclampsia, preeclampsia, maternal anemia, postpartum hemorrhage, fetal anomalies, shoulder dystocia, neonatal hypoglycemia was examined.Results: Hypothyroidism was found 18 of cases and hyperthyroidism was found 4 of them. The mean age of patients in the study was 26.42 (± 8.42. The mean values were 1.86 ± 0.19 μIU/mL for TSH, 1.15 ± 0.29 ng/mL for free T4 and 2.90 ± 0.31 pg/mL for free T3 respectively. Hashimoto’s thyroiditis (9 cases, 50 % was the most frequent etiology for patients with hypothyroidism. Other etiologic factors for hypothyroidism were found to be for 4 cases as (22.2%, iatrogenic (previously undergone thyroidectomy and 5 cases as (37.8% a lack of iodine. Maternal anemia was observed in 5 (27.78% cases with hypothyroidism. Preeclampsia was observed 16.67% in patients with hypothyroidism.Conclusion: Observed thyroid dysfunction in pregnant women may cause serious maternal and fetal complications. For disorders of thyroid function during pregnancy, to provide the necessary treatment at the appropriate time is important to prevent complications of mother and fetus. J Clin Exp Invest 2011;2(2:196-201

  12. 76 FR 74834 - Interim Staff Guidance on Aging Management Program for Steam Generators

    Science.gov (United States)

    2011-12-01

    ... COMMISSION Interim Staff Guidance on Aging Management Program for Steam Generators AGENCY: Nuclear Regulatory... Program for Steam Generators.'' This LR-ISG provides the NRC staff's evaluation of the suitability of using Revision 3 of the Nuclear Energy Institute's (NEI) document, NEI 97-06, ``Steam Generator Program...

  13. Engineering report single-shell tank farms interim measures to limit infiltration through the vadose zone

    Energy Technology Data Exchange (ETDEWEB)

    HAASS, C.C.

    1999-10-14

    Identifies, evaluates and recommends interim measures for reducing or eliminating water sources and preferential pathways within the vadose zone of the single-shell tank farms. Features studied: surface water infiltration and leaking water lines that provide recharge moisture, and wells that could provide pathways for contaminant migration. An extensive data base, maps, recommended mitigations, and rough order of magnitude costs are included.

  14. Cost Implications of an Interim Storage Facility in the Waste Management System

    Energy Technology Data Exchange (ETDEWEB)

    Jarrell, Joshua J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Joseph, III, Robert Anthony [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Howard, Rob L [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Petersen, Gordon M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nutt, Mark [Argonne National Lab. (ANL), Argonne, IL (United States); Carter, Joe [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Cotton, Thomas [Complex Systems Group, Bozeman, MT (United States)

    2016-09-01

    This report provides an evaluation of the cost implications of incorporating a consolidated interim storage facility (ISF) into the waste management system (WMS). Specifically, the impacts of the timing of opening an ISF relative to opening a repository were analyzed to understand the potential effects on total system costs.

  15. Global Spent Fuel Logistics Systems Study (GSFLS). Volume 2A. GSFLS visit findings (appendix). Interim report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-31

    This appendix is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. This appendix provides the legal/regulatory reference material, supportive of Volume 2 - GSFLS Visit Finding and Evaluations; and certain background material on British Nuclear Fuel Limited (BNFL).

  16. Interim Policy Options for Commercialization of Solar Heating and Cooling Systems.

    Science.gov (United States)

    Bezdek, Roger

    This interim report reviews the major incentive policy options available to accelerate market penetration of solar heating and cooling (SHAC) systems. Feasible policy options designed to overcome existing barriers to commercial acceptance and market penetration are identified and evaluated. The report is divided into seven sections, each dealing…

  17. Prediction and measurement of entrained flow coal gasification processes. Interim report, September 8, 1981-September 7, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Hedman, P.O.; Smoot, L.D.; Fletcher, T.H.; Smith, P.J.; Blackham, A.U.

    1984-01-31

    This volume reports interim experimental and theoretical results of the first two years of a three year study of entrained coal gasification with steam and oxygen. The gasifier facility and testing methods were revised and improved. The gasifier was also modified for high pressure operation. Six successful check-out tests at elevated pressure were performed (55, 75, 100, 130, 170, and 215 psig), and 8 successful mapping tests were performed with the Utah bituminous coal at an elevated pressure of 137.5 psig. Also, mapping tests were performed at atmospheric pressure with a Utah bituminous coal (9 tests) and with a Wyoming subbituminous coal (14 tests). The LDV system was used on the cold-flow facility to make additional nonreactive jets mixing measurements (local mean and turbulent velocity) that could be used to help validate the two-dimensional code. The previously completed two-dimensional entrained coal gasification code, PCGC-2, was evaluated through rigorous comparison with cold-flow, pulverized coal combustion, and entrained coal gasification data. Data from this laboratory were primarily used but data from other laboratories were used when available. A complete set of the data used has been compiled into a Data Book which is included as a supplemental volume of this interim report. A revised user's manual for the two-dimensional code has been prepared and is also included as a part of this interim report. Three technical papers based on the results of this study were published or prepared. 107 references, 57 figures, 35 tables.

  18. Ultrasonic Evaluation of Deeply Located Trabecular Bones - Preliminary Results

    Science.gov (United States)

    Cieślik, Lucyna; Litniewski, Jerzy

    The analysis of ultrasonic signals scattered by soft tissues have been successfully applied for their characterization. Similarly, the trabecular bone backscattered signal contains information about the properties of the bone structure. Therefore scattering-based ultrasonic technique potentially enables the assessment of microstructure characteristics of a bone. The femoral neck fracture often occurs in the course of osteoporosis and can lead to severe complications. Therefore assessment of femoral bone microstructure and condition is important and essential for the diagnosis and treatment monitoring. As far most of the trabecular bone investigations have been performed in vitro. The only in vivo measurements were carried out in transmission and mostly concerned estimation of the attenuation in heel bone. We have built the ultrasonic scanner that could be useful in acquiring the RF (Radio Frequency) echoes backscattered by the trabecular bone in vivo. Moreover, the bone scanner provides data not only from heel bone but from deeply located bones as well (e.g. femoral bone). It can be also used for easily accessible bones like heel bone or breastbone. In this case a gel-pad is applied to assure focusing of ultrasound in trabecular bone (approximately 10 mm beneath the cortical bone). This study presents preliminary results of the attenuating properties evaluation of trabecular bone from the ultrasonic echoes backscattered by heel bone and femoral neck.

  19. Evaluation of flat-Earth approximation results for geopotential missions.

    Science.gov (United States)

    Tapley, M. B.

    1997-04-01

    Simplified calculations can approximate the formal uncertainties in estimates of the spherical harmonic coefficients representing the Earth's gravitational potential. The calculations model the Earth locally as a plane, producing errors negligible for wavelengths shorter than the radius of the Earth. Information derived from observations of low altitude polar orbiting satellites is considered. With some constraints, the final model uncertainties derive from a priori gravitational field information, specific orbital elements, and parameters describing instrumentation characteristics. The author demonstrates how to refine the technique to accept inputs from the currently operational Navstar Global Positioning System (GPS) constellation and how to use information from partial tensor gravitational gradiometers. This approach is beneficial when evaluating prospective satellite geodesy missions because the covariance analyses for various mission scenarios can be made efficiently and expeditiously. The author demonstrates the utility of the flat Earth approach by comparing results with those of more elaborate and time consuming calculations performed for the European Space Agency ARISTOTELES proposed geopotential mapping mission, the NASA Gravity Probe B Relativity mission, and the NASA/Center National d'Etudes Spatiales Topographic Ocean Experiment Satellite (TOPEX)/Poseidon mission.

  20. BC Transit Fuel Cell Bus Project: Evaluation Results Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-02-01

    This report evaluates a fuel cell electric bus demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. This evaluation report covers two years of revenue service data on the buses from April 2011 through March 2013.

  1. Benchmarking Evaluation Results for Prototype Extravehicular Activity Gloves

    Science.gov (United States)

    Aitchison, Lindsay; McFarland, Shane

    2012-01-01

    subjects representing the design ]to hand anthropometry completed range of motion, grip/pinch strength, dexterity, and fit evaluations for each glove design in both the unpressurized and pressurized conditions. This paper provides a comparison of the test results along with a detailed description of hardware and test methodologies used.

  2. Van interim-management naar tijdelijk leiderschap

    NARCIS (Netherlands)

    Schaveling, J.

    2008-01-01

    Het fenomeen interim-management, maar ook het tijdelijk inzetten van interne mensen op managementposities, neemt de laatste tijd een hoge vlucht. Welke voorwaarden zijn nodig om dit tot een succes te laten worden? En wat is de stand van zaken ervan in de praktijk?

  3. Interim Report - Grant AFOSR-85-0065.

    Science.gov (United States)

    1985-06-30

    Option 065 Drafting Plotter 1 7475A 6 Pen Graphics Plotter Vendor: Imagen Corporation $ 11,266 1 Model 8/300 Laser Printer System, 512Kbytes memory 1... Imagen 8/300 Laser Printer 3 Interim Report Grant No. AFOSR-85-0065 was equivalent to the Versatec plotter for small plots and better for text output

  4. LANDFILL BIOREACTOR PERFORMANCE, SECOND INTERIM REPORT

    Science.gov (United States)

    A bioreactor landfill is a landfill that is operated in a manner that is expected to increase the rate and extent of waste decomposition, gas generation, and settlement compared to a traditional landfill. This Second Interim Report was prepared to provide an interpretation of fie...

  5. A Non-Traditional Interim Project.

    Science.gov (United States)

    Brown, Diane; Ward, Dorothy

    1980-01-01

    Describes a project initiated by the Foreign Language Department of Birmingham-Southern College for their Interim term and discusses an interdisciplinary course focusing on Medieval Europe. The course included presentations on German and French language and literature, as well as lectures on the arts, philosophy, and family life of the period.…

  6. Difficulties in evaluating abnormal lead screening results in children.

    Science.gov (United States)

    Block, B; Szekely, K; Escobar, M

    1996-01-01

    This report chronicles efforts to provide follow-up care for children with abnormal whole blood lead concentrations using the 1991 Centers for Disease Control and Prevention (CDC) guidelines in the Family Health Center at Shadyside Hospital in Pittsburgh. An automated surveillance module found all children with abnormal lead concentrations obtained between January 1994 and July 1995 and singled out children who were overdue for follow-up. Automated physician reminders and nursing case management were used to improve care and documentation. Longitudinal case summaries were used to evaluate care. All 99 children with a lead concentration of 10 micrograms/dL or greater had a documented follow-up plan. Twenty-nine children (47 percent) who had a lead concentration of 10 to 14 micrograms/dL, 23 (100 percent) who had a lead concentration of 15 to 19 micrograms/dL, and 8 (100 percent) who had a lead concentration of 20 micrograms/dL or greater had at least one follow-up lead concentration measurement by the end of the data collection in July 1995. Follow-up was incomplete in more than 70 percent of children. Nineteen children (19 percent) with initially abnormal lead concentrations had follow-up testing with persistently normal results. The yearly cost of follow-up was $15,888, with only 7 children requiring county health environmental intervention. The nurse-centered, computer-aided system improved follow-up care of children with abnormal lead concentrations, but most patients still did not receive mandated follow-up testing because of logistic obstacles. The effort and cost associated with CDC-mandated follow-up of children with lead concentrations between 10 and 19 micrograms/dL provides no apparent benefit and might detract from the care of children at higher risk.

  7. Using ERA-Interim reanalysis for creating datasets of energy-relevant climate variables

    Science.gov (United States)

    Jones, Philip D.; Harpham, Colin; Troccoli, Alberto; Gschwind, Benoit; Ranchin, Thierry; Wald, Lucien; Goodess, Clare M.; Dorling, Stephen

    2017-07-01

    The construction of a bias-adjusted dataset of climate variables at the near surface using ERA-Interim reanalysis is presented. A number of different, variable-dependent, bias-adjustment approaches have been proposed. Here we modify the parameters of different distributions (depending on the variable), adjusting ERA-Interim based on gridded station or direct station observations. The variables are air temperature, dewpoint temperature, precipitation (daily only), solar radiation, wind speed, and relative humidity. These are available on either 3 or 6 h timescales over the period 1979-2016. The resulting bias-adjusted dataset is available through the Climate Data Store (CDS) of the Copernicus Climate Change Data Store (C3S) and can be accessed at present from ftp://ecem.climate.copernicus.eu. The benefit of performing bias adjustment is demonstrated by comparing initial and bias-adjusted ERA-Interim data against gridded observational fields.

  8. Evaluation Results From Prospective Drug Utilization Review: Medicaid Demonstrations

    OpenAIRE

    Kidder, David; Bae, Jay

    1999-01-01

    In 1992 HCFA awarded two cooperative agreements for demonstrations of prospective drug utilization review (PDUR). Iowa tested an on-line prospective drug utilization review (OPDUR) system. Washington tested payments to pharmacists for providing non-dispensing “cognitive services” (CS). In this article the authors report on an evaluation of these demonstrations and on three assessments of retrospective drug utilization review (RDUR) interventions. The evaluation failed to detect effects of eit...

  9. An Interim Report on NASA's Draft Space Technology Roadmaps

    Science.gov (United States)

    2011-01-01

    NASA has developed a set of 14 draft roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist (OCT). Each of these roadmaps focuses on a particular technology area (TA). The roadmaps are intended to foster the development of advanced technologies and concepts that address NASA's needs and contribute to other aerospace and national needs. OCT requested that the National Research Council conduct a study to review the draft roadmaps, gather and assess relevant community input, and make recommendations and suggest priorities to inform NASA's decisions as it finalizes its roadmaps. The statement of task states that "based on the results of the community input and its own deliberations, the steering committee will prepare a brief interim report that addresses high-level issues associated with the roadmaps, such as the advisability of modifying the number or technical focus of the draft NASA roadmaps." This interim report, which does not include formal recommendations, addresses that one element of the study charge. NASA requested this interim report so that it would have the opportunity to make an early start in modifying the draft roadmaps based on feedback from the panels and steering committee. The final report will address all other tasks in the statement of task. In particular, the final report will include a prioritization of technologies, will describe in detail the prioritization process and criteria, and will include specific recommendations on a variety of topics, including many of the topics mentioned in this interim report. In developing both this interim report and the final report to come, the steering committee draws on the work of six study panels organized by technical area, loosely following the organization of the 14 roadmaps, as follows: A Panel 1: Propulsion and Power TA01 Launch Propulsion Systems TA02 In-Space Propulsion Technologies TA03 Space Power and Energy Storage Systems TA13

  10. Early rehabilitation of facial defects using interim removable prostheses: A clinical case report

    Directory of Open Access Journals (Sweden)

    Vivekanandhan Ramkumar

    2013-01-01

    Full Text Available Surgical resection of neoplasms or malformations of the face may result in defects that are not amenable to immediate surgical reconstruction. Such defects can have a severe adverse effect on patient perceptions of body image and self-esteem. In these cases, the use of an interim removable facial prosthesis can offer a rapid alternative treatment solution. The patient may then resume social interactions more comfortably while permitting easy access to the facial defect to observe tissue healing while awaiting definitive rehabilitation. This article presents a case report describing the use of interim nasal prostheses to provide rapid patient rehabilitation of facial defects.

  11. BC Transit Fuel Cell Bus Project Evaluation Results: Second Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Post, M.

    2014-09-01

    Second report evaluating a fuel cell electric bus (FCEB) demonstration led by British Columbia Transit (BC Transit) in Whistler, Canada. BC Transit is collaborating with the California Air Resources Board and the U.S. Department of Energy's National Renewable Energy Laboratory to evaluate the buses in revenue service. NREL published its first report on the demonstration in February 2014. This report is an update to the previous report; it covers 3 full years of revenue service data on the buses from April 2011 through March 2014 and focuses on the final experiences and lessons learned.

  12. Results of evaluation of tailing dumps dust intensity

    OpenAIRE

    Masloboev V. A.; Baklanov A. A.; Amosov P. V.

    2016-01-01

    A set of most acceptable and well-known methods of dust intensity evaluation has been defined and tested (dependence of Westphal D. L. et al. and DEAD scheme) based on the analysis of exiting approaches (deserts, tailing dumps, etc.). The description of the chosen methods has been given. The determination of dynamic velocity u* and velocity at the height of +10 m above the dusting surface u10 which are necessary to evaluate the dust intensity has been demonstrated. The method is based on two-...

  13. Thyroid dysfunction during pregnancy and evaluation of its results

    OpenAIRE

    Bostancı, Mehmet Sühha; Taşkesen, Fatih

    2011-01-01

    S Objectives: In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women. Materials and methods: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH), free tri-iyodotironin (T3), free thyroxine (T4) levels for all patients were stud...

  14. Thyroid dysfunction during pregnancy and evaluation of its results

    OpenAIRE

    Fatih Taşkesen; Mehmet Sühha Bostancı

    2011-01-01

    In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women.Materials and methos: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH), free tri-iyodotironin (T3), free thyroxine (T4) levels for all patients were studied. Antithyroidal per...

  15. Validation of HOAPS- and ERA-Interim precipitation estimates over the ocean

    Science.gov (United States)

    Bumke, Karl; Schröder, Marc; Fennig, Karsten

    2014-05-01

    hit rate have been computed. Summarized, the results show that HOAPS data agrees well with observations with respect to the frequency of precipitation events while ERA-Interim overestimates considerably the number of precipitation events. Results are similar for rain and snow events. Although it is difficult to compare rain rates directly due to the limited number of collocated events and different spatial resolution, the results suggest a slight underestimation of precipitation rates by HOAPS and an overestimation by ERA-Interim. References Andersson, A., Klepp, C., Fennig, K., Bakan, S., Graßl, H. and495 co-authors. 2011. Evaluation of HOAPS-3 ocean surface freshwater flux components. J. Appl. Meteorol. Climatol. 50, 379-398, doi:10.1175/2010JAMC2341.1. Levizzani, V., Bauer, P. and Turk, F. J.) 2007. Measuring Precipitation from Space, EURAINSAT and the Future. Advances in Global Change Research, Vol. 28, Springer, 724 p. Pfeifroth,U.,R.Mueller, and B.Ahrens, 2012: Evaluation of Satellite-Based and Reanalysis Precipitation Data in the Tropical Pacific, J. of Appl. Meteorology and Climatology 52, 634-644

  16. 10 CFR 709.15 - Processing counterintelligence evaluation results.

    Science.gov (United States)

    2010-01-01

    ... financial, credit, travel, and other relevant information to resolve any identified issues. Participation by Office of Intelligence and Counterintelligence personnel in any such evaluation is subject to Executive Order 12333, the DOE “Procedures for Intelligence Activities,” and other relevant laws, guidelines, and...

  17. The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short-term inhalation exposure: interim results.

    Science.gov (United States)

    Bernstein, D M; Rogers, R A; Sepulveda, R; Donaldson, K; Schuler, D; Gaering, S; Kunzendorf, P; Chevalier, J; Holm, S E

    2010-09-01

    The pathological response and translocation of a commercial chrysotile product similar to that which was used through the mid-1970s in a joint compound intended for sealing the interface between adjacent wall boards was evaluated in comparison to amosite asbestos. This study was unique in that it presents a combined real-world exposure and was the first study to investigate whether there were differences between chrysotile and amosite asbestos fibers in time course, size distribution, and pathological response in the pleural cavity. Rats were exposed by inhalation 6 h/day for 5 days to either sanded joint compound consisting of both chrysotile fibers and sanded joint compound particles (CSP) or amosite asbestos. Subgroups were examined through 1-year postexposure. No pathological response was observed at any time point in the CSP-exposure group. The long chrysotile fibers (L > 20 microm) cleared rapidly (T(1/2) of 4.5 days) and were not observed in the pleural cavity. In contrast, a rapid inflammatory response occurred in the lung following exposure to amosite resulting in Wagner grade 4 interstitial fibrosis within 28 days. Long amosite fibers had a T(1/2) > 1000 days and were observed in the pleural cavity within 7 days postexposure. By 90 days the long amosite fibers were associated with a marked inflammatory response on the parietal pleural. This study provides support that CSP following inhalation would not initiate an inflammatory response in the lung, and that the chrysotile fibers present do not migrate to, or cause an inflammatory response in the pleural cavity, the site of mesothelioma formation.

  18. Evaluation results of using sole Ilizarov fixator in Pilon fractures

    Directory of Open Access Journals (Sweden)

    Ahmad Reza Mirbolook

    2014-02-01

    Conclusion: According to the results obtained and comparing them with the results of other treatments ,one can claim that this treating approach is better than the others for pilon fractures,particularly for type 3c pilon fractures.

  19. Psychological Evaluation Results in Patients Confronted with Sexual Abuse

    OpenAIRE

    Işık Karakaya; Ayşen Coşkun; Belma Ağaoğlu; Şahika Gülen Şişmanlar; Özlem Yıldız Öç; Nursu Çakın Memik; Ümit Biçer

    2006-01-01

    Child and adolescent sexual abuse have lifelong consequences. Sexual development, emotional effects, depressed mood, anxiety, behavioral effects and alteration of personality are some possible consequences of sexual abuse. In this article we evaluated psychiatric symptoms according to DSM-IV diagnostic criteria in 21 sexually abused children and adolescents. Twelve girls and nine boys between 4 and 16 years of age were investigated. All the patients belonged to low socioeconomic strata. The m...

  20. Evaluating participatory research: Framework, methods and implementation results.

    Science.gov (United States)

    Smajgl, Alex; Ward, John

    2015-07-01

    This paper describes a structured participatory process and associated evaluation protocol developed to detect systems learning by decision makers involved in the management of natural resources. A series of facilitated participatory workshops were conducted to investigate learning when decision makers and influencers were confronted with the multiple, complex interactions arising from decisions concerned with the nexus of water, food and energy security. The participatory process and evaluation of learning were trialled in the Greater Mekong Subregion (GMS), where integrated scientific evidence was systematically presented to challenge existing beliefs concerned with the effectiveness of proposed policy actions and development investments. Consistent with theoretical propositions, individually held values, beliefs and attitudes were deployed as the primary factors (and psychometrics) that underpin and influence environmental management decision making. Observed and statistically significant changes in the three psychometrics expressed by decision makers in response to the facilitated presentation of scientific evidence during the participatory process, provided supportive evidence of systems learning and the evaluation protocol. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  1. Learning results and evaluation through levels given by the results in Religious Education

    Directory of Open Access Journals (Sweden)

    Emil Lazar

    2016-05-01

    Full Text Available Multilevel approach to religious education assessment entails rethinking the evaluative approach, starting from the systemic perspective on the evaluation object to religion, like regulatory reporting, to curriculum and who materialized from inductive perspective, in terms of subject assessment, the entire complexity of the student. The Assessment Tool that we proposed is an integrative one, an opportunity to see the process, be aware of the process by which it is evaluated and develop the ability to track what is happening in this process and intervene for the evaluator. It is about a formative assessment, as long as the proposed instrument "crosses the boundaries of various learning activities". As a school discipline, Religion is integrative one (contributing, complementing the student's general education and integrator (harmonizing the various skills of the student's academic in progress tracked throughout the student's education unit. Religious education provides and contributes to personal development of students and (self empowering their formation process, exceeding the borders of a single discipline and ensuring premises skills training trans-disciplinary on the basis of specific skills, necessary for personal development of the student. Finally, this idea of approaching religion as a subject from the perspective of education for values is very interesting and debated.

  2. Interim data monitoring to enroll higher-risk participants in HIV prevention trials

    Directory of Open Access Journals (Sweden)

    Umo-Otong John

    2009-06-01

    Full Text Available Abstract Background Lower-than-expected incidence of HIV undermines sample size calculations and compromises the power of a HIV prevention trial. We evaluated the effectiveness of interim monitoring of HIV infection rates and on-going modification of recruitment strategies to enroll women at higher risk of HIV in the Cellulose Sulfate Phase III study in Nigeria. Methods We analyzed prevalence and incidence of HIV and other sexually transmitted infections, demographic and sexual behavior characteristics aggregated over the treatment groups on a quarterly basis. The site investigators were advised on their recruitment strategies based on the findings of the interim analyses. Results A total of 3619 women were screened and 1644 enrolled at the Ikeja and Apapa clinics in Lagos, and at the Central and Peripheral clinics in Port Harcourt. Twelve months after study initiation, the overall incidence of HIV was less than one-third of the pre-study assumption, with rates of HIV that varied substantially between clinics. Due to the low prevalence and incidence rates of HIV, it was decided to close the Ikeja clinic in Lagos and to find new catchment areas in Port Harcourt. This strategy was associated with an almost two-fold increase in observed HIV incidence during the second year of the study. Conclusion Given the difficulties in estimating HIV incidence, a close monitoring of HIV prevalence and incidence rates during a trial is warranted. The on-going modification of recruitment strategies based on the regular analysis of HIV rates appeared to be an efficient method for targeting populations at greatest risk of HIV infection and increasing study power in the Nigeria trial. Trial Registration The trial was registered with the ClinicalTrials.gov registry under #NCT00120770 http://clinicaltrials.gov/ct2/show/NCT00120770

  3. Radium-223-Dichloride in Castration Resistant Metastatic Prostate Cancer—Preliminary Results of the Response Evaluation Using F-18-Fluoride PET/CT

    Directory of Open Access Journals (Sweden)

    Kalevi Kairemo

    2015-10-01

    Full Text Available The purpose of this study was to evaluate the outcome after Radium-223-dichloride (223RaCl2 treatment of patients with skeletal metastases of castration resistant prostate cancer using whole-body 18F-Fluoride PET/CT. Sodium 18F-fluoride [18F]-NaF PET/CT was performed prior the treatment of 223RaCl2, after the first cycle and after the sixth cycle. The skeletal metastases were analyzed quantitatively using modified PET response evaluation PERCIST criteria. The patients were also analyzed for S-PSA. All ten patients responded in [18F]-NaF scans after 6 cycles, but interim analysis after the 1st cycle did not give additional information about the outcome. The S-PSA decrease correlated with [18F]-NaF response, only 1 patient demonstrated progressive disease, i.e., >25% increase in S-PSA values during 223RaCl2. Our results (although preliminary suggest that 18F-Fluoride PET/CT is useful in the follow-up of castration resistant prostate cancer with skeletal metastases.

  4. Psychological Evaluation Results in Patients Confronted with Sexual Abuse

    Directory of Open Access Journals (Sweden)

    Işık Karakaya

    2006-08-01

    Full Text Available Child and adolescent sexual abuse have lifelong consequences. Sexual development, emotional effects, depressed mood, anxiety, behavioral effects and alteration of personality are some possible consequences of sexual abuse. In this article we evaluated psychiatric symptoms according to DSM-IV diagnostic criteria in 21 sexually abused children and adolescents. Twelve girls and nine boys between 4 and 16 years of age were investigated. All the patients belonged to low socioeconomic strata. The most frequently diagnosed psychiatric disorders in these children were posttraumatic stress disorder, separation anxiety disorder, major depressive disorder and elimination disorder. Sexually abused children and adolescents present various psychiatric symptoms. So, understanding the consequences of sexual abuse on children and adolescents is significant in assessment, prevention, and treatment. Key words: Child, adolescent, sexual abuse, psychiatric effects

  5. MICROBIOLOGICAL EVALUATION OF WATER BUFFALO COLOSTRUM: FIRST RESULTS

    Directory of Open Access Journals (Sweden)

    P. Catellani

    2012-08-01

    Full Text Available Animal colostrum contains many substances with antibacterial activity such as lysozyme and lactoferrin which should inhibit the microbial growth. The aim of this research is to understand if colostrum can be considered a safe product, considering that Regulation (EC N° 1662/2006, which has modified the Regulation (EC N° 853/2004, introducing colostrum as human food. Microbiological tests, made on water buffalo colostrum, aiming to obtain the total microbial count (maximum concentration: 3,6•104 ufc/ml, the quantitative evaluation of total (maximum the highest concentration found: 2,3•103 ufc/ml and fecal coliforms (maximum concentration: 4,9•102 ufc/ml and the qualitative search of Salmonella spp. and Listeria monocytogenes, showed that there is not a microbial growth in colostrum, that it can be considered a safe food, from the microbial point of view

  6. [LAPTOP trial--results of an health economics evaluation].

    Science.gov (United States)

    Dippel, F-W

    2008-08-01

    Based on the LAPTOP trial, a cost and a benefit assessment were undertaken. The cost analysis was performed as a desk-top evaluation using the cost minimization method. The benefit assessment was done as a simulation using the diabetes mellitus model (DMM). In each analysis either cost or benefit of treating diabetes mellitus with oral antidiabetic drug(s) supported by insulin glargine were compared to those with conventional insulin treatment using premixed insulin twice daily. The cost benefit analysis demonstrated that treatment with insulin glargine plus oral antidiabetics was less expensive than the conventional insulin treatment with premixed insulin. Furthermore, avoidance of diabetic complications was better with insulin glargine plus oral antidiabetics than with premixed insulin alone.

  7. Soil compaction: Evaluation of stress transmission and resulting soil structure

    DEFF Research Database (Denmark)

    Naveed, Muhammad; Schjønning, Per; Keller, Thomas

    Accurate estimation of stress transmission and resultant deformation in soil profiles is a prerequisite for the development of predictive models and decision support tools for preventing soil compaction. Numerous studies have been carried out on the effects of soil compaction, whilst relatively few...... and compaction-resulted soil structure at the same time. Stress transmission was quantified using both X-ray CT and Tactilus sensor mat, and soil-pore structure was quantified using X-ray CT. Our results imply that stress transmission through soil highly depends on the magnitude of applied load and aggregate...... studies have focused on the cause (mode of stress transmission in the soil). We have coupled both cause and effects together in the present study by carrying out partially confined compression tests on (1) wet aggregates, (2) air dry aggregates, and (3) intact soils to quantify stress transmission...

  8. Individual shareholders’ understanding of the content of interim reports of South African listed retail companies

    Directory of Open Access Journals (Sweden)

    Johan GI Oberholster

    2015-05-01

    Full Text Available A number of studies conducted, and reports published, by international and local accounting bodies have found that the proliferation of disclosures in financial reports has hampered users’ understanding of these reports. The reports by accounting bodies also indicate that these users prefer more concise financial reports. These findings, in conjunction with a dearth of recent questionnaire-based research on whether individual shareholders understand the content of financial reports, resulted in this study on whether individual shareholders understand the content of interim reports. The study provides empirical proof that a sound knowledge of business, accounting and economic matters is a prerequisite for understanding interim reports in the case of individual shareholders. The results of the study indicate that individual shareholders have a limited understanding of the content of interim reports as a whole, and that a good knowledge of business and economic matters and of accounting results in an improved understanding of the content of interim reports. In particular, specialisation in accounting in undergraduate and postgraduate degrees, professional qualifications, and work experience in the financial field improve the understanding of individual shareholders.

  9. Evaluation of antiretroviral therapy results in Blantyre, Malawi | van ...

    African Journals Online (AJOL)

    The most common side effect was peripheral neuropathy. Nevirapine plasma levels were remarkably high and associated with successful virological treatment results. Two simple adherence questions pertaining to the use of medication in the previous 8 days corresponded well with nevirapine levels. The most important ...

  10. Soil compaction: Evaluation of stress transmission and resulting soil structure

    Science.gov (United States)

    Naveed, Muhammad; Schjønning, Per; Keller, Thomas; Lamande, Mathieu

    2016-04-01

    Accurate estimation of stress transmission and resultant deformation in soil profiles is a prerequisite for the development of predictive models and decision support tools for preventing soil compaction. Numerous studies have been carried out on the effects of soil compaction, whilst relatively few studies have focused on the cause (mode of stress transmission in the soil). We have coupled both cause and effects together in the present study by carrying out partially confined compression tests on (1) wet aggregates, (2) air dry aggregates, and (3) intact soils to quantify stress transmission and compaction-resulted soil structure at the same time. Stress transmission was quantified using both X-ray CT and Tactilus sensor mat, and soil-pore structure was quantified using X-ray CT. Our results imply that stress transmission through soil highly depends on the magnitude of applied load and aggregate strength. As soon as the applied load is lower than the aggregate strength, the mode of stress transmission is discrete as stresses were mainly transmitted through chain of aggregates. With increasing applied load soil aggregates start deforming that transformed heterogeneous soil into homogenous, as a result stress transmission mode was shifted from discrete towards more like a continuum. Continuum-like stress transmission mode was better simulated with Boussinesq (1885) model based on theory of elasticity compared to discrete. The soil-pore structure was greatly affected by increasing applied stresses. Total porosity was reduced 5-16% and macroporosity 50-85% at 620 kPa applied stress for the intact soils. Similarly, significant changes in the morphological indices of the macropore space were also observed with increasing applied stresses.

  11. [Hearing screening at nursery schools: results of an evaluation study].

    Science.gov (United States)

    Weichbold, Viktor; Rohrer, Monika; Winkler, Cornelia; Welzl-Müller, Kunigunde

    2004-07-31

    This study aimed to evaluate the hearing screening of pre-school children at nursery schools in Tyrol, Austria. 47 nursery schools with a total of 2199 enrolled children participated in the study. At the screening, the children were presented a series of tones at frequencies 0.5 kHz (25dB), 1 kHz, 2 kHz, 3 kHz, and 4 kHz (20 dB each) from portable audiometers. The tones were presented over headphones for each ear separately and at irregular intervals. Failure to respond to any of the frequencies was considered failure of the screening. Parents were then advised in written form to have the child examined by an ENT-specialist. 1832 individuals were screened (coverage: 83% of nursery school children; corresponding to at least 63% of all Tyrolean children aged 3 to 5 years). Of these, 390 failed the test (referral rate: 21% of all screened). Examination through an ENT-specialist occurred with 217 children, and this confirmed the positive test in 139 children (hit rate: 64%). In most cases, a temporary conductive hearing loss due to external or middle ear problems (glue ear, tube dysfunction, cerumen, otitis media) was diagnosed. A sensorineural hearing loss was found in 4 children (in 3 of them bilateral). The need for therapy was recognized in 81 children (4% of all screened). Pre-school hearing screening identifies children with ear and hearing problems that need therapeutical intervention. Although the hearing problems are mostly of a temporary nature, some may require monitoring over some period. Also some children with permanent sensorineural hearing loss may be detected through this measure. Hearing screening is an efficient means of assessing ear and hearing problems in pre-school children. However, the follow-up rate needs to be improved for optimizing the efficacy.

  12. Evaluating EU Regional Policy: Many Empirical Specifications, One (Unpleasant) Result

    DEFF Research Database (Denmark)

    Breidenbach, Philipp; Mitze, Timo; Schmidt, Christoph

    Numerous studies have focused on the role of EU regional policy in fostering growth and convergence among European regions, why conducting another one? We argue that two facts are still lacking in the actual academic debate in order to get a sound empirical identification strategy and reliable...... results: First, one should take the theoretical underpinnings of regional growth models more serious, and second, a likewise careful account of the role of spatial dependence in the underlying data is needed. Though research has increasingly become aware of the latter point as important control factor...

  13. SULFURIC ACID REMOVAL PROCESS EVALUATION: SHORT-TERM RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Gary M. Blythe; Richard McMillan

    2002-03-04

    results of the short-term tests; the long-term test results will be reported in a later document. The short-term test results showed that three of the four reagents tested, dolomite powder, commercial magnesium hydroxide slurry, and byproduct magnesium hydroxide slurry, were able to achieve 90% or greater removal of sulfuric acid compared to baseline levels. The molar ratio of alkali to flue gas sulfuric acid content (under baseline conditions) required to achieve 90% sulfuric acid removal was lowest for the byproduct magnesium hydroxide slurry. However, this result may be confounded because this was the only one of the three slurries tested with injection near the top of the furnace across from the pendant superheater platens. Injection at the higher level was demonstrated to be advantageous for this reagent over injection lower in the furnace, where the other slurries were tested.

  14. SULFURIC ACID REMOVAL PROCESS EVALUATION: SHORT-TERM RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Gary M. Blythe; Richard McMillan

    2002-02-04

    the results of the short-term tests; the long-term test results will be reported in a later document. The short-term test results showed that three of the four reagents tested, dolomite powder, commercial magnesium hydroxide slurry, and byproduct magnesium hydroxide slurry, were able to achieve 90% or greater removal of sulfuric acid compared to baseline levels. The molar ratio of alkali to flue gas sulfuric acid content (under baseline conditions) required to achieve 90% sulfuric acid removal was lowest for the byproduct magnesium hydroxide slurry. However, this result may be confounded because this was the only one of the three slurries tested with injection near the top of the furnace across from the pendant superheater platens. Injection at the higher level was demonstrated to be advantageous for this reagent over injection lower in the furnace, where the other slurries were tested.

  15. Preliminary results on scintigraphic evaluation of malignant external otitis

    Energy Technology Data Exchange (ETDEWEB)

    Malamitsi, J.; Maragoudakis, P. (Hippocrateion Hospital, Athens (Greece). Dept. of Nuclear Medicine); Papafragou, K.; Koukouliou, V. (Athens Univ. (Greece). Dept. of Medical Physics); Kalatzis, Y.; Adamopoulos, G.; Proukakis, C. (Hippocrateion Hospital, Athens (Greece). ORL Univ. Clinic)

    1993-06-01

    Malignant external otitis (MEO) is a potentially fatal otitis occurring in diabetic and immunosuppressed patients, which may cause cranial nerve palsies and massive thrombophlebitis of the brain. We studied five diabetic patients with the clinical diagnosis of external otitis who were suspected of having MEO and one diabetic patient presumed cured from MEO. All of them underwent methylene diphosphonate, nanocolloid and gallium single-photon emission tomography studies with quantitative analysis on the basis of regions of interest and count profile curves. This combined assessment helped us to diagnose and follow-up soft tissue and temporal bone infection, especially in the case of transsphenoidal extension of the disease, since conventional radiology and computed tomography were of no particular help. On the basis of these results, we consider scintigraphic demonstration of skull base infection as a fourth criterion of MEO given that the classical Chandler's triad (diabetes, granuloma, and Pseudomonas aeruginosa) is not always present. (orig.).

  16. Veterans Employment Pay for Success Grant Program. Interim final rule.

    Science.gov (United States)

    2016-08-10

    The Department of Veterans Affairs (VA) is establishing a grant program (Veterans Employment Pay for Success (VEPFS)) under the authority of the U.S.C. to award grants to eligible entities to fund projects that are successful in accomplishing employment rehabilitation for Veterans with service-connected disabilities. VA will award grants on the basis of an eligible entity's proposed use of a Pay for Success (PFS) strategy to achieve goals. This interim final rule establishes regulations for awarding a VEPFS grant, including the general process for awarding the grant, criteria and parameters for evaluating grant applications, priorities related to the award of a grant, and general requirements and guidance for administering a VEPFS grant program.

  17. SNF Interim Storage Canister Corrosion and Surface Environment Investigations

    Energy Technology Data Exchange (ETDEWEB)

    Bryan, Charles R. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Enos, David G. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    This progress report describes work being done at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of spent nuclear fuel (SNF). Of particular concern is stress corrosion cracking (SCC), by which a through-wall crack could potentially form in a canister outer wall over time intervals that are shorter than possible dry storage times. In order for SCC to occur, three criteria must be met. A corrosive environment must be present on the canister surface, the metal must susceptible to SCC, and sufficient tensile stress to support SCC must be present through the entire thickness of the canister wall. SNL is currently evaluating the potential for each of these criteria to be met.

  18. Evaluating Surface Flux Results from CERES-FLASHFlux

    Science.gov (United States)

    Wilber, A. C.; Stackhouse, P. W., Jr.; Kratz, D. P.; Gupta, S. K.; Sawaengphokhai, P.

    2016-12-01

    The Clouds and Earth's Radiant Energy System (CERES) mission provides TOA (Top-of-Atmosphere) and surface radiative flux products for each CERES footprint (Single Scanner Footprint) and also time integrated and spatially averaged (TISA) to provide 1ox1o fluxes at various temporal averages. The CERES TISA products are available to the public within 3-6 months of observation. The CERES Fast Longwave and SHortwave radiative Flux (FLASHFlux) data products were developed to provide a rapid release version of the CERES data products. FLASHFlux data products are made available to the research and applications communities within one week of the satellite observations. Over the last several years, the CERES team has contributed to a section on the variability of radiation budget at the Top-of-Atmosphere in the annual "State of the Climate Report" published in BAMS using CERES TISA and FLASHFlux data products. Recently, the FLASHFlux data were used to investigate the radiative impacts of the intense 2015-2016 El Nino event. In addition FLASHFlux date are routinely used by applied science in energy related and agricultural sectors. The current version of FLASHFlux is being upgraded to FLASHFlux Version4A to improve consistency with the climate quality Edition 4 CERES data products. This presentation will describe the planned changes including the change to the latest meteorological product from Global Modeling and Assimilation Office (GMAO), GEOS FP-IT (5.12.4). GEOS 5.12.4 is an assimilation that is consistent with MERRA-2. We present comparisons of global and regional changes in the TOA and surface radiative fluxes as a result of the upgrade for both longwave (LW) and shortwave (SW) surface fluxes. We also compare the data products against ground measurements using data from the Baseline Surface Radiation Network (BSRN) - including NOAA SURFRAD, Atmospheric Radiation Measurement (ARM) and Ocean buoy measurements from Woods Hole Oceanographic Institute (WHOI).

  19. Evaluation of Thompson's quadricepsplasty results in patients with knee stiffness resulted from femoral fracture

    Directory of Open Access Journals (Sweden)

    Hamid Mousavi

    2017-01-01

    Full Text Available Background: Posttraumatic and/or postsurgical knee stiffness is one of the orthopedic complications which is difficult to be treated and can affect individual's life negatively. The aim of this study is to investigate the results of quadricepsplasty in patients with knee stiffness resulted from femoral fracture. Materials and Methods: This is a cross-sectional study on all patients with femoral fracture which has caused knee flexion limitation referred to Kashani and Al-Zahra Hospitals in Isfahan from January 2010 to March 2013. The type and site of fracture, joint extension, and fracture fixation technique were recorded. Moreover, the range of motion (ROM before surgery, under general anesthesia, and 3- and 6-month postoperation were measured. Results: Among the patients, 13 had a simple fracture (48% and 14 had a segmental fracture (51.9%. Considering the fracture site, 11, 10, and 6 patients had femoral (40.74%, supracondylar (37.3%, and femoral supracondylar (22.2% fractures, respectively. The fracture fixation was performed by the plate, external, and Wagner fixation techniques for 24 (88.9%, 2 (7.4%, and 1 (3.7% patients, respectively. The mean ROM before operation, under general anesthesia, and 3- and 6-month postoperation were determined to be 33.15° ± 24.73°, 122.60° ± 10.22°, 99.63° ± 16.52°, and 100.74° ± 15.67°, respectively. The mean ROM value at various stages was not similar (P < 0.001. The mean changes in the ROM were 79.2° ± 24.6° and 62.1° ± 19.7° in the cases with simple and segmental fractures, respectively. The mean changes in the knee ROM were significantly higher in simple fractures in comparison with the segmental femoral fracture (P = 0.03. Conclusion: We found Thompson's quadricepsplasty may successfully increase the range of knee flexion in knee fracture and also regardless of quadriceps time.

  20. Thermal-Mechanical Stress Analysis of PWR Pressure Vessel and Nozzles under Grid Load-Following Mode: Interim Report on the Effect of Cyclic Hardening Material Properties and Pre-existing Cracks on Stress Analysis Results

    Energy Technology Data Exchange (ETDEWEB)

    Mohanty, Subhasish [Argonne National Lab. (ANL), Argonne, IL (United States); Soppet, William [Argonne National Lab. (ANL), Argonne, IL (United States); Majumdar, Saurin [Argonne National Lab. (ANL), Argonne, IL (United States); Natesan, Ken [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-03-15

    This report provides an update on an assessment of environmentally assisted fatigue for light water reactor components under extended service conditions. This report is a deliverable under the work package for environmentally assisted fatigue as part of DOE’s Light Water Reactor Sustainability Program. In a previous report (September 2015), we presented tensile and fatigue test data and related hardening material properties for 508 low-alloys steel base metal and other reactor metals. In this report, we present thermal-mechanical stress analysis of the reactor pressure vessel and its hot-leg and cold-leg nozzles based on estimated material properties. We also present results from thermal and thermal-mechanical stress analysis under reactor heat-up, cool-down, and grid load-following conditions. Analysis results are given with and without the presence of preexisting cracks in the reactor nozzles (axial or circumferential crack). In addition, results from validation stress analysis based on tensile and fatigue experiments are reported.

  1. Interim Report - Baseline Population Inventory of Amphibians on the Mountain Longleaf National Wildlife Refuge and Screening for the Amphibian Disease Batrachochytrium dendrobatidis

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Interim report provides the initial results of baseline amphibian survey and surveillance for chytrid disease on the mountain Longleaf National wildlife Refuge.

  2. 47 CFR 51.715 - Interim transport and termination pricing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Interim transport and termination pricing. 51.715 Section 51.715 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... Telecommunications Traffic § 51.715 Interim transport and termination pricing. (a) Upon request from a...

  3. 50 CFR 660.720 - Interim protection for sea turtles.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Interim protection for sea turtles. 660... Migratory Fisheries § 660.720 Interim protection for sea turtles. (a) Until the effective date of §§ 660.707... harvest of swordfish (Xiphias gladius) using longline gear deployed on the high seas of the Pacific Ocean...

  4. General certification procedure of enterprises and interim job enterprises

    CERN Document Server

    Int. At. Energy Agency, Wien

    2002-01-01

    This procedure defines the certification global process of enterprises employing workers of A or B category for nuclear facilities and interim job enterprises proposing workers of A or B category for nuclear facilities. This certification proves the enterprises ability to satisfy the specification ''E'' of the CEFRI and the interim job enterprises to satisfy the specification ''I'' of the CEFRI. (A.L.B.)

  5. 40 CFR 80.141 - Interim detergent gasoline program.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Interim detergent gasoline program. 80... (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Detergent Gasoline § 80.141 Interim detergent gasoline... apply to: (i) All gasoline sold or transferred to a party who sells or transfers gasoline to the...

  6. 46 CFR 308.203 - Amount insured under interim binder.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Amount insured under interim binder. 308.203 Section 308.203 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.203 Amount insured under interim binder. The...

  7. 46 CFR 308.303 - Amounts insured under interim binder.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Amounts insured under interim binder. 308.303 Section... INSURANCE Second Seamen's War Risk Insurance § 308.303 Amounts insured under interim binder. The amounts... of the date of a casualty involving the subject vessel. Upon the attachment of this binder, the...

  8. 46 CFR 308.103 - Insured amounts under interim binder.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Insured amounts under interim binder. 308.103 Section 308.103 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Hull and Disbursements Insurance § 308.103 Insured amounts under interim binder. (a...

  9. National NIF Diagnostic Program Interim Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Warner, B

    2002-04-25

    The National Ignition Facility (NIF) has the mission of supporting Stockpile Stewardship and Basic Science research in high-energy-density plasmas. To execute those missions, the facility must provide diagnostic instrumentation capable of observing and resolving in time events and radiation emissions characteristic of the plasmas of interest. The diagnostic instrumentation must conform to high standards of operability and reliability within the NIF environment. These exacting standards, together with the facility mission of supporting a diverse user base, has led to the need for a central organization charged with delivering diagnostic capability to the NIF. The National NIF Diagnostics Program (NNDP) has been set up under the aegis of the NIF Director to provide that organization authority and accountability to the wide user community for NIF. The funds necessary to perform the work of developing diagnostics for NIF will be allocated from the National NIF Diagnostics Program to the participating laboratories and organizations. The participating laboratories and organizations will design, build, and commission the diagnostics for NIF. Restricted availability of funding has had an adverse impact, unforeseen at the time of the original decision to projectize NIF Core Diagnostics Systems and Cryogenic Target Handing Systems, on the planning and initiation of these efforts. The purpose of this document is to provide an interim project management plan describing the organizational structure and management processes currently in place for NIF Core Diagnostics Systems. Preparation of a Program Execution Plan for NIF Core Diagnostics Systems has been initiated and a current draft is provided as Attachment 1 to this document. The National NIF Diagnostics Program Interim Management Plan provides a summary of primary design criteria and functional requirements, current organizational structure, tracking and reporting procedures, and current planning estimates of project scope

  10. 50 CFR 259.30 - Application for Interim Capital Construction Fund Agreement (“Interim CCF Agreement”).

    Science.gov (United States)

    2010-10-01

    ...) Date of construction, acquisition, or reconstruction, (vii) Fishery of operation (which in this section... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Application for Interim Capital Construction Fund Agreement (âInterim CCF Agreementâ). 259.30 Section 259.30 Wildlife and Fisheries NATIONAL...

  11. Evaluating Teachers More Strategically: Using Performance Results to Streamline Evaluation Systems. Issue Brief

    Science.gov (United States)

    White, Taylor

    2014-01-01

    Teacher evaluation systems introduced by states and school systems in the past several years have focused attention on improving the performance of public school teachers, but they have been cost- and time-intensive, placing a significant burden on states' and districts' resources. In Tennessee, for example, trained evaluators conducted nearly…

  12. The challenges facing the long term interim storage

    Energy Technology Data Exchange (ETDEWEB)

    Iracane, D. [CEA Sacaly, Dir. de la Simulation et des Outils Experimentaux-DSOE, 91 - Gif sur Yvette (France); Marvy, A. [CEA Saclay, Dir. du Developpement et de l' Innovation Nucleares-DDIN, 91 - Gif Sur Yvette (France)

    2001-07-01

    In France electricity generation by means of commercial nuclear power plants has come to a point where it contributes to the national demand at a level of 80%. The safety performance of the production system has also reached a high level of both maturity and reliability taking advantage of the cumulative effect of a 30 years long learning experience and ever more stringent safety requirements. The policy to reprocess spent fuel has been overriding but no final decision has yet been made regarding the ultimate disposition of the waste streams. Although studies on deep geological disposal are ongoing, France is also looking at whether and under which conditions a long-term interim storage may provide an effective flexibility to the fuel cycle back-end. We discuss thereafter the needs and the paramount objectives of this latter R and D program. Results are being framed as potential guiding criteria for decision makers and various stakeholders. In first part, we propose a general analysis which emphasises that a long term interim storage is more than a classical nuclear facility because it explicitly requires long-lasting control and creates a burden for Society during many generations. Then, in second part, we offer an overview of the technical results from the R and D program as they stand at the time of writing. As an answer to the Government request, a strong emphasis has been put on this research for three years. Conclusion is an attempt to outline the societal context in which future decisions will have to be made. (author)

  13. Flexural strength and hardness of resins for interim fixed partial dentures

    Directory of Open Access Journals (Sweden)

    Liju Jacob Jo

    2011-01-01

    Full Text Available Context: Materials used for the fabrication of interim restorations must satisfy biological, esthetic, and functional needs. Strength and wear resistance are two important physical properties contributing to clinical efficiency. Aim: The objective of this in vitro study was to evaluate and compare the flexural strength and hardness of five resins used for the fabrication of interim fixed partial dentures. Materials and Methods: Five groups containing ten specimens of each material were fabricated in customized brass split molds with dimensions 65×10×2.5 mm. The materials subjected to this study were Revotek LC™ (group RLC, Protemp II™ (group PSC, Acry-lux V™ with regular monomer (group AHC, Acry-lux V™ with self-cure monomer (group ASC, DPI™ self-cure tooth molding powder (group DSC. The specimens were polymerized according to the manufacturers′ instructions and were evaluated for flexural strength using a universal testing machine and for hardness using a microhardness tester. Statistical Analysis: The mean of the five groups was compared using one way analysis of variance (ANOVA and pair-wise comparison was done using Tukeys honesty significance difference (HSD test. P≤.05 was considered to be statistically significant. Results: Flexural test results showed that group AHC (79.8950 MPa had the highest flexural strength followed, in descending order, by group PSC (77.9700 MPa, group ASC (63.7150 MPa, group RLC (58.8110 MPa, and group DSC (51.9840 MPa. Statistically, the difference was found to be highly significant among all the groups. The hardness tests showed that group AHC (17.6900 KHN had the highest hardness value followed, in descending order, by group PSC (15.9400 KHN, group RLC (12.6000 KHN, group ASC (11.2500 KHN, and group DSC (8.7700 KHN. Statistically, the difference was found to be highly significant among all the groups. Conclusion: Group AHC, representing a heat-polymerizing resin, showed the highest flexural

  14. PROJECT W-551 INTERIM PRETREATMENT SYSTEM PRECONCEPTUAL CANDIDATE TECHNOLOGY DESCRIPTIONS

    Energy Technology Data Exchange (ETDEWEB)

    MAY TH

    2008-08-12

    The Office of River Protection (ORP) has authorized a study to recommend and select options for interim pretreatment of tank waste and support Waste Treatment Plant (WTP) low activity waste (LAW) operations prior to startup of all the WTP facilities. The Interim Pretreatment System (IPS) is to be a moderately sized system which separates entrained solids and 137Cs from tank waste for an interim time period while WTP high level waste vitrification and pretreatment facilities are completed. This study's objective is to prepare pre-conceptual technology descriptions that expand the technical detail for selected solid and cesium separation technologies. This revision includes information on additional feed tanks.

  15. Test results evaluation: Pilot evaluations Deliverable no D6.5. Final draft

    NARCIS (Netherlands)

    Hoedemaeker, D.M.; Dangelmaier, M.; Gelau, C.; Mattes, S.; Montanari, R.

    2003-01-01

    This deliverable describes the User Centred Design approach that has been adopted within the COMUNICAR project. In this design approach several iterative steps were taken to design and evaluate the multimedia Human Machine Interface that is able to manage all the information exchanges between the

  16. Evaluation of an Experimental Intensive French Programme for Grade Eight Students.

    Science.gov (United States)

    Morrison, Frances Crook

    This interim report on an experimental program to increase student motivation to learn French at the Cultural Centre of Intensive French (CCIF) examines objectives, evaluation procedures, and results of the experiment. Part 1 contains sections on: (1) French achievement in Ottawa, Canada, grade 8 classes, (2) Pimsleur listening comprehension test,…

  17. Natural tooth as an interim prosthesis.

    Science.gov (United States)

    Dhariwal, Neha S; Gokhale, Niraj S; Patel, Punit; Hugar, Shivayogi M

    2016-01-01

    A traumatic injury to primary maxillary anterior tooth is one of the common causes for problems with the succedaneous tooth leading to it noneruption. A missing anterior tooth can be psychologically and socially damaging to the patient. Despite a wide range of treatment options available, sometimes, it is inevitable to save the natural tooth. This paper describes the immediate replacement of a right central incisor using a fiber-composite resin splint with the natural tooth crown as a pontic following surgical extraction of the dilacerated impacted permanent maxillary central incisor. The abutment teeth can be conserved with minimal or no preparation, thus keeping the technique reversible and can be completed at chair side thereby avoiding laboratory costs. It can be used as an interim measure until a definitive prosthesis can be fabricated as the growth is still incomplete.

  18. Results

    African Journals Online (AJOL)

    child.” (CIN, breastfeeding mother). “I am terribly stressed when I consider that the baby will be crying a lot and become difficult and this may force me to continue breastfeeding.” (FGD, breastfeeding mother). Women cited intense psychological stress when children were ill. This influenced them to re-evaluate their decision.

  19. Solid rocket technology advancement for Space Tug and IUS applications. [Interim Upper Stage

    Science.gov (United States)

    Ascher, W.; Bailey, R. L.; Behm, J. W.; Gin, W.

    1975-01-01

    Two-burn restartable solid propellant rocket motors for the kick stage (auxiliary stage) of the Shuttle Tug, or Interim Upper Stage, are described, with details on features and test results of the ignition and quench (thrust termination) systems and procedures, fabrication of propellant and insulation, explosion hazards of propellants, and comparative data on present and future motor design. These rocket motor systems are designed for upper stage augmentation of launch vehicles and possible service in Shuttle-launched outer planet spacecraft.

  20. Interim Feed The Future Population Based Assessment of Cambodia

    Data.gov (United States)

    US Agency for International Development — This is the interim population based survey of Feed the Future in Cambodia for 2015. The data is split into survey modules. Modules A through C includes location...

  1. 13 CFR 120.890 - Source of interim financing.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Source of interim financing. 120.890 Section 120.890 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS... or professional construction manager.) ...

  2. TANK FARM INTERIM SURFACE BARRIER MATERIALS AND RUNOFF ALTERNATIVES STUDY

    Energy Technology Data Exchange (ETDEWEB)

    HOLM MJ

    2009-06-25

    This report identifies candidate materials and concepts for interim surface barriers in the single-shell tank farms. An analysis of these materials for application to the TY tank farm is also provided.

  3. Big Oaks National Wildlife Refuge : Interim Public Access Plan : 2000

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This interim plan covers public access for Big Oaks National Wildlife Refuge. Sections include introduction, safety briefing protocols, entry procedure, types of...

  4. Interim research assessment 2003-2005 - Computer Science

    NARCIS (Netherlands)

    Mouthaan, A.J.; Hartel, Pieter H.

    This report primarily serves as a source of information for the 2007 Interim Research Assessment Committee for Computer Science at the three technical universities in the Netherlands. The report also provides information for others interested in our research activities.

  5. Students' interim literacies as a dynamic resource for teaching and ...

    African Journals Online (AJOL)

    . ... This article explores the notion of 'interim literacies'by drawing on data from a research project which used linguistic and intertextual analysis of first year student writing in economics to investigate the intersection of academic discourse and ...

  6. Intelligent cruise control field operational test : interim report

    Science.gov (United States)

    1997-03-01

    This interim document reports on a cooperative agreement between NHTSA and UMTRI entitled Intelligent Cruise Control (ICC) Field Operational Test (FOT). The overarching goal of the work is to characterize safety and comfort issues that are fundamenta...

  7. Interim Safety Basis for Fuel Supply Shutdown Facility

    Energy Technology Data Exchange (ETDEWEB)

    BENECKE, M.W.

    2000-09-07

    This ISB, in conjunction with the IOSR, provides the required basis for interim operation or restrictions on interim operations and administrative controls for the facility until a SAR is prepared in accordance with the new requirements or the facility is shut down. It is concluded that the risks associated with tha current and anticipated mode of the facility, uranium disposition, clean up, and transition activities required for permanent closure, are within risk guidelines.

  8. K basins interim remedial action health and safety plan

    Energy Technology Data Exchange (ETDEWEB)

    DAY, P.T.

    1999-09-14

    The K Basins Interim Remedial Action Health and Safety Plan addresses the requirements of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), as they apply to the CERCLA work that will take place at the K East and K West Basins. The provisions of this plan become effective on the date the US Environmental Protection Agency issues the Record of Decision for the K Basins Interim Remedial Action, currently planned in late August 1999.

  9. Interim land use planning for the Rocky Flat Sites a phased approach

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, J.; Marquez, W. [S.M. Stoller Corp., Boulder, CO (United States)

    1994-12-31

    A phased approach to interim land use planning for the Rocky Flats site should be based on the elimination of land disposition constraints, as land disposition in the central land use planning issue to be decided for the site now that its mission has changed. Land use planning for Rocky Flats must be considered interim until a formal land use decision is made by DOE and the stakeholders. The most significant land disposition constraints for Rocky Flats are waste, Special Nuclear Material (SNM), and contamination. Waste is a significant potential constraint as a result of limited waste treatment and storage capacity onsite, as well as the site`s current unavailability for waste disposal. SNM onsite imposes safeguards and security restrictions that represent significant potential constraints to land disposition. Contamination is a potentially significant constraint depending on the cleanup level selected for an area.

  10. Immobilized low-activity waste interim storage facility, Project W-465 conceptual design report

    Energy Technology Data Exchange (ETDEWEB)

    Pickett, W.W.

    1997-12-30

    This report outlines the design and Total Estimated Cost to modify the four unused grout vaults for the remote handling and interim storage of immobilized low-activity waste (ILAW). The grout vault facilities in the 200 East Area of the Hanford Site were constructed in the 1980s to support Tank Waste disposal activities. The facilities were to serve project B-714 which was intended to store grouted low-activity waste. The existing 4 unused grout vaults, with modifications for remote handling capability, will provide sufficient capacity for approximately three years of immobilized low activity waste (ILAW) production from the Tank Waste Remediation System-Privatization Vendors (TWRS-PV). These retrofit modifications to the grout vaults will result in an ILAW interim storage facility (Project W465) that will comply with applicable DOE directives, and state and federal regulations.

  11. Probabilistic Assessment Method of Turbojet Engine Impact on an Interim Dry Storage Facility

    Energy Technology Data Exchange (ETDEWEB)

    Almomania, Belal; Kang, Hyun Gook [KAIST, Daejeon (Korea, Republic of); Lee, Sang Hoon [Keimyung University, Daegu (Korea, Republic of)

    2016-05-15

    This paper describes an analytical method of structural analysis for an interim storage facility subjected to aircraft jet engine based on a probabilistic approach. This method will be employed in the process of aircraft risk model for the interim storage facilities. The analytical formulation of the engine impact and the perforation to find the required thickness of concrete to protect the equipment inside the structure is an enormously complex impact phenomenon. Therefore, all the available formulas describing perforation phenomena are empirical and based on experimental data. In this paper, a method with sample results to determine the local failure probability of the facility's wall and the probable residual velocities after passed through the target by applying a probabilistic approach was proposed. Normal engine impact on the wall shield using applicable empirical formulas provides a best estimation of perforation depth and residual velocity with intent of producing conservative outcomes.

  12. Improving Ventilation and Saving Energy: Relocatable ClassroomField Study Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Apte, Michael G.; Buchanan, Ian S.; Faulkner, David; Hotchi,Toshifumi; Spears,Michael; Sullivan, Douglas P.; Wang, Duo

    2005-09-01

    The primary goals of this research effort are to develop, evaluate, and demonstrate a very practical HVAC system for classrooms that consistently provides classrooms with the quantity of ventilation in current minimum standards, while saving energy, and reducing HVAC-related noise levels. This research is motivated by the public benefits of energy efficiency, evidence that many classrooms are under-ventilated, and public concerns about indoor environmental quality in classrooms. This report presents an interim status update and preliminary findings from energy and indoor environmental quality (IEQ) measurements in sixteen relocatable classrooms in California. The field study includes measurements of HVAC energy use, ventilation rates, and IEQ conditions. Ten of the classrooms were equipped with a new HVAC technology and six control classrooms were equipped with a standard HVAC system. Energy use and many IEQ parameters have been monitored continuously, while unoccupied acoustic measurements were measured in one of four planned seasonal measurement campaigns. Continuously monitored data are remotely accessed via a LonWorks{reg_sign} network and stored in a relational database at LBNL. Preliminary results are presented here.

  13. Performance testing of aged hydrogen getters against criteria for interim safe storage of plutonium bearing materials.

    Energy Technology Data Exchange (ETDEWEB)

    Shepodd, Timothy J.; Nissen, April; Buffleben, George M.

    2006-01-01

    Hydrogen getters were tested for use in storage of plutonium-bearing materials in accordance with DOE's Criteria for Interim Safe Storage of Plutonium Bearing Materials. The hydrogen getter HITOP was aged for 3 months at 70 C and tested under both recombination and hydrogenation conditions at 20 and 70 C; partially saturated and irradiated aged getter samples were also tested. The recombination reaction was found to be very fast and well above the required rate of 45 std. cc H2h. The gettering reaction, which is planned as the backup reaction in this deployment, is slower and may not meet the requirements alone. Pressure drop measurements and {sup 1}H NMR analyses support these conclusions. Although the experimental conditions do not exactly replicate the deployment conditions, the results of our conservative experiments are clear: the aged getter shows sufficient reactivity to maintain hydrogen concentrations below the flammability limit, between the minimum and maximum deployment temperatures, for three months. The flammability risk is further reduced by the removal of oxygen through the recombination reaction. Neither radiation exposure nor thermal aging sufficiently degrades the getter to be a concern. Future testing to evaluate performance for longer aging periods is in progress.

  14. Evaluation of English Results Course Books at Upper-Intermediate Level

    Science.gov (United States)

    Haghi, Eshrat Bazarmaj

    2013-01-01

    The importance of the course books in language teaching leads the way to the evaluation of them. Evaluating the teaching materials specially course books can help teachers to understand more about language learning. The purpose of the present study is to evaluate English Results course books which are widely used at Iranian institutes. The focus…

  15. Challenging medical students with an interim assessment: a positive effect on formal examination score in a randomized controlled study.

    NARCIS (Netherlands)

    Olde Bekkink, M.; Donders, R.; Muijen, G.N.P. van; Ruiter, D.J.

    2012-01-01

    Until now, positive effects of assessment at a medical curriculum level have not been demonstrated. This study was performed to determine whether an interim assessment, taken during a small group work session of an ongoing biomedical course, results in students' increased performance at the formal

  16. Operable Unit 3: Proposed Plan/Environmental Assessment for interim remedial action

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    This document presents a Proposed Plan and an Environmental Assessment for an interim remedial action to be undertaken by the US Department of Energy (DOE) within Operable Unit 3 (OU3) at the Fernald Environmental Management Project (FEMP). This proposed plan provides site background information, describes the remedial alternatives being considered, presents a comparative evaluation of the alternatives and a rationnale for the identification of DOE`s preferred alternative, evaluates the potential environmental and public health effects associated with the alternatives, and outlines the public`s role in helping DOE and the EPA to make the final decision on a remedy.

  17. Interim measure work plan/design for Agra, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2008-11-18

    This Interim Measure Work Plan/Design (IMWP/D) is supplemental to the Argonne document Interim Measure Conceptual Design for Remediation of Source Area Contamination at Agra, Kansas. The IMWP/D includes information required by Kansas Department of Health and Environment (KDHE) Policy BER-RS-029, Policy and Scope of Work for Interim Measures. Specific to Policy BER-RS-029 is the requirement for several documents that will ensure that an adequate amount and type of data are collected for implementation of the IMWP/D and that data quality and safe conditions are prevailed. Such information is included in the IMWP/D as follows: Appendix A: Data Acquisition Plan--Design Testing Requirements; Appendix B: Basis of Design; Appendix C: Permits; Appendix D: Quality Assurance Project Plan; Appendix E: Health and Safety Plan; and Appendix F: Operations, Maintenance, and Monitoring Schedule. The proposed remedial technology for this project is the installation of five large-diameter boreholes (LDBs) in a source area that has been identified on the property formerly used for grain storage by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA). The goal of the LDB technology is the remediation of the source area by removal of mass quantities of contaminated soil from the vadose zone and treatment of any remaining contaminated soils that are adjacent to the source area to achieve a carbon tetrachloride concentration below 200 {micro}g/kg. Secondary to the soil remediation is the remediation of groundwater at and adjacent to the source areas. The LDB technology serves the following purposes: (1) The physical removal of contaminated soil from the identified source area. (2) Replacement of less permeable native materials (silty clay, clayey silt, and silty sand) with more permeable materials to facilitate the capture of volatilized contaminants in the vertical borehole. (3) Removal of contaminants volatilized by air sparging (AS) and extracted from the

  18. Failsafe automation of Phase II clinical trial interim monitoring for stopping rules.

    Science.gov (United States)

    Day, Roger S

    2010-02-01

    In Phase II clinical trials in cancer, preventing the treatment of patients on a study when current data demonstrate that the treatment is insufficiently active or too toxic has obvious benefits, both in protecting patients and in reducing sponsor costs. Considerable efforts have gone into experimental designs for Phase II clinical trials with flexible sample size, usually implemented by early stopping rules. The intended benefits will not ensue, however, if the design is not followed. Despite the best intentions, failures can occur for many reasons. The main goal is to develop an automated system for interim monitoring, as a backup system supplementing the protocol team, to ensure that patients are protected. A secondary goal is to stimulate timely recording of patient assessments. We developed key concepts and performance needs, then designed, implemented, and deployed a software solution embedded in the clinical trials database system. The system has been in place since October 2007. One clinical trial tripped the automated monitor, resulting in e-mails that initiated statistician/investigator review in timely fashion. Several essential contributing activities still require human intervention, institutional policy decisions, and institutional commitment of resources. We believe that implementing the concepts presented here will provide greater assurance that interim monitoring plans are followed and that patients are protected from inadequate response or excessive toxicity. This approach may also facilitate wider acceptance and quicker implementation of new interim monitoring algorithms.

  19. Database and Interim Glass Property Models for Hanford HLW Glasses

    Energy Technology Data Exchange (ETDEWEB)

    Hrma, Pavel R.; Piepel, Gregory F.; Vienna, John D.; Cooley, Scott K.; Kim, Dong-Sang; Russell, Renee L.

    2001-07-24

    The purpose of this report is to provide a methodology for an increase in the efficiency and a decrease in the cost of vitrifying high-level waste (HLW) by optimizing HLW glass formulation. This methodology consists in collecting and generating a database of glass properties that determine HLW glass processability and acceptability and relating these properties to glass composition. The report explains how the property-composition models are developed, fitted to data, used for glass formulation optimization, and continuously updated in response to changes in HLW composition estimates and changes in glass processing technology. Further, the report reviews the glass property-composition literature data and presents their preliminary critical evaluation and screening. Finally the report provides interim property-composition models for melt viscosity, for liquidus temperature (with spinel and zircon primary crystalline phases), and for the product consistency test normalized releases of B, Na, and Li. Models were fitted to a subset of the screened database deemed most relevant for the current HLW composition region.

  20. Interim performance criteria for photovoltaic energy systems. [Glossary included

    Energy Technology Data Exchange (ETDEWEB)

    DeBlasio, R.; Forman, S.; Hogan, S.; Nuss, G.; Post, H.; Ross, R.; Schafft, H.

    1980-12-01

    This document is a response to the Photovoltaic Research, Development, and Demonstration Act of 1978 (P.L. 95-590) which required the generation of performance criteria for photovoltaic energy systems. Since the document is evolutionary and will be updated, the term interim is used. More than 50 experts in the photovoltaic field have contributed in the writing and review of the 179 performance criteria listed in this document. The performance criteria address characteristics of present-day photovoltaic systems that are of interest to manufacturers, government agencies, purchasers, and all others interested in various aspects of photovoltaic system performance and safety. The performance criteria apply to the system as a whole and to its possible subsystems: array, power conditioning, monitor and control, storage, cabling, and power distribution. They are further categorized according to the following performance attributes: electrical, thermal, mechanical/structural, safety, durability/reliability, installation/operation/maintenance, and building/site. Each criterion contains a statement of expected performance (nonprescriptive), a method of evaluation, and a commentary with further information or justification. Over 50 references for background information are also given. A glossary with definitions relevant to photovoltaic systems and a section on test methods are presented in the appendices. Twenty test methods are included to measure performance characteristics of the subsystem elements. These test methods and other parts of the document will be expanded or revised as future experience and needs dictate.

  1. Implementation and adoption of nationwide electronic health records in secondary care in England: final qualitative results from prospective national evaluation in “early adopter” hospitals

    Science.gov (United States)

    Cornford, Tony; Barber, Nicholas; Avery, Anthony; Takian, Amirhossein; Lichtner, Valentina; Petrakaki, Dimitra; Crowe, Sarah; Marsden, Kate; Robertson, Ann; Morrison, Zoe; Klecun, Ela; Prescott, Robin; Quinn, Casey; Jani, Yogini; Ficociello, Maryam; Voutsina, Katerina; Paton, James; Fernando, Bernard; Jacklin, Ann; Cresswell, Kathrin

    2011-01-01

    providers. There was early evidence that deploying systems resulted in important learning within and between organisations and the development of relevant competencies within NHS hospitals. Conclusions Implementation of the NHS Care Records Service in “early adopter” sites proved time consuming and challenging, with as yet limited discernible benefits for clinicians and no clear advantages for patients. Although our results might not be directly transferable to later adopting sites because the functionalities we evaluated were new and untried in the English context, they shed light on the processes involved in implementing major new systems. The move to increased local decision making that we advocated based on our interim analysis has been pursued and welcomed by the NHS, but it is important that policymakers do not lose sight of the overall goal of an integrated interoperable solution. PMID:22006942

  2. Electrodril System Field Test Program, interim phase. Final report, January--April 1977

    Energy Technology Data Exchange (ETDEWEB)

    1978-02-01

    The Interim Phase between Phase 1 Testing and the Phase 2 Major Drilling System Test included more detailed analyses, some redesign, and additional field testing required to rectify three problems that surfaced during Phase 1 Testing: motor lower seal failures, excessive wear of bit shaft seal, and cable/connector failures. The Phase 1 Motor Lower Seal Failures were found to have been caused by failure to rigidly fix the Face Seal Stator and by having the Face Seal inversely designed into the motor system. Downhole testing with the seal inversely installed but with the stator rigidly fixed demonstrated that the seal performed satisfactorily. In all subsequent use of the motor, the seal should be configured as recommended by the manufacturer. Interim Phase Downhole Testing demonstrated that a properly refurbished bit shaft is capable of functioning satisfactorily in a drilling environment. Seal wear experienced during test indicates that these seals should be replaced periodically. The Interim Phase was used to provide extensive analysis into Phase 1 Cable/Connector Failures, evaluation of potential cable conductor insulation material, evaluation of stronger, more rigid material for fabricating the male connector body, and evaluation of ''Bondability'' of materials used in connector fabrication and cable insulation. These analyses and evaluations were used as inputs in the design, fabrication, and procurement cycle to yield a new replaceable Electrodril connector pair and armored cable with water blocked MS type connectors capable of accepting the replaceable Electrodril connectors. Repeated downhole matings were made during test. The cable and the replaceable male connector performed flawlessly. The internal conductor rings in the replaceable female connector gradually became oversize as the test progressed. Subsequent female connector rings will be fabricated using a harder, springier material to assure successful downhole mating even after

  3. International Programs and Agreements in Geothermal Energy. An Interim report

    Energy Technology Data Exchange (ETDEWEB)

    Oppenheimer, M.; Fein, E.; Bye, J.

    1978-06-01

    This report contains the interim results of a study for the Division of Geothermal Energy on the Division's international programs and activities. The complete research program, which is scheduled to be finished i November 1978, will have the following elements: (1) an assessment of objectives that have motivated the formulation of international programs and an explanation of any changes in the evolution of those programs. These objectives will be assessed for their internal consistency, degree of governmental consensus, their practicality, the current status of their accomplishments, and the implications of their accomplishments for the role of DGE. (2) An assessment of organizational structures and teams, including the identity of key decisionmakers, the nature of the interagency process, procedures for generating nongovernmental support for international programs and the success of these procedures, and the effectiveness of the interface with foreign partners. (3) Assessment of results of international cooperative programs, which involve the development of an overall balance sheet of benefits and disbenefits attributed to each international program. (4) The formulation of future international cooperative programs based on the assessments described. These programs may involve the development of new exchanges, alteration or elimination of existing exchanges, and revisions in the management of exchanges by US government agencies.

  4. A digital technique for fabricating implant-supported interim restorations in the esthetic zone.

    Science.gov (United States)

    Liu, Xiaoqiang; Tan, Yao; Liu, Jianzhang; Tan, Jianguo

    2017-07-11

    A digital technique for fabricating an implant-supported interim restoration is presented. The labial cervical architecture of the natural tooth is captured before extraction and registered to form the emergence profile of the interim restoration. A well-contoured interim restoration is fabricated before surgery and connected to the immediately placed implant with a customized interim abutment. Copyright © 2017 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  5. PRELIMINARY RESULTS: EVALUATIONS OF THE ALTERNATIVE ASBESTOS CONTROL METHOD FOR BUILDING DEMOLITION

    Science.gov (United States)

    This presentation describes the preliminary results of the evaluations of the alternative asbestos control method for demolishing buildings containing asbestos, and are covered under the regulatory requirements of the Asbestos NESHAP. This abstract and presentation are based, at ...

  6. A statistical evaluation of factors influencing aerial survey results on brown bears

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report is a statistical evaluation of factors influencing aerial survey results on Brown Bears. The purpose of this study was to provide a statistical...

  7. Wayne Interim Storage Site annual environmental report for calendar year 1991, Wayne, New Jersey. [Wayne Interim Storage Site

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-09-01

    This document describes the envirormental monitoring program at the Wayne Interim Storage Site (WISS) and surrounding area, implementation of the program, and monitoring results for 1991. Environmental monitoring of WISS and surrounding area began in 1984 when Congress added the site to the US Department of Energy's (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP is a DOE program to decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation's atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. WISS is a National Priorities List site. The environmental monitoring program at WISS includes sampling networks for radon and thoron concentrations in air; external gamma radiation exposure; and radium-226, radium-228, thorium-232, and total uranium concentrations in surface water, sediment, and groundwater. Several nonradiological parameters are also measured in groundwater. Monitoring results are compared with applicable Environmental Protection Agency standards, DOE derived concentration guides, dose limits, and other requirements in DOE orders. Environmental standards are established to protect public health and the environment.

  8. Maywood Interim Storage Site annual environmental report for calendar year 1991, Maywood, New Jersey. [Maywood Interim Storage Site

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-09-01

    This document describes the environmental monitoring program at the Maywood Interim Storage Site (MISS) and surrounding area, implementation of the program, and monitoring results for 1991. Environmental monitoring of MISS began in 1984 when congress added the site to the US Department of Energy's (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP is a DOE program to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation's atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental monitoring program at MISS includes sampling networks for radon and thoron concentrations in air; external gamma radiation-exposure; and total uranium, radium-226, radium-228, thorium-232, and thorium-230 concentrations in surface water, sediment, and groundwater. Additionally, several nonradiological parameters are measured in surface water, sediment, and groundwater. Monitoring results are compared with applicable Environmental Protection Agency standards, DOE derived concentration guides (DCGs), dose limits, and other requirements in DOE orders. Environmental standards are established to protect public health and the environment.

  9. 75 FR 35510 - License Renewal Interim Staff Guidance Process, Revision 2 Notice of Availability

    Science.gov (United States)

    2010-06-22

    ... COMMISSION License Renewal Interim Staff Guidance Process, Revision 2 Notice of Availability AGENCY: Nuclear... license renewal interim staff guidance (LR-ISG) process. This revision is entitled, ``License Renewal... Renewal Interim Staff Guidance Process, Revision 1'' (ML091950069) (the previous LR-ISG process). FOR...

  10. 78 FR 56750 - Interim Staff Guidance on Environmental Issues Associated With New Reactors

    Science.gov (United States)

    2013-09-13

    ... COMMISSION Interim Staff Guidance on Environmental Issues Associated With New Reactors AGENCY: Nuclear... Staff Guidance (ISG) ESP/COL-ISG-026, ``Interim Staff Guidance on Environmental Issues ] Associated with... Notice: Draft Interim Staff Guidance on Environmental Issues Associated with New Reactors. ML12326A742...

  11. 46 CFR 308.302 - Issuance of interim binder; terms and conditions.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Issuance of interim binder; terms and conditions. 308... OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.302 Issuance of interim binder; terms and conditions. Upon acceptance of an application, an interim binder in form as set forth in § 308.3...

  12. 46 CFR 308.102 - Issuance of interim binder; terms and conditions; fees.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Issuance of interim binder; terms and conditions; fees... OPERATIONS WAR RISK INSURANCE War Risk Hull and Disbursements Insurance § 308.102 Issuance of interim binder; terms and conditions; fees. Upon acceptance of an application, an interim binder in the form set forth...

  13. [Results of a Representative Survey on the Psychosocial Evaluation Before Living Donor Kidney Transplantation in Germany].

    Science.gov (United States)

    de Zwaan, Martina; Erim, Yesim; Greif-Higer, Gertrud; Kröncke, Sylvia; Burgmer, Markus; Vitinius, Frank; Kunze, Sabine; Berth, Hendrik

    2017-06-01

    Aim Since there is no consensus about how to perform the predonation psychosocial evaluation of living kidney donor candidates, this is conducted differently in German transplant centers. Thus, the goal of the study was to learn more about how psychosocial evaluations are currently conducted in German transplant centers. Methods The psychosocial evaluators of the 38 transplant centers performing kidney transplantations in 2015 were contacted and asked to participate in an anonymous online survey. Results Psychosocial evaluators from 28 (75%) transplant centers responded. In only 30 (4%) of the evaluations contraindications for donation were reported. In most centers the psychosocial evaluation was performed after the completion of all medical tests. The evaluations were realized after only short waiting periods and were reported to be time-consuming. Financial reimbursement was mainly realized by internal cost allocation. In most centers the evaluators used semi-structured interviews. Still, there was limited consensus about structure and content of the psychosocial evaluation. Conclusion Standardization of the psychosocial evaluation process could be helpful to enable comparisons between transplant centers and to achieve equal opportunities for the potential living kidney donors and recipients. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Interim process report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Sellin, Patrick (ed.)

    2004-08-01

    This report is a documentation of buffer processes identified as relevant to the long-term safety of a KBS-3 repository. The report is part of the interim reporting of the safety assessment SR-Can, see further the Interim main report. The final SR-Can reporting will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of this report is to document the scientific knowledge of the processes to a level required for an adequate treatment in the safety assessment. The documentation is thus from a scientific point of not exhaustive since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of an assessment. The purpose is further to determine the handling of each process in the safety assessment and to demonstrate how uncertainties are taken care of, given the suggested handling. The process documentation in the SR 97 version of the Process report is a starting point for this SR-Can interim version. As further described in the Interim main report, the list of relevant processes has been reviewed and slightly extended by comparison to other databases. Furthermore, the backfill has been included as a system part of its own, rather than being described together with the buffer as in SR 97. Apart from giving an interim account of the documentation and handling of buffer processes in SR-Can, this report is meant to serve as a template for the forthcoming documentation of processes occurring in other parts of the repository system. A complete list of processes can be found in the Interim FEP report for the safety assessment SR-Can. All material presented in this document is preliminary in nature and will possibly be updated as the SR-Can project progresses.

  15. Application of Student t-test for evaluation of interlaboratory comparative tests results

    Directory of Open Access Journals (Sweden)

    K. V. Shatalov

    2016-01-01

    Full Text Available The results of interlaboratory comparative tests typically represent a small sample size. Therefore, to evaluate the quality of test results of laboratories participating in interlaboratory comparative tests, it is proposed to use Student t-test, which connects three main characteristics of small sample: the width of the confidence interval, the corresponding confidence probability and sample size. The examples of interlaboratory comparative tests of diesel show, that the use Student test allows to more objectively evaluate the quality of tests results of laboratories, in particular to identify and assess the results outside the confidence interval of the certified value of the sample for inspection. The calculation of average values of Student statistic for the aggregate test results allows to evaluate the quality of the laboratory, to range them, to form a ranking of laboratories on an objective basis.

  16. Reinforcement of a PMMA resin for interim fixed prostheses with silica nanoparticles.

    Science.gov (United States)

    Topouzi, Marianthi; Kontonasaki, Eleana; Bikiaris, Dimitrios; Papadopoulou, Lambrini; Paraskevopoulos, Konstantinos M; Koidis, Petros

    2017-05-01

    Fractures in long span provisional/interim restorations are a common complication. Adequate fracture toughness is necessary to resist occlusal forces and crack propagation, so these restorations should be constructed with materials of improved mechanical properties. The aim of this study was to investigate the possible reinforcement of neat silica nanoparticles and trietoxyvinylsilane-modified silica nanoparticles in a PMMA resin for fixed interim restorations. Composite PMMA-Silica nanoparticles powders were mixed with PMMA liquid and compact bar shaped specimens were fabricated according to the British standard BS EN ISO 127337:2005. The single-edge notched method was used to evaluate fracture toughness (three-point bending test), while the dynamic thermomechanical properties (Storage Modulus, Loss Modulus, tanδ) of a series of nanocomposites with different amounts of nanoparticles (0.25%, 0.50%, 0.75%, 1% w.t.) were evaluated. Statistical analysis was performed and the statistically significant level was set to pnanoparticles. Dynamic mechanical properties were also affected. By increasing the silica nanoparticles content an increase in Storage Modulus was recorded, while Glass Transition Temperature was shifted at higher temperatures. Under the limitations of this in-vitro study, it can be suggested that both neat silica nanoparticles and trietoxyvinylsilane-modified silica nanoparticles, especially at low concentrations, may enhance the overall performance of fixed interim prostheses, as can effectively increase the fracture toughness, the elastic modulus and the Glass Transition Temperature of PMMA resins used in fixed provisional restorations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Pilot field testing of Arctic engine oil in army combat/tactical vehicles at Fort Carson, Colorado and Fort Lewis, West Virginia. Interim report January 1977-June 1981

    Energy Technology Data Exchange (ETDEWEB)

    Tosh, J.D.; Alvarez, R.A.; Butler, W.E.; Owens, E.C.; Bowen, T.C.

    1982-07-01

    Military lube orders for combat and tactical equipment specify use of a single-viscosity grade lubricant with the grade depending on seasonal or climatic conditions. The use of this oil results in seasonal oil changes, regardless of the condition of the oil. Also, standard issue oils do not offer sufficient lubricant and engine protection over a wide range of ambient temperatures. Pilot field testing was conducted at Fort Carson, CO and Fort Lewis, WA. The objective of the testing was to evaluate the capability of MIL-L-46167 (5) arctic oil (OEA) to provide an interim solution to the lubrication problems being encountered. In addition, the data derived from the test were to be used as a basis for developing multigrade engine oils for Army tactical and combat equipment and to gain supplemental information covering the use of OEA lubricant over expanded temperature ranges.

  18. Evaluating the Dynamics of Aircraft Crew Skill Development by Using the Results of Discrete Exercise Marking

    Directory of Open Access Journals (Sweden)

    Lešinskis Aloizs

    2017-08-01

    Full Text Available Aircraft crew training corresponds to the interactive learning models of sensorimotor skill acquisition, and the dynamics of skill acquirement can be approximated by the exponential trend. A model of 5-grade assessment of separate exercises is offered. It helps to calculate a resulting evaluation, in accordance with which the progress level of a discrete exercise is evaluated. Such an evaluation forms one of the points for the analytical construction of a learning curve using the Gaussian method. Possible applications of the learning curve are covered.

  19. Evaluation of Satellite and Reanalysis Soil Moisture Products over Southwest China Using Ground-Based Measurements

    Directory of Open Access Journals (Sweden)

    Jian Peng

    2015-11-01

    Full Text Available Long-term global satellite and reanalysis soil moisture products have been available for several years. In this study, in situ soil moisture measurements from 2008 to 2012 over Southwest China are used to evaluate the accuracy of four satellite-based products and one reanalysis soil moisture product. These products are the Advanced Microwave Scanning Radiometer for the Earth observing system (AMSR-E, the Advanced Scatterometer (ASCAT, the Soil Moisture and Ocean Salinity (SMOS, the European Space Agency’s Climate Change Initiative soil moisture (CCI SM, and the European Centre for Medium-Range Weather Forecasts (ECMWF Interim Reanalysis (ERA-Interim. The evaluation of soil moisture absolute values and anomalies shows that all the products can capture the temporal dynamics of in situ soil moisture well. For AMSR-E and SMOS, larger errors occur, which are likely due to the severe effects of radio frequency interference (RFI over the test region. In general, the ERA-Interim (R = 0.782, ubRMSD = 0.035 m3/m3 and CCI SM (R = 0.723, ubRMSD = 0.046 m3/m3 perform the best compared to the other products. The accuracy levels obtained are comparable to validation results from other regions. Therefore, local hydrological applications and water resource management will benefit from the long-term ERA-Interim and CCI SM soil moisture products.

  20. UTILIZATION OF EVALUATION RESULTS IN LEGAL POLICY-MAKING AND ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Hellmut Wollmann

    2017-01-01

    Full Text Available The article is devoted to the analysis of evaluation method and its impact on legal policy development in governance, including in the area of law enforcement.The author outlines the importance of question whether, when and how the evaluation results of public policies, programs and measures has been utilized (or not utilized in policy making and policy implementation.In the pursuit of this guiding question the article will come in five steps.First, major variants of evaluation will be briefly presented particularly with an eye on their respective “utilization potential”.Second, different concepts will be sketched that have been forwarded to capture the utilization of social science generated knowledge by political, administrative and social actors. The author outlines a detailed description of types of evaluations: a retrospective, prelimi-nary, ongoing, interactive, – as well as existing concepts of application of its results.Third, looking at Germany, Switzerland and the European Union as “cases in point” perti-ent research findings will be discussed. The article also subjected to a detailed analysis of the experience of Germany, Switzerland and the European Union in the field of utilization of evaluation results.Fourth, a summary and conclusion will be given.Fifth, some remarks on pertinent research needs will be made.The author comes to the conclusion that that the rate of the utilization of evaluation-generated knowledge has so far turned out be, by and large, scarce. The author says that re-garding the politically crucial decisions the political rationality and its underlying political will of the decision-makers prevail while concerning less important decisions evaluation-generated evidence does show some effect and, hence, a dose of scientific rationality comes to the fore.There is also a need for further research on the subject of how should (and should not use assessment results when making legal and political decisions.

  1. Interim Project Financing in the Nigerian Construction Industry ...

    African Journals Online (AJOL)

    Out of the 47 variables identified through a structured survey, that can adversely affect the construction industry in Nigeria, “the difficulties in securing credit for interim construction finance on reasonable terms”, is ranked as the 6th most important factor, while “client's unwillingness to pay for advance for mobilization and ...

  2. Single-shell tank interim stabilization project plan

    Energy Technology Data Exchange (ETDEWEB)

    Ross, W.E.

    1998-05-11

    This project plan establishes the management framework for conduct of the TWRS Single-Shell Tank Interim Stabilization completion program. Specifically, this plan defines the mission needs and requirements; technical objectives and approach; organizational structure, roles, responsibilities, and interfaces; and operational methods. This plan serves as the project executional baseline.

  3. Single Shell Tank (SST) Interim Stabilization Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    VLADIMIROFF, D.T.; BOYLES, V.C.

    2000-05-22

    This project plan establishes the management framework for the conduct of the CHG Single-Shell Tank Interim Stabilization completion program. Specifically, this plan defines the mission needs and requirements; technical objectives and approach; organization structure, roles, responsibilities, and interfaces; and operational methods. This plan serves as the project executional baseline.

  4. Investigation of adult stainless steel crown longevity as an interim restoration in pediatric patients.

    Science.gov (United States)

    Discepolo, Keri; Sultan, Michael

    2017-07-01

    Preformed metal crowns, also known as stainless steel crowns (SSC), are utilized for providing full coverage to young permanent teeth and have been used extensively as restorations of primary teeth for approximately 65 years. Evaluate permanent tooth SSC longevity as an interim restoration for teeth requiring full coverage restoration in pediatric patients. Retrospective chart review from 2006 through 2014 in a hospital-based dental clinic for permanent tooth pre-fabricated crown longevity. One hundred and fifty-five SSCs were evaluated with regard to: age of patient at restoration placement, diagnoses, and duration of crown service. Duration service was further categorized as successful or failed. Of 155 SSCs, 137 were considered successfully functioning. Total failures were 18. The overall combined success rate for the study group was observed to be 88% with an average service period of 45.18 months. Significant success was noted in patients less than 9 years of age, and significant failure was observed in patients 12 years and older. Stainless steel crowns are a viable option for interim restoration needs, with an 88% overall success rate during an average service period of 45.18 months. © 2016 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Flexible methods for segmentation evaluation: Results from CT-based luggage screening

    Science.gov (United States)

    Karimi, Seemeen; Jiang, Xiaoqian; Cosman, Pamela; Martz, Harry

    2017-01-01

    BACKGROUND Imaging systems used in aviation security include segmentation algorithms in an automatic threat recognition pipeline. The segmentation algorithms evolve in response to emerging threats and changing performance requirements. Analysis of segmentation algorithms’ behavior, including the nature of errors and feature recovery, facilitates their development. However, evaluation methods from the literature provide limited characterization of the segmentation algorithms. OBJECTIVE To develop segmentation evaluation methods that measure systematic errors such as oversegmentation and undersegmentation, outliers, and overall errors. The methods must measure feature recovery and allow us to prioritize segments. METHODS We developed two complementary evaluation methods using statistical techniques and information theory. We also created a semi-automatic method to define ground truth from 3D images. We applied our methods to evaluate five segmentation algorithms developed for CT luggage screening. We validated our methods with synthetic problems and an observer evaluation. RESULTS Both methods selected the same best segmentation algorithm. Human evaluation confirmed the findings. The measurement of systematic errors and prioritization helped in understanding the behavior of each segmentation algorithm. CONCLUSIONS Our evaluation methods allow us to measure and explain the accuracy of segmentation algorithms. PMID:24699346

  6. A Two-Generational Child-Focused Program Enhanced with Employment Services: Eighteen-Month Impacts from the Kansas and Missouri Sites of the Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project

    Science.gov (United States)

    Hsueh, JoAnn; Jacobs, Erin; Farrell, Mary

    2011-01-01

    Children living in poverty face considerable developmental risks. This report presents interim results from an evaluation of parental employment and educational services delivered within a two-generational, early childhood program targeting low-income families who are expecting a child or who have a child under age 3. This study is part of the…

  7. A Two-Generational Child-Focused Program Enhanced with Employment Services: Eighteen-Month Impacts from the Kansas and Missouri Sites of the Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project. Executive Summary

    Science.gov (United States)

    Hsueh, JoAnn; Jacobs, Erin; Farrell, Mary

    2011-01-01

    Children living in poverty face considerable developmental risks. This report presents interim results from an evaluation of parental employment and educational services delivered within a two-generational, early childhood program targeting low-income families who are expecting a child or who have a child under age 3. This study is part of the…

  8. Moisture Flux across Colombia in the new generation reanalysis ERA-Interim

    Science.gov (United States)

    Arenas Suárez, T.; Hoyos, I. C.; Rodriguez, B.

    2013-12-01

    The complex regional topography in Northern of South America plays an important role in transport atmospheric processes. The terrain structure controls the moisture flows by strengthening orographic pattern formation of rainfall and convective mesoscale fluxes. In Colombia, the orographic complexity is amplified by the division of the Andes in three branches, which added to the nearness to marine sources and the influence of global climatic phenomena, results in a great spatial and temporal variability of climate that is difficult to capture by modeling. In this contribution we assess the regional representation of moisture flux transport mechanisms from the new generation of reanalysis ERA-Interim, which offers qualitative advantages respect to other climate data sets in tropical areas especially respect to terrain elevation, closure of hydrological cycle representation and over-estimations in precipitation and moisture transport. Temporal and spatial variability of moisture flux divergence (MFD) field are explored in connection with other hydrological variables and global climate phenomena of regional impact. The seasonal moisture transport is mostly driven by the Intertropical Convergence Zone displacement, with dominant sources from the Caribbean Sea and Southeast Pacific whereas the Colombian Pacific is a permanent sink of moisture. Consistently with previous works, the moisture transport occurs mainly by low-level jets, but, contrary to what previous reports state, local humidity has several sources, for instance, the moisture transport over continental area of colombian Pacific has a strong contribution from the Caribbean Sea that intraseasonally is presented in major proportion than the Choco Jet's transport. The spatiotemporal patterns of MFD variability were evaluated through an EOF analysis whose main components are associated in order with: the North Tropical Atlantic and the El Nio Southern Oscillation.

  9. NASA-easyJet Collaboration on the Human Factors Monitoring Program (HFMP) Study, Second Interim Report

    Science.gov (United States)

    Srivastava, Ashok N.; Barton, Phil

    2012-01-01

    This is the second interim report jointly prepared by NASA and easyJet on the work performed under the agreement to collaborate on a study of the factors entailed in flight- and cabin-crew fatigue and decreases in performance associated with fatigue. The objective of this Agreement is to generate reliable procedures that aid in understanding the levels and characteristics of flight- and cabin-crew fatigue factors, both latent and proximate, whose confluence will likely result in unacceptable crew performance. This study entails the analyses of numerical and textual data collected during operational flights.

  10. Optimal Futility Interim Design: A Predictive Probability of Success Approach with Time-to-Event Endpoint.

    Science.gov (United States)

    Tang, Zhongwen

    2015-01-01

    An analytical way to compute predictive probability of success (PPOS) together with credible interval at interim analysis (IA) is developed for big clinical trials with time-to-event endpoints. The method takes account of the fixed data up to IA, the amount of uncertainty in future data, and uncertainty about parameters. Predictive power is a special type of PPOS. The result is confirmed by simulation. An optimal design is proposed by finding optimal combination of analysis time and futility cutoff based on some PPOS criteria.

  11. Process Evaluation Results from an Environmentally Focused Worksite Weight Management Study

    Science.gov (United States)

    DeJoy, David M.; Wilson, Mark G.; Padilla, Heather M.; Goetzel, Ron Z.; Parker, Kristin B.; Della, Lindsay J.; Roemer, Enid C.

    2012-01-01

    There is currently much interest in exploring environmental approaches to combat weight gain and obesity. This study presents process evaluation results from a workplace-based study that tested two levels of environmentally focused weight management interventions in a manufacturing setting. The moderate treatment featured a set of relatively…

  12. The Dutch Review Process for Evaluating the Quality of Psychological Tests: History, Procedure, and Results

    Science.gov (United States)

    Evers, Arne; Sijtsma, Klaas; Lucassen, Wouter; Meijer, Rob R.

    2010-01-01

    This article describes the 2009 revision of the Dutch Rating System for Test Quality and presents the results of test ratings from almost 30 years. The rating system evaluates the quality of a test on seven criteria: theoretical basis, quality of the testing materials, comprehensiveness of the manual, norms, reliability, construct validity, and…

  13. A System Evaluation Theory Analyzing Value and Results Chain for Institutional Accreditation in Oman

    Science.gov (United States)

    Paquibut, Rene Ymbong

    2017-01-01

    Purpose: This paper aims to apply the system evaluation theory (SET) to analyze the institutional quality standards of Oman Academic Accreditation Authority using the results chain and value chain tools. Design/methodology/approach: In systems thinking, the institutional standards are connected as input, process, output and feedback and leads to…

  14. Online Student Evaluation Improves Course Experience Questionnaire Results in a Physiotherapy Program

    Science.gov (United States)

    Tucker, Beatrice; Jones, Sue; Straker, Leon

    2008-01-01

    This paper reports the use of an online student evaluation system, Course Experience on the Web (CEW), in a physiotherapy program to improve their Course Experience Questionnaire (CEQ) results. CEW comprises a course survey instrument modeled on the CEQ and a tailored unit survey instrument. Closure of the feedback loop is integral in the CEW…

  15. SOFT TISSUE RECONSTRUCTION OF THE LOWER EXTREMITY: EVALUATION OF SURGICAL RESULTS IN 15 PATIENTS

    OpenAIRE

    Fatemi, M.J.; M Baghaei; M Soroush

    2003-01-01

    Introduction: There are general guidelines for reconstruction of complex wounds of the Lower extremity. The goal in treatment of these wounds is to preserve a limb that will be more functional than an amputation. Material & Methods: In this study, we evaluate our results in 15 patients with extensive wounds in lower extremities (April - 1998 to march - 2001). Results: The average age of the patients was 31.20 with an age range between 9 to 61 years. Majority of the patients were...

  16. Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin’s Lymphoma

    Science.gov (United States)

    Johnson, Peter; Federico, Massimo; Kirkwood, Amy; Fosså, Alexander; Berkahn, Leanne; Carella, Angelo; d’Amore, Francesco; Enblad, Gunilla; Franceschetto, Antonella; Fulham, Michael; Luminari, Stefano; O’Doherty, Michael; Patrick, Pip; Roberts, Thomas; Sidra, Gamal; Stevens, Lindsey; Smith, Paul; Trotman, Judith; Viney, Zaid; Radford, John; Barrington, Sally

    2016-01-01

    Background We tested interim positron-emission tomography–computed tomography (PET-CT) as a measure of early response to chemotherapy in order to guide treatment for patients with advanced Hodgkin’s lymphoma. Methods Patients with newly diagnosed advanced classic Hodgkin’s lymphoma underwent a baseline PET-CT scan, received two cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy, and then underwent an interim PET-CT scan. Images were centrally reviewed with the use of a 5-point scale for PET findings. Patients with negative PET findings after two cycles were randomly assigned to continue ABVD (ABVD group) or omit bleomycin (AVD group) in cycles 3 through 6. Those with positive PET findings after two cycles received BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone). Radiotherapy was not recommended for patients with negative findings on interim scans. The primary outcome was the difference in the 3-year progression-free survival rate between randomized groups, a noninferiority comparison to exclude a difference of 5 or more percentage points. Results A total of 1214 patients were registered; 937 of the 1119 patients (83.7%) who underwent an interim PET-CT scan according to protocol had negative findings. With a median follow-up of 41 months, the 3-year progression-free survival rate and overall survival rate in the ABVD group were 85.7% (95% confidence interval [CI], 82.1 to 88.6) and 97.2% (95% CI, 95.1 to 98.4), respectively; the corresponding rates in the AVD group were 84.4% (95% CI, 80.7 to 87.5) and 97.6% (95% CI, 95.6 to 98.7). The absolute difference in the 3-year progression-free survival rate (ABVD minus AVD) was 1.6 percentage points (95% CI, −3.2 to 5.3). Respiratory adverse events were more severe in the ABVD group than in the AVD group. BEACOPP was given to the 172 patients with positive findings on the interim scan, and 74.4% had negative findings on a third

  17. Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test

    Directory of Open Access Journals (Sweden)

    Eddy C. Hsueh

    2017-08-01

    Full Text Available Abstract Background A 31-gene expression profile (GEP test that provides risk classification of cutaneous melanoma (CM patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of the GEP performance in patients enrolled in two clinical registries. Methods Three-hundred twenty two CM patients enrolled in the EXPAND (NCT02355587 and INTEGRATE (NCT02355574 registries met the criteria of age ≥ 16 years, successful GEP result and ≥1 follow-up visit for inclusion in this interim analysis. Primary endpoints were recurrence-free (RFS, distant metastasis-free (DMFS, and overall survival (OS. Results Median follow-up was 1.5 years for event-free patients. Median age for subjects was 58 years (range 18–87 and median Breslow thickness was 1.2 mm (range 0.2–12.0. Eighty-eight percent (282/322 of cases had stage I/II disease and 74% (237/322 had a SLN biopsy. Seventy-seven percent (248/322 had class 1 molecular profiles. 1.5-year RFS, DMFS, and OS rates were 97 vs. 77%, 99 vs. 89%, and 99 vs. 92% for class 1 vs. class 2, respectively (p < 0.0001 for each. Multivariate Cox regression showed Breslow thickness, mitotic rate, and GEP class to significantly predict recurrence (p < 0.01, while tumor thickness was the only significant predictor of distant metastasis and overall survival in this interim analysis. Conclusions Interim analysis of patient outcomes from a combined prospective cohort supports the 31-gene GEP’s ability to stratify early-stage CM patients into two groups with significantly different metastatic risk. RFS outcomes in this real-world cohort are consistent with previously published analyses with retrospective specimens. GEP testing complements current clinicopathologic features and increases identification of high-risk patients. Trial registration ClinicalTrials.gov, NCT02355574  and NCT02355587  

  18. Communicating Ocean Sciences to Informal Audiences (COSIA): Interim Evaluation Report

    Science.gov (United States)

    St. John, Mark; Phillips, Michelle; Smith, Anita; Castori, Pam

    2009-01-01

    Communicating Ocean Sciences to Informal Audiences (COSIA) is a National Science Foundation (NSF)-funded project consisting of seven long-term three-way partnerships between the Lawrence Hall of Science (LHS) and an informal science education institution (ISEI) partnered with an institution of higher education (IHE). Together, educators from the…

  19. Evaluation of a class of possible simple interim management ...

    African Journals Online (AJOL)

    One of the candidates was subsequently selected by a joint meeting of scientists, industry and Ministry officials in February 1998 and served as the basis for scientific recommendations for the TAC for the hake resource for the following three years. Keywords: abundance, Cape hake, Management Procedure, Namibia, ...

  20. One-year results of a prospective randomized, evaluator-blinded, multicenter study comparing TVT and TVT Secur.

    Science.gov (United States)

    Andrada Hamer, Maria; Larsson, Per-Göran; Teleman, Pia; Bergqvist, Christina Eten; Persson, Jan

    2013-02-01

    The aim of this prospective randomized multicenter study was to compare retropubic tension-free vaginal tape (TVT) with TVT Secur in terms of efficacy and safety. We set out to enrol 280 stress urinary incontinent (SUI) women with a half-time interim analysis of short-term cure and adverse events. The short-term results have previously been published. Of the 133 randomized women, 125 underwent surgery, and 121 (TVT n = 61, TVT Secur n = 60) were available for follow-up 1 year postsurgery. No significant differences were found between groups regarding demographics or incontinence grade. One year after surgery, both subjective and objective cure rates were significantly lower for TVT Secur than for TVT (subjective cure: TVT 98 %, TVT Secur 80 %, p = 0.03; objective cure: TVT 94 %, TVT Secur 71 % for cough test, p = 0.01; TVT 76 %, TVT Secur 58 % for pad test, p = 0.05 ). Three major complications occurred in the TVT Secur group: one tape erosion into the urethra, one tape inadvertently placed into the bladder, and one immediate postoperative bleeding due to injury to the corona mortis. No major complications occurred in the TVT group. No significant differences were found between groups regarding peroperative bleeding, hospital stay, urge symptoms, residual urinary volume, subjective bladder emptying problems, postoperative urinary tract infections, and minor complications. The TVT Secur group used more antimuscarine medication after surgery than the TVT group (p = 0.03). Median time for surgery was 13 and 22 min for TVT Secur and TVT, respectively (p TVT Secur procedure had significantly inferior subjective and objective cure rates compared with the retropubic TVT procedure. Three serious adverse events occurred in the TVT Secur group. We therefore discourage further use of TVT Secur.

  1. Aanbevelingen voor succesvol interim-management : Welke handelen van de interim-manager leidt tot tevredenheid van zijn opdrachtgever?

    NARCIS (Netherlands)

    Schaveling, J.; Muijen, van J.J.; Montfort, van K.

    2010-01-01

    Wat maakt de opdrachtgever van interim-managers tevreden? In de literatuur worden verschillende factoren genoemd en ook de betrokkenen zelf hebben er ideeën over, maar welk gedrag doet er nu werkelijk toe? Op basis van een empirisch onderzoek wordt deze vraag beantwoord. Een literatuurstudie vormt

  2. Methods for evaluation of medical care other than credentialing. Cost, experience, and results.

    Science.gov (United States)

    Ebert, P A

    1990-08-01

    Unfortunately, the majority of studies proposed to evaluate a physician's capabilities, such as effectiveness programs, outcome research, and hospital evaluation, do not focus directly on the individual practitioner. The certifying process, although imperfect, still offers the best method of evaluation. The other evaluation methods will need additional refinement to be able to individually analyze a specific physician's performance and determine whether he or she is truly providing the highest quality care. Physicians are being asked to document the effectiveness of their clinical decision making. On the surface this seems so simple, and in some areas where the outcome is either life or death or a specific yes or no type of answer, many have the capability to come forth with some realistic documentation. However, today's society is focused on health and the perfect outcome, and many nonlife-threatening therapies are evaluated by a patient's unrealistic expectation. Thus, the same result may be interpreted differently in one geographic area or by patients with different expectations. The biggest mistake would be to believe that outcome studies can be used to reduce cost. There may be some initial reduction or delays in treatment that suggest an immediate reduction of cost, the so-called sentinel effect, but no information or evidence indicates that these effects can be expanded without actually reducing needed health care services. In fact, the delays or obstruction to entering the health-care system experienced by many individuals often lead to more costly and less effective care with suboptimal results.

  3. Public library consumer health information pilot project: results of a National Library of Medicine evaluation.

    Science.gov (United States)

    Wood, F B; Lyon, B; Schell, M B; Kitendaugh, P; Cid, V H; Siegel, E R

    2000-10-01

    In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was

  4. Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin's Lymphoma.

    Science.gov (United States)

    Johnson, Peter; Federico, Massimo; Kirkwood, Amy; Fosså, Alexander; Berkahn, Leanne; Carella, Angelo; d'Amore, Francesco; Enblad, Gunilla; Franceschetto, Antonella; Fulham, Michael; Luminari, Stefano; O'Doherty, Michael; Patrick, Pip; Roberts, Thomas; Sidra, Gamal; Stevens, Lindsey; Smith, Paul; Trotman, Judith; Viney, Zaid; Radford, John; Barrington, Sally

    2016-06-23

    -free survival rate was 67.5% and the overall survival rate 87.8%. A total of 62 patients died during the trial (24 from Hodgkin's lymphoma), for a 3-year progression-free survival rate of 82.6% and an overall survival rate of 95.8%. Although the results fall just short of the specified noninferiority margin, the omission of bleomycin from the ABVD regimen after negative findings on interim PET resulted in a lower incidence of pulmonary toxic effects than with continued ABVD but not significantly lower efficacy. (Funded by Cancer Research UK and Others; ClinicalTrials.gov number, NCT00678327.).

  5. SLIGHTLY IRRADIATED FUEL (SIF) INTERIM DISPOSITION PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    NORTON SH

    2010-02-23

    CH2M HILL Plateau Remediation Company (CH2M HILL PRC) is proud to submit the Slightly Irradiated Fuel (SIF) Interim Disposition Project for consideration by the Project Management Institute as Project of the Year for 2010. The SIF Project was a set of six interrelated sub-projects that delivered unique stand-alone outcomes, which, when integrated, provided a comprehensive and compliant system for storing high risk special nuclear materials. The scope of the six sub-projects included the design, construction, testing, and turnover of the facilities and equipment, which would provide safe, secure, and compliant Special Nuclear Material (SNM) storage capabilities for the SIF material. The project encompassed a broad range of activities, including the following: Five buildings/structures removed, relocated, or built; Two buildings renovated; Structural barriers, fencing, and heavy gates installed; New roadways and parking lots built; Multiple detection and assessment systems installed; New and expanded communication systems developed; Multimedia recording devices added; and A new control room to monitor all materials and systems built. Project challenges were numerous and included the following: An aggressive 17-month schedule to support the high-profile Plutonium Finishing Plant (PFP) decommissioning; Company/contractor changeovers that affected each and every project team member; Project requirements that continually evolved during design and construction due to the performance- and outcome-based nature ofthe security objectives; and Restrictions imposed on all communications due to the sensitive nature of the projects In spite of the significant challenges, the project was delivered on schedule and $2 million under budget, which became a special source of pride that bonded the team. For years, the SIF had been stored at the central Hanford PFP. Because of the weapons-grade piutonium produced and stored there, the PFP had some of the tightest security on the Hanford

  6. Audit requirements for institutions of higher education and other nonprofit organizations--Department of Commerce. Interim final rule with request for comments.

    Science.gov (United States)

    1991-04-19

    The Department of Commerce is implementing Office of Management and Budget (OMB) guidance provided in Circular A-133, "Audits of Institutions of Higher Education and Other Nonprofit Organizations." As a result of this interim final rule, institutions of higher education and other nonprofit organizations that receive Federal assistance are required to periodically perform audits and submit the audit reports to the Federal government. This interim final rule establishes uniform audit requirements applicable to these organizations and defines the Department's responsibilities for implementing and monitoring these requirements.

  7. Endoanal ultrasound evaluation of anorectal diseases and disorders: Technique, indications, results and limitations

    Energy Technology Data Exchange (ETDEWEB)

    Saranovic, Djordjije [University of Belgrade, Radiology Department, Institute for Digestive Diseases, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia)]. E-mail: crvzve4@yahoo.com; Barisic, Goran [Department for Colorectal Surgery, Institute for Digestive Disease, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia); Krivokapic, Zoran [Department for Colorectal Surgery, Institute for Digestive Disease, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia); Masulovic, Dragan [University of Belgrade, Radiology Department, Institute for Digestive Diseases, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia); Djuric-Stefanovic, Aleksandra [University of Belgrade, Radiology Department, Institute for Digestive Diseases, I Surgical Clinic, Clinical Center of Serbia, Koste Todorovica 6, 11000 Belgrade (Serbia)

    2007-03-15

    Imaging of the rectum, anorectal junction and surrounding tissues is both difficult and technically challenging. CT and conventional barium studies offer limited information in local staging of rectal and perirectal neoplasms, anal carcinomas and extension perianal fistulas in patients with inflamamatory bowel disease, or in evaluating patients with fecal incontinence. During past decade, sonography and MR imaging have resulted in significant improvement in the imaging of rectal and perirectal and anal and perianal disease. The aim of this article is to review possibility of the EAUS in the evaluation both normal anal anatomy and anorectal disease and disorders (anal carcinoma, sphincter defects, anal fistulas, perianal abscesses and other pathological conditions)

  8. Statistical evaluation of characteristic SDDLV-induced stress resultants to discriminate between undamaged and damaged elements

    DEFF Research Database (Denmark)

    Hansen, Lasse Majgaard; Johansen, Rasmus Johan; Ulriksen, Martin Dalgaard

    2015-01-01

    alternately to an undamaged reference model with known stiffness matrix, hereby, theoretically, yielding characteristic stress resultants approaching zero in the damaged elements. At present, the discrimination between potentially damaged elements and undamaged ones is typically conducted on the basis...... of modified characteristic stress resultants, which are compared to a pre-defined tolerance value, without any thorough statistical evaluation. In the present paper, it is tested whether three widely-used statistical pattern-recognition-based damage-detection methods can provide an effective statistical...... evaluation of the characteristic stress resultants, hence facilitating general discrimination between damaged and undamaged elements. The three detection methods in question enable outlier analysis on the basis of, respectively, Euclidian distance, Hotelling’s statistics, and Mahalanobis distance. The study...

  9. Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 3. Alternatives for interim storage and transportation

    Energy Technology Data Exchange (ETDEWEB)

    1976-05-01

    Volume III of the five-volume report contains information on alternatives for interim storage and transportation. Section titles are: interim storage of spent fuel elements; interim storage of chop-leach fuel bundle residues; tank storage of high-level liquid waste; interim storage of solid non-high-level wastes; interim storage of solidified high-level waste; and, transportation alternatives. (JGB)

  10. REVIEW OF FAST FLUX TEST FACILITY (FFTF) FUEL EXPERIMENTS FOR STORAGE IN INTERIM STORAGE CASKS (ISC)

    Energy Technology Data Exchange (ETDEWEB)

    CHASTAIN, S.A.

    2005-10-24

    Appendix H, Section H.3.3.10.11 of the Final Safety Analysis Report (FSAR), provides the limits to be observed for fueled components authorized for storage in the Fast Flux Test Facility (FFTF) spent fuel storage system. Currently, the authorization basis allows standard driver fuel assemblies (DFA), as described in the FSAR Chapter 17, Section 17.5.3.1, to be stored provided decay power per assembly is {le} 250 watts, post-irradiation time is four years minimum, average assembly burn-up is 150,000 MWD/MTHM maximum and the pre-irradiation enrichment is 29.3% maximum (per H.3.3.10.11). In addition, driver evaluation (DE), core characterizer assemblies (CCA), and run-to-cladding-breach (RTCB) assemblies are included based on their similarities to a standard DFA. Ident-69 pin containers with fuel pins from these DFAs can also be stored. Section H.3.3.10.11 states that fuel types outside the specification criteria above will be addressed on a case-by-case basis. There are many different types of fuel and blanket experiments that were irradiated in the FFTF which now require offload to the spent fuel storage system. Two reviews were completed for a portion of these special type fuel components to determine if placement into the Core Component Container (CCC)/Interim Storage Cask (ISC) would require any special considerations or changes to the authorization basis. Project mission priorities coupled with availability of resources and analysts prevented these evaluations from being completed as a single effort. Areas of review have included radiological accident release consequences, radiological shielding adequacy, criticality safety, thermal limits, confinement, and stress. The results of these reviews are available in WHC-SD-FF-RPT-005, Rev. 0 and 1, ''Review of FFTF Fuel Experiments for Storage at ISA'', (Reference I), which subsequently allowed a large portion of these components to be included in the authorization basis (Table H.3.3-21). The

  11. Validation of a new SAFRAN-based gridded precipitation product for Spain and comparisons to Spain02 and ERA-Interim

    Science.gov (United States)

    Quintana-Seguí, Pere; Turco, Marco; Herrera, Sixto; Miguez-Macho, Gonzalo

    2017-04-01

    Offline land surface model (LSM) simulations are useful for studying the continental hydrological cycle. Because of the nonlinearities in the models, the results are very sensitive to the quality of the meteorological forcing; thus, high-quality gridded datasets of screen-level meteorological variables are needed. Precipitation datasets are particularly difficult to produce due to the inherent spatial and temporal heterogeneity of that variable. They do, however, have a large impact on the simulations, and it is thus necessary to carefully evaluate their quality in great detail. This paper reports the quality of two high-resolution precipitation datasets for Spain at the daily time scale: the new SAFRAN-based dataset and Spain02. SAFRAN is a meteorological analysis system that was designed to force LSMs and has recently been extended to the entirety of Spain for a long period of time (1979/1980-2013/2014). Spain02 is a daily precipitation dataset for Spain and was created mainly to validate regional climate models. In addition, ERA-Interim is included in the comparison to show the differences between local high-resolution and global low-resolution products. The study compares the different precipitation analyses with rain gauge data and assesses their temporal and spatial similarities to the observations. The validation of SAFRAN with independent data shows that this is a robust product. SAFRAN and Spain02 have very similar scores, although the latter slightly surpasses the former. The scores are robust with altitude and throughout the year, save perhaps in summer when a diminished skill is observed. As expected, SAFRAN and Spain02 perform better than ERA-Interim, which has difficulty capturing the effects of the relief on precipitation due to its low resolution. However, ERA-Interim reproduces spells remarkably well in contrast to the low skill shown by the high-resolution products. The high-resolution gridded products overestimate the number of precipitation days

  12. Quantitative method for evaluation of aesthetic results after laser treatment for birthmarks.

    Science.gov (United States)

    Szychta, Pawel; Al-Nakib, Khalil; Anderson, Will; Stewart, Ken; Quaba, Awf

    2013-11-01

    Subjective assessment of results after laser treatment for birthmarks does not provide a validated method for clinicians. Previous reports concerning objective evaluation using L*a*b color coordinates were only partially successful due to difficulties in standardizing and comparing colors from pre- and posttreatment photographs. The study aimed to present a reliable and clinically applicable method of aesthetic result assessment after laser treatment for birthmarks. All 48 patients, included in the study, were treated for birthmarks on the face or neck using laser. Each pre- and posttreatment photograph was subjected to triple objective comparative assessment of color fading with use of a computer program, as well as to subjective evaluation by three core physicians and three laypeople. Objective analysis was based on an innovative method using combined L*a*b and hue saturation value color coordinates. Accuracy was higher between objective assessment with the computer program and subjective evaluation by core physicians than by laypeople. Repeatability of results was higher with the use of the computer program than among core physicians or among laypeople. In conclusion, our method may be considered for objective assessment of the results after laser treatment of vascular and pigmented birthmarks.

  13. Evaluating outcomes of palliative photodynamic therapy: instrument development and preliminary results

    Science.gov (United States)

    Goodell, Teresa T.; Bargo, Paulo R.; Jacques, Steven L.

    2002-06-01

    Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

  14. INTERIM STORAGE AND LONG TERM DISPOSAL OF RESEARCH REACTOR SPENT FUEL

    Energy Technology Data Exchange (ETDEWEB)

    Vinson, D

    2006-08-22

    Aluminum clad research reactor spent nuclear fuel (SNF) is currently being consolidated in wet storage basins (pools). Approximately 20 metric tons (heavy metal) of aluminum-based spent nuclear fuel (Al-SNF) is being consolidated for treatment, packaging, interim storage, and preparation for ultimate disposal in a geologic repository. The storage and disposal of Al-SNF are subject to requirements that provide for safety and acceptable radionuclide release. The options studied for interim storage of SNF include wet storage and dry storage. Two options have also been studied to develop the technical basis for the qualification and repository disposal of aluminum spent fuel. The two options studied include Direct Disposal and Melt-Dilute treatment. The implementation of these options present relative benefits and challenges. Both the Direct Disposal and the Melt-Dilute treatment options have been developed and their technical viability assessed. Adaptation of the melt-dilute technology for the treatment of spent fuel offers the benefits of converting the spent fuel into a proliferation resistant form and/or significantly reducing the volume of the spent fuel. A Mobile Melt-Dilute system concept has emerged to realize these benefits and a prototype system developed. The application of the melt-dilute technology for the treatment of legacy nuclear materials has been evaluated and also offers the promise for the safe disposal of these materials.

  15. Can routine office-based audiometry predict cochlear implant evaluation results?

    Science.gov (United States)

    Gubbels, Samuel P; Gartrell, Brian C; Ploch, Jennifer L; Hanson, Kevin D

    2017-01-01

    Determining cochlear implant candidacy requires a specific sentence-level testing paradigm in best-aided conditions. Our objective was to determine if findings on routine audiometry could predict the results of a formal cochlear implant candidacy evaluation. We hypothesize that findings on routine audiometry will accurately predict cochlear implant evaluation results in the majority of candidates. Retrospective, observational, diagnostic study. The charts of all adult patients who were evaluated for implant candidacy at a tertiary care center from June 2008 through June 2013 were included. Routine, unaided audiologic measures (pure-tone hearing thresholds and recorded monosyllabic word recognition testing) were then correlated with best-aided sentence-level discrimination testing (using either the Hearing in Noise Test or AzBio sentences test). The degree of hearing loss at 250 to 4,000 Hz and monosyllabic word recognition scores significantly correlated with sentence-level word discrimination test results. Extrapolating from this association, we found that 86% of patients with monosyllabic word recognition scores at or below 32% (or 44% for patients with private insurance) would meet candidacy requirements for cochlear implantation. Routine audiometric findings can be used to identify patients who are likely to meet cochlear implant candidacy upon formal testing. For example, patients with pure-tone thresholds (250, 500, 1,000 Hz) of ≥75 dB and/or a monosyllabic word recognition test score of ≤40% have a high likelihood of meeting candidacy criteria. Utilization of these predictive patterns during routine audiometric evaluation may assist hearing health professionals in deciding when to refer patients for a formal cochlear implant evaluation. 4 Laryngoscope, 127:216-222, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  16. Audio segmentation of broadcast news in the Albayzin-2010 evaluation: overview, results, and discussion

    Directory of Open Access Journals (Sweden)

    Butko Taras

    2011-01-01

    Full Text Available Abstract Recently, audio segmentation has attracted research interest because of its usefulness in several applications like audio indexing and retrieval, subtitling, monitoring of acoustic scenes, etc. Moreover, a previous audio segmentation stage may be useful to improve the robustness of speech technologies like automatic speech recognition and speaker diarization. In this article, we present the evaluation of broadcast news audio segmentation systems carried out in the context of the Albayzín-2010 evaluation campaign. That evaluation consisted of segmenting audio from the 3/24 Catalan TV channel into five acoustic classes: music, speech, speech over music, speech over noise, and the other. The evaluation results displayed the difficulty of this segmentation task. In this article, after presenting the database and metric, as well as the feature extraction methods and segmentation techniques used by the submitted systems, the experimental results are analyzed and compared, with the aim of gaining an insight into the proposed solutions, and looking for directions which are promising.

  17. Evaluation and analysis of uncertainty in tensile experiment results of modified PPR at elevated temperature

    Science.gov (United States)

    Xiang, Yu; Zhonghua, Su; Jinhua, Leng; Teng, Yun

    2017-08-01

    A high temperature tensile experiment of modified random copolymerized polypropylene was carried out by ASTM D 638-2014. It analyzed the factors influencing the accuracy of the high temperature mechanical properties of modified random copolymer polypropylene and discussed the causes of the uncer-tainty of measurement standards from the sample size measurement, the indication error of force value of experiment machines, its calibration, data acquisition of the experimental software, the temperature control, the numerical correction, and the material nonuniformity, etc. According to JJF 1059.1-2012, class A and class B evaluation were conducted on the above-mentioned uncertainty components, and all the uncertainty components were synthesized. By analyzing the uncertainty of the measurement results, this paper provides a reference for evaluating the uncertainty of the same type of measurement results.

  18. Automated array assembly, Phase II. Interim report

    Energy Technology Data Exchange (ETDEWEB)

    D' Aiello, R. V.

    1979-01-01

    The work conducted during a 1-year program designed to establish the technological readiness and provide verification for the elements of a manufacturing sequence which would ultimately be suitable for the large-scale production of silicon solar-array modules at a cost of less than $500/peak kW is summarized. A detailed description of the development and experimental verification for individual process steps is given. The results of a detailed experimental study and evaluation of the factors which influence the performance of ion-implanted silicon solar cells are given. As a result of this study, a processing procedure was defined which can be used to produce ion-implanted solar cells with up to 15% efficiency. A review of a comprehensive test program performed on state-of-the-art commercial screen-printable metallizing inks as well as RCA-formulated materials is given. Data are presented on the critical areas of electrical conductivity, solderability, and adhesion of the films as-fired into silicon surfaces. A process for screen printing and infrared-lamp firing of silver inks for the front grid and back contact of 3-in.-diameter solar cells was developed, and performance data of these cells as a function of firing parameters and inks are given. The results of applying this process to ion-implanted solar cells are also presented. Process development and optimization studies for low-cost spray deposition of single-layer antireflection (AR) coatings are discussed. These studies included effects of spray deposition machine parameters, metallization bondability after coating, cell electrical performance as a function of AR coating type, thickness, and heat-treatment effects. The processing steps for a panel assembly process involving the lamination of a double-glass structure were developed. The procedures required to successfully laminate large panels are given. (WHK)

  19. Benchmarks and performance indicators: two tools for evaluating organizational results and continuous quality improvement efforts.

    Science.gov (United States)

    McKeon, T

    1996-04-01

    Benchmarks are tools that can be compared across companies and industries to measure process output. The key to benchmarking is understanding the composition of the benchmark and whether the benchmarks consist of homogeneous groupings. Performance measures expand the concept of benchmarking and cross organizational boundaries to include factors that are strategically important to organizational success. Incorporating performance measures into a balanced score card will provide a comprehensive tool to evaluate organizational results.

  20. Evaluation and comparison of clinical results of femoral fixation devices in arthroscopic anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Aydin, Deniz; Ozcan, Mert

    2016-03-01

    Several femoral fixation devices are available for hamstring tendon autograft in anterior cruciate ligament (ACL) reconstruction, but the best technique is debatable. We hypothesised that different suspensory femoral fixation techniques have no superiority over each other. The aim of this study was to evaluate and compare the clinical results of different suspensory femoral fixation devices in arthroscopic ACL reconstruction. This was a Level III, retrospective, comparative study. A total of 100 consecutive patients who underwent arthroscopic ACL reconstruction in a single institution with a mean follow-up time of 40 months (12-67 months) were divided into three groups according to femoral fixation devices as 'Endobutton' (n=34), 'Transfix' (n=35) and 'Aperfix' (n=31). The length of painful period after surgery, time to return to work and sporting activities, final range of motion, anterior drawer and Lachman tests, knee instability symptoms, International Knee Documentation Committee (IKDC) subjective knee evaluation score, Short Form 36 (SF-36) score, Lysholm knee score and Tegner point of the patients were evaluated and compared between groups. There were no significant differences between the groups. All techniques led to significant recovery in knee instability tests and symptoms. In this study, the clinical results of different suspensory femoral fixation techniques were found to be similar. We believe that different femoral fixation techniques have no effect on clinical results provided that the technique is correctly applied. The surgeon must choose a technique appropriate to his or her experience. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Follow the LEADER-Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results Trial.

    Science.gov (United States)

    Kalra, Sanjay

    2016-12-01

    This commentary analyzes the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial, which has reported the cardiovascular benefits of liraglutide. It places the results of this seminal trial in the context of the evolution of diabetes care, compares them with other recently published cardiovascular outcome trials, and suggests novel mechanisms to explain the benefits and properties of liraglutide. The editorial discusses the potential impact that LEADER will have on the prevention and management of diabetes and its vascular complications.

  2. A comprehensive performance evaluation on the prediction results of existing cooperative transcription factors identification algorithms.

    Science.gov (United States)

    Lai, Fu-Jou; Chang, Hong-Tsun; Huang, Yueh-Min; Wu, Wei-Sheng

    2014-01-01

    Eukaryotic transcriptional regulation is known to be highly connected through the networks of cooperative transcription factors (TFs). Measuring the cooperativity of TFs is helpful for understanding the biological relevance of these TFs in regulating genes. The recent advances in computational techniques led to various predictions of cooperative TF pairs in yeast. As each algorithm integrated different data resources and was developed based on different rationales, it possessed its own merit and claimed outperforming others. However, the claim was prone to subjectivity because each algorithm compared with only a few other algorithms and only used a small set of performance indices for comparison. This motivated us to propose a series of indices to objectively evaluate the prediction performance of existing algorithms. And based on the proposed performance indices, we conducted a comprehensive performance evaluation. We collected 14 sets of predicted cooperative TF pairs (PCTFPs) in yeast from 14 existing algorithms in the literature. Using the eight performance indices we adopted/proposed, the cooperativity of each PCTFP was measured and a ranking score according to the mean cooperativity of the set was given to each set of PCTFPs under evaluation for each performance index. It was seen that the ranking scores of a set of PCTFPs vary with different performance indices, implying that an algorithm used in predicting cooperative TF pairs is of strength somewhere but may be of weakness elsewhere. We finally made a comprehensive ranking for these 14 sets. The results showed that Wang J's study obtained the best performance evaluation on the prediction of cooperative TF pairs in yeast. In this study, we adopted/proposed eight performance indices to make a comprehensive performance evaluation on the prediction results of 14 existing cooperative TFs identification algorithms. Most importantly, these proposed indices can be easily applied to measure the performance of new

  3. Cervical Biopsy, Smear Evaluation and Comparison of Human Papilloma Virus Subtypes Result

    Directory of Open Access Journals (Sweden)

    Murat Arı

    2016-04-01

    Full Text Available Objective: The aim of this study was to investigate the relationship between human papilloma virüs (HPV types which was worked with polymerase chain reaction (PCR and immunohistochemistry methods and cvtology and biyopsy results. Materials and Methods: A total of 100 cases from hospital between 2010-2013 participitated in this study. Linear Array HPV genotyping test was worked with PCR, tissue biopsies was evaluated with light microscopy, HPV was detected with immunohistochemistry (IHK method and results were compared evaluating of conventional smear preparations according to Bethesda. Results: While 61 cases included high risk (61%, 39 cases included low risk HPV (39%. HPV types with high risk such as HPV16, HPV6, HPV11, HPV18, HPV31 respectively detected in 24, 19, 9, 7, 2 cases. HPV types with low risk such as HPV66 detected in 7 cases. HPV16 was observed epithelial cell abnormality such as 9 ASCUS, 3 LSIL,1 ASC-H, 1 AGUS in 14/24 ratio (58% and ILMAN was observed 10/24 ratio (42%. Between cytological diagnosis results and HPV types are significant relationship according to chi-square test (p=0.001. When the results of the biopsy tissue analyzed, 38 patients were diagnosed intraepithelial neoplasia and malignant, 62 cases were diagnosed inflammation and other benign featured. The relationship between tissue diagnosis and HPV types is significant according to chi-square test (p<0.001. HPV in tissue was positive in 44 cases. The relationship between HPV types and tissue HPV results are significant (p<0.001. The cytological tissue diagnosis of 19 patients with ASCUS has been reported as follows; 10 CIN1, 3 CIN2, 2 CIN3 and 4 inflammation. Negative and positive HPV results studied in tissue are not significant results with cytological diagnosis (p=0.02 and tissue diagnosis results (p=0.02. Conclusion: The important of HPV detection is obvious, but tissue changes as well as HPV detection are important. Thus combined use of testing, even in

  4. Modified glass ionomer and orthodontic band: An interim alternative for the treatment of molar incisor hypomineralization. A case report.

    Directory of Open Access Journals (Sweden)

    Carla Orellana

    2017-03-01

    Full Text Available Introduction: Molar incisor hypomineralization (MIH is a developmental condition resulting in defects in the enamel characterized by demarcated opacities mainly affecting first permanent molars and occasionally permanent incisors in 1 of every 6 children worldwide. Affected molars have greater susceptibility to post eruptive breakdown, extensive caries and, in severe cases, are difficult to restore. When the MIH-affected molar presents severe crown destruction, it is necessary to perform an intermediate restoration to preserve the remaining dental structure in order to maintain occlusion, proper hygiene and periodontal health. The case of an 11-year-old patient with severe MIH is reported. The patient had extensive crown destruction by caries in tooth 1.6 without clinical or radiographic signs of pulp pathology. After an initial preventive intervention, enamel without dentin support and carious dentin were removed from tooth 1.6. Subsequently, crown restoration was performed with resin-modified glass ionomer, followed by the cementation of an orthodontic band. After 18 months of follow-up, the patient reported no pain or discomfort. The restoration was preserved intact, maintaining occlusal functionality, pulp and gingival health. Conclusion: The interim treatment, cementing an orthodontic band over a tooth restored with glass ionomer seems to favor retention and compressive strength, keeping the MIH-affected molar asymptomatic for at least 18 months. Further studies evaluating this treatment option in similar clinical situations are recommended.

  5. Online smoking cessation program for Korean Americans: Randomized trial to test effects of incentives for program completion and interim surveys.

    Science.gov (United States)

    Moskowitz, Joel M; McDonnell, Diana D; Kazinets, Gene; Lee, Hyun-Ju

    2016-05-01

    Smoking is prevalent among Korean American men. Quitting is Winning, an Internet-based, cognitive-behavioral smoking cessation program, was developed using community-based participatory research principles. A randomized controlled trial was used to evaluate whether participants were more likely to complete the program and quit smoking at 6-months of follow-up with additional reinforcement. The main outcomes were the proportion of participants who completed the online program and the proportion who quit smoking for at least 30days, 26weeks after enrollment, among those randomized into the high-reinforcement (HR) condition compared with those in the low-reinforcement (LR) condition. The study achieved a final enrollment of 403 participants including 56 women. Program completion was greater for the HR as compared to the LR condition (17% vs. 10%, p=.035). There was no significant difference in 30-day smoking cessation (intent-to-treat [ITT]) between the HR and LR conditions (9% vs. 8%, ns). Smoking cessation was greater among program completers as compared to those who did not complete the program (28% vs. 5%, psurveys and financial incentives for interim survey completion and program completion significantly increased the likelihood of program completion. Moreover, program completers were significantly more likely to quit smoking. Although smoking cessation rates did not significantly differ between the HR and LR conditions, the results suggest that future studies should explore the efficacy of larger financial incentives for program completion (Clinical Trial #NCT02584127). Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Interim report of the SENTIS trial: cerebral perfusion augmentation via partial aortic occlusion in acute ischemic stroke.

    Science.gov (United States)

    Uflacker, R; Schönholz, C; Papamitisakis, N

    2008-12-01

    The aim of this paper was to present the interim results of the the Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke (SENTIS) trial. The SENTIS study is a phase III, multi-center randomized prospective study to evaluate cerebral perfusion augmentation with partial aortic occlusion in acute ischemic stroke. The trial was designed to compare conventional management of stroke patients with stroke patients treated by partial occlusion of the abdominal aorta by the NeuroFlo device. Follow up was at 24 hours and 90 days. Of the 100 patients enrolled, 53 were randomized to treatment and 47 to control. Six patients enrolled to treatment were found to have specific exclusion criteria and were excluded. Therefore, 97 validated patients, 47 treated patients and 47 control patients were included in the analysis. Adverse events were evenly distributed, among the two cohorts of patients with 16 patients or 34% in each group, including fatal and non-fatal adverse events. However, the mortality was significantly lower for the treated population (6.4%) versus the control population (14.9%), with more stroke progression (8.5%) and hemorrhagic transformation of the stroke area (4.3%) in the control population. The SENTIS trial was designed to test the hypothesis that the NeuroFlo system is safe to be used in humans and able to produce cerebral perfusion augmentation, based on imaging and neurological assessment at 24 hours and at 90 days. The preliminary data yielded by the interim analysis showed that the population enrolled in the trial was rather homogeneous regarding age, baseline NIHSS scores, and other risk factors, suggesting that the treated and control cohorts were similar. The analysis also showed that the adverse events were rather comparable between the two groups, suggesting the treatment procedure to be safe enough for continuation of the trial. The NeuroFlo system so far proved to be safe enough for clinical use and seems to be promising in improving

  7. Evaluation of the results from non-arthroplastic treatment (arthroscopy) for shoulder arthrosis☆

    Science.gov (United States)

    Miyazaki, Alberto Naoki; Fregoneze, Marcelo; da Silva, Luciana Andrade; do Val Sella, Guilherme; Garotti, José Eduardo Rosseto; Checchia, Sergio Luiz

    2015-01-01

    Objectives To evaluate the functional results from patients with arthrosis who underwent an arthroscopic procedure, in an attempt to correlate these results with the patients’ epidemiological profile, surgical technique used, possible complications and postoperative protocol. Methods Between 1998 and 2011, 31 patients (32 shoulders) with shoulder arthrosis underwent arthroscopic treatment performed by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology of Santa Casa de São Paulo. Primary or secondary cases of shoulder arthrosis under the age of 70 years, in which the rotator cuff was intact, were included. Furthermore, cases in which, despite an indication for an arthroplastic procedure, an attempt to perform an alternative procedure had been chosen, were also included. The following were evaluated: sex, age, dominance, comorbidities, length of time with complaint, associated lesions, etiology, previous treatment, operation performed, postoperative protocol and pre and postoperative active ranges of motion. The functional evaluation was conducted using the UCLA criteria, before and after the operation. The joint cartilage alterations were classified in accordance with Outerbridge and the arthrosis by means of Walch. Results There were statistically significant mean differences in the values for elevation, lateral rotation and medial rotation from before to after the operation (p < 0.001) and there was a tendency (p = 0.057) toward poor results with greater length of time with complaints before the surgery. The total gain in UCLA score did not have any statistically significant relationship with any of the other variables analyzed. Conclusion Arthroscopic treatment of glenohumeral arthrosis provided functional improvement of the glenohumeral joint, with significant gains in elevation and lateral and medial rotation, and improvements in function and pain. Greater length of time with complaints was a factor strongly suggestive of

  8. Evaluation of the results from non-arthroplastic treatment (arthroscopy for shoulder arthrosis

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2015-08-01

    Full Text Available ABSTRACTOBJECTIVES: To evaluate the functional results from patients with arthrosis who underwent an arthroscopic procedure, in an attempt to correlate these results with the patients' epidemiological profile, surgical technique used, possible complications and postoperative protocol. METHODS: Between 1998 and 2011, 31 patients (32 shoulders with shoulder arthrosis underwent arthroscopic treatment performed by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology of Santa Casa de São Paulo. Primary or secondary cases of shoulder arthrosis under the age of 70 years, in which the rotator cuff was intact, were included. Furthermore, cases in which, despite an indication for an arthroplastic procedure, an attempt to perform an alternative procedure had been chosen, were also included. The following were evaluated: sex, age, dominance, comorbidities, length of time with complaint, associated lesions, etiology, previous treatment, operation performed, postoperative protocol and pre and postoperative active ranges of motion. The functional evaluation was conducted using the UCLA criteria, before and after the operation. The joint cartilage alterations were classified in accordance with Outerbridge and the arthrosis by means of Walch. RESULTS: There were statistically significant mean differences in the values for elevation, lateral rotation and medial rotation from before to after the operation ( p< 0.001 and there was a tendency ( p= 0.057 toward poor results with greater length of time with complaints before the surgery. The total gain in UCLA score did not have any statistically significant relationship with any of the other variables analyzed. CONCLUSION: Arthroscopic treatment of glenohumeral arthrosis provided functional improvement of the glenohumeral joint, with significant gains in elevation and lateral and medial rotation, and improvements in function and pain. Greater length of time with complaints was a factor

  9. Breast conserving operation and radiation therapy in early breast cancer: interim analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Hee; Kim, Ok Bae; Kim, You Sah [College of Medicine, Keimyung Univ., Taegu (Korea, Republic of)

    2001-03-01

    To evaluate interim results in terms of failure, cosmetic results and survival after breast conserving operation and radiation therapy in early breast cancer. From January 1992 through December 1997, seventy two patients with early stage 0, I and II breast cancer were treated with conservative surgery plus radiotherapy at Keimyung University Dongsan Medical Center. Age distribution was 25 to 77 years old with median age of 43. Ac cording to TNM stage, five patients had stage 0, thirty three were stage I, twenty five were lIa, and nine were llb. Most patients underwent excision of all gross tumor and ipsilateral axillary dissection. Breast was irradiated through medial and lateral tangential fields of 6 MV photons to 50.4 Gy in 28 fractions over 5.5 weeks. We delivered a boost irradiation dose of 10 to 16 Gy in 1 to 2 weeks to excision site. Adjuvant chemotherapy was administered in forty one patients with CMF (cyclophosphamide, methotrexate, 5fluorouracil) regimens of 6 cycles concurrently or before radiation. Cosmetic results were assessed by questionnaire to patients grading of excellent, good, fair, poor. Follow-up periods were 22 to 91 months with median 40 months. Five year disease free survival rate (5YDFS) was 95.8%. According to stage, 5YDFS was 100%, 96.9%, 96% and 88.9% in stage 0, I, lIa and llb, respectively. Two patients had distant metastasis and one had local and distant failure. One patient with distant failure had bone and liver metastasis at 14 months after treatment and the other had lung and both supraclavicular metastasis at 21 months after treatment. Patient with local and distant failure had local recurrence on other quadrant in same breast and then salvaged with total mastectomy and chemotherapy but she died due to brain metastasis at 55 months. Complications were radiation pneumonitis in five patients (four patients of asymptomatic, one patient of symptomatic) and hand or arm edema(4 patients). Fifty nine patients answered our cosmetic

  10. Evaluating Behaviorally Oriented Aviation Maintenance Resource Management (MRM) Training and Programs: Methods, Results, and Conclusions

    Science.gov (United States)

    Taylor, James C.; Thomas, Robert L., III

    2003-01-01

    Assessment of the impact of Aviation Resource Management Programs on aviation culture and performance has compelled a considerable body of research (Taylor & Robertson, 1995; Taylor, 1998; Taylor & Patankar, 2001). In recent years new methods have been applied to the problem of maintenance error precipitated by factors such as the need for self-assessment of communication and trust. The present study - 2002 -- is an extension of that past work. This research project was designed as the conclusion of a larger effort to help understand, evaluate and validate the impact of Maintenance Resource Management (MRM) training programs, and other MRM interventions on participant attitudes, opinions, behaviors, and ultimately on enhanced safety performance. It includes research and development of evaluation methodology as well as examination of psychological constructs and correlates of maintainer performance. In particular, during 2002, three issues were addressed. First, the evaluation of two (independent & different) MRM programs for changing behaviors was undertaken. In one case we were able to further apply the approach to measuring written communication developed during 2001 (Taylor, 2002; Taylor & Thomas, 2003). Second, the MRM/TOQ surveys were made available for completion on the internet. The responses from these on-line surveys were automatically linked to a results calculator (like the one developed and described in Taylor, 2002) to aid industry users in analyzing and evaluating their local survey data on the internet. Third, the main trends and themes from our research about MRM programs over the past dozen years were reviewed.

  11. Airport surface moving map displays: OpEval-2 evaluation results and future plans

    Science.gov (United States)

    Livack, Garret; McDaniel, James I.; Battiste, Vernol

    2001-08-01

    The Federal Aviation Administration (FAA), in cooperation with the Cargo Airline Association (CAA) and three of its member airlines (Airborne Express, Federal Express, and United Parcel Service), have embarked upon an aggressive yet phased approach to introduce new Free Flight-enabling technologies into the U.S. National Airspace System (NAS). General aviation is also actively involved, represented primarily by the Aircraft Owners and Pilots Association (AOPA). These new technologies being evaluated include advanced cockpit avionics and a complimentary ground infrastructure. In support of this initiative, a series of operational evaluations (OpEvals) have been conducted or are planned. The OpEvals have evaluated in-flight as well as airport surface movement applications. Results from the second OpEval, conducted at Louisville, Kentucky in October 2000, indicated that runway incursions might be significantly reduced with the introduction of a cockpit-based moving map system derived from emerging technologies. An additional OpEval is planned to evaluate the utility of an integrated cockpit and airport surface architecture that provides enhanced pilot and controller awareness of airport surface operations. It is believed that the combination of such an airborne and a ground-based system best addresses many of the safety issues surrounding airport surface operations. Such a combined system would provide both flight crews and controllers with a common awareness, or shared picture of airport surface operations.

  12. Results-Oriented Evaluations: Their Uses, Their Limits and How They are Driving Implementers‘ Coping Strategies

    Directory of Open Access Journals (Sweden)

    Michel Leroy

    2015-01-01

    Full Text Available While the use of monitoring and evaluation (M&E by media development implementers is well documented, organizations’ coping strategies to adapt to new environments in media and development still remain a relatively unexplored area. The article aims at showing how the theoretical lessons learnt by the industry have been put into practice and how a successful change can be driven within an organization using outside experts. A results-oriented culture of performance and service has been enforced since the 1990s in the EU. Evaluation systems have been a powerful catalyst in driving the transition from media support to media development and in making the latter more independent from broadcasters and donors. In recent years, changes in media assistance procedures and aims have profoundly modified the traditional landscape. This article will not question these changes, their origin and motivations. It will focus on implementers’ coping strategies to adapt (or not to these new procedures and aims and how results-oriented evaluations can drive the shift from outputs to outcomes in a changing media development sector. Can capitalizing on experience be considered a learning process that prepares for change and improves the design and implementation of projects? To what extent can it help to empower the operator as an organization? Referring to various concrete case studies from British, French and German media assistance, the article will focus on virtuous change – the circumstances that encourage structures, as well as donors who fund them, to better define and operationalize their strategies.

  13. Evaluation of the functional results after rotator cuff arthroscopic repair with the suture bridge technique

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    Full Text Available ABSTRACT OBJECTIVE: To evaluate the results of arthroscopic treatment of large and extensive rotator cuff injuries (RCI that involved the supra and infraspinatus muscles using the suture bridge (SB technique. METHODS: Between July 2010 and November 2014, 37 patients with RCI who were treated with SB technique were evaluated. The study included all patients with a minimum follow-up of 12 months who underwent primary surgery of the shoulder. Twenty-four patients were male and 13 were female. The mean age was 60 years (45-75. The dominant side was affected in 32 cases. The most common cause of injury was trauma (18 cases. The mean preoperative motion was 123°, 58°, T11. Through magnetic resonance imaging, 36 fatty degenerations were classified according to Goutallier. Patients underwent rotator cuff repair with SB technique, which consists of using a medial row anchor with two Corkscrew(r fibertape(r or fiberwire(r at the articular margin, associated with lateral fixation without stitch using PushLocks(r or SwiveLocks(r. RESULTS: The mean age was 60 years and mean fatty degeneration was 2.6. The mean range of motion (following the AAOS in the postoperative evaluation was 148° of forward elevation, 55° in lateral rotation and medial rotation in T9. Using the criteria of the University of California at Los Angeles (UCLA, 35 (94% patients had excellent and good results; one (2.7%, fair; and one (2.7%, poor. CONCLUSION: Arthroscopic repair of a large and extensive RCI using SB technique had good and excellent results in 94% of the patients.

  14. Explicit feedback to enhance the effect of an interim assessment: a cross-over study on learning effect and gender difference

    NARCIS (Netherlands)

    Olde Bekkink, M.; Donders, R.; Muijen, G.N. van; Waal, R.M. de; Ruiter, D.J.

    2012-01-01

    In a previous study we demonstrated by a prospective controlled design that an interim assessment during an ongoing small group work (SGW) session resulted in a higher score in the course examination. As this reflects the so-called testing effect, which is supposed to be enhanced by feedback, we

  15. How you evaluate treatment results in low back pain patients depends on who the patient is

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    2008-01-01

    How you evaluate treatment results in low back pain patients depends on who the patient is Lauridsen, HH 1*, Hartvigsen, J1,2, Manniche, C1,3, Korsholm, L1,4, Grunnet-Nilsson, N1 1.    Clinical Locomotion Science, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark...... pain subscales of the SF36, the Low Back Pain Rating Scale (LBPRS) and a numerical rating scale for pain (0-10) were completed by 191 patients from the primary and secondary sectors of the Danish health care system. Clinical change was estimated using a 7-point transition question and a numeric rating...... of an evaluative instrument in back pain patients is complicated because of lack of head-to-head comparisons of clinimetric properties of the various instruments. In addition, little is known about instrument behaviour in clinical subgroups. The objective of this study was to concurrently compare responsiveness...

  16. The delay effect on outcome evaluation: results from an Event-related Potential study

    Directory of Open Access Journals (Sweden)

    Chen eQu

    2013-11-01

    Full Text Available Behavioral studies demonstrate that the timing of receiving gains or losses affects decision-making, a phenomenon known as temporal discounting, as participants are inclined to prefer immediate rewards over delayed ones and vice versa for losses. The present study used the event-related potential (ERP technique with a simple gambling task to investigate how delayed rewards and losses affected the brain activity in outcome evaluations made by 20 young adults. Statistical analysis revealed a larger feedback related negativity (FRN effect between loss and gain following immediate outcomes than following future outcomes. In addition, delay impacted FRN only in gain conditions, with delayed winning eliciting a more negative FRN than immediatewinning. These results suggest that temporal discounting and sign effect could be encoded in the FRN in the early stage of outcome evaluation.

  17. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: Second Results Report and Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2011-10-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. This is the second results report for the AT fuel cell bus since it was placed in service, and it focuses on the newest data analysis and lessons learned since the previous report. The appendices, referenced in the main report, provide the full background for the evaluation. They will be updated as new information is collected but will contain the original background material from the first report.

  18. Method of preparing nuclear wastes for tansportation and interim storage

    Science.gov (United States)

    Bandyopadhyay, Gautam; Galvin, Thomas M.

    1984-01-01

    Nuclear waste is formed into a substantially water-insoluble solid for temporary storage and transportation by mixing the calcined waste with at least 10 weight percent powdered anhydrous sodium silicate to form a mixture and subjecting the mixture to a high humidity environment for a period of time sufficient to form cementitious bonds by chemical reaction. The method is suitable for preparing an interim waste form from dried high level radioactive wastes.

  19. Interim Sanitary Landfill Groundwater Monitoring Report. 1997 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    Eight wells of the LFW series monitor groundwater quality in the Steed Pond Aquifer (Water Table) beneath the Interim Sanitary Landfill at the Savannah River Site (SRS). These wells are sampled semiannually to comply with the South Carolina Department of Health and Environmental Control Modified Municipal Solid Waste Permit 025500-1120 (formerly dWP-087A) and as part of the SRS Groundwater Monitoring Program.

  20. Evaluation Criteria and Results of Full Scale Testing of Bridge Abutment Made from Reinforced Soil

    Science.gov (United States)

    Hildebrand, Maciej; Rybak, Jarosław

    2017-10-01

    Structures made of reinforced soil can be evaluated for their safety based on a load testing. Measurement results are essentially evaluated by displacements of surcharge (mainly in vertical direction) and facing elements (mainly in horizontal direction). Displacements are within several tenths to several millimetres and they can be taken by common geodetic equipment. Due to slow soil consolidation (progress of displacements) under constant load, observations should be made over several days or even weeks or months. A standard procedure of heating of geotextiles, used in laboratory conditions to simulate long term behaviour cannot be used in a natural scale. When the load is removed, the soil unloading occurs. Both the progress of displacements and soil unloading after unloading of the structure are the key presumptions for evaluating its safety (stability). Assessment of measuring results must be preceded by assuming even the simplest model of the structure, so as it could be possible to estimate the expected displacements under controlled load. In view of clearly random nature of soil parameters of retaining structure composed of reinforced soil and due to specific erection technology of reinforced soil structure, the assessment of its condition is largely based on expert’s judgment. It is an essential and difficult task to interpret very small displacements which are often enough disturbed by numerous factors like temperature, insolation, precipitation, vehicles, etc. In the presented paper, the authors tried to establish and juxtapose some criteria for a load test of a bridge abutment and evaluate their suitability for decision making. Final remarks are based on authors experience from a real full scale load test.

  1. Efficiency of Injection Therapy for Stress Incontinence: a Retrospective Evaluation of 8 Years Results

    Directory of Open Access Journals (Sweden)

    Kemal Ener

    2012-09-01

    Full Text Available Aim: To evaluate the long term affectivity of transurethral Calcium Hydroxylapatite (CaHA; Coaptite® injection therapy and the predictive importance of Body Mass Index (BMI, menopausal status and previous anti-incontinence surgery in selected female patients with stress urinary incontinence (SUI. Material and Method: Forty-five female patients with SUI, and having high risks for general anesthesia, received transurethal injection therapy, were evaluated retrospectively. First month, 12th month, and 8th year of post-injection period were evaluated in terms of International Consultatiton on Incontinence Questionnaire Short Form (ICIQ-SF, Quality of Life (QoL score, and pad test. Results: While the pad test of 1st and 12th months’ showed statistically significance, the pad test of last visit was found insignificant, when compared with pre-injection term. Through the evaluations of questionnaire forms similar to the pad test, it was observed that the post- injection scores showed statistically significance. However, unlike to the pad test, for each of both questionnaires, statistically significant differences were detected at the last examination’s scores, as well. When we examined the success of the transurethral injection treatment according to menopausal status, BMI, and previous anti-incontinence surgery, it was observed that QoL and ICIQ-SF score %variation, and 24 hr pad test values did not show any statistically significant differences at long term control, compared with the pre-injection term. Discussion: Transurethral injection is a cheap, easily performed and affective method for selected patients with SUI and BMI, previous anti-incontinence surgery, and menopausal status do not affect transurethral injection results at long term.

  2. Evaluation and perceived results of moral case deliberation: A mixed methods study.

    Science.gov (United States)

    Janssens, Rien M J P A; van Zadelhoff, Ezra; van Loo, Ger; Widdershoven, Guy A M; Molewijk, Bert A C

    2015-12-01

    Moral case deliberation is increasingly becoming part of various Dutch healthcare organizations. Although some evaluation studies of moral case deliberation have been carried out, research into the results of moral case deliberation within aged care is scarce. How did participants evaluate moral case deliberation? What has moral case deliberation brought to them? What has moral case deliberation contributed to care practice? Should moral case deliberation be further implemented and, if so, how? Quantitative analysis of a questionnaire study among participants of moral case deliberation, both caregivers and team leaders. Qualitative analysis of written answers to open questions, interview study and focus group meetings among caregivers and team leaders. Caregivers and team leaders in a large organization for aged care in the Netherlands. A total of 61 moral case deliberation sessions, carried out on 16 care locations belonging to the organization, were evaluated and perceived results were assessed. Participants gave informed consent and anonymity was guaranteed. In the Netherlands, the law does not prescribe independent ethical review by an Institutional Review Board for this kind of research among healthcare professionals. Moral case deliberation was evaluated positively by the participants. Content and atmosphere of moral case deliberation received high scores, while organizational issues regarding the moral case deliberation sessions scored lower and merit further attention. Respondents indicated that moral case deliberation has the potential to contribute to care practice as relationships among team members improve, more openness is experienced and more understanding for different perspectives is fostered. If moral case deliberation is to be successfully implemented, top-down approaches should go hand in hand with bottom-up approaches. The relevance of moral case deliberation for care practice received wide acknowledgement from the respondents. It can contribute

  3. Interim data report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Vahlund, Fredrik [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2004-08-01

    This document is the interim data report in the project SR-Can. The purpose of the data report is to present input data, with uncertainty estimates, for the SR-Can assessment calculations. Besides input data, the report also describes the standardised procedures used when deriving the input data and the corresponding uncertainty estimates. However, in the present interim version of the report (written in the initial stage of the project when site characterisation has yet not been completed) the standardised procedures have not been possible to apply for most of the data and, in order to present a compilation of the data used in the assessment, much of the input data is presented without following the standardised procedures. This will however be changed for the final version of the SR-Can data report, in order to show the methodology that will be used in the final version one example of how input data will be presented is included (migration data for buffer) . The recommended input data for the assessment calculations are, for the interim version, mainly based on SR 97 Beberg data, these are merely presented without any background or uncertainty discussion (this is presented in the SR 97 data report)

  4. Evaluating the Potential of NASA's Earth Science Research Results for Improving Future Operational Systems

    Science.gov (United States)

    Frederick, M. E.; Cox, E. L.; Friedl, L. A.

    2006-12-01

    NASA's Earth Science Theme is charged with implementing NASA Strategic Goal 3A to "study Earth from space to advance scientific understanding and meet societal needs." In the course of meeting this objective, NASA produces research results, such as scientific observatories, research models, advanced sensor and space system technology, data active archives and interoperability technology, high performance computing systems, and knowledge products. These research results have the potential to serve society beyond their intended purpose of answering pressing Earth system science questions. NASA's Applied Sciences Program systematically evaluates the potential of the portfolio of research results to serve society by conducting projects in partnership with regional/national scale operational partners with the statutory responsibility to inform decision makers. These projects address NASA's National Applications and the societal benefit areas under the IEOS and GEOSS. Prototyping methods are used in two ways in NASA's Applied Sciences Program. The first is part of the National Applications program element, referred to as Integrated Systems Solutions (ISS) projects. The approach for these projects is to use high fidelity prototypes to benchmark the assimilation of NASA research results into our partners' decision support systems. The outcome from ISS projects is a prototype system that has been rigorously tested with the partner to understand the scientific uncertainty and improved value of their modified system. In many cases, these completed prototypes are adopted or adapted for use by the operational partners. The second falls under the Crosscutting Solutions program element, referred to as Rapid Prototyping (RP) experiments. The approach for RP experiments is to use low fidelity prototypes that are low cost and quickly produced to evaluate the potential of the breadth of NASA research results to serve society. The outcome from the set of RP experiments is an

  5. Evaluation of the results from partial arthroplasty for treating shoulder osteoarthrosis

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2013-04-01

    Full Text Available OBJECTIVE: In this study we aim at statistically evaluating the results of the surgical treatment of the osteoarthrosis of the shoulder (OAS with partial shoulder arthroplasty (PSA and at correlating them with the several variables involved. METHODS: In this study we evaluated 36 shoulders of 31 patients with OAS who underwent treatment with PSA in the Grupo de Ombro e Cotovelo (Group of Shoulders and Elbows of the Department of Traumatology and Orthopedics of the Faculdade de Ciências Médicas da Santa Casa de São Paulo - Pavillion Fernandinho Simonsen between January, 1989 and November, 2010. Patients who underwent PSA and who had a post-operative follow-up of at least 12 months were included in the study. RESULTS: After the surgery the range of elevation, external rotation, internal rotation and the UCLA scale improved (with average differences of 35º, 27º, 4ºand 17 points, respectively, with a significant level of 5% (p < 0.05. For the same level of significance, the relation between a satisfactory UCLA and two variables was found: patients with maximum age of 60 years old at the moment of the surgery and patients that underwent tenotomy of the long head of biceps. CONCLUSION: Patients under 60 who underwent surgery and patients who underwent tenotomy of the long head of biceps achieved better results.

  6. Evaluation of NACA0012 airfoil test results in the NAL two-dimensional transonic wind tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Sudani, N.; Kanda, H.; Sato, M.; Miwa, H.; Matsuno, K.; Takanashi, S. [National Aerospace Laboratory, Tokyo (Japan)

    1991-05-01

    This paper describes a method with correction for the sidewall effects and the evaluation of the air foil test in the two-dimensional transonic wind tunnel. Surface pressure and drag measurements on the NACA0012 airfoil were conducted in the two-dimensional wind tunnel of National Aerospace Laboratory (NAL,Japan). Using a comparison with other wind tunnel data, the wall interference effects are discussed, especially those from the sidewall. The results suggest that the Mach number of the actual flow around the airfoil is lower than the setting Mach number. The Mach number correction for the sidewall boundary-layer effects based on the similarity rule was applied to the present measurements, thereby showing that the shock positions the pressure distributions, and the minimum drag coefficients are in good agreement with both other wind tunnel results and the Navier-Stokes calculation. It is shown that this correction method and the evaluation indicates satisfactory transonic airfoil test results in the NAL two-dimensional transonic wind tunnel. 10 refs., 11 figs., 1 tab.

  7. Evaluation of the functional results after rotator cuff arthroscopic repair with the suture bridge technique.

    Science.gov (United States)

    Miyazaki, Alberto Naoki; Santos, Pedro Doneux; Sella, Guilherme do Val; Checchia, Caio Santos; Salata, Thiago Roncoletta; Checchia, Sergio Luiz

    2017-01-01

    To evaluate the results of arthroscopic treatment of large and extensive rotator cuff injuries (RCI) that involved the supra and infraspinatus muscles using the suture bridge (SB) technique. Between July 2010 and November 2014, 37 patients with RCI who were treated with SB technique were evaluated. The study included all patients with a minimum follow-up of 12 months who underwent primary surgery of the shoulder. Twenty-four patients were male and 13 were female. The mean age was 60 years (45-75). The dominant side was affected in 32 cases. The most common cause of injury was trauma (18 cases). The mean preoperative motion was 123°, 58°, T11. Through magnetic resonance imaging, 36 fatty degenerations were classified according to Goutallier. Patients underwent rotator cuff repair with SB technique, which consists of using a medial row anchor with two Corkscrew(®) fibertape(®) or fiberwire(®) at the articular margin, associated with lateral fixation without stitch using PushLocks(®) or SwiveLocks(®). The mean age was 60 years and mean fatty degeneration was 2.6. The mean range of motion (following the AAOS) in the postoperative evaluation was 148° of forward elevation, 55° in lateral rotation and medial rotation in T9. Using the criteria of the University of California at Los Angeles (UCLA), 35 (94%) patients had excellent and good results; one (2.7%), fair; and one (2.7%), poor. Arthroscopic repair of a large and extensive RCI using SB technique had good and excellent results in 94% of the patients.

  8. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: First Results Report

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2011-03-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. This report provides the early data results and implementation experience of the AT fuel cell bus since it was placed in service.

  9. Allowable peak heat-up cladding temperature for spent fuel integrity during interim-dry storage

    Directory of Open Access Journals (Sweden)

    Ki-Nam Jang

    2017-12-01

    Full Text Available To investigate allowable peak cladding temperature and hoop stress for maintenance of cladding integrity during interim-dry storage and subsequent transport, zirconium alloy cladding tubes were hydrogen-charged to generate 250 ppm and 500 ppm hydrogen contents, simulating spent nuclear fuel degradation. The hydrogen-charged specimens were heated to four peak temperatures of 250°C, 300°C, 350°C, and 400°C, and then cooled to room temperature at cooling rates of 0.3 °C/min under three tensile hoop stresses of 80 MPa, 100 MPa, and 120 MPa. The cool-down specimens showed that high peak heat-up temperature led to lower hydrogen content and that larger tensile hoop stress generated larger radial hydride fraction and consequently lower plastic elongation. Based on these out-of-pile cladding tube test results only, it may be said that peak cladding temperature should be limited to a level < 250°C, regardless of the cladding hoop stress, to ensure cladding integrity during interim-dry storage and subsequent transport.

  10. Maywood Interim Storage Site environmental report for calendar year 1989, Maywood, New Jersey

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-01

    The environmental monitoring program, which began in 1984, was continued in 1989 at the Maywood Interim Storage Site (MISS), a US Department of Energy (DOE) facility located in the Borough of Maywood and the Township of Rochelle Park, New Jersey. MISS is currently used for storage of soils contaminated with low-level radioactivity. MISS is part of the Formerly Utilized Sites Remedial Action Program (FUSRAP), a DOE program to identify and decontaminate or otherwise control sites where residual radioactive materials are present. The monitoring program at MISS measures thoron and radon concentrations in air; external gamma radiation levels; and thorium, uranium, and radium concentrations in surface water, groundwater, and sediment. Additionally, several nonradiological parameters are measured in groundwater. The radiation dose was calculated for a hypothetical maximally exposed individual to verify that the site is in compliance with the DOE radiation protection standard (100 mrem/yr) and to assess its potential effects on public health. This report presents the results of the environmental monitoring program conducted at the US Department of Energy's (DOE) Maywood Interim Storage Site (MISS) during calendar year 1989. Environmental monitoring began at MISS in 1984. 19 refs., 23 figs., 14 tabs.

  11. Report on achievements in fiscal 1998. Development of an interim processing technology to re-commercialize mixed waste plastics; 1998 nendo kongo haipura saishohinka no tame no chukan shori system gijutsu no kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-01

    The container and package recycling law is fully enforced starting fiscal 2000. Recycling obligation is placed also on plastic containers and packages discharged from households, excepting PET bottles for beverages and soy sauce. Therefore, it is required to establish an interim processing technology to process these materials into shapes easy for re-utilization and transportation, that is a technology to manufacture granules with adequate diameters. The purpose of this research is to develop the interim processing system technology. Design, fabrication and installation were performed on an interim processing system plant (a mixed waste plastic granule manufacturing facility) that can process annually waste plastics of 3,000 tons (0.5 t/h). The plant consists of the following four pieces of equipment: (1) a pulverizer, (2) a PVC sorting device, (3) a granulating device, and (4) a sizer. After the installed interim processing system demonstration plant has been trially operated and adjusted by each device, the whole plant was given the trial operation and adjustment to have verified that all the devices function normally. In addition, in order to evaluate economy of the waste plastics interim processing, the processing cost was calculated and the economic performance was evaluated preliminarily by using the rated electric power setting and trial operation data of each device. (NEDO)

  12. Quality of courses evaluated by 'predictions' rather than opinions: Fewer respondents needed for similar results.

    Science.gov (United States)

    Cohen-Schotanus, Janke; Schönrock-Adema, Johanna; Schmidt, Henk G

    2010-01-01

    A well-known problem with student surveys is a too low response rate. Experiences with predicting electoral outcomes, which required much smaller sample sizes, inspired us to adopt a similar approach to course evaluation. We expected that having respondents estimate the average opinions of their peers required fewer respondents for comparable outcomes than giving own opinions. Two course evaluation studies were performed among successive first-year medical students (N = 380 and 450, respectively). Study 1: Half the cohort gave opinions on nine questions, while the other half predicted the average outcomes. A prize was offered for the three best predictions (motivational remedy). Study 2: Half the cohort gave opinions, a quarter made predictions without a prize and a quarter made predictions with previous year's results as prior knowledge (cognitive remedy). The numbers of respondents required for stable outcomes were determined following an iterative process. Differences between numbers of respondents required and between average scores were analysed with ANOVA. In both studies, the prediction conditions required significantly fewer respondents (p < 0.001) for comparable outcomes. The informed prediction condition required the fewest respondents (N < 20). Problems with response rates can be reduced by asking respondents to predict evaluation outcomes rather than giving opinions.

  13. Ultrasound functional evaluation of fetuses with myelomeningocele: study of the interpretation of results.

    Science.gov (United States)

    Maroto, A; Illescas, T; Meléndez, M; Arévalo, S; Rodó, C; Peiró, J L; Belfort, M; Cuxart, A; Carreras, E

    2017-10-01

    To assess the reliability of the interpretation of a new technique for the ultrasound evaluation of the level of neurological lesion in fetuses with myelomeningocele. Observational study including myelomeningocele fetuses, referred to our center for the sonographic assessment of the fetal lower-limb movements, made and recorded by an expert in Maternal-fetal medicine and a specialist in Rehabilitation. Two observers, with different levels of expertise and blinded to each other's results, interpreted each recorded scan two different times. The agreement for the segmental levels assigned between the observers and the gold standard, the inter-observer and intra-observer reproducibility were tested using the weighed Kappa (wκ) index. Twenty-eight scans were recorded and evaluated. The agreement between the observers and the gold standard remained constant for the expert observer (wκ = 0.82) and increased (wκ = 0.66-wκ = 0.72) for the other one. The inter-observer and the intra-observer variability for the expert observer were wκ = 0.72 and wκ = 0.94, respectively. The agreement for the prenatal evaluation of the segmental neurological level was excellent, after a short training period, for observers with different degrees of expertise. The interpretation of this technique is reproducible enough and this supports its value for the prediction of postnatal motor function in myelomeningocele fetuses.

  14. Central washout sign in computer-aided evaluation of breast MRI: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Eun Sook (Dept. of Radiology, Samsung Medical Center, Sungkyunkwan Univ. School of Medicine, Seoul (Korea, Republic of)), e-mail: mathilda0330@gmail.com; Choi, Hye Young (Dept. of Radiology, Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of)); Lee, Byung Hee (Dept. of Radiology, Korea Cancer Centre Hospital, Seoul (Korea, Republic of)); Noh, Woo-Chul (Dept. of Surgery, Korea Cancer Centre Hospital, Seoul (Korea, Republic of)); Kim, Rock Bum (Dept. of Preventive Medicine, Gyeongsang National Univ., Jinju (Korea, Republic of))

    2011-04-15

    Background: Although computer-aided evaluation (CAE) programs were introduced to help differentiate benign tumors from malignant ones, the set of CAE-measured parameters that best predict malignancy have not yet been established. Purpose: To assess the value of the central washout sign on CAE color overlay images of breast MRI. Material and Methods: We evaluated the frequency of the central washout sign using CAE. The central washout sign was determined so that thin, rim-like, persistent kinetics were seen in the periphery of the tumor. Then, sequentially, plateau and washout kinetics appeared. Two additional CAE-delayed kinetic variables were compared with the central washout sign for assessment of diagnostic utility: the predominant enhancement type (washout, plateau, or persistent) and the most suspicious enhancement type (any washout > any plateau > any persistent kinetics). Results: One hundred and forty-nine pathologically proven breast lesions (130 malignant, 19 benign) were evaluated. A central washout sign was associated with 87% of malignant lesions but only 11% of benign lesions. Significant differences were found when delayed-phase kinetics were categorized by the most suspicious enhancement type (P< 0.001) and the presence of the central washout sign (P< 0.001). Under the criteria of the most suspicious kinetics, 68% of benign lesions were assigned as plateau or washout pattern. Conclusion: The central washout sign is a reliable indicator of malignancy on CAE color overlay images of breast MRI

  15. EVALUATION OF ECOLOGICAL EFFICIENCY RESULTING FROM THE APPLICATION OF MODERN BUSES IN URBAN COMMUNICATIONS

    Directory of Open Access Journals (Sweden)

    Halina Marczak

    2017-09-01

    Full Text Available The use of modern vehicles may contribute to limiting the adverse impact of urban transport on the environment. Evaluation of options for choosing new means of transport in terms of economic and ecological benefits allows for the identification of the most advantageous variants. The solution is to consider replacing a bus compliant with a Euro III norm (base variant with a bus compliant with Euro VI (option 1 or with an electric bus (option 2. The evaluation of the solutions was based on the calculated parameters: a monetary value reflecting the energy cost of the analyzed buses and the ecological effect of the reduced emissions from the Euro VI bus and the electric bus compared with the Euro III vehicle. The ecological effect resulting from the use of the electric bus was determined taking into account emissions from fossil fuels (coal, natural gas and biomass. The method of cost analysis was used to evaluate the solution of replacing older buses with new ones (with different types of propulsion. It is based on calculating the unit cost of achieving the ecological effect of the solution.

  16. Process evaluation results of a cluster randomised controlled childhood obesity prevention trial: the WAVES study

    Directory of Open Access Journals (Sweden)

    T. L. Griffin

    2017-08-01

    Full Text Available Abstract Background Increasing prevalence of childhood obesity and its related consequences emphasises the importance of developing and evaluating interventions aimed at prevention. The importance of process evaluation in health intervention research is increasingly recognised, assessing implementation and participant response, and how these may relate to intervention success or failure. A comprehensive process evaluation was designed and undertaken for the West Midlands ActiVe lifestyle and healthy Eating in School children (WAVES study that tested the effectiveness of an obesity prevention programme for children aged 6-7 years, delivered in 24 UK schools. The four intervention components were: additional daily school-time physical activity (PA; cooking workshops for children and parents; Villa Vitality (VV, a 6-week healthy lifestyle promotion programme run by a local football club; and signposting to local PA opportunities. Methods Data relating to six dimensions (Fidelity, Reach, Recruitment, Quality, Participant Responsiveness, Context were collected via questionnaires, logbooks, direct observations, focus groups and interviews. Multiple data collection methods allowed for data triangulation and validation of methods, comparing research observations with teacher records. The 6-stage WAVES study model ((i Data collection, (ii Collation, (iii Tabulation, (iv Score allocation and discussion, (v Consultation, (vi Final score allocation was developed to guide the collection, assimilation and analysis of process evaluation data. Two researchers independently allocated school scores on a 5-point Likert scale for each process evaluation dimension. Researchers then discussed school score allocations and reached a consensus. Schools were ranked by total score, and grouped to reflect low, medium or high intervention implementation. Results The intervention was predominantly well-implemented and well-received by teachers, parents and children. The PA

  17. A prospective evaluation of zirconia posterior fixed dental prostheses: three-year clinical results.

    Science.gov (United States)

    Peláez, Jesus; Cogolludo, Pablo G; Serrano, Benjamin; Lozano, Jose F L; Suárez, Maria J

    2012-06-01

    Although the favorable mechanical properties of zirconium oxide-based ceramics have increased the acceptance of fixed dental prostheses for use in the posterior regions of the mouth in recent years, there are few clinical studies documenting the longevity of these restorations. Furthermore, certain complications must be resolved before the material is used more extensively. The purpose of this randomized prospective study was to evaluate the clinical performance of zirconia (Lava) 3-unit posterior fixed dental prostheses. Twenty 3-unit fixed dental prostheses were placed in 17 participants to replace a second premolar or a first molar. Eleven were placed in the maxilla and 9 in the mandible. All abutment teeth were prepared with a chamfer finish line of 0.8 to 1 mm, and frameworks were prepared with the Lava system. Restorations were cemented with a resin cement. Two calibrated examiners independently evaluated the fixed dental prostheses 1 week (baseline) and 1, 2, and 3 years after placement with the California Dental Association quality evaluation system. The periodontal parameters: the gingival index, plaque index, margin index, and the probing depths of abutment teeth and contralateral teeth were assessed. Data were analyzed by using descriptive statistics and the Wilcoxon signed-rank test (α=.05). All fixed dental prostheses were rated satisfactory after 3 years, and no fracture of the framework was observed during the observation period. One fixed dental prostheses was lost because of a biological complication at the 3-year examination, and a small degree of chipping of the veneering ceramic was observed in 2 participants. No significant differences among the periodontal parameters of the test and control teeth were observed except for the margin index. The results of a 3-year evaluation suggest that posterior zirconia 3-unit fixed dental prostheses are a reliable treatment. Copyright © 2012 The Editorial Council of the Journal of Prosthetic Dentistry

  18. Developing a conceptual approach for regional climate model evaluation: initial results

    Science.gov (United States)

    di Luca, A.; de Elía, R.; Laprise, R.

    2009-12-01

    Regional Climate Models (RCMs) are tools now commonly used for producing high-resolution simulations of present climate and of future climate change projections. One of the most elusive issues in regional climate modeling is model evaluation, not only due to a sparseness of climate observations but also because of the intrinsic complexities of this task. One important difficulty in model evaluation is that models may sometimes produce the right results for the wrong reason. For example, an RCM may properly simulate the daily average temperature over a given region, but this maybe the consequence of compensating errors. In the case of an RCM that produces excessive cloudiness, cooler days (i.e., negative bias) and warmer nights (i.e., positive bias) than observed are usually the net effects, but both bias compensate to produce a daily average temperature close to the observed one. The question that we would like to investigate in this research is directly linked to this issue: under what conditions are we to accept model results as good? The starting point in order to tackle this challenging issue is to suggest a definition of “model goodness". Following ideas borrowed from epistemology and logic, we may define that a model result is good, if it remains good "under all possible refinements". In this context, the term “refinement” can be understood as an increasingly detailed inspection of model results that may help to unmask good results brought by a compensation of errors. The specifics of how a refinement may work will be explained by describing the particular case of time-scale refinement. Consider a time series of hourly precipitation in a given region. The evaluation of the model may start, and usually does, by assessing the simulation of seasonal or monthly mean values against observed data (e.g., the annual cycle). Once these values have proven to be relatively well simulated, the evaluation can go on with the analysis of simulated precipitation

  19. Lecturers’ Commitment And Students’ Academic Achievement: Case Study From Existing Teaching Evaluation Result (TER

    Directory of Open Access Journals (Sweden)

    Tengku Noorainun Tengku Shahdan

    2012-09-01

    Full Text Available This study reported herein is the used of TER as the basis to ascertain if the commitment of the lecturers can lead to academic excellence of the students.  The TER is comprised of questionnaires in which the foundation students are the respondents (N=433 in assessing the courses as well as the lecturers.  The performances of the students in the form of final exam grades are also used. The respondents were comprised of 85% Indian, 10% Malay and 5% Chinese.  There are more than 30% of the students who have obtained a grade of A- and better, the TER was < 80%.  Due to the limitation and the unavailability of matching each student to their evaluation towards the lecturers, the results presented above is weakly conclusive. It is recommended that future research in similar areas to incorporate the matching of students be made with the lecturers to obtain reliable and conclusive result.

  20. ExoMars 2016 EDM SM Mechanical Test Campaign Engineering Results Evaluation

    Science.gov (United States)

    Luison, Dario; Tenore, Amedeo Giancarlo

    2014-06-01

    This paper describes the analytical engineering activities done in the frame of ExoMars Descent Module (EDM) Structural Model (SM) Mechanical Test Campaign performed in ESTEC (for Sinusoidal Test) and in Thales Alenia Space Turin (Italy) laboratories (for Static Test) in the period from February and July 2013.The main results of Sine and Static Tests are described, as well as the updating of the Mathematical Model based on the results of the Base Excitation Vibration Modal Parameters Extraction. The engineering test evaluation activity was concentrated in particular on the simulation of the failure occurred during the sine test. This failure represented a serious issues never encountered in previous tests. Despite the gravity of the phenomenon, in a short time, the engineering was able to prove the structural integrity and to conclude successfully the test.

  1. Evaluation of Variability in Resilient Modulus Test Results (ASTM D4123)

    Science.gov (United States)

    1989-10-01

    Samples of asphalt mixture were evaluated in the laboratory under various conditions to evaluate the repeatability of the resilient modulus test and to evaluate the effect of stress on the measured resilient modulus. Some of the samples were prepared...

  2. Evaluation of the results from surgical treatment of the terrible triad of the elbow,

    Directory of Open Access Journals (Sweden)

    Alberto Naoki Miyazaki

    2014-06-01

    Full Text Available OBJECTIVE: to evaluate the results from surgical treatment of the terrible triad of the elbow (fracture of the radial head, fracture of the coronoid process and elbow dislocation and its complications.METHODS: between August 2002 and August 2010, 15 patients (15 elbows with the terrible triad were treated by the Shoulder and Elbow Group of the Department of Orthopedics and Traumatology, School of Medical Sciences, Santa Casa de São Paulo. Nine (60% were male and six (40% were female; their ages ranged from 21 to 66 years, with a mean of 41 years. With the exception of one case that underwent arthroscopic surgery, all the patients underwent open surgery. The fracture of the coronoid process was fixed in 10 patients (66.7%. The fracture of the radial head was treated by means of internal osteosynthesis in 11 cases (73.3%; in three cases (20%, the radial head was resected; and in one case, only the fragment of the fracture was resected. The collateral ligaments, except for one case, were repaired whenever they were found to be injured; ten cases (66.7% of medial collateral injury and 15 (100% of lateral collateral injury were found. The mean length of the postoperative follow-up was 62 months, with a minimum of 12 months. The postoperative evaluation was done by means of the Bruce score.RESULTS: more than 80% of the patients recovered their functional ranges of motion but, according to the Bruce score, only 26% of the patients achieved results that were considered satisfactory.CONCLUSION: despite the unsatisfactory results, the functional ranges of motion and elbow function could be restored.

  3. LS&T and CMS FY 2004 Feasibility Proposal 04-FS-006 - Ceramic Laser Materials Interim Report - June 8, 2004

    Energy Technology Data Exchange (ETDEWEB)

    Soules, T; Clapsaddle, B; Schaffers, K; Landingham, R

    2005-02-03

    The purpose of this memo is to give an update on our work on ceramic laser materials--feasibility proposal 04-FS-006. Transparent ceramic materials have several major advantages over single crystals in laser applications including, ease and robustness of manufacturing, large apertures, design flexibility, fracture toughness, high activator concentrations, uniformity of composition, no residual stress, and others discussed in the proposal. After a decade of working on making transparent YAG:Nd in 1995 Japanese workers demonstrated samples for the first time that performed as well in lasers as their single crystal counterparts. Since then several laser materials have been made and evaluated. For these reasons, developing ceramic laser materials is the most exciting and futuristic materials topic in today's major solid-state laser conferences. The highlights and executive summary of our work to date are: (1) Ordered a slab of transparent YAG:Nd from Konoshima Chemical Co. for evaluation in the SSHCL. Konoshima is the only company in the world currently making ceramic laser materials for sale. Our slab, the largest one made to date, will arrive within a week and will be evaluated in the SSHCL. (2) Met with the inventor of the Konoshima laser ceramic, Dr. Takagimi Yanagitani, and discussed synthesis and performance of these materials in an all day session at LLNL on May 17. (3) Made our first LLNL in-house nano-sized yttrium aluminum garnet by the CMS sol-gel process. (4) Successfully sintering several samples of nano-particle YAG to near translucency. In this report we will discuss each of the above items and include where relevant pictures or tables or references. In addition to reporting interim results this memo will serve as a reference and a place to put relevant data from subsequent samples throughout the study.

  4. Weighting of items in a tutorial performance evaluation instrument: Statistical analysis and results

    Directory of Open Access Journals (Sweden)

    Piet J. Becker

    2009-04-01

    Full Text Available Weighting of items in an evaluation instrument contributes to more meaningful and valid interpretations of student performance in respect of each learning outcome or item being assessed. It follows that the validity of instruments is important for meaningful inferences about students’ learning performance, including their performance in tutorial groups. The Delphi technique was used to elicit experts’ subjective judgement of the content validity of items in the tutorial performance evaluation instrument in rounds one and two. A sample of eight experts (n = 8 was selected by purposive, maximum variation sampling.

    In round three Delphi a weighted score was determined for each of the instrument items, subitems and Likert scale points through pairwise comparison by the experts. Mathematical modelling of experts’ weighting comparisons, recorded on visual analogue scales, resulted in proportional weights for each item; these weights are expressed as a percentage.

    The final instrument comprised weighted items measured on a rating scale with points that are not equidistant. A computerised tutorial performance evaluator (TPE was developed for accurate, economical and efficient calculation of student scores. The purpose of this article is to report on the statistical analysis and results of the weighting of items in an instrument to assess and evaluate baccalaureate nursing students’ performance in problem-based learning tutorials.

    Opsomming

    Die waardebepaling van items in ‘n evalueringsinstrument dra by tot ‘n meer betekenisvolle en geldige interpretasie van studente se vermoë ten opsigte van elke leeruitkoms of item wat geassesseer word. Hieruit volg dit dat die geldigheid van instrumente belangrik is vir betekenisvolleafleidings betreffende studente se leervermoë, insluitend hulle prestasie in leergroepe. Die Delphi-tegniek is gebruik in rondtes een en twee om kundiges se subjektiewe oordeel oor die

  5. Development of a Probabilistic Safety Assessment Framework for an Interim Dry Storage Facility Subjected to an Aircraft Crash Using Best-Estimate Structural Analysis

    Directory of Open Access Journals (Sweden)

    Belal Almomani

    2017-03-01

    Full Text Available Using a probabilistic safety assessment, a risk evaluation framework for an aircraft crash into an interim spent fuel storage facility is presented. Damage evaluation of a detailed generic cask model in a simplified building structure under an aircraft impact is discussed through a numerical structural analysis and an analytical fragility assessment. Sequences of the impact scenario are shown in a developed event tree, with uncertainties considered in the impact analysis and failure probabilities calculated. To evaluate the influence of parameters relevant to design safety, risks are estimated for three specification levels of cask and storage facility structures. The proposed assessment procedure includes the determination of the loading parameters, reference impact scenario, structural response analyses of facility walls, cask containment, and fuel assemblies, and a radiological consequence analysis with dose–risk estimation. The risk results for the proposed scenario in this study are expected to be small relative to those of design basis accidents for best-estimated conservative values. The importance of this framework is seen in its flexibility to evaluate the capability of the facility to withstand an aircraft impact and in its ability to anticipate potential realistic risks; the framework also provides insight into epistemic uncertainty in the available data and into the sensitivity of the design parameters for future research.

  6. Preoperative evaluation, surgical procedure, follow up and results of 150 cochlear implantations.

    Science.gov (United States)

    Kyriafinis, G; Vital, V; Psifidis, A; Constantinidis, J; Nikolaou, A; Hitoglou-Antoniadou, M; Kouloulas, A

    2007-04-01

    The cochlear implantation is among the most important achievements of medicine and biotechnology in the last 20 years, because it allows individuals who had never heard or had lost their hearing to perceive sound and improve their quality of life. Selection criteria for candidates are strict and are evaluated in each individual by a scientific committee specially trained for implantations which includes Ear Nose and Throat (ENT) surgeon, audiologist, psychiatrist and speech therapist. In our department, the first cochlear implantation was performed in 1995. During the last ten years more than 250 individuals have been evaluated due to profound hearing loss and 170 of them were found to be suitable candidates for cochlear implantation. One hundred and fifty (150) have already been operated and most of them are children with congenital hearing loss. No major or permanent complications were recorded in any of our 150 patients. Activation and fitting/mapping of the cochlear implant is initiated three weeks post-operatively. Regular follow-up and mapping of the implant are held, more frequently in children, along with specialized speech therapy. Each new mapping is evaluated according to the record of the patient with regard to the acoustic perception of sounds and speech and the discrimination of individual elements of phonation based on a protocol that we have created for the needs of Greek language. Speech discrimination (AHEPA Hospital protocol), before the Implantation, at the activation of the cochlear implant and till 4 years of the follow-up showed that in our patients, we obtained better and faster results in post-speech acquisition adults with recent or chronic deafness and in children with congenital deafness operated before the 5th year of age, who underwent special preoperative speech therapy programme, fact which is in agreement with current literature. Patient satisfaction evaluated by "Sanders" psychometrics tests, was achieved in accordance to pre

  7. Results Chains: a Tool for Conservation Action Design, Management, and Evaluation

    Directory of Open Access Journals (Sweden)

    Richard Margoluis

    2013-09-01

    Full Text Available Every day, the challenges to achieving conservation grow. Threats to species, habitats, and ecosystems multiply and intensify. The conservation community has invested decades of resources and hard work to reduce or eliminate these threats. However, it struggles to demonstrate that its efforts are having an impact. In recent years, conservation project managers, teams, and organizations have found themselves under increasing pressure to demonstrate measurable impacts that can be attributed to their actions. To do so, they need to answer three important questions: (1 Are we achieving our desired impact?; (2 Have we selected the best interventions to achieve our desired impact?; and (3 Are we executing our interventions in the best possible manner? We describe results chains, an important tool for helping teams clearly specify their theory of change behind the actions they are implementing. Results chains help teams make their assumptions behind an action explicit and positions the team to develop relevant objectives and indicators to monitor and evaluate whether their actions are having the intended impact. We describe this tool and how it is designed to tackle the three main questions above. We also discuss the purposes for which results chains have been used and the implications of their use. By using results chains, the conservation community can learn, adapt, and improve at a faster pace and, consequently, better address the ongoing threats to species, habitats, and ecosystems.

  8. FY17 Status Report: Research on Stress Corrosion Cracking of SNF Interim Storage Canisters.

    Energy Technology Data Exchange (ETDEWEB)

    Schindelholz, Eric John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bryan, Charles R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Alexander, Christopher L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    This progress report describes work done in FY17 at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of spent nuclear fuel (SNF). Of particular concern is stress corrosion cracking (SCC), by which a through-wall crack could potentially form in a canister outer wall over time intervals that are shorter than possible dry storage times. Work in FY17 refined our understanding of the chemical and physical environment on canister surfaces, and evaluated the relationship between chemical and physical environment and the form and extent of corrosion that occurs. The SNL corrosion work focused predominantly on pitting corrosion, a necessary precursor for SCC, and process of pit-to-crack transition; it has been carried out in collaboration with university partners. SNL is collaborating with several university partners to investigate SCC crack growth experimentally, providing guidance for design and interpretation of experiments.

  9. Augmentation mastopexy after bariatric surgery: evaluation of patient satisfaction and surgical results.

    Science.gov (United States)

    Junior, Wilson Cintra; Modolin, Miguel Luiz Antonio; Rocha, Rodrigo Itocazo; Gemperli, Rolf

    2016-01-01

    to evaluate patient satisfaction and surgical results obtained after mastopexy with breast implant inclusion. we conducted a prospective study of 20 consecutive female patients with a mean age of 39.9 years, submitted to augmentation mastopexy. We applied semi-directed psychological interviews pre and postoperatively. The answers to the evaluations were tabulated, categorized, and allowed patient satisfaction analysis. We evaluated surgical results through photographic analysis of three independent plastic surgeons, in the pre and postoperative periods, when scores were attributed to the following items: breasts shape, breasts volume, breasts symmetry, nipple-areolar complex position, and scar quality and extent. nineteen patients (95%) referred satisfaction with the surgical results attained (pimplantes mamários. estudo prospectivo com 20 pacientes consecutivas do sexo feminino, com média etária de 39,9 anos, que foram submetidas à mastopexia de aumento. Foram aplicadas entrevistas psicológicas semidirigidas nos períodos pré e pós-operatórios e cujas respostas foram tabuladas, divididas em categorias, e possibilitaram a avaliação da satisfação das pacientes. Foi realizada avaliação dos resultados cirúrgicos através da análise fotográfica por três cirurgiões plásticos independentes, nos períodos pré e pós-operatórios, que atribuíram notas aos seguintes itens: forma da mama, volume da mama, simetria entre as mamas, posicionamento do complexo aréolo-papilar e qualidade e extensão das cicatrizes. dezenove pacientes (95%) referiram satisfação com o resultado cirúrgico obtido (p<0,001). A média das somatórias das notas atribuídas pelos três cirurgiões, referentes a cada paciente, variou entre 4,7 e 10, sendo a média geral de 7,28. Os resultados foram considerados bons ou ótimos para 65% da amostra e pobres para 8,4%. houve satisfação de 95% das pacientes com os resultados obtidos pela mastopexia de aumento. A análise fotogr

  10. Results of Formal Evaluation of a Data and Modeling Driven Hydrology Learning Module

    Science.gov (United States)

    Ruddell, B. L.; Sanchez, C. A.; Schiesser, R.; Merwade, V.

    2014-12-01

    New hydrologists should not only develop a well-defined knowledgebase of basic hydrological concepts, but also synthesize this factual learning with more authentic 'real-world' knowledge gained from the interpretation and analysis of data from hydrological models (Merwade and Ruddell, 2012, Wagener et al., 2007). However, hydrological instruction is often implemented using a traditional teacher-centered approach (e.g., lectures) (Wagener, 2007). The emergence of rich and dynamic computer simulation techniques which allow students the opportunity for more authentic application of knowledge (Merwade & Ruddell, 2012). This study evaluates the efficacy of using such data-driven simulations to increase the understanding of the field of hydrology in the lower-division undergraduate geoscience classroom. In this study, 88 students at a local community college who were enrolled in an Introductory Earth Science class were evaluated on their learning performance in a unit on applying the Rational Method to estimate hydrographs and flooding for urban areas. Students were either presented with a data and visualization rich computer module (n=52), or with paper and pencil calculation activities (n=36). All conceptual material presented in lecture was consistent across these two conditions. Students were evaluated for not only changes in their knowledge and application of the concepts within the unit (e.g., effects of urbanization and impervious cover, discharge rates), but also for their broad "T-shaped" profile of professional knowledge and skills. While results showed significant (plearning areas for both groups, there is a significantly larger benefit for the data module group when it came to (1) understanding the effects of urbanization and impervious cover on flooding, (2) applying consistent vocabulary appropriately within context, and (3) explaining the roles and responsibilities of hydrologists and flood managers.

  11. Early Childhood Mental Health Consultation: Results of a Statewide Random-Controlled Evaluation.

    Science.gov (United States)

    Gilliam, Walter S; Maupin, Angela N; Reyes, Chin R

    2016-09-01

    Despite recent federal recommendations calling for increased funding for early childhood mental health consultation (ECMHC) as a means to decrease preschool expulsions, no randomized-controlled evaluations of this form of intervention have been reported in the scientific literature. This study is the first attempt to isolate the effects of ECMHC for enhancing classroom quality, decreasing teacher-rated behavior problems, and decreasing the likelihood of expulsion in targeted children in early childhood classrooms. The sample consisted of 176 target children (3-4 years old) and 88 preschool classrooms and teachers randomly assigned to receive ECMHC through Connecticut's statewide Early Childhood Consultation Partnership (ECCP) or waitlist control treatment. Before randomization, teachers selected 2 target children in each classroom whose behaviors most prompted the request for ECCP. Evaluation measurements were collected before and after treatment, and child behavior and social skills and overall quality of the childcare environment were assessed. Hierarchical linear modeling was used to evaluate the effectiveness of ECCP and to account for the nested structure of the study design. Children who received ECCP had significantly lower ratings of hyperactivity, restlessness, externalizing behaviors, problem behaviors, and total problems compared with children in the control group even after controlling for gender and pretest scores. No effects were found on likelihood of expulsion and quality of childcare environment. ECCP resulted in significant decreases across several domains of teacher-rated externalizing and problem behaviors and is a viable and potentially cost-effective means for infusing mental health services into early childhood settings. Clinical and policy implications for ECMHC are discussed. Copyright © 2016 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  12. Environmental survey of two interim dumpsites, Middle Atlantic Bight from 05 November 1973 to 10 November 1973 (NODC Accession 7501280)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A second oceanographic survey cruise was made to an interim municipal sludge dumpsite and initially to an interim dumpsite for the disposal of industrial acid waste...

  13. Learning the 'SMART' way... results from a pilot study evaluating an interprofessional acute care study day.

    Science.gov (United States)

    Lewis, Robin

    2011-01-01

    A significant number of patients requiring critical care are now being managed outside of critical care facilities. There is evidence that staff looking after these patients lack the necessary knowledge and skills to care for them safely, and that effective pre-registration education can play a significant role in addressing these shortfalls in nurses' knowledge and skills. A team from Sheffield Hallam University, in collaboration with the University of Sheffield, developed a pilot one day interprofessional acute illness programme which was called SMART® (Student Management of Acute illness - Recognition and Treatment). To evaluate the pilot programme, 16 student doctors and 72 student nurses were recruited. A pre- and post-course questionnaire based on the Featherstone et al. (2005) evaluation of ALERT was used to ascertain the students' general level of knowledge of the deteriorating patient, their experiences of and confidence in caring for an acutely unwell patient, and their level of comfort with interprofessional working. The results from the pilot study indicate that the students' levels of knowledge, their levels of confidence and their comfort with interprofessional working all rose after undertaking the programme. The pilot study has a number of implications for the future teaching and learning of acute care clinical skills, within a theoretically based curriculum. 2010 Elsevier Ltd. All rights reserved.

  14. Evaluation of quality of experience in interactive 3D visualization: methodology and results

    Science.gov (United States)

    Tourancheau, Sylvain; Sjöström, Mårten; Olsson, Roger; Persson, Anders; Ericson, Thomas

    2012-03-01

    Human factors are of high importance in 3D visualization, but subjective evaluation of 3D displays is not easy because of a high variability among users. This study aimed to evaluate and compare two different 3D visualization systems (a market stereoscopic display, and a state-of-the-art multi-view display) in terms of user performance and quality of experience (QoE), in the context of interactive visualization. An adapted methodology has been designed in order to focus on 3D differences and to reduce the influence of all other factors. Thirty-six subjects took part in an experiment during which they were asked to judge the quality of their experience, according to specific features. Results showed that a scene understanding and precision was significantly better on the multi-view display. Concerning the quality of experience, visual comfort was judged significantly better on the multi-view display and visual fatigue was reported by 52% of the subjects on the stereoscopic display. This study has permitted to identify some factors influencing QoE such as prior experience and stereopsis threshold.

  15. Summary of results from the National Renewable Energy Laboratory`s vehicle evaluation data collection efforts

    Energy Technology Data Exchange (ETDEWEB)

    Whalen, P.; Kelly, K.; Motta, R.; Broderick, J.

    1996-05-01

    The U.S. DOE National Renewable Energy Laboratory conducted a data collection project for light-duty, alternative fuel vehicles (AFVs) for about 4 years. The project has collected data on 10 vehicle models (from the original equipment manufacturers) spanning model years 1991 through 1995. Emissions data have also been collected from a number of vehicles converted to natural gas (CNG) and liquefied petroleum gas (LPG). Most of the vehicles involved in the data collection and evaluation are part of the General Services Administration`s fleet of AFVs. This evaluation effort addressed the performance and reliability, fuel economy, and emissions of light- duty AFVs, with comparisons to similar gasoline vehicles when possible. Driver-reported complaints and unscheduled vehicle repairs were used to assess the performance and reliability of the AFVs compared to the comparable gasoline vehicles. Two sources of fuel economy were available, one from testing of vehicles on a chassis dynamometer, and the other from records of in-service fuel use. This report includes results from emissions testing completed on 169 AFVs and 161 gasoline control vehicles.

  16. Comparing online and telephone survey results in the context of a skin cancer prevention campaign evaluation.

    Science.gov (United States)

    Hollier, L P; Pettigrew, S; Slevin, T; Strickland, M; Minto, C

    2017-03-01

    A large proportion of health promotion campaign evaluation research has historically been conducted via telephone surveys. However, there are concerns about the continued viability of this form of surveying in providing relevant and representative data. Online surveys are an increasingly popular alternative, and as such there is a need to assess the comparability between data collected using the two different methods to determine the implications for longitudinal comparisons. The present study compared these survey modes in the context of health promotion evaluation research. Data were collected via computer-assisted telephone interviewing and an online panel. In total, 688 and 606 respondents aged between 14 and 45 years completed the online and telephone surveys, respectively. Online respondents demonstrated higher awareness of the advertisement, rated the advertisement as more personally relevant and had better behavioural outcomes compared with the telephone respondents. The results indicate significant differences between the telephone and online surveys on most measures used to assess the effectiveness of a health promotion advertising campaign. Health promotion practitioners could consider the combination of both methods to overcome the deterioration in telephone survey response rates and the likely differences in respondent outcomes.

  17. Evaluation of major polluting accidents in China-Results and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Hou Yu, E-mail: houyu@dufe.edu.cn [Dongbei University of Finance and Economics, 116025 Dalian, Liaoning (China); Department of Environmental Science and Engineering, Tsinghua University, 100084 Beijing (China); Zhang Tianzhu [Dongbei University of Finance and Economics, 116025 Dalian, Liaoning (China); Department of Environmental Science and Engineering, Tsinghua University, 100084 Beijing (China)

    2009-09-15

    Lessons learnt from accidents are essential sources for updating state-of-the-art requirements in pollution accident prevention. To improve this input in the People's Republic of China in a systematic way, a database for collecting and evaluating major pollution accidents is being established. This is being done in co-operation with Chinese Society for Environment Sciences and other national Institutions. At the time of writing over 80 major events from 2002-2006 have been collected. In this paper, a summary evaluation on the major polluting events in China from 2002 to 2006 is presented and some basic lessons drawn shown. There is no a systematic pollution accident notification system currently in China. The results from root cause analysis underline the importance of emergency measures, maintenance, human factor issues and the role of safety organization. Chronic pollution, especially water pollution and air pollution should be paid the same attention as the sudden pollution. It is important to keep in mind that collecting information from major accidents represents a small percentage of the actual number of events taking place.

  18. First results of infrared thermography applied to the evaluation of hydraulic conductivity in rock masses

    Science.gov (United States)

    Pappalardo, Giovanna

    2017-10-01

    An innovative methodological approach using infrared thermography (IRT) provides a potential contribution to the indirect assessment of hydraulic conductivity of jointed rock masses. This technique proved a suitable tool to evaluate the degree of fracturing of rock masses along with their discontinuity systems, which expedite water flow within the rock mass itself. First, based on the latest scientific outcomes on the application of IRT to the geomechanics of rock systems, rock mass surveys were carried out at different outcrops (dolostone, limestone and porphyroid) and hydraulic conductivity was empirically assessed through approaches well known in the international literature. Then, IRT campaigns were performed at each surveyed rock mass, with the purpose of evaluating the corresponding Cooling Rate Index, strictly linked to the cooling attitude of the rock. Such index was correlated with the assessed hydraulic conductivity and satisfactory regression equations were achieved. The interesting results show that hydraulic conductivity values are likely to be linked with the cooling behavior of rock masses, which, in turn, is affected by spacing, aperture and persistence of discontinuities.

  19. Comparative evaluation results of CMS replacement resist for e-beam reticle fabrication

    CERN Document Server

    Kobayashi, H; Asakawa, K; Yokoya, Y; Wada, T

    1999-01-01

    Looking for a CMS replacement resist is an urgent assignment for e- beam reticle fabrication, which enables us to maintain flexibility of reticle fabrications. The CMS-EX series was discontinued in 1995, and its stored resin will be used up completely soon in this year 1999. We then tried to find a replacement resist, and examined commercially available resists SEL-N1000, SEL-N1100 and ZEN4400. We studied their behavior to post-spin baking temperature, in order to bring out their potential, by investigating isolated clear pattern fidelity in details as it was the most tough one to make by a negative-working resist. This paper describes our comparative evaluation results of commercially available negative-working resists to determine a CMS- EX-S replacement for e-beam reticle fabrication. (4 refs).

  20. Evaluation of an additive efficacy in broiler litter microbial level control in field: preliminary results

    Directory of Open Access Journals (Sweden)

    Matteo Pennacchi

    2010-01-01

    Full Text Available The present study was conducted to evaluate in field the efficacy of an additive (SOP® C POULTRY, as an agent for the control of micro-organisms in broiler litter. The Total aerobic Microbial Count (TMC, Staphylococcus species (spp., Coliforms, and Salmonella spp. in broiler litter samples of both the Houses, 2 (H2 and 3 (H3, were determined, and also at the end of each cycle the mortality rate was recorded. The results showed significant reduction of all the microbial counts: P= 0.0078 (CMT, 0,0021 (Staphylococcus spp. and 0.0541 (Coliforms, and mortality (P= 0.00106 in treated litter samples H2 and the control H3.

  1. Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

    Directory of Open Access Journals (Sweden)

    Fábio Pascotto de Oliveira

    2011-06-01

    Full Text Available There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA. OBJECTIVE: Identify by means of diffusion tensor imaging (DTI and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume. METHOD: Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers. RESULTS: There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients. CONCLUSION: Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas.

  2. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: Third Results Reports

    Energy Technology Data Exchange (ETDEWEB)

    Eudy, L.; Chandler, K.

    2012-05-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. NREL has previously published two reports documenting the operation of the fuel cell bus in service. This report provides a summary of the results with a focus on the bus operation from July 2011 through January 2012.

  3. EVALUATION OF FUNCTIONAL RESULTS OF MEDIAL OPENING WEDGE HIGH TIBIAL OSTEOTOMY FOR UNICOMPARTMENTAL OSTEOARTHRITIS VARUS KNEE

    Directory of Open Access Journals (Sweden)

    Shyam Sundar Bakki

    2017-01-01

    Full Text Available BACKGROUND Osteoarthritis commonly affects the medial compartment of knee giving rise to varus deformity in majority of cases. Significant varus deformity further aggravates the pathology due to medialisation of the weight bearing line osteotomy of the proximal tibia realigns this weight bearing axis, thereby relieving pressure on the damaged medial compartment. OWHTO is a promising option in this scenario because it is associated with high accuracy in correcting the deformity and less number of complications when compared to lateral closing wedge HTO or UKA. In this study, we evaluate the functional outcome of HTO in patients with unicompartmental osteoarthritis. MATERIALS AND METHODS This is a prospective study of patients who attended the orthopaedic outpatient clinic in Government Hospital, Kakinada, between August 2013 to August 2015. The patients were evaluated by clinical examination and weight bearing radiographs. The patients who were found to have unicompartmental osteoarthritis with knee pain not relieved by conservative management and who satisfy the inclusion criteria were selected. RESULTS Excellent results can be achieved by appropriate selection criteria and planning with long limb weight bearing radiographs. There is an excellent relief of pain, which can be achieved within first few months postoperatively, which is assessed by VAS score. The KSS- knee score is excellent in 35%, good in 40%, fair in 20% and poor in 5%. The KSS- function score is excellent in 30%, good in 45%, fair in 20% and poor in 5%. There is significant improvement in the range of movement of the knee joint postoperatively. CONCLUSION In this study, we conclude that medial OWHTO is the preferred modality for unicompartmental OA in those aged <60 years and in developing nations like India where squatting is an important function, it has major role as it can restore near normal knee function without disturbing anatomy.

  4. Evaluation of the results of oral food challenges conducted in specialized and general hospitals

    Science.gov (United States)

    Sakai, Kazunori; Sasaki, Kemal; Furuta, Tomoko; Sugiura, Shiro; Watanabe, Yukari; Kobayashi, Takae; Kawabe, Takashi; Morishita, Masashi; Nakanishi, Kumiko

    2017-01-01

    Background Oral food challenge (OFC) tests are conducted in both specialized institutions and general hospitals. We aimed to compare the severity of the conditions of the patients between these 2 types of institutions in order to consider the role of such institutions in society. Objective We evaluated the results of OFC tests for hen's egg, cow's milk, and wheat that were conducted in a specialized institution (Aichi Children's Health and Medical Center [ACHMC], n = 835) and in 4 general hospitals (n = 327) in Aichi prefecture, Japan. Methods The symptoms provoked were scored using the total score (TS) of the Anaphylaxis Scoring Aichi scoring system in combination with the total ingested protein dose (Pro) before the appearance of allergic symptoms. Results The total ingested dose of the challenge-positive patients in ACHMC was significantly less than that in the general hospitals (p < 0.01). The median TS of the provoked symptoms in ACHMC and the general hospitals did not differ to a statistically significant extent in the hen's egg or cow's milk challenges; however, the median TS in ACHMC was significantly lower than that in the general hospitals for the wheat challenge (p = 0.02). The median TS/Pro values in ACHMC were almost identical to the upper 25% of the TS/Pro values in the general hospitals, suggesting that the specialized institution usually managed more severe patients. Conclusion The specialized institution performed OFC tests at a lower threshold dose, but provoked similar TSs to the general hospitals. This evaluation may help in optimizing the distribution of patients to general hospitals and specialized institutions. PMID:29094022

  5. Exploring risk communication - results of a research project focussed on effectiveness evaluation

    Science.gov (United States)

    Charrière, Marie; Bogaard, Thom; Junier, Sandra; Mostert, Erik

    2016-04-01

    The need for effective science communication and outreach efforts is widely acknowledged in the academic community. In the field of Disaster Risk Reduction, the importance of communication is clearly stressed, e.g. in the newly adopted Sendai Framework for Disaster Risk Reduction 2015-2030 (under the 1st priority of action: understanding disaster risk). Consequently, we see increasing risk communication activities. However, the effectiveness of these activities is rarely evaluated. To address this gap, several research activities were conducted in the context of the Marie Curie Initial Training Network "Changes", the results of which we will present and discuss. First, results of a literature review show, among others, that research on effectiveness is mainly focussed on the assessment of users' needs and their ability to understand the content, rather than on the final impact of the risk communication efforts. Moreover, lab-environment research is more often undertaken than assessment of real communication efforts. Second, a comparison between perceptions of risk managers and the general public of risk communication in a French Alps Valley highlighted a gap between the two groups in terms of amount of information needed (who wants more), the important topics to address (what) and the media to use (how). Third, interviews with developers of smartphone applications for disseminating avalanche risk information showed a variety of current practices and the absence of measurements of real their effectiveness. However, our analysis allowed identifying good practices that can be an inspiration for risk communication related to other hazards. Fourth, an exhibition has been set up following a collaborative approached based on stakeholder engagement. Using a pre/post-test design, the immediate impact of the exhibition, which aimed at increasing the risk awareness of the population (Ubaye Valley, France), was measured. The data obtained suggests that visiting the exhibition

  6. SOME STATISTICAL RESULTS REGARDING THE EVALUATION OF THE QUALITY OF THE MASTER EDUCATION

    Directory of Open Access Journals (Sweden)

    POPA IRIMIE

    2011-12-01

    Full Text Available The article emphasizes aspects regarding the evaluation of the higher education's quality. In certain countries, the questionnaires regarding quality of the activity of HEIs (Higher Education Institutions are administrated by specialized institutions led by the Ministry of Education or the university associations. The evaluation principles derive from well-known economic and social theories, evolving even evaluation models (see the SERVQUAL model. As a result of the Bologna Treaty (1999, the European Union has the objective to become an international reference concerning the higher education quality and to be more attractive than in the present for students, professors and researchers from other regions of the world. So as to fulfill these objectives ENQA (European Association for Quality Assurance in Higher Education recommends HEIs to include in their development plans regarding quality aspects five principles described in the article. The practical study refers to the results of a questionnaire applied to the master business students from a Romanian university. In order to assess the level of satisfaction of students in relation to the master programme they are involved in, a questionnaire was applied on a sample of 200 such persons. The responses were then analyzed using multidimensional data analysis methods. Out of these, the present research is based on multiple response analysis. In the questionnaire, students were asked to return their level of satisfaction for different aspects related to the educational process they are involved in. The questions were constructed as five-level Likert items. In this way was insured a connection between answers given at each of the questions assessing the quality of the programme. Only 0.2% of the answers given relate to aspects about which the students were not satisfied at all. These answers represent 3.2% of the number of respondents. 30% of the students were slightly satisfied, returning 57 choices

  7. EVALUATION OF RESULTS IN FRACTURES OF BOTH BONES FOREARM TREATED WITH DYNAMIC COMPRESSION PLATING

    Directory of Open Access Journals (Sweden)

    Sindhuja G

    2017-06-01

    Full Text Available BACKGROUND The anatomical alignment of the bones, the length, the radial bow, and axis should be restored for a good functional outcome. Conservative treatment has resulted in malunion, non-union, synostosis and ultimately poor functional outcome. Internal fixation helps in perfect reduction of fracture fragments in anatomical position by rigid fixation and early mobilisation, the normal functions of the hand can be re-achieved at the earliest. This study has been taken up to evaluate the results of open reduction and internal fixation of the fractures of BBFA with DCP in adults and its advantages and complications. In this study, the rate and time taken for union, the complication, the functional results in terms of forearm rotation and wrist and elbow movements are evaluated. MATERIALS AND METHODS This study includes treatment of 20 cases of fracture of both bones of forearm by open reduction and internal fixation with 3.5 mm DCP from August 2013 to August 2015 at Department of Orthopaedics at Konaseema Institute of Medical Sciences, Amalapuram. Follow-up was done up to September 2015. This is a prospective time bound study. Sample size - 20 patients. Inclusion Criteria- 1. Simple fractures. 2. Open fractures-Gustilo and Anderson type I and type II. 3. Age criteria = 15 to 70 years, both males and females. Exclusion Criteria- 1. Age criteria 0 to 14 years & > 70 years. 2. Radiologically proven segmental fractures and isolated forearm bone fractures. 3. Pathological fracture. 4. Gustilo and Anderson type III. 5. Patient not willing for surgery. 6. Patient unfit for surgery. RESULTS The present study consists of 20 cases of fracture both bones of the forearm. All the cases were openly reduced and internally fixed with 3.5 mm DCP. The study period was from August 2013 to September 2015. The age of these patients ranged from 15-70 years with fracture being most common in 3 rd decade and an average age of 31 years. CONCLUSION Use of separate

  8. Grants for adaptive sports programs for disabled veterans and disabled members of the Armed Forces. Interim final rule.

    Science.gov (United States)

    2014-07-01

    This interim final rule amends Department of Veterans Affairs (VA) regulations to establish a new program to provide grants to eligible entities to provide adaptive sports activities to disabled veterans and disabled members of the Armed Forces. This rulemaking is necessary to implement a change in the law that authorizes VA to make grants to entities other than the United States Olympic Committee for adaptive sports programs. It establishes procedures for evaluating grant applications under this grant program, and otherwise administering the grant program. This rule implements section 5 of the VA Expiring Authorities Extension Act of 2013.

  9. Evaluation of treatment results of patients with Dupuytren's contracture--our clinical experience.

    Science.gov (United States)

    Kobus, Kazimierz; Wójcicki, Piotr; Dydymski, Tomasz; Wegrzyn, Marek; Hamlawi, Fahed

    2007-01-01

    Dupuytren's contracture is a common condition leading to impairment of the function of the hand which affects from 2 to 12 % of the population, mainly males, and presents as progressive contracture of fingers caused by shortening of the palmar aponeurosis. The objective of the work was to present our own approach to managing Dupuytren's disease and evaluate treatment results in patients with hypertrophy of the palmar aponeurosis. Material and method 288 patients with Dupuytren's disease were treated at the Plastic Surgery Hospital in Polanica Zdroj over a period of 25 years (1977-2002). The present paper is a retrospective analysis of treatment results in 253 patients for whom complete medical documentation was available. All patients were operated in local anaesthesia in ischemia. A Bunnell flap skin incision was followed by a fasciectomy of the hypertrophied segment of the palmar aponeurosis. The skin wound was closed using V-Y plasty. Postoperative management involved hand elevation and early rehabilitation. Results Restoration of the full range of motion and total extension in the MP joint and the interphalangeal joints were achieved in 70% and 68% of patients, respectively. Of 145 patients who were professionally active, 132 were able to return to work. Finger amputation was necessary in 2 patients, one patient suffered from arthrodesis and two other developed skin necrosis which was removed with the wound closed by skin grafts. A follow-up examination 6 months after the operation revealed a recurrence in 8 patients and deterioration of hand dexterity with finger stiffness in 4. Conclusions A low complication rate and good treatment results are arguments in favour of the approach adopted at our hospital, i.e. surgery in local anaesthesia in ischemia with compressive bandaging, using a Bunnell flap skin incision followed by radical fasciectomy and V-Y plasty.

  10. 78 FR 41125 - Interim Enforcement Policy for Permanent Implant Brachytherapy Medical Event Reporting

    Science.gov (United States)

    2013-07-09

    ... COMMISSION Interim Enforcement Policy for Permanent Implant Brachytherapy Medical Event Reporting AGENCY...'s permanent implant brachytherapy program. This interim policy affects NRC licensees that are authorized to perform permanent implant brachytherapy. DATES: This policy revision is effective July 9, 2013...

  11. 42 CFR 417.572 - Budget and enrollment forecast and interim reports.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Budget and enrollment forecast and interim reports... forecast and interim reports. (a) Annual submittal. The HMO or CMP must submit an annual operating budget and enrollment forecast, in the form and detail required by CMS, at least 90 days before the beginning...

  12. 78 FR 56752 - Interim Staff Guidance Specific Environmental Guidance for Integral Pressurized Water Reactors...

    Science.gov (United States)

    2013-09-13

    ... activities associated with review of applications for ESPs, design certifications, and COLs by the Office of... comment on, draft Interim Staff Guidance (ISG) ESP/COL-ISG-027, ``Interim Staff Guidance Specific..., early site permits (ESPs), and combined licenses (COLs). DATES: Submit comments by October 15, 2013...

  13. Conceptual design report for immobilized high-level waste interim storage facility (Phase 1)

    Energy Technology Data Exchange (ETDEWEB)

    Burgard, K.C.

    1998-04-09

    The Hanford Site Canister Storage Building (CSB Bldg. 212H) will be utilized to interim store Phase 1 HLW products. Project W-464, Immobilized High-Level Waste Interim Storage, will procure an onsite transportation system and retrofit the CSB to accommodate the Phase 1 HLW products. The Conceptual Design Report establishes the Project W-464 technical and cost basis.

  14. Conceptual design report for immobilized high-level waste interim storage facility (Phase 1)

    Energy Technology Data Exchange (ETDEWEB)

    Burgard, K.C.

    1998-06-02

    The Hanford Site Canister Storage Building (CSB Bldg. 212H) will be utilized to interim store Phase 1 HLW products. Project W-464, Immobilized High-Level Waste Interim Storage, will procure an onsite transportation system and retrofit the CSB to accommodate the Phase 1 HLW products. The Conceptual Design Report establishes the Project W-464 technical and cost basis.

  15. 32 CFR 643.36 - Policy-Interim leasing of excess properties to facilitate economic readjustment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Policy-Interim leasing of excess properties to facilitate economic readjustment. 643.36 Section 643.36 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE Policy § 643.36 Policy—Interim leasing of excess...

  16. 76 FR 15028 - Airport Improvement Program (AIP): Interim Policy Regarding Access to Airports From Residential...

    Science.gov (United States)

    2011-03-18

    ... Federal Aviation Administration Airport Improvement Program (AIP): Interim Policy Regarding Access to Airports From Residential Property AGENCY: Federal Aviation Administration (FAA). ACTION: Interim policy... clarifying FAA policy concerning through-the-fence access to a federally-obligated airport from an adjacent...

  17. 46 CFR 308.202 - Issuance of interim binder; terms and conditions.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Issuance of interim binder; terms and conditions. 308... binder; terms and conditions. Upon acceptance of an application, an interim binder in form as set forth... forth in § 308.207) to the same extent as if such application and policy were made a part of the binder...

  18. 78 FR 72897 - Draft Guidance for Industry on Interim Product Reporting for Human Drug Compounding Outsourcing...

    Science.gov (United States)

    2013-12-04

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Interim Product Reporting for Human Drug Compounding Outsourcing Facilities Under Section 503B of the Federal Food, Drug, and Cosmetic... entitled ``Interim Product Reporting for Human Drug Compounding Outsourcing Facilities Under Section 503B...

  19. [Evaluation of alveolar ridge reconstruction and esthetic result following immediate implant].

    Science.gov (United States)

    Wang, Ying; Lin, Ye; Chen, Bo; Zhang, Yu; Di, Ping

    2016-02-18

    To evaluate the bone alteration subject to remodeling and analyze the esthetic result following immediate implant placement of incisors. In this study, 20 patients (13 women, 7 men) were involved, who needed implants for incisors of maxilla. The patients received 23 immediate implants totally. On the day of surgery and 6 months after the implants were placed, Cone beam CT (CBCT) was taken. The thickness of the alveolar ridge and the vertical change of marginal bone levels onthe mesial and distal aspects of theimplants were measured using the computer software (PlanmecaRomexis Viewer 3.6.0.R). The evaluation of esthetic result by labial convexity score (LCS) and papilla index score (PIS) were analyzed pre-operation and one year after the final crown was delivered. The statistics with paired-t test for the measurement data and Willcoxon test for rating data were done by SPSS 20.0. The survival rate in the two-year follow-up was 100%. The measuring point 1 (MP1), MP2, MP3 and MP4 (0, 2, 4, 6 mm apical to the implant platform, respectively) got significant alterations after 6 months of the follow-up. These differences were statistically significant (PAnkylos System and Replace System, respectively, and the difference was not statistical significant . The esthetic results were quite acceptable. Before treatment, 18 incisors rated 3 for LCS, and 2 incisors rated 4 for LCS;after final restoration, only 5 incisors rated 3 for LCS, and 14 incisors rated 2 for LCS. Before treatment, 15 incisors rated 3 for PIS; after final restoration, 13 incisors rated 3 for PIS. There was no statistically significant difference for the PIS pre-operation and 1 year after final restoration, while there was statistically significant negative change for LCS. Even following the proper surgical technique, the alveolar ridge wall still can't be maintained after immediate implant placed in fresh socket of incisors. The inter-dental papilla could be well maintained, while due to the remodeling of

  20. Evaluation of postoperative results from videoarthroscopic treatment for recurrent shoulder dislocation using metal anchors

    Directory of Open Access Journals (Sweden)

    Éder Menegassi Martel

    2016-02-01

    Full Text Available ABSTRACT OBJECTIVE: To clinically and radiologically evaluate the results from videoarthroscopic treatment using metal anchors in patients with recurrent shoulder dislocation and its complications. METHODS: This was a retrospective study on 47 patients (47 shoulders operated by the shoulder group of the orthopedic hospital between February 2010 and February 2012. A questionnaire, interview and physical and radiographic examinations were used, with the classification of Samilson and Pietro. The mean postoperative follow-up was 33 months (range 12-47 months. The statistical analysis consisted of using Fisher's exact test through the IBM SPSS 22 statistical software. The significance level used was 5%. RESULTS: Recurrence was observed in nine cases. The patients were, on average, 26.5 years old at the first episode, and 19.1% were aged 20 years or under. Among these, 55.6% presented recurrence. In relation to age at the time of the surgical procedure, the average age was 27 years, and 12.8% were aged 20 years or under. Nineteen patients presented prominent anchors and, of these, 21% manifested arthrosis. CONCLUSION: There was a statistically identified correlation between the recurrence rate and age less than or equal to 20 years at the times of first dislocation and the surgical procedure. Further studies should be conducted in order to compare the use of absorbable anchors, which despite higher cost, may provide lower risk of developing glenohumeral arthrosis in some cases.

  1. Evaluation of percutaneous radiologic placement of peritoneal dialysis catheters: technical aspects, results, and complications

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Pyo; Oh, Joo Hyeong; Yoon, Yub; Lee, Tae Won; Ihm, Chun Gyoo [Kyunghee University Hospital, seoul (Korea, Republic of)

    2001-01-01

    To evaluate the technical aspects, results and complications of the percutaneous radiologic placement of peritoneal dialysis catheters. Between December 1999 and April 2001, 26 peritoneal dialysis catheters were placed percutaneously in 26 consecutive patients by interventional radiologists. The patient group consisted of 16 men and ten women with a mean age of 55 (range, 30-77) years. The results and complications arising were reviewed, and the expected patency of the catheters was determined by means of Kaplan-Meier survival analysis. The technical success rate for catheter placement was 100% (26/26 patients). Severe local bleeding occurred in one patient due to by inferior epigastric artery puncture, and was treated by compression and electronic cautery. The duration of catheter implantation ranged from 1 to 510 days and the patency rate was 416{+-}45 days. Catheter malfunction occurred in four patients. In two, this was restored by manipulation in the intervention room, and in one, through the use of urokinase. In three patients, peritonitis occurred. Catheters were removed from four patients due to malfunction (n=2), peritonitis (n=1), and death (n=1). Percutaneous radiologic placement of a peritoneal dialysis catheter is a relatively simple procedure that reduces the complication rate and improves catheter patency.

  2. Reconstruction of the medial patellofemoral ligament: Evaluation of the clinical results of autografts versus allografts.

    Science.gov (United States)

    Calvo Rodríguez, R; Figueroa Poblete, D; Anastasiadis Le Roy, Z; Etchegaray Bascur, F; Vaisman Burucker, A; Calvo Mena, R

    2015-01-01

    The purpose of the study was to evaluate the functional results after medial patellofemoral ligament (MPFL) reconstruction in patients using auto- and allograft. A retrospective study was conducted on 28 patients with recurrent patellar dislocation, with 13 patients (13 knees) undergoing MPFL reconstruction with hamstring autograft, and 15 patients (16 knees) with reconstruction surgery with allograft. The total group included 13 males and 15 females, with an age range of 15 to 38 years. The graft-related morbidity was studied and a clinical assessment was performed using the pre- and postoperative Kujala score. Associated complications were reported for each group. All the patients had more than 12 months of follow up. No recurrent dislocations or graft related complications were reported in either group. The post-operative Kujala subjective knee score was 89.2 in the autograft group, and 92.6 in the allograft group (p >.05). One patient in the allograft group received a revision surgery due to poor positioning of anchors. Another patient in the allograft group had non-displaced patella fracture related to the bone tunnels and another patient had flexion deficit and needed mobilization under anesthesia. There were no significant differences between both groups, and the results were comparable. Copyright © 2014 SECOT. Published by Elsevier Espana. All rights reserved.

  3. Introducing Evidence-Based Principles to Guide Collaborative Approaches to Evaluation: Results of an Empirical Process

    Science.gov (United States)

    Shulha, Lyn M.; Whitmore, Elizabeth; Cousins, J. Bradley; Gilbert, Nathalie; al Hudib, Hind

    2016-01-01

    This article introduces a set of evidence-based principles to guide evaluation practice in contexts where evaluation knowledge is collaboratively produced by evaluators and stakeholders. The data from this study evolved in four phases: two pilot phases exploring the desirability of developing a set of principles; an online questionnaire survey…

  4. Comparison of results from quality control of physical parameters and results from clinical evaluation of mammographic images for the mammography screening facilities in Poland.

    Science.gov (United States)

    Fabiszewska, E; Grabska, I; Jankowska, K; Wesolowska, E; Bulski, W

    2011-09-01

    The material for this study comprised control protocols from 248 mammography screening facilities, prepared by physicists employed at 16 Regional Coordinating Centres and the results from the clinical evaluation of mammographic images in 248 facilities in Poland. All mammograms were evaluated independently by three experts selected from a list approved by the national consultant of radiology and diagnostic imaging. The requirements for proper breast positioning, selection of appropriate parameters for exposure and absence of artefacts were fulfilled only in 38 % of inspected mammography facilities. The requirements of the clinical audit were met only in 15 % of the mammography facilities. The requirements for the physical parameters of mammographic equipment were met only in 28 % of them. The requirements of the quality control (QC) tests and clinical audit were not fulfilled only in 19 % of the mammography facilities. Results from the QC of physical parameters are comparable with results from clinical evaluation of mammographic images in 57 % of the mammography facilities in Poland.

  5. Evaluation of Methacholine Challenge Test Results in Chronic Cough Patients Referring to Clinic of Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    Derakhshan Deilami Gholamreza

    2009-10-01

    Full Text Available Chronic cough is a common problem in patients visiting physicians and its prevalence in different populations range from 3 to 40%. Postnasal drip, asthma and gastroesophageal reflux are the known cause of chronic cough. Although diagnosis of asthma is usually made by clinical signs and spirometeric results, methacholine challenge test is a good diagnostic test in patients who show normal physical examination and spirometeric results. In this study, the results of methacholine challenge test in chronic cough patients are investigated. This is a cross sectional study performed on patients suffering from chronic cough (over 8 weeks, who went to Pulmonary Disease Clinic of Imam Khomeini Hospital in 2006. Postnasal drip, gastroesophageal reflux was evaluated and ruled out in all patients. Then they were tested by methacholine inhalation using low to high doses of methacholine. The results of test was defined as 20% fall in FEV1 and its relationship with age, sex, history of allergic disease, family history of asthma and smoking status was investigated. 81 patients (36 female and 45 male entered this study who had mean age of 32.5 ± 13.06 years. 81.5% of patients had never smoked or closed contact with smokers, 6.2% were passive smokers, 8.6% were smokers and 3.7% had quit smoking. 37% had suffered from chronic cough less than 6 months, 11% for 6-11 months and 52% for more than 12 months. In 26% of patients, family history of asthma was present and 34.5% had a history of one type of allergy. In 29.5% the results of methacholine challenge test was positive, among them 45.8% showed an intense response and 54.2% a moderate response. The test results and its intensity had no statistically significant relationship with age, sex, smoking status, the duration of cough and family history of asthma, but the relationship between methacholine challenge test and the history of allergic disease was significant. Methacholine challenge test can be used as a

  6. [Evaluation of dysphagia. Results after one year of incorporating videofluoroscopy into its study introduction].

    Science.gov (United States)

    García Romero, Ruth; Ros Arnal, Ignacio; Romea Montañés, María José; López Calahorra, José Antonio; Gutiérrez Alonso, Cristina; Izquierdo Hernández, Beatriz; Martín de Vicente, Carlos

    2017-11-09

    Dysphagia is very common in children with neurological disabilities. These patients usually suffer from respiratory and nutritional problems. The videofluoroscopic swallowing study (VFSS) is the most recommended test to evaluate dysphagia, as it shows the real situation during swallowing. To analyse the results obtained in our centre after one year of the implementation of VFSS, the clinical improvement after confirmation, and the prescription of an individualised treatment for the patients affected. VFSS performed in the previous were collected. The following variables were analysed: age, pathology, degree of neurological damage, oral and pharyngeal and/or oesophageal dysphagia and its severity, aspirations, prescribed treatment, and nutritional and respiratory improvement after diagnosis. A statistical analysis was performed using SPSS v21. A total of 61 VFSS were performed. Dysphagia was detected in more than 70%, being moderate-severe in 58%. Aspirations and/or penetrations were recorded in 59%, of which 50% were silent. Adapted diet was prescribed to 56%, and gastrostomy was performed on 13 (21%) patients. A statistical association was found between neurological disease and severity of dysphagia. The degree of motor impairment is related to the presence of aspirations. After VFSS evaluation and treatment adjustment, nutritional improvement was found in Z-score of weight (+0.3SD) and BMI (+0.4SD). There was respiratory improvement in 71% of patients with dysphagia being controlled in the Chest Diseases Department. After implementation of VFSS, a high percentage of patients were diagnosed and benefited from a correct diagnosis and treatment. VFSS is a fundamental diagnostic test that should be included in paediatric centres as a diagnostic method for children with suspected dysphagia. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  7. Community dialogues for child health: results from a qualitative process evaluation in three countries.

    Science.gov (United States)

    Martin, Sandrine; Leitão, Jordana; Muhangi, Denis; Nuwa, Anthony; Magul, Dieterio; Counihan, Helen

    2017-06-05

    Across the developing world, countries are increasingly adopting the integrated community case management of childhood illnesses (iCCM) strategy in efforts to reduce child mortality. This intervention's effectiveness is dependent on community adoption and changes in care-seeking practices. We assessed the implementation process of a theory-driven community dialogue (CD) intervention specifically designed to strengthen the support and uptake of the newly introduced iCCM services and related behaviours in three African countries. A qualitative process evaluation methodology was chosen and used secondary project data and primary data collected in two districts of each of the three countries, in purposefully sampled communities. The final data set included 67 focus group discussions and 57 key informant interviews, totalling 642 respondents, including caregivers, CD facilitators community leaders, and trainers. Thematic analysis of the data followed the 'Framework Approach' utilising both a deduction and induction process. Results show that CDs contribute to triggering community uptake of and support for iCCM services through filling health information gaps and building cooperation within communities. We found it to be an effective approach for addressing social norms around child care practices. This approach was embraced by communities for its flexibility and value in planning individual and collective change. Regular CDs can contribute to the formation of new habits, particularly in relation to seeking timely care in case of child sickness. This study also confirms the value of process evaluation to unwrap the mechanisms of community mobilisation approaches in context and provides key insights for improving the CD approach.

  8. Protecting the confidentiality of interim data: addressing current challenges.

    Science.gov (United States)

    Fleming, Thomas R

    2015-02-01

    There is compelling evidence supporting the importance of maintaining confidentiality of interim data in clinical trials designed to reliably address the benefit-to-risk profile of interventions. While this is widely recognized, creative approaches are needed to achieve this in challenging settings where interim data are released for regulatory review and action, even though the trial would be continued to address its primary hypothesis. An illustration is the recently emerging setting of cardiovascular safety trials in type 2 diabetes mellitus. At the first stage of such trials, if large relative increases in cardiovascular major morbidity/mortality can be ruled out, data can be released solely for the purpose of allowing regulatory decision making about marketing approval. The trial is then continued in the post-marketing setting to address the primary hypothesis regarding whether smaller relative increases can be ruled out. Active rather than passive approaches are needed to protect the integrity of cardiovascular safety trials. Given the importance to trial integrity of maintaining confidentiality of interim data such as the estimated relative effect on cardiovascular risk, a Data Access Plan should be in place in these trials to ensure such data are not revealed to study participants and their caregivers, investigators involved in trial conduct, the sponsor's management team, and the public, until trial completion. A Performance Standards Document also should be developed to pre-specify targeted and minimally acceptable levels for recruitment rate, best real-world achievable adherence, avoidance of cross-ins, and retention rate. This document should specify creative approaches for achieving these targets, oversight procedures during trial conduct to monitor performance levels, and actions to be taken if emerging data indicate minimally acceptable levels are not being reached. In settings where meaningful breaches in confidentiality have occurred, such

  9. The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results

    Directory of Open Access Journals (Sweden)

    F. Trotta

    2011-09-01

    Full Text Available Objective: The aim of this study was to investigate the performance of functional neuro-imaging for describe neurological involvement in Lupus Erithematosus Systemicus. Methods. 20 SLE patients were included into this study (18 females / 2 males. Median age was 40.5 years (range 16 –66 ys, 9 patients with a clear neurological involvement, 7 with aspecific neurological symptoms and 4 were asymptomatics, according to 1999 ACR Classification. All patients were underwent to conventional resonance imaging (RMFLAIR, RM perfusion ( RM-PWI, RM diffusion (RM-DWI and cerebral SPECT. The RM techniques was performed using a 1 Tesla “Signa-Horizon” Tomograph by General Eletric: The data analysis was performed from two indipendent neuroradiologist and than trough coordinated evalutation after coregistration of acquired volumes. Results: In 11/20 patients (55% lesions were demonstrated in RM-FLAIR evaluation, more frequent in cases with focal symptoms than in diffuse. RM-PWI was positive in 50% of cases. SPECT analysis was altered in 85 % of patients. In all patients RM-DWI evaluation was negative. 5 of 29 lesional areas (3 patients showed by SPECT analysis were positive in RM-PWI. None of them was positive in RM-FLAIR study. After coordinated evaluation of RM-FLAIR, SPECT and RM-PWI, 7 findings were considered false positive. 6 Of patients with negative RM-FLAIR were positive in SPECT and 3 in RM-PWI. Only 1 patient was positive in SPECT and RM-PWI. Conclusions: According to the literature, the RM-FLAIR is a very sensitive procedure to describe the lesional charge, especially in patients with focal symptoms. All lesions was considered as stable outcomes due to negativity of RM-DWI analysis. The SPECT is a sensitive technique to individuate cerebral areas of altered perfusion. The coregistration seems to be an helpful method to improve the explanation of uncertain cases. e the sections are prepared for the microscopic analysis of the various

  10. WRF high resolution dynamical downscaling of ERA-Interim for Portugal

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Pedro M.M. [University of Lisbon, Instituto Dom Luiz, Lisbon (Portugal); Faculdade de Ciencias da Universidade de Lisboa, Lisbon (Portugal); Cardoso, Rita M.; Miranda, Pedro M.A.; Medeiros, Joana de [University of Lisbon, Instituto Dom Luiz, Lisbon (Portugal); Belo-Pereira, Margarida; Espirito-Santo, Fatima [Instituto de Meteorologia, Lisbon (Portugal)

    2012-11-15

    This study proposes a dynamically downscaled climatology of Portugal, produced by a high resolution (9 km) WRF simulation, forced by 20 years of ERA-Interim reanalysis (1989-2008), nested in an intermediate domain with 27 km of resolution. The Portuguese mainland is characterized by large precipitation gradients, with observed mean annual precipitation ranging from about 400 to over 2,200 mm, with a very wet northwest and rather dry southeast, largely explained by orographic processes. Model results are compared with all available stations with continuous records, comprising daily information in 32 stations for temperature and 308 for precipitation, through the computation of mean climatologies, standard statistical errors on daily to seasonally timescales, and distributions of extreme events. Results show that WRF at 9 km outperforms ERA-Interim in all analyzed variables, with good results in the representation of the annual cycles in each region. The biases of minimum and maximum temperature are reduced, with improvement of the description of temperature variability at the extreme range of its distribution. The largest gain of the high resolution simulations is visible in the rainiest regions of Portugal, where orographic enhancement is crucial. These improvements are striking in the high ranking percentiles in all seasons, describing extreme precipitation events. WRF results at 9 km compare favorably with published results supporting its use as a high-resolution regional climate model. This higher resolution allows a better representation of extreme events that are of major importance to develop mitigation/adaptation strategies by policy makers and downstream users of regional climate models in applications such as flash floods or heat waves. (orig.)

  11. SOFT TISSUE RECONSTRUCTION OF THE LOWER EXTREMITY: EVALUATION OF SURGICAL RESULTS IN 15 PATIENTS

    Directory of Open Access Journals (Sweden)

    M.J FATEMI

    2003-03-01

    Full Text Available Introduction: There are general guidelines for reconstruction of complex wounds of the Lower extremity. The goal in treatment of these wounds is to preserve a limb that will be more functional than an amputation. Material & Methods: In this study, we evaluate our results in 15 patients with extensive wounds in lower extremities (April - 1998 to march - 2001. Results: The average age of the patients was 31.20 with an age range between 9 to 61 years. Majority of the patients were victims of motor vehicle accident, except two, which developed wounds due to war injury. Distal third of leg was the most common site of trauma and 7 patients had bone fractures, mostly Gustillo III-B. Wound coverage was the most common indication for surgery and free tissue transplantation performed for majority of the patients. Transfer of latissimus dorsi muscle or myocutaneous flap was the most common procedure. One free flap and one fasciocutaneous flap necrosed due to infection and poor technique respectively. Discussion: Our results revealed that the options for reconstruction of significant soft tissue wounds of the upper and lower thigh are included skin graft, local flap and rarely free tissue transfer. The gastrocnemius muscle or myocutaneous flap serve well for supra-patellar, knee and proximal tibial wounds. The soleus muscle flape is probably the most useful flap in middle tibia However, frequently; wounds of this part are best satisfied by micro vascular tissue transplantation. Soft tissue reconstruction in distal tibia and foot is viewed by many as the most challenging of all lower extremity areas. The vast majority of these wounds are best satisfied by micro vascular tissue transfer. Meanwhile, in cases with a modest skin defect, there is the opportunity to utilize either proximally or distally based fasciocutaneous flaps.

  12. Evaluation the Difference between Results of MRI and Electrodiagnostic Methods in Inferior Lumbosacral Discopathies

    Directory of Open Access Journals (Sweden)

    Mohammad Shimia

    2014-01-01

    Full Text Available Introduction: To achieve an appropriate treatment for low back pain we should know the exact reason of the pain. Beside physical examination, imaging modalities like CT scan and MRI are the other diagnostic methods for LBP. Furthermore, electrodiagnostic studies help to diagnose the reason behind radiculopathy. Actually when the reason of radiculopathy is unclear, these methods help to localize the exact nerve root causing the pain and rule out the similar reasons of radiculopathy. The aim of this study was to compare MRI and EMG in diagnosing the reason of lumbosacral radiculopathies. Methods: In this cross sectional descriptive-analytical study, the number of patients who came to neurosurgery clinics with LBP and lumbar discopathy and been evaluated by MRI and EMG were studied. Later, for every patient a questionnaire was completed based on the results achieved from MRI and EMG and the obtained results were compared. Results: 100 patients were participated in this study, 60% female and 40% male. The average age of patients was 39/75 years. The most frequent chief complaint of patients was LBP with a prevalence of 43%. MRI findings showed 64% involvement of L4/L5 level in these patients. On the other hand, EMG findings also showed L4/L5 level involvement in 64% of patients confirming the hypothesis of our study that MRI and EMG findings are compatible with each other in determining the level and intensity of disc involvement. Conclusion: For determining the level of injury in lumbosacral radiculopathies, both MRI and EMG are equally useful. Additionally, in borderline cases we can use EMG to confirm MRI findings to determine the intensity and level of injury. Keywords: Lumbosacral radiculopathy; Magnetic Resonance Imaging; Electromyography

  13. AN INTERIM THERMODYNAMIC PROPERTY FORMULATION FOR SUPERCRITICAL n-HEXANE

    Directory of Open Access Journals (Sweden)

    Azzedine Abbaci

    2010-07-01

    Full Text Available Accurate information on the thermodynamic properties of supercritical fluids is highly sought for the chemical technology, especially, supercritical extraction technology. The thermodynamic properties of fluids near the critical region are strongly affected by the presence of fluctuations and therefore, can not be described by conventional equation. We have investigated an interim formulation for the behavior of the thermodynamic properties of n-hexane in the vicinity of the critical region. For this reason we have used the so-called “crossover model” to describe the thermodynamic properties of n-hexane in a wide range of temperatures and densities around the critical point.

  14. Hospital clinicians' iPad use: an interim report.

    Science.gov (United States)

    Witman, Lydia

    2012-01-01

    An increasing number of hospital libraries are supporting the use of tablet computers such as iPads for access to information resources. To date, this adoption of tablets is not supported by high-quality research evidence. This article provides an interim report on a formal study of clinicians' use of iPads in the hospital setting, currently being conducted at Pennsylvania Hospital in Philadelphia. Other hospital librarians may wish to consider similar factors when beginning to support the use of tablet computers at their own institutions.

  15. Hanford low-level tank waste interim performance assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mann, F.M.

    1996-09-16

    The Hanford Low-Level Tank Waste Interim Performance Assessment examines the long-term environmental and human health effects associated with the disposal of the low-level fraction of the Hanford single- and double-shell tank waste in the Hanford Site 200 East Area. This report was prepared as a good management practice to provide needed information about the relationship between the disposal system design and its performance as early as possible in the project cycle. The calculations in this performance assessment show that the disposal of the low-level fraction can meet environmental and health performance objectives.

  16. The development of an interim generalized gate logic software simulator

    Science.gov (United States)

    Mcgough, J. G.; Nemeroff, S.

    1985-01-01

    A proof-of-concept computer program called IGGLOSS (Interim Generalized Gate Logic Software Simulator) was developed and is discussed. The simulator engine was designed to perform stochastic estimation of self test coverage (fault-detection latency times) of digital computers or systems. A major attribute of the IGGLOSS is its high-speed simulation: 9.5 x 1,000,000 gates/cpu sec for nonfaulted circuits and 4.4 x 1,000,000 gates/cpu sec for faulted circuits on a VAX 11/780 host computer.

  17. Hanford low-level tank waste interim performance assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mann, F.M.

    1997-09-12

    The Hanford Low-Level Tank Waste Interim Performance Assessment examines the long-term environmental and human health effects associated with the disposal of the low-level fraction of the Hanford single and double-shell tank waste in the Hanford Site 200 East Area. This report was prepared as a good management practice to provide needed information about the relationship between the disposal system design and performance early in the disposal system project cycle. The calculations in this performance assessment show that the disposal of the low-level fraction can meet environmental and health performance objectives.

  18. The PDF4LHC Working Group Interim Report

    CERN Document Server

    Alekhin, Sergey; Ball, Richard D.; Bertone, Valerio; Blumlein, Johannes; Botje, Michiel; Butterworth, Jon; Cerutti, Francesco; Cooper-Sarkar, Amanda; de Roeck, Albert; Del Debbio, Luigi; Feltesse, Joel; Forte, Stefano; Glazov, Alexander; Guffanti, Alberto; Gwenlan, Claire; Huston, Joey; Jimenez-Delgado, Pedro; Lai, Hung-Liang; Latorre, Jose I.; McNulty, Ronan; Nadolsky, Pavel; Olaf Moch, Sven; Pumplin, Jon; Radescu, Voica; Rojo, Juan; Sjostrand, Torbjorn; Stirling, W.J.; Stump, Daniel; Thorne, Robert S.; Ubiali, Maria; Vicini, Alessandro; Watt, Graeme; Yuan, C.-P.

    2011-01-01

    This document is intended as a study of benchmark cross sections at the LHC (at 7 TeV) at NLO using modern parton distribution functions currently available from the 6 PDF fitting groups that have participated in this exercise. It also contains a succinct user guide to the computation of PDFs, uncertainties and correlations using available PDF sets. A companion note, also submitted to the archive, provides an interim summary of the current recommendations of the PDF4LHC working group for the use of parton distribution functions and of PDF uncertainties at the LHC, for cross section and cross section uncertainty calculations.

  19. ANALYSIS OF PROFESSORS’ EVALUATION AT LA SALLE UNIVERSITY MÉXICO FROM 2010 TO 2016: WHAT THE RESULTS INDICATE?

    Directory of Open Access Journals (Sweden)

    Flegl, Martin

    2017-09-01

    Full Text Available La Salle University México (La Salle uses an internal system of professors’ evaluation, which main purpose is to evaluate professors’ performance and secure high quality of teaching at all of its faculties. Since its inception in 2010, La Salle has obtained 517,635 individual evaluations of 45,346 courses. However, no additional analysis of the obtained results has ever been done. This article provides introductory analysis of the accumulated results at faculty level. The main objective is to analyze whether there are differences between faculties regarding the evaluation. Although the results are highly skewed towards the maximal evaluation at all faculties, there are statistically significant differences. The next important task is to investigate what factors influence the evaluation. Moreover, as this is the introductory analysis, the article concludes with possible future steps that should be consider regarding eventual structural changes in the evaluation system.

  20. Initial results of fully coupled water cycle EURO-CORDEX evaluation simulations with TerrSysMP from 1989-2008

    Science.gov (United States)

    Kulkarni, Ketan; Keune, Jessica; Gasper, Fabian; Sharples, Wendy; Naz, Bibi; Goergen, Klaus; Kollet, Stefan

    2017-04-01

    Interactions and feedbacks between the sub-surface including groundwater, the land surface and the atmosphere are highly relevant for weather and the climate system. However, many state of the art global and regional earth system models do not consider the impacts of groundwater dynamics, which are critical for the closure of the hydrological cycle on different spatial and temporal scales. In this study we implement the coupled Terrestrial Systems Modelling Platform over the EURO-CORDEX domain for evaluation experiments in line with the CORDEX experiment design in order to study how the explicit treatment of groundwater affects states and fluxes of the terrestrial water and energy cycle over a continental domain on longer simulation time spans and in relation to existing uncoupled EURO-CORDEX RCM simulations. The Terrestrial Systems Modelling Platform (TerrSysMP) is a fully coupled scale-consistent numerical modelling system, currently consisting of the COSMO NWP model, the Community Land Model (CLM) and the ParFlow variably saturated surface and subsurface hydrological model, coupled with the external coupler OASIS3(-MCT). TerrSysMP allows for a physically-based representation of transport processes across scales down to sub-km resolution with explicit feedbacks between the individual compartments, including 3D groundwater dynamics and a full representation of the terrestrial hydrological cycle. The land surface-groundwater subsystem is spun up with a 1979-1989 cyclic climatological forcing derived from ERA-Interim reanalysis until an equilibrated groundwater state is achieved. Using this as the initial conditions, the fully coupled simulation for the period from 1989 to 2008 are carried out over the EURO-CORDEX domain at 12 km resolution using ERA-Interim as lateral boundary forcing. COSMO physics settings are in line with the CCLM consortium runs done for EURO-CORDEX to allow for a better comparison. The JUBE2 (Juelich Benchmarking Environment) workflow engine

  1. 29 CFR 1614.505 - Interim relief.

    Science.gov (United States)

    2010-07-01

    ... provide notification will result in the dismissal of the agency's appeal. (5) The agency may, by notice to... extent of the temporary or conditional restoration of the employee to duty status in the position specified in the decision, pending the outcome of the agency appeal. The employee may decline the offer of...

  2. 12 CFR 268.505 - Interim relief.

    Science.gov (United States)

    2010-01-01

    ... provide notification will result in the dismissal of the Board's appeal. (5) The Board may, by notice to... to the extent of the temporary or conditional restoration of the employee to duty status in the position specified in the decision, pending the outcome of the Board appeal. The employee may decline the...

  3. Evaluation of photopatch test allergens for Indian patients of photodermatitis: Preliminary results

    Directory of Open Access Journals (Sweden)

    Nidhi Jindal

    2011-01-01

    Full Text Available Background: There is a strong need to develop a photopatch test tray suitable for Indian patients of photodermatitis as European/Scandinavian photopatch test trays may not be wholly relevant for them. Aim: We carried out this study using photoallergens relevant in the Indian context to determine their relevance in patients of photodermatitis. Methods: Thirty patients (M:F, 23:7 between 19 and 76 years of age of photodermatitis and 10 controls were patch- and photopatch tested with 20 common photoallergens. In addition, the patients were also (photo patch tested with articles of daily use as and when these were suspected to be the cause. Results: Forty-three positive reactions to one or more antigens were seen in 22 (74% patients. Fourteen positive photopatch tests to seven allergens were observed in 10 (33% patients, and nine (30% of them had a definite relevance. The most common contact allergen was fragrance mix (FM (30%, followed by p-phenylenediamine (20% and Parthenium hysterophorous (17%. The definite relevance of the patch- and photopatch tests could be correlated in 47% of these patients. Conclusions: FM is the most common contact and photocontact allergen among the various photopatch test antigens. Although differences in technique and evaluation make direct comparison between different centers difficult, still photopatch testing remains an integral part and gold standard for the work-up of the photosensitive patients.

  4. Developing Teenage Youth's Science Identity Through an Astronomy Apprenticeship: Summative Evaluation Results

    Science.gov (United States)

    Barros-Smith, R.; Porro, I.; Norland, E.

    2012-08-01

    We report on the results from the summative evaluation of the Youth Astronomy Apprenticeship (YAA) covering three years of implementation of the program. YAA is a year-long, out-of-school time initiative that connects urban teenage youth with astronomy as an effective way to promote scientific literacy and overall positive youth development. The program employs the strategies of a traditional apprenticeship model, common in crafts and trade guilds as well as in higher education. During the apprenticeship, youth develop knowledge and skills to create informal science education projects; through these projects they demonstrate their understanding of astronomy and use their communication skills to connect to general audiences. For some youth, participation extends across multiple years and their responsibilities for program implementation become multifaceted. Through exposing youth to astronomy investigations and providing opportunities to connect with audiences outside their program and communities, YAA expands scientific literacy to include assuming a science identity. We subscribe to the concept of science identity that describes personal ownership and integration of science into an individual's sense of self through processes of comprehension and personal meaning making. In the YAA context, science identity extends to and includes assuming an actual science advocacy role. Our methods for measuring the development of a science identity included assessments of a youth's perceived and actual understanding of science (cognitive construct), leadership in science (behavior construct), and commitment to science (affective construct).

  5. The safety of UK video telemetry units: results of a national service evaluation.

    Science.gov (United States)

    Kandler, Rosalind; Lai, Ming; Ponnusamy, Athi; Bland, Jeremy; Pang, Catherine

    2013-12-01

    To assess patient safety during seizures occurring on UK video telemetry units and identify factors in unit infrastructure which may improve safety with the intention of producing national guidelines. A prospective multicentre national service evaluation of the occurrence of adverse events and level of nurse attendance during seizures occurring on video telemetry units was performed. Data from 272 seizures from 27 video telemetry units across the UK were analysed. Adverse events occurred in 12% of seizures: 7% were physical events such as falls or respiratory compromise and 5% were unnoticed seizures. Nursing staff did not attend the patients in 44% of seizures and attendance was delayed beyond 30s in a further 29%. Only 27% of seizures were attended by a Healthcare Professional within half a minute. The most important factor shown to improve timely attendance of patients during seizures was the presence of a nurse dedicated to the telemetry bed(s). The site of the telemetry bed (bay or cubicle) and method of observation (direct or indirect) was less important. An optimal nurse-to-patient ratio was difficult to identify but the study suggests that a ratio of at least 1 nurse to 4 patients is appropriate. The results provide an evidence base for the production of national standards and guidelines for surveillance of patients during video telemetry to improve patient safety. Copyright © 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  6. "5 A Day" achievement badge for urban boy scouts: formative evaluation results.

    Science.gov (United States)

    Cullen, K W; Baranowski, T; Baranowski, J; Warnecke, C; de Moor, C; Nwachokor, A; Hajek, R A; Jones, L A

    1998-01-01

    Certain cancers are more common among African Americans (AA). Fruit and vegetables (F&V) reduce cancer risk, but Americans, and African Americans in particular, do not meet the "5 A Day" goal. Scouting organizations, particularly urban Boy Scout groups that target inner-city youth, provide promising channels for nutritional behavioral change programs. Focus groups were conducted with urban Boy Scouts and their parents to identify factors influencing F&V consumption and evaluate potential intervention activities. Twenty-four-hour dietary recalls were collected from 85 area Boy Scouts. A national data set was used to obtain values for F&V consumption by African American and European American (boys age 0-16). Vegetable preferences were low and a negative peer influence for vegetables was reported. The group has limited food-preparation skills, but both parents and scouts reported that F&V were available in their homes. Use of goal setting and use of problem-solving techniques were limited. The local scouts' mean F&V intake was 3.2 servings per day. Ethnic differences in F&V consumption were identified in the national data. Based on these results and previous interventions in schools, an overall structure for the intervention was developed to include eight weekly troop sessions and two camping sessions, parent newsletters, seven weekly home badge assignments, and ten comic books.

  7. A multi-site evaluation of innovative approaches to increase tuberculosis case notification: summary results.

    Directory of Open Access Journals (Sweden)

    Jacob Creswell

    Full Text Available BACKGROUND: Globally, TB notifications have stagnated since 2007, and sputum smear positive notifications have been declining despite policies to improve case detection. We evaluate results of 28 interventions focused on improving TB case detection. METHODS: We measured additional sputum smear positive cases treated, defined as the intervention area's increase in case notification during the project compared to the previous year. Projects were encouraged to select control areas and collect historical notification data. We used time series negative binomial regression for over-dispersed cross-sectional data accounting for fixed and random effects to test the individual projects' effects on TB notification while controlling for trend and control populations. RESULTS: Twenty-eight projects, 19 with control populations, completed at least four quarters of case finding activities, covering a population of 89.2 million. Among all projects sputum smear positive (SS+ TB notifications increased 24.9% and annualized notification rates increased from 69.1 to 86.2/100,000 (p = 0.0209 during interventions. Among the 19 projects with control populations, SS+TB case notifications increased 36.9% increase while in the control populations a 3.6% decrease was observed. Fourteen (74% of the 19 projects' SS+TB notification rates in intervention areas increased from the baseline to intervention period when controlling for historical trends and notifications in control areas. CONCLUSIONS: Interventions were associated with large increases in TB notifications across many settings, using an array of interventions. Many people with TB are not reached using current approaches. Different methods and interventions tailored to local realities are urgently needed.

  8. Results of a prospective evaluation of three methods of management of pediatric cataracts.

    Science.gov (United States)

    Basti, S; Ravishankar, U; Gupta, S

    1996-05-01

    Although a variety of approaches to manage cataracts in children have been studied, no consensus exists on the optimum approach. The authors, therefore, conducted a prospective, nonrandomized, consecutive study to evaluate three most commonly adopted methods of management of pediatric cataracts. Lensectomy anterior vitrectomy (LAV), extracapsular cataract extraction with intraocular lens implantation (ECCE + IOL) and ECCE, primary posterior capsulotomy, anterior vitrectomy with IOL (ECCE + PPC + AV + IOL) were the surgical procedures performed. Aphakia in the LAV group was corrected with spectacles or contact lenses. Intraoperative and postoperative results were analyzed. Discrete variables among the three groups were compared using chi square test. One hundred ninety-two eyes were included in the study. There was no statistically significant difference in the intraoperative complications in the three groups. During a mean follow-up period of 11.3 months, postoperative obscuration of the visual axis was seen in 43.7% of eyes in the ECCE + IOL group and in 3.65% of eyes in the ECCE + PC + AV + IOL (p contact lenses were prescribed developed corneal infiltrates. Severe postoperative anterior uveitis occurred in 15.9% and 13.8% of eyes in the ECCE + PPC + AV + IOL and ECCE + IOL groups, respectively. None of the eyes that underwent LAV developed this complication (P maintenance of a clear visual axis, provided optimum refractive correction, and was not associated with increased risk of short-term complications. Continued follow-up of these eyes is necessary to conclude on the long term results of this technique.

  9. Evaluation of anterior chest wall implanted port: technical aspects, results, and complications

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Young Hwan; Oh, Joo Hyeong; Yoon, Yup; Kim, Si Young [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    2000-07-01

    To evaluate the technical aspects, results and complications of patients with implanted anterior chest wall port. Between April 1997 and June 1999, a total of 63 implanted ports were placed at the anterior chest wall of 63 consecutive patients by interventional radiologists. The indications were chemotherapy in 61 patients and total parenteral nutrition in two. The peripheral portion of the subclavian vein was punctured under fluoroscopic guidance via ipsilateral peripheral vein during venography. A central venous catheter was placed in the superior vena cava, and using the subcutaneous tunneling method, a connected infusion port was implanted at the anterior chest wall. Results and complications were reviewed, and by means of Kaplan-Meier survival analysis, the expected patency of the port was determined. The technical success rate for implanted port at the anterior chest wall was 100% (63/63 patients). In two patients, hematoma and oozing were treated by compression. The duration of port implantation ranged from 12 to 855 (mean, 187) days, and the port patency rate was 305.7{+-}47.6 days. In seven patients (completed chemotherapy (n=3D3), central venous thrombosis (n=3D3) catheter-related infection (n=3D1)), the port was removed. Catheter obstruction occurred in two patients, and in one, the use of urokinase led to successful recanalization. Sixteen patients died of an underlying malignancy, but no catheter-related death was noted. Implantation of an anterior chest wall port is a safe and useful procedure, with long patency, for patients requiring chemotherapy and long-term venous access. (author)

  10. EVALUATION OF THE RESULTS OF THE USE OF VEPTR IN PATIENTS WITH SCOLIOSIS

    Directory of Open Access Journals (Sweden)

    JOÃO PAULO SILVA ARAÚJO

    Full Text Available ABSTRACT Objective: Evaluation of the results of the use of VEPTR (Vertical Expandable Prosthetic Titanium Rib - Synthes Spine Co.(r, West Chester, Pennsylvania, USA as an option in spinal instrumentation without fusion in younger children with scoliosis, considering the complications inherent to spinal fusion in this age group. Methods: Sixteen (16 patients with scoliosis, regardless of etiology, with a mean age of 5.2 (3-8 years, were followed up by Spine Surgery Group at Hospital Getúlio Vargas, Recite-PE, and were submitted to surgical correction of the deformity using VEPTR, from April/2009 to July/2014. The survey was conducted through medical register review, and photographic and radiographic records, with the measurement of pre- and postoperative curves by the Cobb method. Results: The mean values of Cobb angle in the preoperative period, in the immediate postoperative period and after the last distraction were, respectively, 84.1° (112°-60°, 55.4° (92°-16° and 64.4° (100°-16°, with an average initial correction of 28.7° (34.1% and final correction of 19.7° (23.4%. The mean follow-up was 23.1 (0-61 months with an average distraction of 3.1 (0-8. The complication rate in this study was 62.5%. Conclusion: The VEPTR presented considerable correction rates of scoliosis curves in patients whose age contraindicate the spinal fusion methods. It is necessary to improve the technique and the implant itself in order to reduce complication rates, which can be considered relatively high, in addition to the conduction of more studies with longer follow-up to determine the actual efficacy of the implant and the maintenance of long-term correction.

  11. Short-term results of a prospective randomized evaluator blinded multicenter study comparing TVT and TVT-Secur.

    Science.gov (United States)

    Andrada Hamer, Maria; Larsson, Per-Göran; Teleman, Pia; Etén-Bergqvist, Christina; Persson, Jan

    2011-07-01

    The aim of this prospective randomized multicenter study was to compare TVT (tension-free vaginal tape) with TVT-Secur in terms of efficacy and safety. We set out to enrol 280 stress incontinent women with a half time interim analysis of short-term cure and a continuous registration of adverse events. Of 133 randomized women, 126 were operated and 123 (TVT n = 62, TVT-Secur n = 61) available for 2 months follow-up. No significant differences were found between groups regarding demographics or grade of incontinence. At 2 months follow-up, subjective cure rate following TVT-Secur was significantly lower than for TVT (72% and 92%, respectively, p = 0.01). Three major complications occurred in the TVT-Secur group: tape erosion into the urethra, a tape inadvertently placed inside the bladder, and an immediate postoperative bleeding from the corona mortis. No major complications occurred in the TVT group. No significant differences were found between groups regarding perioperative bleeding, hospital stay, urge symptoms, or postoperative urinary tract infections. Median time for surgery was 13 and 22 min for TVT-Secur and TVT, respectively (p TVT-Secur procedure had a significantly lower subjective cure rate than the retropubic TVT procedure. Due to this, in addition to three serious complications in the TVT-Secur group, we decided to stop further enrolment after the interim analysis. We discourage from further use of the TVT-Secur.

  12. [Reliability for detection of developmental problems using the semaphore from the Child Development Evaluation test: Is a yellow result different from a red result?

    Science.gov (United States)

    Rizzoli-Córdoba, Antonio; Ortega-Ríosvelasco, Fernando; Villasís-Keever, Miguel Ángel; Pizarro-Castellanos, Mariel; Buenrostro-Márquez, Guillermo; Aceves-Villagrán, Daniel; O'Shea-Cuevas, Gabriel; Muñoz-Hernández, Onofre

    The Child Development Evaluation (CDE) is a screening tool designed and validated in Mexico for detecting developmental problems. The result is expressed through a semaphore. In the CDE test, both yellow and red results are considered positive, although a different intervention is proposed for each. The aim of this work was to evaluate the reliability of the CDE test to discriminate between children with yellow/red result based on the developmental domain quotient (DDQ) obtained through the Battelle Development Inventory, 2nd edition (in Spanish) (BDI-2). The information was obtained for the study from the validation. Children with a normal (green) result in the CDE were excluded. Two different cut-off points of the DDQ were used (BDI-2): Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  13. Outcomes of antiretroviral therapy in Vietnam: results from a national evaluation.

    Directory of Open Access Journals (Sweden)

    Duc Bui Nguyen

    Full Text Available Vietnam has significantly scaled up its national antiretroviral therapy (ART program since 2005. With the aim of improving Vietnam's national ART program, we conducted an outcome evaluation of the first five years of the program in this concentrated HIV epidemic where the majority of persons enrolled in HIV care and treatment services are people who inject drugs (PWID. The results of this evaluation may have relevance for other national ART programs with significant PWID populations.Retrospective cohort analysis of patients at 30 clinics randomly selected with probability proportional to size among 120 clinics with at least 50 patients on ART.Charts of patients whose ART initiation was at least 6 months prior to the study date were abstracted. Depending on clinic size, either all charts or a random sample of 300 charts were selected. Analyses were limited to treatment-naïve patients. Multiple imputations were used for missing data.Of 7,587 patient charts sampled, 6,875 were those of treatment-naïve patients (74.4% male, 95% confidence interval [CI]: 72.4-76.5, median age 30, interquartile range [IQR]: 26-34, 62.0% reported a history of intravenous drug use, CI: 58.6-65.3. Median baseline CD4 cell count was 78 cells/mm(3 (IQR: 30-162 and 30.4% (CI: 25.8-35.1 of patients were at WHO stage IV. The majority of patients started d4T/3TC/NVP (74.3% or d4T/3TC/EFV (18.6%. Retention rates after 6, 12, 24, and 36 months were 88.4% (CI: 86.8-89.9, 84.0% (CI: 81.8-86.0, 78.8% (CI: 75.7-81.6, and 74.6% (CI: 69.6-79.0. Median CD4 cell count gains after 6, 12, 24, and 36 months were 94 (IQR: 45-153, 142 (IQR: 78-217, 213 (IQR: 120-329, and 254 (IQR: 135-391 cells/mm(3. Patients who were PWID showed significantly poorer retention.The study showed good retention and immunological response to ART among a predominantly PWID group of patients despite advanced HIV infections at baseline.

  14. Preparation for tritiated waste management of fusion facilities: Interim storage WAC

    Energy Technology Data Exchange (ETDEWEB)

    Decanis, C., E-mail: christelle.decanis@cea.fr [CEA, DEN, Centre de Cadarache, F-13108 Saint-Paul-lez-Durance (France); Canas, D. [CEA, DEN/DADN, Centre de Saclay, F-91191 Gif-sur-Yvette cedex (France); Derasse, F. [CEA, DEN, Centre de Cadarache, F-13108 Saint-Paul-lez-Durance (France); Pamela, J. [CEA, Agence ITER-France, F-13108 Saint-Paul-lez-Durance (France)

    2016-11-01

    Highlights: • Fusion devices including ITER will generate tritiated waste. • Interim storage is the reference solution offering an answer for all types of tritiated radwaste. • Interim storage is a buffer function in the process management and definition of the waste acceptance criteria (WAC) is a key milestone in the facility development cycle. • Defining WAC is a relevant way to identify ahead of time the studies to be launched and the required actions to converge on a detailed design for example material specific studies, required treatment, interfaces management, modelling and monitoring studies. - Abstract: Considering the high mobility of tritium through the package in which it is contained, the new 50-year storage concepts proposed by the French Alternative Energies and Atomic Energy Commission (CEA) currently provide a solution adapted to the management of waste with tritium concentrations higher than the accepted limits in the disposals. The 50-year intermediate storage corresponds to 4 tritium radioactive periods i.e., a tritium reduction by a factor 16. This paper details the approach implemented to define the waste acceptance criteria (WAC) for an interim storage facility that not only takes into account the specificity of tritium provided by the reference scheme for the management of tritiated waste in France, but also the producers’ needs, the safety analysis of the facility and Andra’s disposal requirements. This will lead to define a set of waste specifications that describe the generic criteria such as acceptable waste forms, general principles and specific issues, e.g. conditioning, radioactive content, tritium content, waste tracking system, and quality control. This approach is also a way to check in advance, during the design phase of the waste treatment chain, how the future waste could be integrated into the overall waste management routes and identify possible key points that need further investigations (design changes, selection

  15. Piloted Simulator Evaluation Results of New Fault-Tolerant Flight Control Algorithm

    NARCIS (Netherlands)

    Lombaerts, T.J.J.; Smaili, M.H.; Stroosma, O.; Chu, Q.P.; Mulder, J.A.; Joosten, D.A.

    2010-01-01

    A high fidelity aircraft simulation model, reconstructed using the Digital Flight Data Recorder (DFDR) of the 1992 Amsterdam Bijlmermeer aircraft accident (Flight 1862), has been used to evaluate a new Fault-Tolerant Flight Control Algorithm in an online piloted evaluation. This paper focuses on the

  16. D2.3.3 Evaluation results of the LinkedUp VICI competition

    NARCIS (Netherlands)

    Drachsler, Hendrik

    2014-01-01

    This document D2.3.3 is the final report of Task 2.4 – Evaluation of challenge submissions. Task 2.4 is about the actual assessment of the participating projects within the LinkedUp Veni, Vidi and Vici competition on the basis of the LinkedUp Evaluation Framework (D2.2.1). The main objective of

  17. D2.3.2 Evaluation results of the LinkedUp VIDI competition

    NARCIS (Netherlands)

    Drachsler, Hendrik; Stoyanov, Slavi; Herder, Eelco; Marieke, Guy; Maren, Scheffel

    2014-01-01

    This document D2.3.2 is the second report of Task 2.4 - Evaluation of challenge submissions. Task 2.4 is about the actual assessment of the participating projects within the LinkedUp Veni, Vidi and Vici competition on the basis of the LinkedUp Evaluation Framework (D2.2.1). The main objective of

  18. Aligning Evaluation Results and Professional Development: Driving Systemic Human Capital Management Reform

    Science.gov (United States)

    Behrstock-Sherratt, Ellen; Jacques, Catherine

    2012-01-01

    This brief provides district and other educational leaders with research-based information on aligning professional development policies with teacher evaluations to drive more comprehensive human capital management. First, this brief describes an aligned evaluation and professional development system. Next, it discusses existing models and…

  19. Learning Demonstration Interim Progress Report -- July 2010

    Energy Technology Data Exchange (ETDEWEB)

    Wipke, K.; Spirk, S.; Kurtz, J.; Ramsden, T.

    2010-09-01

    This report discusses key results based on data through December 2009 from the U.S. Department of Energy's (DOE) Controlled Hydrogen Fleet and Infrastructure Validation and Demonstration Project, also referred to as the National Fuel Cell Electric Vehicle (FCEV) Learning Demonstration. The report serves to help transfer knowledge and lessons learned within various parts of DOE's hydrogen program, as well as externally to other stakeholders. It is the fourth such report in a series, with previous reports being published in July 2007, November 2007, and April 2008.

  20. Second Interim Report NASA - easyJet Collaboration on the Human Factors Monitoring Program (HFMP) Study

    Science.gov (United States)

    Srivistava, Ashok N.; Barton, Phil

    2012-01-01

    This is the second interim report jointly prepared by NASA and easyJet on the work performed under the agreement to collaborate on a study of the factors entailed in flight and cabin-crew fatigue, and decreases in performance associated with fatigue. The objective of this Agreement is to generate reliable procedures that aid in understanding the levels and characteristics of flight and cabin-crew fatigue factors, both latent and proximate, whose confluence will likely result in unacceptable crew performance. This study entails the analyses of numerical and textual data collected during operational flights. NASA and easyJet are both interested in assessing and testing NASA s automated capabilities for extracting operationally significant information from very large, diverse (textual and numerical) databases; much larger than can be handled practically by human experts.

  1. Quarrels on the meaning of youth: what the interim measure ends

    Directory of Open Access Journals (Sweden)

    Raquel Alvarenga Sena Venera

    2016-10-01

    Full Text Available http://dx.doi.org/10.5007/1984-8420.2016v17n2p120 This article is a reflection from the context of the publication of the Measure no. 746, from 2016, that became Bill no. 13,415, in 2017, but also, and mainly, based on the group of former analyses about youth meanings in disputes in the language game on the curriculum policies regarding high school. These analyses were made in a net of investigations, with different epistemological paths, with very close intentions and results. The present reflection highlights one of these analyses, which, through discourse analysis together with Orlandi (2011, analyzed  the Programa Ensino Médio Inovador (ProEMI; Innovative High School Program. These analyses provide visibility to the youth meanings in disputes, and the present reflection understands the interim measure as an attempt to end the dispute.

  2. Interim report on updated microarray probes for the LLNL Burkholderia pseudomallei SNP array

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, S; Jaing, C

    2012-03-27

    The overall goal of this project is to forensically characterize 100 unknown Burkholderia isolates in the US-Australia collaboration. We will identify genome-wide single nucleotide polymorphisms (SNPs) from B. pseudomallei and near neighbor species including B. mallei, B. thailandensis and B. oklahomensis. We will design microarray probes to detect these SNP markers and analyze 100 Burkholderia genomic DNAs extracted from environmental, clinical and near neighbor isolates from Australian collaborators on the Burkholderia SNP microarray. We will analyze the microarray genotyping results to characterize the genetic diversity of these new isolates and triage the samples for whole genome sequencing. In this interim report, we described the SNP analysis and the microarray probe design for the Burkholderia SNP microarray.

  3. Variability of Iberian upwelling implied by ERA-40 and ERA-Interim reanalyses

    Directory of Open Access Journals (Sweden)

    José M. R. Alves

    2013-05-01

    Full Text Available The Regional Ocean Modeling System ocean model is used to simulate the decadal evolution of the regional waters in offshore Iberia in response to atmospheric fields given by ECMWF ERA-40 (1961–2001 and ERA-Interim (1989–2008 reanalyses. The simulated sea surface temperature (SST fields are verified against satellite AVHRR SST, and they are analysed to characterise the variability and trends of coastal upwelling in the region. Opposing trends in upwelling frequency are found at the northern limit, where upwelling has been decreasing in recent decades, and at its southern edge, where there is some evidence of increased upwelling. These results confirm previous observational studies and, more importantly, indicate that observed SST trends are not only due to changes in radiative or atmospheric heat fluxes alone but also due to changes in upwelling dynamics, suggesting that such a process may be relevant in climate change scenarios.

  4. Electric car design. Interim summary report, Phase I: deliverable item 9

    Energy Technology Data Exchange (ETDEWEB)

    1977-05-09

    The work included in this Interim Summary Report is part of the Electric Car Program, the goal of which is to develop by 1979 a totally new electric car with substantially improved performance over those electric cars available in 1976. The rationale used in designing a four-passenger electric car for use in an urban environment is presented. The approach taken was to design an electric car utilizing current technology. On the basis of tradeoff analyses, upgrading improvements were identified which would permit the electric car to more nearly meet all of the ERDA near-term goals. The electric car design, including the chassis, drive train, major components, and the control are summarized. The Phase I electric car design will meet many of the ERDA near-term goals. Upgrading development programs are identified which, when incorporated in Phase II vehicle development, will result in upgraded performance, which essentially meets ERDA's near-term goals.

  5. Glass packages in interim storage; Les verres dans les stockages

    Energy Technology Data Exchange (ETDEWEB)

    Jacquet-Francillon, N.

    1994-10-01

    This report summarize the current state of knowledge concerning the behavior of type C waste packages consisting of vitrified high-level solutions produced by reprocessing spent fuel. The composition and the physical and chemical properties of the feed solutions are reviewed, and the vitrification process is described. Sodium alumino-borosilicate glass compositions are generally employed - the glass used at la Hague for LWR fuel solutions, for example, contains 45 % SiO{sub 2}. The major physical, chemical, mechanical and thermal properties of the glass are reviewed. In order to allow their thermal power to diminish, the 3630 glass packages produced (as of January 1993) in the vitrification facilities at Marcoule and La Hague are placed in interim storage for several decades. The actual interim storage period has not been defined, as it is closely related to the concept and organization selected for the final destination of the packages: a geological repository. The glass behavior under irradiation is described. Considerable basic and applied research has been conducted to assess the aqueous leaching behavior of nuclear containment glass. The effects of various repository parameters (temperature, flow rate, nature of the environmental materials) have been investigated. The experimental findings have been used to specify a model describing the kinetics of aqueous corrosion of the glass. More generally all the ``source term`` models developed in France by the CEA or by ANDRA are summarized. (author). 152 refs., 33 figs.

  6. Advantages on dry interim storage for spent nuclear fuel

    Energy Technology Data Exchange (ETDEWEB)

    Romanato, L.S. [Centro Tecnologico da Marinha em Sao Paulo, Av. Professor Lineu Prestes 2468, 05508-900 Sao Paulo (Brazil); Rzyski, B.M. [IPEN/ CNEN-SP, 05508-000 Sao Paulo (Brazil)]. e-mail: romanato@ctmsp.mar.mil.br

    2006-07-01

    When the nuclear fuel lose its ability to efficiently create energy it is removed from the core reactor and moved to a storage unit waiting for a final destination. Generally, the spent nuclear fuel (SNF) remains inside concrete basins with water within the reactors facility for the radioactive activity decay. Water cools the generated heat and shields radioactivity emissions. After some period of time in water basins the SNF can be sent to a definitive deposition in a geological repository and handled as radioactive waste or to reprocessing installations, or still wait for a future solution. Meanwhile, SNF remains stored for a period of time in dry or wet installations, depending on the method adopted by the nuclear power plant or other plans of the country. In many SNF wet storage sites the capacity can be fulfilled very quickly. If so, additional area or other alternative storage system should be given. There are many options to provide capacity increase in the wet storage area, but dry storages are worldwide preferred since it reduces corrosion concerns. In the wet storage the temperature and water purity should be constantly controlled whereas in the dry storage the SNF stands protected in specially designed canisters. Dry interim storages are practical and approved in many countries especially that have the 'wait and see' philosophy (wait to see new technologies development). This paper shows the advantages of dry interim storages sites in comparison with the wet ones and the nowadays problems as terrorism. (Author)

  7. Climate change : we are at risk : interim report

    Energy Technology Data Exchange (ETDEWEB)

    Oliver, D.; Wiebe, J.

    2003-06-01

    Between November 2002 and May 2003 the Standing Senate Committee on Agriculture and Forestry travelled across Canada to hear the views of farmer organizations, rural associations, ecotourism groups and environmental organizations regarding concerns about climate change and the impact it may have on the agriculture and forestry sectors and rural communities. The Committee also examined potential adaptation strategies focusing on primary production, practices, technologies, ecosystems and other related areas. Farmers and forest operators are already facing changes in market conditions, domestic regulations, trade policies and technology. This interim report expressed the concerns of farmers and forest operators. It includes a review of the Saguenay flood of 1996, the Red River flood of 1997, the ice storm of 1998, and droughts since 1999. It also includes a discussion on climate change and its biophysical and economic effects on agriculture, forestry, water resources, rural communities, and Aboriginal communities. This interim report also briefly outlines the Kyoto Protocol, the emissions trading system, and the decarbonization of global energy systems. It emphasized the need for integrated research and government policies and programs that encourage adaptation to climate change. The final report will be released in October 2003 and will provide specific recommendations to ensure that Canada responds to the concerns of farmers and forest operators and to ensure continued prosperity in these sectors. refs., figs.

  8. Interim sanitary landfill groundwater monitoring report. 1996 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Bagwell, L.A.

    1997-01-01

    Eight wells of the LFW series monitor groundwater quality in the Steed Pond Aquifer (Water Table) beneath the Interim Sanitary Landfill at the Savannah River Site. These wells are sampled semiannually to comply with the South Carolina Department of Health and Environmental Control Modified Municipal Solid Waste Permit 025500-1120 and as part of the SRS Groundwater Monitoring Program. Trichlorofluoromethane and 1,1,1-trichloroethane were elevated in one sidegradient well and one downgradient well during 1996. Zinc was elevated in three downgradient wells and also was detected in the associated laboratory blanks for two of those wells. Specific conductance was elevated in one background well and one sidegradient well. Barium and copper exceeded standards in one sidegradient well, and dichloromethane (a common laboratory contaminant) was elevated in another sidegradient well. Barium, copper, and dichloromethane were detected in the associated blanks for these wells, also. The groundwater flow direction in the Steed Pond Acquifer (Water Table) beneath the Interim Sanitary Landfill was to the southeast (universal transverse Mercator coordinates). The flow rate in this unit was approximately 210 ft/year during first quarter 1996 and 180 ft/yr during third quarter 1996.

  9. Interim storage of power reactor spent nuclear fuel (SNF) and its potential application to SNF separations and closed fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    Levy, Salomon, E-mail: slevy112@aol.com

    2009-10-15

    Interim, centralized, engineered (dry cask) storage facilities for USA light water power reactor spent nuclear fuel (SNF) should be implemented to complement and to offer much needed flexibility while the Nuclear Regulatory Commission is funded to complete its evaluation of the Yucca Mountain License and to subject it to public hearings. The interim sites should use the credo reproduced in Table 1 [Bunn, M., 2001. Interim Storage of Spent Nuclear Fuel. Harvard University and University of Tokyo] and involve both the industry and government. The sites will help settle the 50 pending lawsuits against the government and the $11 billion of potential additional liabilities for SNF delay damages if Yucca Mountain does not being operation in 2020 [DOE, 2008a. Report to Congress on the Demonstration of the Interim Storage of Spent Nuclear Fuel from Decommissioned Nuclear Power Stations (December)]. Under the developing consensus to proceed with closed fuel cycles, it will be necessary to develop SNF separation facilities with stringent requirements upon separation processes and upon generation of only highly resistant waste forms. The location of such facilities at the interim storage sites would offer great benefits to those sites and assure their long term viability by returning them to their original status. The switch from once-through to closed fuel cycle will require extensive time and development work as illustrated in 'The Path to Sustainable Nuclear Energy' [DOE, 2005. The Path to Sustainable Nuclear Energy. Basic and Applied Research Opportunities for Advanced Fuel Cycles. DOE (September)]. A carefully crafted long term program, funded for at least 5 years, managed by a strong joint government-industry team, and subjected to regular independent reviews should be considered to assure the program stability and success. The new uncertainty about Yucca Mountain role raises two key issues: (a) what to do with the weapons and other high level government

  10. [The use of LapSim virtual reality simulator in the evaluation of laparoscopic surgery skill. Preliminary results].

    Science.gov (United States)

    Tomulescu, V; Popescu, I

    2004-01-01

    The aim of this study is to establish if the results obtained in the evaluation of the candidates for the laparoscopic surgery competence using the LapSim virtual reality simulator are comparable with intraoperative evaluation. For this study has been evaluated in front of the LapSim and in the operating room a number of 12 surgeons who have achieved the criteria for laparoscopic surgery competence evaluation. The results of any one of the candidates have been evaluated, on Lapsim and by the exam committee in the operation room relating to four criteria: (1) utilization of 300 camera; (2) manipulation and coordination of laparoscopic instruments, suturing; (3) grasping and cutting; (4) clip applying. The evaluation has been made relating to the time need for every candidate to perform the asked task, and the subjective evaluation of the examining committee with marks from 1 to 10. The LapSim evaluation, in concordance with intraoperative evaluation managed to establish 2 candidates with deficiency in manipulation and coordination of laparoscopic instruments, and difficulty in the laparoscopic bidimensional field orientation. We consider this experiment only the beginning in the evaluation of the utility of virtual reality simulator in the training and examination of the results in laparoscopic surgery. We consider that large series of subjects with different levels of knowledge in laparoscopic surgery have to be evaluated to conclude if the benefit of laparoscopic surgery virtual reality simulator is the same as in airplane pilots.

  11. [Prospective Evaluation of the Quality of the Results of Thyroid Surgery in an ENT-Department].

    Science.gov (United States)

    Issing, Peter Rolf; Tebben, Hendrik; Wenger, Martin; Köhler, Torsten

    2017-04-01

    Although the thyroid gland is located in the neck it is not a matter of fact that it is a clinical issue for the otorhinolaryngologist in Germany. Probably due to historic reasons general surgeons usually perform operations on the thyroid. As at our department this kind of treatment is an established procedure we prospectively evaluated our thyroid cases in order to present our results.The prospective study started in the year of 2014. So far 231 patients were enrolled with an average age of 53,5 years (16-89). The sex ratio showed a preponderance of the female patients with 187 and 64 males. In 155 cases we didn't insert a Redon-drainage. The mean operation time was 133 min. The preoperative concentration of calcium was 2.44 mg/ml with a postoperative decrease to 2.21 mg/ml. In cases of malignancies revealed in histology a second procedure with complete thyroidectomy and neck dissection took place immediately afterwards.Many symptoms of disorders of the thyroid become manifest in a genuine region of our speciality. Therefore we cannot detect any convincing reason why head and neck surgeons should not perform thyroidectomies. Skills like the specific clinical examination, the preoperative diagnostic work flow including sonography, the precise surgical management of soft tissue and neural structures and the postoperative care are typical features of our discipline. However, besides the surgeon's expertise a close collaboration with the colleagues of nuclear medicine and the general practitioner respectively the endocrinologist is mandatory in order to achieve a high quality of treatment. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Radiation Hardening by Software Techniques on FPGAs: Flight Experiment Evaluation and Results

    Science.gov (United States)

    Schmidt, Andrew G.; Flatley, Thomas

    2017-01-01

    We present our work on implementing Radiation Hardening by Software (RHBSW) techniques on the Xilinx Virtex5 FPGAs PowerPC 440 processors on the SpaceCube 2.0 platform. The techniques have been matured and tested through simulation modeling, fault emulation, laser fault injection and now in a flight experiment, as part of the Space Test Program- Houston 4-ISS SpaceCube Experiment 2.0 (STP-H4-ISE 2.0). This work leverages concepts such as heartbeat monitoring, control flow assertions, and checkpointing, commonly used in the High Performance Computing industry, and adapts them for use in remote sensing embedded systems. These techniques are extremely low overhead (typically radiation hardened processor. The recently concluded STP-H4 flight experiment was an opportunity to upgrade the RHBSW techniques for the Virtex5 FPGA and demonstrate them on-board the ISS to achieve TRL 7. This work details the implementation of the RHBSW techniques, that were previously developed for the Virtex4-based SpaceCube 1.0 platform, on the Virtex5-based SpaceCube 2.0 flight platform. The evaluation spans the development and integration with flight software, remotely uploading the new experiment to the ISS SpaceCube 2.0 platform, and conducting the experiment continuously for 16 days before the platform was decommissioned. The experiment was conducted on two PowerPCs embedded within the Virtex5 FPGA devices and the experiment collected 19,400 checkpoints, processed 253,482 status messages, and incurred 0 faults. These results are highly encouraging and future work is looking into longer duration testing as part of the STP-H5 flight experiment.

  13. A multi-site evaluation of innovative approaches to increase tuberculosis case notification: summary results.

    Science.gov (United States)

    Creswell, Jacob; Sahu, Suvanand; Blok, Lucie; Bakker, Mirjam I; Stevens, Robert; Ditiu, Lucica

    2014-01-01

    Globally, TB notifications have stagnated since 2007, and sputum smear positive notifications have been declining despite policies to improve case detection. We evaluate results of 28 interventions focused on improving TB case detection. We measured additional sputum smear positive cases treated, defined as the intervention area's increase in case notification during the project compared to the previous year. Projects were encouraged to select control areas and collect historical notification data. We used time series negative binomial regression for over-dispersed cross-sectional data accounting for fixed and random effects to test the individual projects' effects on TB notification while controlling for trend and control populations. Twenty-eight projects, 19 with control populations, completed at least four quarters of case finding activities, covering a population of 89.2 million. Among all projects sputum smear positive (SS+) TB notifications increased 24.9% and annualized notification rates increased from 69.1 to 86.2/100,000 (p = 0.0209) during interventions. Among the 19 projects with control populations, SS+TB case notifications increased 36.9% increase while in the control populations a 3.6% decrease was observed. Fourteen (74%) of the 19 projects' SS+TB notification rates in intervention areas increased from the baseline to intervention period when controlling for historical trends and notifications in control areas. Interventions were associated with large increases in TB notifications across many settings, using an array of interventions. Many people with TB are not reached using current approaches. Different methods and interventions tailored to local realities are urgently needed.

  14. Evaluation of Results in Patients with Acute Upper Gis Bleeding: A Goverment Hospital Experience

    Directory of Open Access Journals (Sweden)

    Bilge Bas

    2016-01-01

    Full Text Available Aim: The aim was to assess the characteristics of patients with upper gastrointestinal system (GIS bleeding in our clinic. Material and Method: The patients who admitted to Usak State Hospital Gastroenterology Department with upper gastrointestinal system bleeding were retrospectively evaluated between May 2009 and March 2012. The patients were assessed for age, sex, complaints, history of medication, management, history of bleeding, laboratory findings, endoscopic findings, need for transfusion, hospitalization duration and mortality. Results: 392 patients admitted to our department with upper gastrointestinal system bleeding. 263 (67.1% of the patient were male and 129 (32.9% were female. It was presented only melena in 120 (%30.6 patients, hematemesis in 140 (%35.7 patients and both hematemesis and melena in 132 (%33.7 patients at admission. The mean hemoglobin level was 7.8±1.5 g/dl, and the mean hematocrit level was 27.4±4%. It was established coronary artery disease in 50 (12.8% patients, diabetes mellitus in 20 (5.1% patients, cerebrovascular disease in 8 (2% patients and peripheral arterial disease in 4 (1% patients. We presented 194 (49.5% bulbus ulcer, 117 (29.8% erosive gastritis, 35 (8.9% gastric ulcer in patients at upper gastrointestinal system endoscopy. We established Helicobacter pylori infection in 264 (67.3 % patients. Discussion: Duodenal ulcer and eritematous gastritis are the most common causes of upper GIS bleedings. In addition, Helicobacter pylori infection is keep in mind as a important bleeding cause in that patients. It is useful to give stomach acid suppressor therapy to the patients who have coronary heart disease, cerebrovascular disease and diabetes mellitus, especially if they have gastric complaints.

  15. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey

    Directory of Open Access Journals (Sweden)

    Sivanandy P

    2016-07-01

    Full Text Available Palanisamy Sivanandy,1 Mari Kannan Maharajan,1 Kingston Rajiah,1 Tan Tyng Wei,2 Tan Wee Loon,2 Lim Chong Yee2 1Department of Pharmacy Practice, School of Pharmacy, 2School of Pharmacy, International Medical University, Wilayah Persekutuan Kuala Lumpur, Malaysia Background: Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use.Objective: To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia.Methods: A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted.Results: The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of “staff training and skills” were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup.Conclusion: The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety. Keywords

  16. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey

    Science.gov (United States)

    Sivanandy, Palanisamy; Maharajan, Mari Kannan; Rajiah, Kingston; Wei, Tan Tyng; Loon, Tan Wee; Yee, Lim Chong

    2016-01-01

    Background Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use. Objective To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia. Methods A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted. Results The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of “staff training and skills” were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup. Conclusion The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety. PMID:27524887

  17. Evaluation of bronchoscopic lung volume reduction coil treatment results in patients with severe emphysema.

    Science.gov (United States)

    Gulsen, Askin; Sever, Fidan; Girgin, Pelin; Tamci, Necdet Batuhan; Yilmaz, Hatice

    2017-09-01

    Bronchoscopic lung volume reduction coil (BLVR-C) implantation is an alternative therapeutic approach that can be applied together with medical treatment for patients with severe emphysema. BLVR-C is both easier and safer in terms of complications than volume reduction surgery. This study aimed to evaluate medium-term outcomes following BLVR-C treatment. Forty patients who underwent BLVR-C between September 2013 and March 2014 were reviewed retrospectively. We compared changes between the baseline and 6-month post-procedural results with respect to pulmonary function tests, a 6-min walk test (6MWT), chronic obstructive pulmonary disease (COPD) assessment test (CAT), St. George's Respiratory Questionnaire (SGRQ), and pulmonary artery pressure (PAP) and arterial blood gas analyses. Secondary outcomes included procedure-related and follow-up complications. An average of 9.5 (range: 5-11) coils were placed per lung in an average procedural duration of 20.8 ± 7.0 min (range: 9-45) min. Six months after BLVR-C treatment, significant improvements were observed in patients' pulmonary function tests and quality of life. Changes were observed in the forced exhalation volume in 1 s (+150 mL), residual volume (-14.5%), 6MWT (+48 m), SGRQ (-10.5) and CAT Score (-7.5). Changes in the PAP and partial pressure of carbon dioxide values were not significant, and pneumothorax did not occur. In a 6-month follow-up, 11 cases of COPD exacerbation (41.4%), 7 cases of pneumonia (16.9%) and 1 death (2%) occurred. Treatment in 1 case was postponed because of hypotension and bradycardia during the process. BLVR-C treatment appears to be effective over the medium-term and safe for patients with severe emphysema. © 2015 John Wiley & Sons Ltd.

  18. PROJECT INTERIM ACTIVITY REPORT FOR SEMESTER 4

    CERN Document Server

    Koutchouk, J P

    2011-01-01

    The EuCARD project gathers 37 European partners engaged in state-of the-art technologies to upgrade major research accelerators. The main components and objectives of the project are: • Networks, focused on communication and dissemination, neutrino physics facilities, performance of hadron colliders and accelerators, and RF technologies, resulting in 40 leading laboratories worldwide being associated with EuCARD. • Transnational access facilities, offering precision beams and muon cooling setup, and pulsed irradiation for material testing. • Joint research: 21 R&D tasks grouped under the following themes: o Investigating the feasibility of new superconducting magnets and electrical links using Nb3Sn and/or High Temperature Superconductors. o Investigating the gradient limits for radiofrequency (RF) accelerating structures, whether normal or superconducting, together with specific issues of linear colliders such as extreme geometrical stabilization. o Developing more robust collimators for the protec...

  19. TropFlux: air-sea fluxes for the global tropical oceans-description and evaluation

    Digital Repository Service at National Institute of Oceanography (India)

    PraveenKumar, B.; Vialard, J.; Lengaigne, M.; Murty, V.S.N.; McPhaden, M.J.

    This paper evaluates several timely, daily air-sea heat flux products (NCEP, NCEP2, ERA-Interim and OAFlux/ISCCP) against observations and present the newly developed TropFlux product. This new product uses bias-corrected ERA-interim and ISCCP data...

  20. How healthcare systems evaluate their advance care planning initiatives: Results from a systematic review.

    Science.gov (United States)

    Biondo, Patricia D; Lee, Lydia D; Davison, Sara N; Simon, Jessica E

    2016-09-01

    Advance care planning initiatives are being implemented across healthcare systems around the world, but how best to evaluate their implementation is unknown. To identify gaps and/or redundancies in current evaluative strategies to help healthcare systems develop future evaluative frameworks for ACP. Systematic review. Peer-reviewed and gray literature searches were conducted till February 2015 to answer: "What methods have healthcare systems used to evaluate implementation of advance care planning initiatives?" A PICOS framework was developed to identify articles describing the implementation and evaluation of a health system-level advance care planning initiative. Outcome measures were mapped onto a conceptual quality indicator framework based on the Institute of Medicine and Donabedian models of healthcare quality. A total of 46 studies met inclusion criteria for analysis. Most articles reported on single parts of a healthcare system (e.g. continuing care). The most common outcome measures pertained to document completion, followed by healthcare resource use. Patient-, family-, or healthcare provider-reported outcomes were less commonly measured. Concordance measures (e.g. dying in place of choice) were reported by only 26% of studies. The conceptual quality indicator framework identified gaps and redundancies in measurement and is presented as a potential foundation from which to develop a comprehensive advance care planning evaluation framework. Document completion is frequently used to evaluate advance care planning program implementation; capturing the quality of care appears to be more difficult. This systematic review provides health system administrators with a comprehensive summary of measures used to evaluate advance care planning and may identify gaps in evaluation within their local context. © The Author(s) 2016.